title: Synthesis and antitumor evaluation of analogues of the marine pyrroloiminoquinone tsitsikammamines.
abstract: Two series of analogues of the marine pyrroloiminoquinone alkaloids tsitsikammamine have been synthesized on the basis of a Michael addition between 2'-amino-1-(4-methoxyphenyl)-ethanol and two indolediones. All the compounds were evaluated in vitro for antiproliferative activity against distinct cancer cell lines.
authors.affiliation: Université Paul Sabatier, UMR CNRS 5068, Laboratoire de Synthèse et Physicochimie de Molécules d'Intérêt Biologique, 118 route de Narbonne, 31062 Toulouse Cédex 9, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Rives
authors.forename: Benjamin
authors.initials: B
authors.lastname: Le Calvé
authors.forename: Tamara
authors.initials: T
authors.lastname: Delaine
authors.forename: Laurent
authors.initials: L
authors.lastname: Legentil
authors.forename: Robert
authors.initials: R
authors.lastname: Kiss
authors.forename: Evelyne
authors.initials: E
authors.lastname: Delfourne
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D009792:Oceans and Seas; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011804:Quinolines