title: Bioactive constituents of the stem bark of Mitrephora glabra.
abstract: Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three ent-kaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.
authors.affiliation: Natural Products Laboratory, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, USA.
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
authors.forename: Tyler N
authors.initials: TN
authors.lastname: Graf
authors.forename: Sharnelle S
authors.initials: SS
authors.lastname: Phifer
authors.forename: Yuka
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: Soedarsono
authors.initials: S
authors.lastname: Riswan
authors.forename: Fransisca M
authors.initials: FM
authors.lastname: Setyowati
authors.forename: Achmad M
authors.initials: AM
authors.lastname: Saribi
authors.forename: Djaja D
authors.initials: DD
authors.lastname: Soejarto
authors.forename: Norman R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: Joseph O
authors.initials: JO
authors.lastname: Falkinham
authors.forename: David J
authors.initials: DJ
authors.lastname: Kroll
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn
authors.forename: Mansukh C
authors.initials: MC
authors.lastname: Wani
authors.forename: Nicholas H
authors.initials: NH
authors.lastname: Oberlies
mesh_terms: D029061:Annonaceae / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001060:Aporphines / Q000302:isolation & purification; D001234:Aspergillus niger / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007214:Indonesia; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D015394:Molecular Structure; D009161:Mycobacterium / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D053279:Polyynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; D004224:Diterpenes; D053279:Polyynes; C026980:liriodenine