title: FlyTF: improved annotation and enhanced functionality of the Drosophila transcription factor database.
abstract: FlyTF (http://www.flytf.org) is a database of computationally predicted and/or experimentally verified site-specific transcription factors (TFs) in the fruit fly Drosophila melanogaster. The manual classification of TFs in the initial version of FlyTF that concentrated primarily on the DNA-binding characteristics of the proteins has now been extended to a more fine-grained annotation of both DNA binding and regulatory properties in the new release. Furthermore, experimental evidence from the literature was classified into a defined vocabulary, and in collaboration with FlyBase, translated into Gene Ontology (GO) annotation. While our GO annotations will also be available through FlyBase as they will be incorporated into the genes' official GO annotation in the future, the entire evidence used for classification including computational predictions and quotes from the literature can be accessed through FlyTF. The FlyTF website now builds upon the InterMine framework, which provides experimental and computational biologists with powerful search and filter functionality, list management tools and access to genomic information associated with the TFs.
authors.affiliation: Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Pfreundt
authors.forename: Daniel P
authors.initials: DP
authors.lastname: James
authors.forename: Susan
authors.initials: S
authors.lastname: Tweedie
authors.forename: Derek
authors.initials: D
authors.lastname: Wilson
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Teichmann
authors.forename: Boris
authors.initials: B
authors.lastname: Adryan
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods* / Q000639:trends; D004247:DNA / Q000235:genetics; D030541:Databases, Genetic; D030561:Databases, Nucleic Acid; D030562:Databases, Protein; D029721:Drosophila Proteins / Q000737:chemistry*; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology*; D016247:Information Storage and Retrieval / Q000379:methods; D020407:Internet; D017434:Protein Structure, Tertiary; D012984:Software; D014157:Transcription Factors / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D029721:Drosophila Proteins; D014157:Transcription Factors; D004247:DNA