Measurement and calculation of characteristic prompt gamma ray spectra emitted during proton irradiation.
In this paper, we present results of initial measurements and calculations of prompt gamma ray spectra (produced by proton-nucleus interactions) emitted from tissue equivalent phantoms during irradiations with proton beams. Measurements of prompt gamma ray spectra were made using a high-purity germanium detector shielded either with lead (passive shielding), or a Compton suppression system (active shielding). Calculations of the spectra were performed using a model of both the passive and active shielding experimental setups developed using the Geant4 Monte Carlo toolkit. From the measured spectra it was shown that it is possible to distinguish the characteristic emission lines from the major elemental constituent atoms (C, O, Ca) in the irradiated phantoms during delivery of proton doses similar to those delivered during patient treatment. Also, the Monte Carlo spectra were found to be in very good agreement with the measured spectra providing an initial validation of our model for use in further studies of prompt gamma ray emission during proton therapy.
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M D Anderson Cancer Center, Univeristy of Texas, Houston, TX 77030, USA. jcpolf@mdanderson.org
Peterson
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McCleskey
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Roeder
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Spiridon
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Beddar
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D003198:Computer Simulation; D005720:Gamma Rays / Q000627:therapeutic use; D006801:Humans; D008954:Models, Biological; D009010:Monte Carlo Method; D009369:Neoplasms / Q000503:physiopathology* / Q000532:radiotherapy*; D061766:Proton Therapy; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D011522:Protons
D011522:Protons