Enantioselective catalysis and complexity generation from allenoates.
Lewis base catalysis of reactions with allenoates using phosphine and amine nucleophiles has emerged as a key platform for the generation of molecular complexity. Investigations in this area have established a range of suitable coupling partners for allenoates, including electron-deficient olefins, imines, and aldehydes. This tutorial review will describe these methodologies, with a special emphasis on recent work regarding asymmetric reactions using chiral Lewis base catalysts.
Cowen
Bryan J
BJ
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107, USA.
Miller
Scott J
SJ
D000466:Alkadienes / Q000737:chemistry*; D002384:Catalysis; D055601:Organic Chemistry Phenomena; D013237:Stereoisomerism
D000466:Alkadienes