Overt immediate hemolytic transfusion reaction attributable to anti-Wr(a).
Wr(a) is a low-prevalence antigen. Anti-Wr(a) is a relatively common antibody present in approximately 1 in 100 healthy blood donors. Anti-Wr(a) is reported to cause different degrees of hemolysis in transfusion and in HDN, ranging from benign to severe. This report describes an acute overt hemolytic transfusion reaction in a patient whose serum contained anti-Wr(a) and who received a Wr(a+) RBC component.
Geisinger Medical Center, Danville, PA 17822, USA.
F N
FN
Boctor
D000369:Aged, 80 and over; D000741:Anemia, Aplastic / Q000097:blood / Q000628:therapy; D001457:Anion Exchange Protein 1, Erythrocyte; D001789:Blood Group Antigens; D001787:Blood Group Incompatibility / Q000097:blood* / Q000209:etiology / Q000628:therapy; D017707:Erythrocyte Transfusion; D006461:Hemolysis; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D008232:Lymphoproliferative Disorders / Q000097:blood / Q000628:therapy; D008297:Male
D001457:Anion Exchange Protein 1, Erythrocyte; D001789:Blood Group Antigens; D007518:Isoantibodies; C454201:SLC4A1 protein, human