THE CULTURE OF WHOLE ORGANS : III. THE PROBLEM OF ANTIHORMONES STUDIED ON ISOLATED LIVING THYROID GLANDS.
1. Perfusion of isolated thyroid glands from rabbits, made refractory to the action of the thyro-stimulating factor from the hypophysis by repeated injections for 2 months, has shown that in this condition the thyroid epithelium responds to pituitary stimulation. 2. The serum from refractory rabbits does not neutralize completely the thyro-stimulating effect of anterior pituitary extract upon an isolated normal thyroid gland. 3. It is believed that tissues other than the thyroid play a rôle in bringing about the phenomena which have been described as refractoriness against a prolonged action of the thyro-stimulating pituitary factor.
Okkels
H
H
Laboratories of The Rockefeller Institute for Medical Research.