title: Effects of different suture materials on wound healing and infection in subcutaneous closure techniques.
abstract: BACKGROUND
  In this study we aimed to investigate the effects of different suture materials on wound healing and infection in subcutaneous closure techniques.
  
  
  METHODS
  Twenty-nine rats were randomly allocated to 5 groups. All subjects received 2-cm vertical dermal and subdermal incisions on their backs under sterile and proper surgical conditions. The subdermal cuts were then closed with vicryl (polyglycolic acid), biosyn (monofilament glycomer), prolene (polypropylene) and tissue adhesive (2-octylcyanoacrylate). After 10 days, all sutured areas were examined for seroma, haematoma formation and cosmetic outcome. The incisional lines were excised with 1-cm-wide skin strips and tissue hydroxyproline levels were determined. The specimens obtained were evaluated for the presence of giant cells, mononuclear cells, fibrosis and neutrophils.
  
  
  RESULTS
  No differences in tissue hydroxyproline levels were found between any of the suture materials used. Fibrotic process and inflammatory cell infiltration were more prominent in the biosyn and prolene groups than in other groups. Foreign body giant cells were observed in the biosyn group.
  
  
  CONCLUSIONS
  Vicryl and tissue adhesive should be preferred in subcutaneous closure techniques.
authors.affiliation: Department of Paediatric Surgery, Gazi University, Faculty of Medicine, Ankara, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Sönmez
authors.forename: B
authors.initials: B
authors.lastname: Bahar
authors.forename: R
authors.initials: R
authors.lastname: Karabulut
authors.forename: O
authors.initials: O
authors.lastname: Gülbahar
authors.forename: A
authors.initials: A
authors.lastname: Poyraz
authors.forename: Z
authors.initials: Z
authors.lastname: Türkyilmaz
authors.forename: B
authors.initials: B
authors.lastname: Sancak
authors.forename: A C
authors.initials: AC
authors.lastname: Başaklar
mesh_terms: D000818:Animals; D003487:Cyanoacrylates / Q000627:therapeutic use; D005549:Foreign-Body Reaction / Q000453:epidemiology; D011098:Polyglactin 910; D011126:Polypropylenes; D051381:Rats; D017208:Rats, Wistar; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control; D013537:Sutures; D014014:Tissue Adhesives / Q000627:therapeutic use; D014945:Wound Healing
chemical_list: D003487:Cyanoacrylates; D011126:Polypropylenes; D014014:Tissue Adhesives; D011098:Polyglactin 910; C100832:octyl 2-cyanoacrylate