C-reactive protein and interleukin-6 responses for differentiating fungal and bacterial aetiology in late-onset neonatal sepsis.
Fungal infections are increasingly frequent causes of neonatal sepsis (NS). This study examined the predictive value of the combined evaluation of the C-reactive protein (CRP) and interleukin-6 (IL-6) responses for differentiating fungal and bacterial aetiologies in patients with NS. From January to September 2007, neonates who were diagnosed with NS and had their CRP and IL-6 levels measured were selected. Based on their blood culture results, the neonates were divided into two groups: group of fungal sepsis (FS) and group of bacterial sepsis (BS). FS included 14 Candida albicans and one non-albicans Candida isolates and BS included five Klebsiella pneumoniae, three Pseudomonas aeruginosa, three Enterococcus faecalis, two coagulase-negative Staphylococcus species, one Enterococcus faecium and one Acinetobacter species. Significant differences were observed in the CRP (FS vs. BS: 28.10 ± 11.03 vs. 11.39 ± 2.94 mg l(-1), P = 0.026) and IL-6 (FS vs. BS: 38.60 ± 24.24 vs. 392.82 ± 102.46 ng l(-1), P = 0.000) levels between groups. The combined evaluation of the CRP and IL-6 responses better predicted the causative micro-organism in NS.
Oguz
Suna Serife
SS
Dr. Zekai Tahir Burak Women's Health, Education and Research Hospital, NICU, Ankara, Turkey. serifesuna@gmail.com
Sipahi
Erden
E
Dilmen
Ugur
U
D016470:Bacteremia / Q000175:diagnosis* / Q000473:pathology; D001419:Bacteria / Q000145:classification / Q000302:isolation & purification; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D002175:Candida / Q000145:classification / Q000302:isolation & purification; D058387:Candidemia / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D011237:Predictive Value of Tests; D018805:Sepsis / Q000175:diagnosis* / Q000382:microbiology*
D015415:Biomarkers; D015850:Interleukin-6; D002097:C-Reactive Protein