title: Nuclear factor-kappaB expression as a novel marker of radioresistance in early-stage laryngeal cancer.
abstract: BACKGROUND
  The aim of this study was to evaluate the significance of nuclear factor-kappa B (NF-kappaB) expression as a marker of radioresistance in early-stage laryngeal cancer.
  
  
  METHODS
  Thirty-five patients with local recurrence and 70 case-matched patients without local recurrence were entered in this study. NF-kappaB expression was compared with Bcl-2 and epidermal growth factor (EGF) receptor expression by immunohistochemistry, using pretreatment biopsy specimens. The prognostic value of NF-kappaB was also evaluated. Twenty-nine recurrent tumors were compared with pretreatment tumors.
  
  
  RESULTS
  NF-kappaB expression in pretreatment tumors significantly correlated with local tumor control (p = .01), but bcl-2 and EGF receptor expression did not. Only NF-kappaB expression showed prognostic significance for local tumor control in both univariate and multivariate analyses (p = .008 and .04, respectively). NF-kappaB expression was markedly enhanced in 23 of 29 (80%) recurrent tumors.
  
  
  CONCLUSIONS
  NF-kappaB expression may be a novel marker of radioresistance in early-stage laryngeal cancer.
authors.affiliation: Division of Radiation Oncology, Kobe University Graduate School of Medicine, Hyogo, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Yoshida
authors.forename: Ryohei
authors.initials: R
authors.lastname: Sasaki
authors.forename: Hideki
authors.initials: H
authors.lastname: Nishimura
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Yoko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kawabe
authors.forename: Miki
authors.initials: M
authors.lastname: Saito
authors.forename: Naoki
authors.initials: N
authors.lastname: Otsuki
authors.forename: Yoshitake
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Toshinori
authors.initials: T
authors.lastname: Soejima
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nibu
authors.forename: Kazuro
authors.initials: K
authors.lastname: Sugimura
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D016022:Case-Control Studies; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local / Q000378:metabolism; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D011836:Radiation Tolerance
chemical_list: D014408:Biomarkers, Tumor; D016328:NF-kappa B; D019253:Proto-Oncogene Proteins c-bcl-2; D066246:ErbB Receptors