The role of mitochondrial proteins in sperm capacitation.
Spermatozoa deposited in the female reproductive tract need to undergo a multifaceted maturation process prior to fertilization termed "capacitation". This process is regulated by several proteins which are compartmentalized in discrete domains of the spermatozoon including the head, the mid-piece and the principal piece. Over the last decade many proteins involved in capacitation have been identified, such as proteins involved in the organization of the tail, proteins involved in signal transduction, chaperones, ion-channel proteins and mitochondria-associated proteins. This review focuses on the identity and function of mitochondrial proteins which undergo capacitation-dependent tyrosine phosphorylation in spermatozoa.
Shivaji
S
S
Centre for Cellular and Molecular Biology, Hyderabad, India. shivas@ccmb.res.in
Kota
Venkatesh
V
Siva
Archana B
AB
D020101:Acrosome Reaction; D000818:Animals; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000517:prevention & control; D008297:Male; D024101:Mitochondrial Proteins / Q000502:physiology*; D010766:Phosphorylation; D015398:Signal Transduction; D013075:Sperm Capacitation; D013094:Spermatozoa / Q000378:metabolism* / Q000648:ultrastructure
D024101:Mitochondrial Proteins