Synthesis, regioselective hydrogenolysis, partial hydrogenation, and conformational study of dioxane and dioxolane-type (9'-anthracenyl)methylene acetals of sugars.
Dioxane-type (9'-anthracenyl)methylene acetal of methyl 2,3-di-O-methyl-alpha-D-glucopyranoside was cleaved with LiAlH(4)/AlCl(3) (3:1) or with Na(CN)BH(3)-HCl regioselectively to provide the 4- or 6-O-(9'-anthracenyl)methyl ether, respectively. Hydrogenolytic reaction of the exo and endo isomers of dioxolane-type acetals proved to be directed by the configuration of the acetalic carbon as well as by the intramolecular participation of the adjacent-free hydroxyl; ring-opening reaction of the endo isomer of the methyl 2,3-O-(9'-anthracenyl)methylene-alpha-L-rhamnopyranoside took place with complete selectivity resulting in the axial (9'-anthracenyl)methyl ether, whereas a 1:1 mixture of the axial and equatorial ethers was formed upon the same reaction of the exo isomer. Catalytic hydrogenation of the sugar acetals resulted in (9',10'-dihydro-9'-anthracenyl)methylene derivatives without affecting the acetalic center. High-temperature molecular dynamics simulations and DFT (Density Functional Theory) geometry optimizations were carried out to study the conformation of the dioxane-type (9',10'-dihydro-9'-anthracenyl)methylene acetal.
Jakab
Zsolt
Z
Research Group for Carbohydrates of the Hungarian Academy of Sciences, University of Debrecen, PO Box 94, H-4010 Debrecen, Hungary.
Mándi
Attila
A
Borbás
Anikó
A
Bényei
Attila
A
Komáromi
István
I
Lázár
László
L
Antus
Sándor
S
Lipták
András
A
D000080:Acetals; D002241:Carbohydrates / Q000737:chemistry*; D004146:Dioxanes / Q000737:chemistry*; D004148:Dioxolanes / Q000737:chemistry*; D006358:Hot Temperature; D006865:Hydrogenation; D008968:Molecular Conformation; D056004:Molecular Dynamics Simulation
D000080:Acetals; D002241:Carbohydrates; D004146:Dioxanes; D004148:Dioxolanes; C010962:formal glycol