Evidence for persistence of and antiviral resistance and reassortment events in seasonal influenza virus strains circulating in Cambodia.
The analysis of A/H1N1 and A/H3N2 influenza viruses collected between 2005 and 2008 in Cambodia detected strains resistant to oseltamivir and confirmed widespread resistance to adamantanes. Phylogenetic analyses revealed intrasubtype reassortment, probable reemergence of A/H3N2 viruses in two consecutive seasons, and cocirculation of different lineages in each subtype.
Fourment
Mathieu
M
Institut Pasteur in Cambodia, Virology Unit, 5, Monivong Boulevard, P.O. Box 983, Phnom Penh, Cambodia.
Mardy
Sek
S
Channa
Mey
M
Buchy
Philippe
P
D000998:Antiviral Agents / Q000494:pharmacology*; D002160:Cambodia / Q000453:epidemiology; D016000:Cluster Analysis; D024882:Drug Resistance, Viral; D005838:Genotype; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D053122:Influenza A Virus, H3N2 Subtype / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D007251:Influenza, Human / Q000453:epidemiology / Q000821:virology*; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D016865:Reassortant Viruses / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
D000998:Antiviral Agents; D012367:RNA, Viral