title: Severe exacerbation of multiple self-healing squamous epithelioma (Ferguson-Smith disease) with radiotherapy, which was successfully treated with acitretin.
abstract: We describe the challenging case of a patient presenting with extensive, eruptive mid-facial squamous cell carcinomas (SCCs) and keratoacanthomas (KAs) consequent to radiotherapy. Our patient had a personal and family history of multiple KAs and SCCs. Multiple self-healing squamous epithelioma, otherwise known as Ferguson-Smith disease, was diagnosed. This case presented a therapeutic challenge to preserve tissue and avoid severe facial disfigurement. We found oral acitretin to be the treatment of choice.
authors.affiliation: St John's Institute of Dermatology, Guy's and St Thomas' NHS Trust, London, UK. drsjrobertson@gmail.com
authors.forename: S J
authors.initials: SJ
authors.lastname: Robertson
authors.forename: S J
authors.initials: SJ
authors.lastname: Bashir
authors.forename: G
authors.initials: G
authors.lastname: Pichert
authors.forename: A
authors.initials: A
authors.lastname: Robson
authors.forename: S
authors.initials: S
authors.lastname: Whittaker
mesh_terms: D017255:Acitretin / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D005153:Facial Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D007636:Keratoacanthoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D007641:Keratolytic Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D009381:Neoplasms, Radiation-Induced / Q000188:drug therapy; D009386:Neoplastic Syndromes, Hereditary / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D007641:Keratolytic Agents; D017255:Acitretin