Preview. Inhibition of Tgf-beta signaling improves mouse fibroblast reprogramming.
Circumventing genomic modification in induced pluripotent stem cell (iPSC) derivation is a clear requirement to realize safe clinical applications. In this issue of Cell Stem Cell, Ichida et al., (2009) describe a small molecule capable of replacing Sox2, offering insight into the reprogramming process.
Woltjen
Knut
K
Ontario Human Induced Pluripotent Stem Cell Facility, Toronto, Canada. woltjen@lunenfeld.ca
Stanford
William L
WL