title: Highly enantioselective Rh-catalyzed hydrogenation of beta,gamma-unsaturated phosphonates with chiral ferrocene-based monophosphoramidite ligands.
abstract: An enantioselective synthesis of chiral alkylphosphonates bearing a beta-stereogenic center, based on the Rh-catalyzed asymmetric hydrogenation of corresponding beta-substituted beta,gamma-unsaturated phosphonates with a ferrocene-based monophosphoramidite ligand under the mild hydrogenation conditions, was developed, in which an ee value of up to 98% was obtained.
authors.affiliation: Dalian Institute of Chemical physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.
authors.forename: Zheng-Chao
authors.initials: ZC
authors.lastname: Duan
authors.forename: Xiang-Ping
authors.initials: XP
authors.lastname: Hu
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.forename: Dao-Yong
authors.initials: DY
authors.lastname: Wang
authors.forename: Sai-Bo
authors.initials: SB
authors.lastname: Yu
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Zheng
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D005296:Ferrous Compounds / Q000737:chemistry; D006865:Hydrogenation; D008024:Ligands; D000075163:Metallocenes; D063065:Organophosphonates / Q000737:chemistry*; D010756:Phosphoric Acids / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D005296:Ferrous Compounds; D008024:Ligands; D000075163:Metallocenes; D063065:Organophosphonates; D010756:Phosphoric Acids; C011067:phosphoramidic acid; D012238:Rhodium; C004998:ferrocene