Fibrinogen and histidine-rich glycoprotein in early-onset preeclampsia.
OBJECTIVE
To determine whether plasma levels of fibrinogen and the placental tissue distributions of fibrinogen and histidine-rich glycoprotein (HRG) differ between early- and late-onset preeclampsia.


METHODS
The study comprised 18 women with early-onset (gestational weeks 24-32) and 19 women with late-onset (gestational weeks 35-42) preeclampsia. As controls concerning the plasma levels of fibrinogen, we used samples from non-pregnant fertile women, healthy pregnant women at gestational weeks 24-32 and healthy pregnant women at gestational weeks 35-42. Placental samples from women with healthy pregnancies at gestational weeks 35-42 served as controls in the immunohistochemical staining.


METHODS
Uppsala University Hospital, Uppsala.


METHODS
Plasma fibrinogen levels were analyzed and the placental tissue expression of fibrinogen and HRG determined by immunohistochemistry.


RESULTS
Plasma level of fibrinogen was increased in early-onset, but not late-onset, preeclampsia. Levels of fibrinogen were significantly lower, and that of HRG significantly higher, in placentas from women with early-onset preeclampsia as compared with control placentas (p = 0.01 and 0.001).


CONCLUSIONS
HRG and fibrinogen might be involved in the hypercoagulability and the angiogenic imbalance seen in early-onset preeclampsia.
Kårehed
Karin
K
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Wikström
Anna-Karin
AK
Olsson
Anna-Karin
AK
Larsson
Anders
A
Olovsson
Matts
M
Akerud
Helena
H
D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D001777:Blood Coagulation / Q000502:physiology; D042783:Endothelial Cells / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011506:Proteins / Q000032:analysis*; D014018:Tissue Distribution; D000099053:Histidine-Rich Glycoprotein
D014408:Biomarkers, Tumor; D011506:Proteins; D000099053:Histidine-Rich Glycoprotein; D005340:Fibrinogen