Cinacalcet for hyperparathyroidism in pregnancy and puerperium.
The efficacy and safety of various modes of medical treatment for primary hyperparathyroidism (PHPT) in pregnancy is largely unknown. This report describes two cases of PHPT in pregnancy that were temporarily treated with the calcimimetic cinacalcet. The first case was diagnosed in the 31st week of pregnancy. The patient was asymptomatic and had an albumin-corrected total calcium level (Ca(corr)) of 3.24 mmol/l. As serum calcium was only mildly elevated it was decided to postpone surgery to the postpartum period. Cinacalcet was started immediately after delivery to prevent a postpartum surge in serum calcium. The second patient presented with hypertension and symptomatic hypercalcemia (Ca(corr) 3.96 mmol/l) in the 32nd week of pregnancy. Surgery was postponed because of suspected pheochromocytoma. Treatment with a combination of cinacalcet and calcitonin reduced serum Ca(corr) to 3.0 mmol/l. This report describes the monitoring of mother and child, and explores the pros and cons of the use of calcimimetics during pregnancy and puerperium.
Department of Internal Medicine, Rijnstate Hospital, Arnhem, The Netherlands.
Carmen
C
Horjus
Inge
I
Groot
Darryl
D
Telting
Petra
P
van Setten
Adriaan
A
van Sorge
Christopher S
CS
Kovacs
Ad
A
Hermus
Hans
H
de Boer
D000328:Adult; D002116:Calcitonin / Q000627:therapeutic use; D000069449:Cinacalcet; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D007231:Infant, Newborn / Q000097:blood; D008297:Male; D009281:Naphthalenes / Q000627:therapeutic use*; D049590:Postpartum Period / Q000097:blood; D011247:Pregnancy / Q000097:blood; D011248:Pregnancy Complications / Q000097:blood / Q000188:drug therapy*; D016896:Treatment Outcome
D009281:Naphthalenes; D002116:Calcitonin; D000069449:Cinacalcet