title: The utility of routine D-dimer measurement in syncope.
abstract: OBJECTIVE
  To establish whether D-dimer is an independent predictor of 1-month serious outcome and all-cause death in syncope patients presenting to the emergency department (ED).
  
  
  METHODS
  This was a prospective cohort study of all adults presenting with syncope to an ED in the UK. Plasma D-dimer concentrations were determined in citrated plasma obtained at presentation. The primary endpoint was the combination of serious outcome and all-cause death at 1 month.
  
  
  RESULTS
  Of 237 patients enrolled, 205 patients had a suitable plasma sample and had complete follow-up. Seventeen patients had a serious outcome or death at 1 month including three patients with a pulmonary embolus and eight with a serious cardiovascular outcome. Nearly a half of all patients (n=94; 46%) had a plasma D-dimer concentration above the upper limit of normal, 10 of whom had a serious outcome or death at 1 month. Receiver-operator characteristic curve analysis showed no relationship between plasma D-dimer concentration and serious outcome or death at 1 month. An elevated plasma D-dimer concentration was found in all patients with a pulmonary embolus.
  
  
  CONCLUSIONS
  Plasma D-dimer is frequently raised in patients presenting with syncope to the ED and consequently does not predict 1-month serious outcome or death. We conclude that there is no role for the routine measurement of D-dimer in the management of patients presenting to the ED with syncope.
authors.affiliation: Emergency Department, Royal Infirmary of Edinburgh, Edinburgh, UK
authors.forename: Camilla J
authors.initials: CJ
authors.lastname: Stockley
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Reed
authors.forename: David E
authors.initials: DE
authors.lastname: Newby
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Coull
authors.forename: Gareth R
authors.initials: GR
authors.lastname: Clegg
authors.forename: Alasdair J
authors.initials: AJ
authors.lastname: Gray
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004636:Emergency Service, Hospital; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D012372:ROC Curve; D013575:Syncope / Q000097:blood* / Q000209:etiology; D055815:Young Adult
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D