Influence of Magnolol on the bystander effect induced by alpha-particle irradiation.
In this work, the influence of Magnolol on the bystander effect in alpha-particle irradiated Chinese hamster ovary (CHO) cells was examined. The bystander effect was studied through medium transfer experiments. Cytokinesis-block micronucleus (CBMN) assay was performed to quantify the chromosome damage induced by alpha-particle irradiation. Our results showed that the alpha-particle induced micronuclei (MN) frequencies were suppressed with the presence of Magnolol.
Wong
T P W
TP
Department of Physics and Materials Science, City University of Hong Kong, Kowloon Tong, Hong Kong.
Law
Y L
YL
Tse
A K W
AK
Fong
W F
WF
Yu
K N
KN
D000512:Alpha Particles; D000818:Animals; D001713:Biphenyl Compounds / Q000008:administration & dosage*; D024201:Bystander Effect / Q000187:drug effects* / Q000528:radiation effects; D016466:CHO Cells; D002869:Chromosome Aberrations / Q000187:drug effects* / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D017705:Lignans / Q000008:administration & dosage*; D011836:Radiation Tolerance / Q000187:drug effects*; D011837:Radiation-Protective Agents / Q000008:administration & dosage
D001713:Biphenyl Compounds; D017705:Lignans; D011837:Radiation-Protective Agents; C005498:magnolol