[Drug delivery of CPC/cisplatin complex in vitro and its ability to repair bone defect and eliminate tumor in vivo].
OBJECTIVE
To explore the best mass ratio of calcium phosphate cement (CPC)/cisplatin complex filling and to repair bone defect caused by tumor resection.


METHODS
Mixed-molding method was used to obtain cisplatin/calcium phosphate cement complex at 0, 0.1%, 0.2%, and 0.4% mass ratio. Drug concentration was determined by atomic absorption spectrophotometry. Bone defect of rabbits and osteosarcoma of rats were prepared. We implanted CPC and CPC/cisplatin complex to observe the repair of bone defect and the inhibition of tumor in vivo.


RESULTS
CPC containing 0.1% approximately 0.2% cisplatin not only repaired the bone defect in rabbits but also eliminated osteosarcoma in rats.


CONCLUSIONS
CPC containing 0.1% approximately 0.2% cisplatin can repair bone defect and eliminate tumor without influencing the prosthetic precess.
Liu
Yanning
Y
Department of Orthopaedics, First Affiliated Hospital, Medical Shool of Xi'an Jiaotong University, Xi'an, China. liuyanninglyn@yahoo.com.cn
Liu
Miao
M
Ren
Pengyu
P
D000818:Animals; D001672:Biocompatible Materials; D001843:Bone Cements / Q000737:chemistry*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000601:surgery*; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000627:therapeutic use; D002130:Calcium Phosphates / Q000627:therapeutic use*; D002945:Cisplatin / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D005260:Female; D005264:Femoral Fractures / Q000601:surgery; D008297:Male; D051379:Mice; D008819:Mice, Nude; D012516:Osteosarcoma / Q000188:drug therapy / Q000601:surgery; D011817:Rabbits; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D001672:Biocompatible Materials; D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; D003692:Delayed-Action Preparations; C485838:calcium phosphate, monobasic, anhydrous; D002945:Cisplatin