[Papillary carcinoma arising from dyshormonogenetic goiter].
BACKGROUND
Dyshormonogenetic goiter is a genetically determined thyroid hyperplasia due to an enzyme defect in thyroid-hormone synthesis. Malignant transformation is one of the most serious complications, rarely reported in the literature.


METHODS
We report a new case of a 13-year-old boy with goitrous hypothyroidism who consulted for a voluminous goiter. Total thyroidectomy was performed. Histopathological examination revealed multiple foci of papillary carcinoma with a lymph node metastasis.


CONCLUSIONS
Dyshormonogenetic goiter is a rare entity, representing one of the causes of congenital hypothyroidism. It is morphologically characterized by architectural and cellular pleomorphism that may mimic thyroid malignancy and cause difficulties in differential diagnosis.
Kallel
R
R
Laboratoire d'anatomie et de cytologie pathologiques, CHU Habib Bourguiba, 3029 Sfax, Tunisie. rim.kallel@yahoo.fr
Mnif Hachicha
L
L
Mnif
M
M
Hammami
B
B
Ayadi
L
L
Bahri
I
I
Ghorbel
A
A
Abid
M
M
Makni
S
S
Boudawara
T
T
D000293:Adolescent; D002291:Carcinoma, Papillary / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003409:Congenital Hypothyroidism / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D003937:Diagnosis, Differential; D006042:Goiter / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D006965:Hyperplasia; D008207:Lymphatic Metastasis; D008297:Male; D009154:Mutation; D013961:Thyroid Gland / Q000473:pathology; D013963:Thyroid Hormones / Q000096:biosynthesis / Q000235:genetics; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy
D013963:Thyroid Hormones