title: Association of an intronic variant of the heme oxygenase-1 gene with hypertension in northern Chinese Han population.
abstract: Heme oxygenase was regarded as a regulator of oxidative stress, which was believed to underlie the etiology of hypertension. To assess the effect of its encoded genes (HMOX1 and HMOX2) on hypertension, we designed a case-control study in 503 cases and 490 controls. The results indicated that the rs9607267 of the HMOX1 gene was significantly associated with essential hypertension (EH) and the Hap3(T-C-G) of the HMOX1 gene was also significantly associated with the risk of EH. No association was observed between the HMOX2 gene and EH. The multifactor-dimensionality reduction analyses results did not show any interaction between the HMOX1 and HMOX2 genes underlying the development of hypertension.
authors.affiliation: Department of Evidence-Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Yun
authors.forename: Liu
authors.initials: L
authors.lastname: Xiaoli
authors.forename: Zhao
authors.initials: Z
authors.lastname: Qi
authors.forename: Wang
authors.initials: W
authors.lastname: Laiyuan
authors.forename: Lu
authors.initials: L
authors.lastname: Xiangfeng
authors.forename: Shen
authors.initials: S
authors.lastname: Chong
authors.forename: Huang
authors.initials: H
authors.lastname: Jianfeng
authors.forename: Chen
authors.initials: C
authors.lastname: Shufeng
authors.forename: Li
authors.initials: L
authors.lastname: Hongfan
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Gu
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D016022:Case-Control Studies; D002681:China; D017931:DNA Primers / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D006239:Haplotypes; D006419:Heme Oxygenase (Decyclizing) / Q000235:genetics; D051547:Heme Oxygenase-1 / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000209:etiology / Q000235:genetics*; D007438:Introns; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D017931:DNA Primers; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1; C105245:heme oxygenase-2