title: A neurobehavioral intervention and assessment program in very low birth weight infants: outcome at 24 months.
abstract: OBJECTIVE
  To determine whether the Infant Behavioral Assessment and Intervention Program (IBAIP) improves development and behavior in very low birth weight (VLBW) infants at 24-month corrected age.
  
  
  METHODS
  In a multicenter, randomized, controlled trial 86 infants received postdischarge intervention until 6-month corrected age. The intervention consisted of supporting infants' self-regulation and development, and facilitating sensitive parent-infant interactions; 90 control infants received regular care. At 6 months, positive intervention effects were found. At 24 months, development and behavior were evaluated with the Bayley Scales of Infant Development-II (BSID-II) and the Child Behavior Check List (CBCL).
  
  
  RESULTS
  Eighty-three intervention and 78 control infants were available for follow-up. After adjustment for differences in perinatal characteristics, an intervention effect of 6.4 points (+/- standard error, 2.4) on the Psychomotor Developmental Index favored the intervention infants. Groups did not differ on the Mental Developmental Index, the Behavioral Rating Scale of the BSID-II, or on the CBCL. Subgroup analyses revealed improved motor as well as improved mental outcomes in intervention infants with bronchopulmonary dysplasia and with combined biological and social risk factors.
  
  
  CONCLUSIONS
  The IBAIP shows sustained motor improvement in VLBW infants until 2-year corrected age.
authors.affiliation: Department of Rehabilitation, Academic Medical Center, University of Amsterdam, The Netherlands.
authors.forename: Karen
authors.initials: K
authors.lastname: Koldewijn
authors.forename: Aleid
authors.initials: A
authors.lastname: van Wassenaer
authors.forename: Marie-Jeanne
authors.initials: MJ
authors.lastname: Wolf
authors.forename: Dominique
authors.initials: D
authors.lastname: Meijssen
authors.forename: Bregje
authors.initials: B
authors.lastname: Houtzager
authors.forename: Anita
authors.initials: A
authors.lastname: Beelen
authors.forename: Joke
authors.initials: J
authors.lastname: Kok
authors.forename: Frans
authors.initials: F
authors.lastname: Nollet
mesh_terms: D002657:Child Development; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000517:prevention & control*; D018479:Early Intervention, Educational; D005260:Female; D006801:Humans; D018730:Infant Behavior; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D008297:Male; D009460:Neurologic Examination; D012307:Risk Factors; D012959:Socioeconomic Factors; D016896:Treatment Outcome