Chasing after antibiotic leads.
The emergence of drug-resistant pathogens has prompted the search for new antibacterials. In this issue of Chemistry & Biology, Starosta et al. identify specific thiopeptide-antibiotic precursor lead compounds using three complementary high-throughput translation machinery assays.
Geiermann
Anna-Skrollan
AS
Institute of Organic Chemistry, Center for Molecular Biosciences (CMBI), University of Innsbruck, 6020 Innsbruck, Austria.
Micura
Ronald
R
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D010458:Peptidyl Transferases / Q000037:antagonists & inhibitors / Q000378:metabolism; D012270:Ribosomes / Q000737:chemistry / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013883:Thiostrepton / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D013438:Sulfhydryl Compounds; D010458:Peptidyl Transferases; D013883:Thiostrepton