Benzosceptrins A and B with a unique benzocyclobutane skeleton and nagelamide S and T from Pacific sponges.
Four new dimeric pyrrole-2-aminoimidazole alkaloids have been isolated from the Pacific marine sponges Agelas cf. mauritiana and Phakellia sp. They include the unusual C2 symmetrical benzosceptrins A (4) and B (5), which each possess a unique benzocyclobutane skeleton and nagelamides S (6) and T (7). Their structures and relative configuration were elucidated from spectroscopic data. Plausible biogenetic paths for these compounds are also proposed in this paper.
Centre de Recherche de Gif-sur-Yvette, Institut de Chimie des Substances Naturelles, UPR 2301, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
Jérôme
J
Appenzeller
Supriya
S
Tilvi
Marie-Thérèse
MT
Martin
Jean-François
JF
Gallard
Hoda
H
El-bitar
Elise Tran Huu
ET
Dau
Cécile
C
Debitus
Dominique
D
Laurent
Céline
C
Moriou
Ali
A
Al-Mourabit
D047230:Agelas / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D007093:Imidazoles / Q000737:chemistry / Q000302:isolation & purification*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010140:Pacific Ocean; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification*
D000470:Alkaloids; D007093:Imidazoles; D011758:Pyrroles; C545619:benzosceptrin A; C545620:benzosceptrin B