Graves' disease associated with primary systemic sclerosis.
Graves' disease can be associated with other autoimmune disorders. Primary systemic sclerosis (PSS) is such a disease characterised by multi-organ fibrosis. Abnormal thyroid antibody titres and hypothyroidism as well as hyperthyroidism have been observed in PSS patients. Specific and idiopathic inflammatory disorders are an important differential diagnosis in Graves'orbitopathy (GO). Mycophenolate mofetil (MM) is an immunosuppressive drug which depletes guanosin nucleotides in proliferating B-and T-lymphocytes. We describe the effect of MM on the endocrine orbitopathy of a patient with PSS.
Wimmersberger
Yves
Y
Hôpital Cantonal Genève, HUG, Clinique d'Ophtalmologie, Switzerland.
Zuercher
Doris
D
D001379:Azathioprine / Q000627:therapeutic use; D000077300:Bosentan; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006111:Graves Disease / Q000150:complications* / Q000532:radiotherapy; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D011507:Proteinuria / Q000150:complications; D011928:Raynaud Disease / Q000150:complications / Q000188:drug therapy; D012595:Scleroderma, Systemic / Q000150:complications* / Q000188:drug therapy; D013449:Sulfonamides / Q000627:therapeutic use
D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D013449:Sulfonamides; D003520:Cyclophosphamide; D009173:Mycophenolic Acid; D001379:Azathioprine; D000077300:Bosentan; D008727:Methotrexate