title: Associations of adiponectin with paraoxonase 1 and sE-selectin in hemodialyzed patients.
abstract: OBJECTIVE
  In hemodialyzed (HD) patients, adiponectin and sE-selectin levels are elevated, while antioxidant paraoxonase 1 activity (PON1) is decreased. We determined if the hyperadiponectinemia in HD patients has a protective effect on the decrease in PON1 and elevation in sE-selectin in kidney failure.
  
  
  METHODS
  Predialysis serum adiponectin, PON1 and sE-selectin as well as other metabolic variables were measured in 70 HD patients.
  
  
  RESULTS
  Adiponectin had (1) no association with PON1 or sE-selectin, (2) a positive association with dialysis efficiency and HDL-C, and (3) an inverse association with BMI, waist circumference, HOMA IR, triglyceride, hsCRP, fibrinogen, and albumin. Moreover, albumin, BMI, and HOMA-IR were independent negative predictors of adiponectin.
  
  
  CONCLUSIONS
  In kidney failure, in contrast to normal renal function, higher adiponectin levels had no correlation with PON1 activity or the sE-selectin level. However, adiponectin has an association with dialysis efficiency and, similar to individuals with preserved kidney function, traits of metabolic syndrome. In addition to BMI and HOMA-IR, the serum albumin concentration is also one of the independent negative predictors of the serum adiponectin level. Collectively, these findings may add details to the understanding of the role that adiponectin plays in chronic renal disease related to 'reverse epidemiology'.
authors.affiliation: Institute of Laboratory Medicine, University of Pecs, Pecs, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Peti
authors.forename: Botond
authors.initials: B
authors.lastname: Csiky
authors.forename: Eszter
authors.initials: E
authors.lastname: Guth
authors.forename: Peter
authors.initials: P
authors.lastname: Kenyeres
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Varga
authors.forename: Ildiko
authors.initials: I
authors.lastname: Seres
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Jeney
authors.forename: Maria
authors.initials: M
authors.lastname: Juhasz
authors.forename: Emese
authors.initials: E
authors.lastname: Mezosi
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Paragh
authors.forename: Gabor L
authors.initials: GL
authors.lastname: Kovacs
authors.forename: Laszlo
authors.initials: L
authors.lastname: Bajnok
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D043303:Aryldialkylphosphatase / Q000097:blood*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D003430:Cross-Sectional Studies; D019040:E-Selectin / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000097:blood* / Q000628:therapy*; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D019040:E-Selectin; D014280:Triglycerides; D005340:Fibrinogen; D002097:C-Reactive Protein; D043303:Aryldialkylphosphatase