Double-stranded polynucleotides as interferon inducers.
A discussion of factors considered influential in making a polynucleotide an efficient inducer of interferon was presented. These factors were double-strandedness of the polynucleotides, the sugar moiety of the polynucleotides, thermal stability, resistance to enzymatic degradation, and molecular size of the polynucloetides. Recent developments concerning interferon induction during virus infection were also discussed.
Field
A K
AK
Division of Virus and Cell Biology Research, Merck Institute for Therapeutic Research, West Point, Pennsylvania 19486.
Tytell
A A
AA
Lampson
G P
GP
Nemes
M M
MM
Hilleman
M R
MR