title: Self-assembled nanostructures of oleic acid and their capacity for encapsulation and controlled delivery of nutrients.
abstract: A simple preparation method for a nutrient delivery system is presented using nanostructures of oleic acid embedded in canola oil by a two step synthesis procedure. Oleic acid nanostructures in the form of micelles and vesicles were initially prepared and their ability to encapsulate vitamin-C, used as a model nutrient, was evaluated. Dynamic Light Scattering (DLS) analysis and Transmission Electron Microscopy (TEM) confirmed the formation of micelles and vesicles with diameters of 150 nm and 540 nm respectively. Supramolecular structural transformations were observed at specific temperatures, and coincided with the release of a considerable amount of encapsulants followed by a controlled and time bounded release. UV-Vis spectroscopy and various other thermochemical analytical techniques were employed to illustrate the structural transformations and specific environmental stimuli-responsive release of encapsulated materials. The nutrition-enriched nanostructures were successfully transferred to canola oil and the physico-chemical properties evaluated.
authors.affiliation: Alberta Lipid Utilization Program, Department of Agricultural Food and Nutritional Science, 4-10 Agriculture Life and Environmental Studies, University of Alberta, Edmonton, Canada.
authors.forename: Sinoj
authors.initials: S
authors.lastname: Abraham
authors.forename: Suresh S
authors.initials: SS
authors.lastname: Narine
mesh_terms: D002214:Capsules; D003460:Crystallization / Q000379:methods*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D019587:Dietary Supplements / Q000032:analysis*; D004339:Drug Compounding / Q000379:methods; D005502:Food; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods*; D019301:Oleic Acid / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D046911:Macromolecular Substances; D019301:Oleic Acid