title: Electroconvulsive therapy increases glial cell-line derived neurotrophic factor (GDNF) serum levels in patients with drug-resistant depression.
abstract: Electroconvulsive therapy (ECT) can be effective in patients with depression resistant to pharmacologic medication. We report that serum levels of glial cell-line derived neurotrophic factor (GDNF) were increased following ECT of patients with drug-resistant depression. When patients were sub-classified into ECT responders and non-responders, serum GDNF levels were significantly increased (58%) in responsive patients following ECT. No significant increase was seen in non-responders. These results suggest that successful ECT may be associated with elevated serum GDNF levels.
authors.affiliation: Department of Neurology, ZhongDa Hospital of Southeast University, Nanjing, 210009, People's Republic of China. zhangxiaobim@163.com
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Zhang
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Weiwei
authors.initials: W
authors.lastname: Sha
authors.forename: Chunming
authors.initials: C
authors.lastname: Xie
authors.forename: Guangjun
authors.initials: G
authors.lastname: Xi
authors.forename: Honghui
authors.initials: H
authors.lastname: Zhou
authors.forename: Yumei
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D003863:Depression / Q000097:blood* / Q000628:therapy*; D004565:Electroconvulsive Therapy / Q000379:methods*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D051100:Glial Cell Line-Derived Neurotrophic Factor