[Effects of hypoxen on morphological and functional state of the liver under of exogenous intoxication conditions].
The effects of hypoxen on the metabolic processes in the liver tissue have been investigated on experimental animals (rats) with model tetrachloromethane (CCl4) induced toxic liver damage. It is established that the drug decreases the activity of transaminases and lactate dehydrogenase, the total bilirubin level in the blood serum, and the rate of free-radical lipid oxidation in the liver. These effects of hypoxen can be considered as manifestations of the hepatoprotective activity. The efficiency of the drug under conditions of CCl4 intoxication was confirmed by the results of a histological examination.
Novikov
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VE
Klimkina
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EI
D000818:Animals; D001663:Bilirubin / Q000097:blood; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002252:Carbon Tetrachloride Poisoning / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D010647:Phenyl Ethers / Q000494:pharmacology*; D051381:Rats; D000637:Transaminases / Q000097:blood
D010647:Phenyl Ethers; C085806:olifen; D002251:Carbon Tetrachloride; D007770:L-Lactate Dehydrogenase; D000637:Transaminases; D001663:Bilirubin