Physicochemical characterization and in vitro dissolution behaviour of celecoxib-beta-cyclodextrin inclusion complexes.
In this study, attempts were made to investigate the effects of beta-cyclodextrin (beta-CD) on the aqueous solubility and dissolution rate of celecoxib. Inclusion complexes were prepared by the kneading method and characterized by SEM, NMR, IR, DSC, and X-ray powder diffraction. Dissolution rate of the complexes was significantly greater than that of the corresponding physical mixtures and pure drug, indicating that the formation of inclusion complex increased the solubility of the poorly soluble drug celecoxib.
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. vr_sinha@yahoo.com
Vivek Ranjan
VR
Sinha
R
R
Anitha
Soma
S
Ghosh
Amita
Rachana
R
Kumria
Jayant Rajaram
JR
Bhinge
Manoj
M
Kumar
D002152:Calorimetry, Differential Scanning; D000068579:Celecoxib; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D011720:Pyrazoles / Q000737:chemistry*; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013449:Sulfonamides / Q000737:chemistry*; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins
D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D047392:beta-Cyclodextrins; D000068579:Celecoxib