The gut feeling of Treg cells: IL-10 is the silver lining during colitis.
Regulatory T cells that express the transcription factor Foxp3 are pivotal in suppressing autoimmune responses. A report in this issue describes a key role for interleukin 10 produced by lamina propria macrophages in maintaining Foxp3 expression during inflammatory responses in the intestine.
Derya
D
Unutmaz
Bali
B
Pulendran
D000818:Animals; D003092:Colitis / Q000276:immunology*; D051858:Forkhead Transcription Factors / Q000276:immunology*; D016753:Interleukin-10 / Q000276:immunology*; D007422:Intestines / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D009092:Mucous Membrane / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D016753:Interleukin-10