title: Catalysis of fluorine addition to double bond: an improvement of method for synthesis of (18)F PET agents.
abstract: Catalysis for reaction of electrophilic fluorine addition to a fluorinated double bond is described. The presence of small amounts of iodine, bromine, or boron trifluoride increases an overall product yield and degree of fluorine incorporation, making the reaction a more efficient method for preparation of (18)F positron emission tomography agents. A possible mechanism of catalytic action of iodine is discussed.
authors.affiliation: Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. kachur@mail.med.upenn.edu
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Kachur
authors.forename: William R
authors.initials: WR
authors.lastname: Dolbier
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Cameron J
authors.initials: CJ
authors.lastname: Koch
mesh_terms: D002384:Catalysis; D005461:Fluorine / Q000737:chemistry*; D019788:Fluorodeoxyglucose F18 / Q000138:chemical synthesis*; D007553:Isotope Labeling / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005461:Fluorine