Wharton's jelly stromal cells as potential delivery vehicles for cancer therapeutics.
There is now compelling evidence that stem cells can be used as gene therapy delivery cells. Stem cells isolated from the Wharton's jelly of the umbilical cord (termed Wharton's jelly stromal cells) can be harvested noninvasively in large numbers and have been shown to traffic to tumors but do not form tumors themselves. WJS cells have low immunogenicity and they have also been engineered to secrete a cytokine, shown to home locally into the tumors in mice and with subsequent tumor attenuation. Naive rat and human Wharton's jelly stromal cells that are not engineered to secrete an exogenous protein also exert a potent anticancer effect in preclinical models.
Department of Anatomy & Physiology, Kansas State University, 1600 Denison Avenue, Manhattan, KS 66506, USA.
Raja Shekar
RS
Rachakatla
Deryl
D
Troyer
D000818:Animals; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D055029:Inverted Repeat Sequences / Q000502:physiology*; D009369:Neoplasms / Q000628:therapy*; D017154:Stromal Cells / Q000166:cytology / Q000276:immunology / Q000637:transplantation*; D014470:Umbilical Cord / Q000166:cytology*