title: Four new cytotoxic oligosaccharidic derivatives of 12-oleanene from Lysimachia heterogenea Klatt.
abstract: Cytotoxicity-guided phytochemical analysis on the extract of Lysimachia heterogenea Klatt led to the isolation of 3beta,16beta-12-oleanene-3,16,23,28-tetrol (1) and its four new oligosaccharidic derivatives heterogenosides A, B, C, and D (2-5). Their structural elucidation was mainly based on NMR and mass spectral data. The time course experimental results indicated that unlike the likely lysis activity of heterogenosides B-D, heterogenoside A showed a significantly time-dependent cytotoxicity.
authors.affiliation: Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. xahuang@163.net
authors.forename: Xin-an
authors.initials: XA
authors.lastname: Huang
authors.forename: Yong-ju
authors.initials: YJ
authors.lastname: Liang
authors.forename: Xiao-ling
authors.initials: XL
authors.lastname: Cai
authors.forename: Xiao-quan
authors.initials: XQ
authors.lastname: Feng
authors.forename: Chuan-hai
authors.initials: CH
authors.lastname: Zhang
authors.forename: Li-wu
authors.initials: LW
authors.lastname: Fu
authors.forename: Wen-di
authors.initials: WD
authors.lastname: Deng
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D029623:Primulaceae / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D013329:Structure-Activity Relationship
chemical_list: C546448:12-oleanene-3,16,23,28-tetrol; D000970:Antineoplastic Agents; D012503:Saponins; D009828:Oleanolic Acid