Bipolar hypertrophic herpes: an unusual presentation of acyclovir-resistant herpes simplex type 2 in a HIV-infected patient.
Hypertrophic pseudo tumoral herpetic lesion is an uncommon presentation in immunocompromized hosts that can be refractory to established therapies. We describe bipolar anal and tonsilar herpetic tumoral lesions related to acyclovir-resistant HSV-2 in a human immunodeficiency virus-infected patient. Treatment with valacyclovir, cidofovir, and thalidomide failed and surgical excision was required.
Service des Maladies Infectieuses et Tropicales, hôpital Saint Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France.
Karine
K
Cury
Nadia
N
Valin
Joël
J
Gozlan
Isabelle
I
Jacquier
David
D
Boutolleau
Sarah
S
Guegan
Jean François
JF
Flejou
Pierre Marie
PM
Girard
D000212:Acyclovir / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001004:Anus Diseases / Q000150:complications / Q000188:drug therapy / Q000601:surgery / Q000821:virology; D002522:Chlorocebus aethiops; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000150:complications*; D006561:Herpes Simplex / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000821:virology; D018258:Herpesvirus 2, Human / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D006984:Hypertrophy; D008297:Male; D008875:Middle Aged; D014066:Palatine Tonsil / Q000473:pathology / Q000821:virology; D010608:Pharyngeal Diseases / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000821:virology; D014709:Vero Cells
D000998:Antiviral Agents; D000212:Acyclovir