title: Supraciliary wrinkles and botulinum toxin A.
abstract: BACKGROUND
  Injection of botulinum toxin into certain areas of face that carry a high risk of ptosis (danger zone) needs caution in application. An example is the lateral forehead, particularly the lower portion.
  
  
  OBJECTIVE
  In this study, we evaluated the efficacy and safety of treating supraciliary wrinkles in the lower lateral forehead by injections of botulinum toxin at the temporal hairline, keeping a reasonable distance from danger zone.
  
  
  METHODS
  In this randomized clinical trial, 40 women (mean age 35 years) were selected and divided into two groups, A and B. both groups were treated with botulinum toxin to treat wrinkles in the frown area, as well as frontal lines and lateral canthus lines. Group B received extra injections at each temporal line for treatment of supraciliary wrinkles.
  
  
  RESULTS
  There was a significant difference in total wrinkle number and mean number of wrinkles between the two groups after injections (paired t-test, P < 0.01). No ptosis was seen in either group.
  
  
  CONCLUSIONS
  Injection of botulinum toxin type A through the temporal hairline to correct supraciliary wrinkles seems to be safe and effective.
authors.affiliation: Skin Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: F
authors.initials: F
authors.lastname: Ghalamkarpour
authors.forename: R M
authors.initials: RM
authors.lastname: Robati
authors.forename: F
authors.initials: F
authors.lastname: Aryanejad
authors.forename: P
authors.initials: P
authors.lastname: Toossi
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D005546:Forehead / Q000473:pathology; D006801:Humans; D007273:Injections, Intramuscular; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D015595:Skin Aging / Q000187:drug effects*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A