title: Vascular morphogenesis in the zebrafish embryo.
abstract: During embryonic development, the vertebrate vasculature is undergoing vast growth and remodeling. Blood vessels can be formed by a wide spectrum of different morphogenetic mechanisms, such as budding, cord hollowing, cell hollowing, cell wrapping and intussusception. Here, we describe the vascular morphogenesis that occurs in the early zebrafish embryo. We discuss the diversity of morphogenetic mechanisms that contribute to vessel assembly, angiogenic sprouting and tube formation in different blood vessels and how some of these complex cell behaviors are regulated by molecular pathways.
authors.affiliation: Department of Cell Biology, Biozentrum der Universität Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
authors.forename: Elín
authors.initials: E
authors.lastname: Ellertsdóttir
authors.forename: Anna
authors.initials: A
authors.lastname: Lenard
authors.forename: Yannick
authors.initials: Y
authors.lastname: Blum
authors.forename: Alice
authors.initials: A
authors.lastname: Krudewig
authors.forename: Lukas
authors.initials: L
authors.lastname: Herwig
authors.forename: Markus
authors.initials: M
authors.lastname: Affolter
authors.forename: Heinz-Georg
authors.initials: HG
authors.lastname: Belting
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000196:embryology*; D004625:Embryo, Nonmammalian / Q000378:metabolism; D009024:Morphogenesis; D015027:Zebrafish / Q000196:embryology*