title: Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs.
abstract: Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human cancer cell lines.
authors.affiliation: Department of Organic Chemistry, University of Vienna, Währinger Strasse 38, 1090 Vienna, Austria.
authors.forename: Rita
authors.initials: R
authors.lastname: Fürst
authors.forename: István
authors.initials: I
authors.lastname: Zupkó
authors.forename: Agnes
authors.initials: A
authors.lastname: Berényi
authors.forename: Gerhard F
authors.initials: GF
authors.lastname: Ecker
authors.forename: Uwe
authors.initials: U
authors.lastname: Rinner
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D003521:Cyclopropanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D050257:Tubulin Modulators / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D003521:Cyclopropanes; D013267:Stilbenes; D050257:Tubulin Modulators; C058728:fosbretabulin