[Structural feature and biological function of PPP2R5C gene].
PPP2R5C is one of the members of regulatory subunits of protein phosphatase 2A (PP2A), which plays a critical role in cell proliferation, differentiation and transformation, based on its induction of dephosphorylation of P53 at various residues. Recently, it was characterized that the alteration of expression pattern of PPP2R5C is associated with cell malignant transformation, thus PPP2R5C was thought as a marker for progressive disease in B-CLL. In this article the gene structure and biological function of PPP2R5C as well as relation of PPP2R5C with genesis and development of cancer were discussed.
Yang-Qiu
YQ
Li
Yu-Bing
YB
Zhou
Li-Jian
LJ
Yang
D002461:Cell Line, Transformed; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D006801:Humans; D015394:Molecular Structure; D054648:Protein Phosphatase 2 / Q000235:genetics*; D021122:Protein Subunits
D021122:Protein Subunits; C503981:PPP2R5C protein, human; D054648:Protein Phosphatase 2