Self-hardening calcium deficient hydroxyapatite/gelatine foams for bone regeneration.
In this work gelatine was used as multifunctional additive to obtain injectable self-setting hydroxyapatite/gelatine composite foams for bone regeneration. The foaming and colloidal stabilization properties of gelatine are well known in food and pharmaceutical applications. Solid foams were obtained by foaming liquid gelatine solutions at 50 degrees C, followed by mixing them with a cement powder consisting of alpha tricalcium phosphate. Gelatine addition improved the cohesion and injectability of the cement paste. After setting the foamed paste transformed into a calcium deficient hydroxyapatite. The final porosity, pore interconnectivity and pore size were modulated by modifying the gelatine content in the liquid phase.
Montufar
Edgar B
EB
Department of Materials Science and Metallurgy, Technical University of Catalonia, Av. Diagonal 647, 08028, Barcelona, Spain.
Traykova
Tania
T
Schacht
Etienne
E
Ambrosio
Luigi
L
Santin
Matteo
M
Planell
Josep A
JA
Ginebra
Maria-Pau
MP
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001843:Bone Cements; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry; D002118:Calcium / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry; D002417:Cattle; D003102:Colloids / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry*; D016062:Porosity; D013696:Temperature; D013997:Time Factors; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; D003102:Colloids; C485828:alpha-tricalcium phosphate; D005780:Gelatin; D017886:Durapatite; D002118:Calcium