Synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N'-(2-alkynylbenzylidene)hydrazides.
Diversity-oriented synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N'-(2-alkynylbenzylidene)hydrazide is described. Bromine-mediated electrophilic cyclization, Ag-catalyzed alkyne nucleophilic addition, and palladium-catalyzed cross-coupling reaction were involved in the transformation.
Chen
Zhiyuan
Z
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China.
Su
Mingchao
M
Yu
Xingxin
X
Wu
Jie
J
D000480:Alkynes / Q000737:chemistry; D000577:Amides / Q000737:chemistry; D001966:Bromine / Q000737:chemistry; D002384:Catalysis; D006834:Hydrazines / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry
D000480:Alkynes; D000577:Amides; D006834:Hydrazines; D007546:Isoquinolines; D010165:Palladium; D001966:Bromine