title: Epstein-Barr virus (EBV) associated lymphoepithelioma-like thymic carcinoma associated with paraneoplastic syndrome of polymyositis: a rare tumor with rare association.
abstract: Thymic carcinomas are rare neoplasms representing less than 1% of all thymic malignancies arising from thymic epithelium. Lymphoepithelioma-like thymic carcinoma is a high grade neoplasm with aggressive features and frequent metastasis. Association of lymphoepithelioma-like thymic carcinomas with Epstein-Barr virus was observed in several previously reported case reports. Paraneoplastic syndromes have been reported with lymphoepithelioma-like thymic carcinoma. We report a case of rare association of paraneoplastic syndrome of polymyositis with lymphoepithelioma-like thymic carcinoma. The case highlights generalized increase in fluoro-deoxy-glucose uptake in the skeletal muscles indicating biopsy proven polymyositis-a paraneoplastic syndrome.
authors.affiliation: Department of Nuclear Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.
authors.forename: Bhasker R
authors.initials: BR
authors.lastname: Koppula
authors.forename: Sudhakar
authors.initials: S
authors.lastname: Pipavath
authors.forename: David H
authors.initials: DH
authors.lastname: Lewis
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000000981:diagnostic imaging / Q000821:virology; D017285:Polymyositis / Q000150:complications* / Q000000981:diagnostic imaging / Q000821:virology; D013902:Radiography, Thoracic; D013953:Thymus Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000821:virology; D014057:Tomography, X-Ray Computed