title: Anti-inflammatory effect of the polysaccharides of golden needle mushroom in burned rats.
abstract: The present study was to investigate chemical components of polysaccharides isolated from Golden needle (GNP) mushroom using high performance liquid chromatography (HPLC) and nuclear magnetic resonance spectroscopy (NMR). Then, anti-inflammatory effect of the polysaccharides was also evaluated. Results indicated that GNP was composed of the three monosaccharides (glucose, mannose and xylose) with a molar ratio of 3.5:0.8:1.4. GNP could significantly decreased CD4+ CD8+, ICAM-1, and MPO in serum and colon of normal and burned rats. It could be concluded that GNP possessed strong anti-inflammatory activity in burned rats.
authors.affiliation: Department of Plastic and Burns Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, PR China.
authors.forename: Dong-mei
authors.initials: DM
authors.lastname: Wu
authors.forename: Wei-qiang
authors.initials: WQ
authors.lastname: Duan
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Cen
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002056:Burns / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology; D015704:CD4 Antigens / Q000097:blood; D016827:CD8 Antigens / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D003106:Colon / Q000378:metabolism; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008970:Molecular Weight; D009195:Peroxidase / Q000097:blood; D011134:Polysaccharides / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D015704:CD4 Antigens; D016827:CD8 Antigens; D011134:Polysaccharides; D018799:Intercellular Adhesion Molecule-1; D016753:Interleukin-10; D009195:Peroxidase