Highly recommended dose of MK4 for osteoporosis.
The recommended dose of Menatretenone is 45 mg three times a day; however the compliant in daily practice is not convenient. This study shows the twice dose per day is inferior to the recommended dose. This study used the level of Gla protein in osteocalcin as a parameter for the comparison. The mean of three-time dose a day is 11.27 nanogram per milliliter while the mean of the other group is 6.07 nanogram per milliliter after the three-month treatment.
Bunyaratavej
Narong
N
Department of Orthopaedic Surgery, Siriraj Hospital, Mahidol University, Bangkok, Thailand. todrnarong@yahoo.com
Kittimanon
Nipat
N
Jitivirai
Thunchanok
T
Tongthongthip
Boonsom
B
D000368:Aged; D002118:Calcium / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy*; D016896:Treatment Outcome; D014807:Vitamin D / Q000008:administration & dosage; D024482:Vitamin K 2 / Q000008:administration & dosage / Q000031:analogs & derivatives*
D024482:Vitamin K 2; D014807:Vitamin D; C030814:menatetrenone; D002118:Calcium