[Particularities of arginase and NO-synthase pathways of L-arginine metabolism in leucocytes of peripheral blood of rats in conditions of chronic x-ray irradiation].
Arginine takes part in many metabolic cell processes. It is not only involved in the dynamic cycle of interconversion with prolin and glutamine but also serves as a precursor for protein, nitric oxide, creatine, polyamines, agmatine and urea synthesis. Particularities of arginase and NO-synthase pathways of L-arginine conversion under the X-ray radiation in the leucocytes-radiosensitive cells of peripheral blood, under the per os administration of L-arginine and L-NAME (NG-nitro-L-arginine methyl ester) to rats were detected. It was shown that both L-arginine (arginase and NO-synthase main substrate) and L-NAME (nonspecific inhibitor of NO-synthase) had a positive correct influence on the organism in case of decreasing of NO overproduction under the X-ray radiation.
Peretiatko
Iu V
IuV
Sybirna
N O
NO
D000818:Animals; D001119:Arginase / Q000378:metabolism*; D001120:Arginine / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D007962:Leukocytes / Q000201:enzymology / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013379:Substrate Specificity; D013997:Time Factors; D014965:X-Rays
D001120:Arginine; D019001:Nitric Oxide Synthase; D001119:Arginase; D019331:NG-Nitroarginine Methyl Ester