title: Complementary image analysis of diffusion tensor imaging and 3-dimensional t1-weighted imaging: white matter analysis in amyotrophic lateral sclerosis.
abstract: BACKGROUND
  in order to obtain detailed information on disease-associated changes in the integrity of cerebral white matter (WM), complementary image analysis (CIA) was applied to patients with amyotrophic lateral sclerosis (ALS) and controls.
  
  
  METHODS
  both diffusion tensor imaging and T1-weighted 3-dimensional data were analyzed with respect to WM microstructure and T1 signal intensity alterations, respectively, in a sample of 19 ALS patients. Covariate information was added in the form of clinical parameters. All results were obtained in one common analysis software environment (Tensor Imaging and Fiber Tracking).
  
  
  RESULTS
  complementary analysis and display were performed for WM directionality and structure. Significant WM differences between ALS patients and controls were observed both in the motor system, that is, the bilateral corticospinal tracts, and in extramotor brain areas, in part correlating with clinical parameters. The performance of all analyses in one software environment enabled the synopsis of results obtained from various analyses.
  
  
  CONCLUSIONS
  within the application of CIA to a neurodegenerative disease for the whole brain-based analysis of WM alterations together with clinical characteristics, it could be demonstrated that ALS was associated with WM changes within and outside the motor system.
authors.affiliation: Department of Neurology, University of Ulm, Ulm, Germany. hans-peter.mueller@uni-ulm.de
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Müller
authors.forename: Dorothée
authors.initials: D
authors.lastname: Lulé
authors.forename: Alexander
authors.initials: A
authors.lastname: Unrath
authors.forename: Albert C
authors.initials: AC
authors.lastname: Ludolph
authors.forename: Axel
authors.initials: A
authors.lastname: Riecker
authors.forename: Jan
authors.initials: J
authors.lastname: Kassubek
mesh_terms: D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology*; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009483:Neuropsychological Tests