Why T waves change: a reminiscence and essay.
The following article is a personal reflection on my study of a subject which has long interested me. The subject is the T wave, and especially the T wave changes occurring as a marker of cardiac memory. My interest evolved over coffees that Mauricio Rosenbaum and I used to share at the Hotel Algonquin during his frequent trips from Buenos Aires to New York. There is something about the Algonquin, whose scarred wooden tabletops carry the imprints of Robert Benchley, Dorothy Parker, and the 1920's New York literati, and there was something about Mauricio-clinician-scientist, friend, and raconteur extraordinaire-that made his repeated challenges to me to "look at cardiac memory before you begin losing your own" irresistible. So began my personal voyage into trying to understand the T wave. My guideposts were the experiments of Wilson and Finch,(1) the astute observations of a host of investigators who followed, and Mauricio's iconoclastic insights. The story is far from over...I doubt I'll see the end of it in my lifetime. But if the beauty of discovery is in the voyage, then it has been - for me - a memorable trip.
Rosen
Michael R
MR
Department of Pharmacology, Center for Molecular Therapeutics, and Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. mrr1@columbia.edu
D000200:Action Potentials; D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D022062:Electrophysiologic Techniques, Cardiac; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000502:physiology
D007473:Ion Channels; D000804:Angiotensin II