Gene expression profiling in brain regions of a rat model displaying schizophrenia-related features.
Animal models allow insights into complex neurodevelopmental disorders. Apomorphine-susceptible rats (so-called APO-SUS rats) provide a model that displays a complex phenotype with schizophrenia-related features and together with its phenotypic counterpart (APO-UNSUS rats) has been independently generated twice (original and replicate rat lines). To understand the molecular basis underlying this phenotype, we here performed mRNA expression profiling in various APO-SUS and APO-UNSUS rat brain regions. The expression of only the previously reported Aph-1b and the newly discovered KCnIP1 (a member of the potassium channel-interacting protein family that is known to modulate neuronal channel activity) was significantly different in the APO-SUS and APO-UNSUS rats from both the original and replicate rat lines. Thus, KCnIP1 may constitute a novel candidate gene playing a role in the complex phenotype of the APO-SUS/APO-UNSUS rat model and further studies on this gene are warranted.
Van Schijndel
Jessica E
JE
Department of Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour & Nijmegen Centre for Molecular Life Sciences, Faculty of Science, Radboud University Nijmegen, RT282, Geert Grooteplein Zuid 28, 6525 GA, Nijmegen, The Netherlands.
Van Zweeden
Martine
M
Van Loo
Karen M J
KM
Martens
Gerard J M
GJ
D000818:Animals; D001058:Apomorphine; D001921:Brain / Q000378:metabolism*; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D051605:Kv Channel-Interacting Proteins / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D046228:Microarray Analysis; D010641:Phenotype; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012559:Schizophrenia / Q000139:chemically induced / Q000235:genetics* / Q000378:metabolism*; D013045:Species Specificity
C508903:Aph-1 protein, rat; C496757:Kcnip1 protein, rat; D051605:Kv Channel-Interacting Proteins; D008565:Membrane Proteins; D012333:RNA, Messenger; D001058:Apomorphine