Micafungin - the newest echinocandin.
Micafungin is one of three currently FDA-approved echinocandins. It has potent in vitro activity against Candida species including non-albicans Candida and azole-resistant Candida species and has also demonstrated clinical efficacy against deep-seated Candida infections. Additional in vitro data and preliminary clinical efficacy studies suggest that it also has utility for the treatment of infections caused by Aspergillus species. However, its approved indications remain for the treatment of both invasive and esophageal candidiasis and for the prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation. is generally well tolerated with few significant adverse effects.
Mayo Clinic and Foundation, Division of Infectious Diseases, Rochester, MN 55905, USA. temesgen.zelalem@mayo.edu
Zelalem
Z
Temesgen
Jason
J
Barreto
Sandro
S
Vento
D000818:Animals; D000935:Antifungal Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D054714:Echinocandins / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D055666:Lipopeptides / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D000077551:Micafungin
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin