The role of neutrophils in the event of intestinal inflammation.
The transmigration of polymorphonuclear leukocytes (PMNs; neutrophils) into the intestinal lumen is a classical phenomenon associated with a wide variety of disease states, including those of both pathogenic and autoimmune/idiopathic origin. While PMNs are highly effective at killing invading pathogens by releasing microbiocidal products, excessive or unnecessary release of these substances can cause substantial damage to the intestinal epithelium. Therefore, it is necessary to understand the underlying mechanisms that lure neutrophils into the lumen allowing them to perform their desired functions, so that researchers may begin to identify which processes may be potential targets for inhibiting the transmigration of PMNs during noninfectious states.
The Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA, USA.
Karen L
KL
Mumy
Beth A
BA
McCormick
D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D000818:Animals; D016503:Drug Delivery Systems; D004760:Enterocolitis / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology; D007239:Infections / Q000276:immunology; D007413:Intestinal Mucosa / Q000276:immunology* / Q000378:metabolism; D008954:Models, Biological; D020556:Neutrophil Infiltration / Q000187:drug effects / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
C038243:8-hydroxy-11,12-epoxyeicosa-5,9,14-trienoic acid; D015126:8,11,14-Eicosatrienoic Acid