title: Clinical presentation can predict disease course in patients with intraductal papillary mucinous neoplasm of the pancreas.
abstract: BACKGROUND
  Preoperative diagnosis of malignancy within intraductal papillary mucinous neoplasm of the pancreas (IPMN) solely by clinical or radiological findings is not always possible. We sought a correlation between preoperative clinico-radiological findings and outcome.
  
  
  METHODS
  A prospective database of pancreatic resections for IPMN (2002-2008) and a retrospective pathological revision of all pancreatic cancer specimens (1995-2001) were analyzed. The patients were grouped into asymptomatic with preoperative diagnosis of IPMN (group 1), symptomatic with a preoperative diagnosis of IPMN (group 2), and those with a preoperative diagnosis of pancreatic cancer whose specimen revealed a background of IPMN (group 3). The groups were compared for demographics, clinical presentation, pathological findings, and outcome.
  
  
  RESULTS
  Of the 62 patients with IPMN, 19 were in group 1, 23 in group 2, and 20 in group 3. Their median age (range) was 65.6 (46-80), 67 (50-84), and 73.4 (57-86) years, respectively. The clinical presentation for groups 2 and 3 included abdominal pain (56% vs. 32 %), weight loss (8% vs. 52%), obstructive jaundice (4% vs. 57%), pancreatitis (22% and 5%), and new onset of diabetes (14% and 44%). Invasive cancer was found in one patient in group 1 (5.2%), two patients in group 2 (8.7%), and all patients in group 3. IPMN was present in 23 of 217 (10.6%) of all resected pancreatic cancer specimens. Five year survival for patients with invasive disease was 47% and 92% for patients with noninvasive disease (mean follow-up 37.6 months).
  
  
  CONCLUSIONS
  Benign IPMN can usually be differentiated from adenocarcinoma preoperatively. The clinical presentation is highly indicative of disease course.
authors.affiliation: Department of Surgery B, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel-Aviv, Israel. nir_lubezky@hotmail.com
authors.forename: Nir
authors.initials: N
authors.lastname: Lubezky
authors.forename: Menahem
authors.initials: M
authors.lastname: Ben-Haim
authors.forename: Richard
authors.initials: R
authors.lastname: Nakache
authors.forename: Guy
authors.initials: G
authors.lastname: Lahat
authors.forename: Arye
authors.initials: A
authors.lastname: Blachar
authors.forename: Eli
authors.initials: E
authors.lastname: Brazowski
authors.forename: Erwin
authors.initials: E
authors.lastname: Santo
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Klausner
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D018450:Disease Progression; D019160:Endosonography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed