title: Single HCC between 2 and 5 cm: the grey zone: surgeon's perspective.
abstract: In the treatment of hepatocellular carcinoma (HCC), control of the tumor itself, vascular invasion, and minute intrahepatic metastases is the main important factor to be considered. Based on previously reported indirect evidence, liver resection would seem to have advantages over percutaneous ablation for single HCCs measuring between 2 and 5 cm in diameter. In conclusion, liver function permitting, resection would be the therapeutic option of first choice. In cases with poor liver functional reserve, liver transplantation would be a good therapeutic option, depending on the age of the patient.
authors.affiliation: Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Norihiro
authors.initials: N
authors.lastname: Kokudo
authors.forename: Keiji
authors.initials: K
authors.lastname: Sano
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Makuuchi
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D003657:Decision Making; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D009367:Neoplasm Staging