The anti-hyperglycemic effect of plants in genus Gynura Cass.
Gynura divaricata (L.) DC and G. bicolor DC are used as secret recipes to treat diabetes mellitus in some parts of China. Pharmacological tests were performed to prove the anti-hyperglycemic effect of these two plants of genus Gynura Cass. in this study. Both water and 95% ethanol extracts of fresh G. divaricata had significant effects on lowering blood glucose level in normal mice, in which the dose of 0.4 g (crude drug)/kg of 95% ethanol extract was more effective than 50 mg/kg glyburide. The ethyl acetate and n-butanol extracts of dried G. divaricata had significant effects on lowering blood glucose level in normal and alloxan diabetic mice too. Both ethyl acetate and n-butanol extracts of dried G. bicolor showed very significant effect on lowering blood glucose level to normal and alloxan-diabetic mice, and the dose 4.0 g (crude drug)/kg had a more hypoglycemic effect than 50 mg/kg glyburide in normal mice.
Li
Wei-Lin
WL
Institute of Botany, Jiangsu Province, Nanjing, Jiangsu, China. lwlcnbg@mail.cnbg.net
Ren
Bing-Ru
BR
Min-Zhuo
Hu
Yong
Y
Lu
Chang-Gen
CG
Wu
Ju-Lan
JL
Chen
Jian
J
Sun
Shi
S
D020001:1-Butanol / Q000737:chemistry; D000085:Acetates / Q000737:chemistry; D000496:Alloxan; D000818:Animals; D019659:Asteraceae / Q000737:chemistry* / Q000145:classification; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry; D005260:Female; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013045:Species Specificity; D014867:Water / Q000737:chemistry
D000085:Acetates; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D014867:Water; D000431:Ethanol; D000496:Alloxan; C007650:ethyl acetate; D020001:1-Butanol; D005905:Glyburide