A comparative study between corresponding structural geometric variables using 2 commonly implemented hip structural analysis algorithms applied to dual-energy X-ray absorptiometry images.
Hip structural analysis (HSA) has been developed over 20 yr, applied extensively in research, and has demonstrated useful outcomes associating bone structural geometry with bone fragility (research-HSA or r-HSA). In 2007, Hologic Inc. (Bedford, MA) incorporated HSA with some modifications as an option for Hologic dual-energy X-ray absorptiometry (DXA) scanners (clinical HSA or c-HSA). This brought HSA from the research environment into the clinical environment. This article reports a comparison of r-HSA and c-HSA implementations using DXA scans from a group of 191 females. Bland-Altman plots at the narrow-neck (NN) HSA region indicated higher r-HSA areal bone mineral density (mean difference: 0.27 g/cm(2); 21.7% [of mean]); cross-sectional area (0.63 cm(2); 18.7%); cross-sectional moment of inertia (0.26 cm(4); 11.1%), and section modulus (0.22 cm(3); 14.5%) compared with c-HSA. The converse was observed for NN subperiosteal width (-0.09 cm; 3.1%). High linear correlations (r(2) > 0.81) were found between r-HSA and c-HSA NN structural geometric outcomes, with the exception of neck shaft angle (r(2) > 0.47). As differences were significant (p < 0.001), slopes and intercepts are provided to enable linear transformations from r-HSA to corresponding c-HSA structural geometric data.
Khoo
Benjamin C C
BC
Department of Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Wilson
Scott G
SG
Worth
Graeme K
GK
Perks
Ursula
U
Qweitin
Emad
E
Spector
Timothy D
TD
Price
Roger I
RI
D015502:Absorptiometry, Photon / Q000379:methods*; D000328:Adult; D000465:Algorithms; D015519:Bone Density / Q000502:physiology*; D001330:Electronic Data Processing / Q000379:methods*; D005260:Female; D006801:Humans; D010024:Osteoporosis / Q000175:diagnosis; D010384:Pelvic Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D015203:Reproducibility of Results; D012307:Risk Factors