Life style change and reverse cholesterol transport in obese women.
HDL cholesterol resp. apolipoprotein A1 concentrations are tools to estimate individual CVD risk, although only a part of HDL particles participate in reverse cholesterol transport (RCT). This discrepancy was analyzed in life style change based on increase of physical activity and dietary counseling. Efflux of cholesterol from pre-labeled macrophages to plasma acceptors of tested individuals was used as an RCT measure. Changes of lipoprotein parameters, glucose, fasting insulin concentrations and RCT were analyzed in 15 obese women after 9-week intervention consisted of 5 sessions of increased physical activity per week. Controlled increase in physical activity for 9 weeks induced a decrease of body weight averaging 9 kg (ranged from 2.3 to 15.5 kg). The intervention leads to significant decreases of triglycerides, apoprotein A1 and apoprotein B concentration, whereas total cholesterol, LDL cholesterol and HDL cholesterol did not change significantly. The increase of RCT was not significant, but there was highly significant negative correlation between individual decrease of body weight and an increase of RCT. Significant increase of RCT was found in 13 persons with a weight reduction more than 3.5 kg. Substantial weight loss is necessary to increase RCT.
Institute for Clinical and Experimental Medicine, Prague, Czech Republic. ivka@ikem.cz
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Králová Lesná
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Suchánek
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Poledne
D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D001692:Biological Transport; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D003131:Combined Modality Therapy; D003376:Counseling; D004032:Diet; D015444:Exercise; D005260:Female; D006801:Humans; D008264:Macrophages / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D040242:Risk Reduction Behavior; D013997:Time Factors; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D015431:Weight Loss
C505693:APOA1 protein, human; D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D015415:Biomarkers; D014280:Triglycerides; D002784:Cholesterol