Evaluation of a cognitive behaviourally oriented service for relapse prevention in schizophrenia.
OBJECTIVE
There is little work demonstrating the effectiveness of cognitive behaviourally oriented interventions in routine service settings. This pragmatic trial is designed to test the impact of a group treatment service on relapse rates under the conditions of routine health care.


METHODS
A total of 169 schizophrenia patients were randomly allocated either to a comprehensive cognitive behaviourally oriented service (CBOS) or to treatment as usual (TAU). The primary outcome is the time until the first relapse after discharge from hospital. Relapse was defined as an increase in positive or negative symptoms as assessed with the Positive and Negative Syndrome Scale. Survival analysis has been conducted up to the 6-month assessment.


RESULTS
The mean time to relapse after discharge from hospital in the CBOS group was significantly longer than in the TAU group (log rank test, P = 0.033). This was due to less exacerbations regarding negative symptoms in the CBOS condition (log rank test, P = 0.014). The number of social contacts was improved in the CBOS group only.


CONCLUSIONS
The CBOS intervention appears to be beneficial in reducing early negative symptom exacerbations.
Klingberg
S
S
Department of Psychiatry and Psychotherapy, University of Tuebingen, Germany. stefan.klingberg@med.uni-tuebingen.de <stefan.klingberg@med.uni-tuebingen.de>
Wittorf
A
A
Fischer
A
A
Jakob-Deters
K
K
Buchkremer
G
G
Wiedemann
G
G
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D005858:Germany; D006778:Hospitals, Psychiatric; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000523:psychology / Q000534:rehabilitation*; D012559:Schizophrenia / Q000534:rehabilitation*; D012565:Schizophrenic Psychology; D055502:Secondary Prevention; D016896:Treatment Outcome; D055815:Young Adult
D014150:Antipsychotic Agents