title: Primary CD30/ALK-1 positive anaplastic large cell lymphoma of the skeletal muscle in a child.
abstract: Anaplastic large cell lymphoma (ALCL) represents approximately 10 to 30% of all childhood non-Hodgkin lymphomas. It frequently involves both lymph nodes and extranodal sites whereas primary or secondary muscular involvements are quite uncommon. We describe a case of an 8-year-old boy presented with one month progressively swelling right buttock mass without association of lymphadenopathy or skin extension. Biopsy of the lesion showed large anaplastic cells with voluminous and abundant cytoplasm as well as folded nuclei. The tumour cells were positive for CD30, CD3, EMA and ALK-1. Chemotherapy resulted in durable remission status. This case emphasizes the occurrence of anaplastic large cell lymphoma in the soft tissue and the favourable outcome of ALK-positive anaplastic large cell lymphoma.
authors.affiliation: Department of Pathology, Salah Azaïz Institute, Bab Saadoun, Tunis, Tunisia. maha.driss@rns.tn
authors.forename: M
authors.initials: M
authors.lastname: Driss
authors.forename: I
authors.initials: I
authors.lastname: Abbes
authors.forename: K
authors.initials: K
authors.lastname: Mrad
authors.forename: S
authors.initials: S
authors.lastname: Sassi
authors.forename: F
authors.initials: F
authors.lastname: Oubich
authors.forename: S
authors.initials: S
authors.lastname: Barsaoui
authors.forename: K B
authors.initials: KB
authors.lastname: Romdhane
mesh_terms: D030301:Activin Receptors, Type II / Q000096:biosynthesis*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D017730:Ki-1 Antigen / Q000096:biosynthesis*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D008297:Male; D019042:Muscle Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D018482:Muscle, Skeletal / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D017730:Ki-1 Antigen; C425364:ACVRL1 protein, human; D030301:Activin Receptors, Type II