title: The neural basis of auditory temporal discrimination in girls with fragile X syndrome.
abstract: Fragile X syndrome (FXS) is a common genetic disorder in which temporal processing may be impaired. To our knowledge however, no studies have examined the neural basis of temporal discrimination in individuals with FXS using functional magnetic resonance imaging (fMRI). Ten girls with fragile X syndrome and ten developmental age-matched typically developing controls performed an auditory temporal discrimination task in a 3T scanner. Girls with FXS showed significantly greater brain activation in a left-lateralized network, comprising left medial frontal gyrus, left superior and middle temporal gyrus, left cerebellum, and left brainstem (pons), when compared to a developmental age-matched typically developing group of subjects who had similar in-scanner task performance. There were no regions that showed significantly greater brain activation in the control group compared to individuals with FXS. These data indicate that networks of brain regions involved in auditory temporal processing may be dysfunctional in FXS. In particular, it is possible that girls with FXS employ left hemispheric resources to overcompensate for relative right hemispheric dysfunction.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, 401 Quarry Road, Stanford, CA 94305-5795, USA.
authors.forename: Scott S
authors.initials: SS
authors.lastname: Hall
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Walter
authors.forename: Elena
authors.initials: E
authors.lastname: Sherman
authors.forename: Fumiko
authors.initials: F
authors.lastname: Hoeft
authors.forename: Allan L
authors.initials: AL
authors.lastname: Reiss