title: Micro-RNAs: viral genome and robustness of gene expression in the host.
abstract: For comparing RNA rings or hairpins with reference or random ring sequences, circular versions of distances and distributions like those of Hamming and Gumbel are needed. We define these circular versions and we apply these new tools to the comparison of RNA relics (such as micro-RNAs and tRNAs) with viral genomes that have coevolved with them. Then we show how robust are the regulation networks incorporating in their boundary micro-RNAs as sources or new feedback loops involving ubiquitous proteins like p53 (which is a micro-RNA transcription factor) or oligopeptides regulating protein translation. Eventually, we propose a new coevolution game between viral and host genomes.
authors.affiliation: Faculty of Medicine, University Joseph Fourier, Grenoble, TIMC-IMAG UMR UJF/CNRS 5525, 38700 La Tronche, France. jacques.demongeot@imag.fr
authors.forename: Jacques
authors.initials: J
authors.lastname: Demongeot
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Drouet
authors.forename: Adrien
authors.initials: A
authors.lastname: Elena
authors.forename: Andrès
authors.initials: A
authors.lastname: Moreira
authors.forename: Yassine
authors.initials: Y
authors.lastname: Rechoum
authors.forename: Sylvain
authors.initials: S
authors.lastname: Sené
mesh_terms: D015967:Gene Expression Regulation, Viral / Q000235:genetics*; D016679:Genome, Viral / Q000235:genetics*; D054884:Host-Pathogen Interactions / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009690:Nucleic Acid Conformation
chemical_list: D035683:MicroRNAs