Expression of CD40 and CD40L in gastric cancer tissue and its clinical significance.
To study expression of CD40 and CD40L in gastric cancer tissue we assessed gastric cancer patients admitted to the Department of Gastroenterology of The First Affiliated Hospital of Soochow University and control subjects. Gastric cancer and normal (from around tumours) tissue samples were obtained from patients. Venous blood samples (gastric cancer and ulcer groups) were drawn on the morning of the day before surgery for the measurement of peripheral sCD40L. The expression of CD40 in gastric carcinoma specimens was examined immuno-histochemically. The clinicopathological factors, including age, sex, tumor size, gross appearance, degree of cellular differentiation, histological classification, depth of tumor invasion, lymph node metastasis, peritoneal dissemination, and TNM stage were analyzed according to the different expression of CD40. The results indicated a high CD40 expression in gastric cancer tissues. This positive expression of CD40 revealed a significant (P < 0.05) correlation with lymphatic metastasis and tumor TNM stage in gastric cancer patients. It is concluded that higher CD40 expression existed in expanding type tumors and could play an important role in clinical diagnosis of gastric cancer patients.
Li
Rui
R
Department of Gastroenterology, First Affiliated Hospital of Soochow University; Key Laboratory of Medicine and Clinical Immunology of Jiangsu Province, Suzhou 215006, China.
Chen
Wei-Chang
WC
Department of Gastroenterology, First Affiliated Hospital of Soochow University; Key Laboratory of Medicine and Clinical Immunology of Jiangsu Province, Suzhou 215006, China.
Pang
Xue-Qin
XQ
Department of Gastroenterology, First Affiliated Hospital of Soochow University; Key Laboratory of Medicine and Clinical Immunology of Jiangsu Province, Suzhou 215006, China.
Hua
Chen
C
Department of Emergency, Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Li
Ling
L
Department of Gastroenterology, First Affiliated Hospital of Soochow University; Key Laboratory of Medicine and Clinical Immunology of Jiangsu Province, Suzhou 215006, China.
Zhang
Xue-Guang
XG
Institute of Medical Biotechnology, Soochow University, Suzhou 215007, China.
D000328:Adult; D000368:Aged; D019013:CD40 Antigens / Q000378:metabolism*; D023201:CD40 Ligand / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D018260:Gelsolin / Q000378:metabolism; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D053668:Syndecan-1 / Q000378:metabolism; D051996:Transcription Factor RelA / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D055815:Young Adult
D019013:CD40 Antigens; D018260:Gelsolin; C498143:RELA protein, human; C508241:SDC1 protein, human; D053668:Syndecan-1; C495901:TP53 protein, human; D051996:Transcription Factor RelA; D016159:Tumor Suppressor Protein p53; D023201:CD40 Ligand