title: Influence of catechins on bystander responses in CHO cells induced by alpha-particle irradiation.
abstract: In this work, we studied alpha-particle induced and medium-mediated bystander effects in Chinese hamster ovary (CHO) cells through micronucleus (MN) assay. We showed that signal transduction from irradiated cells to bystander cells occur within a short time after irradiation. We then studied the effects of ROS (reactive oxygen species)-scavenging catechins in the medium before irradiation. We observed decreases in the percentage of bystander cells with MN formation and thus proved the protection effect of catechins on bystander cells from radiation.
authors.affiliation: Department of Physics and Materials Science, City University of Hong Kong, Kowloon Tong, Hong Kong.
authors.forename: Y L
authors.initials: YL
authors.lastname: Law
authors.forename: T P W
authors.initials: TP
authors.lastname: Wong
authors.forename: K N
authors.initials: KN
authors.lastname: Yu
mesh_terms: D000512:Alpha Particles; D000818:Animals; D024201:Bystander Effect / Q000187:drug effects* / Q000528:radiation effects; D016466:CHO Cells; D002392:Catechin / Q000008:administration & dosage*; D002869:Chromosome Aberrations / Q000187:drug effects* / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D011836:Radiation Tolerance / Q000187:drug effects*; D011837:Radiation-Protective Agents / Q000008:administration & dosage
chemical_list: D011837:Radiation-Protective Agents; D002392:Catechin