The role of endothelin-1 and its correlation with CA125 levels, grayscale ultrasonography and doppler findings in differential diagnoses of ovarian tumors.
OBJECTIVE
Assessment of endothelin-1 (ET-1) level for the differential diagnosis of ovarian tumors was performed.


METHODS
Fifty-three women with ovarian tumors (12 malignant, 41 benign) treated at the Division of Gynecological Surgery, Poznan, Poland were analyzed. ET-1 serum levels were compared with CA125 and Doppler parameters (RI, PI, PSV). The differences were evaluated using the unpaired t-test with Welch's correction (p < 0.05).


RESULTS
There was statistically significant difference in ET-1 levels between the ovarian cancer and benign tumor groups (3.130 pg/ml and 1.819 pg/ml, respectively). The ROC area for ET-1 and CA125 were 0.727 and 0.791, respectively. A negative linear correlation between the level of ET-1 and RI and a positive linear correlation between the level of ET-1 and PSV in the ovarian cancer group were found.


CONCLUSIONS
ET-1 as a new biomarker for predicting ovarian cancer is not satisfying. A correlation between ET-1 levels and Doppler parameters is very interesting and its role in angiogenesis should be studied extensively.
Moszynski
R
R
Division of Gynecological Surgery, Department of Gynecology, Obstetrics and Gynecological Oncology, University of Medical Sciences, Poznan, Poland. kgo@gpsk.am.poznan.pl
Szpurek
D
D
Michalak
S
S
Szubert
S
S
Sajdak
S
S
D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D018450:Disease Progression; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging* / Q000473:pathology; D012372:ROC Curve; D018608:Ultrasonography, Doppler
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D019332:Endothelin-1