PtCl(2)-catalyzed cycloisomerization of 1,6-enynes for the synthesis of substituted bicyclo[3.1.0]hexanes.
The mild and efficient PtCl(2)-catalyzed cycloisomerization of 1,6-enynes containing a heteroatom substituent at the propargylic position is described. The reactions led to the formation of 1-alkenylbicyclo[3.1.0]hexanes in good to excellent yields or 2-(bicyclo[3.1.0]hex-1-yl)acetaldehydes in moderate yields.
Ye
Liu
L
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, International Business Incubator, Guangzhou Science Park, Guangzhou 510663, PR China.
Chen
Qian
Q
Zhang
Jiancun
J
Michelet
Véronique
V
D000079:Acetaldehyde / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D006586:Hexanes / Q000138:chemical synthesis* / Q000737:chemistry; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D017671:Platinum Compounds / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013696:Temperature
D000475:Alkenes; D000480:Alkynes; D001643:Bridged Bicyclo Compounds; D006586:Hexanes; D017671:Platinum Compounds; D012997:Solvents; C030173:platinum chloride; D000079:Acetaldehyde