title: Rearrangements of the transcriptional regulatory networks of metabolic pathways in fungi.
abstract: Growing evidence suggests that transcriptional regulatory networks in many organisms are highly flexible. Here, we discuss the evolution of transcriptional regulatory networks governing the metabolic machinery of sequenced ascomycetes. In particular, recent work has shown that transcriptional rewiring is common in regulons controlling processes such as production of ribosome components and metabolism of carbohydrates and lipids. We note that dramatic rearrangements of the transcriptional regulatory components of metabolic functions have occurred among ascomycetes species.
authors.affiliation: Biotechnology Research Institute, National Research Council, Montreal, Quebec, H4P 2R2, Canada.
authors.forename: Hugo
authors.initials: H
authors.lastname: Lavoie
authors.forename: Hervé
authors.initials: H
authors.lastname: Hogues
authors.forename: Malcolm
authors.initials: M
authors.lastname: Whiteway
mesh_terms: D001203:Ascomycota / Q000502:physiology*; D050260:Carbohydrate Metabolism; D019143:Evolution, Molecular; D015966:Gene Expression Regulation, Fungal; D050356:Lipid Metabolism; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D012335:RNA, Ribosomal / Q000378:metabolism; D018085:Regulon; D014158:Transcription, Genetic
chemical_list: D012335:RNA, Ribosomal