The capsule drug device: novel approach for drug delivery to the eye.
Treatment of age-macular degeneration requires monthly intravitreal injections, which are costly and have serious risks. The objective of this study was to develop a novel intraocular implant for drug delivery. The capsule drug ring is a reservoir inserted in the lens capsule during cataract surgery, refillable and capable of delivering multiple drugs. Avastin was the drug of interest in this study. Prototypes were manufactured using polymethylmethacrylate sheets as the reservoir material, a semi-permeable membrane for controlled delivery and silicone check valves for refilling. The device showed near zero-order release kinetics and Avastin stability was investigated with accelerated temperature studies.
Department of Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA. s.a.molokhia@utah.edu
Sarah A
SA
Molokhia
Himanshu
H
Sant
Jacquelyn
J
Simonis
C J
CJ
Bishop
R M
RM
Burr
Bruce K
BK
Gale
Balamurali K
BK
Ambati
D020533:Angiogenesis Inhibitors / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000493:pharmacokinetics; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D004343:Drug Implants / Q000592:standards*; D006801:Humans; D008268:Macular Degeneration / Q000188:drug therapy*; D008422:Materials Testing; D010539:Permeability
D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D004343:Drug Implants; D000068258:Bevacizumab