title: Progesterone sperm chemoattraction may be modulated by its corticosteroid-binding globulin carrier protein.
abstract: Progesterone, the main steroidal component secreted by the cumulus cells that surround the egg, chemotactically guides human spermatozoa. The aim of this work was to evaluate whether the carrier protein corticosteroid-binding globulin also participates in the sperm P chemotactic response. By means of videomicroscopy and image analysis, we observed that corticosteroid-binding globulin modulates the chemotactic activity of P, when a solution of corticosteroid-binding globulin + P is at the nanomolar range.
authors.affiliation: Centro de Biología Celular y Molecular, Universidad Nacional de Córdoba, X5016GCA Córdoba, Argentina.
authors.forename: Maria Eugenia
authors.initials: ME
authors.lastname: Teves
authors.forename: Hector Alejandro
authors.initials: HA
authors.lastname: Guidobaldi
authors.forename: Diego Rafael
authors.initials: DR
authors.lastname: Uñates
authors.forename: Raul
authors.initials: R
authors.lastname: Sanchez
authors.forename: Werner
authors.initials: W
authors.lastname: Miska
authors.forename: Laura Cecilia
authors.initials: LC
authors.lastname: Giojalas
mesh_terms: D002352:Carrier Proteins / Q000502:physiology; D002633:Chemotaxis / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D011374:Progesterone / Q000494:pharmacology*; D055101:Semen Analysis / Q000379:methods; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D014156:Transcortin / Q000494:pharmacology* / Q000502:physiology
chemical_list: D002352:Carrier Proteins; D011374:Progesterone; D014156:Transcortin