title: Does trocar-guided tension-free vaginal mesh (Prolift) repair provoke prolapse of the unaffected compartments?
abstract: OBJECTIVE
  The objective of this study was to assess the effect of the tension-free vaginal mesh (Prolift) procedure on the non-treated and initially unaffected vaginal compartments.
  
  
  METHODS
  This prospective observational cohort study involved 150 patients who underwent a Prolift procedure. Pelvic organ prolapse (POP) quantification and evaluation of prolapse symptoms with validated questionnaires was performed pre-operatively and 6 and 12 months postoperatively. Primary outcome was the rate of POP stage > or = II in the non-treated vaginal compartments.
  
  
  RESULTS
  Twenty-three percent of all patients developed a de novo POP stage > or = II in the untreated compartment. This occurred in 46% and 25% of patients after an isolated anterior and isolated posterior Prolift, respectively.
  
  
  CONCLUSIONS
  Tension-free vaginal mesh treatment of one vaginal compartment seems to provoke the development of vaginal prolapse in initially unaffected vaginal compartments, particularly after an isolated anterior Prolift procedure.
authors.affiliation: Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, 791, Secretariaat Obstetrie and Gynaecologie, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. m.withagen@obgyn.umcn.nl
authors.forename: Mariëlla I J
authors.initials: MI
authors.lastname: Withagen
authors.forename: Mark E
authors.initials: ME
authors.lastname: Vierhout
authors.forename: Alfredo L
authors.initials: AL
authors.lastname: Milani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008875:Middle Aged; D056887:Pelvic Organ Prolapse / Q000209:etiology* / Q000601:surgery; D011446:Prospective Studies; D053825:Suburethral Slings / Q000009:adverse effects*; D016896:Treatment Outcome