Polymorphism rs4934 of SERPINA3 and sporadic intracranial aneurysms in the Chinese population.
BACKGROUND
Serine protease inhibitor member 3 of clade A (SERPINA3) has been shown as a risk factor for aneurysmal subarachnoid hemorrhage in a Polish population. In the present study, the authors investigated the correlation between the rs4934 polymorphism of SERPINA3 and sporadic intracranial aneurysms in Chinese patients.


METHODS
The rs4934 polymorphism of SERPINA3 was identified by PCR and Taqman MGB probe analysis in genomic DNA from 275 patients with sporadic intracranial aneurysms (mean age 50.83 +/- 10.78 years) and 361 control participants (mean age 53.21 +/- 10.81 years). Differences in allelic and genotypic frequencies between the patient and control groups were evaluated with the chi(2) test.


RESULTS
No significant difference was found in either the genotype distribution or allelic frequencies of SERPINA3 between patients and controls.


CONCLUSIONS
The rs4934 polymorphism of SERPINA3 is not associated with sporadic intracranial aneurysms among individuals of Chinese Han ethnicity.
Liu
Wei
W
Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, China.
Zhu
Yufang
Y
Ge
Mingxu
M
Pang
Qi
Q
Yu
Yanbing
Y
D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D002532:Intracranial Aneurysm / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors; D015843:Serpins / Q000235:genetics*
C516148:SERPINA3 protein, human; D015843:Serpins