Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands.
The evaluation of a series of piperazinyl carbamates and ureas, designed on the basis of previously reported TRPV1 antagonists and FAAH inhibitors, led to the identification of some 'dual-action' compounds targeting both FAAH and TRPV1 or TRPA1 receptors.
Morera
Enrico
E
Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, 00185 Roma, Italy.
De Petrocellis
Luciano
L
Morera
Ludovica
L
Moriello
Aniello Schiano
AS
Ligresti
Alessia
A
Nalli
Marianna
M
Woodward
David F
DF
Di Marzo
Vincenzo
V
Ortar
Giorgio
G
D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D008024:Ligands; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D050051:Transient Receptor Potential Channels / Q000037:antagonists & inhibitors*; D014508:Urea / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000099252:Fatty Acid Amide Hydrolases
D000581:Amidohydrolases; D002219:Carbamates; D008024:Ligands; D050051:Transient Receptor Potential Channels; D014508:Urea; D000099252:Fatty Acid Amide Hydrolases