Effect of recombinant basic fibroblast growth factor on reimplanted teeth in beagle dogs.
OBJECTIVE
This study assessed the effect of recombinant fibroblast growth factor (FGF-2) on reimplanted teeth.


METHODS
Premolars were reimplanted in dogs. Roots on the left side of the mandible were treated with FGF-2, whereas roots on right side served as controls. At 2, 4, or 8 weeks after treatment, animals were humanely killed and specimens collected and processed for histopathologic examination.


RESULTS
After 2 weeks, proliferating cell nuclear antigen-positive cell ratios in the experimental group were significantly greater than those in the control group (P < .01). After 4 and 8 weeks, the experimental group showed formation of new cementum. Moreover, incidence of replacement resorption in the experimental group was significantly lower than that in the control group (P < .01).


CONCLUSIONS
The results indicate that FGF-2 promotes formation of new periodontal ligament and prevents ankylosis and root resorption following reimplantation of teeth.
Seshima
Fumi
F
Resident, Department of Periodontics, Tokyo Dental College, Chiba, Japan. seshimaf@tdc.ac.jp
Ota
Mikio
M
Kinumatsu
Takashi
T
Shibukawa
Yoshihiro
Y
Yamada
Satoru
S
D000818:Animals; D003739:Dental Cementum / Q000187:drug effects / Q000502:physiology; D004285:Dogs; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D006133:Growth Substances / Q000494:pharmacology*; D007124:Immunoenzyme Techniques; D010513:Periodontal Ligament / Q000187:drug effects / Q000502:physiology; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis / Q000096:biosynthesis; D011994:Recombinant Proteins / Q000494:pharmacology; D012038:Regeneration / Q000187:drug effects*; D012391:Root Resorption / Q000517:prevention & control; D020254:Tooth Ankylosis / Q000517:prevention & control; D014090:Tooth Replantation
D006133:Growth Substances; D018809:Proliferating Cell Nuclear Antigen; D011994:Recombinant Proteins; D016222:Fibroblast Growth Factor 2