[Listeriosis, a rare but severe foodborne infection].
Listeria monocytogenes is a Gram-positive bacillus widespread in nature and responsible for human and animal infections. Listeriosis is a severe and rare infection transmitted orally and vertically, frequently in the context of an underlying immunosuppression. L. monocytogenes is able to cross several barriers: intestinal mucosa, placenta and blood-brain barrier. Listeriosis is associated with a range of clinical presentations: ranging from acute gastroenteritis, septicaemia, central nervous system and maternofetal infections. Diagnosis is based on the isolation of L. monocytogenes from blood and cerebrospinal fluid cultures. Treatment relies on the synergic combination amoxicillin and gentamicin, with a mortality rate up to 30% despite adequate therapy.
Université Paris-Descartes, service de maladies infectieuses et tropicales, centre d'infectiologie Necker-Pasteur, hôpital Necker-Enfants malades, Assistance publique-Hôpitaux de Paris, 75015 Paris, France. caroline.charlier@nck.aphp.fr
Caroline
C
Charlier-Woerther
Alexandre
A
Leclercq
Olivier
O
Lortholary
Marc
M
Lecuit
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005517:Foodborne Diseases / Q000382:microbiology*; D006801:Humans; D006920:Hygiene; D008088:Listeriosis / Q000175:diagnosis / Q000188:drug therapy / Q000635:transmission*
D000900:Anti-Bacterial Agents