Association between the RAGE G82S polymorphism and Alzheimer's disease.
The receptor for advanced glycation end products (RAGE) is associated with several pathological states including Alzheimer's disease (AD) pathology, while its soluble form (sRAGE) acts as a decoy receptor. We have tested for association of AD with a functional single-nucleotide polymorphism (SNP) in the RAGE gene (G82S; rs2070600), a SNP associated with increased ligand affinity of RAGE. Analysis of a Chinese cohort (276 cases; 254 controls) showed a higher prevalence of the RAGE 82S allele and GS + SS genotype in the patients [82S vs. 82G: P = 0.017, odds ratio (OR) = 1.431; GS + SS vs. GG: P = 0.025, OR = 1.490]. Further stratification analysis revealed that the association of the RAGE G82S polymorphism with AD was significant in early onset AD stratum. Moreover, plasma sRAGE levels were lower in AD than in normal elderly controls, and the presence of the risk allele was associated with further plasma sRAGE reduction and a fast cognitive deterioration. The present study provides preliminary evidence that the RAGE G82S variant is involved in genetic susceptibility to AD.
Li
Keshen
K
Department of Neurology, Affiliated Hospital of Guangdong Medical College, 524001, Zhanjiang, China.
Dai
Dawei
D
Zhao
Bin
B
Yao
Lifen
L
Yao
Songpo
S
Wang
Binyou
B
Yang
Ze
Z
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002681:China; D003072:Cognition Disorders / Q000097:blood / Q000235:genetics; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D000067759:Receptor for Advanced Glycation End Products / Q000097:blood / Q000235:genetics*
D000067759:Receptor for Advanced Glycation End Products