title: No association between transmembrane protein-tyrosine-phosphatase receptor type C (CD45) exon A 77C>G transversion and Hashimoto's thyroiditis in a German population.
abstract: The CD45 77C>G transversion (rs17612648) in exon A of the CD45 gene has been reported to be associated with the development of various autoimmune diseases. Because Hashimoto's thyroiditis (HT) is a typical autoimmune disease, we performed a study to determine the association of the 77C>G transversion with susceptibility to HT. We enrolled 170 patients and 230 healthy individuals in the study. The 77C>G transversion was genotyped by polymerase chain reaction-allele specific restriction enzyme analysis (PCR-ASRA). We found four patients and six control individuals who carried the 77C>G transversion in a heterozygous form. No homozygous individual was detected in patients with HT or control population. The frequency of the 77G allele in patients was 1.2%, which did not significantly differ from 1.3% in controls (p = 0.871). Our data did not reveal any association between CD45 77C>G transversion and susceptibility to HT in a German population.
authors.affiliation: University Clinic Hamburg-Eppendorf, Transplantation Centre, Department of Hepatobiliary and Transplant Surgery, Hamburg, Germany. h.thude@uke.de
authors.forename: H
authors.initials: H
authors.lastname: Thude
authors.forename: S
authors.initials: S
authors.lastname: Weissenborn
authors.forename: C
authors.initials: C
authors.lastname: Vilser
authors.forename: U A
authors.initials: UA
authors.lastname: Müller
authors.forename: C
authors.initials: C
authors.lastname: Kloos
authors.forename: G
authors.initials: G
authors.lastname: Wolf
authors.forename: J
authors.initials: J
authors.lastname: Beck
authors.forename: D
authors.initials: D
authors.lastname: Barz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005091:Exons; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005858:Germany; D050031:Hashimoto Disease / Q000235:genetics*; D006801:Humans; D017493:Leukocyte Common Antigens / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human