Direct chemoselective synthesis of glyconanoparticles from unprotected reducing glycans and glycopeptide aldehydes.
Chemoselective oxime coupling was used for facile conjugation of unprotected, reducing glycans and glycopeptide aldehydes with core?shell gold nanoparticles carrying reactive aminooxy groups on the organic shell.
IGM-Bioorganic Chemistry, Centre for Carbohydrate Recognition and Signalling, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark.
Mikkel B
MB
Thygesen
Kasper K
KK
Sørensen
Emiliano
E
Cló
Knud J
KJ
Jensen
D000447:Aldehydes / Q000737:chemistry*; D006020:Glycopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D010091:Oximes / Q000737:chemistry; D011134:Polysaccharides / Q000138:chemical synthesis / Q000737:chemistry*
D000447:Aldehydes; D006020:Glycopeptides; D010091:Oximes; D011134:Polysaccharides; D006046:Gold