Effects of acetylsalicylic acid on serum paraoxonase activity, Ox-LDL, coenzyme Q10 and other oxidative stress markers in healthy volunteers.
OBJECTIVE
The aim of the study was to examine the effects of acetylsalicylic acid (ASA) on oxidative stress in healthy volunteers.


METHODS
30 volunteers of which 17 received ASA as 100 mg/day (Group I) and 13 received ASA as 150 mg/day (Group II) for 2 months. Serum paraoxonase 1 (PON1), arylesterase, total antioxidant status (TAS), total oxidant status (TOS), oxidized LDL (Ox-LDL) and coenzyme Q(10) (CoQ(10)) levels were measured before and 1 and 2 months after treatment.


RESULTS
There was no significant differences between the measured parameters of the groups. However, TOS and Ox-LDL levels of group II were significantly reduced after 2 months of treatment (p<0.05).


CONCLUSIONS
Significantly inhibition of LDL oxidation and significantly reduction in TOS levels of group II after 2 months of ASA treatment shows that ASA treatment may contribute to the prevention of atherosclerosis, a beneficial effect which is dose and time dependent.
Kurban
Sevil
S
University of Selcuk, Meram Faculty of Medicine, Department of Biochemistry, Konya, Turkey. svlkrbn@yahoo.com
Mehmetoglu
Idris
I
D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D001241:Aspirin / Q000008:administration & dosage / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood*; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood
D000975:Antioxidants; D015415:Biomarkers; D005343:Fibrinolytic Agents; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D014451:Ubiquinone; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; C024989:coenzyme Q10; D001241:Aspirin