Community-associated methicillin-resistant Staphylococcus aureus, Iowa, USA.
We performed antimicrobial drug susceptibility testing and molecular typing on invasive methicillin-resistant Staphylococcus aureus (MRSA) isolates (n = 1,666) submitted to the University of Iowa Hygienic Laboratory during 1999-2006 as part of a statewide surveillance system. All USA300 and USA400 isolates were resistant to <or=3 non-beta-lactam antimicrobial drug classes. The proportion of MRSA isolates from invasive infections that were either USA300 or USA400 increased significantly from 1999-2005 through 2006 (p<0.0001). During 2006, the incidence of invasive community-associated (CA)-MRSA infections was highest in the summer (p = 0.0004). Age <69 years was associated with an increased risk for invasive CA-MRSA infection (odds ratio [OR] 5.1, 95% confidence interval [CI] 2.06-12.64), and hospital exposure was associated with decreased risk (OR 0.07, 95% CI 0.01-0.51).
The University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Philip
P
Van De Griend
Loreen A
LA
Herwaldt
Bret
B
Alvis
Mary
M
DeMartino
Kristopher
K
Heilmann
Gary
G
Doern
Patricia
P
Winokur
Diana DeSalvo
DD
Vonstein
Daniel
D
Diekema
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007484:Iowa / Q000453:epidemiology; D008297:Male; D016106:Methicillin Resistance; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification*; D008875:Middle Aged; D012621:Seasons; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology*