Mechanisms of HTLV-1 persistence and transformation.
Adult T-cell leukaemia (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1). HTLV-1 has elaborated strategies to persist and replicate in the presence of a strong immune response. In this review, we summarise these mechanisms and their contribution to T-cell transformation and ATL development.
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National Fund for Scientific Research, Gembloux Agro-Bio Tech, Molecular and Cellular Biology, Gembloux, Belgium.
Willems
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D050976:Basic-Leucine Zipper Transcription Factors / Q000502:physiology; D002472:Cell Transformation, Viral; D004249:DNA Damage; D016370:Gene Products, rex / Q000502:physiology; D016356:Gene Products, tax / Q000502:physiology; D042822:Genomic Instability; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000473:pathology / Q000821:virology; D012191:Retroviridae Proteins; D013601:T-Lymphocytes / Q000473:pathology*; D014764:Viral Proteins / Q000502:physiology; D014779:Virus Replication
D050976:Basic-Leucine Zipper Transcription Factors; D016370:Gene Products, rex; D016356:Gene Products, tax; C479751:HBZ protein, human T-cell leukemia virus type I; D012191:Retroviridae Proteins; D014764:Viral Proteins; C514844:rex Protein, Human T-lymphotropic virus 1; C514970:tax protein, Human T-lymphotrophic virus 1