title: Direct metallation of thienopyrimidines using a mixed lithium-cadmium base and antitumor activity of functionalized derivatives.
abstract: A series of thieno[2,3-d]- and thieno[3,2-d]pyrimidines have been easily synthesized using as key step a deproto-cadmiation-trapping sequence. Some of the compounds thus synthesized were screened for anticancer (cytotoxic) activities, and (S)-2-(6-iodo-2-phenylthieno[2,3-d]pyrimidin-4-ylamino)-3-phenylpropanoic acid proved to have a significant activity towards liver, human breast and cervix carcinoma cell lines.
authors.affiliation: Chimie et Photonique Moléculaires, UMR 6510 CNRS, Université de Rennes 1, Bâtiment 10A, Case 1003, Campus Scientifique de Beaulieu, 35042, Rennes, France.
authors.forename: Katia
authors.initials: K
authors.lastname: Snégaroff
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lassagne
authors.forename: Ghenia
authors.initials: G
authors.lastname: Bentabed-Ababsa
authors.forename: Ekhlass
authors.initials: E
authors.lastname: Nassar
authors.forename: Sidaty Cheikh Sid
authors.initials: SC
authors.lastname: Ely
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Hesse
authors.forename: Enrico
authors.initials: E
authors.lastname: Perspicace
authors.forename: Aïcha
authors.initials: A
authors.lastname: Derdour
authors.forename: Florence
authors.initials: F
authors.lastname: Mongin
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D002104:Cadmium / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D054879:Halogenation / Q000187:drug effects; D006801:Humans; D008094:Lithium / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011743:Pyrimidines; C476003:thienopyrimidine; D002104:Cadmium; D004317:Doxorubicin; D008094:Lithium