[Liver, kidney and a lung structure in rats after intravenous magnetoliposome administration].
This work examines the effect of magnetoliposomes on the basis of Fe3O4 nanoparticles following different time intervals after their single intravenous injection, on the liver, kidney and lung structure in rats. Sections were stained with hematoxylin and eosin, and Perls method was used to demonstrate Fe+3 ions. It was shown that shortly after intravenous injection of magnetoliposomes, hemodynamic disturbances developed in all the organs studied, which by day 14 were aggrevated by focal necroses and dystrophic changes in the liver and kidneys. Accumulation of nanoparticles in the cells of mononuclear phagocyte system of these organs was demonstrated. Damaging effect of magnetoliposomes on liver, kidney and a lung structure was established, which was caused by ultradisperse Fe3O4 particles contained in them. The consequences of this influence for the rat organism at the time periods exceeding the duration of our experiment, may hardly be predicted.
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D000818:Animals; D005290:Ferric Compounds / Q000008:administration & dosage / Q000009:adverse effects; D007275:Injections, Intravenous; D007668:Kidney / Q000473:pathology*; D008081:Liposomes / Q000009:adverse effects* / Q000494:pharmacology; D008099:Liver / Q000473:pathology*; D008168:Lung / Q000473:pathology*; D008280:Magnetics; D053758:Nanoparticles / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats
D005290:Ferric Compounds; D008081:Liposomes; C000499:ferric oxide