title: Indolent CD8-positive lymphoid proliferation on the face: part of the spectrum of primary cutaneous small-/medium-sized pleomorphic T-cell lymphoma or a distinct entity?
abstract: We report two cases of a CD8-positive lymphoid proliferation presenting as solitary lesions on the ear and nose, respectively. Histopathologically, both cases were characterized by a diffuse non-epidermotropic dermal proliferation of clonal medium-sized CD8-positive T-lymphocytes with a lymphoblast-like appearance, having cells with large folded nuclei, prominent nucleoli and ample amphophilic or pale eosinophilic cytoplasm. Staging procedures excluded systemic involvement, and both lesions were successfully treated with localised radiotherapy without evidence of recurrence after 12 and 24 months' follow up, respectively. Previously reported cases on the ear had similar clinicopathological and immunophenotypical features, and together raise the possibility of a distinct entity, an indolent CD8-positive lymphoid proliferation.
authors.affiliation: St John's Institute of Dermatology, St Thomas' Hospital, London.
authors.forename: Ravi
authors.initials: R
authors.lastname: Suchak
authors.forename: Simon
authors.initials: S
authors.lastname: O'Connor
authors.forename: Christopher
authors.initials: C
authors.lastname: McNamara
authors.forename: Alistair
authors.initials: A
authors.lastname: Robson
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology*; D002999:Clone Cells; D004273:DNA, Neoplasm / Q000235:genetics; D018572:Disease-Free Survival; D004428:Ear Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics; D006801:Humans; D008221:Lymphoid Tissue / Q000378:metabolism / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy; D016410:Lymphoma, T-Cell, Cutaneous / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm