Urgent termination of pregnancy in pre-eclampsia and panel of antiphospholipid antibodies.
OBJECTIVE
The present work was undertaken to investigate the occurence of autoantibodies to eight various phospholipids in time of urgent termination of the pregnancy (sectio caesarea) in patients in reproductive age with severe preeclamptic symptoms.


METHODS
Autoantibodies against annexin V, ph-serine, ph-ethanolamine, ph-inositol, ph-DL-glycerol, cardiolipin, beta2-glycoprotein I (beta2-GPI), and phosphatidic acid were studied by ELISA methods.


RESULTS
Increased levels of IgA-beta2-glycoprotein I, IgG-beta2-glycoprotein I, IgG- anti-ph-serine, and IgG-anticardiolipin were found in sera of preeclamptic women in the time of urgent sectio caesarea when compared to the control group with physiological pregnancy.


CONCLUSIONS
Supposed increase in various antiphospholipid antibodies (aPLs) levels due to the stress during the short time of admission and a need for a quick medical decision to terminate the pregnancy was not unambiguously proven, but our results are evidently influenced by the current urgent life-saving treatment.
Hradecky
Libor
L
Department of Gynecology and Obstetrics, Charles University and Faculty Hospital, Pilsen, Czech Republic.
Subrt
Ivan
I
Ulcova-Gallova
Zdenka
Z
D000032:Abortion, Therapeutic; D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D010768:Phosphoserine / Q000276:immunology*; D021041:Placental Circulation / Q000276:immunology; D011225:Pre-Eclampsia / Q000097:blood / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D011247:Pregnancy; D013927:Thrombosis; D053482:beta 2-Glycoprotein I / Q000276:immunology*
D017152:Antibodies, Antiphospholipid; D053482:beta 2-Glycoprotein I; D010768:Phosphoserine