Serum anti-GAGA4 IgM antibodies differentiate relapsing remitting and secondary progressive multiple sclerosis from primary progressive multiple sclerosis and other neurological diseases.
The serum level of IgM antibodies against Glc(alpha1,4)Glc(alpha) (GAGA4) is higher in relapsing remitting multiple sclerosis (RRMS) compared to other neurological disease (OND) patients and healthy controls (HC). Detecting the level of anti-GAGA4 antibody by enzyme immunoassay and total IgM, we confirmed that anti-GAGA4 IgM can differentiate RRMS from OND patients and HC. Moreover, secondary progressive MS (SPMS) and RRMS patients have similar levels of anti-GAGA4 demonstrating the biomarker's presence throughout the disease. Interestingly, the anti-GAGA4 assay may also differentiate between primary progressive MS (PPMS) and RRMS/SPMS patients, since nearly all PPMS patients were negative for the assay.
Brettschneider
Johannes
J
Department of Neurology, University of Ulm, Ulm, Germany.
Jaskowski
Troy D
TD
Tumani
Hayrettin
H
Abdul
Sana
S
Husebye
Dee
D
Seraj
Haniah
H
Hill
Harry R
HR
Fire
Ella
E
Spector
Larissa
L
Yarden
Jennifer
J
Dotan
Nir
N
Rose
John W
JW
D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D005947:Glucose / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000097:blood* / Q000175:diagnosis; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000175:diagnosis; D009422:Nervous System Diseases / Q000097:blood* / Q000175:diagnosis; D009844:Oligosaccharides / Q000276:immunology*; D018709:Statistics, Nonparametric
D007075:Immunoglobulin M; D009844:Oligosaccharides; C033620:glucose tetrasaccharide; D005947:Glucose