Inflammation in chronic rhinosinusitis and nasal polyposis.
Inflammation is a defining characteristic of chronic rhinosinusitis and nasal polyposis. Research had traditionally focused on the role of eosinophils in the pathogenic mechanisms, but recently more attention has been given to neutrophils and to different T-lymphocyte subtypes. This article summarizes current understanding, and discusses opportunities and potential pitfalls of inflammation-related research.
van Drunen
Cornelis M
CM
Department of Otorhinolaryngology, Academic Medical Center, Room L3-104-2, PO box 22700, 1100 DE Amsterdam, The Netherlands. c.m.vandrunen@amc.uva.nl
Reinartz
Susanne
S
Wigman
Jochem
J
Fokkens
Wytske J
WJ
D002908:Chronic Disease; D004804:Eosinophils / Q000276:immunology*; D006801:Humans; D056747:Immunomodulation; D007249:Inflammation / Q000276:immunology; D009298:Nasal Polyps / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*; D012220:Rhinitis / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D012852:Sinusitis / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D016176:T-Lymphocyte Subsets / Q000276:immunology*