Interleukin-1 beta single-nucleotide polymorphism's C allele is associated with elevated risk of gastric cancer in Helicobacter pylori-infected Peruvians.
Particular alleles of the interleukin-1B (IL-1B) gene have been correlated with increased risk of atrophic gastritis and gastric cancer in the populations of East Asia and Europe. No such data exist from Peru, a developing country with a population genotypically different from others studied and with a high prevalence of Helicobacter pylori infection and gastric cancer. We conducted a case-control study comparing 334 hospitalized patients with atrophic gastritis or gastric cancer with 158 nonatrophic gastritis patients (controls). Conditional logistic regression analysis revealed that an increased risk of atrophic gastritis (odds ratio, 5.60) and gastric cancer (odds ratio, 2.36) was associated with the IL-1B-511 C allele. Our study is the first to establish this allele as a risk for these conditions. Given the high prevalence of H. pylori and recurrence rate after treatment, IL-1B-511 single-nucleotide polymorphism analysis may identify those individuals who would benefit most from robust H. pylori eradication efforts in Peru.
Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, 77054, USA. s.gehmert@gmail.com
Sebastian
S
Gehmert
Billie
B
Velapatiño
Phabiola
P
Herrera
Jaqueline
J
Balqui
Livia
L
Santivañez
Jaime
J
Cok
Gloria
G
Vargas
Juan
J
Combe
Douglas J
DJ
Passaro
Sijin
S
Wen
Frank
F
Meyer
Douglas E
DE
Berg
Robert H
RH
Gilman
D000368:Aged; D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010568:Peru / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000150:complications / Q000235:genetics*
D053583:Interleukin-1beta