title: Asymmetric direct aldol reactions of acetoacetals catalyzed by a simple chiral primary amine.
abstract: An asymmetric direct aldol reaction of acetoacetals is described. Under the catalysis of a simple chiral primary amine, the direct aldol reactions of acetoacetals occur exclusively on the gamma-position to give vinylogous-type aldol products with high diastereo- and enantioselectivity.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China. luosz@iccas.ac.cn
authors.forename: Sanzhong
authors.initials: S
authors.lastname: Luo
authors.forename: Yupu
authors.initials: Y
authors.lastname: Qiao
authors.forename: Long
authors.initials: L
authors.lastname: Zhang
authors.forename: Jiuyuan
authors.initials: J
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Jin-Pei
authors.initials: JP
authors.lastname: Cheng
mesh_terms: D000080:Acetals / Q000737:chemistry*; D000085:Acetates / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D007659:Ketones / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000737:chemistry
chemical_list: D000080:Acetals; D000085:Acetates; D000447:Aldehydes; D000588:Amines; D001688:Biological Products; D007659:Ketones; D018942:Macrolides; D012997:Solvents; D014753:Vinyl Compounds; C116609:3-hydroxybutanal