Selective synthesis of 1-functionalized-alkyl-1H-indazoles.
An efficient method for the selective "N1" alkylation of indazoles is described. Use of alpha-halo esters, lactones, ketones, amides, and bromoacetonitrile provides good to excellent yield of the desired N1 products.
Hunt
Kevin W
KW
Array BioPharma Inc., 3200 Walnut Street, Boulder, Colorado 80301, USA. keVin.hunt@arraybiopharma.com
Moreno
David A
DA
Suiter
Nicole
N
Clark
Christopher T
CT
Kim
Ganghyeok
G
D000478:Alkylation; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D007191:Indazoles