History matters: illuminating metaplasticity in the developing brain.
Metaplasticity refers to an activity-dependent regulation of the plastic state of neurons. In this issue of Neuron, Dunfield and Haas demonstrate that in intact developing brain circuits, specific patterns of visual stimulation drive functional plasticity of individual neurons with variable outcomes, predisposed by time-averaged postsynaptic activity recent to visual training.
Wang
Sheng-Zhi
SZ
Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Tao
Huizhong Whit
HW
D000818:Animals; D001921:Brain / Q000166:cytology* / Q000196:embryology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D014795:Visual Pathways / Q000196:embryology / Q000502:physiology