MRI features in a canine model of ischemic stroke: correlation between lesion volume and neurobehavioral status during the subacute stage.
The purpose of this study was to evaluate the diagnostic value of magnetic resonance imaging (MRI) and assess the correlation between the volume of the ischemic lesion and neurobehavioral status during the subacute stage of ischemic stroke. Ischemic stroke was induced in 6 healthy laboratory beagles through permanent occlusion of the middle cerebral artery (MCAO). T2-weighted and fluid-attenuated inversion recovery (FLAIR) imaging, diffusion-weighted imaging (DWI), measurement of the apparent diffusion coefficient (ADC) ratio, and neurobehavioral evaluation were performed 3 times serially by using a 1.5-T MR system: before and 3 and 10 d after MCAO. Ischemic lesions demonstrated T2 hyperintensity, FLAIR hyperintensity, and DWI hyperintensity. The ADC ratio was decreased initially but then was increased at 10 d after MCAO. Ischemic lesion volumes on T2-weighted and FLAIR imaging were not significantly different from those on DWI. The lesion volume and neurobehavioral score showed strong correlation. Our results suggest that conventional MRI may be a reliable diagnostic tool during the subacute stage of canine ischemic stroke.
Kang
Byeong-Teck
BT
Department of Neurology, Dongguk University International Hospital, Goyang, South Korea.
Jang
Dong-Pyo
DP
Gu
Su-Hyun
SH
Lee
Jong-Hwan
JH
Jung
Dong-In
DI
Lim
Chae-Young
CY
Kim
Ha-Jung
HJ
Kim
Young-Bo
YB
Kim
Hyung-Joong
HJ
Woo
Eung-Je
EJ
Cho
Zang-Hee
ZH
Park
Hee-Myung
HM
D000818:Animals; D002545:Brain Ischemia / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D004195:Disease Models, Animal; D004285:Dogs; D017352:Echo-Planar Imaging / Q000379:methods; D005260:Female; D007089:Image Enhancement / Q000379:methods; D020244:Infarction, Middle Cerebral Artery / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011596:Psychomotor Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D011597:Psychomotor Performance / Q000502:physiology; D020521:Stroke / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology