Autologous chondrocytes implantation with three-dimensional collagen scaffold.
OBJECTIVE
The authors report a patient with large traumatic knee cartilage defects treated with autologous chondrocytes implantation (ACI) in three-dimensional collagen scaffold.


METHODS
A patient with grade 3-4 according to ICRS (International Cartilage Repair Society) Classification System was performed ACI with three-dimensional collagen scaffold. The two-stage procedure was performed First, the cartilage was arthroscopic harvested. The chondrocytes were isolated in the laboratory. Second, the chondrocytes were re-implanted into the defects using three-dimensional collagen scaffold. The patients were clinically evaluated pre-operatively and post operatively and magnetic resonance imaging. The duration of follow-up was 12 months.


RESULTS
There was no post operative complication. The clinical evaluations were excellent. The MRI showed the hyaline-like cartilage tissue formation at the defects.


CONCLUSIONS
The autologous chondrocytes implantation with three-dimensional collagen scaffold showed the excellent outcome. Long-term follow-up is required.
Department of Orthopedics, Faculty of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakhrinwirot University, Bangkok, Thailand. chann@swu.ac.th
Channarong
C
Kasemkijwattana
Suraphol
S
Kesprayura
Kanda
K
Chaipinyo
Cholawish
C
Chanlalit
Kosum
K
Chansiri
D000328:Adult; D019902:Chondrocytes / Q000637:transplantation*; D005260:Female; D006801:Humans; D007718:Knee Injuries / Q000601:surgery*; D000070600:Tibial Meniscus Injuries; D054457:Tissue Scaffolds; D014182:Transplantation, Autologous