Hypoglycemic polysaccharides from the tuberous root of Liriope spicata.
Previous studies showed that the water extract and crude polysaccharides from the tuberous root of Liriope spicata var. prolifera showed high hypoglycemic and hypolipidemic activities. In the present study, two new water-soluble polysaccharides, named LSP1 and LSP2, were isolated from the active crude polysaccharides by DEAE-cellulose 52 and AB-8 macroporous resin chromatography and tested for their hypoglycemic effects. On the basis of the chemical and physical data obtained, LSP1 and LSP2 are two fructans with the molecular weights 3.20 and 4.29 kDa, respectively, which both have a backbone structure of beta-(1-->2)-fructosyl residues that branches at O-6 with fructosyl residues and terminates with a glucosyl residue and a fructosyl residue. Preliminary activity tests revealed that both LSP1 and LSP2 caused a significant decrease of the fasting blood glucose (FBG) and a significant improvement on glucose tolerance in type 2 diabetic mice. These results suggest that LSP1 and LSP2 show high potential to be explored as natural oral hypoglycemic agents.
Chen
Xianghong
X
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Hangkong Road 13#, Wuhan 430030, People's Republic of China.
Liu
Yihui
Y
Bai
Xue
X
Wen
Li
L
Fang
Jinbo
J
Ye
Mao
M
Chen
Jiachun
J
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031424:Liriope Plant / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; C545396:LSP1 polysaccharide; C545395:LSP2 polysaccharide; D011134:Polysaccharides