Correction of adjuvant arthritis with delphinium extracts and alkaloids.
Antiinflammatory effects of water-alcohol extracts and sum of alkaloids from the aerial part of delphinium under conditions of immune inflammation caused by Freund's complete adjuvant were comparable to activity of orthophen, a classical antiinflammatory drug. Normalizing effects of the studied extracts on hematological and biochemical parameters were demonstrated.
Nesterova
Yu V
YV
Laboratory of Phytopharmacology, Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia. ilz@pharm.tsu.ru
Povetieva
T N
TN
Nagornyak
Yu G
YG
Suslov
N I
NI
Vetoshkina
T V
TV
Andreeva
T I
TI
D000470:Alkaloids / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D031882:Delphinium / Q000737:chemistry*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005121:Extremities; D005620:Freund's Adjuvant / Q000494:pharmacology*; D006940:Hyperemia / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats
D000470:Alkaloids; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D005620:Freund's Adjuvant