Effect of dihydralazine on the fluidity of erythrocyte membranes.
Dihydralazine, a drug used in the treatment of chronic hypertension was found to affect the mobility of fatty acid hydrocarbon chains followed by spin-labelling technique with the use of 5-, 12- and 16-doxylstearate. The effect of this drug on the membrane bilayer properties may result either from the reduction of the number of double bonds in fatty acid hydrocarbon chains, as was shown by the changes of d1/d and order parameters in the region of C(12) or from direct interactions of the drug with the polar head group region of the phospholipids as was shown by changes in the distance between nitroxyl groups without changes of the order parameter in the region of C(5).
University of Wrocław, Faculty of Chemistry, Wrocław, Poland.
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Maliszewska-Mazur
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Sikorski
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Jezierski