Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists.
The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.
EaStCHEM and School of Chemistry, Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK.
Michael P
MP
Van Ryssen
Nicolaos
N
Avlonitis
Rashid
R
Giniatullin
Craig
C
McDougall
James L
JL
Carr
Megan N
MN
Stanton-Humphreys
Emma L A
EL
Borgström
C Tom A
CT
Brown
Dmitriy
D
Fayuk
Alexander
A
Surin
Minna
M
Niittykoski
Leonard
L
Khiroug
Stuart J
SJ
Conway
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002211:Capsaicin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D054879:Halogenation / Q000187:drug effects; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D007834:Lasers; D008024:Ligands; D008027:Light; D008564:Membrane Potentials / Q000187:drug effects; D010782:Photolysis / Q000187:drug effects / Q000528:radiation effects*; D051381:Rats; D017208:Rats, Wistar; D050916:TRPV Cation Channels / Q000819:agonists* / Q000037:antagonists & inhibitors*; D014276:Trigeminal Nerve / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects
D008024:Ligands; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; D002211:Capsaicin; C040937:nonivamide; D002118:Calcium