Impact of buccal glucose spray, liquid sugars and dextrose tablets on the evolution of plasma glucose concentration in healthy persons.
OBJECTIVE
The purpose of this prospective controlled trial was to assess the efficacy of three commercially available glucose products, (1) buccal glucose spray, (2) liquid sugars, and (3) dextrose tablet, on the evolution of plasma glucose concentration (PG).


METHODS
Sixteen healthy volunteers aged 21.8 +/- 0.78 y (mean +/- SE), BMI 23.5 +/- 0.84 kg/m(2), tested their PG over the course of 3 sets of 4 sessions (S) each: S(0)-control fasting, S(1)-buccal administration of 10 glucose spray-doses (0.84 g of glucose) without swallowing; S(2-) consumption of 1 sachet (13 ml) of liquid sugar (ca. 5.2 g glucose, 5.2 g fructose, 5.2 g sucrose); S(3-) consumption of one dextrose tablet (6 g). PG was tested in finger-prick capillary blood using a personal glucometer Linus at the start, and at 5, 10, 15, 20 and 30 min. The means of 3 respective sessions for each of the 16 subjects were analyzed.


RESULTS
The Wilcoxon signed rank test revealed no significant differences between changes in the mean PG at the start vs. 5-minute interval either in control, or any intervention sessions. Analysis of regression coefficients after 30 min compared to the control session, demonstrated an increase in PG with the sachet of liquid sugars (0.068 mmol/l/min, p = 0.001) which was greater than a single dextrose tablet (0.052 mmol/l/min, p = 0.002), but no significant PG increase was found after buccal glucose spray.


CONCLUSIONS
Liquid sugars or dextrose tablets, but not the buccal glucose spray, are effective means to increase PG within 10 minutes after ingestion.
Department of Physiology, Palacky University, Olomouc, Czech Republic. rudolf.chlup@fnol.cz
Rudolf
R
Chlup
Jana
J
Zapletalova
Karolina
K
Peterson
Iveta
I
Poljakova
Eva
E
Lenhartova
Adam
A
Tancred
Russel
R
Perera
Jan
J
Smital
D000336:Aerosols; D001786:Blood Glucose / Q000187:drug effects*; D002241:Carbohydrates / Q000008:administration & dosage; D002610:Cheek; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D012016:Reference Values; D012996:Solutions; D013607:Tablets; D055815:Young Adult
D000336:Aerosols; D001786:Blood Glucose; D002241:Carbohydrates; D012996:Solutions; D013607:Tablets; D005947:Glucose