Mitotic inheritance of the Golgi complex.
In mammals, the Golgi complex is structured in the form of a continuous membranous system composed of stacks connected by tubular bridges, the "Golgi ribbon". At the onset of mitosis, the Golgi complex undergoes a multi-step fragmentation process that is required for its correct partition into the dividing cells. Regulation of Golgi fragmentation and cell cycle progression appear to be precisely coordinated. Here, we review recent studies that are revealing the fundamental mechanisms, the molecular players and the biological significance of the mitotic inheritance of the Golgi complex in mammalian cells.
Persico
Angela
A
Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (Chieti), Italy.
Cervigni
Romina Ines
RI
Barretta
Maria Luisa
ML
Colanzi
Antonino
A
D000818:Animals; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D040582:Inheritance Patterns; D007425:Intracellular Membranes / Q000378:metabolism; D008938:Mitosis