Usefulness of diffusion-weighted MR imaging in the evaluation of pulmonary lesions.
OBJECTIVE
The role of diffusion-weighted MR imaging (DWI) in the differential diagnosis of pulmonary malignant tumours and solid benign lesions was investigated.


METHODS
Sixty-two patients with 66 lesions underwent conventional MRI and DWI (diffusion factor of 0 and 500 s/mm(2)) examinations with 1.5-T MRI. The signal intensity of DWI images was observed and the apparent diffusion coefficient (ADC) values of the lesions were measured. Statistical analyses were performed with the independent samples t test, Pearson's chi-square test and receiver operating characteristic (ROC) analysis.


RESULTS
The signal intensities of pulmonary malignant tumours and solid benign lesions were not significantly different, but the ADC value of benign lesions was statistically higher than that of malignant tumours (p = 0.001). By ROC analysis, the optimal threshold of ADC was 1.400 x 10(-3) mm(2)/s and the sensitivity and specificity were 83.3% and 74.1%, respectively. There were statistical differences between small cell carcinoma (SCLC) and non-small cell carcinoma (NSCLC) as well; the former was lower than the latter (p = 0.007).


CONCLUSIONS
Our data indicate that quantitative analysis of ADC values may help diagnose or distinguish pulmonary lesions, and it also provides a promising method for characterising the pulmonary masses.
Liu
Haidong
H
Department of Radiology, General Hospital of Tianjin Medical University, Tianjin, China.
Liu
Ying
Y
Yu
Tielian
T
Ye
Ning
N
D000328:Adult; D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity