The effect of a fortified milk drink on vitamin D status and bone turnover in post-menopausal women from South East Asia.
Calcium and vitamin D are essential for bone growth; milk is an appropriate vehicle to be fortified with calcium, vitamin D and other minerals. The purpose of the current study was to compare the effect of supplementing with a high calcium milk drink with added vitamin D, magnesium and zinc (HCM) versus a placebo drink on serum parathyroid hormone (PTH) and vitamin D status as well as markers of bone formation/resorption in postmenopausal women living in South East Asia (Jakarta, Indonesia and Manila, the Philippines) over a period of 4 months. Calcium intake at baseline was 237 mg (median; 176-316, interquartile range) for Indonesia and 353 mg (median; 222-480, interquartile range) for the Filipino women per day. Fortified milk supplementation reduced the percentage of women that were insufficient in 25 (OH) vitamin D(3) (<50 nmol/L) from 70% to 22% in the Indonesian women and 20% to 0% in the Filipino women. Fortified milk supplementation significantly reduced parathyroid hormone levels (PTH) by week 2 (22% and 11%), C-telopeptide of type I collagen (CTX) by week 2 (34% and 27%), osteocalcin (OC) by week 8 (18% and 25%) and procollagen type I N-propeptide (PINP) by week 8 (15% and 21%), in women from Indonesia and the Philippines, respectively. Thus, the HCM intervention was able to significantly improve vitamin D status, lower PTH levels and reduce bone turnover in two groups of South East Asian women.
Kruger
Marlena C
MC
IFNHH, Massey University, Palmerston North, New Zealand. m.c.kruger@massey.ac.nz
Schollum
Linda M
LM
Kuhn-Sherlock
Barbara
B
Hestiantoro
Andon
A
Wijanto
Paulus
P
Li-Yu
Julie
J
Agdeppa
Imelda
I
Todd
Joanne M
JM
Eastell
Richard
R
D000818:Animals; D016723:Bone Remodeling / Q000502:physiology*; D005260:Female; D005527:Food, Fortified; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D008875:Middle Aged; D008892:Milk; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000178:diet therapy / Q000453:epidemiology; D010281:Parathyroid Hormone / Q000097:blood; D010679:Philippines / Q000453:epidemiology; D017698:Postmenopause / Q000097:blood; D014807:Vitamin D / Q000097:blood*
D010281:Parathyroid Hormone; D014807:Vitamin D