KDIGO clinical practice guideline for the care of kidney transplant recipients: a summary.
The 2009 Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline on the monitoring, management, and treatment of kidney transplant recipients is intended to assist the practitioner caring for adults and children after kidney transplantation. The guideline development process followed an evidence-based approach, and management recommendations are based on systematic reviews of relevant treatment trials. Critical appraisal of the quality of the evidence and the strength of recommendations followed the Grades of Recommendation Assessment, Development, and Evaluation (GRADE) approach. The guideline makes recommendations for immunosuppression and graft monitoring, as well as prevention and treatment of infection, cardiovascular disease, malignancy, and other complications that are common in kidney transplant recipients, including hematological and bone disorders. Limitations of the evidence, especially the lack of definitive clinical outcome trials, are discussed and suggestions are provided for future research. This summary includes a brief description of methodology and the complete guideline recommendations but does not include the rationale and references for each recommendation, which are published elsewhere.
Hennepin County Medical Center, Department of Medicine, Minneapolis, Minnesota, USA.
Bertram L
BL
Kasiske
Martin G
MG
Zeier
Jeremy R
JR
Chapman
Jonathan C
JC
Craig
Henrik
H
Ekberg
Catherine A
CA
Garvey
Michael D
MD
Green
Vivekanand
V
Jha
Michelle A
MA
Josephson
Bryce A
BA
Kiberd
Henri A
HA
Kreis
Ruth A
RA
McDonald
John M
JM
Newmann
Gregorio T
GT
Obrador
Flavio G
FG
Vincenti
Michael
M
Cheung
Amy
A
Earley
Gowri
G
Raman
Samuel
S
Abariga
Martin
M
Wagner
Ethan M
EM
Balk
D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000592:standards*; D011183:Postoperative Complications / Q000628:therapy