title: Toxic epidermal necrolysis and agranulocytosis: rare adverse effects of ciprofloxacin.
abstract: Ciprofloxacin is one of the most commonly used antibacterial agents with relatively few side effects. Serious adverse reactions reported with ciprofloxacin are rare with an incidence of 0.6%. Recently we came across two rare adverse effects of ciprofloxacin, viz. toxic epidermal necrolysis and agranulocytosis. To our knowledge, a total of seven cases have been reported in the literature documenting an association between oral ciprofloxacin administration and toxic epidermal necrolysis. One case of granulocytopenia, four of pancytopenia and fifteen of leucopenia worldwide have been reported. With the use of ciprofloxacin becoming more and more widespread, these two rare but fatal complications of ciprofloxacin should be borne in mind.
authors.affiliation: Department of Skin and STD, K. M. C. Hospital, Attavar, Mangalore, India. gathaupadya@hotmail.com
authors.forename: Gatha M
authors.initials: GM
authors.lastname: Upadya
authors.forename: K
authors.initials: K
authors.lastname: Ruxana
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced* / Q000188:drug therapy; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007970:Leukopenia; D000077731:Meropenem; D009503:Neutropenia; D012307:Risk Factors; D018805:Sepsis / Q000188:drug therapy; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy / Q000209:etiology*; D013845:Thienamycins / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D013845:Thienamycins; D016179:Granulocyte Colony-Stimulating Factor; D002939:Ciprofloxacin; D000077731:Meropenem