title: Changes in muscular lipids in unilateral isolated hypertrophy of gastrocnemius muscle can be revealed by 1H MR spectroscopy.
abstract: OBJECTIVE
  To test whether proton magnetic resonance spectroscopy ((1)H-MRS) reveals changes in the lipid content of the gastrocnemius muscle (GM) and soleus muscle (SOL) of a patient with unilateral isolated hypertrophy of the right GM.
  
  
  METHODS
  (1)H-MRS was performed on a 1.5 Tesla (T) whole-body unit. Muscular lipids inside SOL and GM were assessed in both calves of the patient by a STEAM (stimulated echo acquisition mode) localization sequence. Results were compared to a control group of four healthy volunteers.
  
  
  RESULTS
  Total amount of muscular lipids in the hypertrophic GM of the patient was clearly increased compared to the controls (38.7 versus 21.8+/-3.5 a.u.) while intramyocellular lipids of the adjacent SOL were lower compared to the contralateral healthy leg.
  
  
  CONCLUSIONS
  Muscular lipids are substrates for metabolism and can be assessed non-invasively by (1)H-MRS. (1)H-MRS is considered to be a helpful tool in clinical assessment of muscle metabolism in cases with muscular hypo- or hypertrophy.
authors.affiliation: Section on Experimental Radiology, Department of Diagnostic Radiology, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076 Tuebingen, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Brechtel
authors.forename: Juergen
authors.initials: J
authors.lastname: Machann
authors.forename: Margarete
authors.initials: M
authors.lastname: Pick
authors.forename: Juergen F
authors.initials: JF
authors.lastname: Schaefer
authors.forename: Claus D
authors.initials: CD
authors.lastname: Claussen
authors.forename: Fritz
authors.initials: F
authors.lastname: Schick
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000378:metabolism; D007866:Leg / Q000473:pathology; D050356:Lipid Metabolism; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000473:pathology