[The use of cereton in the rehabilitation of patients with hemorrhagic stroke].
Forty patients were included in the study: 20 patients of main group received cereton in dosage 1000 mg intramuscular during 15 days and 20 patients of control group received placebo. Patient's state was assessed with MMSE, Hodkinson test, "learning of 10 words", Spielberg's trait-state anxiety inventory (a modification of Khanin), Beck depression scale. Brain blood supply was analyzed with rheoencephalography, balance in the vertical position--with stabilometry. The rehabilitation of disturbed cognitive functions measured with MMSE and "learning of 10 words" test was significantly better in the main group of patients (p < 0.05). Reoencephalographic data showed the significant increase of blood supply, mainly in the left brain hemisphere, compared with baseline values (p = 0.05) as well as with the control group (p = 0.03). There was a trend towards the higher rate of blood supply that reflected the decrease of baseline tonus of resistance arteries in both hemispheres, predominantly in the left side, with the positive dynamics as compared to the same values in the controls (p < 0.041). The results of stabilometric study revealed a trend toward the decrease of initially increased deviations of center of pressure on both axes, mostly in the frontal plane, in the main group (p < 0.001). Almost all patients reported a good tolerability of the drug. In conclusion, the course treatment with cereton in the late rehabilitation and residual periods of hemorrhagic stroke leads to the significant improvement of cognitive functions and brain blood supply, in particular brain hemispheric regions, due to the decrease of baseline tonus of resistance arteries and promotes the improvement of balance function.
Buĭlova
T V
TV
Glotova
M E
ME
Khalak
M E
ME
Vashkevich
V V
VV
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000534:rehabilitation; D003071:Cognition / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005260:Female; D005997:Glycerylphosphorylcholine / Q000008:administration & dosage*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D004856:Postural Balance / Q000502:physiology; D020127:Recovery of Function; D020521:Stroke / Q000209:etiology / Q000503:physiopathology; D000071939:Stroke Rehabilitation; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
D005997:Glycerylphosphorylcholine