Spindle cell/pleomorphic lipoma of the oral cavity.
We herein report a rare case of a lipomatous tumor of the buccal mucosa, showing intermediate morphological features between spindle cell and pleomorphic lipomas, for which the term spindle cell/pleomorphic lipoma is proposed. The presence of multinucleated floretlike cells may pose differential diagnostic problems, especially with spindle cell variant of well-differentiated liposarcoma. Morphological features helpful in the distinction between these tumors are emphasized. Although androgen receptors have been documented in most spindle cell lipomas, suggesting a potential pathogenetic role of sex steroid hormones, no immunoreactivity for androgen, estrogen, and progesterone receptors was obtained in our case. These findings would suggest a different pathogenetic pathway in spindle cell/pleomorphic lipoma of the oral cavity.
Vecchio
Giada
G
Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Catania, Italy.
Amico
Paolo
P
Caltabiano
Rosario
R
Colella
Giuseppe
G
Lanzafame
Salvatore
S
Magro
Gaetano
G
D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008067:Lipoma / Q000473:pathology*; D008080:Liposarcoma / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000473:pathology*; D011944:Receptors, Androgen / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis
D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone