BAFF aids generation of IgG anti-ganglioside antibodies in response to Campylobacter jejuni lipo-oligosaccharide.
Ganglioside mimicry of Campylobacter jejuni lipo-oligosaccharide (LOS) can induce the production of IgG anti-ganglioside antibodies, but the generation mechanism has yet to be clarified. B-cell activating factor belonging to the TNF family (BAFF) helped murine B cells produce anti-ganglioside antibodies against C. jejuni LOS. In splenocyte culture, however, anti-ganglioside antibodies were produced in the presence of a soluble transmembrane activator and calcium-modulating and cyclophilin ligand interactor immunoadhesin (TACI-Ig), a receptor for BAFF. TACI-Ig adenoviral vectors failed to decrease production of anti-ganglioside antibodies in mice sensitized with C. jejuni LOS and did not alter IgG subclasses, evidence that BAFF aids but is not essential for the generation of IgG anti-ganglioside antibodies in response to C. jejuni LOS.
Matsumoto
Yukie
Y
Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi, Japan.
Kobata
Tetsuji
T
Odaka
Masaaki
M
Furukawa
Koichi
K
Hirata
Koichi
K
Yuki
Nobuhiro
N
D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology; D053264:B-Cell Activating Factor / Q000276:immunology*; D016123:Campylobacter jejuni / Q000276:immunology; D002469:Cell Separation; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D005732:Gangliosides / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology*; D051379:Mice; D018716:Molecular Mimicry / Q000276:immunology*; D011993:Recombinant Fusion Proteins / Q000276:immunology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001323:Autoantibodies; D001324:Autoantigens; D053264:B-Cell Activating Factor; D005732:Gangliosides; D007074:Immunoglobulin G; D008070:Lipopolysaccharides; D011993:Recombinant Fusion Proteins; C505720:Tnfsf13b protein, mouse; C023023:lipid-linked oligosaccharides; C524618:TACI receptor-IgG Fc fragment fusion protein