title: Impact of preoperative anemia on cardiac surgery in octogenarians.
abstract: OBJECTIVE
  Preoperative anemia has been related with adverse outcomes in elective valve replacement and CABG surgery. Impact of preoperative anemia on outcome in octogenarians submitted to cardiopulmonary bypass (CPB) has not yet been precisely described.
  
  
  METHODS
  We analyzed association between preoperative hemoglobin level, minimum intraoperative and immediate postoperative hematocrit (HCT), and other co-morbidities and occurrence of adverse outcomes in 227 octogenarians who underwent cardiac surgery.
  
  
  RESULTS
  Frequency of preoperative anemia was 41.9% (40.4% in male and 43.5% in female patients). Postoperative mortality was 13.2% (9% in non-anemic patients vs. 18.9% in anemic). 44.5% of patients suffered at least one postoperative adverse outcome (43.1% non-anemic vs. 46.3% anemic). In multivariate analysis (after adjusting independent preoperative risk factors for operative mortality and EuroSCORE) preoperative creatinine level [odds ratio (OR), 2.29; 95% confidence interval (CI), 1.06-4.98; P=0.035], immediate postoperative HCT <24% (OR, 2.78; 95% CI, 1.04-7.38; P=0.039), perioperative red blood cell (RBC) transfusion (OR, 1.58; 95% CI, 1.24-2.00; P=0.0001), peripheral vascular disease (OR, 4.92; 95% CI, 1.45-16.69; P=0.012) and urgent surgery (OR, 10.57; 95% CI, 2.54-43.91; P=0.0001) were identified as independent predictors for in-hospital mortality.
  
  
  CONCLUSIONS
  Mortality and adverse postoperative outcome increase in anemic octogenarians undergoing cardiac surgery. Although mortality is directly related to immediate postoperative anemia, adverse outcomes mainly depend on associated co-morbidities.
authors.affiliation: Department of Cardiac Surgery, Instituto de Ciencias del Corazón (ICICOR), University Hospital, Avda. Ramón y Cajal, 3, 47005 Valladolid, Spain. ycarrascal@hotmail.com
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Carrascal
authors.forename: Laura
authors.initials: L
authors.lastname: Maroto
authors.forename: Juvenal
authors.initials: J
authors.lastname: Rey
authors.forename: Adolfo
authors.initials: A
authors.lastname: Arévalo
authors.forename: Jaime
authors.initials: J
authors.lastname: Arroyo
authors.forename: José R
authors.initials: JR
authors.lastname: Echevarría
authors.forename: Nuria
authors.initials: N
authors.lastname: Arce
authors.forename: Enrique
authors.initials: E
authors.lastname: Fulquet
mesh_terms: D000367:Age Factors; D000369:Aged, 80 and over; D000740:Anemia / Q000097:blood / Q000150:complications* / Q000401:mortality; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects* / Q000401:mortality; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000401:mortality; D003404:Creatinine / Q000097:blood; D017558:Elective Surgical Procedures; D017707:Erythrocyte Transfusion; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D017052:Hospital Mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D007902:Length of Stay; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D016491:Peripheral Vascular Diseases / Q000150:complications; D016016:Proportional Hazards Models; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D006454:Hemoglobins; D003404:Creatinine