title: Intrathecal liposomal cytarabine in combination with temozolomide in low-grade oligoastrocytoma with leptomeningeal dissemination.
abstract: Leptomeningeal dissemination of low-grade gliomas is an uncommon event. A 43-year old male presented with dizziness, gait ataxia, and diplopia. A nonenhancing lesion in the right cerebellar peduncle was identified, subtotally resected, and diagnosed as a grade II astrocytoma. After one year a nodular spread in the brain and leptomeninges was diagnosed, so the patient started chemotherapy with temozolomide and liposomal cytarabine. Complete remission was achieved after 12 months of treatment and the patient is still free from the disease after a follow-up of 24 months. We suggest that this combination may be a valuable treatment option.
authors.affiliation: Division of Neurology, USSL 22, Via Ospedale 6, 37012 Bussolengo, Verona, Italy. mariagraziapassarin@hotmail.it
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Passarin
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Moretto
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Musso
authors.forename: Sarah
authors.initials: S
authors.lastname: Ottaviani
authors.forename: Barbara
authors.initials: B
authors.lastname: Masotto
authors.forename: Claudio
authors.initials: C
authors.lastname: Ghimenton
authors.forename: Paolo
authors.initials: P
authors.lastname: Iuzzolino
authors.forename: Ebba
authors.initials: E
authors.lastname: Buffone
authors.forename: Roberta
authors.initials: R
authors.lastname: Rudà
authors.forename: Riccardo
authors.initials: R
authors.lastname: Soffietti
authors.forename: Emanuela
authors.initials: E
authors.lastname: Vattemi
authors.forename: Rebecca
authors.initials: R
authors.lastname: Pedersini
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000150:complications / Q000188:drug therapy*; D003561:Cytarabine / Q000627:therapeutic use*; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007278:Injections, Spinal / Q000379:methods; D008081:Liposomes / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications / Q000188:drug therapy*; D009837:Oligodendroglioma / Q000150:complications / Q000188:drug therapy*; D000077204:Temozolomide
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes; D003561:Cytarabine; D003606:Dacarbazine; D000077204:Temozolomide