title: Bioactive jatrophane diterpenes from Euphorbia guyoniana.
abstract: Chromatographic investigation of the methylenechloride/methanol extract of the aerial parts of Euphorbia guyoniana afforded two jatrophane diterpenes, designated guyonianins E and F, in addition to a known jatrophane diterpene. The structures of the compounds were determined by comprehensive NMR analyses, including DEPT, COSY, HMQC, HMBC, NOESY and HRMS. These compounds exhibited cytotoxicity against human embryonic kidney 293 (HEK293) cells with IC(50) values of 35-100 microM.
authors.affiliation: Chemistry of Medicinal Plants Department, National Research Center, Dokki, Cairo, Egypt.
authors.forename: Mohamed-Elamir F
authors.initials: ME
authors.lastname: Hegazy
authors.forename: Abou El-Hamd H
authors.initials: Ael-H
authors.lastname: Mohamed
authors.forename: Nobuwa
authors.initials: N
authors.lastname: Aoki
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Ikeuchi
authors.forename: Emi
authors.initials: E
authors.lastname: Ohta
authors.forename: Shinji
authors.initials: S
authors.lastname: Ohta
mesh_terms: D002460:Cell Line; D003603:Cytotoxins / Q000737:chemistry / Q000494:pharmacology*; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D003603:Cytotoxins; D004224:Diterpenes; D010936:Plant Extracts; C551326:guyonianin E; C551327:guyonianin F