Effect of cell therapy on recovery of cognitive functions in rats during the delayed period after brain injury.
We studied the effect of systemic transplantation of human stem cells from various tissues on cognitive functions of the brain in rats during the delayed period after experimental brain injury. Stem cells were shown to increase the efficacy of medical treatment with metabolic and symptomatic drugs for recovery of cognitive functions. They accelerated the formation of the conditioned defense response. Fetal neural stem cells had a stronger effect on some parameters of cognitive function 2 months after brain injury. The efficacy of bone marrow mesenchymal stem cells from adult humans or fetuses was higher 3 months after brain injury.
Roshal
L M
LM
Research Institute of Emergency Pediatric Surgery and Traumatology, Department of Public Health Services, Moscow, Russia.
Tzyb
A F
AF
Pavlova
L N
LN
Soushkevitch
G N
GN
Semenova
J B
JB
Javoronkov
L P
LP
Kolganova
O I
OI
Konoplyannikov
A G
AG
Shevchuk
A S
AS
Yujakov
V V
VV
Karaseva
O V
OV
Ivanova
T F
TF
Chernyshova
T A
TA
Konoplyannikova
O A
OA
Bandurko
L N
LN
Marey
M V
MV
Sukhikh
G T
GT
D000818:Animals; D001930:Brain Injuries / Q000523:psychology*; D017690:Cell Transplantation; D003071:Cognition; D008297:Male; D051381:Rats; D017208:Rats, Wistar