Cefuroxime dilution error.
OBJECTIVE
To present clinical findings of a cluster of cases of inadvertent high-dose intracameral cefuroxime injection after uneventful phacoemulsification cataract surgery.


METHODS
Six eyes of 6 patients (mean age 68.33 years, range 61-75, 4 male, 2 female) were operated on the same day by the same surgeon. At the end of surgery, 3 mg in 0.1 mL cefuroxime (30 mg/mL, Zinnat, GlaxoSmithKline) was erroneously injected into anterior chamber of 6 eyes. Incorrect dilution of cefuroxime was noticed at the end of operation day.


RESULTS
The 6 patients were followed up very closely every day during the first week. No adverse reaction or inflammation was observed at postoperative examination. All patients achieved 20/20 or better vision at the end of the first week.


CONCLUSIONS
Inadvertent intracameral (3 mg in 0.1 mL) cefuroxime injection did not cause any detectable adverse effect on ocular tissues.
Sakarya
Yasar
Y
Gozmer Eye Center, Denizli, Turkey. yasarsakarya@yahoo.com
Sakarya
Rabia
R
D000368:Aged; D000867:Anterior Chamber; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002444:Cefuroxime / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D009877:Endophthalmitis / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008297:Male; D008508:Medication Errors; D008875:Middle Aged; D018918:Phacoemulsification / Q000379:methods*; D019999:Pharmaceutical Solutions; D013530:Surgical Wound Infection / Q000517:prevention & control
D000900:Anti-Bacterial Agents; D019999:Pharmaceutical Solutions; D002444:Cefuroxime