ANP and insulin presence in human foetal pancreas.
Aim of this work is to investigate the presence of Atrial natriuretic peptide (ANP) and insulin in human foetal pancreas from not diabetic and diabetic mothers. The data literature evidenced relationship between serum ANP and insulin. The our work carried out on sections immunostained for ANP and insulin showed positivity for ANP and insulin in beta-cells of pancreas from diabetic mothers, while positivity for insulin in beta-cells of foetuses from not diabetic mothers. Results indicate that the insulin presence stimulates the ANP synthesis in pancreas of human foetuses from diabetic mothers.
Dipartimento di Medicina sperimentale, Sezione Anatomia umana, Università di Palermo. bigvalentino@libero.it
Biagio
B
Valentino
Diego
D
Lipari
Giovanni
G
Peri
Luana
L
Lipari
Alessandro
A
Valentino
Elvira
E
Farina
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D048909:Diabetes Complications / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D005333:Fetus / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism; D007515:Islets of Langerhans / Q000378:metabolism / Q000503:physiopathology; D010179:Pancreas / Q000378:metabolism* / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism* / Q000503:physiopathology
D001786:Blood Glucose; D007328:Insulin; D009320:Atrial Natriuretic Factor