Effects of aerobic exercise training on sympathetic and renal responses to mental stress in humans.
The effects of aerobic exercise training (ET) on muscle sympathetic nerve activity (MSNA) and renal vascular responses to mental stress (MS) have not been determined in humans. We hypothesized that aerobic ET would reduce MSNA and renal vasoconstriction during MS. MSNA, mean arterial pressure (MAP), heart rate, renal blood flow velocity (RBFV), and peak oxygen uptake (V(O2peak)) were recorded in 23 healthy adults. Fourteen subjects participated in 8 wk of aerobic ET, while nine subjects served as sedentary controls (Con). ET significantly increased V(O2peak) (Delta18 +/- 1%; P < 0.001) and decreased RBFV at rest (60 +/- 4 to 48 +/- 3 cm/s; P < 0.01), whereas Con did not alter V(O2peak) or RBFV. ET did not alter resting MSNA (11 +/- 1 to 9 +/- 1 bursts/min) or MAP (84 +/- 2 to 83 +/- 2 mmHg), and these findings were similar in the Con group. MS elicited similar increases in MSNA (approximately Delta2 bursts/min; P < 0.05), MAP (approximately Delta15 mmHg; P < 0.001), and heart rate (approximately Delta20 beats/min; P < 0.001) before and after ET, and the responses were not different between ET and Con. Likewise, MS elicited similar decreases in RBFV and renal vascular conductance before and after ET, and the responses were not different between ET and Con. Perceived stress levels during MS were similar before and after the 8-wk study in both ET and Con. In conclusion, ET does not alter MSNA and renal vascular responses to MS in healthy humans.
Ray
Chester A
CA
Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. caray@psu.edu
Carter
Jason R
JR
D000328:Adult; D015308:Anaerobic Threshold / Q000502:physiology; D001642:Bicycling / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology*; D012079:Renal Circulation / Q000502:physiology; D012420:Running / Q000502:physiology; D013315:Stress, Psychological / Q000503:physiopathology* / Q000523:psychology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D014661:Vasoconstriction / Q000502:physiology