title: Transarterial Chemoembolization of Metastatic Colorectal Carcinoma with Drug-Eluting Beads, Irinotecan (DEBIRI): Multi-Institutional Registry.
abstract: The purpose of this study was to evaluate the patient tolerance and efficacy of delivering locoregional chemotherapy to metastatic colorectal (MC) hepatic metastases via hepatic trans-arterial approach using irinotecan loaded drug eluting beads. This open-label, multi-center, single arm study included 30 MC patients, who had failed first line therapy. Of the 57 total embolization sessions, 12 (21% of sessions) were associated with adverse reactions during or after the treatment. After a median followup of 9 months, response rates by modified RECIST were 75% at 3 months and 66% at 6 months. Hepatic trans-arterial therapy using Irinotecan loaded DC Bead(TM) was safe and effective in the treatment of MCC as demonstrated by a minimal complication rate and acceptable tumor response.
authors.affiliation: Division of Surgical Oncology, University of Louisville School of Medicine, 315 East Broadway-Rm 311, Louisville, KY 40292, USA.
authors.forename: Robert C G
authors.initials: RC
authors.lastname: Martin
authors.forename: Jonathan
authors.initials: J
authors.lastname: Joshi
authors.forename: Ken
authors.initials: K
authors.lastname: Robbins
authors.forename: Dana
authors.initials: D
authors.lastname: Tomalty
authors.forename: Ryan
authors.initials: R
authors.lastname: O'Hara
authors.forename: Cliff
authors.initials: C
authors.lastname: Tatum