title: [Multiple, painful, treatment-resistant leg ulcers associated with dermatomyositis-like lesions over the interphalangeal joints induced by hydroxyurea].
abstract: The onset of a dermatomyositis-like rash and persistent skin ulcers during long-term treatment with hydroxyurea is a very rare event that has not been fully described in the literature. The fact that these lesions have a typical clinical presentation and course, and that complete resolution can only be achieved by immediate withdrawal of the drug, means that dermatologists should be aware of this condition in order to avoid a delay in diagnosis. We present the case of a 76-year-old woman who developed a dermatomyositis-like eruption associated with chronic ulcers on the lower limbs during long-term treatment with hydroxyurea.
authors.affiliation: Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España. antmarto@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Martorell-Calatayud
authors.forename: C
authors.initials: C
authors.lastname: Requena
authors.forename: E
authors.initials: E
authors.lastname: Nagore-Enguídanos
authors.forename: C
authors.initials: C
authors.lastname: Guillén-Barona
mesh_terms: D000368:Aged; D003882:Dermatomyositis / Q000139:chemically induced*; D005260:Female; D006229:Hand Dermatoses / Q000139:chemically induced*; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D007871:Leg Ulcer / Q000139:chemically induced*; D011994:Recombinant Proteins; D013920:Thrombocythemia, Essential / Q000150:complications / Q000188:drug therapy*
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D006918:Hydroxyurea