First isolation of an H1N1 avian influenza virus from wild terrestrial non-migratory birds in Argentina.
A type A avian influenza (AI) virus was isolated from dead or severely ill red-winged tinamous (Rhynchotus rufescens) found in a hunting ground in April 2008 in Argentina. The subtype of A/red-winged tinamou/Argentina/MP1/2008 was determined as H1N1 by sequence analysis. The cleavage site of the viral hemagglutinin corresponded to a low pathogenic influenza virus, although the clinical presentation and pathological studies suggest that the virus was pathogenic for red-winged tinamous. Phylogenetic analysis of the viral genome suggested that while the hemagglutinin and neuraminidase genes were related to AIV from North America, the internal genes were most closely related to other South American isolates. These findings support the postulated South American phylogenetic lineage for AIV PB2, PB1, PA, M and NS genes, and suggest that the evolutionary pathways of HA and NA genes involve exchanges between the Northern and Southern hemispheres.
Alvarez
Paula
P
Centro de Virología Animal, Instituto de Ciencia y Tecnología Dr. César Milstein, CONICET, Saladillo 2468, (1440) Buenos Aires, Argentina.
Mattiello
Rosana
R
Rivailler
Pierre
P
Pereda
Ariel
A
Davis
Charles T
CT
Boado
Lorena
L
D'Ambrosio
Elisa
E
Aguirre
Sebastian
S
Espinosa
Cora
C
La Torre
José
J
Donis
Ruben
R
Mattion
Nora
N
D000818:Animals; D001118:Argentina; D001483:Base Sequence; D001717:Birds / Q000821:virology*; D006385:Hemagglutination Inhibition Tests; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification / Q000302:isolation & purification*; D005585:Influenza in Birds / Q000175:diagnosis / Q000473:pathology; D008969:Molecular Sequence Data; D009439:Neuraminidase / Q000235:genetics; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction
D019267:Hemagglutinin Glycoproteins, Influenza Virus; D009439:Neuraminidase