title: Efficacy of 308-nm excimer light for Japanese patients with psoriasis.
abstract: Ultraviolet irradiation therapy, including psoralen and ultraviolet A therapy and narrow-band ultraviolet B (310-312 nm) therapy, is a widely used and highly efficient treatment modality for psoriasis. Therapy with 308-nm excimer light has been reported to be effective for the treatment of psoriasis vulgaris. To evaluate the efficacy of 308-nm excimer light therapy for Japanese psoriasis patients, seven patients (six men and one woman) with plaque-type psoriasis were treated with 308-nm excimer light at 7-14-day intervals. The Psoriasis Severity Index (PSI) was calculated for individual plaques in order to assess the effectiveness of the therapy. A 74.9% mean improvement in the PSI was observed after 10 treatment sessions. These results suggested that targeted irradiation with 308-nm excimer light leads to rapid and selective improvement in plaque-type psoriatic lesions without unnecessary radiation exposure to the surrounding unaffected skin.
authors.affiliation: Department of Dermatology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan. niwa-yu@juntendo.ac.jp
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Niwa
authors.forename: Toshio
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Subin
authors.initials: S
authors.lastname: Ko
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Okuyama
authors.forename: Akiko
authors.initials: A
authors.lastname: Ohtsuki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takagi
authors.forename: Shigaku
authors.initials: S
authors.lastname: Ikeda
mesh_terms: D000328:Adult; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000175:diagnosis / Q000532:radiotherapy*; D011788:Quality of Life; D011879:Radiotherapy Dosage; D012494:Sampling Studies; D012720:Severity of Illness Index; D012867:Skin / Q000528:radiation effects*; D016896:Treatment Outcome; D014466:Ultraviolet Rays; D014467:Ultraviolet Therapy / Q000379:methods*