Calcium signals: STIM dynamics mediate spatially unique oscillations.
Receptor-induced Ca(2+) oscillations provide 'digitized' signals that confer precise activation of downstream targets. New studies reveal that STIM proteins - sensors of endoplasmic reticulum Ca(2+) levels - cyclically translocate during oscillations, transiently coupling to activate cell-surface Ca(2+) entry channels, resulting in a spatially unique signal that selectively triggers immediate-early gene expression.
Mancarella
Salvatore
S
Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Wang
Youjun
Y
Gill
Donald L
DL
D015220:Calcium Channels / Q000502:physiology; D020013:Calcium Signaling; D015815:Cell Adhesion Molecules / Q000378:metabolism / Q000502:physiology*; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology*; D009363:Neoplasm Proteins / Q000378:metabolism / Q000502:physiology*; D000071737:Stromal Interaction Molecule 1; D000071738:Stromal Interaction Molecule 2
D015220:Calcium Channels; D015815:Cell Adhesion Molecules; D008565:Membrane Proteins; D009363:Neoplasm Proteins; C103530:STIM1 protein, human; C513279:STIM2 protein, human; D000071737:Stromal Interaction Molecule 1; D000071738:Stromal Interaction Molecule 2