An efficient one-pot synthesis of 2,3-epoxyl-1,3-diaryl-1-propanone directly from acetophenones and aromatic aldehydes under ultrasound irradiation.
A convenient and efficient one-pot synthesis of 2,3-epoxyl-1,3-diaryl-1-propanone directly from acetophenones and aromatic aldehydes under ultrasound irradiation at room temperature has been described. In comparison to two-step methods, the present procedure has the advantages of mild conditions, shorter reaction time, without isolation of any intermediate, saves energy and no requirement of toxic solvent.
College of Chemistry and Environmental Science, Hebei University, Baoding, PR China. lijitai@hbu.cn
Ji-Tai
JT
Li
Ying
Y
Yin
Ming-Xuan
MX
Sun
D000098:Acetophenones / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D001547:Benzaldehydes / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods; D004852:Epoxy Compounds / Q000138:chemical synthesis*; D006878:Hydroxides / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D017680:Potassium Compounds / Q000737:chemistry; D011407:Propane / Q000138:chemical synthesis*; D012997:Solvents / Q000737:chemistry; D013696:Temperature; D013997:Time Factors; D014465:Ultrasonics
D000098:Acetophenones; D000447:Aldehydes; D001547:Benzaldehydes; D004852:Epoxy Compounds; D006878:Hydroxides; D017680:Potassium Compounds; D012997:Solvents; D011407:Propane; C029943:potassium hydroxide