Prognostic factors of treatment outcomes in patients with granulocytic sarcoma.
OBJECTIVE
To investigate the possible prognostic factors of survival outcomes in patients with granulocytic sarcoma (GS).


METHODS
We retrospectively investigated the prognostic factors determining survival in 24 patients with GS using Kaplan-Meier survival analysis followed by log rank tests. We evaluated gender, age, location, GS antedating leukemia, underlying disorders, treatment type and stem cell transplantation.


RESULTS
The 5-year survival rate for the patients with GS was 21%. The patients undergoing chemotherapy had a significantly longer survival time compared to those who did not (p = 0.0009). We found no difference in the 5-year survival rate among the patients undergoing chemotherapy combined with radiation or surgery. Patients with chronic myelogenous leukemia and myelodysplastic disorders had worse survival rates (p = 0.0028).


CONCLUSIONS
Early diagnosis with biopsy and early chemotherapy can improve survival outcome. Local radiation or surgery can improve symptoms but does not influence survival outcomes.
Lan
Tsung-Yu
TY
Department of Orthopedics, National Taiwan University and Hospital, Taipei, Taiwan, ROC.
Lin
Dong-Tsamn
DT
Tien
Hwei-Fang
HF
Yang
Rong-Sen
RS
Chen
Chih-Yu
CY
Wu
Karl
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000401:mortality / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D023981:Sarcoma, Myeloid / Q000175:diagnosis / Q000235:genetics / Q000401:mortality / Q000628:therapy*; D014178:Translocation, Genetic; D016896:Treatment Outcome; D055815:Young Adult
D000970:Antineoplastic Agents