The use of amniotic membrane transplantation for ocular surface reconstruction: a review and series of 58 equine clinical cases (2002-2008).
Amniotic membrane transplantation (AMT) is an effective clinical therapy for reconstruction of the ocular surface in human and veterinary patients. Amnion is avascular and strong, contains antiangiogenic and antiinflammatory properties and growth factors, and has properties that prevent or decrease fibrosis in healing tissue. Indications for its use are steadily growing and include grafting to replace diseased, missing or excised tissue, patching to support diseased tissue during the healing process and as a substrate for the expansion of epithelial cells for transplantation to the cornea. AMT through a combination of mechanical and biologic factors can preserve the integrity of the globe, optimize the visual outcome, and minimize scarring in severely diseased corneas.
Plummer
Caryn E
CE
College of Veterinary Medicine, University of Florida, Department of Small Animal Clinical Sciences, Gainesville, FL, [corrected] USA. plummerc@mail.vetmed.ufl.edu
Ollivier
Franck
F
Kallberg
Maria
M
Brooks
Dennis
D
Barrie
Kathleen
K
Utter
Mary
M
Gelatt
Kirk
K
D000650:Amnion / Q000637:transplantation*; D000818:Animals; D001684:Biological Dressings; D003316:Corneal Diseases / Q000628:therapy*; D006734:Horse Diseases / Q000628:therapy*; D006736:Horses