title: Intranasal infusion of clotrimazole for the treatment of nasal aspergillosis in two cats.
abstract: METHODS
  2 cats (13 and 11 years old) were evaluated to determine the cause of nasal discharge of varying duration (4 days and 5 months, respectively).
  
  
  RESULTS
  Computed tomography revealed marked turbinate destruction and soft tissue densities in the nasal passages. Histologic examination of nasal specimens revealed chronic active inflammation and branching fungal hyphae consistent with Aspergillus spp. Fungal culture of nasal specimens resulted in growth of Aspergillus spp. Testing yielded negative results for antibodies against Aspergillus spp.
  
  
  RESULTS
  Both cats were anesthetized and treated with a 1-hour intranasal infusion of clotrimazole. Recovery from the procedure was uncomplicated, and both cats had complete resolution of clinical signs.
  
  
  CONCLUSIONS
  Little information is available on the treatment of nasal aspergillosis in cats, and the prognosis for affected animals is considered poor. The procedure for local intranasal infusion of clotrimazole in 2 cats was described here. Results and follow-up monitoring for both cats suggested that this may be a safe, effective, and durable treatment for cats with nasal aspergillosis.
authors.affiliation: Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. furro004@umn.edu
authors.forename: Eva
authors.initials: E
authors.lastname: Furrow
authors.forename: Reid P
authors.initials: RP
authors.lastname: Groman
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001228:Aspergillosis / Q000628:therapy / Q000662:veterinary*; D002371:Cat Diseases / Q000188:drug therapy* / Q000382:microbiology; D002415:Cats; D003022:Clotrimazole / Q000008:administration & dosage* / Q000627:therapeutic use*; D005260:Female; D009668:Nose Diseases / Q000382:microbiology / Q000628:therapy / Q000662:veterinary*
chemical_list: D000935:Antifungal Agents; D003022:Clotrimazole