title: Psychiatric comorbidity and suicidal behavior in epilepsy: a community-based case-control study.
abstract: OBJECTIVE
  To provide information about psychiatric comorbidity and suicidal behavior in people with epilepsy compared to those without epilepsy from a community sample in Brazil.
  
  
  METHODS
  An attempt was made to evaluate all 174 subjects with epilepsy (cases) identified in a previous survey. For every case identified, an individual without epilepsy (control) matched by sex and age was selected in the same neighborhood. A structured interview with validated psychiatric scales was performed. One hundred and fifty-three cases and 154 controls were enrolled in the study.
  
  
  RESULTS
  People with epilepsy had anxiety more frequently [39.4% vs. 23.8%, odds ratio (OR) 2.1, 95% confidence interval (CI) 1.2-3.5; p = 0.006], depression (24.4% vs. 14.7%, OR 1.9, 95% CI 1.01-3.5; p = 0.04), and anger (55.6% vs. 39.7%, OR 1.9, 95% CI 1.2-3.1; p = 0.008). They also reported more suicidal thoughts [36.7% vs. 23.8%, OR 1.8, 95% CI 1.1-3.1; p = 0.02), plans (18.2% vs. 3.3%, OR 2.0, 95% CI 1.0-4.0; p = 0.04), and attempts (12.1% vs. 5.3%, OR 2.4, 95% CI 1.1-3.2, p = 0.04) during life than controls.
  
  
  CONCLUSIONS
  These findings call attention to psychiatric comorbidity and suicidal behavior associated with epilepsy. Suicide risk assessment, mental evaluation, and treatment may improve quality of life in epilepsy and ultimately prevent suicide.
authors.affiliation: Department of Medical Psychology and Psychiatry, Faculty of Medicine, UNICAMP, Campinas, SP, Brazil. sabrinas@fcm.unicamp.br
authors.forename: Sabrina
authors.initials: S
authors.lastname: Stefanello
authors.forename: Letícia
authors.initials: L
authors.lastname: Marín-Léon
authors.forename: Paula T
authors.initials: PT
authors.lastname: Fernandes
authors.forename: Li M
authors.initials: LM
authors.lastname: Li
authors.forename: Neury J
authors.initials: NJ
authors.lastname: Botega
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D015897:Comorbidity; D004827:Epilepsy / Q000453:epidemiology* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology* / Q000523:psychology*; D008875:Middle Aged; D012111:Residence Characteristics; D013405:Suicide / Q000523:psychology*; D011795:Surveys and Questionnaires; D055815:Young Adult; D000092864:Suicide Prevention