title: Preparation and evaluation of microspheres prepared from novel polyester-ibuprofen conjugates blended with non-conjugated ibuprofen.
abstract: A novel polyester, poly(glycerol-adipate-co-omega-pentadecalactone) (PGA-co-PL), was conjugated with a model drug, ibuprofen, through the free hydroxyl groups of the former and the free carboxyl group of the latter at various levels of substitution. The conjugated material was processed into microspheres by both emulsion solvent evaporation and spray-drying methods. Samples of conjugated material were also blended with non-conjugated drug and the microspheres produced were evaluated by various methods. Morphologically, the microspheres produced were satisfactory. However, there was some initial burst drug release from all samples, probably due to the presence of non-conjugated drug. Subsequent drug release was very slow due to the relative stability of the covalent bonding of the drug-polyester conjugate. Stability tests showed that storage at high relative humidity resulted in increased burst release.
authors.affiliation: School of Pharmacy and Life Sciences, The Robert Gordon University, Aberdeen AB10 1FR, Scotland.
authors.forename: C J
authors.initials: CJ
authors.lastname: Thompson
authors.forename: D
authors.initials: D
authors.lastname: Hansford
authors.forename: S
authors.initials: S
authors.lastname: Higgins
authors.forename: C
authors.initials: C
authors.lastname: Rostron
authors.forename: G A
authors.initials: GA
authors.lastname: Hutcheon
authors.forename: D L
authors.initials: DL
authors.lastname: Munday
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry; D008863:Microspheres; D011091:Polyesters / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D011091:Polyesters; D007052:Ibuprofen