It takes two to tango to the melanosome.
The role of clathrin adaptor proteins in sorting cargo in the biosynthetic and recycling routes is an area of intense research. In this issue, Delevoye et al. (2009. J. Cell Biol. doi:10.1083/jcb.200907122) show that a close interaction between the clathrin adaptor AP-1 and a kinesin motor KIF13A is essential for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes and for organelle biogenesis.
Margaret M. Dyson Vision Research Institute, Weill Medical College, Cornell University, New York, NY 10065, USA.
Aparna
A
Lakkaraju
Jose Maria
JM
Carvajal-Gonzalez
Enrique
E
Rodriguez-Boulan
D033961:Adaptor Protein Complex 1 / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D016547:Kinesins / Q000235:genetics / Q000378:metabolism*; D020460:Melanosomes / Q000378:metabolism*
D033961:Adaptor Protein Complex 1; C417670:KIF13A protein, human; D016547:Kinesins