Management of hematological malignancies during pregnancy.
The management of hematological malignancies during pregnancy is a challenging endeavor, which not only requires technical skills and knowledge by the clinicians but also requires sound clinical judgment and compassion, keeping in mind the patient and family preferences and, ultimately, the wellbeing of the neonate. The incidence of hematological malignancies during pregnancy is rare, ranging from 1 in 1,000 to 1 in 10,000 deliveries, impeding the design and execution of large prospective studies. The purpose of this review is to evaluate the limited existing data and make useful suggestions in the management of acute and chronic leukemias, Hodgkin and non-Hodgkin lymphomas, plasma cell myeloma, and other hematological malignancies, such as myelodysplastic syndromes and hairy cell leukemia, during pregnancy.
Rizack
Tina
T
Division of Hematology and Oncology, The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02906, USA. trizack@lifespan.org
Mega
Anthony
A
Legare
Robert
R
Castillo
Jorge
J
D000014:Abnormalities, Drug-Induced / Q000209:etiology / Q000517:prevention & control; D000028:Abortion, Induced; D000328:Adult; D000932:Antiemetics / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D002585:Cesarean Section; D002985:Clinical Protocols; D003131:Combined Modality Therapy; D000075202:Contraindications; D019468:Disease Management; D005260:Female; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced / Q000517:prevention & control; D007937:Leukapheresis; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy* / Q000453:epidemiology / Q000628:therapy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000453:epidemiology / Q000628:therapy; D011256:Pregnancy Outcome; D011264:Pregnancy Trimesters
D000932:Antiemetics; D000970:Antineoplastic Agents