title: Expression of estrogen and progesterone receptors in vestibular schwannomas and their clinical significance.
abstract: OBJECTIVE
  The objective was to determine the expression of estrogen and progesterone receptors in vestibular schwannomas as well as to determine predictive factors for estrogen and progesterone receptor positivity.
  
  
  METHODS
  The study included 100 cases of vestibular schwannomas operated from January 2006 to June 2009. The clinical details were noted from the medical case files. Formaldehyde-fixed parafiin-embedded archival vestibular schwannomas specimens were used for the immunohistochemical assessment of estrogen and progesterone receptors.
  
  
  RESULTS
  Neither estrogen nor progesterone receptors could be detected in any of our cases by means of well known immunohistochemical method using well documented monoclonal antibodies. In the control specimens, a strongly positive reaction could be seen.
  
  
  CONCLUSIONS
  No estrogen and progesterone receptor could be found in any of our 100 cases of vestibular schwannomas. Hence our study does not support a causative role of estrogen and progesterone in the growth of vestibular schwannoma as well as hormonal manipulation in the treatment of this tumor.
authors.affiliation: Department of Pathology and Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, India. sushilapath@yahoo.com
authors.forename: Sushila
authors.initials: S
authors.lastname: Jaiswal
authors.forename: Vinita
authors.initials: V
authors.lastname: Agrawal
authors.forename: Awadhesh Kumar
authors.initials: AK
authors.lastname: Jaiswal
authors.forename: Rakesh
authors.initials: R
authors.lastname: Pandey
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Mahapatra
mesh_terms: D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D009442:Neurilemmoma / Q000378:metabolism* / Q000473:pathology; D016612:Paraffin Embedding; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D015837:Vestibular Diseases / Q000378:metabolism* / Q000473:pathology
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone