title: Prevention of antipsychotic-induced weight gain with early behavioural intervention in first-episode psychosis: 2-year results of a randomized controlled trial.
abstract: While weight-management interventions are effective in attenuating antipsychotic-induced weight, there is no available evidence on their long-term effectiveness. This study sought to investigate the 2-year effects of an early behavioural intervention (EBI) designed to prevent antipsychotic-induced weight gain in first-episode psychosis (FEP) patients. Sixty-one FEP patients were randomized to receive either EBI or treatment-as-usual. Intention-to-treat and observed-cases analysis showed that patients in the EBI group gained significantly less weight than those allocated to routine care at intervention completion (3-month follow-up) with treatment effects maintained over 3months. Differences between groups were no longer significant by 12months. Weight-management interventions may need to be offered for longer periods to maintain preventative effects. Alternatively, booster sessions may need to be regularly delivered after intervention completion.
authors.affiliation: Marques de Valdecilla Public Foundation-Research Institute (FMV-IFIMAV), Santander, Spain. malvarez@unimelb.edu.au
authors.forename: Mario
authors.initials: M
authors.lastname: Alvarez-Jiménez
authors.forename: Obdulia
authors.initials: O
authors.lastname: Martínez-García
authors.forename: Rocío
authors.initials: R
authors.lastname: Pérez-Iglesias
authors.forename: Mari Luz
authors.initials: ML
authors.lastname: Ramírez
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Vázquez-Barquero
authors.forename: Benedicto
authors.initials: B
authors.lastname: Crespo-Facorro
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy / Q000534:rehabilitation*; D016037:Single-Blind Method; D015430:Weight Gain / Q000502:physiology*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents