title: PI3 kinase signals BCR-dependent mature B cell survival.
abstract: Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence that the survival of BCR deficient mature B cells can be rescued by a single signaling pathway downstream of the BCR, namely PI3K signaling, with the FOXO1 transcription factor playing a central role.
authors.affiliation: Program of Cellular and Molecular Medicine, Children's Hospital, and Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Srinivasan
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Dinis Pedro
authors.initials: DP
authors.lastname: Calado
authors.forename: Baochun
authors.initials: B
authors.lastname: Zhang
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Paik
authors.forename: Ronald A
authors.initials: RA
authors.lastname: DePinho
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Kutok
authors.forename: John F
authors.initials: JF
authors.lastname: Kearney
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Otipoby
authors.forename: Klaus
authors.initials: K
authors.lastname: Rajewsky
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000378:metabolism*; D002470:Cell Survival; D051379:Mice; D018345:Mice, Knockout; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011947:Receptors, Antigen, B-Cell; D019869:Phosphatidylinositol 3-Kinases