Overweight patients with severe sleep apnea experience deeper oxygen desaturation at apneic events.
We investigated differences in the depth of hypoxia produced by apneic events of the same duration (30 seconds) amongst patients with different degrees of OSAS according to their AIs (apnea indices). The relationship between apnea duration (seconds) and fall in oxygen saturation (%) was evaluated by means of a linear regression analysis. The fall induced by a 30-second apnea event was designated as the "oxygen desaturation value 30" (ODV30). We analyzed the polysomnographic recordings of 122 OSAS patients who showed significant correlations (p<0.01) between apnea duration and subsequent fall in oxygen saturation and calculated their respective ODV30. We evaluated the influence of AI and BMI on ODV30 by multi-comparison and found out that standardized partial regression coefficients of BMI and AI were 0.578 and 0.148, respectively (multi-regression analysis, SPSS). BMI was proved to be more influential on ODV30 than AI was. On the other hand, the ODV30 of mild, moderate and severe OSAS patients was 8.84 +/- 2.62% (Mean +/- S.D.), 8.25 +/- 2.45% and 10.59 +/- 3.32%, respectively. Our study shows that fall in oxygen saturation is particularly extensive in severe OSAS patients and that fall in oxygen saturation is deepened as obesity increases. We think ODV30 is a useful variable for evaluating OSAS.
Department of Sleep-Related Respiratory Disorders, Tokyo Medical and Dental University Graduate School, Japan. mitsuo.gend@tmd.ac.jp
Mitsuo
M
Sato
Masaaki
M
Suzuki
Jun-ichi
J
Suzuki
Yuri
Y
Endo
Yoshiaki
Y
Chiba
Masato
M
Matsuura
Kenzo
K
Nakagawa
Shiro
S
Mataki
Norimasa
N
Kurosaki
Makoto
M
Hasegawa
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D009202:Cardiomyopathies / Q000209:etiology; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000209:etiology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000150:complications / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000145:classification / Q000150:complications / Q000503:physiopathology*; D055815:Young Adult
D010100:Oxygen