[Bone quality markers: pentosidine, homocysteine, and MTHFR polymorphism].
Bone quality is thought to encompass the structural and material properties of bone that are affected by the turnover rate. Evidence has accumulated that collagen cross-links play important roles in bone strength. We have demonstrated that the quantitative and qualitative deterioration of lysyl oxidase control and non enzymatic cross-links (advanced glycation end products, AGEs, pentosidine) of collagen in patients with osteoporotic femoral neck fracture might be affected by hyperhomocysteinemia, oxidative stress, and vitamin B6 insufficiency. Recently, Shiraki et al. demonstrated that a functional polymorphism in methylenetetrahydrofolate reductase (MTHFR) polymorphism, T allele (C677T), may be a risk factor for future fracture in addition to the traditional risk factors. Further, we reported that a higher urinary pentosidine level was an independent risk factor for vertebral fracture in a 5-year prospective study involving Japanese women. If confirmed in large, prospective trials, measurements of serum homocysteine and serum or urine levels of pentosidine might be characterized as markers reflecting bone collagen deterioration.
Department of Orthopedic Surgery, Jikei University School of Medicine, Minato-ku, Tokyo 105-8461, Japan. xlink67@gol.com
Mitsuru
M
Saito
D001120:Arginine / Q000031:analogs & derivatives* / Q000032:analysis; D015415:Biomarkers / Q000032:analysis*; D005260:Female; D006710:Homocysteine / Q000032:analysis*; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000032:analysis; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D010024:Osteoporosis / Q000378:metabolism*; D011110:Polymorphism, Genetic
D015415:Biomarkers; D006710:Homocysteine; D001120:Arginine; C062187:pentosidine; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D008239:Lysine