Improved method for the synthesis of beta-carbonyl silyl-1,3-dithianes by the double conjugate addition of 1,3-dithiol to propargylic carbonyl compounds.
Base-mediated double conjugate addition of 1,3-propane dithiol to various silylated propargylic aldehydes and ketones allows for an efficient and scalable synthesis of beta-carbonyl silyl-1,3-dithianes.
Mukherjee
Sumit
S
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, USA.
Kontokosta
Dimitra
D
Patil
Aditi
A
Rallapalli
Sivakumar
S
Lee
Daesung
D
D000447:Aldehydes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D008722:Methods; D011807:Quinolizines / Q000138:chemical synthesis*; D012821:Silanes; D013457:Sulfur Compounds / Q000138:chemical synthesis*; D014050:Toluene / Q000031:analogs & derivatives / Q000737:chemistry
D000447:Aldehydes; D000480:Alkynes; D007659:Ketones; D011807:Quinolizines; D012821:Silanes; D013457:Sulfur Compounds; C438055:dithiane; D014050:Toluene; C004848:dithiol