title: Multiple convergence in polyketide biosynthesis: a third folding mode to the anthraquinone chrysophanol.
abstract: The polyketide chrysophanol is shown to be formed, in an organism-specific way, by a third folding mode, involving a remarkable cyclization of a bicyclic diketo precursor, thus establishing the first example of multiple convergence in polyketide biosynthesis.
authors.affiliation: Institute of Organic Chemistry, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany. bringman@chemie.uni-wuerzburg.de
authors.forename: Gerhard
authors.initials: G
authors.lastname: Bringmann
authors.forename: Tobias A M
authors.initials: TA
authors.lastname: Gulder
authors.forename: Andreas
authors.initials: A
authors.lastname: Hamm
authors.forename: Michael
authors.initials: M
authors.lastname: Goodfellow
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
mesh_terms: D000880:Anthraquinones; D003500:Cyclization; D056890:Eukaryota; D018942:Macrolides; D053858:Metabolic Networks and Pathways; D048630:Polyketide Synthases / Q000378:metabolism; D011387:Prokaryotic Cells
chemical_list: D000880:Anthraquinones; D018942:Macrolides; D048630:Polyketide Synthases; C027113:chrysophanic acid