Leptin levels in thyroid cancer.
BACKGROUND
Leptin has physiological roles in multiple systems, and has possible effects on several carcinogenesis steps. The aim of this study was to investigate the leptin levels in thyroid papillary carcinoma (TPC) patients.


METHODS
Forty-three female TPC patients and 30 healthy female control subjects were recruited for the study. TPC was diagnosed by fine needle aspiration biopsy. TPC patients had a bilateral total thyroidectomy operation and their leptin levels were measured before and 20 days after the operation.


RESULTS
Serum leptin levels of TPC patients were higher than in control group subjects (21.15 +/- 14.12 ng/mL vs. 9.89 +/- 0.21 ng/mL, p < 0.05). The leptin levels decreased after total thyroidectomy (13.92 +/- 10.55 ng/mL) compared to prethyroidectomy levels (22.94 +/- 14.67 ng/mL) in 34 patients who came to the follow-up visit (p < 0.05). However, the decreased post-thyroidectomy levels of leptin were still statistically significantly higher than the control group levels. Multivariate regression analysis showed that the leptin levels in TPC patients were not related to age, menopausal status or pathologic occult status but were directly related to the cancer group.


CONCLUSIONS
Leptin levels were elevated in thyroid cancer, decreased after total thyroidectomy, and might be associated with thyroid papillary carcinogenesis.
Akinci
Melih
M
Department of General Surgery, Ankara Diskapi Education and Research Hospital, Ankara, Turkey. melihakinci@yahoo.com
Kosova
Funda
F
Cetin
Bahadir
B
Aslan
Sabahattin
S
Ari
Zeki
Z
Cetin
Abdullah
A
D000328:Adult; D002291:Carcinoma, Papillary / Q000097:blood* / Q000601:surgery; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D013964:Thyroid Neoplasms / Q000097:blood* / Q000601:surgery; D013965:Thyroidectomy
D020738:Leptin