Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide.
Fyfe
Paul K
PK
Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Rao
Vincenzo A
VA
Zemla
Aleksandra
A
Cameron
Scott
S
Hunter
William N
WN
D040981:Acinetobacter baumannii / Q000201:enzymology*; D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology; D020134:Catalytic Domain; D004789:Enzyme Activation / Q000187:drug effects; D008958:Models, Molecular; D009535:Nicotinamidase / Q000737:chemistry* / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011718:Pyrazinamide / Q000737:chemistry* / Q000494:pharmacology; D013379:Substrate Specificity
D000995:Antitubercular Agents; D011718:Pyrazinamide; D009535:Nicotinamidase