title: A chiron approach to the total synthesis of cytotoxic (+)-muricatacin and (+)-5-epi-muricatacin from D-ribose.
abstract: A chiron approach strategy toward the total synthesis of (+)-muricatacin and (+)-5-epi-muricatacin starting from commercially available and inexpensive d-ribose through the key intermediate (S)-5-((R)-1-hydroxyallyl)furan-2(5H)-one has been disclosed.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226 001, India.
authors.forename: Partha
authors.initials: P
authors.lastname: Ghosal
authors.forename: Vikas
authors.initials: V
authors.lastname: Kumar
authors.forename: Arun K
authors.initials: AK
authors.lastname: Shaw
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry*; D012266:Ribose / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; C082488:muricatacin; D012266:Ribose; C039281:furan