Reversible acute leukoencephalopathy as a form of presentation in cerebral amyloid angiopathy.
BACKGROUND
Cerebral amyloid angiopathy (CAA) may present as cerebral haemorrhage, cerebral infarction and periventricular white matter lesions. Reversible leukoencephalopathy is a rare manifestation of CAA.


OBJECTIVE
To describe two patients with reversible acute leukoencephalopathy as the first manifestation of CAA.


METHODS
Two consecutive patients were admitted to our neurology department with transient focal neurological symptoms. They showed reversible focal leukoencephalopathy on magnetic resonance imaging (MRI). CAA was finally diagnosed in both, and pathologically confirmed in one. The latter patient showed multiple foci of petechial bleeding in the cortex and subcortex in T2-weighted GRE sequences, suggestive of CAA.


CONCLUSIONS
Reversible acute focal leukoencephalopathy may be an infrequent clinical and radiological pattern of CAA.
Department of Neurology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain. lcano@bellvitgehospital.cat
L M
LM
Cano
S
S
Martínez-Yélamos
C
C
Majós
M A
MA
Albertí
S
S
Boluda
R
R
Velasco
F
F
Rubio
D000208:Acute Disease; D000368:Aged; D001921:Brain / Q000473:pathology*; D001929:Brain Edema / Q000209:etiology / Q000473:pathology; D016657:Cerebral Amyloid Angiopathy / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006261:Headache / Q000209:etiology / Q000473:pathology; D006801:Humans; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed