title: Linking hippocampal structure and function to memory performance in an aging population.
abstract: BACKGROUND
  Hippocampal atrophy and reductions in basal cerebral blood volume (CBV), a hemodynamic correlate of brain function, occur with cognitive impairment in Alzheimer disease, but whether these are early or late changes remains unclear. Magnetic resonance imaging is used to assess structure and function in the hippocampal formation.
  
  
  OBJECTIVE
  To estimate differences in the associations of hippocampal and entorhinal cortex volumes and CBV with memory function in the early and late stages of cognitive impairment by relating these measures to memory function in persons with and without dementia who underwent detailed brain imaging and neuropsychological assessment.
  
  
  METHODS
  Multivariate regression analyses were used to relate entorhinal cortex volume, entorhinal cortex CBV, hippocampal volume, and hippocampal CBV to measurements of memory performance. The same measures were related to language function as a reference cognitive domain.
  
  
  METHODS
  Community-based cohort.
  
  
  METHODS
  Two hundred thirty-one elderly Medicare recipients (aged > or =65 years) residing in northern Manhattan, New York.
  
  
  METHODS
  Values for entorhinal cortex volume, hippocampal volume, entorhinal cortex CBV, and hippocampal CBV and their relation to memory performance.
  
  
  RESULTS
  No association was noted between entorhinal cortex volume or hippocampal CBV and memory. Decreased hippocampal volume was strongly associated with worse performance in total recall, and lower entorhinal cortex CBV was associated with lower performance in delayed recall. Excluding persons with Alzheimer disease, the association of entorhinal cortex CBV with memory measures was stronger, whereas the association between hippocampal volume and total recall became nonsignificant.
  
  
  CONCLUSIONS
  In the early stages of Alzheimer disease or in persons without dementia with worse memory ability, functional and metabolic hippocampal hypofunction contributes to memory impairment, whereas in the later stages, functional and structural changes play a role.
authors.affiliation: Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. cr2101@columbia.edu
authors.forename: Christiane
authors.initials: C
authors.lastname: Reitz
authors.forename: Adam M
authors.initials: AM
authors.lastname: Brickman
authors.forename: Truman R
authors.initials: TR
authors.lastname: Brown
authors.forename: Jennifer
authors.initials: J
authors.lastname: Manly
authors.forename: Charles
authors.initials: C
authors.lastname: DeCarli
authors.forename: Scott A
authors.initials: SA
authors.lastname: Small
authors.forename: Richard
authors.initials: R
authors.lastname: Mayeux
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology; D015331:Cohort Studies; D005260:Female; D006624:Hippocampus / Q000098:blood supply / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000503:physiopathology*; D009483:Neuropsychological Tests