Acute kidney injury after on-pump coronary artery bypass graft surgery.
BACKGROUND
The acute kidney injury (AKI) is a complex disease for which there is no accepted standard definition nowadays. The Acute Kidney Injury Network (AKIN) represents an attempt to standardize the criteria for diagnosis and staging of acute renal dysfunction based on recently published RIFLE criteria, that means, (Risk, Injury, Failure, Loss, and End-stage kidney disease).


OBJECTIVE
To evaluate the incidence and associated mortality of AKI in patients submitted to on-pump coronary artery bypass graft surgery (on-pump CABG).


METHODS
A total of 817 patients were divided into two groups: negative AKI (-), with 421 patients (51.5%), and positive AKI (+), with 396 patients (48.5%). Increase of 0.3 mg/dL in creatinine or of 50% in creatinine's basal value was considered as AKI.


RESULTS
The rate of patient's mortality with or without AKI within 30 days after cardiac surgery was 12.6% and 1.4%, respectively (p<0.0001). In a multivariate logistic regression model, AKI after on-pump CABG was an independent predictor of death within 30 days (OR=6.7; p=0.0002). This group of patients presented a longer period of permanency in intensive care unit (ICU) [median 2 days (2 to 3) versus 3 days (2 to 5); p=0.0001] and a bigger proportion of patients with prolonged permanence in intensive care (>14 days) (14 versus 2%; p=0.0001).


CONCLUSIONS
In the studied population, even a discrete alteration in renal function, based on AKIN criteria, was an independent predictor of death in 30 days after on-pump CABG.
Hospital de Base da Faculdade de Medicina de São José do Rio Preto-FAMERP, Rua José Elias Abud 242, São José do Rio Preto, SP, Brazil. nassau@cardiol.br
Maurício de Nassau
MN
Machado
Rafael Carlos
RC
Miranda
Isabela Thomaz
IT
Takakura
Eduardo
E
Palmegiani
Carlos Alberto dos
CA
Santos
Marcos Aurélio
MA
Oliveira
Osana M
OM
Mouco
Mauro E
ME
Hernandes
Maria Angélica
MA
Lemos
Lília N
LN
Maia
D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology / Q000401:mortality*; D001938:Brazil / Q000453:epidemiology; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged
D003404:Creatinine