1,5-diazacyclohenicosane, a new cytotoxic metabolite from the marine sponge Mycale sp.
A new cyclic diamine, 1,5-diazacyclohenicosane (1), was isolated from samples of the marine sponge Mycale sp. collected at Lamu Island (Kenya). Its structure was determined by a combination of spectroscopic techniques, including (+)-HRESIMS and 1D and 2D NMR spectroscopy. The compound displayed cytotoxicity at the muM level against three human tumor cell lines.
Medicinal Chemistry Department, PharmaMar S.A.U., Pol. Ind. La Mina Norte, Avda de los Reyes 1, 28770-Colmenar Viejo (Madrid). Spain. lcoello@pharmamar.com
Laura
L
Coello
María Jesús
MJ
Martín
Fernando
F
Reyes
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006573:Heterocyclic Compounds, 1-Ring / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007630:Kenya; D011161:Porifera / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods
C546720:1,5-diazacyclohenicosane; D000970:Antineoplastic Agents; D006573:Heterocyclic Compounds, 1-Ring