Successful treatment of immune reconstitution inflammatory syndrome in Whipple's disease using thalidomide.
A patient with classic Whipple's disease developed erythema nodosum leprosum-like lesions and fever one month after the beginning of an accurate therapy with trimethoprim-sulfamethoxazole. Immune reconstitution inflammatory syndrome was suspected, but corticosteroid therapy failed to improve the patient. Finally, thalidomide was used and successfully induced rapid improvement.
Université de la Méditerranée, Unité des Rickettsies, URMITE CNRS-IRD UMR 6236, Faculté de Médecine, 27 Bd Jean Moulin, 13385 Marseille cedex 05, France.
Jean-Christophe
JC
Lagier
Florence
F
Fenollar
Hubert
H
Lepidi
Eric
E
Liozon
Didier
D
Raoult
D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000188:drug therapy*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013792:Thalidomide / Q000627:therapeutic use*; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D008061:Whipple Disease / Q000188:drug therapy* / Q000276:immunology
D007166:Immunosuppressive Agents; D013792:Thalidomide; D015662:Trimethoprim, Sulfamethoxazole Drug Combination