Systematic review: family history in risk assessment for common diseases.
BACKGROUND
The usefulness of routinely examining family history in primary care practice is uncertain.


OBJECTIVE
To assess the beneficial and adverse effects of collecting family history in primary care populations; how well family history predicts individual disease risk; and how accurately patients report it.


METHODS
English-language studies in MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, and PsycINFO from 1995 to 2 March 2009.


METHODS
Two independent reviewers selected studies that met question-specific eligibility criteria. These included controlled and uncontrolled intervention studies of systematic family history collection and uptake of preventive interventions or adverse effects, longitudinal and cross-sectional studies that examined family history and disease frequency, and studies in which reported family history was validated against relatives' true disease status.


METHODS
Information about study quality, setting, and findings was extracted using standardized protocols.


RESULTS
Two uncontrolled studies provided insufficient evidence to assess whether querying about family history improves any outcomes. One randomized, controlled trial and 2 uncontrolled studies provided weak evidence that some patients experienced a reversible, short-term increase in anxiety associated with family history taking. In 41 studies, different family history definitions were associated with sensitivities of 0 to 0.51 and specificities of 0.66 to 1.00 for detection of disease risk, and 0 to 0.83 and 0.48 to 1.00, respectively, for detection of prevalent disease. Twenty-three studies suggested that absence of disease in relatives was more accurately reported than presence of disease and that reporting accuracy was higher for information related to first-degree relatives than more distant relatives.


CONCLUSIONS
Few studies were designed to address the specific questions of interest.


CONCLUSIONS
Insufficient evidence evaluates how to collect family history information accurately in the primary care setting and the effects of taking family history on patient outcomes. Patients seem to correctly report the absence of disease in relatives more often than the presence of disease.
Wilson
Brenda J
BJ
University of Ottawa, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Qureshi
Nadeem
N
Santaguida
Pasqualina
P
Little
Julian
J
Carroll
June C
JC
Allanson
Judith
J
Raina
Parminder
P
D005192:Family Health; D005544:Forecasting; D006304:Health Status; D006801:Humans; D008487:Medical History Taking / Q000592:standards; D017063:Outcome Assessment, Health Care; D011320:Primary Health Care / Q000379:methods* / Q000592:standards / Q000639:trends; D018570:Risk Assessment