title: Declining invasive pneumococcal disease mortality in the United States, 1990-2005.
abstract: PCV7 use in the U.S. has led to notable decreases in invasive pneumococcal disease (IPD). We examined PCV7 influence on IPD mortality for all age groups using National Multiple-Cause-of-Death data (1990-2005). Age-specific mortality rates were compared before and after PCV7 use. Average decreases in age-adjusted mortality rates for meningitis and septicemia accelerated post-PCV7, the greatest decline observed in septicemia-related deaths. The youngest and oldest age groups experienced large decreases in age-specific mortality rates after the introduction of PCV7. Mortality rate decline across all age groups strengthens evidence of vaccine-induced herd immunity and provides additional information for cost-benefit analyses of PCV7.
authors.affiliation: Department of Epidemiology, School of Public Health, UCLA, Los Angeles, CA 90095, USA. marifi214@gmail.com
authors.forename: Marifi
authors.initials: M
authors.lastname: Pulido
authors.forename: Frank
authors.initials: F
authors.lastname: Sorvillo
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008581:Meningitis / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000401:mortality* / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D018805:Sepsis / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines