Antibiotics and asthma in children.
(1) A longitudinal cohort study showed an increase in the frequency of asthma among 7-year-old children who were treated with antibiotics during the first year of life, even when treatment was for non-respiratory tract infections. The risk increased with the number of antibiotic courses with the use of broad-spectrum antibiotics; (2) A meta-analysis of epidemiological studies showed that the risk of asthma doubled when antibiotics were administered during the first year of life. No such link was found in the combined analysis of the few existing prospective studies; (3) In practice, the likely benefits and risks should be carefully weighed before prescribing an antibiotic to a child. A narrow-spectrum antibiotic should be chosen whenever possible.
D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001249:Asthma / Q000139:chemically induced*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D011307:Drug Prescriptions; D004363:Drug Utilization; D006801:Humans; D007223:Infant; D007239:Infections / Q000188:drug therapy; D015201:Meta-Analysis as Topic; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors
D000900:Anti-Bacterial Agents