Targeting wall techoic acid biosynthesis: an in vivo based high-throughput screen for small molecule inhibitors.
Identification of uncommon targets for inhibition, such as virulence factors, represents an emerging approach for combating the problem of antibiotic resistance among bacteria. Unfortunately, the lack of effective systems for the discovery and evaluation of inhibitors for such targets has considerably slowed progress. A recent article in ACS Chemical Biology, however, details the development of an in vivo based high-throughput screening strategy for identification of small molecule inhibitors of wall techoic acid biosynthesis.
Chen
Wenlan
W
Departments of Biochemistry and Chemistry, The Ohio State University, Columbus, Ohio 43210, USA.
Woodward
Robert
R
Wang
Peng George
PG
D004353:Drug Evaluation, Preclinical; D057166:High-Throughput Screening Assays; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism*; D013682:Teichoic Acids / Q000096:biosynthesis*
D054852:Small Molecule Libraries; D013682:Teichoic Acids