Unusual case of plasmablastic non-Hodgkin's lymphoma located in the liver. First case reported in an AIDS patient.
Plasmablastic lymphoma is a rare and a relatively new entity that was first described in the jaws and the oral cavity of HIV-AIDS patients. We report a case of plasmablastic lymphoma involving the liver in an AIDS patient. Plasmablastic lymphoma is considered a diffuse large B-cell lymphoma with a unique phenotype and predilection for the oral cavity. The case presented had a unique hepatic lesion, localized in the left lobe of the liver. Diagnosis was confirmed by hepatic biopsy guided by Computerized Tomography scan and histopathology. The smears showed a dense infiltrate composed by atypical lymphocytes with numerous plasmocytes expressing the plasma cell markers MUM-1 and CD138 and negative for the B-cell markers CD3, CD20 and CD45. Immunohistochemical and in situ hybridization revealed the Epstein-Barr virus genome in the atypical cells. Polymerase chain reaction was negative for HHV-8 RNA.
Metta
Humberto
H
HIV/AIDS Division, Infectious Diseases F. J. Muñiz Hospital, Buenos Aires, Argentina. hmetta@sinectis.com.ar
Corti
Marcelo
M
Maranzana
Aldo
A
Schtirbu
Ricardo
R
Narbaitz
Marina
M
De Dios Soler
Marcela
M
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D001706:Biopsy; D006801:Humans; D050835:Interferon Regulatory Factors / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology; D053668:Syndecan-1 / Q000378:metabolism; D000099218:Interferon Regulatory Factor-4
D050835:Interferon Regulatory Factors; D053668:Syndecan-1; D000099218:Interferon Regulatory Factor-4