The Mayo Dysphagia Questionnaire-30: documentation of reliability and validity of a tool for interventional trials in adults with esophageal disease.
The aim of this study was to develop the Mayo Dysphagia Questionnaire-30 Day (MDQ-30), a tool to measure esophageal dysphagia, by adapting items from validated instruments for use in clinical trials, and assess its feasibility, reproducibility, and concurrent validity. Outpatients referred to endoscopy for dysphagia or seen in a specialty clinic were recruited. Feasibility testing was done to identify problematic items. Reproducibility was measured by test-retest format. Concurrent validity reflects agreement between information gathered in a structured interview versus the patients' written responses. The MDQ-30, a 28-item instrument, took 10 min (range = 5-30 min) to complete. Four hundred thirty-one outpatients [210 (49%) men; mean age = 61 years] participated. Overall, most concurrent validity kappa values for dysphagia were very good to excellent with a median of 0.78 (min 0.28, max 0.95). The majority of reproducibility kappa values for dysphagia were moderate to excellent with a median kappa value of 0.66 (min 0.07, max 1.0). Overall, concurrent validity and reproducibility kappa values for gastroesophageal reflux disease (GERD) symptoms were 0.81 (95% CI = 0.72, 0.91) and 0.66 (95% CI = 0.55, 0.77), respectively. Individual item percent agreement was generally very good to excellent. Internal consistency was excellent. We conclude that the MDQ-30 is an easy-to-complete tool to evaluate reliably dysphagia symptoms over the last 30 days.
McElhiney
Judith
J
Mayo Medical School, Mayo Clinic, Rochester, MN 55905, USA.
Lohse
Matthew R
MR
Arora
Amindra S
AS
Peloquin
Joanna M
JM
Geno
Debra M
DM
Kuntz
Melissa M
MM
Enders
Felicity B
FB
Fredericksen
Mary
M
Abdalla
Adil A
AA
Khan
Yulia
Y
Talley
Nicholas J
NJ
Diehl
Nancy N
NN
Beebe
Timothy J
TJ
Harris
Ann M
AM
Farrugia
Gianrico
G
Graner
Darlene E
DE
Murray
Joseph A
JA
Locke
G Richard
GR
Grothe
Rayna M
RM
Crowell
Michael D
MD
Francis
Dawn L
DL
Grudell
April M B
AM
Dabade
Tushar
T
Ramirez
Angelica
A
Alkhatib
MhdMaan
M
Alexander
Jeffrey A
JA
Kimber
Jessica
J
Prasad
Ganapathy
G
Zinsmeister
Alan R
AR
Romero
Yvonne
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016001:Confidence Intervals; D003679:Deglutition; D003680:Deglutition Disorders / Q000175:diagnosis* / Q000188:drug therapy; D004935:Esophageal Diseases / Q000175:diagnosis / Q000188:drug therapy; D005240:Feasibility Studies; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D015203:Reproducibility of Results; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult