title: Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study.
abstract: Nutritional and immunological status of patients with obstructive jaundice is usually severely altered, with high mortality rates. The n-3 polyunsaturate fatty acids (PUFA), particularly eicosapentaenoic acid (EPA, 20:5 n-3), posess potent immunomodulatory activities. Thus, our aim was to compare the plasma phospholipid fatty acid (FA) composition of these patients with healthy subjects, as well as before and after 7 days preoperative supplementation with high doses of EPA (0.9 g per day) and docosahexaenoic acid (DHA, 22:6 n-3, 0.6 g per day). We found impaired FA status in obstructive jaundice patients, especially EPA, DHA and PUFA, but significantly increased content of total n-3 FA, 22:5 n-3 FA and particularly EPA, which increased more than 3 fold, after 7 days supplementation. In addition, the n6/n3 ratio significantly decreased from 14.24 to 10.24, demonstrating severely improved plasma phospholipid profile in these patients after the intervention.
authors.affiliation: Institute for Medical Research, Department for Nutrition and Metabolism, University of Belgrade, Tadeusa Koscuska 1, 11129 Belgrade, Serbia.
authors.forename: Tamara
authors.initials: T
authors.lastname: Popovic
authors.forename: Marija
authors.initials: M
authors.lastname: Ranic
authors.forename: Predrag
authors.initials: P
authors.lastname: Bulajic
authors.forename: Miroslav
authors.initials: M
authors.lastname: Milicevic
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Arsic
authors.forename: Vesna
authors.initials: V
authors.lastname: Vucic
authors.forename: Marija
authors.initials: M
authors.lastname: Glibetic