Taste masking of Etoricoxib by using ion-exchange resin.
The present study was carried out in order to mask the bitter taste of the Etoricoxib by complexation with cation-exchange resin, Indion 204. The drug resin complexes (DRC) were prepared by batch process and efficient drug loading was obtained by using inactivated form of resin in the drug-resin ratio 1:3.3 with 30 min swelling time of resin in 25 mL of water with 5 min stirring time. Drug-resin complexes were characterized for dissolution studies and spectral studies. Drug release from drug-resin complex in salivary pH was insufficient to impart bitter taste. Volunteers rated the drug resin complex as tasteless and agreeable.
Patra
Sradhanjali
S
University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar, Orissa, India. sradhanjali2002@yahoo.co.in
Samantaray
Rakesh
R
Pattnaik
Saswat
S
Barik
B B
BB
D000284:Administration, Oral; D002411:Cation Exchange Resins; D002626:Chemistry, Pharmaceutical; D052246:Cyclooxygenase 2 Inhibitors / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers; D004339:Drug Compounding; D000077613:Etoricoxib; D006801:Humans; D011725:Pyridines / Q000008:administration & dosage* / Q000737:chemistry; D013450:Sulfones / Q000008:administration & dosage* / Q000737:chemistry; D013649:Taste
D002411:Cation Exchange Resins; D052246:Cyclooxygenase 2 Inhibitors; D004337:Drug Carriers; D011725:Pyridines; D013450:Sulfones; D000077613:Etoricoxib