Cytotoxic constituents of the lichen Diploicia canescens.
A new diphenyl ether (1), along with 12 known compounds, was isolated from the lichen Diploicia canescens. The structure of compound 1 was elucidated by spectroscopic data analysis, and the biosynthetic origin of this product is discussed. Secalonic acids B (7), D (8), and F (9) were isolated for the first time from D. canescens. The cytotoxic activities of 1-3, 6-8, and 10 against the B16 murine melanoma and HaCaT human keratinocyte cell lines were evaluated.
Millot
Marion
M
EA 4090 Substances Licheniques et Photoprotection, UFR des Sciences Pharmaceutiques et Biologiques, Universite de Rennes 1, 2 Avenue du Professeur Leon Bernard, 35043 Rennes Cedex, France.
Tomasi
Sophie
S
Studzinska
Elisabeth
E
Rouaud
Isabelle
I
Boustie
Joël
J
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005602:France; D006801:Humans; D008011:Lichens / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D010647:Phenyl Ethers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D010647:Phenyl Ethers; C546368:buellin