Synthesis of new heterometallic macromolecules: their DNA binding, cleavage activity and in vitro model electrochemotherapy study.
The homodinuclear C(16)H(30)N(8)O(5)Sn(2)Cl(4) (1), heterotetranuclear C(16)H(38)N(8)O(9)Sn(2)Cu(2)Cl(8) (2) and C(16)H(38)N(8)O(9)Sn(2)Mn(2)Cl(8) (3) macrocyclic complexes were synthesized and characterized by elemental analysis, spectroscopic techniques and molar conductance measurements. The interaction studies of 1-3 with calf thymus DNA (CT-DNA) were carried out by UV-vis titration, fluorescence, cyclic voltammetry and viscosity measurements. These results were further authenticated by carrying out interaction studies of 1-3 with plasmid pBR322 DNA employing gel electrophoresis. To overcome the dose resistance, auto toxicity of the drugs, a model study based on electrochemotherapy (ECT) was carried out and the results were compared in the presence and in the absence of the applied electrical potential.
Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India. tsartaj62@yahoo.com
Sartaj
S
Tabassum
Irshad-ul-Haq
IU
Bhat
Farukh
F
Arjmand
D000042:Absorption; D000818:Animals; D002417:Cattle; D004247:DNA / Q000378:metabolism*; D004358:Drug Therapy / Q000379:methods*; D004563:Electrochemistry / Q000379:methods*; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D005453:Fluorescence; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008670:Metals; D008956:Models, Chemical; D013055:Spectrophotometry, Infrared; D014783:Viscosity
D047028:Macrocyclic Compounds; D008670:Metals; D004247:DNA; C427203:calf thymus DNA