PLGA particle production for water-soluble drug encapsulation: degradation and release behaviour.
Particles for subcutaneous depot use encapsulating a model water-soluble drug have been produced from poly(lactic-glycolic acid) (PLGA) using a membrane emulsification-solvent evaporation technique. The release behaviour, mainly the change in size and inner morphology are reported. During release, the particles initially swelled in size, then reduced. A diffusion based model, taking in to account the change in particle size, is presented. Surface erosion is evident from the particle size and image evidence, and the diffusion model provides a fit to the data even during the surface erosion period, suggesting that the model drug diffuses before the particle degrades.
Department of Chemical Engineering, Loughborough University, Leicestershire, LE11 3TU, UK.
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G
Gasparini
R G
RG
Holdich
S R
SR
Kosvintsev
D004655:Emulsions; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D009997:Osmotic Pressure; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016062:Porosity; D012965:Sodium Chloride / Q000494:pharmacology; D012995:Solubility; D014867:Water / Q000737:chemistry*
D004655:Emulsions; D004364:Pharmaceutical Preparations; D014867:Water; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D012965:Sodium Chloride