title: Association of tobacco and lead exposures with attention-deficit/hyperactivity disorder.
abstract: OBJECTIVE
  The study objective was to determine the independent and joint associations of prenatal tobacco and childhood lead exposures with attention-deficit/hyperactivity disorder (ADHD), as defined by current diagnostic criteria, in a national sample of US children.
  
  
  METHODS
  Data are from the 2001-2004 National Health and Nutrition Examination Survey, a cross-sectional, nationally representative sample of the US population. Participants were 8 to 15 years of age (N = 2588). Prenatal tobacco exposure was measured by report of maternal cigarette use during pregnancy. Lead exposure was assessed by using current blood lead levels. The Diagnostic Interview Schedule for Children was used to ascertain the presence of ADHD in the past year, on the basis of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria.
  
  
  RESULTS
  A total of 8.7% (95% confidence interval [CI]: 7.3%-10.1%) of children met criteria for ADHD. Prenatal tobacco exposure (adjusted odds ratio [aOR]: 2.4 [95% CI: 1.5-3.7]) and higher current blood lead concentrations (aOR for third versus first tertile: 2.3 [95% CI: 1.5-3.8]) were independently associated with ADHD. Compared with children with neither exposure, children with both exposures (prenatal tobacco exposure and third-tertile lead levels) had an even greater risk of ADHD (aOR: 8.1 [95% CI: 3.5-18.7]) than would be expected if the independent risks were multiplied (tobacco-lead exposure interaction term, P < .001).
  
  
  CONCLUSIONS
  Prenatal tobacco and childhood lead exposures are associated with ADHD in US children, especially among those with both exposures. Reduction of these common toxicant exposures may be an important avenue for ADHD prevention.
authors.affiliation: Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA. tanya.froehlich@cchmc.org
authors.forename: Tanya E
authors.initials: TE
authors.lastname: Froehlich
authors.forename: Bruce P
authors.initials: BP
authors.lastname: Lanphear
authors.forename: Peggy
authors.initials: P
authors.lastname: Auinger
authors.forename: Richard
authors.initials: R
authors.lastname: Hornung
authors.forename: Jeffery N
authors.initials: JN
authors.lastname: Epstein
authors.forename: Joe
authors.initials: J
authors.lastname: Braun
authors.forename: Robert S
authors.initials: RS
authors.lastname: Kahn
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood / Q000453:epidemiology*; D015984:Causality; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006306:Health Surveys; D006801:Humans; D007231:Infant, Newborn; D007854:Lead / Q000097:blood; D007855:Lead Poisoning / Q000453:epidemiology*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology*; D014481:United States
chemical_list: D007854:Lead