title: Prevention of chemotherapy induced nausea and vomiting: a focus on aprepitant.
abstract: BACKGROUND
  Nausea and vomiting is one of the most feared side effects of chemotherapy; however, in the past 20 years, a better understanding of the pathophysiology of chemotherapy-induced nausea and vomiting (CINV) has led to the introduction of newer antiemetics, which have improved the management of this side effect.
  
  
  OBJECTIVE
  This article reviews the prevention of CINV and the role of aprepitant, the first of the newest class of antiemetics, the neurokinin-1 inhibitors. A brief description of the pathophysiology of CINV and the background on the prevention of CINV using the 5-HT(3) antagonists is outlined. The pharmacology, pharmacokinetics, drug interactions and various clinical studies with aprepitant are reviewed.
  
  
  METHODS
  The literature about aprepitant is reviewed focusing on the role of aprepitant in the management of CINV in relationship to other commonly used antiemetics. The literature was searched regarding aprepitant and its pharmacological characteristics, pharmacokinetics, drug interactions and various clinical studies.
  
  
  CONCLUSIONS
  Aprepitant has a significant role in the management of CINV, as it allows the majority of patients to complete their chemotherapies without significant morbidity. Its use in a variety of clinical settings in cancer patients needs to be further explored.
authors.affiliation: The University of Texas Health Science Center, Institute for Drug Development at CTRC, Zeller's Building, San Antonio, TX, USA. Sankhala@uthscsa.edu
authors.forename: Kamalesh K
authors.initials: KK
authors.lastname: Sankhala
authors.forename: Devesh M
authors.initials: DM
authors.lastname: Pandya
authors.forename: John
authors.initials: J
authors.lastname: Sarantopoulos
authors.forename: Scott A
authors.initials: SA
authors.lastname: Soefje
authors.forename: Francis J
authors.initials: FJ
authors.lastname: Giles
authors.forename: Sant P
authors.initials: SP
authors.lastname: Chawla
mesh_terms: D000818:Animals; D000932:Antiemetics / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000077608:Aprepitant; D002986:Clinical Trials as Topic; D006801:Humans; D009025:Morpholines / Q000494:pharmacology / Q000627:therapeutic use*; D009325:Nausea / Q000139:chemically induced / Q000517:prevention & control*; D064729:Neurokinin-1 Receptor Antagonists; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents; D009025:Morpholines; D064729:Neurokinin-1 Receptor Antagonists; D000077608:Aprepitant