title: Development of a gene transfer-based treatment for radiation-induced salivary hypofunction.
abstract: A significant long-term side effect of radiation therapy for head and neck cancers is xerostomia, a dry mouth, due to salivary gland damage. Despite continuing efforts to eliminate this problem, many patients continue to suffer. This brief review describes our efforts to develop a gene transfer approach, employing the aquaporin-1 cDNA, to treat patients with existing radiation-induced salivary hypofunction. A Phase I/II clinical trial, using a recombinant adenoviral vector to mediate gene transfer, is currently underway.
authors.affiliation: National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA. bbaum@dir.nidcr.nih.gov
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Baum
authors.forename: Changyu
authors.initials: C
authors.lastname: Zheng
authors.forename: Ilias
authors.initials: I
authors.lastname: Alevizos
authors.forename: Ana P
authors.initials: AP
authors.lastname: Cotrim
authors.forename: Shuying
authors.initials: S
authors.lastname: Liu
authors.forename: Linda
authors.initials: L
authors.lastname: McCullagh
authors.forename: Corinne M
authors.initials: CM
authors.lastname: Goldsmith
authors.forename: Nancy
authors.initials: N
authors.lastname: McDermott
authors.forename: John A
authors.initials: JA
authors.lastname: Chiorini
authors.forename: Nikolay P
authors.initials: NP
authors.lastname: Nikolov
authors.forename: Gabor G
authors.initials: GG
authors.lastname: Illei
mesh_terms: D051398:Aquaporin 1 / Q000235:genetics / Q000627:therapeutic use*; D005260:Female; D018014:Gene Transfer Techniques; D006801:Humans; D008297:Male; D011832:Radiation Injuries / Q000235:genetics / Q000628:therapy*; D014987:Xerostomia / Q000209:etiology / Q000235:genetics / Q000628:therapy*
chemical_list: D051398:Aquaporin 1