Fewer adverse effects with doxycycline than with minocycline.
(1) In mid-2008 the French National Pharmacovigilance Committee examined spontaneous reports of adverse effects observed during tetracycline therapy; (2) When sales figures are taken into account, reports were more frequent with minocycline than with doxycycline. The proportion of severe adverse effects was also higher with minocycline than with doxycycline; (3) Life-threatening hypersensitivity reactions and autoimmune adverse effects were more frequent with minocycline than with doxycycline; (4) In practice, minocycline has a less favourable risk-benefit balance than doxycycline, particularly in the treatment of acne.
D000152:Acne Vulgaris / Q000188:drug therapy*; D001327:Autoimmune Diseases / Q000139:chemically induced; D004318:Doxycycline / Q000009:adverse effects* / Q000627:therapeutic use / Q000633:toxicity; D004342:Drug Hypersensitivity; D064420:Drug-Related Side Effects and Adverse Reactions; D005602:France; D006801:Humans; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use / Q000633:toxicity
D008911:Minocycline; D004318:Doxycycline