The FRAGAMP study: environmental and genetic factors in Parkinson's disease, methods and clinical features.
The Fattori di Rischio Ambientali e Genetici Associati alla Malattia di Parkinson (FRAGAMP) study is a multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in Parkinson's disease (PD). Cases and controls were enrolled from five Movement Disorder centers in Central-Southern Italy. PD was diagnosed according to Gelb's criteria while the control groups consisted of the spouses of the enrolled patients or of healthy controls matched by age and area of residence. Cases and controls underwent a standardised questionnaire and a blood sample was taken for molecular analyses. At the end of the study 585 cases and 481 control subjects (287 spouse-controls and 194 generic-controls) were enrolled. Patients had a Hoehn-Yahr score of 2.3 +/- 0.8; 85% of them took levodopa and 47% had motor complications. The FRAGAMP study represents one of the largest case-control studies carried out in Europe to investigate the possible role of environmental and genetic factors in PD.
Nicoletti
Alessandra
A
Dipartimento di Neuroscienze, Università di Catania, Via Santa Sofia 78, 95123 Catania, Italy.
Pugliese
Pierfrancesco
P
Nicoletti
Giuseppe
G
Arabia
Gennarina
G
Annesi
Grazia
G
De Mari
Michele
M
Lamberti
Paolo
P
Gallerini
Simone
S
Marconi
Roberto
R
Epifanio
Antonio
A
Morgante
Letterio
L
Cozzolino
Autilia
A
Barone
Paolo
P
Torchia
Giuseppina
G
Quattrone
Aldo
A
Zappia
Mario
M
D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D018491:Dopamine Agonists / Q000627:therapeutic use; D020820:Dyskinesias / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D004777:Environment; D005260:Female; D020022:Genetic Predisposition to Disease; D005843:Geography; D006801:Humans; D007558:Italy / Q000453:epidemiology; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012720:Severity of Illness Index; D018454:Spouses; D011795:Surveys and Questionnaires
D000978:Antiparkinson Agents; D018491:Dopamine Agonists; D007980:Levodopa