Separation of conformational isomers of bouvardin by high-pressure liquid chromatography.
Bouvardin, a bicyclic hexapeptide, was found to exhibit a solvent-dependent conformational distribution. HPLC was utilized to separate the two different conformers whose distribution ratio was dependent on the solvent of injection.
Hoffmann
J J
JJ
College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, USA.
Torrance
S J
SJ
Cole
J R
JR
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D010456:Peptides, Cyclic / Q000302:isolation & purification*; D011487:Protein Conformation; D013237:Stereoisomerism
D010456:Peptides, Cyclic; C018234:bouvardin