[Significance of beta-catenin and Cyclin D1 express in glioma].
OBJECTIVE
To investigate the expression and the significance of beta-catenin and Cyclin D1 in gliomas.


METHODS
The SABC immunohistochemistry were used to detect the expression of beta-catenin and Cyclin D1 in 49 brain gliomas and 5 normal brain tissues.


RESULTS
The beta-catenin positive ratio in normal brain tissues and glioma samples are 2/5 and 38/49(P<0.01) respectively, and the Cyclin D1 positive ratio in normal brain tissues and gliomas are 1/5 and 42/49(P<0.01); Compared with the normal brain tissue, both the immunohistochemical expression of beta-catenin and Cyclin D1 were up-regulated(P<0.05), and the expression of beta-catenin and Cyclin D1 between the normal brain tissues and gliomas exhibited significantly difference (P<0.01).


CONCLUSIONS
beta-catenin and Cyclin D1 increased in gliomas may be precipitate the tumorigenesis of glioma.
Zhang
Zhi-qiang
ZQ
Department of Neurosurgery, The 161st Hospital of PLA, Wuhan 430010, China. zzq882211@sina.com
Chen
Hong-qing
HQ
Chen
Ying-hong
YH
Cheng
Xin-fu
XF
D000293:Adolescent; D000328:Adult; D000368:Aged; D002467:Cell Nucleus / Q000378:metabolism; D002648:Child; D019938:Cyclin D1 / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D015854:Up-Regulation; D055815:Young Adult; D051176:beta Catenin / Q000378:metabolism*
D051176:beta Catenin; D019938:Cyclin D1