title: Crotonkinensins A and B, diterpenoids from the Vietnamese medicinal plant Croton tonkinensis.
abstract: Two new diterpenoids, crotonkinensins A (1) and B (2), were isolated from the leaves of the Vietnamese endemic medicinal plant Croton tonkinensis. Their structures were determined to be 7alpha,10alpha-epoxy-14beta-hydroxygrayanane-1(5),16(17)-dien-2,15-dione (1) and 7alpha,10alpha-epoxy-14beta-hydroxygrayanane-1(2),16(17)-dien-15-one (2) by spectroscopic analysis. Compounds 1 and 2 showed strong anti-inflammatory effects on the LPS-induced COX-2 promoter activity and COX-2 expression in Raw 264.7 cells.
authors.affiliation: College of Pharmacy, Chosun University, 375 Seosuk-dong, Dong-gu, Gwangju 501-759, Republic of Korea.
authors.forename: Phuong-Thien
authors.initials: PT
authors.lastname: Thuong
authors.forename: Trong-Tuan
authors.initials: TT
authors.lastname: Dao
authors.forename: Thi-Hong-Minh
authors.initials: TH
authors.lastname: Pham
authors.forename: Phi-Hung
authors.initials: PH
authors.lastname: Nguyen
authors.forename: Thi-Van-Thu
authors.initials: TV
authors.lastname: Le
authors.forename: Kwang-Youl
authors.initials: KY
authors.lastname: Lee
authors.forename: Won-Keun
authors.initials: WK
authors.lastname: Oh
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029802:Croton / Q000737:chemistry*; D051546:Cyclooxygenase 2 / Q000187:drug effects / Q000235:genetics; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D014744:Vietnam
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D008070:Lipopolysaccharides; C545421:crotonkinensin A; C545422:crotonkinensin B; D051546:Cyclooxygenase 2