[Application of total nutrient admixture in acute hepatic failure rats].
OBJECTIVE
To study the therapeutic efficacy of total nutrition admixture (TNA) containing 30.6% BCAA, MCT/LCT, glucose, vitamin, electrolytes in rat with acute hepatic failure (AHF).


METHODS
30 Wistar rats were randomly divided into 4 groups: Normal control, AHF control, Fat-free nutrient admixture group, TNA group. AHF model was induced by D-galactosamine Liver and renal function, nitrogen balance, plasma total protein, albumin, prealbumin, fibronectin, hemoglobin, aminogram, tumor necrosis factor, lymphocyte transformation rate, glucose, blood fat tests etc were determined.


RESULTS
The improvement of liver and renal function was better in TNA group than those in other groups. ALT ALP TBil BUN were lower in TNA group than those in other groups. TP, ALB, PA, N-balance in TNA group were significantly higher than those in other groups. The spectrum of plasma amino acids of the TNA group was close to the normal and the control group. The TNF in TNA group were significantly higher than that in Fat-free nutrient admixture group. The stimulation index in TNA group was significantly higher than that in other groups. The difference of triglyceride in TNA group and normal diet was statistically significant, The difference of cholesterol in TNA group and Fat-free nutrient admixture was statistically significant, The difference of lipid peroxidation in four groups was not statistically significant.


CONCLUSIONS
Nutritional supportive treatment is necessary for AHF.
Qi
Yu-Mei
YM
Department of Nutrition, Tianjin Third Central Hospital, Tianjin 300170, China. qym0305@yahoo.com.cn
Zhang
Ming
M
Chen
Ya-Jun
YJ
Xu
Jin
J
Yang
Hui
H
D000704:Analysis of Variance; D000818:Animals; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D004338:Drug Combinations; D005217:Fat Emulsions, Intravenous / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D005685:Galactans; D008055:Lipids / Q000032:analysis / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000378:metabolism / Q000628:therapy*; D008111:Liver Function Tests; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D010289:Parenteral Nutrition, Total; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D015415:Biomarkers; D004338:Drug Combinations; D005217:Fat Emulsions, Intravenous; D005685:Galactans; D008055:Lipids; D009584:Nitrogen