title: Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging.
abstract: BACKGROUND
  Our objectives were to compare the effects of subcortical ischemic vascular dementia (SIVD) and Alzheimer's disease (AD) on cerebral blood flow (CBF), and then to analyze the relationship between CBF and subcortical vascular disease, measured as volume of white-matter lesions (WMLs).
  
  
  METHODS
  Eight mildly demented patients with SIVD (mean +/- SD; aged 77 +/- 8 years; Mini-Mental State Examination score 26 +/- 3 years) and 14 patients with AD were compared with 18 cognitively normal elderly subjects. All subjects had CBF measured using arterial spin-labeling magnetic resonance imaging, and brain volumes were assessed using structural magnetic resonance imaging.
  
  
  RESULTS
  AD and SIVD showed marked CBF reductions in the frontal (P = 0.001) and parietal (P = 0.001) cortices. In SIVD, increased subcortical WMLs were associated with reduced CBF in the frontal cortex (P = 0.04), in addition to cortical atrophy (frontal, P = 0.05; parietal, P = 0.03).
  
  
  CONCLUSIONS
  Subcortical vascular disease is associated with reduced CBF in the cortex, irrespective of brain atrophy.
authors.affiliation: Department of Veterans Affairs Medical Center, University of California at San Francisco, USA. norbert.schuff@ucsf.edu
authors.forename: Norbert
authors.initials: N
authors.lastname: Schuff
authors.forename: Shinji
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Joseph
authors.initials: J
authors.lastname: Kmiecik
authors.forename: Colin
authors.initials: C
authors.lastname: Studholme
authors.forename: Antao
authors.initials: A
authors.lastname: Du
authors.forename: Frank
authors.initials: F
authors.lastname: Ezekiel
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Miller
authors.forename: Joel H
authors.initials: JH
authors.lastname: Kramer
authors.forename: William J
authors.initials: WJ
authors.lastname: Jagust
authors.forename: Helen C
authors.initials: HC
authors.lastname: Chui
authors.forename: Michael W
authors.initials: MW
authors.lastname: Weiner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology*; D001284:Atrophy / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D002536:Cerebral Arteries / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D015140:Dementia, Vascular / Q000473:pathology / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013113:Spin Labels
chemical_list: D013113:Spin Labels