title: Alkyl and dialkylaminoethyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes and their antiplasmodial and antitrypanosomal activities.
abstract: N-Alkyl and N-(2-dialkylaminoethyl) derivatives of 5-amino-2-azabicyclo-nonanes were prepared and tested in vitro for their activities against the multidrug-resistant K1 strain of Plasmodium falciparum and Trypanosoma brucei rhodesiense (STIB 900). Most of the new compounds showed lower antitrypanosomal activity than their parent compounds. With respect to their activity against P. falciparum the N-alkyl derivatives exhibited worse selectivity due to decreased antiplasmodial activity or higher cytotoxicity. In comparison all of the new N-(2-dialkylaminoethyl) analogues possessed a much better selectivity and a single of these compounds showed even better antiplasmodial activity and selectivity than chloroquine.
authors.affiliation: Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens-University, Universitätsplatz 1, A-8010 Graz, Austria.
authors.forename: Johanna
authors.initials: J
authors.lastname: Faist
authors.forename: Werner
authors.initials: W
authors.lastname: Seebacher
authors.forename: Marcel
authors.initials: M
authors.lastname: Kaiser
authors.forename: Reto
authors.initials: R
authors.lastname: Brun
authors.forename: Robert
authors.initials: R
authors.lastname: Saf
authors.forename: Robert
authors.initials: R
authors.lastname: Weis
mesh_terms: D000473:Alkanes / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D057927:Hydrophobic and Hydrophilic Interactions; D020128:Inhibitory Concentration 50; D009584:Nitrogen / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D051381:Rats; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects
chemical_list: D000473:Alkanes; D000981:Antiprotozoal Agents; D009584:Nitrogen; C017573:nonane