title: Evaluation of anti-wrinkle effects of a novel cosmetic containing retinol using the guideline of the Japan Cosmetic Industry Association.
abstract: Retinol is known to be effective in the treatment of sallowness, wrinkling, red blotchiness and hyperpigmented spots in aging skin. In this study, we have evaluated the anti-wrinkle effects of a new cosmetic containing retinol. An open study was performed in 30 healthy Japanese women who had wrinkles at the corners of the eyes. The tested lotion, Retin-OX+ (RoC SA, Colombes, France), was applied on wrinkles of one side of the face for 8 weeks, and not on the other site as a control. Anti-wrinkle effects were evaluated by two methods: (i) doctors' observation and photos based on the guideline of the Japan Cosmetic Industry Association; and (ii) the Robo Skin Analyzer. This lotion showed marked and moderate improvement in 34% of the subjects with a significant difference as compared with the control sites (P < 0.05). Moreover, the length and area decreased in the applied site more than the control site with a significant difference (P < 0.01). All the patients completed the study without significant adverse reactions. The tested lotion was well tolerated and may be an optional preparation for the treatment of wrinkles at the corner of the eyes.
authors.affiliation: Department of Dermatology, Kinki University School of Medicine, Osaka-Sayama City, Osaka, Japan. kawada@med.kindai.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Kawada
authors.forename: Natsuko
authors.initials: N
authors.lastname: Konishi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Momma
authors.forename: Naoki
authors.initials: N
authors.lastname: Oiso
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kawara
mesh_terms: D000287:Administration, Topical; D000328:Adult; D001505:Beauty Culture / Q000592:standards*; D003257:Consumer Product Safety; D003358:Cosmetics / Q000008:administration & dosage*; D004643:Emollients / Q000008:administration & dosage; D004954:Esthetics; D005260:Female; D017408:Guidelines as Topic; D006801:Humans; D007564:Japan; D008875:Middle Aged; D017060:Patient Satisfaction; D012016:Reference Values; D015595:Skin Aging / Q000187:drug effects* / Q000502:physiology; D016896:Treatment Outcome; D014801:Vitamin A / Q000008:administration & dosage*
chemical_list: D003358:Cosmetics; D004643:Emollients; D014801:Vitamin A