THE QUANTITY OF CHOLESTEROL IN THE BLOOD SERUM OF THE GUINEA PIG AS AN INHERITED CHARACTER; ITS RELATION TO NATURAL RESISTANCE TO TUBERCULOSIS, AND TO TUBERCULOSIS INFECTION.
1. Infection with tubercle bacilli of bovine type produced no alteration in the serum cholesterol content in guinea pigs. 2. Certain controlled variations in diet produced no changes in the serum cholesterol content in guinea pigs. 3. Inbred families of guinea pigs known to manifest differing resistances to tuberculosis gave differing serum cholesterol values, but no direct relationship between the two sets of phenomena could be established. 4. It seems probable that in the guinea pig the cholesterol content of the blood serum is influenced by inherited factors.
Shope
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Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.