Bromomaleimides: new reagents for the selective and reversible modification of cysteine.
Bromomaleimides react rapidly and selectively with cysteine to afford thiomaleimides which can be cleaved with a phosphine to regenerate the cysteine or treated with a base to afford dehydroalanine.
Tedaldi
Lauren M
LM
Department of Chemistry, University College London, 20 Gordon St, London, UK.
Smith
Mark E B
ME
Nathani
Ramiz I
RI
Baker
James R
JR
D001966:Bromine / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry*; D008301:Maleimides / Q000737:chemistry*
D007202:Indicators and Reagents; D008301:Maleimides; C043592:maleimide; D003545:Cysteine; D001966:Bromine