Cholesterol secosterol adduction inhibits the misfolding of a mutant prion protein fragment that induces neurodegeneration.
Scheinost
Johanna C
JC
The Scripps-Oxford Laboratory, Department of Biochemistry, University of Oxford, South Parks Rd., Oxford OX13QU, UK.
Witter
Daniel P
DP
Boldt
Grant E
GE
Offer
John
J
Wentworth
Paul
P
D000447:Aldehydes / Q000494:pharmacology; D000818:Animals; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000494:pharmacology; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D050505:Mutant Proteins / Q000494:pharmacology*; D019636:Neurodegenerative Diseases / Q000209:etiology*; D010446:Peptide Fragments / Q000235:genetics / Q000494:pharmacology*; D011328:Prions / Q000235:genetics / Q000494:pharmacology*; D011487:Protein Conformation; D017510:Protein Folding / Q000187:drug effects*; D055503:Protein Multimerization
D000447:Aldehydes; D050505:Mutant Proteins; D010446:Peptide Fragments; D011328:Prions; C512175:atheronal-B; D002784:Cholesterol