Molecular toxicology of substances released from resin-based dental restorative materials.
Resin-based dental restorative materials are extensively used today in dentistry. However, significant concerns still remain regarding their biocompatibility. For this reason, significant scientific effort has been focused on the determination of the molecular toxicology of substances released by these biomaterials, using several tools for risk assessment, including exposure assessment, hazard identification and dose-response analysis. These studies have shown that substances released by these materials can cause significant cytotoxic and genotoxic effects, leading to irreversible disturbance of basic cellular functions. The aim of this article is to review current knowledge related to dental composites' molecular toxicology and to give implications for possible improvements concerning their biocompatibility.
Bakopoulou
Athina
A
Department of Fixed & Implant Prosthodontics, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece.
Papadopoulos
Triantafillos
T
Department of Biomaterials, School of Dentistry, National and Kapodistrian University of Athens, Athens, 115 27, Greece.
Garefis
Pavlos
P
Department of Fixed & Implant Prosthodontics, School of Dentistry, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece.
D000818:Animals; D001419:Bacteria / Q000187:drug effects; D004249:DNA Damage; D006801:Humans; D008689:Methacrylates / Q000493:pharmacokinetics / Q000633:toxicity*; D009055:Mouth / Q000187:drug effects / Q000382:microbiology; D058105:Polymerization; D011109:Polymethacrylic Acids / Q000493:pharmacokinetics / Q000633:toxicity*; D012117:Resins, Synthetic / Q000493:pharmacokinetics / Q000633:toxicity*
D008689:Methacrylates; D011109:Polymethacrylic Acids; D012117:Resins, Synthetic