Two subgroups of schizophrenia identified by systematic cognitive neuropsychiatric mapping.
The description of the heterogeneous phenomenological, pathophysiological, and etiological nature of schizophrenia is under way; however, the relationships between heterogeneity levels are still unclear. We performed a robust cross-sectional study, including a systematic neuropsychological battery, assessment of clinical symptoms, neurological soft signs, morphogenetic anomalies and smell identification, and measurement of event-related potentials on 50 outpatients with schizophrenia in their compensated states. An explorative fuzzy cluster analysis revealed two subgroups in this sample that could be distinguished from each other on symptomatological, cognitive and neurological levels. The patterns of cognitive dysfunctions and neurological developmental anomalies equally indicate that there may be hemispherical differences between the patients belonging to the different clusters.
Department of Psychiatry, University of Szeged, 6 Semmelweis str., 6725, Szeged, Hungary. szendi@nepsy.szote.u-szeged.hu
István
I
Szendi
Mihály
M
Racsmány
Csongor
C
Cimmer
Gábor
G
Csifcsák
Zoltán Ambrus
ZA
Kovács
György
G
Szekeres
Gabriella
G
Galsi
Ferenc
F
Tóth
Attila
A
Nagy
Edit Anna
EA
Garab
Krisztina
K
Boda
Gergely
G
Gulyás
József Géza
JG
Kiss
József
J
Dombi
Csaba
C
Pléh
Zoltán
Z
Janka
D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000465:Algorithms; D016000:Cluster Analysis; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology; D003265:Contingent Negative Variation / Q000502:physiology; D004569:Electroencephalography / Q000379:methods; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D011336:Probability; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000145:classification / Q000150:complications / Q000175:diagnosis; D012565:Schizophrenic Psychology; D012903:Smell / Q000502:physiology; D018709:Statistics, Nonparametric; D055815:Young Adult