Association analysis of the IL-17F His161Arg polymorphism in myocardial infarction.
BACKGROUND
There is growing evidence that coronary atherosclerosis and its most severe phenotype, myocardial infarction (MI), are chronic inflammatory diseases. Interleukins are important mediators and modulators of inflammation. The His161Arg polymorphism in the gene encoding of IL-17F has recently been consistently found to be associated with chronic inflammatory disorders. In this study, we explored the hypothesis that the variant also affects the risk of MI.


METHODS
We conducted a case-control association study on a cohort of 513 unrelated MI patients and 477 age-matched and sex-matched controls in a Chinese Han population.


RESULTS
Differences in the genotype distributions and allele frequencies of this polymorphism between cases and controls were insignificant (P = 0.38 and 0.57, respectively). Further stratification for age, sex, the number of diseased coronary arteries, and other cardiovascular risk factors did not affect the negative findings.


CONCLUSIONS
This study indicates for the first time that, unlike other chronic inflammatory diseases, the IL-17F His161Arg polymorphism is unlikely to be a major contributor to the pathogenesis of MI.
Pei
Fang
F
Department of Cardiology, Northern Hospital, Shenyang, Liaoning Province, People's Republic of China.
Han
Yaling
Y
Zhang
Xiaolin
X
Yan
Chenghui
C
Huang
Mingfang
M
Deng
Jie
J
Kang
Jian
J
D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors
C440021:IL17F protein, human; D020381:Interleukin-17