Heterocycles from cyclopropanes: applications in natural product synthesis.
The construction of heterocyclic compounds from activated cyclopropane derivatives offers an alternative strategy for the preparation of molecules that may be of interest from a structural or biological standpoint. Several newly developed methods provide access to densely functionalized heterocycles in a manner that can be considered useful for both diversity- and target-oriented synthetic approaches. This tutorial review focuses on the latter, describing recent developments and applications of cyclopropane ring-expansion reactions in natural product synthesis.
University of Western Ontario, Department of Chemistry, London, ON, N6A 5B7, Canada.
Cheryl A
CA
Carson
Michael A
MA
Kerr
D001688:Biological Products / Q000138:chemical synthesis*; D003500:Cyclization; D003521:Cyclopropanes / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*
D001688:Biological Products; D003521:Cyclopropanes; D006571:Heterocyclic Compounds