Maxillofacial reconstruction using custom-made artificial bones fabricated by inkjet printing technology.
Ideally, artificial bones should be dimensionally compatible with deformities, and be biodegradable and osteoconductive; however, there are no artificial bones developed to date that satisfy these requirements. We fabricated novel custom-made artificial bones from alpha-tricalcium phosphate powder using an inkjet printer and implanted them in ten patients with maxillofacial deformities. The artificial bones had dimensional compatibility in all the patients. The operation time was reduced due to minimal need for size adjustment and fixing manipulation. The postsurgical computed tomography analysis detected partial union between the artificial bones and host bone tissues. There were no serious adverse reactions. These findings provide support for further clinical studies of the inkjet-printed custom-made artificial bones.
Saijo
Hideto
H
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Igawa
Kazuyo
K
Kanno
Yuki
Y
Mori
Yoshiyuki
Y
Kondo
Kayoko
K
Shimizu
Koutaro
K
Suzuki
Shigeki
S
Chikazu
Daichi
D
Iino
Mitsuki
M
Anzai
Masahiro
M
Sasaki
Nobuo
N
Chung
Ung-il
UI
Takato
Tsuyoshi
T
D000293:Adolescent; D000328:Adult; D001187:Artificial Organs; D001672:Biocompatible Materials; D018786:Bone Substitutes; D001842:Bone and Bones; D002130:Calcium Phosphates; D017076:Computer-Aided Design; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008297:Male; D019767:Maxillofacial Abnormalities / Q000601:surgery*; D008446:Maxillofacial Injuries / Q000209:etiology / Q000601:surgery*; D019931:Maxillofacial Prosthesis Implantation; D008875:Middle Aged; D011327:Printing; D019651:Plastic Surgery Procedures; D055815:Young Adult
D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate