title: Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker.
abstract: We have developed photoaffinity probes for gamma-secretase with a nitrobenzenesulfonamide-type linker that can be cleaved with 2-mercaptoethanol under physiological conditions.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yokoshima
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Abe
authors.forename: Naoto
authors.initials: N
authors.lastname: Watanabe
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kita
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kan
authors.forename: Takeshi
authors.initials: T
authors.lastname: Iwatsubo
authors.forename: Taisuke
authors.initials: T
authors.lastname: Tomita
authors.forename: Tohru
authors.initials: T
authors.lastname: Fukuyama
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology; D053829:Amyloid Precursor Protein Secretases / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006868:Hydrolysis; D009578:Nitrobenzenes / Q000138:chemical synthesis / Q000737:chemistry*; D019920:Photoaffinity Labels / Q000138:chemical synthesis / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D004151:Dipeptides; C419410:N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester; D009578:Nitrobenzenes; D019920:Photoaffinity Labels; D013449:Sulfonamides; D053829:Amyloid Precursor Protein Secretases