Bioactive flavonoids from Satureja atropatana Bonge.
From the ethyl acetate and methanol extract of the aerial parts of Satureja atropatana Bonge, which belongs to the Lamiaceae family, four flavonoids were isolated. Their structures were determined to be 5,6,3'-trihydroxy-7,8,4'-trimethoxyflavone (1), 5,6-dihydroxy-7,8,3',4'-tetramethoxyflavone or 5-desmethoxynobiletin (2), 5,6,4'-trihydroxy-7,8,3'-trimethoxyflavone or thymonin (3) and luteolin (4) using (1)H and (13)C-NMR and MS spectra. Brine shrimp cytotoxicity effects of the crude extracts and isolated compounds were examined. Berberine hydrochloride (LC(50) = 26 microg mL(-1)) was used as a positive control. Among them, compounds 2 (199 microg mL(-1)) and 3 (157 microg mL(-1)) were effective against Artemia salina larva.
Faculty of Pharmacy, Medicinal Plants Research Center, Medical Sciences/University of Tehran, Tehran, Iran. goharii_a@sina.tums.ac.ir
Ahmad R
AR
Gohari
Soodabeh
S
Saeidnia
Mahmood R
MR
Gohari
Fahimeh
F
Moradi-Afrapoli
Maryam
M
Malmir
Abbass
A
Hadjiakhoondi
D000818:Animals; D001156:Artemia / Q000187:drug effects*; D047309:Flavones / Q000737:chemistry / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D031362:Satureja / Q000737:chemistry*
C517790:5,6-dihydroxy-7,8,3',4'-tetramethoxyflavone; D047309:Flavones; D005419:Flavonoids; D010936:Plant Extracts