title: Alternative solvent-free methodologies in the synthesis of pharmaceutical drugs.
abstract: Efforts made by chemists to develop more sustainable processes have resulted in a large increase in greener technologies. Because solvents comprise greater than 80% by mass of a pharmaceutical batch process, the incorporation of solvent-free reactions is expected to significantly reduce the quantity of hazardous waste that is generated during these processes. This review highlights a diverse set of solvent-free organic reactions that can be employed in the development of various pharmaceutical drugs.
authors.affiliation: University of Cincinnati, 301 Clifton Court, Cincinnati, OH 45220, USA.
authors.forename: William C
authors.initials: WC
authors.lastname: Shearouse
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Waddell
authors.forename: James
authors.initials: J
authors.lastname: Mack
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D055772:Green Chemistry Technology / Q000379:methods*; D008956:Models, Chemical; D015394:Molecular Structure; D012997:Solvents; D013678:Technology, Pharmaceutical / Q000295:instrumentation
chemical_list: D012997:Solvents