Beneficial metabolic effects of the Malaysian herb Labisia pumila var. alata in a rat model of polycystic ovary syndrome.
OBJECTIVE
New options are needed to prevent and treat metabolic disorders associated with polycystic ovary syndrome (PCOS). Labisia pumila var. alata (LPva)-a Malaysian herb thought to have phytoestrogenic effects-has shown promise in reducing body weight gain in ovariectomized rats. In this study, we investigated the effect of LPva on body composition and metabolic features in female rats treated continuously with dihydrotestosterone, starting before puberty, to induce PCOS.


METHODS
At 9 weeks of age, the PCOS rats were randomly subdivided into two groups; PCOS LPva and PCOS control. PCOS LPva rats received a daily oral dose of LPva (50mg/kg body weight), dissolved in 1 ml of deionised water, for 4-5 weeks. PCOS controls received 1 ml of deionised water on the same schedule.


RESULTS
LPva increased uterine weight (27%) and insulin sensitivity (36%) measured by euglycemic hyperinsulinemic clamp. Plasma resistin levels were increased and lipid profile was improved in LPva rats. In adipose tissue, LPva decreased leptin mRNA expression but did not affect expression of resistin and adiponectin. No effects on body composition, adipocyte size, or plasma leptin levels were observed.


CONCLUSIONS
LPva increases uterine weight, indicating estrogenic effects, and improves insulin sensitivity and lipid profile in PCOS rats without affecting body composition.
Mannerås
L
L
Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
Fazliana
M
M
Wan Nazaimoon
W M
WM
Lönn
M
M
Gu
H F
HF
Ostenson
C G
CG
Stener-Victorin
E
E
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008296:Malaysia; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D028321:Plant Preparations / Q000302:isolation & purification / Q000627:therapeutic use; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000378:metabolism*; D029623:Primulaceae; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D028321:Plant Preparations