Association of body mass index and insulin resistance with metabolic syndrome in Brazilian children.
BACKGROUND
The clustering of cardiovascular risk factors called metabolic syndrome occurs in both children and adults. Insulin resistance and obesity are usual parts of the picture, but their joint effects on the onset of the syndrome remains somewhat debatable.


OBJECTIVE
The purpose of the current study was to examine the relationship of the body mass index (BMI) and insulin resistance with the metabolic syndrome (MS) in children.


METHODS
We studied 109 children, 55 boys and 54 girls, between 7 and 11 years of age (55 obese, 23 overweight and 31 controls). The weight status of each child was defined based on BMI/age ratio. Blood glucose, HDL, triglycerides and insulin were measured using fasting samples. Blood pressure was measured twice. The metabolic syndrome was defined according to the NCEP ATP III criteria.


RESULTS
The diagnosis of the MS was only found in obese children. The greater frequency of MS and of many of its components have been found in the children classified above the third quartile of the HOMA index, which is consistent with an association between insulin resistance and cardiovascular risk factors among the Brazilian children.


CONCLUSIONS
The present study shows that obesity and insulin resistance are likely to play a role in the development of cardiovascular risk factors in children since the prevalence of classic risk factors was higher in the upper BMI and HOMA percentiles.
Universidade Paulista - UNIP, Distrito Federal - Brasil.
Aparecido Pimentel
AP
Ferreira
Otávio de Tolêdo
Ode T
Nóbrega
Nancí Maria de
NM
França
D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D002648:Child; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism*; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism; D012016:Reference Values; D012307:Risk Factors