Molecular identification of phaeohyphomycosis due to Alternaria infectoria in a patient with acute myeloid leukemia--a case report.
We report the case of a 15-year old with acute myeloid leukemia who developed breakthrough invasive fungal rhinitis. The fungus was identified as Alternaria infectoria by polymerase chain reaction (PCR) and successfully treated by surgical excision and combination antifungal therapy, emphasizing the utility of fungal PCR in timely diagnosis of invasive fungal infections.
Leahy
T Ronan
TR
Genomic Research Laboratory, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James's Hospital, James's St, Dublin, Ireland. leahyt@tcd.ie
Punnett
Angela S
AS
Richardson
Susan E
SE
Gharabaghi
Farhad
F
Wadhwa
Anupma
A
D000293:Adolescent; D000528:Alternaria / Q000235:genetics* / Q000302:isolation & purification; D000935:Antifungal Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003561:Cytarabine / Q000627:therapeutic use; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000382:microbiology*; D009181:Mycoses / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D009296:Nasal Cavity / Q000382:microbiology; D016133:Polymerase Chain Reaction; D012220:Rhinitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D014740:Vidarabine / Q000031:analogs & derivatives / Q000627:therapeutic use
D000935:Antifungal Agents; D003561:Cytarabine; D016179:Granulocyte Colony-Stimulating Factor; D014740:Vidarabine