ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study.
BACKGROUND
Rs619203 (Cys2229Ser) and rs529038 (Asp2213Asn) polymorphisms in the ROS1 gene have been studied in relation to myocardial infarction (MI) yielding inconsistent results. We investigated the role of ROS1 rs529038 polymorphism in coronary artery disease (CAD) in Greeks using a case-control study.


METHODS
Genotyping for rs529038 polymorphism was performed using a multiplex PCR technique in patients with CAD (n=294) and controls (n=311). Logistic regression analysis was used to calculate crude and adjusted odds ratios (ORs).


RESULTS
Logistic regression analysis did not show any statistically significant effect of ROS1 polymorphism in the occurrence of CAD (AG vs. AA, OR: 1.08, p=0.635; GG vs. AA, OR: 0.62, p=0.220). Adjustment for confounding factors gave similar results, irrespective of the type of disease (i.e., stable coronary artery disease vs. acute coronary syndrome).


CONCLUSIONS
Our findings do not support the hypothesis that ROS1 rs529038 polymorphism is an important contributing factor in the etiology of CAD in the Greek population.
Theodoraki
Eirini V
EV
Department of Dietetics and Nutritional Science, Harokopio University of Athens, Athens, Greece. itheodoraki@gmail.com
Nikopensius
Tiit
T
Suhorutsenko
Julia
J
Papamikos
Vassileios
V
Kolovou
Genovefa D
GD
Peppes
Vassileios
V
Panagiotakos
Demosthenes
D
Limberi
Sasa
S
Zakopoulos
Nikolaos
N
Metspalu
Andres
A
Dedoussis
George V
GV
D000368:Aged; D001216:Asparagine / Q000235:genetics*; D001224:Aspartic Acid / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006115:Greece; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000235:genetics*
D011518:Proto-Oncogene Proteins; D001224:Aspartic Acid; D001216:Asparagine; D011505:Protein-Tyrosine Kinases; C062333:ROS1 protein, human