Fluorescent detection of methylmercury by desulfurization reaction of rhodamine hydrazide derivatives.
Exposure to methylmercury causes severe damage to various tissues and organs in humans. Although a variety of fluorescent chemosensors have been exploited, only few biological monitoring systems for organomercury species have been described to date. In this report, we describe an irreversible rhodamine chemosensor for the detection of methylmercury and real-time monitoring of methylmercury in living cells and organisms.
Yang
Young-Keun
YK
Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
Ko
Sung-Kyun
SK
Shin
Injae
I
Tae
Jinsung
J
D000818:Animals; D002470:Cell Survival; D006367:HeLa Cells; D006801:Humans; D006834:Hydrazines / Q000737:chemistry*; D008767:Methylmercury Compounds / Q000032:analysis*; D012235:Rhodamines / Q000737:chemistry*; D012663:Semicarbazides / Q000138:chemical synthesis; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013455:Sulfur / Q000737:chemistry*; D017186:Titrimetry; D015027:Zebrafish / Q000378:metabolism
D006834:Hydrazines; D008767:Methylmercury Compounds; D012235:Rhodamines; D012663:Semicarbazides; C005151:thiosemicarbazide; D013455:Sulfur