Coexistent pyoderma gangrenosum and tibialis anterior myositis as presenting manifestations of Crohn's disease: case report and review of the literature.
Crohn's disease (CD) is a well defined inflammatory bowel disease. Patients primarily present with abdominal pain and diarrhea, however, extra-intestinal manifestations due to musculoskeletal and cutaneous involvement are seen in a varying range of patients. In this communication we describe a young woman who presented with a severe inflammatory illness that consequently developed into pyoderma gangrenosum, anterior tibialis myositis and arthritis that were all antecedent to the intestinal involvement. The patient favorably responded to infliximab with concomitant azathioprine therapy.
Department of Medicine D, Meir Medical Center, Kfar-Saba, Israel. Affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Tshernichovsky 59, 44281 Kfar-Saba, Israel.
Oran
O
Goldshmid
Zamir
Z
Dovorish
Tania
T
Zehavi
Alon
A
Eisen
Yaron
Y
Bar-Dayan
Howard
H
Amital
D000328:Adult; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006801:Humans; D009220:Myositis / Q000209:etiology*; D017511:Pyoderma Gangrenosum / Q000209:etiology*