title: Evaluation of membrane oxygenators and reservoirs in terms of capturing gaseous microemboli and pressure drops.
abstract: An increasing amount of evidence points to cerebral embolization during cardiopulmonary bypass (CPB) as the principal etiologic factor of neurologic complications. In this study, the capability of capturing and classification of gaseous emboli and pressure drop of three different membrane oxygenators (Sorin Apex, Terumo Capiox SX25, Maquet QUADROX) were measured in a simulated adult model of CPB using a novel ultrasound detection and classification quantifier system. The circuit was primed with 1000 mL heparinized human packed red blood cells and 1000 mL lactated Ringer's solution (total volume 2000 mL, corrected hematocrit 26-28%). After the injection of 5 mL air into the venous line, an Emboli Detection and Classification Quantifier was used to simultaneously record microemboli counts at post-pump, post-oxygenator, and post-arterial filter sites. Trials were conducted at normothermic (35 degrees C) and hypothermic (25 degrees C) conditions. Pre-oxygenator and post-oxygenator pressure were recorded in real time and pressure drop was calculated. Maquet QUADROX membrane oxygenator has the lowest pressure drops compared to the other two oxygenators (P < 0.001). The comparison among the three oxygenators indicated better capability of capturing gaseous emboli with the Maquet QUADROX and Terumo Capiox SX25 membrane oxygenator and more emboli may pass through the Sorin Apex membrane oxygenator. Microemboli counts uniformly increased with hypothermic perfusion (25 degrees C). Different types of oxygenators and reservoirs have different capability of capturing gaseous emboli and transmembrane pressure drop. Based on this investigation, Maquet QUADROX membrane oxygenator has the lowest pressure drop and better capability for capturing gaseous microemboli.
authors.affiliation: The Department of Pediatrics, Penn State Milton S. Hershey Medical Center, Penn State Hershey College of Medicine, Hershey, PA 17033-0850, USA.
authors.forename: Yulong
authors.initials: Y
authors.lastname: Guan
authors.forename: David
authors.initials: D
authors.lastname: Palanzo
authors.forename: Allen
authors.initials: A
authors.lastname: Kunselman
authors.forename: Akif
authors.initials: A
authors.lastname: Undar
mesh_terms: D000328:Adult; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000295:instrumentation*; D004618:Embolism, Air / Q000175:diagnosis*; D006801:Humans; D008955:Models, Cardiovascular; D010107:Oxygenators, Membrane / Q000009:adverse effects*; D011312:Pressure; D013696:Temperature; D014465:Ultrasonics