[Transcatheter arterial chemoembolization with high-dose iodized oil for hepatic VX2 tumor in rabbits].
OBJECTIVE
To evaluate the effect of transcatheter arterial chemoembolization (TACE) with high-dose iodized oil on hepatic tumor growth and metastasis in rabbits.


METHODS
Forty-eight rabbits with implanted VX2 tumor were randomly divided into control group, routine dose iodized oil TACE group and high-dose iodized oil TACE group to receive perfusion through the hepatic artery with 0.9% saline, 5 mg adriamycin with routine-dose iodized oil, and 5 mg adriamycin with high-dose iodized oil, respectively. The tumor volume, tumor necrosis, intrahepatic and lung metastasis were examined 2 weeks after TACE.


RESULTS
No significant difference was found in the tumor volume between the 3 groups before TACE (P>0.05). The rabbits receiving TACE with iodized oil, especially at the high dose, showed significantly reduced tumor volume as compared with the control group (P<0.01). TACE with high-dose iodized oil resulted in significantly increased tumor necrosis rate in comparison with the control group and TACE with a routine dose of iodized oil (P<0.05); high-dose iodized oil TACE was also associated with reduced intrahepatic and lung metastasis as compared routine dose iodized oil TACE (P<0.05).


CONCLUSIONS
TACE with high-dose iodized oil can obviously inhibit the growth and intrahepatic and lung metastasis of transplanted VX2 liver tumor in rabbits .
Department of Gastroenterology, First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710061, China. Liangshan72@sohu.com
Liang-shan
LS
Lü
Qing-yong
QY
Ma
Ya-min
YM
Liu
D000818:Animals; D002406:Catheterization, Peripheral; D016461:Chemoembolization, Therapeutic / Q000379:methods; D003287:Contrast Media / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers / Q000008:administration & dosage; D005260:Female; D006499:Hepatic Artery; D007459:Iodized Oil / Q000008:administration & dosage*; D008114:Liver Neoplasms, Experimental / Q000628:therapy*; D008297:Male; D011817:Rabbits
D003287:Contrast Media; D004337:Drug Carriers; D007459:Iodized Oil