title: Formulation and evaluation of press coated tablets for pulsatile drug delivery using hydrophilic and hydrophobic polymers.
abstract: The aim of present investigation was to develop press coated tablet for pulsatile drug delivery of ketoprofen using hydrophilic and hydrophobic polymers. The drug delivery system was designed to deliver the drug at such a time when it could be most needful to patient of rheumatoid arthritis. The press coated tablets containing ketoprofen in the inner core was formulated with an outer shell by different weight ratio of hydrophobic polymer (micronized ethyl cellulose powder) and hydrophilic polymers (glycinemax husk or sodium alginate). The release profile of press coated tablet exhibited a lag time followed by burst release, in which outer shell ruptured into two halves. Authors also investigated factors influencing on lag time such as particle size and viscosity of ethyl cellulose, outer coating weight and paddle rpm. The surface morphology of the tablet was examined by a scanning electron microscopy. Differential scanning calorimeter and Fourier transformed infrared spectroscopy study showed compatibility between ketoprofen and coating material.
authors.affiliation: Department of Pharmaceutics and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur 425 405, Maharashtra, India.
authors.forename: Ashish Babulal
authors.initials: AB
authors.lastname: Rane
authors.forename: Surendra Ganeshlal
authors.initials: SG
authors.lastname: Gattani
authors.forename: Vinayak Dinkar
authors.initials: VD
authors.lastname: Kadam
authors.forename: Avinash Ramrao
authors.initials: AR
authors.lastname: Tekade
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D015195:Drug Design; D004355:Drug Stability; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007660:Ketoprofen / Q000138:chemical synthesis / Q000737:chemistry*; D008970:Molecular Weight; D010316:Particle Size; D011208:Powders / Q000737:chemistry; D013025:Glycine max / Q000737:chemistry*; D013499:Surface Properties; D013607:Tablets / Q000138:chemical synthesis* / Q000737:chemistry; D013997:Time Factors; D014783:Viscosity
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D011208:Powders; D013607:Tablets; C013517:ethyl cellulose; D020723:Glucuronic Acid; D002482:Cellulose; D007660:Ketoprofen