Separation of conformational isomers of bouvardin by high-pressure liquid chromatography.
Bouvardin, a bicyclic hexapeptide, was found to exhibit a solvent-dependent conformational distribution. HPLC was utilized to separate the two different conformers whose distribution ratio was dependent on the solvent of injection.
College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, USA.
J J
JJ
Hoffmann
S J
SJ
Torrance
J R
JR
Cole
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D010456:Peptides, Cyclic / Q000302:isolation & purification*; D011487:Protein Conformation; D013237:Stereoisomerism
D010456:Peptides, Cyclic; C018234:bouvardin