Migraine and vasodepressor syncope in a large family.
We evaluated a 47-year-old woman for recurrent migraine and syncope. The patient had 7 children (not examined by the authors), all of whom also experienced migraine and syncope. The patient's father, now deceased, had reportedly experienced migraine and episodes of feeling faint. All 5 of the patient's siblings reported migraine, and 4 of the 5 reported syncope. The case of our patient, which we discuss herein, suggests a genetic link between these 2 conditions, both of which include vascular dysregulation in their pathogenesis. To our knowledge, the medical literature contains no previous description of familial associations of combined migraine and syncope.
Paisley
Robert D
RD
Department of Cardiology, Texas Heart Institute at St. Luke's Episcopal Hospital, and University of Texas Medical School at Houston, Houston, Texas 77030, USA.
Arora
Harvinder S
HS
Nazeri
Alireza
A
Massumi
Ali
A
Razavi
Mehdi
M
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D010375:Pedigree; D012008:Recurrence; D012307:Risk Factors; D019462:Syncope, Vasovagal / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D055815:Young Adult