3D versus 2D dynamic 82Rb myocardial blood flow imaging in a canine model of stunned and infarcted myocardium.
OBJECTIVE
Previous studies have shown the ability of rubidium-82 ((82)Rb) positron emission tomography (PET) imaging to quantitatively measure myocardial blood flow (MBF), many of which are performed using two-dimensional (2D) imaging. Three-dimensional (3D) imaging provides increased sensitivity and may result in decreased costs owing to a reduction in the required injected activity of radiotracer. This study compares 2D and 3D (82)Rb PET MBF results obtained in the same imaging session.


METHODS
Three-dimensional and 2D (82)Rb perfusion imaging was performed in canines on a GE Discovery LS PET/CT scanner at rest and during hyperemia in stunned and infarcted tissue. MBF (ml/min/g) was determined using a 1-compartment model and an extraction correction of the uptake rate and analyzed using a standard 17-segment model.


RESULTS
A strong, significant correlation was present (rho = 0.95, P<0.0001). Average 3D MBF values were slightly lower at rest and higher during stress versus 2D. MBF results in normal, stunned, and infarcted tissue differed by 7% on average and significant increases in MBF from rest to hyperemia were noted with both the techniques.


CONCLUSIONS
These results imply that MBF results obtained in 3D are comparable with traditional 2D imaging. Therefore, it may be possible to use 3D imaging with lower administered activity, helping to reduce costs and patient dose without compromising quantitative information.
Lekx
Katie S
KS
Lawson Health Research Institute and Nuclear Medicine Department, St. Joseph's Health Care, London, Canada.
deKemp
Robert A
RA
Beanlands
Rob S B
RS
Wisenberg
Gerald
G
Wells
Glenn
G
Stodilka
Robert Z
RZ
Lortie
Mireille
M
Klein
Ran
R
Zabel
Pamela
P
Kovacs
Michael S
MS
Sykes
Jane
J
Prato
Frank S
FS
D000818:Animals; D003326:Coronary Circulation; D004195:Disease Models, Animal; D004285:Dogs; D021621:Imaging, Three-Dimensional; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D017682:Myocardial Stunning / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012146:Rest; D012414:Rubidium Radioisotopes; D013312:Stress, Physiological; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
D012414:Rubidium Radioisotopes