Copper-catalyzed synthesis of 2-unsubstituted, N-substituted benzimidazoles.
An efficient copper-catalyzed intramolecular arylation of formamidines forming 2-unsubstituted benzimidazoles in excellent yields is reported. Sixteen examples bearing sterically demanding substituents on nitrogen like Mes, 2,6-diisopropylphenyl, or 2-tert-butylphenyl and tolerating various functional groups demonstrate the utility of this method.
Hirano
Keiichi
K
Organisch-Chemisches Institut der Westfälischen Wilhelms-Universität Münster, Germany.
Biju
Akkattu T
AT
Glorius
Frank
F