[Association between the serum HBV DNA loads normalized to hepatic parenchyma cell volume and the liver histopathologic inflammation gradings in the immune clearance phase].
OBJECTIVE
To investigate the relationship between the serum HBV DNA loads normalized to hepatic parenchyma cell volume and the liver histopathologic inflammation gradings in the immune clearance phase during the natural history of hepatitis B.


METHODS
Serum HBV DNA loads were detected by fluorescence polymerase chain reaction and normalized to hepatic parenchyma cell volume. The association between normalized HBV DNA loads and liver inflammation histopathologic grade were analyzed.


RESULTS
The serum HBV DNA loads in patients with liver inflammation histopathologic grading 1, 2, 3 and 4 were 8.20*10(5)+/-9.11*10, 1.36*10(6)+/-5.96*10, 8.12*10(5)+/-8.01*10 and 2.08*10(6)+/-3.69*10 copies/ml, respectively (P more than 0.05). But the serum HBV DNA loads normalized to hepatic parenchyma cell volume in their located fibrosis stage were 9.24*10(8)+/-935, 5.33*10(9)+/-756, 1.06*10(10)+/-1770 and 3.31*10(11)+/-518 copies/ml, respectively (P less than 0.05).


CONCLUSIONS
The serum HBV DNA load normalized to hepatic parenchyma cell volume in patients with different fibrosis stages is associated with liver histopathologic inflammation gradings.
Li
Xue-Jun
XJ
Department of Infectious Diseases, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Xie
Shi-Bin
SB
Zang
Xiao-Hong
XH
Zang
Ying
Y
Zhao
Zhi-Xin
ZX
Ke
Wei-Min
WM
Gao
Zhi-Liang
ZL
D000328:Adult; D044963:Biopsy, Fine-Needle; D004279:DNA, Viral / Q000097:blood*; D001330:Electronic Data Processing; D005260:Female; D006515:Hepatitis B virus / Q000276:immunology / Q000302:isolation & purification*; D019694:Hepatitis B, Chronic / Q000097:blood / Q000276:immunology / Q000473:pathology* / Q000821:virology*; D006801:Humans; D007249:Inflammation / Q000473:pathology / Q000821:virology; D008103:Liver Cirrhosis / Q000473:pathology* / Q000821:virology; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods; D012720:Severity of Illness Index; D019562:Viral Load; D055815:Young Adult
D004279:DNA, Viral