title: Epigenetic inheritance in mammals: evidence for the impact of adverse environmental effects.
abstract: The epigenome is the overall epigenetic state of a cell and represents the ensemble of chromatin modifications. It is an essential mechanism for the regulation of the genome that depends on modifications of DNA and histones but does not involve any change of the DNA sequence. It was previously assumed that in order for appropriate cellular development and differentiation to occur in mammals, the epigenome was fully erased and reestablished between generations. However, several examples of incomplete erasure at specific genes have been reported, and this is suggested to be associated with the epigenetic inheritance of gene profiles. Although the existence of such a mode of inheritance has been controversial, there is increasing evidence that it does occur in rodents and humans. In this review, we discuss the evidence that adverse environmental factors can affect not only the individuals directly exposed to these factors but also their offspring. Because the epigenome is sensitive to environmental influence and, in some cases, can, in part, be transmitted across generations, it provides a potential mechanism for the transgenerational transmission of the impact of environmental factors. Environmental factors examined include exposure to toxicants, diet, and postnatal care, and DNA methylation is the main mechanism discussed in this review.
authors.affiliation: Brain Research Institute, Medical Faculty of the University of Zürich and Department of Biology, Swiss Federal Institute of Technology, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Franklin
authors.forename: Isabelle M
authors.initials: IM
authors.lastname: Mansuy
mesh_terms: D000818:Animals; D004777:Environment; D044127:Epigenesis, Genetic / Q000235:genetics*; D015386:Hazardous Substances / Q000009:adverse effects / Q000378:metabolism; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics*; D008322:Mammals / Q000235:genetics* / Q000378:metabolism; D009747:Nutritional Physiological Phenomena / Q000235:genetics
chemical_list: D015386:Hazardous Substances