NDP52: the missing link between ubiquitinated bacteria and autophagy.
Mammalian cells ubiquitinate bacteria that erroneously enter the cytosol and target these intruding microbes for destruction by autophagy. New work shows that the protein NDP52 directly binds to ubiquitinated bacteria and facilitates the assembly of an autophagic membrane that surrounds these invaders.
Ivanov
Stanimir
S
Roy
Craig R
CR
D001343:Autophagy; D006801:Humans; D009687:Nuclear Proteins / Q000276:immunology* / Q000378:metabolism; D011485:Protein Binding; D012480:Salmonella Infections / Q000276:immunology; D019779:Salmonella enterica / Q000276:immunology*; D025801:Ubiquitin / Q000276:immunology* / Q000378:metabolism; D054875:Ubiquitination
C094297:CALCOCO2 protein, human; D009687:Nuclear Proteins; D025801:Ubiquitin