title: Successful treatment of retroperitoneal infantile hemangioendothelioma with Kasabach-Merritt syndrome using steroid, alpha-interferon, and vincristine.
abstract: Infantile hemangioendothelioma (IHE) is a rare benign vascular tumor with potentially life-threatening complications. Various therapeutic options have been recommended according to the site, extent, and behavior of the IHE. Because of the slow and unpredictable response to treatment with using a single drug in critically ill patients, there is a tendency to administer drugs in combination to treat this disease. Here, we report on a 1-month-old female infant who had a retroperitoneal IHE with Kasabach-Merritt syndrome and she was successfully treated with a combination of steroid, interferon-alpha, and vincristine.
authors.affiliation: Department of Pediatrics, Kyung Hee University Medical Center, Seoul, Korea.
authors.forename: Hoi Soo
authors.initials: HS
authors.lastname: Yoon
authors.forename: Jae Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Hyung Nam
authors.initials: HN
authors.lastname: Moon
authors.forename: Jong Jin
authors.initials: JJ
authors.lastname: Seo
authors.forename: Ho Joon
authors.initials: HJ
authors.lastname: Im
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Goo
mesh_terms: D003937:Diagnosis, Differential; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006390:Hemangioendothelioma / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D016898:Interferon-alpha / Q000627:therapeutic use*; D008775:Methylprednisolone / Q000627:therapeutic use*; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy*; D013577:Syndrome; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use*
chemical_list: D016898:Interferon-alpha; D014750:Vincristine; D008775:Methylprednisolone