title: Antitumor components from Naematoloma fasciculare.
abstract: The bioassay-guided fractionation of MeOH extract from Naematoloma fasciculare afforded a petroleum ether fraction (NFPF) and four known compounds, which showed good antitumor activities to inhibit MCF-7 cell line proliferation in vitro and tumor growth in H(22) implanted mice in vivo. In addition, a number of unsaturated aliphatic acids were identified in NFPF by GC analysis. These results showed that NFPF inhibits tumor growth through the activity of unsaturated aliphatic acids together with two active compounds, ergosterol peroxide (1: 62.17 mg/g in NFPF) and ergosterol (2: 3.13 mg/g in NFPF), and indicate the potential utility of NFPF as an antitumor drug.
authors.affiliation: College of Chinese Medicinal Material, Jilin Agricultural University, Changchun, Jilin 130-118, P. R. China.
authors.forename: Ding
authors.initials: D
authors.lastname: Yan
authors.forename: Hai Ying
authors.initials: HY
authors.lastname: Bao
authors.forename: Tolgor
authors.initials: T
authors.lastname: Bau
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001685:Biological Factors / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D001685:Biological Factors