Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker.
We have developed photoaffinity probes for gamma-secretase with a nitrobenzenesulfonamide-type linker that can be cleaved with 2-mercaptoethanol under physiological conditions.
Yokoshima
Satoshi
S
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Abe
Yuzo
Y
Watanabe
Naoto
N
Kita
Yoichi
Y
Kan
Toshiyuki
T
Iwatsubo
Takeshi
T
Tomita
Taisuke
T
Fukuyama
Tohru
T
D000544:Alzheimer Disease / Q000201:enzymology; D053829:Amyloid Precursor Protein Secretases / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006868:Hydrolysis; D009578:Nitrobenzenes / Q000138:chemical synthesis / Q000737:chemistry*; D019920:Photoaffinity Labels / Q000138:chemical synthesis / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry*
D004151:Dipeptides; C419410:N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester; D009578:Nitrobenzenes; D019920:Photoaffinity Labels; D013449:Sulfonamides; D053829:Amyloid Precursor Protein Secretases