title: A KIT-positive gastrointestinal stromal tumor in a ferret (Mustela putorius furo).
abstract: A 1.5-year-old, neutered, male ferret (Mustela putorius furo) was presented with sudden lethargy, anorexia, and diarrhea. Clinical and radiographic examinations revealed an intra-abdominal mass. An explorative laparotomy was performed. A neoplasm, located in the ileum wall, was submitted for histopathologic examination. The tumor consisted of weakly eosinophilic spindle cells arranged in a compact pattern with haphazardly interlacing bundles. Neoplastic cells labeled positively for KIT (cluster of differentiation 117, stem cell factor receptor) and vimentin. Based on histologic and immunohistologic results, this tumor was diagnosed as a gastrointestinal stromal tumor. Results suggest that this ferret tumor shares strong similarities with the canine and human counterparts.
authors.affiliation: Unité d'Embryologie, d'Histologie et d'Anatomie Pathologique and INRA UMR 955, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort Cedex, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Girard-Luc
authors.forename: Daniela
authors.initials: D
authors.lastname: Prata
authors.forename: Hélène
authors.initials: H
authors.lastname: Huet
authors.forename: Marie
authors.initials: M
authors.lastname: Lagadic
authors.forename: Florence
authors.initials: F
authors.lastname: Bernex
mesh_terms: D000818:Animals; D000855:Anorexia / Q000209:etiology / Q000662:veterinary; D003967:Diarrhea / Q000209:etiology / Q000662:veterinary; D004283:Dog Diseases / Q000473:pathology; D004285:Dogs; D005289:Ferrets; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology / Q000662:veterinary*; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology / Q000662:veterinary; D007413:Intestinal Mucosa / Q000473:pathology; D053609:Lethargy / Q000209:etiology / Q000662:veterinary; D008297:Male; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis*; D013045:Species Specificity
chemical_list: D019009:Proto-Oncogene Proteins c-kit