title: [Preparation and in vitro release of ginkgo biloba extract sustained-release tablets].
abstract: OBJECTIVE
  To prepare ginkgo biloba extract (GBE) sustained-release tablets and observe its in vitro release profile.
  
  
  METHODS
  GBE sustained-release tablets were prepared by direct compression method using sodium carboxymethylcellulose (CMC-Na) and hydroxypropyl methylcellulose HPMC) as matrix excipients. Based on the result of single-factor selecting experiment, the formulations and preparation process were optimized through orthogonal design, and release difference of tablets was evaluated with similarity factor (f2).
  
  
  RESULTS
  The ratio of HPMC and CMC-Na, the viscosity of HPMC and the different types of the diluents had pronounced effect on the release of GBE sustained release tablets, although the hardness and weight difference of tablets did not show notable influences.
  
  
  CONCLUSIONS
  GBE sustained-release tablets that prepared by using the mixture of HPMC and CMC-Na display constant release profile in 12 h.
authors.affiliation: School of Pharmacy, Medical College of Soochow University, Suzhou 215123, China.
authors.forename: Qihua
authors.initials: Q
authors.lastname: Cui
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Zhu
authors.forename: Jinghao
authors.initials: J
authors.lastname: Cui
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D004355:Drug Stability; D020441:Ginkgo biloba / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D013607:Tablets / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D010936:Plant Extracts; D013607:Tablets