Multiple tiny granulomatous lesions with eosinophils in a patient with smoldering-type adult T-cell leukaemia: the possibility of a new type of bronchioloalveolopathy.
We herein describe the first case, to our knowledge, of pulmonary lesions characterized by necrotizing granuloma formation with eosinophils, in a patient with smoldering-type adult T-cell leukaemia. A 74-year-old man, diagnosed with smoldering-type adult T-cell leukaemia 1 year previously, was admitted due to repeated pyrexia and concurrent identification of diffuse small pulmonary nodules. A surgical lung biopsy specimen revealed inflammatory nodular lesions measuring up to 3 mm in size, which contained necrotizing and non-necrotizing granulomas, intraluminar organization and eosinophils, and were of unknown aetiology. The patient's condition, including the radiological findings, improved gradually without any treatment. This case suggests the possibility of a new type of human T-lymphotropic virus type-1 associated bronchioloalveolar disorder.
Ishii
Hiroshi
H
Department of Respiratory Medicine, Oita University Hospital, Oita 879-5593, Japan. hishii@med.oita-u.ac.jp
Kawabata
Yoshinori
Y
Amemiya
Yuka
Y
Ogata
Masao
M
Kadota
Jun-Ichi
J
D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000473:pathology*; D055745:Bronchioles / Q000473:pathology*; D004804:Eosinophils / Q000473:pathology*; D015769:Granuloma, Respiratory Tract / Q000473:pathology*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D011650:Pulmonary Alveoli / Q000473:pathology*