VKORC1 haplotypes in five East-Asian populations and Indians.
OBJECTIVE
Warfarin, a widely prescribed oral anticoagulant, is used for the prevention of thromboembolism. Several polymorphisms in VKORC1 have been shown to be associated with warfarin dose requirements. The frequencies of these VKORC1 polymorphisms display population differences; however, this has not been examined in many populations. In this study, we examined VKORC1 polymorphisms in five East-Asian populations (Han Chinese, Indonesian, Filipino, Thai and Vietnamese) and Indians.


METHODS
A total of six SNPs in the VKORC1 gene (-1639G>A, 497T>G, 1173C>T, 1542T>G, 2255C>T and 3730G>A) were genotyped. Frequencies, linkage disequilibrium and haplotype structures of these six VKORC1 SNPs were analyzed.


RESULTS
Our data showed that 497T>G is only polymorphic in the Indian population. The 497G allele is very rare in the East-Asian populations (frequency < 1%). The remaining SNPs demonstrated high linkage disequilibrium and had similar frequencies and haplotype structures in all but the Indian population. The Indian population is mostly made up of the H7 haplotype (76%) while the rest of the recruited populations consisted of the H1 haplotype (> 80%).
Lee
Ming Ta Michael
MT
Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road, Section 2, NanKang, Taipei, Taiwan.
Chen
Chien-Hsiun
CH
Chuang
Hui-Ping
HP
Lu
Liang-Suei
LS
Chou
Ching-Heng
CH
Chen
Ying-Ting
YT
Liu
Chih-Yang
CY
Wen
Ming-Shien
MS
Lu
Jang-Jih
JJ
Chang
Chi-Feng
CF
Wu
Jer-Yuarn
JY
Chen
Yuan-Tsong
YT
D000483:Alleles; D000925:Anticoagulants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D044466:Asian People; D002681:China / Q000208:ethnology; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D007194:India / Q000208:ethnology; D007214:Indonesia / Q000208:ethnology; D015810:Linkage Disequilibrium; D006899:Mixed Function Oxygenases / Q000235:genetics*; D010597:Pharmacogenetics / Q000379:methods; D010679:Philippines / Q000208:ethnology; D020641:Polymorphism, Single Nucleotide; D044469:Racial Groups / Q000235:genetics; D013785:Thailand / Q000208:ethnology; D014744:Vietnam / Q000208:ethnology; D064417:Vitamin K Epoxide Reductases; D014859:Warfarin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use
D000925:Anticoagulants; D014859:Warfarin; D006899:Mixed Function Oxygenases; C578523:VKORC1 protein, human; D064417:Vitamin K Epoxide Reductases