Prophylactic efficacy of Coriandrum sativum (Coriander) on testis of lead-exposed mice.
Lead poisoning is a worldwide health problem, and its treatment is under investigation. The aim of this study was to access the efficacy of Coriandrum sativum (coriander) in reducing lead-induced changes in mice testis. Animal exposed to lead nitrate showed significant decrease in testicular SOD, CAT, GSH, total protein, and tissue lead level. This was accompanied by simultaneous increase in the activities of LPO, AST, ALT, ACP, ALP, and cholesterol level. Serum testosterone level and sperm density were suppressed in lead-treated group compared with the control. These influences of lead were prevented by concurrent daily administration of C. sativum extracts to some extent. Treating albino mice with lead-induced various histological changes in the testis and treatment with coriander led to an improvement in the histological testis picture. The results thus led us to conclude that administration of C. sativum significantly protects against lead-induced oxidative stress. Further work need to be done to isolate and purify the active principle involved in the antioxidant activity of this plant.
Sharma
Veena
V
Bioscience and Biotechnology Department, Banasthali University, District Tonk, Banasthali, 304022, Rajasthan, India. veenasharma003@gmail.com
Kansal
Leena
L
Sharma
Arti
A
D000135:Acid Phosphatase / Q000378:metabolism; D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D028526:Coriandrum / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000378:metabolism; D007854:Lead / Q000008:administration & dosage / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D009566:Nitrates / Q000008:administration & dosage / Q000633:toxicity; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry; D013076:Sperm Count; D013482:Superoxide Dismutase / Q000378:metabolism; D013733:Testicular Diseases / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013739:Testosterone / Q000097:blood; D016896:Treatment Outcome
D009566:Nitrates; D010936:Plant Extracts; D007854:Lead; D013739:Testosterone; C017461:lead nitrate; D002784:Cholesterol; D002374:Catalase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D005978:Glutathione