title: Clinical aspects of invasive candidiasis in critically ill patients.
abstract: Invasive candidiasis has emerged as an important cause of morbidity and mortality in intensive care unit patients. This short review focuses on many aspects of Candida infection in critically ill patients including epidemiology, impact on mortality, problems related to diagnosis, strategies to identify patients at risk of developing fungal infections, role of prophylaxis and pre-emptive strategies, empiric treatment and the role of different classes of antifungal drugs. New antifungal agents, specifically new azoles and echinocandins are discussed.
authors.affiliation: Institute of Intensive Care and Anaesthesiology, University A. Gemelli General Hospital, Rome, Italy.
authors.forename: Mariano
authors.initials: M
authors.lastname: Pennisi
authors.forename: Massimo
authors.initials: M
authors.lastname: Antonelli
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D016638:Critical Illness; D004359:Drug Therapy, Combination; D006801:Humans; D018570:Risk Assessment
chemical_list: D000935:Antifungal Agents