title: Alotaketals A and B, sesterterpenoids from the marine sponge Hamigera species that activate the cAMP cell signaling pathway.
abstract: The new sesterterpenoids alotaketals A (1) and B (2) have been isolated from extracts of the marine sponge Hamigera sp. collected in Papua New Guinea. Their chemical structures were elucidated by analysis of spectroscopic data. Alotaketals A and B have the unprecedented alotane carbon skeleton, and they activate the cAMP cell signaling pathway with EC(50)'s of 18 and 240 nM, respectively.
authors.affiliation: Department of Chemistry and Earth & Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.
authors.forename: Roberto
authors.initials: R
authors.lastname: Forestieri
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Merchant
authors.forename: Nicole J
authors.initials: NJ
authors.lastname: de Voogd
authors.forename: Teatulohi
authors.initials: T
authors.lastname: Matainaho
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Kieffer
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Andersen
mesh_terms: D000818:Animals; D002460:Cell Line; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*; D013045:Species Specificity; D013237:Stereoisomerism
chemical_list: D054830:Sesterterpenes; C546269:alotaketal A; C546268:alotaketal B; D000242:Cyclic AMP