[Humanized model for acute myeloid leukemia].
To investigate human hematopoiesis and immunity in vivo, we have been making efforts to reconstitute these systems in mice by intravenously injecting purified human stem cells into NOD/SCID/IL2rgKO newborns. This xenogeneic transplantation system supports long-term engraftment, multi-lineage differentiation, and self-renewal capacity of human cord blood-derived hematopoietic stem cells (HSCs). We here introduce our recent application of the NOD/SCID/IL2rgKO newborn xenotransplant system to create in vivo models for human hematological malignancies and to understand pathophysiology of human AML.
Ishikawa
Fumihiko
F
Research Unit for Human Disease Models, RIKEN Research Center for Allergy and Immunology.
D000818:Animals; D000831:Animals, Newborn; D036101:Cord Blood Stem Cell Transplantation; D004195:Disease Models, Animal; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D014411:Neoplastic Stem Cells; D014183:Transplantation, Heterologous