Stereoselective synthesis of bicyclic tertiary alcohols with quaternary stereocenters via intramolecular crossed benzoin reactions catalyzed by N-heterocyclic carbenes.
Bicyclic tertiary alcohols 1 bearing quaternary stereocenters at the two adjacent bridgehead positions were synthesized with high stereoselectivity via the intramolecular crossed benzoin reactions catalyzed by NHC organocatalysts.
Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama 700-8530, Japan.
Tadashi
T
Ema
Yoshitaka
Y
Oue
Kumiko
K
Akihara
Yuki
Y
Miyazaki
Takashi
T
Sakai