title: [A case of light chain deposition disease involving kidney and bone marrow with microangiopathic hemolytic anemia].
abstract: We report a case of light chain deposition disease in a 59-yr-old female showing deposition of monoclonal light chain in the kidney and bone marrow accompanied with a schistocytosis, the morphologic finding of microangiopathic hemolytic anemia. The immunofluorescence examination of the kidney revealed strongly stained kappa-light chain deposits on the glomerular mesangium and capillary wall, tubules, and vessel wall. The electron microscopy demonstrated electron-dense deposits on the glomerular basement membrane and mesangium. Anemia was observed with schistocytosis and Howell-Jolly body in the peripheral blood smears. The immunohistochemical examination of the bone marrow showed the presence of kappa-light chain deposits in scattered plasma cells and thickened vessel wall in the absence of a prominent plasma cell proliferation. Although an immunofixation electrophoresis failed to detect a monoclonal gammopathy, the presence of monoclonal protein could be identified by an abnormal kappa/lambda ratio on the serum free light chain analysis.
authors.affiliation: Department of Laboratory Medicine, Eulji University School of Medicine, Eulji General Hospital, Seoul, Kerea.
authors.forename: Young Uk
authors.initials: YU
authors.lastname: Cho
authors.forename: Hyun Sook
authors.initials: HS
authors.lastname: Chi
authors.forename: Chan Jeoung
authors.initials: CJ
authors.lastname: Park
authors.forename: Seongsoo
authors.initials: S
authors.lastname: Jang
authors.forename: Yong Mee
authors.initials: YM
authors.lastname: Cho
authors.forename: Jung Sik
authors.initials: JS
authors.lastname: Park
mesh_terms: D000743:Anemia, Hemolytic / Q000150:complications / Q000175:diagnosis*; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007678:Kidney Glomerulus / Q000473:pathology* / Q000648:ultrastructure; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications / Q000175:diagnosis* / Q000276:immunology
chemical_list: D007147:Immunoglobulin Light Chains