title: Single domain amnestic MCI: a multiple cognitive domains fMRI investigation.
abstract: Amnestic mild cognitive impairment (a-MCI) is associated with the highest annual incidence of conversion to Alzheimer's disease (AD) (10-15%). a-MCI patients may have only a memory deficit (single domain: sd-a-MCI) or additional dysfunctions affecting other cognitive domains (multiple domain: md-a-MCI). Using functional magnetic resonance imaging (fMRI), we investigated brain activation in 16 sd-a-MCI patients and 14 controls during four different tasks assessing language, memory, attention and empathy functions. We found greater activation in sd-a-MCI compared with controls in the left inferior temporal gyrus (language), the right superior temporal gyrus (memory) and the right dorsal precentral gyrus (attention). Moreover, patients' activation correlated significantly with neuropsychological scores obtained at tests exploring the corresponding function. These findings indicate that fMRI is sensitive to detect early changes occurring in AD pathology and that individuals with sd-a-MCI show increased activation in multiple task-related brain regions. We suggest that these functional changes relate to the development of early compensatory mechanisms that reduce cognitive deficits associated with the progressive accumulation of brain damage.
authors.affiliation: Department of Neurological Sciences, Università Sapienza, Viale dell'Università 30, 00185 Rome, Italy. delia.lenzi@gmail.com
authors.forename: D
authors.initials: D
authors.lastname: Lenzi
authors.forename: L
authors.initials: L
authors.lastname: Serra
authors.forename: R
authors.initials: R
authors.lastname: Perri
authors.forename: P
authors.initials: P
authors.lastname: Pantano
authors.forename: G L
authors.initials: GL
authors.lastname: Lenzi
authors.forename: E
authors.initials: E
authors.lastname: Paulesu
authors.forename: C
authors.initials: C
authors.lastname: Caltagirone
authors.forename: M
authors.initials: M
authors.lastname: Bozzali
authors.forename: E
authors.initials: E
authors.lastname: Macaluso
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000647:Amnesia / Q000175:diagnosis* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000503:physiopathology; D008875:Middle Aged; D012720:Severity of Illness Index