title: The role of PET CT to evaluate the response to neoadjuvant chemotherapy in advanced breast cancer: comparison with ultrasonography and magnetic resonance imaging.
abstract: BACKGROUND
  Recently PET is emerged as a method to estimate the response of neoadjuvant chemotherapy (NAC) in advanced breast cancer. This study is aimed to estimate the predictive role of PET CT and other imaging modalities (ultrasound, MRI) through NAC.
  
  
  METHODS
  PET CT was acquired before and after NAC from 41 patients. Pathologic results were classified as pathological complete response (pCR) and non-pCR. The results of clinical responses were assessed with imaging indexes (postTx, postchemotherapy size or peak standardized uptake values (pSUV); delta, the size difference between treatment; RR, reduction rate of tumor size or pSUV), and they were compared with pathologic results.
  
  
  RESULTS
  Seven patients (17.1%) showed pCR. As a result of comparison of the image index, all image indexes of MRI were predictive for pCR (P < 0.05). In contrast, only delta and RR of US, RR of PET CT were significant. The area under curve of delta and RR in MRI were higher (0.91, 0.90) than US (0.83, 0.80) and PET CT (0.62, 0.72). The MRI is superior to the US or PET CT.
  
  
  CONCLUSIONS
  We have concluded that the MRI is better than PET CT for monitoring the effect of NAC in advanced breast cancer.
authors.affiliation: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-Gu, Seoul, Korea.
authors.forename: Jae Hyuck
authors.initials: JH
authors.lastname: Choi
authors.forename: Hye In
authors.initials: HI
authors.lastname: Lim
authors.forename: Se Kyung
authors.initials: SK
authors.lastname: Lee
authors.forename: Wan Wook
authors.initials: WW
authors.lastname: Kim
authors.forename: Sang Min
authors.initials: SM
authors.lastname: Kim
authors.forename: Eunyoon
authors.initials: E
authors.lastname: Cho
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Ko
authors.forename: Boo-Kyung
authors.initials: BK
authors.lastname: Han
authors.forename: Yeon Hee
authors.initials: YH
authors.lastname: Park
authors.forename: Jin-Seok
authors.initials: JS
authors.lastname: Ahn
authors.forename: Young-Hyuck
authors.initials: YH
authors.lastname: Im
authors.forename: Jeong Eon
authors.initials: JE
authors.lastname: Lee
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Yang
authors.forename: Seok Jin
authors.initials: SJ
authors.lastname: Nam
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome; D016217:Ultrasonography, Mammary / Q000379:methods*