title: Clinical outcome of Taiwanese men with clinically localized prostate cancer post-radical prostatectomy: a comparison with other ethnic groups.
abstract: BACKGROUND
  Prostate cancer incidence varies significantly among different ethnic groups. However, the report concerning the clinical outcome after radical prostatectomy (RP) in the low incidence Asian population is still limited. We aimed to compare the clinical outcome in patient treated with RP among different ethnic groups and to identify significant prognostic factors in Taiwanese patients.
  
  
  METHODS
  A total of 341 patients with clinical localized prostate cancer undergoing curative RP in three medical centers in Taiwan were included in this study. Ethnic group comparison was performed using the CaPSURE, SEARCH databases from United States (US) and one large European series. The Kaplan-Meier analysis and Cox proportional hazard model were used to identify significant predictors for prostate-specific antigen (PSA) recurrence.
  
  
  RESULTS
  Compared to the Caucasian white population in the US and Europe studies, the Taiwanese population have higher age at surgery and higher pre-operative PSA level. With mean and median follow-up of 39.1 months and 31.0 months (range 5-120 months), 127 men (37.2%) had PSA recurrence which was significant higher than the Western series. Significant predictors for PSA recurrence identified in the post-operative overall model were PSA level, pathological Gleason Score, pathological tumor stage and lymph node metastasis.
  
  
  CONCLUSIONS
  The clinical outcome of Taiwanese male with prostate cancer post-RP appears inferior to the Western country, which is largely due to delay surgery at higher PSA level. Earlier diagnosis and treatment may improve the cancer control of RP.
authors.affiliation: Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Shu-pin
authors.initials: SP
authors.lastname: Huang
authors.forename: Chao-Yuan
authors.initials: CY
authors.lastname: Huang
authors.forename: Chia-Chu
authors.initials: CC
authors.lastname: Liu
authors.forename: Chia-Cheng
authors.initials: CC
authors.lastname: Yu
authors.forename: Yeong-Shiau
authors.initials: YS
authors.lastname: Pu
authors.forename: Shih-Chieh
authors.initials: SC
authors.lastname: Chueh
authors.forename: Hong-Jeng
authors.initials: HJ
authors.lastname: Yu
authors.forename: Tony T
authors.initials: TT
authors.lastname: Wu
authors.forename: Ching-Chia
authors.initials: CC
authors.lastname: Li
authors.forename: Chun-Hsiung
authors.initials: CH
authors.lastname: Huang
authors.forename: Wen-Jeng
authors.initials: WJ
authors.lastname: Wu
mesh_terms: D000368:Aged; D044466:Asian People; D018572:Disease-Free Survival; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000401:mortality / Q000601:surgery*; D013624:Taiwan; D044465:White People
chemical_list: D017430:Prostate-Specific Antigen