title: [CTX-M-15-producing Klebsiella pneumoniae: a change in the epidemiology of ESBL].
abstract: Klebsiella pneumoniae is frequently involved in nosocomial outbreaks worldwide. High level of resistance is common for these bacteria leading to reduce antibiotic treatments and prolonged hospital stay for patients. Resistance determinants are often located on plasmids. During the 1980-1990s, ESBL encoding genes belonged to the TEM and SHV type. From the early 2000s, a new trend was observed with ESBL of the CTX-M type being increasingly described in K. pneumoniae, and more particularly CTX-M-15.
authors.affiliation: Inserm U914, Emerging Resistance to Antibiotics, Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique–Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 78 rue du Général-Leclerc, 94275 Le Kremlin Bicêtre, France. amelie.carrer@bct.aphp.fr
authors.forename: A
authors.initials: A
authors.lastname: Carrër
authors.forename: P
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D005075:Biological Evolution; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology / Q000635:transmission; D004196:Disease Outbreaks / Q000706:statistics & numerical data; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D005843:Geography; D014943:Global Health / Q000639:trends; D006801:Humans; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000235:genetics / Q000382:microbiology / Q000635:transmission; D007711:Klebsiella pneumoniae / Q000145:classification* / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity; D001618:beta-Lactamases / Q000145:classification* / Q000235:genetics / Q000378:metabolism
chemical_list: C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases