[Biological features of immunoglobulins of class G in mice fed with cattle brains for a long time].
It was found that mice fed with brain of cattle or brain of cattle with a meat-bone flour (1:1), were capable of producing immunoglobulins which interacted with DNA, and protein and lipid fractions of mouse brain. These immunoproteins also induced death of cells of L1210 line of murine leukemia via apoptosis accompanied by changes in the animal level of proteins Bcl-2, p53 and procaspase 3. The potentials of using this experimental animal model for studying cytopathogenetic mechanisms of transmissible spongiform encephalopathies are discussed.
Kozak
M R
MR
Vlizlo
V V
VV
Kit
Iu Ia
IuIa
Stoĭka
R S
RS
D000821:Animal Feed; D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000276:immunology; D015153:Blotting, Western; D001921:Brain / Q000201:enzymology / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D053148:Caspase 3 / Q000378:metabolism; D002417:Cattle; D045744:Cell Line, Tumor; D004247:DNA / Q000276:immunology; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology* / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D017096:Prion Diseases / Q000276:immunology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D007074:Immunoglobulin G; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D004247:DNA; C427203:calf thymus DNA; D053148:Caspase 3