Supramolecular protein cage composite MR contrast agents with extremely efficient relaxivity properties.
A DTPA-Gd containing polymer was grown in the interior of a heat shock protein cage resulting in T(1) particle relaxivities of 4200 mM(-1) sec(-1) for the 12 nm particle. Relaxivity parameters were determined, and this analysis suggests that the rotational correlation time has been optimized while the water exchange lifetime is longer than optimal. This synthetic approach holds much promise for the development of next generation contrast agents and this report will aid in their design.
Liepold
Lars O
LO
Department of Chemistry and Biochemistry, Center for BioInspired Nanomaterials, Montana State University, Bozeman, Montana, USA.
Abedin
Md Joynal
MJ
Buckhouse
Emily D
ED
Frank
Joseph A
JA
Young
Mark J
MJ
Douglas
Trevor
T
D003287:Contrast Media / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D019786:Gadolinium DTPA / Q000737:chemistry*; D006360:Heat-Shock Proteins / Q000737:chemistry*; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D046912:Multiprotein Complexes / Q000737:chemistry; D019047:Phantoms, Imaging
D003287:Contrast Media; D004337:Drug Carriers; D006360:Heat-Shock Proteins; D046912:Multiprotein Complexes; D019786:Gadolinium DTPA