Swerilactones C and D, anti-HBV new lactones from a traditional Chinese herb: Swertia mileensis.
Swerilactones C (1) and D (2), two novel diastereomeric lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb Swertia mileensis. Their structures and relative stereochemistry were elucidated on the basis of spectroscopic methods and further confirmed by X-ray single-crystal diffraction analysis. In vitro antihepatitis B virus (HBV) assay on the Hep G 2.2.15 cell line showed that both compounds 1 and 2 exhibited inhibitory activities against the secretion of HBsAg (IC(50) = 1.24 and 2.96 mM, respectively) and HBeAg (IC(50) = 0.77 and 1.47 mM, respectively).
Geng
Chang-An
CA
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PRC.
Zhang
Xue-Mei
XM
Shen
Yong
Y
Zuo
Ai-Xue
AX
Liu
Ji-Feng
JF
Ma
Yun-Bao
YB
Luo
Jie
J
Zhou
Jun
J
Jiang
Zhi-yong
ZY
Chen
Ji-Jun
JJ
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018360:Crystallography, X-Ray; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure
D000998:Antiviral Agents; D007783:Lactones; C545604:swerilactone C; C545605:swerilactone D