title: Synthesis and evaluation of a thio analogue of duocarmycin SA.
abstract: The design, synthesis, and preliminary evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]thieno[3,2-e]indol-4-one-6-carboxylate (CTI) derivatives are detailed representing a single atom change (N to S) embedded in the duocarmycin SA alkylation subunit.
authors.affiliation: Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Karen S
authors.initials: KS
authors.lastname: MacMillan
authors.forename: James P
authors.initials: JP
authors.lastname: Lajiness
authors.forename: Carlota Lopez
authors.initials: CL
authors.lastname: Cara
authors.forename: Romeo
authors.initials: R
authors.lastname: Romagnoli
authors.forename: William M
authors.initials: WM
authors.lastname: Robertson
authors.forename: Inkyu
authors.initials: I
authors.lastname: Hwang
authors.forename: Pier Giovanni
authors.initials: PG
authors.lastname: Baraldi
authors.forename: Dale L
authors.initials: DL
authors.lastname: Boger
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis / Q000737:chemistry*; D000080890:Duocarmycins; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D000080890:Duocarmycins; D007211:Indoles; D011758:Pyrroles; D013438:Sulfhydryl Compounds; D013876:Thiophenes; C066098:duocarmycin SA