title: Improvement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoids.
abstract: OBJECTIVE
  To evaluate the hematological profile, oxidative stress, and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoids for 12 months.
  
  
  METHODS
  Twenty-one beta-thalassemia/Hb E patients were given 2 capsules of 250 mg each of curcuminoids (a total of 500 mg) daily for 12 months. Blood was collected every 2 months during treatment and 3 months after withdrawal and was determined for complete blood count, malonyldialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), reduced glutathione (GSH) in red blood cells (RBC), and non-transferrin bound iron (NTBI) in serum.
  
  
  RESULTS
  The increased oxidative stress in beta-thalassemia/Hb E patients was shown by higher levels of MDA, SOD, GSH-Px in RBC, serum NTBI, and lower level of RBC GSH. Curcuminoids administration resulted in improvement of all the measured parameters as long as they were administered. After 3 months withdrawal of treatment, all parameters returned close to baseline levels.
  
  
  CONCLUSIONS
  Curcuminoids may be used to ameliorate oxidative damage in patients with beta-thalassemia/Hb E disease.
authors.affiliation: Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok 10700, Thailand. sirkp@mahidol.ac.th
authors.forename: Ruchaneekorn W
authors.initials: RW
authors.lastname: Kalpravidh
authors.forename: Noppadol
authors.initials: N
authors.lastname: Siritanaratkul
authors.forename: Praphaipit
authors.initials: P
authors.lastname: Insain
authors.forename: Ratiya
authors.initials: R
authors.lastname: Charoensakdi
authors.forename: Narumol
authors.initials: N
authors.lastname: Panichkul
authors.forename: Suneerat
authors.initials: S
authors.lastname: Hatairaktham
authors.forename: Somdet
authors.initials: S
authors.lastname: Srichairatanakool
authors.forename: Chada
authors.initials: C
authors.lastname: Phisalaphong
authors.forename: Eliezer
authors.initials: E
authors.lastname: Rachmilewitz
authors.forename: Suthat
authors.initials: S
authors.lastname: Fucharoen
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D003474:Curcumin / Q000494:pharmacology* / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006446:Hemoglobin E / Q000378:metabolism*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000097:blood; D055815:Young Adult; D017086:beta-Thalassemia / Q000097:blood / Q000188:drug therapy*
chemical_list: D000975:Antioxidants; D004791:Enzyme Inhibitors; D008315:Malondialdehyde; D006446:Hemoglobin E; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D003474:Curcumin