Cortistatin A is a high-affinity ligand of protein kinases ROCK, CDK8, and CDK11.
Cee
Victor J
VJ
Department of Medicinal Chemistry, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. vcee@amgen.com
Chen
David Y-K
DY
Lee
Matthew R
MR
Nicolaou
K C
KC
D000818:Animals; D001665:Binding Sites; D002460:Cell Line; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D056850:Cyclin-Dependent Kinase 8 / Q000737:chemistry* / Q000378:metabolism; D018844:Cyclin-Dependent Kinases / Q000737:chemistry* / Q000378:metabolism; D057166:High-Throughput Screening Assays; D006801:Humans; D007546:Isoquinolines / Q000737:chemistry*; D008024:Ligands; D011083:Polycyclic Compounds / Q000737:chemistry*; D011161:Porifera / Q000737:chemistry; D017434:Protein Structure, Tertiary; D054460:rho-Associated Kinases / Q000737:chemistry* / Q000378:metabolism
D007546:Isoquinolines; D008024:Ligands; D011083:Polycyclic Compounds; C531521:cortistatin A; D054460:rho-Associated Kinases; C447612:CDK11a protein, human; D056850:Cyclin-Dependent Kinase 8; D018844:Cyclin-Dependent Kinases