From ST-elevation myocardial infarction to ST elevation with no myocardial infarction--review and overview of a new horizon of computerized electrocardiographic ischemia detection using high-fidelity implantable devices.
ST-segment elevation is the clinical hallmark of ST-elevation myocardial infarction; however pathophysiologically ST elevation occurs in association with acute coronary occlusion long before any myocardial necrosis occurs, for example. with no myocardial infarction (MI). The clinical utility of these laboratory observations has previously been limited; however, with the advent of permanently implantable high-fidelity electrocardiogram monitors, such utility constitutes a new horizon for high-risk patients. Rapidly progressive changes in the endocardial electrogram, with real-time alarms, could shift the timing, and hence the paradigm of care from interruption of MI to prevention of MI.
Duke University Medical Center, Duke Clinical Research Institute, 508 Fulton Street (111A), Durham, NC 27705, USA. kruco001@mc.duke.edu
Mitchell W
MW
Krucoff
D003936:Diagnosis, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D015716:Electrocardiography, Ambulatory / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000517:prevention & control*; D019736:Prostheses and Implants; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity