Further Daphniphyllum alkaloids with insecticidal activity from the bark of Daphniphyllum macropodum M(IQ).
Two new Daphniphyllum alkaloids, macropodumines J and K (1 and 2, resp.), together with six known structurally related alkaloids, 3-8, were isolated from the bark of Daphniphyllum macropodum M(IQ). The structures of the new compounds 1 and 2 were elucidated on the basis of a comprehensive analysis of their spectroscopic and chemical data. Macropodumine J (1) contains a CN group which is relatively rare in naturally occurring alkaloids. All isolated compounds were tested for their insecticidal activities against a number of insect species. Daphtenidine C (5) is the most active compound against Plutella xylostella. This is the first report of insecticidal properties of Daphniphyllum alkaloids.
Li
Zhen-Yu
ZY
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, PR China.
Gu
Yu-Cheng
YC
Irwin
Dianne
D
Sheridan
Jacqueline
J
Clough
John
J
Chen
Ping
P
Peng
Shu-Ying
SY
Yang
Yi-Ming
YM
Guo
Yue-Wei
YW
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002845:Chromatography; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007915:Lepidoptera / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D031995:Saxifragaceae / Q000737:chemistry*; D013057:Spectrum Analysis
D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D007306:Insecticides; D010936:Plant Extracts