[Prostaglandin E(2) and omeprazole in treating poisoning related acute mucosal lesion].
OBJECTIVE
To determine the effects of prostaglandin E(2) alone and the combination with omeprazole for poisoning related acute mucosal lesion.


METHODS
Forty-two healthy SD rats were randomly divided into 7 groups: control group (control) , methamidophos poisoning model group (intox), 10 mg/kg omeprazole group (ome1), 50 mg/kg omeprazole group (ome2), 10 microg/kg prostaglandin E(2) group (PG1), 50 microg/kg prostaglandin E(2) group (PG2), 10 microg/kg prostaglandin E(2) combined with 10 mg/kg omeprazole group (union). The gastric ulcer index was counted and the content of serum cholinesterase, endothelin, and tumor necrosis factor were measured, and dependability was analyzed.


RESULTS
There was no obvious difference between the prostaglandin group and the poisoning model group in gastric ulcer index, endothelin, and tumor necrosis factor. The omeprazole alone and the combination treatment could improve the acute gastric mucosa lesion induced by methamidophos poisoning.


CONCLUSIONS
Prostaglandin E(2) alone can not obviously improve the acute gastric mucosa lesion by methamidophos poisoning. The combination with omeprazole may be a promising treatment.
Fan
Xiao
X
Department of Emergency, Second Xiangya Hospital, Central South Universily, Changsha, China.
Xu
Yang
Y
Zhang
Hongliang
H
D000208:Acute Disease; D000818:Animals; D015232:Dinoprostone / Q000008:administration & dosage*; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage*; D062025:Organophosphate Poisoning; D011041:Poisoning / Q000150:complications / Q000188:drug therapy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013272:Stomach Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology
D004791:Enzyme Inhibitors; D015232:Dinoprostone; D009853:Omeprazole