Assessment of oxidative stress in coronary artery bypass surgery: comparison between the global index OXY-SCORE and individual biomarkers.
The performances of the OXY-SCORE, a summary index of oxidative stress, and of its individual components (plasma malondialdehyde (MDA), oxidized and reduced glutathione, individual antioxidant capacity, alpha- and gamma-tocopherol and urinary isoprostanes) were assessed in 47 patients undergoing coronary surgery, randomly assigned to cardiopulmonary bypass (CPB) or off-pump procedure (OPCAB) associated with less oxidative stress. The ability of the OXY-SCORE to classify correctly the patients was high (area under the ROC curve 0.90). Only free MDA showed a similar performance, but it was insensitive to the minor variations of the oxidative balance in the OPCAB group.
Centro Cardiologico Monzino IRCCS, Milan, Italy. fabrizio.veglia@ccfm.it
Fabrizio
F
Veglia
José P
JP
Werba
Elena
E
Tremoli
Isabella
I
Squellerio
Erminio
E
Sisillo
Alessandro
A
Parolari
Fabiana
F
Minardi
Viviana
V
Cavalca
D000368:Aged; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000032:analysis* / Q000097:blood / Q000652:urine; D001026:Coronary Artery Bypass; D047549:Coronary Artery Bypass, Off-Pump; D005260:Female; D005978:Glutathione / Q000097:blood; D019803:Glutathione Disulfide / Q000097:blood; D006801:Humans; D028421:Isoprostanes / Q000652:urine; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods / Q000706:statistics & numerical data; D018384:Oxidative Stress; D015203:Reproducibility of Results; D013997:Time Factors; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D015415:Biomarkers; D028421:Isoprostanes; D014810:Vitamin E; D008315:Malondialdehyde; D005978:Glutathione; D019803:Glutathione Disulfide