Induced pluripotent stem cells and reprogramming: seeing the science through the hype.
No-one can have failed to notice the splash that induced pluripotent stem (iPS) cells have made in the few years since somatic cells were first reprogrammed to pluripotency. But what is their real promise, where should research efforts be focused, and are we at a stage where we can replace embryonic stem cells? Four pioneering iPS cell researchers offer their personal insights into these and other questions of current debate. As well expressing hope for the improved understanding and treatment of human disease, they urge caution over safety and propose the establishment of iPS cell banks.
Center of Regenerative Medicine in Barcelona, Dr Aiguader 88, 08003 Barcelona, Spain. belmonte@salk.edu
Juan Carlos
JC
Izpisúa Belmonte
James
J
Ellis
Konrad
K
Hochedlinger
Shinya
S
Yamanaka
D000818:Animals; D054337:Cell Dedifferentiation; D065150:Cellular Reprogramming; D053595:Embryonic Stem Cells / Q000166:cytology; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*