Endoscopic transsphenoidal surgery for isolated fibrous dysplasia of the clivus.
BACKGROUND
Fibrous dysplasia is a non-neoplastic disorder of bone, related to abnormal proliferation of fibro-blasts.


METHODS
We report a 41-year-old female who presented with hyperprolactinaemia and an incidental clival lesion on MR scan. This was sub-totally resected via an endoscopic transsphenoidal approach and fibrous dysplasia was confirmed histologically. Her postoperative re-covery was un-eventful and at 8 months follow-up, she remains well, other than for the intermittent headaches and with no pituitary hormone deficiencies.


CONCLUSIONS
The present case highlights the need to consider fibrous dysplasia in the differential diagnosis of isolated clival lesions.
Department of Neurosurgery, Greater Manchester Neurosciences Centre, Salford Royal Hospital, Manchester, UK.
N
N
Singh
A
A
Abou-Zeid
A
A
King
D
D
du Plessis
K
K
Gnanalingham
D000328:Adult; D003388:Cranial Fossa, Posterior / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D003399:Craniotomy / Q000295:instrumentation / Q000379:methods*; D004724:Endoscopy / Q000379:methods*; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D006801:Humans; D006966:Hyperprolactinemia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D010902:Pituitary Gland / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D011183:Postoperative Complications / Q000517:prevention & control; D011859:Radiography; D013100:Sphenoid Bone / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome