FABP4: a novel candidate gene for polycystic ovary syndrome.
BACKGROUND
Polycystic ovary syndrome (PCOS) is a complex multifactorial disorder involving a number of genetic and environmental factors. Adipocyte-fatty acid-binding protein (FABP4) is an adipokine regulating systemic insulin sensitivity, lipid and glucose metabolism. In humans serum FABP4 levels correlate significantly with features of PCOS. Previous researches showed strong evidences that FABP4 impacted the developing of PCOS possibly through its protein alteration or transcription regulation. Thus, the present study is the first attempt to identify the possible genetic role of FABP4 gene in the development of PCOS.


METHODS
About 1000 bp of the promoter region and four exons of FABP4 gene of 178 PCOS patients and 171 healthy controls were directly sequenced.


RESULTS
Three polymorphisms, rs16909225, rs3834363, and rs16909220, were identified, of which rs16909225 and rs16909220 were completely linked (r² = 1) and not associated with the development of PCOS, while the -2-bp/-2-bp genotype of rs3834363 was significantly higher in PCOS than in the controls (χ² = 7.39, df = 1, P = 0.007, OR = 1.80 95% CI: 1.18-2.75).


CONCLUSIONS
The present study is the first to establish an association between FABP4 gene polymorphisms and the development of PCOS.
Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
Jing
J
Wang
Jingwen
J
Tang
Binbin
B
Wang
Junjie
J
Song
Jingjing
J
Liu
Zhaolian
Z
Wei
Feng
F
Zhang
Xu
X
Ma
Yunxia
Y
Cao
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins