title: Polymorphism of tumor protein p53 codon 72 showed no association with oral lichen planus in Shiraz, Iran.
abstract: BACKGROUND
  Oral lichen planus (OLP) is a chronic relapsing inflammatory disease involving T-lymphocyte aggression targeted to the basal layer of the oral mucosa. The tumor suppressor tumor protein p53 (TP53), located on chromosome 17, has been involved in various malignancies.
  
  
  OBJECTIVE
  This study was undertaken to investigate the association of p53 codon 72 polymorphism with OLP in Southern Iranian patients.
  
  
  METHODS
  Twenty-five patients with lichen planus and 93 healthy blood donors as control group were recruited. DNA from peripheral blood mononuclear cells was extracted and amplified using allele-specific polymerase chain reaction.
  
  
  RESULTS
  The frequency of homozygotic arginine (Arg) at codon 72 was 44% in the patients and 37.6% in the controls; for homozygotic proline (Pro), it was 24% and 15.15%, respectively, and for heterozygotic arginine/proline, it was 32% and 47.3%, respectively.
  
  
  CONCLUSIONS
  The polymorphism in codon 72 of the TP53 gene was not associated with the OLP in Iranian patients.
authors.affiliation: Department of Oral Medicine, Dental School, Shiraz University of Medical Sciences, Shiraz, Fars, Iran.
authors.forename: Jannan
authors.initials: J
authors.lastname: Ghabanchi
authors.forename: Mohmmad Javad
authors.initials: MJ
authors.lastname: Fattahi
authors.forename: Maryam
authors.initials: M
authors.lastname: Mardani
authors.forename: Azadeh Andisheh
authors.initials: AA
authors.lastname: Tadbir
authors.forename: Abass Ali
authors.initials: AA
authors.lastname: Paydar
mesh_terms: D000328:Adult; D001120:Arginine / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007492:Iran; D017676:Lichen Planus, Oral / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011392:Proline / Q000235:genetics; D017422:Sequence Analysis, DNA; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53; D001120:Arginine; D011392:Proline