Temporal hypoperfusion assessed by cerebral blood flow SPECT and long-term clinical outcome in patients with eating disorders.
OBJECTIVE
To evaluate the relationship between temporal hypoperfusion in the acute phase of patients with eating disorders and the long-term clinical outcome.


METHODS
Brain perfusion was studied using Tc-99m HMPAO SPECT in 17 patients with eating disorders (ED) and compared with 12 controls (C). Semiquantitative analysis was carried out by left/right indexes. Clinical records were reviewed 15 years later and the patients were classified into 2 groups: bad outcome in 10 patients and good outcome in 4. The results of the basal SPECT were compared with the clinical outcome.


RESULTS
The mean of the differences of temporal perfusion in the lower slice was 0.1476 +/- 0.1121 in ED and 0.03 +/- 0.019 in C (P < 0.001). Comparisons between C and bad outcome showed a significant difference (P < 0.01). There was no significant difference between good outcome and C.


CONCLUSIONS
The temporal hypoperfusion in the acute phase of patients with ED showed a correlation with the long-term clinical outcome and suggested a prognostic value of temporal hypoperfusion.
Jiménez-Bonilla
Julio F
JF
Department of Nuclear Medicine, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Cantabria, España. jjimenez@humv.es
Quirce
Remedios
R
Banzo
Ignacio
I
Martínez-Rodríguez
Isabel
I
Sainz-Esteban
Aurora
A
Portilla
Humberto
H
Carril
José Manuel
JM
D000293:Adolescent; D000328:Adult; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002648:Child; D001068:Feeding and Eating Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D055420:Perfusion Imaging / Q000379:methods*; D013702:Temporal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D016896:Treatment Outcome