title: Influence of neodymium:YAG laser capsulotomy on ocular wavefront aberrations in pseudophakic eyes with hydrophilic and hydrophobic intraocular lenses.
abstract: OBJECTIVE
  To study the influence of neodymium:YAG (Nd:YAG) laser capsulotomy on ocular wavefront aberrations.
  
  
  METHODS
  Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium.
  
  
  METHODS
  The wavefront aberrations in pseudophakic eyes with posterior capsule opacification (PCO) were measured with an iTrace aberrometer before and after Nd:YAG laser capsulotomy. These results were analyzed using Zernike coefficients, the total and higher-order root-mean-square (RMS) values, and the wavefront peak-valley difference. In addition, a separate evaluation was performed of 2 intraocular lens (IOL) types: the hydrophilic 92S (hydrophilic IOL subgroup) and the hydrophobic AcrySof SA60AT (hydrophobic IOL subgroup).
  
  
  RESULTS
  The study evaluated 62 pseudophakic eyes (56 patients). The RMS values in all eyes decreased significantly after Nd:YAG laser capsulotomy; the mean decrease in total RMS was 0.186 microm +/- 0.445 (SD) and in higher-order RMS, 0.138 +/- 0.223 microm. The decrease in total RMS (mean 0.325 +/- 0.372 microm) was significant in the hydrophobic IOL subgroup (n = 14) but not in the hydrophilic IOL subgroup. Before capsulotomy, there was a statistically significant difference between the 2 subgroups in the higher-order astigmatism coefficient C(4,-2). After laser capsulotomy, the difference was significantly less.
  
  
  CONCLUSIONS
  Neodymium:YAG laser capsulotomy significantly reduced the wavefront RMS in the hydrophobic IOL subgroup but not in the hydrophilic IOL subgroup. The difference in the wavefront before capsulotomy may originate from a difference in the healing response of the capsular bag between the 2 IOL types.
authors.affiliation: Department of Ophthalmology, Antwerp University Hospital, Faculty of Medicine, Antwerp University, Edegem, Belgium. jos.rozema@uza.be
authors.forename: Jos J
authors.initials: JJ
authors.lastname: Rozema
authors.forename: Carina
authors.initials: C
authors.lastname: Koppen
authors.forename: Veva
authors.initials: V
authors.lastname: de Groot
authors.forename: Marie-José
authors.initials: MJ
authors.lastname: Tassignon
mesh_terms: D000368:Aged; D057108:Corneal Wavefront Aberration / Q000503:physiopathology*; D005260:Female; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D053685:Laser Therapy; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D007903:Lens Capsule, Crystalline / Q000473:pathology / Q000601:surgery*; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D011183:Postoperative Complications; D011446:Prospective Studies; D019591:Pseudophakia / Q000503:physiopathology*