Can serial eGFR, body mass index and smoking predict renal allograft survival in south Asian patients.
Limited data exist regarding long-term allograft survival in South Asian patients in the era of modern immunosuppressive therapy. This retrospective cohort study was undertaken to see the graft survival based on serial eGFR, immunosuppressive therapy, BMI and other confounding factors including smoking in patients who have undergone renal transplantation in a tertiary care center in south India. Three hundred and three kidney transplant recipients including live and cadaveric transplantation performed between 2001 and 2006 were included in this study. The mean graft survival after transplantation was 6.38 +/- 0.11 years, graft survival at one, two, three and five years were 95.7%, 92.72%, 91.72% and 89.21%, respectively. The mean serum creatinine and eGFR in the biopsy proven acute rejection (BPAR) group were 1.74 +/- 0.94 mg/dL and 43.73 +/- 13.65 mL/min com-pared with 1.24 +/- 0.59 mg/ dL and 61.50 +/- 17.40 mL/min in the non-BPAR group (P < 0.001 and P= 0.0159) respectively. The mean BMI in the BPAR group at one year was 26.59 +/- 3.18 kg/m 2 compared with 21.63 +/- 2.29 kg/m 2 in the non-BPAR group (P < 0.05). The mean graft survival in patients who were smokers at the time of pretransplant evaluation was 89.3% compared with 92.5% in the non-smokers (P=0.347). This retrospective cohort study found that serial eGFR, body mass index and smoking were significant predictors of graft survival following renal transplantation in South Asian patients.
Pondicherry Institute of Medical Sciences, Puducherry, Madras Medical Mission, Chennai, India.
Asik Ali
AA
Mohamed Ali
Georgi
G
Abraham
Milly
M
Mathew
Nusrath
N
Fathima
Saravanan
S
Sundararaj
Varun
V
Sundaram
Nancy
N
Lesley
D000328:Adult; D000367:Age Factors; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000208:ethnology / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007194:India; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000208:ethnology; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000208:ethnology; D013997:Time Factors; D014184:Transplantation, Homologous
D015415:Biomarkers; D007166:Immunosuppressive Agents; D003404:Creatinine