Asymmetric construction of quaternary stereocenters by direct organocatalytic amination of 3-substituted oxindoles.
Quinidine derivative (QD)(2)PYR was found to catalyze the asymmetric direct amination of unprotected prochiral 3-oxindole with DIAD to construct quaternary stereocenters at the C3 position with excellent enantioselectivity.
Qian
Zi-Qing
ZQ
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, PR China.
Zhou
Feng
F
Du
Tai-Ping
TP
Wang
Bo-Lun
BL
Ding
Miao
M
Zhao
Xiao-Li
XL
Zhou
Jian
J
D000586:Amination; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D000078183:Oxindoles; D013237:Stereoisomerism
D000588:Amines; D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole