Ultrasonic sonoporation can enhance the prostate permeability.
As possible existence of the blood-prostate barrier and decreased prostate permeability due to inflammation, it is difficult to form an effective drug concentration in prostate tissues, which influences medication efficacy. This is one of principal reasons why it is difficult to treat prostate diseases including prostatitis etc. How to increase the permeability of drugs into prostate is inevitable to become an issue concerned by clinical research. Ultrasonic sonoporation may increase permeability of cells and tissues, so we propose a hypothesis that sonoporation induced by ultrasonic cavitation may increase the permeability of prostate tissues. This may be a non-invasive physical treatment method, and it has better safety and validity, and higher clinical value.
Liu
Yongliang
Y
Department of Urology, Xinqiao Hospital of Third Military Medical University, Chongqing 400037, China. liangfromlyl@163.com
Liu
Zheng
Z
Li
Tao
T
Ye
Gang
G
D018274:Electroporation / Q000379:methods*; D006801:Humans; D008297:Male; D008954:Models, Biological; D010539:Permeability; D011467:Prostate / Q000502:physiology* / Q000528:radiation effects*; D013010:Sonication / Q000379:methods*