Influence of process variables on release properties of paracetamol tablets.
A 2(3) factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), binder concentration (c) and relative density of tablet (d) on the disintegration time (DT) and dissolution times, t1, t50 and t90, of paracetamol tablet formulations. The factorial design was also used to study the quantitative effects of pregelatinization of starch binders on these parameters, i.e., N, c and d. In general, the most common ranking of the individual effects on DT, t1, t50 and t90 for native/native, pregelatinized/pregelatinized and native/pregelatinized starch binder formulations was c > d > N. For interaction effects, the most common ranking was N-c > c-d > N-d for all formulations. The results generally showed that c can considerably affect DT, t1, t50 and t90 of the tablets.
Department of Pharmaceutics, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria. galebiowu@yahoo.co.uk
Gbenga
G
Alebiowu
Oludele Adelanwa
OA
Itiola
D000082:Acetaminophen / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D000465:Algorithms; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage* / Q000737:chemistry; D005079:Excipients; D010943:Plantago; D011208:Powders; D012015:Reference Standards; D012995:Solubility; D045868:Sorghum; D013213:Starch / Q000737:chemistry*; D013607:Tablets; D003313:Zea mays
D018712:Analgesics, Non-Narcotic; D005079:Excipients; D011208:Powders; D013607:Tablets; D000082:Acetaminophen; D013213:Starch