Barrett's esophagus: a pre-cancerous condition approach to diagnosis and management.
Barrett's esophagus (BE) results from prolonged uncontrolled gastroesophageal reflux (GERD). Patients at risk for BE should be screened with upper endoscopy. Dysplasia is identified pathologically on endoscopic biopsy. The finding of low grade dysplasia indicates the need for more surveillance. High grade dysplasia warrants intervention with ablative techniques or surgery due to the extremely high rate of malignant transformation to esophageal adenocarcinoma. All patients should receive measures to control GERD (life-style modifications and acid suppression).
Choueiri
Nabil E
NE
Saint Louis University School of Medicine, USA.
Prather
Charlene M
CM
D000368:Aged; D001471:Barrett Esophagus / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D004938:Esophageal Neoplasms / Q000209:etiology / Q000517:prevention & control; D005764:Gastroesophageal Reflux / Q000150:complications / Q000601:surgery; D006801:Humans; D008297:Male; D012307:Risk Factors