Bioactive constituents of the stem bark of Mitrephora glabra.
Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three ent-kaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.
Li
Chen
C
Natural Products Laboratory, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, USA.
Lee
Dongho
D
Graf
Tyler N
TN
Phifer
Sharnelle S
SS
Nakanishi
Yuka
Y
Riswan
Soedarsono
S
Setyowati
Fransisca M
FM
Saribi
Achmad M
AM
Soejarto
Djaja D
DD
Farnsworth
Norman R
NR
Falkinham
Joseph O
JO
Kroll
David J
DJ
Kinghorn
A Douglas
AD
Wani
Mansukh C
MC
Oberlies
Nicholas H
NH
D029061:Annonaceae / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001060:Aporphines / Q000302:isolation & purification; D001234:Aspergillus niger / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007214:Indonesia; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D015394:Molecular Structure; D009161:Mycobacterium / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D053279:Polyynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects
D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; D004224:Diterpenes; D053279:Polyynes; C026980:liriodenine