title: Prevalence of pilus-encoding islets among acute otitis media Streptococcus pneumoniae isolates from Israel.
abstract: We evaluated the distribution of the two known Streptococcus pneumoniae pilus encoding islets (PI-1 and PI-2) among a panel of 113 acute otitis media clinical isolates from Israel. PI-1 was present in 30.1% (n = 34) of the isolates tested, and PI-2 was present in 7% (n = 8). In addition, we found that: (i) the PI positive isolates, 50% of which belong to the international clones Spain(9V)-3 (ST156) and Taiwan(19F)-14 (ST236), correlate with the genotype (as determined by multilocus sequence typing) but not with the serotype; (ii) PI-2 was not present in the absence of Pl-1; and (iii) the frequency of PI-1 was higher among antibiotic-resistant isolates.
authors.affiliation: Novartis Vaccines and Diagnostics srl, Research Center, Siena, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Moschioni
authors.forename: G
authors.initials: G
authors.lastname: De Angelis
authors.forename: S
authors.initials: S
authors.lastname: Melchiorre
authors.forename: V
authors.initials: V
authors.lastname: Masignani
authors.forename: E
authors.initials: E
authors.lastname: Leibovitz
authors.forename: M A
authors.initials: MA
authors.lastname: Barocchi
authors.forename: R
authors.initials: R
authors.lastname: Dagan
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015373:Bacterial Typing Techniques; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D010861:Fimbriae, Bacterial / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007557:Israel / Q000453:epidemiology; D008297:Male; D010033:Otitis Media / Q000453:epidemiology* / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D015995:Prevalence; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents