Urinary tract infections in the early posttransplant period after simultaneous pancreas-kidney transplantation.
OBJECTIVE
Urinary tract infection (UTI) is among the common infection in simultaneous pancreas-kidney transplantation (SPKT).


METHODS
The study included 26 adult patients undergoing SPKT between September 2001 and December 2006. All the patients were followed prospectively for UTI during the first 4 weeks after surgery. Urine samples were investigated for bacteriologic cultures. The micro-organisms were identified in accordance with standard bacteriologic procedures. Susceptibility testing was carried out using Clinical and Laboratory Standards Institute (CLSI) procedures.


RESULTS
Among 77 urine specimens obtained from all recipients during the first month, there were 30 isolated bacterial strains. The most common were Gram-positive bacteria (53.3%) with predominance of enterococci (75%) associated with high levels of aminoglycoside resistant strains (HLAR; 58.3%) and vancomycin-resistant strains (VRE; 25%). Gram-negative bacteria were detected in 46.7% of positive cultures.


CONCLUSIONS
In our study, enterococci predominated as 75% of Gram-positive isolates. The increased proportion of multi-drug-resistant bacteria, which can caused severe UTI in patients after SPKT, may be due to the frequent use of prophylaxis of bacterial infections in patients.
Department of Medical Microbiology, Transplantation Institute, Medical University of Warsaw, 5 Chalubinskiego Street, 02-004 Warsaw, Poland. dkawecki@o2.pl
D
D
Kawecki
A
A
Kwiatkowski
G
G
Michalak
A
A
Sawicka-Grzelak
A
A
Mlynarczyk
B
B
Sokol-Leszczynska
I
I
Serafin
J
J
Czerwinski
W
W
Lisik
M
M
Bieniasz
M
M
Wszola
P
P
Domagala
W
W
Rowinski
M
M
Durlik
M
M
Luczak
A
A
Chmura
G
G
Mlynarczyk
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D002102:Cadaver; D024881:Drug Resistance, Bacterial; D005260:Female; D006094:Gram-Positive Bacteria / Q000302:isolation & purification; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000009:adverse effects* / Q000276:immunology; D014019:Tissue Donors; D014552:Urinary Tract Infections / Q000453:epidemiology*
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents