title: [Predictive factors of acquisition of epidemic extended-spectrum beta-lactamase-producing Escherichia coli].
abstract: The aim of the study was to determine predictive factors of epidemic extended spectrum beta-lactamase-producing Escherichia coli acquisition. All patients presenting any type of culture positive for ESBL-producing E. coli between November 2006 and October 2007 were included. An epidemic case was defined as a patient colonized with a clonal strain having epidemiological link with an another patient harbouring the same strain. Clinical and administrative data were recorded. Groups were compared by univariate and multivariate analysis using SAS software. Were included in this study 148 patients: 60 epidemic and 88 sporadic cases. Multivariate analysis showed several predictive factors of epidemic strain acquisition: female gender, high Charlson index, treatment by amoxicillin or ticarcillin-clavulanic acid, admission to emergency unit and hospitalisation in a high number of different care units. Identification of predictive factors of epidemic ESBL-producing E. coli strains acquisition may help to limit cross transmission of such strains.
authors.affiliation: Unité de Recherche Clinique, CHU de Reims, Avenue du Général-Koenig, 51092 Reims cedex, France. cbarbe@chu-reims.fr
authors.forename: C
authors.initials: C
authors.lastname: Barbe
authors.forename: A
authors.initials: A
authors.lastname: Fusellier
authors.forename: F
authors.initials: F
authors.lastname: Bureau Chalot
authors.forename: L
authors.initials: L
authors.lastname: Brasme
authors.forename: V
authors.initials: V
authors.lastname: Vernet Garnier
authors.forename: C
authors.initials: C
authors.lastname: de Champs
authors.forename: O
authors.initials: O
authors.lastname: Bajolet
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015331:Cohort Studies; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology*; D003953:Diagnosis-Related Groups; D004196:Disease Outbreaks; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology*; D029968:Escherichia coli Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005602:France / Q000453:epidemiology; D006757:Hospital Units; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; D001618:beta-Lactamases