Emergence of Crimean-Congo haemorrhagic fever in Greece.
In the summer of 2008, the first case of Crimean-Congo haemorrhagic fever (CCHF) was observed in Greece. The laboratory diagnosis was established using nested RT-PCR and quantitative real-time RT-PCR. A high viral load and increased levels of cytokines were detected on the third day of illness and the patient died 7 days after the onset of symptoms. Nucleotide sequence analysis revealed that the Greek CCHF virus strain had high sequence identity with other Balkan CCHF virus strains.
Papa
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A
First Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. annap@med.auth.gr
Dalla
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V
Papadimitriou
E
E
Kartalis
G N
GN
Antoniadis
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A
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001483:Base Sequence; D016207:Cytokines / Q000032:analysis; D005260:Female; D006115:Greece / Q000453:epidemiology; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000276:immunology / Q000302:isolation & purification* / Q000472:pathogenicity; D006479:Hemorrhagic Fever, Crimean / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis; D012423:Rural Health; D016036:Seroepidemiologic Studies; D013987:Ticks / Q000821:virology*
D000914:Antibodies, Viral; D016207:Cytokines; D012367:RNA, Viral