CT enteroclysis features of uncomplicated celiac disease: retrospective analysis of 44 patients.
OBJECTIVE
To describe the computed tomographic (CT) enteroclysis features of uncomplicated celiac disease (CD) and to determine the most indicative appearance of this condition by using a retrospective case-control study.


METHODS
This study had institutional review board approval. The CT enteroclysis examinations of 44 consecutive patients with proved uncomplicated CD (21 men, 23 women; mean age, 44.45 years) were reviewed by two blinded readers and compared with those obtained in 44 control subjects (21 men, 23 women; mean age, 44.48 years), who were matched for sex and age. Comparisons were calculated by using univariate analysis.


RESULTS
Reversed jejunoileal fold pattern had the highest specificity (100%; 44 of 44; 95% confidence interval [CI]: 91.96%, 100%) and was the most discriminating independent variable for the diagnosis of uncomplicated CD (odds ratio, 39.9; P < .0001) but had a sensitivity of 63.64% (28 of 44; 95% CI: 47.77%, 77.59%). Ileal fold thickening, vascular engorgement, and splenic atrophy were other variables that strongly correlated with the presence of uncomplicated CD.


CONCLUSIONS
CT enteroclysis may help establish a diagnosis of uncomplicated CD and may clarify the cause of nonspecific gastrointestinal symptoms in patients with unknown CD. However, future prospective trials are needed to determine the actual value of CT enteroclysis in patients with CD and validate the clinical usefulness of CT enteroclysis in the detection of unknown uncomplicated CD.
Soyer
Philippe
P
Department of Abdominal Imaging, and Clinical Research Unit, Hôpital Lariboisière-AP-HP-GHU Nord and Diderot-Paris 7 University, 2 rue Ambroise Paré, 75475 Paris Cedex 10, France. philippe.soyer@lrb.aphp.fr
Boudiaf
Mourad
M
Dray
Xavier
X
Fargeaudou
Yann
Y
Vahedi
Kouroche
K
Aout
Mounir
M
Vicaut
Eric
E
Hamzi
Lounis
L
Rymer
Roland
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002446:Celiac Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007082:Ileum / Q000000981:diagnostic imaging*; D007583:Jejunum / Q000000981:diagnostic imaging*; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008297:Male; D008643:Mesentery; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013154:Spleen / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D055815:Young Adult