Clinical compliance with an oral uracil/tegafur (UFT) plus leucovorin (LV) regimen as adjuvant chemotherapy in Japanese colorectal cancer patients.
BACKGROUND
The combination of oral uracil/tegafur (UFT) plus leucovorin (LV) is widely accepted as adjuvant chemotherapy for stages II and III of colorectal cancer. However, the clinical compliance of Japanese patients with this regimen has not been clearly elucidated to date.


METHODS
A total of 40 Japanese outpatients were treated with oral UFT plus LV as adjuvant chemotherapy following colorectal cancer surgery between January 2005 and June 2007. UFT capsules (300-500 mg/body per day) and LV tablets (75 mg/body per day, administered with each dose of UFT) were to be taken for 28 days, followed by 7 days of rest, with this cycle repeated every 35 days for 6 months or until recurrence. The patients were classified into the following three groups based on compliance: the completed group (n = 21), the modified group (n = 12), and the discontinued group (n = 7).


RESULTS
The UFT doses (mean +/- SD) were 267 +/- 35 mg/m(2) in the completed group, 276 +/- 50 mg/m(2) in the modified group, and 288 +/- 22 mg/m(2) in the discontinued group. The UFT dose in the discontinued group tended to be higher than that in the completed group (P = 0.12). The most frequent symptoms of nonhematologic toxicity were appetite loss (45%) and fatigue (45%). There were no hematologic or nonhematologic toxicities of grade 3 or 4.


CONCLUSIONS
The regimen of oral UFT plus LV produced only low-grade toxicity and was convenient for outpatients. It appears that the initial UFT dose might be associated with the development of toxicity in the oral UFT plus LV regimen.
Meguro
Makoto
M
Department of Surgical Oncology and Gastroenterological Surgery, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo, Japan. meguro@sapmed.ac.jp
Furuhata
Tomohisa
T
Okita
Kenji
K
Nishidate
Toshihiko
T
Ishiyama
Gentaro
G
Iwayama
Yuji
Y
Kimura
Yasutoshi
Y
Mizuguchi
Toru
T
Hirata
Koichi
K
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D044466:Asian People; D002214:Capsules; D017024:Chemotherapy, Adjuvant; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000208:ethnology / Q000601:surgery*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D013607:Tablets; D005641:Tegafur / Q000008:administration & dosage; D016896:Treatment Outcome
D000964:Antimetabolites, Antineoplastic; D002214:Capsules; D013607:Tablets; D005641:Tegafur; D002955:Leucovorin