Experience-dependent compartmentalized dendritic plasticity in rat hippocampal CA1 pyramidal neurons.
The excitability of individual dendritic branches is a plastic property of neurons. We found that experience in an enriched environment increased propagation of dendritic Na(+) spikes in a subset of individual dendritic branches in rat hippocampal CA1 pyramidal neurons and that this effect was mainly mediated by localized downregulation of A-type K(+) channel function. Thus, dendritic plasticity might be used to store recent experience in individual branches of the dendritic arbor.
Makara
Judit K
JK
Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA. makaraj@janelia.hhmi.org
Losonczy
Attila
A
Wen
Quan
Q
Magee
Jeffrey C
JC
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology* / Q000502:physiology*; D003712:Dendrites / Q000502:physiology*; D015536:Down-Regulation / Q000502:physiology; D004777:Environment; D008568:Memory / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D015221:Potassium Channels / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats
D015221:Potassium Channels