title: [EPR study of the influence of hypoxia on nitric oxide formation in the blood of Krushinskii-Molodkina rats].
abstract: The influence of hypoxia on nitric oxide formation in the blood of Krushinskii-Molodkina rats has been studied by electron paramagnetic resonance. It was found that nitric oxide synthesis in Krushinskii-Molodkina rats is increased compared with that in Wistar rats. A significant enhancement of the EPR signal of Hb-NO complexes in the animal blood was observed after hypoxia simulating the altitude of 5000 m above the sea level, in particular in the presence of sodium nitrite and the NO-synthase inhibitor L-nitroarginine. It was assumed that NO synthesis and nitro-/nitrite- reductase systems are activated under hypoxic conditions.
authors.forename: L M
authors.initials: LM
authors.lastname: Baĭder
authors.forename: V P
authors.initials: VP
authors.lastname: Reutov
authors.forename: A L
authors.initials: AL
authors.lastname: Krushinskiĭ
authors.forename: V S
authors.initials: VS
authors.lastname: Kuzenkov
authors.forename: E G
authors.initials: EG
authors.lastname: Sorokina
authors.forename: V B
authors.initials: VB
authors.lastname: Koshelev
authors.forename: O E
authors.initials: OE
authors.lastname: Fadiukov
authors.forename: T T
authors.initials: TT
authors.lastname: Zhymabaeva
authors.forename: T A
authors.initials: TA
authors.lastname: Lozinova
authors.forename: L Kh
authors.initials: LKh
authors.lastname: Komissarova
authors.forename: V G
authors.initials: VG
authors.lastname: Pinelis
authors.forename: N S
authors.initials: NS
authors.lastname: Kositsin
authors.forename: Z V
authors.initials: ZV
authors.lastname: Kuropteva
mesh_terms: D000818:Animals; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D006454:Hemoglobins / Q000032:analysis / Q000378:metabolism*; D000860:Hypoxia / Q000097:blood*; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
chemical_list: D006454:Hemoglobins; D009569:Nitric Oxide