Non-canonical peptides bound to MHC.
Central to the initiation of a T cell dependent immune response is the recognition of major histocompatibility complex (MHC) class I or class II molecules (in humans termed HLA and in mice termed H-2) bound to antigenic peptide. T cell receptors (TCR) have programmed specificity for particular peptide/MHC complexes, which ensures focused immune responses are generated against the antigen source. To design effective peptide based vaccines a comprehensive understanding of the specific interactions between MHC molecules and peptide, and of TCR recognition of MHC/peptide is valuable. We place particular emphasis on non-canonical bound peptides and their use in immunotherapy studies.
Macfarlane Burnet Institute for Medical Research, Centre for Immunology, Immunology and Vaccine, and Structural Immunology Laboratories, VIC, Australia.
Stephanie L
SL
Day
Paul A
PA
Ramsland
Vasso
V
Apostolopoulos
D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology*; D010455:Peptides / Q000276:immunology* / Q000378:metabolism; D011485:Protein Binding; D013601:T-Lymphocytes / Q000276:immunology
D000596:Amino Acids; D010455:Peptides