title: [Cycloartane triterpenoid of Cimicifuga foetida].
abstract: OBJECTIVE
  To study cycloartane triterpenoid of Cimicifuga foetida and their osteoclast inhibition activity.
  
  
  METHODS
  The compounds were isolated and purified by normal and reversed phase column chromatographic methods. Structures were identified by spectroscopic analyses. Their osteoclast inhibition activity was then studied.
  
  
  RESULTS
  Thirteen cycloartane triterpenoids were isolated from the rhizomes of C. foetida and were characterized as 25-O-acetyl-cimigenol (1), cimigenol (2), cimicidanol (3), 26-deoxyactein (4), asiaticoside A (5), 23-epi-26-deoxyactein (6), actein (7), 12beta-hydroxycimigenol (8), cimiside E (9), (23R, 24S) 25-O-acetyl-cimigenol-3-O-beta-D-xylopyranoside (10), (23R, 24S) cimigenol-3-O-beta-D-xylopyranoside (11), cimicifugoside H-1 (12) and cimicifugoside H-2 (13).
  
  
  CONCLUSIONS
  Compound 5 was isolated from this genus for the first time, compound 7 was isolated firstly from the plant and compound 2, 7, 10 and 11 exhibit osteoclast inhibition activity.
authors.affiliation: College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China. danc999@163.com
authors.forename: Chun
authors.initials: C
authors.lastname: Dan
authors.forename: Jian
authors.initials: J
authors.lastname: Liang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Lisheng
authors.initials: L
authors.lastname: Ding
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D031885:Cimicifuga / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D010010:Osteoclasts / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C085352:cycloartane