Stem cells and the liver: clinical applications in transplantation.
ESLD affects millions of Americans, and HCV is a worldwide pandemic. Unfortunately, the ability to study liver disease and novel therapeutics experimentally in the laboratory is limited by an ongoing lack of small animal models. The development of rodents with livers chimeric for human hepatocytes may improve this situation. The authors' efforts currently use an immunodeficient or exogenously immunosuppressed animal with subsequent liver injury provided by chemical or surgical means. Cell transplantation with either human hepatocytes or human stem cells results in engraftment and subsequent "humanization" of an animal liver. Study of these animal models may lead to innovative approaches to the management of ESLD in both children and adults.
Locke
Jayme E
JE
Division of Transplantation, Department of Surgery, Johns Hopkins Medical Institutions, 720 Rutland Avenue, Ross Research Building, Room 765, Baltimore, MD 21205, USA.
Shamblott
Michael J
MJ
Cameron
Andrew M
AM
D000818:Animals; D006801:Humans; D017093:Liver Failure / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D033581:Stem Cell Transplantation / Q000379:methods*; D016896:Treatment Outcome