title: Progression of age-related macular degeneration after cataract surgery.
abstract: OBJECTIVE
  To document age-related macular degeneration (AMD) progression after cataract surgery.
  
  
  METHODS
  Surgeons prospectively enrolled patients with nonneovascular AMD who were awaiting cataract surgery. Fluorescein angiography was performed preoperatively and at the postoperative week 1, month 3, and month 12 visits. Incidence of neovascular AMD development within 12 months after operation was the primary outcome measure.
  
  
  RESULTS
  A total of 108 subjects were enrolled. Of 86 eyes with preoperatively photographically confirmed nonneovascular AMD, 71 had gradable images by month 12. Neovascular AMD was observed in 9 of 71 eyes (12.7%; 95% confidence interval, 6.0%-22.7%). The progression rate between week 1 and month 12 decreased to 3 of 65 eyes (4.6%; 95% confidence interval, 1.0%-12.9%) after excluding 5 neovascular events identified on the postoperative week 1 visit and 1 case with missing photographs at this visit.
  
  
  CONCLUSIONS
  The low incidence rate of neovascular AMD development between 1 week and 1 year after cataract surgery did not support the hypothesis that cataract surgery increases the risk of AMD progression. Several eyes appeared to have disease progression on postsurgery week 1 fluorescein angiograms, suggesting that many cases of presumed progression to neovascular AMD following cataract surgery may have been present prior to cataract surgery, but not recognized owing to lens opacity.
authors.affiliation: Department of Preventive Medicine, Stony Brook University School of Medicine, USA.
authors.forename: Li Ming
authors.initials: LM
authors.lastname: Dong
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Stark
authors.forename: Joan L
authors.initials: JL
authors.lastname: Jefferys
authors.forename: Selwa
authors.initials: S
authors.lastname: Al-Hazzaa
authors.forename: Susan B
authors.initials: SB
authors.lastname: Bressler
authors.forename: Sharon D
authors.initials: SD
authors.lastname: Solomon
authors.forename: Neil M
authors.initials: NM
authors.lastname: Bressler
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000150:complications*; D004396:Coloring Agents; D018450:Disease Progression; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007208:Indocyanine Green; D019654:Lens Implantation, Intraocular; D008268:Macular Degeneration / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011183:Postoperative Complications; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green