Improved synthesis of diethyl 2,6-dimethyl-4-aryl-4H-pyran-3,5-dicarboxylate under ultrasound irradiation.
Diethyl 2,6-dimethyl-4-aryl-4H-pyran-3,5-dicarboxylates (1) have been synthesized by the reaction of aryl aldehyde and 1,3-diketone catalyzed by ZnCl(2) under ultrasound irradiation. The effects of changes in the ultrasonic power, temperature, and reaction time are discussed. With the optimized reaction conditions, various aryl aldehydes were used to synthesize 4H-pyrans (1) under the influence of ultrasound irradiation. Compared with the conventional thermal methods, the remarkable advantages of this method are the simple experimental procedure, shorter reaction time and high yield of product.
Ni
Cheng-Liang
CL
College of Life Science and Bio-engineering, Beijing University of Technology, Beijing, PR China.
Song
Xiao-Hui
XH
Yan
Hong
H
Song
Xiu-Qing
XQ
Zhong
Ru-Gang
RG
D000447:Aldehydes / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002712:Chlorides / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013055:Spectrophotometry, Infrared / Q000379:methods; D013696:Temperature; D014465:Ultrasonics; D017967:Zinc Compounds / Q000737:chemistry
D000447:Aldehydes; D002264:Carboxylic Acids; D002712:Chlorides; D007659:Ketones; D011714:Pyrans; D017967:Zinc Compounds; C016837:zinc chloride