C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population.
BACKGROUND
We studied the association of C-reactive protein (CRP), gamma-glutamyltransferase (GGT) and type 2 diabetes in Chinese.


METHODS
A population-based cross-sectional study.


RESULTS
CRP and GGT levels were significantly higher in participants with diabetes than in those without (P<0.001). Higher CRP levels were positively associated with prevalent type 2 diabetes after adjustment for age, sex, smoking, alcohol consumption, physical activity, family history of diabetes, body mass index, waist circumference, waist/hip ratio, education, systolic blood pressure, triglycerides, high density lipoprotein cholesterol, use of antihypertensive drugs, aspirin and lipid-lowering agents, with multivariable odds ratios (OR) of 1.55 (95% confidence interval (CI), 1.05-2.27, P trend=0.005, comparing quartile 4 to quartile 1). However, after further adjustment for GGT, the association was completely attenuated (fourth quartile OR 1.23, 95% CI, 0.83-1.82, P trend=0.127). Moreover, the association of CRP and prevalent type 2 diabetes was stronger in subjects with GGT values above the median than in those with GGT values below the median. Increasing serum GGT quartiles were positively associated with prevalent type 2 diabetes after adjustment for potential confounding variables (P for trend <0.001).


CONCLUSIONS
CRP may not be an independent risk factor for type 2 diabetes, at least in Chinese people.
Wen
Jiangping
J
Department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Liang
Yuanbo
Y
Wang
Fenghua
F
Sun
Lanping
L
Guo
Yongjun
Y
Duan
Xinrong
X
Liu
Xiangyi
X
Wong
Tien Yin
TY
Lu
Xinxin
X
Wang
Ningli
N
D000328:Adult; D044466:Asian People; D002097:C-Reactive Protein / Q000378:metabolism*; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000201:enzymology / Q000453:epidemiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors; D005723:gamma-Glutamyltransferase / Q000097:blood*
D002097:C-Reactive Protein; D005723:gamma-Glutamyltransferase