Disseminated Mycobacterium scrofulaceum infection in a child with interferon-gamma receptor 1 deficiency.
Disseminated disease caused by non-tuberculous, environmental mycobacteria (EM) reflects impaired host immunity. Disseminated disease caused by Mycobacterium scrofulaceum has primarily been reported in patients with AIDS. Moreover, observing M. scrofulaceum as the agent of localized disease in childhood has become increasingly rare. We report the first case of disseminated disease caused by M. scrofulaceum in a child with inherited interferon-gamma receptor 1 (IFN-gammaR1) complete deficiency. As in this case, mycobacterial bone infections in IFN-gammaR1 deficiency can sometimes mimic the clinical picture of chronic recurrent multifocal osteomyelitis.
Marazzi
Maria Grazia
MG
Infectious Unit and University of Genoa, G. Gaslini Scientific Institute, Largo G. Gaslini 5, 16147 Genoa, Italy. mgmarazzi@ospedale-gaslini.ge.it
Chapgier
Ariane
A
Defilippi
Anna-Carla
AC
Pistoia
Vito
V
Mangini
Sara
S
Savioli
Cesarina
C
Dell'Acqua
Anna
A
Feinberg
Jacqueline
J
Tortoli
Enrico
E
Casanova
Jean-Laurent
JL
D002675:Child, Preschool; D005528:Foot / Q000382:microbiology / Q000473:pathology; D006225:Hand / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007866:Leg / Q000382:microbiology / Q000473:pathology; D008297:Male; D009165:Mycobacterium Infections, Nontuberculous / Q000382:microbiology / Q000473:pathology; D015359:Mycobacterium scrofulaceum / Q000302:isolation & purification*; D017471:Receptors, Interferon / Q000172:deficiency*; D014394:Tuberculosis, Osteoarticular / Q000382:microbiology / Q000473:pathology; D000096743:Interferon gamma Receptor
D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor