Assembly of checkpoint and repair machineries at DNA damage sites.
The remarkably coordinated nature of the DNA damage response pathway relies on numerous mechanisms that facilitate the assembly of checkpoint and repair factors at DNA breaks. Post-translational modifications on and around chromatin have critical roles in allowing the timely and sequential assembly of DNA damage responsive elements at the vicinity of DNA breaks. Notably, recent advances in forward genetics and proteomics-based approaches have enabled the identification of novel components within the DNA damage response pathway, providing a more comprehensive picture of the molecular network that assists in the detection and propagation of DNA damage signals.
Huen
Michael S Y
MS
Department of Anatomy, Centre for Cancer Research, University of Hong Kong, L1-59, Laboratory Block, 21 Sassoon Road, Hong Kong SAR.
Chen
Junjie
J
D000818:Animals; D002453:Cell Cycle; D002843:Chromatin / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair / Q000502:physiology*; D006801:Humans; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction
D002843:Chromatin