Development of antisynthetase syndrome in a patient with rheumatoid arthritis.
Rheumatoid arthritis (RA) and antisynthetase syndrome (ASS) are distinct clinical syndromes, and their co-occurrence is rarely encountered. The authors report the case of a 56-year-old female patient with RA of 3 years duration who suddenly developed ASS, and include a review of the literature. The patient was diagnosed with ASS based on; positivity for anti-histidyl-tRNA synthetase (Jo-1) antibody, interstitial lung disease, polyarthritis, and mechanic's hands. High-dose corticosteroid and pulse intravenous cyclophosphamide were used to control the ASS. This case demonstrates that ASS should be considered during clinical presentations due to its potential overlap with RA.
Park
Cheol-Kyu
CK
Department of Rheumatology, Chonnam National University Medical School and Hospital, 8 Hak-dong, Dong-ku, Gwangju 501-757, Republic of Korea.
Kim
Tae-Jong
TJ
Cho
Young-Nan
YN
Kim
Il-Soo
IS
Lee
Ho-Jun
HJ
Lee
Kyung-Eun
KE
Park
Seong-Chang
SC
Kim
Jong-Sun
JS
Park
Dong-Jin
DJ
Lee
Sung-Ji
SJ
Seo
Seong-Rye
SR
Kim
Jeong-Chul
JC
Song
Sang-Gook
SG
Lee
Shin-Seok
SS
Park
Yong-Wook
YW
D001172:Arthritis, Rheumatoid / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009220:Myositis / Q000188:drug therapy / Q000209:etiology