title: The incretins and beta-cell health: contrasting glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 as a path to understand islet function in diabetes.
authors.forename: Lene
authors.initials: L
authors.lastname: Jessen
authors.forename: David
authors.initials: D
authors.lastname: D'Alessio
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D049109:Cell Proliferation; D002470:Cell Survival; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000494:pharmacology; D000077270:Exenatide; D005749:Gastric Inhibitory Polypeptide / Q000031:analogs & derivatives / Q000494:pharmacology; D000067757:Glucagon-Like Peptide-1 Receptor; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D054795:Incretins / Q000494:pharmacology; D007328:Insulin / Q000097:blood / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D010455:Peptides / Q000494:pharmacology; D011719:Pyrazines / Q000494:pharmacology; D011964:Receptors, Gastrointestinal Hormone / Q000819:agonists / Q000378:metabolism*; D018027:Receptors, Glucagon / Q000819:agonists / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D000068900:Sitagliptin Phosphate; D014230:Triazoles / Q000494:pharmacology; D014688:Venoms / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D018819:Dipeptidyl Peptidase 4; D054873:Dipeptidyl-Peptidase IV Inhibitors; D000077270:Exenatide; D005749:Gastric Inhibitory Polypeptide; D000067757:Glucagon-Like Peptide-1 Receptor; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D054795:Incretins; D007328:Insulin; D010455:Peptides; D011719:Pyrazines; D011964:Receptors, Gastrointestinal Hormone; D018027:Receptors, Glucagon; D000068900:Sitagliptin Phosphate; D014230:Triazoles; D014688:Venoms; C000593833:GLP1R protein, human; C000593834:Glp1r protein, mouse; C041086:gastric inhibitory polypeptide receptor; C545245:Dpp4 protein, mouse