Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists.
The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.
Van Ryssen
Michael P
MP
EaStCHEM and School of Chemistry, Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK.
Avlonitis
Nicolaos
N
Giniatullin
Rashid
R
McDougall
Craig
C
Carr
James L
JL
Stanton-Humphreys
Megan N
MN
Borgström
Emma L A
EL
Brown
C Tom A
CT
Fayuk
Dmitriy
D
Surin
Alexander
A
Niittykoski
Minna
M
Khiroug
Leonard
L
Conway
Stuart J
SJ
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002211:Capsaicin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D054879:Halogenation / Q000187:drug effects; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D007834:Lasers; D008024:Ligands; D008027:Light; D008564:Membrane Potentials / Q000187:drug effects; D010782:Photolysis / Q000187:drug effects / Q000528:radiation effects*; D051381:Rats; D017208:Rats, Wistar; D050916:TRPV Cation Channels / Q000819:agonists* / Q000037:antagonists & inhibitors*; D014276:Trigeminal Nerve / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects
D008024:Ligands; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; D002211:Capsaicin; C040937:nonivamide; D002118:Calcium