Effect of topical 1% tropicamide on Schirmer tear test results in clinically normal horses.
OBJECTIVE
To observe the effect of topical 1% tropicamide on equine tear production as measured by Schirmer I tear test.


METHODS
Fourteen adult horses received one drop of 1% tropicamide ophthalmic solution in one eye and the opposite eye served as the control. The tear production in both eyes was tested at 1, 2, 4, 6, and 24 h after 1% tropicamide administration.


RESULTS
Measurements made 1 h after treatment revealed a significant reduction in Schirmer tear test values in tropicamide treated eyes (P = 0.002). The observed decrease in tear production was maintained up to 4 h after treatment (P = 0.002). Although tropicamide-induced decrease in STT values was observed in the treated eyes, the contralateral eyes did not show significant changes in Schirmer tear test results.


CONCLUSIONS
Single dose of topical 1% tropicamide resulted in statistically significant reduction in Schirmer tear test values in clinically normal horses.
Selk Ghaffari
Masoud
M
Department of Clinical Studies, School of Veterinary Medicine, Islamic Azad University-Karaj Branch, Karaj, Iran. selkghaffari@gmail.com
Sabzevari
Amin
A
Radmehr
Behrad
B
D000818:Animals; D006736:Horses / Q000502:physiology*; D007765:Lacrimal Apparatus / Q000187:drug effects* / Q000502:physiology; D009184:Mydriatics / Q000008:administration & dosage / Q000494:pharmacology; D009883:Ophthalmic Solutions; D013666:Tears / Q000502:physiology*; D014331:Tropicamide / Q000008:administration & dosage* / Q000494:pharmacology*
D009184:Mydriatics; D009883:Ophthalmic Solutions; D014331:Tropicamide