[Human zona pellucida glycoproteins and their binding to sperm].
Human zona pellucida (hZP) plays a critical role in the recognition, binding of sperms and oocytes, induction of acrosomal exocytosis, and avoidance of polyspermy. Human ZP is composed of four glycoproteins designated as hZP1, hZP2, hZP3 and hZP4. This paper reviews the actions of native hZP or recombinant hZP on acrosomal exocytosis and sperm-ZP binding.
Department of Biochemistry, Shanghai Workers Medical College, Shanghai 200237, China.
Xiao-Mei
XM
Li
Chen
C
Xu
D000177:Acrosome / Q000502:physiology; D004527:Egg Proteins / Q000502:physiology*; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D013094:Spermatozoa / Q000502:physiology*; D000072216:Zona Pellucida Glycoproteins
D004527:Egg Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D000072216:Zona Pellucida Glycoproteins