title: Reassortment between amantadine-resistant and -sensitive H1N1 influenza A viruses generated an amantadine-sensitive virus during the 2007-2008 season.
abstract: The frequency of the amantadine-resistant H1N1 influenza A virus has been increasing since the 2005-2006 season. It is unclear whether reassortment was involved in this trend. Here, we show that cocirculation of amantadine-resistant and -sensitive strains led to the genesis of amantadine-sensitive reassortant virus during the 2007-2008 season. Thereafter, the reassortant virus predominated. This contrasts with the trend for the H3N2 virus, in which the amantadine-resistant reassortant virus became predominant. The results suggest that it is necessary to monitor genome dynamics to understand the evolution and mechanism of the emergence and spread of antiviral resistance among influenza A viruses.
authors.affiliation: Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Furuse
authors.forename: Akira
authors.initials: A
authors.lastname: Suzuki
authors.forename: Midori
authors.initials: M
authors.lastname: Shimizu
authors.forename: Makiko
authors.initials: M
authors.lastname: Kishi
authors.forename: Rumi
authors.initials: R
authors.lastname: Sawayama
authors.forename: Mariko
authors.initials: M
authors.lastname: Saito
authors.forename: Naoko
authors.initials: N
authors.lastname: Fuji
authors.forename: Nao
authors.initials: N
authors.lastname: Nukiwa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Oshitani
mesh_terms: D000547:Amantadine / Q000627:therapeutic use*; D024882:Drug Resistance, Viral; D019143:Evolution, Molecular; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics*; D053122:Influenza A Virus, H3N2 Subtype / Q000235:genetics; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology*; D009305:Nasopharynx / Q000821:virology; D010802:Phylogeny; D016865:Reassortant Viruses / Q000235:genetics*; D014776:Virus Cultivation
chemical_list: D000547:Amantadine