title: Effect of recombinant basic fibroblast growth factor on reimplanted teeth in beagle dogs.
abstract: OBJECTIVE
  This study assessed the effect of recombinant fibroblast growth factor (FGF-2) on reimplanted teeth.
  
  
  METHODS
  Premolars were reimplanted in dogs. Roots on the left side of the mandible were treated with FGF-2, whereas roots on right side served as controls. At 2, 4, or 8 weeks after treatment, animals were humanely killed and specimens collected and processed for histopathologic examination.
  
  
  RESULTS
  After 2 weeks, proliferating cell nuclear antigen-positive cell ratios in the experimental group were significantly greater than those in the control group (P < .01). After 4 and 8 weeks, the experimental group showed formation of new cementum. Moreover, incidence of replacement resorption in the experimental group was significantly lower than that in the control group (P < .01).
  
  
  CONCLUSIONS
  The results indicate that FGF-2 promotes formation of new periodontal ligament and prevents ankylosis and root resorption following reimplantation of teeth.
authors.affiliation: Resident, Department of Periodontics, Tokyo Dental College, Chiba, Japan. seshimaf@tdc.ac.jp
authors.forename: Fumi
authors.initials: F
authors.lastname: Seshima
authors.forename: Mikio
authors.initials: M
authors.lastname: Ota
authors.forename: Takashi
authors.initials: T
authors.lastname: Kinumatsu
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Shibukawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamada
mesh_terms: D000818:Animals; D003739:Dental Cementum / Q000187:drug effects / Q000502:physiology; D004285:Dogs; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D006133:Growth Substances / Q000494:pharmacology*; D007124:Immunoenzyme Techniques; D010513:Periodontal Ligament / Q000187:drug effects / Q000502:physiology; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis / Q000096:biosynthesis; D011994:Recombinant Proteins / Q000494:pharmacology; D012038:Regeneration / Q000187:drug effects*; D012391:Root Resorption / Q000517:prevention & control; D020254:Tooth Ankylosis / Q000517:prevention & control; D014090:Tooth Replantation
chemical_list: D006133:Growth Substances; D018809:Proliferating Cell Nuclear Antigen; D011994:Recombinant Proteins; D016222:Fibroblast Growth Factor 2