title: Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands.
abstract: The evaluation of a series of piperazinyl carbamates and ureas, designed on the basis of previously reported TRPV1 antagonists and FAAH inhibitors, led to the identification of some 'dual-action' compounds targeting both FAAH and TRPV1 or TRPA1 receptors.
authors.affiliation: Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, 00185 Roma, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Morera
authors.forename: Luciano
authors.initials: L
authors.lastname: De Petrocellis
authors.forename: Ludovica
authors.initials: L
authors.lastname: Morera
authors.forename: Aniello Schiano
authors.initials: AS
authors.lastname: Moriello
authors.forename: Alessia
authors.initials: A
authors.lastname: Ligresti
authors.forename: Marianna
authors.initials: M
authors.lastname: Nalli
authors.forename: David F
authors.initials: DF
authors.lastname: Woodward
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Di Marzo
authors.forename: Giorgio
authors.initials: G
authors.lastname: Ortar
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D008024:Ligands; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D050051:Transient Receptor Potential Channels / Q000037:antagonists & inhibitors*; D014508:Urea / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000099252:Fatty Acid Amide Hydrolases
chemical_list: D000581:Amidohydrolases; D002219:Carbamates; D008024:Ligands; D050051:Transient Receptor Potential Channels; D014508:Urea; D000099252:Fatty Acid Amide Hydrolases