title: Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli.
abstract: Neisseria meningitidis can produce a TolC-like protein needed for secretion of FrpC but not efflux of antimicrobials. We now report that expression of the meningococcal tolC gene in a TolC-deficient strain of Escherichia coli can restore properties of alpha-hemolysis and antimicrobial resistance known to involve efflux pumps.
authors.affiliation: Department of Microbiology, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Nazia
authors.initials: N
authors.lastname: Kamal
authors.forename: William M
authors.initials: WM
authors.lastname: Shafer
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D004926:Escherichia coli / Q000235:genetics* / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000096:biosynthesis / Q000235:genetics; D005816:Genetic Complementation Test; D006460:Hemolysin Proteins / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D009345:Neisseria meningitidis / Q000235:genetics / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D006460:Hemolysin Proteins; C036507:Hlya protein, E coli