title: Mechanisms of granulocytopoiesis-stimulating activity of immobilized granulocytic colony-stimulating factor in cytostatic myelosuppression.
abstract: The hemostimulatory effects of granulocytic CSF, immobilized on polyethyleneglycol using radiation synthesis nanotechnology, were studied on the model of cyclophosphamide-induced myelosuppression. Immobilization of granulocytic CSF led to stimulation of granulomonocytopoiesis by increasing functional activity of granulomonocytic precursors and secretion of humoral factors by elements of hemopoiesis-inducing microenvironment, and due to more intensive formation of hemopoietic islets. The granulocytopoiesis-stimulating effect of immobilized granulocytic CSF was comparable to the effect of standard nonconjugated granulocytic CSF. Specific activity of immobilized granulocytic CSF in oral treatment was demonstrated.
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: E I
authors.initials: EI
authors.lastname: Vereshchagin
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: N N
authors.initials: NN
authors.lastname: Ermakova
authors.forename: P G
authors.initials: PG
authors.lastname: Madonov
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: M Yu
authors.initials: MY
authors.lastname: Minakova
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: T V
authors.initials: TV
authors.lastname: Firsova
authors.forename: T Yu
authors.initials: TY
authors.lastname: Khrichkova
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects*; D003520:Cyclophosphamide / Q000633:toxicity*; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006098:Granulocytes / Q000166:cytology*; D006410:Hematopoiesis / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011994:Recombinant Proteins
chemical_list: D000970:Antineoplastic Agents; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D003520:Cyclophosphamide