A new hydrogel drug delivery system based on hydroxyethylstarch derivatives.
A new method has been developed to produce a drug delivery system (DDS) for proteins and peptides. Employing a water-in-water emulsion technique with polyethylenglycol and hydroxyethylstarch substituted by hydroxyethylmethacrylate and a subsequent photopolymerization, microspheres can be produced. This process can be carried out with proteins present in the cross-linkable phase and without the need of any organic solvents. The hydrogel microparticles are promising to fulfil the requirements for a DDS regarding biocompatibility and biodegradability.
Harling
Steffen
S
Institut für Technische Chemie, TU Braunschweig.
Schwoerer
Ariane
A
Scheibe
Kristin
K
Daniels
Rolf
R
Menzel
Henning
H
D000818:Animals; D002645:Chickens; D004337:Drug Carriers / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D006895:Hydroxyethyl Starch Derivatives / Q000737:chemistry*; D008863:Microspheres; D009113:Muramidase / Q000008:administration & dosage; D011092:Polyethylene Glycols / Q000737:chemistry; D011506:Proteins / Q000008:administration & dosage*
D004337:Drug Carriers; D004655:Emulsions; D006895:Hydroxyethyl Starch Derivatives; D011506:Proteins; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; C421864:hen egg lysozyme; D009113:Muramidase