Recent advances of fluorescent technologies for drug discovery and development.
Recent progresses in the development of fluorescent technologies become a reliable device for drug discovery research. The fluorescence tools offer attractive options for an opportunity to visualize the effects of drug candidates in the cells. The fluorescent tools, such as fluorescent protein, are regularly used in a range of drug discovery processes. A better understanding and use of fluorescent technologies facilitate drug discovery research faster and can open up new applications. Therefore, we have provided information about some new generation fluorescent reagents (GFP and fluorophores). This review illustrates how fluorescent technologies and fluorescent tools are contributing to the drug discovery process mainly high-throughput screening (HTS), disease mechanism based target discovery, disease-genes-based target discovery, 'target classes' based target candidate discovery, physiology-based drug discovery, genomics-based drug discovery, target validation and their future perspectives.
Chakraborty
Chiranjib
C
Department of Marine Biotechnology and Resources, College of Marine Science and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohisung, Taiwan.
Hsu
Chi-Hsin
CH
Wen
Zhi-Hong
ZH
Lin
Chan-Shing
CS
D000818:Animals; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation; D005453:Fluorescence; D005456:Fluorescent Dyes; D005823:Genetics; D023281:Genomics; D049452:Green Fluorescent Proteins; D006801:Humans; D011955:Receptors, Drug / Q000187:drug effects
D005456:Fluorescent Dyes; D011955:Receptors, Drug; D049452:Green Fluorescent Proteins