title: The anti-hyperglycemic effect of plants in genus Gynura Cass.
abstract: Gynura divaricata (L.) DC and G. bicolor DC are used as secret recipes to treat diabetes mellitus in some parts of China. Pharmacological tests were performed to prove the anti-hyperglycemic effect of these two plants of genus Gynura Cass. in this study. Both water and 95% ethanol extracts of fresh G. divaricata had significant effects on lowering blood glucose level in normal mice, in which the dose of 0.4 g (crude drug)/kg of 95% ethanol extract was more effective than 50 mg/kg glyburide. The ethyl acetate and n-butanol extracts of dried G. divaricata had significant effects on lowering blood glucose level in normal and alloxan diabetic mice too. Both ethyl acetate and n-butanol extracts of dried G. bicolor showed very significant effect on lowering blood glucose level to normal and alloxan-diabetic mice, and the dose 4.0 g (crude drug)/kg had a more hypoglycemic effect than 50 mg/kg glyburide in normal mice.
authors.affiliation: Institute of Botany, Jiangsu Province, Nanjing, Jiangsu, China. lwlcnbg@mail.cnbg.net
authors.forename: Wei-Lin
authors.initials: WL
authors.lastname: Li
authors.forename: Bing-Ru
authors.initials: BR
authors.lastname: Ren
authors.lastname: Min-Zhuo
authors.forename: Yong
authors.initials: Y
authors.lastname: Hu
authors.forename: Chang-Gen
authors.initials: CG
authors.lastname: Lu
authors.forename: Ju-Lan
authors.initials: JL
authors.lastname: Wu
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.forename: Shi
authors.initials: S
authors.lastname: Sun
mesh_terms: D020001:1-Butanol / Q000737:chemistry; D000085:Acetates / Q000737:chemistry; D000496:Alloxan; D000818:Animals; D019659:Asteraceae / Q000737:chemistry* / Q000145:classification; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry; D005260:Female; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013045:Species Specificity; D014867:Water / Q000737:chemistry
chemical_list: D000085:Acetates; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D014867:Water; D000431:Ethanol; D000496:Alloxan; C007650:ethyl acetate; D020001:1-Butanol; D005905:Glyburide