Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines.
Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.
Rives
Arnaud
A
Université Paul Sabatier, UMR CNRS 5068, Laboratoire de Synthèse et Physicochimie de Molécules d'Intérêt Biologique, 118 route de Narbonne, 31062 Toulouse Cédex 9, France.
Le Calvé
Benjamin
B
Delaine
Tamara
T
Legentil
Laurent
L
Kiss
Robert
R
Delfourne
Evelyne
E
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D009792:Oceans and Seas; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D011804:Quinolines