title: Long-term results of endoscopic treatment of vesicoureteric reflux with different tissue-augmenting substances.
abstract: OBJECTIVE
  To review the current literature regarding the outcome of endoscopic treatment of vesicoureteric reflux (VUR) using different tissue-augmenting substances, with special emphasis on long-term efficacy.
  
  
  METHODS
  The current literature, including our own experience, on long-term results after endoscopic treatment was reviewed by MEDLINE/PubMed search.
  
  
  RESULTS
  The short-term results are similar in the majority of series to those of open surgery, but there is a high recurrence rate with use of dextranomer/hyaluronic acid (Deflux) as a tissue-augmenting material.
  
  
  CONCLUSIONS
  There is a significant shortage of evidence-based literature on long-term follow-up after endoscopic correction of VUR utilizing dextranomer/hyaluronic acid. The high recurrence rate that has been reported after Deflux injection highlights a need for close observation beyond routine protocols and appropriate parental counseling upon endoscopic correction, and also the need to search further for alternative tissue-augmenting substances. The algorithm for treating VUR is yet to be finally determined.
authors.affiliation: Pediatric Urology Unit, Department of Urology, Shaare Zedek Medical Center, Faculty of Medical Science, Hebrew University, P.O. Box 3235, Jerusalem 91031, Israel. boris.chertin@gmail.com
authors.forename: Boris
authors.initials: B
authors.lastname: Chertin
authors.forename: Stanislav
authors.initials: S
authors.lastname: Kocherov
mesh_terms: D002648:Child; D004724:Endoscopy / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage; D007267:Injections; D011138:Polytetrafluoroethylene / Q000008:administration & dosage*; D019919:Prosthesis Implantation / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome; D014563:Urodynamics / Q000502:physiology*; D014718:Vesico-Ureteral Reflux / Q000503:physiopathology* / Q000601:surgery*; D055675:Viscosupplements / Q000008:administration & dosage*
chemical_list: D055675:Viscosupplements; D011138:Polytetrafluoroethylene; D006820:Hyaluronic Acid