title: [Two cases of serious hepatic injury caused by antithyroid drugs].
abstract: We present two cases of severe hepatotoxicity caused by antithyroid drugs in women with Graves disease. The first medication in both cases was methimazole replaced by propylhiouracil due to intolerance. The main symptom was jaundice lasting about 2 months. As a first step in the treatment we terminated the antithyroid drug administration and introduced prednisone and ursodesoksycholic acid therapy. The termination of thyrotoxicosis by means of 131 I administration had also positive influence on the course of disease. In summary we emphasise the significance of prompt discontinuation of antithyroid drug once toxic symptoms appeared and avoid replacement one thyrostatic drug for another in fovour of radioiodine treatment.
authors.affiliation: Oddział Chorób Wewnetznych, Nefrologii i Endokrynologii z Pracownia Medycyny Nuklearnej, Szpital Wojewódzki Nr 2., Rzeszów. mgrzywa@szpital2.rzeszow.pl
authors.forename: Marek
authors.initials: M
authors.lastname: Grzywa
authors.forename: Renata
authors.initials: R
authors.lastname: Orłowska-Florek
authors.forename: Anna
authors.initials: A
authors.lastname: Grzywa-Celińska
mesh_terms: D013956:Antithyroid Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D006111:Graves Disease / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D007565:Jaundice / Q000139:chemically induced; D008713:Methimazole / Q000009:adverse effects; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D011441:Propylthiouracil / Q000009:adverse effects*
chemical_list: D013956:Antithyroid Agents; D007457:Iodine Radioisotopes; D008713:Methimazole; D011441:Propylthiouracil; D011241:Prednisone