Chronic immune thrombocytopenia in children: epidemiology and clinical presentation.
Immune thrombocytopenic purpura (ITP) is one of the most common acquired bleeding disorders in children. Most children with ITP will have acute disease, self-limited thrombocytopenia that resolves completely within weeks or months, with or without therapy. A small subset of children with ITP has clinically significant disease with severe thrombocytopenia and/or bleeding that requires intervention. Treatment for these children is an ongoing clinical challenge, as few therapies offer long-term remission, and all have significant side effects and toxicities. This article focuses on the management of clinically significant chronic ITP in the pediatric population.
Bennett
Carolyn M
CM
Aflac Cancer Center and Blood Disorders Service, Emory University School of Medicine and Children's Healthcare of Atlanta, 5455 Meridian Mark Road, Suite 400, Atlanta, GA 30342, USA. carolyn.bennett@choa.org
Tarantino
Michael
M
D002648:Child; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D006801:Humans; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy