Changes in CREB (SER133) content and DNA-binding activity of transcriptional factors in rat brain cells against the background of ladasten exposure.
We studied the effects of single administration of ladasten (50 mg/kg) on the level of transcriptional factor CREB (cyclic AMP response binding element protein) phosphorylated by Ser133 in rat striatum, hypothalamus, and hippocampus. Transcriptional factors with affected DNA-binding activity were identified in brain cells.
Salimgareeva
M Kh
MKh
Laboratory of Molecular Immunology and Pharmacology, Institute of Biochemistry and Genetics, Ufa Research Centre, Russian Academy of Sciences, Moscow, Russia. milyausha78@mail.ru
Vakhitova
Yu V
YV
Yamidanov
R S
RS
Sadovnikov
S V
SV
Seredenin
S B
SB
D000218:Adamantane / Q000031:analogs & derivatives* / Q000633:toxicity; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011485:Protein Binding / Q000187:drug effects; D051381:Rats
D017362:Cyclic AMP Response Element-Binding Protein; C493151:N-(2-adamantyl)-N-p-bromophenylamine; D004247:DNA; D000218:Adamantane