title: Peripheral arterial thrombosis with presence of anti-centromere antibodies and polycythemia vera.
abstract: Digital gangrene due to arterial thrombosis can occur due to a variety of causes. There have been reports of patients who have presented with digital gangrene with no known predisposing factors, but with positive anti-centromere antibodies (ACA). Despite that they did not have features suggestive of disorders like Scleroderma or CREST syndrome. We report a patient with digital gangrene, who was asymptomatic before this episode and was found to have both ACA positivity and Polycythemia Vera.
authors.affiliation: Internal Medicine Residency Program, St. Mary's Health Center, St. Louis, unnikrishnanpk@yahoo.com
authors.forename: Unnikrishnan
authors.initials: U
authors.lastname: Pillai
authors.forename: Jameel
authors.initials: J
authors.lastname: Muzaffar
authors.forename: Chitra
authors.initials: C
authors.lastname: Uppaluri
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D002503:Centromere / Q000276:immunology*; D005260:Female; D005385:Fingers / Q000098:blood supply*; D005734:Gangrene / Q000209:etiology; D006801:Humans; D011087:Polycythemia Vera / Q000150:complications* / Q000276:immunology*; D013927:Thrombosis / Q000150:complications*
chemical_list: D001323:Autoantibodies