Intake of 1-deoxynojirimycin suppresses lipid accumulation through activation of the beta-oxidation system in rat liver.
It was recently shown that administration of 1-deoxynojirimycin (DNJ) extracted from mulberry suppresses an increase in postprandial blood glucose in humans. These findings are of interest, but other physiological functions of DNJ are unknown. This study examined the effects of oral administration of DNJ (1 mg/kg of body weight/day) or mulberry extracts enriched in DNJ (meDNJ; 100 or 200 mg of extract/kg of body weight/day, equivalent to 0.53 or 1.06 mg of DNJ/kg of body weight/day) in male Sprague-Dawley rats for 4 weeks. DNJ and meDNJ enhanced expression of adiponectin mRNA in white adipose tissue; increased plasma adiponectin levels, enhanced expression of AMPK mRNA, activated the beta-oxidation system, and suppressed lipid accumulation in the liver. Intake of DNJ and meDNJ did not cause hepatic dysfunction and led to a reduction of oxidative stress. These results indicate the efficacy and safety of DNJ and meDNJ.
Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University, Sendai, Japan. tsuzukit@biochem.tohoku.ac.jp
Tsuyoshi
T
Tsuduki
Yumiko
Y
Nakamura
Taro
T
Honma
Kiyotaka
K
Nakagawa
Toshiyuki
T
Kimura
Ikuo
I
Ikeda
Teruo
T
Miyazawa
D017485:1-Deoxynojirimycin / Q000008:administration & dosage*; D052242:Adiponectin / Q000097:blood / Q000235:genetics; D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005227:Fatty Acids / Q000378:metabolism; D005638:Fruit / Q000737:chemistry; D015870:Gene Expression / Q000187:drug effects; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D031625:Morus / Q000737:chemistry; D010084:Oxidation-Reduction; D010936:Plant Extracts / Q000008:administration & dosage; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley
D052242:Adiponectin; D001786:Blood Glucose; D005227:Fatty Acids; D010936:Plant Extracts; D012333:RNA, Messenger; D017485:1-Deoxynojirimycin