Type B3 thymic epithelial tumor in an adolescent detected by immunohistochemical staining for CD5, CD99, and KIT (CD117): a case report.
A 16-year-old male patient was admitted to the hospital for a medical workup to examine an anterior mediastinal tumor in April 2000. A tumor excision and a right lower lung lobe nodule resection were performed in June 2000. The tumor tissue showed a cobblestone-like proliferation of atypical cells containing a discrete nucleolus that were aligned in an epithelial fashion against mainly lymphocytic inflammatory cells in the background; also shown were undifferentiated tumor cells with epithelioid characteristics. Immunohistochemical staining for CD5, CD99, and KIT (CD117) revealed that the tumor cells were CD5-negative and that some of the lymphocytes infiltrating the tumor tissue stained positive for CD99 and negative for KIT. The lesion was therefore diagnosed to be a type B3 thymic epithelial tumor.
Yoshino
Naoyuki
N
Department of Surgery, Division of Thoracic Surgery, Nippon Medical School, Tokyo, Japan.
Kubokura
Hirotoshi
H
Yamauchi
Shigeo
S
Oaki
Yoshiharu
Y
Koizumi
Kiyoshi
K
Shimizu
Kazuo
K
D000071443:12E7 Antigen; D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis*; D018956:CD5 Antigens / Q000032:analysis*; D015815:Cell Adhesion Molecules / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis*; D013945:Thymoma / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D013953:Thymus Neoplasms / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed
D000071443:12E7 Antigen; D015703:Antigens, CD; D018956:CD5 Antigens; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D019009:Proto-Oncogene Proteins c-kit