The role of gene discovery, QTL analyses and gene expression in reproductive traits in the pig.
The reproductive performance of the sow is one of the key factors affecting production profitability of the pig industry. Reproductive traits are in general, lowly heritable, and with reliable markers, they can be used to enhance current selection procedures for improvement of these traits. To find potential markers, large scale quantitative trait loci (QTL) and candidate gene studies have been conducted for reproductive traits. The present review discusses QTL and candidate gene discovery, large scale SNP association studies, gene expression profiling and discovery of miRNA regulation of pig reproductive tissues. Many QTL have been found for reproduction traits and a limited number of useful genes (e.g.: ESR1, PRLR, FSHB, EPOR and RBP4) have been found to have significant associations with reproductive traits. Expression studies with reproductive tissues have revealed differential expression within a few gene networks which need further mapping and association analyses to select prospective gene markers. The near completion of the pig genome sequence and the development of high density SNP chips will allow for large scale SNP association studies for pig reproductive traits in the future. Collection of appropriate phenotypes in large numbers and in broad populations representative of the swine industry are required if such genomic studies will ultimately be successful.
Onteru
S K
SK
Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA, USA.
Ross
J W
JW
Rothschild
M F
MF
D000818:Animals; D020224:Expressed Sequence Tags; D005260:Female; D020869:Gene Expression Profiling; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D040641:Quantitative Trait Loci; D012098:Reproduction / Q000235:genetics*; D013552:Swine / Q000235:genetics*