Renal cell carcinoma associated with Xp11.2 translocations, report of a case.
Renal cell carcinomas (RCCs) associated with Xp11.2 translocations (Xp11.2 translocation RCCs) are rare and occur predominantly in children and adolescents. A case of such tumor in a 12-year boy is reported. Grossly the cut surface of the ill-defined mass was polychromatic, containing areas of hemorrhage and necrosis. Microscopically, the tumor was composed of epithelioid cells with clear to weakly eosinophilic cytoplasm arranged in nested, alveolar, and pseudopapillary formations. Immunohistochemically, the neoplastic cells were positive for transcription factor E3 and CD10. We concluded that this case was an Xp11.2 translocation RCC.
Jing
Hongbiao
H
Department of Pathology, Jinan General Hospital, Jinan Military Command, Jinan, People's Republic of China. jinghong.biao@hotmail.com
Tai
Yanhong
Y
Xu
Dazhou
D
Yang
Fan
F
Geng
Ming
M
D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002648:Child; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic