Renoprotection by alpha-Mangostin is related to the attenuation in renal oxidative/nitrosative stress induced by cisplatin nephrotoxicity.
Cisplatin (CDDP) is a chemotherapeutic agent that produces nephrotoxicity associated with oxidative/nitrosative stress. alpha-Mangostin (alpha-M) is a xanthone extracted from mangosteen with antioxidant and anti-inflammatory properties. The purpose of this study was to evaluate the renoprotective effect of alpha-M on the CDDP-induced nephrotoxicity. alpha-M was administered (12.5 mg/kg/day, i.g.) for 10 days (7 days before and 3 days after CDDP injection). On day 7, rats were treated with a single injection of CDDP (7.5 mg/Kg, i.p.); 3 days after the rats were killed. alpha-M attenuated renal dysfunction, structural damage, oxidative/nitrosative stress, decrease in catalase expression and increase in mRNA levels of tumour necrosis factor alpha and transforming growth factor beta. In conclusion the renoprotective effect of alpha-M on CDDP-induced nephrotoxicity was associated with the attenuation in oxidative/nitrosative stress and inflammatory and fibrotic markers and preservation of catalase activity.
Facultad de Química, Departamento de Biología, Universidad Nacional Autónoma de México, Edificio F, Mexico City, Mexico.
Jazmin M
JM
Pérez-Rojas
Cristino
C
Cruz
Patricia
P
García-López
Dolores J
DJ
Sánchez-González
Claudia M
CM
Martínez-Martínez
Gisela
G
Ceballos
Magali
M
Espinosa
Jorge
J
Meléndez-Zajgla
José
J
Pedraza-Chaverri
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000633:toxicity; D000975:Antioxidants / Q000494:pharmacology; D002945:Cisplatin / Q000493:pharmacokinetics / Q000633:toxicity*; D004347:Drug Interactions; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D044004:Xanthones / Q000494:pharmacology*
D000970:Antineoplastic Agents; D000975:Antioxidants; D044004:Xanthones; D002945:Cisplatin; C021053:mangostin