title: Repair of furcal perforation using a new endodontic cement.
abstract: The aim of this study was to compare the histologic response elicited by repairing furcal perforations with mineral trioxide aggregate (MTA) and a new endodontic material in the name of "calcium enriched mixture (CEM) cement" in dogs' teeth. Thirty-four premolars were randomly divided into four groups: MTA (n = 15), CEM (n = 15), positive, and negative controls (n = 4). Root canal therapy were carried out; perforations were made, and the furcation areas were then repaired with MTA or CEM cement. The animals were sacrificed after 3 months. The teeth and their adjacent structures were processed and stained with hematoxylin and eosin stain for histological evaluation. Chi-square test was used to evaluate hard tissue formation, and Mann-Whitney U test was used for the histological evaluation of inflammation. Specimens in positive controls showed severe inflammatory infiltration, prominent granulation tissue, and epithelial proliferation; negative controls demonstrated normal periodontal ligament without inflammatory reactions. Hard tissue formation was observed in all the specimens of the two experimental groups. In inflammatory evaluation, mild inflammation was detected in the experimental groups, and no statistically significant differences were observed between them. MTA and CEM cement showed similar favorable biological response in furcation perforation repair, especially in inducing the formation of cementum-like hard tissue.
authors.affiliation: Dental School, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Samiee
authors.forename: Mohammad Jafar
authors.initials: MJ
authors.lastname: Eghbal
authors.forename: Masoud
authors.initials: M
authors.lastname: Parirokh
authors.forename: Fatemeh Mashhadi
authors.initials: FM
authors.lastname: Abbas
authors.forename: Saeed
authors.initials: S
authors.lastname: Asgary
mesh_terms: D017607:Aluminum Compounds / Q000627:therapeutic use; D000818:Animals; D001641:Bicuspid; D017610:Calcium Compounds / Q000627:therapeutic use*; D025021:Cementogenesis / Q000187:drug effects; D003786:Dental Pulp Cavity / Q000293:injuries* / Q000473:pathology; D004285:Dogs; D004338:Drug Combinations; D004848:Epithelium / Q000473:pathology; D006097:Granulation Tissue / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008297:Male; D010087:Oxides / Q000627:therapeutic use; D010513:Periodontal Ligament / Q000473:pathology; D010518:Periodontitis / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology; D011897:Random Allocation; D012387:Root Canal Filling Materials / Q000627:therapeutic use*; D017640:Silicates / Q000627:therapeutic use; D013997:Time Factors; D014092:Tooth Root / Q000293:injuries* / Q000473:pathology
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate