Olefin metathesis in carotenoid synthesis.
Olefin metathesis is a powerful and widely applicable synthetic method for carbon-carbon double bond formation. However, its application to the synthesis of conjugating polyene chains has been very limited because of possible undesired side reactions. We attempted to apply this method to the synthesis of symmetrical carotenoids. In this paper, the syntheses of violaxanthin and mimulaxanthin are described using the olefin metathesis protocol.
Kajikawa
Takayuki
T
Department of Chemistry and Open Research Center on Organic Tool Molecules, School of Science and Technology, Kwansei Gakuin University, Gakuen 2-1, Sanda, Hyogo, 669-1337, Japan.
Iguchi
Naoko
N
Katsumura
Shigeo
S
D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D002338:Carotenoids / Q000138:chemical synthesis*; D002625:Chemistry, Organic / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D024341:Xanthophylls / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry
D000475:Alkenes; D024341:Xanthophylls; D002338:Carotenoids; C005613:violaxanthin