Quality assessment of the procedure for determination of heavy metals on reactive carriers.
Quality control and validity check of the solid-phase spectrophotometric procedure (Me-SPS) for determination of heavy metals important in pharmaceutical practice: zinc (Zn-SPS), lead (Pb-SPS), and cobalt (Co-SPS) were performed using a very simple and informative prevalidation concept. Further, metrological characteristics of the Me-SPS procedure together with the diagnosis of particular prevalidation steps were evaluated. Favourable prevalidation characteristics, i.e., ideal analytical function, homogeneity of data material, low limit of quantitation, and acceptable accuracy verified the quality of the Me-SPS procedure and pointed to the limitations of some investigated systems.
Vuković
Jadranka
J
Faculty of Pharmacy and Biochemistry, University of Zagreb, HR-10000 Zagreb, Croatia. jadranka@pharma.hr
Grdinić
Vladimir
V
Grubesić
Renata Jurisić
RJ
Zupanić
Ognjen
O
D000180:Acrylic Resins; D000465:Algorithms; D002852:Chromatography, Ion Exchange; D007202:Indicators and Reagents; D019216:Metals, Heavy / Q000032:analysis*; D011108:Polymers / Q000032:analysis; D011786:Quality Control; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet
D000180:Acrylic Resins; D007202:Indicators and Reagents; D019216:Metals, Heavy; D011108:Polymers