Bromodecarboxylation of quinoline salicylic acids: increasing the diversity of accessible substituted quinolines.
Quinoline salicylic acids underwent bromodecarboxylation at room temperature upon treatment with N-bromosuccinimide. A wide variety of functional groups was tolerated. Several one-pot transformations were also carried out, allowing the preparation of diverse 4-substituted quinolines.
Wyeth Research, Department of Chemical Sciences, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA. kjanz@wyeth.com
Kristin
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Janz
Neelu
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Kaila
D003653:Decarboxylation; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D012459:Salicylates / Q000737:chemistry*; D013237:Stereoisomerism
D011804:Quinolines; D012459:Salicylates