[Prevention, early diagnosis and treatment of chemoextravasation. Practical management in the uro-oncological practice].
Extravasation of chemotherapeutic agents is a rare (1-6%) but potentially severe iatrogenic complication of systemic therapy. Depending on the cytotoxic agent, tissue damage and necrosis may occur, followed by a delay in administration of chemotherapy, prolonged hospitalization, impaired function, and the need for tissue excision. Therefore, optimal placement of the intravenous catheter is absolutely necessary to reduce the risk of extravasation. The aim of this report is to give urologists a practical and useful guide on how to prevent, diagnose, and treat this complication.
Rinnab
L
L
Klinik für Urologie und Kinderurologie, Universität Ulm, Prittwitzstrasse, Ulm, Deutschland. ludwig.rinnab@uniklinik-ulm.de
Ringhoffer
M
M
Mayer-Steinacker
R
R
Hautmann
R E
RE
Simon
J
J
D000931:Antidotes / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D003875:Drug Eruptions / Q000175:diagnosis* / Q000628:therapy; D004630:Emergencies; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000517:prevention & control*; D006801:Humans; D007049:Iatrogenic Disease; D007262:Infusions, Intravenous / Q000009:adverse effects; D009336:Necrosis; D012307:Risk Factors; D012867:Skin / Q000187:drug effects; D014565:Urogenital Neoplasms / Q000188:drug therapy*
D000931:Antidotes; D000970:Antineoplastic Agents