Efficacy of posaconazole in a murine disseminated infection by Candida tropicalis.
We evaluated the efficacy of posaconazole against Candida tropicalis in a systemic infection model with immunosuppressed mice. Posaconazole at 50 mg/kg of body weight/day prolonged the survival of mice and reduced the fungal tissue burden of mice infected with any of the five strains tested, with the exception of one strain that had a high MIC against this drug. Our results demonstrate the efficacy of posaconazole in the treatment of invasive murine infection caused by C. tropicalis.
Mariné
Marçal
M
Unitat de Microbiologia, Facultat de Medicina, IISPV, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201, Reus, Spain.
Pastor
F Javier
FJ
Guarro
Josep
J
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001822:Body Burden; D041022:Candida tropicalis / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D007165:Immunosuppression Therapy; D053208:Kaplan-Meier Estimate; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D013534:Survival; D014230:Triazoles / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole