title: Substance P and NK-1R expression in oral precancerous epithelium.
abstract: The objectives of this study were to investigate the presence and distribution of substance P and neurokinin 1 receptor in oral premalignant epithelium and their relation with the presence of dysplasia, and to analyze whether the expression of substance P can be considered an early oncogenic event in oral carcinogenesis. substance P and neurokinin 1 receptor expression was immunohistochemically studied in 83 oral carcinomas and adjacent non-tumor epithelia. The presence and degree of epithelial dysplasia was assessed according to WHO criteria. The nuclear, cytoplasmic, and membrane expression of substance P and the cytoplasmic and membrane expression of neurokinin 1 receptor were assessed in tumor and adjacent non-tumor epithelium. Nuclear and cytoplasmic expression of substance P in non-tumor epithelium was significantly associated with the presence of epithelial dysplasia (p<0.001) and carcinoma in situ (p=0.021). Nuclear, cytoplasmic, and membrane expressions of substance P in non-tumor epithelium were significantly (p<0.001) associated with its expression in the corresponding tumor. These findings suggest that substance P plays a role in early oral carcinogenesis by promoting the proliferation and growth of premalignant fields.
authors.affiliation: Oral Medicine Department, School of Dentistry, University of Granada, Paseo de Cartuja s/n, Granada, Spain. magonzal@ugr.es
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Gonzalez-Moles
authors.forename: S
authors.initials: S
authors.lastname: Brener
authors.forename: I
authors.initials: I
authors.lastname: Ruiz-Avila
authors.forename: J A
authors.initials: JA
authors.lastname: Gil-Montoya
authors.forename: D
authors.initials: D
authors.lastname: Tostes
authors.forename: M
authors.initials: M
authors.lastname: Bravo
authors.forename: F
authors.initials: F
authors.lastname: Esteban
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D049109:Cell Proliferation; D004848:Epithelium / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000378:metabolism*; D011230:Precancerous Conditions / Q000378:metabolism*; D018040:Receptors, Neurokinin-1 / Q000096:biosynthesis*; D013373:Substance P / Q000096:biosynthesis*
chemical_list: D018040:Receptors, Neurokinin-1; D013373:Substance P