title: The effect of pre-emptive use of minimal dose fentanyl on fentanyl-induced coughing.
abstract: We performed a randomised, double-blind study to evaluate the effect of the pre-emptive use of minimal dose intravenous fentanyl (25 microg) on the incidence of cough caused by a larger bolus of intravenous fentanyl. Six hundred patients were randomly assigned to one of three groups to receive either 0.5 ml saline 0.9% 1 min before administration of fentanyl 150 microg (3 ml), or pre-emptive fentanyl 25 microg (0.5 ml) 1 min before administration of fentanyl 125 microg or 150 microg. The incidence of fentanyl-induced cough was significantly lower in both pre-emptive groups (7 (3.5%) for 125 microgfentanyl and 15 (7.5%) for 150 microg fentanyl) than in the saline group (37 (18.5%); p = 0.001). We conclude that pre-emptive use of fentanyl 25 microg, administered 1 min before bolus injection of fentanyl (125 or 150 microg), can effectively suppress fentanyl-induced cough.
authors.affiliation: Department of Anesthesiology, E-DA Hospital, Kaohsiung County, Taiwan.
authors.forename: K-C
authors.initials: KC
authors.lastname: Hung
authors.forename: C-W
authors.initials: CW
authors.lastname: Chen
authors.forename: V C-H
authors.initials: VC
authors.lastname: Lin
authors.forename: H-C
authors.initials: HC
authors.lastname: Weng
authors.forename: S-W
authors.initials: SW
authors.lastname: Hsieh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D001794:Blood Pressure / Q000187:drug effects; D003371:Cough / Q000139:chemically induced / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000009:adverse effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D007431:Intraoperative Complications / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D018686:Anesthetics, Intravenous; D005283:Fentanyl