Two patients with eating disorders treated by naltrexone.
According to a recent literature review on the opioid mechanism in eating disorders, we found that there is increasing reason to re-examine the treatment potential of naltrexone. The endogenous opioid system belongs to the important modulators of food intake. The eating disorders share many traits with substance dependence models. We present two case histories of time-limited naltrexone therapy to show that, in clinical practice, individualized indication may contribute to short-term improvement and to prediction of a different long-term treatment outcome.
Department of Psychiatry, Eating Disorders Unit, Charles University in Prague, First Faculty of Medicine, General Teaching Hospital, Prague, Czech Republic. vladimir.kmoch@centrum.cz
Vladimir
V
Kmoch
Hana
H
Papezova
Anna
A
Yamamotova
D000328:Adult; D000339:Affect / Q000187:drug effects*; D000437:Alcoholism / Q000150:complications / Q000188:drug therapy; D001068:Feeding and Eating Disorders / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D009271:Naltrexone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use; D012647:Self-Assessment
D009292:Narcotic Antagonists; D009271:Naltrexone