title: [Natural interferon alpha (Le-IFNalpha) treatment in patients with thrombocytopenia during chronic HCV infection--our observations].
abstract: The aim of our study was to assess efficacy and safety of antiviral treatment with natural interferon alpha in patients with thrombocytopenia during chronic HCV infection. The study group consisted of 14 patients infected with HCV genotype lb. There were 8 women and 6 men (mean age 50). 11 of these had compensated liver cirrhosis. Three patients had previous reIFN or PegIFN alpha therapy with severe adverse events and lack of sustained viral response (SVR). Sustained viral response was achieved in 4 patients. Only in one case therapy was discontinued due to symptomatic hemorrhagic purpura.
authors.affiliation: Katedra i Klinika Chorób Zakaźnych Uniwersytetu Medycznego w Lublinie. firychjdr@poczta.onet.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Krzowska-Firych
authors.forename: Anna
authors.initials: A
authors.lastname: Przybyła
authors.forename: Roma
authors.initials: R
authors.lastname: Modrzewska
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D013921:Thrombocytopenia / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha