title: [Second operation more frequent following breast-conserving treatment for invasive lobular than for invasive non-lobular carcinoma].
abstract: OBJECTIVE
  To establish the frequency of re-excision or mastectomy in women who had breast-conserving treatment for invasive lobular mammary carcinoma.
  
  
  METHODS
  Retrospective.
  
  
  METHODS
  Data on the number of patients with invasive carcinoma from 1998-2006 were obtained from the national pathology database (PALGA) and the Dutch Comprehensive Cancer Centre East. The following data on patients who had undergone breast-conserving treatment for invasive lobular carcinoma were collected from the electronic patient records: age, localization procedure with wire-localisation and tumour size.
  
  
  RESULTS
  The frequency of re-excision or mastectomy following initial breast-conserving surgery in 123 patients with invasive lobular carcinoma was 46.3 % versus 31.5 % in 877 patients with other types of invasive carcinoma. The number of re-excisions was higher in the group with invasive non-lobular carcinoma (4.9% versus 9.2%), and the number of conversions to mastectomy was higher in the group with invasive lobular carcinoma (41.5% versus 20.1%). The age of the patient, the localisation procedure and tumour size were not significant predictors of a tumour-free surgical margin or for the necessity of re-excision.
  
  
  CONCLUSIONS
  The frequency of re-excision in patients with invasive lobular carcinoma was higher than in patients with other types of breast cancer. There was no statistically significant predictor for obtaining a tumour-free surgical margin.
authors.affiliation: Radboud Universitair Medisch Centrum, afdeling Chirurgie, The Netherlands. s.dezeeuw@chir.umcn.nl
authors.forename: Sharonne
authors.initials: S
authors.lastname: de Zeeuw
authors.forename: Frits
authors.initials: F
authors.lastname: Wildenberg
authors.forename: Luc
authors.initials: L
authors.lastname: Strobbe
authors.forename: Theo
authors.initials: T
authors.lastname: Wobbes
mesh_terms: D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D018275:Carcinoma, Lobular / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008408:Mastectomy; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome