Validation of the calculation of the clearance rate constant (k(mono)) of [(11)C]acetate using parametric k(mono) image for myocardial oxidative metabolism.
BACKGROUND
The purpose of this study was to validate the calculation of myocardial oxidative metabolism rate using a parametric clearance rate constant (k(mono)) image.


METHODS
Fifteen subjects (seven volunteers, eight patients) were studied. Dynamic PET was acquired after intravenous injection of 700 MBq of [(11)C]acetate. The clearance rate constant of [(11)C]acetate (k(mono)) was calculated pixel by pixel to generate the parametric k(mono) image. The k(mono) values from this image and those calculated from the dynamic image were compared in the same regions of interest (ROIs).


RESULTS
Two different methods showed an excellent correlation except in the very low range. Regression equations were y=0.99x+0.0034 (r(2)=0.86, P<.001) and y=1.16x-0.0077 (r(2)=0.87, P<.001) in normal volunteer and patient groups, respectively, and y=1.07x-0.0019 (r(2)=0.87, P<.001) when combined.


CONCLUSIONS
Both methods exhibited similar values of k(mono). Parametric k(mono) image may result in better visual understanding of regional myocardial oxidative metabolism.
Hussain
Raihan
R
Biomedical Imaging Research Center, University of Fukui, Fukui, Japan. raihan_h@yahoo.com
Kudo
Takashi
T
Tsujikawa
Testuya
T
Kobayashi
Masato
M
Fujibayashi
Yasuhisa
Y
Okazawa
Hidehiko
H
D000085:Acetates / Q000493:pharmacokinetics*; D000328:Adult; D000368:Aged; D002244:Carbon / Q000493:pharmacokinetics*; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D000085:Acetates; D019275:Radiopharmaceuticals; C438206:carbon-11 acetate; D002244:Carbon; D010100:Oxygen