From DNA to blood groups.
A blood group antigen is a protein or carbohydrate on the outer surface of a RBC. Portions of DNA are transcribed and translated into proteins. A protein-based blood group antigen is the direct product of a gene whereas a carbohydrate-based blood group antigen is an indirect product of a gene; the gene product is a glycosyltransferase that transfers a carbohydrate moiety to a protein, or to another carbohydrate to form a chain of sugars. This report gives a brief description of a gene, its processing from DNA through RNA to an amino acid sequence, and how changes in nucleotides give rise to blood group antigens.
Reid
M E
ME
New York Blood Center, New York, NY 10065, USA.
D001789:Blood Group Antigens / Q000096:biosynthesis* / Q000235:genetics*; D002241:Carbohydrates / Q000096:biosynthesis / Q000235:genetics; D004247:DNA / Q000235:genetics; D005091:Exons / Q000235:genetics; D016695:Glycosyltransferases / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D016254:Mutagenesis, Insertional; D017384:Sequence Deletion
D001789:Blood Group Antigens; D002241:Carbohydrates; D004247:DNA; D016695:Glycosyltransferases