title: Interactive real-time mapping and catheter ablation of the cavotricuspid isthmus guided by magnetic resonance imaging in a porcine model.
abstract: OBJECTIVE
  We investigated the feasibility of real-time magnetic resonance imaging (RTMRI) guided ablation of the cavotricuspid isthmus (CTI) by using a MRI-compatible ablation catheter.
  
  
  RESULTS
  Cavotricuspid isthmus ablation was performed in an interventional RTMRI suite by using a novel 7 French, steerable, non-ferromagnetic ablation catheter in a porcine in vivo model (n = 20). The catheter was introduced and navigated by RTMRI visualization only. Catheter position and movement during manipulation were continuously visualized during the entire intervention. Two porcine prematurely died due to VT/VF. Anatomical completion of the CTI ablation line could be achieved after a mean of 6.3+/-3 RF pulses (RF energy: 1807+/-1016.4 Ws/RF pulse, temperature: 55.9+/-5.9 degrees C) in n = 18 animals. In 15 of 18 procedures (83.3%) a complete CTI block was proven by conventional mapping in the electrophysiological (EP) lab.
  
  
  CONCLUSIONS
  Completely non-fluoroscopic ablation guided by RTMRI using a steerable and non-ferromagnetic catheter is a promising novel technology in interventional electrophysiology.
authors.affiliation: Department of Cardiology/Electrophysiology, University Hospital Eppendorf, University Heart Center, Martinistr 52, D-20246 Hamburg, Germany. b.hoffmann@uke.de
authors.forename: Boris A
authors.initials: BA
authors.lastname: Hoffmann
authors.forename: Andreas
authors.initials: A
authors.lastname: Koops
authors.forename: Thomas
authors.initials: T
authors.lastname: Rostock
authors.forename: Kai
authors.initials: K
authors.lastname: Müllerleile
authors.forename: Daniel
authors.initials: D
authors.lastname: Steven
authors.forename: Roman
authors.initials: R
authors.lastname: Karst
authors.forename: Mark U
authors.initials: MU
authors.lastname: Steinke
authors.forename: Imke
authors.initials: I
authors.lastname: Drewitz
authors.forename: Gunnar
authors.initials: G
authors.lastname: Lund
authors.forename: Susan
authors.initials: S
authors.lastname: Koops
authors.forename: Gerhard
authors.initials: G
authors.lastname: Adam
authors.forename: Stephan
authors.initials: S
authors.lastname: Willems
mesh_terms: D000818:Animals; D001282:Atrial Flutter / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods*; D004594:Electrophysiology; D005240:Feasibility Studies; D018810:Magnetic Resonance Angiography; D053783:Magnetic Resonance Imaging, Interventional; D013552:Swine; D014261:Tricuspid Valve / Q000601:surgery*