title: Validation of the calculation of the clearance rate constant (k(mono)) of [(11)C]acetate using parametric k(mono) image for myocardial oxidative metabolism.
abstract: BACKGROUND
  The purpose of this study was to validate the calculation of myocardial oxidative metabolism rate using a parametric clearance rate constant (k(mono)) image.
  
  
  METHODS
  Fifteen subjects (seven volunteers, eight patients) were studied. Dynamic PET was acquired after intravenous injection of 700 MBq of [(11)C]acetate. The clearance rate constant of [(11)C]acetate (k(mono)) was calculated pixel by pixel to generate the parametric k(mono) image. The k(mono) values from this image and those calculated from the dynamic image were compared in the same regions of interest (ROIs).
  
  
  RESULTS
  Two different methods showed an excellent correlation except in the very low range. Regression equations were y=0.99x+0.0034 (r(2)=0.86, P<.001) and y=1.16x-0.0077 (r(2)=0.87, P<.001) in normal volunteer and patient groups, respectively, and y=1.07x-0.0019 (r(2)=0.87, P<.001) when combined.
  
  
  CONCLUSIONS
  Both methods exhibited similar values of k(mono). Parametric k(mono) image may result in better visual understanding of regional myocardial oxidative metabolism.
authors.affiliation: Biomedical Imaging Research Center, University of Fukui, Fukui, Japan. raihan_h@yahoo.com
authors.forename: Raihan
authors.initials: R
authors.lastname: Hussain
authors.forename: Takashi
authors.initials: T
authors.lastname: Kudo
authors.forename: Testuya
authors.initials: T
authors.lastname: Tsujikawa
authors.forename: Masato
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Fujibayashi
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Okazawa
mesh_terms: D000085:Acetates / Q000493:pharmacokinetics*; D000328:Adult; D000368:Aged; D002244:Carbon / Q000493:pharmacokinetics*; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D000085:Acetates; D019275:Radiopharmaceuticals; C438206:carbon-11 acetate; D002244:Carbon; D010100:Oxygen