Results of surgical treatment for renovascular hypertension in children: 30 year single centre experience.
BACKGROUND
We retrospectively reviewed the medical records of all patients who underwent surgery as part of the treatment of renovascular hypertension (RVH) at our centre between 1979 and 2008. Patients. Thirty-seven children (65% male) with a median age of 7.6 (0.4-17.9) years were identified with a median systolic blood pressure (SBP) of 140 (105-300) mm Hg prior to surgery. Bilateral renal artery stenosis and intra-renal disease were present in 19 (51%) patients, mid-aortic syndrome in 15 (40%), involvement of visceral arteries in eight out of 35 (23%) and coexisting cerebral disease in eight out of 30 (26%) investigated patients.


RESULTS
Surgical procedures (n = 53) included (i) nephrectomy (18, of which two unplanned and two secondary due to technical failure), (ii) renovascular surgery on the renal arteries (28, of which 18 had autologous surgery and 10 synthetic grafts inserted for revascularisation) and (iii) aortic reconstruction with (6) and without (1) a synthetic graft. Post-operative complications were haemorrhage (5), septicaemia (5) and chylous ascites (1). There were no perioperative deaths; two children died during follow-up. The SBP post-surgery improved to a median value of 116 (range 90-160) mm Hg. Twelve months after surgery, 16 (43%) children had normal blood pressure without treatment, 15 (41%) normal or improved on one to four antihypertensive drugs and four (11%) unchanged; no data were available for two (5%) children.


CONCLUSIONS
Surgery effectively treated the hypertension of 90% of our children, when performed in conjunction with medical therapy and interventional radiology. In spite of aggressive surgical treatment, RVH is sometimes a progressive disease.
Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, UK.
Marike B
MB
Stadermann
Giovanni
G
Montini
George
G
Hamilton
Derek J
DJ
Roebuck
Clare A
CA
McLaren
Michael J
MJ
Dillon
Stephen D
SD
Marks
Kjell
K
Tullus
D000293:Adolescent; D001011:Aorta / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000601:surgery*; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D009392:Nephrectomy; D017063:Outcome Assessment, Health Care; D012077:Renal Artery / Q000601:surgery; D012189:Retrospective Studies; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures