Combined analysis of smoking, TP53, and FGFR3 mutations in Tunisian patients with invasive and superficial high-grade bladder tumors.
In our cohort, FGFR3 mutations were detected in 31.1% of bladder tumors and are associated with lower stage and grade. Concerning TP53, 62 mutations were found in tumors from 44 cases (48.88%) and are associated with advanced forms. The combined analysis of FGFR3 and TP53 mutations in our cohort showed an independent distribution. In addition, we have reported that FGFR3 mutations spectrum depends on the intensity of tobacco use (pack years: PY). Finally, we have found that the FGFR3wt/TP53mut genotype, which was associated with advanced bladder tumors; was overrepresented in light smokers (PY < 40) compared to nonsmoker patients (p =.01).
Ouerhani
Slah
S
Laboratory of Genetic, Immunology and Human Pathology, Faculty of Sciences of Tunis, El Mannar I, 2092 Tunis, Tunisia. slah_mekni@yahoo.fr
Rouissi
Kamel
K
Kourda
Nadia
N
Marrakchi
Raja
R
Bougatef
Karim
K
Riadh Ben Slama
Mohamed
M
Sfaxi
Mohamed
M
Chebil
Mohamed
M
Ben Jilani
Sarra
S
Benammar Elgaaied
Amel
A
D000368:Aged; D044383:Black People / Q000235:genetics*; D002277:Carcinoma / Q000208:ethnology / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D005091:Exons; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D016017:Odds Ratio; D010641:Phenotype; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000208:ethnology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D014416:Tunisia / Q000453:epidemiology; D001749:Urinary Bladder Neoplasms / Q000208:ethnology / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D019459:Urothelium / Q000473:pathology
C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C496365:FGFR3 protein, human; D051498:Receptor, Fibroblast Growth Factor, Type 3