Continuous orally administered coffee enhanced the antigen-specific Th1 response and reduced allergic development in a TCR-transgenic mice model.
Coffee is a globally consumed beverage. Although recent studies have suggested that coffee reduced the risk of lifestyle-related diseases, there are few studies regarding allergic response. This study investigates the effects of orally administered coffee (91 ml/kg/d) on allergic responses using a T cell receptor (TCR)-transgenic DO11.10 mouse allergic model. Splenocytes from coffee-administered naïve mice increased antigen (Ag)-specific interleukin (IL)-12p40 secretion. When Ag sensitization and coffee administration were concurrently performed, the splenocytes from coffee-administered mice showed a decrease of IL-2 and an increase of IL-12p40 secretion. The Ag-specific cutaneous response and serum IgE level were reduced in coffee-administered mice, although, after establishing the allergy, coffee administration did not suppress the allergic reaction. These results suggest that coffee could induce a Th1-type response of the immune system and prevent an allergy developing. Further studies on the optimum dose, cultivar differences, and roasted degree need to be undertaken.
Goto
Masao
M
National Agriculture and Food Research Organization National Food Research Institute, Tsukuba, Ibaraki, Japan.
Yamaki
Kohji
K
Shinmoto
Hiroshi
H
Takano-Ishikawa
Yuko
Y
D000284:Administration, Oral; D000707:Anaphylaxis / Q000276:immunology; D000818:Animals; D000941:Antigens / Q000276:immunology*; D001835:Body Weight / Q000276:immunology; D003069:Coffee / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis; D004195:Disease Models, Animal; D000939:Epitopes; D005260:Female; D006967:Hypersensitivity / Q000276:immunology* / Q000517:prevention & control*; D007114:Immunization; D007136:Immunoglobulins / Q000097:blood; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D018417:Th1 Cells / Q000276:immunology*
D000941:Antigens; D003069:Coffee; D016207:Cytokines; D000939:Epitopes; D007136:Immunoglobulins; D011948:Receptors, Antigen, T-Cell