Novel bla(TEM)-positive ampicillin-susceptible strains of Haemophilus influenzae.
Two ampicillin-susceptible strains of Haemophilus influenzae were found to carry blaTEM genes. In one strain ampicillin susceptibility was explained by poor expression of a functional TEM-1 enzyme from a putative weak promoter created by a mutation in the promoter region of the gene, and in the other by production of an inactive mutant TEM enzyme.
School of Human Life Sciences, University of Tasmania, Newnham Drive, Launceston, Tasmania 7250, Australia. Stephen.Tristram@utas.edu.au
Stephen G
SG
Tristram
D000667:Ampicillin / Q000494:pharmacology*; D000668:Ampicillin Resistance / Q000235:genetics*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000201:enzymology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D011401:Promoter Regions, Genetic / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics*
D000900:Anti-Bacterial Agents; D000667:Ampicillin; D001618:beta-Lactamases; C034413:beta-lactamase TEM-1