title: THE EFFECT OF CARBON DIOXIDE TENSION ON TISSUE METABOLISM (RETINA).
abstract: The metabolism of rat retina was found to be sensitive to the concentration of the carbon dioxide-bicarbonate buffer system. Increasing the carbon dioxide from 1 per cent to 5 per cent at constant pH nearly doubled both respiration and glycolysis. Increasing the carbon dioxide at constant pH from 5 per cent to 20 per cent had no effect on glycolysis, but depressed the Q(O(O2) ) from 31 to 19. In a medium containing glucose and the 1 per cent carbon dioxide-bicarbonate buffer, the addition of succinate increased the Q(O(O2) ) from 12 to 26, without affecting glycolysis. In a medium containing glucose and phosphate, succinate had no significant effect.
authors.affiliation: Anesthesia Laboratory of the Harvard Medical School at the Massachusetts General Hospital, Boston.
authors.forename: F N
authors.initials: FN
authors.lastname: Craig
authors.forename: H K
authors.initials: HK
authors.lastname: Beecher