title: Pattern of disease onset, diagnostic delay, and clinical features in juvenile onset and adult onset ankylosing spondylitis.
abstract: OBJECTIVE
  To assess the frequency of juvenile onset ankylosing spondylitis (JOAS) in Turkish patients with AS and to compare with adult onset AS (AOAS) in a cross-sectional study design.
  
  
  METHODS
  A total of 322 patients were recruited from the joint database of 5 university hospitals in eastern Turkey.
  
  
  RESULTS
  Patients with JOAS (n = 43, 13.4%) had significantly longer diagnostic delay (9.21 vs 5.08 yrs), less severe axial involvement and more prevalent uveitis (OR 2.92, 95% CI 1.25-6.79), and peripheral involvement at onset (OR 3.25, 95% CI 1.51-6.98, adjusted for current age; and OR 2.26, 95% CI 1.07-4.76, adjusted for disease duration). Patients with AOAS had higher radiographic scores and more restricted clinimetrics but similar functional limitations and quality of life.
  
  
  CONCLUSIONS
  JOAS and AOAS had distinctive courses and Turkish patients with AS had similar features compared to other Caucasian patient populations.
authors.affiliation: Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Gevher Nesibe Hospital, Erciyes University, School of Medicine, Kayseri, Turkey. sozgocmen@hotmail.com
authors.forename: Salih
authors.initials: S
authors.lastname: Ozgocmen
authors.forename: Ozge
authors.initials: O
authors.lastname: Ardicoglu
authors.forename: Ayhan
authors.initials: A
authors.lastname: Kamanli
authors.forename: Arzu
authors.initials: A
authors.lastname: Kaya
authors.forename: Bekir
authors.initials: B
authors.lastname: Durmus
authors.forename: Kadir
authors.initials: K
authors.lastname: Yildirim
authors.forename: Ozlem
authors.initials: O
authors.lastname: Baysal
authors.forename: Ali
authors.initials: A
authors.lastname: Gur
authors.forename: Saliha
authors.initials: S
authors.lastname: Karatay
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Altay
authors.forename: Remzi
authors.initials: R
authors.lastname: Cevik
authors.forename: Akin
authors.initials: A
authors.lastname: Erdal
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Ersoy
authors.forename: Aysegul J
authors.initials: AJ
authors.lastname: Sarac
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Tekeoglu
authors.forename: Mahir
authors.initials: M
authors.lastname: Ugur
authors.forename: Kemal
authors.initials: K
authors.lastname: Nas
authors.forename: Kazim
authors.initials: K
authors.lastname: Senel
authors.forename: Hasan
authors.initials: H
authors.lastname: Ulusoy
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D003430:Cross-Sectional Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013167:Spondylitis, Ankylosing / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D014421:Turkey; D055815:Young Adult