[Luminescence dynamics analysis on ruthenium polypyridyl complexes bonding to DNA].
Time-resolved spectra of six kinds of ruthenium polypyridyl complexes [Ru(L)2 (R)]2+ (L = bpy, phen, bpy = 2,2'-bipyridine, phen = 1,10-phenanthroline, R = 7-CH3-dppz, 7-F-dppz, dpbpd(NH2)2) bonding to calf thymus DNA in aqueous solution were compared and analyzed by using the three energy level kinetic model. And the effects of the substituent groups on the interaction ways for the ruthenium complexes bonding to DNA were discussed. The result shows that first, the six complexes all show two binding modes on bonding to DNA, i.e. the side-on binding mode and the perpendicular binding mode, and the later one is considered as a main binding way. Second, the properties of substituent groups have an important impact on the relative weight of the two binding modes. The conclusion offers a dynamics argument to study the interaction mechanism for the complex bonding to DNA further.
Zhu
Wei-Ling
WL
Department of Physics, Maoming University, Maoming 525000, China. mmzhuweiling@163.com
Liu
Xue-Wen
XW
Wang
Hui
H
Zheng
Kang-Cheng
KC
Ji
Liang-Nian
LN
D015082:2,2'-Dipyridyl / Q000737:chemistry; D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D008163:Luminescent Measurements; D009942:Organometallic Compounds / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*
D009942:Organometallic Compounds; D010618:Phenanthrolines; D015082:2,2'-Dipyridyl; D012428:Ruthenium; D004247:DNA; C427203:calf thymus DNA; C025205:1,10-phenanthroline