Determination of parabens in cosmetic products using multi-walled carbon nanotubes as solid phase extraction sorbent and corona-charged aerosol detection system.
The potential of carbon nanotubes for the solid phase extraction of parabens in cosmetic products and the detection using a corona-charged aerosol detector (C-CAD) is presented in this work. The analytical procedure is based on a conventional solid phase extraction step for which 20mg of multi-walled carbon nanotubes were packed in a 3-mL commercial SPE cartridge. Methylparaben, ethylparaben, propylparaben and butylparaben were thus isolated and preconcentrated from the pre-treated samples and subsequently separated on a RP-C18 column using acetonitrile:water, 50:50 (v/v) as mobile phase. The analytical signals for the individual parabens were obtained using C-CAD. The experimental variables affecting the extraction procedure and the instrumental detection have been deeply studied. Limits of detection were in the range of 0.5-2.1mgL(-1), while the linear range was extended up to 400mgL(-1). The average precision of the method varied between 3.3-3.8% (repeatability) and 4.3-7.6% (reproducibility). Finally, the optimized procedure was applied to the determination of the target preservatives in a variety of cosmetic products with satisfactory results.
Márquez-Sillero
Isabel
I
Department of Analytical Chemistry, Marie Curie Building (Annex), Campus de Rabanales, University of Córdoba, E-14071 Córdoba, Spain.
Aguilera-Herrador
Eva
E
Cárdenas
Soledad
S
Valcárcel
Miguel
M
D000327:Adsorption; D000336:Aerosols; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods; D003358:Cosmetics / Q000737:chemistry*; D057230:Limit of Detection; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010226:Parabens / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000295:instrumentation / Q000379:methods*
D000336:Aerosols; D003358:Cosmetics; D037742:Nanotubes, Carbon; D010226:Parabens