Linking inflammation to natural killer T cell activation.
Immune activation is often associated with inflammation, but inflammation's role in the expansion of antigen-specific immune responses remains unclear. This primer focuses on recent findings that show how specific natural killer T cells are activated by inflammatory messengers, thus illuminating the cellular and molecular links between immunity and inflammation.
Nuffield Department of Clinical Medicine, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Mariolina
M
Salio
Vincenzo
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Cerundolo
D000818:Animals; D017951:Antigen Presentation; D055610:Antigens, CD1d / Q000276:immunology; D015551:Autoimmunity; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D008213:Lymphocyte Activation; D008244:Lysophosphatidylcholines / Q000276:immunology; D055611:Natural Killer T-Cells / Q000276:immunology*
D055610:Antigens, CD1d; D008244:Lysophosphatidylcholines