Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples.
Previous studies have found haplotypic association of HTR4 variants and schizophrenia. Examining case-control pairs, G-G of rs7713886 was associated with schizophrenia risk. The A-A-G-G-G-A-A rs9325104-rs1422636-rs7715569-rs6873382-rs7711800-rs10078551-rs2068190 haplotype was overrepresented in the schizophrenia cases. The associations were no longer significant after corrections for multiple comparisons. No association was found in the family sample.
Hirata
Yuko
Y
Neurogenetics Section, CAMH, Toronto, ON, Canada.
Souza
Renan P
RP
Lieberman
Jeffrey A
JA
Meltzer
Herbert Y
HY
Kennedy
James L
JL
D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D044422:Receptors, Serotonin, 5-HT4 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
D044422:Receptors, Serotonin, 5-HT4