Cohesin: its roles and mechanisms.
The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-break repair and transcriptional control. The functions of cohesin are regulated by phosphorylation, acetylation, ATP hydrolysis, and site-specific proteolysis. Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits.
Nasmyth
Kim
K
Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom. kim.nasmyth@bioch.ox.ac.uk
Haering
Christian H
CH
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D002875:Chromosomes / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D000097722:Cohesins
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004247:DNA; D000097722:Cohesins