On-line UV spectrophotometric analysis for organic chemistry of novel inorganic polymer derived microreactor.
The use of microfluidic or lab-on-a-chip system has shown great promise for many applications. We have previously reported fabrication and application of preceramic polymer derived chemically and mechanically stable microfluidic devices in organic synthesis. Even though organic reactions are successfully performed, it is hard to analyze product to evaluate yields without any time delay except for integration of detecting module in the devices. Moreover small sample volume makes it even difficult to analyze sample by conventional analytical tools. Removal of catalyst and by product before analysis is another hurdle in evaluating performance of microrector. In this paper we describe preliminary results for simple on-line (real-time) quantitative analysis of microchemical reaction in preceramic polymer derived microreactor without reconstruction of microreactor or expensive components. A commercial UVNIS spectrophotometer is used to monitor well established Knoevenagel reaction. To evaluate the performance of presented on-line UV/IS monitoring system, UV/IS data are compared with off-line gas chromatography based analysis system.
Cheon
Jin-Ho
JH
Department of Fine Chemical Engineering and Chemistry, Chungnam National University, Daejeon 305-764, South Korea.
Yoon
Tae-Ho
TH
Hong
Lan-Young
LY
Park
Sang-Hee
SH
Kim
Dong-Pyo
DP
D004867:Equipment Design; D019544:Equipment Failure Analysis; D017022:Flow Injection Analysis / Q000295:instrumentation*; D007287:Inorganic Chemicals / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D008904:Miniaturization; D049329:Nanostructures / Q000737:chemistry*; D009862:Online Systems; D009930:Organic Chemicals / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet / Q000295:instrumentation*
D007287:Inorganic Chemicals; D009930:Organic Chemicals