title: C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population.
abstract: BACKGROUND
  We studied the association of C-reactive protein (CRP), gamma-glutamyltransferase (GGT) and type 2 diabetes in Chinese.
  
  
  METHODS
  A population-based cross-sectional study.
  
  
  RESULTS
  CRP and GGT levels were significantly higher in participants with diabetes than in those without (P<0.001). Higher CRP levels were positively associated with prevalent type 2 diabetes after adjustment for age, sex, smoking, alcohol consumption, physical activity, family history of diabetes, body mass index, waist circumference, waist/hip ratio, education, systolic blood pressure, triglycerides, high density lipoprotein cholesterol, use of antihypertensive drugs, aspirin and lipid-lowering agents, with multivariable odds ratios (OR) of 1.55 (95% confidence interval (CI), 1.05-2.27, P trend=0.005, comparing quartile 4 to quartile 1). However, after further adjustment for GGT, the association was completely attenuated (fourth quartile OR 1.23, 95% CI, 0.83-1.82, P trend=0.127). Moreover, the association of CRP and prevalent type 2 diabetes was stronger in subjects with GGT values above the median than in those with GGT values below the median. Increasing serum GGT quartiles were positively associated with prevalent type 2 diabetes after adjustment for potential confounding variables (P for trend <0.001).
  
  
  CONCLUSIONS
  CRP may not be an independent risk factor for type 2 diabetes, at least in Chinese people.
authors.affiliation: Department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Jiangping
authors.initials: J
authors.lastname: Wen
authors.forename: Yuanbo
authors.initials: Y
authors.lastname: Liang
authors.forename: Fenghua
authors.initials: F
authors.lastname: Wang
authors.forename: Lanping
authors.initials: L
authors.lastname: Sun
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Guo
authors.forename: Xinrong
authors.initials: X
authors.lastname: Duan
authors.forename: Xiangyi
authors.initials: X
authors.lastname: Liu
authors.forename: Tien Yin
authors.initials: TY
authors.lastname: Wong
authors.forename: Xinxin
authors.initials: X
authors.lastname: Lu
authors.forename: Ningli
authors.initials: N
authors.lastname: Wang
mesh_terms: D000328:Adult; D044466:Asian People; D002097:C-Reactive Protein / Q000378:metabolism*; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000201:enzymology / Q000453:epidemiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D002097:C-Reactive Protein; D005723:gamma-Glutamyltransferase