Predicting postprandial lipemia in healthy adults and in at-risk individuals with components of the cardiometabolic syndrome.
To determine whether a single-point triglyceride (TG) concentration could estimate the 8-hour postprandial lipemic (PPL) response, men and women performed baseline PPL (n=188) and postexercise PPL (n=92) trials. Correlations were generated between TG concentrations at baseline and at various time points after a high-fat meal vs 8-hour area under the TG curve (TG-AUC) and peak TG level. Stepwise multiple regression and bootstrap simulations using TG level and additional predictor variables of sex, age, percentage of body fat, training status, and maximal oxygen consumption indicated that the 4-hour TG concentrations accounted for >90% of the variance in TG-AUC and peak TG responses during the PPL trials. Equations were confirmed by cross-validation in healthy as well as at-risk individuals with components of the cardiometabolic syndrome. Our data suggest that the 4-hour TG value is highly related to the total 8-hour PPL response and can be used for accurate estimation of PPL in a clinical or research setting.
Rector
R Scott
RS
Department of Nutrition and Exercise Physiology, University of Missouri-Columbia, 65211, USA.
Linden
Melissa A
MA
Zhang
John Q
JQ
Warner
Shana O
SO
Altena
Thomas S
TS
Smith
Bryan K
BK
Ziogas
George G
GG
Liu
Ying
Y
Thomas
Tom R
TR
D000293:Adolescent; D000328:Adult; D001823:Body Composition / Q000502:physiology; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications* / Q000503:physiopathology*; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology; D019518:Postprandial Period / Q000502:physiology*; D011237:Predictive Value of Tests; D012044:Regression Analysis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D014280:Triglycerides