title: Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease.
abstract: The proneural protein Neurogenin 2 (NEUROG2) is a transcription factor of importance for the differentiation and survival of midbrain dopaminergic neurons. To determine whether genetic variation in the coding region of the NEUROG2 gene plays a role in the etiology of Parkinson's disease (PD), we screened DNA samples from 202 PD patients and 201 normal controls. No mutation in the NEUROG2 gene was identified in our PD cohort, except that novel compound heterozygous variants (Gly56Arg and Asp206Glu) were found in a 91-year normal male, suggesting that mutations in the coding region of the NEUROG2 gene play little or no role in the development of PD.
authors.affiliation: Center for Experimental Medicine and Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Deng
authors.forename: Hao
authors.initials: H
authors.lastname: Deng
authors.forename: Weidong
authors.initials: W
authors.lastname: Le
authors.forename: Hongbo
authors.initials: H
authors.lastname: Xu
authors.forename: Huarong
authors.initials: H
authors.lastname: Yang
authors.forename: Xiong
authors.initials: X
authors.lastname: Deng
authors.forename: Hongwei
authors.initials: H
authors.lastname: Lv
authors.forename: Wenjie
authors.initials: W
authors.lastname: Xie
authors.forename: Shaihong
authors.initials: S
authors.lastname: Zhu
authors.forename: Joseph
authors.initials: J
authors.lastname: Jankovic
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D009419:Nerve Tissue Proteins; C491183:NEUROG2 protein, human