Genetic testing of the hypothesis that hybrid male lethality results from a failure in dosage compensation.
Several recent studies have suggested that F(1) hybrid male lethality in crosses between Drosophila melanogaster and D. simulans is due to a failure in dosage compensation, caused by incompatibilities between D. simulans dosage compensation proteins and the D. melanogaster X chromosome. Contrary to the predictions of this hypothesis, mutations in four essential D. melanogaster dosage compensation genes are shown here to moderately increase rather than decrease hybrid male viability.
Barbash
Daniel A
DA
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. dab87@cornell.edu
D000818:Animals; D003433:Crosses, Genetic; D003643:Death; D004303:Dosage Compensation, Genetic / Q000235:genetics*; D004331:Drosophila melanogaster / Q000145:classification / Q000235:genetics* / Q000502:physiology*; D005260:Female; D006824:Hybridization, Genetic / Q000235:genetics*; D008297:Male; D008957:Models, Genetic; D009154:Mutation; D015203:Reproducibility of Results; D014960:X Chromosome / Q000235:genetics