[Activity of aldehyde scavenger enzymes in the heart of rats of different age during immobilized stress].
This study was made to determine the activity of aldehyde scavenger enzymes in the heart's postmitochondrial fraction of rats of different age during immobilization stress. Our study demonstrated, that immobilization of 1.5-, 2- and 12-month rats was accompanied by inhibiting activity of aldehyde dehydrogenase and aldehyde reductase. At the same time we observed an increase in glutathione transferase activity in immobilized 1.5-month-old rats and that in reductase activity in 24-month-old rats. The revealed changes can lead to a decrease in the rate of endogenous aldehyde utilization in the heart during stress at puberty.
Grabovetskaia
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ER
Davydov
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D000375:Aging / Q000378:metabolism*; D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D000449:Aldehyde Reductase / Q000378:metabolism; D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D002384:Catalysis; D005982:Glutathione Transferase / Q000378:metabolism; D008297:Male; D008929:Mitochondria, Heart / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology*; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000201:enzymology*
D000447:Aldehydes; D000449:Aldehyde Reductase; D000444:Aldehyde Dehydrogenase; D005982:Glutathione Transferase