Interleukin-1 beta single-nucleotide polymorphism's C allele is associated with elevated risk of gastric cancer in Helicobacter pylori-infected Peruvians.
Particular alleles of the interleukin-1B (IL-1B) gene have been correlated with increased risk of atrophic gastritis and gastric cancer in the populations of East Asia and Europe. No such data exist from Peru, a developing country with a population genotypically different from others studied and with a high prevalence of Helicobacter pylori infection and gastric cancer. We conducted a case-control study comparing 334 hospitalized patients with atrophic gastritis or gastric cancer with 158 nonatrophic gastritis patients (controls). Conditional logistic regression analysis revealed that an increased risk of atrophic gastritis (odds ratio, 5.60) and gastric cancer (odds ratio, 2.36) was associated with the IL-1B-511 C allele. Our study is the first to establish this allele as a risk for these conditions. Given the high prevalence of H. pylori and recurrence rate after treatment, IL-1B-511 single-nucleotide polymorphism analysis may identify those individuals who would benefit most from robust H. pylori eradication efforts in Peru.
Gehmert
Sebastian
S
Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, 77054, USA. s.gehmert@gmail.com
Velapatiño
Billie
B
Herrera
Phabiola
P
Balqui
Jaqueline
J
Santivañez
Livia
L
Cok
Jaime
J
Vargas
Gloria
G
Combe
Juan
J
Passaro
Douglas J
DJ
Wen
Sijin
S
Meyer
Frank
F
Berg
Douglas E
DE
Gilman
Robert H
RH
D000368:Aged; D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010568:Peru / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000150:complications / Q000235:genetics*
D053583:Interleukin-1beta