Methylnaltrexone bromide: new drug for the treatment of opioid-induced bowel dysfunction.
Constipation is a common problem associated with opiates and opioid compounds used for the treatment of pain and other medical conditions, and can influence patient quality of life. Methylnaltrexone appears effective in the therapy of opioid-induced constipation and will be useful for patients failing to respond to traditional laxative regimens.
Baker
Danial E
DE
Drug Information Center, Department of Pharmacotherapy, College of Pharmacy, Washington State University, Spokane, WA, USA.
D000701:Analgesics, Opioid / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D003248:Constipation / Q000139:chemically induced* / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005772:Gastrointestinal Transit / Q000187:drug effects; D006207:Half-Life; D006801:Humans; D007262:Infusions, Intravenous; D055104:Infusions, Subcutaneous; D054368:Laxatives / Q000627:therapeutic use; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology / Q000627:therapeutic use
D000701:Analgesics, Opioid; D054368:Laxatives; D009292:Narcotic Antagonists; D000644:Quaternary Ammonium Compounds; C032257:methylnaltrexone; D009271:Naltrexone