title: Tissue Doppler evaluation of the effects of major lung resection on cardiac functions.
abstract: OBJECTIVE
  The aim of our study was to evaluate the influence of lung resection on cardiac functions by using tissue Doppler echocardiography.
  
  
  METHODS
  Nineteen consecutive patients (15 males, 4 females; mean age 55+/-8 years) undergoing major lung surgery (16 lobectomy, 3 pneumonectomy) were evaluated in a prospective design. Malignant lung cancer (n=15, 79%) was the major cause for lung surgery. Exclusion criteria were a history of myocardial infarction, angina, atrial fibrillation, valvular heart disease, major arrhythmias, diastolic dysfunction, heart surgery, and FEV1/FVC ratio lower than 60%. Two-dimensional Doppler echocardiography and tissue Doppler imaging (TDI) were performed one or two days before surgery and 4+/-2 weeks postoperatively.
  
  
  RESULTS
  Compared to the preoperative measurements, right and left atrial and ventricular dimensions did not differ after surgery (p>0.05). Left ventricular ejection fraction, left ventricular end-systolic and end-diastolic volumes were preserved postoperatively. The following Doppler parameters showed significant changes after surgery: mitral A wave (92+/-23 cm/sec vs. 105+/-27 cm/sec, p=0.005), mitral E/A ratio (1.0+/-0.2 vs. 0.8+/-0.2, p=0.001), tricuspid A wave (65+/-19 cm/sec vs. 80+/-30 cm/sec, p=0.006), and tricuspid E deceleration time (327+/-68 msec vs. 274+/-51 msec, p=0.01). Concerning TDI parameters, there were significant differences in mitral E'/A' ratio (1.0+/-0.4 vs. 0.8+/-0.3, p=0.03) and tricuspid E' wave (9+/-2 cm/sec vs. 8+/-3 cm/sec, p=0.03) after surgery.
  
  
  CONCLUSIONS
  Findings of our study suggest that systolic functions are preserved but diastolic functions are affected after major lung resection in a relatively short time period.
authors.affiliation: Department of Cardiology, Başkent University, Adana, Turkey. kardiyoloji@yahoo.com
authors.forename: Yücel
authors.initials: Y
authors.lastname: Cölkesen
authors.forename: Tayfun
authors.initials: T
authors.lastname: Açil
authors.forename: Alper
authors.initials: A
authors.lastname: Findikçioğlu
authors.forename: Abdullah
authors.initials: A
authors.lastname: Tekin
authors.forename: Dalokay
authors.initials: D
authors.lastname: Kiliç
authors.forename: Bülent
authors.initials: B
authors.lastname: Ozin
authors.forename: Haldun
authors.initials: H
authors.lastname: Müderrisoğlu
mesh_terms: D015150:Echocardiography, Doppler; D005260:Female; D006321:Heart / Q000502:physiology* / Q000503:physiopathology; D006325:Heart Atria / Q000000981:diagnostic imaging; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology; D011013:Pneumonectomy / Q000009:adverse effects; D011446:Prospective Studies; D013318:Stroke Volume; D014261:Tricuspid Valve / Q000000981:diagnostic imaging / Q000503:physiopathology; D016277:Ventricular Function, Left