title: Effects of flavangenol on autonomic nerve activities and dietary body weight gain in rats.
abstract: In a previous report, evidence was presented that flavangenol supplementation has an anti-ischemic effects in rats. In the study presented here, we examined the autonomic effects of intraduodenal (ID) injection of flavangenol in urethane-anesthetized rats and found that it increased sympathetic nerve activity innervating brown adipose tissue (BAT-SNA) in a dose-dependent manner, while it suppressed gastric vagal nerve activity (GVNA). In addition, intra-oral (IO) injection of flavangenol elevated brown adipose tissue temperature (BAT-T). Furthermore, flavangenol drinking for 15 d reduced body weight gain in rats fed a high-fat diet. These results thus suggest that flavangenol supplementation exerts its reducing action on body weight through changes in autonomic neurotransmission.
authors.affiliation: Institute for Protein Research, Osaka University, Suita, Osaka, Japan. mtanida@sk.ritsumei.ac.jp
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tanida
authors.forename: Nobuo
authors.initials: N
authors.lastname: Tsuruoka
authors.forename: Jiao
authors.initials: J
authors.lastname: Shen
authors.forename: Yuko
authors.initials: Y
authors.lastname: Horii
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Beppu
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kiso
authors.forename: Katsuya
authors.initials: K
authors.lastname: Nagai
mesh_terms: D052437:Adipocytes, Brown / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000502:physiology*; D044946:Biflavonoids / Q000008:administration & dosage / Q000494:pharmacology*; D004032:Diet / Q000009:adverse effects*; D004041:Dietary Fats / Q000009:adverse effects; D004435:Eating / Q000187:drug effects; D008297:Male; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D044945:Proanthocyanidins / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects / Q000294:innervation; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D013696:Temperature; D013997:Time Factors; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D044946:Biflavonoids; D004041:Dietary Fats; D044945:Proanthocyanidins; C504746:flavangenol