Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin-dextran as a novel MRI contrast agent.
5-(4-Aminophenyl)-10,15,20-tris(4-sulfonatophenyl) manganese(III) porphyrin conjugated with dextran was synthesized. Its potential of being used as a tumor-targeting magnetic resonance imaging contrast agent was evaluated in vitro and in vivo. The results demonstrated that the compound has a longitudinal relaxivity (R(1)) higher than Gd-DTPA, low cytotoxicity and binding specificity to tumor cell membrane.
Zhang
Zhi
Z
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.
He
Rui
R
Yan
Kun
K
Guo
Qian-ni
QN
Lu
Yun-guo
YG
Wang
Xu-xia
XX
Lei
Hao
H
Li
Zao-ying
ZY
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003287:Contrast Media / Q000138:chemical synthesis* / Q000494:pharmacology; D003911:Dextrans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008665:Metalloporphyrins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D013997:Time Factors
D003287:Contrast Media; D003911:Dextrans; D008665:Metalloporphyrins