Efficient synthesis of 3-arylphthalides using palladium-catalyzed arylation of aldehydes with organoboronic acids.
The synthesis of 3-arylphthalides via palladium-catalyzed arylation of aldehydes with organoboronic acids was achieved using the thioether-imidazolinium carbene ligand in good to excellent yields and was carried out using 1.0 mol % of the catalyst with high substrate tolerance.
Kuriyama
Masami
M
Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan. mkuriyam@nagasaki-u.ac.jp
Ishiyama
Natsuki
N
Shimazawa
Rumiko
R
Shirai
Ryuichi
R
Onomura
Osamu
O
D000447:Aldehydes / Q000737:chemistry*; D001572:Benzofurans / Q000138:chemical synthesis*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D010165:Palladium
D000447:Aldehydes; D001572:Benzofurans; D001897:Boronic Acids; D006841:Hydrocarbons, Aromatic; D010165:Palladium; C082022:phthalide