[Progress of research in osteoarthritis. The anti-inflammatory effects of intra-articular injected statin on experimental osteoarthritis].
Statins have been shown to have a wide range of anti-inflammatory effects on cells and tissues involved in inflammation that are unrelated to their lipid-lowering abilities. In the progression of osteoarthritis (OA), mediators of inflammation from synovial tissue and cartilage play important roles in initiating or amplifying cartilage degradation in OA. Therefore, we examined the therapeutic efficacy of intra-articularly injected statin in rabbit OA. Intra-articular injections of statin during OA development reduced the infiltration of inflammatory cells and the expression of matrix-degrading enzymes, thus limiting cartilage degradation. Intra-articular injections of statin can be promising as a disease-modifying therapy for human OA.
Akasaki
Yukio
Y
Department of Orthopaedic Surgery, Kyushu University.
Matsuda
Shuichi
S
Iwamoto
Yukihide
Y
D000818:Animals; D000893:Anti-Inflammatory Agents; D018932:Chemokine CCL2 / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology; D018836:Inflammation Mediators / Q000378:metabolism; D007269:Injections, Intra-Arterial; D053583:Interleukin-1beta / Q000037:antagonists & inhibitors; D019278:Matrix Metalloproteinase 3 / Q000378:metabolism; D010003:Osteoarthritis / Q000188:drug therapy* / Q000209:etiology; D011817:Rabbits
D000893:Anti-Inflammatory Agents; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D018836:Inflammation Mediators; D053583:Interleukin-1beta; D019278:Matrix Metalloproteinase 3