Infant anaplastic large cell lymphoma with hemophagocytic syndrome.
Anaplastic large cell lymphoma (ALCL), anaplastic lymphoma kinase (ALK)-positive, is uncommon in infancy. We present an unusual occurrence of infant ALCL, ALK-positive, associated with hemophagocytic syndrome. To the best of our knowledge, there have been no cases of infant ALCL, ALK-positive, described that have been associated with hemophagocytic syndrome. Particularly in this age group, primary hemophagocytic syndrome is also a consideration, which raises particular differential diagnostic considerations.
Princess Margaret Hospital and PathWest, Roberts Road, Subiaco, Western Australia 6008, Australia. tzesk@member.rcpa.edu.au
Tze S
TS
Khor
Angela J
AJ
Alessandri
Gareth P
GP
Jevon
D000077548:Anaplastic Lymphoma Kinase; D014408:Biomarkers, Tumor / Q000378:metabolism; D002889:Chromosomes, Human, Pair 2; D005183:Failure to Thrive; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D017730:Ki-1 Antigen / Q000378:metabolism; D008198:Lymph Nodes / Q000473:pathology; D051359:Lymphohistiocytosis, Hemophagocytic / Q000235:genetics / Q000473:pathology*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D008297:Male; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases; D014178:Translocation, Genetic
D014408:Biomarkers, Tumor; D017730:Ki-1 Antigen; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases