Life-threatening bilateral adrenal cystic neuroblastoma in an infant.
A case of neonatal bilateral adrenal mass causing severe respiratory distress and requiring an emergency debulking surgical procedure is reported. Histopathology revealed a cystic neuroblastoma stroma poor, poorly differentiated, without MYCN amplification and 1p deletion. During postoperative follow-up, a progression to stage 4s was observed, characterized by liver involvement. According to good prognostic indexes, no further treatment was administered. Both adrenal masses and hepatic nodules showed progressive decrease in size, till complete disappearance. The authors encourage a multidisciplinary approach to develop the best patient-related strategy for cystic neuroblastoma, thus reducing complications rate.
Avanzini
Stefano
S
Department of Pediatric Surgery, Gaslini Children's Hospital, Genoa, Italy. stefano.avanzini@libero.it
Conte
Massimo
M
Granata
Claudio
C
Zamorani
Enrica M
EM
Sementa
Angela R
AR
Garaventa
Alberto
A
Buffa
Piero
P
Sorrentino
Stefania
S
D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D003560:Cysts / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009447:Neuroblastoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed