Antitumor activity of diethynylfluorene derivatives of gold(I).
A list of diethynylfluorenes and their gold(I) derivatives have been studied for their antitumor activity as a function of their structure-activity relationships. End-capping the fluoren-9-one unit with gold(I) moieties could significantly strengthen the cytotoxic activity in vitro on three human cancer cell lines with induction of reactive oxygen species generation on Hep3B hepatocellular carcinoma cells and exhibit attractive antitumor activity from in vivo nude mice Hep3B xenograft model with limited adverse effects on vital organs including liver and kidney.
Chui
Chung-Hin
CH
Institute of Textiles and Clothing, Hong Kong Polytechnic University, Hung Hom, Hong Kong, People's Republic of China.
Wong
Raymond Siu-Ming
RS
Gambari
Roberto
R
Cheng
Gregory Yin-Ming
GY
Yuen
Marcus Chun-Wah
MC
Chan
Kit-Wah
KW
Tong
See-Wai
SW
Lau
Fung-Yi
FY
Lai
Paul Bo-San
PB
Lam
Kim-Hung
KH
Ho
Cheuk-Lam
CL
Kan
Chi-Wai
CW
Leung
Kelvin Sze-Yin
KS
Wong
Wai-Yeung
WY
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006046:Gold / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D005449:Fluorenes; D009942:Organometallic Compounds; D006046:Gold