title: Effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice.
abstract: We studied the effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice. A single administration of propolis caused no significant effect on both antigen-induced nasal rubbing and sneezing at a dose of 1000 mg/kg, but a significant inhibition was observed after repeated administration for 2 weeks at this dose. Propolis caused no significant inhibitory effect on the production of total IgE level after repeated administration of 1000 mg/kg. The drug also caused no significant inhibition of histamine-induced nasal rubbing and sneezing at a dose of 1000 mg/kg. On the other hand, propolis significantly inhibited histamine release from rat mast cells induced by antigen and compound 48/80 at a concentration of more than 10 microg/ml. These results clearly demonstrated that propolis may be effective in the relief of symptoms of allergic rhinitis through inhibition of histamine release.
authors.affiliation: Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Shinmei
authors.forename: Haruna
authors.initials: H
authors.lastname: Yano
authors.forename: Yoto
authors.initials: Y
authors.lastname: Kagawa
authors.forename: Kana
authors.initials: K
authors.lastname: Izawa
authors.forename: Masaaki
authors.initials: M
authors.lastname: Akagi
authors.forename: Toshio
authors.initials: T
authors.lastname: Inoue
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kamei
mesh_terms: D000485:Allergens / Q000008:administration & dosage* / Q000276:immunology; D000818:Animals; D001938:Brazil; D006632:Histamine / Q000008:administration & dosage / Q000276:immunology; D007073:Immunoglobulin E / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009666:Nose / Q000187:drug effects* / Q000276:immunology*; D011429:Propolis / Q000494:pharmacology / Q000627:therapeutic use*; D011537:Pruritus / Q000276:immunology / Q000517:prevention & control*; D051381:Rats; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology / Q000517:prevention & control*; D012912:Sneezing / Q000187:drug effects* / Q000276:immunology
chemical_list: D000485:Allergens; D007073:Immunoglobulin E; D006632:Histamine; D011429:Propolis