Vitamin D and ageing.
Within the past three to four decades a revolution has occurred in our understanding of vitamin D and its effects. Sundry laboratory and epidemiologic studies have revealed that the active metabolite of vitamin D controls and/or ameliorates various pathologies. As presented here, there is substantive evidence that vitamin D may play a positive and important role in the ageing process.This evidence arises from detailed consideration of various biological mechanisms and processes by which vitamin D operates as well as specific examples of its exerting control/amelioration of various human maladies which contribute to ageing. Arguments are advanced that vitamin D appears to play a major positive role in biogerontology by reducing susceptibility in the elderly to chronic degenerative diseases. It is strongly recommended that the positive role of vitamin D in ageing be taken into account by gerontologists and biogerontology researchers.
Hayes
Daniel P
DP
The Brooklyn Hospital Center, 121 Dekalb Avenue, Brooklyn, NY 11201, USA. dhayes@health.nyc.gov
D000375:Aging / Q000187:drug effects* / Q000378:metabolism*; D019587:Dietary Supplements; D006801:Humans; D008954:Models, Biological; D014807:Vitamin D / Q000008:administration & dosage* / Q000378:metabolism* / Q000493:pharmacokinetics
D014807:Vitamin D