[Research progress in ARF-GEF gene family].
ARF-GEFs are a family of guanine-nucleotide exchange factors catalyzing the exchange of GDP for GTP on ADP-ribosylation factor. Large ARF-GEFs are highly conserved in all eukaryotes. It is an important regulator in both membrane dynamics and protein trafficking. Significant progress has been made in elucidating the structure, subcellular localization, and physiological functions of ARF-GEFs as a hot topic of cell biology recently. In this review, the character-istics and distribution of ARF-GEFs in different species, and recent research progress of ARF-GEFs and their regulation system are summarized.
State Key Laboratory of Plant Physiology and Biochemistry, College of Life Science, Zhejiang University, Hangzhou 310058, China. shipingliu@zju.edu.cn
Shi-Ping
SP
Liu
Lu
L
Wang
Yan-Hong
YH
Xue
Hui-Xia
HX
Shou
D020727:ADP-Ribosylation Factors / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D006056:Golgi Apparatus / Q000378:metabolism; D020662:Guanine Nucleotide Exchange Factors / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D010802:Phylogeny; D021381:Protein Transport / Q000502:physiology
D020662:Guanine Nucleotide Exchange Factors; D020727:ADP-Ribosylation Factors