Circulating tumor cells and individualized chemotherapy.
Circulating tumor cells (CTC) have been identified in peripheral blood from cancer patients especially those with metastatic lesions. Recently, the analysis of CTC has been developed rapidly and showed good prospects for individualized chemotherapy. The field of CTC research is very important since gene-expression profiling becomes feasible and real time when using CTC as the sample of evaluation. This review was to summarize present CTC detection, enrichment, or both methods and their contribution to individualized chemotherapy.
Yu
Shao-Rong
SR
The Cancer Center, The Affiliated Drum Tower Hospital, Medical School of Nanjing University Clinical Cancer Institute of Nanjing University, Jiangsu, P. R. China.
Wei
Jia
J
Qian
Xiao-Ping
XP
Liu
Bao-Rui
BR
D002469:Cell Separation / Q000379:methods*; D048429:Cell Size; D002499:Centrifugation, Density Gradient; D016503:Drug Delivery Systems; D006801:Humans; D018189:Immunomagnetic Separation; D046228:Microarray Analysis; D009369:Neoplasms / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D009360:Neoplastic Cells, Circulating / Q000378:metabolism / Q000473:pathology*