Investigation of triclosan retention and dental plaque viability with a triclosan/PVM/MA copolymer mouthrinse in a Thai population.
This investigation studied triclosan retention and plaque viability in a group of healthy human subjects from Bangkok, Thailand, 12 hours after using a mouthrinse containing a triclosan/PVM/MA copolymer system. The results show the retained triclosan in the dental plaque was with in or higher than the minimum inhibitory concentration (MIC range 0.27-6.25 microg/ml), indicating the triclosan in this product remains at an effective concentration in dental plaque. The 12-hour post-application evaluation demonstrated only 36.5% viability of oral bacteria in dental plaque after a one-time use of the mouthrinse. This study shows the benefits of using a mouthrinse containing a triclosan/PVM/MA copolymer system for providing 12 hours long-lasting anti-bacteria and dental plaque control.
Kraivaphan
Petcharat
P
Department of Pharmacology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. dtpvp@staff2.mahidol.ac.th
Amornchat
Cholticha
C
Laothumthut
Titikan
T
Triratana
Terdphong
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000493:pharmacokinetics; D001565:Benzoates / Q000493:pharmacokinetics*; D003773:Dental Plaque / Q000188:drug therapy* / Q000382:microbiology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000493:pharmacokinetics*; D011109:Polymethacrylic Acids / Q000493:pharmacokinetics; D011145:Polyvinyls / Q000493:pharmacokinetics; D012967:Sodium Dodecyl Sulfate / Q000493:pharmacokinetics*; D013785:Thailand; D014260:Triclosan / Q000493:pharmacokinetics*; D055815:Young Adult
D000891:Anti-Infective Agents, Local; D001565:Benzoates; D009067:Mouthwashes; C070868:Plax; D011109:Polymethacrylic Acids; D011145:Polyvinyls; C516721:poly(1-vinylimidazole-co-methyl methacrylate) copolymer; D012967:Sodium Dodecyl Sulfate; D014260:Triclosan