ETIOLOGY OF OROYA FEVER : XIII. CHEMOTHERAPY IN EXPERIMENTAL BARTONELLA BACILLIFORMIS INFECTION.
The therapeutic effect of several antiparasitic chemicals on experimental verruga peruana is described. The drugs were administered by intravenous injection according as the nodules (1) were already developed to an approximate maximum, or (2) were still in the active period of growth. The effect of the drugs was different under the two circumstances of their administration. When they were given after the maturity of the nodules they hastened the regressive process, but when given during active growth of the lesions no action whatever was detected. Bartonella bacilliformis in culture is acted upon injuriously by a number of the chemicals employed in the therapeutic tests, the most active being formalin and neutroflavine.
Laboratories of The Rockefeller Institute for Medical Research.
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Noguchi