title: Autoimmune polyglandular syndrome type 2 with myasthenia gravis crisis.
abstract: We describe a rare case of autoimmune polyglandular syndrome type 2 initially presenting as Addison disease and autoimmune thyroid disease, with subsequent development of autoimmune hepatitis and myasthenia gravis (MG) crisis in a Japanese woman. MG improved with oral prednisolone followed by plasmapheresis for immunoadsorption; thymectomy was not performed. Conventional treatment for MG was effective and safe in this case, in which there was positivity for human leukocyte antigen A23, B52, B62, DR11, and DR15.
authors.affiliation: Division of Neurology, and daggerDepartment of Internal Medicine, Division of Diabetes, Toho University Ohashi Medical Center, Tokyo, Japan. d500372@oha.toho-u.ac.jp
authors.forename: Shingo
authors.initials: S
authors.lastname: Konno
authors.forename: Takamasa
authors.initials: T
authors.lastname: Ichijo
authors.forename: Mayumi
authors.initials: M
authors.lastname: Murata
authors.forename: Takahiro
authors.initials: T
authors.lastname: Toda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakazora
authors.forename: Nobuatsu
authors.initials: N
authors.lastname: Nomoto
authors.forename: Hideki
authors.initials: H
authors.lastname: Sugimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nemoto
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Kurihara
authors.forename: Nobuo
authors.initials: N
authors.lastname: Wakata
authors.forename: Toshiki
authors.initials: T
authors.lastname: Fujioka
mesh_terms: D000368:Aged; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D009157:Myasthenia Gravis / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D010956:Plasmapheresis / Q000379:methods; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D011239:Prednisolone / Q000627:therapeutic use; D013934:Thymectomy / Q000379:methods
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone