Multicentric Castleman's disease & HIV infection.
We report the case of a 35 year patient from Nigeria who presented with fever and splenomegaly. The initial diagnosis was Salmonellosis. However, relapsing symptoms lead to a re-evaluation and ultimately a diagnosis of Multicentric Castleman's Disease (MCD). There is no gold standard treatment but our patient responded to Rituximab and Highly active anti-retroviral therapy. MCD is a rare, aggressive disease that should be considered in a HIV positive patient presenting with fever and significant lymphadenopathy.
Cotter
A
A
Department Infectious Diseases, Mater Misericordiae University Hospital, Eccles St., Dublin 7 and University College Dublin, School of Medicine & Medical Sciences, Dublin. aoife@aoifecotter.com
Lambert
J
J
O'Gorman
P
P
D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D023241:Antiretroviral Therapy, Highly Active; D005871:Castleman Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D002939:Ciprofloxacin / Q000627:therapeutic use; D019288:Herpesvirus 8, Human; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D000069283:Rituximab; D013163:Splenomegaly
D000890:Anti-Infective Agents; D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D007155:Immunologic Factors; D000069283:Rituximab; D002939:Ciprofloxacin