Hepato-biliary late effects in survivors of childhood and adolescent cancer: a report from the Children's Oncology Group.
Curative therapy for childhood and adolescent cancer translates to 1 in 640 young adults being a survivor of cancer. Although acute hepato-biliary toxicity occurs commonly during pediatric cancer therapy, the impact of antineoplastic therapy on long-term liver health in childhood/adolescent cancer survivors is unknown. This article reviews the medical literature on late liver dysfunction following treatment for childhood/adolescent cancer. We also outline the Children's Oncology Group (COG) guidelines for screening and follow-up of hepato-biliary sequelae. As the population of survivors grow and age, vigilance for risks to hepatic health needs to continue based on specific exposures during curative cancer therapy.
Castellino
Sharon
S
Department of Pediatrics, Wake Forest University, Winston-Salem, NC27157, USA. scastell@wfubmc.edu
Muir
Andrew
A
Shah
Ami
A
Shope
Sheila
S
McMullen
Kevin
K
Ruble
Kathy
K
Barber
Ashley
A
Davidoff
Andrew
A
Hudson
Melissa M
MM
D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects; D001649:Bile Duct Diseases / Q000209:etiology / Q000517:prevention & control*; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000209:etiology / Q000517:prevention & control; D002648:Child; D003266:Continuity of Patient Care; D006525:Hepatitis, Viral, Human / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008107:Liver Diseases / Q000209:etiology / Q000517:prevention & control*; D008403:Mass Screening / Q000379:methods; D009369:Neoplasms / Q000150:complications / Q000628:therapy*; D017410:Practice Guidelines as Topic; D011878:Radiotherapy / Q000009:adverse effects; D033581:Stem Cell Transplantation / Q000009:adverse effects; D017741:Survivors; D065227:Transfusion Reaction
D000970:Antineoplastic Agents