Dopamine and synaptic plasticity in dorsal striatal circuits controlling action selection.
The striatum is thought to play a central role in learning how to choose acts that lead to reward and avoid punishment. Dopamine-dependent modification of striatal synapses in the action selection circuitry has long been thought to be a key step toward this type of learning. The development of new genetic and optical tools has pushed this field forward in the last couple of years, demanding a re-evaluation of models of how experience controls dopamine-dependent synaptic plasticity and how disease states like Parkinson's disease affect the striatal circuitry.
Surmeier
D James
DJ
Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Plotkin
Joshua
J
Shen
Weixing
W
D000818:Animals; D003342:Corpus Striatum / Q000166:cytology*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D009068:Movement / Q000502:physiology*; D009415:Nerve Net / Q000166:cytology*; D009473:Neuronal Plasticity / Q000502:physiology*; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D013569:Synapses / Q000502:physiology*
D004298:Dopamine