A STUDY OF THE THERAPEUTIC MECHANISM OF ANTIPNEUMOCOCCIC SERUM ON THE EXPERIMENTAL DERMAL PNEUMOCOCCUS INFECTION IN RABBITS : I. THE PRESENCE IN ANTIPNEUMOCOCCIC SERUM OF A NON-ANTIBACTERIAL THERAPEUTIC FACTOR.
1. Antipneumococcic serum contains in addition to the antibodies against the various bacterial constituents, a non-antibacterial therapeutic factor. 2. The non-antibacterial factor has been separated from the antibacterial antibodies by absorption with homologous, heat-killed, virulent pneumococci. 3. The non-antibacterial factor is not type-specific; it is probably species-specific; it is not neutralized by concentrated pneumococcus broth culture filtrate. 4. The therapeutic effect of the non-antibacterial factor was demonstrated on the experimental, dermal pneumococcus infection of rabbits; this effect is demonstrable when it is administered per seor in conjunction with a certain subeffective dose of serum. 5. Evidence is presented for the assumption that the ultimate outcome of pneumococcus infection depends to a considerable extent upon this non-antibacterial factor.
Sabin
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Department of Bacteriology and Immunology, New York University and Bellevue Hospital Medical College, New York.