Quiet gene circuit more fragile than its noisy peer.
Why is a particular architecture for a pathway chosen over seemingly equivalent alternatives? Cağatay et al. (2009) use a synthetic biology approach to show that fluctuations--or noise--in protein levels may play a key role in determining which network design is selected during evolution.
Bollenbach
Tobias
T
Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
Kishony
Roy
R
D001412:Bacillus subtilis / Q000235:genetics / Q000502:physiology*; D005075:Biological Evolution; D053263:Gene Regulatory Networks; D008954:Models, Biological