The nuclear envelopathies and human diseases.
The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intriguing connections between the envelope components and nuclear processes. Here, we review the functions of the nuclear envelope in chromosome organization, gene expression, DNA repair and cell cycle progression, and correlate deficiencies in envelope function with human pathologies.
Chi
Ya-Hui
YH
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. ychi@nhri.org.tw
Chen
Zi-Jie
ZJ
Jeang
Kuan-Teh
KT
D000818:Animals; D002453:Cell Cycle; D002875:Chromosomes / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004260:DNA Repair; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D034904:Lamin Type A / Q000378:metabolism; D034921:Lamin Type B / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D009685:Nuclear Envelope / Q000378:metabolism*; D034881:Nuclear Lamina / Q000378:metabolism*; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism
D034904:Lamin Type A; D034921:Lamin Type B; D028861:Nuclear Pore Complex Proteins