[Rapid assessment of the IL-6 cervico-vaginal fluid level in threatening preterm labor].
OBJECTIVE
The aim of the study was to check the cervico-vaginal fluid IL-6 levels using rapid, quantitive test in patients with threatening preterm labor before and after tocolytic treatment.


METHODS
Sixty seven singular pregnant women, between 24 and 36 weeks of gestation, were included into the clinical trial. 35 women who were admitted to the Department due to clinical symptoms of threatened preterm labor formed the study group. 32 women between 24 and 36 gestational week, with uncomplicated pregnancy formed the control group. Levels of IL-6 were measured just after material collection, using fast, quantitative spectrofotometric test.


RESULTS
The cervico-vaginal IL-6 level was higher in the study group (458 pg/mL vs 123 pg/mL; p < 0.05). A significant reduction of cervico-vaginal IL-6 level was observed after two days of tocolytic treatment.


CONCLUSIONS
A bedside, quantitative spectrofotometric method allows for a quick and repeatable assessment of cervico-vaginal IL-6 levels to establish the risk of preterm labor as well as enables the monitoring of the effectiveness of tocolytic treatment.
Rzepka
Rafał
R
Klinika Połoznictwa i Ginekologii, Pomorska Akademia Medyczna, Szczecin. rafalrz@sci.pam.szczecin.pl
Torbé
Andrzej
A
Czajka
Ryszard
R
Kwiatkowski
Sebastian
S
Bartoszek
Małgorzata
M
Cymbaluk
Aneta
A
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D002582:Cervix Mucus / Q000737:chemistry*; D015897:Comorbidity; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis*; D007752:Obstetric Labor, Premature / Q000175:diagnosis* / Q000453:epidemiology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D018570:Risk Assessment; D015149:Tocolytic Agents / Q000008:administration & dosage; D014621:Vagina / Q000378:metabolism; D014626:Vaginal Smears; D016585:Vaginosis, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D055815:Young Adult
D015415:Biomarkers; D015850:Interleukin-6; D015149:Tocolytic Agents