title: Cholesterol secosterol adduction inhibits the misfolding of a mutant prion protein fragment that induces neurodegeneration.
authors.affiliation: The Scripps-Oxford Laboratory, Department of Biochemistry, University of Oxford, South Parks Rd., Oxford OX13QU, UK.
authors.forename: Johanna C
authors.initials: JC
authors.lastname: Scheinost
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Witter
authors.forename: Grant E
authors.initials: GE
authors.lastname: Boldt
authors.forename: John
authors.initials: J
authors.lastname: Offer
authors.forename: Paul
authors.initials: P
authors.lastname: Wentworth
mesh_terms: D000447:Aldehydes / Q000494:pharmacology; D000818:Animals; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000494:pharmacology; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D050505:Mutant Proteins / Q000494:pharmacology*; D019636:Neurodegenerative Diseases / Q000209:etiology*; D010446:Peptide Fragments / Q000235:genetics / Q000494:pharmacology*; D011328:Prions / Q000235:genetics / Q000494:pharmacology*; D011487:Protein Conformation; D017510:Protein Folding / Q000187:drug effects*; D055503:Protein Multimerization
chemical_list: D000447:Aldehydes; D050505:Mutant Proteins; D010446:Peptide Fragments; D011328:Prions; C512175:atheronal-B; D002784:Cholesterol