Catechol derivatives-coated Fe3O4 and gamma-Fe2O3 nanoparticles as potential MRI contrast agents.
Superparamagnetic iron oxide nanoparticles, Fe(3)O(4) and gamma-Fe(2)O(3), were produced by the so-called polyol process. In order to stabilize the particles in a physiological environment as potential contrast agents for Magnetic Resonance Imaging (MRI), the as-prepared particles were successfully transferred to an aqueous medium through ligand exchange chemistry of the adsorbed polyol species with the dopamine or the catechaldehyde. The ligands were able to participate in bidentate binding to the nanoparticles surface and to improve the stability of aqueous suspensions of the nanoparticles. Analysis was performed by various techniques including X-ray diffraction, transmission electron microscopy, infrared spectroscopy and thermal analysis. The results of magnetic measurements and initial in vitro magnetic resonance imaging essays are presented for the pre- and post-surface modified nanoparticles, respectively and discussed in relation with their structure and microstructure.
Basti
H
H
ITODYS, Université Paris 7-CNRS UMR 7086, 15, rue Jean-Antoine de Baïf, 75205 Paris Cedex 13, France.
Ben Tahar
L
L
Smiri
L S
LS
Herbst
F
F
Vaulay
M-J
MJ
Chau
F
F
Ammar
S
S
Benderbous
S
S
D001547:Benzaldehydes / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002396:Catechols / Q000737:chemistry*; D003102:Colloids / Q000737:chemistry; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D004298:Dopamine / Q000737:chemistry; D005026:Ethylene Glycols / Q000737:chemistry; D005290:Ferric Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000138:chemical synthesis / Q000737:chemistry*; D008027:Light; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D012542:Scattering, Radiation; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D017186:Titrimetry; D014961:X-Ray Diffraction
D001547:Benzaldehydes; D002396:Catechols; D003102:Colloids; D003287:Contrast Media; D005026:Ethylene Glycols; D005290:Ferric Compounds; C000499:ferric oxide; C005581:protocatechualdehyde; C013484:diethylene glycol; D004298:Dopamine; D052203:Ferrosoferric Oxide