title: Nephropathic complication of type-2 diabetes is following pattern of autoimmune diseases?
abstract: The impact of several environmental and genetic factors on diabetes and its complications is well documented. The present study was aimed to examine the serum levels of IL-17A and IFN-gamma as antagonistic cytokines in nephropathic and non-nephropathic type-2 diabetic patients. In this experimental study, serum samples were obtained from 180 type-2 diabetic patients, 100 nephropathic type-2 diabetic patients and 100 healthy controls. Serum levels of IL-17A and IFN-gamma was detected by ELISA. Results of this study showed that the serum level of IFN-gamma was higher in both diabetic patients (nephropathic and non-nephropathic) in comparison to the controls. In terms of IL-17A, while non-nephropathic type-2 diabetic patients showed an increased serum level of it, the other patients group had a lower serum level. Based on these findings, it can be concluded that the lower serum level of IL-17A is possibly associated with nephropathic complications of type-2 diabetes.
authors.affiliation: Dept. of Microbiology, Hematology and Immunology, Faculty of Medicine, Rafsanjan University of Medical Science, Rafsanjan, Iran. kazemim@modares.ac.ir
authors.forename: Mohammad Kazemi
authors.initials: MK
authors.lastname: Arababadi
authors.forename: Reza
authors.initials: R
authors.lastname: Nosratabadi
authors.forename: Gholamhossein
authors.initials: G
authors.lastname: Hassanshahi
authors.forename: Narges
authors.initials: N
authors.lastname: Yaghini
authors.forename: Vahid
authors.initials: V
authors.lastname: Pooladvand
authors.forename: Ali
authors.initials: A
authors.lastname: Shamsizadeh
authors.forename: Hamid
authors.initials: H
authors.lastname: Hakimi
authors.forename: Reza
authors.initials: R
authors.lastname: Derakhshan
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D004777:Environment; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D020381:Interleukin-17 / Q000097:blood*; D007492:Iran; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D020381:Interleukin-17; D007371:Interferon-gamma