Aggressive undifferentiated colon carcinoma producing granulocyte-colony stimulating factor: report of a case.
We report a rare case of granulocyte-colony stimulating factor (G-CSF)-producing undifferentiated carcinoma of the ascending colon. A 52-year-old Japanese man presented with a rapidly growing, aggressive abdominal tumor, and severe leukocytosis (63 000/mm(3)). The serum level of G-CSF was remarkably elevated to 640 pg/ml (normal, <18.1 pg/ml). The patient underwent palliative cytoreductive surgery for ascending colon carcinoma with lymph node and liver metastases. Histological examination revealed an undifferentiated carcinoma of the ascending colon. The tumor cells were positive for G-CSF on immunohistochemical staining. The leukocyte counts and G-CSF level decreased after surgery. Thus, we diagnosed G-CSF-producing colon carcinoma. His general condition deteriorated rapidly and he died of residual tumor growth on postoperative day 24.
Matsuda
Akihisa
A
Department of Surgery, Nippon Medical School Tama-Nagayama Hospital, Tama, Tokyo 206-8512, Japan.
Sasajima
Koji
K
Matsutani
Takeshi
T
Maruyama
Hiroshi
H
Miyamoto
Masayuki
M
Yokoyama
Tadashi
T
Suzuki
Seiji
S
Suzuki
Hideyuki
H
Tajiri
Takashi
T
D014408:Biomarkers, Tumor / Q000378:metabolism; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D003082:Colectomy / Q000379:methods; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D003113:Colonoscopy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005500:Follow-Up Studies; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged
D014408:Biomarkers, Tumor; D016179:Granulocyte Colony-Stimulating Factor