Evaluation of azithromycin resistance in Treponema pallidum specimens from Madagascar.
Treponema pallidum resistance to azithromycin has been documented in the US, Canada, and Ireland. We found no evidence of resistance to azithromycin in specimens from 141 patients with syphilitic lesions in Madagascar suggesting resistance is geographically isolated and supporting use of azithromycin as alternative treatment for early syphilis in Madagascar.
Van Damme
Kathleen
K
Department of Medicine, Division of Infectious Diseases, University of North Carolina, Madagascar (UNC-MAD), Antananarivo, Madagascar.
Behets
Frieda
F
Ravelomanana
Noro
N
Godornes
Charmie
C
Khan
Maria
M
Randrianasolo
Bodo
B
Rabenja
Ny Lovaniaina
NL
Lukehart
Sheila
S
Cohen
Myron
M
Hook
Edward
E
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017963:Azithromycin / Q000494:pharmacology* / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005260:Female; D006801:Humans; D008270:Madagascar / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009154:Mutation; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D013587:Syphilis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D014210:Treponema pallidum / Q000187:drug effects* / Q000235:genetics; D055815:Young Adult
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D012338:RNA, Ribosomal, 23S; D017963:Azithromycin