The RGM/DRAGON family of BMP co-receptors.
The BMP signaling pathway controls a number of cell processes during development and in adult tissues. At the cellular level, ligands of the BMP family act by binding a hetero-tetrameric signaling complex, composed of two type I and two type II receptors. BMP ligands make use of a limited number of receptors, which in turn activate a common signal transduction cascade at the intracellular level. A complex regulatory network is required in order to activate the signaling cascade at proper times and locations, and to generate specific downstream effects in the appropriate cellular context. One such regulatory mechanism is the repulsive guidance molecule (RGM) family of BMP co-receptors. This article reviews the current knowledge regarding the structure, regulation, and function of RGMs, focusing on known and potential roles of RGMs in physiology and pathophysiology.
Corradini
Elena
E
Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02472, USA.
Babitt
Jodie L
JL
Lin
Herbert Y
HY
D000818:Animals; D052004:Bone Morphogenetic Protein Receptors / Q000378:metabolism*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000378:metabolism* / Q000502:physiology*; D011485:Protein Binding; D015398:Signal Transduction / Q000502:physiology
D019485:Bone Morphogenetic Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D052004:Bone Morphogenetic Protein Receptors