[Cytological criteria for human hepatic cirrhosis-cancer and hepatic cirrhosis].
Trepan biopsy specimens were studied in 12 patients with hepatic cirrhosis-cancer and in 22 patients with hepatic cirrhosis. Blood antibodies to hepatitis C virus (HCV) or HBsAg were detected in 50% of the patients with hepatic cirrhosis-cancer and in 18.1% of those with hepatic cirrhosis. Polymerase chain reaction detection of HCV DNA in the cells of trepan biopsy specimens suggests its role in the pathogenesis of hepatic cirrhosis and hepatic cirrhosis-cancer. The cytological criteria for hepatic cirrhosis-cancer, unlike hepatic cirrhosis, are that the cytological specimen shows a preponderance of atypical hepatocytes with hyperchromic angular nuclei occupying the bulk of a cell, as well as mitoses in them.
Ershov
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Biazovaia
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Narvskaia
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D000368:Aged; D002467:Cell Nucleus / Q000378:metabolism / Q000473:pathology / Q000821:virology; D004279:DNA, Viral / Q000097:blood; D005260:Female; D016174:Hepacivirus / Q000378:metabolism; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000378:metabolism; D018937:Hepatitis C Antibodies / Q000097:blood; D022781:Hepatocytes / Q000378:metabolism / Q000473:pathology / Q000821:virology; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000473:pathology* / Q000821:virology; D008113:Liver Neoplasms / Q000097:blood* / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies