New antibacterial and cytotoxic activities of falcarindiol isolated in Crithmum maritimum L. leaf extract.
Bioassay-guided fractionation of a chloroformic extract obtained from Crithmum maritimum leaves led to the chemical isolation of falcarindiol, a polyacetylene widely distributed within the Apiaceae family. Structure of this compound was confirmed by NMR and activity was tracked using a screening microplate bioassay. Falcarindiol strongly inhibited the growth of Micrococcus luteus and Bacillus cereus, with a minimum inhibitory concentration (MIC) value of 50 microg ml(-1). Moreover, this compound showed cytotoxicity against IEC-6 cells with an IC50 value of 20 microM after 48 h of exposition. These results suggest that Crithmum maritimum could be potentially used in food manufactures and cosmetology as preservative agents and biopesticides, or in medicine as new antibiotics, confirming the interest in studying halophytic species as sources of bioactive compounds.
Meot-Duros
Laetitia
L
Laboratoire d'Ecophysiologie et de Biotechnologie des Halophytes et des Algues Marines, EA 3877 (LEBHAM), Institut Universitaire Européen de la Mer, Université de Bretagne Occidentale, Technopôle Brest Iroise, Place Nicolas Copernic, 29280 Plouzané, France. laetitia.meot@univ-brest.fr
Cérantola
Stéphane
S
Talarmin
Hélène
H
Le Meur
Christophe
C
Le Floch
Gaëtan
G
Magné
Christian
C
D000818:Animals; D019661:Apiaceae / Q000737:chemistry*; D001409:Bacillus cereus / Q000187:drug effects / Q000254:growth & development; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005591:Chemical Fractionation; D053280:Diynes / Q000032:analysis / Q000494:pharmacology*; D020895:Enterocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005233:Fatty Alcohols / Q000032:analysis / Q000494:pharmacology*; D005562:Formazans / Q000378:metabolism; D007421:Intestine, Small; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects / Q000254:growth & development; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D013778:Tetrazolium Salts / Q000378:metabolism
D053280:Diynes; D005233:Fatty Alcohols; D005562:Formazans; D010936:Plant Extracts; D013778:Tetrazolium Salts; C079782:MTT formazan; C034379:falcarindiol