Self-assembly of carbon nanotubes into two-dimensional geometries using DNA origami templates.
A central challenge in nanotechnology is the parallel fabrication of complex geometries for nanodevices. Here we report a general method for arranging single-walled carbon nanotubes in two dimensions using DNA origami-a technique in which a long single strand of DNA is folded into a predetermined shape. We synthesize rectangular origami templates ( approximately 75 nm x 95 nm) that display two lines of single-stranded DNA 'hooks' in a cross pattern with approximately 6 nm resolution. The perpendicular lines of hooks serve as sequence-specific binding sites for two types of nanotubes, each functionalized non-covalently with a distinct DNA linker molecule. The hook-binding domain of each linker is protected to ensure efficient hybridization. When origami templates and DNA-functionalized nanotubes are mixed, strand displacement-mediated deprotection and binding aligns the nanotubes into cross-junctions. Of several cross-junctions synthesized by this method, one demonstrated stable field-effect transistor-like behaviour. In such organizations of electronic components, DNA origami serves as a programmable nanobreadboard; thus, DNA origami may allow the rapid prototyping of complex nanotube-based structures.
Maune
Hareem T
HT
California Institute of Technology, Pasadena, California 91125, USA.
Han
Si-Ping
SP
Barish
Robert D
RD
Bockrath
Marc
M
Goddard
William A
WA
Rothemund
Paul W K
PW
Winfree
Erik
E
D001483:Base Sequence; D004277:DNA, Single-Stranded / Q000737:chemistry*; D004563:Electrochemistry; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D009690:Nucleic Acid Conformation
D004277:DNA, Single-Stranded; D037742:Nanotubes, Carbon