Drugging the heat shock factor 1 pathway: exploitation of the critical cancer cell dependence on the guardian of the proteome.
de Billy
Emmanuel
E
Powers
Marissa V
MV
Smith
Jennifer R
JR
Workman
Paul
P
D000818:Animals; D045744:Cell Line, Tumor; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D050884:HSP72 Heat-Shock Proteins / Q000378:metabolism; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism; D000076249:Heat Shock Transcription Factors; D051379:Mice; D010766:Phosphorylation; D011485:Protein Binding; D020543:Proteome / Q000378:metabolism*; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000378:metabolism*
D004268:DNA-Binding Proteins; D050884:HSP72 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; D000076249:Heat Shock Transcription Factors; D020543:Proteome; D014157:Transcription Factors