Lorneic acids, trialkyl-substituted aromatic acids from a marine-derived actinomycete.
A marine-derived actinomyces strain (NPS554) isolated from a marine sediment sample collected from Miyazaki Harbor, Japan, at a depth of 38 m yielded two trialkyl-substituted aromatic acids, lorneic acid A (1) and lorneic acid B (2). The structures of the lorneic acids, which were elucidated by spectroscopic analysis, differed only in the side-chain, which contained either a conjugated double bond or a benzylic alcohol. Their structural differences affected inhibition activities against phosphodiesterase 5.
Central Research Laboratory, Nippon Suisan Kaisha, Ltd, 559-6 Kitano-machi Hachioji, Tokyo 192-0906, Japan. iwata@nissui.co.jp
Fumie
F
Iwata
Seizo
S
Sato
Takako
T
Mukai
Shoichi
S
Yamada
Jiro
J
Takeo
Akihisa
A
Abe
Takaaki
T
Okita
Hiroyuki
H
Kawahara
D039903:Actinobacteria / Q000737:chemistry; D001555:Benzene Derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001792:Blood Platelets / Q000201:enzymology; D006801:Humans; D007564:Japan; D008386:Marine Biology; D015394:Molecular Structure; D058986:Phosphodiesterase 5 Inhibitors
D001555:Benzene Derivatives; D058986:Phosphodiesterase 5 Inhibitors; C545425:lorneic acid A; C545426:lorneic acid B