Cancer genetics and reproduction.
Cancers of the reproductive organs (i.e., ovaries, uterus and testes), like other cancers, occur as a result of a multi-stage interaction of genetic and environmental factors. A small proportion of cancers of the reproductive organs occur as part of a recognised cancer syndrome, as a result of inheritance of mutations in highly penetrant cancer susceptibility genes (e.g., BRCA1, BRCA2, MLH1 or MSH2). Recognition of individuals and families with inherited cancer predisposition syndromes and individuals at high risk due to familial cancer clustering is fundamentally important for the management and treatment of the current cancer and for future prevention of further cancers for the individual and their extended family.
Hanson
Helen
H
Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG, UK. Helen.Hanson@icr.ac.uk <Helen.Hanson@icr.ac.uk>
Hodgson
Shirley
S
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D001478:Basal Cell Nevus Syndrome / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics; D016000:Cluster Analysis; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics; D019317:Evidence-Based Medicine; D005260:Female; D018703:Founder Effect; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D007585:Jews / Q000235:genetics; D008403:Mass Screening; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein / Q000235:genetics; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000517:prevention & control / Q000628:therapy; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D010051:Ovarian Neoplasms / Q000235:genetics; D010375:Pedigree; D010580:Peutz-Jeghers Syndrome / Q000235:genetics; D011110:Polymorphism, Genetic; D011159:Population Surveillance; D017410:Practice Guidelines as Topic; D011379:Prognosis; D012098:Reproduction; D012307:Risk Factors
D048868:Adaptor Proteins, Signal Transducing; D005819:Genetic Markers; C501486:MLH1 protein, human; D009687:Nuclear Proteins; C497172:MSH2 protein, human; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein