MAP-ping unconventional protein-DNA interactions.
Control of gene expression depends on a myriad of protein-DNA interactions, and the number of proteins involved just got larger. In this issue, Hu et al. (2009) identify hundreds of human proteins that bind to DNA, including many surprises such as the protein kinase ERK2 (MAPK1) that now appears to control gene expression directly.
Dioum
Elhadji M
EM
Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Wauson
Eric M
EM
Cobb
Melanie H
MH
D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism*
D004268:DNA-Binding Proteins; D004247:DNA; D019950:Mitogen-Activated Protein Kinase 1