title: Antimicrobial and cytotoxic activity of the alkaloids of Amlaki (Emblica officinalis).
abstract: Alkaloids are important sources of drug that's why we have conducted our research to find out the biological activity of the alkaloids of a plant that is the Amlaki. Alkaloids were extracted from the methanolic extract of the fresh ripe fruits of Amlaki (Emblica officinalis) through solvent-solvent partitioning method with n-hexane and chloroform. The chloroform soluble fraction of the crude methanolic extract of the ripe fruits of Amlaki containing alkaloids was subjected to antimicrobial activity and brine shrimp lethality bioassay for observing cytotoxic activity. The chloroform soluble fraction of the methanolic extract exhibited significant antimicrobial activity against some Gram positive and Gram negative pathogenic bacteria and strong cytotoxicity having a LC50 of 10.257 +/- 0.770 microg mL(-1). It is concluded that the chloroform soluble fraction of the ripe fruits of Amlaki containing alkaloids are biologically active.
authors.affiliation: Department of Pharmacy, School of Science and Engineering, Southeast University, Banani, Dhaka-1213, Bangladesh.
authors.forename: S
authors.initials: S
authors.lastname: Rahman
authors.forename: M M
authors.initials: MM
authors.lastname: Akbor
authors.forename: A
authors.initials: A
authors.lastname: Howlader
authors.forename: A
authors.initials: A
authors.lastname: Jabbar
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D005638:Fruit / Q000737:chemistry; D006801:Humans; D008826:Microbial Sensitivity Tests; D029842:Phyllanthus emblica / Q000033:anatomy & histology / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; D010936:Plant Extracts