In vivo interactions between BZP and TFMPP (party pill drugs).
OBJECTIVE
This study explores potential drug-drug interactions between BZP and TFMPP. This was achieved by comparing the metabolism and pharmacokinetics of BZP and TFMPP when taken together with previously published data on their individual metabolism and pharmacokinetics.


METHODS
Blood and urine samples were collected from seven participants given a combined dose of BZP (100 mg) and TFMPP (30 mg) and analysed by LC-MS in order to quantify the concentrations of BZP, TFMPP, and their major hydroxylated metabolites 3-OH BZP, 4-OH BZP, and 4-OH TFMPP.


RESULTS
The metabolic profiles of both drugs were altered when co-administered. Both BZP and TFMPP lost one metabolite, 3-OH BZP and 4-OH TFMPP, respectively. Some differences in the pharmacokinetic properties of TFMPP were also noted.


CONCLUSIONS
Metabolic interactions between BZP and TFMPP are clearly observed in this study along with some changes to the pharmacokinetics of TFMPP. As these drugs are often co-administered, the interactions between them are both relevant and concerning. Awareness of these interactions can assist clinicians in understanding toxicities relating to the co-administration of BZP and TFMPP or other party pill drugs.
Antia
Ushtana
U
Ushtana Antia, Research Assistant, School of Pharmacy, University of Auckland, Private Bag 92019, Auckland, New Zealand. u.antia@auckland.ac.nz
Tingle
Malcolm D
MD
Russell
Bruce R
BR
D000284:Administration, Oral; D000328:Adult; D004347:Drug Interactions; D005500:Follow-Up Studies; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects* / Q000493:pharmacokinetics; D008297:Male; D009520:New Zealand / Q000453:epidemiology; D010879:Piperazines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015995:Prevalence; D012016:Reference Values; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage / Q000493:pharmacokinetics; D021241:Spectrometry, Mass, Electrospray Ionization; D019966:Substance-Related Disorders / Q000097:blood / Q000453:epidemiology* / Q000652:urine; D055815:Young Adult
D013287:Illicit Drugs; C461488:N-benzylpiperazine; D010879:Piperazines; D017366:Serotonin Receptor Agonists; C018406:1-(3-trifluoromethylphenyl)piperazine