In vivo antiparasitic activity of the Thai traditional medicine plant--Tinospora crispa--against Plasmodium yoelii.
We investigated the in vivo antimalarial effect of crude extract of Tinospora crispa, a Thai traditional medicine plant. Mice were inoculated with Plasmodium yoelii then treated with the crude extract of Tinospora crispa at doses of 20, 40 and 80 mg/kg. Mice receiving the dose of 20 mg/kg died on average on Day 8. Mice remained alive longer when treated of the dose of 40 mg/kg or even longer under the treatment of the dose of 80 mg/kg. Surprisingly and interestingly, one mouse from the group in which the dose of 80 mg/kg was administrated is still alive and the parasite was cleared from the blood stream. In conclusion, T. crispa has an in vivo antimalarial effect in dose dependent manner.
Department of Anatomy, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. sitrr@mahidol.ac.th
Thanaporn
T
Rungruang
Thidarut
T
Boonmars
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000494:pharmacology*; D010967:Plasmodium yoelii / Q000187:drug effects*; D013785:Thailand; D031610:Tinospora
D000962:Antimalarials; D010936:Plant Extracts