title: Leptomeningeal myeloma as the sole manifestation of relapse: an unusual presentation.
abstract: We report a case of a 57-year-old African American male patient with standard risk (IIIA) IgA kappa multiple myeloma. This patient presented with neurologic complaints (manifesting as generalized muscle weakness and swallowing dysfunction associated with a poor cough reflex) 10 months after achieving a very good partial remission and without evidence of systemic progression. Examination of the cerebrospinal fluid revealed leptomeningeal involvement. Very little is known about the mechanisms of myelomatous spread to the leptomeninges, a very rare event, and the presentation of this case could raise awareness of this rare complication in those involved in caring for patients with multiple myeloma.
authors.affiliation: Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.
authors.forename: Abdul Rahman
authors.initials: AR
authors.lastname: Mourad
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Kharfan-Dabaja
authors.forename: Kaaron
authors.initials: K
authors.lastname: Benson
authors.forename: Lynn C
authors.initials: LC
authors.lastname: Moscinski
authors.forename: Rachid C
authors.initials: RC
authors.lastname: Baz
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000209:etiology* / Q000517:prevention & control; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis*; D055502:Secondary Prevention