title: Quiet gene circuit more fragile than its noisy peer.
abstract: Why is a particular architecture for a pathway chosen over seemingly equivalent alternatives? Cağatay et al. (2009) use a synthetic biology approach to show that fluctuations--or noise--in protein levels may play a key role in determining which network design is selected during evolution.
authors.affiliation: Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Tobias
authors.initials: T
authors.lastname: Bollenbach
authors.forename: Roy
authors.initials: R
authors.lastname: Kishony
mesh_terms: D001412:Bacillus subtilis / Q000235:genetics / Q000502:physiology*; D005075:Biological Evolution; D053263:Gene Regulatory Networks; D008954:Models, Biological