title: Polymorphism in heme oxygenase-1 (HO-1) promoter and alcohol are related to the risk of esophageal squamous cell carcinoma on Chinese males.
abstract: Chronic alcohol drinking is astrong risk factor for esophageal squamous cell carcinoma (ESCC). In this study, the correlation between the HO-1 gene promoter polymorphism and alcohol, along with the risk of ESCC on Chinese males, was analyzed.The case-control study was performed in 143 ESCC patients and 264 cancer-free controls. All subjects were males. Allelotypic frequencies of (GT)n repeat were examed by PCR-based genotyping and DNA sequencing. The frequencies of L-allele and L-allele carriers (S/L and L/L genotypes) was significantly higher in ESCC patients than in controls (p =0.001 and 0.004), The adjusted ORs for ESCC with S/L and L/L genotypes vs S/S genotype was 2.212 (95% CI 1.297-3.775, p= 0.004). The adjusted ORs for light, moderate and heavy drinking was 1.467, 5.215 and 9.525 respectively among L-allele carriers (S/L and L/L genotypes )and 1.389, 2.096 and 3.039 respectively for the S/S genotype. Length of a(GT)n repeat in the HO-1 gene promoter may be associated with the development of ESCC in Chinese male drinkers. Reducing alcohol intake might be most protective among L-allele carriers of this polymorphism.
  
  
  BACKGROUND
  esophageal squamous cell carcinoma; heme oxygenase-1 promoter polymorphism; alcohol drinking.
authors.affiliation: Cancer Centre, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. gangwuh@yahoo.com.cn
authors.forename: J L
authors.initials: JL
authors.lastname: Hu
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Li
authors.forename: W
authors.initials: W
authors.lastname: Liu
authors.forename: R G
authors.initials: RG
authors.lastname: Zhang
authors.forename: G L
authors.initials: GL
authors.lastname: Li
authors.forename: T
authors.initials: T
authors.lastname: Wang
authors.forename: J H
authors.initials: JH
authors.lastname: Ren
authors.forename: G
authors.initials: G
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D044466:Asian People / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000235:genetics; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000209:etiology* / Q000235:genetics; D005838:Genotype; D051547:Heme Oxygenase-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012307:Risk Factors
chemical_list: D051547:Heme Oxygenase-1