Retinal vascular abnormalities in patients with cerebral amyloid angiopathy.
OBJECTIVE
To describe the ophthalmology findings in patients with cerebral amyloid angiopathy (CAA).


METHODS
Data source and subjects: 7 consecutive patients admitted to a tertiary stroke unit with CAA-related hemorrhage, confirmed on magnetic resonance brain imaging gradient echo sequences by 2 independent neuroradiologists.


METHODS
case series. Measurements and data analysis: fundus colored photographs and fundus fluorescein angiography.


RESULTS
All patients showed bilateral multiple dot and blot hemorrhages as well as multiple microaneurysms on fundus fluorescein angiography.


CONCLUSIONS
Microaneurysms and dot and blot hemorrhages funduscopically mirror the histopathology of CAA. This case series is the first to describe retinal vessel changes in CAA and, if confirmed in larger population studies, has the potential to provide insights into the natural history of CAA.
Department of Cerebrovascular Neurology, Flinders Medical Centre, Bedford Drive, Bedford Park, S.A. 5042, Australia.
Andrew
A
Lee
Adam
A
Rudkin
Marc
M
Agzarian
Sandy
S
Patel
Stewart
S
Lake
Celia
C
Chen
D000368:Aged; D000369:Aged, 80 and over; D000783:Aneurysm / Q000175:diagnosis* / Q000453:epidemiology; D016657:Cerebral Amyloid Angiopathy / Q000150:complications*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D015994:Incidence; D008279:Magnetic Resonance Imaging; D008297:Male; D019721:Ophthalmoscopes; D011446:Prospective Studies; D012161:Retinal Artery; D012164:Retinal Diseases / Q000175:diagnosis* / Q000453:epidemiology; D012166:Retinal Hemorrhage / Q000175:diagnosis* / Q000453:epidemiology; D012189:Retrospective Studies