Synthesis, structure, electrochemistry and spectral characterization of (D-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich ascites carcinoma in Swiss albino mice.
The novel glycosyl saccharide derivative, (D-glucopyranose)-4-phenylthiosemicarbazide (LH) and its complexes, with cobalt(II), nickel(II), copper(II) and zinc(II) were synthesized, characterised and tested for cytotoxic effects. The copper complex, [CuLCl] inhibited Ehrlich Ascites Carcinoma (EAC) induced cancer cell lines in Swiss albino mice at LC50=1.94 x 10(-8) (LC50=2.76 x 10(-8) for cisplatin) and so distinctly better than free ligand and other complexes.
Sathisha
M P
MP
Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad 580 003, Karnataka, India.
Budagumpi
Srinivasa
S
Kulkarni
Naveen V
NV
Kurdekar
Gurunath S
GS
Revankar
V K
VK
Pai
K S R
KS
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D040761:Biomimetic Materials / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D004563:Electrochemistry; D005260:Female; D006031:Glycosylation; D008280:Magnetics; D051379:Mice; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D012439:Saccharin / Q000737:chemistry; D012663:Semicarbazides / Q000737:chemistry*; D013057:Spectrum Analysis; D013696:Temperature
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D012663:Semicarbazides; C005151:thiosemicarbazide; D002244:Carbon; D012439:Saccharin