ON THE RATE OF REACTION BETWEEN ENZYME AND SUBSTRATE.
1. An equation of the form: See PDF for Equation in which v(t) is the time of flow of the mixture, v(w) the time of flow for water, v(f) the time of flow of the mixture when proteolysis is complete, v(o) the time of flow at the beginning of the experiment, t the time of observation, and r a constant, has been found to describe accurately the course of change of viscosity in a mixture of gelatin and pancreatin. 2. An equation of the same general form has been found to apply similarly to the reaction between other enzymes and other substrates. 3. The equation may be derived theoretically from assuming a bimolecular reaction between enzyme and substrate obeying the mass action law.
Berkson
J
J
Department of Pediatrics of The Johns Hopkins University School of Medicine, Baltimore.
Flexner
L B
LB