title: Perfusion CT in squamous cell carcinoma of the upper aerodigestive tract: long-term predictive value of baseline perfusion CT measurements.
abstract: OBJECTIVE
  PCT studies hold short-term predictive value in patients treated with chemoradiotherapy. Our aim was to examine the long-term predictive value of baseline PCT studies for local tumor control and overall survival in SCCA of the upper aerodigestive tract treated with chemoradiotherapy.
  
  
  METHODS
  Eighty-four patients with advanced SCCA underwent PCT followed by concomitant chemoradiation. The acquired perfusion maps represented BF, BV, MTT, and PS. Visual analysis of the parametric maps for identification of tumor perfusion patterns was conducted. ROC curves, t tests, and Kaplan-Meier survival curves were plotted for local disease control and overall survival.
  
  
  RESULTS
  The median time of local tumor control was 24 months. The BF and PS values were significantly higher in patients who had no recurrence than in those with local failure (P < or = .02). The BF and PS were predictive (P < or = .0006) but BV and MTT held no significant predictive values for local tumor control. The patients with high BF and PS had a longer local tumor control than the patients with hypoperfused tumors (P = .0007). A visually detected BF-BV mismatch had a sensitivity/specificity of 63%/66% (P = .03) and 59%/69% (P = .03) for local tumor control and OS, respectively. Patients without mismatch lived significantly longer than patients with mismatch (P = .01).
  
  
  CONCLUSIONS
  BF, PS, and mismatch of BF-BV are significant predictors of local tumor control after chemoradiation in SCCA of the upper aerodigestive tract.
authors.affiliation: Department of Neuroradiology, Eberhard Karls University, Tübingen, Germany. Sotirios.Bisdas@med.uni-tuebingen.de
authors.forename: S
authors.initials: S
authors.lastname: Bisdas
authors.forename: Z
authors.initials: Z
authors.lastname: Rumboldt
authors.forename: K
authors.initials: K
authors.lastname: Surlan-Popovic
authors.forename: M
authors.initials: M
authors.lastname: Baghi
authors.forename: T S
authors.initials: TS
authors.lastname: Koh
authors.forename: T J
authors.initials: TJ
authors.lastname: Vogl
authors.forename: M G
authors.initials: MG
authors.lastname: Mack
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D009959:Oropharyngeal Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D011878:Radiotherapy; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents