Cerebrospinal fluid maraviroc concentrations in HIV-1 infected patients.
In order to assess the penetration of maraviroc to the central nervous system, we measured maraviroc concentrations in cerebrospinal fluid (CSF) and plasma. Concentrations were determined by liquid chromatography tandem mass spectrometry (lower limit of quantitation 1.25 ng/ml) in seven paired CSF and plasma samples. The median plasma maraviroc concentration was 94.9 ng/ml (range 21.4-478.0) and the median CSF concentration was 3.63 ng/ml (range 1.83-12.2). CSF samples exceeded the median EC90 for maraviroc (0.57 ng/ml) by at least three-fold. The CSF levels of maraviroc found in this study likely contribute to viral suppression in the CSF.
Department of Infectious Diseases, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. aylin.yilmaz@gu.se
Aylin
A
Yilmaz
Victoria
V
Watson
Laura
L
Else
Magnus
M
Gisslèn
D000328:Adult; D065100:CCR5 Receptor Antagonists; D003510:Cyclohexanes / Q000097:blood / Q000134:cerebrospinal fluid*; D023581:HIV Fusion Inhibitors / Q000097:blood / Q000134:cerebrospinal fluid*; D015658:HIV Infections / Q000097:blood / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D000077592:Maraviroc; D013058:Mass Spectrometry; D008875:Middle Aged; D010865:Pilot Projects; D014230:Triazoles / Q000097:blood / Q000134:cerebrospinal fluid*
D065100:CCR5 Receptor Antagonists; D003510:Cyclohexanes; D023581:HIV Fusion Inhibitors; D014230:Triazoles; D000077592:Maraviroc