title: [The roles for basophils in allergy].
abstract: Basophils are the least common granulocytes, and account for less than 1% of peripheral blood leukocytes. Because of this minority status and their phenotypic similarity to mast cells, basophils have often been neglected in immunological studies or considered to have minor, redundant roles in immune responses in vivo. We have recently demonstrated that basophils play critical roles in IgG-mediated systemic anaphylaxis and IgE-mediated chronic allergic inflammation. Basophils also promote the Th2 differentiation and enhance the humoral memory response. Thus, basophils are a key player in both immune regulation and allergic responses. Basophils and their products seem to be promising therapeutic targets for allergic disorders.
authors.affiliation: Department of Immune Regulation, Tokyo Medical and Dental University Graduate School.
authors.forename: Kaori
authors.initials: K
authors.lastname: Mukai
authors.forename: Kazushige
authors.initials: K
authors.lastname: Obata
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Tsujimura
authors.forename: Hajime
authors.initials: H
authors.lastname: Karasuyama
mesh_terms: D000707:Anaphylaxis / Q000503:physiopathology; D001491:Basophils / Q000502:physiology*; D002908:Chronic Disease; D006801:Humans; D006967:Hypersensitivity / Q000503:physiopathology*