Progression of age-related macular degeneration after cataract surgery.
OBJECTIVE
To document age-related macular degeneration (AMD) progression after cataract surgery.


METHODS
Surgeons prospectively enrolled patients with nonneovascular AMD who were awaiting cataract surgery. Fluorescein angiography was performed preoperatively and at the postoperative week 1, month 3, and month 12 visits. Incidence of neovascular AMD development within 12 months after operation was the primary outcome measure.


RESULTS
A total of 108 subjects were enrolled. Of 86 eyes with preoperatively photographically confirmed nonneovascular AMD, 71 had gradable images by month 12. Neovascular AMD was observed in 9 of 71 eyes (12.7%; 95% confidence interval, 6.0%-22.7%). The progression rate between week 1 and month 12 decreased to 3 of 65 eyes (4.6%; 95% confidence interval, 1.0%-12.9%) after excluding 5 neovascular events identified on the postoperative week 1 visit and 1 case with missing photographs at this visit.


CONCLUSIONS
The low incidence rate of neovascular AMD development between 1 week and 1 year after cataract surgery did not support the hypothesis that cataract surgery increases the risk of AMD progression. Several eyes appeared to have disease progression on postsurgery week 1 fluorescein angiograms, suggesting that many cases of presumed progression to neovascular AMD following cataract surgery may have been present prior to cataract surgery, but not recognized owing to lens opacity.
Dong
Li Ming
LM
Department of Preventive Medicine, Stony Brook University School of Medicine, USA.
Stark
Walter J
WJ
Jefferys
Joan L
JL
Al-Hazzaa
Selwa
S
Bressler
Susan B
SB
Solomon
Sharon D
SD
Bressler
Neil M
NM
D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000150:complications*; D004396:Coloring Agents; D018450:Disease Progression; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007208:Indocyanine Green; D019654:Lens Implantation, Intraocular; D008268:Macular Degeneration / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011183:Postoperative Complications; D011446:Prospective Studies; D012307:Risk Factors
D004396:Coloring Agents; D007208:Indocyanine Green