Propofol interruption of ECT seizure to reduce side-effects: a pilot study.
Fifteen depressed subjects received six bitemporal electroconvulsive therapy (ECT) treatments under etomidate anesthesia. They were randomized to blindly either receive propofol 0.5mg/kg 15s post-stimulus or not. Propofol infusion significantly prevented long seizures, and prevented cognitive decrements in most neuropsychological tests, several significantly. Propofol interruption may clinically help reduce ECT side-effects.
Warnell
Ronald L
RL
Department of Psychiatry, Loma Linda University, 11374 Mountain View Avenue, Loma Linda, CA 92354, USA. rwarnell@llu.edu
Swartz
Conrad M
CM
Thomson
Alice
A
D000368:Aged; D003072:Cognition Disorders / Q000209:etiology* / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004565:Electroconvulsive Therapy / Q000009:adverse effects*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010865:Pilot Projects; D015742:Propofol / Q000627:therapeutic use*; D012640:Seizures / Q000628:therapy*
D006993:Hypnotics and Sedatives; D015742:Propofol