Delayed onset nodules from liquid injectable silicone: report of a case, evaluation of associated histopathology and results of treatment with minocycline and celocoxib.
Although liquid injectable silicone is safe for the majority of patients treated, there are a few individuals for whom this treatment has been problematic. The problems that arise include migration and granuloma formation. In some instances the granulomas may arise years after the injections. Treatment of these granulomas typically involves the use of steroids. However, the complications associated with long-term steroid usage, as well as the limited efficacy in some patients, have prompted clinicians to seek alternative treatments. This article presents the case of a woman who had delayed granuloma formation to liquid injectable silicone treated with a combination of minocycline and celocoxib. The histology of this case, as well as potential mechanisms of action for the treatment, are also presented.
Beer
Kenneth
K
Palm Beach Esthetic Dermatology and Laser Center, West Palm Beach and Jupiter, FL 33401, USA. KenBeer@aol.com
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000068579:Celecoxib; D004359:Drug Therapy, Combination; D005260:Female; D005548:Foreign-Body Migration / Q000188:drug therapy*; D015745:Granuloma, Foreign-Body / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D007267:Injections; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use; D011720:Pyrazoles / Q000627:therapeutic use; D012828:Silicones / Q000009:adverse effects*; D013449:Sulfonamides / Q000627:therapeutic use; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D012828:Silicones; D013449:Sulfonamides; D008911:Minocycline; D000068579:Celecoxib