Preliminary report: hepatic fat and inflammation in type 2 diabetes mellitus.
Although the association between inflammation and hepatic fat is fairly established, it remains unclear whether this association is independent of general measures of obesity and standard cardiovascular risk factors. Therefore, the aim of this study was to investigate the contribution of hepatic steatosis as an independent predictor of chronic inflammation in 281 subjects with type 2 diabetes mellitus. Reduced hepatic steatosis significantly (P < .01) correlated with C-reactive protein (r = -0.16) and adiponectin (r = 0.23). The association of hepatic steatosis with both C-reactive protein and adiponectin remained significant after adjustment for age, ethnicity, body mass index (or waist circumference), triglycerides, high-density lipoprotein, and total cholesterol. These data support the concept that accumulation of hepatic fat is related to enhanced inflammation in type 2 diabetes mellitus independent of general measures of obesity and standard cardiovascular risk factors.
Phoenix VA Health Care System, Phoenix, AZ 85012-1892, USA.
Aramesh
A
Saremi
Matthew
M
Allison
Dominic
D
Ditomasso
Ling
L
Ge
Robert
R
Anderson
Tom E
TE
Moritz
William
W
Duckworth
Carlos
C
Abraira
Peter D
PD
Reaven
D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000473:pathology*; D000328:Adult; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000473:pathology*; D005234:Fatty Liver / Q000209:etiology / Q000473:pathology; D005260:Female; D006505:Hepatitis / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D050356:Lipid Metabolism / Q000502:physiology; D008055:Lipids / Q000097:blood; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000473:pathology; D012307:Risk Factors
D052242:Adiponectin; D015850:Interleukin-6; D008055:Lipids; D002097:C-Reactive Protein