title: Thromboprophylaxis in patients with acute spinal injuries: an evidence-based analysis.
abstract: BACKGROUND
  The increased risk for venous thromboembolic events following spinal trauma is well established. The purpose of the present study was to examine the literature in order to determine the optimum thromboprophylaxis regimen for patients with acute spinal injuries with or without spinal cord injury.
  
  
  METHODS
  EMBASE, MEDLINE, and Cochrane databases were searched from the earliest available date to April 2008 for clinical trials comparing different methods of thromboprophylaxis in adult patients following acute spinal injuries (with or without spinal cord injury). Outcome measures included the prevalences of deep-vein thrombosis and pulmonary embolism and treatment-related adverse events.
  
  
  RESULTS
  The search yielded 489 studies, but only twenty-one of them fulfilled the inclusion criteria. The prevalence of deep-vein thrombosis was significantly lower in patients without spinal cord injury as compared with patients with spinal cord injury (odds ratio = 6.0; 95% confidence interval = 2.9 to 12.7). Patients with an acute spinal cord injury who were receiving oral anticoagulants had significantly fewer episodes of pulmonary embolism (odds ratio = 0.1; 95% confidence interval = 0.01 to 0.63) than those who were not receiving oral anticoagulants (either untreated controls or patients managed with low-molecular-weight heparin). The start of thromboprophylaxis within the first two weeks after the injury resulted in significantly fewer deep-vein-thrombosis events than delayed initiation did (odds ratio = 0.2; 95% confidence interval = 0.1 to 0.4). With regard to heparin-based pharmacoprophylaxis in patients with spinal trauma, low-molecular-weight heparin significantly reduced the rates of deep-vein thrombosis and bleeding episodes in comparison with the findings in patients who received unfractionated heparin, with odds ratios of 2.6 (95% confidence interval = 1.2 to 5.6) and 7.5 (95% confidence interval = 1.0 to 58.4) for deep-vein thrombosis and bleeding, respectively.
  
  
  CONCLUSIONS
  The prevalence of deep-vein thrombosis following a spine injury is higher among patients who have a spinal cord injury than among those who do not have a spinal cord injury. Therefore, thromboprophylaxis in these patients should start as early as possible once it is deemed safe in terms of potential bleeding complications. Within this population, low-molecular-weight heparin is more effective for the prevention of deep-vein thrombosis, with fewer bleeding complications, than unfractionated heparin is. The use of vitamin K antagonists appeared to be effective for the prevention of pulmonary embolism.
authors.affiliation: Department of Orthopaedics, Rothman Institute, Thomas Jefferson University, 925 Chestnut Street, Philadelphia, PA 19107, USA. ploumis@med.auth.gr
authors.forename: A
authors.initials: A
authors.lastname: Ploumis
authors.forename: R K
authors.initials: RK
authors.lastname: Ponnappan
authors.forename: M G
authors.initials: MG
authors.lastname: Maltenfort
authors.forename: R X
authors.initials: RX
authors.lastname: Patel
authors.forename: J T
authors.initials: JT
authors.lastname: Bessey
authors.forename: T J
authors.initials: TJ
authors.lastname: Albert
authors.forename: J S
authors.initials: JS
authors.lastname: Harrop
authors.forename: C G
authors.initials: CG
authors.lastname: Fisher
authors.forename: C M
authors.initials: CM
authors.lastname: Bono
authors.forename: A R
authors.initials: AR
authors.lastname: Vaccaro
mesh_terms: D000208:Acute Disease; D019317:Evidence-Based Medicine; D006801:Humans; D013119:Spinal Cord Injuries / Q000150:complications*; D013124:Spinal Injuries / Q000150:complications*; D054556:Venous Thromboembolism / Q000517:prevention & control*