Peptide regulation of aging: 35-year research experience.
The authors sum up the results of many-year studies of mechanisms of aging and efficiency of peptide bioregulators in the prevention of age-specific diseases. Data on the effects of peptides, evaluated by the up-to-date methods, are presented. A molecular model of complementary interactions between short peptides and gene promotor sites, underlying the initiation of protein synthesis, is proposed. Prospects of peptide bioregulators in prevention of early aging are discussed.
Khavinson
V Kh
VKh
St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia.
Anisimov
V N
VN
D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D010455:Peptides / Q000502:physiology*; D051381:Rats
D010455:Peptides