title: Chromone glycosides and hepatoprotective constituents of Hypericum erectum.
abstract: Two chromone glycosides, hyperimone A [7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(1-methylethyl)-4H-1-benzopyran-4-one (1)] and hyperimone B [7-(beta-D-glucopyranosyloxy)-5-hydroxy-3-methyl-4H-1-benzopyran-4-one (2)], together with six known compounds were isolated from the methanolic extract of the whole plant of Hypericum erectum. 1,3,5,6-Tetrahydroxyxanthone (5) and I3, II8-biapigenin (6) showed moderate hepatoprotective activity with EC(50) values of 160.2 +/- 0.6 microM and 217.7 +/- 1.3 microM, respectively, against tacrine-induced cytotoxicity in HepG2 cells.
authors.affiliation: Key Laboratory of Organism Functional Factors of the Changbai Mountain, College of Pharmacy, Yanbian University, Yanji, Jilin Province, China.
authors.forename: Ren Bo
authors.initials: RB
authors.lastname: An
authors.forename: Gil Saeng
authors.initials: GS
authors.lastname: Jeong
authors.forename: Jin-Seon
authors.initials: JS
authors.lastname: Beom
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Sohn
authors.forename: Youn Chul
authors.initials: YC
authors.lastname: Kim
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D015394:Molecular Structure; D020011:Protective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013619:Tacrine / Q000494:pharmacology
chemical_list: D002867:Chromones; D006027:Glycosides; D020011:Protective Agents; D013619:Tacrine