[Nongenomic effects of glucocorticoids, an important mechanism of inhaled glucocorticoids action in asthma].
Authors describe the clinical implications of nongenomic effects of glucocorticoids, important also for the inhaled drugs. Data suggest that these rapid actions of glucocorticoids are important in the pharmacotherapy of asthma, particularly for prevention and treatment of acute exacerbations. Their influence on remodeling is also considered.
Grzanka
Alicja
A
Katedra i Oddział Kliniczny Chorób Wewnetrznych, Dermatologii i Alergologii w Zabru Slaskiego Uniwerstytetu Medycznego w Katowicach. alicjag@mp.pl
Jarzab
Jerzy
J
D000280:Administration, Inhalation; D018927:Anti-Asthmatic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D015550:Cell Degranulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy; D008407:Mast Cells / Q000187:drug effects; D009330:Nebulizers and Vaporizers
D018927:Anti-Asthmatic Agents; D005938:Glucocorticoids