Relationship between plasma uridine and urinary urea excretion.
To investigate whether the concentration of uridine in plasma is related to the urinary excretion of urea, 45 healthy male subjects with normouricemia and normal blood pressure were studied after providing informed consent. Immediately after collection of 24-hour urine, blood samples were drawn after an overnight fast except for water. The contents of ingested foods during the 24-hour urine collection period were described by the subjects and analyzed by a dietician. Simple regression analysis showed that plasma uridine was correlated with the urinary excretions of urea (R = 0.41, P < .01), uric acid (R = 0.36, P < .05), and uridine (R = 0.30, P < .05), as well as uric acid clearance (R = 0.35, P < .05) and purine intake (R = 0.30, P < .05). In contrast, multiple regression analysis showed a positive relationship only between plasma uridine and urinary excretion of urea. These results suggest that an increase in de novo pyrimidine synthesis leads to an increased concentration of uridine in plasma via nitrogen catabolism in healthy subjects with normouricemia and normal blood pressure.
Ka
Tuneyoshi
T
Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-6801, Japan.
Inokuchi
Taku
T
Tamada
Daisuke
D
Suda
Michio
M
Tsutsumi
Zenta
Z
Okuda
Chihiro
C
Yamamoto
Asako
A
Takahashi
Sumio
S
Moriwaki
Yuji
Y
Yamamoto
Tetsuya
T
D000328:Adult; D003404:Creatinine / Q000652:urine; D004032:Diet; D004040:Dietary Carbohydrates / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism; D004044:Dietary Proteins / Q000378:metabolism; D006073:Gout / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D014508:Urea / Q000652:urine*; D014527:Uric Acid / Q000652:urine; D014529:Uridine / Q000097:blood*
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D014527:Uric Acid; D014508:Urea; D003404:Creatinine; D014529:Uridine