[Positron emission tomography and evaluation of response to targeted therapies].
The development of new-targeted therapies has highlighted the need to adapt the criteria used so far for radiological assessment of tumor response, but also the search for new criteria for a more appropriate evaluation. Nuclear medicine, and especially positron emission tomography (PET) offers a variety of functional imaging for early assessment of tumor response to targeted therapies. In this paper, we first describe data in the literature on PET technique with fluorodeoxyglucose (FDG) in this indication and the associated new molecules. The second part discusses the new positron-emitting tracers that are potentially interesting for the evaluation of action or efficacy of these new molecules (imaging "targeted" to specific metabolic pathways, cell proliferation, hypoxia, angiogenesis, receptors, etc.).
Gauthier
Hélène
H
Service de médecine nucléaire, centre Oscar-Lambret, 3, avenue Combemale, BP 307, 59020 Lille cedex, France. h-Gauthier@o-lambret.fr
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis; D001549:Benzamides; D015687:Cell Hypoxia; D049109:Cell Proliferation; D002794:Choline / Q000378:metabolism; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D046152:Gastrointestinal Stromal Tumors / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D000068877:Imatinib Mesylate; D050356:Lipid Metabolism; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging; D010879:Piperazines / Q000627:therapeutic use; D049268:Positron-Emission Tomography / Q000379:methods*; D014176:Protein Biosynthesis; D011494:Protein Kinases; D011743:Pyrimidines / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D058570:TOR Serine-Threonine Kinases
D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D019275:Radiopharmaceuticals; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D019788:Fluorodeoxyglucose F18; D000068877:Imatinib Mesylate; D011494:Protein Kinases; C546842:MTOR protein, human; D066246:ErbB Receptors; D058570:TOR Serine-Threonine Kinases; D002794:Choline