Therapeutic drug monitoring of lopinavir in human immunodeficiency virus-infected children receiving adult tablets.
Because of the lack of a lopinavir/ritonavir (LPV/r) pediatric formulation, 54 HIV-infected children were given generic LPV/r adult tablets. Of 54 children, 21 took cut pills to get the appropriate dose. The median (interquartile range) LPV trough serum concentration (C trough) was 6.7 (5.0-9.9) mg/L. All the children had C trough >1.0 mg/L and 96% had values >4.0 mg/L. LPV/r adult tablets can be used in children when it is necessary.
HIVNAT, Thai red cross AIDS Research center, Bangkok, Thailand.
Thanyawee
T
Puthanakit
Kulkanya
K
Chokephaibulkit
Piyarat
P
Suntarattiwong
Meena
M
Gorowara
Pimsiri
P
Leawsrisuk
Tulathip
T
Suwanlerk
Pitch
P
Boonrak
Kiat
K
Ruxrungtham
D000293:Adolescent; D002648:Child; D016903:Drug Monitoring; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D061466:Lopinavir; D011744:Pyrimidinones / Q000008:administration & dosage* / Q000627:therapeutic use*; D044967:Serum / Q000737:chemistry; D013607:Tablets / Q000008:administration & dosage*
D011744:Pyrimidinones; D013607:Tablets; D061466:Lopinavir