Advances in thymosin beta10 research: differential expression, molecular mechanisms, and clinical implications in cancer and other conditions.
Thymosin beta 10 (Tbeta10) is a member of the beta-thymosin family, which has biological activities as an actin-sequestering protein involved in cell motility. Tbeta10 may be correlated with tumor biology such as cell proliferation, apoptosis, angiogenesis, and metastasis behavior. However, the molecular mechanisms of action of Tbeta10 in cancer are largely unknown. Tbeta10 is differentially expressed in embryogenesis and neuronal development. Its expression is also increased in many inflammatory conditions and tumorigenesis. This review briefly summarizes recent advances in Tbeta10 research including differential expression, functions, mechanisms, gene regulation, and therapeutic applications in cancer, wound healing, and other diseases.
Sribenja
Sirinapa
S
Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
Li
Min
M
Wongkham
Sopit
S
Wongkham
Chaisiri
C
Yao
Qizhi
Q
Chen
Changyi
C
D000199:Actins / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D002465:Cell Movement; D049109:Cell Proliferation; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000378:metabolism; D055495:Neurogenesis; D009474:Neurons / Q000378:metabolism; D015398:Signal Transduction; D013947:Thymosin / Q000235:genetics / Q000378:metabolism*; D014945:Wound Healing
D000199:Actins; D013947:Thymosin; C039302:thymosin beta(10)