The effect of amitriptyline on inhibitory avoidance in mice is dose-dependent.
The purpose of the present work was to study the dose-effect relationship of the antidepressant amitriptyline on inhibitory avoidance in male and female mice. Subjects received physiological saline or 2.5, 5, 10 or 20 mg/kg of amitriptyline hydrochloride 30 min before the training phase, and were subjected to the test phase 24 h later. Results showed a clear impairing effect of amitriptyline on inhibitory avoidance in both male and female mice, and that the effect is dose-dependent.
Parra
Andrés
A
Facultad de Psicología, Universidad de Valencia, Spain. andres.parra@uv.es
Vinader-Caerols
Concepción
C
Ferrer-Añó
Aránzazu
A
Urquiza
Adoración
A
Monleón
Santiago
S
D000639:Amitriptyline / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D011897:Random Allocation; D011930:Reaction Time / Q000187:drug effects
D000639:Amitriptyline