Clinical outcomes in patients with ICU-related pancreatitis.
OBJECTIVE
To identify risk factors predictive of intensive care unit (ICU) mortality in patients with ventilator-related pancreatitis. The clinical outcomes of patients with ventilator-related pancreatitis were compared with those of patients with pancreatitis-related respiratory failure as well as controls.


METHODS
One hundred and forty-eight patients with respiratory failure requiring mechanical ventilation and concomitant acute pancreatitis were identified from a prospectively collected dataset of 9108 consecutive patients admitted with respiratory failure over a period of five years. Sixty patients met the criteria for ventilator-related pancreatitis, and 88 (control patients), for pancreatitis-related respiratory failure.


RESULTS
Mortality rate in ventilator-related pancreatitis was comparable to that in ICU patients without pancreatitis by case-control methodology (P = 0.544). Multivariate logistic regression analysis identified low PaO(2)/FiO(2) (OR: 1.032, 95% CI: 1.006-1.059, P = 0.016) as an independent risk factor for mortality in patients with ventilator-related pancreatitis. The mortality rate in patients with ventilator-related pancreatitis was lower than that in patients with acute pancreatitis-related respiratory failure (P < 0.001).


CONCLUSIONS
We found that low PaO(2)/FiO(2) was an independent clinical parameter predictive of ICU mortality in patients with ventilator-related pancreatitis.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, No. 123, Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 83301, Taiwan, China.
Chia-Cheng
CC
Tseng
Wen-Feng
WF
Fang
Yu-Hsiu
YH
Chung
Yi-Hsi
YH
Wang
Ivor S
IS
Douglas
Meng-Chih
MC
Lin
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010100:Oxygen / Q000097:blood; D010195:Pancreatitis / Q000209:etiology / Q000401:mortality* / Q000628:therapy; D012121:Respiration, Artificial / Q000009:adverse effects / Q000401:mortality*; D012131:Respiratory Insufficiency / Q000209:etiology / Q000401:mortality* / Q000628:therapy; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
D010100:Oxygen