title: Wide-spectrum profile of inflammatory mediators in the plasma and scales of patients with psoriatic disease.
abstract: Psoriasis is a chronic recurrent inflammatory disorder of the skin. Clinical subtypes include psoriasis vulgaris (PV), psoriatic arthropathy, and erythrodermic psoriasis. Aim of this study was to analyse relevant inflammatory mediators in the plasma of patients with distinct subtypes of active psoriasis, and in the scales of mild-to-moderate PV patients, and correlation to disease severity. Compared to healthy controls (n=10), patients affected by very severe forms of psoriasis (n=30) were characterized by increased plasma levels of IL-4, IL-6, MCP-1, VEGF and in particular PDGFbb. Each group with severe psoriasis had distinct characteristic features of plasma cytokine profile. Mild-to-moderate PV patients (n=35) showed higher levels of IL-4, IL-6, IL-10, and IL-13 when compared to healthy controls. No correlation was found between PV severity assessed by PASI (Psoriasis Area and Severity Index) and levels of these mediators. By contrast, disease severity correlated to scale levels of IP-10. For the first time, we found exaggerated circulating levels of the pro-angiogenic PDGFbb and VEGF in severe psoriasis. Evidence that the severity of skin symptoms correlated exclusively with scale levels of IP-10, but not with any up-regulated inflammatory mediator in plasma, suggests that distinct skin-independent processes contribute to the circulating cytokine profile in psoriasis.
authors.affiliation: Laboratory of Tissue Engineering and Cutaneous Physiopathology, IDI-IRCCS, Via Monti di Creta 104, 00167 Rome, Italy.
authors.forename: Irina
authors.initials: I
authors.lastname: Deeva
authors.forename: Serena
authors.initials: S
authors.lastname: Mariani
authors.forename: Chiara
authors.initials: C
authors.lastname: De Luca
authors.forename: Valeria
authors.initials: V
authors.lastname: Pacifico
authors.forename: Luca
authors.initials: L
authors.lastname: Leoni
authors.forename: Desanka
authors.initials: D
authors.lastname: Raskovic
authors.forename: Zaira
authors.initials: Z
authors.lastname: Kharaeva
authors.forename: Liudmila
authors.initials: L
authors.lastname: Korkina
authors.forename: Saveria
authors.initials: S
authors.lastname: Pastore
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000276:immunology / Q000473:pathology
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators