Hypnotic and sleep quality-enhancing properties of kavain in sleep-disturbed rats.
The present study was performed to investigate the effects of kavain on the sleep-wake cycle in comparison with that of rilmazafone and diphenhydramine using sleep-disturbed rats. Electrodes for the electroencephalogram (EEG) and electromyogram (EMG) were implanted into Wistar rats. Total awake time, non-rapid eye movement (non-REM) sleep and rapid eye movement (REM) sleep were measured for 6 h. Kavain and rilmazafone showed a significant shortening in sleep latency, decreased awake time, and increased non-REM sleep time. On the other hand, significant shortening of the sleep latency was observed following the administration of diphenhydramine, while no effects were observed on the awake and non-REM sleep time. Moreover, kavain showed a significant increase in delta activity during non-REM sleep in sleep-disturbed rats, whereas a significant decrease in delta power during non-REM sleep was observed with rilmazafone. These results clearly indicate that kavain is a compound with not only hypnotic effects, but also sleep quality-enhancement effects.
Tsutsui
Ryuki
R
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Shinomiya
Kazuaki
K
Takeda
Yasuhiro
Y
Obara
Yoshihito
Y
Kitamura
Yoshihisa
Y
Kamei
Chiaki
C
D000818:Animals; D003700:Delta Rhythm / Q000187:drug effects; D004155:Diphenhydramine / Q000494:pharmacology; D004569:Electroencephalography / Q000187:drug effects; D004576:Electromyography / Q000187:drug effects; D006993:Hypnotics and Sedatives; D008297:Male; D011753:Pyrones / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects*; D012893:Sleep Wake Disorders / Q000188:drug therapy*; D014230:Triazoles / Q000494:pharmacology; D014851:Wakefulness / Q000187:drug effects
D006993:Hypnotics and Sedatives; D011753:Pyrones; D014230:Triazoles; D004155:Diphenhydramine; C041075:rilmazafone; C011889:kavain