Click chemistry with lanthanide complexes: a word of caution.
A propargyl-appended Eu(III) complex shows unanticipated reactivity towards NaN(3) in the Cu(I) catalysed click reaction yielding an unsubstituted 1,2,3-triazole. The resulting complex exhibits pH-responsive (1)H NMR and Eu(III) luminescence behaviour in the physiological pH range consistent with deprotonation of the NH-acidic bound triazole.
Stasiuk
Graeme J
GJ
Department of Chemistry, University of Leicester, University Road, Leicester, UKLE1 7RH.
Lowe
Mark P
MP
D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D005063:Europium / Q000737:chemistry*; D049449:Luminescence; D008279:Magnetic Resonance Imaging; D014230:Triazoles / Q000737:chemistry*
D003287:Contrast Media; D056831:Coordination Complexes; D014230:Triazoles; D005063:Europium