Modelling apical constriction in epithelia using elastic shell theory.
Apical constriction is one of the fundamental mechanisms by which embryonic tissue is deformed, giving rise to the shape and form of the fully-developed organism. The mechanism involves a contraction of fibres embedded in the apical side of epithelial tissues, leading to an invagination or folding of the cell sheet. In this article the phenomenon is modelled mechanically by describing the epithelial sheet as an elastic shell, which contains a surface representing the continuous mesh formed from the embedded fibres. Allowing this mesh to contract, an enhanced shell theory is developed in which the stiffness and bending tensors of the shell are modified to include the fibres' stiffness, and in which the active effects of the contraction appear as body forces in the shell equilibrium equations. Numerical examples are presented at the end, including the bending of a plate and a cylindrical shell (modelling neurulation) and the invagination of a spherical shell (modelling simple gastrulation).
Oxford Centre for Industrial and Applied Mathematics, Mathematical Institute, Oxford, UK. gareth.wyn@gmail.com
Gareth Wyn
GW
Jones
S Jonathan
SJ
Chapman
D000818:Animals; D049108:Cell Enlargement; D003198:Computer Simulation; D055119:Elastic Modulus / Q000502:physiology; D047108:Embryonic Development / Q000502:physiology*; D004847:Epithelial Cells / Q000502:physiology*; D004848:Epithelium / Q000196:embryology* / Q000254:growth & development*; D006801:Humans; D008954:Models, Biological