Evolution of prognostic factors in hepatocellular carcinoma in Japan.
BACKGROUND
The surveillance of hepatocellular carcinoma (HCC) has become prevalent, and the modalities for its treatment have improved.


OBJECTIVE
To understand the changes that occur in the characteristics and prognostic factors of HCC with time.


METHODS
Newly diagnosed HCC patients were divided into two groups; patients treated before 31 December 2000 (n = 504), and after 1 January 2001 (n = 746), and their clinical backgrounds and prognostic factors were analysed.


RESULTS
The number of patients negative for both Hepatitis B surface antigen (HBsAg) and Hepatitis C virus antibody (HCVAb) increased with time (NBNC-HCC). The size of HCC decreased in patients who were positive for HBsAg (B-HCC) or HCVAb (C-HCC), whereas no difference was observed in NBNC-HCC. The patient survival of C-HCC improved; however, no difference was detected for NBNC-HCC. In multivariate analysis, low albumin, high aspartate aminotransferase (AST), ascites, large tumour size, multiple tumour number and high alpha-fetoprotein were risk factors for survival before 2000, whereas the presence of HBsAg was additionally selected as a good prognostic factor and AST was excluded after 2001.


CONCLUSIONS
The prognostic factors as well as clinical background of HCC changed with time, and the presence of HBsAg was found to be an additional good prognostic factor after 2001.
Nouso
K
K
Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan. nouso@cc.okayama-u.ac.jp
Kobayashi
Y
Y
Nakamura
S
S
Kobayashi
S
S
Toshimori
J
J
Kuwaki
K
K
Hagihara
H
H
Onishi
H
H
Miyake
Y
Y
Ikeda
F
F
Shiraha
H
H
Takaki
A
A
Iwasaki
Y
Y
Kobashi
H
H
Yamamoto
K
K
D000368:Aged; D014408:Biomarkers, Tumor / Q000276:immunology; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D004279:DNA, Viral / Q000276:immunology; D005260:Female; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors
D014408:Biomarkers, Tumor; D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies