title: Novel pentacyclic seco-prezizaane-type sesquiterpenoids with neurotrophic properties from Illicium jiadifengpi.
abstract: Three novel seco-prezizaane-type sesquiterpenoids, jiadifenolide (1), jiadifenoxolane A (2), and jiadifenoxolane B (3), were isolated from the pericarps of Illicium jiadifengpi. Their pentacyclic cage structures were determined by 2D-NMR methods, chemical conversion, and single-crystal X-ray analysis. Compounds 1 and 2 strongly promote neurite outgrowth in primary cultured rat cortical neurons at concentrations ranging from 0.01 to 10 muM.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
authors.forename: Miwa
authors.initials: M
authors.lastname: Kubo
authors.forename: Chihiro
authors.initials: C
authors.lastname: Okada
authors.forename: Jian-Mei
authors.initials: JM
authors.lastname: Huang
authors.forename: Kenichi
authors.initials: K
authors.lastname: Harada
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hioki
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Fukuyama
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D029523:Illicium / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013045:Species Specificity; D013237:Stereoisomerism
chemical_list: D012717:Sesquiterpenes; C546282:jiadifenolide; C546284:jiadifenoxolane A; C546283:jiadifenoxolane B