Larvicidal activity of extracts from three Plumbago spp against Anopheles gambiae.
Three Plumbago spp have been tested for mosquito larvicidal activity. The crude extracts exhibiting the highest larvicidal activity against Anopheles gambiae were hexane (LC50 = 6.4 microg/mL) and chloroform (LC50 = 6.7 microg/mL) extracts from Plumbago zeylanica Linn, chloroform (LC50 = 6.7 ug/mL) extract from Plumbago stenophylla Bull and ethyl acetate (LC50 = 4.1 microg/mL) extract from Plumbago dawei Rolfe. These LC50 values were within 95% confidence limits. 5-hydroxy-2-methyl-1,4-naphthoquinone (plumbagin) 1 (LC50 = 1.9 microg/mL) and beta-sitosterol 2 were characterised from ethyl acetate extract of root bark of P. dawei, a native medicinal plant growing in Kenya, based on spectral analysis and comparisons with data in literature.
Maniafu
Barasa M
BM
Chemistry Department, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.
Wilber
Lwande
L
Ndiege
Isaiah O
IO
Wanjala
Cornelius C
CC
Akenga
Teresa Ayuko
TA
D000818:Animals; D000852:Anopheles; D007306:Insecticides; D007814:Larva / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D029606:Plumbaginaceae / Q000737:chemistry* / Q000145:classification
D007306:Insecticides; D010936:Plant Extracts