Progesterone sperm chemoattraction may be modulated by its corticosteroid-binding globulin carrier protein.
Progesterone, the main steroidal component secreted by the cumulus cells that surround the egg, chemotactically guides human spermatozoa. The aim of this work was to evaluate whether the carrier protein corticosteroid-binding globulin also participates in the sperm P chemotactic response. By means of videomicroscopy and image analysis, we observed that corticosteroid-binding globulin modulates the chemotactic activity of P, when a solution of corticosteroid-binding globulin + P is at the nanomolar range.
Teves
Maria Eugenia
ME
Centro de Biología Celular y Molecular, Universidad Nacional de Córdoba, X5016GCA Córdoba, Argentina.
Guidobaldi
Hector Alejandro
HA
Uñates
Diego Rafael
DR
Sanchez
Raul
R
Miska
Werner
W
Giojalas
Laura Cecilia
LC
D002352:Carrier Proteins / Q000502:physiology; D002633:Chemotaxis / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D011374:Progesterone / Q000494:pharmacology*; D055101:Semen Analysis / Q000379:methods; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D014156:Transcortin / Q000494:pharmacology* / Q000502:physiology
D002352:Carrier Proteins; D011374:Progesterone; D014156:Transcortin