The bladder extracellular matrix. Part II: regenerative applications.
Bladder regeneration is a long-sought goal that could provide alternatives to cystoplasty using non-urological tissues. Regeneration might be achieved in different ways, such as seeding matrices with stem cells or conventional cells, or repopulation of the matrix by the body's own reservoir of cells. Consideration of how the extracellular matrix directs cell behavior will be crucial to the success of regenerative therapies.
Aitken
Karen J
KJ
Division of Developmental & Stem Cell Biology, The Hospital For Sick Children, University of Toronto, ON, Canada.
Bägli
Darius J
DJ
D000818:Animals; D001696:Biomechanical Phenomena; D005109:Extracellular Matrix / Q000502:physiology*; D006801:Humans; D012038:Regeneration; D033581:Stem Cell Transplantation; D001743:Urinary Bladder / Q000502:physiology*