PARsing the phrase "all in for Axin"- Wnt pathway targets in cancer.
Genetic alternations resulting in constitutive stabilization of beta-catenin and altered transcription of beta-catenin/TCF-regulated genes are found in many cancers. A recent Nature paper offers insights into the role of tankyrase in regulating the Wnt/beta-catenin pathway and suggests that compounds targeting tankyrase's poly-ADP-ribosylation (PARsylation) activity may hold promise for cancer therapy.
Fearon
Eric R
ER
Division of Molecular Medicine & Genetics, Departments of Internal Medicine, Human Genetics and Pathology, and The Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109-22200, USA. fearon@umich.edu
D060466:Axin Protein; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D038501:Tankyrases / Q000235:genetics / Q000378:metabolism*; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
D060466:Axin Protein; D012097:Repressor Proteins; D051153:Wnt Proteins; D051176:beta Catenin; D011064:Poly Adenosine Diphosphate Ribose; D038501:Tankyrases