An amphiphilic ruthenium(II)-polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent.
An amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0+/-26.8GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section.
Poon
Chun-Ting
CT
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China.
Chan
Pui-Shan
PS
Man
Cornelia
C
Jiang
Feng-Lei
FL
Wong
Ricky Ngok Shun
RN
Mak
Nai-Ki
NK
Kwong
Daniel W J
DW
Tsao
Sai-Wah
SW
Wong
Wai-Kwok
WK
D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D006801:Humans; D021621:Imaging, Three-Dimensional; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use; D010778:Photochemotherapy; D017785:Photons; D017319:Photosensitizing Agents / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use; D013050:Spectrometry, Fluorescence
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; C547388:bis(bipyridine)(((10',15',20'-triphenyl)porphyrin(5'-p-phenoxy-5-ethanamido))-1,10-phenanthroline)ruthenium(II)