Helicobacter pylori infection and gastropathy: a comparison between Indonesian and Japanese patients.
OBJECTIVE
To compare the effects of Helicobacter pylori (H. pylori) infection on gastropathy between Indonesian and Japanese patients.


METHODS
Biopsy specimens were obtained during upper gastrointestinal endoscopy from 167 subjects (125 Indonesians and 42 Japanese) with uninvestigated symptoms of dyspepsia. The specimens were analyzed for the presence of H. pylori using urease analysis, histopathology, and cell culture. The grade and activity of gastritis was assessed using the updated Sydney system.


RESULTS
The percentages of Indonesian and Japanese patients who were H. pylori-positive at the antrum or body of the stomach were similar (68% and 59.5%, respectively; P = 0.316). Of those who were H. pylori-positive, more Japanese patients than Indonesian patients had high levels of polymorphonuclear cells (P = 0.001), mononuclear cells (P = 0.013), glandular atrophy (P = 0.000), and intestinal metaplasia (P = 0.011) in both the antrum and body of the stomach.


CONCLUSIONS
The grade of gastritis and prevalence of mucosal atrophy and intestinal metaplasia were higher in Japanese patients. The difference between Indonesian and Japanese patients was significant.
Abdullah
Murdani
M
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Cipto Mangunkusumo Hospital, Jalan Diponegoro No. 71, Jakarta 10430, Indonesia. murdani@cbn.net.id
Ohtsuka
Hiroyuki
H
Rani
Abdul Aziz
AA
Sato
Tadashi
T
Syam
Ari F
AF
Fujino
Masayuki A
MA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000706:statistics & numerical data*; D001284:Atrophy; D001706:Biopsy; D002478:Cells, Cultured; D018450:Disease Progression; D004415:Dyspepsia / Q000208:ethnology / Q000382:microbiology; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005757:Gastritis, Atrophic / Q000208:ethnology* / Q000382:microbiology / Q000473:pathology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000208:ethnology* / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000201:enzymology / Q000472:pathogenicity*; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D011230:Precancerous Conditions / Q000208:ethnology* / Q000382:microbiology / Q000473:pathology; D015995:Prevalence; D012720:Severity of Illness Index; D013274:Stomach Neoplasms / Q000208:ethnology* / Q000382:microbiology / Q000473:pathology; D014510:Urease / Q000032:analysis; D055815:Young Adult
D014510:Urease