Analysis of human T-cell lymphotropic virus in CD25+ anaplastic large cell lymphoma in children.
Anaplastic large cell lymphoma (ALCL) is recognized as 2 distinct diseases: anaplastic lymphoma kinase (ALK)+ ALCL and ALK- ALCL. ALK+ ALCL occurs in younger patients and has a better prognosis. Human T-cell lymphotropic virus (HTLV-1) is linked to the development of adult T-cell leukemia/lymphoma (ATLL), which frequently expresses CD25. CD25 is significantly expressed in childhood ALCL. In Brazil, HTLV-1 infection is endemic, and vertical transmission is responsible for spread to children. Of HTLV-1 carriers, 90% or more remain asymptomatic. Some cases of adult HTLV-1-related lymphomas have characteristics of ALCL but are considered CD30+ ATLL subtypes. No similar cases have been described in children. We analyzed 33 cases of pediatric ALCL, CD25+ and CD25-, for proviral HTLV-1 DNA. All cases corresponded to the common histologic ALCL type and were CD30+ in virtually all neoplastic cells. ALK expression was observed in 31 (94%) of 33 cases; CD25 was positive in 27 (82%), including 1 ALK- ALCL case. There was a strong positive correlation between ALK and CD25 expression. None of the cases showed proviral HTLV-1 DNA. ALCL in children has no relationship with HTLV-1; the frequent CD25 expression must be explained by a mechanism different from that in ATLL.
Gualco
Gabriela
G
Consultoria em Patologia, Rua Major Leônidas Cardoso 739, Botucatu, SP, Brazil.
Chioato
Lucimara
L
Weiss
Lawrence M
LM
Harrington
William J
WJ
Bacchi
Carlos E
CE
D000077548:Anaplastic Lymphoma Kinase; D002467:Cell Nucleus / Q000201:enzymology / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002889:Chromosomes, Human, Pair 2; D002895:Chromosomes, Human, Pair 5; D003593:Cytoplasm / Q000201:enzymology / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015490:HTLV-I Infections / Q000150:complications* / Q000235:genetics / Q000473:pathology; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000032:analysis*; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000235:genetics / Q000473:pathology / Q000821:virology*; D008297:Male; D009367:Neoplasm Staging; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases; D014178:Translocation, Genetic
D004279:DNA, Viral; C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases