Genetic variation in CYP27B1 is associated with congestive heart failure in patients with hypertension.
OBJECTIVE
We tested the hypothesis that genetic variation in vitamin D-dependent signaling is associated with congestive heart failure in human subjects with hypertension.


METHODS
Functional polymorphisms were selected from five candidate genes: CYP27B1, CYP24A1, VDR, REN and ACE. Using the Marshfield Clinic Personalized Medicine Research Project, we genotyped 205 subjects with hypertension and congestive heart failure, 206 subjects with hypertension alone and 206 controls (frequency matched by age and gender).


RESULTS
In the context of hypertension, a SNP in CYP27B1 was associated with congestive heart failure (odds ratio: 2.14 for subjects homozygous for the C allele; 95% CI: 1.05-4.39).


CONCLUSIONS
Genetic variation in vitamin D biosynthesis is associated with increased risk of heart failure.
Wilke
Russell A
RA
Medical College of Wisconsin, WI, USA.
Simpson
Robert U
RU
Mukesh
Bickol N
BN
Bhupathi
Satya V
SV
Dart
Richard A
RA
Ghebranious
Nader R
NR
McCarty
Catherine A
CA
D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase / Q000235:genetics*; D000328:Adult; D000368:Aged; D005260:Female; D014644:Genetic Variation; D006333:Heart Failure / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014807:Vitamin D / Q000378:metabolism
D014807:Vitamin D; D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase