title: Staging of laryngeal cancer using 64-channel multidetector row CT: comparison of standard neck CT with dedicated breath-maneuver laryngeal CT.
abstract: OBJECTIVE
  With a 64-channel multidetector row CT, imaging acquisition during speech, swallowing, or phonation has become feasible. However, the actual benefit of these additional focused images should be critically evaluated with respect to radiation dose. The purpose of this study was to determine if dedicated laryngeal CT using breath-holding and straw-blowing improved the accuracy of TNM-staging for patients with biopsy-proved laryngeal carcinomas in comparison with a standard neck CT.
  
  
  METHODS
  A total of 27 patients underwent a standard neck CT and a laryngeal CT with additional images acquired while patients held their breath or blew through a straw. Two radiologists interpreted the neck CT and later the laryngeal CT and assigned a TNM-stage for each case. These interpretations were compared with a TNM-stage determined by surgery and/or clinical examination for the individual patients. The accuracy of standard neck CT was compared with the accuracy of laryngeal CT.
  
  
  RESULTS
  The overall accuracy was not significantly different between standard neck CT and the additional laryngeal CT and was, in fact, lower in cases with additional larynx images. The accuracy of staging was slightly improved with the additional laryngeal CT for glottic cancers; however, it was decreased for supraglottic cancers. The accuracy of a dichotomous diagnosis of early-versus-advanced-stage cancer was 0.86 for the standard neck CT and 0.80 for the laryngeal CT. The readers' confidence levels did not improve with the use of the additional images.
  
  
  CONCLUSIONS
  In the era of isovoxel multidetector CT technology and judicious monitoring of radiation dose, a standard neck CT with coronal and sagittal reformats should suffice for the staging of laryngeal cancer.
authors.affiliation: Department of Radiology, University of Washington, Seattle, Washington 98195-7115, USA.
authors.forename: K
authors.initials: K
authors.lastname: Gilbert
authors.forename: R W
authors.initials: RW
authors.lastname: Dalley
authors.forename: N
authors.initials: N
authors.lastname: Maronian
authors.forename: Y
authors.initials: Y
authors.lastname: Anzai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D005931:Glottis / Q000000981:diagnostic imaging; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D007830:Larynx / Q000000981:diagnostic imaging; D008297:Male; D009333:Neck / Q000000981:diagnostic imaging; D009367:Neoplasm Staging / Q000379:methods / Q000592:standards* / Q000706:statistics & numerical data; D015588:Observer Variation; D015203:Reproducibility of Results; D015656:Respiratory Mechanics; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000592:standards* / Q000706:statistics & numerical data