title: Differentially expressed microRNAs in small cell lung cancer.
abstract: Expression of microRNAs (miRNAs) is characteristically altered in cancer, and they may play a role in cancer development and progression. The authors performed microarray and real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) analyses to determine the miRNA expression profile of primary small cell lung cancer. Here we show that at least 24 miRNAs are differentially expressed between normal lung and primary small cell lung cancer (SCLC) tumors. These include miR-301, miR-183/96/182, miR-126, and miR-223, which are microRNAs deregulated in other tumor types as well; and other miRNAs, such as miR-374 and miR-210, not previously reported in association with lung cancer. The aberrant miRNA profile of SCLC may offer new insights in the biology of this aggressive tumor, and could potentially provide novel diagnostic markers.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Debrecen Medical and Health Science Center, Debrecen, Hungary.
authors.forename: Edit
authors.initials: E
authors.lastname: Miko
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Czimmerer
authors.forename: Eszter
authors.initials: E
authors.lastname: Csánky
authors.forename: Gábor
authors.initials: G
authors.lastname: Boros
authors.forename: Júlia
authors.initials: J
authors.lastname: Buslig
authors.forename: Balázs
authors.initials: B
authors.lastname: Dezso
authors.forename: Beáta
authors.initials: B
authors.lastname: Scholtz
mesh_terms: D000328:Adult; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D055752:Small Cell Lung Carcinoma / Q000235:genetics* / Q000473:pathology; D012907:Smoking
chemical_list: D035683:MicroRNAs