title: CD57+ T lymphocytes and functional immune deficiency.
abstract: CD57(+) expression in T lymphocytes has been recognized for decades as a marker of in vitro replicative senescence. In recent years, accumulating evidences have pointed on the utility of this marker to measure functional immune deficiency in patients with autoimmune disease, infectious diseases, and cancers. We review here the relevant literature and implications in clinical settings.
authors.affiliation: Division of Hematology, Azienda Ospedaliera Santa Chiara, University of Pisa, via Roma, Pisa, Italy. dfocosi@tin.it
authors.forename: Daniele
authors.initials: D
authors.lastname: Focosi
authors.forename: Marco
authors.initials: M
authors.lastname: Bestagno
authors.forename: Oscar
authors.initials: O
authors.lastname: Burrone
authors.forename: Mario
authors.initials: M
authors.lastname: Petrini
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D015415:Biomarkers; D018959:CD57 Antigens / Q000032:analysis*; D018414:CD8-Positive T-Lymphocytes / Q000737:chemistry / Q000276:immunology* / Q000473:pathology; D016922:Cellular Senescence / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007239:Infections / Q000276:immunology* / Q000473:pathology; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000737:chemistry / Q000276:immunology* / Q000473:pathology; D014181:Transplantation Immunology; D014777:Virus Diseases / Q000276:immunology / Q000473:pathology
chemical_list: D015415:Biomarkers; D018959:CD57 Antigens