Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression.
Neuropeptide Y (NPY) has been found to play a role in the pathomechanism of both anxiety and depression. Thus, NPY is a promising candidate in the investigation of the clinical phenotype of "anxious depression". Five NPY gene variants were investigated for an influence on antidepressant treatment response in a sample of 256 patients with depression. Additionally, NPY gene impact on amygdala activation during facial emotion processing was analyzed in a subsample of 35 depressed patients. Particularly in anxious depression, the less active NPY rs16147 -399C allele conferred slow response after 2weeks and failure to achieve remission after four weeks of treatment. The rs16147 C allele was further associated with stronger bilateral amygdala activation in response to threatening faces in an allele-dose fashion. The present results point towards a possible influence of functional NPY gene variation on antidepressant treatment response in anxious depression, potentially conveyed by altered emotional processing.
Dept. of Psychiatry, University of Muenster, Germany. katharina.domschke@ukmuenster.de
Katharina
K
Domschke
Udo
U
Dannlowski
Christa
C
Hohoff
Patricia
P
Ohrmann
Jochen
J
Bauer
Harald
H
Kugel
Peter
P
Zwanzger
Walter
W
Heindel
Jürgen
J
Deckert
Volker
V
Arolt
Thomas
T
Suslow
Bernhard T
BT
Baune
D000328:Adult; D000368:Aged; D000483:Alleles; D000679:Amygdala / Q000503:physiopathology; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D001931:Brain Mapping; D016009:Chi-Square Distribution; D003863:Depression / Q000188:drug therapy* / Q000235:genetics* / Q000503:physiopathology; D003866:Depressive Disorder / Q000188:drug therapy* / Q000235:genetics* / Q000503:physiopathology; D004644:Emotions / Q000502:physiology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000235:genetics*; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D016896:Treatment Outcome
D000928:Antidepressive Agents; D009478:Neuropeptide Y