title: Brain trace element concentration of rats treated with the plant alkaloid, vincamine.
abstract: Trace elements are essential for normal brain functions. Tiny amounts of these elements help in the formation of neurotransmitters and involved in the antioxidant defense and intracellular redox regulation and modulation of neural cells. Vincamine is a plant alkaloid used clinically as a peripheral vasodilator that increases cerebral blood flow and oxygen and glucose utilization by neural tissue to combat the effect of aging. Neurodegenerative diseases associated with aging characterized by a disturbance in trace element levels in the brain. The objective of this study was to determine the level of zinc (Zn), copper (Cu), iron (Fe), Selenium (Se), and chromium (Cr) in the brain of rats treated with vincamine. Vincamine was injected i.m. to rats at a dose of 15 mg/Kg bodyweight daily for 14 days. Twenty-four hours after the last injection, rats were killed, and brains were ashed and digested by concentrated acids and analyzed for trace elements concentrations by flame emission atomic absorption spectrophotometer. The results showed that Zn was the highest trace element in the brain of control rats (3.134 +/- 0.072 ppm) and Cr was the lowest (0.386 +/- 0.027 ppm). Vincamine administration significantly (p < 0.01) reduced the brain Fe concentration (1.393 +/- 0.165 ppm) compared to control (2.807 +/- 0.165 ppm). It was concluded that Zn was the highest trace element in the brain of rats. Vincamine administration resulted in approximately 50% reduction in brain Fe concentration which suggests its beneficial effect to prevent the oxidative stress of Fe in neurodegenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases.
authors.affiliation: Department of Physiology, Faculty of Veterinary Medicine, Alexandria University, Edfina, Egypt. hasseb2010@hotmail.com
authors.forename: Abdel-Hasseb A
authors.initials: AH
authors.lastname: Fayed
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002857:Chromium / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D005260:Female; D007501:Iron / Q000378:metabolism; D015394:Molecular Structure; D051381:Rats; D012643:Selenium / Q000378:metabolism; D013054:Spectrophotometry, Atomic; D014131:Trace Elements / Q000378:metabolism*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D014749:Vincamine / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D015032:Zinc / Q000378:metabolism
chemical_list: D014131:Trace Elements; D014665:Vasodilator Agents; D002857:Chromium; D003300:Copper; D014749:Vincamine; D007501:Iron; D012643:Selenium; D015032:Zinc