Cytotoxic and anticarcinogenic activity of the ent-kaurene diterpenoid, melissoidesin, from Isodon wightii (Bentham) H. Hara.
Isodon wightii is a common plant found in the Western Ghats of South India. The ent-kaurene diterpenoid melissoidesin, isolated from the leaves of I. wightii, showed significant cytotoxicity against lung cancer and neuroblastoma cell lines with IC(50) values of 6 and 4.2 microg mL(-1), respectively. The prevention of deoxyribose degradation activity of melissoidesin was significant and the IC(50) value was calculated to be 163.1 microg mL(-1). The anticarcinogenic activity of melissoidesin by comet assay showed significant DNA damage protecting activity in a dose-dependent manner.
Department of Botany, Bharathiar University, Tamil Nadu, India. thirugnanasampandan@yahoo.co.in
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Thirugnanasampandan
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Jayakumar
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity*; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D020552:Comet Assay; D003855:Deoxyribose / Q000378:metabolism; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity*; D006801:Humans; D007194:India; D037602:Isodon / Q000737:chemistry*; D008175:Lung Neoplasms / Q000188:drug therapy; D008214:Lymphocytes / Q000187:drug effects; D015394:Molecular Structure; D009447:Neuroblastoma / Q000188:drug therapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D018515:Plant Leaves / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; D010936:Plant Extracts; C530841:melissoidesin; D003855:Deoxyribose