Successful treatment of immune reconstitution inflammatory syndrome in Whipple's disease using thalidomide.
A patient with classic Whipple's disease developed erythema nodosum leprosum-like lesions and fever one month after the beginning of an accurate therapy with trimethoprim-sulfamethoxazole. Immune reconstitution inflammatory syndrome was suspected, but corticosteroid therapy failed to improve the patient. Finally, thalidomide was used and successfully induced rapid improvement.
Lagier
Jean-Christophe
JC
Université de la Méditerranée, Unité des Rickettsies, URMITE CNRS-IRD UMR 6236, Faculté de Médecine, 27 Bd Jean Moulin, 13385 Marseille cedex 05, France.
Fenollar
Florence
F
Lepidi
Hubert
H
Liozon
Eric
E
Raoult
Didier
D
D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000188:drug therapy*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013792:Thalidomide / Q000627:therapeutic use*; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D008061:Whipple Disease / Q000188:drug therapy* / Q000276:immunology
D007166:Immunosuppressive Agents; D013792:Thalidomide; D015662:Trimethoprim, Sulfamethoxazole Drug Combination