title: A clustering of immune-mediated polyradiculoneuropathy among swine abattoir workers exposed to aerosolized porcine brains, Indiana, United States.
abstract: In November 2007 a novel neuropathy, immune-mediated polyradiculoneuropathy (IP), was identified among workers at a Minnesota swine abattoir where a unique compressed air technique was used to remove porcine brains. An epidemiologic investigation at another abattoir in Indiana that also uses this process was launched to evaluate workers self-reporting neurologic illness compatible with IP. A nested case-control study was performed to identify cases and risk factors. Six confirmed, one probable, and three possible IP cases were detected. IP cases were 28-52 years old, of Latino origin, and 62.5% female. Onset dates ranged from April 2005-December 2007; 60% were hospitalized. IP cases at this plant were similar in clinical presentation and exposure risks to those detected in Minnesota. Swine abattoirs using similar brain extraction methods should discontinue this process.
authors.affiliation: US Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333, USA. jadjemian@bop.gov
authors.forename: Jennifer Zipser
authors.initials: JZ
authors.lastname: Adjemian
authors.forename: James
authors.initials: J
authors.lastname: Howell
authors.forename: Stacy
authors.initials: S
authors.lastname: Holzbauer
authors.forename: Julie
authors.initials: J
authors.lastname: Harris
authors.forename: Sergio
authors.initials: S
authors.lastname: Recuenco
authors.forename: Jennifer
authors.initials: J
authors.lastname: McQuiston
authors.forename: Thomas
authors.initials: T
authors.lastname: Chester
authors.forename: Ruth
authors.initials: R
authors.lastname: Lynfield
authors.forename: Aaron
authors.initials: A
authors.lastname: Devries
authors.forename: Ermias
authors.initials: E
authors.lastname: Belay
authors.forename: Jim
authors.initials: J
authors.lastname: Sejvar
mesh_terms: D000003:Abattoirs; D000328:Adult; D000336:Aerosols / Q000009:adverse effects*; D000818:Animals; D001921:Brain; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007196:Indiana; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology*; D016273:Occupational Exposure; D011129:Polyradiculoneuropathy / Q000209:etiology* / Q000276:immunology; D034421:Sus scrofa
chemical_list: D000336:Aerosols