Glioblastoma multiforme in a patient with chronic granulomatous disease treated with subtotal resection, radiation, and thalidomide: case report of a long-term survivor.
We report on a child with chronic granulomatous disease who at the age of 13 years was diagnosed with glioblastoma multiforme of the left thalamus. Therapy included subtotal resection, radiation to the tumor bed (60 Gy), and concomitant chemotherapy with daily thalidomide (250 mg/m2), both during radiation and for 5 years thereafter. Currently, she is 9 years from diagnosis and has no evidence of disease. Therapy with thalidomide did not increase her infection complications and provided excellent quality of life. This is the first report of glioblastoma multiforme in a patient with chronic granulomatous disease treated with surgery, radiation, and thalidomide who is a long-term survivor.
Aguilera
Dolly G
DG
Division of Hematology-Oncology and Stem Cell Transplantation, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA.
Tomita
Tadanori
T
Rajaram
Veena
V
Fangusaro
Jason
J
Katz
Ben Z
BZ
Shulman
Stanford
S
Goldman
Stewart
S
D000293:Adolescent; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D003399:Craniotomy; D003937:Diagnosis, Differential; D005260:Female; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D006105:Granulomatous Disease, Chronic / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D006801:Humans; D011788:Quality of Life; D011829:Radiation Dosage; D017741:Survivors; D013792:Thalidomide / Q000627:therapeutic use*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D013792:Thalidomide