Pathema: a clade-specific bioinformatics resource center for pathogen research.
Pathema (http://pathema.jcvi.org) is one of the eight Bioinformatics Resource Centers (BRCs) funded by the National Institute of Allergy and Infectious Disease (NIAID) designed to serve as a core resource for the bio-defense and infectious disease research community. Pathema strives to support basic research and accelerate scientific progress for understanding, detecting, diagnosing and treating an established set of six target NIAID Category A-C pathogens: Category A priority pathogens; Bacillus anthracis and Clostridium botulinum, and Category B priority pathogens; Burkholderia mallei, Burkholderia pseudomallei, Clostridium perfringens and Entamoeba histolytica. Each target pathogen is represented in one of four distinct clade-specific Pathema web resources and underlying databases developed to target the specific data and analysis needs of each scientific community. All publicly available complete genome projects of phylogenetically related organisms are also represented, providing a comprehensive collection of organisms for comparative analyses. Pathema facilitates the scientific exploration of genomic and related data through its integration with web-based analysis tools, customized to obtain, display, and compute results relevant to ongoing pathogen research. Pathema serves the bio-defense and infectious disease research community by disseminating data resulting from pathogen genome sequencing projects and providing access to the results of inter-genomic comparisons for these organisms.
Brinkac
Lauren M
LM
J Craig Venter Institute, Rockville, MD 20850, USA.
Davidsen
Tanja
T
Beck
Erin
E
Ganapathy
Anuradha
A
Caler
Elisabet
E
Dodson
Robert J
RJ
Durkin
A Scott
AS
Harkins
Derek M
DM
Lorenzi
Hernan
H
Madupu
Ramana
R
Sebastian
Yinong
Y
Shrivastava
Susmita
S
Thiagarajan
Mathangi
M
Orvis
Joshua
J
Sundaram
Jaideep P
JP
Crabtree
Jonathon
J
Galens
Kevin
K
Zhao
Yongmei
Y
Inman
Jason M
JM
Montgomery
Robert
R
Schobel
Seth
S
Galinsky
Kevin
K
Tanenbaum
David M
DM
Resnick
Adam
A
Zafar
Nikhat
N
White
Owen
O
Sutton
Granger
G
D000595:Amino Acid Sequence; D000818:Animals; D001424:Bacterial Infections / Q000175:diagnosis / Q000382:microbiology*; D003141:Communicable Diseases / Q000382:microbiology*; D019295:Computational Biology / Q000379:methods* / Q000639:trends; D030541:Databases, Genetic; D016680:Genome, Bacterial; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods; D020407:Internet; D008969:Molecular Sequence Data; D054579:National Institute of Allergy and Infectious Diseases (U.S.); D017386:Sequence Homology, Amino Acid; D012984:Software; D014481:United States