title: F1 (CBA×C57) mice show superior hearing in old age relative to their parental strains: hybrid vigor or a new animal model for "golden ears"?
abstract: Age-related hearing loss - presbycusis - is the most common communication problem and third most prevalent chronic medical disorder of the aged. The CBA and C57BL/6 mouse strains are useful for studying features of presbycusis. The CBA loses its hearing slowly, like most humans. Because the C57 develops a rapid, high frequency hearing loss by middle age, it has an "old" ear but a relatively young brain, a model that helps separate peripheral (cochlear) from central (brain) etiologies. This field of sensory neuroscience lacks a good mouse model for the 5-10% of aged humans with normal cochlear sensitivity, but who have trouble perceiving speech in background noise. We hypothesized that F1 (CBA×C57) hybrids would have better hearing than either parental strain. Measurements of peripheral auditory sensitivity supported this hypothesis, however, a rapid decline in the auditory efferent feedback system, did not. Therefore, F1s might be an optimal model for studying cases where the peripheral hearing is quite good in old age; thereby allowing isolation of central auditory changes due to brain neurodegeneration.
authors.affiliation: Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. Robert Frisina@urmc.rochester.edu
authors.forename: Robert D
authors.initials: RD
authors.lastname: Frisina
authors.forename: Ameet
authors.initials: A
authors.lastname: Singh
authors.forename: Matthew
authors.initials: M
authors.lastname: Bak
authors.forename: Sara
authors.initials: S
authors.lastname: Bozorg
authors.forename: Rahul
authors.initials: R
authors.lastname: Seth
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001306:Auditory Pathways / Q000503:physiopathology; D001947:Breeding / Q000379:methods*; D002678:Chimera / Q000502:physiology*; D004195:Disease Models, Animal; D004525:Efferent Pathways / Q000503:physiopathology; D005260:Female; D006313:Hearing Loss, Central / Q000235:genetics*; D006823:Hybrid Vigor / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013045:Species Specificity