Delayed and prolonged coma after acute disulfiram overdose.
We report the case of a 35-year-old man presenting with a delayed and prolonged coma due to an intentional overdose with disulfiram without simultaneous alcohol ingestion. The clinical features--comprising a severe toxic encephalopathy with coma and convulsions, in combination with a quadriparesis outlasting the loss of consciousness--are summarized, and the physiopathology is reviewed.
Lemoyne
S
S
Dienst Intensieve Zorg, Sint-Augustinus, Wilrijk, Belgium.
Raemaekers
J
J
Daems
J
J
Heytens
L
L
D000328:Adult; D000427:Alcohol Deterrents / Q000493:pharmacokinetics / Q000506:poisoning*; D003128:Coma / Q000139:chemically induced*; D004221:Disulfiram / Q000493:pharmacokinetics / Q000506:poisoning*; D062787:Drug Overdose; D004827:Epilepsy / Q000139:chemically induced; D006801:Humans; D008297:Male; D020258:Neurotoxicity Syndromes / Q000209:etiology*
D000427:Alcohol Deterrents; D004221:Disulfiram