title: Coronally advanced flap in combination with acellular dermal matrix with or without enamel matrix derivatives for root coverage.
abstract: BACKGROUND
  Coverage of gingival recession defects has been considered as a subject of interest for dental practitioners.
  
  
  OBJECTIVE
  The present study was aimed to compare the clinical outcomes of root coverage (RC) procedures, using coronally advanced flap (CAF) in combination with acellular dermal matrix (ADM) with or without enamel matrix derivatives (EMD).
  
  
  METHODS
  A total of 36 Miller class I or II recession defects in 15 eligible patients were selected. The defects were randomly allocated to test (CAF+ADM+EMD) and control (CAF+ADM) groups. Recession depth (RD), recession width (RW), width of keratinized tissue (WKT), clinical attachment level (CAL), and the position of mucogingival junction (MGJ) were measured at baseline, two and six months after treatment.
  
  
  METHODS
  Data were analyzed using repeated measures ANOVA and paired sample t-test with the patients as statistical unit.
  
  
  RESULTS
  At two-month follow-up, the mean RC for CAF+ADM+EMD and CAF+ADM was 82.75 +/- 22 and 88.89 +/- 22 percent, respectively. However, these values did not change significantly after six months. Both treatments led to significant RC (P < 0.001), whereas no significant differences were observed in WKT, CAL, and MGJ between the study groups.
  
  
  CONCLUSIONS
  The application of EMD does not improve the clinical efficacy of ADM in combination with CAF in RC procedures.
authors.affiliation: Department of Periodontology, School of Dentistry/Drug Applied Research Center, Tabriz University of Medical Sciences, Golgasht St, Daneshgah St, Tabriz, Iran. rpourabbas@yahoo.com
authors.forename: Reza
authors.initials: R
authors.lastname: Pourabbas
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: Chitsazi
authors.forename: Emad
authors.initials: E
authors.lastname: Kosarieh
authors.forename: Pooya
authors.initials: P
authors.lastname: Olyaee
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001672:Biocompatible Materials / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use*; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000601:surgery*; D005893:Gingivoplasty / Q000379:methods*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D016555:Matched-Pair Analysis; D008875:Middle Aged; D010512:Periodontal Index; D017768:Skin, Artificial; D018709:Statistics, Nonparametric; D013524:Surgical Flaps; D016896:Treatment Outcome; D014727:Vestibuloplasty / Q000379:methods; D055815:Young Adult
chemical_list: C440568:Alloderm; D001672:Biocompatible Materials; D003746:Dental Enamel Proteins; C109069:enamel matrix proteins; D003094:Collagen