title: Specific self-antigen-driven immune response in pericardial effusion as an isolated GVHD manifestation.
abstract: Pericardial effusion and cardiac tamponade have been described as GVHD manifestations in the post transplant period. Direct evidence of GVHD-related TCR or B-cell receptor clones in patients with pericardial effusion has never been described. Using several methods, including FACS and spectratyping analysis to assess T- and B-cell clonality and to quantify TCR excision circles to assess newly thymus-derived T cells, we were able to show expansion of oligoclonal T-cell populations and the possible presence of early/premature B cells in the pericardial effusion but not in peripheral mononuclear cells. This may explain the presentation of an isolated GVHD manifestation.
authors.affiliation: Cancer Research Center, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Lev
authors.forename: N
authors.initials: N
authors.lastname: Amariglio
authors.forename: Z
authors.initials: Z
authors.lastname: Spirer
authors.forename: U
authors.initials: U
authors.lastname: Katz
authors.forename: B
authors.initials: B
authors.lastname: Bielorai
authors.forename: G
authors.initials: G
authors.lastname: Rechavi
authors.forename: R
authors.initials: R
authors.lastname: Somech
mesh_terms: D000328:Adult; D001324:Autoantigens / Q000276:immunology*; D001402:B-Lymphocytes / Q000473:pathology; D049109:Cell Proliferation; D002999:Clone Cells / Q000276:immunology / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D006086:Graft vs Host Disease / Q000276:immunology* / Q000473:pathology; D006402:Hematologic Diseases / Q000150:complications / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007109:Immunity; D008297:Male; D008875:Middle Aged; D010490:Pericardial Effusion / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology; D055815:Young Adult
chemical_list: D001324:Autoantigens