The predicted protein structures of the novel DRB1*0717 and DRB1*0701 are highly related.
This article describes the identification of the novel human leukocyte antigen (HLA) allele DRB1*07 7 that was detected in a potential stem-cell donor of Caucasian origin. Compared to DRB1*070101, the new allele is characterized by a nonsynonymous nucleotide exchange of C-->T at position 201 in exon 2 replacing Arg by Trp in codon 72. As this sequence variation has not been seen earlier in any other HLA-DRB allele, it is most probably the result of a point mutation.
Wurm
M
M
Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany.
Tischer
S
S
Immenschuh
S
S
Blasczyk
R
R
Eiz-Vesper
B
B
D000595:Amino Acid Sequence; D001483:Base Sequence; D019295:Computational Biology; D030562:Databases, Protein; D005544:Forecasting; D006684:HLA-DR Antigens / Q000737:chemistry* / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid; D040681:Structural Homology, Protein
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C456920:HLA-DRB1*07 antigen