title: Neuronal degeneration and microglial activation in the ischemic dentate gyrus of the gerbil.
abstract: In the present study, we investigated the time-course changes of neuronal degeneration and microglial activation in the gerbil dentate gyrus after transient cerebral ischemia using Fluoro-Jade B histofluorescence staining and immunohistochemistry for Iba-1. Fluoro-Jade B positive cells were observed from 6 hr and markedly increased 1 day after ischemia/reperfusion. Iba-1-immunoreactive microglia were increased and hypertrophied at early time, and Iba-1 immunoreactivity was highest at 2 days after ischemia/reperfusion. These results may be direct evidence on neuronal degeneration and microglial activation in the gerbil dentate gyrus after ischemia/reperfusion.
authors.affiliation: Department of Emergency Medicine, College of Medicine, Kangwon National University, Chuncheon 200-702, South Korea.
authors.forename: Joong Bum
authors.initials: JB
authors.lastname: Moon
authors.forename: Choong Hyun
authors.initials: CH
authors.lastname: Lee
authors.forename: Chan Woo
authors.initials: CW
authors.lastname: Park
authors.forename: Jun Hwi
authors.initials: JH
authors.lastname: Cho
authors.forename: In Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Ki-Yeon
authors.initials: KY
authors.lastname: Yoo
authors.forename: Jung Hoon
authors.initials: JH
authors.lastname: Choi
authors.forename: Hyung-Cheul
authors.initials: HC
authors.lastname: Shin
authors.forename: Moo-Ho
authors.initials: MH
authors.lastname: Won
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000473:pathology*; D018891:Dentate Gyrus / Q000098:blood supply / Q000473:pathology*; D005849:Gerbillinae; D017628:Microglia / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D015427:Reperfusion Injury / Q000473:pathology*