title: Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.
authors.affiliation: East Carolina University, Greenville, NC, USA. mccubreyj@ecu.edu
authors.forename: James A
authors.initials: JA
authors.lastname: McCubrey
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Abrams
authors.forename: Kristin
authors.initials: K
authors.lastname: Stadelman
authors.forename: William H
authors.initials: WH
authors.lastname: Chappell
authors.forename: Michelle
authors.initials: M
authors.lastname: Lahair
authors.forename: Richard A
authors.initials: RA
authors.lastname: Ferland
authors.forename: Linda S
authors.initials: LS
authors.lastname: Steelman
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D004351:Drug Resistance / Q000502:physiology*; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism; D009362:Neoplasm Metastasis; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000378:metabolism; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents; D019869:Phosphatidylinositol 3-Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D020928:Mitogen-Activated Protein Kinases; D051059:PTEN Phosphohydrolase