Ytterbium(III) triflate catalyzed tandem Friedel-Crafts alkylation/hydroarylation of propargylic alcohols with phenols as an expedient route to indenols.
A method to prepare indenols efficiently by ytterbium(III) triflate catalyzed tandem Friedel-Crafts alkylation/hydroarylation of propargylic alcohols with phenols is described. The reaction was accomplished in moderate to excellent yields and regioselectivity under mild conditions and offers a straightforward and convenient one step synthetic route to bioactive indenols and its derivatives.
Zhang
Xiaoxiang
X
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637616, Singapore.
Teo
Wan Teng
WT
Chan
Philip Wai Hong
PW
D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry; D011412:Propanolamines / Q000138:chemical synthesis* / Q000737:chemistry; D020005:Propanols / Q000737:chemistry*; D015018:Ytterbium / Q000737:chemistry*
D000438:Alcohols; D000480:Alkynes; D007192:Indenes; D008698:Mesylates; D010636:Phenols; D011412:Propanolamines; D020005:Propanols; C002989:indenolol; C028255:propargyl alcohol; D015018:Ytterbium