title: [Mold fungi and the role of allergy on fungi in chronic rhinosinusitis].
abstract: OBJECTIVE
  The aim of this work was to assessment the role of mould fungi and the allergy on fungi in chronic rhinosinusitis.
  
  
  METHODS
  We studied 30 patients with chronic rhinosinusitis with or without polyposis who underwent endoscopic nose and sinuses procedures. Clinical and immunological workup was performed for atopy in all patients. We performed CT of the sinuses, skin-prick testing on 15 fungal allergens, total IgE and fungal-specific IgE levels, eosinophilia level. Specimens were sent for mycology and histopathologic analysis for identification of fungi.
  
  
  RESULTS
  Fungal culture from sinuses were negative in all patients. Bacterial culture were positive in 19 cases. There was observed elevated total immunoglobulin E level in 70% of patients. Positive skin test reactivity for fungal allergen was observed in 7 patients--3 for Aspergillus, 2 for Alternaria and 2 for Cladosporium. Fungal specific IgE levels were below 0.35 KU/L in all patients. Nasal polyps were found in 26 patients, they were associated with asthma and aspirin intollerance. No fungal hyphae were found in histopathologic analysis.
  
  
  CONCLUSIONS
  Our preliminary study suggest, that allergy for fungi doesn't play a significant role in etiology and pathogenesis of the chronic rhinosinusitis with or without polyps. We did't find any case of the allergic fungal sinusitis in our patients.
authors.affiliation: Klinika Otolaryngologii Uniwersytetu Medycznego w Białymstoku. mrkud@op.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Rózańska-Kudelska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Sieśiewicz
authors.forename: Barbara
authors.initials: B
authors.lastname: Południewska
authors.forename: Magdalena
authors.initials: M
authors.lastname: Kania
authors.forename: Izabela
authors.initials: I
authors.lastname: Michalczuk
authors.forename: Marek
authors.initials: M
authors.lastname: Rogowski
mesh_terms: D000328:Adult; D000368:Aged; D015169:Colony Count, Microbial; D005260:Female; D005658:Fungi / Q000302:isolation & purification*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000382:microbiology*; D009297:Nasal Mucosa / Q000382:microbiology; D011044:Poland; D012220:Rhinitis / Q000175:diagnosis / Q000382:microbiology* / Q000601:surgery; D012852:Sinusitis / Q000175:diagnosis / Q000382:microbiology* / Q000601:surgery; D012882:Skin Tests; D014057:Tomography, X-Ray Computed
chemical_list: D007073:Immunoglobulin E