Melohenines A and B, two unprecedented alkaloids from Melodinus henryi.
A phytochemical study on Melodinus henryi has led to the isolation of two novel alkaloids, melohenines A (1), a monoterpenoid indole alkaloid with additional skeletal carbons arranged compactly in eight rings, and melohenine B (2), an alkaloid with an unprecedented 6/9/6/6 tetracyclic ring system regarded as a key intermediate from indole to quinoline alkaloids. Their structures were elucidated by means of spectroscopic methods and further confirmed by X-ray diffraction analysis.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
Tao
T
Feng
Xiang-Hai
XH
Cai
Yan
Y
Li
Yuan-Yuan
YY
Wang
Ya-Ping
YP
Liu
Ming-Jin
MJ
Xie
Xiao-Dong
XD
Luo
D029062:Apocynaceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D046948:Secologanin Tryptamine Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D046948:Secologanin Tryptamine Alkaloids; C545602:melohenine A; C545603:melohenine B