Urinary NT-proBNP. A valuable marker in the assessment of patients with essential hypertension.
The aim was to evaluate the usefulness of urinary N-terminal fragment of B-type natriuretic peptide (NT-proBNP) measurement for predicting the presence of left ventricular hypertrophy (LVH) in 160 asymptomatic patients with essential hypertension. The urinary NT-proBNP/creatinine ratio was higher in patients with LVH than in either those without LVH (P< .0001) or control subjects (P< .0001). Multivariate linear regression analysis identified age (P=.034), left ventricular mass index (P=.026) and serum NT-proBNP level (P=.001) as predictors of the urinary peptide level. The area under the curve for the NT-proBNP/creatinine ratio was 0.71+/-0.04 (P< .0001) for identifying LVH. Logistic regression analysis showed that the NT-proBNP: creatinine ratio was a predictor of LVH (odds ratio=4.074; P=.009). In conclusion, the urinary NT-proBNP concentration is a new marker that could be useful for identifying LVH in subjects with essential hypertension.
Roselló-Lletí
Esther
E
Centro de Investigación del Hospital Universitario La Fe, Valencia, Spain.
Rivera
Miguel
M
Cortés
Raquel
R
Grigorian
Lilian
L
Miró
Vicente
V
Soria
Federico
F
Portolés
Manuel
M
Bertomeu
Vicente
V
D000368:Aged; D015415:Biomarkers / Q000652:urine*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000652:urine*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000652:urine*; D010446:Peptide Fragments / Q000652:urine*
D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain