1,3-Dipolar cycloadditions: applications to the synthesis of antiviral agents.
In the present perspective the advances and real possibilities of 1,3-dipolar cycloadditions as key steps in the total synthesis of virus inhibitors are described. Azides, nitrones, and azomethine ylides are the most appropriate 1,3-dipoles for the synthesis of privileged structures with the highest biological responses against viruses.
Departamento de Química Orgánica and Instituto de Síntesis Orgánica, Facultad de Ciencias, Universidad de Alicante, 03080-Alicante, Spain. cnajera@ua.es
Carmen
C
Nájera
José M
JM
Sansano
D000475:Alkenes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry
D000475:Alkenes; D000480:Alkynes; D000998:Antiviral Agents; D009930:Organic Chemicals