Hypofractionated stereotactic radiotherapy and radiosurgery for the treatment of patients with radioresistant brain metastases.
OBJECTIVE
To evaluate the efficacy of different radiotherapy treatment modalities in radioresistant brain metastasis.


METHODS
A retrospective analysis was conducted on 78 patients with brain metastases from melanoma, sarcoma, or renal cell carcinoma primary tumours who underwent radiosurgery (20 Gy) and/or hypofractionated stereotactic radiotherapy (6x4 Gy or 7x4 Gy) with or without whole-brain radiotherapy at our Center.


RESULTS
The actuarial median survival times for melanoma, renal cell carcinoma and sarcoma were 23, 22 and 7 months respectively, with a significant correlation to recursive partitioning analysis class.


CONCLUSIONS
Our results show that these treatments were effective both in symptom palliation and in improving survival, suggesting that although outcomes generally remained poor in this study population, it is possible and important to control intracranial brain metastases.
Scorsetti
Marta
M
O. U. of Radiotherapy and Radiosurgery, Istituto Clinico Humanitas, via Manzoni, 56 20089 Rozzano (MI), Italy. marta.scorsetti@humanitas.it
Facoetti
Angelica
A
Navarria
Piera
P
Bignardi
Mario
M
De Santis
Michela
M
Ninone
Stefania Agostino
SA
Lattuada
Paola
P
Urso
Gaetano
G
Vigorito
Sabrina
S
Mancosu
Pietro
P
Del Vecchio
Michele
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery / Q000628:therapy*; D002292:Carcinoma, Renal Cell / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery / Q000628:therapy; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy; D008297:Male; D008545:Melanoma / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery / Q000628:therapy; D008875:Middle Aged; D016634:Radiosurgery; D011880:Radiotherapy Planning, Computer-Assisted; D012189:Retrospective Studies; D012509:Sarcoma / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery / Q000628:therapy; D055815:Young Adult