Antibacterial clerodane diterpenes from Goldenrod (Solidago virgaurea).
Nine clerodane diterpenes, solidagoic acids C-I (1-7), cleroda-3,13(14)-dien-16,15:18,19-diolide (8) and cleroda-3,13(14)-dien-15,16:18,19-diolide (9) were isolated and characterised from the ethanol-ethyl acetate (1:1) extract of Solidago virgaurea. The structures were determined by NMR spectroscopic analysis. Several displayed moderate antibacterial activity against Staphylococcus aureus.
Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences Inc., 1912 Innerbelt Business Center Drive, St. Louis, MO 63114, USA. cstarks@sequoiasciences.com
Courtney M
CM
Starks
Russell B
RB
Williams
Matt G
MG
Goering
Mark
M
O'Neil-Johnson
Vanessa L
VL
Norman
Jin-Feng
JF
Hu
Eliane
E
Garo
Grayson W
GW
Hough
Stephanie M
SM
Rice
Gary R
GR
Eldridge
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D036624:Solidago / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D010936:Plant Extracts