The role of autophagy in Paneth cell differentiation and secretion.
Paneth cells are a small intestinal epithelial cell lineage that is considered to have a role in innate immune function. Recent studies on mice with diminished and/or loss of autophagy have suggested that Paneth cells are a primary target in vivo. Interestingly, loss of autophagy affects the secretion of antimicrobial proteins from Paneth cells. Understanding the intersection of the autophagy pathway with the secretory apparatus, which is a key feature of differentiation of Paneth cells, is a key unanswered question.
Stappenbeck
T S
TS
Department of Pathology and Immunology Washington University School of Medicine, St Louis, MO, USA. stappenb@pathology.wustl.edu
D000818:Animals; D001343:Autophagy / Q000502:physiology*; D000071183:Autophagy-Related Proteins; D012634:Bodily Secretions / Q000502:physiology; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation; D003424:Crohn Disease / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D020022:Genetic Predisposition to Disease; D054884:Host-Pathogen Interactions; D006801:Humans; D007421:Intestine, Small / Q000473:pathology; D051379:Mice; D019879:Paneth Cells / Q000502:physiology*; D011110:Polymorphism, Genetic; D012259:Ribonuclease, Pancreatic / Q000378:metabolism; D051193:Toll-Like Receptors / Q000378:metabolism
C518959:ATG16L1 protein, human; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins; D051193:Toll-Like Receptors; C519253:Ang4 protein, mouse; D012259:Ribonuclease, Pancreatic