title: Synthesis of tetrahydropyrans from propargyl alcohols and 1,1-cyclopropanediesters: a one-pot ring-opening/Conia-ene protocol.
abstract: Lewis acid catalyzed ring opening of 1,1-cyclopropanediesters by the hydroxyl group of a propargyl alcohol sets up a subsequent Conia-ene cyclization to afford substituted tetrahydropyrans in a one-pot, high-yielding procedure.
authors.affiliation: Department of Chemistry, The University of Western Ontario, London, Ontario, Canada N6A 5B7.
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Leduc
authors.forename: Terry P
authors.initials: TP
authors.lastname: Lebold
authors.forename: Michael A
authors.initials: MA
authors.lastname: Kerr
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D020005:Propanols / Q000737:chemistry*; D011714:Pyrans / Q000138:chemical synthesis*
chemical_list: D000480:Alkynes; D020005:Propanols; D011714:Pyrans; C028255:propargyl alcohol