title: Neuropsychological status of elderly patients with diabetes mellitus.
abstract: OBJECTIVE
  Diabetes mellitus (DM) is an important risk factor for Alzheimer's disease (AD) but the relationship between DM and amnestic mild cognitive impairment (aMCI), characterized by isolated memory loss, is unclear. We studied the prevalence of MCI in DM patients.
  
  
  METHODS
  Neuropsychological status was evaluated using the Rivermead Behavioral Memory Test (RBMT) and the Mini Mental State Examination (MMSE). Subjects consisted of 103 consecutive diabetic patients hospitalized for diabetic education. Patients with severe diabetic complications or cerebrovascular accidents were excluded.
  
  
  RESULTS
  Neuropsychological evaluation of DM patients showed that 71% were normal (MMSE score > or =24 and RBMT score > or =15), 5% had amnestic MCI (aMCI) (MMSE score > or =24 and RBMT score <15) and the remaining 23% had dementia (MMSE score <24). The percentage of patients with dementia was significantly higher in the DM group than in the control group (p<0.04). RBMT score and HbA1c were mildly correlated in diabetic patients.
  
  
  CONCLUSIONS
  High blood sugar may cause deterioration in not only memory function but also other cognitive domains in elderly patients with DM. Monitoring the neuropsychological status of this patient population is important.
authors.affiliation: Department of Geriatrics and Neurology, Osaka City University Medical School, Japan. h.shimada@med.osaka-cu.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimada
authors.forename: Takami
authors.initials: T
authors.lastname: Miki
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamura
authors.forename: Suzuka
authors.initials: S
authors.lastname: Ataka
authors.forename: Masanori
authors.initials: M
authors.lastname: Emoto
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Nishizawa
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology; D001786:Blood Glucose / Q000032:analysis; D003072:Cognition Disorders / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000503:physiopathology* / Q000523:psychology*; D003927:Diet, Diabetic; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008568:Memory; D008875:Middle Aged; D009484:Neuropsychology / Q000145:classification*; D015995:Prevalence; D011581:Psychological Tests
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin