Naloxone-responsive acute dystonia and parkinsonism following general anaesthesia.
Various movement disorders such as dystonia may acutely develop during or at emergence from general anaesthesia in patients with or without pre-existing Parkinson disease. These movements are triggered by a variety of drugs including propofol, sevoflurane, anti-emetics, antipsychotics and opioids. The postulated mechanism involves an imbalance between dopaminergic and cholinergic neurotransmitters in the basal ganglia. We report an acute, severe and generalised dystonic reaction in an otherwise healthy woman at emergence from general anaesthesia, dramatically reversed by the administration of naloxone, pointing to a potential role of the fentanyl and morphine that the patient had received. Recent literature on the mechanisms of abnormal movements induced by opioids are discussed. The severity of the reaction with usual doses of opioids, in a patient with no prior history of parkinsonism, led to further investigation that demonstrated the possibility of an enhanced susceptibility to opioids, involving a genetically determined abnormal function of glycoproteine-P and catechol-O-methyltransferase.
Department of Anaesthesiology, Geneva University Hospitals and Faculty of Medicine, Genève, Switzerland. irene.iselin-chaves@hcuge.ch
I A
IA
Iselin-Chaves
H
H
Grötzsch
M
M
Besson
P R
PR
Burkhard
G L
GL
Savoldelli
D000208:Acute Disease; D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects*; D020821:Dystonic Disorders / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D006801:Humans; D009270:Naloxone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use; D020734:Parkinsonian Disorders / Q000139:chemically induced* / Q000188:drug therapy; D011183:Postoperative Complications / Q000139:chemically induced* / Q000188:drug therapy
D009292:Narcotic Antagonists; D009270:Naloxone