title: Topiramate overdose: a case report of a patient with extremely high topiramate serum concentrations and nonconvulsive status epilepticus.
abstract: We report the case of a 21-year-old man with idiopathic generalized epilepsy who ingested about 8,000 mg of topiramate (TPM) in a suicide attempt. On admission to the hospital he had a nonconvulsive status epilepticus and received 4 mg lorazepam i.v. He recovered rapidly despite an initial TPM concentration of 144.6 microg/ml. To our knowledge, this is the first report of a patient who survived such a high TPM concentration. The case indicates that nonconvulsive status epilepticus could be a manifestation of TPM intoxication.
authors.affiliation: Bethel Epilepsy Centre, Department of General Epileptology, Bielefeld, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Brandt
authors.forename: Heike
authors.initials: H
authors.lastname: Elsner
authors.forename: Nora
authors.initials: N
authors.lastname: Füratsch
authors.forename: Matthias
authors.initials: M
authors.lastname: Hoppe
authors.forename: Esther
authors.initials: E
authors.lastname: Nieder
authors.forename: Bernhard
authors.initials: B
authors.lastname: Rambeck
authors.forename: Alois
authors.initials: A
authors.lastname: Ebner
authors.forename: Theodor W
authors.initials: TW
authors.lastname: May
mesh_terms: D062787:Drug Overdose; D005632:Fructose / Q000031:analogs & derivatives* / Q000097:blood / Q000506:poisoning; D006801:Humans; D008297:Male; D013226:Status Epilepticus / Q000097:blood* / Q000139:chemically induced / Q000175:diagnosis; D013406:Suicide, Attempted; D000077236:Topiramate; D055815:Young Adult
chemical_list: D000077236:Topiramate; D005632:Fructose