title: Outcomes after liver transplant in patients aged 70 years or older compared with those younger than 60 years.
abstract: OBJECTIVE
  To compare mortality, graft loss, and postoperative complications after liver transplant in older patients (> or =70 years) with those in younger patients (<60 years).
  
  
  METHODS
  Outcomes for 42 patients aged 70 years or older who underwent liver transplant were compared with those of 42 matched controls younger than 60 years. All patients underwent transplants between March 19, 1998, and May 7, 2004. Information was collected on patient characteristics, comorbid conditions, laboratory results, donor and operative variables, medical and surgical complications, and mortality and graft loss.
  
  
  RESULTS
  Preoperative characteristics were similar across age groups, except for creatinine (P=.01) and serum albumin (P=.03) values, which were higher in older patients, and an earlier year of transplant in younger patients (P<.001). Intraoperatively, older patients required more erythrocyte transfusions (P=.04) and more intraoperative fluids (P=.001) than did younger patients. Postoperatively, bilirubin level (P=.007) and international normalized ratios (P=.01) were lower in older patients, whereas albumin level was higher (P<.001). The median follow-up was 5.1 years (range, 0.1-8.5 years). Compared with younger patients, older patients were not at an increased risk of death (relative risk, 1.00; 95% confidence interval, 0.43-2.31; P>.99) or graft loss (relative risk, 1.17; 95% confidence interval, 0.54-2.52; P=.70). The frequency of other complications did not differ significantly between age groups, although older patients had more cardiovascular complications.
  
  
  CONCLUSIONS
  Five-year mortality and graft loss in older recipients were comparable with those in younger recipients, suggesting that age alone should not exclude older patients from liver transplant.
authors.affiliation: Division of Pulmonary Medicine, Mayo Clinic, Jacksonville, FL 32224, USA. jaduen@mayo.edu
authors.forename: Javier F
authors.initials: JF
authors.lastname: Aduen
authors.forename: Bangarulingam
authors.initials: B
authors.lastname: Sujay
authors.forename: Rolland C
authors.initials: RC
authors.lastname: Dickson
authors.forename: Michael G
authors.initials: MG
authors.lastname: Heckman
authors.forename: Winston R
authors.initials: WR
authors.lastname: Hewitt
authors.forename: Wolf H
authors.initials: WH
authors.lastname: Stapelfeldt
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Steers
authors.forename: Denise M
authors.initials: DM
authors.lastname: Harnois
authors.forename: David J
authors.initials: DJ
authors.lastname: Kramer
mesh_terms: D000046:Academic Medical Centers; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002423:Cause of Death; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D015577:Geriatric Assessment; D006084:Graft Rejection / Q000401:mortality*; D006085:Graft Survival; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D053208:Kaplan-Meier Estimate; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D008910:Minnesota; D011183:Postoperative Complications / Q000401:mortality / Q000503:physiopathology; D011336:Probability; D012189:Retrospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D013530:Surgical Wound Infection / Q000175:diagnosis / Q000401:mortality*; D016896:Treatment Outcome