Improvement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoids.
OBJECTIVE
To evaluate the hematological profile, oxidative stress, and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoids for 12 months.


METHODS
Twenty-one beta-thalassemia/Hb E patients were given 2 capsules of 250 mg each of curcuminoids (a total of 500 mg) daily for 12 months. Blood was collected every 2 months during treatment and 3 months after withdrawal and was determined for complete blood count, malonyldialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), reduced glutathione (GSH) in red blood cells (RBC), and non-transferrin bound iron (NTBI) in serum.


RESULTS
The increased oxidative stress in beta-thalassemia/Hb E patients was shown by higher levels of MDA, SOD, GSH-Px in RBC, serum NTBI, and lower level of RBC GSH. Curcuminoids administration resulted in improvement of all the measured parameters as long as they were administered. After 3 months withdrawal of treatment, all parameters returned close to baseline levels.


CONCLUSIONS
Curcuminoids may be used to ameliorate oxidative damage in patients with beta-thalassemia/Hb E disease.
Kalpravidh
Ruchaneekorn W
RW
Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok 10700, Thailand. sirkp@mahidol.ac.th
Siritanaratkul
Noppadol
N
Insain
Praphaipit
P
Charoensakdi
Ratiya
R
Panichkul
Narumol
N
Hatairaktham
Suneerat
S
Srichairatanakool
Somdet
S
Phisalaphong
Chada
C
Rachmilewitz
Eliezer
E
Fucharoen
Suthat
S
D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D003474:Curcumin / Q000494:pharmacology* / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006446:Hemoglobin E / Q000378:metabolism*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000097:blood; D055815:Young Adult; D017086:beta-Thalassemia / Q000097:blood / Q000188:drug therapy*
D000975:Antioxidants; D004791:Enzyme Inhibitors; D008315:Malondialdehyde; D006446:Hemoglobin E; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D003474:Curcumin