title: Application of an automated cardiopulmonary resuscitation device for kidney transplantation from uncontrolled donation after cardiac death donors in the emergency department.
abstract: Vital-organ transplantation has become acceptable as the treatment of choice for end-stage organ failure. If the patient, facing the end of life, wishes to donate organs after cardiac arrest (CA), donation after cardiac death (DCD) is increasingly important for the realization of the patient's desires after CA. In Japan, kidney transplantation from uncontrolled DCD donors, who are identified in modified Maastricht categories II or V, is one of the critical factors in expanding the donor pool. However, according to the forensic code for post-mortems and the requirement of legal consent for transplantation, the time required to meet all procedural requirements has sometimes prohibited organ procurement from uncontrolled DCD donors. We have therefore attempted to use an automated cardiopulmonary resuscitation (CPR) device and maintain arterial pressure for uncontrolled DCD donors during all interim procedures after sudden CA. Comparing kidneys procured from standard DCD donors (n = 10) and uncontrolled DCD donors (n = 4), significant differences were seen in warm ischemic time (WIT), defined as the time from CA to initiation of cooling in situ. However, our early experience showed good tolerance and viability of uncontrolled DCD kidneys. Immediate availability of an automated CPR device might provide a bridge to kidney procurement from uncontrolled DCD donors.
authors.affiliation: Department of Emergency and Critical Care Medicine, Tokyo Medical University Hachioji Medical Center, Hachioji-shi, Tokyo Japan. junya99@tokyo-med.ac.jp
authors.forename: Junya
authors.initials: J
authors.lastname: Morozumi
authors.forename: Naoto
authors.initials: N
authors.lastname: Matsuno
authors.forename: Etsuo
authors.initials: E
authors.lastname: Sakurai
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Takao
authors.initials: T
authors.lastname: Arai
authors.forename: Shoichi
authors.initials: S
authors.lastname: Ohta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001331:Automation; D016887:Cardiopulmonary Resuscitation / Q000295:instrumentation*; D003404:Creatinine / Q000378:metabolism; D016757:Death, Sudden, Cardiac; D004632:Emergency Medical Services; D005260:Female; D006085:Graft Survival; D006801:Humans; D007564:Japan; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors; D009927:Tissue and Organ Procurement; D052096:Warm Ischemia; D055815:Young Adult
chemical_list: D003404:Creatinine