The rat spermatogenesis after injection of paclitaxel (antitumor agent).
Morphological and functional characteristics of spermatogenesis in rats were studied during the early and delayed periods after single injection of paclitaxel (antitumor agent) in the maximum tolerated dose. The drug induced structural changes in the gonads associated with oligospermia and increased number of pathological forms of spermatozoa with reduced functional activity.
Borovskaya
T G
TG
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia. igdoca@mail.ru
Goldberg
V E
VE
Rumpel
O A
OA
Pahomova
A V
AV
Perova
A V
AV
Goldberg
E D
ED
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects* / Q000494:pharmacology*; D008297:Male; D009845:Oligospermia / Q000139:chemically induced; D017239:Paclitaxel / Q000494:pharmacology*; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects / Q000502:physiology
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel