INHIBITION OF THE SHWARTZMAN PHENOMENON.
The Shwartzman phenomenon can be inhibited by an intravenous injection of a potent bacterial filtrate within a few hours before or after the preparatory intradermal injection. The inhibitory effect is produced non-specifically by filtrates potent in the elicitation of the Shwartzman phenomenon, and it is of a transitory nature. The relation of the observation described to anaphylactic desensitization and to its clinical significance is discussed in this paper.
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Laboratories of The Mount Sinai Hospital, New York, and the Serochemical Institute of the Tokyo Imperial University Medical School, Tokyo, Japan.