Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans.
In humans, the kinetics of the appearance of memory B cells and plasma cells during primary immunization are not well defined. In this study, we assessed the primary B-cell response of rabies-antigen naive volunteers during a 3-dose course of rabies vaccine compared with the B-cell response to a booster dose of rabies vaccine given to previously immunized volunteers. After a single dose of vaccine, in the naive group plasma and memory B cells appeared later (peak at day 10) than in the primed group (peak at day 7) and were at lower frequency. The most rapid responses (day 4) were detected after a third immunization in the naive group. This is the first study to document the detailed kinetics of the plasma cell and memory B-cell responses to immunization in adult humans and to demonstrate differences in the responses that relate to the preexisting immune status of the persons.
Blanchard-Rohner
Geraldine
G
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Oxford, United Kingdom. Geraldine.BlanchardRohner@paediatrics.ox.ac.uk
Pulickal
Anoop S
AS
Jol-van der Zijde
Cornelia M
CM
Snape
Matthew D
MD
Pollard
Andrew J
AJ
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D007156:Immunologic Memory / Q000276:immunology*; D008875:Middle Aged; D010950:Plasma Cells / Q000276:immunology*; D011819:Rabies Vaccines / Q000276:immunology; D014611:Vaccination; D055815:Young Adult
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011819:Rabies Vaccines