Granzymes and perforin in solid organ transplant rejection.
Rejection of solid organ allografts by the recipient immune system is mediated, to a major extent, by T cell effector mechanisms. Granzymes and perforin are protein regulators of cytotoxic T lymphocyte-mediated target cell death. In this review, I discuss clinical data implicating granzymes and perforin in acute and chronic solid organ transplant rejection, as well as data from cell and animal experiments that support a main role for these effector molecules in allograft rejection.
Choy
J C
JC
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada. jonathan.choy@sfu.ca
D000818:Animals; D006084:Graft Rejection / Q000276:immunology*; D053804:Granzymes / Q000502:physiology*; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology; D007111:Immunity, Cellular / Q000502:physiology*; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D051379:Mice; D054353:Perforin / Q000502:physiology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014184:Transplantation, Homologous / Q000276:immunology
D054353:Perforin; D053804:Granzymes