Harnessing immune alterations in neurodegenerative diseases.
Immune dysfunction, a well-established feature of neuroinflammatory disease, is increasingly recognized in neurodegenerative conditions. Its role is emerging as an early and active participant in neuropathology. Inflammation could be modified, with disease-slowing effects, by targeted interventions; it is also readily detectable and could serve as a source of valuable biomarkers.
Björkqvist
Maria
M
Neuronal Survival Unit, Department of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, S-221 84 Lund, Sweden. maria.bjorkqvist@med.lu.se
Wild
Edward J
EJ
Tabrizi
Sarah J
SJ
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology* / Q000503:physiopathology*; D017628:Microglia / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology*; D015213:Neuroimmunomodulation / Q000502:physiology*; D013116:Spinal Cord / Q000276:immunology / Q000502:physiology
D015415:Biomarkers