Biomarkers of disease activity, cure, and relapse in tuberculosis.
The changing face of tuberculosis, with epidemics fueled by HIV and urbanization in much of the world and a relative increase in the importance of latent tuberculosis as a source of cases in the more economically developed countries, has led to a demand for more robust, clinically applicable diagnostic tools. As a result, research aiming to identify biomarkers of Mycobacterium tuberculosis infection and disease has flourished. This article discusses the most recent findings of that work.
Doherty
T Mark
TM
Department of Infectious Disease Immunology, Statens Serum Institute, Artillerivej 5, 2300 København S, Denmark. tmd@ssi.dk
Wallis
Robert S
RS
Zumla
Alimuddin
A
D000907:Antibodies, Bacterial / Q000032:analysis*; D015415:Biomarkers / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D003937:Diagnosis, Differential; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014374:Tuberculin Test / Q000379:methods*; D014376:Tuberculosis / Q000175:diagnosis* / Q000378:metabolism
D000907:Antibodies, Bacterial; D015415:Biomarkers; D016207:Cytokines