Ankyrin regulates KATP channel membrane trafficking and gating in excitable cells.
K(ATP) channels play critical roles in many cellular functions by coupling cell metabolic status to electrical activity. First discovered in cardiomyocytes,(1) K(ATP) channels (comprised of Kir6.x and SUR subunits) have since been found in many other tissues, including pancreatic beta cells, skeletal muscle, smooth muscle, brain, pituitary and kidney. By linking cellular metabolic state with membrane potential, K(ATP) channels are able to regulate a number of cellular functions such as hormone secretion, vascular tone and excitability. Specifically, a reduction in metabolism causes a decrease in the ATP:ADP ratio, opening of K(ATP) channels, K(+) efflux, membrane hyperpolarization, and suppression of electrical activity. Conversely, increased cellular metabolism causes an increase in the ATP:ADP ratio that leads to closure of the K(ATP) channel, membrane depolarization, and stimulation of cell electrical activity.
Kline
Crystal F
CF
Department of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Hund
Thomas J
TJ
Mohler
Peter J
PJ
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D017487:Ankyrins / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D015640:Ion Channel Gating; D054086:KATP Channels / Q000235:genetics / Q000378:metabolism*; D008564:Membrane Potentials; D009154:Mutation; D010641:Phenotype; D011188:Potassium / Q000378:metabolism*; D021381:Protein Transport
D017487:Ankyrins; D054086:KATP Channels; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D011188:Potassium