Albumin/creatinine ratio for prediction of 24-hour albumin excretion of > or =2 g in manifest preeclampsia.
OBJECTIVE
To compare whether albumin/creatinine ratios obtained from random or 8-hour urine collected in different periods of day differ in prediction of albumin excretion > or =2 g in 24-hour urine collection in preeclampsia.


METHODS
From a total of 70 women, 24-hour urine collected by three consecutive periods of eight hours and three random urine samples were taken before each period. The variation of albumin-creatinine ratios in samples across the day was analyzed by the Friedman and inter-assay coefficient variation. For each sample, receiver operator characteristic (ROC) curves were constructed to determine an optimal albumin/creatinine ratio value in the prediction of albuminuria > or =2 g.


RESULTS
The albumin/creatinine ratio did not vary significantly over time when all samples pooled. However, there was considerable intra-individual variation in both random and timed urine samples. On ROC analysis, the albumin/creatinine ratio in both random and timed urine samples predicted the 24-hour urine results and there was no difference between samples in prediction of albuminuria > or =2 g. A single optimal cut-off point was not available between samples. The positive and negative predictive values for optimal cut-offs ranged from 48%-88% and 94%-100%, respectively.


CONCLUSIONS
The random urine albumin/creatinine ratio was a poor predictor for proteinuria a 2 g in patients with preeclampsia.
Department of Obstetrics and Gynecology, Ataturk University Faculty of Medicine, Erzurum, Turkey. atakanal@gmail.com
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Borekci
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Yapca
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Keles
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Kadanali
D000328:Adult; D000419:Albuminuria; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000652:urine*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012372:ROC Curve; D055815:Young Adult
D003404:Creatinine