Striatal "function-metabolism" mismatch on F-18 FDG/F-18 FDOPA PET/CT.
Decrease in gray matter metabolism following cranial irradiation has been documented, but the functional relevance of this finding has not been documented. This case of "function-metabolism" mismatch in the striatum following radiation for a grade III frontoparietal glioma demonstrates that the down-regulation of glucose metabolism as demonstrated by F-18 fluorodeoxyglucose positron emission tomography/computed tomography is associated with preservation of presynaptic dopaminergic function by the striatal neurons which was demonstrated on a correlative l-3,4-dihydroxy-6-F-flurophenylalanine (F-18 FDOPA) study. The reversibility of this down-regulation is demonstrated in a follow-up scan further proving that there is no neurodegeneration involved.
Tripathi
Madhavi
M
Division of PET Imaging, Molecular Imaging and Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India. madhu_deven@yahoo.com
Sharma
Rajnish
R
Jaimini
Abhinav
A
Garg
Gunjan
G
Khurana
Aditi
A
D'Souza
Maria
M
Varshney
Raunak
R
Mishra
Anil
A
Mondal
Anupam
A
D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000378:metabolism*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009837:Oligodendroglioma / Q000000981:diagnostic imaging / Q000532:radiotherapy; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine