title: Antitumor activity of diethynylfluorene derivatives of gold(I).
abstract: A list of diethynylfluorenes and their gold(I) derivatives have been studied for their antitumor activity as a function of their structure-activity relationships. End-capping the fluoren-9-one unit with gold(I) moieties could significantly strengthen the cytotoxic activity in vitro on three human cancer cell lines with induction of reactive oxygen species generation on Hep3B hepatocellular carcinoma cells and exhibit attractive antitumor activity from in vivo nude mice Hep3B xenograft model with limited adverse effects on vital organs including liver and kidney.
authors.affiliation: Institute of Textiles and Clothing, Hong Kong Polytechnic University, Hung Hom, Hong Kong, People's Republic of China.
authors.forename: Chung-Hin
authors.initials: CH
authors.lastname: Chui
authors.forename: Raymond Siu-Ming
authors.initials: RS
authors.lastname: Wong
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambari
authors.forename: Gregory Yin-Ming
authors.initials: GY
authors.lastname: Cheng
authors.forename: Marcus Chun-Wah
authors.initials: MC
authors.lastname: Yuen
authors.forename: Kit-Wah
authors.initials: KW
authors.lastname: Chan
authors.forename: See-Wai
authors.initials: SW
authors.lastname: Tong
authors.forename: Fung-Yi
authors.initials: FY
authors.lastname: Lau
authors.forename: Paul Bo-San
authors.initials: PB
authors.lastname: Lai
authors.forename: Kim-Hung
authors.initials: KH
authors.lastname: Lam
authors.forename: Cheuk-Lam
authors.initials: CL
authors.lastname: Ho
authors.forename: Chi-Wai
authors.initials: CW
authors.lastname: Kan
authors.forename: Kelvin Sze-Yin
authors.initials: KS
authors.lastname: Leung
authors.forename: Wai-Yeung
authors.initials: WY
authors.lastname: Wong
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006046:Gold / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D005449:Fluorenes; D009942:Organometallic Compounds; D006046:Gold