[Tissue engineering of cartilage and bone : growth factors and signaling molecules].
Modern tissue engineering concepts integrate cells, scaffolds, signaling molecules and growth factors. In tissue engineering of cartilage, the growth plate of the long bone represents an interesting, well-organized developmental structure, with a spatial distribution of chondrocytes in different proliferation and differentiation stages embedded in a scaffold of extracellular matrix components. The proliferation and differentiation of these chondrocytes is regulated by various hormonal and paracrine factors. This article discusses some important growth factors in the process of endochondral ossification and demonstrates how this information could be translated into a controlled release system for different tissue engineering strategies.
REPAIR-lab, Institut für Pathologie, Universitätsmedizin, Johannes Gutenberg-Universität, Langenbeckstrasse 1, 55101, Mainz, Deutschland. brochhausen@pathologie.klinik.uni-mainz.de
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Brochhausen
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Lehmann
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Zehbe
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Watzer
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Grad
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Meurer
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Kirkpatrick
D000818:Animals; D001842:Bone and Bones / Q000502:physiology*; D002356:Cartilage / Q000502:physiology*; D002454:Cell Differentiation; D019902:Chondrocytes / Q000166:cytology* / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D048091:Guided Tissue Regeneration / Q000639:trends; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D023822:Tissue Engineering / Q000639:trends*; D054457:Tissue Scaffolds / Q000639:trends
D016326:Extracellular Matrix Proteins; D036341:Intercellular Signaling Peptides and Proteins