Occurrence of coronary collateral vessels in patients with sleep apnea and total coronary occlusion.
BACKGROUND
Obstructive sleep apnea (OSA) is thought to act as a coronary risk factor. There is emerging evidence that intermittent phases of hypoxia might contribute to alterations of the cardiovascular system. We hypothesized that OSA syndrome (OSAS) might be accompanied by an increased coronary collateral vessel (CCV) development in patients with total coronary occlusion.


METHODS
Thirty-four patients with total coronary occlusions were classified according to the apnea-hypopnea index (AHI) (OSAS: AHI > 10/h; non-OSAS: AHI < 10/h). CCVs were scored by visual analysis and were analyzed according to the Cohen and Rentrop grading system.


RESULTS
There was no significant discrepancy between the groups concerning the prevalence of age, gender, the presence of hypertension, smoking, or diabetes mellitus. There was no difference in left ventricular systolic function (ejection fraction 53% +/- 20% vs 61% +/- 20%, P = .29) or left ventricular end-diastolic pressure (22.6 +/- 8.5 mm Hg vs 18.5 +/- 7.7 mm Hg, P = .41). OSAS showed a higher Rentrop score compared with non-OSAS (1.61 +/- 1.2 vs 2.4 +/- 0.7, P = .02).


CONCLUSIONS
These findings suggest that CCV development is augmented in patients with OSA.
Steiner
Stephan
S
Department of Cardiology, Pneumology, and Angiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. steinest@uni-duesseldorf.de
Schueller
Per Otto
PO
Schulze
Volker
V
Strauer
Bodo Eckehard
BE
D000368:Aged; D003097:Collateral Circulation; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010092:Oximetry; D017286:Polysomnography; D011379:Prognosis; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology