title: Antioxidant Effect of CoQ(10) on N-nitrosodiethylamine-induced Oxidative Stress in Mice.
abstract: The antioxidant effect of CoQ(10) on N-nitrosodiethylamine (NDEA)-induced oxidative stress was investigated in mice. Food intake and body weight were similar in both CoQ(10) and control groups during the 3-week experimental period. NDEA significantly increased the activities of typical marker enzymes of liver function (AST, ALT and ALP) both in control and CoQ(10) groups. However, the increase of plasma aminotransferase activity was significantly reduced in the CoQ(10) group. Lipid peroxidation in various tissues, such as heart, lung, liver, kidney, spleen and plasma, was significantly increased by NDEA, but this increase was significantly reduced by 100 mg/kg of CoQ(10). Superoxide dismutase activity increased significantly upon NDEA-induced oxidative stress in both the control and CoQ(10) groups with the effect being less in the CoQ(10) group. Catalase activity decreased significantly in both the control and CoQ(10) groups treated with NDEA, again with the effect being less in the CoQ(10) group. The lesser effect on superoxide dismutase and catalase in the NDEA-treated CoQ(10) group is indicative of the protective effect CoQ(10). Thus, CoQ(10) can offer useful protection against NDEA-induced oxidative stress.
authors.affiliation: Department of Pathophysiology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Ho Sun
authors.initials: HS
authors.lastname: Song
authors.forename: Hee Rae
authors.initials: HR
authors.lastname: Kim
authors.forename: Tae Wook
authors.initials: TW
authors.lastname: Park
authors.forename: Bong Jae
authors.initials: BJ
authors.lastname: Cho
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Choi
authors.forename: Chang Jong
authors.initials: CJ
authors.lastname: Kim
authors.forename: Uy Dong
authors.initials: UD
authors.lastname: Sohn
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Sim