Epidemiology and associated factors for nosocomial methicillin-resistant Staphylococcus aureus infection in a tertiary-care hospital.
We analysed nosocomial MRSA cases between January 2004 and December 2006 in a retrospective case-control study in a 250-bed tertiary-care teaching hospital. During the study period, 265 nosocomial Staphylococcus aureus infections were identified in 231 patients. There was a significant increase in methicillin resistance in isolates (MRSA) from these infections with frequencies for 2004 of 39/88 (44.3%), 2005 (62/80, 77.5%), and 2006 (75/97, 77.3%) (P<0.001). Multivariate analysis showed that associated factors for nosocomial MRSA infection were prolonged hospitalization (OR 3.982, 95% CI 2.235-7.094, P<0.001), mechanical ventilation (OR 3.052, 95% CI 1.666-5.590, P<0.001), surgical operation (OR 2.032, 95% CI 1.102-3.748, P=0.023), and male sex (OR 2.000, 95% CI 1.081-3.699, P=0.027). The determination of associated factors for methicillin resistance in nosocomial S. aureus infections in hospitals will play an important role in efforts to reduce MRSA infection rates.
Sacar
S
S
Pamukkale University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Kinikli, 20070 Denizli, Turkey.
Sayin Kutlu
S
S
Turgut
H
H
Cevahir
N
N
Hircin Cenger
D
D
Tekin
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006761:Hospitals; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007902:Length of Stay; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D008875:Middle Aged; D012121:Respiration, Artificial; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013514:Surgical Procedures, Operative; D055815:Young Adult