title: [Signal transudation pathways in parietal cells of the gastric mucosa in experimental stomach ulcer].
abstract: The goal of the presented work was the research of signal transduction mechanism in the rat gastric parietal cells under stomach ulcer conditions. In these cells activation of adenylate cyclase (increase of cAMP level and proteinkinase A activity) and phosphoinositide (increases [Ca2+]i; cGMP and phoshatidylinocitole levels; proteinkinase C, proteinkinase G, and calmodulin-dependent-proteinkinase activity) of signals pathway was shown. An increase of plasma membrane phospholipids (PC, PS, PE, PI, LPC) level was shown. Under conditions of influence of the stress factor the membran enzymes activity (H+, K+ -ATPase, 5'-AMPase, Na+, K+ -ATPase, Ca2+, Mg2+ -ATPase and H+, K+ -ATPase) was considerably increased. The intensification of lipid peroxidation processes in rats was demonstrated.
authors.forename: L I
authors.initials: LI
authors.lastname: Ostapchenko
authors.forename: O V
authors.initials: OV
authors.lastname: Drobins'ka
authors.forename: V O
authors.initials: VO
authors.lastname: Chaĭka
authors.forename: L I
authors.initials: LI
authors.lastname: Bohun
authors.forename: O V
authors.initials: OV
authors.lastname: Bohdanova
authors.forename: L I
authors.initials: LI
authors.lastname: Kot
authors.forename: L M
authors.initials: LM
authors.lastname: Haĭda
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D015227:Lipid Peroxidation; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D010295:Parietal Cells, Gastric / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D012149:Restraint, Physical; D015398:Signal Transduction; D013276:Stomach Ulcer / Q000201:enzymology / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D013315:Stress, Psychological / Q000150:complications / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; D017382:Reactive Oxygen Species; D000242:Cyclic AMP; D000251:Adenosine Triphosphatases; D006152:Cyclic GMP