Polymorphism of tumor protein p53 codon 72 showed no association with oral lichen planus in Shiraz, Iran.
BACKGROUND
Oral lichen planus (OLP) is a chronic relapsing inflammatory disease involving T-lymphocyte aggression targeted to the basal layer of the oral mucosa. The tumor suppressor tumor protein p53 (TP53), located on chromosome 17, has been involved in various malignancies.


OBJECTIVE
This study was undertaken to investigate the association of p53 codon 72 polymorphism with OLP in Southern Iranian patients.


METHODS
Twenty-five patients with lichen planus and 93 healthy blood donors as control group were recruited. DNA from peripheral blood mononuclear cells was extracted and amplified using allele-specific polymerase chain reaction.


RESULTS
The frequency of homozygotic arginine (Arg) at codon 72 was 44% in the patients and 37.6% in the controls; for homozygotic proline (Pro), it was 24% and 15.15%, respectively, and for heterozygotic arginine/proline, it was 32% and 47.3%, respectively.


CONCLUSIONS
The polymorphism in codon 72 of the TP53 gene was not associated with the OLP in Iranian patients.
Ghabanchi
Jannan
J
Department of Oral Medicine, Dental School, Shiraz University of Medical Sciences, Shiraz, Fars, Iran.
Fattahi
Mohmmad Javad
MJ
Mardani
Maryam
M
Tadbir
Azadeh Andisheh
AA
Paydar
Abass Ali
AA
D000328:Adult; D001120:Arginine / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007492:Iran; D017676:Lichen Planus, Oral / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011392:Proline / Q000235:genetics; D017422:Sequence Analysis, DNA; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D016159:Tumor Suppressor Protein p53; D001120:Arginine; D011392:Proline