Olibanum extract inhibits vascular smooth muscle cell migration and proliferation in response to platelet-derived growth factor.
Olibanum (Boswellia serrata) has been shown to have anti-inflammatory, anti-arthritic and anti-cancer effects. This study determined the role of a water extract of olibanum in platelet-derived growth factor (PDGF)-stimulated proliferation and migration of rat aortic smooth muscle cells (RASMCs). PDGF-BB induced the migration and proliferation of RASMCs that were inhibited by olibanum extract in a dose-dependent manner. The PDGF-BB-increased phosphorylation of p38 mitogen-activated protein kinase (MAPK); the heat shock protein (Hsp) 27 was significantly inhibited by the olibanum extract. The effects of PDGF-BB-induced extracellular signal-regulated kinase1/2 was not altered by the olibanum extract. Treatment with olibanum extract inhibited PDGF-BB-stimulated sprout out growth of aortic rings. These results suggest that the water extract of olibanum inhibits PDGF-BB-stimulated migration and proliferation in RASMCs as well as sprout out growth, which may be mediated by the inhibition of the p38 MAPK and Hsp27 pathways.
Choi
Ok-Byung
OB
Department of Cosmetic Science, College of Natural Science, Hoseo University, Asan 336-795, Korea.
Park
Joo-Hoon
JH
Lee
Ye Jin
YJ
Lee
Chang-Kwon
CK
Won
Kyung-Jong
KJ
Kim
Junghwan
J
Lee
Hwan Myung
HM
Kim
Bokyung
B