title: Study of the safety of transplantation of cultured autologous human chondroblasts.
abstract: Study of tumorigenic activity of cultured human chondroblasts intended for autologous transplantations showed that subcutaneous injection of human chondroblast suspension in a dose of 10(7)cells/0.2 ml did not cause the development of tumors in C.B-17 SCID immunodeficient mice over 12 weeks. Subcutaneous formations of compact cartilaginous consistency persisted at the site of chondroblast transplantation in all animals; these formations gradually shrank. Subcutaneous injection of tumor cell suspension (A204 human embryonic sarcoma) to C.B-17 SCID mice under the same conditions caused 100% development of tumors (poorly differentiated sarcomas) by day 14.
authors.affiliation: Medical Genetic Research Center, Russian Academy of Medical Sciences, Moscow, Russia. rzhaninova@rm7.ru
authors.forename: A A
authors.initials: AA
authors.lastname: Rzhaninova
authors.forename: N P
authors.initials: NP
authors.lastname: Ermakova
authors.forename: I B
authors.initials: IB
authors.lastname: Merkulova
authors.forename: A I
authors.initials: AI
authors.lastname: Mishin
authors.forename: I V
authors.initials: IV
authors.lastname: Arutjunian
authors.forename: A V
authors.initials: AV
authors.lastname: Volkov
authors.forename: L M
authors.initials: LM
authors.lastname: Mikhailova
authors.forename: A N
authors.initials: AN
authors.lastname: Murashev
authors.forename: D V
authors.initials: DV
authors.lastname: Goldshtein
mesh_terms: D000818:Animals; D017690:Cell Transplantation; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology*; D006801:Humans; D051379:Mice; D016513:Mice, SCID