Associations of adiponectin with paraoxonase 1 and sE-selectin in hemodialyzed patients.
OBJECTIVE
In hemodialyzed (HD) patients, adiponectin and sE-selectin levels are elevated, while antioxidant paraoxonase 1 activity (PON1) is decreased. We determined if the hyperadiponectinemia in HD patients has a protective effect on the decrease in PON1 and elevation in sE-selectin in kidney failure.


METHODS
Predialysis serum adiponectin, PON1 and sE-selectin as well as other metabolic variables were measured in 70 HD patients.


RESULTS
Adiponectin had (1) no association with PON1 or sE-selectin, (2) a positive association with dialysis efficiency and HDL-C, and (3) an inverse association with BMI, waist circumference, HOMA IR, triglyceride, hsCRP, fibrinogen, and albumin. Moreover, albumin, BMI, and HOMA-IR were independent negative predictors of adiponectin.


CONCLUSIONS
In kidney failure, in contrast to normal renal function, higher adiponectin levels had no correlation with PON1 activity or the sE-selectin level. However, adiponectin has an association with dialysis efficiency and, similar to individuals with preserved kidney function, traits of metabolic syndrome. In addition to BMI and HOMA-IR, the serum albumin concentration is also one of the independent negative predictors of the serum adiponectin level. Collectively, these findings may add details to the understanding of the role that adiponectin plays in chronic renal disease related to 'reverse epidemiology'.
Peti
Attila
A
Institute of Laboratory Medicine, University of Pecs, Pecs, Hungary.
Csiky
Botond
B
Guth
Eszter
E
Kenyeres
Peter
P
Varga
Zsuzsa
Z
Seres
Ildiko
I
Jeney
Zoltan
Z
Juhasz
Maria
M
Mezosi
Emese
E
Paragh
Gyorgy
G
Kovacs
Gabor L
GL
Bajnok
Laszlo
L
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D043303:Aryldialkylphosphatase / Q000097:blood*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D003430:Cross-Sectional Studies; D019040:E-Selectin / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000097:blood* / Q000628:therapy*; D014280:Triglycerides / Q000097:blood
D052242:Adiponectin; D019040:E-Selectin; D014280:Triglycerides; D005340:Fibrinogen; D002097:C-Reactive Protein; D043303:Aryldialkylphosphatase