title: Variable expression of soluble fms-like tyrosine kinase 1 in patients at high risk for preeclampsia.
abstract: OBJECTIVE
  To explore angiogenic factor differences in preeclamptic patients according to the absence or presence of underlying vascular disease.
  
  
  METHODS
  We prospectively compared serum soluble fms-like tyrosine kinase 1 (sFlt1), soluble endoglin, and placental growth factor (PlGF) from 41 normal-risk and 32 high-risk (preexisting conditions) subjects at serial gestational ages.
  
  
  RESULTS
  Median sFlt1 was lower at delivery in preeclamptic patients with underlying chronic hypertension and/or chronic proteinuria (5115 pg/ml) compared with normal risk preeclamptic patients (16375 pg/ml). PlGF was consistently low in patients who developed preeclampsia.
  
  
  CONCLUSIONS
  Effects of sFlt1 may be contextual, varying according to the health or disease state of vascular endothelium.
authors.affiliation: Department of Obstetrics and Gynecology, Santa Clara Valley Medical Center, 751 S. Bascom Ave., San Jose, CA 95128, USA. dwyerbk@gmail.com
authors.forename: Bonnie K
authors.initials: BK
authors.lastname: Dwyer
authors.forename: Sacha
authors.initials: S
authors.lastname: Krieg
authors.forename: Raymond
authors.initials: R
authors.lastname: Balise
authors.forename: Ian R
authors.initials: IR
authors.lastname: Carroll
authors.forename: Jane
authors.initials: J
authors.lastname: Chueh
authors.forename: Nihar
authors.initials: N
authors.lastname: Nayak
authors.forename: Maurice
authors.initials: M
authors.lastname: Druzin
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000097:blood / Q000378:metabolism; D016022:Case-Control Studies; D000071063:Endoglin; D005260:Female; D005865:Gestational Age; D006801:Humans; D008137:Longitudinal Studies; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000097:blood / Q000378:metabolism; D012307:Risk Factors; D012995:Solubility; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D011956:Receptors, Cell Surface; D000072483:Placenta Growth Factor; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1