Novel system for decarboxylative bromination of alpha,beta-unsaturated carboxylic acids with diacetoxyiodobenzene.
A simple and mild method for the conversion of varieties of alpha,beta-unsaturated carboxylic acids to the corresponding bromoalkenes using diacetoxyiodobenzene (IBD) in combination with tetraethyl-ammonium bromide (TEAB) at room temperature is discussed. Advantages of this system are short reaction time, easy work up and gave good to excellent yields.
Fursule
Ravindra Abhykumar
RA
Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur 425405, Maharashtra, India.
Patil
Pravin Onkar
PO
Shewale
Bharti Devaji
BD
Kosalge
Satish Bhaskar
SB
Deshmukh
Prashant Krishnarao
PK
Patil
Dilip Ashok
DA
D002264:Carboxylic Acids / Q000737:chemistry*; D003653:Decarboxylation; D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis* / Q000737:chemistry; D007462:Iodobenzenes / Q000737:chemistry*; D015394:Molecular Structure; D019789:Tetraethylammonium / Q000737:chemistry
D002264:Carboxylic Acids; D006842:Hydrocarbons, Brominated; D007462:Iodobenzenes; D019789:Tetraethylammonium