Synthesis of highly antibacterial nanocrystalline trivalent silver polydiguanide.
Highly monodispersed nanoparticles of a trivalent silver polydiguanide complex are synthesized by oxidation of the monovalent silver, followed by stabilization of the oxidized higher-valent metal through complexation with a polydiguanide ligand in a reverse microemulsion at room temperature. The synthesized nanoparticles have excellent photostability and displayed superior antibacterial activity toward Gram-positive and Gram-negative prokaryotes of clinical interest in vitro compared to silver sulfadiazine. These nanoparticles may serve as a new generation antibacterial metallopharmaceutical in wound care.
Pal
Sukdeb
S
Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul, 151-742, South Korea.
Yoon
Eun Jeong
EJ
Tak
Yu Kyung
YK
Choi
Eung Chil
EC
Song
Joon Myong
JM
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D004355:Drug Stability; D004655:Emulsions; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008024:Ligands; D053768:Metal Nanoparticles; D053758:Nanoparticles / Q000737:chemistry; D010084:Oxidation-Reduction; D018030:Silver Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D004655:Emulsions; D008024:Ligands; D018030:Silver Compounds