Shaping tubular carriers for intracellular membrane transport.
The particular compositions of the intracellular membrane organelles rely on the proteins and lipids received frequently through membrane trafficking. The delivery of these molecules is driven by the membrane-bound organelles known as transport carriers (TCs). Advanced microscopy approaches have revealed that TC morphology ranges from small vesicles to complex tubular membrane structures. These tubular TCs (TTCs) support effectively both sorting and transport events within the biosynthetic and endocytic pathways, while a coherent picture of the processes that define the formation and further fate of TTCs is still missing. Here, we present an overview of the mechanisms operating during the TTC life cycle, as well as of the emerging role of tubular carriers in different intracellular transport routes.
Polishchuk
Roman S
RS
Unit of Membrane Sorting and Biogenesis, Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro, Chieti, Italy. polish@negrisud.it
Capestrano
Mariagrazia
M
Polishchuk
Elena V
EV
D000818:Animals; D001692:Biological Transport; D004705:Endocytosis; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism* / Q000648:ultrastructure; D022161:Transport Vesicles / Q000378:metabolism* / Q000648:ultrastructure