A simple and convenient method for the synthesis of pyranoid glycals.
A simple, mild, and environmentally benign synthesis procedure of pyranoid glycals is described. In a novel fashion, protected glycopyranosyl bromides undergo the reductive elimination in the presence of zinc in phosphate buffer at room temperature. The pyranoid glycals were obtained in good-to-excellent yields (18 examples).
Zhao
Jinzhong
J
Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; Shanxi Agriculture University, Taigu Shanxi 030801, China.
Wei
Shanqiao
S
Ma
Xiaofeng
X
Shao
Huawu
H
D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry*; D055772:Green Chemistry Technology; D010084:Oxidation-Reduction; D010710:Phosphates / Q000737:chemistry; D013696:Temperature; D015032:Zinc / Q000737:chemistry
D002241:Carbohydrates; D010710:Phosphates; D015032:Zinc