Comparative analysis of hepatocellular carcinoma in men and dogs.
Concerning the important differences in the ethiopathology of hepatocelular carcinomas (HCC) in humans and dogs, our work describes the expression of epidermal growth factor receptor (EGFr), cytokeratine 19 (CK19), vascular endothelial growth factor (VEGF) and transforming growth factor beta receptor (TGFbeta-r) in tumors arising in both species. Investigation included 25 cases of human and 8 cases of dog tumors. All human cases were noted in cirrhotic livers, while in dogs the tissue adjacent to tumor was not changed. In humans in two cases hepatitis B virus (HBV) and in one case hepatitis C virus (HCV) were determined. Investigation showed lack of TGFbeta-r reaction in six cases of canine HCC, while in humans only one case was negative. In most tumors specific hepatocyte antigen Hepatocyte Paraffin 1 marker (Hep Par 1) was mainly positive with markedly decreased reaction compared to the normal hepatocytes, while cytokeratine 19 for billiary epithelium was negative. The result of our investigation rise the question about the possible role of tumor suppressor gene TGFbeta-r in the development of HCC in dogs and in the same time emphasizes its importance in human diseases.
Department of General Pathology and Pathological Morphology, Veterinary Faculty Zagreb, University of Zagreb, Zagreb, Croatia. zgrabar@vef.hr
Zeljko
Z
Grabarević
Marijana
M
Corić
Sven
S
Seiwerth
Petar
P
Dzaja
Branka
B
Artuković
Andrea Gudan
AG
Kurilj
Ana
A
Beck
Marko
M
Hohsteter
Ivan-Conrado
IC
Sostarić-Zuckermann
Luka
L
Brcić
Irena
I
Hrstić
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000737:chemistry* / Q000473:pathology*; D004285:Dogs; D066246:ErbB Receptors / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D053539:Keratin-19 / Q000032:analysis; D008113:Liver Neoplasms / Q000737:chemistry* / Q000473:pathology*; D008297:Male; D018125:Receptors, Transforming Growth Factor beta / Q000032:analysis; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
D053539:Keratin-19; D018125:Receptors, Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; D066246:ErbB Receptors