A review of the effectiveness of antimitotic drug injections for hypertrophic scars and keloids.
Hypertrophic scars and keloids are common problems after injury and cause functional and cosmetic deformities. A wide variety of treatments have been advocated for hypertrophic scars and keloids regression. Unfortunately, the reported efficacy has been variable. This article explores antimitotic drugs described in the literature such as steroid injection, 5-FU, mitomycin C, and bleomycin, which mainly target the fibroblasts in scar tissue, have been proposed as the effective modalities for scar treatment and scar prevention after surgery, but restricted due to possible side effects. The current accepted treatment for hypertrophic scar and keloid are combination therapy and the early treatment which could achieve better efficacy and less adverse effect.
Wang
Xi-Qiao
XQ
Institute of Burn, Ruijin Hospital, Jiaotong University Medical School, Shanghai, People's Republic of China.
Liu
Ying-Kai
YK
Qing
Chun
C
Lu
Shu-Liang
SL
D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D001761:Bleomycin / Q000008:administration & dosage; D017439:Cicatrix, Hypertrophic; D003078:Colchicine / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005347:Fibroblasts / Q000187:drug effects; D005472:Fluorouracil / Q000627:therapeutic use; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D015552:Injections, Intralesional; D007627:Keloid; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use; D050258:Mitosis Modulators / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use; D014221:Triamcinolone / Q000008:administration & dosage
D000964:Antimetabolites, Antineoplastic; D005938:Glucocorticoids; D050258:Mitosis Modulators; D001761:Bleomycin; D014221:Triamcinolone; D016685:Mitomycin; D014212:Tretinoin; D003078:Colchicine; D005472:Fluorouracil