The human bocaviruses: a review and discussion of their role in infection.
Respiratory tract infections are a leading cause of morbidity and mortality worldwide. The human bocavirus (HBoV) is a newly recognized human parvovirus first reported in 2005. Since its discovery, this virus has been associated with upper and lower respiratory tract disease and gastroenteritis worldwide. This article is a comprehensive review of what is known about HBoV. It includes an evaluation of diagnostic modalities, symptoms occurring in affected patients, and a discussion as to whether HBoV is responsible for identified clinical manifestations. The article reviews the incidence and effect of coinfection and updates on related members (HBoV-2 and HBoV-3) recently reported. Understanding of respiratory viruses such as HBoV remains vitally important to the health of adult and pediatric patients.
Chow
Brian D W
BD
Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Esper
Frank P
FP
D000818:Animals; D004195:Disease Models, Animal; D056661:Human bocavirus / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D010322:Parvoviridae Infections / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology*; D010802:Phylogeny; D012621:Seasons; D014776:Virus Cultivation