Lack of association between antipsychotic-induced extrapyramidal symptoms and polymorphisms in dopamine metabolism and transport genes.
The purpose of this study was to investigate the relationship between functional polymorphisms in genes coding for dopamine metabolism and transport enzymes and the incidence of acute antipsychotic (AP)-induced extrapyramidal symptoms (EPS). We did not find evidence of the involvement of these polymorphisms in the predisposition towards or protection from EPS.
Gassó
Patricia
P
Dept. Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Barcelona, Spain.
Mas
Sergi
S
Crescenti
Anna
A
Alvarez
Santi
S
Parramon
Gemma
G
Garcia-Rizo
Clemente
C
Parellada
Eduard
E
Bernardo
Miquel
M
Lafuente
Amalia
A
D014150:Antipsychotic Agents / Q000009:adverse effects*; D001480:Basal Ganglia Diseases / Q000139:chemically induced* / Q000235:genetics*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy; D018598:Minisatellite Repeats / Q000235:genetics; D008995:Monoamine Oxidase / Q000235:genetics*; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic / Q000235:genetics*; D012189:Retrospective Studies
D014150:Antipsychotic Agents; D050483:Dopamine Plasma Membrane Transport Proteins; D008995:Monoamine Oxidase