Mannose-binding lectin in pre-menopausal women with recurrent urinary tract infections.
Mannose-binding lectin (MBL) comprises an oligomeric serum protein that is a member of the collectin class of the C-type lectin superfamily. Its deficiency is genetically determined and confers predisposition to recurrent infections as well as increased infection severity. This correlation has been demonstrated in recurrent furunculosis caused by Staphylococcus aureus, and in pneumococcal and Candida infections. The present study aimed to determine whether there is a correlation between MBL serum levels and recurrent urinary tact infections (UTI) in pre-menopausal women. The present aged-matched double-blind controlled study was conducted in 100 pre-menopausal adult women: 50 who suffered from recurrent UTI and 50 without UTI. The MBL concentration was measured in a single serum sample from each patient using an enzyme-linked immunosorbent assay. MBL serum levels [median (range)] were 2500 (4-12,000) ng/mL and 2105 (4-22,800) ng/mL for the research and control groups, respectively. The results from the two groups were compared and were not statistically different (p 0.4). According to these results, MBL serum levels are not associated with an increased risk for recurrent UTI in pre-menopausal women.
Colodner
R
R
Laboratory Medicine Department, Ha'Emek Medical Center, Afula, Israel. colodner_ra@clalit.org.il
Nitzan
O
O
Chazan
B
B
Edelstein
H
H
Raz
R
R
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004311:Double-Blind Method; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D037601:Mannose-Binding Lectin / Q000097:blood* / Q000172:deficiency; D008875:Middle Aged; D017697:Premenopause; D012008:Recurrence; D014552:Urinary Tract Infections / Q000453:epidemiology*; D055815:Young Adult
D037601:Mannose-Binding Lectin