Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans.
In humans, the kinetics of the appearance of memory B cells and plasma cells during primary immunization are not well defined. In this study, we assessed the primary B-cell response of rabies-antigen naive volunteers during a 3-dose course of rabies vaccine compared with the B-cell response to a booster dose of rabies vaccine given to previously immunized volunteers. After a single dose of vaccine, in the naive group plasma and memory B cells appeared later (peak at day 10) than in the primed group (peak at day 7) and were at lower frequency. The most rapid responses (day 4) were detected after a third immunization in the naive group. This is the first study to document the detailed kinetics of the plasma cell and memory B-cell responses to immunization in adult humans and to demonstrate differences in the responses that relate to the preexisting immune status of the persons.
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Oxford, United Kingdom. Geraldine.BlanchardRohner@paediatrics.ox.ac.uk
Geraldine
G
Blanchard-Rohner
Anoop S
AS
Pulickal
Cornelia M
CM
Jol-van der Zijde
Matthew D
MD
Snape
Andrew J
AJ
Pollard
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D007156:Immunologic Memory / Q000276:immunology*; D008875:Middle Aged; D010950:Plasma Cells / Q000276:immunology*; D011819:Rabies Vaccines / Q000276:immunology; D014611:Vaccination; D055815:Young Adult
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011819:Rabies Vaccines