title: Titrated propofol induction vs. continuous infusion in children undergoing magnetic resonance imaging.
abstract: BACKGROUND
  Propofol is the popular intravenous (i.v.) anaesthetic for paediatric sedation because of its rapid onset and recovery. We compared the efficacy and safety of a single dose and conventional infusion of propofol for sedation in children who underwent magnetic resonance imaging (MRI).
  
  
  METHODS
  This was a double-blind, randomized-controlled study. One hundred and sixty children were assigned to group I (single dose) or II (infusion). Sedation was induced with i.v. propofol 2 mg/kg, and supplemental doses of propofol 0.5 mg/kg were administered until adequate sedation was achieved. After the induction of sedation, we treated patients with a continuous infusion of normal saline at a rate of 0.3 ml/kg/h in group I and the same volume of propofol in group II. In case of inadequate sedation, additional propofol 0.5 mg/kg was administered and the infusion rate was increased by 0.05 ml/kg/h. Induction time, sedation time, recovery time, additional sedation and adverse events were recorded.
  
  
  RESULTS
  Recovery time was significantly shorter in group I compared with group II [0 (0-3) vs. 1 (0-3), respectively, P<0.001]. Group I (single dose) had significantly more patients with recovery time 0 compared with group II (infusion) (65/80 vs. 36/80, respectively, P<0.001). Induction and sedation times were not significantly different between groups. There was no significant difference in the frequency of additional sedation and adverse events between groups.
  
  
  CONCLUSIONS
  A single dose of propofol without a continuous infusion can provide appropriate sedation in children undergoing MRI for <30 min.
authors.affiliation: Department of Anaesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: J E
authors.initials: JE
authors.lastname: Cho
authors.forename: W O
authors.initials: WO
authors.lastname: Kim
authors.forename: D J
authors.initials: DJ
authors.lastname: Chang
authors.forename: E M
authors.initials: EM
authors.lastname: Choi
authors.forename: S Y
authors.initials: SY
authors.lastname: Oh
authors.forename: H K
authors.initials: HK
authors.lastname: Kil
mesh_terms: D000762:Anesthesia Recovery Period; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002648:Child; D002675:Child, Preschool; D016292:Procedural Sedation / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000097:blood; D017060:Patient Satisfaction; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects; D015656:Respiratory Mechanics / Q000187:drug effects; D018401:Sample Size
chemical_list: D018686:Anesthetics, Intravenous; D002245:Carbon Dioxide; D010100:Oxygen; D015742:Propofol