A tale of two carboxypeptidases.
Proopiomelanocortin (Pomc) neurons play a central role in energy homeostasis. Despite the complexity of Pomc posttranslational processing, regulation of Pomc gene expression often takes center stage. Complementary papers that zero in on distinct carboxypeptidases (Plum et al., 2009; Wallingford et al., 2009) now refocus the spotlight on regulated peptide cleavage.
Low
Malcolm J
MJ
Departments of Molecular & Integrative Physiology and Internal Medicine, Brehm Center for Type 1 Diabetes Research & Analysis, University of Michigan, Ann Arbor, MI 48109-5622, USA. mjlow@umich.edu