title: Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet.
abstract: In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target disease-associated molecular defects. Recent developments prompted an international expert panel to provide updated evidence- and expert opinion-based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed.
authors.affiliation: Department of Internal Medicine III, University of Ulm, Ulm, Germany. hartmut.doehner@uniklinik-ulm.de
authors.forename: Hartmut
authors.initials: H
authors.lastname: Döhner
authors.forename: Elihu H
authors.initials: EH
authors.lastname: Estey
authors.forename: Sergio
authors.initials: S
authors.lastname: Amadori
authors.forename: Frederick R
authors.initials: FR
authors.lastname: Appelbaum
authors.forename: Thomas
authors.initials: T
authors.lastname: Büchner
authors.forename: Alan K
authors.initials: AK
authors.lastname: Burnett
authors.forename: Hervé
authors.initials: H
authors.lastname: Dombret
authors.forename: Pierre
authors.initials: P
authors.lastname: Fenaux
authors.forename: David
authors.initials: D
authors.lastname: Grimwade
authors.forename: Richard A
authors.initials: RA
authors.lastname: Larson
authors.forename: Francesco
authors.initials: F
authors.lastname: Lo-Coco
authors.forename: Tomoki
authors.initials: T
authors.lastname: Naoe
authors.forename: Dietger
authors.initials: D
authors.lastname: Niederwieser
authors.forename: Gert J
authors.initials: GJ
authors.lastname: Ossenkoppele
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Sanz
authors.forename: Jorge
authors.initials: J
authors.lastname: Sierra
authors.forename: Martin S
authors.initials: MS
authors.lastname: Tallman
authors.forename: Bob
authors.initials: B
authors.lastname: Löwenberg
authors.forename: Clara D
authors.initials: CD
authors.lastname: Bloomfield
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D006287:Health Planning Guidelines; D006801:Humans; D007391:International Cooperation; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D055815:Young Adult