Guidance receptors find their places in the axonal order.
In this issue of Neuron, Katsuki and colleagues show that cell-autonomous mechanisms divide Drosophila axons into proximal and distal compartments. Axon guidance receptors selectively localize to one compartment. A diffusion barrier exists near the compartment boundary, suggesting that it may have properties like those of the axon initial segment in mammalian neurons.
Wright
Ashley P
AP
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. ashley@caltech.edu
Zinn
Kai
K
D000818:Animals; D001369:Axons / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology*; D004330:Drosophila; D009474:Neurons / Q000166:cytology