title: Hepato-biliary late effects in survivors of childhood and adolescent cancer: a report from the Children's Oncology Group.
abstract: Curative therapy for childhood and adolescent cancer translates to 1 in 640 young adults being a survivor of cancer. Although acute hepato-biliary toxicity occurs commonly during pediatric cancer therapy, the impact of antineoplastic therapy on long-term liver health in childhood/adolescent cancer survivors is unknown. This article reviews the medical literature on late liver dysfunction following treatment for childhood/adolescent cancer. We also outline the Children's Oncology Group (COG) guidelines for screening and follow-up of hepato-biliary sequelae. As the population of survivors grow and age, vigilance for risks to hepatic health needs to continue based on specific exposures during curative cancer therapy.
authors.affiliation: Department of Pediatrics, Wake Forest University, Winston-Salem, NC27157, USA. scastell@wfubmc.edu
authors.forename: Sharon
authors.initials: S
authors.lastname: Castellino
authors.forename: Andrew
authors.initials: A
authors.lastname: Muir
authors.forename: Ami
authors.initials: A
authors.lastname: Shah
authors.forename: Sheila
authors.initials: S
authors.lastname: Shope
authors.forename: Kevin
authors.initials: K
authors.lastname: McMullen
authors.forename: Kathy
authors.initials: K
authors.lastname: Ruble
authors.forename: Ashley
authors.initials: A
authors.lastname: Barber
authors.forename: Andrew
authors.initials: A
authors.lastname: Davidoff
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Hudson
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects; D001649:Bile Duct Diseases / Q000209:etiology / Q000517:prevention & control*; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000209:etiology / Q000517:prevention & control; D002648:Child; D003266:Continuity of Patient Care; D006525:Hepatitis, Viral, Human / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008107:Liver Diseases / Q000209:etiology / Q000517:prevention & control*; D008403:Mass Screening / Q000379:methods; D009369:Neoplasms / Q000150:complications / Q000628:therapy*; D017410:Practice Guidelines as Topic; D011878:Radiotherapy / Q000009:adverse effects; D033581:Stem Cell Transplantation / Q000009:adverse effects; D017741:Survivors; D065227:Transfusion Reaction
chemical_list: D000970:Antineoplastic Agents