Pathogenic role of anti-endothelial cell antibodies in autoimmune rheumatic diseases.
Anti-endothelial cells antibodies have been detected in numerous autoimmune and inflammatory diseases, including systemic lupus erythematous, rheumatoid arthritis, vasculitis and sarcoidosis. Anti-endothelial cells antibodies bind to endothelial cell antigens and induce endothelial damage. Their effects on the endothelial cell have been considered responsible, at least in part, by the vascular injury which occurs in these pathological conditions.
Domiciano
D S
DS
Rheumatology Division, São Paulo University School of Medicine, São Paulo, Brazil.
Carvalho
J F
JF
Shoenfeld
Y
Y
D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology; D042783:Endothelial Cells / Q000166:cytology / Q000276:immunology / Q000473:pathology; D004730:Endothelium, Vascular / Q000166:cytology / Q000276:immunology / Q000473:pathology; D006801:Humans; D012216:Rheumatic Diseases / Q000276:immunology / Q000473:pathology
D001323:Autoantibodies; C087589:anti-endothelial cell antibody