Analysis of hyaluronic acid concentration in rat vocal folds during estral and gravidic puerperal cycles.
Hormone plays an important role in the larynx. Among other substances, vocal folds contain hyaluronic acid, which tissue concentration may vary according to hormone action.


OBJECTIVE
the objective of this study is to analyze hyaluronic acid concentration in the vocal folds during estral and gravidic-puerperal cycles.


METHODS
Experimental study. 40 adult rats were divided into two groups. In the first group we used 20 rats to establish the concentration of hyaluronic acid during the estral cycle and in the second group, 20 animals were submitted to the same procedure but during the gravidic-puerperal cycle.


RESULTS
Variations in hyaluronic acid concentration was not observed during the estral cycle. In the gravidic puerperal cycle group, an increase in hyaluronic acid concentration was observed in the puerperal subgroup. Comparing the two groups of estral and gravidic-puerperal cycles, no difference was observed.


CONCLUSIONS
In comparing all subgroups of estral and gravidic-puerperal cycles, an increase in hyaluronic acid concentration was noticed only in the puerperal phase.
Pedroso
José Eduardo de Sá
JE
Outpatient Clinic of Larynx and Voice, UNIFESP-EPM.
Brasil
Osíris Camponês do
OC
Martins
João Roberto Maciel
JR
Nader
Helena Bociane
HB
Simões
Manuel de Jesus
Mde J
D000818:Animals; D030762:Estrous Cycle / Q000378:metabolism*; D005260:Female; D006820:Hyaluronic Acid / Q000032:analysis*; D049590:Postpartum Period / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D014827:Vocal Cords / Q000737:chemistry*
D006820:Hyaluronic Acid