A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands.
A multistep continuous-flow system for synthesis of receptor ligands by assembly of three variable building blocks in a single unbroken flow is described. The sequence consists of three reactions and two scavenger steps, where a Cbz-protected diamine is reacted with an isocyanate, deprotected, and reacted further with an alkylating agent.
Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.
Trine P
TP
Petersen
Andreas
A
Ritzén
Trond
T
Ulven
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017953:Isocyanates / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D010879:Piperazines; D054401:Receptors, CCR8 / Q000819:agonists
C507626:2-(2-(4-(3-phenoxybenzyl)piperazin-1-yl)ethoxy)ethanol; D000588:Amines; D017953:Isocyanates; D008024:Ligands; D010879:Piperazines; D054401:Receptors, CCR8