Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population.
Alpha-synuclein gene (SNCA) mutations cause familial Parkinsonism but the role of SNCA variability in idiopathic Parkinson's disease (PD) remains incompletely defined. We report a study of SNCA genetic variation in 452 idiopathic PD cases and 245 controls. SNCA copy number mutations were not associated with early-onset disease in this population. The minor allele "G" at rs356165 was associated with increased odds of PD (P = 0.013) and genetic variation in D4S3481 (Rep1) was associated with age of disease onset (P = 0.007). There was a trend toward association between variation at rs2583988 and rapid PD progression.
Rajput
Alex
A
Division of Neurology, University of Saskatchewan and Saskatoon Health Region, Saskatoon, Saskatchewan, Canada.
Vilariño-Güell
Carles
C
Rajput
Michele L
ML
Ross
Owen A
OA
Soto-Ortolaza
Alexandra I
AI
Lincoln
Sarah J
SJ
Cobb
Stephanie A
SA
Heckman
Michael G
MG
Farrer
Matthew J
MJ
Rajput
Ali
A
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D016017:Odds Ratio; D010300:Parkinson Disease / Q000235:genetics*; D012525:Saskatchewan / Q000453:epidemiology / Q000208:ethnology; D051844:alpha-Synuclein / Q000235:genetics*
D051844:alpha-Synuclein