A pilot trial of pramlintide home usage in adolescents with type 1 diabetes.
OBJECTIVE
The objective of this study was to evaluate the safety and efficacy of home pramlintide use in adolescents with type 1 diabetes.


METHODS
This was a randomized, 28-day pilot trial of pramlintide (maximum dose: 30 microg per meal) in 10 adolescents aged 13 to 17 years. End points included changes in hemoglobin A1c (HbA1c) values, body weight, and postprandial peak blood glucose levels and area under the curve on continuous glucose monitoring.


RESULTS
Changes in HbA1c values, body weight, and total insulin dose declined in the treatment group compared with the control group (bootstrapped, P <or= .02 for each). The treatment group also demonstrated lower average dinner area under the curve (P = .02) and lower maximum breakfast (P = .03) and dinner (P = .02) postprandial blood glucose values.


CONCLUSIONS
Pramlintide can help some adolescents to decrease postprandial hyperglycemia, HbA1c values, body weight, and insulin dosages. Additional large-scale trials should now be considered.
Kishiyama
Christopher M
CM
Department of Pediatrics, University of Colorado, Aurora, Colorado 80045, USA.
Burdick
Patricia L
PL
Cobry
Erin C
EC
Gage
Victoria L
VL
Messer
Laurel H
LH
McFann
Kim
K
Chase
H Peter
HP
D000293:Adolescent; D000682:Amyloid / Q000627:therapeutic use*; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007332:Insulin Infusion Systems; D058228:Islet Amyloid Polypeptide; D008297:Male; D019518:Postprandial Period
D000682:Amyloid; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D058228:Islet Amyloid Polypeptide; C105254:pramlintide