EXPERIMENTAL NEPHRITIS IN RATS INDUCED BY INJECTION OF ANTI-KIDNEY SERUM : IV. PREVENTION OF THE INJURIOUS EFFECTS OF NEPHROTOXIN IN VIVO BY KIDNEY EXTRACT.
A saline extract of perfused rat kidney administered intravenously to rats immediately before injecting an anti-rat-kidney serum, by the same route, prevents renal damage. A preliminary injection of physiological salt solution or of an extract of perfused rat liver has no preventive effect. These findings are a further indication that the nephrotoxic effect induced by anti-kidney serum is dependent upon a relatively organ specific antibody, nephrotoxin.
Hospital of The Rockefeller Institute for Medical Research.
H F
HF
Swift
J E
JE
Smadel