Antiproliferative activity of Korean wild vegetables on different human tumor cell lines.
This study was conducted to determine the antiproliferative activity of 24 Korean wild vegetables. The methanol extracts of these wild vegetables were used against lung, breast, colon and gastric cancer cells, and the results were assessed by MTT assay. It was found that at the extract concentration of 400 mgL(-1) 14 plants exercised antiproliferative activity over 80% against the lung cancer cells, one plant among six--against breast cancer cells, and two plants among six--against colon cancer cells, respectively. Eighteen wild vegetables had the hyperplasia inhibition activity against gastric cancer cells over 23.6% at all extract concentrations, however, only six plants had the antiproliferative activity over 80% in 600 mgL(-1). It was found that the extracts from Youngia sonchifolia, Synurus deltoides, Syneilesis palmata, and Cephalonoplos segetum, in concentration of 400 mgL(-1) inhibited the hyperplasia of lung cancer cells over 95% and Angelica gigas-both lung and colon cancer cells over 95%. In conclusion, the studied wild vegetables' methanol extracts possess dose dependent antiproliferative properties, based on their bioactive compounds, mainly polyphenols, but some of them as Hypericum ascyron against lung cancer are not effective and even course harm.
Heo
Buk-Gu
BG
Naju Foundation of Natural Dyeing Culture, Naju 520-931, South Korea.
Chon
Sang-Uk
SU
Park
Yun-Jum
YJ
Bae
Jong-Hyang
JH
Park
Su-Min
SM
Park
Yong-Seo
YS
Jang
Hong-Gi
HG
Gorinstein
Shela
S
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006965:Hyperplasia / Q000517:prevention & control; D007723:Korea; D019684:Magnoliopsida; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology* / Q000627:therapeutic use; D014675:Vegetables
D000972:Antineoplastic Agents, Phytogenic; D028321:Plant Preparations