Haloperidol-induced neuroleptic malignant syndrome complicated by hyperosmolar hyperglycemic state.
Neuroleptic malignant syndrome (NMS) is a life-threatening neurologic emergency that may be caused by neuroleptic agents of any class. The association with hyperosmolar hyperglycemic state (HHS) is rare and carries a grave prognosis. We describe the case of a 25-year-old male patient with haloperidol-induced NMS complicated by HHS that culminated in the patient's death despite all treatment efforts. Physicians caring for diabetic psychiatric patients who are treated with neuroleptic agents should be aware of this association that may be prevented by tight glycemic control.
Department of Internal Medicine C, Ha'emeK Medical Center, Afula, Affiliated to the Technion-Israel Institute of Technology, Faculty of Medicine, Haifa, Israel.
Wasseem
W
Rock
Mazen
M
Elias
Ami
A
Lev
Walid R
WR
Saliba
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D017809:Fatal Outcome; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D008297:Male; D008305:Malignant Hyperthermia / Q000150:complications / Q000188:drug therapy; D009110:Munchausen Syndrome / Q000188:drug therapy; D009459:Neuroleptic Malignant Syndrome / Q000150:complications* / Q000209:etiology*; D012559:Schizophrenia / Q000188:drug therapy
D014150:Antipsychotic Agents; D006220:Haloperidol