Subcortical vascular dementia biomarker pattern in mild cognitive impairment.
BACKGROUND
Mild cognitive impairment (MCI) is an etiologically unclear disorder. Cerebrospinal fluid (CSF) biomarkers are potentially useful for the differentiation between various MCI etiologies.


OBJECTIVE
The aim of the study was to assess whether baseline CSF hyperphosphorylated tau (P-tau), total tau (T-tau), amyloid beta 1-42 (Abeta(42)) and neurofilament light (NF-L) in patients with MCI could predict subcortical vascular dementia (SVD) and Alzheimer's disease (AD) at follow-up.


METHODS
Biomarker levels were assessed by Luminex xMAP technology and ELISA.


RESULTS
Increased baseline concentrations of NF-L significantly separated MCI-SVD from stable MCI. The MCI-SVD patients were inseparable from stable MCI but separable from patients developing AD (MCI-AD) on the basis of Abeta(42,) T-tau and P-tau(181) levels.


CONCLUSIONS
A combination of the biomarkers Abeta(42), T-tau, P-tau(181) and NF-L has the potential to improve the clinical separation of MCI-SVD patients from stable MCI and MCI-AD patients.
Bjerke
Maria
M
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden. maria.bjerke@neuro.gu.se
Andreasson
Ulf
U
Rolstad
Sindre
S
Nordlund
Arto
A
Lind
Karin
K
Zetterberg
Henrik
H
Edman
Ake
A
Blennow
Kaj
K
Wallin
Anders
A
D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D001057:Apolipoproteins E / Q000235:genetics; D015415:Biomarkers; D003072:Cognition Disorders / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D015140:Dementia, Vascular / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016900:Neurofilament Proteins / Q000134:cerebrospinal fluid; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D015899:Tomography, Emission-Computed, Single-Photon; D016875:tau Proteins / Q000134:cerebrospinal fluid
D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E; D015415:Biomarkers; D016900:Neurofilament Proteins; C044882:neurofilament protein L; D016875:tau Proteins