Expression of estrogen and progesterone receptors in vestibular schwannomas and their clinical significance.
OBJECTIVE
The objective was to determine the expression of estrogen and progesterone receptors in vestibular schwannomas as well as to determine predictive factors for estrogen and progesterone receptor positivity.


METHODS
The study included 100 cases of vestibular schwannomas operated from January 2006 to June 2009. The clinical details were noted from the medical case files. Formaldehyde-fixed parafiin-embedded archival vestibular schwannomas specimens were used for the immunohistochemical assessment of estrogen and progesterone receptors.


RESULTS
Neither estrogen nor progesterone receptors could be detected in any of our cases by means of well known immunohistochemical method using well documented monoclonal antibodies. In the control specimens, a strongly positive reaction could be seen.


CONCLUSIONS
No estrogen and progesterone receptor could be found in any of our 100 cases of vestibular schwannomas. Hence our study does not support a causative role of estrogen and progesterone in the growth of vestibular schwannoma as well as hormonal manipulation in the treatment of this tumor.
Jaiswal
Sushila
S
Department of Pathology and Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, India. sushilapath@yahoo.com
Agrawal
Vinita
V
Jaiswal
Awadhesh Kumar
AK
Pandey
Rakesh
R
Mahapatra
Ashok Kumar
AK
D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D009442:Neurilemmoma / Q000378:metabolism* / Q000473:pathology; D016612:Paraffin Embedding; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D015837:Vestibular Diseases / Q000378:metabolism* / Q000473:pathology
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone