title: Total synthesis of (+/-)-cordypyridones A and B and related epimers.
abstract: Efficient racemic synthesis of two antibacterial and antimalarial natural products, cordypyridones A and B, was achieved from inexpensive, commercially available starting materials in an overall yield of 15% (8% and 7%, respectively). This convergent synthesis utilizes a key coupling step of two fragments and the subsequent functional group transformations lead to the target compounds and their 8-epi-analogues.
authors.affiliation: Institute of Chemical and Engineering Sciences, 1 Pesek Road, Jurong Island, Singapore, 627833.
authors.forename: Ian L
authors.initials: IL
authors.lastname: Jones
authors.forename: Felicity K
authors.initials: FK
authors.lastname: Moore
authors.forename: Christina L L
authors.initials: CL
authors.lastname: Chai
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D032661:Cordyceps / Q000737:chemistry; D015394:Molecular Structure; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D011728:Pyridones; C437383:cordypyridone A; C437384:cordypyridone B