title: [Vitaherpavac is the first Russian herpes simplex virus vaccine obtained on the Vero B continuous cell line].
abstract: Vitaherpavac, a dry inactivated herpes simplex virus (HSV) culture vaccine, has been obtained, by using the Vero B continuous cell line as a substrate for accumulation of herpes simplex virus types 1 (US strain) and 2 (VN strain). Vitaherpavac and the similar vaccine Herpovax made by the Research Institute of Vaccines and Sera, Saint Petersburg (for which preparation a primary trypsinized chick embryo cell culture used as a substrate for accumulation of HSV types 1 and 2), underwent comparative clinical trials. The tolerability and therapeutic effectiveness of the vaccine were tested in patients diagnosed as having chronic frequently recurring herpes. The trials have yielded positive results that suggest that it is expedient to introduce of the new vaccine Vitaherpavac into practice to treat chronic recurrent herpetic infection of various localizations. Vitaherpavac has been registered in the Russian Federation and permitted for medical application.
authors.forename: O A
authors.initials: OA
authors.lastname: Barkhaleva
authors.forename: I P
authors.initials: IP
authors.lastname: Ladyzhenskaia
authors.forename: M S
authors.initials: MS
authors.lastname: Vorob'eva
authors.forename: N V
authors.initials: NV
authors.lastname: Shalunova
authors.forename: R Ia
authors.initials: RIa
authors.lastname: Podcherniaeva
authors.forename: G R
authors.initials: GR
authors.lastname: Mikhaĭlova
authors.forename: T V
authors.initials: TV
authors.lastname: Khorosheva
authors.forename: I F
authors.initials: IF
authors.lastname: Barinskiĭ
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002522:Chlorocebus aethiops; D002908:Chronic Disease; D006561:Herpes Simplex / Q000628:therapy*; D022301:Herpes Simplex Virus Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D018259:Herpesvirus 1, Human / Q000276:immunology*; D018258:Herpesvirus 2, Human / Q000276:immunology*; D006801:Humans; D007271:Injections, Intradermal; D008875:Middle Aged; D016896:Treatment Outcome; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D014709:Vero Cells
chemical_list: D022301:Herpes Simplex Virus Vaccines; D015164:Vaccines, Inactivated; C545581:Vitaherpavac