Two subgroups of schizophrenia identified by systematic cognitive neuropsychiatric mapping.
The description of the heterogeneous phenomenological, pathophysiological, and etiological nature of schizophrenia is under way; however, the relationships between heterogeneity levels are still unclear. We performed a robust cross-sectional study, including a systematic neuropsychological battery, assessment of clinical symptoms, neurological soft signs, morphogenetic anomalies and smell identification, and measurement of event-related potentials on 50 outpatients with schizophrenia in their compensated states. An explorative fuzzy cluster analysis revealed two subgroups in this sample that could be distinguished from each other on symptomatological, cognitive and neurological levels. The patterns of cognitive dysfunctions and neurological developmental anomalies equally indicate that there may be hemispherical differences between the patients belonging to the different clusters.
Szendi
István
I
Department of Psychiatry, University of Szeged, 6 Semmelweis str., 6725, Szeged, Hungary. szendi@nepsy.szote.u-szeged.hu
Racsmány
Mihály
M
Cimmer
Csongor
C
Csifcsák
Gábor
G
Kovács
Zoltán Ambrus
ZA
Szekeres
György
G
Galsi
Gabriella
G
Tóth
Ferenc
F
Nagy
Attila
A
Garab
Edit Anna
EA
Boda
Krisztina
K
Gulyás
Gergely
G
Kiss
József Géza
JG
Dombi
József
J
Pléh
Csaba
C
Janka
Zoltán
Z
D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000465:Algorithms; D016000:Cluster Analysis; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology; D003265:Contingent Negative Variation / Q000502:physiology; D004569:Electroencephalography / Q000379:methods; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D011336:Probability; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000145:classification / Q000150:complications / Q000175:diagnosis; D012565:Schizophrenic Psychology; D012903:Smell / Q000502:physiology; D018709:Statistics, Nonparametric; D055815:Young Adult