IMMUNOLOGICAL RELATIONSHIPS OF CELL CONSTITUENTS OF ENCAPSULATUS PNEUMONIAE (FRIEDLANDER'S BACILLUS).
1. The soluble specific substance of Friedländer's bacillus is non-antigenic when dissociated from the cell. It is different for each type and it is highly reactive in the corresponding anti-S serum. 2. The nucleoprotein is antigenic, induces the species or protein antibody which reacts with capsule-free cells and protein derived from all types. Antiprotein sera do not react with either the encapsulated cell or the polysaccharide derived from it, and they offer no protection against infection. 3. Anti-R and antiprotein sera are identical in their behavior. 4. The carbohydrate of Friedländer's bacillus is demonstrable in filtrates of actively growing cultures and in the blood and urine of infected animals. 5. The protein is demonstrable in filtrates of only old, disintegrating cultures.
Hospital of The Rockefeller Institute for Medical Research.
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