Clinical and electrophysiological parameters distinguishing acute-onset chronic inflammatory demyelinating polyneuropathy from acute inflammatory demyelinating polyneuropathy.
Up to 16% of chronic inflammatory demyelinating polyneuropathy (CIDP) patients may present acutely. We performed a retrospective chart review on 30 acute inflammatory demyelinating polyneuropathy (AIDP) and 15 acute-onset CIDP (A-CIDP) patients looking for any clinical or electrophysiological parameters that might differentiate AIDP from acutely presenting CIDP. A-CIDP patients were significantly more likely to have prominent sensory signs. They were significantly less likely to have autonomic nervous system involvement, facial weakness, a preceding infectious illness, or need for mechanical ventilation. With regard to electrophysiological features, neither sural-sparing pattern, sensory ratio >1, nor the presence of A-waves was different between the two groups. This study suggests that patients presenting acutely with a demyelinating polyneuropathy and the aforementioned clinical features should be closely monitored as they may be more likely to have CIDP at follow-up.
Dionne
Annie
A
Department of Clinical Neurological Sciences, Université Laval, 1401 18 rue, Québec City, Québec G1J 1Z4, Canada. annie.dionne.cha@ssss.gouv.qc.ca
Nicolle
Michael W
MW
Hahn
Angelika F
AF
D000200:Action Potentials / Q000502:physiology; D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology; D003937:Diagnosis, Differential; D055724:Electrophysiological Phenomena / Q000502:physiology*; D005152:Facial Muscles / Q000503:physiopathology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D007239:Infections / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000503:physiopathology; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000175:diagnosis* / Q000503:physiopathology*; D012121:Respiration, Artificial; D012189:Retrospective Studies