Outcomes of cataract surgery following radiation treatment for retinoblastoma.
OBJECTIVE
To report the outcomes after cataract extraction in eyes previously treated for retinoblastoma.


METHODS
We reviewed the medical records of consecutive patients treated with cataract extraction at our institution for radiation-induced cataract following retinoblastoma treatment between 1992 and 2007.


RESULTS
Twelve eyes of 11 patients were included. The median age at diagnosis of retinoblastoma was 7.4 months. The median quiescent interval before cataract surgery was 34.6 months (range, 17-240 months). All patients underwent limbal-based extracapsular cataract extraction with scleral-tunnel wound construction. Anterior vitrectomy and posterior capsulotomy were performed in 7 eyes; an intraocular lens was placed in 10 eyes. A laser capsulotomy was subsequently performed in 5 eyes. No postoperative complications occurred. One patient underwent a pars plana vitrectomy for vitreous hemorrhage and proliferative retinopathy 5 years after cataract extraction. The median follow-up after surgery was 6.0 years (range, 1.1-12.3 years). Final visual acuity was between 20/20 and 20/60 in 6 eyes, between 20/70 and 20/200 in 2 eyes, and worse than 20/200 in 4 eyes. No intraocular tumor recurrences or metastases occurred. Two patients developed secondary rhabdomyosarcomas; 1 patient succumbed to the disease.


CONCLUSIONS
Limbal-based cataract extraction in our series was not associated with tumor recurrence or metastasis. The optimal quiescent interval is not known; however, no tumor recurrences occurred in our series when a minimum 17-month quiescent period was achieved. Visual improvement was noted in every patient, although several patients only experienced modest gains.
Payne
John F
JF
Department of Pediatric Ophthalmology, Emory Eye Center, Emory University, Atlanta, Georgia, USA.
Hutchinson
Amy K
AK
Hubbard
G Baker
GB
Lambert
Scott R
SR
D000293:Adolescent; D002386:Cataract / Q000209:etiology*; D002387:Cataract Extraction; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D011878:Radiotherapy / Q000009:adverse effects*; D019572:Retinal Neoplasms / Q000532:radiotherapy*; D012175:Retinoblastoma / Q000532:radiotherapy*; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy; D055815:Young Adult