Multicenter study of prevalence of nontuberculous mycobacteria in patients with cystic fibrosis in france.
We performed a multicenter prevalence study of nontuberculous mycobacteria (NTM) involving 1,582 patients (mean age, 18.9 years; male/female ratio, 1.06) with cystic fibrosis in France. The overall NTM prevalence (percentage of patients with at least one positive culture) was 6.6% (104/1,582 patients), with prevalences ranging from 3.7% (in the east of France) to 9.6% (in the greater Paris area). Mycobacterium abscessus complex (MABSC; 50 patients) and Mycobacterium avium complex (MAC; 23 patients) species were the most common NTM, and the only ones associated with fulfillment of the American Thoracic Society bacteriological criteria for NTM lung disease. The "new" species, Mycobacterium bolletii and Mycobacterium massiliense, accounted for 40% of MABSC isolates. MABSC species were isolated at all ages, with a prevalence peak between 11 and 15 years of age (5.8%), while MAC species reached their highest prevalence value among patients over 25 years of age (2.2%).
Roux
Anne-Laure
AL
EA3647, UFR de Médecine Paris Ile-de-France Ouest, Université de Versailles Saint Quentin en Yvelines, Guyancourt, France.
Catherinot
Emilie
E
Ripoll
Fabienne
F
Soismier
Nathalie
N
Macheras
Edouard
E
Ravilly
Sophie
S
Bellis
Gil
G
Vibet
Marie-Anne
MA
Le Roux
Evelyne
E
Lemonnier
Lydie
L
Gutierrez
Cristina
C
Vincent
Véronique
V
Fauroux
Brigitte
B
Rottman
Martin
M
Guillemot
Didier
D
Gaillard
Jean-Louis
JL
D000293:Adolescent; D000328:Adult; D002648:Child; D003550:Cystic Fibrosis / Q000453:epidemiology* / Q000382:microbiology*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008171:Lung Diseases / Q000150:complications / Q000453:epidemiology; D008297:Male; D009165:Mycobacterium Infections, Nontuberculous / Q000453:epidemiology* / Q000382:microbiology; D015269:Mycobacterium avium Complex / Q000145:classification / Q000302:isolation & purification*; D015270:Mycobacterium avium-intracellulare Infection / Q000453:epidemiology* / Q000382:microbiology; D009170:Nontuberculous Mycobacteria / Q000145:classification / Q000302:isolation & purification*; D015995:Prevalence; D055815:Young Adult