Autophagy proteins promote hepatitis C virus replication.
Autophagy is a fundamental process for anti-viral defense. Not surprisingly, viruses have developed strategies to subvert or use autophagy for their own benefit. In cell culture, autophagy proteins are proviral factors that favor initiation of hepatitis C virus (HCV) infection. Autophagy proteins are required for translation of incoming viral RNA. We propose that autophagy factors might support the delivery of incoming RNA to the translation apparatus and/or the recruitment of cellular factors required to initiate HCV translation.
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA. mdreux@scripps.edu
Marlène
M
Dreux
Francis V
FV
Chisari
D001343:Autophagy; D011992:Endosomes / Q000378:metabolism / Q000821:virology; D016174:Hepacivirus / Q000502:physiology*; D006526:Hepatitis C / Q000378:metabolism / Q000821:virology; D006801:Humans; D011506:Proteins / Q000378:metabolism*; D014779:Virus Replication / Q000502:physiology*
D011506:Proteins