Regulation of p27(kip1) mRNA expression by microRNAs.
p27(kip1) (p27) is a cell cycle inhibitor and tumor suppressor whose expression is highly regulated in the cell. Low levels of p27 have been associated with poor prognosis in cancer. Recently, several microRNAs have been described to control p27 expression in various tumor types. In this chapter, we will provide an overview on the role of microRNAs in cancer, and will discuss how microRNAs regulate p27 expression and the implications for tumor progression.
Centre de Regulació Genòmica (CRG-UPF), Gene Regulation Programme, Dr Aiguader 88, 08003, Barcelona, Spain.
Aida
A
Martínez-Sánchez
Fátima
F
Gebauer
D000818:Animals; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000235:genetics* / Q000378:metabolism; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
D035683:MicroRNAs; D012333:RNA, Messenger; D050760:Cyclin-Dependent Kinase Inhibitor p27