Stress-protective and stress-potentiating effects of antibodies to glutamate and gamma-aminobutyric acid after intranasal administration in C57Bl/6 mice.
We studied the effects of antibodies to glutamate and GABA administered intranasally 1 h before and immediately after stress on the development of stress response in C57Bl/6 mice. Antibodies to glutamate administered 1 h before stress prevented the development of the stress-reaction judging from behavioral parameters in the open field test and hyperalgesia test, while antibodies to GABA potentiated the severity of stress-induced behavioral disorders: total behavioral activity in the open field decreased significantly. When administered after stress, antibodies to glutamate did not reduce, but exacerbated stress reaction; antibodies to GABA also exhibited a stress-potentiating effect.
Yevseyev
V A
VA
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
Zaharova
I A
IA
Vetrile
L A
LA
D000280:Administration, Inhalation; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage* / Q000276:immunology; D001522:Behavior, Animal; D018698:Glutamic Acid / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013312:Stress, Physiological; D005680:gamma-Aminobutyric Acid / Q000276:immunology*
D000906:Antibodies; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid