One-pot green synthesis of biocompatible arginine-stabilized magnetic nanoparticles.
A green one-step approach has been developed for the synthesis of amino-functionalized magnetite nanoparticles. The synthesis was accomplished by simply mixing FeCl2 with arginine under ambient conditions. It was found that the Fe2+/arginine molar ratio, reaction duration and temperature greatly influence the size, morphology and composition of magnetic nanoparticles. The arginine-stabilized magnetic nanoparticles were characterized by transmission electron microscopy, x-ray diffraction, x-ray photoelectron spectroscopy, thermogravimetric analysis, and Fourier transform infrared spectroscopy techniques. The results show that the prepared nanoparticles are spherically shaped with a nearly uniform size distribution and pure magnetite phase. The presence of arginine on the magnetic nanoparticle surface has been confirmed and the amount of surface arginine varies with the Fe2+/arginine molar ratio. The surface amine densities are calculated to be 5.60 and 7.84 micromol mg(-1) for magnetic nanoparticles prepared at 1:1 and 1:2 Fe2+/arginine molar ratio, respectively. The as-synthesized nanoparticles show superparamagnetic behavior at room temperature and good solubility in water. In addition, using a similar synthesis procedure, we have been able to synthesize superparamagnetic manganese and cobalt ferrite nanoparticles.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, People's Republic of China.
Zhongjun
Z
Wang
Hui
H
Zhu
Xiaolei
X
Wang
Fan
F
Yang
Xiurong
X
Yang
D000588:Amines / Q000737:chemistry; D001120:Arginine / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D003035:Cobalt / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry; D055772:Green Chemistry Technology / Q000379:methods*; D006367:HeLa Cells; D006801:Humans; D008280:Magnetics; D008345:Manganese / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D000588:Amines; D001672:Biocompatible Materials; D005290:Ferric Compounds; C001215:ferrite; D003035:Cobalt; D008345:Manganese; D001120:Arginine