Synthesis and biological evaluation of dehydroabietic acid derivatives.
A series of C18-oxygenated derivatives of dehydroabietic acid were synthesized from commercial abietic acid and evaluated for their cytotoxic, antimycotic, and antiviral activities.
González
Miguel A
MA
Departamento de Química Orgánica, Universidad de Valencia, E-46100 Burjassot, Valencia, Spain. miguel.a.gonzalez@uv.es
Pérez-Guaita
David
D
Correa-Royero
Julieth
J
Zapata
Bibiana
B
Agudelo
Lee
L
Mesa-Arango
Ana
A
Betancur-Galvis
Liliana
L
D045784:Abietanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D005658:Fungi / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests
D045784:Abietanes; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; C013913:dehydroabietic acid; C023710:abietic acid