In vitro activity of thimerosal against ocular pathogenic fungi.
The in vitro activity of thimerosal versus those of amphotericin B and natamycin was assessed against 244 ocular fungal isolates. The activity of thimerosal against Fusarium spp., Aspergillus spp., and Alternaria alternata was 256 times, 512 times, and 128 times, respectively, greater than that of natamycin and 64 times, 32 times, and 32 times, respectively, greater than that of amphotericin B. Thimerosal's antifungal activity was significantly superior to those of amphotericin B and natamycin against ocular pathogenic fungi in vitro.
Xu
Yan
Y
Department of Ocular Pharmacology, Henan Eye Institute, 7 Weiwu Road, Zhengzhou 450003, China. xuyan990301@yahoo.com.cn
Pang
Guangren
G
Zhao
Dongqing
D
Gao
Chuanwen
C
Zhou
Lutan
L
Sun
Shengtao
S
Wang
Bingliang
B
D000528:Alternaria / Q000187:drug effects; D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D015821:Eye Infections, Fungal / Q000382:microbiology*; D005658:Fungi / Q000187:drug effects*; D005670:Fusarium / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D010866:Natamycin / Q000494:pharmacology; D013849:Thimerosal / Q000494:pharmacology*
D000935:Antifungal Agents; D013849:Thimerosal; D000666:Amphotericin B; D010866:Natamycin