Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death.
Death-associated protein kinase (DAPK) is a stress-regulated protein kinase that mediates a range of processes, including signal-induced cell death and autophagy. Although the kinase domain of DAPK has a range of substrates that mediate its signalling, the additional protein interaction domains of DAPK are relatively ill defined. This review will summarize our current knowledge of the DAPK interactome, the use of peptide aptamers to define novel protein-protein interaction motifs, and how these new protein-protein interactions give insight into DAPK functions in diverse cellular processes, including growth factor signalling, the regulation of autophagy, and its emerging role in the regulation of immune responses.
Lin
Yao
Y
CRUK p53 Signal Transduction Laboratories, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Hupp
Ted R
TR
Stevens
Craig
C
D000595:Amino Acid Sequence; D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D001343:Autophagy / Q000502:physiology; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D064550:Death-Associated Protein Kinases; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D054730:Protein Interaction Domains and Motifs; D011494:Protein Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013379:Substrate Specificity; D058570:TOR Serine-Threonine Kinases
D051017:Apoptosis Regulatory Proteins; D006133:Growth Substances; D011494:Protein Kinases; C546842:MTOR protein, human; D064550:Death-Associated Protein Kinases; D058570:TOR Serine-Threonine Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases