T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors.
Elite controllers or suppressors are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain undetectable viral loads. In this study, we show that most elite suppressors do not experience significant changes in T cell counts over a 10-year period. Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation.
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Ahmad R
AR
Sedaghat
Darius A
DA
Rastegar
Karen A
KA
O'Connell
Jason B
JB
Dinoso
Claus O
CO
Wilke
Joel N
JN
Blankson
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D000998:Antiviral Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D018655:Lymphocyte Count; D008875:Middle Aged; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D019562:Viral Load / Q000187:drug effects
D000998:Antiviral Agents