An efficient one-pot synthesis of 2,3-epoxyl-1,3-diaryl-1-propanone directly from acetophenones and aromatic aldehydes under ultrasound irradiation.
A convenient and efficient one-pot synthesis of 2,3-epoxyl-1,3-diaryl-1-propanone directly from acetophenones and aromatic aldehydes under ultrasound irradiation at room temperature has been described. In comparison to two-step methods, the present procedure has the advantages of mild conditions, shorter reaction time, without isolation of any intermediate, saves energy and no requirement of toxic solvent.
Li
Ji-Tai
JT
College of Chemistry and Environmental Science, Hebei University, Baoding, PR China. lijitai@hbu.cn
Yin
Ying
Y
Sun
Ming-Xuan
MX
D000098:Acetophenones / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D001547:Benzaldehydes / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods; D004852:Epoxy Compounds / Q000138:chemical synthesis*; D006878:Hydroxides / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D017680:Potassium Compounds / Q000737:chemistry; D011407:Propane / Q000138:chemical synthesis*; D012997:Solvents / Q000737:chemistry; D013696:Temperature; D013997:Time Factors; D014465:Ultrasonics
D000098:Acetophenones; D000447:Aldehydes; D001547:Benzaldehydes; D004852:Epoxy Compounds; D006878:Hydroxides; D017680:Potassium Compounds; D012997:Solvents; D011407:Propane; C029943:potassium hydroxide