title: Squamous cell carcinoma arising in a recent plaque of discoid lupus erythematous, in a sun-protected area.
abstract: Squamous cell carcinoma is a known complication reported to occur in chronic discoid lupus erythematosus in sun-exposed areas. We report a patient with systemic lupus erythematosus who developed a squamous cell carcinoma in a recent plaque of discoid lupus erythematosus in a sun-protected area. This article emphasizes the need for a very high index of suspicion for squamous cell carcinoma and repeated biopsies when discoid lupus erythematosus fails to respond to conventional therapy or there is unexplained exacerbation.
authors.affiliation: Department of Dermatology, Westmead Hospital, University of Sydney, Westmead, Australia.
authors.forename: N
authors.initials: N
authors.lastname: Parikh
authors.forename: J
authors.initials: J
authors.lastname: Choi
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.forename: R
authors.initials: R
authors.lastname: Sharma
authors.forename: P
authors.initials: P
authors.lastname: Fernandez-Peñas
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000150:complications* / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000503:physiopathology; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications; D012878:Skin Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology