[Effects of lipopolysaccharides of Bacterium prodigiosum on tumor growth and immunosuppression in mice].
OBJECTIVE
To observe the effects of lipopolysaccharides of Bacterium prodigiosum (BP-LPS) in inhibiting tumor growth and improving immunosuppression in mice.


METHODS
In mice bearing S180 tumor and a mouse model of immunosuppression induced by cyclophosphamide (CTX), the tumor growth, indexes of the immune organs and peripheral white blood cell count were measured after intraperitoneal injection of BP-LPS.


RESULTS
Injections of BP-LPS (40 U/kg) for 8 consecutive days resulted in a significant inhibition of the tumor growth in mice bearing S180 tumor (P<0.01), with a dose-dependent increase of the spleen indexes but no obvious changes in the thymus indexes. Intraperitoneal injections of BP-LPS for 7 days inhibited the reduction of peripheral white blood cells and spleen indexes in immunosuppressive mice, but did not produce any significant changes in normal mice.


CONCLUSIONS
BP-LPS can inhibit the tumor growth in tumor-bearing mice and enhance the immune functions of immunosuppressive mice.
Drug Research Institute, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. ycl138@sina.com
Chuan-lin
CL
Yu
Zheng-guang
ZG
Zhu
Lin-sheng
LS
Lei
Hua-lei
HL
Chang
Hui-ling
HL
Gao
Na-na
NN
Chen
Xian-guo
XG
Yang
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D005260:Female; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000302:isolation & purification / Q000494:pharmacology*; D011897:Random Allocation; D012705:Serratia / Q000737:chemistry*
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial