title: Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples.
abstract: Previous studies have found haplotypic association of HTR4 variants and schizophrenia. Examining case-control pairs, G-G of rs7713886 was associated with schizophrenia risk. The A-A-G-G-G-A-A rs9325104-rs1422636-rs7715569-rs6873382-rs7711800-rs10078551-rs2068190 haplotype was overrepresented in the schizophrenia cases. The associations were no longer significant after corrections for multiple comparisons. No association was found in the family sample.
authors.affiliation: Neurogenetics Section, CAMH, Toronto, ON, Canada.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hirata
authors.forename: Renan P
authors.initials: RP
authors.lastname: Souza
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Lieberman
authors.forename: Herbert Y
authors.initials: HY
authors.lastname: Meltzer
authors.forename: James L
authors.initials: JL
authors.lastname: Kennedy
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D044422:Receptors, Serotonin, 5-HT4 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D044422:Receptors, Serotonin, 5-HT4