The application of NMR spectroscopy to functional glycomics.
Glycomics which is the study of saccharides and genes responsible for their formation requires the continuous development of rapid and sensitive methods for the identification of glycan structures. It involves glycoanalysis which relies upon the development of methods for determining the structure and interactions of carbohydrates. For the application of functional glycomics to microbial virulence, carbohydrates and their associated metabolic and carbohydrate processing enzymes and respective genes can be identified and exploited as targets for drug discovery, glyco-engineering, vaccine design, and detection and diagnosis of diseases. Glycomics also encompasses the detailed understanding of carbohydrate-protein interactions and this knowledge can be applied to research efforts focused toward the development of vaccines and immunological therapies to alleviate infectious diseases.
Brisson
Jean-Robert
JR
Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada.
Vinogradov
Evgeny
E
McNally
David J
DJ
Khieu
Nam Huan
NH
Schoenhofen
Ian C
IC
Logan
Susan M
SM
Jarrell
Harold
H
D001671:Biochemistry / Q000379:methods; D002241:Carbohydrates / Q000737:chemistry; D019286:Endopeptidase K / Q000737:chemistry; D054794:Glycomics / Q000379:methods*; D006020:Glycopeptides / Q000737:chemistry; D006023:Glycoproteins / Q000737:chemistry; D006801:Humans; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods; D011134:Polysaccharides / Q000737:chemistry; D011485:Protein Binding; D012984:Software
D002241:Carbohydrates; D006020:Glycopeptides; D006023:Glycoproteins; D008024:Ligands; D011134:Polysaccharides; D019286:Endopeptidase K