Wavelet and fractal analysis of rat brain activity in seizures evoked by camphor essential oil and 1,8-cineole.
We investigated the rat brain activity in acute seizures evoked by camphor essential oil or its main constituent 1,8-cineole by wavelet (primarily) and fractal analysis. Experiments were performed on anesthetized animals before and after intraperitoneal camphor oil or cineole administration. The properties of frequency bands in pre-ictal, ictal and inter-ictal stages have been determined by wavelet analysis. The domination of delta frequency band was confirmed in obtained brain activities, which participate with approximately 45% of mean relative wavelet energy (MRWE) in control signals and arise up to approximately 76% MRWE in energy spectrum during the ictal stage (after drug administration). Other frequency bands decreased during ictal stage and arised in inter-ictal stage. There was a dosedependent response of cineole effect: increase in cineole concentration leaded to the higher values of relative wavelet energy (RWE) of delta frequency band while there were slight changes of the mean fractal dimension (FD) values as a measure of system complexity.
Culić
Milka
M
Institute for Biological Research "Sinisa Stanković", University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia. milkacul@ibiss.bg.ac.yu
Keković
Goran
G
Grbić
Gordana
G
Martać
Ljiljana
L
Soković
Marina
M
Podgorac
Jelena
J
Sekulić
Slobodan
S
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D002164:Camphor / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D003511:Cyclohexanols / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D055724:Electrophysiological Phenomena / Q000187:drug effects; D000077591:Eucalyptol; D017709:Fractals; D008297:Male; D039821:Monoterpenes / Q000494:pharmacology*; D009822:Oils, Volatile / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology*
D003511:Cyclohexanols; D039821:Monoterpenes; D009822:Oils, Volatile; D002164:Camphor; D000077591:Eucalyptol