Two-year body composition analyses of long-lived GHR null mice.
Growth hormone receptor gene-disrupted (GHR-/-) mice exhibit increased life span and adipose tissue mass. Although this obese phenotype has been reported extensively for young adult male GHR-/- mice, data for females and for other ages in either gender are lacking. Thus, the purpose of this study was to evaluate body composition longitudinally in both male and female GHR-/- mice. Results show that GHR-/- mice have a greater percent fat mass with no significant difference in absolute fat mass throughout life. Lean mass shows an opposite trend with percent lean mass not significantly different between genotypes but absolute mass reduced in GHR-/- mice. Differences in body composition are more pronounced in male than in female mice, and both genders of GHR-/- mice show specific enlargement of the subcutaneous adipose depot. Along with previously published data, these results suggest a consistent and intriguing protective effect of excess fat mass in the subcutaneous region.
Berryman
Darlene E
DE
School of Human and Consumer Sciences, College of Health and Human Services, Ohio University, Athens, OH 45701, USA. berrymad@ohio.edu
List
Edward O
EO
Palmer
Amanda J
AJ
Chung
Min-Yu
MY
Wright-Piekarski
Jacob
J
Lubbers
Ellen
E
O'Connor
Patrick
P
Okada
Shigeru
S
Kopchick
John J
JJ
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001823:Body Composition / Q000502:physiology*; D004195:Disease Models, Animal; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D008136:Longevity / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000235:genetics / Q000378:metabolism*; D011986:Receptors, Somatotropin / Q000235:genetics* / Q000378:metabolism
D011986:Receptors, Somatotropin