title: Role of melanin in the pathogenesis of cutaneous sporotrichosis.
abstract: In this study, we evaluate the clinical, histopathological and ultra structural aspects of the infection by field strain (MEL(+)) and mutated strain (MEL(-)) of Sporothrix schenckii. The development of sporotrichosis at the inoculation sites was similar for both groups of animals after the second week of the experimental period. Statistical differences appeared only at weeks 3 and 5. The pigmented isolate had greater tissue invasive capacity, promoting the formation of multifocal granulomas, whereas the albino isolate induced an enhanced inflammatory response, restraining the agent to the core of the granulomas.
authors.affiliation: Departamento de Veterinária Preventiva, Faculdade de Veterinária, Universidade Federal de Pelotas, Campus Universitário s/n, 96010-900, Pelotas, Rio Grande do Sul, Brazil. imadrid_rs@yahoo.com.br
authors.forename: Isabel Martins
authors.initials: IM
authors.lastname: Madrid
authors.forename: Melissa O
authors.initials: MO
authors.lastname: Xavier
authors.forename: Antonella S
authors.initials: AS
authors.lastname: Mattei
authors.forename: Cristina G
authors.initials: CG
authors.lastname: Fernandes
authors.forename: Thomaz N
authors.initials: TN
authors.lastname: Guim
authors.forename: Rosema
authors.initials: R
authors.lastname: Santin
authors.forename: Luiz Filipe D
authors.initials: LF
authors.lastname: Schuch
authors.forename: Márcia de Oliveira
authors.initials: Mde O
authors.lastname: Nobre
authors.forename: Mário Carlos
authors.initials: MC
authors.lastname: Araújo Meireles
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005528:Foot / Q000382:microbiology / Q000473:pathology; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008297:Male; D008543:Melanins / Q000235:genetics / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000382:microbiology / Q000473:pathology; D013154:Spleen / Q000382:microbiology / Q000473:pathology; D013175:Sporothrix / Q000302:isolation & purification / Q000378:metabolism / Q000472:pathogenicity*; D013174:Sporotrichosis / Q000382:microbiology* / Q000473:pathology; D037521:Virulence Factors / Q000502:physiology*
chemical_list: D008543:Melanins; D037521:Virulence Factors