[Correlation of maternal serum and amniotic fluid leptin and insulin levels with neonatal birth weight].
BACKGROUND
Numerous studies correlated maternal serum and fetal cord Leptin Levels in pregnancy with new born weight (NBW) and maternal body mass index (BMI). However, there are only a few published studies concerning amniotic fluid leptin and its possible relationship to fetal growth and NBW.


OBJECTIVE
To correlate leptin and insulin in amniotic fluid and maternal serum collected at 16-20 gestational weeks to NBW.


METHODS
This was an observational study in which maternal serum Leptin, insulin, and amniotic fluid Leptin and insulin, studied from 70 healthy pregnant women undergoing amniocentesis for karyotyping, at 16-20 weeks gestation. NBW was correlated with maternal BMI and leptin and insulin Levels in maternal serum and amniotic fluid.


RESULTS
Maternal serum leptin was detected as the best predictor of NBW. Squared correlation coefficient, r2 = 0.09, was statistically significant (P < 0.01). Maternal BMI correlated significantly with serum Levels of insulin and leptin r2 = 0.16 and 0.27 respectively, P < 0.01.


CONCLUSIONS
In normal pregnancies, amniotic fluid Leptin correlates partially with NBW. Maternal serum leptin correlates significantly with NBW.
Department of Obstetrics and Gynecology, The Baruch Padeh Medical Center, Poriya, affiliated to the Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel. yperlitz@poria.health.gov.il
Yuri
Y
Perlitz
Sofia
S
Gtezer-Soltzman
Aviva
A
Peleg
Nesia
N
Lang
Benny
B
Almog
Moshe
M
Ben-Ami
D000653:Amniotic Fluid / Q000737:chemistry*; D001724:Birth Weight / Q000502:physiology*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D020738:Leptin / Q000097:blood / Q000378:metabolism*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second
D007328:Insulin; D020738:Leptin