Epithelial-mesenchymal transition in mouse mammary tumorigenesis.
Epithelial-mesenchymal transition tumorigenesis in the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms. Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.
Radaelli
Enrico
E
Department of Veterinary Pathology, Hygiene and Public Health, Section of Veterinary and Avian Pathology, Faculty of Veterinary Medicine, University of Milan, Via Celoria, 10 20133 Milano, Italy.
Damonte
Patrizia
P
Cardiff
Robert D
RD
D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology; D002454:Cell Differentiation / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D004848:Epithelium / Q000473:pathology*; D005260:Female; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000473:pathology*; D008648:Mesoderm / Q000473:pathology*; D008679:Metaplasia; D051379:Mice