Modulation of nitrosative/oxidative stress in the lung of hyperglycemic rabbits by two antidiabetics, pioglitazone and repaglinide.
The lungs are involved in diabetes in the cause of the complex phenomena diabetes generates. In the present study, hyperglycemia inhibited pulmonary antioxidants, including superoxide dismutase, catalase, glutathione peroxidase, and glutathione. These effects were accompanied by significant elevation of lipid peroxidation, total nitrites, and nitrotyrosine levels. The study investigated the effects of 2 oral antidiabetics, pioglitazone and repaglinide, on the mentioned parameters. It is concluded that pioglitazone exerts protective effect in the lung by inhibiting nitrosative stress and normalizing the nitrites and nitrotyrosine levels. Administration of repaglinide prevents oxidative and, to a smaller extent, nitrosative changes.
Department of Medicinal Chemistry, Medical University of Lublin, Lublin, Poland. anna.gumieniczek@um.lub.pl
Anna
A
Gumieniczek
Marta
M
Krzywdzińska
Magdalena
M
Nowak
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002219:Carbamates / Q000008:administration & dosage / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006943:Hyperglycemia / Q000188:drug therapy* / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D000077205:Pioglitazone; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D026361:Reactive Nitrogen Species / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D045162:Thiazolidinediones / Q000008:administration & dosage / Q000494:pharmacology*; D014443:Tyrosine / Q000031:analogs & derivatives / Q000378:metabolism
D001786:Blood Glucose; D002219:Carbamates; D007004:Hypoglycemic Agents; D010880:Piperidines; D026361:Reactive Nitrogen Species; D045162:Thiazolidinediones; C002744:3-nitrotyrosine; D014443:Tyrosine; C072379:repaglinide; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D000077205:Pioglitazone