[Primary Burkitt lymphoma of the seminal vesicle: a case report and review of the literature].
OBJECTIVE
To investigate the clinicopathological features of primary Burkitt lymphoma of the seminal vesicle.


METHODS
We reported the clinical characteristics, histological changes and the results of immunohistochemical staining and molecular in situ hybridization of 1 case of primary Burkitt lymphoma of the seminal vesicle. We also reviewed the related literature and studied the pathomorphological characteristics and differential diagnosis of the tumor.


RESULTS
The characteristic manifestations of the patient were frequent micturition with dysuria, followed by inguinal lymphadenectasis 2 months later. Medical imaging showed a diffuse and monotonous infiltration of neoplastic cells with scanty cytoplasm and a few mitosis images. Microscopy displayed a starry sky pattern. The tumor cells were positive for CD10, CD20, CD79alpha, Bcl-6 and EBER in situ hybridization, but negative for CD3, CD6 and Cyclin D1. The Ki-67 index was > 95%.


CONCLUSIONS
Primary Burkitt lymphoma of the seminal vesicle is a very rare tumor with aggressive behavior. The pathological diagnosis of the tumor depends on histopathological examination and immunohistochemical techniques. However it should be differentiated from diffuse large B-cell lymphoma, lymphoblastic lymphoma and small cell carcinoma of the seminal vesicle or prostate gland.
Department of Pathology, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
Jun
J
Ouyang
Hong-Lin
HL
Yin
Zhen-Feng
ZF
Lu
Hang-Bo
HB
Zhou
Xiao-Jun
XJ
Zhou
D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D005834:Genital Neoplasms, Male; D006801:Humans; D008297:Male; D008875:Middle Aged; D012669:Seminal Vesicles / Q000473:pathology*