INHIBITION OF THE SHWARTZMAN PHENOMENON.
The Shwartzman phenomenon can be inhibited by an intravenous injection of a potent bacterial filtrate within a few hours before or after the preparatory intradermal injection. The inhibitory effect is produced non-specifically by filtrates potent in the elicitation of the Shwartzman phenomenon, and it is of a transitory nature. The relation of the observation described to anaphylactic desensitization and to its clinical significance is discussed in this paper.
Laboratories of The Mount Sinai Hospital, New York, and the Serochemical Institute of the Tokyo Imperial University Medical School, Tokyo, Japan.
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