A lichen substance as an antiproliferative compound against HL-60 human leukemia cells: 16-O-acetyl-leucotylic acid isolated from Myelochroa aurulenta.
The lichen substance, 16-O-acetyl-leucotylic acid (1), was isolated from an acetone extract of Myelochroa aurulenta and found to exhibit antiproliferative activity against HL-60 human leukemia cells. This is the first report on its anti-leukemia activity (EC(50)=21 microM) which is greater than that of leucotylic acid (2) and the structurally related anti-tumor agent, betulinic acid (4).
Tokiwano
Tetsuo
T
Department of Biological Resource Sciences, Akita Prefectural University, Akita, Japan. tkwn@akita-pu.ac.jp
Satoh
Hikari
H
Obara
Tomohisa
T
Hirota
Hiroshi
H
Yoshizawa
Yuko
Y
Yamamoto
Yoshikazu
Y
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D008011:Lichens / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
C547204:16-O-acetyl-leucotylic acid; D000970:Antineoplastic Agents; D014315:Triterpenes