Ytterbium(III) triflate catalyzed tandem Friedel-Crafts alkylation/hydroarylation of propargylic alcohols with phenols as an expedient route to indenols.
A method to prepare indenols efficiently by ytterbium(III) triflate catalyzed tandem Friedel-Crafts alkylation/hydroarylation of propargylic alcohols with phenols is described. The reaction was accomplished in moderate to excellent yields and regioselectivity under mild conditions and offers a straightforward and convenient one step synthetic route to bioactive indenols and its derivatives.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637616, Singapore.
Xiaoxiang
X
Zhang
Wan Teng
WT
Teo
Philip Wai Hong
PW
Chan
D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry; D011412:Propanolamines / Q000138:chemical synthesis* / Q000737:chemistry; D020005:Propanols / Q000737:chemistry*; D015018:Ytterbium / Q000737:chemistry*
D000438:Alcohols; D000480:Alkynes; D007192:Indenes; D008698:Mesylates; D010636:Phenols; D011412:Propanolamines; D020005:Propanols; C002989:indenolol; C028255:propargyl alcohol; D015018:Ytterbium