title: Metabolic syndrome is associated with intracranial large artery disease among ethnic Chinese patients with stroke.
abstract: BACKGROUND
  The association of metabolic syndrome (MetS) and intracranial large artery disease (ICLAD) has been described, but only in cohorts of ethnic Korean patients with stroke. We investigated the relationship of MetS and ICLAD among ethnic Chinese patients.
  
  
  METHODS
  This is a prospective study of consecutive ethnic Chinese patients with acute ischemic stroke living in Singapore. ICLAD was diagnosed on transcranial color-coded Doppler or magnetic resonance angiography.
  
  
  RESULTS
  Among the 135 patients studied, the frequency of MetS was higher among patients with ICLAD (39% v 16%, P = .003). This association was independent of age, hypertension, and diabetes (P = .003), and individual MetS criteria (P = .004). The prevalence of ICLAD positively correlated with the number of MetS criteria fulfilled (P = .021).
  
  
  CONCLUSIONS
  Our findings of an association between MetS and ICLAD among ethnic Chinese patients with stroke concur with findings among ethnic Korean patients. This validation provides a basis for further investigation into the pathophysiologic link between MetS and ICLAD.
authors.affiliation: Department of Neurology, Singapore General Hospital Campus, National Neuroscience Institute, Singapore. gnrdsd@sgh.com.sg
authors.forename: Deidre Anne
authors.initials: DA
authors.lastname: De Silva
authors.forename: Fung-Peng
authors.initials: FP
authors.lastname: Woon
authors.forename: Moi-Pin
authors.initials: MP
authors.lastname: Lee
authors.forename: Christopher Li-Hsian
authors.initials: CL
authors.lastname: Chen
authors.forename: Hui-Meng
authors.initials: HM
authors.lastname: Chang
authors.forename: Meng-Cheong
authors.initials: MC
authors.lastname: Wong
mesh_terms: D000368:Aged; D044466:Asian People; D002545:Brain Ischemia / Q000208:ethnology* / Q000209:etiology; D002533:Cerebral Angiography; D002681:China / Q000208:ethnology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D020765:Intracranial Arterial Diseases / Q000150:complications / Q000175:diagnosis / Q000208:ethnology*; D018810:Magnetic Resonance Angiography; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000208:ethnology*; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012846:Singapore / Q000453:epidemiology; D020521:Stroke / Q000208:ethnology* / Q000209:etiology; D018615:Ultrasonography, Doppler, Color; D017585:Ultrasonography, Doppler, Transcranial