Mitochondrial metabolism and cancer.
Historically, it has been assumed that glycolytic metabolism, not mitochondrial metabolism, is essential for tumor cell proliferation. However, most tumor cells have functional mitochondria, and recent studies suggest that the citric acid cycle (TCA) cycle intermediates are precursors for synthesis of nucleotides, lipids, and amino acids. Here we review the accumulating evidence that mitochondrial metabolism plays an essential role in tumor cell proliferation.
Weinberg
Frank
F
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Medical School, Chicago, IL 60611-2010, USA.
Chandel
Navdeep S
NS
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002952:Citric Acid Cycle / Q000502:physiology; D005973:Glutamine / Q000378:metabolism; D006019:Glycolysis / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D009249:NADP / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species; D005973:Glutamine; D009249:NADP; D000255:Adenosine Triphosphate