Estrogens and bladder outlet obstruction.
Increasing evidence indicates a direct interrelationship between benign prostatic hyperplasia and chronic non-bacterial prostatic inflammation in the development of human voiding dysfunction in aging male, which gradually transforms to bladder outlet obstruction (BOO). Increased prevalence of BOO along with the aging process further suggests that estrogen or more precisely decreased androgen to estrogen ratio in serum is involved in the pathogenesis of BOO. In this review, we will analyze the hormonal causes, clinical relevance, and biologically relevant estrogen-modulated animal models potential for BOO study. In light of the data presented in this review, it becomes apparent that direct inhibition of estrogen action may provide important pharmaceutical treatment of the BOO.
Li
Xiangdong
X
State Key Laboratory of the Agro-Biotechnology, Faculty of Biological Sciences, China Agricultural University, No. 2, Yuanmingyuan West Road, Haidian District, Beijing 100193, China. xiangdongli@cau.edu.cn
Rahman
Nafis
N
D000818:Animals; D004195:Disease Models, Animal; D004965:Estrogen Antagonists / Q000494:pharmacology; D004967:Estrogens / Q000378:metabolism*; D006801:Humans; D008297:Male; D001748:Urinary Bladder Neck Obstruction / Q000188:drug therapy / Q000209:etiology*
D004965:Estrogen Antagonists; D004967:Estrogens