CICATRIZATION OF WOUNDS : II. MATHEMATICAL EXPRESSION OF THE CURVE REPRESENTING CICATRIZATION.
The cicatrization of sterile wounds may be studied in the same way as an ordinary physicochemical phenomenon. It is possible, therefore, to express the law of cicatrization by a mathematical equation as soon as an accurate measure of the wound can be obtained. By means of the equation, a curve is obtained which represents the theoretical evolution of the cicatrization of a wound. This curve, being an expression of what should happen on a normal wound, healing aseptically, on a normal man, is a daily point of comparison to what appears actually on the observed wound, and allows one to study accurately the fluctuations of cicatrization on a given individual, and the action of different dressings and antiseptic substances.
Du Noüy
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Laboratories of The Rockefeller Institute for Medical Research, New York, and Hospital 21, Compiègne, France.