S100A8 and S100A9 expression is a crucial factor for dedifferentiation in thyroid carcinoma.
BACKGROUND
S100A8 plays a role in various functions of myeloid cells by forming a heterocomplex with S100A9. S100A8 and S100A9 are also known to be overexpressed in certain species of carcinomas.


METHODS
In this study, the protein expression of S100A8 as well as that of S100A9 was investigated in thyroid tumors.


RESULTS
All of the undifferentiated carcinomas were immunopositive for S100A8 and S100A9 and overlap between staining patterns of both proteins was observed. In poorly differentiated carcinomas, all the cases were negative for S100A8, while slight immunopositivity of S100A9 was seen in 2 cases. Papillary carcinoma, follicular carcinoma, follicular adenoma and medullary carcinoma and normal follicules were negative for both proteins.


CONCLUSIONS
S100A8 plays an important role in dedifferentiation of thyroid carcinoma possibly by forming a complex with S100A9.
Ito
Yasuhiro
Y
Department of Surgery, Kuma Hospital, 8-2-35, Shimoyamate-dori, Chuo-ku, Kobe 650-0011, Japan. ito01@kuma-h.or.jp
Arai
Kazumori
K
Nozawa
Ryushi
R
Yoshida
Hiroshi
H
Hirokawa
Mitsuyoshi
M
Fukushima
Mitsuhiro
M
Inoue
Hiroyuki
H
Tomoda
Chisato
C
Kihara
Minoru
M
Higashiyama
Takuya
T
Takamura
Yuuki
Y
Miya
Akihiro
A
Kobayashi
Kaoru
K
Matsuzuka
Fumio
F
Miyauchi
Akira
A
D040501:Calgranulin A / Q000096:biosynthesis*; D040502:Calgranulin B / Q000096:biosynthesis*; D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology
D040501:Calgranulin A; D040502:Calgranulin B