Morinda citrifolia (noni) reduces cancer risk in current smokers by decreasing aromatic DNA adducts.
Quantitative determination of aromatic DNA adducts in peripheral blood lymphocytes (PBLs) of current smokers is an useful surrogate biomarker for the evaluation of environmental carcinogen exposure or chemopreventive intervention. In this study, we examined the impact of Tahitian Noni Juice (TNJ) on the aromatic DNA adducts of PBLs, before and after a 1-mo intervention, using (32)P postlabeling assay. Of 283 enrolled, 203 smokers completed the trial. Aromatic DNA adducts levels in all participants were significantly reduced by 44.9% (P < 0.001) after drinking 1 to 4 oz of TNJ for 1 mo. Dose-dependent analyses of aromatic DNA adduct levels showed reductions of 49.7% (P < 0.001) in the 1-oz TNJ group and 37.6% (P < 0.001) in the 4-oz TNJ group. Gender-specific analyses resulted in no significant differences in the 4-oz TNJ groups. Interestingly, the 1-oz TNJ group showed a reduction of 43.1% (P < 0.001) in females compared with 56.1% (P < 0.001) in males. The results suggest that drinking 1 to 4 oz of TNJ daily may reduce the cancer risk in heavy cigarette smokers by blocking carcinogen-DNA binding or excising DNA adducts from genomic DNA.
Wang
Mian-Ying
MY
College of Medicine at Rockford, University of Illinois Chicago, Rockford, Illinois 61107, USA. mianwang@uic.edu
Peng
Lin
L
Lutfiyya
May Nawal
MN
Henley
Eric
E
Weidenbacher-Hoper
Vicki
V
Anderson
Gary
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D016588:Anticarcinogenic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001628:Beverages / Q000009:adverse effects; D015415:Biomarkers / Q000097:blood; D018736:DNA Adducts / Q000032:analysis* / Q000097:blood; D005260:Female; D005638:Fruit / Q000009:adverse effects; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry; D008297:Male; D008519:Medicine, Traditional; D008875:Middle Aged; D032066:Morinda / Q000009:adverse effects; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis* / Q000097:blood; D012727:Sex Characteristics; D012907:Smoking / Q000009:adverse effects* / Q000097:blood; D055815:Young Adult
D016588:Anticarcinogenic Agents; D015415:Biomarkers; D018736:DNA Adducts; D011084:Polycyclic Aromatic Hydrocarbons