Reducing the incidence of necrotizing enterocolitis in neonates with hypoplastic left heart syndrome with the introduction of an enteral feed protocol.
OBJECTIVE
Neonates with hypoplastic left heart syndrome are prone to gastrointestinal complications, including necrotizing enterocolitis, during initiation or advancement of enteral feeds. A feeding protocol was developed to standardize practice across a multidisciplinary team. The purpose of this study was to examine the impact of a standardized feeding protocol on the incidence of necrotizing enterocolitis and overall postoperative gastrointestinal morbidity.


METHODS
Retrospective case-control study.


METHODS
Cardiothoracic intensive care unit of a tertiary care children's hospital.


METHODS
Ninety-eight neonates with hypoplastic left heart syndrome admitted to the cardiothoracic intensive care unit after first-stage palliation.


METHODS
A retrospective chart review was performed. Two groups were analyzed: the preprotocol group (n = 52) was examined from January 2000 through December 31, 2001, and the postprotocol group (n = 46) from February 2002 through December 31, 2003.


RESULTS
The incidence of suspected or diagnosed necrotizing enterocolitis as defined by the modified Bell staging criteria was recorded. Data were also collected regarding postoperative day of enteral feed initiation, postoperative day full feeds attained, and postoperative hospital length of stay. Necrotizing enterocolitis was detected in 14 preprotocol (27%) and three postprotocol (6.5%) patients (p < .01). Enteral feeds were initiated later in the postprotocol group (7.5 vs. 5.5 days, p < .001), and number of days to full feeds was also later in the postprotocol group (7 vs. 4 days, p = .02). Hospital length of stay tended to be shorter in the postprotocol group (21.5 vs. 28 days, p = .25).


CONCLUSIONS
Measures directed at reducing the incidence of necrotizing enterocolitis may reduce morbidity in neonates with hypoplastic left heart syndrome and reduce cost by decreasing hospital length of stay. A standardized feeding protocol instituted to address these problems likely contributed to reducing the incidence of necrotizing enterocolitis in this high-risk population.
del Castillo
Sylvia L
SL
Division of Critical Care Medicine, Department of Anesthesiology Critical Care Medicine, Children's Hospital Los Angeles, USC Keck School of Medicine, Los Angeles, CA, USA. sdelcastillo@chla.usc.edu
McCulley
Mary E
ME
Khemani
Robinder G
RG
Jeffries
Howard E
HE
Thomas
Dan W
DW
Peregrine
Jamie
J
Wells
Winfield J
WJ
Starnes
Vaughn A
VA
Moromisato
David Y
DY
D016022:Case-Control Studies; D004750:Enteral Nutrition / Q000379:methods*; D004760:Enterocolitis / Q000517:prevention & control; D020345:Enterocolitis, Necrotizing / Q000517:prevention & control*; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008485:Medical Audit; D011184:Postoperative Period; D012189:Retrospective Studies