Low prevalence of HIV type 1 drug resistance mutations in untreated, recently infected patients from Burkina Faso, Côte d'Ivoire, Senegal, Thailand, and Vietnam: the ANRS 12134 study.
The frequency of transmitted HIV drug resistance (HIVDR) was evaluated in the context of rapid scale-up of antiretroviral treatment in Thailand, Vietnam, Burkina Faso, Côte d'Ivoire, and Senegal by using an adaptation of the WHO generic protocol of the HIV Drug Resistance Threshold Survey (HIVDR-TS) for sample collection and classification. Resistance-associated mutations were interpreted using the 2009 WHO list for epidemiological surveys. We included 266 subjects from the five study sites. Of the 266 RT and PR sequences analyzed, two from Vietnam harbored virus with major drug resistance mutations (G190A in RT for one individual and M46I in PR for the second individual). Phylogenetic analysis revealed that CRF01_AE predominates (>90%) in Thailand and Vietnam. CRF02 (>65%) cocirculates with other HIV-1 variants in Senegal and Côte d'Ivoire. The prevalence of HIVDRM is scored as low (< or = 5%) in all the five sites for the three drug classes analyzed. A continuous population survey for HIVDRM will provide a rational basis for maintaining or changing the current first line regimen in these countries.
Ayouba
Ahidjo
A
UMR145, IRD and University of Montpellier 1, Montpellier, France. ahidjo.ayouba@mpl.ird.fr
Lien
Truong T X
TT
Nouhin
Janin
J
Vergne
Laurence
L
Aghokeng
Avelin Fobang
AF
Ngo-Giang-Huong
Nicole
N
Diop
Halimatou
H
Kane
Coumba Touré
CT
Valéa
Diane
D
Rouet
François
F
Joulia-Ekaza
Dominique
D
Toni
Thomas D'Aquin
TD
Nerrienet
Eric
E
Ngole
Eitel Mpoudi
EM
Delaporte
Eric
E
Costagliola
Dominique
D
Peeters
Martine
M
Chaix
Marie-Laure
ML
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D002050:Burkina Faso / Q000453:epidemiology; D007560:Cote d'Ivoire / Q000453:epidemiology; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology; D016333:HIV Protease / Q000235:genetics; D054303:HIV Reverse Transcriptase / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D010802:Phylogeny; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology; D015995:Prevalence; D012675:Senegal / Q000453:epidemiology; D017422:Sequence Analysis, DNA; D013785:Thailand / Q000453:epidemiology; D014744:Vietnam / Q000453:epidemiology; D055815:Young Adult
D019380:Anti-HIV Agents; C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase; D016333:HIV Protease