Mechanisms of ubiquitin transfer by the anaphase-promoting complex.
The anaphase-promoting complex (APC) is a ubiquitin-protein ligase required for the completion of mitosis in all eukaryotes. Recent mechanistic studies reveal how this remarkable enzyme combines specificity in substrate binding with flexibility in ubiquitin transfer, thereby allowing the modification of multiple lysines on the substrate as well as specific lysines on ubiquitin itself.
Matyskiela
Mary E
ME
Department of Physiology, University of California, San Francisco, CA 94158, USA.
Rodrigo-Brenni
Monica C
MC
Morgan
David O
DO
D064173:Anaphase-Promoting Complex-Cyclosome; D055162:Biocatalysis; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D013379:Substrate Specificity; D025801:Ubiquitin / Q000737:chemistry / Q000378:metabolism*; D043743:Ubiquitin-Protein Ligase Complexes / Q000737:chemistry / Q000502:physiology*; D054875:Ubiquitination / Q000502:physiology*
D025801:Ubiquitin; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome