hMOF, a KAT(8) with many lives.
Dynamic lysine acetylation regulates proteins involved in diverse cellular processes, with individual enzymes often acetylating multiple substrates. Here, Li et al. (2009) show that the substrate specificity of hMOF/MYST1/KAT8 is controlled by differential interaction with two mutually exclusive partners.
Biomedical Graduate Studies, University of Pennsylvania, Philadelphia, PA 19104, USA.
Hestia S
HS
Mellert
Steven B
SB
McMahon
D000107:Acetylation; D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D051548:Histone Acetyltransferases / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000737:chemistry / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D051017:Apoptosis Regulatory Proteins; C438378:BBC3 protein, human; D006657:Histones; D046912:Multiprotein Complexes; D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; D051548:Histone Acetyltransferases; C496552:KAT8 protein, human