title: The relevance of a hypoxic tumour microenvironment in prostate cancer.
abstract: Research into the hypoxic tumour microenvironment is accelerating and the reversal of hypoxia is increasingly being suggested as a mechanism for improving cancer treatment. Recent studies have suggested that hypoxia is also a feature in prostate cancer and is associated with a poor prognosis. Hypoxia has been shown to cause radio-resistance and hence hamper one of the major treatments for prostate cancer. However, unlike other solid tumours, such as cervical and head-and-neck cancer, there are inconsistencies and unanswered questions about the relevance of hypoxia in prostate cancer. This review outlines the role of low-oxygen conditions in prostate cancer and the areas where further studies are required.
authors.affiliation: Prostate Research Group, Department of Urology, University of Edinburgh, Western General Hospital, Edinburgh, UK. grant.stewart@ed.ac.uk
authors.forename: Grant D
authors.initials: GD
authors.lastname: Stewart
authors.forename: James A
authors.initials: JA
authors.lastname: Ross
authors.forename: Duncan B
authors.initials: DB
authors.lastname: McLaren
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Parker
authors.forename: Fouad K
authors.initials: FK
authors.lastname: Habib
authors.forename: Antony C P
authors.initials: AC
authors.lastname: Riddick
mesh_terms: D015687:Cell Hypoxia; D049109:Cell Proliferation; D002470:Cell Survival; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D008297:Male; D011471:Prostatic Neoplasms / Q000098:blood supply / Q000473:pathology* / Q000628:therapy; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D051793:Hypoxia-Inducible Factor 1; D042461:Vascular Endothelial Growth Factor A