title: An amphiphilic ruthenium(II)-polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent.
abstract: An amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0+/-26.8GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section.
authors.affiliation: Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China.
authors.forename: Chun-Ting
authors.initials: CT
authors.lastname: Poon
authors.forename: Pui-Shan
authors.initials: PS
authors.lastname: Chan
authors.forename: Cornelia
authors.initials: C
authors.lastname: Man
authors.forename: Feng-Lei
authors.initials: FL
authors.lastname: Jiang
authors.forename: Ricky Ngok Shun
authors.initials: RN
authors.lastname: Wong
authors.forename: Nai-Ki
authors.initials: NK
authors.lastname: Mak
authors.forename: Daniel W J
authors.initials: DW
authors.lastname: Kwong
authors.forename: Sai-Wah
authors.initials: SW
authors.lastname: Tsao
authors.forename: Wai-Kwok
authors.initials: WK
authors.lastname: Wong
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D006801:Humans; D021621:Imaging, Three-Dimensional; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use; D010778:Photochemotherapy; D017785:Photons; D017319:Photosensitizing Agents / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use; D013050:Spectrometry, Fluorescence
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; C547388:bis(bipyridine)(((10',15',20'-triphenyl)porphyrin(5'-p-phenoxy-5-ethanamido))-1,10-phenanthroline)ruthenium(II)