Saoussanabiloïde, a novel antifungal alkaloid from Echiochilon fruticosum Desf. growing in Tunisia.
Bioactivity guided fractionation of Echiochilon fruticosum Desf. (Boraginaceae) butanolic extract biautography assay against fungi led to the isolation of a new bioactive alkaloid, named saoussanabiloïde (1). Its structure was established on the basis of spectroscopic measurements, IR, MS and 2D NMR using COSY, HMQC and HMBC experiments. The strongest inhibitory effect of the butanolic extract, from fractions derived from the crude extract and saoussanabiloïde (1), were observed against Fusarium oxysporum f. sp. niveum.
Laboratoire de Chimie des Substances Naturelles et de Sycnthèse Organique, Monastir, Tunisie.
S
S
Hammami
N
N
Mighri
H
H
Ben Jannet
N
N
Boughalleb
A
A
Zardi-Bergaoui
A
A
Nefzi
P
P
Abreu
Z
Z
Mighri
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D028082:Boraginaceae / Q000737:chemistry*; D005670:Fusarium / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014416:Tunisia
D000470:Alkaloids; D000935:Antifungal Agents; D010936:Plant Extracts