Impact of plasmatic lipids in glycemic control and its influence in the cardiometabolic risk in morbidly obese subjects.
OBJECTIVE
To evaluate whether biochemical parameters are associated with a good glycemic control and to identify the occurrence of cardiometabolic risk variables.


METHODS
One hundred forty Brazilians were evaluated. The subjects were characterized with regard to glycemic control as good, fair and poor and were divided into tertiles by TG and HbA(1c). We use the ROC curve to determine which variables were predicted of poor glycemic control and the factor analyses to identify the domains that segregated among the risk variables.


RESULTS
Fasting glucose and insulin levels, TG level, VLDL-C and HOMA-IR increased significantly across HbA(1c) tertiles. The best marker for identification of poor glycemic control was triglycerides. The presence of cardiometabolic abnormalities did not alter the glycemic control, but HOMA-IR was significantly higher in subjects with abnormalities.


CONCLUSIONS
The use of TG levels offers a reasonable degree of clinical utility. In morbidly obese subjects insulin resistance is associated with individual cardiometabolic factors.
Serpa Neto
Ary
A
Faculdade de Medicina do ABC, Santo André, SP, Brasil.
Rossi
Felipe Martin Bianco
FM
Amarante
Rodrigo Dal Moro
RD
Buriti
Nara Alves
NA
Rossi
Marçal
M
D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology; D015243:Cholesterol, VLDL / Q000097:blood; D005215:Fasting / Q000097:blood; D005260:Female; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000209:etiology; D009767:Obesity, Morbid / Q000097:blood* / Q000150:complications; D012372:ROC Curve; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D001786:Blood Glucose; D015243:Cholesterol, VLDL; D007328:Insulin; D008055:Lipids; D014280:Triglycerides