title: Synthesis, single-crystal characterization and preliminary biological evaluation of novel ferrocenyl pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives.
abstract: A series of novel ferrocenyl pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives was synthesized and characterized by 1H NMR, 13C NMR, IR, HRMS and X-ray diffraction analysis. Preliminary evaluation of biological applications showed that the compounds 6c and 6f inhibit the growth of A549 cells in dosage-dependent manners through cell cycle arrest.
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Xie
authors.forename: Hong-Ling
authors.initials: HL
authors.lastname: Zhao
authors.forename: Hua
authors.initials: H
authors.lastname: Su
authors.forename: Bao-Xiang
authors.initials: BX
authors.lastname: Zhao
authors.forename: Jin-Ting
authors.initials: JT
authors.lastname: Liu
authors.forename: Ji-Kun
authors.initials: JK
authors.lastname: Li
authors.forename: Hong-Shui
authors.initials: HS
authors.lastname: Lv
authors.forename: Bai-Shan
authors.initials: BS
authors.lastname: Wang
authors.forename: Dong-Soo
authors.initials: DS
authors.lastname: Shin
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Miao
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011719:Pyrazines