[Clinical significance of some genetic polymorphisms of cytochrome P-450 subfamilies CYP2D, CYP2E and CYP3A--part II].
Polymorphism of drugs biotransformation is clinically significant from the point of view of the effectiveness and safety of pharmacotherapy and an increased risk of some illnesses. The paper presents molecular mechanisms and clinical implication of several genetic polymorphisms of cytochrome P-450 (CYP) xenobiotics metabolizing enzymes and genetic predisposition to the occurrence of some diseases.
Wojtczak
Anna
A
Medical University of Łódź, Department of Pharmacogenetics, Poland. awojt@mp.pl
Skretkowicz
Jadwiga
J
D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D015262:Xenobiotics / Q000494:pharmacology
D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System