title: The effects of metabolic syndrome and apolipoprotein E4 on cognitive event-related potentials.
abstract: To reduce the care burden of dementia, identifying whether the combined effect of metabolic syndrome and epsilon4 increases the risk of cognitive decline needs to be determined. Using the Cognitive Abilities Screening Instrument (CASI), 145 mentally healthy middle-aged and older adults were recruited to investigate the influence of metabolic syndrome and epsilon4 on cognitive event-related potentials (ERPs). The results showed no difference in CASI scores, N100 and P300 measurements and epsilon4 carrier percentage between participants with and without metabolic syndrome. The epsilon4 carriers displayed a significant decrease in P300 amplitude, although the CASI scores and N100 component showed no difference. We conclude that metabolic syndrome exerts little effect on N100 and P300 measurements, and that epsilon4 carrier is an independent predictor of low P300 amplitude.
authors.affiliation: Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, #100 Tzyou 1st Road, Kaohsiung, Taiwan, ROC.
authors.forename: Chiou-Lian
authors.initials: CL
authors.lastname: Lai
authors.forename: Ruey-Tay
authors.initials: RT
authors.lastname: Lin
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Liou
authors.forename: Chung-Yao
authors.initials: CY
authors.lastname: Hsu
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Hsieh
authors.forename: Ching-Kuan
authors.initials: CK
authors.lastname: Liu
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D053327:Apolipoprotein E4 / Q000235:genetics*; D001794:Blood Pressure / Q000502:physiology; D003072:Cognition Disorders / Q000209:etiology* / Q000235:genetics*; D004569:Electroencephalography / Q000379:methods; D018913:Event-Related Potentials, P300 / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism; D008297:Male; D008659:Metabolic Diseases / Q000150:complications* / Q000235:genetics; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology
chemical_list: D053327:Apolipoprotein E4; D008075:Lipoproteins, HDL