title: Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA.
abstract: Triplex forming oligonucleotides (TFOs) modified with C5-alkynyl functionalized LNA (locked nucleic acid) monomers display extraordinary thermal affinity toward double stranded DNA targets, excellent discrimination of Hoogsteen-mismatched targets, and high stability against 3?-exonucleases.
authors.affiliation: Dept. of Chemistry, Univ. of Idaho, ID-83844, USA.
authors.forename: Sujay P
authors.initials: SP
authors.lastname: Sau
authors.forename: Pawan
authors.initials: P
authors.lastname: Kumar
authors.forename: Brooke A
authors.initials: BA
authors.lastname: Anderson
authors.forename: Michael E
authors.initials: ME
authors.lastname: Østergaard
authors.forename: Lee
authors.initials: L
authors.lastname: Deobald
authors.forename: Andrzej
authors.initials: A
authors.lastname: Paszczynski
authors.forename: Pawan K
authors.initials: PK
authors.lastname: Sharma
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Hrdlicka
mesh_terms: D000480:Alkynes; D001665:Binding Sites; D004247:DNA / Q000037:antagonists & inhibitors*; D016503:Drug Delivery Systems / Q000379:methods*; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000480:Alkynes; D009841:Oligonucleotides; C477371:locked nucleic acid; C051802:triplex DNA; D004247:DNA