title: Utilizing the FIV model to understand dendritic cell dysfunction and the potential role of dendritic cell immunization in HIV infection.
abstract: Dendritic cells (DC) are potent antigen presenting cells which initiate and coordinate the immune response making them central targets of and attractive candidates for manipulation in chronic lentiviral infections. Emerging evidence suggests that DC immune function is disrupted during both acute and chronic infection with human immunodeficiency virus (HIV), simian immunodeficiency virus (SIV), and feline immunodeficiency virus (FIV). Despite some early promising data, the use of DC for lentiviral immunotherapy has not fulfilled its expected potential and has been complicated by the large number of variables involved in DC harvesting, purifying, and antigen loading. Pre-clinical studies aimed at identifying successful strategies for DC augmentation of current HIV treatment protocols are needed. Over the past two decades, the FIV model for HIV infection has increased the understanding of retroviral pathogenesis, and studies have begun using the FIV model to study DC dysfunction and DC-mediated immunotherapy. Careful consideration of the many variables involved in DC function and therapy should help develop protocols to explore the potential of DC vaccine-based therapies for lentiviral infection.
authors.affiliation: Department of Microbiology, Immunology, and Pathology, Colorado State University, 1619 Campus Delivery, Colorado State University, Fort Collins, CO 80523, USA. tlehman@colostate.edu
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Lehman
authors.forename: Kevin P
authors.initials: KP
authors.lastname: O'Halloran
authors.forename: Edward A
authors.initials: EA
authors.lastname: Hoover
authors.forename: Paul R
authors.initials: PR
authors.lastname: Avery
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology / Q000627:therapeutic use; D000818:Animals; D002415:Cats / Q000821:virology; D003713:Dendritic Cells / Q000276:immunology / Q000821:virology*; D004195:Disease Models, Animal; D016181:Feline Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D006801:Humans; D007114:Immunization / Q000662:veterinary; D016089:Immunodeficiency Virus, Feline / Q000276:immunology* / Q000502:physiology; D016180:Lentivirus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary / Q000821:virology; D014765:Viral Vaccines / Q000276:immunology / Q000627:therapeutic use
chemical_list: D016915:AIDS Vaccines; D014765:Viral Vaccines