[Role of reactive oxygen species in regulation of spermatogenesis and fertilization in mammals].
Modern ideas about biologic value of active oxygen forms in the processes of spermatozoon forming, maturation, preservation and mobility are considerated in the review. Spermatozoons' ability to produce free radicals is shown. They play significant role in signal transduction in the processes of: tyrosine phosphorilation of p 81 and p 105 proteins in spermatozoons through cAMP/PKA signal path; protein kinase and membrane phosphatase, cAMP activation which promote hyperactivation and capacitation of sperm, their acrosome reaction, oocyte entry and also influence of different biologically active substances on the processes. It is taken into consideration the role of different changes of the balance of prooxidative-antioxidative homeostasis in decreasing the biologic value of sperm cells: disturbance of formation processes, to fertilization ability, DNA integrity--one of the reasons for death of zygotes, embryos and malformities in the progeny.
Shostia
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D000818:Animals; D005306:Fertilization; D006706:Homeostasis; D006801:Humans; D008297:Male; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013091:Spermatogenesis; D013094:Spermatozoa / Q000201:enzymology / Q000378:metabolism* / Q000502:physiology
D017382:Reactive Oxygen Species