A mechanistic study on gefitinib-induced apoptosis reveals a new link between EGFR and hTERT in breast cancers.
Lee
Chang Hoon
CH
National Cancer Center Institute, Division of Cancer Biology, Gyeonggi-do, Korea. metastasis@ncc.re.kr
D017209:Apoptosis / Q000187:drug effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005260:Female; D000077156:Gefitinib; D006801:Humans; D011799:Quinazolines / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000378:metabolism*
D011799:Quinazolines; C512478:EGFR protein, human; D066246:ErbB Receptors; C509186:TERT protein, human; D019098:Telomerase; D000077156:Gefitinib