A one-pot approach to neoglycopeptides using orthogonal native chemical ligation and click chemistry.
The powerful combination of native chemical ligation and click chemistry has been used to affect a one-pot synthesis of neoglycopeptides from propargyl-containing peptides using GalNAc-N(3) as the glycan component. A versatile chemical toolkit for the fully convergent synthesis of neoglycoproteins using click chemistry, native chemical ligation, and kinetically controlled ligation is thus demonstrated.
Lee
Dong Jun
DJ
Department of Chemistry, The University of Auckland, 23 Symonds Street, Auckland, New Zealand.
Mandal
Kalyaneswar
K
Harris
Paul W R
PW
Brimble
Margaret A
MA
Kent
Stephen B H
SB
D020650:Combinatorial Chemistry Techniques; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D007700:Kinetics; D008024:Ligands; D015394:Molecular Structure; D013237:Stereoisomerism
D006020:Glycopeptides; D008024:Ligands