Abdominal aortitis after use of granulocyte colony-stimulating factor.
Granulocyte colony-stimulating factor (G-CSF) is a recombinant human glycoprotein that promotes proliferation and differentiation of granulocytic-committed progenitors. It is commonly used to treat neutropenia and is generally well tolerated. Occurrences of rare but serious adverse events in association with the use of G-CSF have been described. We report the case of a 54-year-old male with squamous cell carcinoma of the lung who developed abdominal aortitis following the use of G-CSF. Other possible aetiological conditions were excluded based on laboratory and radiological evaluations. To our knowledge, this represents the second case report demonstrating an association between aortitis and the use of G-CSF.
Adiga
Giridhar U
GU
Department of Oncology, Montefiore Medical Center North Division, New York Medical College, Bronx, NY 10466, USA.
Elkadi
Dahlia
D
Malik
Sandeep K
SK
Fitzpatrick
Jill D
JD
Madajewicz
Stefan
S
D001025:Aortitis / Q000139:chemically induced*; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy / Q000209:etiology
D016179:Granulocyte Colony-Stimulating Factor