MRI contrast agent delivery using spore capsules: controlled release in blood plasma.
The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is slowly released in plasma due to enzymatic digestion of the capsule.
Lorch
Mark
M
Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK HU6 7RX.
Thomasson
Matthew J
MJ
Diego-Taboada
Alberto
A
Barrier
Sylvain
S
Atkin
Stephen L
SL
Mackenzie
Grahame
G
Archibald
Stephen J
SJ
D001704:Biopolymers / Q000737:chemistry*; D002338:Carotenoids / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D019786:Gadolinium DTPA / Q000097:blood / Q000737:chemistry*; D008279:Magnetic Resonance Imaging
D001704:Biopolymers; D003287:Contrast Media; D004337:Drug Carriers; C009800:sporopollenin; D002338:Carotenoids; D019786:Gadolinium DTPA