title: Detection and prediction of local recurrence of maxillary sinus cancer using F-18 FDG PET/CT.
abstract: OBJECTIVE
  The aim of the current study was to investigate the role of F-18 FDG PET/CT in the detection and prediction of local recurrence of maxillary sinus cancer.
  
  
  METHODS
  Retrospectively, we analyzed F-18 FDG PET/CT images of maxillary sinus cancer patients for the surveillance after treatment. Twenty-two consecutive patients with maxillary sinus cancer, who underwent maxillectomy followed by adjuvant radiation treatment, were included in the study. F-18 FDG PET/CT images were analyzed visually and quantitatively.
  
  
  RESULTS
  The median age of the patients included in the current study population was 54.5 years (range, 35-78). Seven patients (29.1%) had local recurrent diseases. Recurrent diseases show statistically significant higher values in SUV(max) (recurrent: 5.09 +/- 3.3, non-recurrent; 3.05 +/- 0.7, p < 0.05), L/NL (recurrent: 2.95 +/- 0.9, non-recurrent; 1.86 +/- 0.5, p < 0.05), L/Ao (recurrent: 3.37 +/- 2.1: non-recurrent; 1.88 +/- 0.4, p < 0.05), and L/Cbr (recurrent: 1.06 +/- 0.7: non-recurrent; 0.46 +/- 0.1, p < 0.05) than those of non-recurrent disease of maxillary sinus cancer. There were no statistical differences between visual assessment and quantitative indices for the detection of local recurrence. The visual assessment was the potent predictor by logistic regression analysis for prediction of local recurrence.
  
  
  CONCLUSIONS
  The visual assessment of F-18 FDG uptake pattern was potential predictor for local recurrence of maxillary sinus cancer. However, the diagnostic performances were similar between visual assessment and quantitative indices. Further studies are needed to confirm these results and improve statistical accuracy.
authors.affiliation: Department of Otorhinolaryngology, Pusan National University School of Medicine, South Korea.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Rho
authors.forename: S-J
authors.initials: SJ
authors.lastname: Kim
authors.forename: H Y
authors.initials: HY
authors.lastname: Nam
authors.forename: B S
authors.initials: BS
authors.lastname: Kim
authors.forename: I J
authors.initials: IJ
authors.lastname: Kim
authors.forename: Y-K
authors.initials: YK
authors.lastname: Kim
authors.forename: K
authors.initials: K
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000601:surgery; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D012372:ROC Curve; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18