title: New small molecule inhibitors of hepatitis C virus.
abstract: New small molecule inhibitors of HCV were discovered by screening a small library of indoline alkaloid-type compounds. An automated assay format was employed which allowed identification of dimerization inhibitors of core, the capsid protein of the virus. These compounds were subsequently shown to block production of infectious virus in hepatoma cells.
authors.affiliation: Department of Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA 02215, USA.
authors.forename: Wanguo
authors.initials: W
authors.lastname: Wei
authors.forename: Cuifang
authors.initials: C
authors.lastname: Cai
authors.forename: Smitha
authors.initials: S
authors.lastname: Kota
authors.forename: Virginia
authors.initials: V
authors.lastname: Takahashi
authors.forename: Feng
authors.initials: F
authors.lastname: Ni
authors.forename: A Donny
authors.initials: AD
authors.lastname: Strosberg
authors.forename: John K
authors.initials: JK
authors.lastname: Snyder
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D016174:Hepacivirus / Q000187:drug effects*; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D026121:Indole Alkaloids