title: The uptake of a labeled double-stranded polynucleotide by cultured rabbit kidney cells: an electron microscopic study.
abstract: Polyribocytidylate-(3)H-polyriboinosinate (rC-(3)H:rI) enters cultured rabbit kidney cells from the surrounding medium within (1/2) hr after exposure. Grains are found in the cytoplasm, nucleus, and nucleolus. At 2 hr, grains are localized predominantly over the nucleolar regions. Subsequently, the grains in the nucleus become dispersed. A specific receptor site for the initiation of interferon production was not revealed.
authors.affiliation: Departments of Pathology, Dermatology, and Virology, New York University School of Medicine, New York 10016.
authors.forename: P H
authors.initials: PH
authors.lastname: Prose
authors.forename: A
authors.initials: A
authors.lastname: Friedman-Kien
authors.forename: J
authors.initials: J
authors.lastname: Vilcek