STUDIES ON THE TOTAL BILE : IV. THE ENTEROHEPATIC CIRCULATION OF BILE PIGMENT.
In dogs fed the green bile or the liver tissue of herbivora, the bile later secreted frequently becomes green, changing from the previous yellow-brown. When they are fed sheep bile that contains cholohematin, their bile comes to contain this pigment. When they are fed dog bile in quantity a well marked increase in the output of bilirubin by the liver frequently follows. Taken together, these facts indicate the existence of an enterohepatic circulation of bile pigment.
Laboratories of The Rockefeller Institute for Medical Research.
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