Novel one-pot three component reaction for the synthesis of [2-(alkylsulfanyl)imidazo[1,2-a]pyridin-3-yl](aryl)methanone.
A one-pot, three-component reaction between pyridine, phenacyl bromide, and thiocyanate is described. The reaction afforded the corresponding special type of fully substituted imidazo[1,2-a]pyridine derivatives in good yields without using any catalyst or activation.
Kianmehr
Ebrahim
E
School of Chemistry, College of Science, University of Tehran, Tehran, Iran. kianmehr@khayam.ut.ac.ir
Ghanbari
Mohammad
M
Niri
Mehri Nadiri
MN
Faramarzi
Reza
R
D000098:Acetophenones / Q000138:chemical synthesis*; D001965:Bromides / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
D000098:Acetophenones; D001965:Bromides; D011725:Pyridines; C001439:imidazo(1,2-a)pyridine