[Is there a correlation between S100 beta and post-concussion symptoms after mild traumatic brain injury?].
In the past a lot of patients suffered from post-concussive symptoms (PCS) after mild traumatic brain injury (mTBI). The present prospective study (n = 73) was intended to help predict the outcome after mTBI with blood asservation for analysis of S100 beta 3 hours after trauma. There was no statistically significant correlation be-tween PCS or even of single symptoms and elevated marker levels. Serum S100 beta appears to be a poor predictor of the outcome following mild TBI. Establishing a diagnosis of "PCS" will still be hard in future, since no objective diagnostic -method exists. The most important facts are a precise examination and a history of the patient with a negative CT scan of the head.
Kleinert
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K
Spital Oberengadin, Unfallchirurgische Klinik, CH-7503 Samedan, Schweiz. kathi-KK@web.de
Schleich
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F
Biasca
N
N
Simmen
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HP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000000981:diagnostic imaging; D001924:Brain Concussion / Q000097:blood* / Q000175:diagnosis*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D009460:Neurologic Examination; D038223:Post-Concussion Syndrome / Q000097:blood* / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D013223:Statistics as Topic; D014057:Tomography, X-Ray Computed; D055815:Young Adult
D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human