[Elimination of NSE and MBP into cerebrospinal fluid and blood in acute experimental autoimmune encephalomyelitis].
An immuno-enzyme assay of NSE and MBP in the cerebrospinal fluid (CFS) and blood serum of rats during the development of acute experimental autoimmune encephalomyelitis revealed the increase of NSE, a neuronal marker, and MBP, a marker for myelin. The investigation has shown that the increased level of NSE in CSF was prior to the increased concentration of MBP. The changes of these neurospecific proteins (NSP) in the serum were not the same as in the CSF. The analysis of the ratio between NSP concentrations in CSF to serum revealed the initial marked decrease of BBB permeability to MBP but not to NSE.
Davydovskaia
M V
MV
Lebedev
S B
SB
Gurina
O I
OI
Chekhonin
V P
VP
D000208:Acute Disease; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier / Q000502:physiology; D004195:Disease Models, Animal; D004679:Encephalomyelitis / Q000276:immunology / Q000378:metabolism*; D005260:Female; D004676:Myelin Basic Protein; D009419:Nerve Tissue Proteins / Q000097:blood* / Q000134:cerebrospinal fluid*; D009836:Oligodendroglia; D010751:Phosphopyruvate Hydratase / Q000097:blood* / Q000134:cerebrospinal fluid*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012720:Severity of Illness Index; D014157:Transcription Factors / Q000097:blood* / Q000134:cerebrospinal fluid*
D015415:Biomarkers; C436006:Mbp protein, rat; D004676:Myelin Basic Protein; D009419:Nerve Tissue Proteins; D014157:Transcription Factors; D010751:Phosphopyruvate Hydratase