A new tool linking human cytomegalovirus drug resistance mutations to resistance phenotypes.
Drug resistant strains of human cytomegalovirus (HCMV) in patients at risk may increasingly develop into a problem in the clinical setting. Genotypic resistance testing is becoming the method of choice, but requires previous phenotypic characterisation of each newly found mutation. In order to facilitate the interpretation of the patient's CMV sequence data, a web-based search tool was generated that links the sequence to a database containing all published UL97 (protein kinase) and UL54 (DNA polymerase) mutations and corresponding antiviral drug susceptibility phenotypes. It is reasonable to assume that HCMV drug resistance testing will provide relevant data for an adjustment of therapy and on prognosis of clinical outcome. HCMV drug susceptibility testing will become even more important once new drugs will be available for therapy allowing a wider choice of antiviral agents to treat HCMV disease. These topics will also play a pivotal role for optimising antiviral therapy of HCMV- and other viral diseases.
Chevillotte
Meike
M
Institute of Virology, University Hospital Ulm, D-89081 Ulm, Germany.
von Einem
Jens
J
Meier
Benjamin M
BM
Lin
Feng-Mao
FM
Kestler
Hans A
HA
Mertens
Thomas
T
D019943:Amino Acid Substitution; D003587:Cytomegalovirus / Q000187:drug effects* / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics*; D016208:Databases, Factual; D030541:Databases, Genetic; D030561:Databases, Nucleic Acid; D024882:Drug Resistance, Viral; D005838:Genotype; D006801:Humans; D020407:Internet; D020125:Mutation, Missense; D010641:Phenotype; D014764:Viral Proteins / Q000235:genetics*
D004279:DNA, Viral; D014764:Viral Proteins