title: Post-radiation reactive changes in a single vertebral body mimicking metastatic pineoblastoma.
abstract: This 18-year-old woman presented with headache and diplopia over several months and was found to have an enhancing pineal tumor with resultant obstructive hydrocephalus. Following standard preoperative diagnostic tests, including spinal axis imaging, the patient was taken to the operating room for an endoscopic third ventriculostomy to relieve hydrocephalus and then subsequently underwent a craniotomy for gross-total resection of the pineal mass. The patient was discharged after an uneventful hospital course and received standard adjuvant cranial-spinal radiation and chemotherapy as an outpatient. Follow-up imaging 1 year after surgery demonstrated a metabolically active, lytic lesion in the C-3 vertebral body and new lung lesions suggesting a metastatic pineoblastoma. The patient underwent a C-3 anterior corpectomy and reconstruction without complication as aggressive therapy for presumed metastatic disease. Final pathological results from the vertebral lesion were consistent with radiation-induced reactive changes, not metastatic pineoblastoma as originally suspected. The patient recovered well and remains symptom free. To the authors' knowledge this is the first reported case of reactive changes mimicking metastasis in a single vertebral body following standard therapy for resected primary pineoblastoma.
authors.affiliation: Departments of Neurological Surgery, University of California San Francisco, California, USA.
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Tate
authors.forename: Anurahda
authors.initials: A
authors.lastname: Banerjee
authors.forename: Scott R
authors.initials: SR
authors.lastname: Vandenberg
authors.forename: Tarik
authors.initials: T
authors.lastname: Tihan
authors.forename: John H
authors.initials: JH
authors.lastname: Chi
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Ames
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Parsa
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D003399:Craniotomy; D004172:Diplopia / Q000209:etiology; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000150:complications; D008279:Magnetic Resonance Imaging; D019635:Neurosurgical Procedures; D010870:Pineal Gland / Q000473:pathology* / Q000601:surgery; D010871:Pinealoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D011878:Radiotherapy / Q000009:adverse effects*; D013131:Spine / Q000473:pathology* / Q000528:radiation effects* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014696:Ventriculostomy