Nosocomial outbreak of novel arenavirus infection, southern Africa.
A nosocomial outbreak of disease involving 5 patients, 4 of whom died, occurred in South Africa during September-October 2008. The first patient had been transferred from Zambia to South Africa for medical management. Three cases involved secondary spread of infection from the first patient, and 1 was a tertiary infection. A novel arenavirus was identified. The source of the first patient's infection remains undetermined.
Paweska
Janusz T
JT
National Institute for Communicable Diseases, Sandringham, South Africa.
Sewlall
Nivesh H
NH
Ksiazek
Thomas G
TG
Blumberg
Lucille H
LH
Hale
Martin J
MJ
Lipkin
W Ian
WI
Weyer
Jacqueline
J
Nichol
Stuart T
ST
Rollin
Pierre E
PE
McMullan
Laura K
LK
Paddock
Christopher D
CD
Briese
Thomas
T
Mnyaluza
Joy
J
Dinh
Thu-Ha
TH
Mukonka
Victor
V
Ching
Pamela
P
Duse
Adriano
A
Richards
Guy
G
de Jong
Gillian
G
Cohen
Cheryl
C
Ikalafeng
Bridget
B
Mugero
Charles
C
Asomugha
Chika
C
Malotle
Mirriam M
MM
Nteo
Dorothy M
DM
Misiani
Eunice
E
Swanepoel
Robert
R
Zaki
Sherif R
SR
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D001117:Arenaviridae Infections / Q000453:epidemiology*; D018050:Arenavirus / Q000145:classification / Q000235:genetics*; D016358:Contact Tracing; D003428:Cross Infection / Q000453:epidemiology*; D004196:Disease Outbreaks; D017809:Fatal Outcome; D005260:Female; D006482:Hemorrhagic Fevers, Viral / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012254:Ribavirin / Q000627:therapeutic use; D015024:Zambia / Q000453:epidemiology
D000998:Antiviral Agents; D012254:Ribavirin