Evaluation of a drug with wax-like properties as a melt binder.
The study investigates ibuprofen with wax-like properties as a multifunctional agent (as an active component and as a melt binder). Binding efficiency was compared with granules prepared by wet granulation using polyvinylpyrollidone (PVP K-30) as a binder for micromeritic, physical and mechanical properties such as angle of repose, particle size distribution Carr's index, Hausner's ratio, crushing strength, percentage fines, Heckel plot study and tensile strength. To check the binder distribution during melt granulation, the content uniformity was determined. To check changes in the physical state of ibuprofen, XRPD, DSC and FTIR studies were carried out. The present study underlines the fact that ibuprofen may be adopted as a binder in ibuprofen formulations using the melt granulation technique.
Dhumal
Ravindra S
RS
Department of Pharmaceutics, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Erandwane, Pune-411038, Maharashtra, India.
Shimpi
Shamkant L
SL
Chauhan
Bhaskar
B
Mahadik
Kakasahib R
KR
Paradkar
Anant
A
D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D005079:Excipients; D007052:Ibuprofen / Q000737:chemistry*; D007202:Indicators and Reagents; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D010592:Pharmaceutic Aids; D010968:Plasticizers; D011109:Polymethacrylic Acids; D011205:Povidone; D011208:Powders; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets; D013718:Tensile Strength; D014885:Waxes / Q000737:chemistry*; D014961:X-Ray Diffraction
D005079:Excipients; D007202:Indicators and Reagents; D010592:Pharmaceutic Aids; D010968:Plasticizers; D011109:Polymethacrylic Acids; D011208:Powders; D013607:Tablets; D014885:Waxes; C038300:methylmethacrylate-methacrylic acid copolymer; D011205:Povidone; D007052:Ibuprofen