Multiple convergence in polyketide biosynthesis: a third folding mode to the anthraquinone chrysophanol.
The polyketide chrysophanol is shown to be formed, in an organism-specific way, by a third folding mode, involving a remarkable cyclization of a bicyclic diketo precursor, thus establishing the first example of multiple convergence in polyketide biosynthesis.
Bringmann
Gerhard
G
Institute of Organic Chemistry, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany. bringman@chemie.uni-wuerzburg.de
Gulder
Tobias A M
TA
Hamm
Andreas
A
Goodfellow
Michael
M
Fiedler
Hans-Peter
HP
D000880:Anthraquinones; D003500:Cyclization; D056890:Eukaryota; D018942:Macrolides; D053858:Metabolic Networks and Pathways; D048630:Polyketide Synthases / Q000378:metabolism; D011387:Prokaryotic Cells
D000880:Anthraquinones; D018942:Macrolides; D048630:Polyketide Synthases; C027113:chrysophanic acid