title: In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin.
abstract: In vitro activity of fosfomycin was evaluated against 68 bla(KPC)-possessing Klebsiella pneumoniae (KpKPC) isolates, including 23 tigecycline- and/or colistin-nonsusceptible strains. By agar dilution, 93% of the overall KpKPC were susceptible (MIC(50/90) of 16/64 microg/ml, respectively). The subgroup of 23 tigecycline- and/or colistin-nonsusceptible strains showed susceptibility rates of 87% (MIC(50/90) of 32/128 microg/ml, respectively). Notably, 5 out of 6 extremely drug-resistant (tigecycline and colistin nonsusceptible) KpKPC were susceptible to fosfomycin. Compared to agar dilution, disk diffusion was more accurate than Etest.
authors.affiliation: Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. aendimiani@gmail.com
authors.forename: Andrea
authors.initials: A
authors.lastname: Endimiani
authors.forename: Gopi
authors.initials: G
authors.lastname: Patel
authors.forename: Kristine M
authors.initials: KM
authors.lastname: Hujer
authors.forename: Mahesh
authors.initials: M
authors.lastname: Swaminathan
authors.forename: Federico
authors.initials: F
authors.lastname: Perez
authors.forename: Louis B
authors.initials: LB
authors.lastname: Rice
authors.forename: Michael R
authors.initials: MR
authors.lastname: Jacobs
authors.forename: Robert A
authors.initials: RA
authors.lastname: Bonomo
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003091:Colistin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005578:Fosfomycin / Q000494:pharmacology*; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D010641:Phenotype; D000078304:Tigecycline; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D000078304:Tigecycline; C434283:beta-lactamase KPC-1; D001618:beta-Lactamases; D008911:Minocycline; D003091:Colistin