Unexplained fetal loss: the fetal side of thrombophilia.
Carrier status of the fetus for factor V polymorphism or double homozygosity for mutant alleles of the PAI-1 4 G/4 G and MTHFR T677 T polymorphisms must be considered risk factors for intrauterine fetal death. The clinical implications of these data need to be addressed in a prospective study to confirm our preliminary data and to answer the question of whether or not double homozygous individuals should be treated with low molecular-weight heparin and/or low-dose aspirin.
Tranquilli
Andrea Luigi
AL
Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy.
Saccucci
Franca
F
Giannubilo
Stefano Raffaele
SR
Cecati
Monia
M
Nocchi
Linda
L
Lorenzi
Sara
S
Emanuelli
Monica
M
D000328:Adult; D005165:Factor V / Q000235:genetics; D005260:Female; D005313:Fetal Death / Q000175:diagnosis / Q000235:genetics*; D005315:Fetal Diseases; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000235:genetics*; D019851:Thrombophilia / Q000175:diagnosis / Q000235:genetics*
D005165:Factor V