Adenovirus DNA positivity in nasopharyngeal aspirate preceding hematopoietic stem cell transplantation: a very strong risk factor for adenovirus DNAemia in pediatric patients.
Human adenovirus (HAdV)-positive nasopharyngeal aspirate preceding hematopoietic stem cell transplantation was prospectively analyzed in 62 patients. By multivariate Cox proportional hazard models, HAdV-positive nasopharyngeal aspirate was the only predictor for HAdV DNAemia after hematopoietic stem cell transplantation (P < .001). HAdV DNAemia was a predictor for alloreactive disease. Early detection and intervention might help to prevent HAdV disease after hematopoietic stem cell transplantation.
Department of Pediatric Immunology and Hematology, Wilhelmina Children's Hospital Utrecht, Utrecht, the Netherlands.
Anne P J
AP
de Pagter
Lianne M
LM
Haveman
Rob
R
Schuurman
Martin
M
Schutten
Marc
M
Bierings
Jaap-Jan
JJ
Boelens
D000257:Adenoviridae Infections / Q000453:epidemiology* / Q000821:virology; D000260:Adenoviruses, Human / Q000302:isolation & purification*; D000293:Adolescent; D002353:Carrier State / Q000453:epidemiology* / Q000821:virology; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009305:Nasopharynx / Q000821:virology*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D014766:Viremia / Q000453:epidemiology* / Q000821:virology; D055815:Young Adult
D004279:DNA, Viral