Differences in physicians' self-reported knowledge of, attitudes toward, and responses to the black box warning on long-acting beta-agonists.
BACKGROUND
Inhaled corticosteroids and long-acting beta-agonists (LABAs) are recommended for treating moderate to severe persistent asthma. The Food and Drug Administration has issued a black box warning (BBW) for LABAs.


OBJECTIVE
To investigate physician knowledge of the BBW and its effect on the practice of specialists (pulmonologists and allergists) and primary care physicians (PCPs) (internists and family physicians).


METHODS
A total of 1,107 physicians responded to a questionnaire to determine their awareness of the BBW and whether it changed their practice.


RESULTS
The group comprised 429 pulmonologists (38.8%), 395 allergists (35.7%), 141 internists (12.7%), 132 family physicians (11.9%), and 10 pediatricians (0.9%). Comparing specialists with PCPs, there was approximately a 10% difference in the rate of knowledge concerning the BBW (99.0% vs 90.8%, P < .001). Approximately a quarter of specialists agreed with the BBW compared with 52.9% of family physicians and 40.3% of internists. Twice as many PCPs vs specialists agreed with the warning (45.6% vs 24.2%, P < .001). The PCPs were more likely to alter their prescribing habits than were specialists (40.1% vs 34.6%, P < .005). Specialists were more likely to discuss the warning with patients than were PCPs (87.4% vs 64.8%, P < .001). For mild persistent asthma, most respondents chose inhaled corticosteroids as the preferred first-line therapy, but 11.4% of PCPs and 2.1% of specialists identified LABA monotherapy as their first choice. For moderate to severe asthma, the pattern of response was similar.


CONCLUSIONS
Although most physicians were aware of the BBW for LABAs, there was a difference in how specialists and PCPs approached it and altered their prescribing habits.
Division of Pulmonary and Critical Care Medicine, North Shore University Hospital, Manhasset, New York, USA. jpkarpel@aol.com
Jill P
JP
Karpel
Jay I
JI
Peters
Anthony M
AM
Szema
Brad
B
Smith
Paula J
PJ
Anderson
D000318:Adrenergic beta-Agonists / Q000008:administration & dosage* / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy*; D004348:Drug Labeling; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D010820:Physicians; D010818:Practice Patterns, Physicians'; D012650:Self Disclosure; D014481:United States; D014486:United States Food and Drug Administration
D000318:Adrenergic beta-Agonists