Hypoglycaemic seizure and neonatal acute adrenal insufficiency after maternal exposure to prednisone during pregnancy: a case report.
Neonatal acute adrenal insufficiency (AAI) is a rare but severe condition. We report a case of AAI following maternal exposure to moderate doses of corticosteroids during pregnancy. The neonate, born at term, presented with hypoglycaemia complicated by seizures. The AAI was confirmed by endocrine tests and after exclusion of differential diagnoses. Early diagnosis and treatment led to full recovery.
Saulnier
Pierre-Jean
PJ
Department of Clinical Pharmacology and Regional Center of Pharmacovigilance, CHU de Poitiers, Poitiers, France. p.j.saulnier@chu-poitiers.fr
Piguel
Xavier
X
Perault-Pochat
Marie Christine
MC
Csizmadia-Bremaud
Cassandra
C
Saulnier
Jean-Pascal
JP
D000208:Acute Disease; D000309:Adrenal Insufficiency / Q000139:chemically induced*; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D007231:Infant, Newborn; D008297:Male; D011241:Prednisone / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012640:Seizures / Q000139:chemically induced*
D000893:Anti-Inflammatory Agents; D011241:Prednisone