title: Methadone-induced toxic leukoencephalopathy: MR imaging and MR proton spectroscopy findings.
abstract: We report the clinical, MR imaging, and proton MR spectroscopy findings in a middle-aged woman with proved methadone-induced toxic leukoencephalopathy. The imaging characteristics of this unusual condition have been reported only rarely in the medical literature. We show that the imaging findings in methadone-induced toxic leukoencephalopathy are similar, though not identical, to previously reported cases of neurologic deterioration due to heroin inhalation.
authors.affiliation: Department of Radiology, Antwerp University Hospital, University of Antwerp, Edegem, Belgium. rodrigo.salgado@uza.be
authors.forename: R A
authors.initials: RA
authors.lastname: Salgado
authors.forename: P G
authors.initials: PG
authors.lastname: Jorens
authors.forename: I
authors.initials: I
authors.lastname: Baar
authors.forename: P
authors.initials: P
authors.lastname: Cras
authors.forename: G
authors.initials: G
authors.lastname: Hans
authors.forename: P M
authors.initials: PM
authors.lastname: Parizel
mesh_terms: D000368:Aged; D000701:Analgesics, Opioid / Q000009:adverse effects*; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D056784:Leukoencephalopathies / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008691:Methadone / Q000009:adverse effects*; D011522:Protons
chemical_list: D000701:Analgesics, Opioid; D011522:Protons; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline; D008691:Methadone