[Human toxicokinetic of hexobarbital after acute multi-drug intoxication].
A 33-year-old man was hospitalized unconscious on suspicion of acute diazepam and hexobarbital intoxication, a barbiturate not marketed in France. Its quantification was developed by gas chromatography coupled with mass spectrometry detection and validated on one-hundred microL of plasma extracted by a liquid/liquid method. Hexobarbital and diazepam concentrations in initial plasma samples were at toxic levels, respectively 15 900 ng/mL and 13 800 ng/mL. Hexobarbital toxicokinetic was studied during 175 h and analysed with a non-compartmental model. Half-life value of 61,8 h was found, being much longer than already published hexobarbital half-lives (between 3.2 h and 6.9 h). The reasons of this long half-life were discussed according to metabolism and pharmacogenetic.
Laboratoire de Pharmacologie-Toxicologie, Centre Hospitalier Universitaire Raymond Poincaré, AP-HP, Garches, France.
Emmanuelle
E
Guillot
Emuri
E
Abe
Emilie
E
Gautier
Djillali
D
Annane
Jean-Claude
JC
Alvarez
D000328:Adult; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics / Q000378:metabolism; D065731:Cytochrome P-450 CYP2C19; D008401:Gas Chromatography-Mass Spectrometry; D006207:Half-Life; D006591:Hexobarbital / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning*; D008297:Male; D015203:Reproducibility of Results; D019966:Substance-Related Disorders / Q000150:complications*
D006993:Hypnotics and Sedatives; D006591:Hexobarbital; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19