GRA proteins of Toxoplasma gondii: maintenance of host-parasite interactions across the parasitophorous vacuolar membrane.
The dense granule of Toxoplasma gondii is a secretory vesicular organelle of which the proteins participate in the modification of the parasitophorous vacuole (PV) and PV membrane for the maintenance of intracellular parasitism in almost all nucleated host cells. In this review, the archives on the research of GRA proteins are reviewed on the foci of finding GRA proteins, characterizing molecular aspects, usefulness in diagnostic antigen, and vaccine trials in addition to some functions in host-parasite interactions.
Nam
Ho-Woo
HW
Department of Parasitology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea. howoo@catholic.ac.kr
D000818:Animals; D000953:Antigens, Protozoan / Q000378:metabolism*; D003594:Cytoplasmic Granules / Q000378:metabolism; D006790:Host-Parasite Interactions; D006801:Humans; D015800:Protozoan Proteins / Q000378:metabolism*; D014122:Toxoplasma / Q000378:metabolism*; D014123:Toxoplasmosis / Q000469:parasitology*; D014617:Vacuoles / Q000378:metabolism*
D000953:Antigens, Protozoan; D015800:Protozoan Proteins