title: Corticomedullary mixed tumor of the adrenal gland.
abstract: A 34-year-old woman presented with weight gain, hirsutism, recent hypertension and secondary amenorrhea. Laboratory findings showed hypokalemia, elevated cortisol and androgen levels with normal urine metanephrines and normal aldosteronemia. Abdominal magnetic resonance imaging showed a right heterogeneous adrenal mass measuring 4 x 6 cm with mixed component of fat and adrenal tissue suggesting corticosurrenaloma. After right adrenalectomy, blood pressure normalized and hypokalemia resolved. In the postoperative course, the patient presented adrenal insufficiency treated with hydrocortisone hemisuccinate. Histological examination showed a single tumor mass composed of an admixed population of adrenal cortical and medullary cells. Immunohistochemical evaluation was positive for chromogranin A.
authors.affiliation: Department of Endocrinology, Farhat Hached Hospital, Sousse 4000, Tunisia. sihem t@yahoo.fr
authors.forename: S
authors.initials: S
authors.lastname: Trimeche Ajmi
authors.forename: M
authors.initials: M
authors.lastname: Chadli Chaieb
authors.forename: M
authors.initials: M
authors.lastname: Mokni
authors.forename: R
authors.initials: R
authors.lastname: Braham
authors.forename: K
authors.initials: K
authors.lastname: Ach
authors.forename: A
authors.initials: A
authors.lastname: Maaroufi
authors.forename: L
authors.initials: L
authors.lastname: Chaieb
mesh_terms: D017667:Adipocytes / Q000473:pathology; D000302:Adrenal Cortex / Q000473:pathology*; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000309:Adrenal Insufficiency / Q000188:drug therapy / Q000209:etiology; D000313:Adrenal Medulla / Q000473:pathology*; D000315:Adrenalectomy / Q000009:adverse effects; D000328:Adult; D000568:Amenorrhea; D000728:Androgens / Q000097:blood; D053379:Chromogranin A / Q000032:analysis; D003480:Cushing Syndrome; D003937:Diagnosis, Differential; D005260:Female; D006628:Hirsutism; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension; D007008:Hypokalemia; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D009765:Obesity; D015430:Weight Gain
chemical_list: D000728:Androgens; D053379:Chromogranin A; D006854:Hydrocortisone