Somatosensory function in asymptomatic Parkin-mutation carriers.
OBJECTIVE
It is a matter of debate whether somatosensory abnormalities in Parkinson's disease (PD) precede or follow PD motor signs and whether they are of central or peripheral origin. The sensory sural nerve action potential amplitude (SNAP) was previously reported to be reduced in symptomatic Parkin-associated PD. The aim of our study was to investigate asymptomatic Parkin-mutation carriers to elucidate whether putative somatosensory abnormalities precede motor symptoms therewith helping to determine the origin of somatosensory signs.


METHODS
Nine subjects with Parkin-mutations and nine healthy controls were examined clinically, with quantitative sensory testing (QST) and neurography.


RESULTS
There was a higher frequency of cold pain threshold abnormalities and hypofunction of Abeta-fibres/central afferent pathways in Parkin-mutation carriers compared to controls. Neurography of Parkin-mutation carriers did not indicate peripheral neuropathy.


CONCLUSIONS
Sensory abnormalities of asymptomatic Parkin-mutation carriers as obtained by QST suggest impairment of either small and large peripheral pathways or central somatosensory processing. In contrast to Parkin-associated PD, asymptomatic Parkin-mutation carriers do not show a reduced SNAP.
Division of Neurological Pain Research and Therapy, Department of Neurology, University of Kiel, Kiel, Germany. j.gierthmuehlen@neurologie.uni-kiel.de
J
J
Gierthmühlen
S
S
Schumacher
G
G
Deuschl
E
E
Fritzer
C
C
Klein
R
R
Baron
C
C
Helmchen
D000200:Action Potentials; D000328:Adult; D000344:Afferent Pathways / Q000166:cytology / Q000502:physiology; D016022:Case-Control Studies; D003080:Cold Temperature; D005260:Female; D005528:Foot / Q000502:physiology; D006225:Hand / Q000502:physiology; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009431:Neural Conduction; D010146:Pain / Q000235:genetics / Q000503:physiopathology; D017288:Pain Threshold / Q000502:physiology; D010543:Peroneal Nerve / Q000502:physiology; D010641:Phenotype; D012677:Sensation / Q000235:genetics* / Q000502:physiology*; D013497:Sural Nerve / Q000502:physiology; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
D044767:Ubiquitin-Protein Ligases; C111567:parkin protein