title: [Polymorphous low-grade adenocarcinoma: about two cases].
abstract: BACKGROUND
  Polymorphous low-grade adenocarcinoma (APBG) is a variant of malignant tumour of minor salivary glands usually arising in the palate.
  
  
  OBJECTIVE
  Our aim is to discuss morphology, evolution and differential diagnosis of this rare tumour.
  
  
  METHODS
  The first case interested a 65-year-old-woman admitted for a two-months-history of a right submaxillary swelling. Examination found a tumour of the right side of the palate. A biopsy concluded to a pleomorphic adenoma. Giving that the mass enlarged, a surgical resection carrying off the thyroid with a bilateral neck dissection was performed. Diagnosis was an APBG partially resected with lymph node metastasis. The patient received adjuvant radiotherapy. Local recurrence appeared 28 months after treatment. The second case interested a 57-year-old-woman who consulted for a 12-year-history of a swelling of the lower lip. Clinical examination showed a painless nodule measuring 2 cm located in the mucosal side of the lower lip. An excisional biopsy was performed. Pathologic examination concluded to an APBG completely resected. The patient had no evidence of disease with a follow-up of 54 months.
  
  
  CONCLUSIONS
  APBG is characterised by a morphologic diversity and a cytologic uniformity that may cause a diagnostic dilemma especially with adenoid cystic carcinoma and pleomorphic adenoma. Its aggressiveness is assessed by its local infiltrative growth pattern requiring a wide surgical excision.
authors.affiliation: Laboratoire d'Anatomie et de Cytologie Pathologiques, CHU Habib Bourguiba, Sfax.
authors.forename: Lobna
authors.initials: L
authors.lastname: Ayadi
authors.forename: Salma
authors.initials: S
authors.lastname: Chaâbouni
authors.forename: Houria
authors.initials: H
authors.lastname: Dhouib
authors.forename: Karima
authors.initials: K
authors.lastname: Abbès
authors.forename: Morched
authors.initials: M
authors.lastname: Dhouib
authors.forename: Saloua
authors.initials: S
authors.lastname: Makni
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abdelmoula
authors.forename: Abdelmonem
authors.initials: A
authors.lastname: Ghorbel
authors.forename: Abdelmajid
authors.initials: A
authors.lastname: Khabir
authors.forename: Tahya
authors.initials: T
authors.lastname: Boudawara
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D012470:Salivary Glands, Minor