A case of endocarditis of difficult diagnosis in dialysis: could "pest" friends be involved?
We report a case of A. xylosoxidans endocarditis of larvate clinical presentation in a central venous catheter-dependent hemodialysis patient of difficult diagnosis and poor evolution despite a high index of suspicion and consequent assessment. A 50-year-old man on hemodialysis presented with inflammatory-malnutrition parameters during the months prior to diagnosis of endocarditis, whilst he was otherwise asymptomatic. No vegetations were detectable on his cardiac valves at repeated echocardiography until third transesophageal echocardiography was performed, and confirmed intraoperatively. On the occasion of positive peripheral blood culture for Alcaligenes (Achromobacter) xylosoxidans, the etiological diagnosis was retrospectively explained given his history of animal exposure - hunting rabbits using his pet ferrets. This bacterium is an emergent and resistant organism, mostly related to nosocomial infections and environmental water sources. Reservoirs include the microflora of the nasal cavity of rabbits and the dentogingival sulcus of ferrets. We presume that A. xylosoxidans endocarditis was transmitted from the patient's pets. It highlights the importance of early recognition of an inflammatory status and investigation of the underlying cause. Additionally, the causative bacterium emphasizes the importance of registering exposure to animals in CVC-dependent patients as well as the need for their awareness of hygienic precautions and the infectious risk associated to catheters.
Department of Nephrology, Hospital Perpetuo Socorro, Alicante, Spain. tamaramalek@gmail.com
T
T
Malek-Marín
M D
MD
Arenas
M
M
Perdiguero
M
M
Salavert-Lleti
A
A
Moledous
E
E
Cotilla
M T
MT
Gil
D042441:Achromobacter denitrificans; D000818:Animals; D055499:Catheter-Related Infections / Q000175:diagnosis / Q000382:microbiology*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002408:Catheters, Indwelling / Q000009:adverse effects; D004697:Endocarditis, Bacterial / Q000175:diagnosis* / Q000209:etiology / Q000382:microbiology; D005289:Ferrets / Q000382:microbiology; D016905:Gram-Negative Bacterial Infections / Q000175:diagnosis* / Q000382:microbiology / Q000635:transmission; D006801:Humans; D008297:Male; D008875:Middle Aged; D011817:Rabbits / Q000382:microbiology; D006435:Renal Dialysis