[Current topics in stroke research].
This review summarizes current topics for brain protection against stroke. Although there has been no strategy for brain protection except for tissue plasminogen activator, recent advance in neuroscience has addressed subtypes of glutamate receptor on neuronal survival and death. Hypothermia and ischemic tolerance are the most reproducible strategies for brain protection in experimental ischemia, and they share metabolic down-regulation as a crucial factor for protective action. Development of collateral circulation (arteriogenesis), endogenous neurogenesis after ischemia, gene therapy and cell transplantation are all potential targets for developing a new strategy for stroke patients.
Kitagawa
Kazuo
K
Department of Neurology, Osaka University Graduate School of Medicine.
D001921:Brain / Q000378:metabolism; D017690:Cell Transplantation; D003097:Collateral Circulation / Q000502:physiology; D015536:Down-Regulation; D015316:Genetic Therapy; D006801:Humans; D007036:Hypothermia, Induced; D055495:Neurogenesis / Q000502:physiology; D018696:Neuroprotective Agents; D017470:Receptors, Glutamate; D020521:Stroke / Q000503:physiopathology / Q000628:therapy; D010959:Tissue Plasminogen Activator
D018696:Neuroprotective Agents; D017470:Receptors, Glutamate; D010959:Tissue Plasminogen Activator