title: Rapid HIV diagnostic test in undocumented pregnant women applied at an inner-city teaching hospital.
abstract: A significant number of Brazilian gestational-age women are still not tested for HIV, representing a high risk of transmission to their newborns. The current study sought to identify the number of pregnant women with no previous testing or undocumented for HIV referred to the Gynecology and Obstetrics Department of a Regional Teaching Hospital and included diagnosis of HIV infection determined by a rapid test and perinatal transmission in pregnancy. Medical records of all pregnant women admitted to hospital from January 2001 to December 2005 were reviewed. Pregnant women without HIV results were submitted to a rapid HIV test. Those who tested positive were further tested by ELISA and confirmed by indirect immunofluorescence assay (IIA) or Western blot (WB). The viral load from babies born to HIV-infected mothers was assessed by bDNA. Of the 16,424 pregnant women analyzed (6.6%), 1,089 were undocumented for HIV. Eleven women were positive in rapid testing and 10 were confirmed by ELISA, IIA or WB, with 0.9% seropositivity. Mother/infant pairs received zidovudine monotherapy prophylaxis and infant viral load was lower than 50 copies/mL. A higher number of pregnant women previously tested for HIV during antenatal care was verified, compared to that obtained nationwide.
authors.affiliation: Departamento de Imunologia e Pós-Graduação e Pesquisa, Universidade do Oeste Paulista, Presidente Prudente, SP, Brasil. luiz@unoeste.br
authors.forename: Luiz Euribel
authors.initials: LE
authors.lastname: Prestes-Carneiro
authors.forename: Nadia Araújo
authors.initials: NA
authors.lastname: Miguel
authors.forename: Eloah Lopes
authors.initials: EL
authors.lastname: Ascêncio
authors.forename: Marisa
authors.initials: M
authors.lastname: Amâncio
authors.forename: Vera Lúcia Maria
authors.initials: VL
authors.lastname: Alcântara
authors.forename: José Alexandre
authors.initials: JA
authors.lastname: Portelinha-Filho
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D015153:Blotting, Western; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D015658:HIV Infections / Q000175:diagnosis* / Q000517:prevention & control / Q000635:transmission; D006784:Hospitals, Teaching; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000517:prevention & control; D011933:Reagent Kits, Diagnostic; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D011933:Reagent Kits, Diagnostic; D015215:Zidovudine