Targeting HSP70 for cancer therapy.
In a recent issue of Molecular Cell, Leu et al. (2009) demonstrate that a chemical inhibitor of HSP70 exerts prominent tumor-selective cytotoxic effects, thereby lending further support to the notion that non-oncogene addiction constitutes a promising target for anticancer therapy.
Galluzzi
Lorenzo
L
INSERM, U848, F-94805 Villejuif, France; Institut Gustave Roussy, F-94805 Villejuif, France.
Giordanetto
Fabrizio
F
Kroemer
Guido
G
D000818:Animals; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000628:therapy*; D013449:Sulfonamides / Q000494:pharmacology
D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; D013449:Sulfonamides