Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
Despite the existence of effective vaccines, HBV infection remains a major health problem with 2 billion people infected worldwide. Among them, 350 million are chronically infected, a major risk factor for the development of hepatocellular carcinoma (HCC). There is a strong need to develop new and efficient treatments against chronic infection and HCC. It is therefore important to understand HBV replication and persistence as well as the role of HBV in liver carcinogenesis. This chapter focuses on the regulatory protein HBx which is thought to play a central role in HBV regulation and pathogenesis. HBx has been shown to modulate a myriad of viral and cellular functions, yet its role in virus replication and pathogenesis in infected individuals remains far from being completely understood.
Benhenda
Shirine
S
Unité d'Oncogenèse et Virologie Moléculaire (INSERM U579), Institut Pasteur, 28 Rue du Dr. Roux, 75724 Paris Cedex 15, France.
Cougot
Delphine
D
Buendia
Marie-Annick
MA
Neuveut
Christine
C
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000821:virology; D004260:DNA Repair / Q000235:genetics; D015967:Gene Expression Regulation, Viral; D006515:Hepatitis B virus / Q000235:genetics / Q000254:growth & development* / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000821:virology; D008954:Models, Biological; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*; D054334:Viral Regulatory and Accessory Proteins; D014779:Virus Replication / Q000235:genetics / Q000502:physiology
D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein