Obstructive sleep apnea is frequent in patients with hypertensive intracerebral hemorrhage and is related to perihematoma edema.
BACKGROUND
Obstructive sleep apnea (OSA) is related to increased systemic inflammation and arterial hypertension. We hypothesize that OSA is frequent in patients with acute hypertensive intracerebral hemorrhage (ICH) and is related to the perihematoma edema.


METHODS
Thirty-two non-comatose patients with a hypertensive ICH underwent polysomnography in the acute phase. Perihematoma edema volume was measured on CT scans at admission, after 24 h (early control) and after 4-5 days (late control). The Spearman coefficient (r(s)) was used for correlations.


RESULTS
OSA occurred in 19 (59.4%) patients. The apnea-hypopnea index was correlated with relative edema at admission CT (r(s) = 0.40; p = 0.031), early CT (r(s) = 0.46; p = 0.011) and at late CT (r(s) = 0.59; p = 0.006).


CONCLUSIONS
OSA is highly frequent during the acute phase of hypertensive ICH and is related to perihematoma edema.
Pontes-Neto
Octavio M
OM
Department of Neuroscience and Behavior, Ribeirão Preto School of Medicine, University of São Paulo, São Paulo, Brazil. octaviopontes@rnp.fmrp.usp.br
Fernandes
Regina M F
RM
Sander
Heidi H
HH
da Silva
Larissa A T
LA
Mariano
Débora C
DC
Nobre
Fernando
F
Simão
Gustavo
G
de Araujo
Draulio B
DB
dos Santos
Antonio C
AC
Leite
João P
JP
D000208:Acute Disease; D000368:Aged; D001929:Brain Edema / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D006406:Hematoma / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D020299:Intracranial Hemorrhage, Hypertensive / Q000150:complications* / Q000000981:diagnostic imaging; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D017286:Polysomnography; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000209:etiology*; D013997:Time Factors; D014057:Tomography, X-Ray Computed