title: Harzianic acid, an antifungal and plant growth promoting metabolite from Trichoderma harzianum.
abstract: A Trichoderma harzianum strain, isolated from composted hardwood bark in Western Australia, was found to produce a metabolite with antifungal and plant growth promoting activity. The structure and absolute configuration of the fungal compound, harzianic acid (1), were determined by X-ray diffraction studies. Harzianic acid showed antibiotic activity against Pythium irregulare, Sclerotinia sclerotiorum, and Rhizoctonia solani. A plant growth promotion effect was observed at low concentrations of 1.
authors.affiliation: School of Earth and Geographical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, 6009. frvinale@unina.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Vinale
authors.forename: Gavin
authors.initials: G
authors.lastname: Flematti
authors.forename: Krishnapillai
authors.initials: K
authors.lastname: Sivasithamparam
authors.forename: Matteo
authors.initials: M
authors.lastname: Lorito
authors.forename: Roberta
authors.initials: R
authors.lastname: Marra
authors.forename: Brian W
authors.initials: BW
authors.lastname: Skelton
authors.forename: Emilio L
authors.initials: EL
authors.lastname: Ghisalberti
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects; D018360:Crystallography, X-Ray; D006885:Hydroxybutyrates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010937:Plant Growth Regulators / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011775:Pythium / Q000187:drug effects; D012232:Rhizoctonia / Q000187:drug effects*; D014242:Trichoderma / Q000737:chemistry*; D014904:Western Australia
chemical_list: D000935:Antifungal Agents; D006885:Hydroxybutyrates; D010937:Plant Growth Regulators; D011758:Pyrroles; C088506:harzianic acid