[Advance on oxidative stress mechanism of arsenic toxicology].
Inorganic arsenic is one of proven human carcinogens, which there are so far no sound laboratory-based evidences and there are very few reports in the literature regarding arsenic carcinogenic effects in in vivo animal experiment. Because of this lack of adequate evidences, the mechanism for understanding arsenic toxicology remains vague. Recently, many modes of action for arsenic carcinogenesis have been proposed, oxidative stress is one of the stronger theories of arsenic action modes which have a substantial mass of supporting data. Further more, many researchers have pointed out that induction of oxidative stress by methylated metabolites of inorganic arsenics plays an important role in the toxicity and carcinogenicity of arsenics. The role of oxidative stress induced by arsenic in arsenic toxicology was reviewed.
Li
Zhen
Z
Department of Radiation Effect, Institute of Radiation Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China.
An
Yan
Y
D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*
D002273:Carcinogens; D001151:Arsenic