Nephropathic complication of type-2 diabetes is following pattern of autoimmune diseases?
The impact of several environmental and genetic factors on diabetes and its complications is well documented. The present study was aimed to examine the serum levels of IL-17A and IFN-gamma as antagonistic cytokines in nephropathic and non-nephropathic type-2 diabetic patients. In this experimental study, serum samples were obtained from 180 type-2 diabetic patients, 100 nephropathic type-2 diabetic patients and 100 healthy controls. Serum levels of IL-17A and IFN-gamma was detected by ELISA. Results of this study showed that the serum level of IFN-gamma was higher in both diabetic patients (nephropathic and non-nephropathic) in comparison to the controls. In terms of IL-17A, while non-nephropathic type-2 diabetic patients showed an increased serum level of it, the other patients group had a lower serum level. Based on these findings, it can be concluded that the lower serum level of IL-17A is possibly associated with nephropathic complications of type-2 diabetes.
Arababadi
Mohammad Kazemi
MK
Dept. of Microbiology, Hematology and Immunology, Faculty of Medicine, Rafsanjan University of Medical Science, Rafsanjan, Iran. kazemim@modares.ac.ir
Nosratabadi
Reza
R
Hassanshahi
Gholamhossein
G
Yaghini
Narges
N
Pooladvand
Vahid
V
Shamsizadeh
Ali
A
Hakimi
Hamid
H
Derakhshan
Reza
R
D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D004777:Environment; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D020381:Interleukin-17 / Q000097:blood*; D007492:Iran; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D020381:Interleukin-17; D007371:Interferon-gamma