title: Mansouramycins A-D, cytotoxic isoquinolinequinones from a marine streptomycete.
abstract: Chemical screening of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate Mei37 resulted in five isoquinolinequinones, four new derivatives, mansouramycin A-D (1, 3-5), and the known 3-methyl-7-(methylamino)-5,8-isoquinolinedione (2). Their structures were elucidated by NMR and MS techniques and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated significant cytotoxicity of several derivatives, with pronounced selectivity for non-small cell lung cancer, breast cancer, melanoma, and prostate cancer cells.
authors.affiliation: Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
authors.forename: Usama W
authors.initials: UW
authors.lastname: Hawas
authors.forename: Mohamed
authors.initials: M
authors.lastname: Shaaban
authors.forename: Khaled A
authors.initials: KA
authors.lastname: Shaaban
authors.forename: Michael
authors.initials: M
authors.lastname: Speitling
authors.forename: Armin
authors.initials: A
authors.lastname: Maier
authors.forename: Gerhard
authors.initials: G
authors.lastname: Kelter
authors.forename: Heinz H
authors.initials: HH
authors.lastname: Fiebig
authors.forename: Marinus
authors.initials: M
authors.lastname: Meiners
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Helmke
authors.forename: Hartmut
authors.initials: H
authors.lastname: Laatsch
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008297:Male; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013302:Streptomyces / Q000737:chemistry
chemical_list: C546300:3-(1H-indol-3-yl)-7-methylaminoisoquinoline-5,8-dione; D000970:Antineoplastic Agents; D007546:Isoquinolines