Intracranial tumor lysis and cerebral edema after administration of intrathecal methotrexate: a case report and discussion.
Methotrexate is a common agent used in the management of hematological malignancies, but is often associated with the development of diverse central nervous system adverse events, such as seizures. We present a case of seizures after intrathecal administration of methotrexate, during the management of diffuse large B-cell lymphoma. There was complete resolution of the CNS lesions after chemotherapy along with the interval development of diffuse cerebral edema. We hypothesize that tumor lysis is the underlying mechanism of this untoward event, resulting in the corresponding clinical presentation.
Bachegowda
Lohith S
LS
Department of Internal Medicine, Hahnemann University Hospital/Drexel University College of Medicine, Philadelphia, PA 19102, USA.
Grivas
Petros D
PD
Anand
Rachna
R
Stecker
Elissa
E
Ward
Kristine
K
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001929:Brain Edema / Q000139:chemically induced* / Q000188:drug therapy; D001932:Brain Neoplasms / Q000139:chemically induced* / Q000188:drug therapy / Q000556:secondary; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D011379:Prognosis
D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate