title: Sleep disorders in patients with multiple sclerosis.
abstract: Patients with multiple sclerosis (MS) often have unrecognized sleep disorders at higher frequency than the general population. Sleep disorders such as sleep disordered breathing, insomnia, REM sleep behavior disorder, narcolepsy and restless legs syndrome have all been reported in the MS population. Notably, the most common symptom of MS is "fatigue," which itself has been correlated with sleep disturbances. Sleep disorders may impact the quality of life of the MS patient population. This paper reviews the association of sleep disorders with MS, and discusses the association of sleep disruption with MS fatigue.
authors.affiliation: Co-Director of Sleep Medicine, Department of Neurology, UC Davis School of Medicine, 4860 Y Street, Suite 0100, Sacramento, CA 95817, USA. steven.brass@ucdmc.ucdavis.edu
authors.forename: Steven D
authors.initials: SD
authors.lastname: Brass
authors.forename: Pierre
authors.initials: P
authors.lastname: Duquette
authors.forename: Joëlle
authors.initials: J
authors.lastname: Proulx-Therrien
authors.forename: Sanford
authors.initials: S
authors.lastname: Auerbach
mesh_terms: D005221:Fatigue / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications* / Q000503:physiopathology; D020187:REM Sleep Behavior Disorder / Q000209:etiology / Q000503:physiopathology; D012148:Restless Legs Syndrome / Q000209:etiology / Q000503:physiopathology; D012891:Sleep Apnea Syndromes / Q000209:etiology / Q000503:physiopathology; D007319:Sleep Initiation and Maintenance Disorders / Q000209:etiology / Q000503:physiopathology; D012893:Sleep Wake Disorders / Q000209:etiology* / Q000503:physiopathology