Multicentric plasmocytic Castleman's disease with polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome and coexistent human herpes virus-6 infection--a possible relationship.
Authors report a case of Castleman's disease (CD) with polyneuropathy, organomegaly, endocrinopathy, M protein, skin change (POEMS) syndrome. According to the present knowledge, these two rare conditions are often induced by Human Herpes Vírus- 8 (HHV-8) or by Human Immunodefeciency Virus, separately or in combination. In this case, however, HHV-6 viral DNA had been detected in the blood and lymph node samples by PCR. The authors conclude that the modulation of immune functions by HHV-6 might be responsible for the development of CD and POEMS syndrome in the referred case.
Third Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
Adám
A
Fazakas
Márta
M
Csire
György
G
Berencsi
Agota
A
Szepesi
András
A
Matolcsy
Lajos
L
Jakab
István
I
Karádi
Judit
J
Várkonyi
D000368:Aged; D001402:B-Lymphocytes / Q000378:metabolism / Q000821:virology; D001853:Bone Marrow / Q000473:pathology / Q000821:virology; D005871:Castleman Disease / Q000097:blood / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology / Q000821:virology; D004279:DNA, Viral / Q000097:blood; D005260:Female; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology; D008727:Methotrexate / Q000627:therapeutic use; D016878:POEMS Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000821:virology; D010266:Paraproteins / Q000032:analysis; D011241:Prednisone / Q000627:therapeutic use; D019349:Roseolovirus Infections / Q000150:complications*; D013967:Thyroiditis, Autoimmune / Q000150:complications; D014803:Vitamin B Complex / Q000627:therapeutic use
D004279:DNA, Viral; D010266:Paraproteins; D014803:Vitamin B Complex; D011241:Prednisone; D008727:Methotrexate