Long-term outcomes in pediatric liver transplantation.
1. Critical clinical outcomes for pediatric liver transplantation (LT) recipients include (1) patient and graft survival, (2) complications (immune and nonimmune) of chronic immunosuppressive medications, and (3) long-term graft function. 2. Recurrence of malignancy, sepsis, and posttransplant lymphoproliferative disorder account for more than 65% of deaths occurring more than 1 year after LT. 3. Chronic rejection, late hepatic artery thrombosis, and biliary strictures account for 70% of graft loss occurring more than 1 year after LT. 4. Late histological changes in the allograft are emerging as a common problem in patients more than 5 years after LT. The pathogenesis of these findings and the impact on graft survival remain to be determined.
Bucuvalas
John
J
Cincinnati Children's Hospital, Cincinnati, OH 45229-3039, USA. john.bucuvalas@cchmc.org
D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods / Q000401:mortality; D010349:Patient Compliance; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology; D011788:Quality of Life; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
D007166:Immunosuppressive Agents