SLP-2 overexpression is associated with tumour distant metastasis and poor prognosis in pulmonary squamous cell carcinoma.
OBJECTIVE
To investigate the role of stomatin-like protein 2 (SLP-2), a novel cancer-related gene, in pulmonary squamous cell carcinoma (PSCC) and its implications.


METHODS
Immunohistochemical detection of SLP-2 was performed on 96 cases of PSCC with a tissue microarray.


RESULTS
SLP-2 was overexpressed in lung cancer compared with normal lung tissue (p <0.001). High-level SLP-2 expression was significantly correlated with distant metastasis (p = 0.025), decreased overall survival (p = 0.018) and disease-free survival (p = 0.017). SLP-2 overexpression was an independent prognostic factor in multivariate analysis using the Cox regression model (p <0.05).


CONCLUSIONS
SLP-2 overexpression is associated with tumour distant metastasis and poor prognosis in PSCC. SLP-2 could be regarded as a new significant prognostic biomarker for patients with PSCC.
Department of Thoracic Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China. changdongj@yahoo.com.cn
Dong
D
Chang
Kai
K
Ma
Min
M
Gong
Yong
Y
Cui
Zhi-hua
ZH
Liu
Xiao-ge
XG
Zhou
Chuan-nong
CN
Zhou
Tian-you
TY
Wang
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D001798:Blood Proteins / Q000096:biosynthesis* / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D011379:Prognosis
D014408:Biomarkers, Tumor; D001798:Blood Proteins; D008565:Membrane Proteins; C406287:STOML2 protein, human