The effects of metabolic syndrome and apolipoprotein E4 on cognitive event-related potentials.
To reduce the care burden of dementia, identifying whether the combined effect of metabolic syndrome and epsilon4 increases the risk of cognitive decline needs to be determined. Using the Cognitive Abilities Screening Instrument (CASI), 145 mentally healthy middle-aged and older adults were recruited to investigate the influence of metabolic syndrome and epsilon4 on cognitive event-related potentials (ERPs). The results showed no difference in CASI scores, N100 and P300 measurements and epsilon4 carrier percentage between participants with and without metabolic syndrome. The epsilon4 carriers displayed a significant decrease in P300 amplitude, although the CASI scores and N100 component showed no difference. We conclude that metabolic syndrome exerts little effect on N100 and P300 measurements, and that epsilon4 carrier is an independent predictor of low P300 amplitude.
Lai
Chiou-Lian
CL
Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, #100 Tzyou 1st Road, Kaohsiung, Taiwan, ROC.
Lin
Ruey-Tay
RT
Liou
Li-Min
LM
Hsu
Chung-Yao
CY
Hsieh
Hsin-Yi
HY
Liu
Ching-Kuan
CK
D000161:Acoustic Stimulation / Q000379:methods; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D053327:Apolipoprotein E4 / Q000235:genetics*; D001794:Blood Pressure / Q000502:physiology; D003072:Cognition Disorders / Q000209:etiology* / Q000235:genetics*; D004569:Electroencephalography / Q000379:methods; D018913:Event-Related Potentials, P300 / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism; D008297:Male; D008659:Metabolic Diseases / Q000150:complications* / Q000235:genetics; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology
D053327:Apolipoprotein E4; D008075:Lipoproteins, HDL