Use of coagulant spray glue (Glubran 2) for aerostatic purposes in pulmonary parenchyma resections in pigs: a preliminary study.
BACKGROUND
The aim of our study was to test the aerostatic validity of a cyan-acrylic glue (Glubran 2), applied by means of a spray catheter, on an experimental pig model.


METHODS
15 young pigs were divided into three study groups of 5 based on surgical techniques: (1) atypical pulmonary resection with mechanical suturing and reinforcement with continuous suturing; (2) resection of the pulmonary parenchyma with a cold scalpel, followed by local application of Glubran 2; (3) atypical pulmonary resection with mechanical suturing followed by application of Glubran 2.


RESULTS
The mean aerostasis time was calculated at 3.5 +/- 1.26 s. The histopathological analysis did not show any particular differences when comparing the effects of the treatments carried out with Glubran 2 spray glue and the standard treatments. No statistically significant differences were recorded in the short- and medium-term survival of pigs treated with Glubran 2 compared with the respective control groups.


CONCLUSIONS
The application of Glubran 2 spray on wounds caused by pulmonary resections in pigs proved to have a rapid and effective influence for the purposes of aerostasis without significant differences in air losses and survivals.
Department of Thoracic Surgery, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy. fab_78_16l @ hotmail.com
F
F
Davoli
F
F
Sellitri
J
J
Brandolini
G
G
Dolci
A
A
Castagnoli
B
B
Bedetti
F
F
Stella
D000269:Adhesives / Q000008:administration & dosage*; D000818:Animals; D003487:Cyanoacrylates / Q000008:administration & dosage*; D005260:Female; D008168:Lung / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D023421:Models, Animal; D013510:Pulmonary Surgical Procedures / Q000379:methods; D013536:Suture Techniques; D013552:Swine / Q000601:surgery
D000269:Adhesives; D003487:Cyanoacrylates; C421461:glubran 2