International consensus report on the investigation and management of primary immune thrombocytopenia.
Previously published guidelines for the diagnosis and management of primary immune thrombocytopenia (ITP) require updating largely due to the introduction of new classes of therapeutic agents, and a greater understanding of the disease pathophysiology. However, treatment-related decisions still remain principally dependent on clinical expertise or patient preference rather than high-quality clinical trial evidence. This consensus document aims to report on new data and provide consensus-based recommendations relating to diagnosis and treatment of ITP in adults, in children, and during pregnancy. The inclusion of summary tables within this document, supported by information tables in the online appendices, is intended to aid in clinical decision making.
Provan
Drew
D
Department of Haematology, Barts and The London School of Medicine and Dentistry, London, United Kingdom. a.b.provan@qmul.ac.uk
Stasi
Roberto
R
Newland
Adrian C
AC
Blanchette
Victor S
VS
Bolton-Maggs
Paula
P
Bussel
James B
JB
Chong
Beng H
BH
Cines
Douglas B
DB
Gernsheimer
Terry B
TB
Godeau
Bertrand
B
Grainger
John
J
Greer
Ian
I
Hunt
Beverley J
BJ
Imbach
Paul A
PA
Lyons
Gordon
G
McMillan
Robert
R
Rodeghiero
Francesco
F
Sanz
Miguel A
MA
Tarantino
Michael
M
Watson
Shirley
S
Young
Joan
J
Kuter
David J
DJ
D000328:Adult; D002648:Child; D002675:Child, Preschool; D032921:Consensus; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology