Identification of candidate genes determining chemosensitivity to anti-cancer drugs of gastric cancer cell lines.
In order to efficiently develop improved cancer therapies it is important to predict the efficacy of anti-cancer drugs. In this regard, identification of genes that are related to drug sensitivity is vital. We previously established a panel of 39 human cancer cell lines (JFCR39) and a panel aiming for organ-specific analysis of 45 human cancer cell lines (JFCR45). Here, we focus on 20 human gastric cancer cell lines from JFCR45, a panel of human cancer cell lines to predict genes that determine chemosensitivity to anti-cancer drugs. We measured both chemosensitivity to a range of anti-cancer drugs as well as changes in gene expression profile. We then identified genes in which expression is related to chemosensitivity by using a Pearson correlation. As a result, anti-cancer drugs that have similar mechanisms of action showed similar fingerprints against a gastric subpanel of human cancer cell lines, as was the case with JFCR39 and JFCR45. Furthermore, we identified many candidate genes related to the sensitivity of gastric cancer cells to anti-cancer drugs.
Nakamura
Tomoki
T
Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Ariake, Koto-ku, Tokyo 135-8550, Japan.
Nakatsu
Noriyuki
N
Yoshida
Yoko
Y
Yamazaki
Kanami
K
Dan
Shingo
S
Sadahiro
Soutaro
S
Makuuchi
Hiroyasu
H
Yamori
Takao
T
D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
D000970:Antineoplastic Agents