[Anti-inflammatory effect of N-stearoylethanolamine in experimental burn injury in rats].
The biochemical mechanisms of anti-inflammatory effect of endocannabinoid congener N-stearoylethanolamine (NSE) was studied on the model of experimental burn in rats. The animals after the thermal burn of the skin received per os during 7 days the water suspension of NSE in a doze 10 mg/kg of body weight. In the other groups of rats the suspension was applied to the wound (the concentration of NSE was 10 mg/ml). It was shown for the first time that NSE accelerated the process of burn wound healing by the inhibition of proinflammatory cytokines (TNFalpha, IL-6) production. NSE caused the normalization of the iNOS and cNOS activity and of nitrite content in plasma, erythrocytes, liver and spleen of rats. NSE also modified the antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase) activity and diminished the level of lipid peroxidation. The discovered anti-inflammatory NSE properties suggest the possibility of its usage for burn treatment.
Hula
N M
NM
Chumak
A A
AA
Berdyshev
A H
AH
Mehed'
O F
OF
Horid'ko
T M
TM
Kindruk
N L
NL
Kosiakova
H V
HV
Zhukov
O D
OD
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy* / Q000201:enzymology / Q000276:immunology / Q000378:metabolism; D002374:Catalase / Q000097:blood / Q000378:metabolism; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D004983:Ethanolamines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005980:Glutathione Reductase / Q000097:blood / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D019001:Nitric Oxide Synthase / Q000378:metabolism; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000201:enzymology / Q000293:injuries / Q000378:metabolism; D013154:Spleen / Q000187:drug effects / Q000201:enzymology; D013229:Stearic Acids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000276:immunology; D014945:Wound Healing / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D004983:Ethanolamines; D015850:Interleukin-6; C408368:N-stearoylethanolamine; D013229:Stearic Acids; D014409:Tumor Necrosis Factor-alpha; D002374:Catalase; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase