The role of mitochondrial dysfunction and drug safety.
Mitochondria are the energy powerhouses of cells and are essential for cell survival. Evidence demonstrates that mitochondria are the off-targets of many drugs belonging to a diverse array of classes. This feature review discusses the mechanisms by which drugs impair mitochondrial function, and describes some of the high-throughput methods being used to screen for drug-induced mitochondrial impairment.
Pfizer Global R&D, Compound Safety Prediction, Worldwide Medicinal Chemistry, Eastern Point Road, Groton, CT 06340, USA. sashi.nadanaciva@pfizer.com
Sashi
S
Nadanaciva
Yvonne
Y
Will
D000818:Animals; D015195:Drug Design; D064420:Drug-Related Side Effects and Adverse Reactions; D057166:High-Throughput Screening Assays / Q000379:methods; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D028361:Mitochondrial Diseases / Q000139:chemically induced*; D018675:Toxicity Tests / Q000379:methods