Highly stereoselective hydrogenations--as key-steps in the total synthesis of statins.
Statins are inhibitors of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMG-CoA reductase) and became the standard of care for treatment of hypercholesterolemia because of their efficacy, safety, and long-term benefits. They are administered as diastereo- and enantiomerically pure compounds. We summarize here two new approaches for the total synthesis of the most important representatives, atorvastatin, and rosuvastatin, based on highly stereoselective hydrogenations as key-steps.
Andrushko
Natalia
N
Leibniz-Institut für Katalyse an der Universität Rostock e.V., 18059, Rostock, Germany.
Andrushko
Vasyl
V
Tararov
Vitali
V
Korostylev
Andrei
A
König
Gerd
G
Börner
Armin
A
D000069059:Atorvastatin; D005464:Fluorobenzenes / Q000138:chemical synthesis / Q000737:chemistry; D006538:Heptanoic Acids / Q000138:chemical synthesis / Q000737:chemistry; D006865:Hydrogenation; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry; D000068718:Rosuvastatin Calcium; D013237:Stereoisomerism; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry
D005464:Fluorobenzenes; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011743:Pyrimidines; D011758:Pyrroles; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium; D000069059:Atorvastatin