Cutaneous hyalohyphomycosis by Scedosporium apiospermum in an immunocompromised patient.
Scedosporium apiospermum is a ubiquitous filamentous fungus that may infect immunocompetent patients after trauma and may cause severe and often fatal infections in immunocompromised hosts. Here, we present the case of a 28-year-old female with S. apiospermum infection on the left forearm that had developed while she was on long-term immunosuppressant therapy. Analysis of a skin biopsy specimen showed a mixed cell granuloma with hyaline septate hyphae. Culture of the abscess revealed S. apiospermum which was identified as S. apiospermum sensu stricto by sequencing of the internal transcribed spacer-1 region of ribosomal DNA genes. Resection of the eruption and oral itraconazole (100 mg day(-1)) therapy for 4 months was effective in curing the infection.
Makino
Koji
K
Fukushima
Satoshi
S
Maruo
Keishi
K
Egawa
Kiyofumi
K
Nishimoto
Katsutaro
K
Ihn
Hironobu
H
D000284:Administration, Oral; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage; D001706:Biopsy; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D003646:Debridement; D003881:Dermatomycoses / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology* / Q000628:therapy; D005260:Female; D005542:Forearm / Q000473:pathology; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D017964:Itraconazole / Q000008:administration & dosage; D021681:Scedosporium / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA; D012867:Skin / Q000473:pathology
D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D007166:Immunosuppressive Agents; D017964:Itraconazole