In vivo activities of recombinant divercin V41 and its structural variants against Listeria monocytogenes.
Recombinant divercin RV41 (DvnRV41) and its structural variants were used in this study to assess their antilisterial activities in vivo in mice challenged intravenously with Listeria monocytogenes EGDe. Treatment with DvnRV41 before and after infection permitted a conclusion as to the capacities of this peptide to retain activity and reduce growth of L. monocytogenes EGDe. Moreover, the use of structural variants for the first time in vivo and the reductions of their activities confirmed the importance of certain amino acids in antilisterial activity.
Rihakova
Jitka
J
UMR INRA SECALIM 1014 ENITIAA/ENVN, Rue de la Géraudière, BP 82225, 44322 Nantes Cedex 3, France.
Cappelier
Jean-Michel
JM
Hue
Isabelle
I
Demnerova
Katerina
K
Fédérighi
Michel
M
Prévost
Hervé
H
Drider
Djamel
D
D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents; D001430:Bacteriocins / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D003470:Culture Media; D005260:Female; D008089:Listeria monocytogenes / Q000187:drug effects* / Q000254:growth & development; D008088:Listeriosis / Q000188:drug therapy* / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D011994:Recombinant Proteins; D013154:Spleen / Q000382:microbiology
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D003470:Culture Media; D010455:Peptides; D011994:Recombinant Proteins; C116372:divercin V41