The influence of the recipient's body weight on the probability to obtain a heart transplant-POLKARD HF registry.
BACKGROUND
The aim of the study was to analyze the influence of body weight of the adult heart recipient on the chance to obtain a transplant.


METHODS
We analyzed the data from all 658 patients listed for heart transplantation.


RESULTS
During the follow-up period, 325 (49%) of listed patients underwent transplantation with 102 (15%) succumbing before heart transplantation. The mean weight of transplanted patients was 73.7 +/- 13.7 kg and 81.2 +/- 15.4 kg for those not transplanted (P < .00001). Patients were divided according to body weight in two groups: light = below 80 kg (n = 360) or heavy > or = 80 kg or above (n = 297). On the transplant list, 111 heavy patients (37%) versus 213 light patients (59%) underwent the procedure, a significant difference. The waiting time among light patients was 255 versus heavy patients of 395 days (P < .005). There was a similar number of deaths before transplantation among the light (n = 56 360 patients; 15.5%) versus the heavy group (49/297; 16%). Upon multivariate Cox mode analysis independent factors related to not receiving a heart transplant were greater weight, systolic blood pressure, pulmonary vascular resistance, Heart Failure Survival Score (HFSS) score and lower N-terminal pro-brain natriuretic peptide (NTproBNP) levels.


CONCLUSIONS
Among adult heart transplant candidates, the chance to receive a heart transplant significantly decreased when the recipient's weight exceeded 80 kg. Patients with a body weight more than 110 kg had a poor chance to receive a heart transplantation.
Department of Heart Failure and Transplantation, Institute of Cardiology, 04-628 Warszawa, ul Alpejska, Poland. tzielin@ikard.pl
T
T
Zieliński
M
M
Sobieszczańska-Małek
A
A
Browarek
M
M
Piotrowska
M
M
Zakliczyński
P
P
Przybyłowski
K
K
Roguski
J
J
Sadowski
M
M
Zembala
J
J
Korewicki
D000328:Adult; D001794:Blood Pressure; D001827:Body Height; D001835:Body Weight; D003971:Diastole; D006333:Heart Failure / Q000401:mortality / Q000503:physiopathology* / Q000601:surgery; D006339:Heart Rate; D016027:Heart Transplantation / Q000401:mortality / Q000502:physiology / Q000706:statistics & numerical data*; D006801:Humans; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D050177:Overweight / Q000453:epidemiology; D010446:Peptide Fragments / Q000097:blood; D011044:Poland; D011336:Probability; D012042:Registries; D015996:Survival Rate; D017741:Survivors; D013851:Thinness / Q000453:epidemiology; D014655:Vascular Resistance; D016277:Ventricular Function, Left
D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain