Reproductive development and function of female rats exposed to di-eta-butyl-phthalate (DBP) in utero and during lactation.
Phthalates are environmental contaminants used in the production of plastics, cosmetics and medical devices. Studies on the effects of phthalates on female reproductive health are particularly sparse and mostly restricted to high-dose exposure in rats. In the present study, pregnant rats were treated with 100mg/kg-d of di-eta-butyl-phthalate (DBP) or only the vehicle (control group), from GD 12 to GD 20 for evaluation of reproductive outcomes and fetal gonads analysis (F0), and from GD 12 to PND 21 to evaluate reproductive development and function on F1 female offspring. Results showed that all parameters were comparable between groups, although there was a significant increase in the fetal weight after DBP exposure. However, the body weight at birth was normal. Based on these data we can conclude that, in these experimental conditions, DBP did not disturb the reproductive development or function of female rats.
Department of Morphology, Institute of Biosciences, São Paulo State University, UNESP - Botucatu, São Paulo, CEP 18618-000,Brazil.
Marina T
MT
Guerra
Wellerson R
WR
Scarano
Fabíola C
FC
de Toledo
Janete A A
JA
Franci
Wilma De G
Wde G
Kempinas
D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D003993:Dibutyl Phthalate / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D005298:Fertility / Q000187:drug effects; D020567:Fetal Weight / Q000187:drug effects; D007774:Lactation; D008297:Male; D010053:Ovary / Q000187:drug effects / Q000196:embryology; D010968:Plasticizers / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects* / Q000502:physiology*; D012741:Sexual Maturation / Q000187:drug effects
D010968:Plasticizers; D003993:Dibutyl Phthalate