Amplitude of low-frequency oscillations in schizophrenia: a resting state fMRI study.
Recently, a great deal of interest has arisen in resting state fMRI as a measure of tonic brain function in clinical populations. Most studies have focused on the examination of temporal correlation between resting state fMRI low-frequency oscillations (LFOs). Studies on the amplitudes of these low-frequency oscillations are rarely reported. Here, we used amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF; the relative amplitude that resides in the low frequencies) to examine the amplitude of LFO in schizophrenia. Twenty-six healthy controls and 29 patients with schizophrenia or schizoaffective disorder participated. Our findings show that patients showed reduced low-frequency amplitude in proportion to the total frequency band investigated (i.e., fALFF) in the lingual gyrus, left cuneus, left insula/superior temporal gyrus, and right caudate and increased fALFF in the medial prefrontal cortex and the right parahippocampal gyrus. ALFF was reduced in patients in the lingual gyrus, cuneus, and precuneus and increased in the left parahippocampal gyrus. These results suggest LFO abnormalities in schizophrenia. The implication of these abnormalities for schizophrenic symptomatology is further discussed.
Hoptman
Matthew J
MJ
Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA. Hoptman@nki.rfmh.org
Zuo
Xi-Nian
XN
Butler
Pamela D
PD
Javitt
Daniel C
DC
D'Angelo
Debra
D
Mauro
Cristina J
CJ
Milham
Michael P
MP
D000328:Adult; D001683:Biological Clocks / Q000502:physiology*; D001921:Brain / Q000503:physiopathology*; D002421:Caudate Nucleus / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020534:Parahippocampal Gyrus / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000503:physiopathology; D012146:Rest; D012559:Schizophrenia / Q000503:physiopathology*; D013702:Temporal Lobe / Q000503:physiopathology