One-pot green synthesis of biocompatible arginine-stabilized magnetic nanoparticles.
A green one-step approach has been developed for the synthesis of amino-functionalized magnetite nanoparticles. The synthesis was accomplished by simply mixing FeCl2 with arginine under ambient conditions. It was found that the Fe2+/arginine molar ratio, reaction duration and temperature greatly influence the size, morphology and composition of magnetic nanoparticles. The arginine-stabilized magnetic nanoparticles were characterized by transmission electron microscopy, x-ray diffraction, x-ray photoelectron spectroscopy, thermogravimetric analysis, and Fourier transform infrared spectroscopy techniques. The results show that the prepared nanoparticles are spherically shaped with a nearly uniform size distribution and pure magnetite phase. The presence of arginine on the magnetic nanoparticle surface has been confirmed and the amount of surface arginine varies with the Fe2+/arginine molar ratio. The surface amine densities are calculated to be 5.60 and 7.84 micromol mg(-1) for magnetic nanoparticles prepared at 1:1 and 1:2 Fe2+/arginine molar ratio, respectively. The as-synthesized nanoparticles show superparamagnetic behavior at room temperature and good solubility in water. In addition, using a similar synthesis procedure, we have been able to synthesize superparamagnetic manganese and cobalt ferrite nanoparticles.
Wang
Zhongjun
Z
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, People's Republic of China.
Zhu
Hui
H
Wang
Xiaolei
X
Yang
Fan
F
Yang
Xiurong
X
D000588:Amines / Q000737:chemistry; D001120:Arginine / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D003035:Cobalt / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry; D055772:Green Chemistry Technology / Q000379:methods*; D006367:HeLa Cells; D006801:Humans; D008280:Magnetics; D008345:Manganese / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D000588:Amines; D001672:Biocompatible Materials; D005290:Ferric Compounds; C001215:ferrite; D003035:Cobalt; D008345:Manganese; D001120:Arginine