Genetic testing of the hypothesis that hybrid male lethality results from a failure in dosage compensation.
Several recent studies have suggested that F(1) hybrid male lethality in crosses between Drosophila melanogaster and D. simulans is due to a failure in dosage compensation, caused by incompatibilities between D. simulans dosage compensation proteins and the D. melanogaster X chromosome. Contrary to the predictions of this hypothesis, mutations in four essential D. melanogaster dosage compensation genes are shown here to moderately increase rather than decrease hybrid male viability.
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. dab87@cornell.edu
Daniel A
DA
Barbash
D000818:Animals; D003433:Crosses, Genetic; D003643:Death; D004303:Dosage Compensation, Genetic / Q000235:genetics*; D004331:Drosophila melanogaster / Q000145:classification / Q000235:genetics* / Q000502:physiology*; D005260:Female; D006824:Hybridization, Genetic / Q000235:genetics*; D008297:Male; D008957:Models, Genetic; D009154:Mutation; D015203:Reproducibility of Results; D014960:X Chromosome / Q000235:genetics