Behavioral outcome measures for the assessment of sensorimotor function in animal models of movement disorders.
Animal models have and continue to contribute to our understanding of the neurobiology many types of disorders. In movement disorders such as Parkinson's disease (PD), animal models have directly led to various therapeutic treatments such as deep brain stimulation. To facilitate the development of potential therapeutics, sensitive and reliable outcome measures in animal models are necessary to maximize their benefit. In this chapter, behavioral outcome measures, sensitive to varying degrees of sensorimotor dysfunction, are reviewed in rats and mice.
Fleming
Sheila M
SM
Department of Psychology and Neurology, University of Cincinnati, Cincinnati, Ohio 45221, USA.
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology; D006892:Hydroxydopamines; D051379:Mice; D009043:Motor Activity / Q000502:physiology; D009069:Movement Disorders / Q000503:physiopathology* / Q000523:psychology*; D009425:Nesting Behavior / Q000502:physiology; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000523:psychology; D011597:Psychomotor Performance / Q000502:physiology*; D051381:Rats
D006892:Hydroxydopamines