Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
We performed a genome-wide association study (GWAS) of systemic lupus erythematosus (SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using Illumina Human610-Quad BeadChips and replicating 78 SNPs in two additional cohorts (3,152 cases and 7,050 controls). We identified nine new susceptibility loci (ETS1, IKZF1, RASGRP3, SLC15A4, TNIP1, 7q11.23, 10q11.22, 11q23.3 and 16p11.2; 1.77 x 10(-25) < or = P(combined) < or = 2.77 x 10(-8)) and confirmed seven previously reported loci (BLK, IRF5, STAT4, TNFAIP3, TNFSF4, 6q21 and 22q11.21; 5.17 x 10(-42) < or = P(combined) < or = 5.18 x 10(-12)). Comparison with previous GWAS findings highlighted the genetic heterogeneity of SLE susceptibility between Chinese Han and European populations. This study not only advances our understanding of the genetic basis of SLE but also highlights the value of performing GWAS in diverse ancestral populations.
Jian-Wen
JW
Han
Hou-Feng
HF
Zheng
Yong
Y
Cui
Liang-Dan
LD
Sun
Dong-Qing
DQ
Ye
Zhi
Z
Hu
Jin-Hua
JH
Xu
Zhi-Ming
ZM
Cai
Wei
W
Huang
Guo-Ping
GP
Zhao
Hong-Fu
HF
Xie
Hong
H
Fang
Qian-Jin
QJ
Lu
Jian-Hua
JH
Xu
Xiang-Pei
XP
Li
Yun-Feng
YF
Pan
Dan-Qi
DQ
Deng
Fan-Qin
FQ
Zeng
Zhi-Zhong
ZZ
Ye
Xiao-Yan
XY
Zhang
Qing-Wen
QW
Wang
Fei
F
Hao
Li
L
Ma
Xian-Bo
XB
Zuo
Fu-Sheng
FS
Zhou
Wen-Hui
WH
Du
Yi-Lin
YL
Cheng
Jian-Qiang
JQ
Yang
Song-Ke
SK
Shen
Jian
J
Li
Yu-Jun
YJ
Sheng
Xiao-Xia
XX
Zuo
Wei-Fang
WF
Zhu
Fei
F
Gao
Pei-Lian
PL
Zhang
Qing
Q
Guo
Bo
B
Li
Min
M
Gao
Feng-Li
FL
Xiao
Cheng
C
Quan
Chi
C
Zhang
Zheng
Z
Zhang
Kun-Ju
KJ
Zhu
Yang
Y
Li
Da-Yan
DY
Hu
Wen-Sheng
WS
Lu
Jian-Lin
JL
Huang
Sheng-Xiu
SX
Liu
Hui
H
Li
Yun-Qing
YQ
Ren
Zai-Xing
ZX
Wang
Chun-Jun
CJ
Yang
Pei-Guang
PG
Wang
Wen-Ming
WM
Zhou
Yong-Mei
YM
Lv
An-Ping
AP
Zhang
Sheng-Quan
SQ
Zhang
Da
D
Lin
Yi
Y
Li
Hui Qi
HQ
Low
Min
M
Shen
Zhi-Fang
ZF
Zhai
Ying
Y
Wang
Feng-Yu
FY
Zhang
Sen
S
Yang
Jian-Jun
JJ
Liu
Xue-Jun
XJ
Zhang
D044466:Asian People / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male