title: Risk of ovarian failure and fertility preserving methods in girls and adolescents with a malignant disease.
abstract: Girls and young women suffering from a malignant disease that requires treatment with chemo- and/or radiotherapy are at risk of losing fertility. The most significant risk factors are age and type of treatment given. Preserving fertility is of high priority to both the young patient and her parents. This article reviews the effect of chemo- and radiotherapy on gonadal function, and thus fertility, and offers different fertility preserving methods based on the literature. Cryopreservation of ovarian tissue is a possible way of preserving fertility in this group of patients in the future.
authors.affiliation: The Fertility Clinic, Biology, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark. kirsten.tryde.schmidt@rh.regionh.dk
authors.forename: K T
authors.initials: KT
authors.lastname: Schmidt
authors.forename: E C
authors.initials: EC
authors.lastname: Larsen
authors.forename: C Y
authors.initials: CY
authors.lastname: Andersen
authors.forename: A N
authors.initials: AN
authors.lastname: Andersen
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects; D002648:Child; D015925:Cryopreservation; D003718:Denmark; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000528:radiation effects; D005307:Fertilization in Vitro; D006801:Humans; D007223:Infant; D007247:Infertility, Female / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D008297:Male; D008572:Menarche / Q000187:drug effects / Q000528:radiation effects; D009369:Neoplasms / Q000628:therapy; D054315:Oocyte Retrieval / Q000379:methods; D009865:Oocytes / Q000254:growth & development / Q000637:transplantation; D009926:Organ Preservation / Q000379:methods*; D006080:Ovarian Follicle / Q000187:drug effects / Q000528:radiation effects; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000209:etiology* / Q000628:therapy; D011627:Puberty / Q000187:drug effects / Q000528:radiation effects; D011832:Radiation Injuries / Q000150:complications / Q000517:prevention & control; D017741:Survivors / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D018906:Antineoplastic Agents, Alkylating