The changes of plasma malondialdehyde, nitric oxide, and adrenomedullin levels in patients with preeclampsia.
OBJECTIVE
The aim of the study was to investigate the role of malondialdehyde, nitric oxide and adrenomedullin in the etiopathogenesis of preeclampsia.


METHODS
Forty-two pregnant women with preeclampsia and 30 healthy pregnant women were involved. The plasma concentrations of malondialdehyde, nitric oxide, and adrenomedullin were compared between the study group and the control group.


RESULTS
In women with preeclampsia the plasma concentrations of malondialdehyde was higher while nitric oxide and adrenomedullin concentrations were lower compared to control subjects.


CONCLUSIONS
We concluded that the plasma levels of ADM and NO are decreased while MDA levels are increased in subjects with preeclampsia and that might contribute to the pathophysiology of preeclampsia through the lack of a paracrine vasodilatory effect on uteroplacental blood flow.
Dikensoy
Ebru
E
Obstetrics & Gynecology Department, Gaziantep University, School of Medicine, Gaziantep, Turkey. ebrudikensoy@yahoo.com
Balat
Ozcan
O
Pence
Sadrettin
S
Balat
Ayse
A
Cekmen
Mustafa
M
Yurekli
Muhuttin
M
D053607:Adrenomedullin / Q000097:blood*; D005260:Female; D006801:Humans; D008315:Malondialdehyde / Q000097:blood*; D009569:Nitric Oxide / Q000097:blood*; D018579:Patient Selection; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
D053607:Adrenomedullin; D009569:Nitric Oxide; D008315:Malondialdehyde