[Postoperative survival comparison of non-small cell lung cancer between disease with peripheral direct adjacent invasion and resectable T4 disease with mediastinal structures invasion].
OBJECTIVE
To determine the postoperative survival of non-small cell lung cancer with peripheral adjacent lobe invasion by comparing it with that of resectable T4 disease with mediastinal structures invasion, and hence try to find out some clue concerning how to define these patients for a reasonable T stage.


METHODS
A retrospective analysis was conducted to assess the survival of NSCLC patients with peripheral direct adjacent lobe invasion (group A, n = 28), and compared it with that of with mediastinal structures invasion (group B, n = 21). All patients underwent surgery between March, 1997 and October, 2006, and were pathologically confirmed with NOMO disease. Kaplan-Meier method was used to calculate the survival, and Log-Rank test was used to compare the postoperative survival between two groups.


RESULTS
The sex, age, pathology, and pulmonary function were well balanced between the two groups. There was one operative death from group A. The disease specific 2 year, 3year, 5 year survival in group A and group B was: 68.7%, 61.1%, 40.7%, and 64.7%, 58.2%, 43.7%, respectively. The median survival for group A and group B was 54 months and 49 moths, respectively, with no statistically significant difference (P = 0.931).


CONCLUSIONS
NSCLC with peripheral adjacent lobe invasion has a similar survival prognosis with that of resectable T4 disease with mediastinal structures invasion. Among carefully selected patients, long-term survival is anticipated for NSCLC with adjacent lobe invasion. However, further studies are needed to determine the optimal T stage for these patients.
Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangzhou 510060, China.
Hao-Xian
HX
Yang
Xue
X
Hou
Peng
P
Lin
Tie-Hua
TH
Rong
Hong
H
Yang
Jian-Hua
JH
Fu
D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009367:Neoplasm Staging; D011184:Postoperative Period; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome