Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins.
Maintenance of appropriate iron homeostasis in the brain is important, but the mechanisms involved in brain iron uptake are incompletely understood. Here, we have analyzed where messenger RNAs that encode iron transport proteins are expressed in the brain, using the Allen Brain atlas, and we conclude that several important iron transporters are highly expressed in the choroid plexus. Based on recent estimates of the surface area of the choroid plexus and on MRI imaging studies of manganese uptake in the brain, we propose that the choroid plexus may have a much greater role than has been previously appreciated in brain iron transport.
Molecular Medicine Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. rouault@mail.nih.gov
Tracey A
TA
Rouault
De-Liang
DL
Zhang
Suh Young
SY
Jeong
D000818:Animals; D001271:Atlases as Topic; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D001923:Brain Chemistry / Q000502:physiology; D001931:Brain Mapping; D002196:Capillaries / Q000166:cytology / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism*; D027682:Cation Transport Proteins / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D002831:Choroid Plexus / Q000166:cytology / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism; D005293:Ferritins / Q000378:metabolism; D015870:Gene Expression / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D007501:Iron / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism; D000098742:Ferroportin; D000099236:Solute Carrier Family 11, Member 2
D002352:Carrier Proteins; D027682:Cation Transport Proteins; D002570:Ceruloplasmin; D005293:Ferritins; D007501:Iron; D012333:RNA, Messenger; D000098742:Ferroportin; D000099236:Solute Carrier Family 11, Member 2