title: [Association between the serum HBV DNA loads normalized to hepatic parenchyma cell volume and the liver histopathologic inflammation gradings in the immune clearance phase].
abstract: OBJECTIVE
  To investigate the relationship between the serum HBV DNA loads normalized to hepatic parenchyma cell volume and the liver histopathologic inflammation gradings in the immune clearance phase during the natural history of hepatitis B.
  
  
  METHODS
  Serum HBV DNA loads were detected by fluorescence polymerase chain reaction and normalized to hepatic parenchyma cell volume. The association between normalized HBV DNA loads and liver inflammation histopathologic grade were analyzed.
  
  
  RESULTS
  The serum HBV DNA loads in patients with liver inflammation histopathologic grading 1, 2, 3 and 4 were 8.20*10(5)+/-9.11*10, 1.36*10(6)+/-5.96*10, 8.12*10(5)+/-8.01*10 and 2.08*10(6)+/-3.69*10 copies/ml, respectively (P more than 0.05). But the serum HBV DNA loads normalized to hepatic parenchyma cell volume in their located fibrosis stage were 9.24*10(8)+/-935, 5.33*10(9)+/-756, 1.06*10(10)+/-1770 and 3.31*10(11)+/-518 copies/ml, respectively (P less than 0.05).
  
  
  CONCLUSIONS
  The serum HBV DNA load normalized to hepatic parenchyma cell volume in patients with different fibrosis stages is associated with liver histopathologic inflammation gradings.
authors.affiliation: Department of Infectious Diseases, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Li
authors.forename: Shi-Bin
authors.initials: SB
authors.lastname: Xie
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Zang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zang
authors.forename: Zhi-Xin
authors.initials: ZX
authors.lastname: Zhao
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Ke
authors.forename: Zhi-Liang
authors.initials: ZL
authors.lastname: Gao
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D004279:DNA, Viral / Q000097:blood*; D001330:Electronic Data Processing; D005260:Female; D006515:Hepatitis B virus / Q000276:immunology / Q000302:isolation & purification*; D019694:Hepatitis B, Chronic / Q000097:blood / Q000276:immunology / Q000473:pathology* / Q000821:virology*; D006801:Humans; D007249:Inflammation / Q000473:pathology / Q000821:virology; D008103:Liver Cirrhosis / Q000473:pathology* / Q000821:virology; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods; D012720:Severity of Illness Index; D019562:Viral Load; D055815:Young Adult
chemical_list: D004279:DNA, Viral