A kinetic overview of the receptors involved in 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 signaling: a systems biology approach.
The vitamin D endocrine system modulates an arsenal of important biological functions in more than 30 different tissues in short- and long-term perspectives. Two membrane receptors and one nuclear receptor are suggested to be involved in the vitamin D signaling system, but the function and physiological relevance of the receptors are debated. The complexity of the vitamin D endocrine system makes it necessary to combine experimental data with in silico simulations to get a holistic view of vitamin D-dependent regulation of tissue and cell physiology. This review focus on binding characteristics for the three putative vitamin D receptors and proposes a future systems biology approach including mathematical modeling that will be helpful together with experimental methods in depicting antitumoral and other biological effects promoted by the vitamin D endocrine system.
Holmén
Jonathan
J
Systems Biology Research Centre, School of Life Sciences, University of Skövde, Skövde, Sweden.
Jansson
Andreas
A
Larsson
Dennis
D
D015650:24,25-Dihydroxyvitamin D 3 / Q000378:metabolism*; D000818:Animals; D002117:Calcitriol / Q000378:metabolism*; D006801:Humans; D018167:Receptors, Calcitriol / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D049490:Systems Biology; D014807:Vitamin D / Q000378:metabolism*; D014815:Vitamins / Q000378:metabolism*
D018167:Receptors, Calcitriol; D014815:Vitamins; D014807:Vitamin D; D015650:24,25-Dihydroxyvitamin D 3; D002117:Calcitriol