Comparison of the anorexigenic activity of CRF family peptides.
Corticotropin releasing factor (CRF) family peptides have an important role in the control of food intake. We investigated the effects of CRF family peptides on food intake and body weight gain in mice. Of the CRF family peptides, including CRF, urocortin1 (Ucn1), urocortin2 (Ucn2) and urocortin3 (Ucn3), peripherally administered Ucn1 was shown to have the most potent inhibitory effect on the food intake and body weight gain of both lean and high fat fed obese mice. In addition, repeated administration of Ucn1 lowered blood glucose and acylated ghrelin, and decreased the visceral fat weight of high fat fed obese mice.
Division of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan.
Chie
C
Tanaka
Akihiro
A
Asakawa
Miharu
M
Ushikai
Takeo
T
Sakoguchi
Haruka
H
Amitani
Mutsumi
M
Terashi
KaiChun
K
Cheng
Huhe
H
Chaolu
Norifumi
N
Nakamura
Akio
A
Inui
D000818:Animals; D001067:Appetite Depressants / Q000008:administration & dosage / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage; D004435:Eating / Q000187:drug effects; D054439:Ghrelin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D054832:Urocortins / Q000008:administration & dosage / Q000494:pharmacology*
D001067:Appetite Depressants; D004041:Dietary Fats; D054439:Ghrelin; D054832:Urocortins; D003346:Corticotropin-Releasing Hormone