title: Dopamine agonist-induced antecollis in Parkinson's disease.
abstract: Few cases of dopamine agonist-induced antecollis in Parkinson's disease (PD) have been reported. Literature review of 16 PD patients including our 3 cases with dopamine agonist-induced antecollis showed predominance of (1) Japanese, (2) women, and (3) Hoehn-Yahr stage of >or=3. We experienced three Japanese PD patients who subacutely exhibited antecollis following increased dopamine agonist dose that improved just after withdrawal of the agonist. One patient developed antecollis during increasing pramipexole dose in combination with cabergoline. Antecollis in another patient appeared during increasing pramipexole dose; it worsened after substituting pergolide for pramipexole, but improved after withdrawal of pergolide. Our cases indicate that there is no specific dopamine agonist causing antecollis, and it is possibly caused by a number of single dopamine agonists or a combination of them. Dopamine agonist-induced antecollis should be considered when encountering antecollis in PD patients being treated with dopamine agonists and withdrawal of the agonist can improve symptoms.
authors.affiliation: Department of Neurology, Matsudo Municipal Hospital, Chiba, Japan. a-uzimp1204@graduate.chiba-u.jp
authors.forename: Akiyuki
authors.initials: A
authors.lastname: Uzawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mori
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Kojima
authors.forename: Satsuki
authors.initials: S
authors.lastname: Mitsuma
authors.forename: Yukari
authors.initials: Y
authors.lastname: Sekiguchi
authors.forename: Toshihide
authors.initials: T
authors.lastname: Kanesaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwabara
mesh_terms: D000328:Adult; D000368:Aged; D018491:Dopamine Agonists / Q000009:adverse effects* / Q000627:therapeutic use; D004409:Dyskinesia, Drug-Induced / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009334:Neck Muscles / Q000503:physiopathology*; D010300:Parkinson Disease / Q000188:drug therapy
chemical_list: D018491:Dopamine Agonists