Interhemispheric comparisons of cerebral blood flow velocity changes during mental tasks with transcranial Doppler sonography.
OBJECTIVE
The purpose of this study was to evaluate hemispheric asymmetry of cerebral blood flow changes during various mental tests by applying transcranial Doppler sonography (TCD) to simultaneously monitor bilateral cerebral blood flow velocity changes.


METHODS
Twenty-one participants without cerebrovascular disease performed 3 left hemispheric tasks (reading, calculation, and color scaling) and 3 right hemispheric tasks (face recognition, space imagination, and line orientation).


RESULTS
Mean velocities of the rest and performing periods did not differ significantly between the left and right hemispheric tasks. Although greater acceleration of blood flow velocity was observed on the left than on the right in most of the 6 tasks except line orientation (mean left - right ratio difference [D(l-r)] ranged from -0.018 to 0.071), this difference was larger for left hemispheric tasks (mean D(l-r) ranged from 0.050 to 0.071) than right hemispheric tasks (mean D(l-r) ranged from -0.018 to 0.034; P < .001). Further comparisons of each pair of (ie, left and right) hemispheric tasks revealed that the most suitable left and right hemispheric tasks to show hemispheric asymmetry were reading and line orientation, respectively (P < .001).


CONCLUSIONS
Hemispheric asymmetry of cerebral blood flow changes during mental tests is demonstrable with TCD only when comparing the D(l-r) in response to suitable paired left and right hemispheric tasks.
Lin
Tzu-Kang
TK
Division of Neurosurgery, Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University, Kweishan, Taiwan. tklin100@cgmh.org.tw
Ryu
Shan-Jin
SJ
Hsu
Peng-Wei
PW
D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology*; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D017585:Ultrasonography, Doppler, Transcranial; D055815:Young Adult