title: A comparative study between corresponding structural geometric variables using 2 commonly implemented hip structural analysis algorithms applied to dual-energy X-ray absorptiometry images.
abstract: Hip structural analysis (HSA) has been developed over 20 yr, applied extensively in research, and has demonstrated useful outcomes associating bone structural geometry with bone fragility (research-HSA or r-HSA). In 2007, Hologic Inc. (Bedford, MA) incorporated HSA with some modifications as an option for Hologic dual-energy X-ray absorptiometry (DXA) scanners (clinical HSA or c-HSA). This brought HSA from the research environment into the clinical environment. This article reports a comparison of r-HSA and c-HSA implementations using DXA scans from a group of 191 females. Bland-Altman plots at the narrow-neck (NN) HSA region indicated higher r-HSA areal bone mineral density (mean difference: 0.27 g/cm(2); 21.7% [of mean]); cross-sectional area (0.63 cm(2); 18.7%); cross-sectional moment of inertia (0.26 cm(4); 11.1%), and section modulus (0.22 cm(3); 14.5%) compared with c-HSA. The converse was observed for NN subperiosteal width (-0.09 cm; 3.1%). High linear correlations (r(2) > 0.81) were found between r-HSA and c-HSA NN structural geometric outcomes, with the exception of neck shaft angle (r(2) > 0.47). As differences were significant (p < 0.001), slopes and intercepts are provided to enable linear transformations from r-HSA to corresponding c-HSA structural geometric data.
authors.affiliation: Department of Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
authors.forename: Benjamin C C
authors.initials: BC
authors.lastname: Khoo
authors.forename: Scott G
authors.initials: SG
authors.lastname: Wilson
authors.forename: Graeme K
authors.initials: GK
authors.lastname: Worth
authors.forename: Ursula
authors.initials: U
authors.lastname: Perks
authors.forename: Emad
authors.initials: E
authors.lastname: Qweitin
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Spector
authors.forename: Roger I
authors.initials: RI
authors.lastname: Price
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods*; D000328:Adult; D000465:Algorithms; D015519:Bone Density / Q000502:physiology*; D001330:Electronic Data Processing / Q000379:methods*; D005260:Female; D006801:Humans; D010024:Osteoporosis / Q000175:diagnosis; D010384:Pelvic Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D015203:Reproducibility of Results; D012307:Risk Factors