Rare merosesquiterpenoids from basidiomycete Craterellus odoratus and their inhibition of 11beta-hydroxysteroid dehydrogenases.
Rare merosesquiterpenoids, craterellins A-C (1-3), were isolated from cultures of basidiomycete Craterellus odoratus together with the previously known massarinolin C (4). Structures of 1-3 were elucidated on the basis of extensive spectroscopic analysis. Compounds 1-3 possess a rare, epoxymethylenecyclohexanetriol-bicyclofarnesane sesquiterpene hybrid skeleton. Compounds 1-4 were evaluated for their inhibitory activities against two isozymes of 11beta-hydroxysteroid dehydrogenases (11beta-HSD1 and 11beta-HSD2).
Zhang
Ling
L
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Shen
Yu
Y
Wang
Fei
F
Leng
Ying
Y
Liu
Ji-Kai
JK
D042842:11-beta-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors*; D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D002460:Cell Line; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007527:Isoenzymes; D051379:Mice; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D007527:Isoenzymes; D012717:Sesquiterpenes; C551019:craterellin A; C551021:craterellin B; C551020:craterellin C; C551022:massarinolin C; D042842:11-beta-Hydroxysteroid Dehydrogenases