title: Obstructive sleep apnea syndrome and upper airway inflammation.
abstract: Obstructive sleep apnea syndrome (OSAS) is associated with inflammatory processes and elevated plasma cytokines. Inflammatory processes associated with OSAS may also act as potential mediators of cardiovascular morbidity in these patients. OSAS is associated with elevated levels of C reactive protein (CRP), as a marker of inflammation and cardiovascular risk. At the inflammatory point of view, the levels of TNF-alpha, IL-6, hsCRP, adhesion molecules, monocyte chemo attractant protein-1 and resist in were markedly and significantly elevated in patients with sleep apnea than those in normal control subjects. We reviewed several recent patents and literature in English about OSAS and upper airway inflammation relation since 1966 from the Medline database.
authors.affiliation: Department of ORL & Head and Neck Surgery, Ankara Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: Hasan M
authors.initials: HM
authors.lastname: Inancli
authors.forename: Murat
authors.initials: M
authors.lastname: Enoz
mesh_terms: D000402:Airway Obstruction; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007249:Inflammation; D010330:Patents as Topic; D052243:Resistin / Q000378:metabolism*; D020181:Sleep Apnea, Obstructive / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D015815:Cell Adhesion Molecules; D016207:Cytokines; D052243:Resistin; D002097:C-Reactive Protein