Pain management in critically ill obese patients.
Achieving pain control in critically ill patients is a challenging problem for the health care team, which becomes more challenging in morbidly obese patients. Obese patients may experience drug malabsorption and distribution, which may lead to either subtherapeutic or toxic drug levels. To manage pain effectively for the critically ill obese patient, nurses must have an understanding of how obesity alters a patient's physiologic response to injury and illness. In addition, nurses must be knowledgeable about physiologic pain mechanisms, types and manifestations of pain, differing patterns of drug absorption and distribution, pharmacokinetic properties of analgesic medications, and pain management strategies. This article explores factors affecting pharmacokinetics in obese patients, trends in pain management, and treatment strategies for the obese patient.
Astle
Sonia M
SM
Department of Critical Care, Inova Fairfax Hospital, 3300 Gallows Road, Falls Church, VA 22042, USA. Sonia.astle@inova.org
D000701:Analgesics, Opioid / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016638:Critical Illness; D006801:Humans; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D010146:Pain / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D010147:Pain Measurement
D000701:Analgesics, Opioid