The predicted protein structures of the novel DRB1*0717 and DRB1*0701 are highly related.
This article describes the identification of the novel human leukocyte antigen (HLA) allele DRB1*07 7 that was detected in a potential stem-cell donor of Caucasian origin. Compared to DRB1*070101, the new allele is characterized by a nonsynonymous nucleotide exchange of C-->T at position 201 in exon 2 replacing Arg by Trp in codon 72. As this sequence variation has not been seen earlier in any other HLA-DRB allele, it is most probably the result of a point mutation.
Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany.
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Wurm
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Tischer
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Immenschuh
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Blasczyk
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Eiz-Vesper
D000595:Amino Acid Sequence; D001483:Base Sequence; D019295:Computational Biology; D030562:Databases, Protein; D005544:Forecasting; D006684:HLA-DR Antigens / Q000737:chemistry* / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid; D040681:Structural Homology, Protein
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C456920:HLA-DRB1*07 antigen