title: Tetherin is as tetherin does.
abstract: Tetherin is a cellular restriction factor that inhibits the release of HIV and other enveloped viruses from host cells. A paper from Perez-Caballero et al. (2009) in this issue of Cell clarifies how this factor works. The authors show that the aptly named tetherin directly tethers viral particles to the plasma membrane.
authors.affiliation: Emory University and Children's Healthcare of Atlanta, Atlanta, GA 30322, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Hammonds
authors.forename: Paul
authors.initials: P
authors.lastname: Spearman
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D058851:GPI-Linked Proteins; D015497:HIV-1 / Q000378:metabolism; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D014771:Virion / Q000378:metabolism*; D000074010:Bone Marrow Stromal Antigen 2
chemical_list: D015703:Antigens, CD; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; C094572:BST2 protein, human; D000074010:Bone Marrow Stromal Antigen 2