title: Abdominal aortitis after use of granulocyte colony-stimulating factor.
abstract: Granulocyte colony-stimulating factor (G-CSF) is a recombinant human glycoprotein that promotes proliferation and differentiation of granulocytic-committed progenitors. It is commonly used to treat neutropenia and is generally well tolerated. Occurrences of rare but serious adverse events in association with the use of G-CSF have been described. We report the case of a 54-year-old male with squamous cell carcinoma of the lung who developed abdominal aortitis following the use of G-CSF. Other possible aetiological conditions were excluded based on laboratory and radiological evaluations. To our knowledge, this represents the second case report demonstrating an association between aortitis and the use of G-CSF.
authors.affiliation: Department of Oncology, Montefiore Medical Center North Division, New York Medical College, Bronx, NY 10466, USA.
authors.forename: Giridhar U
authors.initials: GU
authors.lastname: Adiga
authors.forename: Dahlia
authors.initials: D
authors.lastname: Elkadi
authors.forename: Sandeep K
authors.initials: SK
authors.lastname: Malik
authors.forename: Jill D
authors.initials: JD
authors.lastname: Fitzpatrick
authors.forename: Stefan
authors.initials: S
authors.lastname: Madajewicz
mesh_terms: D001025:Aortitis / Q000139:chemically induced*; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy / Q000209:etiology
chemical_list: D016179:Granulocyte Colony-Stimulating Factor