Stereostructure and biological activity of 42-hydroxy-palytoxin: a new palytoxin analogue from Hawaiian Palythoa subspecies.
This paper reports on the analysis of the toxin content from Palythoa tuberculosa and Palythoa toxica samples collected off of the Hawaiian coast. Our work, based on in-depth high-resolution liquid chromatography-mass spectrometry analysis along with extensive NMR study, led us to structurally characterize 42-hydroxy-palytoxin, a new palytoxin congener. This toxin and palytoxin itself appeared to be the major components of toxic extract from a P. tuberculosa sample, while 42-hydroxy-palytoxin was proven by far to be the main palytoxin derivative in P. toxica. Functional studies on this new palytoxin-like compound suggest that the new palytoxin analogue and palytoxin itself present similar biological activities.
Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli "Federico II", via D. Montesano, 49, 80131 Napoli, Italy.
Patrizia
P
Ciminiello
Carmela
C
Dell'aversano
Emma
E
Dello Iacovo
Ernesto
E
Fattorusso
Martino
M
Forino
Laura
L
Grauso
Luciana
L
Tartaglione
Chiara
C
Florio
Paola
P
Lorenzon
Marco
M
De Bortoli
Aurelia
A
Tubaro
Mark
M
Poli
Gary
G
Bignami
D000178:Acrylamides / Q000737:chemistry*; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D003064:Cnidarian Venoms / Q000737:chemistry / Q000627:therapeutic use*; D006254:Hawaii; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011714:Pyrans / Q000737:chemistry / Q000627:therapeutic use*; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism; D000095702:Polyether Toxins
D000178:Acrylamides; D003064:Cnidarian Venoms; D011714:Pyrans; C547187:42-hydroxypalytoxin; D000095702:Polyether Toxins; C010272:palytoxin