title: Reinforcement of tendon attachment to bioactive porous titanium by BMP-2-induced ectopic bone formation.
abstract: Achieving a firm attachment between a tendon and a metal remains a major challenge in orthopedic surgery. In this study, we developed a simple model for evaluating the strength of this attachment using bioactive porous titanium, and confirmed whether bone morphogenic protein-2 (BMP-2) can be a help in achieving a firm attachment by ectopic bone formation. Rectangular plate-shaped implants were soak-loaded with BMP-2 (B+ group) and were implanted within the patellar tendon of a rabbit. Implants without BMP-2 (B- group) were used as controls, and they were harvested at 4 and 8 weeks postoperation for mechanical tests and for histological and histomorphometric study. The pull-out failure load of the B+ group was significantly higher than that of the B- group and new bone was more prevalent within the pores and around the implants in the B+ group than in the B- group. The model used in this study was feasible for evaluating the tendon-metal attachment, and a combination of bioactive porous titanium and BMP-2 was found to attach firmly to the tendon.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-kawahara-cho, Sakyo-ku 606-8507, Kyoto, Japan. so_kazu@kuhp.kyoto-u.ac.jp
authors.forename: Kazutaka
authors.initials: K
authors.lastname: So
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Takemoto
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Fujibayashi
authors.forename: Masashi
authors.initials: M
authors.lastname: Neo
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kokubo
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D055396:Bone Morphogenetic Protein 2 / Q000737:chemistry*; D001842:Bone and Bones / Q000473:pathology; D016503:Drug Delivery Systems; D008297:Male; D009985:Orthopedics / Q000379:methods; D016348:Osseointegration; D016062:Porosity; D011474:Prosthesis Design; D011817:Rabbits; D013314:Stress, Mechanical; D013710:Tendons / Q000473:pathology*; D013997:Time Factors; D014025:Titanium / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D055396:Bone Morphogenetic Protein 2; D014025:Titanium