Intrahepatic cholangiocarcinoma progression: prognostic factors and basic mechanisms.
In this review, we will examine various molecular biomarkers for their potential to serve as independent prognostic factors for predicting survival outcome in postoperative patients with progressive intrahepatic cholangiocarcinoma. Specific rodent models of intrahepatic cholangiocarcinoma that mimic relevant cellular, molecular, and clinical features of the human disease are also described, not only in terms of their usefulness in identifying molecular pathways and mechanisms linked to cholangiocarcinoma development and progression, but also for their potential value as preclinical platforms for suggesting and testing novel molecular strategies for cholangiocarcinoma therapy. Last, recent studies aimed at addressing the role of desmoplastic stroma in promoting intrahepatic cholangiocarcinoma progression are highlighted in an effort to underline the potential value of targeting tumor stromal components together with that of cholangiocarcinoma cells as a novel therapeutic option for this devastating cancer.
Sirica
Alphonse E
AE
Division of Cellular and Molecular Pathogenesis, Department of Pathology, Virginia Commonwealth University School of Medicine, Medical College of Virginia Campus, Richmond, Virginia 23298-0297, USA. asirica@mcvh-vcu.edu
Dumur
Catherine I
CI
Campbell
Deanna J W
DJ
Almenara
Jorge A
JA
Ogunwobi
Olorunseun O
OO
Dewitt
Jennifer L
JL
D000818:Animals; D015415:Biomarkers; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D012377:Rodentia
D015415:Biomarkers