Synthesis, phytotoxic, cytotoxic, acetylcholinesterase and butrylcholinesterase activities of N,N'-diaryl unsymmetrically substituted thioureas.
Fourteen N,N'-diaryl unsymmetrically substituted thioureas were synthesised and their cytotoxic (in vitro), phytotoxic (in vitro), acetylcholinesterase and butrylcholinesterase activities were determined. Thiourea 16 exhibited high, and 1 and 3 showed significant phytotoxic activity. Thioureas 1, 3, 4, 6 and 10 showed significant activity and 2, 6 and 7 indicated moderate cytotoxic activities. Compound 12 exhibited butrylcholinesterase activity higher than a standard reference.
Begum
Saeedan
S
H.E.J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-5270, Pakistan.
Choudhary
M Iqbal
MI
Khan
Khalid M
KM
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D029064:Araceae / Q000187:drug effects*; D001156:Artemia / Q000187:drug effects*; D002091:Butyrylcholinesterase / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013890:Thiourea / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D013890:Thiourea