Effects of diterpenes from latex of Euphorbia lactea and Euphorbia laurifolia on human immunodeficiency virus type 1 reactivation.
The persistence of latent HIV-infected cellular reservoirs represents the major hurdle to virus eradication in patients treated with highly active antiretroviral therapy, referred to as HAART. HIV-1 reservoirs are long-lived resting CD4+ memory cells containing the virus latently integrated. Since the HIV-1 reservoirs are not targeted by HAART, reactivation therapy has been suggested to purge viral latency. Bioassay-guided study of an ethyl acetate extract of Euphorbia laurifolia afforded two isomeric diterpenes that showed differential activity over HIV-1 reactivation. A previously reported compound was isolated too from Euphorbia lactea. This compound showed a potent HIV-1 reactivating effect. Bioassays results showed that HIV-1 reactivation activity is influenced by distinct structural characteristics.
Avila
Liliana
L
Grupo de Química Orgánica de Productos Naturales, Instituto de Quimica, Universidad de Antioquia, Medellín, Colombia.
Perez
Moises
M
Sanchez-Duffhues
Gonzalo
G
Hernández-Galán
Rosario
R
Muñoz
Eduardo
E
Cabezas
Fabio
F
Quiñones
Winston
W
Torres
Fernando
F
Echeverri
Fernando
F
D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D028481:Euphorbia / Q000737:chemistry*; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D019169:Jurkat Cells; D007840:Latex / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014775:Virus Activation / Q000187:drug effects*; D017735:Virus Latency / Q000187:drug effects
D000998:Antiviral Agents; D004224:Diterpenes; D007840:Latex; D010936:Plant Extracts