Chemical constituents from the whole plant of Gaultheria itoana Hayata.
Two new diterpenoids, 14,18-dihydroxyabieta-8,11,13-trien-7-one (1) and 13-acetyl-14,18-dihydroxy-podocarpa-8,11,13-triene (2), together with eight known compounds, i.e., gaultheric acid (3), vanillic acid (4), 4-hydroxybenzoic acid (5), cinnamic acid (6), stearic acid (7), palmitic acid (8), beta-sitosterol (9), and stigmasterol (10), were isolated from the MeOH extract of the whole plant of Gaultheria itoana Hayata (Ericaceae). The structures of the new constituents were elucidated by spectroscopic methods (UV, IR, and 1D- and 2D-NMR) and by mass spectrometry (HR-ESI-MS). Among them, 1 and 2 were demonstrated to exhibit significant cytotoxic activity against the LNCaP cell line.
Chen
Chung-Yi
CY
Department of Medical Technology, School of Medical and Health Science, Fooyin University, Kaohsiung 831, Taiwan.
Lin
Rong-Jyh
RJ
Huang
Jin-Cherng
JC
Wu
Yi-Hung
YH
Cheng
Ming-Jen
MJ
Hung
His-Chou
HC
Lo
Wen-Li
WL
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D031282:Gaultheria / Q000737:chemistry*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry; D015394:Molecular Structure; D019308:Palmitic Acid / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010226:Parabens / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D012855:Sitosterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013229:Stearic Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013265:Stigmasterol / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014641:Vanillic Acid / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
C547636:14,18-dihydroxyabieta-8,11,13-trien-7-one; D000972:Antineoplastic Agents, Phytogenic; D002934:Cinnamates; D004224:Diterpenes; D010226:Parabens; D010936:Plant Extracts; D012855:Sitosterols; D013229:Stearic Acids; C029010:cinnamic acid; D019308:Palmitic Acid; C031183:stearic acid; D013265:Stigmasterol; D014641:Vanillic Acid; C038193:4-hydroxybenzoic acid; D000432:Methanol