title: Molecular mechanisms of enterotoxigenic Escherichia coli infection.
abstract: Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in developing countries, and perennially the most common cause of traveller's diarrhea. ETEC constitute a diverse pathotype that elaborate heat-labile and/or heat-stable enterotoxins. Recent molecular pathogenesis studies reveal sophisticated pathogen-host interactions that might be exploited in efforts to prevent these important infections. While vaccine development for these important pathogens remains a formidable challenge, extensive efforts that attempt to exploit new genomic and proteomic technology platforms in discovery of novel targets are presently ongoing.
authors.affiliation: Medicine Service Veterans Affairs Medical Center, Memphis, TN 38104, USA. jflecke1@tennessee.edu
authors.forename: James M
authors.initials: JM
authors.lastname: Fleckenstein
authors.forename: Philip R
authors.initials: PR
authors.lastname: Hardwidge
authors.forename: George P
authors.initials: GP
authors.lastname: Munson
authors.forename: David A
authors.initials: DA
authors.lastname: Rasko
authors.forename: Halvor
authors.initials: H
authors.lastname: Sommerfelt
authors.forename: Hans
authors.initials: H
authors.lastname: Steinsland
mesh_terms: D018830:Adhesins, Escherichia coli / Q000378:metabolism; D001428:Bacterial Vaccines; D004403:Dysentery / Q000382:microbiology; D054307:Enterotoxigenic Escherichia coli / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology*; D010861:Fimbriae, Bacterial / Q000378:metabolism; D006801:Humans; D034982:Integration Host Factors; D007421:Intestine, Small / Q000382:microbiology; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors / Q000737:chemistry / Q000378:metabolism
chemical_list: D018830:Adhesins, Escherichia coli; D001428:Bacterial Vaccines; D034982:Integration Host Factors; D037521:Virulence Factors