Novel bla(TEM)-positive ampicillin-susceptible strains of Haemophilus influenzae.
Two ampicillin-susceptible strains of Haemophilus influenzae were found to carry blaTEM genes. In one strain ampicillin susceptibility was explained by poor expression of a functional TEM-1 enzyme from a putative weak promoter created by a mutation in the promoter region of the gene, and in the other by production of an inactive mutant TEM enzyme.
Tristram
Stephen G
SG
School of Human Life Sciences, University of Tasmania, Newnham Drive, Launceston, Tasmania 7250, Australia. Stephen.Tristram@utas.edu.au
D000667:Ampicillin / Q000494:pharmacology*; D000668:Ampicillin Resistance / Q000235:genetics*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000201:enzymology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D011401:Promoter Regions, Genetic / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics*
D000900:Anti-Bacterial Agents; D000667:Ampicillin; D001618:beta-Lactamases; C034413:beta-lactamase TEM-1