Diffuse neurosarcoidosis involving only the leptomeninges of the brainstem and spinal cord.
MRI findings of sarcoidosis are usually intraparenchymal granuloma with leptomeningeal lesions. This appearance is dependent upon leptomeningeal lesions subsequently infiltrating to parenchyma. We describe a 52-year-old man with slowly progressive paresthesias and weakness in his legs. MRI showed diffuse leptomeningeal lesions throughout the brainstem and spinal cord without intraparenchymal lesions. A diagnosis of sarcoidosis was confirmed by cervical lymph node biopsy which detected noncaseating granuloma. Only leptomeningeal lesions throughout the brainstem and spinal cord could be observed in sarcoidosis.
Makino
Takahiro
T
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Ito
Shoichi
S
Mori
Masahiro
M
Kuwabara
Satoshi
S
D001706:Biopsy; D001933:Brain Stem / Q000473:pathology*; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000473:pathology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D012507:Sarcoidosis / Q000188:drug therapy / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology*; D016896:Treatment Outcome
D005938:Glucocorticoids; D011239:Prednisolone; D008775:Methylprednisolone