DNA damage in horticultural farmers: a pilot study showing an association with organophosphate pesticide exposure.
A study of horticultural farmers exposed to organophosphate pesticides (OPs) and controls investigated the relationships between OP exposure, DNA damage and oxidative stress. Blood acetylcholinesterase (AChE) and urinary dialkylphosphate (DAP) levels determined exposure and 8-hydroxy-29- deoxyguanosine (8OHdG) indicated oxidative stress status. The farmers had approximately 30% lower AChE activity and increased DAP levels compared with the controls, reflecting moderate OP exposure. They had higher DNA damage than the controls and there was a significant positive relationship between DAP and DNA damage with greater than 95% power. The farmers also had a significant positive relationship between urinary DAP and 8OHdG levels.
Institute for Research on Environment and Sustainability, Newcastle University, Newcastle upon Tyne, UK.
Kathryn M
KM
Atherton
Faith M
FM
Williams
Francisco J
FJ
Egea González
Richard
R
Glass
Steve
S
Rushton
Peter G
PG
Blain
Elaine
E
Mutch
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000110:Acetylcholinesterase / Q000097:blood; D000328:Adult; D000382:Agricultural Workers' Diseases / Q000097:blood / Q000209:etiology* / Q000652:urine; D015415:Biomarkers / Q000032:analysis* / Q000097:blood / Q000652:urine; D020552:Comet Assay; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D062025:Organophosphate Poisoning; D010755:Organophosphates / Q000032:analysis / Q000652:urine; D009943:Organophosphorus Compounds / Q000652:urine; D018384:Oxidative Stress; D010575:Pesticides / Q000032:analysis / Q000506:poisoning; D010865:Pilot Projects; D013030:Spain; D055815:Young Adult
D015415:Biomarkers; D010755:Organophosphates; D009943:Organophosphorus Compounds; D010575:Pesticides; C034789:diethyl phosphate; D000080242:8-Hydroxy-2'-Deoxyguanosine; D000110:Acetylcholinesterase; D003849:Deoxyguanosine; C007477:dimethyl phosphate