The Dachshund gene in development and hormone-responsive tumorigenesis.
The dachshund (dac) gene was initially described as a mutant phenotype in flies featuring extremely short legs relative to their body length. Functioning as a dominant suppressor of the ellipse mutation, a hypermorphic allele of the Epidermal Growth Factor Receptor (EGFR), the dac gene plays a key role in metazoan development, regulating ocular, limb, brain, and gonadal development. In the Drosophila eye, dac is a key component of the Retinal Determination Gene Network (RDGN) governing the normal initiation of the morphogenetic furrow and thereby eye development. Recent studies have demonstrated an important role for human Dachshund homologue (DACH1) in tumorigenesis, in particular, breast, prostate and ovarian cancer. The molecular mechanisms by which DACH1 regulates differentiation and tumorigenesis are discussed herein.
Popov
Vladimir M
VM
Department of Cancer Biology, Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Wu
Kongming
K
Zhou
Jie
J
Powell
Michael J
MJ
Mardon
Graeme
G
Wang
Chenguang
C
Pestell
Richard G
RG
D000818:Animals; D002454:Cell Differentiation; D004268:DNA-Binding Proteins; D004330:Drosophila / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D005136:Eye Proteins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D012160:Retina / Q000254:growth & development / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
C486747:DACH1 protein, human; C403064:DACH2 protein, human; D004268:DNA-Binding Proteins; C456264:Dach1 protein, mouse; C485735:Dach2 protein, mouse; D029721:Drosophila Proteins; D005136:Eye Proteins; D009687:Nuclear Proteins; D020033:Protein Isoforms; D014157:Transcription Factors; C103968:dac protein, Drosophila