Hormonal regulation of microRNA biogenesis.
In this issue of Molecular Cell, Yamagata et al. (2009) provide insight into the complex posttranscriptional regulation of miRNA biogenesis by showing that the processing of a subset of miRNAs is inhibited by the estrogen receptor.
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH4 2XU, UK.
Sara
S
Macias
Gracjan
G
Michlewski
Javier F
JF
Cáceres
D020413:3' Untranslated Regions / Q000378:metabolism; D000818:Animals; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D004967:Estrogens / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D008957:Models, Genetic; D043244:Ribonuclease III / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics
D020413:3' Untranslated Regions; D047628:Estrogen Receptor alpha; D004967:Estrogens; D035683:MicroRNAs; D042461:Vascular Endothelial Growth Factor A; C513400:Drosha protein, mouse; D043244:Ribonuclease III