Observations on the Uganda I strain of Plasmodium malariae and Plasmodium brasilianum in Aotus and Saimiri monkeys and Anopheles mosquitoes.
Splenectomized Aotus lemurinus griseimembra, A. azarae boliviensis, A. nancymaae, A. vociferans, and Saimiri boliviensis monkeys were infected with the Uganda I/CDC strain of Plasmodium malariae. The maximum parasite counts were lower if the animals had been previously infected with Plasmodium vivax. Mosquito infection was concentrated in the 12 days following the rise in count above 1,000/microl. Mosquito infection and parasite counts were highest with A. l. griseimembra. Anopheles freeborni was more readily infected than An. gambiae, which was more readily infected than An. stephensi. Parasite counts and mosquito infection with P. brasilianum were much higher in S. boliviensis monkeys than with the Uganda I strain of P. malariae in this host, suggesting marked differences between the host-parasite-vector relationships and indicating that P. brasilianum in S. boliviensis monkeys may be a better reflection of the relationship of P. malariae in the human host.
Collins
William E
WE
Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA. wec1@cdc.gov
Sullivan
Jo Ann S
JA
Nace
Douglas
D
Williams
Tyrone
T
Williams
Allison
A
Barnwell
John W
JW
D000818:Animals; D000852:Anopheles / Q000469:parasitology*; D016645:Aotidae / Q000276:immunology / Q000469:parasitology*; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000469:parasitology; D006790:Host-Parasite Interactions; D007303:Insect Vectors / Q000469:parasitology*; D008288:Malaria / Q000276:immunology / Q000469:parasitology; D018512:Parasitemia / Q000276:immunology / Q000469:parasitology; D010961:Plasmodium / Q000145:classification / Q000276:immunology / Q000502:physiology*; D010965:Plasmodium malariae / Q000145:classification / Q000276:immunology / Q000502:physiology; D012044:Regression Analysis; D012453:Saimiri / Q000276:immunology / Q000469:parasitology*; D013156:Splenectomy