title: Modeling and simulation of the immune system as a self-regulating network.
abstract: Numerous aspects of the immune system operate on the basis of complex regulatory networks that are amenable to mathematical and computational modeling. Several modeling frameworks have recently been applied to simulating the immune system, including systems of ordinary differential equations, delay differential equations, partial differential equations, agent-based models, and stochastic differential equations. In this chapter, we summarize several recent examples of work that has been done in immune modeling and discuss two specific examples of models based on DDEs that can be used to understand the dynamics of T cell regulation.
authors.affiliation: Department of Mathematics, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Peter S
authors.initials: PS
authors.lastname: Kim
authors.affiliation: Department of Mathematics and Center for Scientific Computation and Mathematical Modeling (CSCAMM), University of Maryland, College Park, Maryland, USA.
authors.forename: Doron
authors.initials: D
authors.lastname: Levy
authors.affiliation: Division of Hematology, Department of Medicine, Stanford University, Stanford, California, USA.
authors.forename: Peter P
authors.initials: PP
authors.lastname: Lee
mesh_terms: D000465:Algorithms; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003198:Computer Simulation; D025461:Feedback, Physiological / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000502:physiology*; D008954:Models, Biological; D008962:Models, Theoretical; D017634:Self Tolerance / Q000276:immunology; D015398:Signal Transduction / Q000502:physiology; D013269:Stochastic Processes; D013601:T-Lymphocytes / Q000276:immunology