title: Aggressive undifferentiated colon carcinoma producing granulocyte-colony stimulating factor: report of a case.
abstract: We report a rare case of granulocyte-colony stimulating factor (G-CSF)-producing undifferentiated carcinoma of the ascending colon. A 52-year-old Japanese man presented with a rapidly growing, aggressive abdominal tumor, and severe leukocytosis (63 000/mm(3)). The serum level of G-CSF was remarkably elevated to 640 pg/ml (normal, <18.1 pg/ml). The patient underwent palliative cytoreductive surgery for ascending colon carcinoma with lymph node and liver metastases. Histological examination revealed an undifferentiated carcinoma of the ascending colon. The tumor cells were positive for G-CSF on immunohistochemical staining. The leukocyte counts and G-CSF level decreased after surgery. Thus, we diagnosed G-CSF-producing colon carcinoma. His general condition deteriorated rapidly and he died of residual tumor growth on postoperative day 24.
authors.affiliation: Department of Surgery, Nippon Medical School Tama-Nagayama Hospital, Tama, Tokyo 206-8512, Japan.
authors.forename: Akihisa
authors.initials: A
authors.lastname: Matsuda
authors.forename: Koji
authors.initials: K
authors.lastname: Sasajima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsutani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maruyama
authors.forename: Masayuki
authors.initials: M
authors.lastname: Miyamoto
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Seiji
authors.initials: S
authors.lastname: Suzuki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Suzuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Tajiri
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D003082:Colectomy / Q000379:methods; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D003113:Colonoscopy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005500:Follow-Up Studies; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor; D016179:Granulocyte Colony-Stimulating Factor