THE USE OF HISTAMINE AS A STANDARD TEST FOR DIMINISHED RESISTANCE IN SUPRARENALECTOMIZED RATS.
Of all the drugs thus far used in testing the resistance of suprarenalectomized rats, histamine has been found to be the most satisfactory. It is a readily obtainable and comparatively stable drug, producing characteristic symptoms. Its M.L.D. for a given strain of rats can be established within narrow limits, and the difference between the M.L.D. for normal and suprarenalectomized rats is comparatively great (1:20).
Division of Laboratories of Montefiore Hospital, New York.
J
J
Marmorston-Gottesman
J
J
Gottesman