title: Early follicle development during the luteal-follicular transition affects the predictability of serum follicle-stimulating hormone but not antimüllerian hormone levels on cycle day 3.
abstract: OBJECTIVE
  To verify whether the presence of an overdeveloped antral follicle modifies the expected relationship between serum antimüllerian hormone (AMH), estradiol, or follicle-stimulating hormone (FSH) levels and antral follicle count on cycle day 3.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Teaching hospital, France.
  
  
  METHODS
  Two hundred seventy-seven normo-ovulating women.
  
  
  METHODS
  Serum AMH, estradiol, and FSH levels and the number and size of antral follicles (3 to 12 mm) were measured on cycle day 3. Two groups were set according to the presence ("large" group) or absence ("small" group) of at least one follicle measuring >7 mm.
  
  
  METHODS
  Hormonal-follicular correlation.
  
  
  RESULTS
  Whereas, as expected, the correlation between FSH and follicle counts was affected by the presence of an overdeveloped follicle, the correlation between AMH and follicle counts remained unaffected. Estradiol failed to be correlated with antral follicle counts in both groups.
  
  
  CONCLUSIONS
  In contrast with FSH, AMH levels remain tightly correlated to the number of antral follicles despite the presence of early growing follicles on cycle day 3.
authors.affiliation: AP-HP, Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Clamart, France.
authors.forename: Michael
authors.initials: M
authors.lastname: Grynberg
authors.forename: Vanessa
authors.initials: V
authors.lastname: Genro
authors.forename: Vanessa
authors.initials: V
authors.lastname: Gallot
authors.forename: Abdelwahab
authors.initials: A
authors.lastname: El-Ali
authors.forename: Rene
authors.initials: R
authors.lastname: Frydman
authors.forename: Renato
authors.initials: R
authors.lastname: Fanchin
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D002452:Cell Count; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D005498:Follicular Phase / Q000502:physiology*; D006801:Humans; D008183:Luteal Phase / Q000502:physiology*; D006080:Ovarian Follicle / Q000166:cytology / Q000000981:diagnostic imaging / Q000502:physiology*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D013997:Time Factors; D014463:Ultrasonography
chemical_list: D004958:Estradiol; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone