Formation of highly selective and efficient interstrand cross-linking to thymine without photo-irradiation.
Interstrand cross-linking (ICL) forming oligodeoxynucleotides (ODNs) have been expected to ensure the inhibition of gene expression. In this communication, we report a highly efficient and selective ICL reaction to thymine using a 4-amino-2-vinyl-6-oxopyrimidine derivative.
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai-shi, Miyagi, 980-8577, Japan.
Keiichi
K
Hattori
Tomoya
T
Hirohama
Shuhei
S
Imoto
Shuhei
S
Kusano
Fumi
F
Nagatsugi