Intrathecal liposomal cytarabine in combination with temozolomide in low-grade oligoastrocytoma with leptomeningeal dissemination.
Leptomeningeal dissemination of low-grade gliomas is an uncommon event. A 43-year old male presented with dizziness, gait ataxia, and diplopia. A nonenhancing lesion in the right cerebellar peduncle was identified, subtotally resected, and diagnosed as a grade II astrocytoma. After one year a nodular spread in the brain and leptomeninges was diagnosed, so the patient started chemotherapy with temozolomide and liposomal cytarabine. Complete remission was achieved after 12 months of treatment and the patient is still free from the disease after a follow-up of 24 months. We suggest that this combination may be a valuable treatment option.
Passarin
Maria Grazia
MG
Division of Neurology, USSL 22, Via Ospedale 6, 37012 Bussolengo, Verona, Italy. mariagraziapassarin@hotmail.it
Moretto
Giuseppe
G
Musso
Anna Maria
AM
Ottaviani
Sarah
S
Masotto
Barbara
B
Ghimenton
Claudio
C
Iuzzolino
Paolo
P
Buffone
Ebba
E
Rudà
Roberta
R
Soffietti
Riccardo
R
Vattemi
Emanuela
E
Pedersini
Rebecca
R
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000150:complications / Q000188:drug therapy*; D003561:Cytarabine / Q000627:therapeutic use*; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007278:Injections, Spinal / Q000379:methods; D008081:Liposomes / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications / Q000188:drug therapy*; D009837:Oligodendroglioma / Q000150:complications / Q000188:drug therapy*; D000077204:Temozolomide
D000970:Antineoplastic Agents; D008081:Liposomes; D003561:Cytarabine; D003606:Dacarbazine; D000077204:Temozolomide