title: Comparison of a rapid antigen test with nucleic acid testing during cocirculation of pandemic influenza A/H1N1 2009 and seasonal influenza A/H3N2.
abstract: The rapid diagnosis of influenza is critical in optimizing clinical management. Rapid antigen tests have decreased sensitivity in detecting pandemic influenza A/H1N1 2009 virus compared to seasonal influenza A subtypes (53.4% versus 74.2%, P < 0.001). Nucleic acid tests should be used to detect pandemic influenza virus when rapid antigen tests are negative.
authors.affiliation: Centre for Infectious Diseases and Microbiology Laboratory Services, Level 3, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales 2145, Australia. jen.kok@swahs.health.nsw.gov.au
authors.forename: Jen
authors.initials: J
authors.lastname: Kok
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Blyth
authors.forename: Hong
authors.initials: H
authors.lastname: Foo
authors.forename: Jason
authors.initials: J
authors.lastname: Patterson
authors.forename: Janette
authors.initials: J
authors.lastname: Taylor
authors.forename: Kenneth
authors.initials: K
authors.lastname: McPhie
authors.forename: V Mala
authors.initials: VM
authors.lastname: Ratnamohan
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Iredell
authors.forename: Dominic E
authors.initials: DE
authors.lastname: Dwyer
mesh_terms: D000956:Antigens, Viral / Q000276:immunology; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D007251:Influenza, Human / Q000175:diagnosis* / Q000821:virology*; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D021141:Nucleic Acid Amplification Techniques / Q000379:methods*; D012367:RNA, Viral / Q000235:genetics; D012680:Sensitivity and Specificity
chemical_list: D000956:Antigens, Viral; D012367:RNA, Viral