[Dramatic efficacy of chemotherapy with 5-fluorouracil and dacarbazine in a patient with metastatic glucagonoma and cardiac insufficiency].
Malignant glucagonoma is an exceptional pancreatic endocrine tumour, with frequent dermatologic symptoms, diabetes and degradation of the general health status. Prognosis is unfavourable when liver metastases are present due to the usual inefficiency of chemotherapy. We report here an observation of a patient who was treated for a glucagonoma with multiple liver metastases, migratory necrolytic erythema, dilated cardiomypathy and diabetes that dramatically improved after a dacarbazin-based chemotherapy, allowing subsequent surgical resection of the primary. The patient was still alive and asymptomatic without progressive disease nearly two years after surgery.
de Mestier
L
L
Service de gastroentérologie-pancréatologie, pôle des maladies de l'appareil digestif, hôpital Beaujon (AP-HP), 100, boulevard Leclerc, 92110 Clichy, France.
Hammel
P
P
Hentic
O
O
Dove
P
P
Lévy
P
P
Ruszniewski
P
P
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002311:Cardiomyopathy, Dilated / Q000150:complications*; D003606:Dacarbazine / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005935:Glucagonoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000601:surgery
D003606:Dacarbazine; D005472:Fluorouracil