title: Value of right ventricular-left ventricular interlead electrical delay to predict reverse remodelling in cardiac resynchronization therapy: the INTER-V pilot study.
abstract: OBJECTIVE
  Few studies have systematically evaluated the value of intra-procedural parameters in predicting response to cardiac resynchronization therapy (CRT). We investigated whether intracardiac (electrogram) measurements of electrical delays between the positioned right ventricular (RV) and left ventricular (LV) leads at implantation could predict the mid-term CRT response.
  
  
  RESULTS
  Fifty-two patients underwent CRT implantation according to standard techniques and clinical indications. The RV-LV interlead electrical delay measured during spontaneous rhythm and the difference between the pacing-induced (Deltap) RV-LV interlead electrical delays measured during RV and LV pacing were defined intraoperatively using the electrical depolarizations registered at the ventricular leads on the device programmer. At 6 months, a reduction of LV end-systolic volume > or = 15% was used to define CRT responders. Responders (62%), when compared with non-responders, showed a higher proportion of ischaemic aetiology (P = 0.007) and a lower value of DeltapRV-LV interlead electrical delay (22.1 +/- 18.4 vs. 46.3 +/- 15.0 ms, P = 0.0001). At multivariate analysis, the DeltapRV-LV interlead electrical delay was the only independent predictor of response to CRT (P = 0.001). For such a parameter, the receiving operating characteristic curve analysis identified a cut-off value of 42 ms corresponding with the highest accuracy: sensitivity 90.6%; specificity 70%; positive and negative predictive value 83% and 82%, respectively. Conversely, no difference was ascertained between responders and non-responders when RV-LV interlead electrical delay was measured during spontaneous rhythm (76.1 +/- 28.5 vs. 89.6 +/- 21.2, P = 0.078).
  
  
  CONCLUSIONS
  Intraprocedural measuring of paced RV-LV interlead electrical delay obtained during RV and LV pacing predicts mid-term CRT response.
authors.affiliation: Department of Cardiology, Bentivoglio Hospital, Azienda USL di Bologna, Via Marconi, 35-40010 Bentivoglio, Bologna, Italy. biagio.sassone@ausl.bologna.it
authors.forename: Biagio
authors.initials: B
authors.lastname: Sassone
authors.forename: Luca
authors.initials: L
authors.lastname: Gabrieli
authors.forename: Saverio
authors.initials: S
authors.lastname: Saccà
authors.forename: Giulio
authors.initials: G
authors.lastname: Boggian
authors.forename: Antonio
authors.initials: A
authors.lastname: Fusco
authors.forename: Claudio
authors.initials: C
authors.lastname: Pratola
authors.forename: Maria Letizia
authors.initials: ML
authors.lastname: Bacchi-Reggiani
authors.forename: Luigi
authors.initials: L
authors.lastname: Padeletti
authors.forename: Serge S
authors.initials: SS
authors.lastname: Barold
mesh_terms: D000368:Aged; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D005260:Female; D006333:Heart Failure / Q000175:diagnosis* / Q000517:prevention & control*; D006801:Humans; D008297:Male; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control*; D018497:Ventricular Dysfunction, Right / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control*