Patients with a history of hyperemesis gravidarum have similar symptoms during egg stimulation and develop ovarian hyperstimulation syndrome: case series.
OBJECTIVE
To investigate the symptoms and outcomes of ovarian stimulation in patients with a history of hyperemesis gravidarum.


METHODS
Retrospective case series.


METHODS
Research laboratory of a university hospital.


METHODS
Participants in an ongoing study on hyperemesis gravidarum that reported ovarian stimulation for gestational surrogacy.


METHODS
Review of medical records.


METHODS
Pregnancy history, symptoms, estradiol level and mature oocyte number in cases, and nausea and vomiting level reported in surrogate.


RESULTS
Three cases in their early thirties with a history of hyperemesis gravidarum presented with severe nausea and vomiting during ovarian stimulation and ovarian hyperstimulation syndrome. Gestational carriers reported normal nausea and vomiting of pregnancy.


CONCLUSIONS
This series provides lessons for in vitro fertilization for cases with a history of hyperemesis gravidarum and their gestational carriers as well as insight into the cause of hyperemesis gravidarum and its potential role in fertility. A link between hyperemesis gravidarum and an evolutionary advantage of increased fertility suggests a novel theory to explain the selection for nausea and vomiting in pregnancy.
Fejzo
Marlena S
MS
Department of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. mfejzo@mednet.ucla.edu
Romero
Roberto
R
Goodwin
T Murphy
TM
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D020022:Genetic Predisposition to Disease; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy; D009325:Nausea / Q000209:etiology; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology* / Q000503:physiopathology; D010062:Ovulation Induction / Q000009:adverse effects*; D010289:Parenteral Nutrition, Total; D011247:Pregnancy; D012720:Severity of Illness Index; D013533:Gestational Carriers; D014839:Vomiting / Q000209:etiology