title: A case-control study on risk factors of osteoporosisin patients with Crohn's disease.
abstract: BACKGROUND
  Osteoporosis has been frequently reported in patients with inflammatory bowel diseases, especially Crohn's disease.
  
  
  METHODS
  All consecutive Crohn's disease patients who attended the GI Clinics at Shariati Hospital, Tehran, Iran, from 2004 to 2007 were evaluated. A BMD-DEXA assessment was performed for all patients. Among those patients diagnosed with osteoporosis (T score <or= -2.5 SD), 30 patients were chosen as study cases. Of those who were not diagnosed with osteoporosis, 85 were chosen as the control group. A thorough patient history including: age, sex, body mass index, cumulative corticosteroid dose, previous fracture, history of bowel resection, site and duration of disease, smoking and consumption of calcium and vitamin D, was taken from all patients through a face-to-face interview. Independent sample Student's t-test, Chi-square, and logistic regression analyses were used for data analysis.
  
  
  RESULTS
  In this study, a multivariable modeling technique revealed a higher osteoporosis risk in those who had a lower body mass index, previous fractures and longer disease duration. A cumulative corticosteroid dose of 10 - 35 g provided the highest osteoporosis risk. Age, sex, bowel resection, site of disease, smoking and consumption of calcium and vitamin D did not show any relationship with osteoporosis.
  
  
  CONCLUSIONS
  The highest osteoporosis risk was seen in patients with a cumulative 10 - 35 g corticosteroid dose and could be due to both steroid inefficiency in reducing Crohn's disease inflammation as well as the cumulative drug dose and it's adverse effect on patients.
authors.affiliation: Digestive Disease Research Center, Shariati Hospital, Medical Sciences/ University of Tehran, Iran. vahedi@ams.ac.ir
authors.forename: Homayoun
authors.initials: H
authors.lastname: Vahedi
authors.forename: Shabnam
authors.initials: S
authors.lastname: Momtahen
authors.forename: Golrokh
authors.initials: G
authors.lastname: Olfati
authors.forename: Azadeh
authors.initials: A
authors.lastname: Abtahi
authors.forename: Sarah
authors.initials: S
authors.lastname: Hosseini
authors.forename: Amir-Sadreddin
authors.initials: AS
authors.lastname: Kazzazi
authors.forename: Hooman
authors.initials: H
authors.lastname: Khademi
authors.forename: Shahrooz
authors.initials: S
authors.lastname: Rashtak
authors.forename: Reza
authors.initials: R
authors.lastname: Khaleghnejad
authors.forename: Tahmineh
authors.initials: T
authors.lastname: Tabrizian
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Hamidi
authors.forename: Mehdi
authors.initials: M
authors.lastname: Nouraie
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Malekzadeh
authors.forename: Shahin
authors.initials: S
authors.lastname: Merat
authors.forename: Siavosh
authors.initials: S
authors.lastname: Nasseri-Moghaddam
authors.forename: Rasoul
authors.initials: R
authors.lastname: Sotoudehmanesh
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density; D016022:Case-Control Studies; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010024:Osteoporosis / Q000209:etiology*; D012307:Risk Factors