title: MRI features in a canine model of ischemic stroke: correlation between lesion volume and neurobehavioral status during the subacute stage.
abstract: The purpose of this study was to evaluate the diagnostic value of magnetic resonance imaging (MRI) and assess the correlation between the volume of the ischemic lesion and neurobehavioral status during the subacute stage of ischemic stroke. Ischemic stroke was induced in 6 healthy laboratory beagles through permanent occlusion of the middle cerebral artery (MCAO). T2-weighted and fluid-attenuated inversion recovery (FLAIR) imaging, diffusion-weighted imaging (DWI), measurement of the apparent diffusion coefficient (ADC) ratio, and neurobehavioral evaluation were performed 3 times serially by using a 1.5-T MR system: before and 3 and 10 d after MCAO. Ischemic lesions demonstrated T2 hyperintensity, FLAIR hyperintensity, and DWI hyperintensity. The ADC ratio was decreased initially but then was increased at 10 d after MCAO. Ischemic lesion volumes on T2-weighted and FLAIR imaging were not significantly different from those on DWI. The lesion volume and neurobehavioral score showed strong correlation. Our results suggest that conventional MRI may be a reliable diagnostic tool during the subacute stage of canine ischemic stroke.
authors.affiliation: Department of Neurology, Dongguk University International Hospital, Goyang, South Korea.
authors.forename: Byeong-Teck
authors.initials: BT
authors.lastname: Kang
authors.forename: Dong-Pyo
authors.initials: DP
authors.lastname: Jang
authors.forename: Su-Hyun
authors.initials: SH
authors.lastname: Gu
authors.forename: Jong-Hwan
authors.initials: JH
authors.lastname: Lee
authors.forename: Dong-In
authors.initials: DI
authors.lastname: Jung
authors.forename: Chae-Young
authors.initials: CY
authors.lastname: Lim
authors.forename: Ha-Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Young-Bo
authors.initials: YB
authors.lastname: Kim
authors.forename: Hyung-Joong
authors.initials: HJ
authors.lastname: Kim
authors.forename: Eung-Je
authors.initials: EJ
authors.lastname: Woo
authors.forename: Zang-Hee
authors.initials: ZH
authors.lastname: Cho
authors.forename: Hee-Myung
authors.initials: HM
authors.lastname: Park
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D004195:Disease Models, Animal; D004285:Dogs; D017352:Echo-Planar Imaging / Q000379:methods; D005260:Female; D007089:Image Enhancement / Q000379:methods; D020244:Infarction, Middle Cerebral Artery / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011596:Psychomotor Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D011597:Psychomotor Performance / Q000502:physiology; D020521:Stroke / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology