REACTIONS OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI : III. A STUDY OF MODES OF SENSITIZATION.
The most satisfactory method thus far found for the induction and maintenance of a high degree of hypersensitiveness-"allergy," "hyperergy"-against non-hemolytic streptococci consists in the repeated production of small focal lesions with minimal doses of bacteria. After a preliminary sensitizing period of about 2 weeks' duration with either large initial, or small multiple daily inoculations, the later foci need be produced only at 7 to 10 day intervals. Chronicity of low-grade infection appears to be an important factor in the attainment of a high degree of hypersensitiveness.
Hospital of The Rockefeller Institute for Medical Research.
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Derick
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Hitchcock
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Swift