Interaction of VEGF to gastric low grade MALT lymphoma by Helicobacter heilmannii infection in C57/BL/6 mice.
Helicobacter heilmannii (Hh) has been clinically reported to have some relation to gastric low grade MALT lymphoma. Recently, we have formed the gastric MALT lymphoma in C57BL/6 mice.


METHODS
C57BL/6 mice infected with Hh from cynomolgus monkey for more than 6 months were used. The macroscopic, immunohistochemical and electron microscopic observation was performed


RESULTS
MALT lymphoma was formed in almost 100% of the infected mice. Increased VEGF-A and Flt-3 immunoreactivity was recognized.


CONCLUSIONS
Hh was shown to be related to the formation of MALT lymphoma and VEGF is suggested to play a role in this lymphoma.
Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. nakamuram@pharm.kitasato-u.ac.jp
M
M
Nakamura
H
H
Matsui
S Yamagata
SY
Murayama
T
T
Matsumoto
H
H
Yamada
S
S
Takahashi
K
K
Tsuchimoto
D000818:Animals; D016481:Helicobacter Infections / Q000150:complications*; D018247:Helicobacter heilmannii; D018442:Lymphoma, B-Cell, Marginal Zone / Q000209:etiology* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis / Q000502:physiology*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000032:analysis
D042461:Vascular Endothelial Growth Factor A; C467480:vascular endothelial growth factor A, mouse; D040301:Vascular Endothelial Growth Factor Receptor-2