Induction chemotherapy with docetaxel, 5-FU and CDDP (DFP) for advanced gastric cancer.
BACKGROUND
The aim of this study was to evaluate the feasibility and efficacy of modified triplet chemotherapy with docetaxel, 5-fluorouracil and cisplatin as induction chemotherapy for advanced gastric cancer (AGC).


METHODS
Treatment-naïve patients with AGC were eligible. The regimen consisted of 350 mg/m(2)/day 5-FU by continuous infusion on days 1 to 5, 10 mg/m(2)/day CDDP intravenously on days 1 to 5, and docetaxel at 60 mg/m(2)/day intravenously on day 1. After 2 cycles (each cycle consisted of 4 weeks), surgical resection was attempted, 2-4 weeks after the completion of the regimen.


RESULTS
Eighteen patients were enrolled. Adverse events included grade 3 anorexia and nausea in 16.7% and 11.1% and grade 4 leukocytopenia and neutropenia in 5.6% and 27.8%, respectively. The overall response rate was 44.4%. Surgery was conducted in 15 patients. The 1- and 3-year survival rates were 75.6% and 51.1%, respectively.


CONCLUSIONS
The modified triplet combination therapy is effective and well tolerated by patients with AGC.
Division of Gastroenterological Surgery, Department of Surgery, Graduate School of Medicine, Osaka University, 2-2, E2, Yamadaoka, Suita, Osaka 565-0871, Japan.
Kazuyoshi
K
Yamamoto
Yoshiyuki
Y
Fujiwara
Toshiro
T
Nishida
Shuji
S
Takiguchi
Kiyokazu
K
Nakajima
Hiroshi
H
Miyata
Makoto
M
Yamasaki
Masaki
M
Mori
Yuichiro
Y
Doki
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000601:surgery; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D000077143:Docetaxel; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000601:surgery; D043823:Taxoids / Q000008:administration & dosage / Q000009:adverse effects
D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil