Arm movement maps evoked by cortical magnetic stimulation in a robotic environment.
Many neurological diseases result in a severe inability to reach for which there is no proven therapy. Promising new interventions to address reaching rehabilitation using robotic training devices are currently under investigation in clinical trials but the neural mechanisms that underlie these interventions are not understood. Transcranial magnetic stimulation (TMS) may be used to probe such mechanisms quickly and non-invasively, by mapping muscle and movement representations in the primary motor cortex (M1). Here we investigate movement maps in healthy young subjects at rest using TMS in the robotic environment, with the goal of determining the range of TMS accessible movements, as a starting point for the study of cortical plasticity in combination with robotic therapy. We systematically stimulated the left motor cortex of 14 normal volunteers while the right hand and forearm rested in the cradle of a two degree-of-freedom planar rehabilitation robot (IMT). Maps were created by applying 10 stimuli at each of nine locations (3x3 cm(2) grid) centered on the M1 movement hotspot for each subject, defined as the stimulation location that elicited robot cradle movements of the greatest distance. TMS-evoked movement kinematics were measured by the robotic encoders and ranged in magnitude from 0 to 3 cm. Movement maps varied by subject and by location within a subject. However, movements were very consistent within a single stimulation location for a given subject. Movement vectors remained relatively constant (limited to <90 degrees section of the planar field) within some subjects across the entire map, while others covered a wider range of directions. This may be due to individual differences in cortical physiology or anatomy, resulting in a practical limit to the areas that are TMS-accessible. This study provides a baseline inventory of possible TMS-evoked arm movements in the robotic reaching trainer, and thus may provide a real-time, non-invasive platform for neurophysiology based evaluation and therapy in motor rehabilitation settings.
Jones-Lush
L M
LM
Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD, USA.
Judkins
T N
TN
Wittenberg
G F
GF
D000328:Adult; D000704:Analysis of Variance; D001132:Arm / Q000502:physiology*; D001696:Biomechanical Phenomena; D004576:Electromyography; D019054:Evoked Potentials, Motor; D007839:Functional Laterality; D006801:Humans; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D018482:Muscle, Skeletal; D009473:Neuronal Plasticity; D012044:Regression Analysis; D012371:Robotics / Q000379:methods*; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D055815:Young Adult