Alterations in anterior chamber depth in primary open-angle glaucoma patients during latanoprost therapy.
OBJECTIVE
The aim of this study was to evaluate changes in the anterior chamber depth (ACD) in primary open-angle glaucoma (POAG) patients during latanoprost therapy.


METHODS
We carried out a prospective study in which we enrolled 66 newly diagnosed POAG patients treated with latanoprost 0.005% (group 1) and 50 ocular hypertensive and ⁄ or glaucoma suspect cases who were given no therapy (group 2 [control]). Measurements of the ACD were performed by A-scan ultrasonography before and after cycloplegia at baseline and at 3 months of latanoprost therapy. Differences in ACD and their correlations with the ocular hypotensive effect of the agent as well as the clinical significance of changes in ACD were analysed using Student’s t-test and Pearson’s correlation coefficient. Statistical significance was set at p < 0.05.


RESULTS
Mean baseline ACD was 3.13 ± 0.35 mm (range 2.45–3.84 mm) in group 1 and 3.14 ± 0.36 mm (range 2.54–3.80 mm) in group 2 (p = 0.89). At 1 hour after instillation of cyclopentolate 1%, mean ACD in groups 1 and 2 was 3.18 ± 0.38 mm (range 2.45–3.92 mm) and 3.19 ± 0.37 mm (range 2.56–3.91 mm), respectively (p = 0.91). After 3 months of treatment, mean ACD in group 1 both without (3.05 ± 0.36 mm, range 2.14–3.76 mm) and with (3.09 ± 0.4 mm, range 2.20–3.96 mm) cycloplegia was significantly reduced compared with baseline values (p < 0.001 for both). However, there was no significant difference between mean ACD at baseline and that at month 3 in group 2. No correlation was demonstrated between the changes in ACD and the ocular hypotensive effect of latanoprost (p = 0.96, r = – 0.006). There were no changes in refractive status or visual acuity.


CONCLUSIONS
The overall results seem to suggest that latanoprost decreases mean ACD in patients with POAG. The clinical significance of this effect is uncertain.
Cankaya
Ali Bulent
AB
Second Eye Clinic, Ulucanlar Eye Research Hospital, Ankara, Turkey. abcankaya@hotmail.com
Teberik
Pinar
P
Acaroglu
Golge
G
D000328:Adult; D000368:Aged; D000867:Anterior Chamber / Q000000981:diagnostic imaging / Q000187:drug effects*; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D011446:Prospective Studies; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage*; D012029:Refraction, Ocular / Q000502:physiology; D014463:Ultrasonography; D014792:Visual Acuity / Q000502:physiology
D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost