Effect of fenugreek seeds on blood glucose and lipid profiles in type 2 diabetic patients.
BACKGROUND
Recently use of herbal medicines, have been considered as an alternative for therapeutic usage. So, this study was undertaken to evaluate the hypoglycemic and hypolipidemic effects of fenugreek seeds in type 2 diabetic patients.


METHODS
In a clinical trial study, 24 type 2 diabetic patients were placed on 10 grams/day powdered fenugreek seeds mixed with yoghurt or soaked in hot water for 8 weeks. Weight, FBS, HbA(1)C, total cholesterol, LDL, HDL and food record were measured before and after the study. The differences observed in food records, BMI and serum variables were analyzed using paired-t-test and t-student and P<or=0.05 was considered as significant.


RESULTS
After exclusion of 6 cases for changing in medication or personal problems, the results of 18 patients (11 consumed fenugreek in hot water and 7 in yoghurt) were studied. Findings showed that FBS, TG and VLDL-C decreased significantly (25 %, 30 % and 30.6 % respectively) after taking fenugreek seed soaked in hot water whereas there were no significantly changes in lab parameters in cases consumed it mixed with yoghurt. BMI, Energy, Carbohydrate, Protein and fat intake remained unchanged during study.


CONCLUSIONS
This study shows that fenugreek seeds can be used as an adjuvant in the control of type 2 diabetes mellitus in the form of soaked in hot water.
Kassaian
Nazila
N
Infectious Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Arbabnia_mn@Yahoo.com
Azadbakht
Leila
L
Forghani
Badrolmolook
B
Amini
Masud
M
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D015930:Diet Records; D005215:Fasting / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D012639:Seeds; D029910:Trigonella
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D008055:Lipids; C517652:hemoglobin A1c protein, human