Marine-derived metabolites of S-adenosylmethionine as templates for new anti-infectives.
S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homoserine lactones. Marine organisms produce numerous AdoMet metabolites whose novel structures can be regarded as lead compounds for anti-infective drug design.
Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York, NY, USA.
Janice R
JR
Sufrin
Steven
S
Finckbeiner
Colin M
CM
Oliver
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000378:metabolism; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D008386:Marine Biology; D053038:Quorum Sensing; D012436:S-Adenosylmethionine / Q000378:metabolism*; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D001688:Biological Products; D012436:S-Adenosylmethionine