title: Modified spectrometry (O2C device) of intraoperative microperfusion predicts organ function after kidney transplantation: a pilot study.
abstract: BACKGROUND
  Delayed graft function (DGF) is defined as posttransplantation dialysis within 1 week, which might be associated with impaired long-term graft survival. The aim of our pilot study was to establish the ability of intraoperative spectrometry of allograft microperfusion to predict DGF.
  
  
  METHODS
  Twenty human kidney allografts transplanted from deceased donors were evaluated intraoperatively after reperfusion using modified organ spectrometry (O2C device). We examined hemoglobin oxygen saturation, intravascular amount of hemoglobin, and microperfusion flow/velocity.
  
  
  RESULTS
  Retrospectively, 10/20 (50%) allografts with measurable impairment of cortical hemoglobin oxygen saturation and microperfusion flow/velocity developed DGF. Retrospectively, we found that if the intravascular amount of hemoglobin was increased upon intraoperative measurement, the kidney was prone to develop DGF.
  
  
  CONCLUSIONS
  Spectrometry data predicted DGF. Our results supported the thesis that impaired microperfusion is the key to DGF and might be related to postcapillary endothelial damage or intravascular sludge.
authors.affiliation: Department of Urology, Bonn University, Bonn, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Fechner
authors.forename: J
authors.initials: J
authors.lastname: von Pezold
authors.forename: O
authors.initials: O
authors.lastname: Luzar
authors.forename: S
authors.initials: S
authors.lastname: Hauser
authors.forename: R H
authors.initials: RH
authors.lastname: Tolba
authors.forename: S C
authors.initials: SC
authors.lastname: Müller
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002102:Cadaver; D006084:Graft Rejection / Q000453:epidemiology; D006406:Hematoma / Q000209:etiology / Q000628:therapy; D006499:Hepatic Artery / Q000601:surgery; D006503:Hepatic Veins / Q000601:surgery; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods* / Q000502:physiology*; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000295:instrumentation / Q000379:methods; D010477:Perfusion; D011183:Postoperative Complications / Q000453:epidemiology; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D015607:Stents; D014019:Tissue Donors; D014184:Transplantation, Homologous / Q000379:methods; D014513:Ureter / Q000637:transplantation; D001743:Urinary Bladder / Q000601:surgery