title: DRYGIN: a database of quantitative genetic interaction networks in yeast.
abstract: Genetic interactions are highly informative for deciphering the underlying functional principles that govern how genes control cell processes. Recent developments in Synthetic Genetic Array (SGA) analysis enable the mapping of quantitative genetic interactions on a genome-wide scale. To facilitate access to this resource, which will ultimately represent a complete genetic interaction network for a eukaryotic cell, we developed DRYGIN (Data Repository of Yeast Genetic Interactions)-a web database system that aims at providing a central platform for yeast genetic network analysis and visualization. In addition to providing an interface for searching the SGA genetic interactions, DRYGIN also integrates other data sources, in order to associate the genetic interactions with pathway information, protein complexes, other binary genetic and physical interactions, and Gene Ontology functional annotation. DRYGIN version 1.0 currently holds more than 5.4 million measurements of genetic interacting pairs involving approximately 4500 genes, and is available at http://drygin.ccbr.utoronto.ca.
authors.affiliation: Banting and Best Department of Medical Research, The Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON, Canada. judice.koh@utoronto.ca
authors.forename: Judice L Y
authors.initials: JL
authors.lastname: Koh
authors.forename: Huiming
authors.initials: H
authors.lastname: Ding
authors.forename: Michael
authors.initials: M
authors.lastname: Costanzo
authors.forename: Anastasia
authors.initials: A
authors.lastname: Baryshnikova
authors.forename: Kiana
authors.initials: K
authors.lastname: Toufighi
authors.forename: Gary D
authors.initials: GD
authors.lastname: Bader
authors.forename: Chad L
authors.initials: CL
authors.lastname: Myers
authors.forename: Brenda J
authors.initials: BJ
authors.lastname: Andrews
authors.forename: Charles
authors.initials: C
authors.lastname: Boone
mesh_terms: D019295:Computational Biology / Q000379:methods* / Q000639:trends; D030541:Databases, Genetic; D030561:Databases, Nucleic Acid; D030562:Databases, Protein; D005656:Fungal Proteins / Q000235:genetics; D005800:Genes, Fungal; D016681:Genome, Fungal; D016247:Information Storage and Retrieval / Q000379:methods; D020407:Internet; D008957:Models, Genetic; D025941:Protein Interaction Mapping; D017434:Protein Structure, Tertiary; D012984:Software
chemical_list: D005656:Fungal Proteins