title: BMP2 signaling in bone development and repair.
abstract: BMPs are best known for their actions as bone formation signals. Recent studies using transgenic mice in which individual osteogenic BMPs have been removed from the limb skeleton have identified BMP2 as a fundamental component of the inherent regenerative capacity of bone. This review summarizes current findings on the specific requirement for BMP2 in bone formation and repair.
authors.affiliation: Department of Developmental Biology, Harvard University School of Dental Medicine, Boston, MA 02115, USA. Vicki_rosen@hsdm.harvard.edu
authors.forename: Vicki
authors.initials: V
authors.lastname: Rosen
mesh_terms: D000328:Adult; D000818:Animals; D001846:Bone Development / Q000235:genetics* / Q000502:physiology; D055396:Bone Morphogenetic Protein 2 / Q000235:genetics / Q000502:physiology*; D001861:Bone Regeneration / Q000235:genetics* / Q000502:physiology; D001842:Bone and Bones / Q000502:physiology; D006801:Humans; D051379:Mice; D008954:Models, Biological; D010012:Osteogenesis / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
chemical_list: C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2