[Vesicoureteric reflux: it all depends on the genes?].
Vesicoureteric reflux (VUR) defined as reversed urine flow from the urinary bladder to ureter(s) and frequently to kidneys is associated with abnormal structure and/or malfunction of one or both ureterovesical junctions. In the pediatric practice, VUR constitutes an important problem not only because of prevalence but also because of the role it plays in pathogenesis of urinary tract infections, reflux nephropathy and chronic renal failure in children. Recent reports confirm genetic background of vesicoureteric reflux. Vesicoureteric reflux is inherited as a dominant autosomal disease (with possible incomplete gene(s) penetration). The Authors present a review of recent literature with focus on key role of candidate genes in the development of VUR in children.
Klinika Pediatrii, Hematologii i Onkologii Dzieciecej Pomorskiej Akademii Medycznej w Szczecinie, Szczecin.
Andrzej
A
Brodkiewicz
Anna
A
Zakowska
Agnieszka
A
Bińczak-Kuleta
Jarosław
J
Peregud-Pogorzelski
Andrzej
A
Ciechanowicz
D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D014718:Vesico-Ureteral Reflux / Q000235:genetics*