Epithelial-mesenchymal transition in mouse mammary tumorigenesis.
Epithelial-mesenchymal transition tumorigenesis in the mouse has been described for over 100 years using various terms and with little comprehension of the underlying mechanisms. Recently, epithelial-mesenchymal transition tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective and the current observations in the context of some of the key molecular biology. The biology of mouse mammary epithelial-mesenchymal transition tumorigenesis is discussed with comparisons to human breast cancer.
Department of Veterinary Pathology, Hygiene and Public Health, Section of Veterinary and Avian Pathology, Faculty of Veterinary Medicine, University of Milan, Via Celoria, 10 20133 Milano, Italy.
Enrico
E
Radaelli
Patrizia
P
Damonte
Robert D
RD
Cardiff
D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology; D002454:Cell Differentiation / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D004848:Epithelium / Q000473:pathology*; D005260:Female; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000473:pathology*; D008648:Mesoderm / Q000473:pathology*; D008679:Metaplasia; D051379:Mice