Poor clinical sensitivity of rapid antigen test for influenza A pandemic (H1N1) 2009 virus.
Influenza A pandemic (H1N1) 2009 virus RNA was detected by reverse transcription-PCR in 144 clinical samples from Bonn, Germany. A common rapid antigen-based test detected the virus in only 11.1% of these samples. The paramount feature of rapid test-positive samples was high virus concentration. Antigen-based rapid tests appear unsuitable for virologic diagnostics in the current pandemic.
Institute of Virology, Bonn, Germany.
Jan Felix
JF
Drexler
Angelika
A
Helmer
Heike
H
Kirberg
Ulrike
U
Reber
Marcus
M
Panning
Marcel
M
Müller
Katja
K
Höfling
Bertfried
B
Matz
Christian
C
Drosten
Anna Maria
AM
Eis-Hübinger
D000293:Adolescent; D000328:Adult; D000956:Antigens, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005188:False Negative Reactions; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000097:blood / Q000175:diagnosis*; D016133:Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D012698:Serologic Tests; D055815:Young Adult
D000956:Antigens, Viral