Responses of human medial temporal lobe neurons are modulated by stimulus repetition.
Recent studies have reported the presence of single neurons with strong responses to visual inputs in the human medial temporal lobe. Here we show how repeated stimulus presentation--photos of celebrities and familiar individuals, landmark buildings, animals, and objects--modulates the firing rate of these cells: a consistent decrease in the neural activity was registered as images were repeatedly shown during experimental sessions. The effect of repeated stimulus presentation was not the same for all medial temporal lobe areas. These findings are consistent with the view that medial temporal lobe neurons link visual percepts to declarative memory.
Department of Engineering, University of Leicester, Leicester, UK.
Carlos
C
Pedreira
Florian
F
Mormann
Alexander
A
Kraskov
Moran
M
Cerf
Itzhak
I
Fried
Christof
C
Koch
Rodrigo Quian
RQ
Quiroga
D000200:Action Potentials; D000222:Adaptation, Physiological / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D004567:Electrodes, Implanted; D004827:Epilepsy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000502:physiology*; D010775:Photic Stimulation; D013702:Temporal Lobe / Q000502:physiology*; D013997:Time Factors; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult