SAPHO syndrome: is a range of pathogen-associated rheumatic diseases extended?
SAPHO syndrome, representing a constellation of synovitis, acne, palmo-plantar pustulosis, hyperostosis, and osteitis, is now recognized as a distinct medical entity: a reactive infectious osteitis. Genetic, immunological, and bacterial mechanisms are implicated in the development of the disease. Diagnostic problems may arise due to non-complete manifestations of SAPHO: either acne and arthritis or acne and anterior wall osteitis with an unclear pustulosis history. The interventional study of Assmann et al. is a significant addition to a long range of publications showing an association of SAPHO with Propionibacterium acnes. Randomized control studies are needed to confirm the effects of antibiotic therapy.
Rozin
Alexander P
AP
D020083:Acquired Hyperostosis Syndrome / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use; D006801:Humans; D011425:Propionibacterium acnes / Q000276:immunology
D000900:Anti-Bacterial Agents; D018501:Antirheumatic Agents