Glycogen synthase kinase 3 in the world of cell migration.
Glycogen synthase kinase 3 (GSK3) is one of the few master switch kinases that regulate many aspects of cell functions. Recent studies on cell polarization and migration have shown that GSK3 is also essential for proper regulation of these processes. GSK3 influences cell migration as one of the regulators of the spatiotemporally controlled dynamics of the actin cytoskeleton, microtubules, and cell-to-matrix adhesions. In this mini-review, the effects of GSK3 on these three aspects of cell migration will be discussed.
Sun
Tong
T
Department of Biological Sciences, Florida International University, Miami, FL 33199, USA.
Rodriguez
Marbelys
M
Kim
Leung
L
D000818:Animals; D002450:Cell Communication / Q000502:physiology; D002465:Cell Movement / Q000235:genetics / Q000502:physiology*; D003599:Cytoskeleton / Q000235:genetics / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism / Q000502:physiology; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008870:Microtubules / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological
D038362:Glycogen Synthase Kinase 3