Healing reaction to mammary prostheses covered by textured silicone and silicone foam in rats.
OBJECTIVE
To compare the capsular reaction to two different coverings of silicone prosthesis through the biophysical characteristic of adherence and microscopical aspects of the inflammatory reaction and collagen formation.


METHODS
Thirty two Wistar rats were used. In the dorsum of each animal a silicone elastomer with a smooth superficies and another coated with texturized silicone (Mentor) was implanted. Another one, with the same smooth superficies and other coated with silicone foam (Lifesil), making up in each side, of the dorsum, the texturized and silicone foam group respectively. The animals were split into four groups to be evaluated at 7, 14, 30 and 60 days. On the evaluation dates the implant adherence was verified witch a tensiometer and the values in kgf were obtained. The material was sent to histological analysis with hematoxilin-eosin and picrosirius colorations, to evaluate the inflammatory reaction and collagen synthesis, respectively. The obtained data were submitted to statistical treatment.


RESULTS
There was more adherence of the tissue to the silicone foam (P<0,001). The inflammatory reaction was more intense in the same group, but without statistical significance. The number of giant cells and granulomas were more frequent in the silicone foam group. There was statistical significance at the 60 days for granulomas (P<0,028) and for all subgroups about number of giant cells (P< 0,012 to P<0,036). The thickness of the capsule in the silicone foam group was bigger, with statistical significance at seven days (P<0,028) and 60 days (P<0,012). The collagen deposition showed no difference in statistical analysis.


CONCLUSIONS
The capsular reaction to the silicone foam showed stronger adherence, bigger thickness and had more number of granulomas and giant cells. No difference was observed in the intensity of inflammatory reaction in relation to type I and III collagen, when compared to the texturized cover.
Balderrama
Cynthia Maria S Rojas
CM
Principles of Surgery Postgraduate Program, Evangelical Medical School, Curitiba, PR, Brazil. ipem@evangelico.org.br
Ribas-Filho
Jurandir Marcondes
JM
Malafaia
Osvaldo
O
Czeczko
Nicolau Gregori
NG
Dietz
Uli Alexandre
UA
Sakamoto
Danielle Giacometti
DG
Bittencourt
Leandra Pauletto Muniz
LP
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D018427:Breast Implants; D003094:Collagen / Q000378:metabolism; D005549:Foreign-Body Reaction / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D020034:Silicone Gels / Q000737:chemistry*; D013997:Time Factors; D000267:Tissue Adhesions / Q000503:physiopathology; D014945:Wound Healing / Q000502:physiology*
D001672:Biocompatible Materials; D020034:Silicone Gels; D003094:Collagen