Genetic factors in temporal lobe epilepsy.
Genetic investigation of 74 patients with temporal lobe epilepsy, resistant to medication, who underwent unilateral temporal lobectomy 1960-1969. Thirty per cent had a positive family history of epilepsy; 49 per cent of other neurological diseases; and 46 per cent of major psychiatric disorders. Neither of the genetic factors per se influenced the therapeutic result or the psychiatric status at follow-up. A multiple epileptic or neurological predisposition affecting first degree relatives unfavourably influenced the prognosis regarding relief from seizures. A multiple psychiatric predisposition in parents and/or siblings unfavourably influenced the psychiatric status.
Jensen
I
I
University Clinic of Neurosurgery, Rigshospitalet, Copenhagen, Denmark.
D038481:Anterior Temporal Lobectomy; D000927:Anticonvulsants / Q000627:therapeutic use; D001927:Brain Diseases / Q000453:epidemiology / Q000235:genetics / Q000601:surgery; D015897:Comorbidity; D003718:Denmark; D004351:Drug Resistance; D004833:Epilepsy, Temporal Lobe / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D001523:Mental Disorders / Q000453:epidemiology / Q000235:genetics / Q000601:surgery; D011379:Prognosis; D016896:Treatment Outcome
D000927:Anticonvulsants