title: [Structure-activity relationships of phenylethanoid glycosides in plants of Cistanche salsa on antioxidative activity].
abstract: OBJECTIVE
  To study the structure-activity relationships of phenylethanoid glycosides in plants of Cistanche salsa on antioxidative activity.
  
  
  METHODS
  By the assay systems of DPPH*, the antioxidant activity of six phenylethanoid glycosides from plants of Cistanche salsa was determined to investigate the relationship between the antioxidant activities and phenylethanoid glycosides's structural characteristics.
  
  
  RESULTS
  The antioxidative activity of phenylethanoid glycosides was variant with dose-dependent effect. The sequence of the strength of the antioxidative activity of the six components was shown to be 2'-Acetylacteoside > Acteoside > or = Tubuloside B > or = Isoacteoside > Echinacoside > Cistanoside A.
  
  
  CONCLUSIONS
  The antioxidative activity of phenylethanoid glycosides is related to the number of phenolic hydroxyl, steric hindrance, 2-acetyl on the middle glucopyranose, and the location of phenolic hydroxyl. Additionally, it may be related to the alpha, beta-unsaturated ketone of phenl-2-propenoyl.
authors.affiliation: Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, China. yjh-yft@163.com
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Yang
authors.forename: Jun-Ping
authors.initials: JP
authors.lastname: Hu
authors.forename: Kasimu
authors.initials: K
authors.lastname: Rena
authors.forename: Nian-Sheng
authors.initials: NS
authors.lastname: Du
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D031671:Cistanche / Q000737:chemistry*; D016166:Free Radical Scavengers; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000378:metabolism; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: C111522:2'-acetylacteoside; D000975:Antioxidants; D016166:Free Radical Scavengers; D005960:Glucosides; D006027:Glycosides; D017665:Hydroxyl Radical