title: How to control miRNA maturation?
abstract: In this point of view we discuss the role of co-activators and co-repressors of miRNA precursors maturation, the possibility that their functions are post translationally regulated by different signaling pathways, and their potential role in the miRNA-dependent control of cell proliferation and differentiation.
authors.affiliation: Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Michele
authors.initials: M
authors.lastname: Trabucchi
authors.forename: Paola
authors.initials: P
authors.lastname: Briata
authors.forename: Witold
authors.initials: W
authors.lastname: Filipowicz
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rosenfeld
authors.forename: Andres
authors.initials: A
authors.lastname: Ramos
authors.forename: Roberto
authors.initials: R
authors.lastname: Gherzi
mesh_terms: D002454:Cell Differentiation; D049109:Cell Proliferation; D056970:Co-Repressor Proteins / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D012322:RNA Precursors / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D043244:Ribonuclease III / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology
chemical_list: D056970:Co-Repressor Proteins; D035683:MicroRNAs; D012322:RNA Precursors; D014157:Transcription Factors; C517918:DROSHA protein, human; D043244:Ribonuclease III