title: Lewis base-catalyzed three-component Strecker reaction on water. An efficient manifold for the direct alpha-cyanoamination of ketones and aldehydes.
abstract: The first three-component organocatalyzed Strecker reaction operating on water has been developed. The manifold utilizes ketones (aldehydes) as the starting carbonyl component, aniline as the primary amine, acetyl cyanide as the cyanide source and N,N-dimethylcyclohexylamine as the catalyst.
authors.affiliation: Department of Química Biológica y Biotecnología, Instituto de Productos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas, Astrofísico Francisco Sánchez 3, 38206 La Laguna-Tenerife, Spain.
authors.forename: Fabio
authors.initials: F
authors.lastname: Cruz-Acosta
authors.forename: Alicia
authors.initials: A
authors.lastname: Santos-Expósito
authors.forename: Pedro
authors.initials: P
authors.lastname: de Armas
authors.forename: Fernando
authors.initials: F
authors.lastname: García-Tellado
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D003486:Cyanides; D007659:Ketones; D014867:Water