Dissociation of local anti-inflammatory effect and systemic effects of mometasone furoate in mice.
Mometasone furoate (MF) is a topical glucocorticoid used for atopic dermatitis, allergic rhinitis, and bronchial asthma. To elucidate the usefulness of MF, the dissociation between local anti-inflammatory effects and systemic effects of MF was compared with that of beclomethasone 17,21-dipropionate (BDP). MF was more potent than BDP in croton oil-induced ear edema tests in mice. Oral systemic effects of MF were inversely lower than that of BDP on thymolysis, plasma corticosterone lowering, and suppression of body weight gain in mice. These results indicate that MF has a higher therapeutic index and superior clinical usefulness as a topical glucocorticoid compared to BDP.
Ogawa
Masami
M
Preclinical Research Department, Research & Development Division, Schering-Plough K.K., Osaka, Japan. masami.ogawa@spcorp.com
Sakonjo
Hiroshi
H
Kamei
Chiaki
C
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001507:Beclomethasone / Q000008:administration & dosage; D003345:Corticosterone / Q000097:blood; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D000068656:Mometasone Furoate; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D011244:Pregnadienediols / Q000008:administration & dosage*; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology; D015430:Weight Gain / Q000187:drug effects / Q000276:immunology
D000893:Anti-Inflammatory Agents; D011244:Pregnadienediols; D000068656:Mometasone Furoate; D001507:Beclomethasone; D003345:Corticosterone