JAK2 gets histone H3 rolling.
Activation of JAK2 is implicated in normal hematopoiesis as well as oncogenic transformation. A paper in the recent issue of Nature demonstrates that phosphorylation of histone H3 by JAK2 releases the transcriptional repressor HP1alpha from chromatin, resulting in gene transcription.
Sattler
Martin
M
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Griffin
James D
JD
D045744:Cell Line, Tumor; D000090266:Chromobox Protein Homolog 5; D006657:Histones / Q000378:metabolism*; D006801:Humans; D053614:Janus Kinase 2 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010766:Phosphorylation
C000715594:CBX5 protein, human; D006657:Histones; D000090266:Chromobox Protein Homolog 5; C507924:JAK2 protein, human; D053614:Janus Kinase 2