Value of nasal mucosa congestion index in choosing treatment strategies for chronic rhinosinusitis.
CONCLUSIONS
The mucosa compliance in lesions is determined by the congestion index, enabling us to determine whether the patient is sensitive to pharmacotherapy and to choose surgical management rationally.


OBJECTIVE
To explore the correlation between the nasal mucosa congestion index and tissue remodeling in chronic rhinosinusitis (CRS) and to provide objective evidence for clinical choice of therapeutic methods.


METHODS
Forty-four patients with CRS who underwent nasal endoscopic surgery were enrolled in the study. The congestion indexes of the nasal mucosa were measured using an acoustic rhinometer and specimens were taken from the uncinate process mucosa to evaluate vascular density and degree of fibrosis. The correlations were statistically analyzed.


RESULTS
There was an inverse correlation between the congestion index and degree of fibrosis (r=- 0.522, p=0.00) and a direct correlation between the congestion index and vascular density (r=0.838, p=0.00) in nasal mucosa. There was a significant correlation between the congestion index and the combination of degree of fibrosis and vascular density with a determination coefficient (R(2)) of 0.778.
Department of Otorhinolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing, China.
Hong-Rui
HR
Zang
Tong
T
Wang
Yun-Chuan
YC
Li
Sheng-Zhong
SZ
Zhang
Er-Zhong
EZ
Fan
De-Min
DM
Han
D000293:Adolescent; D000328:Adult; D000368:Aged; D002196:Capillaries / Q000473:pathology; D003187:Compliance; D003661:Decision Support Techniques; D004724:Endoscopy; D005260:Female; D005355:Fibrosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D012220:Rhinitis / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery*; D023842:Rhinometry, Acoustic; D012852:Sinusitis / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery*; D013223:Statistics as Topic; D016896:Treatment Outcome; D055815:Young Adult