Dissolution of celecoxib from mucoadhesive disks based on polyaspartamide derivatives.
A series of mucoadhesive disks with celecoxib as a model drug of very low aqueous solubility were prepared and characterized. Two polymers of polyaspartamide type, poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)] (PHEA, 1) and its thiolated analogue poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)]-poly[alpha,beta-(N-2-thioethyl-DL-aspartamide)] copolymer (PHTA, 2a,b), and two commercially available polymers Carbopol 934P and hydroxypropylmethyl cellulose 4000 were used as excipients. Disks containing a mixture of equivalent amounts of thiomer 2b and Carbopol 934P as an excipient exhibited the highest dissolution rate.
Krznar
Davorka Ballian
DB
PLIVA - Research and Development, 10000 Zagreb, Croatia.
Filipović-Grcić
Jelena
J
Zorc
Branka
B
Zovko
Marijana
M
D000269:Adhesives; D000068579:Celecoxib; D002850:Chromatography, Gel; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry*; D007202:Indicators and Reagents; D007700:Kinetics; D008970:Molecular Weight; D010455:Peptides / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013449:Sulfonamides / Q000737:chemistry*
D000269:Adhesives; D052246:Cyclooxygenase 2 Inhibitors; D007202:Indicators and Reagents; D010455:Peptides; D011720:Pyrazoles; D013449:Sulfonamides; C008965:alpha,beta-poly((2-hydroxyethyl)-aspartamide); C545024:poly(alpha,beta-(N-2-hydroxyethyl-DL-aspartamide))-poly(alpha,beta-(N-2-thioethyl-DL-aspartamide)) copolymer; D000068579:Celecoxib