The pathophysiology of septic shock.
There is a profound cellular dysfunction in sepsis, that clinically manifests as a continuum from simple, uncomplicated sepsis to severe sepsis, and finally to septic shock. Septic shock remains a significant challenge for clinicians. Recent advances in cellular and molecular biology have significantly improved our understanding of its pathogenetic mechanisms. These improvements will translate to better care and improved outcomes for these patients.
Nduka
O Okorie
OO
Division of Critical Care Medicine, Department of Internal Medicine, Cooper University Hospital, Camden, NJ, USA. Okorie-Okorie@CooperHealth.edu
Parrillo
Joseph E
JE
D015870:Gene Expression / Q000502:physiology; D044404:Genomic Islands / Q000502:physiology; D024002:HMGB Proteins / Q000502:physiology; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000502:physiology; D053038:Quorum Sensing / Q000502:physiology; D051192:Receptors, Pattern Recognition / Q000502:physiology; D012772:Shock, Septic / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*; D013601:T-Lymphocytes / Q000276:immunology; D051193:Toll-Like Receptors / Q000502:physiology; D037521:Virulence Factors / Q000276:immunology / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000502:physiology
D024002:HMGB Proteins; D008263:Macrophage Migration-Inhibitory Factors; D051192:Receptors, Pattern Recognition; D051193:Toll-Like Receptors; D037521:Virulence Factors; D020741:rho GTP-Binding Proteins