Palladium-catalyzed carbamoylation of aryl halides by tungsten carbonyl amine complex.
In the presence of aminepentacarbonyltungsten, base, and a catalytic amount of palladium(0) complex, carbamoylation of aryl halide proceeds to afford amide. The reaction may involve transmetalation between palladium(II) intermediate and carbamoyltungstenate that is generated in situ. This catalytic cross-coupling reaction provides an alternative method to the conventional palladium-catalyzed amidation by using gaseous carbon monoxide.
Ren
Wei
W
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
Yamane
Motoki
M