title: Serum evaluation of soluble interferon-alpha/beta receptor and high-sensitivity C-reactive protein for diagnosis of the patients with gastrointestinal and hepatobiliary-pancreatic cancer.
abstract: Serum soluble interferon-alpha/beta receptor (sIFN-alpha/betaR) and high-sensitivity C-reactive protein (hs-CRP) levels were evaluated in the patients with gastrointestinal and hepatobiliary-pancreatic cancer. We compared the sensitivity and specificity of serum sIFN-alpha/betaR with that of serum hs-CRP and evaluated the two diagnostic parameters in combination. Serum sIFN-alpha/betaR levels were measured in 92 patients and 25 healthy individuals by enzyme-linked immunosorbent assay. The diagnoses were 37 cases of hepatocellular carcinoma, 17 cases of pancreatic cancer, 15 cases of colon cancer, 13 cases of biliary tract cancer, and 10 cases of gastric cancer. Serum levels of sIFN-alpha/betaR and hs-CRP were significantly higher in the patients than in healthy individuals (p<0.05). The optimal cut-off values of sIFN-alpha/betaR and hs-CRP were 3600pg/ml and 0.5microg/ml, respectively. The sensitivity and specificity for these thresholds were 94.6% and 88.0%, whereas positive predictive and negative predictive values were 96.7% and 81.5%. These results suggest that a combination of serum sIFN-alpha/betaR and hs-CRP thresholds may be more reliable diagnostic parameter for gastrointestinal and hepatobiliary-pancreatic cancer.
authors.affiliation: Department of Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan. kota166@clin.med.tokushima-u.ac.jp
authors.forename: Kotaro
authors.initials: K
authors.lastname: Miyake
authors.forename: Satoru
authors.initials: S
authors.lastname: Imura
authors.forename: Masanori
authors.initials: M
authors.lastname: Nishioka
authors.forename: Erdenebulgan
authors.initials: E
authors.lastname: Batmunkh
authors.forename: Koji
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Yasukazu
authors.initials: Y
authors.lastname: Ohmoto
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Shimada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001661:Biliary Tract Neoplasms / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D011237:Predictive Value of Tests; D053633:Receptor, Interferon alpha-beta / Q000097:blood*; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D053633:Receptor, Interferon alpha-beta; D002097:C-Reactive Protein