Synthesis and antitumor activity of novel 2',3'-dideoxy-2',3'-diethanethionucleosides bearing 1,2,3-triazole residues.
A series of novel 2',3'-dideoxy-2',3'-diethanethioribonucleosides and those modified with a triazole ring were prepared in excellent yields and their antitumor activity was evaluated. Nucleosides with a triazole ring, 16a-16c, showed significantly improved activity towards a broad range of tumor cell lines.
Yu
Jin-Lan
JL
School of Chemical Engineering & Environment, Beijing Institute of Technology, Beijing 100081, China.
Wu
Qin-Pei
QP
Zhang
Qing-Shan
QS
Liu
Yan-Hong
YH
Li
Yun-Zheng
YZ
Zhou
Zi-Ming
ZM
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013872:Thionucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014230:Triazoles / Q000737:chemistry*
D000970:Antineoplastic Agents; D013872:Thionucleosides; D014230:Triazoles