Pulmonary recruitment protocol for organ donors: a new strategy to improve the rate of lung utilization.
Because lung transplantation is the only effective therapy for terminal respiratory failure, the demand for donor lungs has increased steadily. However, the number of donors has remained fairly constant over the years, which results in an increasing duration of waiting for lung transplantation. To overcome the lack of organs, various strategies have been developed by transplant centers including use of marginal donors. To increase the lung utilization rate in multiorgan donors, we implemented a simple lung recruitment protocol involving a brief period of controlled sustained inflation. In 2005, the lung utilization rate in the transplant program at our institution was only 20% in multiorgan donors. With the lung recruitment protocol, the rate of lung utilization for transplantation increased to 33%, in 2006, 24% in 2007, and 24% in 2008. Following the lung recruitment protocol, the arterial oxygen tension/fraction of inspired oxygen ratio increased to greater than 15% in more than 40% of donors. We were able to improve gas exchange sufficiently that as many as two-thirds of the lungs were suitable for transplantation. During the protocol, no complications were reported, and no patient became hemodynamically unstable, precluding organ procurement. We believe that optimization of multiorgan donor management with simple interventions may improve oxygenation, reducing the number of inadequate donor lungs and increasing the overall donor pool and organ availability.
Noiseux
N
N
Division of Cardiac and Thoracic Surgery, Department of Surgery, Centre Hospitalier de l'Université de Montréal; Centre de Recherche CHUM, Montréal, Québec, Canada. noiseuxn@videotron.ca
Nguyen
B K
BK
Marsolais
P
P
Dupont
J
J
Simard
L
L
Houde
I
I
Lallier
M
M
Langevin
S
S
Cantin
B
B
Ferraro
P
P
D001926:Brain Death; D001999:Bronchoscopy; D002102:Cadaver; D006801:Humans; D016040:Lung Transplantation / Q000706:statistics & numerical data*; D008875:Middle Aged; D010101:Oxygen Consumption; D018579:Patient Selection; D011792:Quebec; D013902:Radiography, Thoracic; D012907:Smoking / Q000453:epidemiology; D014019:Tissue Donors / Q000706:statistics & numerical data*; D009927:Tissue and Organ Procurement / Q000379:methods / Q000706:statistics & numerical data; D014481:United States; D014850:Waiting Lists