title: Congenital uterine anomalies affecting reproduction.
abstract: The following review seeks to summarise the current data regarding reproductive outcomes associated with congenital uterine anomalies. Such malformations originate from adverse embryologic events ranging from agenesis to lateral and vertical fusion defects. Associated renal anomalies are common both for the symmetric and asymmetric malformations. While fertility is minimally impacted upon by müllerian anomalies in most cases, such malformations have historically been associated with poor obstetric outcomes such as recurrent miscarriage, second trimester loss, preterm delivery, malpresentation and intrauterine foetal demise (IUFD). The following review delineates the existing literature regarding such outcomes and indicates therapies, where applicable, to optimise the care of such patients.
authors.affiliation: Department of Obstetrics and Gynecology, Brigham Women's Hospital, Boston, MA, USA.
authors.forename: David E
authors.initials: DE
authors.lastname: Reichman
authors.forename: Marc R
authors.initials: MR
authors.lastname: Laufer
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology; D000013:Congenital Abnormalities / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D011247:Pregnancy; D011256:Pregnancy Outcome; D014599:Uterus / Q000002:abnormalities* / Q000196:embryology