Rossinones A and B, biologically active meroterpenoids from the Antarctic ascidian, Aplidium species.
Rossinones A (1) and B (2), biologically active meroterpene derivatives, were isolated from an Antarctic collection of the ascidian Aplidium species and structurally characterized with spectroscopic methods. The absolute configuration of 1 was deduced by using the modified Mosher method. The rossinones exhibit anti-inflammatory, antiviral and antiproliferative activities.
Appleton
David R
DR
Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
Chuen
Cheah Shiau
CS
Berridge
Michael V
MV
Webb
Victoria L
VL
Copp
Brent R
BR
D000818:Animals; D000864:Antarctic Regions; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014561:Urochordata / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D013729:Terpenes; C547432:rossinone A; C547433:rossinone B