title: [Progress of research in osteoarthritis. Recent advance in the study of susceptibility genes for osteoarthritis].
abstract: Osteoarthritis (OA) is a polygenic disease based on genetic and environmental factors. Identification of its genetic factor, i.e., the susceptibility genes for OA is rapidly in progress. Recent advance in the study of OA susceptibility genes is reviewed with focus on the genome-wide association study and the large-scale replication study.
authors.affiliation: Laboratory for Bone and Joint Diseases, Center for Genomic Medicine, RIKEN.
authors.forename: Shiro
authors.initials: S
authors.lastname: Ikegawa
mesh_terms: D015331:Cohort Studies; D024142:Collagen Type VI; D051546:Cyclooxygenase 2; D016326:Extracellular Matrix Proteins; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015894:Genome, Human / Q000235:genetics*; D023281:Genomics; D006023:Glycoproteins; D055428:Growth Differentiation Factor 5; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D010003:Osteoarthritis / Q000453:epidemiology / Q000235:genetics*; D011544:Pseudogenes; D000099274:Frizzled-Related Proteins
chemical_list: D024142:Collagen Type VI; D051546:Cyclooxygenase 2; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D055428:Growth Differentiation Factor 5; D047908:Intracellular Signaling Peptides and Proteins; D000099274:Frizzled-Related Proteins; C439889:ASPN protein, human; C531065:COL6A4P1 protein, human; C525893:GDF5 protein, human; C496540:PTGS2 protein, human