title: A new hydrogel drug delivery system based on hydroxyethylstarch derivatives.
abstract: A new method has been developed to produce a drug delivery system (DDS) for proteins and peptides. Employing a water-in-water emulsion technique with polyethylenglycol and hydroxyethylstarch substituted by hydroxyethylmethacrylate and a subsequent photopolymerization, microspheres can be produced. This process can be carried out with proteins present in the cross-linkable phase and without the need of any organic solvents. The hydrogel microparticles are promising to fulfil the requirements for a DDS regarding biocompatibility and biodegradability.
authors.affiliation: Institut für Technische Chemie, TU Braunschweig.
authors.forename: Steffen
authors.initials: S
authors.lastname: Harling
authors.forename: Ariane
authors.initials: A
authors.lastname: Schwoerer
authors.forename: Kristin
authors.initials: K
authors.lastname: Scheibe
authors.forename: Rolf
authors.initials: R
authors.lastname: Daniels
authors.forename: Henning
authors.initials: H
authors.lastname: Menzel
mesh_terms: D000818:Animals; D002645:Chickens; D004337:Drug Carriers / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D006895:Hydroxyethyl Starch Derivatives / Q000737:chemistry*; D008863:Microspheres; D009113:Muramidase / Q000008:administration & dosage; D011092:Polyethylene Glycols / Q000737:chemistry; D011506:Proteins / Q000008:administration & dosage*
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D006895:Hydroxyethyl Starch Derivatives; D011506:Proteins; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; C421864:hen egg lysozyme; D009113:Muramidase