Rheumatoid arthritis in patient with homozygous haemoglobin C disease.
To date, few cases of hemoglobinopathies in patients with rheumatoid arthritis (RA) have been reported (Marino and Mcdonald in J Rheumatol 17:970-972, 1990; Gladman and Bombardier in Arthritis Rheum 30:1065-1068, 1987; Michel et al. in Semin Arthritis Rheum 38:228-240, 2008). These haemoglobin diseases are associated with characteristics abnormalities of the skeleton. Haemoglobin C disease is a benign hemoglobinopathy rarely associated with skeletal disorders [Piéron et al. in la semaine des hôpitaux 57(1-2):22-25, 1981]. We report a case of RA in a 60-year-old woman with homozygous haemoglobin C disease. This coexistence may be a pure coincidence, although we discuss the difficulties with RA treatment in this case due to the unknown effect of anti-rheumatic drugs on the progression of haemoglobin C disease.
Ali Ou Alla
Sanae
S
Department of Rheumatology, El Ayachi University Hospital, Sale, Morocco. sanae.alioualla@yahoo.fr
Allali
Fadoua
F
Hajjaj-Hassouni
Najia
N
D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006445:Hemoglobin C Disease / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D006720:Homozygote; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000175:diagnosis; D011241:Prednisone / Q000627:therapeutic use; D012074:Remission Induction
D018501:Antirheumatic Agents; D005938:Glucocorticoids; D011241:Prednisone; D008727:Methotrexate