Primary open angle glaucoma and intraocular pressure in patients with systemic hypertension.
OBJECTIVE
To investigate the association between Primary Open Angle Glaucoma (POAG), Intraocular Pressure (IOP) and systemic hypertension.


METHODS
Cross-sectional, convenient and controlled study.


METHODS
Eye Clinic of the Lagos University Teaching hospital, Idi-Araba, Lagos, Nigeria.


METHODS
Consecutive newpatients with documented history of hypertension medication of over three months and current attendees at hypertension clinic of the same hospital were enrolled into the study.


RESULTS
A total of 150 hypertensive patients and 50 age-sex matched controls were studied. Age range of hypertensives was 34-54 years and controls 31-71 years. The mean age for hypertensive group was 56 years (+/- 12.95) and controls 54.76 years (+/- 9.65) p > 0.1. The mean IOP was 28.45 mmHg (+/- 10.3) in hypertensive group and 15.2 mmHg (+/- 5.09) in controls (P < 0.001). POAG was present in 58 (38.7%) of the hypertensive patients whilst only nine (18.0%) had POAG in control group (p < 0.01 odds ratio: 22). lOP > 21 mmHg was found in 28 (18.7) of hypertensive group and two (4.0%) of the control (p < 0.01 odds ratio 4.7).


CONCLUSIONS
Systemic hypertension showed a modest positive association with elevated intraocular pressure. The strong relationship with IOP in part supports the association with POAG.
Onakoya
A O
AO
Guinness Eye Centre, Lagos University Teaching Hospital/College of Medicine, University of Lagos, Idi-Araba, PMB 12003, Lagos, Nigeria.
Ajuluchukwu
J N
JN
Alimi
H L
HL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D016017:Odds Ratio; D012307:Risk Factors
D000959:Antihypertensive Agents