INCREASED VASCULAR PERMEABILITY INDUCED BY HUMAN PLASMIN.
Preparations of plasminogen, soluble in aqueous media, increased vascular permeability in guinea pig skin when activated by streptokinase or urokinase. The permeability-enhancing effect was inhibited by soybean trypsin inhibitor but not by triprolidine. Permeability-enhancing activity evolved when plasmin was incubated with fractions of plasma rich in prokinin. The experiments described suggest that plasmin exerts its permeability-increasing effect through the elaboration of kinins.
Department of Medicine, Western Reserve University School of Medicine, and University Hospitals, Cleveland.
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Ratnoff