Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.
McCubrey
James A
JA
East Carolina University, Greenville, NC, USA. mccubreyj@ecu.edu
Abrams
Stephen L
SL
Stadelman
Kristin
K
Chappell
William H
WH
Lahair
Michelle
M
Ferland
Richard A
RA
Steelman
Linda S
LS
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D004351:Drug Resistance / Q000502:physiology*; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism; D009362:Neoplasm Metastasis; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000378:metabolism; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D000970:Antineoplastic Agents; D019869:Phosphatidylinositol 3-Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D020928:Mitogen-Activated Protein Kinases; D051059:PTEN Phosphohydrolase