Electrocorticogram changes during corpus callosotomy for uncontrolled symptomatic generalized epilepsy.
We report a 19-year-old man who presented to our facility with medically intractable, symptomatic generalized epilepsy manifesting as generalized tonic-clonic seizures (GTCs). Before he underwent an anterior callosotomy (6 cm), these seizures, which he had experienced for 11 years, seemed to have a left-sided focal origin. Intraoperatively, no epileptiform discharges were found on the electrocorticogram (ECoG) performed prior to sectioning, but more than 10 left-sided seizures were recorded after sectioning. In the 10 years since surgery, the patient's seizures have remained generalized; however, the frequency and severity of the seizures have decreased. These findings indicate that the presence of electrocorticographic seizures, as measured by ECoG immediately following callosotomy, may not predict a poor surgical outcome, even though such a finding might be indicative of epileptogenicity in general.
Section of Neurology, Department of Medicine, Armed Forces Taoyuan General Hospital, Tao-Yuan County, Taiwan.
Hann-Yeh
HY
Shyu
Ji-Ho
JH
Lin
Shang-Yeong
SY
Kwan
Kai-Ping
KP
Chang
Chun-Hing
CH
Yiu
Tai-Tong
TT
Wong
D000200:Action Potentials / Q000502:physiology; D019771:Axotomy; D003337:Corpus Callosum / Q000033:anatomy & histology / Q000503:physiopathology / Q000601:surgery*; D003714:Denervation; D004569:Electroencephalography; D004829:Epilepsy, Generalized / Q000503:physiopathology* / Q000601:surgery*; D005071:Evoked Potentials / Q000502:physiology*; D005625:Frontal Lobe / Q000503:physiopathology; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D016343:Monitoring, Intraoperative; D009434:Neural Pathways / Q000033:anatomy & histology / Q000503:physiopathology / Q000601:surgery; D009474:Neurons / Q000502:physiology; D019635:Neurosurgical Procedures / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis; D012640:Seizures / Q000503:physiopathology / Q000601:surgery; D016896:Treatment Outcome; D055815:Young Adult