Prospective study on combination of electrical impedance scanning and ultrasound in estimating risk of development of breast cancer in young women.
Based on cost-effective ratio, there has not yet been imaging methods suitable for breast cancer screening in young women. The aim of this study was to evaluate the sensitivity and specificity of the combination of electrical impedance scanning (EIS) and ultrasound in identifying breast cancer for young women, to calculate relative risks, and to determine whether there has been some more accurate imaging method used in early detection of breast cancer in young women. A prospective and multicenter clinical study was conducted in young women aged 45 years and under. The young women (583 cases) scheduled for mammary biopsy underwent EIS and ultrasound, respectively. EIS and ultrasound results were compared with final histopathology results. Study end points included sensitivities and specificities of EIS, ultrasound and the combination method, as well as relative probability of breast cancer of positive patients detected by the combination of EIS and ultrasound. Of the 583 cases, 143 were diagnosed with breast cancer. The sensitivities of EIS, ultrasound and the combination method were 86.7% (124/143), 72% (103/143), and 93.7% (134/143); the specificities were 72.9% (321/440), 82.5% (363/440), and 64.1% (282/440), and the relative possibilities of breast cancer for the positive young women detected by EIS, ultrasound, and the combination method were 8.67, 5.77, and 14.84, respectively. The combination of EIS and ultrasound is likely to become an applicable method for early detection of breast cancer in young women.
Third Department of General Surgery, Xijing Hospital, Xi'an, China.
Ting
T
Wang
Kan
K
Wang
Qing
Q
Yao
Jiang-hao
JH
Chen
Rui
R
Ling
Ju-liang
JL
Zhang
Xiu-zhen
XZ
Dong
Feng
F
Fu
Ke-feng
KF
Dou
Ling
L
Wang
D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D055088:Early Detection of Cancer; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D012306:Risk; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary