title: Comparison of critical drug-drug interaction listings: the Department of Veterans Affairs medical system and standard reference compendia.
abstract: The objective of this study was to evaluate the agreement among the US Department of Veterans Affairs (VA) listing of "critical" drug-drug interactions (DDIs) and two standard drug-interaction compendia. A list of critical DDIs, as defined by the VA, was compared with two standard commercially available compendia (Micromedex DRUG-REAX and Drug Interactions: Analysis and Management (DIAM)) in order to determine the level of agreement among the systems. Of 982 DDIs classified as critical by the VA, only 136 DDIs (13.7%) were considered critical in all three systems. Our conclusion was that, overall, there is poor agreement among the compendia and the VA system.
authors.affiliation: Department of Pharmacy Practice and Science, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
authors.forename: E L
authors.initials: EL
authors.lastname: Olvey
authors.forename: S
authors.initials: S
authors.lastname: Clauschee
authors.forename: D C
authors.initials: DC
authors.lastname: Malone
mesh_terms: D004346:Drug Information Services / Q000592:standards*; D004347:Drug Interactions / Q000502:physiology; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010602:Pharmacopoeias as Topic / Q000592:standards*; D014481:United States; D014493:United States Department of Veterans Affairs / Q000592:standards*
chemical_list: D004364:Pharmaceutical Preparations