title: THE RELATIONSHIP BETWEEN CHEMICAL STRUCTURE AND THE RESPONSE OF BLOWFLIES TO TARSAL STIMULATION BY ALIPHATIC ACIDS.
abstract: Using the technique of proboscis extension in antennectomized-labellectomized flies, the rejection thresholds of Phormia regina for 18 fatty acids and one mineral acid have been determined. The conclusions reached on the basis of these data may be summarized in the following terms: Tarsal stimulation by acids involves the summation of components from at least two sources. Of these the hydrogen ion is the most important. The other major factor is probably the anion rather than the undissociated acid. The stimulating power of the anions (or free acid molecules) increases with increasing chain length in both the mono- and dicarboxylic series, but the rate of increase decreases as the series is ascended. Acids containing 6 or more carbon atoms are not sufficiently soluble in 0.1 M sucrose to reach the threshold of rejection. Substitution of -H in the acyl grouping by -Cl, -OH, =O or -COOH, the presence of a C=C bond, or a shift from the trans- to the cis- configuration all diminish the effectiveness of the anion (or free acid). But since such alterations also augment the degree of dissociation and consequently the concentration of hydrogen ions, the net result is ordinarily a lowering of threshold in terms of the molar concentration required for rejection.
authors.affiliation: Medical Division, Army Chemical Corps, Edgewood Arsenal, Maryland.
authors.forename: L E
authors.initials: LE
authors.lastname: Chadwick
authors.forename: V G
authors.initials: VG
authors.lastname: Dethier
mesh_terms: D000818:Animals; D004175:Diptera; D005227:Fatty Acids; D007306:Insecticides / Q000494:pharmacology*
chemical_list: D005227:Fatty Acids; D007306:Insecticides