1,5-diazacyclohenicosane, a new cytotoxic metabolite from the marine sponge Mycale sp.
A new cyclic diamine, 1,5-diazacyclohenicosane (1), was isolated from samples of the marine sponge Mycale sp. collected at Lamu Island (Kenya). Its structure was determined by a combination of spectroscopic techniques, including (+)-HRESIMS and 1D and 2D NMR spectroscopy. The compound displayed cytotoxicity at the muM level against three human tumor cell lines.
Coello
Laura
L
Medicinal Chemistry Department, PharmaMar S.A.U., Pol. Ind. La Mina Norte, Avda de los Reyes 1, 28770-Colmenar Viejo (Madrid). Spain. lcoello@pharmamar.com
Martín
María Jesús
MJ
Reyes
Fernando
F
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006573:Heterocyclic Compounds, 1-Ring / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007630:Kenya; D011161:Porifera / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods
C546720:1,5-diazacyclohenicosane; D000970:Antineoplastic Agents; D006573:Heterocyclic Compounds, 1-Ring