Adipocytokines in relation to Hodgkin lymphoma in children.
This case-control study aims to explore the association of serum adiponectin/leptin with childhood Hodgkin lymphoma (HL). Study participants were 75 children with histologically confirmed HL, registered in the Nationwide Registry for Childhood Haematological Malignancies and 75 age- and gender-matched controls. Multiple conditional logistic regression analyses were performed, adjusting for sociodemographic and lifestyle parameters. Adiponectin levels were consistently higher among cases in all models with ORs >1.25; 95% CIs ranging from 0.9 to 1.8 and P-values from 0.09 to 0.20. By contrast, there was no association of serum leptin with HL. In conclusion, elevated serum adiponectin might be a risk factor for childhood HL.
Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, Athens, Greece. epetrid@med.uoa.gr
Eleni Th
ET
Petridou
Nick
N
Dessypris
Paraskevi
P
Panagopoulou
Theodoros N
TN
Sergentanis
Alexios-Fotios A
AF
Mentis
Apostolos
A
Pourtsidis
Sophia
S
Polychronopoulou
Maria
M
Kalmanti
Fani
F
Athanasiadou-Piperopoulou
Maria
M
Moschovi
D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006115:Greece / Q000453:epidemiology; D006689:Hodgkin Disease / Q000097:blood* / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D020738:Leptin / Q000097:blood*; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D012307:Risk Factors
D052242:Adiponectin; D020738:Leptin