title: Prostate cancer detection by TURP after repeated negative saturation biopsy in patients with persistent suspicion of cancer: a case-control study on 75 consecutive patients.
abstract: To evaluate prostate cancer (PCa) detection after repeated negative saturation biopsy, 75 patients, aged 53-78 years, underwent transurethral resection of prostate (TURP) because of persistent suspicion of cancer; median PSA was 11.8 ng ml(-1) and 58 men complained lower urinary tract symptoms (LUTS). In 12 (16%) and 3 (4%) men a T1a and T1b PCa was found with median PSA and Gleason score equal to 14.2 vs 23.6 ng ml(-1) and 5.6 vs 7 ng ml(-1). In case of persistent suspicion of PCa after repeated negative saturation biopsy, TURP may be proposed, aside from the coexistence of LUTS, to rule out a PCa, in younger patients with high PSA values (> or =20 ng ml(-1)).
authors.affiliation: Department of Urology, Cannizzaro Hospital, Catania, Italy. piepepe@hotmail.com
authors.forename: P
authors.initials: P
authors.lastname: Pepe
authors.forename: F
authors.initials: F
authors.lastname: Fraggetta
authors.forename: A
authors.initials: A
authors.lastname: Galia
authors.forename: G
authors.initials: G
authors.lastname: Grasso
authors.forename: F
authors.initials: F
authors.lastname: Aragona
mesh_terms: D000368:Aged; D001706:Biopsy; D016022:Case-Control Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D053448:Prostatism / Q000175:diagnosis; D020728:Transurethral Resection of Prostate
chemical_list: D017430:Prostate-Specific Antigen