Survey on warfarin pharmacogenetic testing among anticoagulation providers.
OBJECTIVE
Our study aimed to assess anticoagulation providers' perception and knowledge of warfarin pharmacogenetic testing, and to identify barriers to using it in their clinical practice.


METHODS
An online survey that included 5 perception and 5 knowledge questions about the testing was conducted on anticoagulation providers in North America. Participants were also asked to rank the three most significant barriers to using it.


RESULTS
The survey response rate was 22%. Over 40% of 448 providers participating in the study were undecided about the testing's potential clinical benefits. On average, providers correctly answered 2 out of 5 knowledge questions. Self confidence in interpreting test results significantly predicted the providers' accuracy of the interpretation. The top three barriers were inadequate literature evidence, testing's impracticality and unproven applicability.


CONCLUSIONS
Most of the providers did not respond to the survey. Our study suggests inadequate literature evidence influences providers' perception and their use of the testing. In addition, provider education on warfarin pharmacogenetics may be necessary for testing's widespread use.
Kadafour
Maha
M
Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA 94143-0622, USA.
Haugh
Roshanak
R
Posin
Monica
M
Kayser
Steven R
SR
Shin
Jaekyu
J
D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology*; D005260:Female; D006801:Humans; D019359:Knowledge; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics; D010818:Practice Patterns, Physicians'; D014859:Warfarin / Q000494:pharmacology*
D000925:Anticoagulants; D014859:Warfarin