The CST complex and telomere maintenance: the exception becomes the rule.
Telomeres are bound and stabilized by two complexes-CST and shelterin-thought to be species specific and virtually unrelated. In this issue of Molecular Cell, Miyake et al. (2009) and Surovtseva et al. (2009) provide evidence that these complexes coexist and function at telomeres in many species.
Wellinger
Raymund J
RJ
Department of Microbiology and Infectious Diseases, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada. raymund.wellinger@usherbrooke.ca
D000818:Animals; D017360:Arabidopsis / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D006801:Humans; D051379:Mice; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000378:metabolism*; D051716:Replication Protein A / Q000378:metabolism; D016615:Telomere / Q000378:metabolism*; D034501:Telomere-Binding Proteins / Q000737:chemistry / Q000378:metabolism*
D029681:Arabidopsis Proteins; D002868:Chromosomal Proteins, Non-Histone; D046912:Multiprotein Complexes; D051716:Replication Protein A; C534225:STN1 protein, Arabidopsis; D034501:Telomere-Binding Proteins