Glaucoma diagnostic performance of humphrey matrix and standard automated perimetry.
OBJECTIVE
To evaluate and compare the performance of Humphrey Matrix perimetry (Matrix) and standard automated perimetry (SAP) for glaucoma discrimination.


METHODS
Forty-seven healthy and 68 glaucomatous subjects were included in this study. Glaucoma was defined as having a glaucomatous optic disc and a nerve fiber indicator (NFI) GDx VCC scanning laser polarimetry score of >40. Glaucomatous subjects were classified into two groups, early (40 < NFI < or = 50) and moderate to advanced (NFI > 50). The number of clusters on Matrix and SAP pattern deviation maps were estimated and scored. Areas under the receiver operating characteristic curves (AUCs) of the cluster scores were calculated for early and moderate to advanced stages of glaucoma and compared between Matrix and SAP.


RESULTS
Among 68 glaucomatous subjects, 24 eyes were classified as having early and 44 eyes as having moderate to advanced glaucoma. The overall AUC of the Matrix cluster score was comparable to that of SAP (0.857, 0.881, P = 0.538). The AUC of the cluster score did not reveal statistically significant differences between Matrix and SAP for either early or moderate to advanced stages of glaucoma (P = 0.831, 0.237).


CONCLUSIONS
Both Matrix and SAP showed good diagnostic performance with glaucoma defined as structural loss. Matrix and SAP data showed similar discrimination capability for different stages of glaucoma determined by cluster analysis.
Department of Ophthalmology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea.
Yoon Pyo
YP
Nam
Seong Bae
SB
Park
Sung Yong
SY
Kang
Kyung Rim
KR
Sung
Michael S
MS
Kook
D019540:Area Under Curve; D005189:False Positive Reactions; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D057066:Low Tension Glaucoma / Q000175:diagnosis*; D008297:Male; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012372:ROC Curve; D014786:Vision Disorders / Q000175:diagnosis*; D058609:Visual Field Tests / Q000592:standards*; D014794:Visual Fields