Effect of early physical activity on long-term outcome after venous thrombosis.
OBJECTIVE
To determine if the level of self-reported physical activity 1 month after deep vein thrombosis (DVT) is associated with the risk of post-thrombotic syndrome (PTS) in the first 2 years post-DVT.


METHODS
Prospective cohort study.


METHODS
Multicenter study (8 hospitals).


METHODS
Patients presenting with objectively diagnosed acute DVT to 8 hospitals in Quebec and Ontario, Canada.


METHODS
We used validated questionnaires to measure physical activity (Godin questionnaire) and venous disease severity [generic physical quality of life (SF-36 PCS scale) or VEINES-QOL]. We adjusted for potential confounding effects of age, sex, and body mass index. We used multiple imputation to account for missing data.


METHODS
Post-thrombotic syndrome (validated Villalta scale).


RESULTS
For the 387 patients enrolled, univariate analysis suggested no association between 1-month activity and risk of PTS. After adjusting for missing data and potential confounders, there was no evidence of a trend toward increasing risk of PTS with increasing physical activity [1.65 (95% confidence interval, 0.87-3.14) for mild-moderate activity and 1.35 (95% confidence interval, 0.69-2.67) for high activity]. The results were similar when PTS was dichotomized as none/mild versus moderate/severe. Finally, patients with PTS had lower levels of activity at 2 years post-DVT.


CONCLUSIONS
The level of self-reported exercise in the first month post-DVT is not associated with an increased risk of PTS in the first 2 years after DVT. Post-thrombotic syndrome is associated with decreased levels of physical activity 2 years after DVT.
Shrier
Ian
I
Centre for Clinical Epidemiology and Community Studies, Lady Davis Institute for Medical Research, SMBD-Jewish General Hospital, Montreal, Quebec, Canada. ian.shrier@mcgill.ca
Kahn
Susan R
SR
Steele
Russell J
RJ
D000368:Aged; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D054070:Postthrombotic Syndrome / Q000209:etiology; D011446:Prospective Studies; D012307:Risk Factors; D057185:Sedentary Behavior; D020246:Venous Thrombosis / Q000150:complications*