Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
Five new steroids, norselic acids A-E (1-5), were isolated from the sponge Crella sp. collected in Antarctica. The planar structures of the norselic acids were established by extensive NMR spectroscopy and mass spectrometry studies, and the configuration of norselic acid A (1) was elucidated by X-ray crystallography. Norselic acid A displays antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA), methicillin-sensitive S. aureus (MSSA), vancomycin-resistant Enterococcus faecium (VRE), and Candida albicans and reduces consumption of food pellets by sympatric mesograzers. Compounds 1-5 are also active against the Leishmania parasite at low micromolar levels.
Ma
Wai S
WS
Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA.
Mutka
Tina
T
Vesley
Brian
B
Amsler
Margaret O
MO
McClintock
James B
JB
Amsler
Charles D
CD
Perman
Jason A
JA
Singh
Maya P
MP
Maiese
William M
WM
Zaworotko
Michael J
MJ
Kyle
Dennis E
DE
Baker
Bill J
BJ
D000818:Animals; D000864:Antarctic Regions; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D016984:Enterococcus faecium / Q000187:drug effects; D007891:Leishmania / Q000187:drug effects; D016106:Methicillin Resistance / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013203:Staphylococcal Infections / Q000188:drug therapy; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020713:Vancomycin Resistance / Q000187:drug effects
D000890:Anti-Infective Agents; D013256:Steroids