Antibacterial, antifungal, and antiviral activities of some flavonoids.
Antibacterial and antifungal activities of six plant-derived flavonoids representing two different structural groups were evaluated against standard strains of Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis and their drug-resistant isolates, as well as fungi (Candida albicans, C. krusei) using the microdilution broth method. Herpes simplex virus Type-1 and Parainfluenza-3 virus were employed for antiviral assessment of the flavonoids using Madin-Darby bovine kidney and Vero cell lines. Ampicillin, gentamycin, ofloxacin, levofloxacin, fluconazole, ketoconazole, acyclovir, and oseltamivir were used as the control agents. All tested compounds (32-128 microg/ml) showed strong antimicrobial and antifungal activities against isolated strains of P. aeruginosa, A. baumanni, S. aureus, and C. krusei. Rutin, 5,7-dimethoxyflavanone-4'-O-beta-D-glucopyranoside and 5,7,3'-trihydroxy-flavanone-4'-O-beta-D-glucopyranoside (0.2-0.05 microg/ml) were active against PI-3, while 5,7-dimethoxyflavanone-4'-O-[2''-O-(5'''-O-trans-cinnamoyl)-beta-D-apiofuranosyl]-beta-D-glucopyranoside (0.16-0.2 microg/ml) inhibited potently HSV-1.
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Turkey. didem@gazi.edu.tr
Didem Deliorman
DD
Orhan
Berrin
B
Ozçelik
Selda
S
Ozgen
Fatma
F
Ergun
D000818:Animals; D000935:Antifungal Agents / Q000032:analysis / Q000494:pharmacology*; D000998:Antiviral Agents / Q000032:analysis / Q000494:pharmacology*; D001419:Bacteria; D002417:Cattle; D002460:Cell Line; D002522:Chlorocebus aethiops; D005419:Flavonoids / Q000032:analysis / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006801:Humans; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D014709:Vero Cells; D014780:Viruses / Q000187:drug effects
D000935:Antifungal Agents; D000998:Antiviral Agents; D005419:Flavonoids; D010936:Plant Extracts