title: Respiratory syncytial virus vaccine development.
abstract: Respiratory syncytial virus (RSV) is a clinically significant cause of respiratory tract disease, especially among high-risk infants and immunocompromised and elderly adults. Despite the burden of disease, there is no licensed prophylactic RSV vaccine. The initial efforts to develop an RSV vaccine involved formalin-inactivated virus preparations that unexpectedly caused vaccine-enhanced disease in clinical trials in RSV-naive children. Over the last 40 years, cautious and deliberate progress has been made toward RSV vaccine development using various experimental approaches, including live attenuated strains and vector-based and viral protein subunit/DNA-based candidates. The scientific rationale, preclinical testing, and clinical development of each of these approaches are reviewed.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. Yoshihiko_Murata@urmc.rochester.edu
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Murata
mesh_terms: D006801:Humans; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D022261:Respiratory Syncytial Virus Vaccines / Q000737:chemistry; D018113:Respiratory Syncytial Virus, Human / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D022261:Respiratory Syncytial Virus Vaccines