title: 1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands.
abstract: 1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines were prepared. Binding assays indicated they are 5-HT(6) receptor ligands, among which 6f and 6g showed high affinity for 5-HT(6) receptors with K(i)=3.9 and 1.7 nM, respectively.
authors.affiliation: Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. bernotr@wyeth.com
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Bernotas
authors.forename: Schuyler A
authors.initials: SA
authors.lastname: Antane
authors.forename: Steven E
authors.initials: SE
authors.lastname: Lenicek
authors.forename: Simon N
authors.initials: SN
authors.lastname: Haydar
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Robichaud
authors.forename: Boyd L
authors.initials: BL
authors.lastname: Harrison
authors.forename: Guo Ming
authors.initials: GM
authors.lastname: Zhang
authors.forename: Deborah
authors.initials: D
authors.lastname: Smith
authors.forename: Joseph
authors.initials: J
authors.lastname: Coupet
authors.forename: Lee E
authors.initials: LE
authors.lastname: Schechter
mesh_terms: D006367:HeLa Cells; D006801:Humans; D008024:Ligands; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D012702:Serotonin Antagonists / Q000737:chemistry / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D008024:Ligands; D011725:Pyridines; D011758:Pyrroles; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C097216:serotonin 6 receptor; C486292:pyrrolo(2, 3-b)pyridine