title: Long-term disease-free survivor of metastatic large-cell neuroendocrine carcinoma of the lung treated with amrubicin and irinotecan.
abstract: Large-cell neuroendocrine carcinoma (LCNEC) is a relatively uncommon variant of non-small cell lung cancer. Since the biological characteristics of LCNEC are similar to those of small cell lung cancer, LCNEC is usually treated with chemotherapy regimens used for small cell lung cancer. However, the outcomes are usually dismal. Here, we report a patient with LCNEC (a metastasis to the brain). After whole brain irradiation, he received a combination of amrubicin and irinotecan chemotherapy, and has been relapse-free for two years. This treatment regimen may be beneficial for patients with advanced LCNEC.
authors.affiliation: Department of Respiratory Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Ryuge
authors.forename: Shi-Xu
authors.initials: SX
authors.lastname: Jiang
authors.forename: Mayuko
authors.initials: M
authors.lastname: Wada
authors.forename: Ken
authors.initials: K
authors.lastname: Katono
authors.forename: Maiko
authors.initials: M
authors.lastname: Iwasaki
authors.forename: Akira
authors.initials: A
authors.lastname: Takakura
authors.forename: Sakiko
authors.initials: S
authors.lastname: Otani
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kimura
authors.forename: Tomoya
authors.initials: T
authors.lastname: Fukui
authors.forename: Masanori
authors.initials: M
authors.lastname: Yokoba
authors.forename: Masaru
authors.initials: M
authors.lastname: Kubota
authors.forename: Masato
authors.initials: M
authors.lastname: Katagiri
authors.forename: Kazusige
authors.initials: K
authors.lastname: Hayakawa
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Masuda