Nanowire biocompatibility in the brain--looking for a needle in a 3D stack.
We investigated the brain-tissue response to nanowire implantations in the rat striatum after 1, 6, and 12 weeks using immunohistochemistry. The nanowires could be visualized in the scar by confocal microscopy (through the scattered laser light). For the nanowire-implanted animals, there is a significant astrocyte response at week 1 compared to controls. The nanowires are phagocytized by ED1 positive microglia, and some of them are degraded and/or transported away from the brain.
Neuronano Research Center, BMC F10, Lund University, SE-221 84 Lund, Sweden. Cecilia.Eriksson_Linsmeier@med.lu.se
Cecilia
C
Eriksson Linsmeier
Christelle N
CN
Prinz
Lina M E
LM
Pettersson
Philippe
P
Caroff
Lars
L
Samuelson
Jens
J
Schouenborg
Lars
L
Montelius
Nils
N
Danielsen
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000276:immunology*; D005260:Female; D006046:Gold / Q000009:adverse effects*; D008422:Materials Testing; D043942:Nanotubes / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D006046:Gold