Further studies on the frequency of colorectal cancer in Crohn's colitis: an 11-year survey in the Northwest Stockholm County.
BACKGROUND
The frequency of colorectal carcinomas (CRC) evolving in patients with Crohn's colitis (CC) was assessed at the Danderyds University Hospital (DUH), one of two large hospitals in Northwest Stockholm County (NWSC).


METHODS
A total of 121 patients with Crohn's disease (CD) were treated at this hospital between 1996 and 2006. All sections from colectomy specimens having CC and carcinoma were reviewed.


RESULTS
Of the 121 patients with CD, 79.4% (96/121) had CC. Of the 96 patients with CC, 6.3% (n=6) developed a CRC between 1996 and 2006.


CONCLUSIONS
Recent studies at the other large hospital in NWSC showed that during the same period (1996-2006) 7.4% (n=21) of the 282 patients with CC, developed a CRC. During this 11-year period, 7.1% (n=27) of the 378 patients with CC seen at the two hospitals that treat the vast majority of patients with CD in NWSC developed a CRC. By comparison, only 0.29% or 5,566 patients (age-adjusted) out of the 1,900,000 inhabitants in the entire Stockholm County developed a CRC during the same period. These results, obtained at a comparative time-interval in the County, substantiate several recent meta-analysis and population-based studies on the high cancer risk in patients with Crohn disease.
Rubio
Carlos A
CA
Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden. Carlos.Rubio@ki.se
Kapraali
Marjo
M
Befrits
Ragnar
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000473:pathology; D003424:Crohn Disease / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013548:Sweden / Q000453:epidemiology; D055815:Young Adult