[Participation of proteolytic enzymes in radiation-induced apoptosis of rat thymocytes].
Participation ofproteolytic enzymes, especially, caspases and calpains in rat's thymocytes under apoptosis induced by X-ray exposure has been investigated. The increase of caspase-3, caspase-6 and calpains activity 30 min and 3 h after irradiation is accompanied by enhancing of the number of cell at early and final stages of apoptosis, which was identified both at the level of plasmatic membrane and at the level of nuclear compartment.
Andriĭchuk
T R
TR
Raksha
N H
NH
Tsudzevych
B O
BO
Ostapchenko
L I
LI
D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D002154:Calpain / Q000378:metabolism; D020169:Caspases / Q000378:metabolism; D002478:Cells, Cultured; D008297:Male; D010447:Peptide Hydrolases / Q000378:metabolism*; D011829:Radiation Dosage; D051381:Rats; D013950:Thymus Gland / Q000166:cytology / Q000201:enzymology / Q000528:radiation effects*; D013997:Time Factors; D014965:X-Rays
D010447:Peptide Hydrolases; D002154:Calpain; D020169:Caspases