Association of G1057D variant of insulin receptor substrate-2 with endometriosis.
OBJECTIVE
To investigate whether the insulin receptor substrate (IRS)-2 G1057D polymorphism is associated with the risk of endometriosis, and to evaluate potential correlation of IRS2 gene polymorphism with the stages of endometriosis.


METHODS
Case-control study.


METHODS
Gynecology clinics in university hospital.


METHODS
Women with (n = 135) or without (n = 135) endometriosis. Afterward, the women with endometriosis were divided into two groups according to the stage: group 1 included 63 women in stages I-II, and group 2 included 72 women in stages III-IV.


METHODS
Genotyping by polymerase chain reaction-based restriction fragment-length polymorphism method.


METHODS
Genotype distribution of the G1057D polymorphism in the IRS2 gene.


RESULTS
The genotype distribution of the IRS2 G1057D polymorphism in the endometriosis group was significantly different from that of the control group (GG/GD/DD rates were 43.0%/39.3%/17.7% and 55.6%/36.3%/8.1% for the endometriosis and control groups, respectively). Further subgroup analyses according to the stage of endometriosis also revealed a positive association between the IRS2 DD genotype expression and stage III-IV endometriosis patients in the population studied.


CONCLUSIONS
These results suggest that the IRS2 G1057D polymorphism may be associated with an increased risk for endometriosis.
Cayan
Filiz
F
Department of Obstetrics and Gynecology, University of Mersin School of Medicine, Mersin, Turkey. filizcayan@yahoo.com
Ertunç
Devrim
D
Aras-Ateş
Nurcan
N
Ayaz
Lokman
L
Akbay
Esen
E
Karakaş
Sevim
S
Coban
Ozgür
O
Dilek
Saffet
S
D000328:Adult; D016022:Case-Control Studies; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D055504:Insulin Receptor Substrate Proteins / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D012720:Severity of Illness Index; D014591:Uterine Diseases / Q000235:genetics*
D055504:Insulin Receptor Substrate Proteins