Harzianic acid, an antifungal and plant growth promoting metabolite from Trichoderma harzianum.
A Trichoderma harzianum strain, isolated from composted hardwood bark in Western Australia, was found to produce a metabolite with antifungal and plant growth promoting activity. The structure and absolute configuration of the fungal compound, harzianic acid (1), were determined by X-ray diffraction studies. Harzianic acid showed antibiotic activity against Pythium irregulare, Sclerotinia sclerotiorum, and Rhizoctonia solani. A plant growth promotion effect was observed at low concentrations of 1.
Vinale
Francesco
F
School of Earth and Geographical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, 6009. frvinale@unina.it
Flematti
Gavin
G
Sivasithamparam
Krishnapillai
K
Lorito
Matteo
M
Marra
Roberta
R
Skelton
Brian W
BW
Ghisalberti
Emilio L
EL
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects; D018360:Crystallography, X-Ray; D006885:Hydroxybutyrates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010937:Plant Growth Regulators / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011775:Pythium / Q000187:drug effects; D012232:Rhizoctonia / Q000187:drug effects*; D014242:Trichoderma / Q000737:chemistry*; D014904:Western Australia
D000935:Antifungal Agents; D006885:Hydroxybutyrates; D010937:Plant Growth Regulators; D011758:Pyrroles; C088506:harzianic acid