The use of fibrin sealant as a glue for septoplasty and conchotomy.
The aim of our study was to investigate glue properties of a fibrin sealant in cases of septoplasty and conchotomy.



Double-blind prospective randomized study.



A study of 146 patients (80 M, 66 F) who underwent septoplasty and conchotomy was performed in Assaf Harofeh Medical Center Tzrifin, Israel. The patients were divided randomly into two groups: Group I (n = 74) underwent septoplasty with transseptal suturing, and conchotomy with glue as a haemostatic. Group II (n = 72) underwent septoplasty and conchotomy with glue as a haemostatic as well as septal cartilage and mucoperichodrial flaps sealant (no transseptal suturing). The glue was based on a concentrate of human clottable proteins and purified native human thrombin.



Our results showed complete healing in both groups without significant differences. One late postoperative nasal bleeding occurred in group I, and none in group II.



We conclude that the use of second-generation glue in endonasal surgery is well suited to stop nasal bleeding and seal intranasal flaps. Moreover, it might help to avoid transseptal suturing.
Vaiman
Michael
M
Department of Otolaryngology, Head and Neck Surgery, Assaf Harofeh Medical Center, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel. vaimed@yahoo.com
Sarfaty
Shlomo
S
Eviatar
Ephraim
E
D004311:Double-Blind Method; D005260:Female; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009300:Nasal Septum / Q000601:surgery*; D014420:Turbinates / Q000601:surgery*
D006490:Hemostatics