Self-generated theta oscillations in the hippocampus.
Hippocampal theta rhythm is crucial for spatial memory and is thought to be generated by extrinsic inputs. In contrast, using a complete rat hippocampus in vitro, we found several intrinsic, atropine-resistant theta generators in CA1. These oscillators were organized along the septotemporal axis and arose independently from CA3. Our results suggest that CA1 theta rhythm can emerge from the coupling of multiple autonomous hippocampal theta oscillators.
Goutagny
Romain
R
Douglas Mental Health University Institute, McGill University, Department of Psychiatry, Québec, Canada.
Jackson
Jesse
J
Williams
Sylvain
S
D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000502:physiology*; D056654:CA3 Region, Hippocampal / Q000166:cytology / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D007395:Interneurons / Q000166:cytology / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D010507:Periodicity; D017966:Pyramidal Cells / Q000502:physiology*; D051381:Rats; D013569:Synapses / Q000502:physiology; D013826:Theta Rhythm