Is silent sinusitis a cause of chronic urticaria in children?
The etiologies of chronic urticaria (CU) comprise a wide variety of disorders including chronic infections. The association of sinusitis and CU is controversial due to the lack of a control group. The objective of this study was to investigate the role of silent sinusitis as a cause of CU in children. A sinus X-ray (SXR) was performed in 107 children with CU. SXR abnormalities were found in 52.3% of the patients. Nine patients (8.4%) had symptoms of sinusitis and were treated with amoxicillin/clavulanate. Five of these patients (55.6%) had CU remission. Forty-seven patients (43.9%) who had an abnormal SXR without sinusitis symptoms were randomized into treated (23 patients) and control (24 patients) groups. Eighteen patients (78.3%) in the treated group and 15 patients (62.5%) in the control group had CU remission (p = 0.24). These data did not support a causal relationship of sinusitis and CU in children.
Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. siojr@mahidol.ac.th
Orathai
O
Jirapongsananuruk
Preeda
P
Sangacharoenkit
Sureerat
S
Pongpreuksa
Nualanong
N
Visitsunthorn
Pakit
P
Vichyanond
D000293:Adolescent; D000658:Amoxicillin / Q000627:therapeutic use; D017332:Cetirizine / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D015508:Nasal Obstruction; D010256:Paranasal Sinuses / Q000187:drug effects* / Q000473:pathology; D011859:Radiography; D012074:Remission Induction; D012852:Sinusitis / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D014581:Urticaria / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology
D000658:Amoxicillin; D017332:Cetirizine