A synergistic approach for neural repair: cell transplantation and induction of endogenous precursor cell activity.
Stem cell research offers enormous potential for treating many diseases of the nervous system. At present, therapeutic strategies in stem cell research segregate into two approaches: cell transplantation or endogenous cell stimulation. Realistically, future cell therapies will most likely involve a combination of these two approaches, a theme of our current research. Here, we propose that there exists a 'synergy' between exogenous (transplanted) and endogenous stem cell actions that can be utilized to achieve therapeutic ends. Elucidating mechanisms underlying this exogenous-endogenous stem cell synergism may lead to the development of optimal cell therapies for neural disorders.
Madhavan
Lalitha
L
Department of Neurology, University of Cincinnati, Cincinnati, OH 45267, USA. madhavla@ucmail.uc.edu
Collier
Timothy J
TJ
D000818:Animals; D001927:Brain Diseases / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D009474:Neurons / Q000502:physiology* / Q000637:transplantation*; D013118:Spinal Cord Diseases / Q000503:physiopathology / Q000601:surgery; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000502:physiology*