title: Management and outcomes in digestive cancer surgery: design and initial results of a multicenter cohort study.
abstract: BACKGROUND
  most studies that analyze the influence of structure factors on clinical outcomes are retrospective, based on clinical-administrative databases, and mainly focusing on surgical volume.
  
  
  OBJECTIVE
  to study variations in the process and outcomes of oncologic surgery for esophagus, stomach, pancreas, liver metastases and rectum cancers in Catalonia, as well as the factors associated with these variations.
  
  
  METHODS
  a retrospective (2002) and prospective (2003-05) multicenter cohort study. Data forms were designed to collect patient, process, and care outcome characteristics before surgery, at hospital discharge, and at 3 and 6 months after discharge. Main outcome measures were hospital and follow-up mortality, complications, re-interventions, and relapse rates.
  
  
  RESULTS
  49 hospitals (80%) participated in the retrospective phase, 44 of which (90%) also participated in the prospective phase: 3,038 patients (98%) were included. No differences were observed in the profile of operated patients according to hospital level of complexity, but clinical-pathological staging and other functional status variables could not be assessed because of over 20% of missing values. There was significant variability in the volume of interventions as well as in certain aspects of the healthcare process depending on type of cancer and center complexity. High rates of esophageal cancer mortality (18.2% at discharge, 27.3% at 6 months) and of complications and re-interventions for all cancers assessed, especially rectal cancer (18.4% re-interventions at 6 months), were identified.
  
  
  CONCLUSIONS
  the study of the variability identified will require adequate risk-adjustment and should take into account different structure factors. It is necessary that information included in medical records be improved.
authors.affiliation: Catalan Agency for Health Technology Assessment and Research, Carrer de Roc Boronat 81-95, Barcelona, Spain. mespallargues@aatrm.catsalut.net
authors.forename: M
authors.initials: M
authors.lastname: Espallargues
authors.forename: C
authors.initials: C
authors.lastname: Almazán
authors.forename: C
authors.initials: C
authors.lastname: Tebé
authors.forename: R
authors.initials: R
authors.lastname: Pla
authors.forename: J M V
authors.initials: JM
authors.lastname: Pons
authors.forename: E
authors.initials: E
authors.lastname: Sánchez
authors.forename: M
authors.initials: M
authors.lastname: Mias
authors.forename: S
authors.initials: S
authors.lastname: Alomar
authors.forename: J M
authors.initials: JM
authors.lastname: Borrás
mesh_terms: D000368:Aged; D015331:Cohort Studies; D004067:Digestive System Neoplasms / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome