Towards the immune proteome of Staphylococcus aureus - The anti-S. aureus antibody response.
This review provides an overview of the antibody response against Staphylococcus aureus, which challenges the adaptive immune system with a broad and highly variable antigen repertoire. The mechanisms by which antibodies shape the interaction between S. aureus and its host are introduced, and evidence for a role of adaptive immunity in the protection against S. aureus is discussed. Techniques are now available to map the core and the variable S. aureus immune proteomes, which constitute the knowledge base for the design of effective anti-S. aureus vaccine compositions. This will require coordinated approaches that match the antigen repertoire of an infecting or colonizing S. aureus strain with the individual antibody response directed against it.
Holtfreter
Silva
S
Institut für Immunologie und Transfusionsmedizin, Ernst-Moritz-Arndt-Universität Greifswald, Sauerbruchstrasse, Neubau P, D-17475 Greifswald, Germany.
Kolata
Julia
J
Bröker
Barbara M
BM
D056704:Adaptive Immunity; D000818:Animals; D000917:Antibody Formation; D000942:Antigens, Bacterial / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D020543:Proteome / Q000276:immunology*; D013203:Staphylococcal Infections / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D013209:Staphylococcal Vaccines / Q000276:immunology / Q000627:therapeutic use; D013211:Staphylococcus aureus / Q000502:physiology*
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D020543:Proteome; D013209:Staphylococcal Vaccines