Kinetics of nanoparticle targeting by dissipative particle dynamics simulations.
Dissipative particle dynamics simulations are applied to study nanoparticle targeting to a cell surface containing a high concentration of receptors. We found that the normalized number of bound ligands follows an exponential growth function 1 - exp(-t/tau), with the lifetime tau increasing as a function of the binding strength. With increasing binding energy, the shape of the adsorbed nanoparticle becomes ellipsoidal due to a large number of stably bound ligands, most of which are positioned on the nanoparticle periphery. For a low degree of functionalization of homogeneously distributed ligands, the kinetics of nanoparticle attachment slows down due to interference by nonfunctional chains, the overall number of bound ligands at equilibrium decreases, although the stability of ligand attachment increases. Janus-like nanoparticles with functionalized chains positioned on one side of the nanoparticle exhibit more rapid binding to the cell surface with a large equilibrium number of stably bound ligands.
Djohari
Hadrian
H
Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Dormidontova
Elena E
EE
D003198:Computer Simulation; D007700:Kinetics; D008024:Ligands; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011485:Protein Binding / Q000502:physiology; D017433:Protein Structure, Secondary / Q000502:physiology; D021381:Protein Transport / Q000502:physiology; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism; D013499:Surface Properties; D013997:Time Factors
D008024:Ligands; D011956:Receptors, Cell Surface