title: Simulating the wrinkling and aging of skin with a multi-layer finite element model.
abstract: One of the outward signs of the aging process of human skin is the increased appearance of wrinkles on its surface. Clinical studies show that the increased frequency of wrinkles with age may be attributed to changes in the composition of the various layers of skin, leading to a change in mechanical properties. A parameter study was performed on a previously proposed multi-layer finite element model of skin. A region of skin was subject to an in-plane compression, resulting in wrinkling. A number of physical properties of the skin model were changed and the effects these changes had on the size of the subsequent wrinkles were measured. Reducing the moisture content of the stratum corneum by 11% produces wrinkles 25-85% larger. Increasing the dermal collagen fibre density by 67%, results in wrinkles, which are 25-50% larger. A reduction and change in the pre-stress distribution in the skin model, which represents the natural tension and relaxed skin tension lines in real skin, also influences the wrinkle height in a similar manner to real aging skin. Typically, there can be up to a 100% increase in the height of wrinkles as skin ages. This model would be of benefit in the development of cosmetic moisturisers and plastic-surgery techniques to reduce the appearance of aging.
authors.affiliation: Bioengineering Institute, University of Auckland, Level 6, 70 Symonds St, Auckland, New Zealand. c.flynn@auckland.ac.nz
authors.forename: Cormac
authors.initials: C
authors.lastname: Flynn
authors.forename: Brendan A O
authors.initials: BA
authors.lastname: McCormack
mesh_terms: D000375:Aging / Q000502:physiology*; D016880:Anisotropy; D003198:Computer Simulation; D055119:Elastic Modulus / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D015595:Skin Aging / Q000502:physiology*; D013314:Stress, Mechanical; D014783:Viscosity