THE STABILITY OF THE ACID-BASE EQUILIBRIUM OF THE BLOOD IN NATURALLY NEPHROPATHIC ANIMALS AND THE EFFECT ON RENAL FUNCTION OF CHANGES IN THIS EQUILIBRIUM : II. A STUDY OF THE EFFICIENCY OF AN ALKALI TO PROTECT THE NATURALLY NEPHROPATHIC KIDNEY AGAINST THE TOXIC EFFECT OF AN ANESTHETIC.
1. A 0.9 per cent solution of sodium chloride when given intravenously to anesthetized naturally nephropathic animals is not effective in preventing the development of an acid intoxication and the associated kidney injury. 2. A solution of sodium carbonate equimolecular with a 0.9 per cent solution of sodium chloride when given intravenously to anesthetized naturally nephropathic animals confers a variable degree of protection to the kidney. 3. The degree of protection conferred by the alkaline solution is associated with the ability of the solution to maintain a normal acid-base equilibrium of the blood of the anesthetized animal.
Laboratory of Pharmacology of the University of North Carolina, Chapel Hill.
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Macnider