The KDEL receptor: new functions for an old protein.
The KDEL receptor is a seven-transmembrane-domain protein that was first described about 20 years ago. Its well-known function is to retrotransport chaperones from the Golgi complex to the endoplasmic reticulum. Recent studies, however, have suggested that the KDEL receptor has additional functions. Indeed, we have demonstrated that chaperone-bound KDEL receptor triggers the activation of Src family kinases on the Golgi complex. This activity is essential in the regulation of Golgi-to-plasma membrane transport. However, the identification of different KDEL receptor interactors that are inconsistent with these established functions opens the possibility of further receptor activities.
Unit of Genomic Approaches to Membrane Traffic, Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (CH), Italy.
Mirco
M
Capitani
Michele
M
Sallese
D000818:Animals; D004705:Endocytosis; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D018832:Molecular Chaperones / Q000378:metabolism; D021381:Protein Transport; D018000:Receptors, Peptide / Q000737:chemistry / Q000378:metabolism*; D019061:src-Family Kinases / Q000378:metabolism
C064459:KDEL receptor; D018832:Molecular Chaperones; D018000:Receptors, Peptide; D019061:src-Family Kinases