A large calcified retroperitoneal mass in a patient with chronic renal failure: liposarcoma with ossification.
Here we describe a 65-year-old Japanese man with chronic renal failure (CRF) and a large, dense, calcified abdominal mass. The patient had a history of proteinuria, which was diagnosed as focal glomerulosclerosis. This diagnosis was confirmed by renal biopsy in 2002, with worsening renal function by July 2005 when a large area of calcification was detected on abdominal radiography, which further increased in size on follow-up radiography in December 2006. The calcified mass was surgically resected and histopathologically diagnosed as myxoid-type liposarcoma composed of dedifferentiated, myxoid, and well-differentiated components with areas of osseous metaplasia. Soft tissue calcifications and ossifications are often benign, but malignant tumors should be considered when the calcified mass is retroperitoneal, occurs in a patient with no history of chronic infection, and is not located near a large joint or associated with administration of calcium carbonate or a vitamin D derivative.
Okuda
Itsuko
I
Department of Diagnostic Radiology, Toranomon Hospital, Minato-ku, Tokyo 105-8470, Japan. okudai-tora@umin.ac.jp
Ubara
Yoshifumi
Y
Okuda
Chikao
C
Fujii
Takeshi
T
Suwabe
Tatsuya
T
Kokubo
Takashi
T
Nakajima
Yasio
Y
Hashimoto
Masaji
M
D000368:Aged; D002114:Calcinosis / Q000175:diagnosis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000175:diagnosis*; D018208:Liposarcoma, Myxoid / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009999:Ossification, Heterotopic / Q000175:diagnosis*; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000175:diagnosis; D014057:Tomography, X-Ray Computed