Proteomic analysis of lithium-induced gene expression in the rat hypothalamus.
The hypothalamic proteomes were analyzed 1 and 6 hr after an intraperitoneal injection of lithium chloride or sodium chloride (0.15 M, 12 ml/kg). Results showed that expression of 14 and 32 proteomes was increased consistently by 1 hr and 6 hr of lithium treatment, respectively. Among them, tentative implications of glial fibrillary acidic protein, receptor-type protein tyrosine phosphatase, spectrin, and glutamate dehydrogenase in the lithium-induced activation of the hypothalamic-pituitary-adrenal axis, and conditioned taste aversion have been discussed. The proteomes listed in this study will provide, at least, a new insight to understand the molecular mechanism of lithium's action in the brain.
Lee
Joo Young
JY
Department of Pharmacology, Korea University College of Medicine, Seoul, Korea.
Lee
Jong-Ho
JH
Moon
Young Wha
YW
Chun
Boe-Gwun
BG
Jahng
Jeong Won
JW
D000818:Animals; D018692:Antimanic Agents / Q000494:pharmacology*; D030541:Databases, Genetic; D004452:Echocardiography; D015870:Gene Expression / Q000187:drug effects*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D018021:Lithium Chloride / Q000494:pharmacology*; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D011506:Proteins / Q000737:chemistry; D040901:Proteomics; D051381:Rats; D017207:Rats, Sprague-Dawley; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D018692:Antimanic Agents; D009419:Nerve Tissue Proteins; D011506:Proteins; D018021:Lithium Chloride