[3,3]-Sigmatropic rearrangements: recent applications in the total synthesis of natural products.
Among the fundamental chemical transformations in organic synthesis, the [3,3]-sigmatropic rearrangement occupies a unique position as a powerful, reliable, and well-defined method for the stereoselective construction of carbon-carbon or carbon-heteroatom bonds. While many other reactions can unite two subunits and create a new bond, the strengths of sigmatropic rearrangements derive from their ability to enable structural reorganization with unmatched build-up of complexity. Recent applications that illustrate [3,3]-sigmatropic processes as a key concept in the synthesis of complex natural products are described in this tutorial review, covering literature from about 2001 through early 2009.
Ilardi
Elizabeth A
EA
Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, CA 93106, USA.
Stivala
Craig E
CE
Zakarian
Armen
A
D001688:Biological Products / Q000138:chemical synthesis*; D008722:Methods; D055601:Organic Chemistry Phenomena; D013237:Stereoisomerism
D001688:Biological Products