Design, synthesis and bioactivity of catechin/epicatechin and 2-azetidinone derived chimeric molecules.
A new class of chimeric molecules have been developed. These are based on polyphenols like catechin and epicatechin and monocyclic beta-lactams. The two units are joined via a triazole linker using the 'Click Chemistry' conditions. The compounds showed good to weak antibacterial activity against Escherichia coli as well as moderate inhibition of RNase A.
Roy
Basab
B
Department of Chemistry, Indian Institute of Technology, Kharagpur 721 302, India.
Chakraborty
Arindam
A
Ghosh
Sudip K
SK
Basak
Amit
A
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001384:Azetidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002392:Catechin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D012259:Ribonuclease, Pancreatic / Q000037:antagonists & inhibitors*
C116379:2-azetidinone; D000900:Anti-Bacterial Agents; D001384:Azetidines; D004791:Enzyme Inhibitors; D002392:Catechin; D012259:Ribonuclease, Pancreatic