From DNA to blood groups.
A blood group antigen is a protein or carbohydrate on the outer surface of a RBC. Portions of DNA are transcribed and translated into proteins. A protein-based blood group antigen is the direct product of a gene whereas a carbohydrate-based blood group antigen is an indirect product of a gene; the gene product is a glycosyltransferase that transfers a carbohydrate moiety to a protein, or to another carbohydrate to form a chain of sugars. This report gives a brief description of a gene, its processing from DNA through RNA to an amino acid sequence, and how changes in nucleotides give rise to blood group antigens.
New York Blood Center, New York, NY 10065, USA.
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D001789:Blood Group Antigens / Q000096:biosynthesis* / Q000235:genetics*; D002241:Carbohydrates / Q000096:biosynthesis / Q000235:genetics; D004247:DNA / Q000235:genetics; D005091:Exons / Q000235:genetics; D016695:Glycosyltransferases / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D016254:Mutagenesis, Insertional; D017384:Sequence Deletion
D001789:Blood Group Antigens; D002241:Carbohydrates; D004247:DNA; D016695:Glycosyltransferases