The economies of synthesis.
In this tutorial review the economies of synthesis are analysed from both detailed and macroscopic perspectives, using case-studies from complex molecule synthesis. Atom, step, and redox economy are more than philosophical constructs, but rather guidelines, which enable the synthetic chemist to design and execute an efficient synthesis. Students entering the field of synthesis might find this tutorial helpful for understanding the subtle differences between these economic principles and also see real-world situations where such principles are put into practice.
Department of Chemistry, The Scripps Research Institute, 10550 N, Torrey Pines Road, La Jolla, CA 92037, USA.
Timothy
T
Newhouse
Phil S
PS
Baran
Reinhard W
RW
Hoffmann
D004467:Economics; D017408:Guidelines as Topic; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000191:economics; D010084:Oxidation-Reduction
D009930:Organic Chemicals