title: A new bifunctional Gd(III) complex of enhanced efficacy for MR-molecular imaging applications.
abstract: Increasing the length of the carboxyamide arm of a GdDOTA monoamide (DOTA = 1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl)cyclododecane) complex from acetic to propionic accelerates the water exchange rate (k(ex)) by nearly two orders of magnitude; the (1)H relaxivity of the corresponding macromolecular derivatives may then be remarkably enhanced in MRI-based molecular imaging applications, as exemplified in the case of micellar systems.
authors.affiliation: Dipartimento di Scienze dell'Ambiente e della Vita, Università del Piemonte Orientale Amedeo Avogadro, Viale T. Michel 11, I-15121, Alessandria, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Tei
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gugliotta
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Baranyai
authors.forename: Mauro
authors.initials: M
authors.lastname: Botta
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D015195:Drug Design; D005682:Gadolinium / Q000737:chemistry*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D007089:Image Enhancement; D008024:Ligands; D008279:Magnetic Resonance Imaging
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D006573:Heterocyclic Compounds, 1-Ring; D008024:Ligands; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D005682:Gadolinium