Anti-inflammatory effect of the polysaccharides of golden needle mushroom in burned rats.
The present study was to investigate chemical components of polysaccharides isolated from Golden needle (GNP) mushroom using high performance liquid chromatography (HPLC) and nuclear magnetic resonance spectroscopy (NMR). Then, anti-inflammatory effect of the polysaccharides was also evaluated. Results indicated that GNP was composed of the three monosaccharides (glucose, mannose and xylose) with a molar ratio of 3.5:0.8:1.4. GNP could significantly decreased CD4+ CD8+, ICAM-1, and MPO in serum and colon of normal and burned rats. It could be concluded that GNP possessed strong anti-inflammatory activity in burned rats.
Wu
Dong-mei
DM
Department of Plastic and Burns Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, PR China.
Duan
Wei-qiang
WQ
Liu
Yong
Y
Cen
Ying
Y
D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002056:Burns / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology; D015704:CD4 Antigens / Q000097:blood; D016827:CD8 Antigens / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D003106:Colon / Q000378:metabolism; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008970:Molecular Weight; D009195:Peroxidase / Q000097:blood; D011134:Polysaccharides / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D015704:CD4 Antigens; D016827:CD8 Antigens; D011134:Polysaccharides; D018799:Intercellular Adhesion Molecule-1; D016753:Interleukin-10; D009195:Peroxidase