The antiarrhythmic effects of ranolazine.
The genesis of cardiac arrhythmia can be grouped into 3 common mechanisms: abnormal automaticity, triggered activity, and re-entry. Alteration of automaticity, triggered activity, conduction, and/or refractoriness of myocardial tissue by drugs will perturb and often prevent the occurrence of arrhythmias. Ranolazine is a novel agent approved in the United States for antianginal therapy. The potential of ranolazine as an antiarrhythmic drug stems from observation of its ability to modify multiple ionic currents in cardiac cells responsible for generation of the action potential. In contrast to currently available antiarrhythmic drugs, ranolazine is well tolerated and has few side effects. Small clinical trials suggest that ranolazine may have a role in the treatment of patients with non-ST-elevation acute coronary syndrome, atrial fibrillation, long QT syndromes, and sinus node dysfunction.
Foster
Nathan J
NJ
Department of Cardiovascular Medicine, William Beaumont Hospital-Oakland University School of Medicine, Rochester, MI, USA.
Haines
David E
DE
D000083:Acetanilides / Q000009:adverse effects / Q000627:therapeutic use*; D054058:Acute Coronary Syndrome / Q000188:drug therapy; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000503:physiopathology; D001281:Atrial Fibrillation / Q000188:drug therapy; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008133:Long QT Syndrome / Q000188:drug therapy; D010879:Piperazines / Q000009:adverse effects / Q000627:therapeutic use*; D026902:Potassium Channel Blockers / Q000627:therapeutic use; D000069458:Ranolazine; D012804:Sick Sinus Syndrome / Q000188:drug therapy; D026941:Sodium Channel Blockers / Q000627:therapeutic use; D016896:Treatment Outcome
D000083:Acetanilides; D000889:Anti-Arrhythmia Agents; D010879:Piperazines; D026902:Potassium Channel Blockers; D026941:Sodium Channel Blockers; D000069458:Ranolazine