title: Hypnotic and sleep quality-enhancing properties of kavain in sleep-disturbed rats.
abstract: The present study was performed to investigate the effects of kavain on the sleep-wake cycle in comparison with that of rilmazafone and diphenhydramine using sleep-disturbed rats. Electrodes for the electroencephalogram (EEG) and electromyogram (EMG) were implanted into Wistar rats. Total awake time, non-rapid eye movement (non-REM) sleep and rapid eye movement (REM) sleep were measured for 6 h. Kavain and rilmazafone showed a significant shortening in sleep latency, decreased awake time, and increased non-REM sleep time. On the other hand, significant shortening of the sleep latency was observed following the administration of diphenhydramine, while no effects were observed on the awake and non-REM sleep time. Moreover, kavain showed a significant increase in delta activity during non-REM sleep in sleep-disturbed rats, whereas a significant decrease in delta power during non-REM sleep was observed with rilmazafone. These results clearly indicate that kavain is a compound with not only hypnotic effects, but also sleep quality-enhancement effects.
authors.affiliation: Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
authors.forename: Ryuki
authors.initials: R
authors.lastname: Tsutsui
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Shinomiya
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takeda
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Obara
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kamei
mesh_terms: D000818:Animals; D003700:Delta Rhythm / Q000187:drug effects; D004155:Diphenhydramine / Q000494:pharmacology; D004569:Electroencephalography / Q000187:drug effects; D004576:Electromyography / Q000187:drug effects; D006993:Hypnotics and Sedatives; D008297:Male; D011753:Pyrones / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects*; D012893:Sleep Wake Disorders / Q000188:drug therapy*; D014230:Triazoles / Q000494:pharmacology; D014851:Wakefulness / Q000187:drug effects
chemical_list: D006993:Hypnotics and Sedatives; D011753:Pyrones; D014230:Triazoles; D004155:Diphenhydramine; C041075:rilmazafone; C011889:kavain