title: Natural course of the remnant hepatic functional reserve as estimated by technetium-99m-galactosyl human serum albumin scintigraphy after a hepatectomy.
abstract: BACKGROUND
  Technetium-99m-galactosyl human serum albumin (GSA) scintigraphy provides an accurate estimation of the hepatic functional reserve but is not applied after a hepatectomy. The aim of this study was to elucidate the natural course of the remnant hepatic functional reserve (RHFR) after hepatectomy by GSA scintigraphy.
  
  
  METHODS
  Eighty-six patients (partial hepatic resection, Hr0 = 46; sectionectomy, Hr1 = 21; bisectionectomy, Hr2 = 19) classified as Child-Pugh class A before the hepatectomy were enrolled, and GSA scintigraphy to detect HH15 (uptake ratio of the heart at 15 min to that at 3 min) and LHL15 (uptake ratio of the liver at 15 min to the liver plus the heart at 15 min) was performed periodically before and after the hepatectomy. HH15, LHL15, and the percentages of patients that recovered to the preoperative levels of these entities were estimated. In addition, hematobiochemical tests and the remnant liver volume were also periodically monitored.
  
  
  RESULTS
  HH15 and LHL15 levels deteriorated until 2 months postoperatively (PO) after the procedure and subsequently recovered to the preoperative levels at 6 months PO in Hr0 patients. In Hr1 patients, but not in Hr2 patients, these levels also deteriorated until 3 months PO and had improved by 6 months after the surgery. Only 40% of the patients showed recovery to the preoperative levels by 6 months PO in the Hr0 group; furthermore, the percentage of patients who showed recovery to the preoperative levels by 6 months PO was under 40% in the Hr1 group and around 10% in the Hr2 group. However, the results of hematobiochemical tests and the remnant liver volume in all types of hepatectomies were rapidly normalized after the hepatectomy.
  
  
  CONCLUSIONS
  Remnant hepatic functional reserve estimated by GSA scintigraphy revealed that a larger resected liver volume induced both more serious and continued remnant hepatic dysfunction in comparison to results shown by hematobiochemical tests, while the functional regeneration was also appreciably slower and more gradual in comparison to the volume regeneration.
authors.affiliation: Division of Gastroenterological and General Surgery, Department of Surgery, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. yoppy1203@med.showa-u.ac.jp
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Aoki
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Kusano
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Matsuda
authors.forename: Yuta
authors.initials: Y
authors.lastname: Enami
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yasuda
authors.forename: Tomotake
authors.initials: T
authors.lastname: Koizumi
authors.forename: Takashi
authors.initials: T
authors.lastname: Niiya
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Murai
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Kato
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Kusano
authors.forename: Masahiko
authors.initials: M
authors.lastname: Murakami
mesh_terms: D000368:Aged; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000601:surgery; D008115:Liver Regeneration; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging / Q000379:methods*; D019275:Radiopharmaceuticals; D012720:Severity of Illness Index; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; D016284:Technetium Tc 99m Pentetate