African tick bite Fever in a Taiwanese traveler returning from South Africa: molecular and serologic studies.
We report the first imported case of African tick bite fever (ATBF) in a patient from Taiwan who returned from a 10-day trip to South Africa. Diagnosis was confirmed by polymerase chain reaction (PCR) from eschar biopsies. Portions of rickettsial ompA (491 bp) and ompB (273 bp) genes were amplified and subsequent sequencing of PCR product showed its 100% identity with R. africae. Microimmunofluorescence (MIF) assay of patient's serum on Days 14 and 46 after the onset of illness revealed IgG seroconversion when tested with spotted fever group (SFG) rickettsiae antigens, including R. africae. The patient clinically improved on the third day of 14-day treatment with a combination of ciprofloxacin and minocycline. Based on the patient's travel history and chronology of clinical symptoms, we strongly suspect that the tick-biting event occurred in Kruger National Park.
Tsai
Kun-Hsien
KH
Research and Diagnostic Center, Centers for Disease Control, Department of Health, Taipei, Taiwan, R.O.C.
Lu
Hsiu-Ying
HY
Huang
Jyh-Hsiung
JH
Fournier
Pierre-Edouard
PE
Mediannikov
Oleg
O
Raoult
Didier
D
Shu
Pei-Yun
PY
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001733:Bites and Stings; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012282:Rickettsia Infections / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D012698:Serologic Tests; D013019:South Africa / Q000453:epidemiology; D013624:Taiwan; D017282:Tick-Borne Diseases / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D013987:Ticks; D014195:Travel
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G