A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins.
The complex Ru([9]aneS(3))(gly)Cl (gly = glycine) was obtained from the reaction of the precursor Ru([9]aneS(3))dmsoCl(2) with glycine and encapsulated into native beta-CD, a hydroxypropylated derivative HPbetaCD, and the methylated cyclodextrins TRIMEB and CRYSMEB. All four inclusion compounds were obtained with a 1:1 host:guest stoichiometry and characterised in the solid-state by powder X-ray diffraction, thermogravimetric analysis (TGA), and (13)C{(1)H} CP/MAS NMR and FTIR spectroscopies. The cytostatic and antiproliferative activity of the complex Ru([9]aneS(3))(gly)Cl and its four CD inclusion compounds was tested on the human osteosarcoma MG-63 cell line and the results compared to the inhibitory effect exerted by the pure cyclodextrins.
Marques
Joana
J
Department of Chemistry, CICECO, University of Aveiro, 3810-193, Aveiro, Portugal.
Santos
Teresa M
TM
Marques
Maria Paula
MP
Braga
Susana S
SS
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001859:Bone Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D005998:Glycine / Q000737:chemistry*; D006801:Humans; D012516:Osteosarcoma / Q000188:drug therapy; D047392:beta-Cyclodextrins / Q000737:chemistry*
D000970:Antineoplastic Agents; D056831:Coordination Complexes; D047392:beta-Cyclodextrins; D005998:Glycine