CTX-M-2-producing Salmonella Typhimurium isolated from pediatric patients and poultry in Brazil.
Ten Salmonella enterica serovar Typhimurium isolates producing CTX-M-2 extended-spectrum beta-lactamase were identified from clinical and poultry sources in two distant cities in Brazil between 2003 and 2004. They included two isolates from pediatric patients and eight isolates from poultry or its environment. All isolates exhibited coresistance to non-beta-lactam antimicrobials including tetracycline and trimethoprim/sulfamethoxazole. The CTX-M-2 gene was located on transferable plasmids with sizes between 90 and 170 kb that also carried other resistance determinants in some isolates. By pulsed-field gel electrophoresis, the genetic similarity of the isolates including clinical and poultry ones ranged from 89% to 100%.
Adolfo Lutz Institute, São Paulo, Brazil.
Sueli A
SA
Fernandes
David L
DL
Paterson
Angela C
AC
Ghilardi-Rodrigues
Jennifer M
JM
Adams-Haduch
Ana T
AT
Tavechio
Yohei
Y
Doi
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001938:Brazil / Q000453:epidemiology; D002648:Child; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D008826:Microbial Sensitivity Tests; D011200:Poultry; D011201:Poultry Diseases / Q000382:microbiology; D012480:Salmonella Infections / Q000382:microbiology*; D012481:Salmonella Infections, Animal / Q000382:microbiology*; D019779:Salmonella enterica / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D001618:beta-Lactamases / Q000235:genetics*
D000900:Anti-Bacterial Agents; C071167:beta-lactamase CTX-2; D001618:beta-Lactamases