A novel heterocyclic scaffold formed by ring expansion of a cyclic sulfone to sulfonamides.
A novel heterocyclic scaffold with a peptidomimetic backbone structure has been synthesized. The scaffold is formed by insertion of primary amines into a cyclic sulfone to give the corresponding ring-expanded sulfonamides. By varying the amine component, a series of potentially biologically interesting compounds has been synthesized.
Sellstedt
Magnus
M
Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden.
Almqvist
Fredrik
F
D000588:Amines / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry*
D000588:Amines; D013449:Sulfonamides; D013450:Sulfones