Maternal endothelin-1 and cyclic guanosine monophosphate concentrations in pregnancies complicated by pregravid and gestational diabetes mellitus.
OBJECTIVE
Pregnancy complicated by diabetes is associated with increased risk of unfavorable obstetric outcomes. A common abnormality in diabetes is endothelial dysfunction resulting in an altered pattern of vasoactive substance production by the endothelial cells. The aim of study was to assess serum endothelin-1 (ET-1) and cyclic guanosine monophosphate (cGMP) in pregnant women with pregravid (PGDM) or gestational diabetes (GDM).


METHODS
At the time of delivery, serum ET-1, cGMP, glycated hemoglobin (A1c), fructosamine and non-fasting glucose were measured in 19 PGDM, 23 GDM and 18 controls.


RESULTS
ET-1 and cGMP were similar in all groups. In GDM there was a positive association between A1c and ET-1 (r = 0.437; p < 0.05) and cGMP (r = 0.542; p < 0.02). In the controls, but not in PGDM and GDM, we found a positive correlation between ET-1 and cGMP (r = 0.634; p < 0.005). In women with diabetes, an optimal (A1c <6%) or inadequate (A1c >6%) metabolic control of diabetes did not influence ET-1 or cGMP levels.


CONCLUSIONS
In women with PGDM and GDM, serum ET-1 and cGMP were similar to the levels observed in healthy pregnant women. However, the physiological balance between vasoconstrictor and vasodilator substances might be defective in pregnancies complicated by diabetes.
Swiderski
Sławomir
S
Department for Fetomaternal Medicine, Pomeranian Medical University, PL-71-252 Szczecin, Poland.
Celewicz
Zbigniew
Z
Miazgowski
Tomasz
T
Ogonowski
Jarosław
J
D001786:Blood Glucose / Q000378:metabolism; D006152:Cyclic GMP / Q000097:blood*; D016640:Diabetes, Gestational / Q000097:blood*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D019270:Fructosamine / Q000097:blood; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*; D018709:Statistics, Nonparametric
D001786:Blood Glucose; D006152:Cyclic GMP; D019332:Endothelin-1; D019270:Fructosamine; D006442:Glycated Hemoglobin