Effects of short inter-stimulus intervals on olfactory and trigeminal event-related potentials.
CONCLUSIONS
Chemosensory event-related potentials (CSERPs) were identified in all measurements using the 20 s and the 10 s inter-stimulus interval (ISI) protocol, reducing the recording time to 75% or 57% compared with the standard protocol. A possible explanation for the rising CSERP amplitudes by shortening the ISI in CO(2) stimulation is due to a phenomenon known as trigeminal sensitization during repeated stimulation.


OBJECTIVE
CSERPs are influenced by the ISI. The aim of this study was to evaluate the changes in CSERPs by decreasing the ISI from 30 s to 20 s or 10 s, respectively.


METHODS
Ten normosmic healthy subjects participated this study. Phenyl ethyl alcohol (PEA), hydrogen sulphide (H(2)S) and carbon dioxide (CO(2)) were used in CSERP measurements with different ISI protocols (30 s (standard), 20 s and 10 s). Amplitudes and latencies of ISI protocols were submitted to ANOVA for repeated measurements and t tests for paired samples.


RESULTS
The amplitudes of CSERPs with PEA and H(2)S stimuli were decreasing with shortening the ISI significantly. In contrast, the highest amplitudes of trigeminal CSERPs were recorded with the 10 s ISI protocol with CO(2). The ANOVA revealed a significantly different effect of shortening the ISI on CSERPs on the right and the left side.
Kassab
Ahmed
A
National Institute of Laser Enhanced Sciences, Cairo University, Cairo, Egypt. ahmedkassab20052000@yahoo.com
Schaub
Friederike
F
Vent
Julia
J
Hüttenbrink
Karl-Bernd
KB
Damm
Michael
M
D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009812:Odorants; D009832:Olfactory Nerve / Q000502:physiology*; D018034:Olfactory Receptor Neurons / Q000502:physiology*; D011601:Psychophysics; D011930:Reaction Time / Q000502:physiology*; D012016:Reference Values; D012032:Refractory Period, Electrophysiological / Q000502:physiology*; D012684:Sensory Thresholds / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D014276:Trigeminal Nerve / Q000502:physiology*; D055815:Young Adult