The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought.
Plants respond to environmental stresses by altering transcription of genes involved in the response. The chromatin modifier ATX1 regulates expression of a large number of genes; consequently, factors that affect ATX1 activity would also influence expression from ATX1-regulated genes. Here, we demonstrate that dehydration is such a factor implicating ATX1 in the plant's response to drought. In addition, we report that a hitherto unknown Arabidopsis gene, At3g10550, encodes a phosphoinositide 3'-phosphatase related to the animal myotubularins (AtMTM1). Myotubularin activities in plants have not been described and herein, we identify an overlapping set of genes co-regulated by ATX1 and AtMTM under drought conditions. We propose that these shared genes represent the ultimate targets of partially overlapping branches of the pathways of the nuclear ATX1 and the cytoplasmic AtMTM1. Our analyses offer first genome-wide insights into the relationship of an epigenetic factor and a lipid phosphatase from the other end of a shared drought responding pathway in Arabidopsis.
Ding
Yong
Y
UNL Center for Biotechnology and Plant Science Initiative, UNL, Lincoln, NE, USA.
Lapko
Hanna
H
Ndamukong
Ivan
I
Xia
Yuannan
Y
Al-Abdallat
Ayed
A
Lalithambika
Sreedevi
S
Sadder
Monther
M
Saleh
Abdelaty
A
Fromm
Michael
M
Riethoven
Jean-Jack
JJ
Lu
Guoqing
G
Avramova
Zoya
Z
D000222:Adaptation, Physiological / Q000235:genetics*; D000818:Animals; D017360:Arabidopsis / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D029681:Arabidopsis Proteins / Q000235:genetics* / Q000378:metabolism; D002467:Cell Nucleus; D002843:Chromatin; D003593:Cytoplasm; D003681:Dehydration; D055864:Droughts; D044127:Epigenesis, Genetic; D015870:Gene Expression; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D018745:Genome, Plant; D011495:Histone-Lysine N-Methyltransferase; D024101:Mitochondrial Proteins; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics* / Q000378:metabolism; D054558:Protein Tyrosine Phosphatases, Non-Receptor / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
D029681:Arabidopsis Proteins; D002843:Chromatin; D024101:Mitochondrial Proteins; D014157:Transcription Factors; C504056:At2g31650 protein, Arabidopsis; D011495:Histone-Lysine N-Methyltransferase; C550343:myotubulerin protein, Arabidopsis; D010744:Phosphoric Monoester Hydrolases; D054558:Protein Tyrosine Phosphatases, Non-Receptor; C099588:myotubularin