The synthesis of therapeutic locked nucleos(t)ides.
This review highlights progress made during the past 2 to 3 years in the field of therapeutic locked nucleos(t)ides. Synthetic strategies to construct the conformationally locked nucleos(t)ides, their properties and potential therapeutic applications as antiviral compounds, and modified oligonucleotides to modulate antisense and RNAi properties are described.
Zhou
Chuanzheng
C
Uppsala University, Bioorganic Chemistry Program, Box 581, Department of Cell and Molecular Biology, Biomedical Center, SE-75123 Uppsala, Sweden.
Chattopadhyaya
Jyoti
J
D000998:Antiviral Agents / Q000138:chemical synthesis*; D002626:Chemistry, Pharmaceutical / Q000379:methods* / Q000639:trends; D008968:Molecular Conformation; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis*; D009841:Oligonucleotides / Q000138:chemical synthesis*; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis*
D000998:Antiviral Agents; D009705:Nucleosides; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense