title: Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses.
abstract: Human leukocyte antigen (HLA) genes play a critical role in host immunity, including vaccine responses. HLA molecules present antigenic peptides to T cells and provide inhibitory signals to NK cells, and polymorphisms within HLA genes allow binding and presentation of a diverse array of self and foreign peptides. Heterozygosity across HLA alleles has been found to play a positive role in host defense for a variety of infections. Homozygosity within one or more HLA loci may restrict this epitope repertoire and limit T-cell responses to infection or vaccination. Here we report that homozygosity within the HLA DPB1 locus is associated with increased levels of rubella-specific IgG, an effect driven by a common allele DPB1*0401. We also show that homozygosity within different HLA class I and class II loci is correlated with variations (but not necessarily decreases) in interleukin (IL)-2, IL-5, and IL-10 secretion after rubella virus stimulation.
authors.affiliation: Mayo Clinic, Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Kennedy
authors.forename: Inna G
authors.initials: IG
authors.lastname: Ovsyannikova
authors.forename: Robert A
authors.initials: RA
authors.lastname: Vierkant
authors.forename: Robert M
authors.initials: RM
authors.lastname: Jacobson
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Poland
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D002648:Child; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006720:Homozygote; D006801:Humans; D007111:Immunity, Cellular / Q000235:genetics*; D056724:Immunity, Humoral / Q000235:genetics*; D008297:Male; D012411:Rubella Vaccine / Q000235:genetics* / Q000276:immunology*; D012412:Rubella virus / Q000276:immunology; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D016207:Cytokines; D006680:HLA Antigens; D012411:Rubella Vaccine