title: Development of tip-enhanced optical spectroscopy for biological applications: a review.
abstract: Tip-enhanced optical spectroscopy is an approach that holds a good deal of promise for the nanoscale characterisation of matter. Tip-enhanced Raman spectroscopy (TERS) has been demonstrated on a variety of samples: inorganic, organic and biological. Imaging using TERS has been shown for carbon nanotubes due to their high scattering efficiency. There are a number of compelling motivations to consider alternative approaches for biological samples; most importantly, the potential for heat damage of biomolecules and long acquisition times. These issues may be addressed through the development of tip-enhanced coherent anti-Stokes Raman scattering microscopy.
authors.affiliation: Centre for Biomedical Engineering, The School of Engineering, The University of Edinburgh, Edinburgh, EH9 3JL, UK. Alistair.Elfick@ed.ac.uk
authors.forename: Alistair P D
authors.initials: AP
authors.lastname: Elfick
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Downes
authors.forename: Rabah
authors.initials: R
authors.lastname: Mouras
mesh_terms: D001709:Biotechnology / Q000639:trends; D005898:Glass / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013499:Surface Properties
chemical_list: D037742:Nanotubes, Carbon; D012235:Rhodamines