title: Psychological well-being in advanced NSCLC patients in Serbia: impact of sociodemographic and clinical factors.
abstract: Patients with advanced non-small cell lung cancer (NSCLC) usually undergo toxic treatment (chemotherapy and/or radiotherapy). They can experience devastating effects of illness and therapies on their psychological and emotional well-being. On the other hand, untreated psychological distress is associated with reduced quality of life and inadequate palliation of physical symptoms.<br />In order to estimate frequency of anxiety and depressive symptoms and influence of demographic, socioeconomic and clinical factors on psychological well-being, we performed this cross-sectional study in group of 100 patients with advanced stage of disease. Symptoms of anxiety and depression were assessed using the Hamilton Anxiety Rating Scale (HARS) and Hamilton Depression Rating scale (HDRS). Health-related quality of life data are obtained by EORTC QLC C30 and SF 36.<br />Patients with poor performance status (PS) experienced significantly more anxiety and depressive symptoms (p=0.001) and worse emotional (p=0.001) and mental functioning (p=0.001). Treated patients had significantly better mental (p=0.011) and emotional (p=0.001) functioning in compared to newly diagnosed ones. Somewhat unusual, unemployed participants reported significantly less anxiety (p=0.029) and depressive (p=0.002) symptoms, better mental (p=0.030) and emotional functioning (p=0.007). Additionally, nausea and vomiting adversely affected mental health and emotional functioning and correlated significantly positively with HARS and HDRS scores.<br />Our findings suggest significant impact of some disease-related factors (PS, active treatment) and treatment-related factors (chemotherapy -induced nausea and vomiting) on psychological well-being of patients with advanced NSCLC. This should be taking an account when appropriate interventions are planned.
  
  
  BACKGROUND
  lung cancer, anxiety, depression, quality of life, chemotherapy, chemotherapy-induced nausea and vomiting.
authors.affiliation: Institute for Lung Diseases and Tuberculosis, Clinical Center of Serbia, Belgrade. draganamaric@msn.com
authors.forename: D M
authors.initials: DM
authors.lastname: Maric
authors.forename: D M
authors.initials: DM
authors.lastname: Jovanovic
authors.forename: I V
authors.initials: IV
authors.lastname: Golubicic
authors.forename: L J
authors.initials: LJ
authors.lastname: Nagorni-Obradovic
authors.forename: J M
authors.initials: JM
authors.lastname: Stojsic
authors.forename: T D
authors.initials: TD
authors.lastname: Pekmezovic
mesh_terms: D000367:Age Factors; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D001007:Anxiety / Q000209:etiology; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000523:psychology*; D003430:Cross-Sectional Studies; D003863:Depression / Q000209:etiology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D055771:Serbia; D012737:Sex Factors
chemical_list: D000970:Antineoplastic Agents