title: 'Not knowing something is normally a milestone on the way to knowledge'. An interview with Joan M. Braganza, DSc, FRCP, FRCPath, Reader Emeritus, University of Manchester, UK.
abstract: Dr. Joan Braganza, a world expert in the field of chronic pancreatitis, proposed a new template for its pathogenesis based on the role of free radical pathology, in particular the heightened but unmitigated oxidative detoxification reactions via cytochromes P450. Dr. Braganza has gone on to show how pancreatic damage in cystic fibrosis, acute pancreatitis and pancreatic cancer fit into the scheme, paving the way for new treatment modalities. In this interview, Dr. Braganza shares her life experience as an investigator and provides a perspective for young researchers entering the field of pancreatology.
authors.affiliation: Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, Minn. 55905, USA. fernandezzapico.martin@mayo.edu
authors.forename: Joan M
authors.initials: JM
authors.lastname: Braganza
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use; D003550:Cystic Fibrosis / Q000150:complications / Q000178:diet therapy / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000209:etiology / Q000378:metabolism; D050500:Pancreatitis, Chronic / Q000178:diet therapy / Q000378:metabolism* / Q000473:pathology; D017382:Reactive Oxygen Species / Q000009:adverse effects / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D003577:Cytochrome P-450 Enzyme System