The steady-state phase distribution of the motor switch complex model of Halobacterium salinarum.
Steady-state analysis is performed on the kinetic model for the switch complex of the flagellar motor of Halobacterium salinarum (Nutsch et al.). The existence and uniqueness of a positive steady-state of the system is established and it is demonstrated why the steady-state is centered around the competent phase, a state of the motor in which it is able to respond to light stimuli. It is also demonstrated why the steady-state shifts to the refractory phase when the steady-state value of the response regulator CheYP increases. This work is one aspect of modeling in systems biology wherein the mathematical properties of a model are established.
Max Planck Institute of Biochemistry, Department of Membrane Biochemistry, 82152 Martinsried, Germany.
Ricardo C H
RC
del Rosario
Francine
F
Diener
Marc
M
Diener
Dieter
D
Oesterhelt
D000465:Algorithms; D001426:Bacterial Proteins / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D003198:Computer Simulation; D005407:Flagella / Q000502:physiology*; D019617:Halobacterium salinarum / Q000502:physiology*; D007700:Kinetics; D016014:Linear Models; D008565:Membrane Proteins / Q000502:physiology*; D000072236:Methyl-Accepting Chemotaxis Proteins; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000502:physiology*; D017711:Nonlinear Dynamics; D015398:Signal Transduction / Q000502:physiology; D049490:Systems Biology / Q000379:methods
D001426:Bacterial Proteins; D008565:Membrane Proteins; D000072236:Methyl-Accepting Chemotaxis Proteins; D020409:Molecular Motor Proteins