title: Association between retinol-binding protein 4 concentrations and gestational diabetes mellitus and risk of developing metabolic syndrome after pregnancy.
abstract: The aim of this study was to examine the association between plasma retinol-binding protein 4 (RBP4) and gestational diabetes mellitus (GDM) and the risk of developing metabolic syndrome after pregnancy. In a case-control study, 192 pregnant women (92 with GDM) were recruited. Gestational diabetes mellitus was diagnosed based on O'Sullivan and Mahan criteria. In all pregnancies, plasma RBP4 concentrations were measured. Retinol-binding protein 4 concentrations in GDM patients were significantly higher than the normal women. Retinol-binding protein 4 level equal to or more than 42 microg/mL could help predict the risk of developing GDM (sensitivity = 75.8%, specificity = 65.3%, P = .001). Concerning metabolic syndrome after pregnancy, in all participants, the prevalence of metabolic syndrome base on World Health Organization (WHO) criteria was 24%. After pregnancy, 32.6% of women with GDM had metabolic syndrome compared with 10.5% of those with healthy pregnancy (P = .001). Age more than 25 years, body mass index (BMI) more than 27 kg/cm(2), and RBP4 concentrations were independent risk factors for GDM. Measurement of RBP4 together with the assessment of other risk factors could help identify women at risk of developing GDM.
authors.affiliation: Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Zhila
authors.initials: Z
authors.lastname: Maghbooli
authors.forename: Arash
authors.initials: A
authors.lastname: Hossein-Nezhad
authors.forename: Khadijeh
authors.initials: K
authors.lastname: Mirzaei
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Karimi
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Besharati
authors.forename: Kobra
authors.initials: K
authors.lastname: Omidfar
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D011247:Pregnancy; D015995:Prevalence; D012044:Regression Analysis; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma