SERS detection and boron delivery to cancer cells using carborane labelled nanoparticles.
Water-soluble carborane functionalized nanoparticles also co-functionalized with targeting antibodies have been prepared. We demonstrate tumour cell targeting with anti-EGFR antibodies and delivery of a high concentration of boron using SERS imaging. This suggests these materials have a therapeutic potential in addition to multimodal imaging capabilities.
Kennedy
David C
DC
Steacie Institute for Molecular Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, Canada K1A 0R6.
Duguay
Dominique R
DR
Tay
Li-Lin
LL
Richeson
Darrin S
DS
Pezacki
John P
JP
D000912:Antibodies, Neoplasm / Q000627:therapeutic use*; D001895:Boron / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems / Q000379:methods*; D066246:ErbB Receptors / Q000276:immunology*; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D013059:Spectrum Analysis, Raman
D000912:Antibodies, Neoplasm; D066246:ErbB Receptors; D001895:Boron