Pseudophosphatases: grab and hold on.
Catalytically inactive pseudophosphatases are able to signal in the absence of enzymatic activity. Analyzing the oocyte-to-zygote transition in the worm, Cheng et al. (2009) and Parry et al. (2009) now show how two pseudophosphatases, EGG-4 and EGG-5, can regulate signaling by the DYRK family kinase MBK-2.
Tonks
Nicholas K
NK
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. tonks@cshl.edu
D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology / Q000201:enzymology* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D015398:Signal Transduction
D029742:Caenorhabditis elegans Proteins; D017027:Protein Tyrosine Phosphatases