Autologous orbicularis muscle for filling facial folds-an experimental and clinical study.
OBJECTIVE
To present a technique for filling facial folds by using autologous orbicularis oculi muscle, based on an experimental model.


METHODS
two studies are presented: (1) an experimental study using 15 albino guinea-pigs from which a strip of the sural triceps muscle was removed and implanted in the subcutaneous tissue of the dorsal area. The animals were sacrificed 7, 30 and 60 days after the implantation, and the material was histologically evaluated. And (2) an interventional prospective clinical trial carried out on 20 patients referred to blepharoplasty surgery. They received autologous preseptal orbicularis muscle for filling facial folds. The results where evaluated by patients satisfaction and clinical exam.


RESULTS
the sural tricep muscle, when implanted in the subcutaneous tissue, resulted in fibrosis. The patients whom received autologous orbicularis muscle implanted for filling facial folds showed that the procedure can be successfully carried out.


CONCLUSIONS
autologous preseptal orbicularis muscle is a good material for filling facial folds. Cicatricial tissue will be formed on its implantation site, filling the tissue gap that forms the folds on the skin.
Department of Ophthalmology, Faculdade de Medicina de Botucatu- UNESP, São Paulo, Brazil. sartioli@fmb.unesp.br
Silvana Artioli
SA
Schellini
Flavio Eduardo
FE
Hirai
Erika
E
Hoyama
Maila Karina
MK
Mattos
Fernando Rodrigo
FR
Chaves
Claudia Helena
CH
Pellizon
Carlos Roberto
CR
Padovani
D000328:Adult; D000818:Animals; D019882:Blepharoplasty / Q000379:methods*; D004195:Disease Models, Animal; D004954:Esthetics; D005143:Eyelids / Q000601:surgery; D005152:Facial Muscles / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006168:Guinea Pigs; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000473:pathology / Q000637:transplantation*; D011446:Prospective Studies; D012060:Rejuvenation; D015361:Rhytidoplasty / Q000379:methods*; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome