title: [Lymphoproliferative disorders in an inflammatory bowel disease unit].
abstract: BACKGROUND
  The relationship between inflammatory bowel disease (IBD) and lymphoproliferative disorders (LD) has been previously reported.
  
  
  OBJECTIVE
  To establish the local incidence of LD in an IBD unit, and to describe the clinical characteristics of observed cases.
  
  
  METHODS
  All the clinical records of patients with ulcerative colitis (UC) or Crohn's disease (CD) followed-up in a tertiary center were reviewed. In all cases, IBD had been diagnosed according to standard criteria.
  
  
  RESULTS
  Of 911 patients with IBD, we identified seven with lymphoma. Five of the patients were men, four had been diagnosed with UC and three with Crohn's disease. The mean time from IBD to lymphoma diagnosis was 4.82 years (r: 0-20). The mean age at lymphoma diagnosis was 53 years (r: 33-76). Four were colorectal lymphomas. There was only one case of Hodgkin's disease. Five patients had been treated with thiopurines, and four of these had also been treated with biological agents. Three cases were associated with Epstein-Barr (EBV) virus infection. The estimated incidence of LD in these IBD patients was 81.74/100,000/year. After a mean follow-up of 32.3 months (r: 5-57) following the last treatment for LD, all patients except one are in remission.
  
  
  CONCLUSIONS
  The incidence rate of LD was much higher than the expected rate for the general population (81.74 vs. 22). Chronic inflammation, immune-modifying drugs and Epstein Barr virus infection may be implicated in the pathogenesis of this disease.
authors.affiliation: Gastroenterología, Hospital Universitario Ramón y Cajal, Madrid, España. manuelvandomselaar@yahoo.com
authors.forename: Manuel
authors.initials: M
authors.lastname: Van Domselaar
authors.forename: Antonio
authors.initials: A
authors.lastname: López San Román
authors.forename: Mariana
authors.initials: M
authors.lastname: Bastos Oreiro
authors.forename: Elena
authors.initials: E
authors.lastname: Garrido Gómez
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006757:Hospital Units; D006801:Humans; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008232:Lymphoproliferative Disorders / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged