Clinical research of compound zhebei granules for increasing the therapeutic effect of chemotherapy in refractory acute leukemia patients.
OBJECTIVE
To observe the effects of Compound Zhebei Granules (CZG) in chemotherapy for refractory acute leukemia.


METHODS
Using a randomized, double-blind and multi-central concurrent control clinical research project, the patients conformed with the diagnostic criteria, according to the drug randomized method, were divided into a CZG group and a control group. The patients of the two groups respectively took the observation drug or a placebo 3 days before chemotherapy, and the therapeutic effects were evaluated after one course of chemotherapy. According to the clinical research project, 137 patients were enrolled, including 71 cases in the CZG group and 66 cases in the control group.


RESULTS
The clinical complete remission (CR) rate was 42.3% in the CZG group with a total effective rate of 73.2%, and it was 25.8% in the control group with a total effective rate of 53.0%, showing a statistically significant difference between the two groups (P < 0.05).


CONCLUSIONS
CZG can increase the clinical remission rate for refractory acute leukemia during chemotherapy.
Lu
Dian-Rong
DR
Department of Oncology and Hematology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
Li
Dong-Yun
DY
Chen
Xin-Yi
XY
Ye
Pei-Zhi
PZ
Tian
Shao-Dan
SD
D000208:Acute Disease; D000328:Adult; D016009:Chi-Square Distribution; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D007951:Leukemia, Myeloid / Q000188:drug therapy; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D012074:Remission Induction; D016896:Treatment Outcome; D055815:Young Adult