The effect of curculigoside on the expression of matrix metalloproteinase-1 in cultured human skin fibroblasts.
The dried rhizomes of Curculigo orchioides G. yielded two phenolic glycosides, curculigoside (1), orcinol-beta-D-glucoside (4), and two cycloartane saponins, curculigosaponin G (2), curculigosaponin I (3). The structures were determined using spectroscopic methods. Among these isolates, compound 1 exhibited potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts. In addition, it increased the level of Bcl-2 protein expression and decreased the level of Bax protein expression. Compound 4 was isolated from this plant for the first time.
Lee
Song-Yi
SY
College of Pharmacy, Chosun University, Gwangju, Korea.
Kim
Mi-Ran
MR
Choi
Hong Seok
HS
Moon
Hyung-In
HI
Chung
Jin Ho
JH
Lee
Dong Gun
DG
Woo
Eun-Rhan
ER
D001565:Benzoates / Q000302:isolation & purification / Q000494:pharmacology*; D015153:Blotting, Western; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D024042:Collagen Type I / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects* / Q000201:enzymology; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis; D061965:Matrix Metalloproteinase Inhibitors; D015394:Molecular Structure; D012867:Skin / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D015595:Skin Aging / Q000187:drug effects
D001565:Benzoates; D024042:Collagen Type I; D004791:Enzyme Inhibitors; D005960:Glucosides; D061965:Matrix Metalloproteinase Inhibitors; C477170:curculigoside; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1