The prominent role of neutrophils during the initial phase of infection by Leishmania parasites.
Neutrophils are rapidly and massively recruited to the site of Leishmania inoculation, where they phagocytose the parasites, some of which are able to survive within these first host cells. Neutrophils can thus provide a transient safe shelter for the parasites, prior to their entry into macrophages where they will replicate. In addition, neutrophils release and synthesize rapidly several factors including cytokines and chemokines. The mechanism involved in their rapid recruitment to the site of parasite inoculation, as well as the putative consequences of their massive presence on the microenvironment of the focus of infection will be discussed in the context of the development of the Leishmania-specific immune response.
Charmoy
Mélanie
M
WHO Immunology Research and Training Center, Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
Auderset
Floriane
F
Allenbach
Cindy
C
Tacchini-Cottier
Fabienne
F
D000818:Animals; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007107:Immune System; D007891:Leishmania / Q000378:metabolism*; D007896:Leishmaniasis / Q000097:blood* / Q000503:physiopathology*; D008264:Macrophages / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008954:Models, Biological; D009504:Neutrophils / Q000469:parasitology*; D011576:Psychodidae; D013045:Species Specificity
D018925:Chemokines; D016207:Cytokines