title: Thermodynamic optimisation in drug discovery: a case study using carbonic anhydrase inhibitors.
authors.affiliation: Pfizer Global Research & Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NU., UK. Andrew.d.scott@pfizer.com
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Scott
authors.forename: Chris
authors.initials: C
authors.lastname: Phillips
authors.forename: Alexander
authors.initials: A
authors.lastname: Alex
authors.forename: Maria
authors.initials: M
authors.lastname: Flocco
authors.forename: Andrew
authors.initials: A
authors.lastname: Bent
authors.forename: Amy
authors.initials: A
authors.lastname: Randall
authors.forename: Ronan
authors.initials: R
authors.lastname: O'Brien
authors.forename: Luminita
authors.initials: L
authors.lastname: Damian
authors.forename: Lyn H
authors.initials: LH
authors.lastname: Jones
mesh_terms: D000818:Animals; D001554:Benzene / Q000737:chemistry / Q000494:pharmacology; D002151:Calorimetry; D024402:Carbonic Anhydrase II / Q000378:metabolism*; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D002417:Cattle; D018360:Crystallography, X-Ray; D055808:Drug Discovery; D006801:Humans; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology; D013816:Thermodynamics; D017186:Titrimetry
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D012710:Serum Albumin, Bovine; D024402:Carbonic Anhydrase II; D001554:Benzene