MHC class I: an unexpected role in neuronal plasticity.
For the nervous system to translate experience into memory and behavior, lasting structural change at synapses must occur. This requirement is clearly evident during critical periods of activity-dependent neural development, and accumulating evidence has established a surprising role for the major histocompatibility complex class I (MHCI) proteins in this process.
Bio-X and Departments of Biology and Neurobiology, James H. Clark Center, 318 Campus Drive W1.1, Stanford University, Stanford CA 94305-5437, USA. cshatz@stanford.edu
Carla J
CJ
Shatz
D000818:Animals; D001921:Brain / Q000276:immunology / Q000502:physiology*; D015870:Gene Expression; D005805:Genes, MHC Class I; D015395:Histocompatibility Antigens Class I / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008959:Models, Neurological; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000276:immunology / Q000502:physiology*; D011971:Receptors, Immunologic / Q000378:metabolism; D013569:Synapses / Q000502:physiology*
D015395:Histocompatibility Antigens Class I; D011971:Receptors, Immunologic