CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : VI. THE SYNTHESIS OFp-AMINOPHENOLalpha-GLUCOSIDE AND ITS COUPLING WITH PROTEIN.
1. The synthesis of p-aminophenol alpha-glucoside has been described. This glucoside can be coupled to any protein to yield a synthetic alpha-glucoside-protein complex. 2. A synthetic beta-glucoside-protein complex has also been prepared. 3. These synthetic sugar-protein complexes have been used as immunizing antigens in order to ascertain whether alpha- and beta-glucosidic unions influence the specificity of the immune response in animals. The results of the immunological studies are presented in the following paper.
Hospital of The Rockefeller Institute for Medical Research.
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WF
Goebel
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FH
Babers
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Avery