Acute phase protein changes in calves during an outbreak of respiratory disease caused by bovine respiratory syncytial virus.
Bovine acute phase proteins (APPs), lipopolysaccharide binding protein (LBP), serum amyloid A (SAA), haptoglobin (Hp) and alpha(1)-acid glycoprotein (AGP) were evaluated as inflammatory markers during an outbreak of bovine respiratory disease (BRD) caused by bovine respiratory syncytial virus (BRSV). Calves (n = 10) presented mild to moderate signs of respiratory disease. Secondary bacterial infections, Pasteurella multocida and Mycoplasma dispar as major species, were detected in tracheobronchial lavage samples. Concentrations of SAA and LBP increased at week 1 had the highest values at week 3 and decreased at week 4 of outbreak. Some calves had high Hp concentrations at week 3, but AGP concentrations did not rise during respiratory disease. Higher SAA, LBP and Hp concentrations at a later stage of BRD (week 3) were associated with the low BRSV-specific IgG(1) production, suggesting that these calves had enhanced inflammatory response to the secondary bacterial infection. In conclusion, APPs (especially SAA and LBP) are sensitive markers of respiratory infection, and they may be useful to explore host response to the respiratory infections in clinical research.
Orro
Toomas
T
Department of Animal Health and Environment, Estonian University of Life Sciences, Tartu, Estonia. toomas.orro@emu.ee
Pohjanvirta
Tarja
T
Rikula
Ulla
U
Huovilainen
Anita
A
Alasuutari
Sakari
S
Sihvonen
Liisa
L
Pelkonen
Sinikka
S
Soveri
Timo
T
D000209:Acute-Phase Proteins / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology / Q000276:immunology*; D004196:Disease Outbreaks; D005260:Female; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*; D018112:Respiratory Syncytial Virus, Bovine / Q000502:physiology; D013997:Time Factors
D000209:Acute-Phase Proteins; D000914:Antibodies, Viral; D007074:Immunoglobulin G