The CBL-CIPK Ca(2+)-decoding signaling  network: function and perspectives.
Calcium serves as a versatile messenger in many adaptation and developmental processes in plants. Cellular calcium signals are detected and transmitted by calcium-binding proteins functioning as sensor molecules. The family of calcineurin B-like (CBL) proteins represents a unique group of calcium sensors and contributes to the decoding of calcium transients by interacting with and regulating the family of CBL-interacting protein kinases (CIPKs). In higher plants, CBL proteins and CIPKs form a complex signaling network that allows for flexible but specific signal-response coupling during environmental adaptation reactions. This review presents novel findings concerning the evolution of this signaling network and key insights into the physiological function of CBL-CIPK complexes. These aspects will be presented and discussed in the context of emerging functional principles governing efficient and specific information processing in this signaling system.
Weinl
Stefan
S
Universität Münster, Institut für Botanik und Botanischer Garten, Schlossplatz 4, 48149 Münster, Germany.
Kudla
Jörg
J
Universität Münster, Institut für Botanik und Botanischer Garten, Schlossplatz 4, 48149 Münster, Germany.
D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D005075:Biological Evolution; D019703:Calcineurin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D020013:Calcium Signaling; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D023281:Genomics; D008954:Models, Biological; D010802:Phylogeny; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010944:Plants / Q000235:genetics / Q000378:metabolism*; D011494:Protein Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
D029681:Arabidopsis Proteins; D002135:Calcium-Binding Proteins; D010940:Plant Proteins; D011494:Protein Kinases; D019703:Calcineurin