Chemical constituents of Crinum asiaticum L. var. sinicum Baker and their cytotoxic activities.
A phytochemical investigation of the bulbs of Crinum asiaticum L. var. sinicum Baker resulted in the isolation of two new alkaloids, asiaticumines A and B (1 and 2, resp.), together with 21 known compounds, including nine alkaloids, four amides, five phenolic compounds, and three flavonoids. All 23 compounds were isolated for the first time from Crinum asiaticum L. var. sinicum Baker. Their structures were elucidated by spectroscopic methods. In addition, ten alkaloids, 1-10, were evaluated for their cytotoxic activities against human tumor cell lines A549, LOVO, HL-60, and 6T-CEM. Compounds 3, 4, and 7-10 selectively showed remarkable inhibition against one or more of the tested cell lines.
Sun
Qian
Q
Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
Shen
Yun-Heng
YH
Tian
Jun-Mian
JM
Tang
Jian
J
Su
Juan
J
Liu
Run-Hui
RH
Li
Hui-Liang
HL
Xu
Xi-Ke
XK
Zhang
Wei-Dong
WD
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D000577:Amides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D045744:Cell Line, Tumor; D031407:Crinum / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D013057:Spectrum Analysis
D000470:Alkaloids; D000577:Amides; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; C547638:asiaticumine A; C547639:asiaticumine B