Effects of Chinese herbal medicine combined with He-Ne laser on lipoperoxide and superoxide dismutase in chloasma patients.
OBJECTIVE
To observe the effects of Chinese decoction and ligustrazin hydrochloride injection combined with He-Ne laser on lipoperoxide (LPO) and Superoxide dismutase (SOD) in patients with chloasma.


METHODS
90 cases of chloasma were randomly divided into the following two groups: a treatment group (of 54 cases) treated by a self-prepared prescription for toning the kidneys and relieving the depressed liver to remove blood stasis, ligustrazin hydrochloricde injection and He-Ne laser therapy, and a control group (of 36 cases) treated with oral administration of Vitamin E and Vitamin C plus external application of 20% Azelaic acid cream.


RESULTS
The total effective rate in the treatment group was 79.6%, which was significantly higher than that of the control group (P < 0.05). After treatment, the LPO level in the treatment group was significantly lowered (P < 0.01), and the SOD level was significantly elevated (P < 0.05).


CONCLUSIONS
The therapeutic methods adopted in the treatment group may show the action of antioxidation, providing good clinical effects for treating chloasma.
Wu
Yan-Hua
YH
Department of Chinese Medicine, Guangzhou Red Cross Hospital, Guangzhou 510220, China.
Li
Qi-Lin
QL
Yang
Xiu-Wen
XW
D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008054:Lipid Peroxides / Q000097:blood*; D008548:Melanosis / Q000097:blood / Q000628:therapy*; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood*; D016896:Treatment Outcome; D055815:Young Adult
D004365:Drugs, Chinese Herbal; D008054:Lipid Peroxides; D013482:Superoxide Dismutase