[EPR study of the influence of hypoxia on nitric oxide formation in the blood of Krushinskii-Molodkina rats].
The influence of hypoxia on nitric oxide formation in the blood of Krushinskii-Molodkina rats has been studied by electron paramagnetic resonance. It was found that nitric oxide synthesis in Krushinskii-Molodkina rats is increased compared with that in Wistar rats. A significant enhancement of the EPR signal of Hb-NO complexes in the animal blood was observed after hypoxia simulating the altitude of 5000 m above the sea level, in particular in the presence of sodium nitrite and the NO-synthase inhibitor L-nitroarginine. It was assumed that NO synthesis and nitro-/nitrite- reductase systems are activated under hypoxic conditions.
Baĭder
L M
LM
Reutov
V P
VP
Krushinskiĭ
A L
AL
Kuzenkov
V S
VS
Sorokina
E G
EG
Koshelev
V B
VB
Fadiukov
O E
OE
Zhymabaeva
T T
TT
Lozinova
T A
TA
Komissarova
L Kh
LKh
Pinelis
V G
VG
Kositsin
N S
NS
Kuropteva
Z V
ZV
D000818:Animals; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D006454:Hemoglobins / Q000032:analysis / Q000378:metabolism*; D000860:Hypoxia / Q000097:blood*; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
D006454:Hemoglobins; D009569:Nitric Oxide