Azide conjugatable and pH responsive near-infrared fluorescent imaging probes.
The synthesis and photophysical characteristics of a pH responsive near-infrared fluorescence imaging probe is described. A key feature is the ability to conjugate the probe by an alkyne-azide cycloaddition reaction and its reversible response of fluorescence intensity across the physiological pH range.
Murtagh
Julie
J
Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
Frimannsson
Daniel O
DO
O'Shea
Donal F
DF
D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry*; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D055668:Photochemical Processes; D013055:Spectrophotometry, Infrared
D000480:Alkynes; D001386:Azides; D005456:Fluorescent Dyes