[Dry plant extracts in the prescription of dental hydrogels with Carbopol 971P].
The study assumption was to work out a prescription for dental anti-inflammatory hydrogel on Carbopol 971P base. Dry plant extracts (sage, horsetail) and nonsteroidal anti-inflammatory drug (sodium ibuprofen) were introduced into the prescription of a model hydrogel. The aim of the study was to estimate pharmaceutical availability of the applied therapeutic agents and to test their effect on physicochemical properties of the produced form of a drug. The physicochemical parameters of the produced preparation were tested. Viscosity tests were performed using cone-plate digital rheometer. Extensometric method was used to test extensibility. pH measurements were performed by direct immersing the electrode connected with pH-meter into the hydrogel samples of uniform mass. Pharmaceutical availability of therapeutic agents contained in hydrogel (active components of plant extracts, sodium ibuprofen) was estimated. The rate of the process of mass exchange was tested by spectrophotometric method determining the quantity of therapeutic agents diffusing into acceptor fluid at the same time intervals. Sodium ibuprofen is better released from the hydrogel containing horsetail extract (815.5 c.u.) than from the hydrogel of parallel prescription containing sage extract (640.8 c.u.). Hydrogels containing dry extract from horsetail have greater extensibility and lower structural viscosity as well as the value of yield stress than equivalent hydrogels containing sage extract. Introduction of sodium ibuprofen into the prescription of hydrogels with plant extracts modifies rheological parameters (greater extensibility, lower viscosity of the preparation). The tests of the kinetics of therapeutic agents release demonstrated that the presence of sodium ibuprofen in the prescription of hydrogels exerts an influence on the decrease of the effectiveness of the release of active substances contained in these extracts.
Kołodziejska
Justyna
J
Katedra Farmacji Stosowanej, Uniwersytet Medyczny w Łodzi. jkolodziejska0730@wp.pl
Berner-Strzelczyk
Aneta
A
Piechota-Urbańska
Magdalena
M
D000179:Acrylates / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D020829:Equisetum; D020100:Hydrogels / Q000737:chemistry* / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000737:chemistry* / Q000493:pharmacokinetics; D053210:Pharmaceutical Preparations, Dental / Q000737:chemistry* / Q000493:pharmacokinetics; D010936:Plant Extracts / Q000737:chemistry* / Q000493:pharmacokinetics; D012212:Rheology; D027543:Salvia officinalis
D000179:Acrylates; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D020100:Hydrogels; D053210:Pharmaceutical Preparations, Dental; D010936:Plant Extracts; C492577:carbopol 971P; D007052:Ibuprofen