title: Patterns of radiotherapy practice for pancreatic cancer in Japan: results of the Japanese Radiation Oncology Study Group (JROSG) survey.
abstract: OBJECTIVE
  To determine the patterns of radiotherapy practice for pancreatic cancer in Japan.
  
  
  METHODS
  A questionnaire-based national survey of radiotherapy for pancreatic cancer treated between 2000 and 2006 was conducted by the Japanese Radiation Oncology Study Group (JROSG). Detailed information on 870 patients from 34 radiation oncology institutions was accumulated.
  
  
  RESULTS
  The median age of all patients was 64 years (range, 36-88), and 80.2% of the patients had good performance status. More than 85% of patients had clinical Stage T3-T4 disease, and 68.9% of patients had unresectable disease at diagnosis. Concerning radiotherapy (RT), 49.8% of patients were treated with radical external beam RT (EBRT) (median dose, 50.4 Gy), 44.4% of patients were treated with intraoperative RT (median dose, 25 Gy) with or without EBRT (median dose, 45 Gy), and 5.9% of patients were treated with postoperative radiotherapy (median dose, 50 Gy). The treatment field consisted of the primary tumor (bed) only in 55.6% of the patients. Computed tomography-based treatment planning and conformal RT was used in 93.1% and 83.1% of the patients treated with EBRT, respectively. Chemotherapy was used for 691 patients (79.4%; before RT for 66 patients; during RT for 531; and after RT for 364). Gemcitabine was the most frequently used drug, followed by 5-fluorouracil.
  
  
  CONCLUSIONS
  This study describes the general patterns of RT practice for pancreatic cancer in Japan. Most patients had advanced unresectable disease, and radical EBRT, as well as intraoperative RT with or without EBRT, was frequently used. Chemotherapy with gemcitabine was commonly used in conjunction with RT during the survey period.
authors.affiliation: Department of Radiology, University of the Ryukyus, Okinawa, Japan. kogawa@med.u-ryukyu.ac.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ogawa
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Karasawa
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Onishi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kazumoto
authors.forename: Keiko
authors.initials: K
authors.lastname: Shibuya
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shibuya
authors.forename: Yoshishige
authors.initials: Y
authors.lastname: Okuno
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nishino
authors.forename: Etsuyo
authors.initials: E
authors.lastname: Ogo
authors.forename: Nobue
authors.initials: N
authors.lastname: Uchida
authors.forename: Kumiko
authors.initials: K
authors.lastname: Karasawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Nemoto
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Nishimura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000379:methods / Q000706:statistics & numerical data; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D019538:Health Care Surveys; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D010818:Practice Patterns, Physicians'; D018787:Radiation Oncology; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D020266:Radiotherapy, Conformal / Q000706:statistics & numerical data; D000093542:Gemcitabine
chemical_list: D000970:Antineoplastic Agents; D003841:Deoxycytidine; D005472:Fluorouracil; D000093542:Gemcitabine