More than a pipe dream: uncovering mechanisms of vascular lumen formation.
An unresolved question in vasculogenesis is how mammalian endothelial cells make lumens in developing vessels. In this issue of Developmental Cell, Strilic et al. present a comprehensive analysis of murine arterial lumen formation that defines cellular and molecular events required for lumen morphogenesis and argues against a previous paradigm of lumen formation.
Nelson
Kevin S
KS
Northwestern University, Department of Molecular Biology and Cell Biology, Evanston, IL 60208, USA.
Beitel
Greg J
GJ
D000818:Animals; D001011:Aorta / Q000254:growth & development*; D002450:Cell Communication; D004730:Endothelium, Vascular / Q000502:physiology*; D051379:Mice; D009024:Morphogenesis / Q000502:physiology*; D018919:Neovascularization, Physiologic / Q000502:physiology*