Cerebrospinal fluid total tau is associated with shorter survival in dementia with Lewy bodies.
A pathology typical of dementia with Lewy bodies (DLB) has been demonstrated to increase mortality to a greater extent than the pathology of Alzheimer's disease (AD). However, mortality in DLB has also been shown to increase with concomitant AD pathology. Furthermore, in a recent publication, we showed that there is a robust and specific increase in CSF calcium and magnesium in DLB patients compared to both AD patients and controls. Thus, in order to explore the influence of CSF AD markers and trace element concentrations on mortality in DLB, we undertook a longitudinal prospective study of 47 clinically diagnosed DLB patients and 157 AD patients as well as 49 healthy volunteers. Both AD and DLB patients showed an increased mortality compared to the healthy controls (relative risk: 10 and 8, respectively; p < 0.001). Increased levels of CSF total tau were associated with increased mortality among the DLB patients (p < 0.05), but not among the AD patients or controls. Gender, age, MMSE score, Abeta42 concentration and phosphorylated tau, and CSF trace element concentrations did not influence survival in the obtained models.
Boström
Fredrik
F
Department of Clinical Sciences, University Hospital MAS, Malmö, Sweden. fredrik.bostrom@skane.se
Hansson
Oskar
O
Blennow
Kaj
K
Gerhardsson
Lars
L
Lundh
Thomas
T
Minthon
Lennart
L
Zetterberg
Henrik
H
Londos
Elisabet
E
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000401:mortality; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D015415:Biomarkers; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D020961:Lewy Body Disease / Q000134:cerebrospinal fluid* / Q000401:mortality*; D008297:Male; D008670:Metals / Q000134:cerebrospinal fluid; D008875:Middle Aged; D016016:Proportional Hazards Models; D012737:Sex Factors; D013054:Spectrophotometry, Atomic; D016019:Survival Analysis; D016875:tau Proteins / Q000134:cerebrospinal fluid*
D016229:Amyloid beta-Peptides; D015415:Biomarkers; D008670:Metals; D016875:tau Proteins