A follow-up study of mortality among women in the North American synthetic rubber industry.
OBJECTIVE
To evaluate mortality from cancer and other diseases among 4863 women employed at eight North American styrene-butadiene rubber plants. Cancers of the lymphohematopoietic tissues, breast, and ovary were of strongest a priori interest.


METHODS
Cause-specific standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) were estimated.


RESULTS
The observed number of deaths was approximately equal to that expected for leukemia (10 observed/13 expected), Hodgkin lymphoma (1/1.6), multiple myeloma (7/7.9), non-Hodgkin lymphoma (15/14), and cancers of the breast (72/74) and ovary (21/22). Ever-hourly women had more than expected deaths from lung (47/30, SMR = 159, CI = 117 to 211) and bladder (6/1.8, SMR = 332, CI = 122 to 723) cancers. Exposure-response analysis, done only for lung cancer, indicated no trend for butadiene or styrene.


CONCLUSIONS
The observed excesses of lung and bladder cancers may be attributable to nonoccupational factors rather than to workplace exposures.
Sathiakumar
Nalini
N
Department of Epidemiology, School of Public Health, The University of Alabama at Birmingham, Birmingham, Ala, USA. nalini@uab.edu
Delzell
Elizabeth
E
D000368:Aged; D000369:Aged, 80 and over; D002070:Butadienes / Q000008:administration & dosage / Q000009:adverse effects; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007221:Industry; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000401:mortality*; D009656:North America / Q000453:epidemiology; D016273:Occupational Exposure; D012189:Retrospective Studies; D012408:Rubber; D013343:Styrenes / Q000008:administration & dosage / Q000009:adverse effects
D002070:Butadienes; D013343:Styrenes; D012408:Rubber