Antibacterial clerodane diterpenes from Goldenrod (Solidago virgaurea).
Nine clerodane diterpenes, solidagoic acids C-I (1-7), cleroda-3,13(14)-dien-16,15:18,19-diolide (8) and cleroda-3,13(14)-dien-15,16:18,19-diolide (9) were isolated and characterised from the ethanol-ethyl acetate (1:1) extract of Solidago virgaurea. The structures were determined by NMR spectroscopic analysis. Several displayed moderate antibacterial activity against Staphylococcus aureus.
Starks
Courtney M
CM
Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences Inc., 1912 Innerbelt Business Center Drive, St. Louis, MO 63114, USA. cstarks@sequoiasciences.com
Williams
Russell B
RB
Goering
Matt G
MG
O'Neil-Johnson
Mark
M
Norman
Vanessa L
VL
Hu
Jin-Feng
JF
Garo
Eliane
E
Hough
Grayson W
GW
Rice
Stephanie M
SM
Eldridge
Gary R
GR
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D036624:Solidago / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D010936:Plant Extracts