Use of sodium thiosulfate in the treatment of calciphylaxis.
Calciphylaxis is an infrequent but severe entity found in chronic dialysis patients. Its clinical pattern consists of tissue ischemia with itchy and painful subcutaneous nodules and plaques, most often located on the abdomen, buttocks, thighs and/or legs. These injuries evolve to extensive superficial necrosis of the skin overlying the panniculitis, with ulceration, overinfection and consequent sepsis. Current treatment modalities used to counteract this pathology are not entirely effective. A new treatment reported for calciphylaxis, is the use of intravenous sodium thiosulfate. This inorganic salt is already used in the treatment of intoxication caused by cyanide, in patients with calcific nephrolithiasis and tumoral calcinosis, with very good and safe results. We herewith report a case of calciphylaxis that was cured using intravenous sodium thiosulphate treatment.
Department of Nephrology, Hospital Italiano de Buenos Aires, Argentina. carlosmusso@gmail.com
Carlos G
CG
Musso
Paula
P
Enz
Flavia
F
Vidal
Rodolfo
R
Gelman
Aldana
A
Lizarraga
Luis Di
LD
Giuseppe
Alicia
A
Kowalczuk
Leonardo
L
Garfi
Ricardo
R
Galimberti
Luis
L
Algranati
D002115:Calciphylaxis / Q000188:drug therapy* / Q000473:pathology; D002614:Chelating Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008875:Middle Aged; D006435:Renal Dialysis; D012867:Skin / Q000473:pathology; D013885:Thiosulfates / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D002614:Chelating Agents; D013885:Thiosulfates; C017717:sodium thiosulfate