Does haloperidol have side effects on histological and stereological structure of the rat kidneys?
Haloperidol, a typical antipsychotic, is the most commonly prescribed medication for the treatment of mental health problems such as agitation and psychosis. We attempted to determine the effects of haloperidol treatment on the kidneys of female rats. In addition, we aimed to estimate the numerical density, total number, and height of renal glomeruli and the volume and volumetric fractions of the cortex, medulla, and whole kidneys, and tried to determine whether there was a change in these stereological parameters depending on haloperidol treatment. Both the qualitative and quantitative histological features of the kidney samples were analyzed with conventional histopathological and modern stereological methods at the light microscopic level. The total number of glomeruli and numerical density of glomerulus in the haloperidol-treated groups was not changed by increasing the dose in comparison to the control group. The mean height of the glomerulus significantly increased, especially in low-dose groups. In the haloperidol-treated groups, the volumetric fractions of the cortex to the whole kidney of the rats were significantly decreased by increasing the dose. The volumetric fractions of the medulla to the whole kidney of the rats were increased significantly in parallel by the given dose. In addition, we present quantitative findings showing that haloperidol is associated with many alterations in rat kidneys. It was shown that haloperidol may lead to undesirable changes in the kidney after chronic treatment with especially high doses.
Ataturk University, School of Medicine, Departments of Internal Medicine Division of Nephrology, Erzurum, Turkey.
Abdullah
A
Uyanik
Deniz
D
Unal
Zekai
Z
Halici
Ramazan
R
Cetinkaya
B Zuhal
BZ
Altunkaynak
Osman Nuri
ON
Keles
Beyzagul
B
Polat
Ahmet
A
Topal
Suat
S
Colak
Halis
H
Suleyman
Bunyami
B
Unal
D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006220:Haloperidol / Q000009:adverse effects* / Q000494:pharmacology; D007150:Immunohistochemistry; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects* / Q000473:pathology* / Q000648:ultrastructure; D007672:Kidney Cortex / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology*; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D007679:Kidney Medulla / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D008853:Microscopy / Q000379:methods; D009929:Organ Size; D011336:Probability; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values
D014150:Antipsychotic Agents; D006220:Haloperidol