Fulminant hepatic failure induced by venlafaxine and trazodone therapy: a case report.
Although acute hepatitis may be a side effect of many medications, most cases are reversible after treatment interruption, and fulminant hepatic failure (FHF) is rare. Venlafaxine and trazodone are 2 popular antidepressant agents. Alteration of liver enzyme levels has been reported as a side effect of these drugs at normal doses. Herein we have reported the case of a 48-year-old woman without any previous history of liver disease, who developed fulminant liver failure after 4 months of venlafaxine and trazodone therapy. She required liver transplantation, a procedure that was successful with full patient recovery. The first 5 years of follow-up were uneventful. This case documented that venlafaxine and trazodone at normal doses can produce severe liver toxicity. Liver tests should be monitored regularly in patients who receive this therapy.
Detry
O
O
Department of Abdominal Surgery and Transplantation, CHU de Liège, University of Liège, Sart Tilman B35, B4000 Liège, Belgium. oli.detry@chu.ulg.ac.be
Delwaide
J
J
De Roover
A
A
Hans
M F
MF
Delbouille
M H
MH
Monard
J
J
Honoré
P
P
D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D003511:Cyclohexanols / Q000009:adverse effects*; D003863:Depression / Q000188:drug therapy; D005165:Factor V / Q000378:metabolism; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D007565:Jaundice / Q000139:chemically induced*; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000601:surgery*; D016031:Liver Transplantation; D008875:Middle Aged; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D014196:Trazodone / Q000009:adverse effects; D016896:Treatment Outcome; D000069470:Venlafaxine Hydrochloride
D001219:Aspartate Aminotransferases; D001663:Bilirubin; D003511:Cyclohexanols; D005165:Factor V; D017367:Selective Serotonin Reuptake Inhibitors; D014196:Trazodone; D000069470:Venlafaxine Hydrochloride