Haplotype of IL-8 -251T and 781C is associated with the susceptibility to respiratory syncytial virus.
OBJECTIVE
To study the association of haplotypes of IL-8 -251T/A and 781 C/T single nucleotide polymorphisms (SNPs) with the susceptibility of respiratory syncytial virus (RSV).


METHODS
This study included 101 hospitalized patients under 2 years who suffered from RSV pneumonia and 108 hospitalized patients under 2 years who suffered only from pneumonia without RSV infection. Genotypes of two SNP loci in all enrolled persons were defined by allele-specific polymerase chain reaction. The allele's frequencies of SNPs were analyzed with case-control study, linkage of two loci and haplotypes composed by the two loci were also studied.


RESULTS
(i) The frequency of IL-8 -251T in cases was dramatically high (OR = 2.08, p = 0.0002). (ii) Haplotype of TC was significantly high in cases (p = 0.01).


CONCLUSIONS
These findings support that haplotype of TC composed by IL-8 -251T and 781C is associated with the susceptibility of RSV.
Lu
Aizhen
A
Department of Respiratory Care, Children's Hospital of Fudan University, Shanghai 201102, China.
Wang
Libo
L
Zhang
Xiaobo
X
D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007223:Infant; D016209:Interleukin-8 / Q000235:genetics*; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D020641:Polymorphism, Single Nucleotide; D018357:Respiratory Syncytial Virus Infections / Q000235:genetics*; D012136:Respiratory Syncytial Viruses / Q000235:genetics / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA
C508606:CXCL8 protein, human; D016209:Interleukin-8