Seroprevalence of Bartonella henselae in patients with uveitis and healthy individuals in Tokyo.
OBJECTIVE
To compare the seroprevalence of Bartonella henselae, a pathogen of cat scratch disease, in patients with uveitis and in healthy individuals.


METHODS
Serum samples were collected from 197 consecutive patients with various entities of uveitis at Tokyo Medical and Dental University Hospital, and from 83 healthy age- and sex-matched volunteers. Anti-Bartonella IgG and IgM antibodies were examined by indirect immunofluorescent antibody.


RESULTS
Serum antibodies to B. henselae were positive in 39 of 197 (19.8%) patients with uveitis, and in 21 of 83 (25.3%) of the healthy volunteers. There was no statistical difference in the seroprevalence between the two groups. The overall seroprevalence of B. henselae was 60 of 280 (21.4%).


CONCLUSIONS
The seroprevalence of B. henselae was similar in both patients with uveitis and in healthy volunteers in Tokyo, Japan. These data indicate that a significant number of healthy individuals are asymptomatic carriers of B. henselae, which should be kept in mind when a diagnosis of cat scratch disease is made.
Kamoi
Koju
K
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan. koju.oph@tmd.ac.jp
Yoshida
Tomoko
T
Takase
Hiroshi
H
Yokota
Mako
M
Kawaguchi
Tatsushi
T
Mochizuki
Manabu
M
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D018416:Bartonella henselae / Q000276:immunology*; D002372:Cat-Scratch Disease / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D014041:Tokyo / Q000453:epidemiology; D014605:Uveitis / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D055815:Young Adult
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M