Antiobesity action of a daidzein derivative on male obese mice induced by a high-fat diet.
Emerging evidence suggests that consumption or supplementation of foods rich in iso flavones may has a beneficial effect on obesity and glucose levels in animals and humans. It has been demonstrated that genistein, the main component of iso fl avones, could significantly reduce body weight and fat pad size. However, there is no evidence as to whether daidzein, which is also a main component of isoflavones, has the same effect. We hypothesize that LRXH609 (Dzd; a daidzein derivative) also has an antiobesity effect. In this study, we investigate the effects of Dzd on body weight, adipose tissue, blood, and liver lipid levels in obese mice fed a high-fat diet. Activities of pancreatic lipase and lipoprotein lipase, as well as lipolysis, were verified to clarify the potential mechanism of the daidzein. The results indicate that Dzd can significantly reduce body and fat pad weight and ameliorate the high-fat diet-induced hyperlipoidemia. We also found that Dzd inhibits the activity of pancreatic lipase and lipoprotein lipase in a dose-dependent manner, inhibits the differentiation of rat preadipocytes, and stimulates lipolysis by activating hormone-sensitive lipase.
Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, PR China.
Yongqi
Y
Guo
Guanzhong
G
Wu
Xin
X
Su
Hongxia
H
Yang
Juan
J
Zhang
D017667:Adipocytes / Q000187:drug effects; D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D006949:Hyperlipidemias / Q000188:drug therapy / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007529:Isoflavones / Q000494:pharmacology / Q000627:therapeutic use*; D008066:Lipolysis / Q000187:drug effects*; D008071:Lipoprotein Lipase / Q000037:antagonists & inhibitors; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008820:Mice, Obese; D009765:Obesity / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000201:enzymology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004041:Dietary Fats; D000960:Hypolipidemic Agents; D007529:Isoflavones; D010936:Plant Extracts; C004742:daidzein; D008071:Lipoprotein Lipase