title: First identification of the neurotoxin homoanatoxin-a from mats of Hydrocoleum lyngbyaceum (marine cyanobacterium) possibly linked to giant clam poisoning in New Caledonia.
abstract: We report the first identification of homoanatoxin-a from benthic marine cyanobacteria (Hydrocoleum lyngbyaceum) samples collected in Lifou (Loyalty Islands, New Caledonia), where cases of giant clams (Tridacna maxima) intoxications were recorded during a severe ciguatera fish poisoning outbreak. Homoanatoxin-a was also detected in extracts of giant clams harvested in the surroundings of the contaminated area suggesting the possible link between these poisoning events and the occurrence of potentially neurotoxic Hydrocoleum.
authors.affiliation: Unité des Cyanobactéries (CNRS URA 2172), Institut Pasteur, Paris Cedex 15, France.
authors.forename: Annick
authors.initials: A
authors.lastname: Méjean
authors.forename: Caroline
authors.initials: C
authors.lastname: Peyraud-Thomas
authors.forename: Anne Sophie
authors.initials: AS
authors.lastname: Kerbrat
authors.forename: Stjepko
authors.initials: S
authors.lastname: Golubic
authors.forename: Serge
authors.initials: S
authors.lastname: Pauillac
authors.forename: Mireille
authors.initials: M
authors.lastname: Chinain
authors.forename: Dominique
authors.initials: D
authors.lastname: Laurent
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000032:analysis* / Q000737:chemistry; D001483:Base Sequence; D049872:Bivalvia / Q000382:microbiology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000032:analysis* / Q000737:chemistry; D036841:Ciguatera Poisoning / Q000453:epidemiology*; D000458:Cyanobacteria / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008386:Marine Biology; D008969:Molecular Sequence Data; D009510:New Caledonia / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D012343:RNA, Transfer / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
chemical_list: D001427:Bacterial Toxins; D019086:Bridged Bicyclo Compounds, Heterocyclic; C524097:homoanatoxin-a; D012343:RNA, Transfer