Expression of markers of regulatory CD4+CD25+foxp3+ cells in atherosclerotic plaques of human coronary arteries.
The content of marker foxp3 of regulatory T cells and chemokines in atherosclerotic plaques of human coronary arteries was measured by the polymerase chain reaction. In vitro migration of regulatory CD4(+)CD25(+)foxp3(+) cells in the CD4(+) lymphocyte population from healthy donors was studied after treatment with chemokines I-309, IP-10, and SDF-1. mRNA for the factor foxp3 and chemokines SDF-1, I-309, and MIP-1beta were found in the majority of samples from atherosclerotic plaques. SDF-1 induced maximum migratory response of CD4(+)CD25(+)foxp3(+) cells.
Sokolov
V O
VO
Russian Cardiology Research-and-Production Complex, Russian Medical Technologies, Moscow, Russia. wsert@mail.ru
Krasnikova
T L
TL
Prokofieva
L V
LV
Kukhtina
N B
NB
Arefieva
T I
TI
D050197:Atherosclerosis / Q000276:immunology* / Q000378:metabolism; D015704:CD4 Antigens / Q000276:immunology*; D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D054402:Chemokine CCL1 / Q000378:metabolism; D054407:Chemokine CCL4 / Q000378:metabolism; D054357:Chemokine CXCL10 / Q000378:metabolism; D054377:Chemokine CXCL12 / Q000378:metabolism; D003331:Coronary Vessels / Q000378:metabolism*; D051858:Forkhead Transcription Factors / Q000276:immunology* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology*; D016133:Polymerase Chain Reaction; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology*
D015704:CD4 Antigens; D054402:Chemokine CCL1; D054407:Chemokine CCL4; D054357:Chemokine CXCL10; D054377:Chemokine CXCL12; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D053645:Interleukin-2 Receptor alpha Subunit