Electroconvulsive therapy increases glial cell-line derived neurotrophic factor (GDNF) serum levels in patients with drug-resistant depression.
Electroconvulsive therapy (ECT) can be effective in patients with depression resistant to pharmacologic medication. We report that serum levels of glial cell-line derived neurotrophic factor (GDNF) were increased following ECT of patients with drug-resistant depression. When patients were sub-classified into ECT responders and non-responders, serum GDNF levels were significantly increased (58%) in responsive patients following ECT. No significant increase was seen in non-responders. These results suggest that successful ECT may be associated with elevated serum GDNF levels.
Zhang
Xiaobin
X
Department of Neurology, ZhongDa Hospital of Southeast University, Nanjing, 210009, People's Republic of China. zhangxiaobim@163.com
Zhang
Zhijun
Z
Sha
Weiwei
W
Xie
Chunming
C
Xi
Guangjun
G
Zhou
Honghui
H
Zhang
Yumei
Y
D000328:Adult; D003863:Depression / Q000097:blood* / Q000628:therapy*; D004565:Electroconvulsive Therapy / Q000379:methods*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
D051100:Glial Cell Line-Derived Neurotrophic Factor