Glomerular disease: sugars and immune complex formation in IgA nephropathy.
In vitro evidence suggests that immune complex formation in IgA nephropathy is determined by the sugar content of the IgA1 hinge region. Absence of galactose residues in this region renders the IgA1 molecule immunogenic.
Jonathan
J
Barratt
Frank
F
Eitner
D000936:Antigen-Antibody Complex / Q000276:immunology*; D002241:Carbohydrates / Q000276:immunology*; D005922:Glomerulonephritis, IGA / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007678:Kidney Glomerulus / Q000276:immunology*
D000936:Antigen-Antibody Complex; D002241:Carbohydrates; D007070:Immunoglobulin A