STUDIES IN THE RELATION OF THE HEMOLYTIC STREPTOCOCCUS TO RHEUMATIC FEVER : III. COMPLEMENT FIXATION VERSUS STREPTOCOCCAL NUCLEOPROTEINS WITH THE SERA OF PATIENTS WITH RHEUMATIC FEVER AND OTHERS.
Complement-fixing antibodies to the cytoplasmic particles (CP) and to the S fraction of streptococcal nucleoproteins are present in normal human sera, the range of concentrations varying among the age groups. The titer of these antibodies rises between the first half-week and the 3rd week of scarlet fever, in more than 80 per cent of the cases. The titers then remain elevated for at least 4 months. In children, 91 per cent of the normal sera examined showed anti-CP titers up to 32; 87 per cent of sera in active rheumatic disease had titers above this level. Corresponding data with S fell in the same range of percentage distribution. Anti-CP and anti-S titers remained elevated long after the rheumatic process had reached quiescence. No correlation of serologic titer with the degree of clinical activity was found in the case of either antibody.
Harris
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The Children's Hospital of Philadelphia (Department of Pediatrics, School of Medicine, University of Pennsylvania), the Children's Seashore House for Invalid Children, Atlantic City, and the Philadelphia General Hospital.
D000906:Antibodies; D002648:Child; D006801:Humans; D009698:Nucleoproteins; D012213:Rheumatic Fever; D013291:Streptococcus
D000906:Antibodies; D009698:Nucleoproteins