[Effect of levosimendan on B-type natriuretic peptide levels in patients with advanced heart failure: a meta-analysis].
OBJECTIVE
To conduct a meta-analysis of the effect of levosimendan on B-type natriuretic peptide (BNP) levels and evaluate the therapeutic effect of levosimendan on advanced heart failure.


METHODS
A meta-analysis was performed on the selected data to analyze the effect of levosimendan on BNP levels.


RESULTS
Levosimendan decreased BNP by a mean of 337.66 [95%CI (-296.30, -379.02)] pg/ml 24 h after the administration, and by 259.92 [95%CI (-195.76, -324.08)] pg/ml at 48 h, and by 123.09 [95%CI(-53.32,-195.86)] pg/ml at 1 week. Levosimendan resulted in improvements of the cardiac function by about 29%, 22%, and 10% at 24 h, 48 h and 1 week after the administration.


CONCLUSIONS
Levosimendan produces favorable effects on the cardiac functions and BNP levels.
Department of Anesthesiology, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China. xuzhongdong88@163.com
Zhong-dong
ZD
Xu
Wei-xiong
WX
He
Yi-fan
YF
Zhao
Shu-xuan
SX
Xia
Bo
B
He
Tao
T
Yang
De-xiong
DX
Cao
Shu-ling
SL
Peng
Jue
J
Li
Ming-hui
MH
Cao
D002316:Cardiotonic Agents / Q000627:therapeutic use*; D006333:Heart Failure / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D006835:Hydrazones / Q000627:therapeutic use*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011724:Pyridazines / Q000627:therapeutic use*; D000077464:Simendan
D002316:Cardiotonic Agents; D006835:Hydrazones; D011724:Pyridazines; D020097:Natriuretic Peptide, Brain; D000077464:Simendan