[The comparison of the expansion of polyps according to the Ki-67 and computed tomography scores].
OBJECTIVE
The disease extention in nasal polyps was compared by using the mitotic activity rates and the computed tomography scores.


METHODS
This study was conducted on 19 nasal polyposis patients (8 males, 11 females; mean age 40.0+/-13.7 years; range 20 to 63 years). The preoperative computed tomography records of the patients were evaluated according to the Lund-Mackay grading system. The polyp tissues of the same patients were stained with the Ki-67 antigen for immunohistochemical evaluation. The correlation between the radiologic results and the Ki-67 values was compared by means of the Spearman's correlation test.


RESULTS
The mean computed tomography score was observed as 14.3+/-4.7 (range 7-24). The mean Ki-67 score resulting from the immunohistochemical staining was calculated as 24.3+/-18.5 (range 3.3-73.5%). A significant correlation was determined between the Ki-67 values and the computed tomography scores. ("Spearman's" correlation factor: 0.677; p<0.001).


CONCLUSIONS
As the mitotic activity rate of nasal polyps increases, both the volume of the polyps and the computed tomography scores increase as a result of the blockage of the sinus ostiums by the increased polyp volume.
Department of Otolaryngology, Lütfi Kirdar Training and Research Hospital, Istanbul, Turkey. sedataydin63@yahoo.com
Sedat
S
Aydin
Arif
A
Sanli
Ilter
I
Tezer
Umit
U
Hardal
Nagehan Ozdemir
NO
Barişik
D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D009298:Nasal Polyps / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed / Q000379:methods; D055815:Young Adult
D019394:Ki-67 Antigen