Effect of afobazole on mitochondrial monoamine oxidase A activity in vitro.
Selective anxiolytic afobazole (1 mM) inhibits monoamine oxidase A activity in mitochondria from rat brain and liver (IC(50) 0.36 and 0.43, respectively). Effect of the compound does not depend on the time of preincubation with mitochondria. Triple washout of mitochondria is followed by complete recovery of initial enzyme activity.
Voronin
M V
MV
Laboratory for Pharmacogenetics, V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. niipharm@mail.ru
Aksenova
L N
LN
Buneena
O A
OA
Medvedev
A E
AE
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D008995:Monoamine Oxidase / Q000187:drug effects*; D009025:Morpholines / Q000494:pharmacology*; D051381:Rats
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D009025:Morpholines; D008995:Monoamine Oxidase