Value of procalcitonin for diagnosis of early onset pneumonia in hypothermia-treated cardiac arrest patients.
OBJECTIVE
Early onset pneumonia is frequently reported after cardiac arrest, despite the fact that therapeutic hypothermia and post-resuscitation disease manifestations make it difficult to diagnose. We aimed to assess the ability of serum procalcitonin (PCT) measurements to help diagnose pneumonia in this setting.


METHODS
Retrospective study of consecutive patients admitted to a single academic medical intensive care unit (ICU) for successfully resuscitated cardiac arrest (July 2006-March 2008). All patient files were reviewed to assess the development of pneumonia during the first 5 days of ICU stay. Serum PCT was measured at admission, days (D) 1, 2 and 3.


RESULTS
Among 132 patients included, pneumonia was diagnosed in 86, and antibiotics were initiated in 115 patients during the first 5 days. PCT was significantly higher in patients with pneumonia at D1 (4.58 vs. 1.03 ng/ml, p = 0.017), D2 (3.76 vs. 0.73, p = 0.002) and D3 (3.76 vs. 0.73, p = 0.046). Areas under the ROC curves were 0.59 at admission, 0.64 at D1, 0.68 at D2 and 0.63 at D3. Using a threshold of 0.5 ng/ml, negative predictive values were 39% at admission, 42% at D1 and 52% at D2, whereas positive predictive values were 72, 68 and 70%, respectively. Patients with post-resuscitation shock (n = 66) had significantly higher PCT levels than vasopressor-free patients from D1 to D3.


CONCLUSIONS
The diagnostic value of PCT is poor after cardiac arrest and should not be performed to assess early onset pneumonia. The post-resuscitation disease itself could play a major role in this lack of specificity and predictive value.
Medical Intensive Care Unit, Cochin Hospital, AP-HP, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France. nmongardon@yahoo.fr
Nicolas
N
Mongardon
Virginie
V
Lemiale
Sébastien
S
Perbet
Florence
F
Dumas
Stéphane
S
Legriel
Sylvie
S
Guérin
Julien
J
Charpentier
Jean-Daniel
JD
Chiche
Jean-Paul
JP
Mira
Alain
A
Cariou
D000368:Aged; D015415:Biomarkers; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D016887:Cardiopulmonary Resuscitation; D003937:Diagnosis, Differential; D005260:Female; D006323:Heart Arrest / Q000453:epidemiology / Q000628:therapy*; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D007362:Intensive Care Units / Q000706:statistics & numerical data; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D011498:Protein Precursors / Q000097:blood*; D012189:Retrospective Studies
D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide