Interferons and their potential in the treatment of ocular inflammation.
Since their discovery in the 1950s interferons have been the scope of investigation in many diseases as therapeutic as well as pathogenetic factors. We know they have immune stimulatory and immune regulatory effects. This apparently counter-intuitive mechanism can be summarized as immunomodulatory action and seems to be very effective in a number of ocular inflammatory diseases. We review the current knowledge of interferons in immunity and autoimmunity and show their use in clinical ophthalmologic practice.
Mackensen
Friederike
F
Interdisciplinary Uveitis Center, Dept. of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany. friederike.mackensen@uveitiszentrum.de
Max
Regina
R
Becker
Matthias D
MD