Role of melanin in the pathogenesis of cutaneous sporotrichosis.
In this study, we evaluate the clinical, histopathological and ultra structural aspects of the infection by field strain (MEL(+)) and mutated strain (MEL(-)) of Sporothrix schenckii. The development of sporotrichosis at the inoculation sites was similar for both groups of animals after the second week of the experimental period. Statistical differences appeared only at weeks 3 and 5. The pigmented isolate had greater tissue invasive capacity, promoting the formation of multifocal granulomas, whereas the albino isolate induced an enhanced inflammatory response, restraining the agent to the core of the granulomas.
Madrid
Isabel Martins
IM
Departamento de Veterinária Preventiva, Faculdade de Veterinária, Universidade Federal de Pelotas, Campus Universitário s/n, 96010-900, Pelotas, Rio Grande do Sul, Brazil. imadrid_rs@yahoo.com.br
Xavier
Melissa O
MO
Mattei
Antonella S
AS
Fernandes
Cristina G
CG
Guim
Thomaz N
TN
Santin
Rosema
R
Schuch
Luiz Filipe D
LF
Nobre
Márcia de Oliveira
Mde O
Araújo Meireles
Mário Carlos
MC
D000818:Animals; D004195:Disease Models, Animal; D005528:Foot / Q000382:microbiology / Q000473:pathology; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008297:Male; D008543:Melanins / Q000235:genetics / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000382:microbiology / Q000473:pathology; D013154:Spleen / Q000382:microbiology / Q000473:pathology; D013175:Sporothrix / Q000302:isolation & purification / Q000378:metabolism / Q000472:pathogenicity*; D013174:Sporotrichosis / Q000382:microbiology* / Q000473:pathology; D037521:Virulence Factors / Q000502:physiology*
D008543:Melanins; D037521:Virulence Factors