Usefulness of 16-row multidetector computed tomography with volume rendering and maximum intensity projection reconstruction as a monitor pancreatic graft vessel patency during the early postoperative period.
Thrombosis of the pancreatic graft vessels is the most common complication after transplantation. It leads to loss of 5% to 8% of grafts during the early postoperative period. The aims of this study were to evaluate the usefulness of 16-row multidetector computed tomography (16-MDCT) with volume rendering (VR) and maximum intensity projection (MIP) reconstruction to monitor pancreatic graft vessel patency during the early postoperative period and the efficacy of a heparin infusion as a treatment for graft thrombosis. Among 40 consecutive simultaneous pancreas-kidney transplant recipients, 16-MDCT was performed at 6 to 8 days after the operation. Secondary reconstructions were obtained with VR and MIP algorithms to evaluate the morphology and patency of the extra- and intrapancreatic arteries and veins. In cases of thrombosis, every patient was treated with an infusion of unfractionated heparin. In 15 recipients, thrombosis of the large vessels was detected by 16-MDCT. Heparin infusions saved five pancreatic grafts (5/15; 33.3%), but the other 10 pancreatic grafts were removed. In another four recipients (4/40; 10%) the thrombi were localized only in small intrapancreatic vessels. Treatment with heparin infusion was successful in 3/4 (75%) cases with patent vessels upon control computed tomography examination. We compared the efficacy of heparin treatment depending on the diameter of the thrombosed vessel, observing a significant difference (5/15 vs 3/4; P < .01; chi-square). 16-MDCT with secondary reconstruction by application of VR and MIP algorithms was an efficient method to visualize not only large pancreatic graft arteries and veins but also intrapancreatic parenchymal vessels. In cases of thrombosis of small intrapancreatic vessels, unfractionated heparin infusion significantly decreased graft loss.
Second Department of Radiology, Medical University of Warsaw, Warsaw, Poland.
L
L
Grabowska-Derlatka
T
T
Grochowiecki
T
T
Jakimowicz
R
R
Pacho
O
O
Rowiński
D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D016030:Kidney Transplantation / Q000473:pathology*; D016035:Pancreas Transplantation / Q000473:pathology*; D011184:Postoperative Period; D013927:Thrombosis / Q000453:epidemiology; D014057:Tomography, X-Ray Computed / Q000379:methods*; D017211:Treatment Failure; D014654:Vascular Patency / Q000187:drug effects
D006493:Heparin