Multiple routes of protein transport from endosomes to the trans Golgi network.
Proteins use multiple routes for transport from endosomes to the Golgi complex. Shiga and cholera toxins and TGN38/46 are routed from early and recycling endosomes, while mannose 6-phosphate receptors are routed from late endosomes. The identification of distinct molecular requirements for each of these pathways makes it clear that mammalian cells have evolved more complex targeting mechanisms and routes than previously anticipated.
Pfeffer
Suzanne R
SR
Department of Biochemistry, 279 Campus Drive B400, Stanford University School of Medicine, Stanford, CA 94305-5307, USA. pfeffer@stanford.edu
D000818:Animals; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D021381:Protein Transport; D017527:Receptor, IGF Type 2 / Q000737:chemistry / Q000378:metabolism; D021601:trans-Golgi Network / Q000378:metabolism*
D017527:Receptor, IGF Type 2