Fulminant liver failure in a patient affected by polycystic liver disease and liver metastases from breast carcinoma.
BACKGROUND
Polycystic liver disease (PLD) is a rare, congenital, benign condition characterized by the presence of multiple bile-duct-derived epithelial cysts in the liver parenchyma. The disease is usually asymptomatic, but cyst growth can result in complications such as ascites, esophageal varices, jaundice and hepatic failure. The exact mechanism leading to cyst growth is unclear, but estrogenic stimulation and paracrine action of vascular endothelial growth factor (VEGF) are thought to play a role in the growth of cyst epithelium.


METHODS
We report a case of acute liver failure in a young woman with PLD and liver metastases from breast carcinoma.


RESULTS
No data are available in the literature about metastatic liver involvement in PLD patients affected by breast cancer. The prognosis of patients with liver metastases is generally poor but fulminant liver failure is a very rare occurrence. Estrogen stimulation seems to be a risk factor for breast cancer and severe PLD. In the reported case, the presence of either the cysts or the metastatic lesions may have resulted in more extensive liver damage.


CONCLUSIONS
The adoption of drugs selected in relation to their hepatic toxicity together with careful monitoring of liver function is warranted in the management of breast cancer patients affected by PLD, in order to reduce the risk of liver failure.
Fadda
Giovanni Maria
GM
Oncologia Medica, University of Sassari, Sassari, Italy.
Santeufemia
Davide Adriano
DA
Cossu-Rocca
Paolo
P
Bardino
Gianfranco
G
Costantino
Salvatore
S
Sanna
Giovanni
G
Sarobba
Maria Giuseppa
MG
Farris
Antonio
A
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000503:physiopathology / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D003560:Cysts / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000503:physiopathology; D017114:Liver Failure, Acute / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D008113:Liver Neoplasms / Q000503:physiopathology / Q000556:secondary*; D008408:Mastectomy; D011878:Radiotherapy
D000970:Antineoplastic Agents