Clofarabine for the treatment of adult acute myeloid leukemia.
Clofarabine, a next-generation deoxyadenosine analog, has demonstrated significant activity in patients with acute myeloid leukemia (AML). The single-agent activity compares favorably with that demonstrated by the current standard antileukemia agents. Clofarabine has been safely and effectively combined with other agents and will probably become an integral part of induction and/or consolidation regimens in AML. Current studies are underway to better define the role of clofarabine in younger and elderly patients with AML, and also explore development strategies for an oral formulation.
Thomas
Xavier
X
Hematology, Edouard Herriot Hospital, Hospices Civils de Lyon, place d'Arsonval, 69437, Lyon cedex 03, France. xavier.thomas@chu-lyon.fr
Raffoux
Emmanuel
E
Elhamri
Mohamed
M
Lobe
Ida
I
Cannas
Giovanna
G
Dombret
Hervé
H
D000227:Adenine Nucleotides / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001087:Arabinonucleosides / Q000627:therapeutic use*; D002648:Child; D002986:Clinical Trials as Topic; D000077866:Clofarabine; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*
D000227:Adenine Nucleotides; D000970:Antineoplastic Agents; D001087:Arabinonucleosides; D000077866:Clofarabine