Autoimmune polyglandular syndrome type 2 with myasthenia gravis crisis.
We describe a rare case of autoimmune polyglandular syndrome type 2 initially presenting as Addison disease and autoimmune thyroid disease, with subsequent development of autoimmune hepatitis and myasthenia gravis (MG) crisis in a Japanese woman. MG improved with oral prednisolone followed by plasmapheresis for immunoadsorption; thymectomy was not performed. Conventional treatment for MG was effective and safe in this case, in which there was positivity for human leukocyte antigen A23, B52, B62, DR11, and DR15.
Konno
Shingo
S
Division of Neurology, and daggerDepartment of Internal Medicine, Division of Diabetes, Toho University Ohashi Medical Center, Tokyo, Japan. d500372@oha.toho-u.ac.jp
Ichijo
Takamasa
T
Murata
Mayumi
M
Toda
Takahiro
T
Nakazora
Hiroshi
H
Nomoto
Nobuatsu
N
Sugimoto
Hideki
H
Nemoto
Hiroshi
H
Kurihara
Teruyuki
T
Wakata
Nobuo
N
Fujioka
Toshiki
T
D000368:Aged; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D009157:Myasthenia Gravis / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D010956:Plasmapheresis / Q000379:methods; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D011239:Prednisolone / Q000627:therapeutic use; D013934:Thymectomy / Q000379:methods
D005938:Glucocorticoids; D011239:Prednisolone