CD19-positive acute myeloblastic leukemia with trisomy 21 as a sole acquired karyotypic abnormality.
We report that a 63-year-old Chinese female had acute myeloblastic leukemia (AML) in which trisomy 21 (+21) was found as the sole acquired karyotypic abnormality. The blasts were positive for myeloperoxidase, and the immunophenotype was positive for cluster of differentiation 19 (CD19), CD33, CD34, and human leukocyte antigens (HLA)-DR. The chromosomal analysis of bone marrow showed 47,XX,+21[2]/46,XX[18]. Fluorescent in situ hybridization (FISH) showed that three copies of AML1 were situated in separate chromosomes, and that t(8;21) was negative. The patient did not have any features of Down syndrome. A diagnosis of CD19-positive AML-M5 was established with trisomy 21 as a sole acquired karyotypic abnormality. The patient did not respond well to chemotherapy and died three months after the diagnosis. This is the first reported case of CD19-positive AML with trisomy 21 as the sole cytogenetic abnormality. The possible prognostic significance of the finding in AML with +21 as the sole acquired karyotypic abnormality was discussed.
Wang
Hua-feng
HF
Department of Hematology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Cheng
Yi-zhi
YZ
Wang
Huan-ping
HP
Chen
Zhi-mei
ZM
Lou
Ji-yu
JY
Jin
Jie
J
D015703:Antigens, CD / Q000096:biosynthesis; D018941:Antigens, CD19 / Q000096:biosynthesis*; D018952:Antigens, CD34 / Q000096:biosynthesis; D015214:Antigens, Differentiation, Myelomonocytic / Q000096:biosynthesis; D001854:Bone Marrow Cells / Q000378:metabolism; D004314:Down Syndrome / Q000150:complications / Q000235:genetics*; D005260:Female; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000235:genetics*; D008875:Middle Aged; D009195:Peroxidase / Q000378:metabolism; D063268:Sialic Acid Binding Ig-like Lectin 3; D014178:Translocation, Genetic
D015703:Antigens, CD; D018941:Antigens, CD19; D018952:Antigens, CD34; D015214:Antigens, Differentiation, Myelomonocytic; C571163:CD33 protein, human; D006684:HLA-DR Antigens; D063268:Sialic Acid Binding Ig-like Lectin 3; D009195:Peroxidase