Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.
Acetyl-coenzyme A carboxylase alpha (ACACA) single-nucleotide polymorphism (SNP) (rs2229416) was significantly associated with hypertriglyceridemia, during exploration of antipsychotic direct effects on lipids. Neuropeptide Y (NPY) gene (rs1468271) and ACACB gene (rs2241220) SNPs were significantly associated with severe hypercholesterolemia. In the same sample (173 patients on olanzapine, quetiapine, chlorpromazine or mirtazapine [increasing the risk of hyperlipidemia] and 184 controls taking other antipsychotics), three (rs1266175, rs12453407 and rs9906543) of eight additional ACACA SNPs were significantly associated with hypertriglyceridemia in those taking drugs of interest, but not in controls. Five other ACACA SNPs, three additional NPY SNPs, and seven additional ACACB SNPs were not significant.
Department of Biostatistics, Kansas University Medical School, Kansas City, Kansas, United States.
Francisco J
FJ
Diaz
Alexander
A
Meary
Maria J
MJ
Arranz
Gualberto
G
Ruaño
Andreas
A
Windemuth
Jose
J
de Leon
D000103:Acetyl-CoA Carboxylase / Q000145:classification / Q000235:genetics*; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002784:Cholesterol / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000378:metabolism; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011618:Psychotic Disorders / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D017422:Sequence Analysis, DNA; D014280:Triglycerides / Q000378:metabolism*
D014150:Antipsychotic Agents; D009478:Neuropeptide Y; D014280:Triglycerides; D002784:Cholesterol; D000103:Acetyl-CoA Carboxylase