title: [Evaluation of factor for one-point venous blood sampling method based on the causality model].
abstract: OBJECTIVE
  One-point venous blood sampling method (Mimura, et al.) can evaluate the rCBF value with a high degree of accuracy. However, the method is accompanied by complexity of technique because it requires a venous blood Octanol value, and its accuracy is affected by factors of input function. Therefore, we evaluated the factors that are used for input function to determine the accuracy input function and simplify the technique.
  
  
  METHODS
  The input function which uses the time-dependent brain count of 5 minutes, 15 minutes, and 25 minutes from administration, and the input function in which an objective variable is used as the artery octanol value to exclude the venous blood octanol value are created. Therefore, a correlation between these functions and rCBF value by the MS method is evaluated.
  
  
  RESULTS
  Creation of a high-accuracy input function and simplification of technique are possible. The rCBF value obtained by the input function, the factor of which is a time-dependent brain count of 5 minutes from administration, and the objective variable is artery octanol value, had a high correlation with the MS method (y=0.899x+4.653, r=0.842).
authors.affiliation: Program in Health and Welfare, Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima.
authors.forename: Norikazu
authors.initials: N
authors.lastname: Matsutomo
authors.forename: Kouichi
authors.initials: K
authors.lastname: Kobara
authors.forename: Fumie
authors.initials: F
authors.lastname: Sasaki
authors.forename: Haruo
authors.initials: H
authors.lastname: Watanabe
authors.forename: Akio
authors.initials: A
authors.lastname: Nagaki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Mimura
authors.forename: Hideo
authors.initials: H
authors.lastname: Onishi
mesh_terms: D000368:Aged; D001800:Blood Specimen Collection / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008962:Models, Theoretical; D000442:Octanols; D015899:Tomography, Emission-Computed, Single-Photon; D014680:Veins
chemical_list: D000442:Octanols