Pathema: a clade-specific bioinformatics resource center for pathogen research.
Pathema (http://pathema.jcvi.org) is one of the eight Bioinformatics Resource Centers (BRCs) funded by the National Institute of Allergy and Infectious Disease (NIAID) designed to serve as a core resource for the bio-defense and infectious disease research community. Pathema strives to support basic research and accelerate scientific progress for understanding, detecting, diagnosing and treating an established set of six target NIAID Category A-C pathogens: Category A priority pathogens; Bacillus anthracis and Clostridium botulinum, and Category B priority pathogens; Burkholderia mallei, Burkholderia pseudomallei, Clostridium perfringens and Entamoeba histolytica. Each target pathogen is represented in one of four distinct clade-specific Pathema web resources and underlying databases developed to target the specific data and analysis needs of each scientific community. All publicly available complete genome projects of phylogenetically related organisms are also represented, providing a comprehensive collection of organisms for comparative analyses. Pathema facilitates the scientific exploration of genomic and related data through its integration with web-based analysis tools, customized to obtain, display, and compute results relevant to ongoing pathogen research. Pathema serves the bio-defense and infectious disease research community by disseminating data resulting from pathogen genome sequencing projects and providing access to the results of inter-genomic comparisons for these organisms.
J Craig Venter Institute, Rockville, MD 20850, USA.
Lauren M
LM
Brinkac
Tanja
T
Davidsen
Erin
E
Beck
Anuradha
A
Ganapathy
Elisabet
E
Caler
Robert J
RJ
Dodson
A Scott
AS
Durkin
Derek M
DM
Harkins
Hernan
H
Lorenzi
Ramana
R
Madupu
Yinong
Y
Sebastian
Susmita
S
Shrivastava
Mathangi
M
Thiagarajan
Joshua
J
Orvis
Jaideep P
JP
Sundaram
Jonathon
J
Crabtree
Kevin
K
Galens
Yongmei
Y
Zhao
Jason M
JM
Inman
Robert
R
Montgomery
Seth
S
Schobel
Kevin
K
Galinsky
David M
DM
Tanenbaum
Adam
A
Resnick
Nikhat
N
Zafar
Owen
O
White
Granger
G
Sutton
D000595:Amino Acid Sequence; D000818:Animals; D001424:Bacterial Infections / Q000175:diagnosis / Q000382:microbiology*; D003141:Communicable Diseases / Q000382:microbiology*; D019295:Computational Biology / Q000379:methods* / Q000639:trends; D030541:Databases, Genetic; D016680:Genome, Bacterial; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods; D020407:Internet; D008969:Molecular Sequence Data; D054579:National Institute of Allergy and Infectious Diseases (U.S.); D017386:Sequence Homology, Amino Acid; D012984:Software; D014481:United States