Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs.
Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human cancer cell lines.
Fürst
Rita
R
Department of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090 Vienna, Austria.
Zupkó
István
I
Berényi
Agnes
A
Ecker
Gerhard F
GF
Rinner
Uwe
U
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D003521:Cyclopropanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D050257:Tubulin Modulators / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D000970:Antineoplastic Agents; D003521:Cyclopropanes; D013267:Stilbenes; D050257:Tubulin Modulators; C058728:fosbretabulin