Lewis base-catalyzed three-component Strecker reaction on water. An efficient manifold for the direct alpha-cyanoamination of ketones and aldehydes.
The first three-component organocatalyzed Strecker reaction operating on water has been developed. The manifold utilizes ketones (aldehydes) as the starting carbonyl component, aniline as the primary amine, acetyl cyanide as the cyanide source and N,N-dimethylcyclohexylamine as the catalyst.
Cruz-Acosta
Fabio
F
Department of Química Biológica y Biotecnología, Instituto de Productos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas, Astrofísico Francisco Sánchez 3, 38206 La Laguna-Tenerife, Spain.
Santos-Expósito
Alicia
A
de Armas
Pedro
P
García-Tellado
Fernando
F
D000447:Aldehydes / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D000447:Aldehydes; D003486:Cyanides; D007659:Ketones; D014867:Water