Rare earth complexes with 3-carbaldehyde chromone-(benzoyl) hydrazone: synthesis, characterization, DNA binding studies and antioxidant activity.
A new ligand, 3-carbaldehyde chromone-(benzoyl) hydrazone (L), was prepared by condensation of 3-carbaldehyde chromone with benzoyl hydrazine. Its four rare earth complexes have been prepared and characterized on the basis of elemental analyses, molar conductivities, mass spectra, (1)H NMR spectra, UV-vis spectra, fluorescence studies and IR spectra. The Sm(III) complex exhibits red fluorescence under UV light and the fluorescent properties of Sm(III) complex in solid state and different solutions were investigated. In addition, the DNA binding properties of the ligand and its complexes have been investigated by electronic absorption spectroscopy, fluorescence spectra, ethidium bromide displacement experiments, iodide quenching experiments, salt effect and viscosity measurements. Experimental results suggest that all the compounds can bind to DNA via an intercalation binding mode. Furthermore, the antioxidant activities of the ligand and its complexes were determined by superoxide and hydroxyl radical scavenging methods in vitro. The rare earth complexes were found to possess potent antioxidant activities that are better than those of the ligand alone.
Li
Yong
Y
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Yang
Zheng-Yin
ZY
D000042:Absorption; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D002417:Cattle; D002867:Chromones / Q000737:chemistry*; D004247:DNA / Q000378:metabolism*; D004583:Electrons; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D006835:Hydrazones / Q000737:chemistry*; D017665:Hydroxyl Radical / Q000737:chemistry; D008024:Ligands; D008674:Metals, Rare Earth / Q000737:chemistry*; D015335:Molecular Probes / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D013057:Spectrum Analysis; D013481:Superoxides / Q000737:chemistry; D014783:Viscosity
C549153:3-carbaldehyde chromone-(benzoyl) hydrazone; D000970:Antineoplastic Agents; D002867:Chromones; D016166:Free Radical Scavengers; D006835:Hydrazones; D008024:Ligands; D008674:Metals, Rare Earth; D015335:Molecular Probes; D009942:Organometallic Compounds; D013481:Superoxides; D017665:Hydroxyl Radical; D004247:DNA