Proatherogenic disturbances in lipoprotein profile, associated enzymes and transfer proteins in women with iron deficiency anaemia.
OBJECTIVE
To characterize the lipid-related atherogenic risk factors in iron deficiency anaemia (IDA) patients.


METHODS
Twenty IDA women were compared to healthy age-matched controls. Lipoprotein profile, cholesteryl ester transfer protein (CETP), paraoxonase (PON) 1 and lipoprotein-associated phospholipase A(2) (LpPLA(2)) activities and plasma levels of oxidized-LDL were evaluated.


RESULTS
Triglycerides were higher (median [range]) (1.0 [0.5-1.9] vs. 0.7 [0.5-1.5] mmol/L, p<0.05) and HDL-C lower (mean + or - SD) (1.3 + or - 0.3 vs. 1.6 + or - 0.4 mmol/L, p<0.01) in the patients group. CETP (197 + or - 29% vs. 151 + or - 29% mL(-1) h(-1), p<0.001), PON 1 (122 + or - 17 vs. 140 + or - 33 micromol mL(-1) min(-1), p<0.05) and LpPLA(2) (9.6 + or - 2.0 vs. 8.1 + or - 1.7 micromol mL(-1) h(-1), p<0.05) activities were different in IDA women. No difference was observed in oxidized-LDL. Haemoglobin correlated negatively with triglycerides (r=-0.35, p<0.05), CETP (r=-0.62, p<0.001) and LpPLA(2) (r=-0.34, p<0.05), while ferritin was positively associated with HDL-C (r=0.39, p<0.05) and inversely with CETP (r=-0.49, p<0.005).


CONCLUSIONS
The alterations in lipoprotein profile, CETP, PON 1 and LpPLA(2) activities described in the present study indicate that non-treated IDA might represent a proatherogenic state.
Laboratory of Lipids and Lipoproteins, Department of Clinical Biochemistry, INFIBIOC, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, CONICET, Junín 956 (1113), Buenos Aires, Argentina.
Tomás
T
Meroño
Patricia
P
Sorroche
Leonardo A
LA
Gómez Rosso
Liliana
L
Casañas
Laura E
LE
Boero
Jorge A
JA
Arbelbide
Fernando D
FD
Brites
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000378:metabolism*; D018798:Anemia, Iron-Deficiency / Q000097:blood* / Q000150:complications* / Q000201:enzymology; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D050197:Atherosclerosis / Q000097:blood / Q000150:complications* / Q000201:enzymology; D016022:Case-Control Studies; D053480:Cholesterol Ester Transfer Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008875:Middle Aged
C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008074:Lipoproteins; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D043303:Aryldialkylphosphatase