[Humanized model for acute myeloid leukemia].
To investigate human hematopoiesis and immunity in vivo, we have been making efforts to reconstitute these systems in mice by intravenously injecting purified human stem cells into NOD/SCID/IL2rgKO newborns. This xenogeneic transplantation system supports long-term engraftment, multi-lineage differentiation, and self-renewal capacity of human cord blood-derived hematopoietic stem cells (HSCs). We here introduce our recent application of the NOD/SCID/IL2rgKO newborn xenotransplant system to create in vivo models for human hematological malignancies and to understand pathophysiology of human AML.
Research Unit for Human Disease Models, RIKEN Research Center for Allergy and Immunology.
Fumihiko
F
Ishikawa
D000818:Animals; D000831:Animals, Newborn; D036101:Cord Blood Stem Cell Transplantation; D004195:Disease Models, Animal; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D014411:Neoplastic Stem Cells; D014183:Transplantation, Heterologous