title: Diffuse neurosarcoidosis involving only the leptomeninges of the brainstem and spinal cord.
abstract: MRI findings of sarcoidosis are usually intraparenchymal granuloma with leptomeningeal lesions. This appearance is dependent upon leptomeningeal lesions subsequently infiltrating to parenchyma. We describe a 52-year-old man with slowly progressive paresthesias and weakness in his legs. MRI showed diffuse leptomeningeal lesions throughout the brainstem and spinal cord without intraparenchymal lesions. A diagnosis of sarcoidosis was confirmed by cervical lymph node biopsy which detected noncaseating granuloma. Only leptomeningeal lesions throughout the brainstem and spinal cord could be observed in sarcoidosis.
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Makino
authors.forename: Shoichi
authors.initials: S
authors.lastname: Ito
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mori
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwabara
mesh_terms: D001706:Biopsy; D001933:Brain Stem / Q000473:pathology*; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000473:pathology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D012507:Sarcoidosis / Q000188:drug therapy / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone; D008775:Methylprednisolone