A controlled release system of superoxide dismutase by electrospun fiber and its antioxidant activity in vitro.
In this paper, a new controlled release system of superoxide dismutase was developed by electrospun composite fibers. Highly loading efficacy of sod from 85.6 to 98.0% was achieved. The superoxide dismutase can be released from the system for 234 h, and obvious initial burst release of superoxide dismutase in vitro was not observed. In vitro release rate of superoxide dismutase in the first 66 h basically is faster than the corresponding rate at a later stage. Antioxidant activity of the released superoxide dismutase was still high, and it remained stable during the preparation by electrospinning and release experiment. We hope this composite system be used as an implanted form, in the treatment for several disease involved with the superoxide radical in the future.
Chen
Ping
P
Department of Chemistry and Food Science, Chizhou College, Jianshe Road 169, Chizhou, Anhui, 247000, People's Republic of China. chenping8864@yahoo.com.cn
Sun
Yu-Jun
YJ
Zhu
Zi-Chun
ZC
Wang
Rui-Xia
RX
Shi
Xiu-Dong
XD
Lin
Chong
C
Ye
Yu-Ting
YT
D000975:Antioxidants / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D004563:Electrochemistry / Q000379:methods; D004789:Enzyme Activation; D008422:Materials Testing; D012399:Rotation; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000737:chemistry*
D000975:Antioxidants; D003692:Delayed-Action Preparations; D013482:Superoxide Dismutase