title: Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.
abstract: BACKGROUND
  We surveyed lymphomas to determine the range of expression of the mantle cell lymphoma-associated SOX11 transcription factor and its relation to cyclin D1.
  
  
  METHODS
  On hundred and seventy-two specimens were immunostained for the SOX11 N and C termini. Cyclin D1 was detected by immunohistochemistry and quantitative reverse transcriptase polymerase chain reaction; in situ hybridization for t(11;14) was applied when needed.
  
  
  RESULTS
  Nuclear SOX11 was strongly expressed in most B and T-lymphoblastic leukemia/lymphomas and half of childhood Burkitt's lymphomas, but only weakly expressed in some hairy cell leukemias. Chronic lymphocytic leukemia/lymphoma, marginal zone, follicular and diffuse large B-cell lymphomas were negative for SOX11, as were all cases of intermediate Burkitt's lymphomas/diffuse large B-cell lymphoma, myeloma, Hodgkin's lymphomas and mature T-cell and NK/T-cell lymphomas.
  
  
  CONCLUSIONS
  In addition to mantle cell lymphoma, SOX11 is strongly expressed only in lymphoblastic malignancies and Burkitt's lymphomas. Its expression is independent of cyclin D1 (except for weak expression in hairy cell leukemias) and unlikely to be due to translocations in lymphoid neoplasia.
authors.affiliation: Department of Pathology, Lund University Hospital, Sweden. michael.dictor@med.lu.se
authors.forename: Michael
authors.initials: M
authors.lastname: Dictor
authors.forename: Sara
authors.initials: S
authors.lastname: Ek
authors.forename: Maria
authors.initials: M
authors.lastname: Sundberg
authors.forename: Janina
authors.initials: J
authors.lastname: Warenholt
authors.forename: Czabafy
authors.initials: C
authors.lastname: György
authors.forename: Sandra
authors.initials: S
authors.lastname: Sernbo
authors.forename: Elin
authors.initials: E
authors.lastname: Gustavsson
authors.forename: Waleed
authors.initials: W
authors.lastname: Abu-Alsoud
authors.forename: Torkel
authors.initials: T
authors.lastname: Wadström
authors.forename: Carl
authors.initials: C
authors.lastname: Borrebaeck
mesh_terms: D002051:Burkitt Lymphoma / Q000737:chemistry*; D019938:Cyclin D1 / Q000032:analysis; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D020522:Lymphoma, Mantle-Cell / Q000737:chemistry*; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D055751:SOXC Transcription Factors / Q000032:analysis* / Q000235:genetics
chemical_list: C097473:SOX11 protein, human; D055751:SOXC Transcription Factors; D019938:Cyclin D1