Fenofibrate reduces adiposity in pregnant and virgin rats but through different mechanisms.
Fenofibrate has been proven to reduce adiposity. Since gestation produces an increase in white adipose tissue (WAT) mass, we comparatively studied this drug-effect in virgin and pregnant rats. Fenofibrate reduced lumbar WAT weight in both pregnant and virgin rats. Fenofibrate treatment did not modify plasma free fatty acid (FFA) concentration in virgin rats, it greatly increased it in pregnant animals. Remarkable differences between the two groups were obtained for two proteins related to fatty acid oxidation and esterification and storing. Respectively, the mRNA levels of carnitine palmitoyltransferase I (CPT-I) were increased by the fenofibrate only in the virgin rats and a similar finding was observed for the expression of phosphoenolpyruvate carboxykinase (PEPCK). These findings indicate that fenofibrate reduces adiposity in pregnant and virgin rats through different mechanisms: a) in virgin rats, by promoting fatty acid oxidation; and b) in pregnant rats, by enhancing fatty acid output.
Gonzalez
Maréa del Carmen
MC
Facultades de Farmacia y Medicina, Universidad CEU San Pablo, Montepríncipe, Boadilla del Monte, Madrid, Spain.
Vidal
Hubert
H
Herrera
Emilio
E
Bocos
Carlos
C
D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D052436:Adipose Tissue, White / Q000166:cytology / Q000187:drug effects; D050154:Adiposity / Q000187:drug effects*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood; D005260:Female; D011345:Fenofibrate / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley
D015415:Biomarkers; D005227:Fatty Acids; D011345:Fenofibrate