Systemic high-sensitivity C-reactive protein level in pseudoexfoliation syndrome and pseudoexfoliation glaucoma.
OBJECTIVE
To evaluate the systemic high sensitivity C-reactive protein (hsCRP) levels in patients with pseudoexfoliation syndrome (XFS) and pseudoexfoliation glaucoma (XFG).


METHODS
We prospectively examined 31 patients with XFS, 26 with XFG, and 25 controls. To the study patients with the exclusion of serious hypertension that do not have any cardiovascular and cerebrovascular disease and that diagnosed as XFS and XFG have been included. Each patient passed through a detailed blood sampling including hsCRP, biochemistry, and lipid profile. Plasma C-reactive protein (CRP) levels were measured with nephelometric method by using Beckman IMMAGE hsCRP reagent.


RESULTS
Each group had similar demographic parameters including age, sex, body mass index, heart rate, and blood pressure. When we compared with controls, there was no statistically significant difference in the hsCRP and biochemistry results between the 3 groups. When all patients with pseudoexfoliation (PEX) compared with controls there was no difference.


CONCLUSIONS
Our findings indicated no difference in the hsCRP level between XFS, XFG, and controls. This study suggests that CRP is not a predictive marker of inflammation and peripheral endothelial dysfunction in XFS, which is accepted as a systemic disorder.
Yüksel
Nurşen
N
Kocaeli University School of Medicine, Kocaeli, Turkey.
Pirhan
Dilara
D
Altintaş
Ozgül
O
Cağlar
Yusuf
Y
D000368:Aged; D001794:Blood Pressure; D001824:Body Constitution; D002097:C-Reactive Protein / Q000378:metabolism*; D017889:Exfoliation Syndrome / Q000097:blood*; D005260:Female; D005901:Glaucoma / Q000097:blood*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D009391:Nephelometry and Turbidimetry; D011446:Prospective Studies
D002097:C-Reactive Protein