Increased glucose utilization in Corynebacterium glutamicum by use of maltose, and its application for the improvement of L-valine productivity.
Corynebacterium glutamicum efficiently utilizes maltose as a substrate. We show here that the presence of maltose increases glucose utilization by raising the expression of ptsG, which encodes the glucose-specific EII permease of the phosphotransferase system. Consequently, the L-valine productivity of a pyruvate dehydrogenase complex-deficient C. glutamicum strain was improved by the presence of maltose.
Krause
Felix S
FS
Institute of Microbiology and Biotechnology, University of Ulm, Ulm, Germany.
Henrich
Alexander
A
Blombach
Bastian
B
Krämer
Reinhard
R
Eikmanns
Bernhard J
BJ
Seibold
Gerd M
GM
D001426:Bacterial Proteins / Q000096:biosynthesis; D048230:Corynebacterium glutamicum / Q000254:growth & development / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D008320:Maltose / Q000378:metabolism*; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System / Q000096:biosynthesis; D011768:Pyruvate Dehydrogenase Complex / Q000235:genetics; D014633:Valine / Q000096:biosynthesis*
D001426:Bacterial Proteins; D011768:Pyruvate Dehydrogenase Complex; D008320:Maltose; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System; C031629:phosphoenolpyruvate-glucose phosphotransferase; D014633:Valine; D005947:Glucose