title: [Search of prostatic tissue in 46,XX congenital adrenal hyperplasia].
abstract: OBJECTIVE
  To describe the presence of prostatic tissue in 46,XX patients with the classical form of congenital adrenal hyperplasia (CAH); to evaluate the sensitivity and specificity of prostatic specific antigen (PSA) measured in congenital adrenal hyperplasia patients with regard to the detection of prostatic tissue in pelvic MRI.
  
  
  METHODS
  We studied 52 children and adolescents, 32 with the classical form of congenital adrenal hyperplasia, 10 boys and 10 girls without CAH. Pelvic MRI was performed in all patients to detect prostatic tissue. Prostate specific antigen, testosterone and dihydrotestosterone were measured in all patients. We used Receiver Operating Characteristic Curve for PSA discrimination capacity.
  
  
  RESULTS
  Five girls with congenital adrenal hyperplasia showed image of prostatic tissue on pelvic MRI. Prostate specific antigen showed sensitivity and specificity of 100% and 88.9%, respectively, taking 0.1 ng/mL as the cutoff level.
  
  
  CONCLUSIONS
  The incidence of prostatic tissue in 46,XX patients with the classical form of congenital adrenal hyperplasia was 15.6%. PSA demonstrated to be a good marker of prostatic tissue in these patients and should be used to screen patients to be submitted to image studies.
authors.affiliation: Departamento de Endocrinologia Pediátrica, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil. marianacrp@hotmail.com
authors.forename: Mariana da Costa Rose
authors.initials: Mda C
authors.lastname: Paulino
authors.forename: Leandra
authors.initials: L
authors.lastname: Steinmetz
authors.forename: Hamilton Cabral de
authors.initials: HC
authors.lastname: Menezes Filho
authors.forename: Hilton
authors.initials: H
authors.lastname: Kuperman
authors.forename: Thaís
authors.initials: T
authors.lastname: Della Manna
authors.forename: José Gilberto Henriques
authors.initials: JG
authors.lastname: Vieira
authors.forename: Roberto
authors.initials: R
authors.lastname: Blasbalg
authors.forename: Ronaldo
authors.initials: R
authors.lastname: Baroni
authors.forename: Nuvarte
authors.initials: N
authors.lastname: Setian
authors.forename: Durval
authors.initials: D
authors.lastname: Damiani
mesh_terms: D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000097:blood / Q000235:genetics / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D013196:Dihydrotestosterone / Q000097:blood*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008279:Magnetic Resonance Imaging; D008297:Male; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D019849:Sex Determination Processes; D013739:Testosterone / Q000097:blood*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D013196:Dihydrotestosterone; D013739:Testosterone; D017430:Prostate-Specific Antigen