title: Outcome of 47 consecutive sinus lift operations using aragonitic calcium carbonate associated with autologous platelet-rich plasma: clinical, histologic, and histomorphometrical evaluations.
abstract: BACKGROUND
  The reconstruction of the maxillary bone frequently represents a real challenge for maxillofacial surgeons especially regarding the best choice of a suitable material to produce the required bone augmentation.
  
  
  OBJECTIVE
  In this study, we summarize our clinical experience on 47 sinus lifts with lateral approach using a mixture of aragonitic calcium carbonate and autologous platelet-rich plasma compared with that of a previous published study in which bovine bone (LADDEC) and autologous bone were used in 50 sinus lift operations (Br J Oral Maxillofac Surg 2005;43:309-313).
  
  
  METHODS
  We subjected 34 patients to sinus lift operation, for a total of 47 sinus lifts, using natural coral as osteoconductive material. This material, combined with autologous platelet-rich plasma, was placed onto the maxillary sinus floor, after carefully lifting the endosteum. Cases were clinically, radiographically, and histologically analyzed. Histomorphometrical analysis, tests of microhardness, and x-ray microanalysis were conducted comparing the various sample to controls obtained from the same patients.
  
  
  CONCLUSIONS
  Histomorphometrical analysis, microhardness test, and x-ray microanalysis demonstrated that the newly formed bone showed morphologic and structural characteristics that were similar for all the grafting materials compared (bovine bone, autologous bone, and coral). Although all the grafting materials did yield good results of maturation of the newly formed bone, best results were achieved using autologous bone.
authors.affiliation: Department of Odontostomatologic and Maxillo-Facial Sciences, University Federico II, Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Papa
authors.forename: Antonio
authors.initials: A
authors.lastname: Cortese
authors.forename: Raffaele
authors.initials: R
authors.lastname: Sagliocco
authors.forename: Mauro
authors.initials: M
authors.lastname: Farella
authors.forename: Claudio
authors.initials: C
authors.lastname: Banzi
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Maltarello
authors.forename: Camilla
authors.initials: C
authors.lastname: Pellegrini
authors.forename: Elio
authors.initials: E
authors.lastname: D'Agostino
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: Aimola
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Claudio
mesh_terms: D000328:Adult; D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods; D002119:Calcium Carbonate; D002417:Cattle; D003758:Dental Implantation, Endosseous; D003799:Dental Stress Analysis; D004577:Electron Probe Microanalysis; D006244:Hardness; D006801:Humans; D008443:Maxillary Sinus / Q000601:surgery*; D008875:Middle Aged; D013516:Oral Surgical Procedures, Preprosthetic / Q000379:methods*; D053657:Platelet-Rich Plasma; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes; D002119:Calcium Carbonate