[Exploration into the preparation of placebos used in Chinese medicinal clinical trial].
Placebo-controlled clinical trials have been more and more emphasized in traditional Chinese medicine (TCM) researches, while the preparation of TCM placebos is still to be improved. For this work, some elements should be taken into consideration comprehensively, including the design of clinical trial, the characteristics of researched disease, the nature of testing drugs, and the way of medication, etc. And the technological process for placebo manufacturing should be selected properly depending upon the basis of the above elements. Un-biased foodstuff is good as excipient for TCM placebos preparation. The placebo should be made in dosage-form similar to that of the testing drug as possible, if there are difficulties for simulating them in appearance and smell completely. However, its potential pharmacological activity meeting to the acceptance of researchers should be ensured.
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing. txdly@sina.com
Xu-Dong
XD
Tang
Li-Qun
LQ
Bian
Rui
R
Gao
D002986:Clinical Trials as Topic; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods*; D010919:Placebos / Q000592:standards*
D004365:Drugs, Chinese Herbal; D010919:Placebos