[Association of blood glucose fluctuation with the pain sensation in patients with painful diabetic neuropathy].
OBJECTIVE
To investigate the relationship between blood glucose fluctuation and the pain sensation in patients with painful diabetic neuropathy.


METHODS
The severity of pain in 16 patients with painful diabetic neuropathy was assessed using visual analog scale (VAS), and according to the results, the patients were divided into mild to moderate pain group and severe pain group. The blood glucose of the patients were monitored continuously for 72 h using a continuous glucose monitoring system, and the MBG, SD, DMMG, MAGE, and AUCPG were obtained with the FBG and HbA1C tested.


RESULTS
The SD, DMMG, and MAGE of the severe pain group were all significantly higher than those of the mild to moderate pain group (P<0.05), and no significant difference was found in MBG, FBG or HbA1c between the two groups.


CONCLUSIONS
The blood glucose fluctuation is associated with the severity of the pain degree, and effective control of the blood glucose fluctuation helps prevent and treat painful diabetic neuropathy.
Department of Endocrinology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. doctor_cy@163.com
Ying
Y
Cao
Yao-ming
YM
Xue
Jie
J
Shen
Fang
F
Gao
Xiang-rong
XR
Luo
Xia-jun
XJ
Fu
Ji-min
JM
Li
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D010146:Pain / Q000097:blood / Q000209:etiology*; D010147:Pain Measurement; D017288:Pain Threshold
D001786:Blood Glucose