title: Transient cocaine-associated behavioral symptoms rated with a new instrument, the scale for assessment of positive symptoms for cocaine-induced psychosis (SAPS-CIP).
abstract: Chronic use of cocaine is associated with a variety of behavioral symptoms. The current report describes the assessment of cocaine-related behavioral symptoms (CRB) using the Scale for Assessment of Positive Symptoms of Cocaine-Induced Psychosis (SAPS-CIP). The CRB section, one of the three domains in the SAPS-CIP, consists of sub-domains, including Aggressive/Agitated Behavior, Repetitive/Stereotyped Behavior, and Unusual Social or Sexual Behavior. Severity scores are assigned according to operational criteria, and range from 0 (not present) to 5 (severe). We interviewed 261 unrelated cocaine-abusing adults using the SAPS-CIP, and 243 of them met criteria for inclusion in the study. The proportion of subjects endorsing different classes of CRBs varied across categories, with 109 of 243 (44.9%) subjects reporting aggressive and agitated behaviors, 180 subjects (74.1%) repetitive/stereotyped behaviors, and 192 (79.0%) unusual social/sexual behaviors. A substantial minority of the subjects (10.3-25.1%) reported that they experienced marked-to-severe behavioral symptoms associated with cocaine use. The proportions of subjects endorsing CRB did not differ by ethnic/racial group or by sex. Correlations among the different domains of CRB were strong, but behaviors rated in the CRB section were less well correlated with psychotic symptoms, which were rated in the hallucination and delusion sections of the instrument. A variety of CRBs are common in cocaine-dependent subjects, and many of these are highly intercorrelated. CRBs also correlate with hallucinations and delusions induced by cocaine, but to a lesser degree. Our findings suggest that there may be some common vulnerability factors that contribute to both cocaine-induced psychosis and CRBs.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, West Haven, Connecticut, USA. jcubells@genetics.emory.edu
authors.forename: Yi-lang
authors.initials: YL
authors.lastname: Tang
authors.forename: Henry R
authors.initials: HR
authors.lastname: Kranzler
authors.forename: Joel
authors.initials: J
authors.lastname: Gelernter
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Farrer
authors.forename: Deborah
authors.initials: D
authors.lastname: Pearson
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Cubells
mesh_terms: D000328:Adult; D001526:Behavioral Symptoms / Q000175:diagnosis*; D019970:Cocaine-Related Disorders / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007406:Interview, Psychological / Q000379:methods*; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000150:complications / Q000175:diagnosis*; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000150:complications