Intraspecific polymorphism to interspecific divergence: genetics of pigmentation in Drosophila.
Genetic changes contributing to phenotypic differences within or between species have been identified for a handful of traits, but the relationship between alleles underlying intraspecific polymorphism and interspecific divergence is largely unknown. We found that noncoding changes in the tan gene, as well as changes linked to the ebony gene, contribute to pigmentation divergence between closely related Drosophila species. Moreover, we found that alleles linked to tan and ebony fixed in one Drosophila species also contribute to variation within another species, and that multiple genotypes underlie similar phenotypes even within the same population. These alleles appear to predate speciation, which suggests that standing genetic variation present in the common ancestor gave rise to both intraspecific polymorphism and interspecific divergence.
Wittkopp
Patricia J
PJ
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA. wittkopp@umich.edu
Stewart
Emma E
EE
Arnold
Lisa L
LL
Neidert
Adam H
AH
Haerum
Belinda K
BK
Thompson
Elizabeth M
EM
Akhras
Saleh
S
Smith-Winberry
Gabriel
G
Shefner
Laura
L
D000483:Alleles; D000818:Animals; D030801:Animals, Genetically Modified; D001483:Base Sequence; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics* / Q000378:metabolism; D003433:Crosses, Genetic; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D004330:Drosophila / Q000145:classification / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D005786:Gene Expression Regulation; D017344:Genes, Insect; D049810:Genetic Speciation; D005838:Genotype; D007438:Introns; D008297:Male; D008969:Molecular Sequence Data; D010641:Phenotype; D010858:Pigmentation / Q000235:genetics*; D011110:Polymorphism, Genetic; D040641:Quantitative Trait Loci; D013045:Species Specificity
D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C116191:e protein, Drosophila; C431070:t protein, Drosophila