The impact of gender and hypothalamic pituitary adrenal activity on depressive symptoms following surgical stress.
The impact of gender and cortisol levels on depression following planned surgery was examined in 95 men and women. Patients were assessed prior to surgery and at one and three months following surgery. Higher cortisol levels conferred greater risk for depression at one and three months following surgery. This effect was stronger for men than women at one month following surgery, but did not differ between genders at three months post-surgery. Results support a mechanistic role of HPA alterations in depression following a surgical stressor that differs in strength between men and women.
Kent State University, OH, USA.
Keri
K
Pinna
Julie K
JK
Cremeans-Smith
Kenneth
K
Greene
Douglas L
DL
Delahanty
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001143:Arousal / Q000502:physiology*; D019645:Arthroplasty, Replacement, Knee / Q000523:psychology*; D003866:Depressive Disorder / Q000503:physiopathology* / Q000523:psychology; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000523:psychology; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D011183:Postoperative Complications / Q000503:physiopathology* / Q000523:psychology; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors
D006854:Hydrocortisone