Is Hsp27 a marker of myocardial ischaemia?
BACKGROUND
Heat shock protein (Hsp) 27 expression in cardiomyocytes increases in response to ischaemia. The extracellular release of Hsp27 from cardiomyocytes is proportional to its intracellular levels.


OBJECTIVE
To assess the influence of significant coronary artery disease (CAD), which by definition results in chronic myocardial ischaemia, on blood serum levels of Hsp27.


METHODS
Blood serum levels of Hsp27 in 62 patients with at least 50% lumen diameter narrowing in at least one main epicardial coronary artery on angiography and in 21 controls with normal coronaries were measured.


RESULTS
Patients with CAD tended to have higher serum level of Hsp27 than controls [0.463 (0.158-0.809) vs. 0.184 (0.099-0.337) ng/ml, p = 0.084]. Serum Hsp27 level in patients with CAD affecting more than a single vessel was significantly increased [0.529 (0.192-1.004) ng/ml] compared with controls (p = 0.035) and with one artery narrowed [0.276 (0.087-0.549) ng/ml, p = 0.041]. No correlation between Hsp27 serum levels and severity of coronary narrowings assessed by Gensini score was found (r = 0.21, p = 0.11).


CONCLUSIONS
Serum level of Hsp27 seems to be a potential marker of myocardial ischaemia caused by advanced 2- or 3-vessel CAD.
Józefowicz-Okonkwo
Grazyna
G
Medical University, Lodz, Poland. gokonkwo@zdn.umed.lodz.pl
Wierzbowska-Drabik
Karina
K
Kasielski
Marek
M
Trzos
Ewa
E
Goraca
Anna
A
Nowak
Dariusz
D
Kasprzak
Jarosław
J
Krzemińska-Pakuła
Maria
M
D015415:Biomarkers / Q000378:metabolism; D002908:Chronic Disease; D017023:Coronary Angiography; D003326:Coronary Circulation; D005260:Female; D055551:HSP27 Heat-Shock Proteins / Q000378:metabolism*; D006360:Heat-Shock Proteins; D006801:Humans; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones; D017202:Myocardial Ischemia / Q000097:blood* / Q000175:diagnosis; D032383:Myocytes, Cardiac / Q000378:metabolism*
D015415:Biomarkers; D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones