Agreement between glucose trends derived from three simultaneously worn continuous glucose sensors.
BACKGROUND
Sensors detect the rate and direction of glucose trend. They need to be accurate and reproducible as could be evidenced by strong agreement between multiple sensors. We evaluated this relationship through simultaneously worn glucose sensors using several methods of slope analysis.


METHODS
Ten type 1 diabetic, insulin pump-treated subjects were studied while simultaneously wearing three CGMS Gold sensors each. Sensors were placed in the right abdomen (reference), left abdomen, and left upper arm. Sensors were calibrated and chronologically aligned. Data were only interpreted and included if there were 24 hours of data simultaneously obtained from all three sensors.


RESULTS
Using a two-point derived slope, increasing the duration of the trend from 5 to 60 minutes improved agreement between sensors. Using a 20-minute rolling average trend (using every 5-minute glucose value during the 20 minutes) improved the agreement to 94.3%. Finally, using whichever of the two comparator sensor rolling average trends was closest to the reference (better of two), the agreement improved to 98.2%. However, for these trend analysis methods, when the absolute reference rate of change was more than 1 mg/dl/min, the agreement decreased. Even with the best analysis approach, at an absolute reference sensor rate of change of >2 mg/dl/min, the agreement between sensors was only 40.0%.


CONCLUSIONS
Despite several methods of analysis, trend agreement from multiple sensors diminishes as the absolute rate of change of reference glucose increases.
B King
Allen
A
Diabetes Care Center, Salinas, California 93901, USA. aking@diabetescarecenter.com
Armstrong
Dana
D
Chu
Caroline
C
Sharma
Manoj
M
Price
David
D