title: Malignant transformation of extragonadal endometriosis: a case report.
abstract: Though malignant transformation of endometriosis has been documented, malignancy arising from extragonadal endometriosis is rare. We present the case of a 39-year-old woman with abdominal pain and fullness after menstruation. Evaluation revealed a cul-de-sac mass and CA-125 level of 1048 U/ml. A hysterectomy, bilateral salpingo-oophorectomy, and omentectomy were performed. Endometrioid adenocarcinoma with a clearly defined transition zone from endometriosis to adenocarcinoma was noted histologically. Adjuvant chemotherapy and GnRH agonist treatment was administered. Serum CA-125 level was 1.51 U/ml 19 months after completion of treatment. Patients with endometriosis and elevated CA-125 levels should be managed aggressively and CA-125 levels monitored until they have normalized.
authors.affiliation: Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan.
authors.forename: W C
authors.initials: WC
authors.lastname: Wu
authors.forename: M W
authors.initials: MW
authors.lastname: Hsiao
authors.forename: J C
authors.initials: JC
authors.lastname: Ye
authors.forename: Y C
authors.initials: YC
authors.lastname: Hung
authors.forename: W C
authors.initials: WC
authors.lastname: Chang
mesh_terms: D000328:Adult; D018269:Carcinoma, Endometrioid / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D004715:Endometriosis / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000473:pathology*