Use of sodium thiosulfate in the treatment of calciphylaxis.
Calciphylaxis is an infrequent but severe entity found in chronic dialysis patients. Its clinical pattern consists of tissue ischemia with itchy and painful subcutaneous nodules and plaques, most often located on the abdomen, buttocks, thighs and/or legs. These injuries evolve to extensive superficial necrosis of the skin overlying the panniculitis, with ulceration, overinfection and consequent sepsis. Current treatment modalities used to counteract this pathology are not entirely effective. A new treatment reported for calciphylaxis, is the use of intravenous sodium thiosulfate. This inorganic salt is already used in the treatment of intoxication caused by cyanide, in patients with calcific nephrolithiasis and tumoral calcinosis, with very good and safe results. We herewith report a case of calciphylaxis that was cured using intravenous sodium thiosulphate treatment.
Musso
Carlos G
CG
Department of Nephrology, Hospital Italiano de Buenos Aires, Argentina. carlosmusso@gmail.com
Enz
Paula
P
Vidal
Flavia
F
Gelman
Rodolfo
R
Lizarraga
Aldana
A
Giuseppe
Luis Di
LD
Kowalczuk
Alicia
A
Garfi
Leonardo
L
Galimberti
Ricardo
R
Algranati
Luis
L
D002115:Calciphylaxis / Q000188:drug therapy* / Q000473:pathology; D002614:Chelating Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008875:Middle Aged; D006435:Renal Dialysis; D012867:Skin / Q000473:pathology; D013885:Thiosulfates / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D002614:Chelating Agents; D013885:Thiosulfates; C017717:sodium thiosulfate