[An extremely painful ulcer on the lower leg; Martorell arteriolosclerotic ulcer].
A 63-year-old woman was referred to the dermatology outpatient department with extremely painful ulcers on the right lower leg. Medical history listed hypertension, diabetes mellitus and chronic obstructive pulmonary disease. Intensive analgesia was insufficient. Blood analysis, microbial cultures and venous ultrasound did not reveal a cause. At histopathologic examination of an ulcer, arteriolosclerosis was revealed. The patient was treated for Martorell arteriolosclerotic ulcer with nifedipine, acenocoumarol and split-thickness skin grafts followed by vacuum-assisted closure therapy. Two weeks postoperative, analgesia was discontinued and all ulcers were healed. Nifedipine and acenocoumarol were continued in the outpatient setting to prevent relapses. Patients with long-standing hypertension are particularly prone to cutaneous arteriolosclerosis. Thrombosis of the cutaneous arterioles results in painful ischemic ulcers. This disease probably frequently goes unrecognised.
Erasmus MC, afd. Dermatologie en Venereologie, Rotterdam, The Netherlands.
Suzan W I
SW
Reeder
Tom A
TA
Middelburg
H A Martino
HA
Neumann
D000074:Acenocoumarol / Q000627:therapeutic use; D050379:Arteriolosclerosis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use; D016038:Skin Transplantation; D016896:Treatment Outcome
D000074:Acenocoumarol; D009543:Nifedipine