Drug release from lipid liquid crystalline phases: relation with phase behavior.
BACKGROUND
We studied the release of propranolol hydrochloride (PHCl), a water-soluble amphiphilic drug, from monoolein (MO)/water and phytantriol/water systems.


METHODS
We related the dissolution profiles with phase behavior and viscosity of the different liquid crystalline phases. Diolein has been added aiming to stabilize the cubic phases and thus preventing formation of less viscous (lamellar) phases.


RESULTS
Formulations display first-order release rates and diffusion release mechanism. Some formulations (mostly MO) were close to zero-order release in the first 120 minutes.


CONCLUSIONS
Release mechanism can be influenced by phase changes during dissolution.


CONCLUSIONS
Both MO and phytantriol show good potential to be used for propranolol hydrochloride sustained drug release.
Centro de Estudos Farmacêuticos, Laboratório de Galénica e Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade de Coimbra, Coimbra, Portugal. fatima.costa@infarmed.pt
Fátima O
FO
Costa-Balogh
Emma
E
Sparr
João José Simões
JJ
Sousa
Alberto Canelas
AC
Pais
D000284:Administration, Oral; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000737:chemistry; D003692:Delayed-Action Preparations; D004058:Diffusion; D016503:Drug Delivery Systems; D005233:Fatty Alcohols / Q000737:chemistry*; D005989:Glycerides / Q000737:chemistry*; D050866:Liquid Crystals; D044367:Phase Transition; D011433:Propranolol / Q000008:administration & dosage* / Q000737:chemistry*; D013678:Technology, Pharmaceutical
D000319:Adrenergic beta-Antagonists; D003692:Delayed-Action Preparations; D005233:Fatty Alcohols; D005989:Glycerides; C508873:3,7,11,15-tetramethyl-1,2,3-hexadecanetriol; D011433:Propranolol; C005953:monoolein