title: alpha-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: a structure-activity relationships approach.
abstract: alpha-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents. In this review the structural features of (N)-TSCs, required for maximum antitumour activity have been explored. Special attention is given to the mechanisms of action and structure-activity relationships.
authors.affiliation: Departamento de Química Inorgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, c/ Francisco Tomás y Valiente n 7, 28049-Madrid, Spain. ana.matesanz@uam.es
authors.forename: Ana I
authors.initials: AI
authors.lastname: Matesanz
authors.forename: Pilar
authors.initials: P
authors.lastname: Souza
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000737:chemistry; D008670:Metals / Q000737:chemistry; D008968:Molecular Conformation; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors / Q000378:metabolism; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds; D008670:Metals; D013882:Thiosemicarbazones; D012264:Ribonucleotide Reductases