title: The transcription factor GATA-2 does not associate with angiographic coronary artery disease in the Ottawa Heart Genomics and Cleveland Clinic GeneBank Studies.
abstract: The transcription factor GATA2 was reported to associate with coronary artery disease (CAD) in the family-based Genecard sample (Connelly et al. in PLoS Genet 2:e139, 2006). We asked whether GATA2 associates with sporadic cases of CAD in the Ottawa Heart Genomics Study (OHGS) and Cleveland Clinic (CC) populations. We genotyped the lead single nucleotide polymorphism (SNP) from Genecard, rs2713604 which is located in intron 5-6 of GATA2 in 600 CAD cases and 625 controls, as well as a tag SNP rs1573949 (r (2) = 0.87 in Caucasians of European ancestry in Utah from HapMap) in 1,136 cases and 1,162 controls in the OHGS1 population. A further 1,838 CAD cases and 913 controls derived from an independent sample combining genotypes from CC and OHGS2 populations were genotyped for rs1573949. Neither of the genotyped SNPs associates with CAD in the OHGS1 or CC/OHGS2 populations. Our data suggest that GATA2 does not contribute to the development of angiographic CAD among sporadic cases.
authors.affiliation: The John & Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Canada.
authors.forename: Sonny
authors.initials: S
authors.lastname: Dandona
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Meng
authors.initials: M
authors.lastname: Fan
authors.forename: Md Afaque
authors.initials: MA
authors.lastname: Alam
authors.forename: Olivia
authors.initials: O
authors.lastname: Assogba
authors.forename: Melanie
authors.initials: M
authors.lastname: Belanger
authors.forename: Kathryn
authors.initials: K
authors.lastname: Williams
authors.forename: George A
authors.initials: GA
authors.lastname: Wells
authors.forename: W H Wilson
authors.initials: WH
authors.lastname: Tang
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Ellis
authors.forename: Stanley L
authors.initials: SL
authors.lastname: Hazen
authors.forename: Ruth
authors.initials: R
authors.lastname: McPherson
authors.forename: Robert
authors.initials: R
authors.lastname: Roberts
authors.forename: Alexandre F R
authors.initials: AF
authors.lastname: Stewart
mesh_terms: D000328:Adult; D000368:Aged; D002170:Canada; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000235:genetics*; D005260:Female; D050989:GATA2 Transcription Factor / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D009820:Ohio; D020641:Polymorphism, Single Nucleotide
chemical_list: D050989:GATA2 Transcription Factor; C494711:GATA2 protein, human