title: Autonomic impairment after myocardial infarction: role in cardiac remodelling and mortality.
abstract: 1. Impairmant of baroreflex sensitivity (BRS) has been implicated in the reduction of heart rate variability (HRV) and in the increased risk of death after myocardial infarction (MI). In the present study, we investigated whether the additional impairment in BRS induced by sinoaortic baroreceptor denervation (SAD) in MI rats is associated with changes in the low-frequency (LF) component of HRV and increased mortality rate. 2. Rats were randomly divided into four groups: control, MI, denervated (SAD) and SAD + MI rats. Left ventricular (LV) function was evaluated by echocardiography. Autonomic components were assessed by power spectral analysis and BRS. 3. Myocardial infarction (90 days) reduced ejection fraction (by approximately 42%) in both the MI and SAD + MI groups; however, an increase in LV mass and diastolic dysfunction were observed only in the SAD + MI group. Furthermore, BRS, HRV and the LF power of HRV were reduced after MI, with an exacerbated reduction seen in SAD + MI rats. The LF component of blood pressure variability (BPV) was increased in the MI, SAD and SAD + MI groups compared with the control group. Mortality was higher in the MI groups compared with the non-infarcted groups, with an additional increase in mortality in the SAD + MI group compared with the MI group. Correlations were obtained between BRS and the LF component of HRV and between LV mass and the LF component of BPV. 4. Together, the results indicate that the abolishment of BRS induced by SAD in MI rats further reduces the LF band of HRV, resulting in a worse cardiac remodelling and increased mortality in these rats. These data highlight the importance of this mechanism in the prognosis of patients after an ischaemic event.
authors.affiliation: Hypertension Unit, Heart Institute (InCor), Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Mostarda
authors.forename: Bruno
authors.initials: B
authors.lastname: Rodrigues
authors.forename: Matheus
authors.initials: M
authors.lastname: Vane
authors.forename: Edson D
authors.initials: ED
authors.lastname: Moreira
authors.forename: Kaleizu T
authors.initials: KT
authors.lastname: Rosa
authors.forename: Ivana C
authors.initials: IC
authors.lastname: Moraes-Silva
authors.forename: Silvia
authors.initials: S
authors.lastname: Lacchini
authors.forename: Dulce E
authors.initials: DE
authors.lastname: Casarini
authors.forename: Kátia
authors.initials: K
authors.lastname: De Angelis
authors.forename: Maria Claudia
authors.initials: MC
authors.lastname: Irigoyen
mesh_terms: D000818:Animals; D001011:Aorta / Q000294:innervation; D017763:Autonomic Denervation / Q000009:adverse effects / Q000401:mortality; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000175:diagnosis / Q000401:mortality* / Q000503:physiopathology*; D017704:Baroreflex / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002346:Carotid Sinus / Q000294:innervation; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis / Q000401:mortality* / Q000503:physiopathology*; D009929:Organ Size; D011311:Pressoreceptors / Q000601:surgery; D011379:Prognosis; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors; D013318:Stroke Volume / Q000502:physiology; D014630:Vagus Nerve / Q000601:surgery; D020257:Ventricular Remodeling / Q000502:physiology*