THE FATE OF ORALLY ADMINISTERED SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS TYPES I, II AND III.
1. Rats, when fed the soluble specific substance of Types I, II and III pneumococcus, excrete a very large proportion in the feces. 2. Following ingestion of these substances, tests sensitive enough to detect 1 part in 2,000,000 of serum, and 1 part in 3,000,000 of urine, were negative. 3. The polysaccharide of Type I, when recovered from the feces, is as active an immunizing agent as it was originally.
Ross
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Department of Biological Chemistry, College of Physicians and Surgeons, Columbia University, and the Bureau of Laboratories, Department of Health of the City of New York, New York.