Comparison between stereo angiographic findings and histopathologic findings in endotoxin-induced uveitis.
OBJECTIVE
To carry out a three-dimensional analysis of uveitis using stereo angiography.


METHODS
Endotoxin-induced uveitis was induced by injecting lipopolysaccharide into the rat footpad, and the findings of stereo angiography with a scanning laser ophthalmoscope were compared to histopathologic results.


RESULTS
On day 2, multiple hyperfluorescent spots were observed by indocyanine green stereo angiography, which appeared to be in the superficial layer of the retina. Histopathologic findings showed infiltration of leukocytes into the corresponding area, which was the retinal nerve fiber layer.


CONCLUSIONS
Stereo angiography was considered useful for three-dimensional analysis of uveitis lesions in the retina and choroid.
Miyashita
Hiroaki
H
Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan. hiro miyashita@hotmail.com
Tagawa
Shigeki
S
Takeda
Hisashi
H
Higashide
Tomomi
T
Sugiyama
Kazuhisa
K
D000818:Animals; D002196:Capillaries / Q000473:pathology; D004396:Coloring Agents; D004195:Disease Models, Animal; D004731:Endotoxins; D005451:Fluorescein Angiography; D021621:Imaging, Three-Dimensional; D007208:Indocyanine Green; D007958:Leukocyte Count; D008070:Lipopolysaccharides; D008297:Male; D009887:Ophthalmoscopy; D051381:Rats; D011914:Rats, Inbred BN; D012171:Retinal Vessels / Q000276:immunology / Q000473:pathology*; D014605:Uveitis / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*
D004396:Coloring Agents; D004731:Endotoxins; D008070:Lipopolysaccharides; C044101:endotoxin, Escherichia coli; D007208:Indocyanine Green