Longitudinal study of growth of children with unilateral cleft-lip palate from birth to two years of age.
OBJECTIVE
To study the growth of children with complete unilateral cleft lip and palate (UCLP) from birth to 2 years of age and to construct specific UCLP growth curves.


METHODS
Physical growth was a secondary outcome measure of a National Institutes of Health-sponsored longitudinal, prospective clinical trial involving the University of Florida (United States) and the University of São Paulo (Brazil).


METHODS
Six hundred twenty-seven children with UCLP, nonsyndromic, both genders.


METHODS
Length, weight, and head circumference were prospectively measured for a group of children enrolled in a clinical trial. Median growth curves for the three parameters (length, weight, head circumference) were performed and compared with the median for the National Center for Health Statistics (NCHS) curves. The median values for length, weight, and head circumference at birth and 6, 12, 18, and 24 months of age were plotted against NCHS median values and statistically compared at birth and 24 months.


METHODS
Hospital de Reabilitação de Anomalias Craniofaciais, Universidade de São Paulo, Bauru, Brazil (HRAC-USP).


RESULTS
At birth, children of both genders with UCLP presented with smaller body dimensions in relation to NCHS median values, but the results suggest a catch-up growth for length, weight, and head circumference for girls and for weight (to some degree) and head circumference for boys.


CONCLUSIONS
Weight was the most compromised parameter for both genders, followed by length and then head circumference. There was no evidence of short stature. This study established growth curves for children with UCLP.
Hospital de Reabilitação de Anomalias Craniofaciais-Universidade de São Paulo, CEP: 17043-900, Bauru, São Paulo, Brazil. marquesi@usp.br
Ilza L
IL
Marques
John A
JA
Nackashi
Hilton C
HC
Borgo
Angela P M C
AP
Martinelli
Maria I
MI
Pegoraro-Krook
William N
WN
Williams
Jeniffer C R
JC
Dutka
Michael B
MB
Seagle
Telma V
TV
Souza
Luis A
LA
Garla
José S M
JS
Neto
Marcos L N
ML
Silva
Maria I G
MI
Graciano
Jacquelyn
J
Moorhead
Sílvia H A
SH
Piazentin-Penna
Mariza R
MR
Feniman
Maria C
MC
Zimmermann
Cristina G A
CG
Bento-Gonçalves
Maria C M
MC
Pimentel
Steve
S
Boggs
José C
JC
Jorge
Patrick J
PJ
Antonelli
Jonathan
J
Shuster
D001938:Brazil / Q000453:epidemiology; D002657:Child Development; D002971:Cleft Lip / Q000453:epidemiology / Q000503:physiopathology*; D002972:Cleft Palate / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D005431:Florida / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D011446:Prospective Studies