Continuous estrogen decreases neurokinin B expression in the rat arcuate nucleus.
Immunohistochemical and in situ hybridization histochemical techniques were used to identify neurokinin B (NKB, also known as neuromedin K or neurokinin beta) as the predominant tachykinin present in cells of the arcuate nucleus of the rat. Little is known about the function of NKB; however, its localization in the arcuate nucleus and the observation that Silastic implants of estrogen for 2 weeks decreases the numbers of labeled cells sutgest a role in gonadal steroid-dependent mechanisms that regulate the anterior pituitary.
Akesson
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Department of Anatomy and Cell Biology and the Laboratory of Neuroendocrinology, UCLA School of Medicine, Los Angeles, California 90024, USA; Department of Medicine and Center for Ulcer Research and Education, Wadsworth Veterans Administration, UCLA School of Medicine, Los Angeles, California 90024, USA.
Sternini
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Micevych
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PE