Food-dependent exercise-induced anaphylaxis -importance of omega-5 gliadin and HMW-glutenin as causative antigens for wheat-dependent exercise-induced anaphylaxis-.
Food-dependent exercise-induced anaphylaxis (FDEIA) is a special form of food allergy where a food-intake alone does not induce any symptoms. However, allergic symptoms are elicited when triggering factors such as exercise or aspirin-intake are added after ingestion of the causative food. The most frequent causative foodstuff in Japan is wheat. The triggering factors, both exercise and aspirin-intake, facilitate allergen absorption from the gastrointestinal tract, resulting in allergic symptoms in the patients with wheat-dependent exercise-induced anaphylaxis (WDEIA). Analysis using purified wheat proteins revealed that approximately 80% of the patients with WDEIA have IgE reacting to omega-5 gliadin and the remaining of the patients to high molecular weight glutenin (HMW-glutenin). Simultaneous measurement of specific IgE to omega-5 gliadin and HMW-glutenin was found to be highly useful in diagnosing WDEIA compared with the routine diagnostic system for wheat.
Department of Dermatology, Shimane University Faculty of Medicine, Shimane, Japan. emorita@med.shimane-u.ac.jp
Eishin
E
Morita
Hiroaki
H
Matsuo
Yuko
Y
Chinuki
Hitoshi
H
Takahashi
Jörgen
J
Dahlström
Akira
A
Tanaka
D000485:Allergens / Q000276:immunology; D000707:Anaphylaxis / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D052179:Antigens, Plant / Q000276:immunology; D001250:Asthma, Exercise-Induced / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D005502:Food / Q000009:adverse effects; D041981:Gastrointestinal Tract / Q000378:metabolism; D005903:Gliadin / Q000276:immunology; D005983:Glutens / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism; D007159:Immunologic Tests; D021182:Wheat Hypersensitivity / Q000150:complications / Q000175:diagnosis / Q000276:immunology*
D000485:Allergens; D052179:Antigens, Plant; C475180:omega-5 gliadin, wheat; D007073:Immunoglobulin E; D005983:Glutens; D005903:Gliadin; C037302:glutenin