Ring-extended derivatives of gramicidin S with furanoid sugar amino acids in the turn region have enhanced antimicrobial activity.
Knijnenburg
Annemiek D
AD
Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands.
Spalburg
Emile
E
de Neeling
Albert J
AJ
Mars-Groenendijk
Roos H
RH
Noort
Daan
D
Grotenbreg
Gijsbert M
GM
van der Marel
Gijsbert A
GA
Overkleeft
Herman S
HS
Overhand
Mark
M
D000596:Amino Acids / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002241:Carbohydrates / Q000737:chemistry; D004912:Erythrocytes / Q000187:drug effects; D006096:Gramicidin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D017433:Protein Structure, Secondary
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D002241:Carbohydrates; D006096:Gramicidin