FERMENT-INHIBITING SUBSTANCES IN TUBERCLE BACILLI : STUDIES ON FERMENT ACTION. XI.
1. Tubercle bacilli contain unsaturated fatty acids which, when saponified, have the property of inhibiting the action of trypsin and leucoprotease. 2. In proportion to their iodin value these soaps are more active as inhibiting agents than the soaps prepared from linseed, olive, and cod-liver oils. 3. The activity of the soaps is dependent on the presence of unsaturated carbon bonds. 4. Saturation of the soaps with iodin destroys their inhibiting action. 5. Soaps probably play an important part in the production of the condition known as caseation in tuberculosis.
Department of Pathology of the College of Physicians and Surgeons, Columbia University, New York.
J W
JW
Jobling
W
W
Petersen