Serum concentration of vitamin D and parathyroid hormone after living kidney donation.
BACKGROUND
Metabolic consequences resulting from loss of renal mass in living kidney donors remain uncertain. There is recent focus on the changes in the active form of vitamin D because it is an agent for cancer regulation. The objective of the study was to measure serum concentrations of 1,25-dihydroxycholecalciferol, parathyroid hormone and insulin-like growth factor-1 (IGF-1) in living donors after kidney donation.


METHODS
Forty living kidney donors reported for follow-up visits. Their mean age was 46.14 years. They were women in 52.5% of cases. The mean observation period was 65.6 months. Serum 1,25(OH)2D3 and IGF-1 concentrations were measured by radioimmunoassay after extraction. Serum intact parathyroid hormone (PTH) was quantified using an enhanced chemiluminescence immunoassay system.


RESULTS
1,25-dihydroxycholecalciferol deficiency in 57.5% patients after nephrectomy was the most important change we noted. No correlation was observed between 1,25(OH)2D3 and PTH. A decreased serum IGF-1 concentration was observed in 17.5% of donors. However, decreases in both serum IGF-1 and 1,25(OH)2D3 concentrations were observed in 12.5% of donors.


CONCLUSIONS
Prospective studies may be essential to determine metabolic changes after nephrectomy among living kidney donors.
Department of General and Transplantation Surgery, Transplant Medicine and Internal Disease, Transplantation Institute, Medical University of Warsaw, Nowogrodzka 59 Street, 02-006 Warsaw, Poland. monicabien@o2.pl
M
M
Bieniasz
A
A
Kwiatkowski
P
P
Domagała
J
J
Gozdowska
R
R
Kieszek
K
K
Ostrowski
A
A
Deptuła
M
M
Durlik
L
L
Paczek
A
A
Chmura
D000328:Adult; D000368:Aged; D002117:Calcitriol / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007118:Immunoassay; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D010281:Parathyroid Hormone / Q000097:blood*; D013997:Time Factors; D014807:Vitamin D / Q000097:blood*; D055815:Young Adult
D010281:Parathyroid Hormone; D014807:Vitamin D; D007334:Insulin-Like Growth Factor I; D002117:Calcitriol