MRI contrast agent delivery using spore capsules: controlled release in blood plasma.
The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is slowly released in plasma due to enzymatic digestion of the capsule.
Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK HU6 7RX.
Mark
M
Lorch
Matthew J
MJ
Thomasson
Alberto
A
Diego-Taboada
Sylvain
S
Barrier
Stephen L
SL
Atkin
Grahame
G
Mackenzie
Stephen J
SJ
Archibald
D001704:Biopolymers / Q000737:chemistry*; D002338:Carotenoids / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D019786:Gadolinium DTPA / Q000097:blood / Q000737:chemistry*; D008279:Magnetic Resonance Imaging
D001704:Biopolymers; D003287:Contrast Media; D004337:Drug Carriers; C009800:sporopollenin; D002338:Carotenoids; D019786:Gadolinium DTPA