CD57+ T lymphocytes and functional immune deficiency.
CD57(+) expression in T lymphocytes has been recognized for decades as a marker of in vitro replicative senescence. In recent years, accumulating evidences have pointed on the utility of this marker to measure functional immune deficiency in patients with autoimmune disease, infectious diseases, and cancers. We review here the relevant literature and implications in clinical settings.
Focosi
Daniele
D
Division of Hematology, Azienda Ospedaliera Santa Chiara, University of Pisa, via Roma, Pisa, Italy. dfocosi@tin.it
Bestagno
Marco
M
Burrone
Oscar
O
Petrini
Mario
M
D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D015415:Biomarkers; D018959:CD57 Antigens / Q000032:analysis*; D018414:CD8-Positive T-Lymphocytes / Q000737:chemistry / Q000276:immunology* / Q000473:pathology; D016922:Cellular Senescence / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007239:Infections / Q000276:immunology* / Q000473:pathology; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000737:chemistry / Q000276:immunology* / Q000473:pathology; D014181:Transplantation Immunology; D014777:Virus Diseases / Q000276:immunology / Q000473:pathology
D015415:Biomarkers; D018959:CD57 Antigens