Exploring synthetic avenues for the effective synthesis of selenium- and tellurium-containing multifunctional redox agents.
Various human illnesses, including several types of cancer and infectious diseases, are related to changes in the cellular redox homeostasis. During the last decade, several approaches have been explored which employ such disturbed redox balances for the benefit of therapy. Compounds able to modulate the intracellular redox state of cells have been developed, which effectively, yet also selectively, appear to kill cancer cells and a range of pathogenic microorganisms. Among the various agents employed, certain redox catalysts have shown considerable promise since they are non-toxic on their own yet develop an effective, often selective cytotoxicity in the presence of the 'correct' intracellular redox partners. Aminoalkylation, amide coupling and multicomponent reactions are suitable synthetic methods to generate a vast number of such multifunctional catalysts, which are chemically diverse and, depending on their structure, exhibit various interesting biological activities.
Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, PO Box 151150, D-66123, Saarbruecken, Germany.
Susanne
S
Mecklenburg
Saad
S
Shaaban
Lalla A
LA
Ba
Torsten
T
Burkholz
Thomas
T
Schneider
Britta
B
Diesel
Alexandra K
AK
Kiemer
Anne
A
Röseler
Katja
K
Becker
Jörg
J
Reichrath
Alexandra
A
Stark
Wolfgang
W
Tilgen
Muhammad
M
Abbas
Ludger A
LA
Wessjohann
Florenz
F
Sasse
Claus
C
Jacob
D000478:Alkylation / Q000187:drug effects; D000577:Amides / Q000737:chemistry; D000586:Amination / Q000187:drug effects; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D001665:Binding Sites; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D010084:Oxidation-Reduction / Q000187:drug effects; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000166:cytology / Q000187:drug effects; D012643:Selenium / Q000737:chemistry*; D013691:Tellurium / Q000737:chemistry*; D014249:Trichophyton / Q000187:drug effects
D000577:Amides; D000975:Antioxidants; D012643:Selenium; D013691:Tellurium