[Second-line therapy of idiopathic detrusor overactivity. Sacral neuromodulation and botulinum toxin A].
The syndrome of idiopathic overactive bladder (I-OAB) impairs quality of life for the affected individuals. Conservative treatment options such as antimuscarinics are not always effective, and resulting side effects can lead the patient to stop treatment. In recently years, minimally invasive and reversible sacral neuromodulation and botulinum toxin A have become available. Currently, the approved treatment option for I-OAB that is recommended by the International Consultation on Incontinence is sacral neuromodulation by InterStim therapy. This article gives an overview of the present clinical evidence on the effectiveness and reliability of these two treatment modalities as well as the current significance of sacral neuromodulation and botulinum toxin A for the second-line treatment of adult I-OAB.
Klinik für Urologie, Universitätsklinikum, Tübingen.
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B
Amend
D
D
Castro-Diaz
E
E
Chartier-Kastler
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D
De Ridder
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K
Everaert
M
M
Spinelli
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P
van Kereebroeck
K-D
KD
Sievert
D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004599:Electric Stimulation Therapy; D006801:Humans; D058542:Implantable Neurostimulators; D007267:Injections; D009130:Muscle, Smooth / Q000187:drug effects; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D012445:Sacrococcygeal Region; D053201:Urinary Bladder, Overactive / Q000188:drug therapy / Q000628:therapy*
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A