title: Glioblastoma multiforme in a patient with chronic granulomatous disease treated with subtotal resection, radiation, and thalidomide: case report of a long-term survivor.
abstract: We report on a child with chronic granulomatous disease who at the age of 13 years was diagnosed with glioblastoma multiforme of the left thalamus. Therapy included subtotal resection, radiation to the tumor bed (60 Gy), and concomitant chemotherapy with daily thalidomide (250 mg/m2), both during radiation and for 5 years thereafter. Currently, she is 9 years from diagnosis and has no evidence of disease. Therapy with thalidomide did not increase her infection complications and provided excellent quality of life. This is the first report of glioblastoma multiforme in a patient with chronic granulomatous disease treated with surgery, radiation, and thalidomide who is a long-term survivor.
authors.affiliation: Division of Hematology-Oncology and Stem Cell Transplantation, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA.
authors.forename: Dolly G
authors.initials: DG
authors.lastname: Aguilera
authors.forename: Tadanori
authors.initials: T
authors.lastname: Tomita
authors.forename: Veena
authors.initials: V
authors.lastname: Rajaram
authors.forename: Jason
authors.initials: J
authors.lastname: Fangusaro
authors.forename: Ben Z
authors.initials: BZ
authors.lastname: Katz
authors.forename: Stanford
authors.initials: S
authors.lastname: Shulman
authors.forename: Stewart
authors.initials: S
authors.lastname: Goldman
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D003399:Craniotomy; D003937:Diagnosis, Differential; D005260:Female; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D006105:Granulomatous Disease, Chronic / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D006801:Humans; D011788:Quality of Life; D011829:Radiation Dosage; D017741:Survivors; D013792:Thalidomide / Q000627:therapeutic use*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D013792:Thalidomide