title: CHEMICAL STUDIES ON BACTERIAL AGGLUTINATION : VII. A QUANTITATIVE STUDY OF THE TYPE SPECIFIC AND GROUP SPECIFIC ANTIBODIES IN ANTIMENINGOCOCCAL SERA OF VARIOUS SPECIES AND THEIR RELATION TO MOUSE PROTECTION.
abstract: 1. The quantitative method for the estimation of agglutinins has been applied to antimeningococcal horse, rabbit, and chicken sera and to the sera of humans convalescing from meningococcus meningitis. The type-specific and group-specific agglutinin N can be measured, using homologous and heterologous suspensions of meningococci. 2. Type I horse, rabbit, and chicken antimeningococcal sera contain considerable amounts of antibody which cannot be removed either by Type II meningococcus suspension or by preparations of the Type I specific polysaccharide. This residual type-specific antibody has marked potency in protecting mice against subsequent infection with meningococci. 3. Most human convalescent sera contain group-specific antibody. Small amounts of protective antibody and of antipolysaccharide are also formed. 4. Type I antisera absorbed with Type I polysaccharide and with Type II meningococci could be used as a guide in the purification of this new antigen.
authors.affiliation: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, the Neurological Institute of New York, and the Department of Medicine, The University of Chicago.
authors.forename: E A
authors.initials: EA
authors.lastname: Kabat
authors.forename: C P
authors.initials: CP
authors.lastname: Miller
authors.forename: H
authors.initials: H
authors.lastname: Kaiser
authors.forename: A Z
authors.initials: AZ
authors.lastname: Foster