title: Sickle cell haemoglobin, thalassaemia and G-6-PD enzyme deficiency genes in Garasiya tribe inhabited malaria endemic areas of Sirohi District, Rajasthan (India).
abstract: Venous blood samples of 368 apparently healthy and unrelated adult individuals (both male and female) belonging to a primitive tribe, Garasiya inhabitating malaria hyperendemic areas of Sirohi district, Rajasthan (India) were investigated by standard and recommended techniques for evidence of erythrocyte genetic disorders; sickle cell haemoglobin, beta-thalassaemia syndromes and glucose-6-phosphate dehydrogenase (G-6-PD) enzyme deficiency (Gd). Sickle cell genes encountered in 23 (6.25%) Garasiya tribals. Of these, 22 (5.97%) showed heterozygous sickle cell gene(Hb-AS or trait) and one (0.27%) homozygous form (Hb-SS or sickle cell disease). beta-thalassaemia syndromes were observed in 30 (8.15%) subjects; 28 (7.60%) beta-thalassaemia traits (beta-thal.) and 2 (0.54%) HbS-thalassaemia (HbS-thal.). Gd was found in 56 (15.21%) subjects. Except these mutant genes no other erythrocyte abnormal genes were encountered in Garasiya tribe. A high incidence or prevalence of these red cell mutant genes in relation to malaria is discussed in the present communication.
authors.affiliation: Department of Zoology, Government Post Graduate College, Sirohi-307001, Rajasthan, India. choubisasl@yahoo.com
authors.forename: S L
authors.initials: SL
authors.lastname: Choubisa
mesh_terms: D000328:Adult; D000745:Anemia, Hemolytic, Congenital / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D000755:Anemia, Sickle Cell / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D004247:DNA / Q000097:blood / Q000235:genetics; D019353:Endemic Diseases; D005260:Female; D005796:Genes; D005820:Genetic Testing; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008288:Malaria / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D013789:Thalassemia / Q000097:blood / Q000208:ethnology / Q000235:genetics*
chemical_list: D004247:DNA