Chinese women's preferences for prenatal diagnostic procedure and their willingness to trade between procedures.
OBJECTIVE
To assess Chinese women's preference for the choice of a prenatal diagnosis test, karyotyping or rapid aneuploidy, and its relationship to maternal psychological state.


METHODS
Three hundred consenting women completed a self administered structured questionnaire which documented their psychological state and their preferred choice of diagnostic test for chromosomal abnormality using a discrete choice experiment design. Diagnostic tests were categorised according to three attributes: completeness of chromosomal information, procedure-to-result time interval and cost.


RESULTS
Participants indicated a preference towards the karyotype test irrespective of cost and procedure-to-result time interval. The value of obtaining the extra information provided by karyotyping above that of rapid aneuploidy was pound267.82 (95% CI 226.71-323.31). Women would only accept the rapid aneuploidy test if results where available 18 days sooner than if they were undergoing a karyotyping test. Among women who traded between diagnostic tests, the value of extra chromosomal information was reduced to pound153.83 (95% CI 125.81-192.19). Women with high trait anxiety scores (>40) did not preferentially select one test.


CONCLUSIONS
Chinese women showed a strong preference towards performing a full karyotype test and having a full chromosomal assessment performed for their pregnancy.
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Yiu Man
YM
Chan
Daljit Singh
DS
Sahota
Tak Yeung
TY
Leung
Kwong Wai
KW
Choy
Oi Ka
OK
Chan
Tze Kin
TK
Lau
D000328:Adult; D000782:Aneuploidy; D002681:China; D002755:Choice Behavior; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007621:Karyotyping; D057240:Patient Preference / Q000523:psychology*; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000523:psychology*