Leptin: back and forward.
The discovery of leptin resulted in a gear change in obesity research. Exploiting its therapeutic potential has proved to be a long game, although encouraging progress is now being made with leptin monotherapy in conditions of relative deficiency, and with combination therapy against common obesity. Leptin's role in early brain development constitutes an exciting area for mechanistic study with potential therapeutic implications.
Mercer
Julian
J
Division of Obesity and Metabolic Health, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
D000375:Aging / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000235:genetics / Q000502:physiology; D001921:Brain / Q000254:growth & development / Q000378:metabolism; D004435:Eating / Q000235:genetics / Q000502:physiology; D006801:Humans; D020738:Leptin / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use*; D051379:Mice; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism
D020738:Leptin