title: SimBoolNet--a Cytoscape plugin for dynamic simulation of signaling networks.
abstract: CONCLUSIONS
  SimBoolNet is an open source Cytoscape plugin that simulates the dynamics of signaling transduction using Boolean networks. Given a user-specified level of stimulation to signal receptors, SimBoolNet simulates the response of downstream molecules and visualizes with animation and records the dynamic changes of the network. It can be used to generate hypotheses and facilitate experimental studies about causal relations and crosstalk among cellular signaling pathways.
  
  
  BACKGROUND
  SimBoolNet package (with manual) is freely available at http://www.ncbi.nlm.nih.gov/CBBresearch/Przytycka/SimBoolNet
authors.affiliation: National Center for Biotechnology Information, NLM/NIH, Bethesda, MD, USA. zhengj@ncbi.nlm.nih.gov
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
authors.forename: David
authors.initials: D
authors.lastname: Zhang
authors.forename: Pawel F
authors.initials: PF
authors.lastname: Przytycki
authors.forename: Rafal
authors.initials: R
authors.lastname: Zielinski
authors.forename: Jacek
authors.initials: J
authors.lastname: Capala
authors.forename: Teresa M
authors.initials: TM
authors.lastname: Przytycka
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D008954:Models, Biological; D015233:Models, Statistical; D020543:Proteome / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D012984:Software
chemical_list: D020543:Proteome