title: Pyoverdine and PQS mediated subpopulation interactions involved in Pseudomonas aeruginosa biofilm formation.
abstract: Summary Using flow chamber-grown Pseudomonas aeruginosa biofilms as model system, we show in the present study that formation of heterogeneous biofilms may occur through mechanisms that involve complex subpopulation interactions. One example of this phenomenon is expression of the iron-siderophore pyoverdine in one subpopulation being necessary for development of another subpopulation that does not itself express the pyoverdine synthesis genes. Another example is quorum sensing-controlled DNA release in one subpopulation being necessary for development of another subpopulation that does not itself express the quorum-sensing genes.
authors.affiliation: Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.
authors.forename: Liang
authors.initials: L
authors.lastname: Yang
authors.forename: Martin
authors.initials: M
authors.lastname: Nilsson
authors.forename: Morten
authors.initials: M
authors.lastname: Gjermansen
authors.forename: Michael
authors.initials: M
authors.lastname: Givskov
authors.forename: Tim
authors.initials: T
authors.lastname: Tolker-Nielsen
mesh_terms: D018441:Biofilms / Q000254:growth & development*; D004269:DNA, Bacterial / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D009842:Oligopeptides / Q000378:metabolism*; D011550:Pseudomonas aeruginosa / Q000502:physiology*; D015363:Quinolones / Q000378:metabolism*; D013559:Symbiosis
chemical_list: C407944:2-heptyl-3-hydroxy-4-quinolone; D004269:DNA, Bacterial; D009842:Oligopeptides; D015363:Quinolones; C042453:pyoverdin; D007501:Iron