title: The Inhibitory Effect of Quercetin-3-O-beta-D-Glucuronopyranoside on Gastritis and Reflux Esophagitis in Rats.
abstract: It was evaluated the inhibitory action of quercetin-3-O-beta-D-glucuronopyranoside (QGC) on reflux esophagitis and gastritis in rats. QGC was isolated from the herba of Rumex Aquaticus. Reflux esophagitis or gastritis was induced surgically or by administering indomethacin, respectively. Oral QGC decreased ulcer index, injury area, gastric volume, and acid output and increased gastric pH as compared with quercetin. Furthermore, QGC significantly decreased gastric lesion sizes induced by exposing the gastric mucosa to indomethacin. Malondialdehyde levels were found to increase significantly after inducing reflux esophagitis, and were reduced by QGC, but not by quercetin or omeprazole. These results show that QGC can inhibit reflux esophagitis and gastritis in rats.
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Young Sil
authors.initials: YS
authors.lastname: Min
authors.forename: Se Eun
authors.initials: SE
authors.lastname: Lee
authors.forename: Seung Tae
authors.initials: ST
authors.lastname: Hong
authors.forename: Hyun Sik
authors.initials: HS
authors.lastname: Kim
authors.forename: Byung-Chul
authors.initials: BC
authors.lastname: Choi
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Sim
authors.forename: Wan Kyun
authors.initials: WK
authors.lastname: Whang
authors.forename: Uy Dong
authors.initials: UD
authors.lastname: Sohn