Obesity and family history of diabetes as risk factors of impaired fasting glucose: implications for the early detection of prediabetes.
OBJECTIVE
To determine whether the association between family history of diabetes (FHD) and impaired fasting glucose (IFG) is independent of body mass index (BMI) in children and adolescents.


METHODS
In all 443 (11.9%) children and adolescents with FHD, and 3280 (88.1%) without FHD were enrolled in a population-based cross-sectional study. Eligible subjects to participate were apparently healthy children and adolescents aged 7-15 yr from Middle and Northern Mexico. Obesity was defined by age- and gender-specific BMI >or= 95th percentile. FHD was defined as positive if at least one first degree relative had diabetes. The IFG was defined by fasting plasma glucose >or= 100 mg/dL and < 126 mg/dL.


RESULTS
IFG was identified in 390 (88.0%) and 62 (1.9%) children and adolescents with and without FHD, respectively. In the group with positive FHD, IFG was diagnosed in 146 (37.4%), 79 (20.2%), and 165 (42.3%) children and adolescents who were obese, overweight, and normal-weight, respectively. On the other hand, in the group without FHD, IFG was identified in 21 (33.9%), 14 (22.6%), and 27 (43.5%) children and adolescents who were obese, overweight, and normal-weight, respectively. In the overall population, the age-, sex-, and BMI-adjusted logistic regression analysis showed a strong and independent association between FHD and IFG [odds ratio (OR) -11.7; 95% CI 9.5-21.2]. This association remained strong for girls and boys in a subsequent analysis stratified for BMI category.


CONCLUSIONS
The presence of FHD in a first degree relative is associated with IFG, even in the absence of obesity.
Rodríguez-Moran
Martha
M
Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico.
Guerrero-Romero
Fernando
F
Aradillas-García
Celia
C
Violante
Rafael
R
Simental-Mendia
Luis E
LE
Monreal-Escalante
Elizabeth
E
Mendoza
Esperanza de la Cruz
Ede L
D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis / Q000502:physiology; D015992:Body Mass Index; D002648:Child; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000235:genetics; D042241:Early Diagnosis; D005215:Fasting / Q000502:physiology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology* / Q000235:genetics; D011236:Prediabetic State / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics; D012307:Risk Factors
D001786:Blood Glucose