Pretreatment with l-histidine produces a shift from methamphetamine-induced stereotypical biting to persistent locomotion in mice.
The administration of methamphetamine (METH; 10mg/kg, i.p.) to male ICR mice induced bizarre behaviors including persistent locomotion and stereotypical behaviors, which were classified into four categories: stereotypical head-bobbing, circling, sniffing, and biting. Pretreatment with l-histidine (750 mg/kg, i.p.) significantly decreased the stereotypical biting induced by METH and significantly increased persistent locomotion. This effect of l-histidine on behavior was completely abolished by simultaneous administration of pyrilamine or ketotifen (brain-penetrating histamine H(1) receptor antagonists; 10mg/kg each, i.p.), but not by the administration of fexofenadine (a non-sedating histamine H(1) receptor antagonist that does not cross the blood-brain barrier; 20mg/kg), zolantidine (a brain-penetrating histamine H(2) receptor antagonist; 10mg/kg), thioperamide, or clobenpropit (brain-penetrating histamine H(3) receptor antagonists; 10mg/kg each). The histamine content of the hypothalamus was significantly increased by l-histidine treatment. These data suggest that l-histidine modifies the effects of METH through central histamine H(1) receptors.
Kitanaka
Junichi
J
Department of Pharmacology, Hyogo College of Medicine, Hyogo 663-8501, Japan. kitanaka-hyg@umin.net
Kitanaka
Nobue
N
Tatsuta
Tomohiro
T
Miyoshi
Akio
A
Koumoto
Atena
A
Tanaka
Koh-Ichi
K
Nishiyama
Nobuyoshi
N
Morita
Yoshio
Y
Takemura
Motohiko
M
D000818:Animals; D001733:Bites and Stings; D006632:Histamine / Q000378:metabolism; D006639:Histidine / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D008761:Methylhistamines / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D013239:Stereotyped Behavior / Q000187:drug effects*
D008761:Methylhistamines; D008694:Methamphetamine; D006639:Histidine; D006632:Histamine; C048140:N-methylhistamine