Precursors of endometrial and ovarian carcinoma.
This review discusses precursor lesions of endometrial and ovarian carcinoma with an emphasis on the unique molecular alterations that have led to the development of binary classification schemes for tumors of both the endometrium and ovary. While such a system is well established for endometrial carcinoma, only recently has a binary classification scheme been proposed for ovarian carcinoma. For both, the morphologic and molecular genetic-defining characteristics of their respective precursor lesions are described in detail. Furthermore, similarities and differences of the precursor lesions of specific tumors of these two genital tract organs are also addressed with a brief discussion of the clinical implications of their diagnosis.
Kurman
Robert J
RJ
Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine and Hospital, Baltimore, MD, USA. rkurman@jhmi.edu
McConnell
Thomas G
TG
D002288:Adenocarcinoma, Mucinous / Q000473:pathology; D018269:Carcinoma, Endometrioid / Q000473:pathology; D004714:Endometrial Hyperplasia / Q000473:pathology; D016889:Endometrial Neoplasms / Q000145:classification / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000145:classification / Q000473:pathology* / Q000648:ultrastructure; D011230:Precancerous Conditions / Q000145:classification / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D016159:Tumor Suppressor Protein p53