Collagenase Santyl ointment: a selective agent for wound debridement.
Enzymatic debridement is a frequently used technique for removal of necrotic tissue from wounds. Proteases with specificity to break down the collagenous materials in necrotic tissues can achieve selective debridement, digesting denatured collagen in eschar while sparing nonnecrotic tissues. This article provides information about the selectivity of a collagenase-based debriding agent, including evidence of its safe and efficacious uses. Recent research has been conducted, investigating the chemical and biological properties of collagenase ointment, including healing in animal models, digestion power on different collagen types, cell migration activity from collagen degradation products, and compatibility with various wound dressings and metal ions. Evidence presented demonstrates that collagenase ointment is an effective, selective, and safe wound debriding agent.
Shi
Lei
L
Healthpoint Ltd, Fort Worth, Texas 76107, USA. lei.shi@healthpoint.com
Carson
Dennis
D
D001458:Bandages; D002465:Cell Movement; D047009:Hathewaya histolytica / Q000201:enzymology*; D003646:Debridement / Q000379:methods*; D006801:Humans; D003012:Microbial Collagenase / Q000008:administration & dosage / Q000627:therapeutic use*; D009824:Ointments; D014947:Wounds and Injuries / Q000628:therapy*
D009824:Ointments; D003012:Microbial Collagenase