Optic nerve head (ONH) topographic analysis by stratus OCT in normal subjects: correlation to disc size, age, and ethnicity.
OBJECTIVE
To study optic nerve head (ONH) topography parameters measured by Stratus optical coherence tomography (OCT) in normal subjects and to analyze ONH data for differences in relation to disc size, ethnicity, and age.


METHODS
Three hundred sixty-seven normal subjects underwent Stratus optical coherence tomography ONH measurement using the fast optic disc scan protocol software package 3.0. Only ONH scans meeting specific qualification criteria were included for data analysis ensuring appropriate scan quality and reliability. ONH topographic parameters of qualified scans were analyzed for differences in regards to optic disc size, age, and ethnicity.


RESULTS
Two hundred and twelve qualified ONH scans were included for data analysis. Mean disc area was 2.27+/-0.41 mm and optic cup area, rim area, and horizontal integrated rim width increased with disc size, whereas vertical integrated rim area did not. Vertical integrated rim area, horizontal integrated rim width, and rim area decreased and cup area increased with age. Mean optic disc area was larger in African-Americans as compared with Hispanics or Whites and this difference was statistically significant.


CONCLUSIONS
Optic cup area, rim area, and horizontal integrated rim width correlated to disc size. Vertical integrated rim area, horizontal integrated rim width, rim area, and cup area, changed with age. African-American optic discs had larger disc area measurements as compared with Whites optic discs and this difference was statistically significant.
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Barbara C
BC
Marsh
Louis B
LB
Cantor
Darrell
D
WuDunn
Joni
J
Hoop
Jennifer
J
Lipyanik
Vincent Michael
VM
Patella
Donald L
DL
Budenz
David S
DS
Greenfield
Jonathan
J
Savell
Joel S
JS
Schuman
Rohit
R
Varma
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000033:anatomy & histology*; D011446:Prospective Studies; D012016:Reference Values; D041623:Tomography, Optical Coherence