title: Fatal liver injury associated with clopidogrel.
abstract: Clopidogrel, an adenosine diphosphate receptor blocker, is widely used as an adjunctive antiplatelet therapy in acute coronary syndrome and percutaneous coronary stenting. It appears to be a safe drug with few occurrences of liver side-effects that usually resolved after drug withdrawal. We report a serious liver injury with fatal outcome in a 63-year-old man developed 19 days after starting clopidogrel for percutaneous coronary stenting.
authors.affiliation: Centre National de Pharmacovigilance, 9 Avenue du Dr Zouheir Essafi 1006 Tunis, Tunisia.
authors.forename: Sarrah
authors.initials: S
authors.lastname: Kastalli
authors.forename: Sihem
authors.initials: S
authors.lastname: El Aïdli
authors.forename: Ahmed
authors.initials: A
authors.lastname: Zaïem
authors.forename: Hatem
authors.initials: H
authors.lastname: ben Abdallah
authors.forename: Riadh
authors.initials: R
authors.lastname: Daghfous
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000209:etiology*; D000077144:Clopidogrel; D017809:Fatal Outcome; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D013988:Ticlopidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine