The imbalance of enzymatic antioxidants in cholesteatoma.
CONCLUSIONS
Depletion of enzymatic antioxidants was observed in cholesteatoma. However, a relationship between activity of enzymatic antioxidants and the extent of bone erosion was not found.


OBJECTIVE
To measure the level of major enzymatic antioxidants in cholesteatoma, and to investigate the relationship between the level of enzymatic antioxidants and the extent of bone erosion.


METHODS
The cholesteatoma and skin samples were obtained during otologic surgeries. All cases were grouped according to the number of bone erosion sites. Samples were examined biochemically and the levels of enzymatic antioxidants were measured. The results were analyzed statistically.


RESULTS
Thirteen patients were included in the study. The mean level of superoxide dismutase in cholesteatoma and skin was 45.87 U/mg and 71.04 U/mg, respectively. When the catalase level was evaluated, the mean level was 5.04 U/g in cholesteatoma and 11.62 U/g in skin. The mean level of glutathione peroxidase in cholesteatoma and skin was 12.13 IU/g and 236.74 IU/g, respectively. All the results of cholesteatoma and skin samples were compared through non-parametric tests and statistically significant differences were found. However, a statistically significant difference between the levels of enzymatic antioxidants and the extent of bone erosion was not observed.
Eskiizmir
Görkem
G
Department of Otorhinolaryngology-Head Neck Surgery, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. gorkemeskiizmir@yahoo.com
Yuceturk
Ali Vefa
AV
Onur
Ece
E
Var
Ahmet
A
Temiz
Peyker
P
D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism*; D018424:Cholesteatoma, Middle Ear / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D004424:Ear Canal / Q000473:pathology / Q000601:surgery; D004429:Ear Ossicles / Q000473:pathology / Q000601:surgery; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012665:Semicircular Canals / Q000473:pathology / Q000601:surgery; D012867:Skin / Q000201:enzymology / Q000473:pathology; D018709:Statistics, Nonparametric; D013482:Superoxide Dismutase / Q000378:metabolism*; D013701:Temporal Bone / Q000473:pathology / Q000601:surgery; D055815:Young Adult
D000975:Antioxidants; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase