title: Transoral CO(2) laser treatment for T(is)-T(3) glottic cancer: the University of Brescia experience on 595 patients.
abstract: BACKGROUND
  Transoral CO(2) laser surgery has been accepted as a valuable therapeutic option for glottic cancer.
  
  
  METHODS
  This was a retrospective analysis of 595 patients. Five-year overall and disease-specific survivals, local control with laser, locoregional, regional control, and organ preservation rates were calculated. The impact of different variables was calculated by univariate analysis.
  
  
  RESULTS
  Overall, disease-specific and disease-free survivals, local control with laser, locoregional, regional control, and organ preservation rates were 87.5%, 99%, 81.3%, 92.7%, 98.9%, 98.2%, and 97.1%, respectively. Univariate analysis showed a significant impact of pT category on local control with laser, organ preservation, locoregional and regional control, of endoscopic re-treatment for positive deep surgical margins on local control with laser and organ preservation, and recurrence after endoscopic re-treatment on local control with laser and organ preservation.
  
  
  CONCLUSIONS
  This series confirms the good oncologic outcomes of endoscopic laser surgery for T(is), T(1), and selected T(2) and T(3) glottic tumors.
authors.affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy. g.peretti@tin.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: Peretti
authors.forename: Cesare
authors.initials: C
authors.lastname: Piazza
authors.forename: Daniela
authors.initials: D
authors.lastname: Cocco
authors.forename: Luigi
authors.initials: L
authors.lastname: De Benedetto
authors.forename: Francesca
authors.initials: F
authors.lastname: Del Bon
authors.forename: Luca Oscar
authors.initials: LO
authors.lastname: Redaelli De Zinis
authors.forename: Piero
authors.initials: P
authors.lastname: Nicolai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D015331:Cohort Studies; D018572:Disease-Free Survival; D004724:Endoscopy; D005260:Female; D005931:Glottis; D006801:Humans; D007558:Italy; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D007825:Laryngectomy; D054020:Lasers, Gas / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome