Common PCSK1 haplotypes are associated with obesity in the Chinese population.
Prohormone convertase subtilisin/kexin type 1 (PCSK1) genetic polymorphisms have recently been associated with obesity in European populations. This study aimed to examine whether common PCSK1 genetic variation is associated with obesity and related metabolic phenotypes in the Chinese population. We genotyped nine common tag single-nucleotide polymorphisms (tagSNP) of the PCSK1 gene in 1,094 subjects of Chinese origin from the Stanford Asia-Pacific Program for Hypertension and Insulin Resistance (SAPPHIRe) family study. One SNP in the PCSK1 gene (rs155971) were nominally associated with risk of obesity in the SAPPHIRe cohort (P = 0.01). A common protective haplotype was associated with reduced risk of obesity (23.79% vs. 32.89%, P = 0.01) and smaller waist circumference (81.71 +/- 10.22 vs. 84.75 +/- 10.48 cm, P = 0.02). Another common haplotype was significantly associated with increased risk of obesity (37.07% vs. 23.84%, P = 0.005). The global P value for haplotype association with obesity was 0.02. We also identified a suggestive association of another PCSK1 SNP (rs3811951) with fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA(IR)), triglycerides, and high-density lipoprotein cholesterol (P = 0.05, 0.003, 0.001, 0.04, and 0.04, respectively). These data indicate common PCSK1 genetic variants are associated with obesity in the Chinese population.
Chang
Yi-Cheng
YC
Department of Internal Medicine, National Taiwan University Hospital Yunlin branch, Yunlin, Taiwan.
Chiu
Yen-Feng
YF
Shih
Kuang-Chung
KC
Lin
Ming-Wei
MW
Sheu
Wayne Huey-Herng
WH
Donlon
Timothy
T
Curb
Jess David
JD
Jou
Yuh-Shan
YS
Chang
Tien-Jyun
TJ
Li
Hung-Yuan
HY
Chuang
Lee-Ming
LM
D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data*; D005091:Exons / Q000235:genetics; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D007438:Introns / Q000235:genetics; D008055:Lipids / Q000097:blood; D009765:Obesity / Q000208:ethnology* / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D045664:Proprotein Convertase 1 / Q000235:genetics*; D012307:Risk Factors
D008055:Lipids; D045664:Proprotein Convertase 1