The effects of hyperbaric oxygen on tooth movement into the regenerated area after distraction osteogenesis.
OBJECTIVE
To analyze the effect of hyperbaric oxygen on newly formed bone in distracted areas surrounding the root of a moving tooth by histological and radiological analysis. It was hypothesized that the application of hyperbaric oxygen to a tooth moving into the distracted area would accelerate ossification and vascularization of newly formed bone in the distracted space.


METHODS
Ten dogs were used. After creating a 10-mm-long bone defect, a bony segment was prepared and translocated into the defect area at a rate of 1 mm/d for 10 days. Following the distraction period, tooth movement was started and the dogs were divided into two groups. The HBO group received hyperbaric oxygen; whereas, the control group did not. At 150 days after tooth movement, the distracted area around the moving tooth was evaluated radiologically and histologically. Differences between groups were confirmed by a Mann-Whitney U test.


RESULTS
Trabecular bone density and cortical and subcortical bone areas measured by peripheral quantitative computed tomography in the HBO group were significantly higher than those in the control group. Histological observations revealed regenerated bone and blood vessels formation in the tension site of the moving tooth in the HBO group. The regenerated bone structure measured by bone histomorphometry was larger and more active in bone formation in the HBO group than in the control group.


CONCLUSIONS
Applying hyperbaric oxygen to tooth movement into a distracted area appears to accelerate ossification and vascularization of regenerated bone in the that area.
Department of Maxillofacial Reconstruction and Function, Graduate School, Tokyo Medical and Dental University, Japan.
Takato
T
Inokuchi
Tatsuo
T
Kawamoto
Kazuhiro
K
Aoki
Asato
A
Aoki
Kouhei
K
Nagahama
Yoshiyuki
Y
Baba
Syouichi
S
Suzuki
Masaharu
M
Shibayama
Yoshihiro
Y
Mano
Keiichi
K
Ohya
Keiji
K
Moriyama
D000818:Animals; D015519:Bone Density; D001861:Bone Regeneration; D004285:Dogs; D005260:Female; D006931:Hyperbaric Oxygenation; D008437:Maxilla / Q000000981:diagnostic imaging*; D019857:Osteogenesis, Distraction; D014057:Tomography, X-Ray Computed; D014087:Tooth Movement Techniques