Bioactive jatrophane diterpenes from Euphorbia guyoniana.
Chromatographic investigation of the methylenechloride/methanol extract of the aerial parts of Euphorbia guyoniana afforded two jatrophane diterpenes, designated guyonianins E and F, in addition to a known jatrophane diterpene. The structures of the compounds were determined by comprehensive NMR analyses, including DEPT, COSY, HMQC, HMBC, NOESY and HRMS. These compounds exhibited cytotoxicity against human embryonic kidney 293 (HEK293) cells with IC(50) values of 35-100 microM.
Hegazy
Mohamed-Elamir F
ME
Chemistry of Medicinal Plants Department, National Research Center, Dokki, Cairo, Egypt.
Mohamed
Abou El-Hamd H
Ael-H
Aoki
Nobuwa
N
Ikeuchi
Toshitaka
T
Ohta
Emi
E
Ohta
Shinji
S
D002460:Cell Line; D003603:Cytotoxins / Q000737:chemistry / Q000494:pharmacology*; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
D003603:Cytotoxins; D004224:Diterpenes; D010936:Plant Extracts; C551326:guyonianin E; C551327:guyonianin F