title: Effect of furosemide and furosemide-carbazochrome combination on exercise-induced pulmonary hemorrhage in Standardbred racehorses.
abstract: The objective was to quantify the effect of furosemide and carbazochrome on exercise-induced pulmonary hemorrhage (EIPH) in Standardbred horses using red blood cell count and hemoglobin concentration in bronchoalveolar lavage (BAL) fluid. Six healthy Standardbred horses with prior evidence of EIPH performed a standardized treadmill test 4 h after administration of placebo, furosemide, or furosemide-carbazochrome combination. Red blood cell (RBC) counts and hemoglobin concentrations were determined on the BAL fluid. The RBC count in BAL ranges were (2903-26,025 cells/microL), (45-24,060 cells/microL), and (905-3045 cells/microL) for placebo, furosemide, and furosemide-carbazochrome, respectively. Hemoglobin concentration ranges were (0.03-0.59 mg/mL), (0.01-0.55 mg/mL), and (0.007-0.16 mg/mL) for placebo, furosemide, and furosemide-carbazochrome groups, respectively. No significant differences were detected among treatments. However, there was great variability among horses, suggesting that a larger sample size or better selection of horses was needed.
authors.affiliation: Animal Science, Purdue University, West Lafayette, Indiana 47906, USA.
authors.forename: Cecilia I
authors.initials: CI
authors.lastname: Perez-Moreno
authors.forename: Laurent L
authors.initials: LL
authors.lastname: Couëtil
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Pratt
authors.forename: Hugo G
authors.initials: HG
authors.lastname: Ochoa-Acuña
authors.forename: Rose E
authors.initials: RE
authors.lastname: Raskin
authors.forename: Mark A
authors.initials: MA
authors.lastname: Russell
mesh_terms: D000323:Adrenochrome / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D018592:Cross-Over Studies; D004232:Diuretics / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005080:Exercise Test / Q000662:veterinary; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D006470:Hemorrhage / Q000188:drug therapy / Q000662:veterinary*; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D008171:Lung Diseases / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D010805:Physical Conditioning, Animal / Q000009:adverse effects*; D011897:Random Allocation; D016896:Treatment Outcome
chemical_list: D004232:Diuretics; D000323:Adrenochrome; D005665:Furosemide; C073338:carbazochrome