title: Introduction to the Japan Mouse Clinic at the RIKEN BioResource Center.
abstract: A systematic and comprehensive phenotyping platform has been developed by the RIKEN ENU-mutagenesis project between 1999 and 2007. As a result of phenotype screening on this platform, we have discovered about 400 mutants as animal models for human diseases. All information regarding these mouse mutants is now available to the public through our home page (http://www.brc.riken.jp/lab/gsc/mouse/indexJ.html). In 2008, we reconstructed the existing phenotyping platform and built a new platform. The new system has a hierarchical structure, consisting of a fundamental pipeline that utilizes the existing platform and an additional pipeline, which is optimized for more in-depth phenotyping assays. Using this system, we have started to perform more comprehensive phenotyping of mouse mutants. We have opened this system to Japanese scientists as the Japanese Mouse Clinic. It is anticipated that existing mouse mutants will be reevaluated as disease models by identifying novel phenotypes on the new platform. We will share detailed information about the standard operating procedures (SOPs) of our phenotyping analyses with other related large-scale projects, such as the European Mouse Disease Clinic (EUMODIC) and the German Mouse Clinic (GMC). Moreover, we will contribute to international efforts to standardize mouse phenotype data by sharing annotation of mutant phenotypes, which are made by internationally standardized methods, with other related projects.
authors.affiliation: Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Center, Tsukuba City, Ibaraki, Japan.
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Wakana
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Tamio
authors.initials: T
authors.lastname: Furuse
authors.forename: Kimio
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Ikuo
authors.initials: I
authors.lastname: Miura
authors.forename: Hideki
authors.initials: H
authors.lastname: Kaneda
authors.forename: Ikuko
authors.initials: I
authors.lastname: Yamada
authors.forename: Hiromi
authors.initials: H
authors.lastname: Motegi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Toki
authors.forename: Maki
authors.initials: M
authors.lastname: Inoue
authors.forename: Osamu
authors.initials: O
authors.lastname: Minowa
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Noda
authors.forename: Kazunori
authors.initials: K
authors.lastname: Waki
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Masuya
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Obata
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D016208:Databases, Factual; D004195:Disease Models, Animal; D005260:Female; D016678:Genome; D006801:Humans; D007253:Information Centers / Q000458:organization & administration*; D007391:International Cooperation; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains / Q000235:genetics*; D010641:Phenotype; D012015:Reference Standards