title: Development of the stapedius muscle and unilateral agenesia of the tendon of the stapedius muscle in a human fetus.
abstract: The objective was to analyze the development of the stapedius muscle to understand an isolated unilateral absence of the tendon of the stapedius muscle in a human fetus. The study was made on 50 human embryos and fetuses aged 38 days to 17 weeks post-conception. The stapedius muscle was formed by two anlagen, one for the tendon, which derives from the internal segment of the interhyale and another for the belly, located in the second pharyngeal arch, medially to the facial nerve and near the interhyale. In the interhyale, two segments were observed forming an angle and delimited by the attachment of the belly of the stapedius muscle. The internal segment will form the tendon. The lateral segment of the interhyale was attached to the cranial end of the Reichert's cartilage (laterohyale), and normally it disappears at the beginning of the fetal period. The right unilateral agenesia of the tendon of the stapedius muscle, observed for the first time in a human fetus of 14 weeks post-conception development (PCd), was brought about by the lack of formation or the regression of the internal segment of the interhyale. It presented a belly of the stapedius muscle with an anomalous arrangement, and with a pseudo tendon originated by the persistence of the external segment of the interhyale.
authors.affiliation: Departamento de Anatomía y Embriología Humana II, Facultad de Medicina, Universidad Complutense, Madrid, España. jfrodvaz@med.ucm.es
authors.forename: J F
authors.initials: JF
authors.lastname: Rodríguez-Vázquez
authors.forename: J R
authors.initials: JR
authors.lastname: Mérida-Velasco
authors.forename: S
authors.initials: S
authors.lastname: Verdugo-López
mesh_terms: D001934:Branchial Region / Q000196:embryology; D005260:Female; D005865:Gestational Age; D006801:Humans; D024510:Muscle Development; D011712:Pyramidal Tracts / Q000196:embryology; D013198:Stapedius / Q000196:embryology*; D013710:Tendons / Q000002:abnormalities* / Q000294:innervation