title: [Surgery of thyroid carcinoma].
abstract: The 5 main types of thyroid cancer (papillary, PTC, follicular, FTC, poorly differentiated, PDTC undifferentiated, UTC, medullary, MTC) not only differ regarding morphology, pathogenesis, genetics,and pathophysiology (iodine metabolism, thyroglobulin and calcitonin production), but also concerning tumor biology, metastatic behavior (lymphogenous, locally invasive and hematogenous routes) and prognosis. Knowledge of these features is the basis of the surgical concept of one or two-stage thyroidectomy, the exceptions and the concept of locoregional lymph node dissection. Lymph node surgery plays an important role in those cancers exhibiting mainly lymph node metastases (PTC, MTC) not only due to frequent recurrences but also due to its potential curative intent. Differentiated carcinomas may have an acceptable prognosis despite local invasion of the cervical aerodigestive system, thus resections are justified when technical prerequisites are given.
authors.affiliation: Universitätsklinik für Allgemein-, Viszeral- und Gefässchirurgie, Universitätsklinikum Halle (Saale), Medizinische Fakultät der Martin-Luther-Universität Halle-Wittenberg, 06097 Halle. henning.dralle@medizin.uni-halle.de
authors.forename: H
authors.initials: H
authors.lastname: Dralle
authors.forename: K
authors.initials: K
authors.lastname: Lorenz
authors.forename: A
authors.initials: A
authors.lastname: Machens
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000465:Algorithms; D014408:Biomarkers, Tumor / Q000097:blood; D002116:Calcitonin / Q000097:blood; D002277:Carcinoma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D018276:Carcinoma, Medullary / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods*; D008207:Lymphatic Metastasis / Q000473:pathology; D008866:Microsurgery / Q000379:methods; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D012086:Reoperation; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy / Q000379:methods*; D014132:Trachea / Q000473:pathology / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D002116:Calcitonin