Preeclampsia and risk of developing subsequent diabetes.
OBJECTIVE
Determine whether preeclampsia is associated with developing diabetes.


METHODS
Subsequent diabetes was ascertained using ICD-9 codes, pharmacy and glucose data in a retrospective cohort study of 2,032 women with preeclampsia and 29,431 without preeclampsia.


RESULTS
During a median follow-up of 8.2 years, 342 women developed diabetes. Preeclampsia was associated with a higher risk of diabetes adjusting for age, primigravidity, and gestational diabetes (hazard ratio, HR 1.82, 95%CI 1.26, 2.62) and in women without gestational diabetes (n = 30,109; HR 1.86, 95%CI 1.22, 2.84).


CONCLUSIONS
Women with preeclampsia have greater risk of developing diabetes, even in the absence of gestational diabetes.
Department of Obstetrics & Gynecology, University of Washington, Seattle, WA 98195-6460, USA. darcarr@u.washington.edu
D B
DB
Carr
K M
KM
Newton
K M
KM
Utzschneider
J
J
Tong
F
F
Gerchman
S E
SE
Kahn
T R
TR
Easterling
S R
SR
Heckbert
D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000378:metabolism; D016640:Diabetes, Gestational / Q000378:metabolism*; D005260:Female; D006801:Humans; D038801:International Classification of Diseases; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D012189:Retrospective Studies; D012306:Risk
D001786:Blood Glucose