Are biofilms the answer in the pathophysiology and treatment of chronic rhinosinusitis?
Chronic rhinosinusitis is a complex heterogeneous disease. Infection in the form of biofilm may have an important, if not central, role in the maintenance of the recalcitrant inflammation for this increasingly common chronic disease. Therefore, the importance of understanding the interaction of biofilm disease with the respiratory mucosa is imperative. Novel, minimally invasive methods of testing for the presence of this form of disease will need to become clinically accessible in order for equally innovative therapies to be widely applicable.
Kilty
Shaun J
SJ
Department of Otolaryngology-Head and Neck Surgery, University of Ottawa, Ottawa Hospital, Civic Campus, 1053 Carling Avenue, Ottawa, Ontario K1Y4E9, Canada.
Desrosiers
Martin Y
MY
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development*; D002908:Chronic Disease; D004198:Disease Susceptibility; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D011110:Polymorphism, Genetic; D011552:Pseudomonas Infections / Q000150:complications / Q000276:immunology* / Q000628:therapy; D011550:Pseudomonas aeruginosa / Q000502:physiology*; D020545:Respiratory Mucosa; D012220:Rhinitis / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D012852:Sinusitis / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D013203:Staphylococcal Infections / Q000150:complications / Q000276:immunology* / Q000628:therapy; D013211:Staphylococcus aureus / Q000502:physiology*
D000900:Anti-Bacterial Agents