title: Lab-on-a-chip with beta-poly(vinylidene fluoride) based acoustic microagitation.
abstract: This paper reports a fully integrated disposable lab-on-a-chip with acoustic microagitation based on a piezoelectric ss-poly(vinylidene fluoride) (ss-PVDF) polymer. The device can be used for the measurement, by optical absorption spectroscopy, of biochemical parameters in physiological fluids. It comprises two dies: the fluidic die that contains the reaction chambers fabricated in SU-8 and the ss-PVDF polymer deposited underneath them; and the detection die that contains the photodetectors, its readout electronics, and the piezoelectric actuation electronics, all fabricated in a CMOS microelectronic process. The microagitation technique improves mixing and shortens reaction time. Further, it generates heating, which also improves the reaction time of the fluids. In this paper, the efficiency of the microagitation system is evaluated as a function of the amplitude and the frequency of the signal actuation. The relative contribution of the generated heating is also discussed. The system is tested for the measurement of the uric acid concentration in urine.
authors.affiliation: Department of Industrial Electronics, University of Minho, 4800-058 Guimarães, Portugal. vanessa@dei.uminho.pt
authors.forename: V F
authors.initials: VF
authors.lastname: Cardoso
authors.forename: S O
authors.initials: SO
authors.lastname: Catarino
authors.forename: J
authors.initials: J
authors.lastname: Serrado Nunes
authors.forename: L
authors.initials: L
authors.lastname: Rebouta
authors.forename: J G
authors.initials: JG
authors.lastname: Rocha
authors.forename: S
authors.initials: S
authors.lastname: Lanceros-Méndez
authors.forename: G
authors.initials: G
authors.lastname: Minas
mesh_terms: D000162:Acoustics / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008567:Membranes, Artificial; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D011145:Polyvinyls / Q000737:chemistry*; D018511:Systems Integration; D005465:Fluorocarbon Polymers
chemical_list: D008567:Membranes, Artificial; D011145:Polyvinyls; C024865:polyvinylidene fluoride; D005465:Fluorocarbon Polymers