title: Prognostic factors of treatment outcomes in patients with granulocytic sarcoma.
abstract: OBJECTIVE
  To investigate the possible prognostic factors of survival outcomes in patients with granulocytic sarcoma (GS).
  
  
  METHODS
  We retrospectively investigated the prognostic factors determining survival in 24 patients with GS using Kaplan-Meier survival analysis followed by log rank tests. We evaluated gender, age, location, GS antedating leukemia, underlying disorders, treatment type and stem cell transplantation.
  
  
  RESULTS
  The 5-year survival rate for the patients with GS was 21%. The patients undergoing chemotherapy had a significantly longer survival time compared to those who did not (p = 0.0009). We found no difference in the 5-year survival rate among the patients undergoing chemotherapy combined with radiation or surgery. Patients with chronic myelogenous leukemia and myelodysplastic disorders had worse survival rates (p = 0.0028).
  
  
  CONCLUSIONS
  Early diagnosis with biopsy and early chemotherapy can improve survival outcome. Local radiation or surgery can improve symptoms but does not influence survival outcomes.
authors.affiliation: Department of Orthopedics, National Taiwan University and Hospital, Taipei, Taiwan, ROC.
authors.forename: Tsung-Yu
authors.initials: TY
authors.lastname: Lan
authors.forename: Dong-Tsamn
authors.initials: DT
authors.lastname: Lin
authors.forename: Hwei-Fang
authors.initials: HF
authors.lastname: Tien
authors.forename: Rong-Sen
authors.initials: RS
authors.lastname: Yang
authors.forename: Chih-Yu
authors.initials: CY
authors.lastname: Chen
authors.forename: Karl
authors.initials: K
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000401:mortality / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D023981:Sarcoma, Myeloid / Q000175:diagnosis / Q000235:genetics / Q000401:mortality / Q000628:therapy*; D014178:Translocation, Genetic; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents