title: An interactive graphical user interface for comprehensive analysis of human and swine cardiac monophasic action potential.
abstract: This research describes a novel monophasic action potential (MAP) annotation algorithm coupled with an interactive graphical user interface (GUI). This algorithm incorporates a number of features to reduce error. Additionally, the GUI has several convenient features to view and manipulate the annotation visually. We analyzed data from swine and human hearts in normal sinus rhythm, during myocardial ischemia, and while eliciting high rates. Validation results indicate correlation >90% between human and computer measurements. This analysis system has several clinical applications in electrophysiological interventions, pharmacodynamic therapies, ischemia detection, and/or in assessment of the time course of electrical activation.
authors.affiliation: Medtronic Neuromodulation, Minneapolis, Minnesota 55432, USA. maneesh@ieee.org
authors.forename: Maneesh
authors.initials: M
authors.lastname: Shrivastav
authors.forename: Paul A
authors.initials: PA
authors.lastname: Iaizzo
mesh_terms: D000200:Action Potentials; D000368:Aged; D000465:Algorithms; D000818:Animals; D019070:Cell Lineage; D003196:Computer Graphics; D004562:Electrocardiography / Q000706:statistics & numerical data; D055724:Electrophysiological Phenomena; D006321:Heart / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008955:Models, Cardiovascular; D012815:Signal Processing, Computer-Assisted; D012984:Software; D034421:Sus scrofa; D014584:User-Computer Interface