miRGen 2.0: a database of microRNA genomic information and regulation.
MicroRNAs are small, non-protein coding RNA molecules known to regulate the expression of genes by binding to the 3'UTR region of mRNAs. MicroRNAs are produced from longer transcripts which can code for more than one mature miRNAs. miRGen 2.0 is a database that aims to provide comprehensive information about the position of human and mouse microRNA coding transcripts and their regulation by transcription factors, including a unique compilation of both predicted and experimentally supported data. Expression profiles of microRNAs in several tissues and cell lines, single nucleotide polymorphism locations, microRNA target prediction on protein coding genes and mapping of miRNA targets of co-regulated miRNAs on biological pathways are also integrated into the database and user interface. The miRGen database will be continuously maintained and freely available at http://www.microrna.gr/mirgen/.
Institute of Molecular Oncology, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece. pan.alexiou@fleming.gr
Panagiotis
P
Alexiou
Thanasis
T
Vergoulis
Martin
M
Gleditzsch
George
G
Prekas
Theodore
T
Dalamagas
Molly
M
Megraw
Ivo
I
Grosse
Timos
T
Sellis
Artemis G
AG
Hatzigeorgiou
D020413:3' Untranslated Regions; D000465:Algorithms; D000818:Animals; D045744:Cell Line, Tumor; D019295:Computational Biology / Q000379:methods* / Q000639:trends; D030541:Databases, Genetic; D030561:Databases, Nucleic Acid; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods; D020407:Internet; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012984:Software; D014157:Transcription Factors / Q000235:genetics*
D020413:3' Untranslated Regions; D035683:MicroRNAs; D014157:Transcription Factors