The influence of 1800 MHz GSM-like signals on hepatic oxidative DNA and lipid damage in nonpregnant, pregnant, and newly born rabbits.
The aim of our study is to evaluate the possible biological effects of whole-body 1800 MHz GSM-like radiofrequency (RF) radiation exposure on liver oxidative DNA damage and lipid peroxidation levels in nonpregnant, pregnant New Zealand White rabbits, and in their newly borns. Eighteen nonpregnant and pregnant rabbits were used and randomly divided into four groups which were composed of nine rabbits: (i) Group I (nonpregnant control), (ii) Group II (nonpregnant-RF exposed), (iii) Group III (pregnant control), (iv) Group IV (pregnant-RF exposed). Newborns of the pregnant rabbits were also divided into two groups: (v) Group V (newborns of Group III) and (vi) Group VI (newborns of Group III). 1800 MHz GSM-like RF radiation whole-body exposure (15 min/day for a week) was applied to Group II and Group IV. No significant differences were found in liver 8 OHdG/10(6) dG levels of exposure groups (Group II and Group IV) compared to controls (Group I and Group III). However, in Group II and Group IV malondialdehyde (MDA) and ferrous oxidation in xylenol orange (FOX) levels were increased compared to Group I (P < 0.05, Mann-Whitney). No significant differences were found in liver tissue of 8 OHdG/10(6) dG and MDA levels between Group VI and Group V (P > 0.05, Mann-Whitney) while liver FOX levels were found significantly increased in Group VI with respect to Group V (P < 0.05, Mann-Whitney). Consequently, the whole-body 1800 MHz GSM-like RF radiation exposure may lead to oxidative destruction as being indicators of subsequent reactions that occur to form oxygen toxicity in tissues.
Department of Biophysics, Gazi University, Faculty of Medicine, Gazi Universitesi Tip Fakültesi Biyofizik Abd, Dekanlik Binasi 5. Kat, 06500, Besevler, Ankara, Turkey. arintomruk@gmail.com
Arin
A
Tomruk
Goknur
G
Guler
Aylin Sepici
AS
Dincel
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D000831:Animals, Newborn; D040421:Cell Phone; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000378:metabolism; D005260:Female; D005296:Ferrous Compounds / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D050356:Lipid Metabolism / Q000528:radiation effects*; D015227:Lipid Peroxidation / Q000528:radiation effects; D008099:Liver / Q000378:metabolism* / Q000473:pathology / Q000528:radiation effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000528:radiation effects*; D011247:Pregnancy; D011817:Rabbits; D011846:Radio Waves / Q000009:adverse effects*
D005296:Ferrous Compounds; D005609:Free Radicals; D008315:Malondialdehyde; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine