The role of angiogenesis in the pathogenesis of psoriasis.
Psoriasis is a multifactorial skin disorder with known systemic consequences. While most recent studies point to a predominantly Th17-driven process, psoriasis also lies at the crossroads linking the pathways of angiogenesis and inflammation. Mediators such as VEGF and angiopoietin-2 play significant roles in the pathophysiology and may even account for the maintenance of the chronic inflammatory state. Targets in this shared pathway may offer alternative avenues for therapy.
Department of Dermatology, Emory University School of Medicine, Atlanta Veterans Administration Hospital, Atlanta, GA 30322, USA.
Ramon Alvin
RA
Chua
Jack L
JL
Arbiser
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D009389:Neovascularization, Pathologic / Q000276:immunology* / Q000378:metabolism; D011565:Psoriasis / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000276:immunology* / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D016207:Cytokines; D007155:Immunologic Factors; D042461:Vascular Endothelial Growth Factor A