New small molecule inhibitors of hepatitis C virus.
New small molecule inhibitors of HCV were discovered by screening a small library of indoline alkaloid-type compounds. An automated assay format was employed which allowed identification of dimerization inhibitors of core, the capsid protein of the virus. These compounds were subsequently shown to block production of infectious virus in hepatoma cells.
Wei
Wanguo
W
Department of Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA 02215, USA.
Cai
Cuifang
C
Kota
Smitha
S
Takahashi
Virginia
V
Ni
Feng
F
Strosberg
A Donny
AD
Snyder
John K
JK
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D016174:Hepacivirus / Q000187:drug effects*; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000494:pharmacology
D000998:Antiviral Agents; D026121:Indole Alkaloids