title: Clinical utility of NT-proBNP levels in late heart transplantation patients.
abstract: BACKGROUND
  The present work was aimed to describe NT-proBNP levels in heart transplant patients after the first year postsurgery.
  
  
  METHODS
  NT-proBNP concentration was measured in 1231 samples from 142 patients when a routine four-month follow-up was carried out, including other biochemical and clinical examinations. Endomyocardial biopsies were performed only upon clinical suspicion of acute rejection.
  
  
  RESULTS
  NT-proBNP concentrations were not significantly correlated to post-transplantation time, though differences were observed according to clinical symptoms (Kruskal-Wallis test, p<0.001). Although multivariate analysis revealed statistically significant association between NT-proBNP concentration and some qualitative (cardiac allograft vasculopathy-CAV-, sex, diabetes) and quantitative (creatinine, hematocrit, age) variables, only moderately relevant contribution was observed for creatinine and CAV. Patients with rejection showed noticeable increases in serum NT-proBNP concentrations, above more than 2.5 times the reference change value (97%). NT-proBNP concentrations higher than 1000ng/L increased in 3.5 times (95%CI: 2.4-5) the risk of death in less than one year.
  
  
  CONCLUSIONS
  After the first year from surgery, NT-proBNP concentrations were not associated to post-transplantation time and NT-proBNP could be a useful diagnostic marker for rejection, whenever serial measurements are made. A NT-proBNP cutoff value of 1000ng/L was identified for classifying patients at risk of death after one year.
authors.affiliation: Servicio de Bioquímica Clínica, Hospital Universitario Central de Asturias, Oviedo, Spain.
authors.forename: Noelia
authors.initials: N
authors.lastname: Avello
authors.forename: Belén
authors.initials: B
authors.lastname: Prieto
authors.forename: Beatriz D
authors.initials: BD
authors.lastname: Molina
authors.forename: Jose L
authors.initials: JL
authors.lastname: Rodriguez-Lambert
authors.forename: Francisco V
authors.initials: FV
authors.lastname: Alvarez
mesh_terms: D000368:Aged; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D011184:Postoperative Period; D011379:Prognosis; D013997:Time Factors
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain