Bone mineral density in women using depot medroxyprogesterone acetate (DMPA) for at least 2 years compared to a control group: a cross sectional study.
OBJECTIVE
To compare the effect of long-term use of depot medroxyprogesterone acetate (DMPA) on bone mineral density (BMD) in Thai women compared to the control.


METHODS
A cross sectional study was conducted on Thai women of reproductive age who used DMPA (50 subjects) for contraception for at least 2 years and non-hormonal users (50 subjects). BMD was measured at the lumbar spine, femur and distal radius, and ulna.


RESULTS
There was significantly lower BMD at the lumbar spines in the DMPA group but there was no significant difference in BMD between groups at the femur distal radius, and ulna.


CONCLUSIONS
Long-term use of DMPA has a negative impact on lumbar spine BMD.
Pongsatha
Saipin
S
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand. spongsat@mail.med.cmu.ac.th
Ekmahachai
Molrudee
M
Chaovisitsaree
Somsak
S
Suntornlimsiri
Nuchanart
N
Morakote
Nuntana
N
D000293:Adolescent; D000328:Adult; D015519:Bone Density / Q000187:drug effects*; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000494:pharmacology*; D003430:Cross-Sectional Studies; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000494:pharmacology*; D055815:Young Adult
D003271:Contraceptive Agents, Female; D003692:Delayed-Action Preparations; D017258:Medroxyprogesterone Acetate