Association between adiponectin, resistin, insulin resistance, and colorectal tumors.
OBJECTIVE
In this study, we have examined the correlation between colorectal cancer (CRC) and serum adiponectin and resistin levels, body mass index and insulin resistance.


METHODS
The relation between serum adiponectin and resistin levels, obesity and insulin resistance in 36 CRC patients and 37 controls was examined.


RESULTS
Insulin and homeostasis model assessment insulin resistance index (HOMA-IR) levels were higher, and adiponectin levels were significantly decreased in patients versus controls, whereas, resistin levels were significantly increased. A negative correlation between adiponectin, HOMA-IR, and insulin and a positive correlation between HOMA-IR, insulin, and stage were detected. There was no correlation between the stage and resistin. Adiponectin level negatively correlated with the stage. Adiponectin and resistin could play a role in colon cancer carcinogenesis, and adiponectin could be responsible for poor prognosis in colorectal cancer.
Gonullu
Guzin
G
Department of Medical Oncology, Ondokuz Mayis University Medical School, Kurupelit, 55139 Samsun, Turkey. ggonullu@omu.edu.tr
Kahraman
Hakki
H
Bedir
Abdulkerim
A
Bektas
Ahmet
A
Yücel
Idris
I
D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D052243:Resistin / Q000097:blood*
C499918:ADIPOQ protein, human; D052242:Adiponectin; C499624:RETN protein, human; D052243:Resistin