Mechanistic studies on a dipeptide-promoted asymmetric cyclopropanation of unfunctionalized olefins.
This paper describes mechanistic studies on a dipeptide-promoted asymmetric cyclopropanation system for unfunctionalized olefins. Zinc species generated from the deprotonation of the N-H of the dipeptide ligand have been investigated by NMR and X-ray structure studies and are likely to be responsible for asymmetric cyclopropanation. ZnI(2) plays an important role in promoting the reaction.
Long
Jiang
J
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
Xu
Liang
L
Du
Haifeng
H
Li
Kai
K
Shi
Yian
Y
D000475:Alkenes / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003500:Cyclization; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D004151:Dipeptides / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
D000475:Alkenes; D003521:Cyclopropanes; D004151:Dipeptides; D008024:Ligands