Spray drying technique: II. Current applications in pharmaceutical technology.
This review presents current applications of spray drying in pharmaceutical technology. The topics discussed include the obtention of excipients and cospray dried composites, methods for increasing the aqueous solubility and bioavailability of active substances, and modified release profiles from spray-dried particles. This review also describes the use of the spray drying technique in the context of biological therapies, such as the spray drying of proteins, inhalable powders, and viable organisms, and the modification of the physical properties of dry plant extracts.
Sollohub
Krzysztof
K
Department of Pharmaceutical Technology, Medical University of Gdansk, Gdansk, Poland.
Cal
Krzysztof
K
D000280:Administration, Inhalation; D001682:Biological Availability; D003890:Desiccation / Q000295:instrumentation* / Q000379:methods*; D004339:Drug Compounding; D005079:Excipients; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry; D011208:Powders; D011506:Proteins / Q000008:administration & dosage / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000639:trends*; D014612:Vaccines / Q000008:administration & dosage / Q000737:chemistry
D005079:Excipients; D010936:Plant Extracts; D011208:Powders; D011506:Proteins; D014612:Vaccines