New era for personalized medicine: the diagnosis and management of age-related macular degeneration.
It can be argued that age-related macular degeneration is one of the best characterized complex trait diseases. Extensive information related to genetic and environmental risk factors exists, and a number of different biological pathways are strongly implicated in its aetiology. Along with recent improvements in high throughput and relatively inexpensive genetic technologies, we are now in a position to consider developing a presymptomatic, personalized approach towards the assessment, management and treatment of this disease. We explore the applicability and challenges of this approach if it is to become commonplace for guiding treatment decisions for individuals with pre-existing disease or for those at high risk of developing it.
Baird
Paul N
PN
Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia. pnb@unimelb.edu.au
Hageman
Gregory S
GS
Guymer
Robyn H
RH
D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D008268:Macular Degeneration / Q000453:epidemiology / Q000235:genetics* / Q000628:therapy*; D020641:Polymorphism, Single Nucleotide; D057285:Precision Medicine / Q000639:trends*; D012307:Risk Factors