Vasoproliferative retinal tumours in a Swedish population.
OBJECTIVE
To describe the clinical appearance and the visual outcome of a cohort of patients with vasoproliferative retinal tumours (VPRTs) that were diagnosed and treated between 2002 and 2007 at the University Hospital of Örebro.


METHODS
Nine patients with diagnosed VPRTs were included in a retrospective study. The mean age at the time of diagnosis was 50.2 years (range 7-74 years). Follow-up time ranged between 14 and 83 months (mean 42.6). Nine out of ten eyes received cryotherapy; six eyes were also treated with photocoagulation. One patient was treated with intravitreal injections of ranibizumab (Lucentis(®)) and another was referred for brachytherapy. Because of persisting macular oedema, one eye was treated with intravitreal injection of triamcinolon.


RESULTS
Of the treated eyes, one had anterior uveitis, six had macular oedema at baseline and four had an exudative retinal detachment at the time of diagnosis. Seven eyes underwent vitrectomy because of epiretinal membranes. Visual acuity at diagnosis was 0.21 (mean) (range 0.02-0.6) and at latest check-up 0.30 (mean) (range light perception (LP)-1.0), with improvement in six eyes and deterioration in two. Two out of four patients with retinal detachment were successfully treated surgically.


CONCLUSIONS
VPRTs are benign intraretinal changes. Several complications are associated with this condition. All patients in this study had symptom-giving tumours and six patients (six eyes) already had profound macular oedema at presentation. In these cases, when complications have already developed, the final visual prognosis is poor, thereby making it important to detect these tumours early. The patient who received anti-vascular endothelial growth factor (VEGF; Lucentis) therapy showed a slow improvement and distinct regression in exudations during the follow-up time. However, no increase in visual acuity was seen. At latest examination a peripheral exudative retinal detachment was still observed. Whether anti-VEGF treatment is effective, as either an alternative or complementary therapy, must be established in the future.
Department of Ophthalmology, Örebro University Hospital, Sweden. karim.makdoumi@orebroll.se
Karim
K
Makdoumi
Sven
S
Crafoord
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D001918:Brachytherapy; D002648:Child; D017679:Cryotherapy; D019773:Epiretinal Membrane / Q000175:diagnosis; D005500:Follow-Up Studies; D006391:Hemangioma / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D006801:Humans; D017075:Laser Coagulation; D008269:Macular Edema / Q000175:diagnosis; D008875:Middle Aged; D000069579:Ranibizumab; D019572:Retinal Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D012189:Retrospective Studies; D013548:Sweden / Q000453:epidemiology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000069579:Ranibizumab