title: Update on the use of aromatase inhibitors in early-stage breast cancer.
abstract: Aromatase inhibitors are currently included in the 'optimal' management of early-stage breast cancer. Uncertainty remains, however, as to the most appropriate treatment strategy, particularly for newly diagnosed women as they seek to trade off the cost, toxicities and efficacy of the treatment options. Recent publications provide conflicting advice on the role of aromatase inhibitors in the treatment of postmenopausal patients with early-stage hormone receptor-positive breast cancer. This review provides updates on the clinical trials of aromatase inhibitors in early breast cancer and tries to provide practical clinical guidance on their optimal use.
authors.affiliation: Mount Vernon Cancer Centre, Rickmansworth, Northwood, Middlesex, HA6 2RN, UK. kesgeo@hotmail.com
authors.forename: Georgios
authors.initials: G
authors.lastname: Kesisis
authors.forename: Andreas
authors.initials: A
authors.lastname: Makris
authors.forename: David
authors.initials: D
authors.lastname: Miles
mesh_terms: D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D009367:Neoplasm Staging
chemical_list: D047072:Aromatase Inhibitors