Zinc chloride-promoted aryl bromide-alkyne cross-coupling reactions at room temperature.
Substoichiometric amounts of ZnCl(2) promote the room temperature, Pd/P(t-Bu)(3)-catalyzed cross-coupling of aryl bromides with alkynes. Pd(I) dimer 1 is demonstrated to be a particularly active precatalyst for this reaction. The reaction is general for a wide variety of aryl bromides.
Department of Chemistry, University of Illinois Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.
Aaron D
AD
Finke
Eric C
EC
Elleby
Michael J
MJ
Boyd
Haim
H
Weissman
Jeffrey S
JS
Moore
D000480:Alkynes / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013696:Temperature; D017967:Zinc Compounds / Q000737:chemistry*
D000480:Alkynes; D002712:Chlorides; D006842:Hydrocarbons, Brominated; D017967:Zinc Compounds; C016837:zinc chloride