Progenitors in motion: mechanisms of mobilization of endothelial progenitor cells.
Endothelial progenitor cells are a population of bone marrow-derived mononuclear cells thought to engage in endothelial repair and hence are considered potential therapeutic agents in many pathological conditions. The mechanism of their exit from the bone marrow to the circulation and damaged tissues, termed mobilization, has not been fully elucidated. Despite this, several pharmacological interventions have been shown to influence mobilization of these specialized cells. Here we review the current understanding of their mobilization.
King's College London, London SE1 7EH, UK. lindsey.tilling@kcl.ac.uk
Lindsey
L
Tilling
Philip
P
Chowienczyk
Brian
B
Clapp
D001854:Bone Marrow Cells / Q000378:metabolism / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000473:pathology; D002465:Cell Movement / Q000502:physiology*; D016207:Cytokines / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D016209:Interleukin-8; D009569:Nitric Oxide; D013234:Stem Cells / Q000378:metabolism / Q000502:physiology*
D016207:Cytokines; D016209:Interleukin-8; D009569:Nitric Oxide