Relationship between high-sensitivity C-reactive protein and clinical functional outcome after acute ischemic stroke in a Korean population.
BACKGROUND
High-sensitivity C-reactive protein (hs-CRP) has been shown to be a powerful predictor of coronary ischemic events. However, the prognosis of functional disability in patients with cerebrovascular disease has not been well established. Therefore, we performed this study to determine the prognostic significance of hs-CRP levels in patients with functional disability after acute ischemic stroke.


METHODS
A total of 417 Korean patients with ischemic stroke were examined within 24 h after symptom onset. hs-CRP measurements were obtained on admission and on the seventh hospital day. The correlations between the concentration of hs-CRP and functional disability duration 12 months after stroke onset were analyzed.


RESULTS
The present study showed that hs-CRP levels on admission and on the seventh hospital day were significantly correlated with the modified Rankin Scale (mRS) score 12 months after stroke onset. These results also demonstrated that mRS scores are more closely associated with hs-CRP levels on the seventh hospital day than hs-CRP levels on admission.


CONCLUSIONS
This study demonstrated that elevated hs-CRP levels on the seventh hospital day, rather than within 24 h after stroke onset, could strongly predict the prognosis of functional disability. These results supported that hs-CRP is a useful marker of ischemic stroke in the Korean population.
Song
In-Uk
IU
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Kim
Joong-Seok
JS
Kim
Yeong-In
YI
Lee
Kwang-Soo
KS
Jeong
Du-Shin
DS
Chung
Sung-Woo
SW
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000175:diagnosis* / Q000208:ethnology
D015415:Biomarkers; D002097:C-Reactive Protein