Site-selective scission of human genome by artificial restriction DNA cutter.
By using an artificial restriction DNA cutter which is composed of Ce(iv)/EDTA and two pseudo-complementary peptide nucleic acid strands (pcPNAs), only one target site in the whole genome of human beings (one site in the X chromosome) was selectively hydrolyzed.
Ito
Kenichiro
K
Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, 153-8904 Tokyo, Japan.
Katada
Hitoshi
H
Shigi
Narumi
N
Komiyama
Makoto
M
D001483:Base Sequence; D041321:Chromosomes, Human, X; D004247:DNA / Q000235:genetics; D015894:Genome, Human; D006801:Humans
D004247:DNA