title: HLungDB: an integrated database of human lung cancer research.
abstract: The human lung cancer database (HLungDB) is a database with the integration of the lung cancer-related genes, proteins and miRNAs together with the corresponding clinical information. The main purpose of this platform is to establish a network of lung cancer-related molecules and to facilitate the mechanistic study of lung carcinogenesis. The entries describing the relationships between molecules and human lung cancer in the current release were extracted manually from literatures. Currently, we have collected 2585 genes and 212 miRNA with the experimental evidences involved in the different stages of lung carcinogenesis through text mining. Furthermore, we have incorporated the results from analysis of transcription factor-binding motifs, the promoters and the SNP sites for each gene. Since epigenetic alterations also play an important role in lung carcinogenesis, genes with epigenetic regulation were also included. We hope HLungDB will enrich our knowledge about lung cancer biology and eventually lead to the development of novel therapeutic strategies. HLungDB can be freely accessed at http://www.megabionet.org/bio/hlung.
authors.affiliation: Center for Bioinformatics and Computational Biology, and The Institute of Biomedical Sciences, College of Life Science, East China Normal University, Shanghai 200241, China.
authors.forename: Lishan
authors.initials: L
authors.lastname: Wang
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Xiong
authors.forename: Yihua
authors.initials: Y
authors.lastname: Sun
authors.forename: Zhaoyuan
authors.initials: Z
authors.lastname: Fang
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Hongbin
authors.initials: H
authors.lastname: Ji
authors.forename: Tieliu
authors.initials: T
authors.lastname: Shi
mesh_terms: D020816:Amino Acid Motifs; D002471:Cell Transformation, Neoplastic; D019295:Computational Biology / Q000379:methods* / Q000639:trends; D030541:Databases, Genetic; D030561:Databases, Nucleic Acid; D030562:Databases, Protein; D044127:Epigenesis, Genetic; D053263:Gene Regulatory Networks; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods; D020407:Internet; D008175:Lung Neoplasms / Q000235:genetics*; D035683:MicroRNAs / Q000378:metabolism; D012984:Software; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D014157:Transcription Factors