[Clinical observation of effect of jiawei yupingfeng mixture for prevention and treatment of 100 children with repeated respiratory tract infection].
OBJECTIVE
To investigate the effect of Jiawei Yupingfeng Mixture (YPF) on repeated respiratory tract infection (RRTI) and its impacts on T-cell subsets, immunoglobulin and erythrocyte immune.


METHODS
Two hundred children with RRTI were assigned equally to two groups, the test group treated with YPF and the control group treated by transfer factor. The clinical efficacy, and the changes of T-cell subsets, immunoglobulin and erythrocyte immune before and after treatment were observed in 31 patients randomly selected from each group.


RESULTS
After treatment, the frequency of attacking was reduced and the course of attacking was shortened significantly in the test group as compared with before treatment and also with the control group (P < 0.01); IgG and IgA levels were improved in both groups, but the improvement was more significant in the test group (P<0.01, P<0.05); T-cell subsets indices, including CD3(+), CD4(+), CD8(+) and CD4(+)/CD8(+) ratio, all improved in the test group significantly (P <0.01), while in the control group, significant improvement only showed in rising of CD3(+) and CD4(+) (P <0.05, P <0.01), comparison between groups showed significant difference in terms of CD3(+), CD4(+) and CD8(+); in the control group, levels of C3b, RFER and RFIR were changed significantly (P<0.05, P<0.01), but the improvement of ICR was insignificant, while in the test group, the above indices were significant improved as compared with after treatment of the control group (P <0.01).


CONCLUSIONS
YPF plays a preventive and therapeutic role in children with RRTI by way of regulating the cellular and humoral immune.
Wang
Shao-Jie
SJ
Department of Chinese Medicine, Dalian Children's Hospital, Liaoning. wsj6136@163.com
Jiao
Cheng-Yuan
CY
Sun
Xiao-Di
XD
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007136:Immunoglobulins; D007223:Infant; D008297:Male; D012141:Respiratory Tract Infections / Q000276:immunology / Q000517:prevention & control*; D016176:T-Lymphocyte Subsets; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; D007136:Immunoglobulins; C532967:yupingfeng