Synthesis, characterization and antimicrobial studies on cis-platinum(II) complexes of 5-nitrosouracil derivatives.
Two complexes were obtained during the reactions of 6-amino-1-methyl-5-nitrosouracil (AMNU) and 6-methylamino-1-benzyl-5-nitrosouracil (MABNU) with cis-diaquadiamineplatinum(II) nitrate complex, cis-[Pt(NH(3))(2)(H(2)O)(2)](NO(3))(2). The complexes were isolated in good yields as powdery precipitates. They were characterized through their elemental analysis, infrared, UV-vis, and (1)H NMR spectroscopies as well as thermal analyses. The obtained results indicated that, pyrimidine bases substitute easily aqua ligands and interact with Pt(II) ions as a monodentate ligand in the neutral and ionic form for the ligands AMNU and MABNU, respectively. The exocyclic oxygen atoms are the most probable binding site. Square planar structures, cis-form, were proposed in both cases. The free ligands, and their Pt(II) complexes were screened for their antimicrobial activities.
Gaballa
Akmal S
AS
Faculty of Specific Education, Zagazig University, Zagazig, Egypt. akmalsg@hotmail.com
D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D002945:Cisplatin / Q000031:analogs & derivatives / Q000737:chemistry*; D008024:Ligands; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009603:Nitroso Compounds / Q000737:chemistry; D013057:Spectrum Analysis / Q000379:methods; D013818:Thermogravimetry; D014498:Uracil / Q000031:analogs & derivatives / Q000737:chemistry
C498098:6-amino-1-methyl-5-nitrosouracil; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D008024:Ligands; D009603:Nitroso Compounds; C034297:diamminediaqua platinum(II); D014498:Uracil; D002945:Cisplatin