Antibacterial activity of 2-(2',4'-dibromophenoxy)-4,6-dibromophenol from Dysidea granulosa.
2-(2',4'-Dibromophenoxy)-4,6-dibromophenol isolated from the marine sponge Dysidea granulosa (Bergquist) collected off the coast of Lakshadweep islands, Indian Ocean, exhibited potent and broad spectrum in-vitro antibacterial activity, especially against methicillin resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA), vancomycin resistant Enterococci (VRE), vancomycin sensitive Enterococci (VSE) and Bacillus spp. Minimal inhibitory concentration (MIC) was evaluated against 57 clinical and standard strains of Gram positive and Gram negative bacteria. The observed MIC range was 0.117-2.5 microg/mL against all the Gram positive bacteria and 0.5-2 microg/mL against Gram negative bacteria. The in-vitro antibacterial activity observed was better than that of the standard antibiotic linezolid, a marketed anti-MRSA drug. The results establish 2-(2',4'-dibromophenoxy)-4,6-dibromophenol, as a potential lead molecule for anti-MRSA and anti-VRE drug development.
Bioorganic Chemistry, Chemical Oceanography Division, National Institute of Oceanography, Council of Scientific and Industrial Research (CSIR), Dona Paula, 403 004, Goa, India.
Divya M P
DM
Shridhar
Girish B
GB
Mahajan
Vijayendra P
VP
Kamat
Chandrakant G
CG
Naik
Rajashri R
RR
Parab
Nidhi R
NR
Thakur
Prabhu D
PD
Mishra
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D047088:Dysidea / Q000737:chemistry*; D016983:Enterococcus / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D019156:Indian Ocean; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010647:Phenyl Ethers / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D020713:Vancomycin Resistance
C546721:2-(2',4'-dibromophenoxy)-4,6-dibromophenol; D000900:Anti-Bacterial Agents; D010647:Phenyl Ethers