Modelling Parkinson's disease in Drosophila.
The recent discovery of a number of genes involved in familial forms of Parkinson's disease (PD) has moved the use of model genetic organisms to the frontline. One avenue holding tremendous potential to find therapies against human diseases is the use of intact living systems where complex biological processes can be examined. Despite key differences that need to be taken into account when using invertebrate models such as Drosophila, there are many advantages offered by this system. The rapid generation time and the ability to easily generate transgenic animals together with the variety of genetic tools to control temporal and spatial expression of any given gene makes the fly model a very attractive system to study human neurodegenerative disorders. In this review, we analyze how the use of fruit flies has revealed to be an excellent tool providing valuable insights into the current understanding of the molecular mechanisms involved in the progression of PD.
Botella
José A
JA
Institute of Zoology, University of Regensburg, Universitaetsstr. 31, 93040, Regensburg, Germany.
Bayersdorfer
Florian
F
Gmeiner
Florian
F
Schneuwly
Stephan
S
D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress / Q000235:genetics; D010300:Parkinson Disease / Q000235:genetics* / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D057057:Serine Proteases / Q000235:genetics / Q000378:metabolism; D013481:Superoxides / Q000737:chemistry; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism; D051844:alpha-Synuclein / Q000737:chemistry; D000099202:PTEN-Induced Putative Kinase
D029721:Drosophila Proteins; D017346:Protein Serine-Threonine Kinases; D057057:Serine Proteases; D013481:Superoxides; D044767:Ubiquitin-Protein Ligases; D051844:alpha-Synuclein; C534484:PINK1 protein, Drosophila; D000099202:PTEN-Induced Putative Kinase; C487430:park protein, Drosophila