title: Granatumins A-G, limonoids from the seeds of a Krishna mangrove, Xylocarpus granatum.
abstract: Seven new limonoids (1-7), named granatumins A-G, were isolated from seeds of an Indian mangrove (Xylocarpus granatum) collected from the wetlands of Krishna estuary, Andhra Pradesh. The known compounds khayasin T, tigloylseneganolide A, 6-deoxyswietenine, swietemahonolide, febrifugin A, gedunin, xylogranatinin, phaseic acid, (2R,3R)-3,4',5,7-tetrahydroxyflavanone, and (E)-4-hydroxycinnamic acid were also isolated. The structures were established on the basis of spectroscopic data. Granatumins A and B are mexicanolides with endo-conjugated Delta(8,30) and Delta(14,15) double bonds, and granatumins F and G are polyhydroxylated phragmalins found previously in plants of the Meliaceae. Khayasin T exhibited moderate insecticidal activity against fifth instar larvae of Brontispa longissima (Gestro) at a concentration of 20 mg/L.
authors.affiliation: Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
authors.forename: Min-Yi
authors.initials: MY
authors.lastname: Li
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Yang
authors.forename: Jian-Yu
authors.initials: JY
authors.lastname: Pan
authors.forename: Gang
authors.initials: G
authors.lastname: Feng
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xiao
authors.forename: Jari
authors.initials: J
authors.lastname: Sinkkonen
authors.forename: Tirumani
authors.initials: T
authors.lastname: Satyanandamurty
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
mesh_terms: D000818:Animals; D003059:Cocos / Q000469:parasitology; D001517:Coleoptera / Q000187:drug effects; D006801:Humans; D007194:India; D007814:Larva / Q000187:drug effects; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010935:Plant Diseases / Q000469:parasitology; D012639:Seeds / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D036701:Limonins