Granatumins A-G, limonoids from the seeds of a Krishna mangrove, Xylocarpus granatum.
Seven new limonoids (1-7), named granatumins A-G, were isolated from seeds of an Indian mangrove (Xylocarpus granatum) collected from the wetlands of Krishna estuary, Andhra Pradesh. The known compounds khayasin T, tigloylseneganolide A, 6-deoxyswietenine, swietemahonolide, febrifugin A, gedunin, xylogranatinin, phaseic acid, (2R,3R)-3,4',5,7-tetrahydroxyflavanone, and (E)-4-hydroxycinnamic acid were also isolated. The structures were established on the basis of spectroscopic data. Granatumins A and B are mexicanolides with endo-conjugated Delta(8,30) and Delta(14,15) double bonds, and granatumins F and G are polyhydroxylated phragmalins found previously in plants of the Meliaceae. Khayasin T exhibited moderate insecticidal activity against fifth instar larvae of Brontispa longissima (Gestro) at a concentration of 20 mg/L.
Li
Min-Yi
MY
Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
Yang
Xiao-Bo
XB
Pan
Jian-Yu
JY
Feng
Gang
G
Xiao
Qiang
Q
Sinkkonen
Jari
J
Satyanandamurty
Tirumani
T
Wu
Jun
J
D000818:Animals; D003059:Cocos / Q000469:parasitology; D001517:Coleoptera / Q000187:drug effects; D006801:Humans; D007194:India; D007814:Larva / Q000187:drug effects; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010935:Plant Diseases / Q000469:parasitology; D012639:Seeds / Q000737:chemistry; D013237:Stereoisomerism
D036701:Limonins