Mediators and receptors in the resolution of inflammation: drug targeting opportunities.
The active resolution of inflammation is recognized as offering new opportunities to generate novel anti-inflammatory agents. The emerging appreciation of the importance of active resolution in regulation of inflammation also creates an imperative to examine developing and existing agents for their potential to influence these pathways. This themed issue of the British Journal of Pharmacology contains papers that discuss the roles of annexin-1, lipoxins and related lipid products of fish oils as well as other mechanisms involved in active resolution and their receptor targets.
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D000818:Animals; D017305:Annexin A1 / Q000276:immunology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D016503:Drug Delivery Systems; D015525:Fatty Acids, Omega-3 / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D018836:Inflammation Mediators / Q000502:physiology*; D044045:Lipoxins / Q000502:physiology; D044463:Receptor, PAR-1 / Q000276:immunology*; D044042:Receptors, Formyl Peptide / Q000276:immunology*; D015398:Signal Transduction / Q000187:drug effects
D017305:Annexin A1; D000893:Anti-Inflammatory Agents; D015525:Fatty Acids, Omega-3; D018836:Inflammation Mediators; D044045:Lipoxins; D044463:Receptor, PAR-1; D044042:Receptors, Formyl Peptide