Sequence Fourier analysis of a specific protein-DNA (RNA) interaction; an intermolecular frequency symmetry.
Here, we first report that a specific protein-DNA (RNA) interaction between p53 protein and divergent I kappa B kinase interacting protein (IKIP)-Apaf1 DNA promoter region, and between poliovirus 3CD protein and the 5' terminal region of the RNA sequence can be successfully elucidated with a sequence Fourier analysis, alike various specific protein-protein interactions described previously. Based on these, the intermolecular frequency symmetry would be evolutionarily conserved in a specific interaction of the bioactive structure of various long-chain sequences. In addition, the symmetry is fairly sensitive to a substitution (or a point mutation) on the sequence.
Numao
Naganori
N
BioFrontier Institute Inc., 5-4-21 Nishi-Hashimoto, Sagamihara, Kanagawa 229-1131, Japan. kamimoto@kanagawa-iri.go.jp
Kamimoto
Yoshihito
Y
D000086042:3C Viral Proteases; D003546:Cysteine Endopeptidases / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D005583:Fourier Analysis; D051550:I-kappa B Kinase / Q000737:chemistry*; D011485:Protein Binding; D012313:RNA / Q000737:chemistry*; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry*; D014764:Viral Proteins / Q000737:chemistry*
D016159:Tumor Suppressor Protein p53; D014764:Viral Proteins; D012313:RNA; D004247:DNA; D051550:I-kappa B Kinase; D003546:Cysteine Endopeptidases; D000086042:3C Viral Proteases