title: [A case of rapidly progressing lung spindle cell carcinoma presenting as Pancoast syndrome].
abstract: We report a case of rapidly progressing spindle cell carcinoma presenting as Pancoast syndrome. The patient was a 59-year-old woman with a chief complaint of right forearm paresthesia. A chest computed tomography revealed a huge tumor in S1 and S2 in the right lung, invading the upper mediastinum and the first rib. A CT-guided lung biopsy was performed. H-E stain of the tissue revealed spindle-shaped tumor cells proliferating diffusely in a streaming pattern without definitive squamous or glandular differentiation. Immunohistochemical stains with CAM 5.2 and vimentin were positive for tumor cells. Based on a pathological diagnosis of spindle cell carcinoma (cT4N3M1, stage IV) she was treated with chemoradiotherapy. Despite treatment, the patient died 6 months after presenting.
authors.affiliation: Department of Integrated Medicine, Toyota Memorial Hospital.
authors.forename: Naoki
authors.initials: N
authors.lastname: Misumida
authors.forename: Ryo
authors.initials: R
authors.lastname: Sanda
authors.forename: Akiko
authors.initials: A
authors.lastname: Ota
authors.forename: Motoaki
authors.initials: M
authors.lastname: Kato
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Takagi
authors.forename: Ayako
authors.initials: A
authors.lastname: Yagi
authors.forename: Yasuteru
authors.initials: Y
authors.lastname: Sugino
authors.forename: Michiko
authors.initials: M
authors.lastname: Fujii
authors.forename: Yushi
authors.initials: Y
authors.lastname: Saitou
mesh_terms: D002277:Carcinoma / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology; D010178:Pancoast Syndrome / Q000209:etiology*