THE RELATIONSHIP OF SULFAPYRIDINE, NICOTINIC ACID, AND COENZYMES TO THE GROWTH OF STAPHYLOCOCCUS AUREUS.
Our studies indicate that sulfapyridine modifies the normal metabolism of a bacterium. Coenzymes inhibit the effect of sulfapyridine on the growth of staphylococcus in Knight's medium. Nicotinic acid does not interfere with the action of sulfapyridine under the same conditions. The possible relation of sulfapyridine, nicotinic acid, and coenzymes in relation to bacterial growth is discussed.
Department of Medicine of the Presbyterian Hospital and the College of Physicians and Surgeons, Columbia University, New York.
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Coburn