[Anal intraepithelial neoplasia (NIA) and infection with human papillomavirus (HPV) in anoreceptive patients].
BACKGROUND
An association between human papilloma virus (HPV) infection and progression to anal intraepithelial neoplasia (AIN) and epidermoid cancer has been established.


OBJECTIVE
To know the prevalence of low and high grade AIN, as well as HPV infection in an anoreceptive patients group, infected or not, by human immunodeficiency virus (HIV).


METHODS
All patients with anoreceptive sexual relations were considered in this study. Patients who accepted anal citology and high definition anoscopy and biopsies with a follow-up not minor of 3 months were included.


RESULTS
Forty-four patients were included: 40 male (90.9%) with average age of 31 years. Anal cytology showed inflammatory alterations in 21 patients (28%), low grade intraepithelial lesion in 23 (52%); there were not patients with high grade epithelial lesion. According to the high definition anoscopy, there were low grade intraepithelial lesion in 42 patients (95%) and high grade in 2 (5%). Biopsy showed low grade intraepithelial in 26 patients (59%), high grade in 4 (9%) and inflammatory alterations in 14 (32%). The prevalence of AIN and HPV infection was 68% in both diseases. The HIV infection was associated with the presence of high grade AIN (p=0.002, OR 47.7)


CONCLUSIONS
There is a high prevalence of AIN and HPV infection between patients with anoreceptive sexual relations. The HIV infection is a risk factor for the development of high grade AIN.
Charúa-Guindic
L
L
Unidad de Coloproctología del Servicio de Gastroenterología del Hospital General de México. luischarua@hotmail.com
Esquivel-Ocampo
E A
EA
Villanueva-Herrero
J A
JA
Jiménez-Bobadilla
B
B
Muñoz-Cortés
S B
SB
Leal-Tamez
M
M
Avendaño-Espinosa
O
O
D000293:Adolescent; D000328:Adult; D001003:Anal Canal / Q000473:pathology; D001005:Anus Neoplasms / Q000150:complications* / Q000473:pathology; D001706:Biopsy; D002278:Carcinoma in Situ / Q000150:complications* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications* / Q000473:pathology; D012307:Risk Factors; D012725:Sexual Behavior / Q000706:statistics & numerical data*; D055815:Young Adult