A method for correlating in vivo prostate magnetic resonance imaging and histopathology using individualized magnetic resonance-based molds.
A method for the design and rapid manufacture of a patient specific tissue slicing device based on in vivo images in order to facilitate the process of correlating the images with histopathology is presented. The method is applied to radical prostatectomy specimens where the customized mold is designed using magnetic resonance (MR) images of each patient obtained prior to surgery. In this case, the mold holds the prostate in place while a knife with a single blade or multiple blades is inserted in slots which are positioned to obtain tissue blocks corresponding to the slices in the MR images. The resulting histological specimens demonstrate good anatomical correlation with the MR images.
Shah
Vijay
V
Imaging Physics, SAIC Frederick, Inc., NCI-Frederick, Frederick, Maryland 20892, USA.
Pohida
Thomas
T
Turkbey
Baris
B
Mani
Haresh
H
Merino
Maria
M
Pinto
Peter A
PA
Choyke
Peter
P
Bernardo
Marcelino
M
D000818:Animals; D017076:Computer-Aided Design; D004285:Dogs; D004867:Equipment Design; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011467:Prostate / Q000473:pathology*; D013997:Time Factors