APPLICATION OF THE DIFFUSION HYPOTHESIS TO MEMBRANE POTENTIALS.
A system consisting of two aqueous solutions, containing equal concentrations of lactic acid, but different concentrations of Na lactate, separated by a layer of amyl alcohol has been described. This system exhibits electrical properties ranging (as the concentration of NaL is increased) from those characteristic of a simple Donnan equilibrium to those characteristic of simple diffusion. The fact that the Donnan P.D. can be treated as a special case of a diffusion potential has been emphasized. The experiments call attention to the effect of the thermodynamic properties of the membrane, and it is suggested that such properties as conductivities, ionic mobilities, and distribution coefficients in membranes of any sort should be investigated. The experiments afford an interesting example of "phase reversal."
Murray
C D
CD
Department of Physiology, Columbia University, New York.