title: Androgen deprivation therapy and estrogen deficiency induced adverse effects in the treatment of prostate cancer.
abstract: Androgen deprivation therapy (ADT) is the standard of care for metastatic prostate cancer and is increasingly used to treat asymptomatic patients with prostate-specific antigen recurrence after failed primary therapy. Although effective, ADT is associated with multiple adverse effects, many of which are related to the estrogen deficiency that occurs as a result of treatment. These include increased fracture risk, hot flashes, gynecomastia, serum lipid changes and memory loss. By providing clinicians with a greater awareness of the estrogen deficiency induced adverse effects from ADT, they can proactively intervene on the physical and psychological impact these effects have on patients.
authors.affiliation: Department of Surgery (Urology), Durham VA Medical Center and Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA. steve.freedland@duke.edu
authors.forename: S J
authors.initials: SJ
authors.lastname: Freedland
authors.forename: J
authors.initials: J
authors.lastname: Eastham
authors.forename: N
authors.initials: N
authors.lastname: Shore
mesh_terms: D000726:Androgen Antagonists / Q000009:adverse effects*; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects; D004967:Estrogens / Q000172:deficiency*; D050723:Fractures, Bone / Q000209:etiology; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000037:antagonists & inhibitors; D006177:Gynecomastia / Q000209:etiology; D019584:Hot Flashes / Q000209:etiology; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D011788:Quality of Life; D012306:Risk; D013739:Testosterone / Q000172:deficiency
chemical_list: D000726:Androgen Antagonists; D018931:Antineoplastic Agents, Hormonal; D004967:Estrogens; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone