title: The Maillard reaction. From nutritional problems to preventive medicine.
abstract: The questions we were asked by Dr Edeas, president of the French Society of Antioxidants to discuss in this introductory lecture are the following: (a) the metabolism of glycation; (b) what are its consequences at the cellular level, and (c) their effect on health. As a recent and vast literature is available on these subjects, in the following we present a short survey of some basic data on the proposed subjects, insisting on our own experiments on the cytotoxicity of Maillard products and on a new approach to prevent the aggravation and acceleration of age-related diseases, essentially diabetes type II and its consequences on the cardiovascular system.
authors.affiliation: Laboratoire de recherche ophtalmologique, hôpital Hôtel-Dieu, 1, place du Parvis-Notre-Dame, 75181 Paris cedex 04, France. lrobert5@wanadoo.fr
authors.forename: L
authors.initials: L
authors.lastname: Robert
authors.forename: J
authors.initials: J
authors.lastname: Labat-Robert
authors.forename: A-M
authors.initials: AM
authors.lastname: Robert
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism / Q000517:prevention & control; D002625:Chemistry, Organic / Q000266:history; D048909:Diabetes Complications / Q000378:metabolism / Q000517:prevention & control; D003920:Diabetes Mellitus / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects; D005502:Food / Q000009:adverse effects*; D005511:Food Handling; D005602:France; D005609:Free Radicals / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D017127:Glycation End Products, Advanced / Q000009:adverse effects* / Q000378:metabolism / Q000493:pharmacokinetics; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D015416:Maillard Reaction; D018384:Oxidative Stress; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D012210:Rhamnose / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D005609:Free Radicals; D017127:Glycation End Products, Advanced; D017382:Reactive Oxygen Species; D012210:Rhamnose