title: Influence of Mg doping on the early steps of physico-chemical reactivity of sol-gel derived bioactive glasses in biological medium.
abstract: The aim of this study is to highlight the influence of magnesium doping on the surface reactivity of binary (SiO(2)-CaO) and ternary (SiO(2)-CaO-P(2)O(5)) bioactive glasses, prepared by sol-gel chemistry, in biological conditions. These materials were produced in powder form, and their compositional and textural properties characterized. They were then soaked in biological fluids for different delays from 0 to 4 days. The surface changes were characterized using Particles Induced X-ray Emission (PIXE) associated with Rutherford Backscattering Spectroscopy (RBS), which are efficient methods for multi-elemental analysis. Elemental maps of major and trace elements were obtained at a micrometer scale and revealed the formation of a calcium phosphate-rich layer after a few days of interaction. We demonstrate that the presence of magnesium in the material has an impact on the development and the formation rate of the bone-like apatite layer.
authors.affiliation: Clermont Université, UBP, LPC, F-63177 Aubière, France.
authors.forename: J
authors.initials: J
authors.lastname: Soulié
authors.forename: J M
authors.initials: JM
authors.lastname: Nedelec
authors.forename: E
authors.initials: E
authors.lastname: Jallot
mesh_terms: D003470:Culture Media; D005782:Gels; D008274:Magnesium / Q000737:chemistry*
chemical_list: D003470:Culture Media; D005782:Gels; D008274:Magnesium