Strategies for non-responders.
When improvements in symptoms of hospital-acquired pneumonia are difficult to see, an investigation should be made into whether there truly is no response to antimicrobial treatment. Non-infectious disease that results in pneumonia-like shadows needs to be excluded. In pneumonia that is unresponsive to antimicrobials, differential diagnoses must be made with consideration of causative microorganism factors, host factors and medication factors, respectively. Preferably, the dose, administration frequency and administration time for the administered antimicrobials should be established based on PK/PD.
D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003428:Cross Infection / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006333:Heart Failure / Q000175:diagnosis; D006801:Humans; D007564:Japan; D008175:Lung Neoplasms / Q000175:diagnosis; D011014:Pneumonia / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D017410:Practice Guidelines as Topic; D017211:Treatment Failure
D000890:Anti-Infective Agents