Development of antisynthetase syndrome in a patient with rheumatoid arthritis.
Rheumatoid arthritis (RA) and antisynthetase syndrome (ASS) are distinct clinical syndromes, and their co-occurrence is rarely encountered. The authors report the case of a 56-year-old female patient with RA of 3 years duration who suddenly developed ASS, and include a review of the literature. The patient was diagnosed with ASS based on; positivity for anti-histidyl-tRNA synthetase (Jo-1) antibody, interstitial lung disease, polyarthritis, and mechanic's hands. High-dose corticosteroid and pulse intravenous cyclophosphamide were used to control the ASS. This case demonstrates that ASS should be considered during clinical presentations due to its potential overlap with RA.
Department of Rheumatology, Chonnam National University Medical School and Hospital, 8 Hak-dong, Dong-ku, Gwangju 501-757, Republic of Korea.
Cheol-Kyu
CK
Park
Tae-Jong
TJ
Kim
Young-Nan
YN
Cho
Il-Soo
IS
Kim
Ho-Jun
HJ
Lee
Kyung-Eun
KE
Lee
Seong-Chang
SC
Park
Jong-Sun
JS
Kim
Dong-Jin
DJ
Park
Sung-Ji
SJ
Lee
Seong-Rye
SR
Seo
Jeong-Chul
JC
Kim
Sang-Gook
SG
Song
Shin-Seok
SS
Lee
Yong-Wook
YW
Park
D001172:Arthritis, Rheumatoid / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009220:Myositis / Q000188:drug therapy / Q000209:etiology