Peripheral arterial thrombosis with presence of anti-centromere antibodies and polycythemia vera.
Digital gangrene due to arterial thrombosis can occur due to a variety of causes. There have been reports of patients who have presented with digital gangrene with no known predisposing factors, but with positive anti-centromere antibodies (ACA). Despite that they did not have features suggestive of disorders like Scleroderma or CREST syndrome. We report a patient with digital gangrene, who was asymptomatic before this episode and was found to have both ACA positivity and Polycythemia Vera.
Pillai
Unnikrishnan
U
Internal Medicine Residency Program, St. Mary's Health Center, St. Louis, unnikrishnanpk@yahoo.com
Muzaffar
Jameel
J
Uppaluri
Chitra
C
D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D002503:Centromere / Q000276:immunology*; D005260:Female; D005385:Fingers / Q000098:blood supply*; D005734:Gangrene / Q000209:etiology; D006801:Humans; D011087:Polycythemia Vera / Q000150:complications* / Q000276:immunology*; D013927:Thrombosis / Q000150:complications*
D001323:Autoantibodies