Synthesis and biological evaluation of pyridinebetaine A and B.
The synthesis of the marine natural products pyridinebetaine A and B is reported. The biological evaluation of pyridinebetaine A and B and several analogues as cytotoxic, antifungal and antiviral agents is also described. Unfortunately, none of the compounds tested showed relevant antifungal or cytotoxic activity. Only pyridinebetaine B reduced the Herpes simplex virus type 1 virus replication, though only weakly.
González
Miguel A
MA
Departamento de Química Orgánica, Universidad de Valencia, Valencia, Spain. miguel.a.gonzalez@uv.es
Correa-Royero
Julieth
J
Mesa
Ana
A
Betancur-Galvis
Liliana
L
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001622:Betaine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D005658:Fungi / Q000187:drug effects; D006367:HeLa Cells; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
D000470:Alkaloids; D000935:Antifungal Agents; D000998:Antiviral Agents; D001622:Betaine