title: Is there an adjunctive role of tamsulosin to extracorporeal shockwave lithotripsy for upper ureteric stones: results of an open label randomized nonplacebo controlled study.
abstract: OBJECTIVE
  To investigate the role of tamsulosin as an adjunct to management of upper ureteric stones (UUS) with extracorporeal shock wave lithotripsy (SWL).
  
  
  METHODS
  In this prospective, randomized, open label study, patients with single UUS (for SWL) were randomly assigned into 2 groups based on whether they received 0.4 mg tamsulosin (group A and B, respectively) during treatment. Repeat SWL was performed at week 1, 3, and 5 after first session. Primary outcome variables were success rate and pain intensity.
  
  
  RESULTS
  A total of 40 patients (20 each group) completed the requisite follow-up. Success rate was higher in group A after 1 SWL-session (55% vs 25%, respectively; P = .05). There was an insignificant trend of decreased number of days (30.7 +/- 19.7 vs 39.0 +/- 19.9; P = .19), number of SWL sessions (1.6 vs 2.0; P = .10), and pain experienced (score on visual analog scale, 25.3 +/- 17.9 vs 38.3 +/- 28.0, respectively; P = .41) in group A. Three in group A and 6 in B developed steinstrasse (P = .69). Overall, 1 in group A required auxiliary procedures as compared with 3 in control group (P = .60).
  
  
  CONCLUSIONS
  Tamsulosin improves clearance rate of UUS after single SWL. However, it does not provide significant advantage in terms of decreasing pain associated with this treatment.
authors.affiliation: Department of Urology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India.
authors.forename: Mayank Mohan
authors.initials: MM
authors.lastname: Agarwal
authors.forename: Vineet
authors.initials: V
authors.lastname: Naja
authors.forename: Shrawan K
authors.initials: SK
authors.lastname: Singh
authors.forename: Ravimohan
authors.initials: R
authors.lastname: Mavuduru
authors.forename: Uttam K
authors.initials: UK
authors.lastname: Mete
authors.forename: Santosh
authors.initials: S
authors.lastname: Kumar
authors.forename: Arup K
authors.initials: AK
authors.lastname: Mandal
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000328:Adult; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008096:Lithotripsy; D008297:Male; D011446:Prospective Studies; D013449:Sulfonamides / Q000627:therapeutic use*; D000077409:Tamsulosin; D014514:Ureteral Calculi / Q000188:drug therapy / Q000628:therapy*
chemical_list: D000317:Adrenergic alpha-Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin