title: PACEMAKERS IN NITELLA : II. ARRHYTHMIA AND BLOCK.
abstract: Many forms of irregular rhythm and of partial block occurring in the vertebrate heart can be duplicated in Nitella. In order to observe these phenomena the cells of Nitella are kept for 6 weeks or more in a nutrient solution. They are then exposed for 3 hours or less to 0.01 M NaCl, NaSCN, or guanidine chloride, which reduce the time required for the action current to about 1 second (the normal time is 15 to 30 seconds). A pacemaker is established at one end of the cell by placing it in contact with 0.01 M KCl. This produces action currents at the rate of about 1 a second. Apparently some parts of the cell are unable to follow this rapid pace and hence fall into irregular rhythms (arrhythmia) and fail to register all the impulses (partial block).
authors.affiliation: Laboratories of The Rockefeller Institute for Medical Research.
authors.forename: W J
authors.initials: WJ
authors.lastname: Osterhout
authors.forename: S E
authors.initials: SE
authors.lastname: Hill