Niemann-Pick disease, type B with TRAP-positive storage cells and secondary sea blue histiocytosis.
We present 2 cases of Niemann Pick disease, type B with secondary sea-blue histiocytosis. Strikingly, in both cases the Pick cells were positive for tartrate resistant acid phosphatase, a finding hitherto described only in Gaucher cells. This report highlights the importance of this finding as a potential cytochemical diagnostic pitfall in the diagnosis of Niemann Pick disease.
Haematology Department, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. prashant.sh@gmail.com
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Sharma
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Kar
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Dutta
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Pati
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Saxena
D000135:Acid Phosphatase / Q000032:analysis*; D000293:Adolescent; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000032:analysis*; D052537:Niemann-Pick Disease, Type B / Q000150:complications* / Q000473:pathology; D012618:Sea-Blue Histiocyte Syndrome / Q000150:complications* / Q000473:pathology; D000071681:Tartrate-Resistant Acid Phosphatase
D007527:Isoenzymes; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase