Impact of buccal glucose spray, liquid sugars and dextrose tablets on the evolution of plasma glucose concentration in healthy persons.
OBJECTIVE
The purpose of this prospective controlled trial was to assess the efficacy of three commercially available glucose products, (1) buccal glucose spray, (2) liquid sugars, and (3) dextrose tablet, on the evolution of plasma glucose concentration (PG).


METHODS
Sixteen healthy volunteers aged 21.8 +/- 0.78 y (mean +/- SE), BMI 23.5 +/- 0.84 kg/m(2), tested their PG over the course of 3 sets of 4 sessions (S) each: S(0)-control fasting, S(1)-buccal administration of 10 glucose spray-doses (0.84 g of glucose) without swallowing; S(2-) consumption of 1 sachet (13 ml) of liquid sugar (ca. 5.2 g glucose, 5.2 g fructose, 5.2 g sucrose); S(3-) consumption of one dextrose tablet (6 g). PG was tested in finger-prick capillary blood using a personal glucometer Linus at the start, and at 5, 10, 15, 20 and 30 min. The means of 3 respective sessions for each of the 16 subjects were analyzed.


RESULTS
The Wilcoxon signed rank test revealed no significant differences between changes in the mean PG at the start vs. 5-minute interval either in control, or any intervention sessions. Analysis of regression coefficients after 30 min compared to the control session, demonstrated an increase in PG with the sachet of liquid sugars (0.068 mmol/l/min, p = 0.001) which was greater than a single dextrose tablet (0.052 mmol/l/min, p = 0.002), but no significant PG increase was found after buccal glucose spray.


CONCLUSIONS
Liquid sugars or dextrose tablets, but not the buccal glucose spray, are effective means to increase PG within 10 minutes after ingestion.
Chlup
Rudolf
R
Department of Physiology, Palacky University, Olomouc, Czech Republic. rudolf.chlup@fnol.cz
Zapletalova
Jana
J
Peterson
Karolina
K
Poljakova
Iveta
I
Lenhartova
Eva
E
Tancred
Adam
A
Perera
Russel
R
Smital
Jan
J
D000336:Aerosols; D001786:Blood Glucose / Q000187:drug effects*; D002241:Carbohydrates / Q000008:administration & dosage; D002610:Cheek; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D012016:Reference Values; D012996:Solutions; D013607:Tablets; D055815:Young Adult
D000336:Aerosols; D001786:Blood Glucose; D002241:Carbohydrates; D012996:Solutions; D013607:Tablets; D005947:Glucose