Preparation and characterization of vitamin-12 loaded biodegradable pH-sensitive microgels.
This paper prepared novel biodegradable and pH-sensitive microgels based on Poly(epsilon-caprolactone)-Pluronic-Poly(epsilon-caprolactone)-dimethacrylate (PCFC-DMA), Poly(ethylene glycol) dimethacrylate (PEG-DMA) and methylacrylic acid (MAA) cross-linked with N,N'-methylenebisacrylamide (BIS), initiated by NaHSO(3), K(2)S(2)O(8). The blank microgels were prepared by inversed-phase suspension polymerization method and pH sensitivity of microgels was characterized. Then the blank microgels were loaded with hydrophilic model drug vitamin-12 (VB-12) and in vitro drug release behaviour was also studied here.
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Chengdu, PR China.
Xu
X
Xu
ShaoZhi
S
Fu
Ke
K
Wang
WenJuan
W
Jia
Gang
G
Guo
XiuLing
X
Zheng
PengWei
P
Dong
QingFa
Q
Guo
ZhiYong
Z
Qian
D005782:Gels; D006863:Hydrogen-Ion Concentration; D008689:Methacrylates / Q000737:chemistry*; D011060:Poloxalene / Q000031:analogs & derivatives* / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D014805:Vitamin B 12 / Q000008:administration & dosage*
D005782:Gels; D008689:Methacrylates; D011091:Polyesters; C547086:poly(epsilon-caprolactone)-pluronic-poly(epsilon-caprolactone)-dimethacrylate; C421283:poly(ethylene glycol)-dimethacrylate; D011092:Polyethylene Glycols; D011060:Poloxalene; D014805:Vitamin B 12