COMPARATIVE STUDIES IN ROUS SARCOMA WITH VIRUS, TUMOR CELLS, AND CHICK EMBRYO CELLS TRANSFORMED IN VITRO BY VIRUS : I. PRODUCTION OF MUCOPOLYSACCHARIDES.
The chick embryo fibroblast infected by Rous sarcoma virus in vitro acquires the capacity to produce the acid mucopolysaccharides which are found in the tumors caused by this virus and which are also produced by tumor cells in vitro. The transformed cell acquires synthetic as well as morphologic, metabolic, and proliferative properties characteristic of Rous sarcoma tumor cells in vivo and in vitro and the transformed cell may be analogous to the tumor cell produced by virus infection in vivo.
Virus Department of the National Institute of Public Health, Oslo, Norway, and M. Herbert Eisenhart Tissue Culture Laboratory of the Department of Bacteriology, The University of Rochester School of Medicine and Dentistry, Rochester, New York.
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