Respiratory viruses in bronchiolitis and their link to recurrent wheezing and asthma.
Bronchiolitis is the leading cause of hospitalization for children younger than 1 year of age and these hospitalized children have an increased risk for developing childhood asthma. It remains unclear, however, which children who have severe bronchiolitis (eg, an episode requiring hospitalization) will develop recurrent wheezing or asthma. Although many environmental and genetic factors may play a role in the pathway from bronchiolitis to asthma, this article focuses on the viruses that have been linked to bronchiolitis and how these viruses may predict or contribute to future wheezing and asthma. The article also discusses vitamin D as an emerging risk factor for respiratory infections and wheezing.
Mansbach
Jonathan M
JM
Department of Medicine, Children's Hospital Boston, Harvard Medical School, Main Clinical Building 9 South, #9157, Boston, MA 02115, USA. jonathan.mansbach@childrens.harvard.edu
Camargo
Carlos A
CA
D000293:Adolescent; D001249:Asthma / Q000453:epidemiology / Q000821:virology*; D001990:Bronchiolitis, Viral / Q000150:complications* / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D012135:Respiratory Sounds / Q000209:etiology*; D012307:Risk Factors; D014808:Vitamin D Deficiency / Q000150:complications