title: The application of NMR spectroscopy to functional glycomics.
abstract: Glycomics which is the study of saccharides and genes responsible for their formation requires the continuous development of rapid and sensitive methods for the identification of glycan structures. It involves glycoanalysis which relies upon the development of methods for determining the structure and interactions of carbohydrates. For the application of functional glycomics to microbial virulence, carbohydrates and their associated metabolic and carbohydrate processing enzymes and respective genes can be identified and exploited as targets for drug discovery, glyco-engineering, vaccine design, and detection and diagnosis of diseases. Glycomics also encompasses the detailed understanding of carbohydrate-protein interactions and this knowledge can be applied to research efforts focused toward the development of vaccines and immunological therapies to alleviate infectious diseases.
authors.affiliation: Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada.
authors.forename: Jean-Robert
authors.initials: JR
authors.lastname: Brisson
authors.forename: Evgeny
authors.initials: E
authors.lastname: Vinogradov
authors.forename: David J
authors.initials: DJ
authors.lastname: McNally
authors.forename: Nam Huan
authors.initials: NH
authors.lastname: Khieu
authors.forename: Ian C
authors.initials: IC
authors.lastname: Schoenhofen
authors.forename: Susan M
authors.initials: SM
authors.lastname: Logan
authors.forename: Harold
authors.initials: H
authors.lastname: Jarrell
mesh_terms: D001671:Biochemistry / Q000379:methods; D002241:Carbohydrates / Q000737:chemistry; D019286:Endopeptidase K / Q000737:chemistry; D054794:Glycomics / Q000379:methods*; D006020:Glycopeptides / Q000737:chemistry; D006023:Glycoproteins / Q000737:chemistry; D006801:Humans; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods; D011134:Polysaccharides / Q000737:chemistry; D011485:Protein Binding; D012984:Software
chemical_list: D002241:Carbohydrates; D006020:Glycopeptides; D006023:Glycoproteins; D008024:Ligands; D011134:Polysaccharides; D019286:Endopeptidase K