A simple analysis of a simple crossover trial with a dichotomous outcome measure.
For the two-treatment two-period crossover trial with a dichotomous outcome measure a simple and straightforward analysis is proposed: compute the treatment difference for each of the treatment sequences AB and BA, and then average over the sequence groups. The mean difference is used in the statistical test and in the computation of the 95 per cent confidence interval. The method is generalized to the case of a crossover trial including more than two treatments.
Schouten
Hubert
H
Department of Methodology and Statistics, University of Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands.
Kester
Arnold
A
D000420:Albuterol / Q000008:administration & dosage / Q000627:therapeutic use; D000465:Algorithms; D000704:Analysis of Variance; D001250:Asthma, Exercise-Induced / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D016001:Confidence Intervals; D018592:Cross-Over Studies; D015340:Epidemiologic Research Design; D004983:Ethanolamines / Q000008:administration & dosage / Q000627:therapeutic use; D000068759:Formoterol Fumarate; D006801:Humans; D015233:Models, Statistical; D011336:Probability; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D018401:Sample Size; D016896:Treatment Outcome
D001993:Bronchodilator Agents; D004983:Ethanolamines; D000420:Albuterol; D000068759:Formoterol Fumarate