[Effector function plasticity of T helper lymphocytes].
T helper (Th) cells are grouped into functionally different subsets (considered hitherto distinct and stable) according to their cytokine production. However, a number of recent findings show a much higher degree of Th cell plasticity and interconvertibility than previously assumed. Therefore, Th effector functions might be subject to therapeutic modulation even in late stages of immunopathological diseases.
Institut für Immunologie, Universitätsklinikum Jena, Leutragraben 3, 07740, Jena, Deutschland. oliver.frey@mti.uni-jena.de
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D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D016207:Cytokines / Q000097:blood*; D044127:Epigenesis, Genetic / Q000235:genetics / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology; D007125:Immunogenetics; D016130:Immunophenotyping; D007249:Inflammation / Q000276:immunology; D007376:Interleukin-2 / Q000502:physiology; D015847:Interleukin-4 / Q000502:physiology; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014157:Transcription Factors / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000502:physiology
D016207:Cytokines; D007376:Interleukin-2; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D015847:Interleukin-4