IMPAIRMENT OF ANTIBODY RESPONSE IN PYRIDOXINE-DEFICIENT RATS.
Striking impairment of the antibody response to sheep erythrocytes was found in pyridoxine-deficient rats. Deficiencies in the three other B factors required by the rat, and low protein feeding, having effects on body weight comparable to pyridoxine deficiency, failed to influence the antibody response studied. Confirming previous observations, a striking loss of thymic and lymphoid tissue occurred in the pyridoxine-deficient animals. A marked deficit in thymus weight also resulted from the feeding of a diet low in thiamin. Histologically, however, lymphoid atrophy was less pronounced in thiamin-deficient rats than in those deprived of pyridoxine.
Stoerk
H C
HC
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York.
Eisen
H N
HN
John
H M
HM
D000818:Animals; D000906:Antibodies; D000917:Antibody Formation; D000941:Antigens; D001835:Body Weight; D007109:Immunity; D011736:Pyridoxine; D012756:Sheep; D026681:Vitamin B 6 Deficiency
D000906:Antibodies; D000941:Antigens; D011736:Pyridoxine