Excavatoids E and F: discovery of two new briaranes from the cultured octocoral Briareum excavatum.
Two new briarane-related diterpenoids, designated as excavatoids E (1) and F (2), were isolated from the cultured octocoral Briareum excavatum. The structures of compounds 1 and 2 were established on the basis of extensive spectral data analysis. Briaranes 1 and 2 were found to exhibit moderate inhibitory effects on elastase release by human neutrophils.
Sung
Ping-Jyun
PJ
Graduate Institute of Marine Biotechnology and Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Checheng, Pingtung 944, Taiwan.
Chen
Bo-Yuan
BY
Lin
Mei-Ru
MR
Hwang
Tsong-Long
TL
Wang
Wei-Hsien
WH
Sheu
Jyh-Horng
JH
Wu
Yang-Chang
YC
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010196:Pancreatic Elastase / Q000187:drug effects / Q000378:metabolism; D013057:Spectrum Analysis; D013624:Taiwan
D004224:Diterpenes; C546722:excavatoid E; C546723:excavatoid F; D010196:Pancreatic Elastase