Bone regeneration: the stem/progenitor cells point of view.
After bone injuries, several molecular mechanisms establish bone repair from stem/progenitor cells. Inflammation factors attract regenerative cells which expand and differentiate in order to build up a bone highly similar to that before injury. Bone marrow (BM) mesenchymal stem cells (MSCs) as skeletal stem cells and endothelial progenitors (EPCs) are at the origin of such reparation mechanisms. However, discrepancies exist about their identities. Although cultured MSCs are extensively described, their in vivo native forms are poorly known. In addition, recent experiments show that several types of EPC exist. We therefore review up-to-date data on the characterization of such stem/progenitor cells and propose a new point of view of their function in bone regeneration.
Etablissement Français du Sang Centre-Atlantique, Groupe de Recherche sur les Cellules Souches Mésenchymateuses (GECSoM), Tours, France. frederic.deschaseaux@efs.sante.fr
Frédéric
F
Deschaseaux
Charalampos
C
Pontikoglou
Luc
L
Sensébé
D015415:Biomarkers / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology / Q000502:physiology*; D001861:Bone Regeneration / Q000502:physiology*; D018929:Cell Culture Techniques; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage; D049109:Cell Proliferation; D002478:Cells, Cultured; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology*; D018919:Neovascularization, Physiologic; D009432:Neural Crest / Q000166:cytology; D010012:Osteogenesis / Q000502:physiology; D010641:Phenotype
D015415:Biomarkers