Adenovirus DNA positivity in nasopharyngeal aspirate preceding hematopoietic stem cell transplantation: a very strong risk factor for adenovirus DNAemia in pediatric patients.
Human adenovirus (HAdV)-positive nasopharyngeal aspirate preceding hematopoietic stem cell transplantation was prospectively analyzed in 62 patients. By multivariate Cox proportional hazard models, HAdV-positive nasopharyngeal aspirate was the only predictor for HAdV DNAemia after hematopoietic stem cell transplantation (P < .001). HAdV DNAemia was a predictor for alloreactive disease. Early detection and intervention might help to prevent HAdV disease after hematopoietic stem cell transplantation.
de Pagter
Anne P J
AP
Department of Pediatric Immunology and Hematology, Wilhelmina Children's Hospital Utrecht, Utrecht, the Netherlands.
Haveman
Lianne M
LM
Schuurman
Rob
R
Schutten
Martin
M
Bierings
Marc
M
Boelens
Jaap-Jan
JJ
D000257:Adenoviridae Infections / Q000453:epidemiology* / Q000821:virology; D000260:Adenoviruses, Human / Q000302:isolation & purification*; D000293:Adolescent; D002353:Carrier State / Q000453:epidemiology* / Q000821:virology; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009305:Nasopharynx / Q000821:virology*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D014766:Viremia / Q000453:epidemiology* / Q000821:virology; D055815:Young Adult
D004279:DNA, Viral