Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine.
In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R(+/+)), both heterozygous (D4R(+/-)) and knockout (D4R(-/-)) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.
Thanos
Panayotis K
PK
Laboratory of Neuroimaging, NIAAA, NIH, Bethesda, MD, USA. thanos@bnl.gov
Habibi
Rahila
R
Michaelides
Michael
M
Patel
Ujval B
UB
Suchland
Katherine
K
Anderson
Brenda J
BJ
Robinson
John K
JK
Wang
Gene-Jack
GJ
Grandy
David K
DK
Volkow
Nora D
ND
D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects* / Q000502:physiology*; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D005502:Food; D006579:Heterozygote; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D050638:Receptors, Dopamine D4 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D012646:Self Administration
D018765:Dopamine Uptake Inhibitors; D050638:Receptors, Dopamine D4; D003042:Cocaine