GPCR signalling to the translation machinery.
G protein-coupled receptors (GPCRs) are involved in most physiological processes, many of them being engaged in fully differentiated cells. These receptors couple to transducers of their own, primarily G proteins and beta-arrestins, which launch intracellular signalling cascades. Some of these signalling events regulate the translational machinery to fine-tune general cell metabolism or to alter protein expression pattern. Though extensively documented for tyrosine kinase receptors, translational regulation by GPCRs is still poorly appreciated. The objective of this review paper is to address the following questions: i) is there a "GPCR signature" impacting on the translational machinery, and ultimately on the type of mRNA translated? ii) are the regulatory networks involved similar as those utilized by tyrosine kinase receptors? In particular, we will discuss the specific features of translational control mediated by GPCRs and highlight the intrinsic properties of GPCRs these mechanisms could rely on.
Musnier
Astrid
A
BIOS group, INRA, UMR, Unité Physiologie de la Reproduction et des Comportements, Nouzilly, France.
Blanchot
Benoît
B
Reiter
Eric
E
Crépieux
Pascale
P
D000818:Animals; D019390:Arrestins / Q000378:metabolism; D006801:Humans; D014176:Protein Biosynthesis; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D017470:Receptors, Glutamate / Q000378:metabolism; D015398:Signal Transduction; D000071557:beta-Arrestins
D019390:Arrestins; D043562:Receptors, G-Protein-Coupled; D017470:Receptors, Glutamate; D000071557:beta-Arrestins