Novel approaches to vaccination against the feline immunodeficiency virus.
Inadequate antigen presentation and/or suboptimal immunogenicity are considered major causes in the failure of human immunodeficiency vaccine to adequately protect against wild-type virus. Several approaches have been attempted to circumvent these hurdles. Here we reviewed some recent vaccinal strategies tested against the feline immunodeficiency virus and focused on: (i) improving antigen presentation by taking advantage of the exquisite ability of dendritic cells to process and present immunogens to the immune system; (ii) boosting immune responses with vaccinal antigens presented in a truly native conformation by the natural target cells of infection. Significance of the studies, possible correlates of protection involved, and implications for developing anti-human immunodeficiency virus vaccines are discussed.
Pistello
Mauro
M
Retrovirus Center and Virology Section, Department of Experimental Pathology, University of Pisa, Pisa, Italy. pistello@biomed.unipi.it
Conti
Francesca
F
Vannucci
Laura
L
Freer
Giulia
G
D056704:Adaptive Immunity / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D002371:Cat Diseases / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D002415:Cats / Q000276:immunology / Q000821:virology; D016207:Cytokines / Q000627:therapeutic use; D016181:Feline Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control; D016089:Immunodeficiency Virus, Feline / Q000276:immunology*; D016180:Lentivirus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D014765:Viral Vaccines / Q000276:immunology / Q000627:therapeutic use*
D000914:Antibodies, Viral; D016207:Cytokines; D014765:Viral Vaccines