PI3 kinase signals BCR-dependent mature B cell survival.
Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence that the survival of BCR deficient mature B cells can be rescued by a single signaling pathway downstream of the BCR, namely PI3K signaling, with the FOXO1 transcription factor playing a central role.
Srinivasan
Lakshmi
L
Program of Cellular and Molecular Medicine, Children's Hospital, and Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA.
Sasaki
Yoshiteru
Y
Calado
Dinis Pedro
DP
Zhang
Baochun
B
Paik
Ji Hye
JH
DePinho
Ronald A
RA
Kutok
Jeffrey L
JL
Kearney
John F
JF
Otipoby
Kevin L
KL
Rajewsky
Klaus
K
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000378:metabolism*; D002470:Cell Survival; D051379:Mice; D018345:Mice, Knockout; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*; D015398:Signal Transduction
D011947:Receptors, Antigen, B-Cell; D019869:Phosphatidylinositol 3-Kinases