[Vascular diseases in first-degree relatives of patients with intracranial aneurysms].
An aim of the study was to compare frequencies of vascular diseases in first-degree relatives (FDR) of patients with intracranial aneurysms (IA) and FDR of controls. Pedigrees have been selected through interviews in 194 patients with IA (96 men and 98 women) and in 193 age- and sex-matched controls. Only FDR with complete information about their disorders have been included in the study: 1011 FDR of patients with IA and 812 controls. The frequency of strokes was 2.5 times and hemorrhages --3.7 times higher in FDR of patients with IA compared to controls. Only 0.9% of FDR of patients with IA had the rupture of intracranial aneurysm. The frequency of headaches was 2.8 times, ischemic heart disease--2.7 times and arterial hypertension --2 times greater in FDR of patients with IA compared to controls. Moreover, sudden death occurred 5.8 times more often in FDR of patients with IA. The data obtained suggest that vascular defects leading to the development of IA may be, in part, genetically determined. Prevention of stroke and cardiovascular disease is necessary for FDR of patients with IA.
Lebedeva
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ER
Sakovich
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VP
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D002532:Intracranial Aneurysm / Q000150:complications* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014652:Vascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D055815:Young Adult