title: Association of rs2781666 G/T polymorphism of arginase I gene with myocardial infarction in Tunisian male population.
abstract: OBJECTIVE
  The aim of this study was to investigate the association between rs2781666 G/T polymorphism of arginase I (ARG I) gene and myocardial infarction (MI) in the Tunisian male population.
  
  
  METHODS
  Three hundred eighteen patients with MI and 282 controls were recruited. The rs2781666 G/T polymorphism of ARG I was determined by PCR-RFLP analysis.
  
  
  RESULTS
  Patients had significantly higher frequency of TT genotype compared to controls (10.4% vs. 6.7%; p<0.001). The MI patients showed higher frequency of T allele compared to the controls [0.33 vs. 0.22; OR (95% CI), 1.79 (1.37-2.34), p<0.001]. The association between rs2781666 G/T polymorphism of ARG I gene and MI remained significant after adjustment for other well-established risk factors.
  
  
  CONCLUSIONS
  A significant association between rs2781666 G/T polymorphism of ARG I gene and MI was found in the Tunisian male population.
authors.affiliation: LR99ES11 Research Laboratory, Department of Biochemistry, Rabta Hospital, Tunis, Tunisia.
authors.forename: Yousra
authors.initials: Y
authors.lastname: Sediri
authors.forename: Amani
authors.initials: A
authors.lastname: Kallel
authors.forename: Samir
authors.initials: S
authors.lastname: Ben Ali
authors.forename: Souheil
authors.initials: S
authors.lastname: Omar
authors.forename: Mohamed Sami
authors.initials: MS
authors.lastname: Mourali
authors.forename: Monia
authors.initials: M
authors.lastname: Elasmi
authors.forename: Sameh Haj
authors.initials: SH
authors.lastname: Taieb
authors.forename: Haïfa
authors.initials: H
authors.lastname: Sanhaji
authors.forename: Moncef
authors.initials: M
authors.lastname: Feki
authors.forename: Rachid
authors.initials: R
authors.lastname: Mechmeche
authors.forename: Riadh
authors.initials: R
authors.lastname: Jemaa
authors.forename: Naziha
authors.initials: N
authors.lastname: Kaabachi
mesh_terms: D000328:Adult; D000368:Aged; D001119:Arginase / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014416:Tunisia / Q000453:epidemiology
chemical_list: D001119:Arginase