Biosynthesis of resorcylic acid lactone (5S)-5-hydroxylasiodiplodin in Lasiodiplodia theobromae.
An administration study of (2)H-labeled precursors showed that the 9-hydroxydecanoyl unit, the acyl intermediate of lasiodiplodin (1), was also the intermediate of (5S)-5-hydroxylasiodiplodin (2) in Lasiodiplodia theobromae. The incorporation of [O-methyl-(2)H(3)]-lasiodiplodin (6) into 2 indicated that hydroxylation at C-5 occurred after cyclization.
Kashima
Takasumi
T
Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Sapporo, Japan.
Takahashi
Kosaku
K
Matsuura
Hideyuki
H
Nabeta
Kensuke
K
D001203:Ascomycota / Q000201:enzymology / Q000378:metabolism*; D007553:Isotope Labeling; D007783:Lactones / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015025:Zearalenone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
C547203:5-hydroxylasiodiplodin; D007783:Lactones; D015025:Zearalenone