title: Small intestinal malabsorption in chronic alcoholism determined by 13C-D-xylose breath test and microscopic examination of the duodenal mucosa.
abstract: OBJECTIVE
  Diarrhea, weight loss and osteoporosis are prominent symptoms and clinical signs of alcoholism. One of several possible factors causing this clinical picture is small intestinal damage leading to malabsorption. The aim of this study was to prospectively evaluate small intestinal absorption in alcoholics using the (13)C-D-xylose breath test, and to relate the breath test results to morphological findings of the duodenal mucosa.
  
  
  METHODS
  Sixteen alcoholics without liver failure or serious illness and presenting symptoms of dyspepsia, nausea or diarrhea were included. The (13)C-D-xylose breath test was performed in 14 of the included subjects. The breath tests of the alcoholics were compared to those of untreated coeliac patients and healthy subjects. Duodenal biopsy specimens were taken for assessment of epithelial morphology in 14 of the included subjects, using light- and electron microscopic techniques.
  
  
  RESULTS
  Alcoholics had significantly reduced absorption of (13)C-D-xylose compared to healthy subjects. The time curve of (13)C-D-xylose absorption in the group of alcoholics was similar in appearance to that of untreated coeliac patients. Alcoholic patients had few light microscopic changes, but electron microscopic examination exposed morphological pathology in the majority of the patients, with a reduced surface area of microvilli as the main finding.
  
  
  CONCLUSIONS
  Alcoholics have a pathological (13)C-D-xylose breath test with a time curve similar to that of untreated coeliac patients. This implies a condition of malabsorption. The morphological pathology found included a reduced absorptive area due to pathology of microvilli. These findings may explain our breath test results.
authors.affiliation: Department of Medicine, Lovisenberg Diakonale Hospital, Oslo, Norway. hbho@lds.no
authors.forename: Haavar Blich
authors.initials: HB
authors.lastname: Hope
authors.forename: Kari
authors.initials: K
authors.lastname: Tveito
authors.forename: Steinar
authors.initials: S
authors.lastname: Aase
authors.forename: Edvard
authors.initials: E
authors.lastname: Messelt
authors.forename: Peter
authors.initials: P
authors.lastname: Utzon
authors.forename: Viggo
authors.initials: V
authors.lastname: Skar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000150:complications*; D001944:Breath Tests; D016022:Case-Control Studies; D004386:Duodenum / Q000473:pathology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D008286:Malabsorption Syndromes / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014994:Xylose
chemical_list: D014994:Xylose