title: VEGF: a surrogate marker for peripheral vascular disease.
abstract: This study aims to evaluate the value of VEGF as a surrogate marker for peripheral vascular disease (PVD). Prior to treatment, serum VEGF levels were evaluated by enzyme-linked immunosorbent assay (ELISA) in 293 PVD patients. Risk factors and clinical parameters of PVD were documented. Twenty-six age-matched healthy volunteers served as controls. Serum VEGF values strongly correlated with Fontaine stages (p<0.006, stage IV vs. controls). High VEGF values prior to treatment were associated with poor outcome. Serum VEGF appears to indicate the severity of PVD and might serve as a surrogate indicator of disease severity.
authors.affiliation: Vascular and Endovascular Surgery, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Stehr
authors.forename: I
authors.initials: I
authors.lastname: Töpel
authors.forename: S
authors.initials: S
authors.lastname: Müller
authors.forename: K
authors.initials: K
authors.lastname: Unverdorben
authors.forename: E K
authors.initials: EK
authors.lastname: Geissler
authors.forename: P M
authors.initials: PM
authors.lastname: Kasprzak
authors.forename: H J
authors.initials: HJ
authors.lastname: Schlitt
authors.forename: M
authors.initials: M
authors.lastname: Steinbauer
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D016491:Peripheral Vascular Diseases / Q000097:blood*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012720:Severity of Illness Index; D015854:Up-Regulation; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D015415:Biomarkers; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A