Mitochondrial pharmacogenomics: barcode for antibiotic therapy.
Ribosomal RNA (rRNA)-targeting drugs inhibit protein synthesis and represent effective antibiotics for the treatment of infectious diseases. Given the bacterial origins of mitochondria, the molecular and structural components of the protein expression system are much alike. Moreover, the mutational rate of mitochondrial rRNAs is higher than that of nuclear rRNAs, and some of these mutations might simulate the microorganism's rRNA structure. Consequently, individuals become more susceptible to antibiotics, the mitochondrial function is affected and toxic effects appear. Systems are available to analyze the interaction between antibiotics and mitochondrial DNA genetic variants, thus making a pharmacogenomic approach to antibiotic therapy possible.
Pacheu-Grau
David
D
Departamento de Bioquímica, Biología Molecular y Celular, Centro de Investigaciones Biomédicas En Red de Enfermedades Raras, Instituto Aragonés de Ciencias de Salud, Universidad de Zaragoza, 50013 Zaragoza, Spain.
Gómez-Durán
Aurora
A
López-Pérez
Manuel J
MJ
Montoya
Julio
J
Ruiz-Pesini
Eduardo
E
D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000494:pharmacology*; D002461:Cell Line, Transformed; D004272:DNA, Mitochondrial / Q000187:drug effects*; D004275:DNA, Ribosomal / Q000187:drug effects; D014644:Genetic Variation; D006801:Humans; D008928:Mitochondria / Q000187:drug effects; D008957:Models, Genetic; D010085:Oxidative Phosphorylation; D010641:Phenotype; D014176:Protein Biosynthesis / Q000187:drug effects; D012313:RNA / Q000187:drug effects*; D000077278:RNA, Mitochondrial; D012335:RNA, Ribosomal / Q000187:drug effects
D000900:Anti-Bacterial Agents; D004272:DNA, Mitochondrial; D004275:DNA, Ribosomal; D000077278:RNA, Mitochondrial; D012335:RNA, Ribosomal; D012313:RNA