Application of independent component analysis for the data mining of simultaneous Eeg-fMRI: preliminary experience on sleep onset.
The simultaneous acquisition of electroencephalogram (EEG) and functional MRI (fMRI) signals is potentially advantageous because of the superior resolution that is achieved in both the temporal and spatial domains, respectively. However, ballistocardiographic artifacts along with ocular artifacts are a major obstacle for the detection of the EEG signatures of interest. Since the sources corresponding to these artifacts are independent from those producing the EEG signatures, we applied the Infomax-based independent component analysis (ICA) technique to separate the EEG signatures from the artifacts. The isolated EEG signatures were further utilized to model the canonical hemodynamic response functions (HRFs). Subsequently, the brain areas from which these EEG signatures originated were identified as locales of activation patterns from the analysis of fMRI data. Upon the identification and subsequent evaluation of brain areas generating interictal epileptic discharge (IED) spikes from an epileptic subject, the presented method was successfully applied to detect the theta and alpha rhythms that are sleep onset-related EEG signatures along with the subsequent neural circuitries from a sleep-deprived volunteer. These results suggest that the ICA technique may be useful for the preprocessing of simultaneous EEG-fMRI acquisitions, especially when a reference paradigm is unavailable.
Lee
Jong-Hwan
JH
Department of Radiology Brigham and Women's Hospital, Harvard Medical School, MA, USA.
Oh
Sungsuk
S
Jolesz
Ferenc A
FA
Park
Hyunwook
H
Yoo
Seung-Schik
SS
D000328:Adult; D000465:Algorithms; D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology; D003627:Data Interpretation, Statistical; D016208:Databases, Factual; D004569:Electroencephalography / Q000706:statistics & numerical data*; D004827:Epilepsy / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D025341:Principal Component Analysis; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000503:physiopathology; D012984:Software