Insulin sensitivity in prepubertal Caucasian normal weight children.
BACKGROUND
Determining whether or not a child is insulin resistant is becoming a matter of fundamental interest even in childhood, as the incidence of metabolic complications of insulin resistance is rising. Thus reference values are needed.


OBJECTIVE
To set percentiles for HOMA-IR and WBISI in Caucasian normal weight prepubertal children.


METHODS
238 normal weight prepubertal Caucasian children (126 males/112 females).


METHODS
After physical examination including anthropometric measurements all children underwent an oral glucose tolerance test from which HOMA-IR and WBISI were calculated.


RESULTS
HOMA-IR values above the 95th percentile (2.03) and WBISI values below the 5th percentile (5.67) represent the cut-off values for the determination of insulin resistance.


CONCLUSIONS
These reference values are useful to easily detect insulin resistance within the prepubertal Caucasian population representing a helpful tool for clinicians to target such children in order to improve insulin sensitivity.
Department of Pediatrics, University of Chieti, Chieti, Italy.
Fabio G
FG
Masuccio
Franca M
FM
Lattanzio
Sabino
S
Matera
Cosimo
C
Giannini
Francesco
F
Chiarelli
Angelika
A
Mohn
D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002648:Child; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000208:ethnology*; D007558:Italy / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis; D012016:Reference Values; D044465:White People / Q000208:ethnology*
D001786:Blood Glucose; D007328:Insulin