Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety.
A series of new alpha,beta-unsaturated conjugated ketones containing ferrocenyl pyrazole unit were synthesized and fully characterized by IR and NMR spectroscopy. Electrochemical characterization of subject compounds was performed by means of cyclic voltametry. The in vitro cytotoxic activity of all the synthesized compounds was studied against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines by the MTT method. Derivative 1l containing 3-pyridyl moiety exhibited a better cytotoxic activity in the cell growth inhibition of K562 cell lines in comparison with cisplatin as a reference compound.
Ratković
Zoran
Z
Faculty of Sciences, University of Kragujevac, R. Domanovica 12, 34000 Kragujevac, Serbia.
Juranić
Zorica D
ZD
Stanojković
Tatjana
T
Manojlović
Dragan
D
Vukićević
Rastko D
RD
Radulović
Niko
N
Joksović
Milan D
MD
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D002599:Chalcone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D055664:Electrochemical Techniques; D005296:Ferrous Compounds / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D000075163:Metallocenes; D011720:Pyrazoles / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D000970:Antineoplastic Agents; D005296:Ferrous Compounds; D000075163:Metallocenes; D011720:Pyrazoles; D002599:Chalcone; C004998:ferrocene