Adipose tissue-derived nerve growth factor and brain-derived neurotrophic factor: results from experimental stress and diabetes.
Recently, adipobiology (adiposcience) became a focus of numerous studies showing that the adipose tissue is the body's largest endocrine and paracrine organ producing multiple signaling proteins collectively designated adipokines; at present these include more than hundred proteins. However, studies on adipobiology of neurotrophins have recently emerged, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) being examples of adipose-derived neurotrophins. Here we present data showing that NGF and BDNF are expressed in both white and brown adipose tissue following experimental stress (in mice) and in type 1 diabetes (in rats). We suggest that both neurotrophic and metabotrophic potentials of NGF and BDNF may be involved in the molecular mechanism of stress and diabetes and consequently, in the pathogenesis of cardiometabolic diseases.
Sornelli
Federica
F
Institute of Neurobiology and Molecular Medicine, CNR-NGF Section, Via del Fosso di Fiorano 64/65, I-00143 Rome, Italy.
Fiore
Marco
M
Chaldakov
George N
GN
Aloe
Luigi
L
D052437:Adipocytes, Brown / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism*; D052436:Adipose Tissue, White / Q000378:metabolism; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D008297:Male; D051379:Mice; D020932:Nerve Growth Factor / Q000378:metabolism*; D051381:Rats; D013312:Stress, Physiological
D019208:Brain-Derived Neurotrophic Factor; D020932:Nerve Growth Factor