Prognostic value of serum tumor antigen CA19-9 after curative resection of colorectal cancer.
BACKGROUND
CA19-9 was evaluated as a prognostic marker for colorectal cancer and whether it could be helpful in addition to surveillance using CEA was also tested.


METHODS
Serum CA19-9 levels were measured preoperatively in 1109 patients and monitored at 3-month intervals for the first 2 years postoperatively, and at 6-month intervals thereafter in 700 patients.


RESULTS
Preoperative high CA19-9 was independent prognostic factor for recurrence. Among patients with recurrence, 21.4% had a high postoperative CA19-9. High postoperative CA 19-9 levels were more likely in patients with high preoperative levels. Postoperative CA19-9 increased more in patients with a peritoneal recurrence than in those with liver metastasis (p=0.002). Among patients with recurrence, CA19-9 increased in 7.8% of the patients with a normal follow-up CEA.


CONCLUSIONS
Postoperative CA19-9 was more frequently elevated when peritoneal recurrence occurred. Data on CA19-9 levels provided 7.8% of additional information in predicting recurrence in this study.
Park
In Ja
IJ
Department of Surgery, School of Medicine, Kyungpook National University 50 Samduk-dong 2ga Jung-gu, Daegu, Korea.
Choi
Gyu-Seog
GS
Jun
Soo Han
SH
D018395:CA-19-9 Antigen / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000473:pathology; D009367:Neoplasm Staging; D011184:Postoperative Period; D057234:Preoperative Period
D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen