Efficacy of posaconazole in a murine disseminated infection by Candida tropicalis.
We evaluated the efficacy of posaconazole against Candida tropicalis in a systemic infection model with immunosuppressed mice. Posaconazole at 50 mg/kg of body weight/day prolonged the survival of mice and reduced the fungal tissue burden of mice infected with any of the five strains tested, with the exception of one strain that had a high MIC against this drug. Our results demonstrate the efficacy of posaconazole in the treatment of invasive murine infection caused by C. tropicalis.
Unitat de Microbiologia, Facultat de Medicina, IISPV, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201, Reus, Spain.
Marçal
M
Mariné
F Javier
FJ
Pastor
Josep
J
Guarro
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001822:Body Burden; D041022:Candida tropicalis / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D007165:Immunosuppression Therapy; D053208:Kaplan-Meier Estimate; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D013534:Survival; D014230:Triazoles / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole