title: Case of cutaneous malignant melanoma surviving 16 years with late recurrence.
abstract: Late recurrence, defined as that occurring 10 or more years after diagnosis, is an unusual event in cutaneous malignant melanoma (MM). A 59-year-old woman presented with a black nodule measuring 10 mm x 9 mm on the sole of her right foot. She was diagnosed with MM and the tumor was totally excised with 5 cm of the normal surrounding skin. Eleven years after the operation, five in-transit metastases were found in her right limb. They were all excised and beta-interferon (IFN-beta) was injected into the skin around the postoperative scars. However, numerous new in-transit skin metastases have been emerging every year in her right limb. Fifty-four in-transit skin metastases have so far been found. Recently, there have been few in-transit metastases. All in-transit metastatic lesions were excised and local IFN-beta injections were conducted continuously. There is no evidence of metastases to the internal organs or lymph nodes. This report describes this case with a brief review of the published work concerning the rare late recurrences of MM.
authors.affiliation: Department of Dermatology, Osaka Medical College, Takatsuki City, Osaka, Japan. der006@poh.osaka-med.ac.jp
authors.forename: Utako
authors.initials: U
authors.lastname: Otsu
authors.forename: Nao
authors.initials: N
authors.lastname: Fukui
authors.forename: Mariko
authors.initials: M
authors.lastname: Iki
authors.forename: Shinichi
authors.initials: S
authors.lastname: Moriwaki
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Kiyokane
mesh_terms: D001707:Biopsy, Needle; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D005528:Foot / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D015552:Injections, Intralesional; D007372:Interferons / Q000008:administration & dosage*; D007564:Japan; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D049268:Positron-Emission Tomography; D021701:Sentinel Lymph Node Biopsy; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery; D013514:Surgical Procedures, Operative / Q000379:methods; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D007372:Interferons