International consensus report on the investigation and management of primary immune thrombocytopenia.
Previously published guidelines for the diagnosis and management of primary immune thrombocytopenia (ITP) require updating largely due to the introduction of new classes of therapeutic agents, and a greater understanding of the disease pathophysiology. However, treatment-related decisions still remain principally dependent on clinical expertise or patient preference rather than high-quality clinical trial evidence. This consensus document aims to report on new data and provide consensus-based recommendations relating to diagnosis and treatment of ITP in adults, in children, and during pregnancy. The inclusion of summary tables within this document, supported by information tables in the online appendices, is intended to aid in clinical decision making.
Department of Haematology, Barts and The London School of Medicine and Dentistry, London, United Kingdom. a.b.provan@qmul.ac.uk
Drew
D
Provan
Roberto
R
Stasi
Adrian C
AC
Newland
Victor S
VS
Blanchette
Paula
P
Bolton-Maggs
James B
JB
Bussel
Beng H
BH
Chong
Douglas B
DB
Cines
Terry B
TB
Gernsheimer
Bertrand
B
Godeau
John
J
Grainger
Ian
I
Greer
Beverley J
BJ
Hunt
Paul A
PA
Imbach
Gordon
G
Lyons
Robert
R
McMillan
Francesco
F
Rodeghiero
Miguel A
MA
Sanz
Michael
M
Tarantino
Shirley
S
Watson
Joan
J
Young
David J
DJ
Kuter
D000328:Adult; D002648:Child; D002675:Child, Preschool; D032921:Consensus; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology