Excavatoids E and F: discovery of two new briaranes from the cultured octocoral Briareum excavatum.
Two new briarane-related diterpenoids, designated as excavatoids E (1) and F (2), were isolated from the cultured octocoral Briareum excavatum. The structures of compounds 1 and 2 were established on the basis of extensive spectral data analysis. Briaranes 1 and 2 were found to exhibit moderate inhibitory effects on elastase release by human neutrophils.
Graduate Institute of Marine Biotechnology and Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Checheng, Pingtung 944, Taiwan.
Ping-Jyun
PJ
Sung
Bo-Yuan
BY
Chen
Mei-Ru
MR
Lin
Tsong-Long
TL
Hwang
Wei-Hsien
WH
Wang
Jyh-Horng
JH
Sheu
Yang-Chang
YC
Wu
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010196:Pancreatic Elastase / Q000187:drug effects / Q000378:metabolism; D013057:Spectrum Analysis; D013624:Taiwan
D004224:Diterpenes; C546722:excavatoid E; C546723:excavatoid F; D010196:Pancreatic Elastase