Concomitant dehydration mechanisms in single crystals of alpha,alpha-trehalose.
The dehydration behaviour of alpha,alpha-trehalose (alpha-D-glucopyranosyl alpha-D-glucopyranoside) dihydrate single crystals is investigated by thermomicroscopy, Raman microscopy, and differential scanning calorimetry. The results show at a given stage the simultaneous presence of two polymorphic forms, amorphous material, and movement of a fluid phase. The study also underlines that the characterization of the average phase by conventional XRPD and DSC techniques is not sufficient to describe the dehydration mechanisms of alpha,alpha-trehalose particles. Moreover, it confirms that the dehydration behaviour is mainly driven by heterogeneities and the rate of water loss.
Dupray
Valérie
V
La2B-SMS UPRES EA3233, Centre Universitaire d'Evreux, Université de Rouen, Evreux Cedex, France. valerie.dupray@univ-rouen.fr
Berton
Benjamin
B
Ossart
Stephen
S
Atmani
Hassan
H
Petit
Marie-Noëlle
MN
Coquerel
Gérard
G
D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D003890:Desiccation; D008853:Microscopy; D013059:Spectrum Analysis, Raman; D014199:Trehalose / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D014867:Water; D014199:Trehalose