Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies.
Most cancer deaths result from spread of the primary tumor to distant sites (metastasis). MET is an important protein for metastasis in multiple tumor types. Here we report on the ability of tea catechins to suppress MET activation in human colon cancer cells and propose a mechanism by which they might compete for the kinase domain of the MET protein.
Larsen
Christine A
CA
Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA.
Bisson
William H
WH
Dashwood
Roderick H
RH
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D028241:Camellia sinensis; D002392:Catechin / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000494:pharmacology*; D005707:Gallic Acid / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D010636:Phenols / Q000494:pharmacology*; D059808:Polyphenols; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D019859:Proto-Oncogene Proteins c-met; D017978:Receptors, Growth Factor / Q000037:antagonists & inhibitors* / Q000737:chemistry; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D011518:Proto-Oncogene Proteins; D017978:Receptors, Growth Factor; D005707:Gallic Acid; D002392:Catechin; C491743:MET protein, human; D019859:Proto-Oncogene Proteins c-met