Fatal liver injury associated with clopidogrel.
Clopidogrel, an adenosine diphosphate receptor blocker, is widely used as an adjunctive antiplatelet therapy in acute coronary syndrome and percutaneous coronary stenting. It appears to be a safe drug with few occurrences of liver side-effects that usually resolved after drug withdrawal. We report a serious liver injury with fatal outcome in a 63-year-old man developed 19 days after starting clopidogrel for percutaneous coronary stenting.
Kastalli
Sarrah
S
Centre National de Pharmacovigilance, 9 Avenue du Dr Zouheir Essafi 1006 Tunis, Tunisia.
El Aïdli
Sihem
S
Zaïem
Ahmed
A
ben Abdallah
Hatem
H
Daghfous
Riadh
R
D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000209:etiology*; D000077144:Clopidogrel; D017809:Fatal Outcome; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D013988:Ticlopidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine