RANTES promoter genotype and gastric cancer risk in a Japanese population.
BACKGROUND
A complex interaction of genetic and environmental factors is relevant in gastric carcinogenesis. Previous studies reported that the expression of RANTES is enhanced in Helicobacter pylori-infected gastric mucosa. Elevated serum level of RANTES in gastric cancer patients was also reported. We aimed to clarify the effect of RANTES promoter polymorphism on the risk of gastric cancer (GC) in a Japanese population.


METHODS
A total of 191 GC and 335 non-cancer patients including H. pylori-positive gastritis (n=180) and H. pylori- negative healthy stomach (n=155) were genotyped for polymorphisms at -28 C/G in the RANTES gene promoter region.


RESULTS
RANTES promoter genotype distributions were not significantly different among GC, overall non-cancer patients, healthy stomach and gastritis. In the comparison of genotype frequency between GC and healthy stomach, only a weak correlation was found between -28G/G genotype and GC in individuals more than 70 years of age (odds ratio (OR)=7.65, 95% confidence interval (CI)=0.78-75.0, p=0.07), with advanced stage (OR=6.58, 95% CI=0.72-59.77, p=0.07), lymph node metastasis (OR=7.20, 95% CI=0.79-65.46, p=0.06) and peritoneal dissemination (OR=10.93, 95% CI=0.96-124.64, p=0.07).


CONCLUSIONS
The effect of -28 C/G polymorphism in the RANTES gene promoter on GC development may not to be very strong. The role of RANTES promoter polymorphism in gastric carcinogenesis needs further evaluation.
Department of Gastroenterology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan. tomomiccyu@yahoo.co.jp
Tomomitsu
T
Tahara
Tomoyuki
T
Shibata
Masakatsu
M
Nakamura
Hiromi
H
Yamashita
Daisuke
D
Yoshioka
Ichiro
I
Hirata
Tomiyasu
T
Arisawa
D018946:Chemokine CCL5 / Q000235:genetics*; D005260:Female; D005756:Gastritis / Q000150:complications / Q000382:microbiology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D016481:Helicobacter Infections / Q000150:complications / Q000235:genetics; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D013274:Stomach Neoplasms / Q000235:genetics* / Q000382:microbiology
C483024:CCL5 protein, human; D018946:Chemokine CCL5