title: A lichen substance as an antiproliferative compound against HL-60 human leukemia cells: 16-O-acetyl-leucotylic acid isolated from Myelochroa aurulenta.
abstract: The lichen substance, 16-O-acetyl-leucotylic acid (1), was isolated from an acetone extract of Myelochroa aurulenta and found to exhibit antiproliferative activity against HL-60 human leukemia cells. This is the first report on its anti-leukemia activity (EC(50)=21 microM) which is greater than that of leucotylic acid (2) and the structurally related anti-tumor agent, betulinic acid (4).
authors.affiliation: Department of Biological Resource Sciences, Akita Prefectural University, Akita, Japan. tkwn@akita-pu.ac.jp
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Tokiwano
authors.forename: Hikari
authors.initials: H
authors.lastname: Satoh
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Obara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirota
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yoshizawa
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Yamamoto
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D008011:Lichens / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C547204:16-O-acetyl-leucotylic acid; D000970:Antineoplastic Agents; D014315:Triterpenes