Renal hilus paraganglioma: a case report and brief review.
Paraganglioma is a rare tumour that originates from any paraganglia. Among extra-adrenal paraganglioma, renal hilus is a rare location. The authors report a case of a 43-year-old female who was admitted for evaluation of a renal mass detected incidentally by ultrasound imaging. Suspecting malignancy, the patient underwent radical nephrectomy. Upon macroscopic examination, the lesion was located into the renal hilus. Histological study revealed a neoplasm constituted of nests of monomorphic cuboidal cells with basophilic granular cytoplasm and round to oval nuclei. Necrosis was absent. The proliferative index (Mib-1) was very low (< 5%). Immunohistochemical examination revealed reactivity for neuron specific enolase (NSE), chromogranin A and synaptophysin. The final diagnosis was renal hilus paraganglioma. The paper shows the difficulty in diagnostic approaches to paraganglioma in this atypical site.
Pagni
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University Milan Bicocca, Desio Hospital, Italy. petala.83@tiscali.it
Galbiati
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Bono
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Di Bella
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D000328:Adult; D002292:Carcinoma, Renal Cell / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009392:Nephrectomy; D010236:Paraganglioma, Extra-Adrenal / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D010386:Pelvic Neoplasms / Q000473:pathology