Diversity synthesis of N-substituted 2-amino-1,6-naphthyridine derivatives under microwave irradiation.
A sequential three-component reaction of 3,5-diarylidenepiperidin-4-one, malononitrile, and amine (such as aromatic amine, cyclopropanamine, and NH(4)OAc) in acetic acid under microwave irradiation has been developed. In this one-pot reaction, a series of new N-substituted 2-amino-1,6-naphthyridine derivatives were synthesized with excellent yields. This method has the advantages of operational simplicity and increased safety for small-scale fast synthesis of N-aryl 2-amino-1,6-naphthyridines for biomedical screening.
School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu, PR China.
Zheng-Guo
ZG
Han
Chun-Bao
CB
Miao
Feng
F
Shi
Ning
N
Ma
Ge
G
Zhang
Shu-Jiang
SJ
Tu
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D008872:Microwaves; D009287:Naphthyridines / Q000138:chemical synthesis*; D011827:Radiation
D009287:Naphthyridines