The utility of comparative genetics to inform breast cancer prevention strategies.
My research seeks to aid in developing approaches to prevent breast cancer. This research evolved from our early empirical studies for discovering natural compounds with anticancer activities, coupled with clinical evaluation to a genetics-driven approach to prevention. This centers on the use of comparative genomics to discover risk-modifying alleles that could help define population and individual risk and also serve as potential prevention drugable targets to mitigate risk. Here, we initially fine map mammary cancer loci in a rat carcinogenesis model and then evaluate their human homologs in breast cancer case-control association studies. This approach has yielded promising results, including the finding that the compound rat QTL Mcs5a's human homologous region was associated with breast cancer risk. These and related findings have the potential to yield advancements both in translation-prevention research and in basic molecular genetics.
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, USA. gould@oncology.wisc.edu
Michael N
MN
Gould
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control*; D002874:Chromosome Mapping; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods*; D023281:Genomics / Q000379:methods*; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D011315:Preventive Medicine / Q000379:methods; D040641:Quantitative Trait Loci / Q000235:genetics; D051381:Rats