title: Intraductal papillary mucinous neoplasms of the pancreas with multifocal involvement of branch ducts.
abstract: BACKGROUND
  The appropriate management of patients with branch-duct intraductal papillary mucinous neoplasm (BD-IPMN) with multiple involvements of branch ducts (multifocal BD-IPMN) remains challenging.
  
  
  METHODS
  Our database of patients affected by IPMN was queried to identify patients with a clinicoradiologic or a pathologic diagnosis of multifocal BD-IPMN between January 1990 and December 2006.
  
  
  RESULTS
  One hundred thirty-one patients (52 male and 79 female; median age 67 years) had a clinicoradiologic or a histopathologic diagnosis of multifocal BD-IPMN. Ten patients (7.6%) underwent surgery. After a median follow-up of 40 months (range 12 to 127) all the 121 patients conservatively managed are alive, and none underwent surgery during follow-up. One patient with invasive carcinoma developed hepatic metastases and died of disease 88 months after surgery.
  
  
  CONCLUSIONS
  Patients with branch-side IPMN can be conservatively managed, but when multifocality is present follow-up may be problematic because of the number of lesions to be evaluated. The nonoperative management of well-selected patients with BD-IPMN, even in the multifocal setting, seems to be safe and reliable.
authors.affiliation: Department of Surgery, University of Verona, Verona, Italy. roberto.salvia@medicina.univr.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Salvia
authors.forename: Stefano
authors.initials: S
authors.lastname: Partelli
authors.forename: Stefano
authors.initials: S
authors.lastname: Crippa
authors.forename: Luca
authors.initials: L
authors.lastname: Landoni
authors.forename: Paola
authors.initials: P
authors.lastname: Capelli
authors.forename: Riccardo
authors.initials: R
authors.lastname: Manfredi
authors.forename: Claudio
authors.initials: C
authors.lastname: Bassi
authors.forename: Paolo
authors.initials: P
authors.lastname: Pederzoli
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery; D021441:Carcinoma, Pancreatic Ductal / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010183:Pancreatic Ducts / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D011859:Radiography