Acetylsalicylic acid as a modulator of neutrophil peroxidase system.
Effect of acetylsalycilic acid (aspirin; Ron-Pulenk) on activity of mouse neutrophil peroxydase system was investigated. Using luminol-dependent chemiluminscence and cytochemical methods we demonstrated that neutrophil peroxydase system in mice receiving aspirin for 14 days is probably determined by stimulation of myeloperoxydase synthesis.
Mushtakova
V M
VM
N. N. Semenov Institute of Chemical Physics of Russian Academy of Sciences, Moscow, Russia. kar12255@orc.ru
Fomina
V A
VA
Rogovin
V V
VV
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology*; D009195:Peroxidase / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009195:Peroxidase; D001241:Aspirin