title: Direct measurement of wall stiffness for carotid arteries by ultrasound strain imaging.
abstract: OBJECTIVE
  The elastic properties of the carotid arterial wall have not been directly characterized in the clinical setting. Strain rate (SR) imaging is a newly developed echocardiographic method developed for imaging the tissue motion of the myocardium. The purpose of this study was to directly estimate the elastic properties of the carotid artery by using SR imaging in patients with coronary artery disease (CAD).
  
  
  METHODS
  A total of 135 patients with CAD, 15 age-matched controls, and 35 young healthy subjects had a carotid ultrasound examination for measuring the values of SR and strain of the carotid artery. The intima-media thickness and distensibility coefficient of the carotid artery were estimated.
  
  
  RESULTS
  Age and Framingham risk score were significantly related to SR and strain, respectively (r = 0.62-0.67, all P < .001). These strain measurements were significantly correlated with distensibility coefficient and intima-media thickness, respectively (r = 0.30-0.56, all P < .001). Similar values of the areas under the receiver operating characteristic curves were obtained among Framingham risk score (0.70 +/- 0.05), SR (0.67 +/- 0.05), and strain (0.73 +/- 0.05).
  
  
  CONCLUSIONS
  This study demonstrated that the elastic properties of the carotid artery wall were directly characterized by using SR imaging in patients with CAD.
authors.affiliation: Department of Medicine, Cardiovascular Division, Osaka Ekisaikai Hospital, Nishi-ku, Osaka, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kawasaki
authors.forename: Shota
authors.initials: S
authors.lastname: Fukuda
authors.forename: Kenei
authors.initials: K
authors.lastname: Shimada
authors.forename: Kumiko
authors.initials: K
authors.lastname: Maeda
authors.forename: Ken
authors.initials: K
authors.lastname: Yoshida
authors.forename: Hiroe
authors.initials: H
authors.lastname: Sunada
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Inanami
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Tanaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Jissho
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Taguchi
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshiyama
authors.forename: Junichi
authors.initials: J
authors.lastname: Yoshikawa
mesh_terms: D000368:Aged; D002339:Carotid Arteries / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002340:Carotid Artery Diseases / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity