title: No major clinical impact of Val66Met BDNF gene polymorphism on temporal lobe epilepsy.
abstract: OBJECTIVE
  To report the frequencies of Val66Met polymorphism in patients with temporal lobe epilepsy (TLE) compared to normal controls. We also investigated whether Val66Met promoted differences in major clinical variables of TLE.
  
  
  METHODS
  A case-control study comparing the frequencies of Val66Met polymorphism in 101 Caucasian TLE patients and in 104 Caucasian normal matching controls. In the second step, we evaluated the patient group in terms of the major clinical and electrographic variables related to the epileptogenic process.
  
  
  RESULTS
  The frequency of Val66Met polymorphism did not differ between epileptic patients and normal controls. Moreover, the Val66Met polymorphisms did not influence age of epilepsy onset, duration of epilepsy, control of seizures, or extension of the irritative zone. Also, the groups did not differ in terms of family history of epilepsy and presence of aura.
  
  
  CONCLUSIONS
  In spite of abundant evidence that Val66Met BDNF polymorphism has an impact on several different neurological or psychiatric disorders, we conclude that a major clinical impact of Val66Met polymorphism as a disease modifier in temporal lobe epilepsy is probably unlikely.
authors.affiliation: Division of Neurology, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil. jbragatti@hcpa.ufrgs.br
authors.forename: José Augusto
authors.initials: JA
authors.lastname: Bragatti
authors.forename: Laila Cigana
authors.initials: LC
authors.lastname: Schenkel
authors.forename: Carolina Machado
authors.initials: CM
authors.lastname: Torres
authors.forename: Gisele Gus
authors.initials: GG
authors.lastname: Manfro
authors.forename: Carolina
authors.initials: C
authors.lastname: Blaya
authors.forename: Ana Claudia de
authors.initials: AC
authors.lastname: Souza
authors.forename: Diogo Onofre Gomes de
authors.initials: DO
authors.lastname: Souza
authors.forename: Maria Luiza
authors.initials: ML
authors.lastname: Saraiva-Pereira
authors.forename: Laura Bannach
authors.initials: LB
authors.lastname: Jardim
authors.forename: Sandra
authors.initials: S
authors.lastname: Leistner-Segal
authors.forename: Marino Muxfeldt
authors.initials: MM
authors.lastname: Bianchin
mesh_terms: D000328:Adult; D017668:Age of Onset; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D019208:Brain-Derived Neurotrophic Factor