title: 2,4-Diaryl-4,6,7,8-tetrahydroquinazolin-5(1H)-one derivatives as anti-HBV agents targeting at capsid assembly.
abstract: A series of novel 2,4-diaryl-4,6,7,8-tetrahydroquinazolin-5(1H)-one derivatives were designed and synthesized as potent inhibitors of HBV capsid assembly. These compounds arose from efforts to rigidify an earlier series of heteroaryldihydropyrimidines (HAPs), and compounds 12, 13, 20, 24, 30 and 32 showed potent inhibition of HBV capsid assembly, especially 24 with IC(50) value at sub-micromolar range.
authors.affiliation: School of Pharmacy, Jilin University, Changchun 130021, PR China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhu
authors.forename: Guoming
authors.initials: G
authors.lastname: Zhao
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zhou
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Xu
authors.forename: Guangqiang
authors.initials: G
authors.lastname: Xia
authors.forename: Zhibing
authors.initials: Z
authors.lastname: Zheng
authors.forename: Lili
authors.initials: L
authors.lastname: Wang
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Yang
authors.forename: Song
authors.initials: S
authors.lastname: Li
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002213:Capsid / Q000187:drug effects / Q000378:metabolism*; D052999:Quinazolinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D052999:Quinazolinones