HLA-B*0777 allele differs from B*0707 by a single residue in the antigen binding groove.
Human leukocyte antigen (HLA) class I sequence-based typing (SBT) for hematopoietic unrelated donor searching in a Romanian Caucasian patient showed the presence of a novel HLA-B allele defined as B*0777. HLA-B*0777 has two nucleotides changes at the same codon from B*0707, resulting an amino acid replacement 99Y > 99S.
Histocompatibilidad, Centro de Transfusión de la Comunidad de Madrid, Madrid, Spain. abalas.trans@salud.madrid.org
A
A
Balas
D
D
Planelles
G F
GF
Sanz
J A
JA
Montoro
J L
JL
Vicario
D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D001665:Binding Sites; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D015235:HLA-B Antigens