title: Computation of the asymptotic null distribution of goodness-of-fit tests for multi-state models.
abstract: We develop an improved approximation to the asymptotic null distribution of the goodness-of-fit tests for panel observed multi-state Markov models (Aguirre-Hernandez and Farewell, Stat Med 21:1899-1911, 2002) and hidden Markov models (Titman and Sharples, Stat Med 27:2177-2195, 2008). By considering the joint distribution of the grouped observed transition counts and the maximum likelihood estimate of the parameter vector it is shown that the distribution can be expressed as a weighted sum of independent chi(1)(2) random variables, where the weights are dependent on the true parameters. The performance of this approximation for finite sample sizes and where the weights are calculated using the maximum likelihood estimates of the parameters is considered through simulation. In the scenarios considered, the approximation performs well and is a substantial improvement over the simple chi(2) approximation.
authors.affiliation: Department of Mathematics and Statistics, Lancaster University, Lancaster LA1 4YF, UK. a.titman@lancaster.ac.uk
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Titman
mesh_terms: D000465:Algorithms; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D018450:Disease Progression; D008390:Markov Chains; D015233:Models, Statistical; D019370:Observation