Potentiation of the stimulatory effect of erythropoietin on erythropoiesis by antiserotonin drug during cytostatic myelosuppression.
Combined stimulatory effect of antiserotonin drug and erythropoietin on the bone marrow erythropoiesis was studied under conditions of cytostatic myelosuppression. The stimulatory effect of erythropoietin on regeneration of the hemopoietic erythroid stem increased, if serotonin mediation in the CNS was disordered before induction of cytostatic myelosuppression. The stimulatory effect of a combination of cyproheptadine and epocrine (experimental group) significantly surpassed that of cyproheptadine and epocrine monotherapies. The increase in the content of erythroid elements in the blood system of experimental animals was due to recovery of the structural and functional integrity of the hemopoietic tissue (at the expense of reduction of the suppressive effect of CNS serotonin on the formation of erythroid hemopoietic islets) and simultaneous stimulation of division and maturation of erythroid precursors with epocrine.
Goldberg
E D
ED
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia.
Dygai
A M
AM
Skurikhin
E G
EG
Pershina
O V
OV
Minakova
M Yu
MY
Ermakova
N N
NN
Firsova
T V
TV
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D003533:Cyproheptadine / Q000494:pharmacology*; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000494:pharmacology*; D005260:Female; D005472:Fluorouracil / Q000633:toxicity*; D007166:Immunosuppressive Agents / Q000633:toxicity*; D051379:Mice; D008808:Mice, Inbred CBA; D012702:Serotonin Antagonists / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D012702:Serotonin Antagonists; D004921:Erythropoietin; D003533:Cyproheptadine; D005472:Fluorouracil