title: Haematological deficiencies in patients with recurrent aphthosis.
abstract: BACKGROUND
  Recurrent aphthosis is a common oral ulcerative condition consisting also of a subset of similar ulcers, properly named 'aphthous-like' ulcers (ALU), linked to systemic diseases and among these, to iron, folic acid and vitamin B(12) deficiencies.
  
  
  OBJECTIVE
  The main objectives of this study were: (i) to evaluate the association between recurrent aphthosis and the most common predisposing factors; (ii) to assess the frequency of ALU in recurrent aphthosis; (iii) to verify the efficacy of a replacement therapy in all ALU patients.
  
  
  METHODS
  Thirty-two adults with recurrent aphthosis and 29 otherwise healthy controls were consecutively recruited, interviewed and subjected to haematological investigations.
  
  
  RESULTS
  Family history of recurrent aphthosis was significantly associated (P < 0.01). The overall frequency of haematinic deficiencies was 56.2% in recurrent aphthosis patients vs. 7% in controls (P < 0.0001). All ALU patients with a negative family history showed a complete remission of the ulcerative episodes after replacement therapy, while those with a positive family history only had a reduction in frequency and severity. In the logistic regression model, only family history was associated with recurrent aphthosis (P = 0.0137).
  
  
  CONCLUSIONS
  The strong association with familiarity, the unexpected higher frequency of ALU (compared with the idiopathic variant) and the good response to replacement therapy means that familiarity should always be investigated. Furthermore, routine haematological screening and tests for serum iron, folic acid and vitamin B(12) deficiencies should be assessed in all patients with recurrent aphthosis to treat any nutritional deficiency and to prevent more important related systemic manifestations.
authors.affiliation: Unit of Oral Medicine, Department Oral Sciences, University Hospital of Palermo, Palermo, Italy. compilato@odonto.unipa.it
authors.forename: D
authors.initials: D
authors.lastname: Compilato
authors.forename: A
authors.initials: A
authors.lastname: Carroccio
authors.forename: F
authors.initials: F
authors.lastname: Calvino
authors.forename: G
authors.initials: G
authors.lastname: Di Fede
authors.forename: G
authors.initials: G
authors.lastname: Campisi
mesh_terms: D000328:Adult; D000368:Aged; D018798:Anemia, Iron-Deficiency / Q000150:complications* / Q000188:drug therapy; D016022:Case-Control Studies; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D005494:Folic Acid Deficiency / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007501:Iron / Q000627:therapeutic use; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012008:Recurrence; D012802:Sicily; D013281:Stomatitis, Aphthous / Q000453:epidemiology* / Q000517:prevention & control; D016896:Treatment Outcome; D014805:Vitamin B 12 / Q000627:therapeutic use; D014806:Vitamin B 12 Deficiency / Q000150:complications* / Q000188:drug therapy
chemical_list: D005492:Folic Acid; D007501:Iron; D014805:Vitamin B 12