Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
We performed a genome-wide association study (GWAS) of systemic lupus erythematosus (SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using Illumina Human610-Quad BeadChips and replicating 78 SNPs in two additional cohorts (3,152 cases and 7,050 controls). We identified nine new susceptibility loci (ETS1, IKZF1, RASGRP3, SLC15A4, TNIP1, 7q11.23, 10q11.22, 11q23.3 and 16p11.2; 1.77 x 10(-25) < or = P(combined) < or = 2.77 x 10(-8)) and confirmed seven previously reported loci (BLK, IRF5, STAT4, TNFAIP3, TNFSF4, 6q21 and 22q11.21; 5.17 x 10(-42) < or = P(combined) < or = 5.18 x 10(-12)). Comparison with previous GWAS findings highlighted the genetic heterogeneity of SLE susceptibility between Chinese Han and European populations. This study not only advances our understanding of the genetic basis of SLE but also highlights the value of performing GWAS in diverse ancestral populations.
Han
Jian-Wen
JW
Zheng
Hou-Feng
HF
Cui
Yong
Y
Sun
Liang-Dan
LD
Ye
Dong-Qing
DQ
Hu
Zhi
Z
Xu
Jin-Hua
JH
Cai
Zhi-Ming
ZM
Huang
Wei
W
Zhao
Guo-Ping
GP
Xie
Hong-Fu
HF
Fang
Hong
H
Lu
Qian-Jin
QJ
Xu
Jian-Hua
JH
Li
Xiang-Pei
XP
Pan
Yun-Feng
YF
Deng
Dan-Qi
DQ
Zeng
Fan-Qin
FQ
Ye
Zhi-Zhong
ZZ
Zhang
Xiao-Yan
XY
Wang
Qing-Wen
QW
Hao
Fei
F
Ma
Li
L
Zuo
Xian-Bo
XB
Zhou
Fu-Sheng
FS
Du
Wen-Hui
WH
Cheng
Yi-Lin
YL
Yang
Jian-Qiang
JQ
Shen
Song-Ke
SK
Li
Jian
J
Sheng
Yu-Jun
YJ
Zuo
Xiao-Xia
XX
Zhu
Wei-Fang
WF
Gao
Fei
F
Zhang
Pei-Lian
PL
Guo
Qing
Q
Li
Bo
B
Gao
Min
M
Xiao
Feng-Li
FL
Quan
Cheng
C
Zhang
Chi
C
Zhang
Zheng
Z
Zhu
Kun-Ju
KJ
Li
Yang
Y
Hu
Da-Yan
DY
Lu
Wen-Sheng
WS
Huang
Jian-Lin
JL
Liu
Sheng-Xiu
SX
Li
Hui
H
Ren
Yun-Qing
YQ
Wang
Zai-Xing
ZX
Yang
Chun-Jun
CJ
Wang
Pei-Guang
PG
Zhou
Wen-Ming
WM
Lv
Yong-Mei
YM
Zhang
An-Ping
AP
Zhang
Sheng-Quan
SQ
Lin
Da
D
Li
Yi
Y
Low
Hui Qi
HQ
Shen
Min
M
Zhai
Zhi-Fang
ZF
Wang
Ying
Y
Zhang
Feng-Yu
FY
Yang
Sen
S
Liu
Jian-Jun
JJ
Zhang
Xue-Jun
XJ
D044466:Asian People / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male