title: [Successful reintroduction of mesylate imatinib after pneumonitis in two patients with gastrointestinal stromal tumor (GIST)].
abstract: We report 2 cases of successful reintroduction of mesylate imatinib for gastrointestinal stromal tumor (GIST) after drug-induced pneumonitis. Both of them were women in the fifth decade who had been medicated by mesylate imatinib about for 5 months previously, and had been given a diagnosis of imatinib mesylate-induced pneumonitis. After only cessation of that drug, symptoms and shadows on chest X-ray film improved. However, we had to reintroduce the drug because of the growth of primary tumor, so we gave half the previous dose of imatinib mesylate, with low dose prednisone. There has been no recurrence of drug related pneumonitis and effective control of the primary tumor was obtained. The evidence acquired from our cases suggests that it may be possible to reintroduce imatinib mesylate carefully by adjusting the dose with low dose prednisone in a GIST patient, without causing recurrence of drug-induced pneumonitis.
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Sendai Medical Center.
authors.forename: Noriko
authors.initials: N
authors.lastname: Izumiyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Noguchi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shishikura
authors.forename: Wakana
authors.initials: W
authors.lastname: Saitou
authors.forename: Katsushi
authors.initials: K
authors.lastname: Nishimaki
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Kan
authors.initials: K
authors.lastname: Sasamori
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miki
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Tezuka
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kikuchi
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001549:Benzamides; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy*; D006801:Humans; D000068877:Imatinib Mesylate; D008875:Middle Aged; D010879:Piperazines / Q000008:administration & dosage*; D011014:Pneumonia / Q000139:chemically induced*; D011743:Pyrimidines / Q000008:administration & dosage*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate