title: Patient motivation for participating in clinical trials for depression: validation of the motivation for clinical trials inventory-depression.
abstract: The motivation for clinical trials inventory-depression (MCTI-D) was developed and evaluated for assessing motivations to participate in clinical trials on depression. Sixty-four participants completed the MCTI-D: 40 individuals expressing interest in participating in a randomized clinical trial (RCT); and 24 clinic patients receiving traditional care for depression. Content validity was supported by feedback derived from a panel of experts in depression research and respondents completing the measure. The motivation most frequently endorsed for participating in an RCT was the desire to help others and/or to further science. The potential stigma associated with seeing a psychiatrist was reported to have the least influence. Patients expressed a greater likelihood to participate in RCTs that involved psychotherapy than in experimental medication or placebo-controlled trials. Data from the MCTI-D may provide useful information for depression researchers to consider as possible influences on patients' decisions about whether or not they will participate.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Road, Stanford University, Stanford,CA 94305-5718, USA.
authors.forename: Emily L
authors.initials: EL
authors.lastname: Andresen
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Wilson
authors.forename: Adelaida
authors.initials: A
authors.lastname: Castillo
authors.forename: Cheryl
authors.initials: C
authors.lastname: Koopman
mesh_terms: D000328:Adult; D003863:Depression / Q000523:psychology*; D004522:Educational Status; D005006:Ethnicity / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009042:Motivation; D011594:Psychometrics / Q000379:methods; D016032:Randomized Controlled Trials as Topic / Q000523:psychology*; D035842:Research Subjects / Q000523:psychology*; D012727:Sex Characteristics