title: Structural properties of pore-forming oligomers of alpha-synuclein.
abstract: Soluble oligomers are potent toxins in many neurodegenerative diseases, but little is known about the structure of soluble oligomers and their structure-toxicity relationship. Here we prepared on-pathway oligomers of the 140-residue protein alpha-synuclein, a key player in Parkinson's disease, at concentrations an order of magnitude higher than previously possible. The oligomers form ion channels with well-defined conductance states in a variety of membranes, and their beta-structure differs from that of amyloid fibrils of alpha-synuclein.
authors.affiliation: Department of NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
authors.forename: Hai-Young
authors.initials: HY
authors.lastname: Kim
authors.forename: Min-Kyu
authors.initials: MK
authors.lastname: Cho
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Kumar
authors.forename: Elke
authors.initials: E
authors.lastname: Maier
authors.forename: Carsten
authors.initials: C
authors.lastname: Siebenhaar
authors.forename: Stefan
authors.initials: S
authors.lastname: Becker
authors.forename: Claudio O
authors.initials: CO
authors.lastname: Fernandez
authors.forename: Hilal A
authors.initials: HA
authors.lastname: Lashuel
authors.forename: Roland
authors.initials: R
authors.lastname: Benz
authors.forename: Adam
authors.initials: A
authors.lastname: Lange
authors.forename: Markus
authors.initials: M
authors.lastname: Zweckstetter
mesh_terms: D001704:Biopolymers / Q000737:chemistry*; D015153:Blotting, Western; D018625:Microscopy, Atomic Force; D019906:Nuclear Magnetic Resonance, Biomolecular; D051844:alpha-Synuclein / Q000737:chemistry*
chemical_list: D001704:Biopolymers; D051844:alpha-Synuclein