title: Asbestos fibre dimensions and lung cancer mortality among workers exposed to chrysotile.
abstract: OBJECTIVE
  To estimate exposures to asbestos fibres of specific sizes among asbestos textile manufacturing workers exposed to chrysotile using data from transmission electron microscopy (TEM) and to evaluate the extent to which the risk of lung cancer varies with fibre length and diameter.
  
  
  METHODS
  3803 workers employed for at least 1 day between 1 January 1950 and 31 December 1973 in any of three plants in North Carolina, USA that produced asbestos textile products and followed for vital status through 31 December 2003 were included. Historical exposures to asbestos fibres were estimated from work histories and 3578 industrial hygiene measurements taken in 1935-1986. Exposure-response relationships for lung cancer were examined within the cohort using Poisson regression.
  
  
  RESULTS
  Indicators of fibre length and diameter obtained by TEM were positively and significantly associated with increasing risk of lung cancer. Exposures to longer and thinner fibres tended to be most strongly associated with lung cancer, and models for these fibres fit the data best. Simultaneously modelling indicators of cumulative mean fibre length and diameter yielded a positive coefficient for fibre length and a negative coefficient for fibre diameter.
  
  
  CONCLUSIONS
  The results support the hypothesis that the risk of lung cancer among workers exposed to chrysotile asbestos increases with exposure to longer fibres. More research is needed to improve the characterisation of exposures by fibre size and number and to analyse the associated risks in a variety of industries and populations.
authors.affiliation: School of Community Health Sciences/MS-274, University of Nevada, Reno, NV 89557, USA. dploomis@unr.edu
authors.forename: Dana
authors.initials: D
authors.lastname: Loomis
authors.forename: John
authors.initials: J
authors.lastname: Dement
authors.forename: David
authors.initials: D
authors.lastname: Richardson
authors.forename: Susanne
authors.initials: S
authors.lastname: Wolf
mesh_terms: D017632:Asbestos, Serpentine / Q000737:chemistry / Q000633:toxicity*; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000401:mortality; D008297:Male; D008854:Microscopy, Electron; D009657:North Carolina / Q000453:epidemiology; D009784:Occupational Diseases / Q000209:etiology* / Q000401:mortality; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis; D010316:Particle Size; D013783:Textile Industry
chemical_list: D017632:Asbestos, Serpentine