title: Gray matter alterations in obsessive-compulsive disorder: an anatomic likelihood estimation meta-analysis.
abstract: Many voxel-based morphometry (VBM) studies have found abnormalities in gray matter density (GMD) in obsessive-compulsive disorder (OCD). Here, we performed a quantitative meta-analysis of VBM studies contrasting OCD patients with healthy controls (HC). A literature search identified 10 articles that included 343 OCD patients and 318 HC. Anatomic likelihood estimation meta-analyses were performed to assess GMD changes in OCD patients relative to HC. GMD was smaller in parieto-frontal cortical regions, including the supramarginal gyrus, the dorsolateral prefrontal cortex, and the orbitofrontal cortex, and greater in the basal ganglia (putamen) and the anterior prefrontal cortex in OCD patients relative to HC. No significant differences were found between children and adults. Our findings indicate differences in GMD in parieto-frontal areas and the basal ganglia between OCD patients and HC. We conclude that structural abnormalities within the prefrontal-basal ganglia network are involved in OCD pathophysiology.
authors.affiliation: Laboratoire Mouvement Adaptation Cognition, CNRS UMR 5227, Université Bordeaux 2, Bordeaux, France. jeanyves.rotge@mac.com
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Rotge
authors.forename: Nicolas
authors.initials: N
authors.lastname: Langbour
authors.forename: Dominique
authors.initials: D
authors.lastname: Guehl
authors.forename: Bernard
authors.initials: B
authors.lastname: Bioulac
authors.forename: Nematollah
authors.initials: N
authors.lastname: Jaafari
authors.forename: Michele
authors.initials: M
authors.lastname: Allard
authors.forename: Bruno
authors.initials: B
authors.lastname: Aouizerate
authors.forename: Pierre
authors.initials: P
authors.lastname: Burbaud
mesh_terms: D000293:Adolescent; D000328:Adult; D001479:Basal Ganglia / Q000473:pathology; D001931:Brain Mapping / Q000379:methods* / Q000706:statistics & numerical data; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000473:pathology*; D002648:Child; D006801:Humans; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000473:pathology*; D010296:Parietal Lobe / Q000473:pathology; D055815:Young Adult