Potential utility of PPARalpha activation in the prevention of ischemic and drug-induced acute renal damage.
Acute renal failure induced by renal ischemia or drugs continues to be a relevant clinical problem. Li et al. have demonstrated that proximal tubule-restricted peroxisome proliferator-activated receptor-alpha (PPARalpha) expression in transgenic mice reduced cisplatin- and ischemia/reperfusion-induced acute renal injury. Their article suggests a role for the maintenance of free fatty acid oxidation in the proximal tubule as a mechanism of nephroprotection, as well as a potential clinical utility of PPARalpha activators in the prevention of acute renal failure.
Lopez-Hernandez
Francisco J
FJ
Renal and Cardiovascular Physiopathology Unit, Queen Sofia Institute of Nephrology Research, Department of Physiology and Pharmacology, University of Salamanca, Salamanca 37007, Spain.
Lopez-Novoa
José M
JM
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000503:physiopathology; D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D007687:Kidney Tubules, Proximal / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D010084:Oxidation-Reduction; D047493:PPAR alpha / Q000378:metabolism*; D015427:Reperfusion Injury / Q000235:genetics / Q000378:metabolism*
D005230:Fatty Acids, Nonesterified; D047493:PPAR alpha