Cytotoxic effect of flavonoids on leukemia cells and normal cells of human blood.
We compared the cytotoxic effect of 11 flavonoids on chronic myeloid leukemia (erythroblast crisis) K562 cells and peripheral blood mononuclear cells from healthy donors. Baicalein and myricetin had a specific cytotoxic effect on leukemia cells.
Romanouskaya
T V
TV
Belarussian State University, Minsk, Belarussia. romanovskaya.t@mail.ru
Grinev
V V
VV
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D020014:K562 Cells; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*
D000970:Antineoplastic Agents; D005419:Flavonoids