title: Ultrastructural observations of chemical peeling for skin rejuvenation (ultrastructural changes of the skin due to chemical peeling).
abstract: Chemical peeling of the skin is commonly used as a means to treat photoaging, but the mechanism underlying its efficacy has not yet been fully clarified. We recently conducted chemical peeling of the skin with glycolic acid and lactic acid and observed it at the ultrastructural level. No changes in the horny layer or the upper epidermal layer were observed but there was dissociation and vacuolation between the basal cells and increases in vimentin filaments within fibroblasts and endothelial cells were seen. These findings suggest that chemical peeling of the skin with this type of agent directly induces collagen formation within the dermis and thus directly stimulates remodeling of the dermis.
authors.affiliation: Department of Dermatology, Queen's Square Medical Center, Yokohama, Japan. t.omi@queens-sq.or.jp
authors.forename: Tokuya
authors.initials: T
authors.lastname: Omi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sato
authors.forename: Kayoko
authors.initials: K
authors.lastname: Numano
authors.forename: Seiji
authors.initials: S
authors.lastname: Kawana
mesh_terms: D000328:Adult; D002615:Chemexfoliation; D003094:Collagen / Q000096:biosynthesis; D006016:Glycolates / Q000627:therapeutic use*; D006801:Humans; D019344:Lactic Acid / Q000627:therapeutic use*; D008297:Male; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure*
chemical_list: D006016:Glycolates; C031149:glycolic acid; D019344:Lactic Acid; D003094:Collagen