title: [Neuromyelitis optica spectrum: novel concept of pathogenesis, diagnosis and treatment of Devic's disease].
abstract: The identification of autoantibodies generated against the brain isoform water channel aquaporin4 in the sera of patients, changed the current diagnostic guidelines and concept of neuromyelitis optica (NMO). In a number of cases, clinical manifestation is spatially limited to myelitis or relapsing optic neuritis creating a diverse. NMO spectrum. Since prevention of relapses provides the only possibility to reduce permanent disability, early diagnosis and treatment is mandatory. In the present study, we discuss the potential role of neuroimaging and laboratory tests in differentiating the NMO spectrum from other diseases, as well as the diagnostic procedures and therapeutic options. We also present clinical cases, to provide examples of different clinical settings, diagnostic procedures and therapeutic decisions.
authors.affiliation: Pécsi Tudományegyetem, Altalános Orvostudományi Kar, Klinikai Központ Neurológiai Klinika Pécs Rét u. 2. 7623.
authors.forename: Péter
authors.initials: P
authors.lastname: Csécsei
authors.forename: Anita
authors.initials: A
authors.lastname: Trauninger
authors.forename: Sámuel
authors.initials: S
authors.lastname: Komoly
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Illés
mesh_terms: D000328:Adult; D017668:Age of Onset; D051401:Aquaporin 4 / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D009443:Neuritis / Q000209:etiology; D009471:Neuromyelitis Optica / Q000150:complications / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D009900:Optic Nerve / Q000473:pathology*; D011379:Prognosis; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D015415:Biomarkers; D007074:Immunoglobulin G