Effect of manganese-superoxide dismutase genetic polymorphisms IVS3-23T/G on noise susceptibility in Taiwan.
OBJECTIVE
The aim of the study is to investigate the distribution of manganese-superoxide dismutase (SOD2) genetic polymorphisms IVS3-23T/G and their influence on noise susceptibility in Asians.


METHODS
Questionnaires about history of noise exposure were administered to factory workers, and audiometric data and blood specimens were obtained during their routine annual health examinations. The SOD2 typing was extended with polymerase chain reaction and screened with single-strand conformation polymorphism. The associations of genetic polymorphisms with noise-induced hearing loss (NIHL) were analyzed.


RESULTS
The allele frequencies of T and G in the population of this study were 0.868 and 0.132, respectively. In 200 screened participants, individuals with T/G genotype were significantly more vulnerable to noise (adjusted odds ratio, 6.222; 95% confidence interval, 1.498-25.855) than the wild type (ie, T/T) by logistic regressions.


CONCLUSIONS
The distributions of SOD2 genetic polymorphisms for Asians are different from those reported on Europeans. Individuals with T/G genotype were more vulnerable to noise. This single nucleotide polymorphism is worthy of more studies for the application to NIHL monitoring.
Chang
Ning-Chia
NC
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ho
Chi-Kung
CK
Wu
Ming-Tsang
MT
Yu
Ming-Lung
ML
Ho
Kuen-Yao
KY
D000328:Adult; D000375:Aging; D044466:Asian People / Q000235:genetics*; D001299:Audiometry; D004430:Ear Protective Devices / Q000706:statistics & numerical data; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006317:Hearing Loss, Noise-Induced / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008297:Male; D009784:Occupational Diseases / Q000453:epidemiology / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational / Q000235:genetics*; D012907:Smoking; D013482:Superoxide Dismutase / Q000235:genetics*; D011795:Surveys and Questionnaires; D013624:Taiwan / Q000453:epidemiology; D000099156:Superoxide Dismutase 2
D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2