[Female patient with type 2 diabetes in coma with metabolic acidosis].
In case of impaired consciousness, metabolic acidosis with wide anion gap and elevated lactate levels a metformin associated lactic acidosis should be considered in diabetic patients. Taking into account the contraindications to metformin, lactic acidosis is a rare complication, however - if it occurs - fatal in 50-80%. The outcome of the surviving patients is good, once the acute stage is outlived due to immediate hemofiltration.
zur Nieden
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Medizinische Klinik, Diakonie-Klinikum Stuttgart, Akademisches Lehrkrankenhaus der Eberhard-Karls Universität Tübingen, Rosenbergstrasse 38, 70176, Stuttgart, Deutschland. nieden@diak-stuttgart.de
Conrad
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D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000175:diagnosis* / Q000517:prevention & control; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008687:Metformin / Q000009:adverse effects* / Q000627:therapeutic use*
D008687:Metformin