title: Pretreatment with l-histidine produces a shift from methamphetamine-induced stereotypical biting to persistent locomotion in mice.
abstract: The administration of methamphetamine (METH; 10mg/kg, i.p.) to male ICR mice induced bizarre behaviors including persistent locomotion and stereotypical behaviors, which were classified into four categories: stereotypical head-bobbing, circling, sniffing, and biting. Pretreatment with l-histidine (750 mg/kg, i.p.) significantly decreased the stereotypical biting induced by METH and significantly increased persistent locomotion. This effect of l-histidine on behavior was completely abolished by simultaneous administration of pyrilamine or ketotifen (brain-penetrating histamine H(1) receptor antagonists; 10mg/kg each, i.p.), but not by the administration of fexofenadine (a non-sedating histamine H(1) receptor antagonist that does not cross the blood-brain barrier; 20mg/kg), zolantidine (a brain-penetrating histamine H(2) receptor antagonist; 10mg/kg), thioperamide, or clobenpropit (brain-penetrating histamine H(3) receptor antagonists; 10mg/kg each). The histamine content of the hypothalamus was significantly increased by l-histidine treatment. These data suggest that l-histidine modifies the effects of METH through central histamine H(1) receptors.
authors.affiliation: Department of Pharmacology, Hyogo College of Medicine, Hyogo 663-8501, Japan. kitanaka-hyg@umin.net
authors.forename: Junichi
authors.initials: J
authors.lastname: Kitanaka
authors.forename: Nobue
authors.initials: N
authors.lastname: Kitanaka
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Tatsuta
authors.forename: Akio
authors.initials: A
authors.lastname: Miyoshi
authors.forename: Atena
authors.initials: A
authors.lastname: Koumoto
authors.forename: Koh-Ichi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Nishiyama
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Morita
authors.forename: Motohiko
authors.initials: M
authors.lastname: Takemura
mesh_terms: D000818:Animals; D001733:Bites and Stings; D006632:Histamine / Q000378:metabolism; D006639:Histidine / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D008761:Methylhistamines / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D013239:Stereotyped Behavior / Q000187:drug effects*
chemical_list: D008761:Methylhistamines; D008694:Methamphetamine; D006639:Histidine; D006632:Histamine; C048140:N-methylhistamine