Line-scanning reflectance confocal microscopy of human skin: comparison of full-pupil and divided-pupil configurations.
Line-scanning, with pupil engineering and the use of linear array detectors, may enable simple, small, and low-cost confocal microscopes for clinical imaging of human epithelial tissues. However, a fundamental understanding of line-scanning performance within the highly scattering and aberrating conditions of human tissue is necessary, to translate from benchtop instrumentation to clinical implementation. The results of a preliminary investigation for reflectance imaging in skin are reported.
Gareau
Daniel S
DS
Memorial Sloan-Kettering Cancer Center, Dermatology Service, 160 East 53rd Street, New York, New York 10022, USA. dan@dangareau.net
Abeytunge
Sanjee
S
Rajadhyaksha
Milind
M
D004817:Epidermis / Q000473:pathology*; D004867:Equipment Design; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D018613:Microscopy, Confocal / Q000295:instrumentation* / Q000379:methods*; D016011:Normal Distribution; D055095:Optics and Photonics; D009991:Oscillometry / Q000379:methods; D012815:Signal Processing, Computer-Assisted