Multi-gram scale synthesis of FR180204.
A concise synthesis of the ERK inhibitor FR180204 has been developed. The synthesis consists of six operationally simple steps and can be utilized to make multi-gram quantities of FR180204.
National Institutes of Health Chemical Genomics Center, 9800 Medical Center Drive, Rockville, Maryland 20850, USA. patnaiks@mail.nih.gov
Samarjit
S
Patnaik
Harry C
HC
Dietz
Wei
W
Zheng
Christopher
C
Austin
Juan J
JJ
Marugan
D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
C505241:FR 180204; D011720:Pyrazoles; D011724:Pyridazines