[Role of prostate stem cell antigen in human pancreatic carcinoma: a tissue microarray-based study].
OBJECTIVE
To investigate the expression of prostate stem cell antigen (PSCA) in human pancreatic carcinoma and explore its role in the oncogenesis of pancreatic cancer.


METHODS
A pancreatic carcinoma tissue microarray was constructed, which contained 10 normal adult pancreas tissues, 12 chronic pancreatitis tissues and 78 pancreatic carcinomas. Immunohistochemistry was employed to detect the expression of PSCA, and the relation between PSCA expression and the clinicopathological factors of pancreatic carcinoma was analyzed.


RESULTS
The positivity rate of PSCA in pancreatic carcinoma was 79.5% (62/78), and PSCA staining was more intense in the malignant cells than in the benign cells (chi2=15.81, P<0.005) and chronic pancreatitis tissues (chi2=11.33, P<0.005). No obvious association was found between PSCA expression and the other variables of pancreatic carcinoma (including gender, age at surgery, tumor grade, and TNM stages).


CONCLUSIONS
The expression of PSCA can be related to the development of pancreatic cancer, but not to the clinicopathological factors of the tumor.
Department of General Surgery, Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710004, China. yangwb66@yahoo.com.cn
Wen-bin
WB
Yang
Feng
F
Cai
Chuan-tao
CT
Cheng
Gang
G
Cao
Zhao-yin
ZY
Qing
D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000235:genetics / Q000378:metabolism*; D044584:Carcinoma, Ductal / Q000276:immunology / Q000378:metabolism*; D005260:Female; D058851:GPI-Linked Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000276:immunology / Q000378:metabolism*; D046888:Tissue Array Analysis / Q000379:methods*
D000951:Antigens, Neoplasm; D058851:GPI-Linked Proteins; D009363:Neoplasm Proteins; C110843:PSCA protein, human