title: Cochlear pathology in human temporal bones with otitis media.
abstract: CONCLUSIONS
  Middle and inner ear interactions in otitis media can lead to cochlear pathology. More severe pathological changes observed in the basal turn of the cochlea are consistent with prevalence of sensorineural hearing loss at higher frequencies in patients with otitis media.
  
  
  METHODS
  Of 614 temporal bones with otitis media, 47 with chronic and 35 with purulent otitis media were selected following strict exclusion of subjects with a history of acoustic trauma, head trauma, ototoxic drugs, and other diseases affecting the cochlear labyrinth. Temporal bones with labyrinthine inflammatory changes were further evaluated for loss of hair cells and other histopathologic changes compared to age-matched controls.
  
  
  RESULTS
  In all, 19% of temporal bones with chronic and 9% with purulent otitis media showed labyrinthine inflammatory changes. In chronic otitis media, inflammatory changes were: 56% localized purulent, 22% localized serous, 11% generalized seropurulent, and 11% generalized serous. Inflammatory changes in temporal bones with purulent otitis media included 67% localized purulent and 33% were generalized seropurulent. Pathological findings included: serofibrinous precipitates and inflammatory cells in scala tympani of basal turn and cochlear aqueduct, significant loss of outer and inner hair cells, and significant decrease in area of stria vascularis in the basal turn of the cochlea, as compared to controls.
authors.affiliation: Department of Otolaryngology, University of Minnesota, 420 Delaware Street, Minneapolis, MN 55455, USA. drshrutisj@gmail.com
authors.forename: Shruti
authors.initials: S
authors.lastname: Joglekar
authors.forename: Norimasa
authors.initials: N
authors.lastname: Morita
authors.forename: Sebahattin
authors.initials: S
authors.lastname: Cureoglu
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Schachern
authors.forename: Armin F
authors.initials: AF
authors.lastname: Deroee
authors.forename: Vladimir
authors.initials: V
authors.lastname: Tsuprun
authors.forename: Michael M
authors.initials: MM
authors.lastname: Paparella
authors.forename: Steven K
authors.initials: SK
authors.lastname: Juhn
mesh_terms: D000293:Adolescent; D001309:Auditory Threshold / Q000502:physiology; D001844:Bone Conduction / Q000502:physiology; D018929:Cell Culture Techniques; D002648:Child; D002908:Chronic Disease; D003051:Cochlea / Q000473:pathology*; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008297:Male; D010035:Otitis Media, Suppurative / Q000150:complications / Q000473:pathology*; D013701:Temporal Bone / Q000473:pathology*