Biodosimetric tools for a fast triage of people accidentally exposed to ionising radiation. Statistical and computational aspects.
Consideration of statistical methodology is essential for the application of cytogenetic and other biodosimetry techniques to triage for mass casualty situations. This is because the requirement for speed and accuracy in biodosimetric triage necessarily introduces greater uncertainties than would be acceptable in day-to-day biodosimetry. Additionally, in a large scale accident type situation, it is expected that a large number of laboratories from around the world will assist and it is likely that each laboratory will use one or more different dosimetry techniques. Thus issues arise regarding combination of results and the associated errors. In this article we discuss the statistical and computational aspects of radiation biodosimetry for triage in a large scale accident-type situation. The current status of statistical analysis techniques is reviewed and suggestions are made for improvements to these methods which will allow first responders to estimate doses quickly and reliably for suspected exposed persons.
Health Protection Agency, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, United Kingdom. liz.ainsbury@hpa.org.uk
Elizabeth A
EA
Ainsbury
J Francesc
JF
Barquinero
D003199:Computer Systems; D003582:Cytogenetics; D003627:Data Interpretation, Statistical; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D015233:Models, Statistical; D018788:Radioactive Hazard Release; D011874:Radiometry / Q000379:methods*; D014218:Triage / Q000379:methods*