title: Factors influencing the interconversion of a new class of dibenzodiazepine sulfonamide atropisomers.
abstract: A novel family of atropisomers based on a conformationally constrained seven membered ring system is investigated using a combination of preparative chiral chromatography, circular dichroism, and other analytical techniques. The influence of structure on the rate of atropisomer interconversion was explored with a series of analogs showing a range of interconversion rates ranging from very fast (undetectable on the HPLC timescale) to very slow (half life of many days).
authors.affiliation: Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey, USA. christopher_welch@merck.com
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Welch
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Gong
authors.forename: Wes
authors.initials: W
authors.lastname: Schafer
authors.forename: Harry
authors.initials: H
authors.lastname: Chobanian
authors.forename: Linus
authors.initials: L
authors.lastname: Lin
authors.forename: Mirlinda
authors.initials: M
authors.lastname: Biba
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.forename: Adam
authors.initials: A
authors.lastname: Beard
mesh_terms: D014150:Antipsychotic Agents / Q000737:chemistry* / Q000145:classification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002942:Circular Dichroism / Q000379:methods; D006207:Half-Life; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry* / Q000145:classification*
chemical_list: D014150:Antipsychotic Agents; D013449:Sulfonamides