Two new jaspamide derivatives from the marine sponge Jaspis splendens.
Two new jaspamide derivatives 2 and 3, together with the parent compound jaspamide (1) have been isolated from the marine sponge Jaspis splendens collected in Kalimantan (Indonesia). The structures of the new compounds were unambiguously elucidated based on 1D and 2D NMR spectral data, mass spectrometry and comparison with jaspamide (1). The new derivatives inhibited the growth of mouse lymphoma (L5178Y) cell line in vitro with IC(50) values of <0.1 microg/mL.
Ebada
Sherif S
SS
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Universitaetsstrasse 1, D-40225 Duesseldorf, Germany. sherif.Elsayed@uni-duesseldorf.de
Wray
Victor
V
de Voogd
Nicole J
NJ
Deng
Zhiwei
Z
Lin
Wenhan
W
Proksch
Peter
P
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D007214:Indonesia; D020128:Inhibitory Concentration 50; D008223:Lymphoma / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry; D051379:Mice; D011161:Porifera / Q000737:chemistry*
D000970:Antineoplastic Agents; D047630:Depsipeptides; C546718:jaspamide Q; C546719:jaspamide R; C057531:jasplakinolide