Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever.
BACKGROUND
Crimean-Congo hemorrhagic fever (CCHF) is a public health problem in many countries. Chitotriosidase (ChT) is an enzyme secreted by activated macrophages that catalyzes the hydrolysis of chitin and chitin-like substrates. The goal of this study was to assess the relationship between serum ChT activity and mortality.


METHODS
ChT activities on the first day of hospitalization were analyzed in serum from 46 patients with CCHF and 36 healthy controls. Serum ChT activities and other clinical and laboratory parameters for patients with non-fatal and fatal CCHF were compared.


RESULTS
The median ChT activity was increased in all patients with CCHF [189.9 (134.8-246.6) nmol/mL/h]. The median ChT activity in the non-fatal CCHF group [220.2 (180.6-290.1) nmol/mL/h] was higher compared with the fatal CCHF group [29.2 (16.5-45.7) nmol/mL/h] (p<0.001). In univariate analysis, platelet count, lactate dehydrogenase (LDH), and activated partial thromboplastin time were associated with mortality.


CONCLUSIONS
This is the first study investigating the association of serum ChT enzyme activity with mortality from CCHF. This study suggested that relatively low ChT enzyme activities may be a prognostic marker in patients with CCHF.
Kurt
Yasemin Gulcan
YG
Department of Medical Biochemistry, Gulhane Military Medical Academy, Ankara, Turkey.
Cayci
Tuncer
T
Onguru
Pinar
P
Akgul
E Ozgur
EO
Yaman
Halil
H
Aydin
Ibrahim
I
Bodur
Hurrem
H
Turker
Turker
T
Kurt
Ismail
I
Cevik
M Aydin
MA
Erbil
M Kemal
MK
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006479:Hemorrhagic Fever, Crimean / Q000097:blood* / Q000201:enzymology; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
D006596:Hexosaminidases; C086400:chitotriosidase