New 14-membered octaazamacrocyclic complexes of divalent transition metal ions with their antimicrobial and spectral studies.
A novel series of macrocyclic complexes of the type [M(C(18)H(14)N(10)S(2))X(2)]; where M=Co(II), Ni(II), Cu(II), Zn(II) and Cd(II); X=Cl(-), NO(3)(-), CH(3)COO(-) has been synthesized by [2+2] condensation of thiocarbohydrazide and isatin in the presence of divalent metal salts in methanolic medium. The complexes have been characterized with the help of elemental analyses, conductance measurements, magnetic measurements, electronic, NMR and infrared spectral studies. The low value of molar conductance indicates them to be non-electrolytes. On the basis of various studies a distorted octahedral geometry may be proposed for all of these complexes. These metal complexes were also tested for their in vitro antimicrobial activities against some Gram-positive bacteria viz. Staphylococcus aureus, Bacillus subtilis, and some Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosa and some fungal strains Aspergillus niger, Aspergillus flavus (molds), Candida albicans, Saccharomyces cerevisiae (yeasts). The results obtained were compared with standard antibiotic: Ciprofloxacin and the standard antifungal drug: Amphotericin-B.
Singh
D P
DP
Department of Chemistry, National Institute of Technology, Kurukshetra, India. dpsinghchem@yahoo.co.in
Kumar
Krishan
K
Sharma
Chetan
C
D000666:Amphotericin B / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002939:Ciprofloxacin / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D005658:Fungi / Q000187:drug effects; D047028:Macrocyclic Compounds / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D028561:Transition Elements / Q000737:chemistry*
D000890:Anti-Infective Agents; D047028:Macrocyclic Compounds; D008670:Metals; D028561:Transition Elements; D002939:Ciprofloxacin; D000666:Amphotericin B