[Perioperative antibiotics effectiveness on conjunctival flora and microbial sensitivity].
OBJECTIVE
To compare the affect upon bacterial flora found in the conjunctival sacs and the microbial sensitivity of a gatifloxacin (GFLX) ophthalmic solution prospectively with two instillation method groups.


METHODS
In one group (group A) GFLX solution was instilled postoperatively eight times/day for 2 days and subsequently four times/day for 12 days. In the other group (group B) the solution was instilled four times/day for 28 days. We investigated bacterial flora in the conjunctival sacs of patients who were to undergo cataract surgery, and tested for microbial sensitivity.


RESULTS
There was no significant difference in the detection rate of bacterial flora in the conjunctival sacs. One bacterial isolate resistant to LVFX was identified in group A, and one resistant to GFLX and LVFX in group B.


CONCLUSIONS
There is a possibility that the application of topical antibiotics may have little influence on positive culture. However, the occurrence of a resistance to GFLX indicates that the aimless use of antibiotics should be avoided during ophthalmic perioperative periods.
Arakaki
Yoshikuni
Y
Department of Clinical Neuroscience, Visual Function and Science, University of the Ryukyus, Faculty of Medicine, Okinawa-ken, Japan. yoshikuni-arakaki@earth.ocn.ne.jp
Hayakawa
Kazuhisa
K
Mori
Fumihiko
F
Kojima
Masahiro
M
Masahara
Hidetaka
H
Matsushita
Tomohiro
T
Mori
Yosai
Y
Eguchi
Shuichiro
S
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D019072:Antibiotic Prophylaxis; D001419:Bacteria / Q000187:drug effects*; D003228:Conjunctiva / Q000382:microbiology*; D024841:Fluoroquinolones / Q000008:administration & dosage* / Q000494:pharmacology*; D000077734:Gatifloxacin; D006801:Humans; D008826:Microbial Sensitivity Tests; D019990:Perioperative Care
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D000077734:Gatifloxacin