Reduced carriership of 4G allele of plasminogen activator inhibitor-1 4G/5G polymorphism in very young survivors of myocardial infarction.
There are limited and controversial data regarding the impact of 4G/5G polymorphism of the plasminogen activator inhibitor-1 (PAI-1) gene in the pathogenesis of premature myocardial infarction (MI). We explored whether 4G/5G polymorphism of the PAI-1 gene is associated with the development of MI <or= 35 years of age. We recruited 201 consecutive patients who had survived their first acute MI <or= 35 years of age (mean age = 32.2 +/- 3.4 years). The control group consisted of 140 healthy individuals matched with cases for age and sex, without a family history of premature coronary heart disease. 4G/5G polymorphism of PAI-1 was tested with polymerase chain reaction and reverse hybridization. 4G allele carriers (4G/4G and 4G/5G genotypes) of PAI-1 were less frequent in patients than in controls (69.6 vs. 83.6%, P = 0.007). 4G carriership of the polymorphism of PAI-1 was associated with lower risk for acute MI (odds ratio 0.45, 95% confidence interval 0.23-0.88, P = 0.02) after adjusting for major cardiovascular risk factors. Patients possessing the 4G allele had higher PAI-1 plasma levels (32.2 +/- 25 vs. 22.2 +/- 11.3 ng/ml, P = 0.006) but lower lipoprotein(a) levels (10.1 [2.1-29.9] vs. 15.3 [8.2-57.1] mg/dl, P = 0.03) compared to 5G/5G homozygotes. Our data indicate that the 4G allele of the PAI-1 4G/5G polymorphism is less frequent among survivors of MI at very young age compared with matched controls.
Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Athens, Greece. rallidis@ath.forthnet.gr
Loukianos S
LS
Rallidis
Argyri
A
Gialeraki
Efrosyni
E
Merkouri
George
G
Liakos
Nikolaos
N
Dagres
Dimitrios
D
Sionis
Anthi
A
Travlou
John
J
Lekakis
Dimitrios T
DT
Kremastinos
D000328:Adult; D000483:Alleles; D005260:Female; D006720:Homozygote; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000235:genetics* / Q000401:mortality; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D012307:Risk Factors
D017270:Lipoprotein(a); D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human