Comparative histomorphometric analysis of extraction sockets healing implanted with bovine xenografts, irradiated cancellous allografts, and solvent-dehydrated allografts in humans.
OBJECTIVE
Bovine-derived bone xenograft and mineralized cancellous bone allograft have been successfully used as bone substitutes in dental surgery, but few clinical studies in humans have been reported. The objective of this study was to compare the osteoconductive effects of deproteinized bovine bone mineral (DBBM), irradiated cancellous allograft (ICA), and solvent-dehydrated allograft (SDA) when used to preserve extraction sockets.


METHODS
Twenty patients received bone grafting in extraction sockets with DBBM (n = 7), ICA (n = 8), or SDA (n = 5). Core biopsies were taken from each graft site 4 to 6 months after grafting and were evaluated histomorphometrically. One-way analysis of variance was used to compare each variable. P values less than .05 were considered significant.


RESULTS
DBBM induced more new bone deposition in the periphery of the native bone particles than ICA or SDA, whereas ICA and SDA were more frequently surrounded by fibrous tissue than DBBM. In addition, DBBM retained more residual graft bony particles than ICA or SDA.


CONCLUSIONS
Based on these findings, the DBBM showed more of an osteoconductive effect than ICA or SDA, producing a more rigid bony structure. It is therefore suggested that DBBM may be more favorable for the preservation of extraction sockets than allogeneic graft materials.
Lee
Dong-Woon
DW
Department of Periodontology, Seoul Veterans Hospital, Seoul, South Korea.
Pi
Sung-Hee
SH
Lee
Suk-Keun
SK
Kim
Eun-Cheol
EC
D000328:Adult; D000368:Aged; D000540:Alveolar Ridge Augmentation / Q000379:methods; D000818:Animals; D001706:Biopsy; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D055113:Chronic Periodontitis / Q000601:surgery; D003238:Connective Tissue / Q000473:pathology; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D010012:Osteogenesis / Q000502:physiology; D014021:Tissue Preservation / Q000379:methods; D014081:Tooth Extraction; D020390:Tooth Socket / Q000473:pathology / Q000601:surgery*; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous; D014945:Wound Healing / Q000502:physiology
C077540:Bio-Oss; D018786:Bone Substitutes; D015921:Dental Implants; D008903:Minerals