Revisiting the parietal cell.
The parietal cell is responsible for secreting concentrated hydrochloric acid into the gastric lumen. To fulfill this task, it is equipped with a broad variety of functionally coupled apical and basolateral ion transport proteins. The concerted scientific effort over the last years by a variety of researchers has provided us with the molecular identity of many of these transport mechanisms, thereby contributing to the clarification of persistent controversies in the field. This article will briefly review the current model of parietal cell physiology and ion transport in particular and will update the existing models of apical and basolateral transport in the parietal cell.
Kopic
Sascha
S
Dept. of Surgery, Yale School of Medicine, BML 265, 310 Cedar St., New Haven, CT 06511. john.geibel@yale.edu.
Murek
Michael
M
Geibel
John P
JP
D000263:Adenylate Kinase / Q000378:metabolism; D017920:Antiporters / Q000235:genetics; D001692:Biological Transport; D027682:Cation Transport Proteins / Q000378:metabolism; D004063:Digestion; D005744:Gastric Acid / Q000378:metabolism; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions / Q000378:metabolism; D008954:Models, Biological; D010295:Parietal Cells, Gastric / Q000201:enzymology / Q000502:physiology*; D013270:Stomach / Q000502:physiology*; D000076988:Sulfate Transporters
D017920:Antiporters; D027682:Cation Transport Proteins; D007477:Ions; C455626:SLC26A7 protein, human; D000076988:Sulfate Transporters; D000263:Adenylate Kinase; D017506:H(+)-K(+)-Exchanging ATPase