Asymmetric total syntheses of (-)-renieramycin M and G and (-)-jorumycin using aziridine as a lynchpin.
By exploring the triple reactivity of two aziridines and double nucleophilicity of two aromatics, convergent and versatile syntheses of the above four natural products were developed.
Wu
Yan-Chao
YC
Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France.
Zhu
Jieping
J
D000818:Animals; D001388:Aziridines / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis* / Q000737:chemistry
D001388:Aziridines; D044005:Tetrahydroisoquinolines; C507297:jorumycin; C507294:renieramycin G; C482478:renieramycin M; C033132:aziridine