Bipolar hypertrophic herpes: an unusual presentation of acyclovir-resistant herpes simplex type 2 in a HIV-infected patient.
Hypertrophic pseudo tumoral herpetic lesion is an uncommon presentation in immunocompromized hosts that can be refractory to established therapies. We describe bipolar anal and tonsilar herpetic tumoral lesions related to acyclovir-resistant HSV-2 in a human immunodeficiency virus-infected patient. Treatment with valacyclovir, cidofovir, and thalidomide failed and surgical excision was required.
Cury
Karine
K
Service des Maladies Infectieuses et Tropicales, hôpital Saint Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France.
Valin
Nadia
N
Gozlan
Joël
J
Jacquier
Isabelle
I
Boutolleau
David
D
Guegan
Sarah
S
Flejou
Jean François
JF
Girard
Pierre Marie
PM
D000212:Acyclovir / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001004:Anus Diseases / Q000150:complications / Q000188:drug therapy / Q000601:surgery / Q000821:virology; D002522:Chlorocebus aethiops; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000150:complications*; D006561:Herpes Simplex / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000821:virology; D018258:Herpesvirus 2, Human / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D006984:Hypertrophy; D008297:Male; D008875:Middle Aged; D014066:Palatine Tonsil / Q000473:pathology / Q000821:virology; D010608:Pharyngeal Diseases / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000821:virology; D014709:Vero Cells
D000998:Antiviral Agents; D000212:Acyclovir