[Effect of danhong injection on platelet activation and inflammatory factors in patients of acute coronary syndrome after intervention therapy].
OBJECTIVE
To explore the effect of Danhong Injection (DHI) on platelet activation and inflammatory factors in patients of acute coronary syndrome (ACS) after intervention therapy.


METHODS
One hundred ACS patients were randomly assigned to the DHI group and the control group equally. Both were treated with the conventional treatment, including aspirin, clopidogrel, beta-receptor blocker, angiotensin converting enzyme inhibitor, etc. for 2 weeks after percutaneous coronary intervention (PCI), and to the patients in the DHI group, intravenous dripping of DHI was given simultaneously. Fasting venous blood of patients were collected before PCI and on the next morning of PCI to determine the platelet activation indices, expression of CD62p and receptor complex of glucose protein (GP) II b/III a by flow cytometry; plasma fibrinogen C (FIB-C) by scattering turbidimetry, and serum high-sensitivity C-reactive protein (hs-CRP) with emulsoid immuno-enhancing turbidimetric test kit. The outcomes were compared with those determined in 40 healthy persons for control.


RESULTS
Serum levels of CD62p, GP II b/III a, FIB-C and hs-CRP in ACS patients were significantly higher than those in the healthy control (all P<0.01), and those were significantly higher after PCI than before PCI (P <0.05 or P<0.01). After being treated for 2 weeks, the 4 platelet activation indices were lowered to different extent in both groups, but the lowering in the DHI group was more significant than that in the control group (P<0.05).


CONCLUSIONS
DHI can inhibit the platelet activation and inflammatory reaction in ACS patients after PCI.
Chen
Zhang-Qiang
ZQ
Department of Cardiology, Jiangxi Provincial People's Hospital, Nanchang. chenzq888@163.com
Hong
Lang
L
Wang
Hong
H
D054058:Acute Coronary Syndrome / Q000378:metabolism* / Q000628:therapy*; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D015539:Platelet Activation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D019007:P-Selectin; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; C540581:danhong; D005340:Fibrinogen