Evaluation of CNS activities of ethanol extract of roots and rhizomes of Cyperus rotundus in mice.
The ethanol extract of Cyperus rotundus (EECR) was tested for possible pharmacological effects on experimental animals. EECR significantly potentiated the sleeping time of mice induced by standard hypnotics, viz. pentobarbitone sodium, diazepam, and meprobamate in a dose dependent manner. EECR showed significant analgesic properties as evidenced by the significant reduction in the number of writhes and stretches induced in mice by 1.2% acetic acid solution. It also potentiated analgesia induced by morphine and pethidine in mice. Pretreatment with EECR caused significant protection against strychnine and leptazol-induced convulsions. The behavioral studies on mice indicate CNS depressant activity of the ethanol extract of C. rotundus.
Pal
Dilipkumar
D
Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj - 757 086, Orissa, India. drdilip2003@yahoo.co.in
Dutta
Santanu
S
Sarkar
Abhijit
A
D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000494:pharmacology*; D029786:Cyperus / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018517:Plant Roots; D027343:Rhizome; D012640:Seizures / Q000517:prevention & control
D000700:Analgesics; D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D006993:Hypnotics and Sedatives; D010936:Plant Extracts