title: A comparative study to assess the effect of amikacin sulfate bladder wash on catheter-associated urinary tract infection in neurosurgical patients.
abstract: BACKGROUND
  The indwelling urinary catheter is an essential part of modern medical care. Unfortunately, when poorly managed, the indwelling catheter may present a hazard to the very patients it is designed to protect. Catheter-associated urinary tract infection (CAUTI) is the most common nosocomial infection in hospitals and nursing homes.
  
  
  OBJECTIVE
  The primary objective was to study the effect of amikacin sulfate bladder wash on CAUTI in neurosurgical patients. The other objectives were to study the various organisms causing CAUTI and their antibiotic sensitivity and resistance pattern.
  
  
  METHODS
  This was a prospective randomized controlled study performed on 60 patients who met the inclusion criteria at the neurosurgical intensive care of the All India Institute of Medical Sciences between June and December 2006. The patients were randomized into two groups - one was the trial group which received amikacin bladder wash, while the other was the control group that did not receive any bladder wash.
  
  
  RESULTS
  Forty percent of the subjects in the control group developed CAUTI, while none of the subjects in study group developed CAUTI. (Fisher's exact test, P value < 0.001) Pseudomonas aeruginosa (51%) was the commonest pathogen.
  
  
  CONCLUSIONS
  Amikacin sulfate bladder wash was effective in preventing CAUTI. It can thus decrease the antibiotic usage thereby preventing the emergence of antibiotic resistance.
authors.affiliation: College of Nursing, New Delhi, India.
authors.forename: Sumi
authors.initials: S
authors.lastname: Zacharias
authors.forename: Srinivas
authors.initials: S
authors.lastname: Dwarakanath
authors.forename: Meena
authors.initials: M
authors.lastname: Agarwal
authors.forename: Bhavani Shankar
authors.initials: BS
authors.lastname: Sharma