Renal function and genetic variation in dopamine D(1) receptor: is the case strong enough?
Polymorphisms in the genes involved in the dopaminergic system have been implicated in susceptibility to hypertension. A new study by Fung et al. takes a closer look at the association of genetic variants in the dopamine D(1) receptor gene (DRD1) with blood pressure and renal parameters. Although the study does not confirm an association with blood pressure, it suggests a new link between a common variant in the 5'-untranslated region of the DRD1 gene and low glomerular filtration rate.
Kiryluk
Krzysztof
K
Department of Medicine, Division of Nephrology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. kk473@columbia.edu
D020121:5' Untranslated Regions; D001794:Blood Pressure / Q000235:genetics; D004298:Dopamine / Q000235:genetics; D005787:Gene Frequency; D014644:Genetic Variation; D005919:Glomerular Filtration Rate / Q000235:genetics; D006801:Humans; D007677:Kidney Function Tests; D011110:Polymorphism, Genetic; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D017422:Sequence Analysis, DNA
D020121:5' Untranslated Regions; D017447:Receptors, Dopamine D1; D004298:Dopamine