title: Elevated serum concentrations of troponin T in acute stroke: what do they mean?
abstract: Elevations in serum troponin T in acute stroke have been suggested as an early marker of a poor outcome. A prospective, case-control study was undertaken to define characteristics associated with elevations in troponin T concentrations. Consecutive admissions to the Royal Adelaide stroke unit were assessed. Stroke outcome was determined using the modified Rankin scale. Elevated serum troponin T was seen in 12/109 (11%) of patients with stroke and was associated with more severe stroke, larger lesion volume and a worse outcome. However, as a prognostic indicator, elevations in troponin T had lower sensitivity for predicting death or dependence at discharge than the National Institute of Health Stroke Scale. Troponin T levels are elevated in a significant proportion of patients with acute stroke, principally those with large infarcts affecting the territory supplied by the middle cerebral artery but their value as a prognostic indicator remains uncertain.
authors.affiliation: Department of Neurology, Royal Adelaide Hospital, Adelaide, Australia.
authors.forename: Joanna
authors.initials: J
authors.lastname: Ghali
authors.forename: Dale
authors.initials: D
authors.lastname: Allison
authors.forename: Timothy
authors.initials: T
authors.lastname: Kleinig
authors.forename: Soon Yen
authors.initials: SY
authors.lastname: Ooi
authors.forename: Shalini
authors.initials: S
authors.lastname: Bastiampillai
authors.forename: Dale
authors.initials: D
authors.lastname: Ashby
authors.forename: James
authors.initials: J
authors.lastname: Taylor
authors.forename: Philip D
authors.initials: PD
authors.lastname: Thompson
authors.forename: Simon A
authors.initials: SA
authors.lastname: Broadley
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001921:Brain / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D020107:Troponin T / Q000032:analysis / Q000097:blood*; D015854:Up-Regulation / Q000502:physiology
chemical_list: D015415:Biomarkers; D020107:Troponin T