[Fc receptor functions in host and immune regulation].
Specific receptors for antibody, named Fc Receptors are proteins found on the surface of leukocytes. Fc receptors contribute to the protective functions of the immune system, by binding to antibodies that are attached to infected cells or invading pathogens. Fc receptor activity stimulates phagocytic or cytotoxic cells to destroy microbes, or infected cells by antibody-mediated phagocytosis or antibody-dependent cell-mediated cytotoxicity. This review describes the main types of Fc receptors and the signal transduction pathways that are initiated by them in various leukocytes, with emphasis on activation of phagocytosis. New findings on the regulatory role of Fc receptors on immune function are also discussed.
Mora
Nancy
N
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México.
Rosales
Carlos
C
D007109:Immunity / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D010587:Phagocytosis / Q000276:immunology; D011961:Receptors, Fc / Q000276:immunology*
D011961:Receptors, Fc