The dosage compensation complex shapes the conformation of the X chromosome in Drosophila.
The dosage compensation complex (DCC) in Drosophila globally increases transcription from the X chromosome in males to compensate for its monosomy. We discovered a male-specific conformation of the X chromosome that depends on the associations of high-affinity binding sites (HAS) of the DCC. The core DCC subunits MSL1-MSL2 are responsible for this male-specific organization. Contrary to emerging concepts, we found that neither DCC assembly nor the conformation of the male X chromosome are influenced by nuclear pore components. We propose that nuclear organization of HAS is central to the faithful distribution of the DCC along the X chromosome.
Grimaud
Charlotte
C
Adolf-Butenandt-Institute and Centre for Integrated Protein Science (CiPSM), Ludwig-Maximilians-University, 80336 Munich, Germany.
Becker
Peter B
PB
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D004303:Dosage Compensation, Genetic; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics*; D047108:Embryonic Development; D007399:Interphase / Q000235:genetics; D008297:Male; D011485:Protein Binding; D014960:X Chromosome / Q000737:chemistry* / Q000235:genetics*
D029721:Drosophila Proteins