Peripheral blood CD8+DR+ T-cell count: a potential new immunologic marker of unexplained recurrent abortion.
A case-control study was performed to assess whether T-cell activation profile of CD8+ T-cells is associated with unexplained recurrent abortion. Women with abortion had significantly higher percentages (32 +/- 11 vs. 24 +/- 13%) and absolute numbers (160 +/- 78 vs. 114 +/- 83 cells/mm(3)) of CD8+DR+ T-cells than controls.
Carbone
Javier
J
Department of Immunology, Hospital General Universitario Gregorio Marañon, Madrid, Spain. jcarbone.hgugm@salud.madrid.org
Gallego
Antonio
A
Lanio
Nallibe
N
Chean
Carmen
C
Navarro
Joaquin
J
Sarmiento
Elizabeth
E
D000026:Abortion, Habitual / Q000097:blood* / Q000175:diagnosis / Q000276:immunology*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006684:HLA-DR Antigens / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000378:metabolism; D018655:Lymphocyte Count; D011247:Pregnancy; D011446:Prospective Studies
D015415:Biomarkers; D006684:HLA-DR Antigens