title: Lack of association between antipsychotic-induced extrapyramidal symptoms and polymorphisms in dopamine metabolism and transport genes.
abstract: The purpose of this study was to investigate the relationship between functional polymorphisms in genes coding for dopamine metabolism and transport enzymes and the incidence of acute antipsychotic (AP)-induced extrapyramidal symptoms (EPS). We did not find evidence of the involvement of these polymorphisms in the predisposition towards or protection from EPS.
authors.affiliation: Dept. Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Barcelona, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Gassó
authors.forename: Sergi
authors.initials: S
authors.lastname: Mas
authors.forename: Anna
authors.initials: A
authors.lastname: Crescenti
authors.forename: Santi
authors.initials: S
authors.lastname: Alvarez
authors.forename: Gemma
authors.initials: G
authors.lastname: Parramon
authors.forename: Clemente
authors.initials: C
authors.lastname: Garcia-Rizo
authors.forename: Eduard
authors.initials: E
authors.lastname: Parellada
authors.forename: Miquel
authors.initials: M
authors.lastname: Bernardo
authors.forename: Amalia
authors.initials: A
authors.lastname: Lafuente
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D001480:Basal Ganglia Diseases / Q000139:chemically induced* / Q000235:genetics*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy; D018598:Minisatellite Repeats / Q000235:genetics; D008995:Monoamine Oxidase / Q000235:genetics*; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic / Q000235:genetics*; D012189:Retrospective Studies
chemical_list: D014150:Antipsychotic Agents; D050483:Dopamine Plasma Membrane Transport Proteins; D008995:Monoamine Oxidase