Inhibitory effect of curcumin on liver injury in a murine model of endotoxemic shock.
The effect of curcumin on lipopolysaccharide/D: -galactosamine (LPS/GalN)-induced acute shock model of liver injury was examined in mice. The simultaneous administration of LPS (5-20 microg kg(-1), i.p.) and GalN (700 mg kg(-1), i.p.) markedly increased the serum tumor necrosis factor-alpha (TNF-alpha), glutamic oxaloacetic transaminase/glutamic pyruvic transaminase (GOT/GPT), and massive hepatic necrosis and inflammation, leading to 100% lethality. Pre-administration of curcumin (100 mg kg(-1), i.p.) 3 h before induction with LPS/GalN imparted a large extent of protection against acute elevation in serum TNF-alpha and serum GOT/GPT. Hepatic necrosis and lethality caused by LPS/GalN was also greatly reduced by curcumin treatment. The results demonstrated that curcumin could protect mice from LPS/GalN-induced hepatic injury and inflammation through blockading TNF-alpha production, eventually raising the survival rate of septic-shock-induced mice.
Department of Biological Science, Ajou University, Suwon 443-749, Republic of Korea.
Sang Sik
SS
Yun
Sung Phil
SP
Kim
Mi Young
MY
Kang
Seok Hyun
SH
Nam
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000378:metabolism / Q000517:prevention & control*; D003474:Curcumin / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008070:Lipopolysaccharides; D051379:Mice; D008807:Mice, Inbred BALB C; D012772:Shock, Septic / Q000175:diagnosis* / Q000378:metabolism / Q000517:prevention & control*; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D003474:Curcumin