title: Biosynthesis of resorcylic acid lactone (5S)-5-hydroxylasiodiplodin in Lasiodiplodia theobromae.
abstract: An administration study of (2)H-labeled precursors showed that the 9-hydroxydecanoyl unit, the acyl intermediate of lasiodiplodin (1), was also the intermediate of (5S)-5-hydroxylasiodiplodin (2) in Lasiodiplodia theobromae. The incorporation of [O-methyl-(2)H(3)]-lasiodiplodin (6) into 2 indicated that hydroxylation at C-5 occurred after cyclization.
authors.affiliation: Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Sapporo, Japan.
authors.forename: Takasumi
authors.initials: T
authors.lastname: Kashima
authors.forename: Kosaku
authors.initials: K
authors.lastname: Takahashi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Matsuura
authors.forename: Kensuke
authors.initials: K
authors.lastname: Nabeta
mesh_terms: D001203:Ascomycota / Q000201:enzymology / Q000378:metabolism*; D007553:Isotope Labeling; D007783:Lactones / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015025:Zearalenone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
chemical_list: C547203:5-hydroxylasiodiplodin; D007783:Lactones; D015025:Zearalenone