title: Generating specificity and diversity in the transcriptional response to hypoxia.
abstract: The sensing of oxygen levels and maintenance of oxygen homeostasis is crucial for cells. The hypoxic-sensitive regulation of gene expression allows information about the oxygen status to be converted into appropriate cellular responses. Although there is a core transcriptional pathway, the signalling cascade can be modified to allow diversity and specificity in the transcriptional output. In this Review, we discuss recent advances in our understanding of the mechanisms and factors that contribute to the observed diversity and specificity. A deeper knowledge about how hypoxic signalling is tuned will further our understanding of the cellular hypoxic response in normal physiology and how it becomes derailed in disease.
authors.affiliation: Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
authors.forename: Urban
authors.initials: U
authors.lastname: Lendahl
authors.forename: Kian Leong
authors.initials: KL
authors.lastname: Lee
authors.forename: Henry
authors.initials: H
authors.lastname: Yang
authors.forename: Lorenz
authors.initials: L
authors.lastname: Poellinger
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D005786:Gene Expression Regulation; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D051793:Hypoxia-Inducible Factor 1; D010100:Oxygen