title: Catecholaminergic polymorphic ventricular tachycardia: A paradigm to understand mechanisms of arrhythmias associated to impaired Ca(2+) regulation.
abstract: In the 8 years since the discovery of the genetic bases of catecholaminergic polymorphic ventricular tachycardia (CPVT), we have witnessed a remarkable improvement of knowledge on arrhythmogenic mechanisms involving disruption of cardiac Ca(2+) homeostasis. Studies on the consequences of RyR2 and CASQ2 mutations in cellular systems and mouse models have shed new light on pathways that are also implicated in arrhythmias occurring in highly prevalent diseases, such as heart failure. This research track has also led to the identification of therapeutic targets of potential clinical impact to abate the burden of sudden death in CPVT. Here, we review the current knowledge on the pathophysiology of CPVT also highlighting the existing controversies and possible future development.
authors.affiliation: Cardiovascular Genetics, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.
authors.forename: Marina
authors.initials: M
authors.lastname: Cerrone
authors.forename: Carlo
authors.initials: C
authors.lastname: Napolitano
authors.forename: Silvia G
authors.initials: SG
authors.lastname: Priori
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D006801:Humans; D051379:Mice; D010375:Pedigree; D011110:Polymorphism, Genetic / Q000235:genetics*; D019837:Ryanodine Receptor Calcium Release Channel; D017180:Tachycardia, Ventricular / Q000235:genetics* / Q000503:physiopathology*
chemical_list: D002395:Catecholamines; D019837:Ryanodine Receptor Calcium Release Channel; D002118:Calcium