Effect of imipramine on nerve excitability in GC rats.
Imipramine test (7.5 mg/kg) revealed a persistent positive reaction of Wistar rats, which manifested in reduced excitability of animals. Oral administration of imipramine solution was followed by unstable behavioral reactions in GC rats. Norepinephrine concentration in the cortical and limbic regions of these animals remained unchanged, while plasma corticosterone concentration decreased to the control level and did not differ from that in Wistar rats. Our results indicate that imipramine has a modulatory effect on destabilization of the adaptive system in catatonic GC rats.
Alekhina
T A
TA
Laboratory of Evolutionary Genetics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Russia. alek@bionet.nsc.ru
Ukolova
T N
TN
Kuznetsova
N V
NV
Palchikova
N A
NA
Rjazanova
M A
MA
Klotchkov
D V
DV
D000284:Administration, Oral; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002389:Catatonia / Q000188:drug therapy; D003345:Corticosterone / Q000097:blood; D004195:Disease Models, Animal; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism
D000929:Antidepressive Agents, Tricyclic; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D007099:Imipramine; D003345:Corticosterone; D009638:Norepinephrine