[Comparison of Ca2+ responses to stimulation of glutamate receptors in the rat brain cortex following hypobaric hypoxia of different degree].
Hypoxia modifies glutamatergic signaling in the brain producing an increase of intracellular Ca2+ level. Depending on the power of survived hypoxia, degres and spatial-temporal profile of posthypoxic Ca2+ accumulation induce different Ca2+-dependent processes leading cells either to death or to hypoxia tolerance. To elucidate the specificity of different glutamate receptors involvement in these alternative processes the patterns of Ca2+ responses to stimulation of different subtype of ionotropic and metabolotropic glutamate receptors by their agonists were determined in perfused slices of piriform cortex obtained from the rats surviving either severe (pathogenic) or moderate (preconditioning) hypobaric hypoxia. It was shown that hypoxia of different modality modified Ca2+ responses of all tested receptor subtypes in different manner. The greatest difference was found for Ca2+ responses to stimulation of group I metabolotropic glutamate receptors.
Semenov
D G
DG
Beliakov
A V
AV
Samoĭlov
M O
MO
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D002525:Cerebellar Cortex / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017470:Receptors, Glutamate / Q000378:metabolism*
D017470:Receptors, Glutamate; D002118:Calcium