Bioproduction of resveratrol and stilbene derivatives by plant cells and microorganisms.
Trans-resveratrol is a phenolic plant compound that has been recognized for its benefits on human health. Currently, increasing demand for trans-resveratrol for nutraceutical, cosmetic, and putatively pharmaceutic uses makes its production from sustainable sourcing a necessity. In this context, the use of biotechnology through recombinant microorganisms and plant cell suspensions is particularly promising because it represents a reliable alternative method of trans-resveratrol production under controlled conditions. Tailoring yeast or bacteria with genes that encode enzymes of the trans-resveratrol pathway and further elicitation of plant-cell metabolism might represent powerful strategies for increased trans-resveratrol bioproduction. This review aims at describing and comparing these different available methods, with a focus on their respective advantages, limits and perspectives as a basis for scale-up in large culture volumes.
Donnez
David
D
Laboratoire de Stress, Défenses et Reproduction des Plantes, Unité de Recherche Vigne et Vins de Champagne-Stress et Environnement, EA 2069, UFR Sciences Exactes et Naturelles, Université de Reims Champagne-Ardenne, BP 1039, 51687 Reims Cedex 02, France.
Jeandet
Philippe
P
Clément
Christophe
C
Courot
Eric
E
D001419:Bacteria / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods*; D018929:Cell Culture Techniques / Q000379:methods; D006801:Humans; D030781:Organisms, Genetically Modified / Q000378:metabolism; D010944:Plants / Q000378:metabolism*; D000077185:Resveratrol; D013267:Stilbenes / Q000378:metabolism*; D015003:Yeasts / Q000378:metabolism*
D013267:Stilbenes; D000077185:Resveratrol