title: Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans.
abstract: BACKGROUND
  Prostate cancer (Pca) is a common malignancy that disproportionately affects African American men (AA). Recently there have been several genome-wide association studies (GWAS) implicating new prostate cancer risk loci along chromosomes 2, 3, 6, 7, 8, 10, 11, 12, 17, 19, and X in populations of European ancestry. Given the higher incidence and mortality for AAs, and differences in allele frequencies and haplotype structures between African and European descent populations, it is important to assess the impact of these candidate risk loci in AAs.
  
  
  METHODS
  Here we evaluated 20 single nucleotide polymorphisms (SNPs) associated with prostate cancer risk in recent GWAS studies, in AA prostate cancer cases and controls.
  
  
  RESULTS
  We replicated five of the SNPs in our AA population, rs10896449 on 11q13.2 (P = 0.009), rs2735839 on 19q33.33 region, (P = 0.04), rs443076 on chromosome 17q12 (P = 0.008), rs5945572 on Xp11.22 (P = 0.05), as well as the rare variant specific to west African ancestry, bd11934905 in region 2 of 8q24 (P = 1 x 10(-4)).
  
  
  CONCLUSIONS
  While we were able to replicate a few of the previous GWAS SNPs, we were not able to confirm the vast majority of these associations in our AA population. This finding further supports the need to perform GWAS and additional fine mapping in AAs to locate additional susceptibility loci.
authors.affiliation: Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Stanley
authors.initials: S
authors.lastname: Hooker
authors.forename: Wenndy
authors.initials: W
authors.lastname: Hernandez
authors.forename: Hankui
authors.initials: H
authors.lastname: Chen
authors.forename: Christiane
authors.initials: C
authors.lastname: Robbins
authors.forename: Jada Benn
authors.initials: JB
authors.lastname: Torres
authors.forename: Chiledum
authors.initials: C
authors.lastname: Ahaghotu
authors.forename: John
authors.initials: J
authors.lastname: Carpten
authors.forename: Rick A
authors.initials: RA
authors.lastname: Kittles
mesh_terms: D001741:Black or African American / Q000235:genetics*; D000368:Aged; D016022:Case-Control Studies; D002874:Chromosome Mapping; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000235:genetics*