Physicochemical characterization and in vitro dissolution behaviour of celecoxib-beta-cyclodextrin inclusion complexes.
In this study, attempts were made to investigate the effects of beta-cyclodextrin (beta-CD) on the aqueous solubility and dissolution rate of celecoxib. Inclusion complexes were prepared by the kneading method and characterized by SEM, NMR, IR, DSC, and X-ray powder diffraction. Dissolution rate of the complexes was significantly greater than that of the corresponding physical mixtures and pure drug, indicating that the formation of inclusion complex increased the solubility of the poorly soluble drug celecoxib.
Sinha
Vivek Ranjan
VR
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. vr_sinha@yahoo.com
Anitha
R
R
Ghosh
Soma
S
Amita
Kumria
Rachana
R
Bhinge
Jayant Rajaram
JR
Kumar
Manoj
M
D002152:Calorimetry, Differential Scanning; D000068579:Celecoxib; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D011720:Pyrazoles / Q000737:chemistry*; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013449:Sulfonamides / Q000737:chemistry*; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins
D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D047392:beta-Cyclodextrins; D000068579:Celecoxib