One-pot facile synthesis of substituted isoindolinones via an Ugi four-component condensation/Diels-Alder cycloaddition/ deselenization-aromatization sequence.
A versatile one-pot synthesis of substituted isoindolinones from 2-furaldehydes, amines, 2-(phenylselanyl)acrylic acids, and isocyanides is described. The tandem process involves the Ugi four-component condensation, intramolecular Diels-Alder cycloaddition, and subsequent deselenization-aromatization promoted by BF(3)-OEt(2). The procedure is general and efficient and the substrates are easily available.
Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou 310028, People's Republic of China. huangx@mail.hz.zj.cn
Xian
X
Huang
Jianfeng
J
Xu
D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D007211:Indoles