ERK and cell death: ERK location and T cell selection.
The selection of functional T cells is mediated by interactions between the T cell antigen receptor and self-peptide major histocompatibility complex expressed on thymic epithelium. These interactions either lead to survival and development or death. The T cell antigen receptor is an unusual receptor able to signal multiple cell fates. The precise mechanism by which this is achieved has been an area of intense research effort over the years. One model proposes that the differential activation of mitogen-activated protein kinase pathways contributes to this decision. Here, the role of extracellular signal-regulated kinase in promoting or preventing apoptosis during thymic selection is discussed.
Department of Molecular Microbiology and Immunology, Center for Cellular and Molecular Immunology, School of Medicine, University of Missouri, Columbia, MO 65212, USA.
Emma
E
Teixeiro
Mark A
MA
Daniels
D048868:Adaptor Proteins, Signal Transducing / Q000276:immunology; D000818:Animals; D017209:Apoptosis / Q000276:immunology / Q000502:physiology; D016923:Cell Death / Q000276:immunology* / Q000502:physiology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000276:immunology* / Q000502:physiology*; D006801:Humans; D020935:MAP Kinase Signaling System / Q000276:immunology; D048054:Mitogen-Activated Protein Kinase 7 / Q000276:immunology / Q000502:physiology; D018448:Models, Immunological; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1 / Q000276:immunology / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology* / Q000201:enzymology / Q000276:immunology*
D048868:Adaptor Proteins, Signal Transducing; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D011948:Receptors, Antigen, T-Cell; D048049:Extracellular Signal-Regulated MAP Kinases; D048054:Mitogen-Activated Protein Kinase 7