[Hereditary non-polyposis colorectal cancer associated with hereditary gastric cancer. A case report.].
The information regarding the association of gastric cancer and type 2 Lynch syndrome is limited. Previous studies have reported that both entities may be present in the same individual in less than 5% of the cases. The most frequent form of hereditary colorectal cancer is the Lynch syndrome or Hereditary Non-polyposic Colorectal Cancer, which is associated with germ-line mutation mostly of two genes, MLH1 and MSH2, which account for almost 90 percent of all identified mutations. The hereditary diffuse gastric cancer syndrome is caused by a germ-line mutation in the E-cadherin (CDH1) gene; only about 50 families with this syndrome have been reported. We present a case report of a patient who was diagnosed with both syndromes.
Castañeda-Argáiz
R
R
Médico pasante del Servicio Social, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.
González-Contreras
Q H
QH
Medina-Franco
H
H
Rodríguez-Zentner
H A
HA
Tapia-Cid de León
H
H
Vergara-Fernández
O
O
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000230:Adenocarcinoma / Q000150:complications* / Q000151:congenital / Q000235:genetics; D000714:Anastomosis, Surgical; D015820:Cadherins / Q000235:genetics; D003082:Colectomy; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications* / Q000235:genetics; D013505:Digestive System Surgical Procedures; D018095:Germ-Line Mutation; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D013274:Stomach Neoplasms / Q000150:complications* / Q000151:congenital / Q000235:genetics
D048868:Adaptor Proteins, Signal Transducing; D015820:Cadherins; C501486:MLH1 protein, human; D009687:Nuclear Proteins; C497172:MSH2 protein, human; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein