Cosignaling molecules around LIGHT-HVEM-BTLA: from immune activation to therapeutic targeting.
The regulation of the immune system at the cell surface is primarily controlled by two families of cosigaling molecules: the immunoglobulin (Ig) superfamily, or "CD28 and B7 family", and the tumor necrosis factor receptor (TNFR) family. Here, we summarized the principal structural and functional characteristics of both families. In this respect, the interaction between HVEM, a TNF receptor, and BTLA, an Ig family member, has provided a new perspective and an additional level of complexity in the crosstalk between these two regulatory systems. This review will present a summary of the recent advances in the immunobiology of the LIGHT-HVEM-LTbetaR-BTLA network. The LIGHT-HVEM-BTLA system has emerged as a major regulator of immune responses and lymphocyte activation, whereas LIGHT-LTbetaR participates in lymphoid tissue development and cell death. Moreover, recent studies have provided encouraging new insights into the roles of the LIGHT-HVEM-LTbetaR-BTLA axis as a potential target for controlling anti-tumor responses.
INSERM UMR891, Centre de Recherche en Cancérologie de Marseille, Université de la Méditerranée, IFR 137 Institut de Cancérologie et d'Immunologie de Marseille, 27 Bd. Leï Roure, 13009 Marseille, France.
Christine
C
Pasero
Alemseged
A
Truneh
Daniel
D
Olive
D056704:Adaptive Immunity / Q000276:immunology; D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D018106:CD28 Antigens / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D060945:Inducible T-Cell Co-Stimulator Ligand; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology; D053259:Lymphotoxin beta Receptor / Q000276:immunology; D009369:Neoplasms / Q000276:immunology / Q000473:pathology; D011971:Receptors, Immunologic / Q000276:immunology*; D018124:Receptors, Tumor Necrosis Factor / Q000276:immunology; D053240:Receptors, Tumor Necrosis Factor, Member 14 / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D053326:Tumor Necrosis Factor Ligand Superfamily Member 14 / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D015703:Antigens, CD; C482586:BTLA protein, human; D018106:CD28 Antigens; C498514:ICOSLG protein, human; D060945:Inducible T-Cell Co-Stimulator Ligand; D053259:Lymphotoxin beta Receptor; D011971:Receptors, Immunologic; D018124:Receptors, Tumor Necrosis Factor; D053240:Receptors, Tumor Necrosis Factor, Member 14; D053326:Tumor Necrosis Factor Ligand Superfamily Member 14; D014409:Tumor Necrosis Factor-alpha