Treatment of proximal femur infections with antibiotic-loaded cement spacers.
In case of periprosthetic hip infections the implantation of antibiotic-loaded PMMA spacers is accepted for an adequate treatment option. Although their indication for the treatment of destructive, bacterial infections of the proximal femur would make sense, literature data are scarce. Hence, the aim of this study was to evaluate the efficacy of antibiotic-impregnated spacers in the treatment of proximal femur infections. In 10 consecutive patients (5 M/ 5 F, mean age 66 y.) with bacterial proximal femur infections, a femoral head/neck resection was prospectively performed with a subsequent implantation of an antibiotic-loaded spacer. The joint-specific outcome was evaluated by the Merle d'Aubigne and the Mayo hip score, the general outcome by SF-36. The time periods were divided into "infection situation", "between stages" and meanly 1 year "after prosthesis implantation". The spacers were meanly implanted over 90 [155-744] days. In all cases an infection eradication could be achieved. After infection eradication, a prosthesis implantation was performed in 8 cases. The general scores showed significant increases at each time period. With regard to the dimension "pain", both scores demonstrated a significant increase between "infection situation" and "between stages", but no significance between "between stages" and "after prosthesis implantation". Spacers could be indicated in the treatment of proximal femur infections. Besides an infection eradication, a pain reduction is also possible.
Kelm
J
J
Klinik für Orthopädie und Orthopädische Chirurgie, Universitätskliniken des Saarlandes, Homburg/Saar, Germany. jk66421@hotmail.com
Bohrer
P
P
Schmitt
E
E
Anagnostakos
K
K
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019643:Arthroplasty, Replacement / Q000379:methods*; D001424:Bacterial Infections / Q000188:drug therapy*; D001843:Bone Cements / Q000737:chemistry / Q000627:therapeutic use*; D005260:Female; D005269:Femur / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D001843:Bone Cements