The effect of short-term aerobic training on coagulation and fibrinolytic factors in sedentary healthy postmenopausal women.
OBJECTIVE
The purpose of this study was to assess the effect of short-term aerobic training on the fibrinolytic and coagulative factors in postmenopausal women.


METHODS
Twenty volunteer sedentary healthy postmenopausal women (48-53 years), who entered the menopause naturally, were divided randomly into two groups: training (n=10) and control (n=10).


METHODS
Training consisted of 10 sessions of submaximal aerobic cycling, 35 min for each session (5 min warm-up, 25 min aerobic training with 70% HRmax, 5 min active and 15 min passive recovery), 3 times a week. Coagulation and fibrinolytic factors were assessed both before and after aerobic program in both groups.


RESULTS
Fibrinogen, von Willbrand factor (vWF-Ag) antigen, plasminogen activator inhibitor-1 activity (PAI-1:Ac) and antigen (PAI-1:Ag) showed significant reduction after 10 sessions in the training group (P<0.05). Also after training, prothrombin time (PT), partial thromboplastin time (PTT), tissue plasminogen activator activity (tPA:Ac) and antigen (tPA:Ag) increased (P<0.05).


CONCLUSIONS
It was concluded that fibrinolytic activity on postmenopausal women could be improved by a 3-week regular submaximal training program. These changes on the hemostatic factors suggest that short-term aerobic training may prevent the decline in fibrinolytic function observed in sedentary postmenopausal women.
Physical Therapy Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, PO Box 14115-331, Islamic Republic of Iran.
Tahereh
T
Jahangard
Giti
G
Torkaman
Babak
B
Ghoosheh
Mehdi
M
Hedayati
Azadeh
A
Dibaj
D000941:Antigens / Q000378:metabolism; D001642:Bicycling / Q000502:physiology; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D017698:Postmenopause / Q000378:metabolism; D011517:Prothrombin Time; D012016:Reference Values; D057185:Sedentary Behavior; D014841:von Willebrand Factor / Q000276:immunology / Q000378:metabolism
D000941:Antigens; D001779:Blood Coagulation Factors; D017395:Plasminogen Activator Inhibitor 1; C029417:Von Willebrand antigen; D014841:von Willebrand Factor; D005340:Fibrinogen