Comparison of antidepressant effects of azafan, tianeptine, and paroxetine.
Antidepressant activity of Russian product Azafen (pipofezine) and foreign products Paroxetine and Tianepine was compared using behavioral despair test (Porsolt test) and forced swimming test in a container with wheels (Nomura). Azafen significantly shortened the duration of depressive state in both tests. The results suggest that Azafen exhibits pronounced antidepressant activity, superior to that of the reference drugs.
Aleeva
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GN
Laboratory for Creation, Testing, Distribution, Manufacturing, and Marketing of Drugs, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Russia. niipharm@mail.ru
Molodavkin
G M
GM
Voronina
T A
TA
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D010078:Oxazines / Q000494:pharmacology*; D017374:Paroxetine / Q000494:pharmacology*; D051381:Rats; D013841:Thiazepines / Q000494:pharmacology*
D000928:Antidepressive Agents; D010078:Oxazines; D013841:Thiazepines; C050504:tianeptine; C100161:azaphen; D017374:Paroxetine