Sleep disorders and their management in patients with COPD.
Chronic obstructive pulmonary disease (COPD) is a prevalent progressive condition that adversely affects quality of life and sleep. Patients with COPD suffer from variety of sleep disorders including insomnia, sleep disordered breathing and restless leg syndrome. The sleep disorders in COPD patients may stem from poor control of primary disease or due to side effects of pharmacotherapy. Thus, optimization of COPD therapy is the main step in treating insomnia in these patients. Further, pharmacotherapy of sleep disorders may result in respiratory depression and related complications. Therefore, clear understanding of respiratory physiology during transition from wakefulness to sleep and during various stages of sleep plays an important role in therapies that are recommended in patients with significant airway obstruction. In this publication, we review respiratory physiology as it relates to sleep and discuss sleep disorders and their management in patients with COPD.
Sharafkhaneh
Amir
A
Baylor College of Medicine, Sleep Disorders and Research Center, Michael E. DeBakey VA Medical Center, Houston TX, USA. amirs@bcm.tmc.edu
Jayaraman
Gnananandh
G
Kaleekal
Thomas
T
Sharafkhaneh
Hossein
H
Hirshkowitz
Max
M
D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D011788:Quality of Life; D012143:Respiratory Physiological Phenomena; D012148:Restless Legs Syndrome / Q000209:etiology; D012891:Sleep Apnea Syndromes / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D007319:Sleep Initiation and Maintenance Disorders / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D012894:Sleep Stages / Q000502:physiology