title: Activation of alpha-latrotoxin receptors in neuromuscular synapses leads to a prolonged splash acetylcholine release.
abstract: The mechanisms of acetylcholine release in presynaptic terminals of motoneurons induced by mutant alpha-latrotoxin (LT(N4C)) were analyzed. In contrast to wild-type alpha-latrotoxin that causes both continuous and splash secretion of acetylcholine and necessarity block neuromuscular transmission, LT(N4C) causes only splash release lasting over many hours. Thus, activation of alpha-latrotoxin receptors controls long-lasting enhanced secretion of acetylcholine.
authors.affiliation: Department of Cell and Molecular Biology, Imperial College, London, U.K.
authors.forename: V G
authors.initials: VG
authors.lastname: Lelyanova
authors.forename: D
authors.initials: D
authors.lastname: Thomson
authors.forename: R R
authors.initials: RR
authors.lastname: Ribchester
authors.forename: E A
authors.initials: EA
authors.lastname: Tonevitsky
authors.forename: Y A
authors.initials: YA
authors.lastname: Ushkaryov
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D004594:Electrophysiology; D005089:Exocytosis; D051379:Mice; D009154:Mutation; D018000:Receptors, Peptide / Q000378:metabolism* / Q000502:physiology*; D013111:Spider Venoms / Q000235:genetics / Q000378:metabolism; D013569:Synapses / Q000378:metabolism*
chemical_list: D018000:Receptors, Peptide; D013111:Spider Venoms; C034800:alpha-latrotoxin receptor; C020763:alpha-latrotoxin; D000109:Acetylcholine