How to control miRNA maturation?
In this point of view we discuss the role of co-activators and co-repressors of miRNA precursors maturation, the possibility that their functions are post translationally regulated by different signaling pathways, and their potential role in the miRNA-dependent control of cell proliferation and differentiation.
Trabucchi
Michele
M
Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Briata
Paola
P
Filipowicz
Witold
W
Rosenfeld
Michael G
MG
Ramos
Andres
A
Gherzi
Roberto
R
D002454:Cell Differentiation; D049109:Cell Proliferation; D056970:Co-Repressor Proteins / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D012322:RNA Precursors / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D043244:Ribonuclease III / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology
D056970:Co-Repressor Proteins; D035683:MicroRNAs; D012322:RNA Precursors; D014157:Transcription Factors; C517918:DROSHA protein, human; D043244:Ribonuclease III