title: Inflammatory myofibroblastic tumor of the conjunctiva: response to chemotherapy with low-dose methotrexate and vinorelbine.
abstract: Inflammatory myofibroblastic tumor (IMT) is an unusual entity that mainly affects children and young adults, and for which standardized therapies for inoperable cases are still lacking. We report on a 12-year-old patient with an extremely rare and inoperable conjunctival location that was treated with chemotherapy using low-dose methotrexate plus vinorelbine, achieving complete tumor remission. This regimen is usually well tolerated and may be considered as the treatment of choice for cases of unresectable advanced IMT.
authors.affiliation: Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Favini
authors.forename: Antonio Giordano
authors.initials: AG
authors.lastname: Resti
authors.forename: Paola
authors.initials: P
authors.lastname: Collini
authors.forename: Michela
authors.initials: M
authors.lastname: Casanova
authors.forename: Cristina
authors.initials: C
authors.lastname: Meazza
authors.forename: Giovanna
authors.initials: G
authors.lastname: Trecate
authors.forename: Andrea
authors.initials: A
authors.lastname: Ferrari
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002648:Child; D003230:Conjunctival Neoplasms / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D009379:Neoplasms, Muscle Tissue / Q000188:drug therapy*; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077235:Vinorelbine
chemical_list: D014747:Vinblastine; D000077235:Vinorelbine; D008727:Methotrexate