Outcome and prognostic factors on 57 cases of infective endocarditis in a single centre.
OBJECTIVE
We aim to evaluate the clinical characteristics and outcome of infective endocarditis in our hospital, and the prognostic significance of recurrent endocarditis.


METHODS
A single centre retrospective review of all cases of infective endocarditis (IE) was undertaken for a 5-year period from June 2002.


RESULTS
There were 57 episodes of IE in 47 patients. Seventy percent were definite IE using the modified Duke Criteria (2000). The most commonly isolated organisms were Streptococci (37%) and Staphylococcus aureus (35%). Forty-nine percent of patients remained event-free from death, recurrence, or operation at the end of follow-up period. Five cases (8.5%) had early recurrence of endocarditis within 60 days. Eleven patients (23%) died during follow-up (mean 14 months). There was no significant increase in mortality of patients with history of recurrent endocarditis (38% vs 28%; p=0.39). Staphylococcus aureus was associated with increased mortality or need for valve surgery (OR 4.5; 95%CI 1.38-14.8), risk of neurological events (OR 8.9; 1.5-52), renal failure (OR 7.2; 1.7-30) and thrombocytopenia (OR 5.6; 1.4-22).


CONCLUSIONS
The mortality of IE remains high. Less than half of this cohort remained event-free. The micro-organism involved is more predictive of mortality or need for surgery than recurrent endocarditis.
Wong
Chi Wing
CW
Department of Cardiology, Tauranga Hospital, Cameron Road, Private Bag 12024, Tauranga, New Zealand. kitwong@xtra.co.nz
Porter
Graeme
G
Tisch
Jonathan
J
Young
Calum
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001021:Aortic Valve / Q000601:surgery; D001705:Bioprosthesis / Q000382:microbiology; D015331:Cohort Studies; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D004452:Echocardiography; D004697:Endocarditis, Bacterial / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis / Q000382:microbiology; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D009520:New Zealand; D010138:Pacemaker, Artificial / Q000382:microbiology; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D013290:Streptococcal Infections / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D055815:Young Adult
D000900:Anti-Bacterial Agents