title: Subconjunctival application of regenerative factor-rich plasma for the treatment of ocular alkali burns.
abstract: OBJECTIVE
  To study the efficiency of the subconjunctival application of autologous regenerative factor-rich plasma (RFRP) in patients with different degrees of ocular alkali burns.
  
  
  METHODS
  Thirty-five eyes of 35 patients with ocular alkali burns were analyzed. They were classified into moderate and relevance groups according to the severity of the burn. A control group was established for each with conventional topical medical treatment; subconjunctival regenerative factor rich plasma (RFRP) was applied to the other groups. A further group was added to the severe chemical burn group, which received autohemotherapy. The clinical evolution of the lesions and the period in which the pathology prevented the patient from working were studied; monitoring was carried out until the patient had healed.
  
  
  RESULTS
  In the moderate chemical burns, there was a significant reduction in corneal and conjunctival epithelization times, sick leave duration, and healing time when the patients were treated with RFRP in comparison to the control group. With regard to the severe burns, significant reduction in time to corneal scarring in those treated with RFRP in comparison to traditional treatment was reported. RFRP showed, at least as effective and less side effects than the autohemotherapy.
  
  
  CONCLUSIONS
  Subconjunctival infiltration with autologous RFRP can be considered an effective, straightforward, and economical form of treatment for burns of the ocular surface.
authors.affiliation: Hospital FREMAP, Sevilla and Universidad de Sevilla - Spain. rafael_marquez@fremap.es
authors.forename: Rafael
authors.initials: R
authors.lastname: Marquez De Aracena Del Cid
authors.forename: Ignacio
authors.initials: I
authors.lastname: Montero De Espinosa Escoriaza
mesh_terms: D000328:Adult; D000468:Alkalies / Q000037:antagonists & inhibitors*; D002057:Burns, Chemical / Q000145:classification / Q000503:physiopathology / Q000628:therapy*; D003228:Conjunctiva / Q000502:physiology*; D003315:Cornea / Q000502:physiology*; D004185:Disability Evaluation; D004847:Epithelial Cells / Q000502:physiology; D005126:Eye Burns / Q000139:chemically induced* / Q000145:classification / Q000503:physiopathology; D006801:Humans; D008297:Male; D053657:Platelet-Rich Plasma; D012038:Regeneration; D018582:Sick Leave; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*
chemical_list: D000468:Alkalies