[Oxidative stress and trace elements affect the activity of sodium transporting systems in a cellular membrane of a erythrocyte].
We examined the activity of sodium transporting systems (STS) in a cellular membrane of erythrocytes in a group of 21 patients under chronic hemodialysis treatment with the dialyzing fluid containing glucose HD-g(+), and 22 patients dialysed with the fluid not containing glucose HD-g(-), 21 patients with chronic kidney failure already not treated with dialysis and 21 control group. We examined the concentration of antioxidative system cofactors, such as zinc, copper and selenium in erythrocytes and plasma. The marker of oxidative stress in erythrocytes and plasma was the concentration of TBARS. Among all STS we examined the activity of Na(+)/K(+) ATP-ase, Na(+)/K(+)/Cl(-); co-transport, Na(+)/Li(+) exchanger, Na(+), K(+)-outflow. Copper zinc and selenium as cofactors of antioxidative enzymes may reflect the antioxidative processes inside the organism undergoing the influence of free radicals.
Klinika Nefrologii, Transplantologii i Chorób Wewnetrznych Pomorskiej Akademii Medycznej w Szczecinie, Szczecin.
Karolina
K
Kedzierska
Joanna
J
Bober
Ewa
E
Kwiatkowska
Ewa
E
Stachowska
Maria
M
Olszewska
Dariusz
D
Chlubek
Kazimierz
K
Ciechanowski
D000368:Aged; D003300:Copper / Q000097:blood; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D017136:Ion Transport; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D018384:Oxidative Stress; D006435:Renal Dialysis; D012643:Selenium / Q000097:blood; D012964:Sodium / Q000097:blood*; D014131:Trace Elements / Q000097:blood*; D015032:Zinc / Q000097:blood
D014131:Trace Elements; D003300:Copper; D012964:Sodium; D012643:Selenium; D015032:Zinc