title: The effect of prostaglandin analogues on central corneal thickness of patients with chronic open-angle glaucoma: a 2-year study on 129 eyes.
abstract: OBJECTIVE
  To evaluate the effect of prostaglandin analogues on the central corneal thickness (CCT) of patients with chronic open-angle glaucoma (COAG).
  
  
  METHODS
  One hundred and twenty-nine eyes were included in this study. Of these, 108 were treated with prostaglandin analogues (latanoprost, travoprost and bimatoprost), while 21 eyes treated with β-blockers were used as controls. CCT was measured before treatment and at 3-month intervals.
  
  
  RESULTS
  A slight but significant increase in CCT was recorded in the bimatoprost and latanoprost groups. Treatment with bimatoprost produced a constant increase (1.85-8.83 μm) in CCT at all time-points of the study. The CCT rise found in the latanoprost group was significant for the first year. Treatment with travoprost did not affect CCT.
  
  
  CONCLUSIONS
  The possibility of corneal thickening under prolonged, local prostaglandin treatment should be investigated further. However, in clinical practice, CCT changes may sometimes influence intraocular pressure measurements significantly.
authors.affiliation: Ophthalmology Department, Thriassio General Hospital, Athens, Greece. mbf90@otenet.gr
authors.forename: Maria
authors.initials: M
authors.lastname: Bafa
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Georgopoulos
authors.forename: Constantinos
authors.initials: C
authors.lastname: Mihas
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Stavrakas
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Papaconstantinou
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vergados
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000368:Aged; D000577:Amides / Q000008:administration & dosage / Q000009:adverse effects; D000069580:Bimatoprost; D003008:Cloprostenol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D003315:Cornea / Q000000981:diagnostic imaging* / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage* / Q000009:adverse effects; D011465:Prostaglandins, Synthetic / Q000008:administration & dosage* / Q000009:adverse effects; D000069557:Travoprost; D014463:Ultrasonography
chemical_list: D000319:Adrenergic beta-Antagonists; D000577:Amides; D011461:Prostaglandins F, Synthetic; D011465:Prostaglandins, Synthetic; D003008:Cloprostenol; D000077338:Latanoprost; D000069580:Bimatoprost; D000069557:Travoprost