title: [Effect of Santalum album on tissue distribution of danshensu in rabbits by HPLC].
abstract: OBJECTIVE
  To investigate the influence of Shi herb (Santalum album, SA) to the tissue distribution of danshensu (DSS) which is the main hydrosoluble component of Jun herb (Salvia miltiorrhiza, SM) in rabbits by HPLC.
  
  
  METHODS
  Rabbits were oral administrated decoction of SM and SM-SA, respectively. Perchloric acid (10%) was used to precipitate the tissue samples of rabbits heart, brain, liver, kidney, acetic ether was used to extracte supernatant, and the internal standard was p-hydroxybenzoic acid. The content of DSS of SM in tissues was detected.
  
  
  RESULTS
  The content of DSS reached the highest point close to 50 min in the mentioned tissues. Before and after co-administration, the sequences of average concentration of DSS in tissues were C(kidney) > C(heart) > C(brain) > C(liver) and C(kidney) > C(liver) > C(brain) > C(heart) respectively. Compared with SM administrated singly, the content of DSS in every tissues of co-administration was higher.
  
  
  CONCLUSIONS
  In Danshenyin Formulae, SA can increase concentration of DSS in target tissues significantly, and therefore therapeutic effect of SM for cardiovascular disease is raised.
authors.affiliation: College of Life Science, Northwest University, Xi'an 710069, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yimei
authors.initials: Y
authors.lastname: Tang
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Shixiang
authors.initials: S
authors.lastname: Wang
authors.forename: Minfeng
authors.initials: M
authors.lastname: Fang
authors.forename: Yajun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zheng
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D007773:Lactates / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D008099:Liver / Q000187:drug effects; D011817:Rabbits; D032123:Santalum / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D007773:Lactates; C035055:3,4-dihydroxyphenyllactic acid