title: Concomitant dehydration mechanisms in single crystals of alpha,alpha-trehalose.
abstract: The dehydration behaviour of alpha,alpha-trehalose (alpha-D-glucopyranosyl alpha-D-glucopyranoside) dihydrate single crystals is investigated by thermomicroscopy, Raman microscopy, and differential scanning calorimetry. The results show at a given stage the simultaneous presence of two polymorphic forms, amorphous material, and movement of a fluid phase. The study also underlines that the characterization of the average phase by conventional XRPD and DSC techniques is not sufficient to describe the dehydration mechanisms of alpha,alpha-trehalose particles. Moreover, it confirms that the dehydration behaviour is mainly driven by heterogeneities and the rate of water loss.
authors.affiliation: La2B-SMS UPRES EA3233, Centre Universitaire d'Evreux, Université de Rouen, Evreux Cedex, France. valerie.dupray@univ-rouen.fr
authors.forename: Valérie
authors.initials: V
authors.lastname: Dupray
authors.forename: Benjamin
authors.initials: B
authors.lastname: Berton
authors.forename: Stephen
authors.initials: S
authors.lastname: Ossart
authors.forename: Hassan
authors.initials: H
authors.lastname: Atmani
authors.forename: Marie-Noëlle
authors.initials: MN
authors.lastname: Petit
authors.forename: Gérard
authors.initials: G
authors.lastname: Coquerel
mesh_terms: D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D003890:Desiccation; D008853:Microscopy; D013059:Spectrum Analysis, Raman; D014199:Trehalose / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water; D014199:Trehalose