[Treating hyponatraemia--not an easy task].
Chronic hyponatraemia and its therapy is a common and often underestimated problem of hospitalized patients. Usually, hyponatraemia is just one of many laboratory features found in such patients. However, rapid correction of chronic hyponatraemia can have devastating neurological consequences, i.e. osmotic myelinolysis. In the following, we describe the mechanisms leading to myelinolysis due to rapid correction of hyponatraemia and answer the questions how much, and at which rate to correct chronic hyponatremia.
Stober
Christina Nicole
CN
Universitätsklinik für Nephrologie und Hypertonie, Inselspital, Bern.
Huynh-Do
Uyen
U
D000284:Administration, Oral; D000369:Aged, 80 and over; D065092:Antidiuretic Hormone Receptor Antagonists; D001552:Benzazepines / Q000008:administration & dosage / Q000627:therapeutic use; D001929:Brain Edema / Q000209:etiology; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D007297:Inpatients; D008279:Magnetic Resonance Imaging; D017590:Myelinolysis, Central Pontine / Q000209:etiology; D012964:Sodium / Q000097:blood; D012965:Sodium Chloride / Q000008:administration & dosage; D013997:Time Factors; D000077602:Tolvaptan; D014057:Tomography, X-Ray Computed
D065092:Antidiuretic Hormone Receptor Antagonists; D001552:Benzazepines; D000077602:Tolvaptan; D012965:Sodium Chloride; D012964:Sodium