title: Investigation of the association between CALCRL polymorphisms and primary angle closure glaucoma.
abstract: OBJECTIVE
  To determine whether the polymorphisms of calcitonin receptor-like receptor gene (CALCRL) are associated with primary angle closure glaucoma (PACG) in a southern Chinese population.
  
  
  METHODS
  A total of 207 individuals with acute and chronic PACG and 205 ethnically matched controls were recruited in the current study. A tag-single nucleotide polymorphism approach was used to investigate this gene. Alleles were determined by PCR restriction fragment length polymorphism.
  
  
  RESULTS
  The results show a nominal association between rs1157699 and acute PACG (uncorrected p=0.024 and 0.028 for alleles and genotypes, respectively). Haplotype T(rs840617)C(rs6759535)T(rs1157699) frequency is significantly higher in acute PACG patients than in controls (corrected p=0.012), whereas haplotype T(rs840617)C(rs6759535)C(rs1157699) frequency is significantly lower in acute PACG patients compared with controls (corrected p=0.02). However, no significant difference was detected between chronic PACG and CALCRL tag single nucleotide polymorphisms.
  
  
  CONCLUSIONS
  The study suggests a possible role of CALCRL in the pathogenesis of acute PACG but not chronic PACG. A replication of this study with a larger sample size as well as on different populations will be helpful in confirming this finding.
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, PR China.
authors.forename: Dan
authors.initials: D
authors.lastname: Cao
authors.forename: Xing
authors.initials: X
authors.lastname: Liu
authors.forename: Xiangming
authors.initials: X
authors.lastname: Guo
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Cong
authors.forename: Jingjing
authors.initials: J
authors.lastname: Huang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Mao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D058286:Calcitonin Receptor-Like Protein; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D015812:Glaucoma, Angle-Closure / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018003:Receptors, Calcitonin / Q000235:genetics*
chemical_list: C545578:CALCRL protein, human; D058286:Calcitonin Receptor-Like Protein; D005819:Genetic Markers; D018003:Receptors, Calcitonin