Kidney transplantation in children with bladder augmentation or ileal conduit diversion.
BACKGROUND
Various congenital and acquired diseases of the lower urinary tract can lead to chronic renal failure requiring renal replacement therapy.


OBJECTIVE
The aim of the study was to assess problems and results of kidney transplantation in children with significant lower urinary tract dysfunction.


METHODS
Between 1984 and 2007, there were 33 kidney transplantations in children with end-stage renal disease and severe lower tract dysfunction out of 539 kidney transplantations performed in our department. The patients were 23 males and 10 females. Thirty patients received a kidney from a deceased donor, the remaining 3 from a living related donor. The age at transplantation ranged from 2.25 years to 19 years. In 26 patients an ileal conduit modo Bricker was created (in 21 patients at transplant operation). Bladder augmentation was performed in 6 patients and a continent urinary reservoir was created in 1.


RESULTS
Post-transplant follow-up ranged from 7 to 88 months (mean 32 months). Overall patient survival is 100% and graft survival is 97%. Creatinine concentrations ranged from 0.3 to 3.4 mg% (mean 0.92 mg%). Surgical complications were diagnosed in 16 patients. All surgical complications were treated successfully and none of them caused graft loss. Urinary tract infections (UTI) were the most commonly observed complication, occurring in 26/33 (78%) patients, but the majority of these UTI were asymptomatic and had no influence on graft function.


CONCLUSIONS
Kidney transplantation in children with lower urinary tract dysfunction and end-stage renal failure offers excellent medium term results in our experience, despite the creation of non-standard urinary drainage. Recurrent urinary tract infections are the most common complications in these patients, but in the majority of cases this does not lead to impairment of graft function.
Children's Memorial Health Institute, Department of Pediatric Surgery and Organ Transplantation, Al. Dzieci Polskich 20, Warsaw, Poland. dorbro1@poczta.onet.pl
D
D
Broniszczak
H
H
Ismail
P
P
Nachulewicz
M
M
Szymczak
T
T
Drewniak
M
M
Markiewicz-Kijewska
A
A
Kowalski
K
K
Jobs
E
E
Smirska
J
J
Rubik
L
L
Skobejko-Włodarska
P
P
Gastoł
A
A
Mikołajczyk
P
P
Kalicinski
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003559:Cystostomy; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D011044:Poland; D011183:Postoperative Complications; D012189:Retrospective Studies; D016896:Treatment Outcome; D014519:Ureterostomy; D001743:Urinary Bladder / Q000601:surgery*; D014547:Urinary Diversion / Q000009:adverse effects / Q000379:methods*; D016476:Urinary Reservoirs, Continent / Q000009:adverse effects; D014551:Urinary Tract / Q000002:abnormalities*; D014570:Urologic Diseases / Q000601:surgery*; D055815:Young Adult