Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine.
In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R(+/+)), both heterozygous (D4R(+/-)) and knockout (D4R(-/-)) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.
Laboratory of Neuroimaging, NIAAA, NIH, Bethesda, MD, USA. thanos@bnl.gov
Panayotis K
PK
Thanos
Rahila
R
Habibi
Michael
M
Michaelides
Ujval B
UB
Patel
Katherine
K
Suchland
Brenda J
BJ
Anderson
John K
JK
Robinson
Gene-Jack
GJ
Wang
David K
DK
Grandy
Nora D
ND
Volkow
D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects* / Q000502:physiology*; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D005502:Food; D006579:Heterozygote; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D050638:Receptors, Dopamine D4 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D012646:Self Administration
D018765:Dopamine Uptake Inhibitors; D050638:Receptors, Dopamine D4; D003042:Cocaine