Eosinophil-mediated tissue inflammatory responses in helminth infection.
Eosinophilic leukocytes function in host protection against parasitic worms. In turn, helminthic parasites harbor specific molecules to evade or paralyze eosinophil-associated host immune responses; these molecules facilitate the migration and survival of parasitic helminths in vivo. This competition between eosinophil and worm leads to stable equilibria between them. An understanding of such dynamic host-eosinophil interactions will help us to uncover mechanisms of cross talk between host and parasite in helminth infection. In this review, we examine recent findings regarding the innate immune responses of eosinophils to helminthic parasites, and discuss the implications of these findings in terms of eosinophil-mediated tissue inflammation in helminth infection.
Shin
Myeong Heon
MH
Department of Environmental Medical Biology, and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul 120-752, Korea. myeong@yuhs.ac
Lee
Young Ah
YA
Min
Duk-Young
DY
D000818:Animals; D004804:Eosinophils / Q000276:immunology* / Q000469:parasitology; D006373:Helminthiasis / Q000276:immunology* / Q000469:parasitology*; D006376:Helminths / Q000276:immunology*; D006790:Host-Parasite Interactions; D006801:Humans