title: Long-term outcomes in pediatric liver transplantation.
abstract: 1. Critical clinical outcomes for pediatric liver transplantation (LT) recipients include (1) patient and graft survival, (2) complications (immune and nonimmune) of chronic immunosuppressive medications, and (3) long-term graft function. 2. Recurrence of malignancy, sepsis, and posttransplant lymphoproliferative disorder account for more than 65% of deaths occurring more than 1 year after LT. 3. Chronic rejection, late hepatic artery thrombosis, and biliary strictures account for 70% of graft loss occurring more than 1 year after LT. 4. Late histological changes in the allograft are emerging as a common problem in patients more than 5 years after LT. The pathogenesis of these findings and the impact on graft survival remain to be determined.
authors.affiliation: Cincinnati Children's Hospital, Cincinnati, OH 45229-3039, USA. john.bucuvalas@cchmc.org
authors.forename: John
authors.initials: J
authors.lastname: Bucuvalas
mesh_terms: D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods / Q000401:mortality; D010349:Patient Compliance; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology; D011788:Quality of Life; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents