title: Sex ratio and pregnancy complications according to mode of conception in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To investigate pregnancy complications and offspring sex ratio according to mode of conception in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Retrospective, descriptive study.
  
  
  METHODS
  Tertiary, university hospital.
  
  
  METHODS
  A total of 176 women with PCOS diagnosed according to the Rotterdam criteria.
  
  
  METHODS
  Women with PCOS who have participated in one or more clinical studies were invited to answer a questionnaire on the mode of conception, pregnancy complications, gestational length and offspring gender. A total of 139 women responded. Data were quality checked against hospital files.
  
  
  METHODS
  Fertility, mode of conception, offspring gender and pregnancy complications.
  
  
  RESULTS
  More than half (54%) of the singleton pregnancies were conceived spontaneously. More complications were seen in pregnancies achieved while using metformin than without (p = 0.02). Compared to spontaneous conception, more boys than girls were born in singleton pregnancies after in vitro fertilization/intracytoplasmatic sperm injection treatment (p = 0.004).
  
  
  CONCLUSIONS
  In women with PCOS the mode of conception may influence both the rate of pregnancy complications and the offspring sex ratio.
authors.affiliation: Department of Obstetrics and Gynecology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. eszter.vanky@ntnu.no
authors.forename: Eszter
authors.initials: E
authors.lastname: Vanky
authors.forename: Bjørn
authors.initials: B
authors.lastname: Backe
authors.forename: Sven M
authors.initials: SM
authors.lastname: Carlsen
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications; D012044:Regression Analysis; D012189:Retrospective Studies; D012744:Sex Ratio; D020554:Sperm Injections, Intracytoplasmic; D011795:Surveys and Questionnaires; D055815:Young Adult