Testicular function after treatment for acute lymphoblastic leukemia (all) in prepubertal and pubertal boys.
Testicular function was evaluated in 59 male (27 prepubertal and 32 pubertal) survivors treated for ALL according to two different protocols. Serum inhibin B, FSH, testosterone, LH, and testicular volume were measured. In both groups the mean values of inhibin B were lower than control, whereas the other analyzed parameters were comparable. The inhibin B-to-FSH ratio was reduced as compared to the control. Testicular volume was lower than in healthy pubertal patients. The results show that treatment for ALL has a negative effect on spermatogenesis, regardless of the age at treatment and type of therapy.
Krawczuk-Rybak
Maryna
M
Department of Pediatric Oncology and Hematology, Medical University, Bialystok, Poland. rybak@muwb.edu.pl
Solarz
Elzbieta
E
Wysocka
Jolanta
J
Matysiak
Michal
M
Gadomski
Artur
A
Kazanowska
Bernarda
B
Sega-Pondel
Dorota
D
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D001215:Asparaginase / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D003630:Daunorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007265:Inhibins / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects; D012189:Retrospective Studies; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000254:growth & development / Q000378:metabolism* / Q000473:pathology; D013739:Testosterone / Q000097:blood*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
C422364:inhibin B; D013739:Testosterone; D007265:Inhibins; D014750:Vincristine; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D001215:Asparaginase; D011241:Prednisone; D003630:Daunorubicin