Is there a link between gastroesophageal reflux disease and atrial fibrillation?
BACKGROUND
Previous studies suggest a potential association between gastroesophageal reflux disease (GERD) and atrial fibrillation.


OBJECTIVE
To explore the potential association between GERD and atrial fibrillation.


METHODS
This was a retrospective study created from a database containing all health care encounters for patients who received ambulatory care in the National Capitol Area military health care system between January 1, 2001 and October 28, 2007. The study population included all subjects at least 18 years of age (n = 163 627). Our primary outcomes of interest were International Classification of Diseases, Ninth Revision (ICD-9) diagnoses of atrial fibrillation and GERD.


RESULTS
Among 163 627 patients, 7992 (5%) had atrial fibrillation and 47 845 (29%) had GERD. The presence of GERD increased the relative risk (RR) of a diagnosis of atrial fibrillation (RR: 1.39, 95% confidence interval [CI]: 1.33-1.45). In sensitivity analyses, this relationship persisted after adjustment for cardiovascular disease risk factors (RR: 1.19, 95% CI: 1.13-1.25) and diagnoses known to be strongly associated with atrial fibrillation (RR: 1.08, 95% CI: 1.02-1.13).


CONCLUSIONS
The presence of GERD is associated with an increased risk of a diagnosis of atrial fibrillation.
Kunz
Jeffrey S
JS
Cardiology Service, Walter Reed Army Medical Center, Washington, DC, USA. jeffrey.kunz@amedd.army.mil
Hemann
Brian
B
Edwin Atwood
J
J
Jackson
Jeffrey
J
Wu
Timothy
T
Hamm
Carolyn
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D055815:Young Adult