Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer.
Death-associated protein kinase (DAPK) is a pro-apoptotic serine/threonine protein kinase that is dysregulated in a wide variety of cancers. The mechanism by which this occurs has largely been attributed to promoter hypermethylation, which results in gene silencing. However, recent studies indicate that DAPK expression can be detected in some cancers, but its function is still repressed, suggesting that DAPK activity can be subverted at a post-translational level in cancer cells. This review will focus on recent data describing potential mechanisms that may alter the expression, regulation or function of DAPK.
Michie
Alison M
AM
Section of Experimental Haematology, Division of Cancer Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK. A.Michie@udcf.gla.ac.uk
McCaig
Alison M
AM
Nakagawa
Rinako
R
Vukovic
Milica
M
D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000502:physiology*; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics / Q000502:physiology*; D064550:Death-Associated Protein Kinases; D044127:Epigenesis, Genetic; D018095:Germ-Line Mutation; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics; D011110:Polymorphism, Genetic; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000502:physiology*
D051017:Apoptosis Regulatory Proteins; D064550:Death-Associated Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases