title: Effect of nasolacrimal duct obstruction on nasal mucociliary transport.
abstract: BACKGROUND
  Most patients with nasolacrimal duct obstruction have dry, crusty nasal mucosa. Mucociliary clearance is modulated by the amount and biochemical composition of nasal mucus. Nasolacrimal duct obstruction disturbs the drainage of tears into the nasal cavity.
  
  
  OBJECTIVE
  We examined the effect of nasolacrimal duct obstruction on the mucociliary transport of nasal mucosa, by comparing saccharine test results for epiphora patients versus healthy volunteers.
  
  
  METHODS
  Prospective, randomised, clinical trial.
  
  
  METHODS
  Eight patients with bilateral epiphora and 10 patients with unilateral epiphora were included in the study group. Complete nasolacrimal duct obstruction was demonstrated by studying irrigation of the nasolacrimal system, and by fluorescein dye study. The control group comprised 20 healthy volunteers. Mucociliary transport was assessed by the saccharine test in both the study and control groups. The saccharine transit times of 26 impaired nasal cavities were compared with those of 20 healthy nasal cavities of controls. Also, the saccharine transit times of the healthy nasal cavities of the 10 patients with unilateral epiphora were compared with those of their diseased sides, and also with those of healthy volunteers.
  
  
  RESULTS
  The saccharine transit times of the epiphora patients were statistically significantly greater than those of the control group. Also, there was a statistically significant difference in saccharine transit times, comparing the healthy and impaired nasal cavities of patients with unilateral epiphora.
  
  
  CONCLUSIONS
  Nasolacrimal duct obstruction has a negative effect on nasal mucociliary clearance. This may be related to changes in the amount and biochemical composition of nasal mucus.
authors.affiliation: Otorhinolaryngology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey. drbnaib@yahoo.com
authors.forename: B
authors.initials: B
authors.lastname: Naiboglu
authors.forename: I
authors.initials: I
authors.lastname: Deveci
authors.forename: C
authors.initials: C
authors.lastname: Kalaycik
authors.forename: A
authors.initials: A
authors.lastname: Daylan
authors.forename: T E
authors.initials: TE
authors.lastname: Habesoglu
authors.forename: S Z
authors.initials: SZ
authors.lastname: Toros
authors.forename: S E
authors.initials: SE
authors.lastname: Deveci
authors.forename: E
authors.initials: E
authors.lastname: Egeli
mesh_terms: D000328:Adult; D005260:Female; D019793:Fluorescein; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000502:physiology*; D011446:Prospective Studies; D012439:Saccharin; D013997:Time Factors
chemical_list: D012439:Saccharin; D019793:Fluorescein