title: Evaluation of azithromycin resistance in Treponema pallidum specimens from Madagascar.
abstract: Treponema pallidum resistance to azithromycin has been documented in the US, Canada, and Ireland. We found no evidence of resistance to azithromycin in specimens from 141 patients with syphilitic lesions in Madagascar suggesting resistance is geographically isolated and supporting use of azithromycin as alternative treatment for early syphilis in Madagascar.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of North Carolina, Madagascar (UNC-MAD), Antananarivo, Madagascar.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Van Damme
authors.forename: Frieda
authors.initials: F
authors.lastname: Behets
authors.forename: Noro
authors.initials: N
authors.lastname: Ravelomanana
authors.forename: Charmie
authors.initials: C
authors.lastname: Godornes
authors.forename: Maria
authors.initials: M
authors.lastname: Khan
authors.forename: Bodo
authors.initials: B
authors.lastname: Randrianasolo
authors.forename: Ny Lovaniaina
authors.initials: NL
authors.lastname: Rabenja
authors.forename: Sheila
authors.initials: S
authors.lastname: Lukehart
authors.forename: Myron
authors.initials: M
authors.lastname: Cohen
authors.forename: Edward
authors.initials: E
authors.lastname: Hook
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017963:Azithromycin / Q000494:pharmacology* / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005260:Female; D006801:Humans; D008270:Madagascar / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009154:Mutation; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D013587:Syphilis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D014210:Treponema pallidum / Q000187:drug effects* / Q000235:genetics; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D012338:RNA, Ribosomal, 23S; D017963:Azithromycin