Relationship between functional activity of the thyroid gland and levels of proinflammatory and immunoregulatory cytokines in acute experimental endotoxicosis.
Functional activity of the thyroid gland is reduced in Wistar rats with acute experimental endotoxicosis developing in response to sublethal dose of LPS and paralleled by polarization of the immune response by the Th-1 type. This decrease does not depend on the level of thyrotropic hormone and correlates with the production of IL-2 and IFN-gamma.
Yaglova
N V
NV
Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia. yaglova@mail.ru
D000818:Animals; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism / Q000494:pharmacology*; D019446:Endotoxemia / Q000139:chemically induced* / Q000276:immunology* / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D007371:Interferon-gamma / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism*; D013963:Thyroid Hormones / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D007376:Interleukin-2; D008070:Lipopolysaccharides; D013963:Thyroid Hormones; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma