Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.
In Alzheimer's disease, microglia cluster around beta-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application. Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic dystrophy depended on the presence of microglia.
Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Stefan A
SA
Grathwohl
Roland E
RE
Kälin
Tristan
T
Bolmont
Stefan
S
Prokop
Georg
G
Winkelmann
Stephan A
SA
Kaeser
Jörg
J
Odenthal
Rebecca
R
Radde
Therese
T
Eldh
Sam
S
Gandy
Adriano
A
Aguzzi
Matthias
M
Staufenbiel
Paul M
PM
Mathews
Hartwig
H
Wolburg
Frank L
FL
Heppner
Mathias
M
Jucker
D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D000998:Antiviral Agents / Q000009:adverse effects / Q000494:pharmacology; D039481:CD11b Antigen / Q000235:genetics*; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D015774:Ganciclovir / Q000009:adverse effects / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics; D049452:Green Fluorescent Proteins / Q000235:genetics; D006801:Humans; D007270:Injections, Intra-Articular / Q000379:methods; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D017628:Microglia / Q000187:drug effects / Q000502:physiology*; D016253:Microscopy, Immunoelectron / Q000379:methods; D009154:Mutation; D019150:Neuroaxonal Dystrophies / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D010930:Plague / Q000473:pathology*; D053764:Presenilin-1 / Q000235:genetics; D013937:Thymidine Kinase / Q000235:genetics; D000097382:CD68 Molecule
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000998:Antiviral Agents; D039481:CD11b Antigen; D015774:Ganciclovir; D049452:Green Fluorescent Proteins; D053764:Presenilin-1; D013937:Thymidine Kinase; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C485184:enhanced green fluorescent protein