Angiomatoid fibrous histiocytoma in a six-year-old child.
We report a case of AFH presenting as an asymptomatic subcutaneous nodule on the arm of a 6-year-old boy. AFH is a fibrohistiocytic tumor of intermediate malignancy. Predominantly seen in children and young adults, AFH presents as a deep dermal or subcutaneous nodule usually on the extremities. The histology is characterized by a fibrous capsule, surrounding lymphocytic infiltrate and blood-filled cystic spaces lined by flattened tumor cells. AFH cells express desmin, epithelial membrane antigen, and CD 68 in over 60% of cases; they are negative for myogenin, MYOD1, and endothelial markers. Rate of local recurrence is 2% to 20%. The metastatic rate is 1%. Management is with wide surgical excision and careful follow-up.
Northeastern Ohio Universities College of Medicine, Rootstown, OH, USA.
Christina
C
Cernik
Deepa
D
Channaiah
Julian
J
Trevino
D001706:Biopsy; D002648:Child; D006391:Hemangioma / Q000473:pathology* / Q000601:surgery; D051677:Histiocytoma, Malignant Fibrous / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery