title: Intraspecific polymorphism to interspecific divergence: genetics of pigmentation in Drosophila.
abstract: Genetic changes contributing to phenotypic differences within or between species have been identified for a handful of traits, but the relationship between alleles underlying intraspecific polymorphism and interspecific divergence is largely unknown. We found that noncoding changes in the tan gene, as well as changes linked to the ebony gene, contribute to pigmentation divergence between closely related Drosophila species. Moreover, we found that alleles linked to tan and ebony fixed in one Drosophila species also contribute to variation within another species, and that multiple genotypes underlie similar phenotypes even within the same population. These alleles appear to predate speciation, which suggests that standing genetic variation present in the common ancestor gave rise to both intraspecific polymorphism and interspecific divergence.
authors.affiliation: Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA. wittkopp@umich.edu
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Wittkopp
authors.forename: Emma E
authors.initials: EE
authors.lastname: Stewart
authors.forename: Lisa L
authors.initials: LL
authors.lastname: Arnold
authors.forename: Adam H
authors.initials: AH
authors.lastname: Neidert
authors.forename: Belinda K
authors.initials: BK
authors.lastname: Haerum
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Thompson
authors.forename: Saleh
authors.initials: S
authors.lastname: Akhras
authors.forename: Gabriel
authors.initials: G
authors.lastname: Smith-Winberry
authors.forename: Laura
authors.initials: L
authors.lastname: Shefner
mesh_terms: D000483:Alleles; D000818:Animals; D030801:Animals, Genetically Modified; D001483:Base Sequence; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics* / Q000378:metabolism; D003433:Crosses, Genetic; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D004330:Drosophila / Q000145:classification / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D005786:Gene Expression Regulation; D017344:Genes, Insect; D049810:Genetic Speciation; D005838:Genotype; D007438:Introns; D008297:Male; D008969:Molecular Sequence Data; D010641:Phenotype; D010858:Pigmentation / Q000235:genetics*; D011110:Polymorphism, Genetic; D040641:Quantitative Trait Loci; D013045:Species Specificity
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C116191:e protein, Drosophila; C431070:t protein, Drosophila