title: Evaluation of the persistent activity of moxidectin (10%) long-acting (LA) injectable formulation against Dictyocaulus viviparus, Haemonchus placei, Trichostrongylus axei and Oesophagostomum radiatum infections in cattle.
abstract: Two controlled studies were conducted to evaluate the persistent efficacy of moxidectin (10%) long-acting (LA) injectable formulation against Dictyocaulus viviparus, Haemonchus placei, Trichostrongylus axei and Oesophagostomum radiatum in cattle. The moxidectin LA injectable formulation was administered as a single subcutaneous injection into the proximal third of the ear at a dose rate of 0.01ml/kg BW to provide 1.0mg moxidectin/kg BW. The product had persistent efficacy of >90% against D. viviparus, H. placei and Oe. radiatum for at least 150 days post-treatment and against T. axei for at least 90 days post-treatment.
authors.affiliation: Fort Dodge Animal Health, P.O. Box 5366, Princeton, NJ 08543, USA. ranjans@pt.fdah.com
authors.forename: S
authors.initials: S
authors.lastname: Ranjan
authors.forename: R
authors.initials: R
authors.lastname: Search
authors.forename: E
authors.initials: E
authors.lastname: Szewczyk
authors.forename: D
authors.initials: D
authors.lastname: Amodie
authors.forename: R
authors.initials: R
authors.lastname: Pollet
authors.forename: D
authors.initials: D
authors.lastname: Rugg
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000469:parasitology*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005243:Feces / Q000469:parasitology; D005260:Female; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D008174:Lung Diseases, Parasitic / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary; D018942:Macrolides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D009348:Nematoda / Q000254:growth & development*; D009349:Nematode Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D009515:New Jersey; D010270:Parasite Egg Count / Q000662:veterinary; D011897:Random Allocation; D018709:Statistics, Nonparametric
chemical_list: D000969:Antinematodal Agents; D003692:Delayed-Action Preparations; D018942:Macrolides; C027837:moxidectin