Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review.
Clear cell sarcoma of the kidney (CCSK) is uncommon pediatric renal tumor and can present a significant therapeutic challenge in those patients whose tumors spread beyond the kidney. Thus, identifying potential novel targets for treatment may be clinically important. Clear cell sarcoma of the kidney is characterized by a unique vascular pattern, in which nests of tumor cells are separated by regularly-spaced, fine fibrovascular septa. This distinctive histopathology raises the possibility that understanding the factors which drive angiogenesis in CCSK tumors may suggest new therapeutic targets. Here, we describe a case of CCSK and present immunohistochemical studies of its vasculature.
Boo
Yoon-Jung
YJ
Division of Pediatric Surgery, Department of Surgery, Korea University College of Medicine, Seoul 136-705, Korea.
Fisher
Jason C
JC
Haley
Mary Jo
MJ
Cowles
Robert A
RA
Kandel
Jessica J
JJ
Yamashiro
Darrell J
DJ
D001808:Blood Vessels / Q000473:pathology*; D002675:Child, Preschool; D016228:Endothelial Growth Factors / Q000235:genetics*; D004730:Endothelium, Vascular / Q000473:pathology*; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry / Q000706:statistics & numerical data; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000098:blood supply / Q000235:genetics* / Q000473:pathology*; D008297:Male; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000473:pathology*; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics; D051880:Receptors, Notch / Q000235:genetics; D018227:Sarcoma, Clear Cell / Q000098:blood supply* / Q000235:genetics / Q000473:pathology*
D016228:Endothelial Growth Factors; D051880:Receptors, Notch; D019009:Proto-Oncogene Proteins c-kit