Nonalbumin proteinuria in islet transplant recipients.
The aim of this study was to evaluate the importance of nonalbumin-predominant proteinuria on kidney function (KF) after islet transplantation (ITx). Twenty-four-hour proteinuria and albuminuria were available in 27 recipients. KF was assessed by serum creatinine and estimated glomerular filtration rate (eGFR) was calculated by Modification of Diet in Renal Disease formula. Correlations between eGFR and albuminuria (r = -0.422, p < 0.001) were higher than with proteinuria (r = -0.223, p < 0.001; p = 0.006 for comparison between correlations). Nineteen (70%) subjects had proteinuria >or= 300 mg/24 h during the follow-up. Subjects were divided into three groups according to urinary protein excretion patterns: no proteinuria (n = 8), nonalbumin-predominant (n = 8), and albumin-predominant (n = 11) proteinuria. Proteinuria >or= 500 mg/24 h was observed only among patients with albumin-predominant proteinuria (64%; p = 0.002) and these patients had the lowest eGFR means post-ITx (no proteinuria: 84.2 +/- 16.4 vs. nonalbumin: 69.1 +/- 13.8 vs. albumin-predominant proteinuria: 65.5 +/- 16.6 ml/min/1.73 m(2), p = 0.044 for first vs. last group). In conclusion, high frequency of proteinuria was observed after ITx. However, it seems to be milder and have less impact on KF when albumin is not the major source of proteinuria. Prospective evaluation of proteinuria, including tubular function markers, should be performed to elucidate the mechanisms of kidney damage in this population.
Leitão
Cristiane B
CB
Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Froud
Tatiana
T
Cure
Pablo
P
Tharavanij
Thipaporn
T
Pileggi
Antonello
A
Ricordi
Camillo
C
Alejandro
Rodolfo
R
D000328:Adult; D000418:Albumins / Q000378:metabolism; D015984:Causality; D002478:Cells, Cultured; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D048909:Diabetes Complications / Q000503:physiopathology / Q000652:urine; D003920:Diabetes Mellitus / Q000628:therapy*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016381:Islets of Langerhans Transplantation / Q000009:adverse effects* / Q000276:immunology; D007674:Kidney Diseases / Q000139:chemically induced / Q000503:physiopathology*; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000187:drug effects / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000139:chemically induced / Q000503:physiopathology* / Q000517:prevention & control; D011507:Proteinuria / Q000139:chemically induced / Q000503:physiopathology* / Q000517:prevention & control; D012189:Retrospective Studies; D012307:Risk Factors
D000418:Albumins; D007166:Immunosuppressive Agents; D003404:Creatinine