[Effector function plasticity of T helper lymphocytes].
T helper (Th) cells are grouped into functionally different subsets (considered hitherto distinct and stable) according to their cytokine production. However, a number of recent findings show a much higher degree of Th cell plasticity and interconvertibility than previously assumed. Therefore, Th effector functions might be subject to therapeutic modulation even in late stages of immunopathological diseases.
Frey
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O
Institut für Immunologie, Universitätsklinikum Jena, Leutragraben 3, 07740, Jena, Deutschland. oliver.frey@mti.uni-jena.de
Kamradt
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T
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D016207:Cytokines / Q000097:blood*; D044127:Epigenesis, Genetic / Q000235:genetics / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology; D007125:Immunogenetics; D016130:Immunophenotyping; D007249:Inflammation / Q000276:immunology; D007376:Interleukin-2 / Q000502:physiology; D015847:Interleukin-4 / Q000502:physiology; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014157:Transcription Factors / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000502:physiology
D016207:Cytokines; D007376:Interleukin-2; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D015847:Interleukin-4