[Type III secretion system of Vibrio parahaemolyticus--a review].
Vibrio parahaemolyticus is a halophilic gram-negative bacterium that causes food borne acute gastroenteritis in human being or certain diseases in aquatic species. In addition to thermostable direct hemolysin (tdh) and tdh-related hemolysin (trh), two sets of type III secretion systems (T3SS) were recently found to be associated closely with virulence. T3SS1 located on chromosome 1 is involved in cytotoxicity to host cells and orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and eventual cell lysis. T3SS2 in chromosome 2 is enterotoxic. In this we address the composition of the two T3SS, their functions and regulation in Vibrio parahaemolyticus.
Yu
Ying
Y
Zhejiang Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou 310029, China. yuyingye@zju.edu.cn
Wu
Beibei
B
Fang
Weihuan
W
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D014735:Vibrio Infections / Q000382:microbiology*; D014736:Vibrio parahaemolyticus / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism*
D001426:Bacterial Proteins; D037521:Virulence Factors