Further Daphniphyllum alkaloids with insecticidal activity from the bark of Daphniphyllum macropodum M(IQ).
Two new Daphniphyllum alkaloids, macropodumines J and K (1 and 2, resp.), together with six known structurally related alkaloids, 3-8, were isolated from the bark of Daphniphyllum macropodum M(IQ). The structures of the new compounds 1 and 2 were elucidated on the basis of a comprehensive analysis of their spectroscopic and chemical data. Macropodumine J (1) contains a CN group which is relatively rare in naturally occurring alkaloids. All isolated compounds were tested for their insecticidal activities against a number of insect species. Daphtenidine C (5) is the most active compound against Plutella xylostella. This is the first report of insecticidal properties of Daphniphyllum alkaloids.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, PR China.
Zhen-Yu
ZY
Li
Yu-Cheng
YC
Gu
Dianne
D
Irwin
Jacqueline
J
Sheridan
John
J
Clough
Ping
P
Chen
Shu-Ying
SY
Peng
Yi-Ming
YM
Yang
Yue-Wei
YW
Guo
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002845:Chromatography; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007915:Lepidoptera / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D031995:Saxifragaceae / Q000737:chemistry*; D013057:Spectrum Analysis
D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D007306:Insecticides; D010936:Plant Extracts