BMP2 signaling in bone development and repair.
BMPs are best known for their actions as bone formation signals. Recent studies using transgenic mice in which individual osteogenic BMPs have been removed from the limb skeleton have identified BMP2 as a fundamental component of the inherent regenerative capacity of bone. This review summarizes current findings on the specific requirement for BMP2 in bone formation and repair.
Rosen
Vicki
V
Department of Developmental Biology, Harvard University School of Dental Medicine, Boston, MA 02115, USA. Vicki_rosen@hsdm.harvard.edu
D000328:Adult; D000818:Animals; D001846:Bone Development / Q000235:genetics* / Q000502:physiology; D055396:Bone Morphogenetic Protein 2 / Q000235:genetics / Q000502:physiology*; D001861:Bone Regeneration / Q000235:genetics* / Q000502:physiology; D001842:Bone and Bones / Q000502:physiology; D006801:Humans; D051379:Mice; D008954:Models, Biological; D010012:Osteogenesis / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2