Spectroscopic behavior and biological activity of K2[VO(O2)NTA].2H2O.
The dihydrated potassium salt of the complex anion [VO(O(2))NTA](2-) (NTA = nitrilotriacetate anion, [N(CH(2)-COO)(3)](3-)) was thoroughly characterized by electronic and vibrational (infrared and Raman) spectroscopies. The bioactivity of the complex on the cell proliferation was tested on three cell lines in culture (UMR106 rat osteosarcoma-derived cells, Caco-2 derived from a human colon adenocarcinoma, and RAW 264.7, a macrophage murine cell line).
Departamento Estrella Campos, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Gabriel
G
Arrambide
Daniel A
DA
Barrio
Susana B
SB
Etcheverry
Dinorah
D
Gambino
Enrique J
EJ
Baran
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018938:Caco-2 Cells; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D006801:Humans; D015394:Molecular Structure; D051381:Rats; D013057:Spectrum Analysis; D017968:Vanadium Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D017968:Vanadium Compounds