Micro-RNAs: viral genome and robustness of gene expression in the host.
For comparing RNA rings or hairpins with reference or random ring sequences, circular versions of distances and distributions like those of Hamming and Gumbel are needed. We define these circular versions and we apply these new tools to the comparison of RNA relics (such as micro-RNAs and tRNAs) with viral genomes that have coevolved with them. Then we show how robust are the regulation networks incorporating in their boundary micro-RNAs as sources or new feedback loops involving ubiquitous proteins like p53 (which is a micro-RNA transcription factor) or oligopeptides regulating protein translation. Eventually, we propose a new coevolution game between viral and host genomes.
Demongeot
Jacques
J
Faculty of Medicine, University Joseph Fourier, Grenoble, TIMC-IMAG UMR UJF/CNRS 5525, 38700 La Tronche, France. jacques.demongeot@imag.fr
Drouet
Emmanuel
E
Elena
Adrien
A
Moreira
Andrès
A
Rechoum
Yassine
Y
Sené
Sylvain
S
D015967:Gene Expression Regulation, Viral / Q000235:genetics*; D016679:Genome, Viral / Q000235:genetics*; D054884:Host-Pathogen Interactions / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009690:Nucleic Acid Conformation
D035683:MicroRNAs