Bisphosphonate-related osteonecrosis of the jaw: the role of actinomyces.
The etiology of bisphosphonate-related osteonecrosis of the jaw is unknown but was initially postulated to be mediated by bisphosphonate accumulation within the jaws, resulting in avascular necrosis. Bisphosphonates may not be the primary cause. Actinomyces are an underrecognized agent in pathogenesis, and timely actinomycosis-specific treatment may improve outcome.
Naik
Nimesh H
NH
Department of Medicine, Veterans Administration Western New York Healthcare System, University at Buffalo/State University of New York, Buffalo, NY, USA.
Russo
Thomas A
TA
D000190:Actinomyces / Q000502:physiology*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced / Q000209:etiology* / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced / Q000209:etiology* / Q000382:microbiology*
D050071:Bone Density Conservation Agents; D004164:Diphosphonates