Gd(DO3A-N-alpha-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents.
We report the synthesis of a novel, versatile and easily accessible metal chelator, DO3A-N-alpha-aminopropionate, and the relaxometric characterization of its Gd(3+) complex, revealing great potential for the development of high relaxivity targeted contrast agents for magnetic resonance imaging.
Centro de Química, Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.
Miguel F
MF
Ferreira
André F
AF
Martins
José A
JA
Martins
Paula M
PM
Ferreira
Eva
E
Tóth
Carlos F G C
CF
Geraldes
D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water / Q000737:chemistry*
D003287:Contrast Media; D009942:Organometallic Compounds; D014867:Water; D005682:Gadolinium