Two new peltogynoids from Acacia nilotica Delile with kinase inhibitory activity.
Two new peltogynoids, acanilol (1) and acanilol B (2), were isolated from the stem bark of Acacia nilotica (L.) Delile, together with the known triterpene lupenone. The structures of the new compounds were established on the basis of their spectral data, mainly UV, NMR, and mass spectrometry. The new compounds were tested as kinase inhibitors against CDK1, GSK3, CK1, and DYRK1A, and acanilol B was identified as a DYRK1A inhibitor, with an IC(50) of 19 microM.
Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens, Greece.
Augustine
A
Ahmadu
Agunu
A
Abdulkarim
Raphaël
R
Grougnet
Vassilios
V
Myrianthopoulos
François
F
Tillequin
Prokopios
P
Magiatis
Alexios-Leandros
AL
Skaltsounis
D000045:Acacia / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011494:Protein Kinases / Q000737:chemistry
D005419:Flavonoids; D010936:Plant Extracts; D047428:Protein Kinase Inhibitors; C549761:acanilol A; C549760:acanilol B; D011494:Protein Kinases