title: Intermolecular decarboxylative direct C-3 arylation of indoles with benzoic acids.
abstract: A palladium catalyzed C-H activation of indoles and a silver catalyzed decarboxylative C-C activation of ortho substituted benzoic acids are synergistically combined to synthesize indoles arylated exclusively in the C-3 position. This novel decarboxylative C-H arylation methodology is compatible with electron-donating and -withdrawing substituents in both coupling partners.
authors.affiliation: Queen Mary University of London, School of Biological and Chemical Sciences, Joseph Priestley Building, Mile End Road, London E1 4NS, United Kingdom.
authors.forename: Josep
authors.initials: J
authors.lastname: Cornella
authors.forename: Pengfei
authors.initials: P
authors.lastname: Lu
authors.forename: Igor
authors.initials: I
authors.lastname: Larrosa
mesh_terms: D001565:Benzoates / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
chemical_list: D001565:Benzoates; D007211:Indoles; D010165:Palladium