Herpetic keratitis and keratouveitis after mitomycin-C use in glaucoma filtering surgery: a short case series.
OBJECTIVE
We report 4 eyes of 3 patients with presumed herpetic keratitis/keratouveitis after glaucoma surgery wherein intraoperative mitomycin-C was used.


METHODS
Three patients, aged 18-75 years, were found to have unilateral or bilateral herpetic keratitis and/or keratouveitis, 15 days to 2 years after trabeculectomy with mitomycin-C.


RESULTS
All 3 cases healed without any sequelae after 4 to 6 weeks with topical and/or systemic acyclovir. Topical steroids were used in cases with stromal involvement.


CONCLUSIONS
Mitomycin-C may predispose/facilitate development of herpetic keratitis/keratouveitis up to 2 years after glaucoma surgery.
Rao
Aparna
A
Glaucoma Services, R.P. Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - India. vinodini10375@yahoo.com
Tandon
Radihika
R
Sharma
Namrata
N
Sihota
Ramanjit
R
Gupta
Viney
V
Dada
Tanuj
T
D000212:Acyclovir / Q000627:therapeutic use; D000293:Adolescent; D000368:Aged; D000477:Alkylating Agents / Q000009:adverse effects; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005260:Female; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016849:Keratitis, Herpetic / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000009:adverse effects*; D018139:Simplexvirus / Q000502:physiology*; D014130:Trabeculectomy; D014606:Uveitis, Anterior / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D014775:Virus Activation / Q000187:drug effects*
D000477:Alkylating Agents; D005938:Glucocorticoids; D016685:Mitomycin; D000212:Acyclovir