THE APPLICATION OF QUANTUM MECHANICS TO CERTAIN CASES OF HOMOGENEOUS CATALYSIS. I.
1. The activation energy for the hydrolytic breaking of a peptid linkage has been calculated from quantum mechanical considerations. 2. The relative catalytic effects of H(+) and OH(-) and the mechanism of these effects have been calculated and discussed. 3. These effects are both qualitatively and semiquantitatively in agreement with experiment.
Stearn
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Division of Physical Chemistry, University of Missouri, Columbia.