An association analysis between mitochondrial DNA A10398G polymorphism and temperament in Japanese young adults.
The mitochondrial (mt) DNA C5178A and A10398G polymorphisms have been reported to be associated with mental disorders such as bipolar disorder. However, the effects of these polymorphisms on temperament in healthy people are poorly understood. Evaluating healthy subjects can have the advantage of providing new strategies for maintaining psychological health and preventing mental illness. We examined the association between mtDNA polymorphisms and temperament in Japanese students. There was no significant difference in examined temperament when analysed by genotypes, 5178-10398 haplotypes, or sex. The subgroup analysis based on sex indicated that there was an interactive effect of the mtDNA A10398G polymorphism and sex on anxiety and obsession. This finding is preliminary and cannot exclude the possibility of false-positive due to small sample size (144 subjects) and multiple statistical testing. Further studies involving a larger sample size or other ethnic groups are necessary to confirm that mtDNA A10398G polymorphism can be a genetic factor for temperament.
Kishida
Kunihiro
K
Graduate School of Human Health Sciences, University of Nagasaki, Siebold, Nagayo, Nagasaki, Japan. kunihiro@sun.ac.jp
Tominaga
Mihoko
M
Matsubara
Kiminori
K
Taguchi
Masanori
M
Noguchi
Masanori
M
Tsunawake
Noriaki
N
Shidoji
Yoshihiro
Y
D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D005189:False Positive Reactions; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007564:Japan; D008297:Male; D015233:Models, Statistical; D011110:Polymorphism, Genetic; D055815:Young Adult
D004272:DNA, Mitochondrial