[Cycloartane triterpenoid of Cimicifuga foetida].
OBJECTIVE
To study cycloartane triterpenoid of Cimicifuga foetida and their osteoclast inhibition activity.


METHODS
The compounds were isolated and purified by normal and reversed phase column chromatographic methods. Structures were identified by spectroscopic analyses. Their osteoclast inhibition activity was then studied.


RESULTS
Thirteen cycloartane triterpenoids were isolated from the rhizomes of C. foetida and were characterized as 25-O-acetyl-cimigenol (1), cimigenol (2), cimicidanol (3), 26-deoxyactein (4), asiaticoside A (5), 23-epi-26-deoxyactein (6), actein (7), 12beta-hydroxycimigenol (8), cimiside E (9), (23R, 24S) 25-O-acetyl-cimigenol-3-O-beta-D-xylopyranoside (10), (23R, 24S) cimigenol-3-O-beta-D-xylopyranoside (11), cimicifugoside H-1 (12) and cimicifugoside H-2 (13).


CONCLUSIONS
Compound 5 was isolated from this genus for the first time, compound 7 was isolated firstly from the plant and compound 2, 7, 10 and 11 exhibit osteoclast inhibition activity.
Dan
Chun
C
College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China. danc999@163.com
Liang
Jian
J
Zhou
Yan
Y
Ding
Lisheng
L
D000818:Animals; D002478:Cells, Cultured; D031885:Cimicifuga / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D010010:Osteoclasts / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C085352:cycloartane