Taste masking of Etoricoxib by using ion-exchange resin.
The present study was carried out in order to mask the bitter taste of the Etoricoxib by complexation with cation-exchange resin, Indion 204. The drug resin complexes (DRC) were prepared by batch process and efficient drug loading was obtained by using inactivated form of resin in the drug-resin ratio 1:3.3 with 30 min swelling time of resin in 25 mL of water with 5 min stirring time. Drug-resin complexes were characterized for dissolution studies and spectral studies. Drug release from drug-resin complex in salivary pH was insufficient to impart bitter taste. Volunteers rated the drug resin complex as tasteless and agreeable.
University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar, Orissa, India. sradhanjali2002@yahoo.co.in
Sradhanjali
S
Patra
Rakesh
R
Samantaray
Saswat
S
Pattnaik
B B
BB
Barik
D000284:Administration, Oral; D002411:Cation Exchange Resins; D002626:Chemistry, Pharmaceutical; D052246:Cyclooxygenase 2 Inhibitors / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers; D004339:Drug Compounding; D000077613:Etoricoxib; D006801:Humans; D011725:Pyridines / Q000008:administration & dosage* / Q000737:chemistry; D013450:Sulfones / Q000008:administration & dosage* / Q000737:chemistry; D013649:Taste
D002411:Cation Exchange Resins; D052246:Cyclooxygenase 2 Inhibitors; D004337:Drug Carriers; D011725:Pyridines; D013450:Sulfones; D000077613:Etoricoxib