title: Cost-effectiveness of eradication of Helicobacter pylori in gastric cancer survivors after endoscopic resection of early gastric cancer.
abstract: BACKGROUND
  Clinical effectiveness of Helicobacter pylori eradication in gastric cancer survivors after endoscopic resection of early gastric cancer (EGC) was recently established in a randomized controlled trial. We aimed to establish long-term cost-effectiveness in gastric cancer survivors after endoscopic resection of EGC.
  
  
  METHODS
  A Markov model was constructed to compare the costs and outcomes of the two intervention strategies: (1) eradicate H. pylori after complete resection of EGC by endoscopy (2) do not eradicate. Estimates for variables in the model were obtained by extensive review of published reports. Analyses were made from the Korean public healthcare provider's perspective.
  
  
  RESULTS
  Base-case analysis indicated H. pylori eradication costs less (US$ 29,780 vs. US$ 30,594) than no eradication, and save more lives (mean life expectancy from eradication: 13.60 years vs. 13.55 years). One-way and three-way sensitivity analyses showed the robustness of the cost-effectiveness results.
  
  
  CONCLUSIONS
  In this selective population with very high risk of developing gastric cancer, H. pylori eradication should be considered for reimbursement with priority to prevent subsequent cancer and also reduce health care cost.
authors.affiliation: National Cancer Control Research Institute & Hospital, National Cancer Center, Goyang, Korea.
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Shin
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Yun
authors.forename: Il Ju
authors.initials: IJ
authors.lastname: Choi
authors.forename: Eurah
authors.initials: E
authors.lastname: Koh
authors.forename: Sang Min
authors.initials: SM
authors.lastname: Park
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003362:Cost-Benefit Analysis; D055088:Early Detection of Cancer / Q000191:economics; D004724:Endoscopy; D005260:Female; D017048:Health Care Costs; D016481:Helicobacter Infections / Q000175:diagnosis / Q000191:economics* / Q000382:microbiology / Q000601:surgery; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000191:economics* / Q000382:microbiology / Q000601:surgery; D017741:Survivors; D016896:Treatment Outcome