Immobilisation versus immediate mobilisation after intrauterine insemination: randomised controlled trial.
OBJECTIVE
To evaluate the effectiveness of 15 minutes of immobilisation versus immediate mobilisation after intrauterine insemination.


METHODS
Randomised controlled trial. Setting One academic teaching hospital and six non-academic teaching hospitals.


METHODS
Women having intrauterine insemination for unexplained, cervical factor, or male subfertility.


METHODS
15 minutes of immobilisation or immediate mobilisation after insemination.


METHODS
Ongoing pregnancy per couple.


RESULTS
391 couples were randomised; 199 couples were allocated to 15 minutes of immobilisation after intrauterine insemination, and 192 couples were allocated to immediate mobilisation (control). The ongoing pregnancy rate per couple was significantly higher in the immobilisation group than in the control group: 27% (n=54) versus 18% (34); relative risk 1.5, 95% confidence interval 1.1 to 2.2 (crude difference in ongoing pregnancy rates: 9.4%, 1.2% to 17%). Live birth rates were 27% (53) in the immobilisation group and 17% (32) in the control group: relative risk 1.6, 1.1 to 2.4 (crude difference for live birth rates: 10%, 1.8% to 18%). In the immobilisation group, the ongoing pregnancy rates in the first, second, and third treatment cycles were 10%, 10%, and 7%. The corresponding rates in the mobilisation group were 7%, 5%, and 5%.


CONCLUSIONS
In treatment with intrauterine insemination, 15 minutes' immobilisation after insemination is an effective modification. Immobilisation for 15 minutes should be offered to all women treated with intrauterine insemination.


BACKGROUND
Current Controlled Trials ISRCTN53294431.
Custers
Inge M
IM
Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands. i.m.custers@amc.uva.nl
Flierman
Paul A
PA
Maas
Pettie
P
Cox
Tessa
T
Van Dessel
Thierry J H M
TJ
Gerards
Mariette H
MH
Mochtar
Monique H
MH
Janssen
Catharina A H
CA
van der Veen
Fulco
F
Mol
Ben Willem J
BW
D000328:Adult; D004434:Early Ambulation / Q000379:methods*; D005260:Female; D006801:Humans; D007103:Immobilization / Q000379:methods*; D007247:Infertility, Female / Q000628:therapy*; D007248:Infertility, Male / Q000628:therapy*; D007315:Insemination, Artificial / Q000379:methods*; D053208:Kaplan-Meier Estimate; D050498:Live Birth; D008297:Male; D008875:Middle Aged; D011247:Pregnancy / Q000502:physiology*; D018873:Pregnancy Rate; D016683:Supine Position / Q000502:physiology; D013997:Time Factors; D055815:Young Adult