title: Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis.
abstract: In this study, a simplified spherical harmonics approximated higher order diffusion model is employed for 3-D diffuse optical tomography of osteoarthritis in the finger joints. We find that the use of a higher-order diffusion model in a stand-alone framework provides significant improvement in reconstruction accuracy over the diffusion approximation model. However, we also find that this is not the case in the image-guided setting when spatial prior knowledge from x-rays is incorporated. The results show that the reconstruction error between these two models is about 15 and 4%, respectively, for stand-alone and image-guided frameworks.
authors.affiliation: University of Florida, Department of Biomedical Engineering, 130 BME Building, P.O. Box 116131, Gainesville, Florida 32611-6131, USA.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yuan
authors.forename: Qizhi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Eric
authors.initials: E
authors.lastname: Sobel
authors.forename: Huabei
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008954:Models, Biological; D010003:Osteoarthritis / Q000473:pathology*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity