title: [Toxicity and toxin profiles of xanthid crabs collected around Nakanoshima in the Tokara Islands, Japan].
abstract: A total of 36 specimens of 5 xanthid crab species, Zosimus aeneus (n=16), Xanthias lividus (n=4), Leptodius sanguineus (n=3), Daira perlata (n=10) and Eriphia sebana (n=3), were collected around Nakanoshima Island, which is located at the northeastern part of the Tokara Islands, Kagoshima Prefecture, Japan in May and July 2000, and their toxicity was determined by mouse bioassay. Nine of 16 Z. aeneus specimens and all of 4 X. lividus specimens showed lethal potency to mice (2.1-11 MU/g, 2.8-8.6 MU/g, respectively), whereas all the other species were non-toxic (less than 2.0 MU/g). LC/MS analyses indicated that the toxin of the Z. aeneus specimens was mainly composed of tetrodotoxin (41% of total toxicity), and 11-oxotetrodotoxin contributed to the remaining toxicity. The toxin of the X. lividus specimens, however, was apparently not tetrodotoxin. In HPLC-FLD analyses, no paralytic shellfish poison component was detected in either of the two toxic species.
authors.affiliation: Department of Science for Living, Shikoku University, Junior College, Furukawa, Tokushima, Japan.
authors.forename: Takefumi
authors.initials: T
authors.lastname: Sagara
authors.forename: Shigeto
authors.initials: S
authors.lastname: Taniyama
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Takatani
authors.forename: Naoyoshi
authors.initials: N
authors.lastname: Nishibori
authors.forename: Sachio
authors.initials: S
authors.lastname: Nishio
authors.forename: Tamao
authors.initials: T
authors.lastname: Noguchi
authors.forename: Osamu
authors.initials: O
authors.lastname: Arakawa
mesh_terms: D000818:Animals; D003386:Brachyura / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D005260:Female; D005517:Foodborne Diseases / Q000209:etiology; D007564:Japan; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D013045:Species Specificity; D013779:Tetrodotoxin / Q000031:analogs & derivatives* / Q000032:analysis / Q000302:isolation & purification* / Q000633:toxicity*
chemical_list: C104261:11-oxotetrodotoxin; D013779:Tetrodotoxin