Regional cerebral blood flow in patients with alcohol-related dementia: a SPECT study.
The purpose of this study was to investigate regional cerebral blood flow (rCBF) changes using 1110 MBq of Tc-99m ECD SPECT in alcohol-related dementia (ARD) patients. Twenty-five patients with ARD and 22 healthy control subjects were included in the study. Mini-Mental Status Examination was applied to the patients and controls. The ARD patients showed drastically reduced rCBF in the frontal cortices, basal ganglia, and thalami. The results indicate that ARD is associated with hypoperfusion in both cortical and subcortical regions. These findings support previous studies suggesting the association with both cortical and subcortical neuropathology in ARD patients.
Chung
Yong-An
YA
East-West Research Institute of Translational Medicine, Incheon St. Mary's Hospital, Incheon, South Korea.
Choi
Sam-Wook
SW
Joe
Keun Ho
KH
Jeong
Jaeseung
J
Cheon
Younghoon
Y
Kim
Dai-Jin
DJ
D000368:Aged; D000425:Alcohol Amnestic Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001479:Basal Ganglia / Q000033:anatomy & histology / Q000503:physiopathology; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D018450:Disease Progression; D005625:Frontal Lobe / Q000033:anatomy & histology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013788:Thalamus / Q000033:anatomy & histology / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*