title: Obstructive sleep apnea is frequent in patients with hypertensive intracerebral hemorrhage and is related to perihematoma edema.
abstract: BACKGROUND
  Obstructive sleep apnea (OSA) is related to increased systemic inflammation and arterial hypertension. We hypothesize that OSA is frequent in patients with acute hypertensive intracerebral hemorrhage (ICH) and is related to the perihematoma edema.
  
  
  METHODS
  Thirty-two non-comatose patients with a hypertensive ICH underwent polysomnography in the acute phase. Perihematoma edema volume was measured on CT scans at admission, after 24 h (early control) and after 4-5 days (late control). The Spearman coefficient (r(s)) was used for correlations.
  
  
  RESULTS
  OSA occurred in 19 (59.4%) patients. The apnea-hypopnea index was correlated with relative edema at admission CT (r(s) = 0.40; p = 0.031), early CT (r(s) = 0.46; p = 0.011) and at late CT (r(s) = 0.59; p = 0.006).
  
  
  CONCLUSIONS
  OSA is highly frequent during the acute phase of hypertensive ICH and is related to perihematoma edema.
authors.affiliation: Department of Neuroscience and Behavior, Ribeirão Preto School of Medicine, University of São Paulo, São Paulo, Brazil. octaviopontes@rnp.fmrp.usp.br
authors.forename: Octavio M
authors.initials: OM
authors.lastname: Pontes-Neto
authors.forename: Regina M F
authors.initials: RM
authors.lastname: Fernandes
authors.forename: Heidi H
authors.initials: HH
authors.lastname: Sander
authors.forename: Larissa A T
authors.initials: LA
authors.lastname: da Silva
authors.forename: Débora C
authors.initials: DC
authors.lastname: Mariano
authors.forename: Fernando
authors.initials: F
authors.lastname: Nobre
authors.forename: Gustavo
authors.initials: G
authors.lastname: Simão
authors.forename: Draulio B
authors.initials: DB
authors.lastname: de Araujo
authors.forename: Antonio C
authors.initials: AC
authors.lastname: dos Santos
authors.forename: João P
authors.initials: JP
authors.lastname: Leite
mesh_terms: D000208:Acute Disease; D000368:Aged; D001929:Brain Edema / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D006406:Hematoma / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D020299:Intracranial Hemorrhage, Hypertensive / Q000150:complications* / Q000000981:diagnostic imaging; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D017286:Polysomnography; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000209:etiology*; D013997:Time Factors; D014057:Tomography, X-Ray Computed