STUDIES UPON EXPERIMENTAL PNEUMONIA IN RABBITS : V. THE ROLE OF THE LEUCOCYTE IN EXPERIMENTAL PNEUMONIA. THE RELATION OF THE NUMBER OF ORGANISMS INJECTED TO THE MORTALITY.
1. The importance of the leucocyte in the resistance of animals to experimental pneumonia is emphasized by the fact that animals treated with benzol, a leucotoxic substance, rapidly succumb to the disease, while animals treated in like manner with toluol, a very similar chemical substance causing no leucopenia, show no decreased resistance. 2. The rôle of the leucocyte in the resistance of animals to experimental pneumonia is further emphasized by the fact that animals that respond to the pneumococcus infection with a leucocytosis, as occurs after the repeated injection of toluol, are more resistant to the pneumonia. Further, the hyperleucocytosis produced by repeated injection of nutrose before the production of pneumonia likewise seems to increase the resistance of the animals. 3. Experimental pneumonia is not necessarily fatal in rabbits. The factors determining the outcome of the disease are numerous; among these is the number of bacteria inoculated. Animals receiving small doses usually survive, while those receiving comparatively large numbers usually succumb.
Pathological Laboratory of Johns Hopkins University, Baltimore.
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Kline
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Winternitz