[Biological markers for diagnosis of myeloid leukemia].
There are several important biological markers in myeloid leukemia. In particular, WT1, FLT3, P-glycoprotein (P-gp) and surface antigens are important biologic markers. When we monitor the treatment of leukemia, WT1 is considered to be an important marker, and has been applied to immune therapy. The abnormality of the genes of FLT3 and expression of P-gp are poor prognostic factors, and their inhibitors are developed in progress. The surface antigen analysis of blast cells is also used in the classification and the treatment strategy decision. Recently, as for the treatment of leukemia, stratification by various kinds of factors has been adopted in many prospective studies. The results of these biological markers are utilized for the stratification.
Laboratory Medicine, Hamamatsu University School of Medicine.
Akihiro
A
Takeshita
Kaori
K
Shinjo
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis; D015703:Antigens, CD / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D006021:Glycophorins / Q000032:analysis; D007951:Leukemia, Myeloid / Q000175:diagnosis* / Q000235:genetics*; D025721:WT1 Proteins / Q000032:analysis*; D051941:fms-Like Tyrosine Kinase 3 / Q000032:analysis*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D015703:Antigens, CD; D014408:Biomarkers, Tumor; D006021:Glycophorins; D025721:WT1 Proteins; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3