Dendritic cell subsets in primary and secondary T cell responses at body surfaces.
We examine the role of dendritic cells subsets in immunity to peripheral infections, with emphasis on the differences in the regulation of primary and secondary T cell responses to viruses. Our major focus is on new developments in the understanding of immunity to infections of the skin and lung, which are crucial entry points for a variety of infectious pathogens. Initially we describe a diverse network of dendritic cell subsets, but then we argue for a more generalized model of reduced complexity.
Heath
William R
WR
The Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia. wrheath@unimelb.edu.au
Carbone
Francis R
FR
D000818:Animals; D002465:Cell Movement; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D011014:Pneumonia / Q000276:immunology*; D012874:Skin Diseases, Infectious / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*