Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous.
C1-alkyl AI-2 analogues do not induce bioluminescence in V. harveyi on their own but enhance the bioluminescence induced by AI-2 in a synergistic fashion. A new facile synthesis of AI-2 facilitates the synthesis of a diverse set of AI-2 analogues and biological screening suggests that receptors that are involved in the synergistic bioluminescence production in V. harveyi are promiscuous.
Smith
Jacqueline A I
JA
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
Wang
Jingxin
J
Nguyen-Mau
Sao-Mai
SM
Lee
Vincent
V
Sintim
Herman O
HO
D001426:Bacterial Proteins / Q000378:metabolism; D013437:Carbon-Sulfur Lyases / Q000378:metabolism; D054313:Drug Agonism; D006714:Homoserine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry*; D008163:Luminescent Measurements; D014733:Vibrio / Q000737:chemistry*
D001426:Bacterial Proteins; D007783:Lactones; C091088:N-octanoylhomoserine lactone; D006714:Homoserine; D013437:Carbon-Sulfur Lyases; C117753:LuxS protein, Bacteria