Cryptococcosis in children.
Cryptococcosis is a systemic-opportunistic mycosis caused by two species of the encapsulated yeast-like organism, Cryptococcus neoformans and C. gattii, which cause infection in immunocompromised individuals and in immunologically normal hosts, respectively. Most susceptible to infection are patients with T-cell deficiencies. The spectrum of disease ranges from asymptomatic pulmonary lesions to disseminated infection with meningoencephalitis. After the emergence of AIDS, cryptococcal infections have become much more common. The mycosis occurs less frequently in children than in adults. The purpose of this article is to discuss the aetiology, clinical presentation, predisposing conditions and outcomes in cases of cryptococcosis in children. Emphasis is placed upon paediatric cases occuring in Brazil and in particular to highlight the difference between cases diagnosed in Porto Alegre (South - subtropical climate) and in Belem (North - equatorial climate).
Severo
Cecília Bittencourt
CB
Laboratório de Micologia da Santa Casa Complexo Hospitalar de Porto Alegre, Brazil. cicasevero@hotmail.com
Xavier
Melissa Orzechowski
MO
Gazzoni
Alexandra Flávia
AF
Severo
Luiz Carlos
LC
D001938:Brazil / Q000453:epidemiology; D002648:Child; D003453:Cryptococcosis / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D006801:Humans; D016867:Immunocompromised Host