title: Incidence of new onset metabolic acidosis following enteroplasty for myelomeningocele.
abstract: OBJECTIVE
  Extant literature is mixed regarding risk of metabolic acidosis after enteroplasty for myelomeningocele. This study is the first known attempt to describe the pattern of developing metabolic acidosis in a group of children who underwent enteroplasty and served as their own controls. Multiple preoperative and postoperative laboratory measures for each child were obtained for comparison.
  
  
  METHODS
  This retrospective cohort study allowed participants to serve as their own controls for pre-intervention and post-intervention analysis. The setting was a tertiary, university affiliated, interdisciplinary spina bifida program. All patients followed in the spina bifida program who had undergone ileal or colonic enteroplasty were included for review (total 113). Strict exclusion criteria were preoperatively diagnosed renal insufficiency, preexisting metabolic acidosis consistent with renal tubular acidosis (pH less than 7.35, bicarbonate 20 mmol/l or less) and history of augmentation using gastric or ureteral tissue. Final analysis included 71 children who met inclusion criteria. Children in our spina bifida program periodically undergo routine laboratory evaluation of electrolytes, blood urea nitrogen, creatinine, blood count, and venous blood gases including pH, bicarbonate and partial pressure of carbon dioxide. Primary outcome measures were comparative shifts in blood gases and electrolytes that would confirm the new onset of metabolic acidosis after enteroplasty. Changes in electrolytes and serum creatinine were secondary outcome measures to identify potential markers for postoperative effects. With each child as his/her own control, analysis included paired t tests.
  
  
  RESULTS
  No statistically significant differences (p <0.05) were found when comparing laboratory values before and after bladder augmentation, including pH, bicarbonate, partial pressure of carbon dioxide and electrolytes. No child had metabolic acidosis based on the aforementioned criteria. Followup ranged from 1 to 138 months after enteroplasty (mean 46.8). Respiratory compensation was considered in the analysis, and no difference in partial pressure of carbon dioxide following surgery was noted (p = 0.65).
  
  
  CONCLUSIONS
  To our knowledge no previous study has examined the matched paired results of before and after development of metabolic acidosis among children (serving as their own controls) with myelomeningocele undergoing ileal or colonic enteroplasty. The negative statistical results in this controlled cohort are clinically significant. If a child with myelomeningocele has metabolic acidosis after enteroplasty, other clinical reasons beyond the effects of surgery warrant careful consideration.
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9110, USA.
authors.forename: Richard C
authors.initials: RC
authors.lastname: Adams
authors.forename: Behroze
authors.initials: B
authors.lastname: Vachha
authors.forename: Mindy L
authors.initials: ML
authors.lastname: Samuelson
authors.forename: Amy
authors.initials: A
authors.lastname: Keefover-Hicks
authors.forename: Warren T
authors.initials: WT
authors.lastname: Snodgrass
mesh_terms: D000138:Acidosis / Q000453:epidemiology* / Q000209:etiology* / Q000378:metabolism; D002648:Child; D015331:Cohort Studies; D003106:Colon / Q000637:transplantation*; D006801:Humans; D007082:Ileum / Q000637:transplantation*; D015994:Incidence; D008591:Meningomyelocele / Q000601:surgery*; D012189:Retrospective Studies; D013520:Urologic Surgical Procedures / Q000009:adverse effects*