Oxygenated cembranoids from the cultured and wild-type soft corals Sinularia flexibilis.
Two new cembranoids, flexibilisolide A (1) and flexibilisin A (2), along with one known combranoid 5 have been isolated from the cultured soft coral Sinularia flexibilis. Furthermore, two new cembranoids, flexibilisolide B (3) and flexibilisin B (4), along with two known combranoids (5, 6), have been isolated from the wild-type soft coral S. flexibilis. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis and by comparison of NMR data with those of known compounds. The metabolites 5 and 6 have been shown to exhibit weak cytotoxic activity against MCF-7 cancer cell line.
Su
Jui-Hsin
JH
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Lin
Yu-Fang
YF
Lu
Yi
Y
Yeh
Hsiao-Chien
HC
Wang
Wei-Hsien
WH
Fan
Tung-Yung
TY
Sheu
Jyh-Horng
JH
D000818:Animals; D037421:Anthozoa / Q000737:chemistry* / Q000254:growth & development / Q000378:metabolism; D018929:Cell Culture Techniques / Q000379:methods*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
D004224:Diterpenes; C546131:flexibilisin A; C546133:flexibilisin B; C546132:flexibilisolide A; C546134:flexibilisolide B; D010100:Oxygen