title: Association of G1057D variant of insulin receptor substrate-2 with endometriosis.
abstract: OBJECTIVE
  To investigate whether the insulin receptor substrate (IRS)-2 G1057D polymorphism is associated with the risk of endometriosis, and to evaluate potential correlation of IRS2 gene polymorphism with the stages of endometriosis.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Gynecology clinics in university hospital.
  
  
  METHODS
  Women with (n = 135) or without (n = 135) endometriosis. Afterward, the women with endometriosis were divided into two groups according to the stage: group 1 included 63 women in stages I-II, and group 2 included 72 women in stages III-IV.
  
  
  METHODS
  Genotyping by polymerase chain reaction-based restriction fragment-length polymorphism method.
  
  
  METHODS
  Genotype distribution of the G1057D polymorphism in the IRS2 gene.
  
  
  RESULTS
  The genotype distribution of the IRS2 G1057D polymorphism in the endometriosis group was significantly different from that of the control group (GG/GD/DD rates were 43.0%/39.3%/17.7% and 55.6%/36.3%/8.1% for the endometriosis and control groups, respectively). Further subgroup analyses according to the stage of endometriosis also revealed a positive association between the IRS2 DD genotype expression and stage III-IV endometriosis patients in the population studied.
  
  
  CONCLUSIONS
  These results suggest that the IRS2 G1057D polymorphism may be associated with an increased risk for endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, University of Mersin School of Medicine, Mersin, Turkey. filizcayan@yahoo.com
authors.forename: Filiz
authors.initials: F
authors.lastname: Cayan
authors.forename: Devrim
authors.initials: D
authors.lastname: Ertunç
authors.forename: Nurcan
authors.initials: N
authors.lastname: Aras-Ateş
authors.forename: Lokman
authors.initials: L
authors.lastname: Ayaz
authors.forename: Esen
authors.initials: E
authors.lastname: Akbay
authors.forename: Sevim
authors.initials: S
authors.lastname: Karakaş
authors.forename: Ozgür
authors.initials: O
authors.lastname: Coban
authors.forename: Saffet
authors.initials: S
authors.lastname: Dilek
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D055504:Insulin Receptor Substrate Proteins / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D012720:Severity of Illness Index; D014591:Uterine Diseases / Q000235:genetics*
chemical_list: D055504:Insulin Receptor Substrate Proteins