Gastric choriocarcinoma admixed with an alpha-fetoprotein-producing adenocarcinoma and separated adenocarcinoma.
We report a case of gastric choriocarcinoma admixed with an alpha-fetoprotein (AFP)-producing adenocarcinoma. A 70-year-old man was hospitalized for gastric cancer that was detected during screening by esophagogastroduodenoscopy (EGD). Initial laboratory data showed the increased serum level of AFP and EGD revealed a 5-cm ulcerofungating mass in the greater curvature of the gastric antrum. The patient underwent radical subtotal gastrectomy with D2 lymph node dissection and Billroth II gastrojejunostomy. Histopathological evaluation confirmed double primary gastric cancer: gastric choriocarcinoma admixed with an AFP-producing adenocarcinoma and separated adenocarcinoma. At 2 wk postoperatively, his human chorionic gonadotropin and AFP levels had reduced and six cycles of adjuvant chemotherapy were initiated. No recurrence or distant metastasis was observed at 4 years postoperatively.
Center for Gastric Cancer, National Cancer Center, 111 Jeongbalsanro, Ilsandong-Gu, Goyang-Si, Gyeonggi-Do 410-769, South Korea.
Bang Wool
BW
Eom
So-Youn
SY
Jung
Hongman
H
Yoon
Myeong-Cherl
MC
Kook
Keun-Won
KW
Ryu
Jun-Ho
JH
Lee
Young-Woo
YW
Kim
D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D002822:Choriocarcinoma / Q000175:diagnosis* / Q000473:pathology; D006063:Chorionic Gonadotropin / Q000378:metabolism; D005743:Gastrectomy; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology; D016896:Treatment Outcome; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins