title: Genetic diversity of feline cowpox virus, Germany 2000-2008.
abstract: Recent cowpox virus (CPXV) infections of humans in Europe transmitted from cats and pet rats have risen public awareness of this rare zoonosis. Based on serosurveys wild rodents are regarded as primary reservoir hosts. Cats can become infected while hunting and could therefore serve as a sentinel for CPXV strains circulating in wild rodents. In a retrospective study we analysed 73 formalin-fixed paraffin-embedded skin samples from cats with a histologically proven CPXV infection. Specimens had been collected in different parts of Germany during 2000-2008. Following DNA extraction part of the hemagglutinin gene was amplified and sequenced from 72 samples. A phylogenetic analysis was inferred resulting in a total of 21 different CPXV genetic variants. The geographic distribution was imposed on a map.
authors.affiliation: Bundeswehr Institute of Microbiology, Neuherbergstrasse 11, D-80937 Munich, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Kaysser
authors.forename: Wolf
authors.initials: W
authors.lastname: von Bomhard
authors.forename: Linda
authors.initials: L
authors.lastname: Dobrzykowski
authors.forename: Hermann
authors.initials: H
authors.lastname: Meyer
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000453:epidemiology / Q000821:virology*; D002415:Cats; D015605:Cowpox / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D015608:Cowpox virus / Q000235:genetics*; D014644:Genetic Variation; D005858:Germany / Q000453:epidemiology; D006389:Hemagglutinins, Viral / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D010802:Phylogeny; D012189:Retrospective Studies; D012621:Seasons
chemical_list: D006389:Hemagglutinins, Viral