title: Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population.
abstract: Alpha-synuclein gene (SNCA) mutations cause familial Parkinsonism but the role of SNCA variability in idiopathic Parkinson's disease (PD) remains incompletely defined. We report a study of SNCA genetic variation in 452 idiopathic PD cases and 245 controls. SNCA copy number mutations were not associated with early-onset disease in this population. The minor allele "G" at rs356165 was associated with increased odds of PD (P = 0.013) and genetic variation in D4S3481 (Rep1) was associated with age of disease onset (P = 0.007). There was a trend toward association between variation at rs2583988 and rapid PD progression.
authors.affiliation: Division of Neurology, University of Saskatchewan and Saskatoon Health Region, Saskatoon, Saskatchewan, Canada.
authors.forename: Alex
authors.initials: A
authors.lastname: Rajput
authors.forename: Carles
authors.initials: C
authors.lastname: Vilariño-Güell
authors.forename: Michele L
authors.initials: ML
authors.lastname: Rajput
authors.forename: Owen A
authors.initials: OA
authors.lastname: Ross
authors.forename: Alexandra I
authors.initials: AI
authors.lastname: Soto-Ortolaza
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Lincoln
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Cobb
authors.forename: Michael G
authors.initials: MG
authors.lastname: Heckman
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Farrer
authors.forename: Ali
authors.initials: A
authors.lastname: Rajput
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D016017:Odds Ratio; D010300:Parkinson Disease / Q000235:genetics*; D012525:Saskatchewan / Q000453:epidemiology / Q000208:ethnology; D051844:alpha-Synuclein / Q000235:genetics*
chemical_list: D051844:alpha-Synuclein