title: [Perioperative antibiotics effectiveness on conjunctival flora and microbial sensitivity].
abstract: OBJECTIVE
  To compare the affect upon bacterial flora found in the conjunctival sacs and the microbial sensitivity of a gatifloxacin (GFLX) ophthalmic solution prospectively with two instillation method groups.
  
  
  METHODS
  In one group (group A) GFLX solution was instilled postoperatively eight times/day for 2 days and subsequently four times/day for 12 days. In the other group (group B) the solution was instilled four times/day for 28 days. We investigated bacterial flora in the conjunctival sacs of patients who were to undergo cataract surgery, and tested for microbial sensitivity.
  
  
  RESULTS
  There was no significant difference in the detection rate of bacterial flora in the conjunctival sacs. One bacterial isolate resistant to LVFX was identified in group A, and one resistant to GFLX and LVFX in group B.
  
  
  CONCLUSIONS
  There is a possibility that the application of topical antibiotics may have little influence on positive culture. However, the occurrence of a resistance to GFLX indicates that the aimless use of antibiotics should be avoided during ophthalmic perioperative periods.
authors.affiliation: Department of Clinical Neuroscience, Visual Function and Science, University of the Ryukyus, Faculty of Medicine, Okinawa-ken, Japan. yoshikuni-arakaki@earth.ocn.ne.jp
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Arakaki
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Hayakawa
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Mori
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kojima
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Masahara
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Matsushita
authors.forename: Yosai
authors.initials: Y
authors.lastname: Mori
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Eguchi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D019072:Antibiotic Prophylaxis; D001419:Bacteria / Q000187:drug effects*; D003228:Conjunctiva / Q000382:microbiology*; D024841:Fluoroquinolones / Q000008:administration & dosage* / Q000494:pharmacology*; D000077734:Gatifloxacin; D006801:Humans; D008826:Microbial Sensitivity Tests; D019990:Perioperative Care
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D000077734:Gatifloxacin