title: Thalidomide and bortezomib overcome the prognostic significance of proliferative index in multiple myeloma.
abstract: We analyzed proliferative index of myeloma plasmocytes (PC-PI) in acohort of 217 patients with multiple myeloma (MM) treated with conventional chemotherapy and biological agents, thalidomide and bortezomib. In the whole group was adifference between overall survival (OS) favoring patients with PC-PI ven after 40 months (median overall survival 25 vs 10months, p= 0.015), whereas in the group treated with thalidomide and bortezomib was no difference, with medians over 39 months. Even patients with low PC-PI profited from the treatment with novel drugs. Presented results suggest that the treatment of MM with novel agents overcomes the prognostic significance of PC-PI and should be used in all MM patients.
  
  
  BACKGROUND
  myeloma -prognostication -proliferative index -biological therapy.
authors.affiliation: Department of Internal Medicine III, University Hospital Olomouc, Czech Republic. abretina@email.cz
authors.forename: J
authors.initials: J
authors.lastname: Minarik
authors.forename: V
authors.initials: V
authors.lastname: Scudla
authors.forename: J
authors.initials: J
authors.lastname: Bacovsky
authors.forename: M
authors.initials: M
authors.lastname: Zemanova
authors.forename: T
authors.initials: T
authors.lastname: Pika
authors.forename: M
authors.initials: M
authors.lastname: Ordeltova
authors.forename: K
authors.initials: K
authors.lastname: Langova
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001897:Boronic Acids / Q000627:therapeutic use*; D000069286:Bortezomib; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology; D011379:Prognosis; D011719:Pyrazines / Q000627:therapeutic use*; D013792:Thalidomide / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D001897:Boronic Acids; D011719:Pyrazines; D013792:Thalidomide; D000069286:Bortezomib