[Ser49gly polymorphism as predictor of development of hereditary sick sinus node syndrome].
We demonstrated for the first time on clinico-genetic material an association of hereditary sick sinus node syndrome (SSNS) with polymorphism of beta-adrenorecetor gene. We found that heterozygous variant of Ser49gly of beta-adrenoreceptor gene was significantly more often met in patients with SSNS and their healthy relatives than in subjects of control group. In the group of patients with SSNS contrary to control group we noted statistically significant preponderance of carriers of mutant Gly49 allele of.
Nikulina
S Iu
SIu
Shul'man
V A
VA
Chernova
A A
AA
Voevoda
M I
MI
Maksimov
V N
VN
Kazarinova
Iu L
IuL
D000328:Adult; D000483:Alleles; D004247:DNA / Q000235:genetics*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011379:Prognosis; D011446:Prospective Studies; D018342:Receptors, Adrenergic, beta-1 / Q000097:blood / Q000235:genetics*; D012804:Sick Sinus Syndrome / Q000097:blood / Q000175:diagnosis / Q000235:genetics*
D018342:Receptors, Adrenergic, beta-1; D004247:DNA