The association between interleukin-23 receptor gene polymorphisms and systemic lupus erythematosus.
The aim of this study was to investigate single-nucleotide polymorphism of the IL-23R gene and its possible relationship with systemic lupus erythematosus (SLE) in a Chinese population. We examined 139 SLE patients and 168 controls from Sichuan province in China. The genotyping of IL-23R is determined by polymerase chain reaction-restriction fragment length polymorphism. These results indicate that there is no relationship between IL-23R polymorphisms and SLE in a Chinese population. Further studies are still needed to explore the complicated interaction between environmental factors and IL-23R polymorphisms in the risk of SLE, particularly in ethnically different populations. There were no significant differences in the genotype and allele frequencies of rs10889677, rs1884444, and rs7517847 polymorphisms between the patients with SLE and the control group in a Chinese population (for rs10889677: odds ratio [OR] = 1.00, 95% confidence interval [CI] = 0.69-1.45; for rs1884444: OR = 0.96, 95% CI = 0.69-1.33; and for rs7517847: OR = 0.93, 95% CI = 0.67-1.27).
Li
Yi
Y
1 Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University , Chengdu, People's Republic of China .
Liang
Wei-Bo
WB
Li
Cui
C
Gao
Lin-Bo
LB
Zhou
Bin
B
Wang
Yan-Yun
YY
Lv
Mei-Li
ML
Song
Ya-Ping
YP
Zhang
Lin
L
D000328:Adult; D001483:Base Sequence; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D053759:Interleukin-23 / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D012015:Reference Standards
D053759:Interleukin-23