title: 11C-meta-hydroxyephedrine defects persist despite functional improvement in hibernating myocardium.
abstract: BACKGROUND
  Regional cardiac sympathetic nerve dysfunction develops in hibernating myocardium and may play a role in its association with sudden cardiac death. Interventions to improve cardiac function (i.e., revascularization) improve survival, but the potential reversibility of sympathetic nerve dysfunction remains unclear.
  
  
  RESULTS
  Pigs (n = 11) were chronically instrumented with a proximal left anterior descending coronary artery (LAD) stenosis to produce hibernating myocardium. Prior to therapeutic interventions, there was LAD occlusion with collateral-dependent myocardium, reduced regional function (echocardiographic LAD wall-thickening 23% +/- 4% vs 83% +/- 6% in Remote, P < .001), and large defects in (11)C-meta-hydroxyephedrine (HED) PET (48% +/- 4% of LV area, 26% +/- 2% integrated reduction). Successful PCI or pravastatin therapy improved regional (LAD wall-thickening 23% +/- 4% to 42% +/- 6%, P < .05) and global LV function (fractional shortening 24% +/- 2% to 31% +/- 2%, P < .01), but did not alter regional HED uptake, retention, defect size, or defect severity.
  
  
  CONCLUSIONS
  Despite significant functional improvement of hibernating myocardium as a result of PCI or pravastatin therapy, there were no changes in HED defect size or severity. Thus, inhomogeneity in myocardial sympathetic innervation persisted, and the lack of plasticity suggests that even in the absence of significant infarction, structural rather than functional defects are responsible for reduced myocardial norepinephrine uptake in chronic ischemic heart disease.
authors.affiliation: VA Western New York Health Care System, University at Buffalo, Buffalo, NY, USA. jaf7@buffalo.edu
authors.forename: James A
authors.initials: JA
authors.lastname: Fallavollita
authors.forename: Michael D
authors.initials: MD
authors.lastname: Banas
authors.forename: Gen
authors.initials: G
authors.lastname: Suzuki
authors.forename: Robert A
authors.initials: RA
authors.lastname: deKemp
authors.forename: Munawwar
authors.initials: M
authors.lastname: Sajjad
authors.forename: John M
authors.initials: JM
authors.lastname: Canty
mesh_terms: D000818:Animals; D001342:Autonomic Nervous System Diseases / Q000150:complications* / Q000000981:diagnostic imaging* / Q000188:drug therapy; D004809:Ephedrine / Q000031:analogs & derivatives*; D017682:Myocardial Stunning / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013552:Swine; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; C065363:3-hydroxyephedrine; D004809:Ephedrine