The Mayo Dysphagia Questionnaire-30: documentation of reliability and validity of a tool for interventional trials in adults with esophageal disease.
The aim of this study was to develop the Mayo Dysphagia Questionnaire-30 Day (MDQ-30), a tool to measure esophageal dysphagia, by adapting items from validated instruments for use in clinical trials, and assess its feasibility, reproducibility, and concurrent validity. Outpatients referred to endoscopy for dysphagia or seen in a specialty clinic were recruited. Feasibility testing was done to identify problematic items. Reproducibility was measured by test-retest format. Concurrent validity reflects agreement between information gathered in a structured interview versus the patients' written responses. The MDQ-30, a 28-item instrument, took 10 min (range = 5-30 min) to complete. Four hundred thirty-one outpatients [210 (49%) men; mean age = 61 years] participated. Overall, most concurrent validity kappa values for dysphagia were very good to excellent with a median of 0.78 (min 0.28, max 0.95). The majority of reproducibility kappa values for dysphagia were moderate to excellent with a median kappa value of 0.66 (min 0.07, max 1.0). Overall, concurrent validity and reproducibility kappa values for gastroesophageal reflux disease (GERD) symptoms were 0.81 (95% CI = 0.72, 0.91) and 0.66 (95% CI = 0.55, 0.77), respectively. Individual item percent agreement was generally very good to excellent. Internal consistency was excellent. We conclude that the MDQ-30 is an easy-to-complete tool to evaluate reliably dysphagia symptoms over the last 30 days.
Mayo Medical School, Mayo Clinic, Rochester, MN 55905, USA.
Judith
J
McElhiney
Matthew R
MR
Lohse
Amindra S
AS
Arora
Joanna M
JM
Peloquin
Debra M
DM
Geno
Melissa M
MM
Kuntz
Felicity B
FB
Enders
Mary
M
Fredericksen
Adil A
AA
Abdalla
Yulia
Y
Khan
Nicholas J
NJ
Talley
Nancy N
NN
Diehl
Timothy J
TJ
Beebe
Ann M
AM
Harris
Gianrico
G
Farrugia
Darlene E
DE
Graner
Joseph A
JA
Murray
G Richard
GR
Locke
Rayna M
RM
Grothe
Michael D
MD
Crowell
Dawn L
DL
Francis
April M B
AM
Grudell
Tushar
T
Dabade
Angelica
A
Ramirez
MhdMaan
M
Alkhatib
Jeffrey A
JA
Alexander
Jessica
J
Kimber
Ganapathy
G
Prasad
Alan R
AR
Zinsmeister
Yvonne
Y
Romero
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016001:Confidence Intervals; D003679:Deglutition; D003680:Deglutition Disorders / Q000175:diagnosis* / Q000188:drug therapy; D004935:Esophageal Diseases / Q000175:diagnosis / Q000188:drug therapy; D005240:Feasibility Studies; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D015203:Reproducibility of Results; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult