Catalysis of fluorine addition to double bond: an improvement of method for synthesis of (18)F PET agents.
Catalysis for reaction of electrophilic fluorine addition to a fluorinated double bond is described. The presence of small amounts of iodine, bromine, or boron trifluoride increases an overall product yield and degree of fluorine incorporation, making the reaction a more efficient method for preparation of (18)F positron emission tomography agents. A possible mechanism of catalytic action of iodine is discussed.
Kachur
Alexander V
AV
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. kachur@mail.med.upenn.edu
Dolbier
William R
WR
Xu
Wei
W
Koch
Cameron J
CJ
D002384:Catalysis; D005461:Fluorine / Q000737:chemistry*; D019788:Fluorodeoxyglucose F18 / Q000138:chemical synthesis*; D007553:Isotope Labeling / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005461:Fluorine