Association of rs2781666 G/T polymorphism of arginase I gene with myocardial infarction in Tunisian male population.
OBJECTIVE
The aim of this study was to investigate the association between rs2781666 G/T polymorphism of arginase I (ARG I) gene and myocardial infarction (MI) in the Tunisian male population.


METHODS
Three hundred eighteen patients with MI and 282 controls were recruited. The rs2781666 G/T polymorphism of ARG I was determined by PCR-RFLP analysis.


RESULTS
Patients had significantly higher frequency of TT genotype compared to controls (10.4% vs. 6.7%; p<0.001). The MI patients showed higher frequency of T allele compared to the controls [0.33 vs. 0.22; OR (95% CI), 1.79 (1.37-2.34), p<0.001]. The association between rs2781666 G/T polymorphism of ARG I gene and MI remained significant after adjustment for other well-established risk factors.


CONCLUSIONS
A significant association between rs2781666 G/T polymorphism of ARG I gene and MI was found in the Tunisian male population.
Sediri
Yousra
Y
LR99ES11 Research Laboratory, Department of Biochemistry, Rabta Hospital, Tunis, Tunisia.
Kallel
Amani
A
Ben Ali
Samir
S
Omar
Souheil
S
Mourali
Mohamed Sami
MS
Elasmi
Monia
M
Taieb
Sameh Haj
SH
Sanhaji
Haïfa
H
Feki
Moncef
M
Mechmeche
Rachid
R
Jemaa
Riadh
R
Kaabachi
Naziha
N
D000328:Adult; D000368:Aged; D001119:Arginase / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014416:Tunisia / Q000453:epidemiology
D001119:Arginase