Delayed nootropic effects of arginine vasopressin after early postnatal chronic administration to albino rat pups.
Intranasal administration of arginine vasopressin (10 microg/kg) to albino rat pups had a strong nootropic effect during training with positive and negative reinforcement. This effect was different in animals of various age groups: training with positive reinforcement was improved in "adolescent" rats and pubertal animals, while during training with negative reinforcement, the nootropic effect of the peptide was more prolonged and persisted also in adult animals.
Kim
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Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia. polina.kim@gmail.com
Voskresenskaya
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Kamensky
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D000281:Administration, Intranasal; D000818:Animals; D000831:Animals, Newborn; D001127:Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D005260:Female; D008297:Male; D018697:Nootropic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012054:Reinforcement, Psychology; D013997:Time Factors
D018697:Nootropic Agents; D001127:Arginine Vasopressin