Preparation of a stable trifluoroborate salt for the synthesis of 1-aryl-2,2-difluoro-enolethers and/or 2,2-difluoro-1-aryl-ketones via palladium-mediated cross-coupling.
A bench-stable potassium trifluoroborate enol ether reagent has been prepared. This reagent is suitable for the incorporation of 2,2-difluoroenolethers into aryl and heteroaryl systems via palladium-mediated cross-coupling with suitable halide coupling partners.
Department of Chemistry, Merck and Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA. jason_katz2@merck.com
Jason D
JD
Katz
Blair T
BT
Lapointe
Christopher J
CJ
Dinsmore
D001881:Borates / Q000737:chemistry*; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D012492:Salts / Q000737:chemistry; D013237:Stereoisomerism
D001881:Borates; D004987:Ethers; D007659:Ketones; D012492:Salts; D010165:Palladium