[Progress in regulation of activity and stability of ubiquitin protein ligase MDM2].
The ubiquitin protein ligase (E3) MDM2 (Murine double minute 2) possesses oncogenic activities. Overexpression of this protein enhances degradation and inactivation of the tumor suppressor p53. At least 7% of all human tumors exhibit inappropriate amplification of mdm2, whereas p53 gene remains in its wild-type configuration. This indicates that MDM2 may function in the p53-independent manner to promote tumorigenesis. Considering the critical role of MDM2, this review summarizes the current mechanisms and progress on MDM2 regulation in levels of gene control, mRNA transcription, post-translational modification, and interaction proteins.
Nie
Jing
J
Department of Biological Sciences and Technology, Tsinghua University, Beijing 100084, China. nnjj2002@163.com
Tian
Chun-Yan
CY
D000818:Animals; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D055550:Protein Stability; D051736:Proto-Oncogene Proteins c-mdm2 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
D051736:Proto-Oncogene Proteins c-mdm2