Rearrangements of NTRK1 gene in papillary thyroid carcinoma.
TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3' terminal sequences of the NTRK1/NGF receptor gene with 5' terminal sequences of various activating genes, such as TPM3, TPR and TFG. TRK oncoproteins display constitutive tyrosine-kinase activity, leading to in vitro and in vivo transformation. In this review studies performed during the last 20 years will be summarized. The following topics will be illustrated: (a) frequency of TRK oncogenes and correlation with radiation and tumor histopathological features; (b) molecular mechanisms underlying NTRK1 oncogenic rearrangements; (c) molecular and biochemical characterization of TRK oncoproteins, and their mechanism of action; (d) role of activating sequences in the activation of TRK oncoproteins.
Greco
A
A
Department of Experimental Oncology and Laboratory, Operative Unit 3 Molecular Mechanisms of Cancer Growth and Progression, Fondazione IRCCS - Istituto Nazionale dei Tumori, Via G. Venezian 1, 20133 Milan, Italy. angela.greco@istitutotumori.mi.it
Miranda
C
C
Pierotti
M A
MA
D000818:Animals; D001483:Base Sequence; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000473:pathology; D015321:Gene Rearrangement / Q000235:genetics*; D052138:Genes, Neoplasm / Q000235:genetics; D006801:Humans; D020917:Receptor, trkA / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology
D020917:Receptor, trkA