[Preparation and in vitro release of Maiyanning sustained-release patches].
OBJECTIVE
To prepare Maiyanning sustained-release patches and optimize the prescription.


METHODS
The mono-factor design was used to screen the formulation of the sustained-release patches.


RESULTS
The optimal composition of the formulation was MD-607 as the pressure sensitive adhesive and azone as the penetration enhancer with the content of 5.0%. Drugs released from the pressure-sensitive adhesive patches in a constant speed, it confirmed that the drug was released by zero order equation from the patches.


CONCLUSIONS
The prepared patches have an ideal release trait.
Yuan
Sumin
S
Pharmaceutical Department, Beijing Uinversity of Chinese Medicine, Beijing 100102, China.
Ni
Jian
J
D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D007700:Kinetics; D012995:Solubility
D004304:Dosage Forms; D004365:Drugs, Chinese Herbal