title: Spindle cell/pleomorphic lipoma of the oral cavity.
abstract: We herein report a rare case of a lipomatous tumor of the buccal mucosa, showing intermediate morphological features between spindle cell and pleomorphic lipomas, for which the term spindle cell/pleomorphic lipoma is proposed. The presence of multinucleated floretlike cells may pose differential diagnostic problems, especially with spindle cell variant of well-differentiated liposarcoma. Morphological features helpful in the distinction between these tumors are emphasized. Although androgen receptors have been documented in most spindle cell lipomas, suggesting a potential pathogenetic role of sex steroid hormones, no immunoreactivity for androgen, estrogen, and progesterone receptors was obtained in our case. These findings would suggest a different pathogenetic pathway in spindle cell/pleomorphic lipoma of the oral cavity.
authors.affiliation: Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Catania, Italy.
authors.forename: Giada
authors.initials: G
authors.lastname: Vecchio
authors.forename: Paolo
authors.initials: P
authors.lastname: Amico
authors.forename: Rosario
authors.initials: R
authors.lastname: Caltabiano
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Colella
authors.forename: Salvatore
authors.initials: S
authors.lastname: Lanzafame
authors.forename: Gaetano
authors.initials: G
authors.lastname: Magro
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008067:Lipoma / Q000473:pathology*; D008080:Liposarcoma / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000473:pathology*; D011944:Receptors, Androgen / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis
chemical_list: D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone