The metabolic syndrome of omega3-depleted rats. V. Intestinal phospholipid omega6 fatty acids.
This study aims mainly at investigating the effects of a dietary deprivation and replenishment of omega3 PUFA upon the phospholipid pattern of omega6 PUFA in the duodenum, jejunum, caecum and colon of rats exposed for 3-7 months to an omega3-depleted diet and then eventually exposed for 2-4 weeks to an omega3-rich diet. In control rats, the relative weight content of all omega6 fatty acids differed in the proximal and distal intestinal segments. In the omega3-depleted rats the C18:2omega6, C20:2omega6 and C20:3omega6 content was decreased whilst that of C20:4omega6 and C22:4omega6 was increased. Significant correlations were found in the caecum or colon between the C18:2omega6 or C20:4omega6 content of intestinal phospholipids and their C22:6omega3 content, an increase in the latter content coinciding with an increase in C18:2omega6 and decrease of C20:4omega6. Such was also the case for C20:4omega6, but not C18:2omega6, in the duodenum and jejunum. At these proximal intestinal levels, exposure of the omega3-depleted rats to a flaxseed oil-enriched diet indeed decreased the C18:2omega6 phospholipid content, an effect possibly attributable to the much lower content of C18:2omega6 in the latter diet, as distinct from the sunflower diet offered to the omega3-depleted rats during the first 7 months. However, at more distal intestinal levels, and like in the liver, a deficiency in omega3 fatty acids apparently favours the stepwise conversion of C18:2omega6 to C20:4omega6 and C22:4omega6.
Hacquebard
Mirjam
M
Laboratory of Experimental Surgery, Université Libre de Bruxelles, B-1070 Brussels, Belgium.
Portois
Laurence
L
Malaisse
Willy J
WJ
Carpentier
Yvon A
YA
D000818:Animals; D015525:Fatty Acids, Omega-3 / Q000378:metabolism*; D043371:Fatty Acids, Omega-6 / Q000378:metabolism*; D005260:Female; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000737:chemistry; D016014:Linear Models; D008043:Linseed Oil / Q000378:metabolism; D024821:Metabolic Syndrome / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats
D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D010743:Phospholipids; D008043:Linseed Oil