Reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase-9 are prognostic markers in skull base chordomas.
Prognosis of chordomas is difficult to predict based solely on histological findings. The purpose of this study was to assess expressions of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and matrix metalloproteinase (MMP)-2, MMP-9 in skull base chordomas and to find out their correlations to outcome. Immunohistochemical study was performed in 19 samples (initial, n = 11; recurrent, n = 8) from 11 patients. The correlations among expression of RECK, MMP-2, MMP-9, and their prognostic values were analyzed. Significant correlation between RECK and MMP-9 was found, but there was no correlation found between MMP-2 and MMP-9. Higher MMP-9 expression significantly influenced outcome. Furthermore, MMP-9/RECK ratio showed significant correlation to outcome, showing their inverse relationship in the disease progress of skull base chordoma. RECK and MMP-9 can be valuable markers to predict prognosis in skull base chordomas.
Department of Neurosurgery, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto 390-8621, Japan.
Nunung Nur
NN
Rahmah
Keiichi
K
Sakai
Jun
J
Nakayama
Kazuhiro
K
Hongo
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D002648:Child; D002817:Chordoma / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D005260:Female; D058851:GPI-Linked Proteins; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D019635:Neurosurgical Procedures; D011379:Prognosis; D019292:Skull Base Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed
D015415:Biomarkers; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; C115460:RECK protein, human; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9