[When an antidepressant helps too much].
Initiation of an antidepressant may result in hypomania or mania. The risk is lower with selective serotonin reuptake inhibitors and bupropione than with venlafaxine and tricyclic antidepressants. With a mood-stabilizing medication, the risk of hypomania or mania will remain very low, along with its correspondingly lower efficacy. The therapy involves discontinuation of the antidepressant, initiation or dose elevation of a maintenance drug preventing hypomania and mania, and when needed, short-course use of a second generation antipsychotic.
Turun yliopisto ja Satakunnan Psykiatripalvelu Oy, Rauman Erikoislääkärikeskus Valtakatu 9-11, Rauma.
Marko
M
Sorvaniemi
D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000139:chemically induced; D003866:Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D012307:Risk Factors
D000928:Antidepressive Agents