Adiponectin, IL-10 and metabolic syndrome in obese children and adolescents.
The metabolic syndrome (MetS) is a common basis for the development of atherogenic cardiovascular disease. Adiponectin has been demonstrated to be insulin-sensitizing and an anti-atherogenic factor and is considered a key ofMetS. It was suggested that IL-10 may be involved in the inflammatory network of MetS in relation to adiponectin. We examined the relationship between adiponectin, IL-10 and MetS in pediatric obese patients. MetS components were assessed in 70 severely obese and 30 non-obese children and adolescents. Serum levels of adiponectin and IL-10 were measured in these subjects. Serum adiponectin levels were significantly lower (p < 0.001) and levels of IL-10 were significantly higher (p = 0.012) in obese subjects. MetS was present in 35.71% of obese patients. Patients with MetS showed a borderline significant decrease in serum adiponectin levels and significantly increased IL-10 levels when compared to those without MetS (p = 0.051 and p = 0.031, respectively); the differences in adiponectin and IL-10 values were controlled to the effect of BMI. No correlation between adiponectin and IL-10 levels was found. Our obese children showed hypoadiponectin and hyper-IL10 values. MetS was not associated with low IL-10. We probably observe a first phase of the complex mechanism implicated in the development of the MetS in children.
Department of Pediatrics, Found. IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy. v.calcaterra@smatteo.pv.it
Valeria
V
Calcaterra
Mara
M
De Amici
Catherine
C
Klersy
Cristina
C
Torre
Vincenza
V
Brizzi
Francesca
F
Scaglia
Michela
M
Albanesi
Riccardo
R
Albertini
Benedetta
B
Allais
Daniela
D
Larizza
D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D015994:Incidence; D016753:Interleukin-10 / Q000097:blood*; D007558:Italy / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000453:epidemiology
D052242:Adiponectin; D016753:Interleukin-10