Thermodynamic optimisation in drug discovery: a case study using carbonic anhydrase inhibitors.
Scott
Andrew D
AD
Pfizer Global Research & Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NU., UK. Andrew.d.scott@pfizer.com
Phillips
Chris
C
Alex
Alexander
A
Flocco
Maria
M
Bent
Andrew
A
Randall
Amy
A
O'Brien
Ronan
R
Damian
Luminita
L
Jones
Lyn H
LH
D000818:Animals; D001554:Benzene / Q000737:chemistry / Q000494:pharmacology; D002151:Calorimetry; D024402:Carbonic Anhydrase II / Q000378:metabolism*; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D002417:Cattle; D018360:Crystallography, X-Ray; D055808:Drug Discovery; D006801:Humans; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology; D013816:Thermodynamics; D017186:Titrimetry
D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D012710:Serum Albumin, Bovine; D024402:Carbonic Anhydrase II; D001554:Benzene