[Peripheral tolerance to allergen mediated by regulatory T cells].
Foxp3+ CD25+ CD4+ regulatory T cells(Tregs), which constitute 10% of peripheral CD4+ T lymphocytes, play an essential role in maintaining immunological self-tolerance and in suppressing excessive immune responses deleterious to the host. Tregs can suppress a variety of immune reactions including autoimmune diseases, allergy, tumor immunity, and reactions in transplantation. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery. Recent research reveals the cellular and molecular basis of development, expansion and suppressive function of Tregs. Immune reactions in tumor immunity and autoimmune diseases can be monitored and controlled in a novel strategy by targeting Tregs.
Yamaguchi
Tomoyuki
T
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University.
Sakaguchi
Shimon
S
D000485:Allergens / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
D000485:Allergens