title: Retinal nerve fiber layer thickness and spatial and temporal contrast sensitivity in multiple sclerosis.
abstract: OBJECTIVE
  To measure peripapillary retinal nerve fiber layer (RNFL) thickness and spatial and temporal contrast sensitivity in multiple sclerosis (MS) taking into account previous history of optic neuropathy (ON).
  
  
  METHODS
  Thirty patients (60 eyes) with relapsing-remitting MS were selected (MS group). The MS ON group was composed of 31 eyes with previous history of optic neuropathy and the MS non-ON group of 29 eyes was without previous history of optic neuropathy. Thickness of the RNFL was measured with optical coherence tomography (OCT) with the Stratus OCT. As for sensitivity to spatial contrast,we used Pelli-Robson and Sloan charts. Sensitivity to temporal contrast was explored using frequency doubling technology perimetry (FDTP).
  
  
  RESULTS
  The average thickness of RNFL in the MS, MS ON, MS non-ON, and control groups were 88.2 +/= 18.9 microm, 80.81 +/- 18.4 microm, 96.7 +/- 15.8 microm, and 106 +/- 12.2 microm, respectively. The spatial contrast vision and FDTP results were less in the MS non-ON group than in the control group. The average thickness of RNFL correlated to the scores of spatial and temporal contrast vision.
  
  
  CONCLUSIONS
  MS is accompanied by visual function alteration even in the absence of acute optic neuropathy. The important correlation between functional and anatomic aspect confirms the value of OCT to appreciate the subclinical involvement of the optic nerve. Associated with tests exploring visual function, the OCT could reveal itself pertinent in evaluation of the different therapeutics used in MS ON.
authors.affiliation: Service d' Ophtalmologie, Centre Hospitalier Universitaire de Fort de France, Martinique, France. harold.merle@chu-fortdefrance.fr
authors.forename: Harold
authors.initials: H
authors.lastname: Merle
authors.forename: Stephane
authors.initials: S
authors.lastname: Olindo
authors.forename: Angelique
authors.initials: A
authors.lastname: Donnio
authors.forename: Laurence
authors.initials: L
authors.lastname: Beral
authors.forename: Raymond
authors.initials: R
authors.lastname: Richer
authors.forename: Didier
authors.initials: D
authors.lastname: Smadja
authors.forename: Philippe
authors.initials: P
authors.lastname: Cabre
mesh_terms: D000328:Adult; D015350:Contrast Sensitivity / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000503:physiopathology*; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009902:Optic Neuritis / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012607:Scotoma / Q000503:physiopathology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology