Copper-mediated amidation of heterocyclic and aromatic C-H bonds.
A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C-H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs.
Howard Hughes Medical Institute, Broad Institute, Cambridge, Massachusetts 02142, USA.
Qiu
Q
Wang
Stuart L
SL
Schreiber
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000577:Amides; D006571:Heterocyclic Compounds; D006841:Hydrocarbons, Aromatic; D009942:Organometallic Compounds; D003300:Copper