Label-free aptamer-based sensor using abasic site-containing DNA and a nucleobase-specific fluorescent ligand.
A label-free adenosine sensor with emissive response is designed based on an AP site-containing aptamer/DNA duplex and a small fluorescent molecule 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND).
Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan.
Zhiai
Z
Xu
Kotaro
K
Morita
Yusuke
Y
Sato
Qing
Q
Dai
Seiichi
S
Nishizawa
Norio
N
Teramae
D000241:Adenosine / Q000737:chemistry*; D052157:Aptamers, Nucleotide / Q000737:chemistry*; D015374:Biosensing Techniques; D005456:Fluorescent Dyes / Q000737:chemistry*; D008024:Ligands; D009287:Naphthyridines / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*
C528376:2-amino-5,6,7-trimethyl-1,8-naphthyridine; D052157:Aptamers, Nucleotide; D005456:Fluorescent Dyes; D008024:Ligands; D009287:Naphthyridines; D009841:Oligonucleotides; D000241:Adenosine