Solid-phase synthesis of protected alpha-amino phosphonic acid oligomers.
By establishing both a highly efficient phosphonamidate formation and a RuCp-catalyzed cleavage of an allyl linker, the solid-phase synthesis of Fmoc-(GlyP(OBn))(6)-OH/DIEA, a protected form of a new type of unnatural peptide alpha-amino phosphonic acid oligomer (APO), has been realized.
Ishibashi
Yoshitaka
Y
Research Center for Materials Science and the Department of Chemistry, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
Kitamura
Masato
M
D000595:Amino Acid Sequence; D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D063065:Organophosphonates / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry
D063065:Organophosphonates; D010455:Peptides; D012428:Ruthenium