STUDIES ON HAEMOPHILUS INFLUENZAE : I. INFECTION OF MICE WITH MUCIN SUSPENSIONS OF THE ORGANISM.
1. It has been shown that the ability of virulent S. influenzae to kill mice is enhanced by suspending the organism in mucin. 2. The occurrence of a true infection characterized by in vivo multiplication of the organism has been established. 3. The necessity for using a pure inbred strain of mice for this type of study has been confirmed. 4. The increase in mucin virulence of a strain of H. influenzae by repeated passage through mice has been shown. 5. The usefulness of this method in passive immunization studies has been demonstrated.
Department of Bacteriology and Immunology, and the Department of Pediatrics, The Harvard Medical School, Boston.
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Fothergill
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Dingle
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Chandler