Chronic exposures to cholinesterase-inhibiting pesticides adversely affect respiratory health of agricultural workers in India.
OBJECTIVE
The impact of long term exposure to cholinesterase (ChE)-inhibiting organophosphate (OP) and carbamate (C) pesticides on the respiratory health of agricultural workers in India was investigated.


METHODS
Three hundred and seventy-six nonsmoking agricultural workers (median age 41 yr) from eastern India who sprayed OP and C pesticides in the field and 348 age- and sex-matched control subjects with non-agricultural occupations from the same locality were enrolled. Prevalence of respiratory symptoms was obtained by questionnaire survey, and pulmonary function tests were carried out by spirometry. Chronic obstructive pulmonary disease (COPD) was diagnosed by the Global Obstructive Lung Disease (GOLD) criteria, and erythrocyte acetylcholinesterase (AChE) was measured by the Ellman method.


RESULTS
Agricultural workers had greater prevalences of upper and lower respiratory symptoms, and appreciable reduction in spirometric measurements. Overall, lung function reduction was noted in 48.9% of agricultural workers compared with 22.7% of control, and a restrictive type of deficit was predominant. COPD was diagnosed in 10.9% of agricultural workers compared with 3.4% of controls (p<0.05 in chi(2) test), and the severity of the disease was greater in agricultural workers. Red blood cell (RBC) AChE was lowered by 34.2% in agricultural workers, and the fall in AChE level was positively associated with respiratory symptoms, lung function decrement and COPD after controlling for education and income as potential confounders.


CONCLUSIONS
Long-term exposure to cholinesterase-inhibiting agricultural pesticides currently in use in India is associated with a reduction in lung function, COPD and a rise in respiratory symptoms.
Chakraborty
Sreeparna
S
Department of Experimental Hematology, Chittaranjan National Cancer Institute, Kolkata 700 026, India.
Mukherjee
Sayali
S
Roychoudhury
Sanghita
S
Siddique
Shabana
S
Lahiri
Twisha
T
Ray
Manas Ranjan
MR
D000328:Adult; D000382:Agricultural Workers' Diseases / Q000139:chemically induced* / Q000453:epidemiology; D002219:Carbamates / Q000506:poisoning*; D016022:Case-Control Studies; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D062025:Organophosphate Poisoning; D010575:Pesticides / Q000506:poisoning*; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000139:chemically induced* / Q000453:epidemiology; D012137:Respiratory System / Q000187:drug effects / Q000503:physiopathology; D012720:Severity of Illness Index; D013147:Spirometry; D011795:Surveys and Questionnaires; D055815:Young Adult
D002219:Carbamates; D002800:Cholinesterase Inhibitors; D010575:Pesticides