Comparison of recovery from anesthesia with isoflurane, sevoflurane, or desflurane in healthy dogs.
OBJECTIVE
To determine the quality and speed of recovery from anesthesia with isoflurane, sevoflurane, or desflurane and determine end-tidal inhalant concentration at certain events during recovery in healthy dogs.


METHODS
11 healthy dogs.


METHODS
Anesthesia was induced with propofol (IV), and dogs were assigned by use of a crossover design to receive isoflurane at 2.0%, sevoflurane at 3.2%, or desflurane at 11% end-tidal concentrations. Direct blood pressure was monitored throughout the 120 minutes of anesthesia. At the end of anesthesia, the circuit was flushed with oxygen, and the time to specific events in recovery and overall quality of recovery were assessed. Blood gas concentrations were measured prior to anesthesia and after recovery.


RESULTS
Dogs in the desflurane group had the shortest time to standing (11.7 +/- 5.1 minutes), followed by dogs in the sevoflurane group (18.6 +/- 7.5 minutes) and dogs in the isoflurane group (26.3 +/- 7.2 minutes). There was no difference for recovery quality among groups. Arterial blood pressure was higher in the sevoflurane group than in the desflurane group at 10 and 15 minutes and in the isoflurane group at 10, 15, 30, 45, 60, 75, 105, and 120 minutes. There were no significant differences among groups with respect to blood gas concentrations.


CONCLUSIONS
Results suggested that in dogs for which a short interval to standing is desired, desflurane is the best selection, followed by sevoflurane.
Lopez
Luis A
LA
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Hofmeister
Erik H
EH
Pavez
Juan C
JC
Brainard
Benjamin M
BM
D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation / Q000009:adverse effects / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000009:adverse effects / Q000494:pharmacology; D000818:Animals; D018592:Cross-Over Studies; D000077335:Desflurane; D004285:Dogs; D007530:Isoflurane / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008738:Methyl Ethers / Q000009:adverse effects / Q000494:pharmacology*; D000077149:Sevoflurane; D013997:Time Factors
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane