title: Synthesis and antimycobacterial activity of a novel series of isonicotinylhydrazide derivatives.
abstract: A novel series of 14 new isonicotinyl hydrazide derivatives 2a-g, 3a-g containing a 4-thiazolidinone / 2-azetidinone nucleus were synthesized by reacting N'-substituted arylidene / heteroarylidene isonicotinyl hydrazide 1a-g with thioglycollic acid in the presence of dry benzene and with chloroacetyl chloride in the presence of triethylamine, respectively. Structures of all newly synthesized compounds were characterized on the basis of elemental analyses and spectral data (IR and (1)H-NMR). All the title compounds were tested for their in-vitro antimycobacterial activity against Mycobacterium tuberculosis H(37)Rv using Alamar-Blue susceptibility test, and the activity is expressed as the minimum inhibitory concentration (MIC) in microg/mL. Among the series, compounds 2b, 2g, 3b, and 3g displayed an encouraging antimycobacterial activity profile as compared to that of the reference drugs isoniazid / rifampicin.
authors.affiliation: Department of Pharmaceutical Chemistry, KLES' College of Pharmacy, Vidyanagar, Hubli, Karnataka, India.
authors.forename: Sandip
authors.initials: S
authors.lastname: Jaju
authors.forename: Mahesh
authors.initials: M
authors.lastname: Palkar
authors.forename: Veeresh S
authors.initials: VS
authors.lastname: Maddi
authors.forename: Pradeepkumar
authors.initials: P
authors.lastname: Ronad
authors.forename: Shivalingarao
authors.initials: S
authors.lastname: Mamledesai
authors.forename: Darbhamulla
authors.initials: D
authors.lastname: Satyanarayana
authors.forename: Mangala
authors.initials: M
authors.lastname: Ghatole
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007538:Isoniazid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D007538:Isoniazid