Topiramate overdose: a case report of a patient with extremely high topiramate serum concentrations and nonconvulsive status epilepticus.
We report the case of a 21-year-old man with idiopathic generalized epilepsy who ingested about 8,000 mg of topiramate (TPM) in a suicide attempt. On admission to the hospital he had a nonconvulsive status epilepticus and received 4 mg lorazepam i.v. He recovered rapidly despite an initial TPM concentration of 144.6 microg/ml. To our knowledge, this is the first report of a patient who survived such a high TPM concentration. The case indicates that nonconvulsive status epilepticus could be a manifestation of TPM intoxication.
Brandt
Christian
C
Bethel Epilepsy Centre, Department of General Epileptology, Bielefeld, Germany.
Elsner
Heike
H
Füratsch
Nora
N
Hoppe
Matthias
M
Nieder
Esther
E
Rambeck
Bernhard
B
Ebner
Alois
A
May
Theodor W
TW
D062787:Drug Overdose; D005632:Fructose / Q000031:analogs & derivatives* / Q000097:blood / Q000506:poisoning; D006801:Humans; D008297:Male; D013226:Status Epilepticus / Q000097:blood* / Q000139:chemically induced / Q000175:diagnosis; D013406:Suicide, Attempted; D000077236:Topiramate; D055815:Young Adult
D000077236:Topiramate; D005632:Fructose