title: GH-releasing peptide-2 does not stimulate arginine vasopressin secretion in healthy men.
abstract: Ghrelin has a stimulating effect on arginine vasopressin (AVP). However, it is not known whether GHRP-2, a synthetic ghrelin receptor agonist, also has a stimulating effect on AVP release in men. To determine whether the GHRP-2 test is useful for assessing AVP secretion, blood ACTH, GH, FSH, LH, PRL, TSH and AVP levels, as well as glucose, osmolality, sodium and hematocrit, were measured before and 15, 30, 45 and 60 min after an intravenous bolus of 100 microg GHRP-2 in 10 healthy men with and without fasting. Blood pressure was measured at 15-min intervals. AVP secretion was not stimulated by the GHRP-2 test with and without fasting. There were no significant differences in hematocrit, blood pressure and plasma osmolality before and after GFRP-2 injection, although significant (p<0.001) peak blood GH, and ACTH and PRL levels were observed 30 and 15 min after GHRP-2 injection with and without fasting, respectively, and the maximal peaks were significantly (p<0.05) higher with fasting than without fasting. These results suggest that AVP secretion is not stimulated by the GHRP-2 test both with and without fasting, though GH, ACTH and PRL levels were higher with than without fasting.
authors.affiliation: The Center of Diabetes and Endocrine & Metabolism Disease, Nagaoka Red Cross Hospital, Nagaoka, Niigata, Japan. kkam-int@echigo.ne.jp
authors.forename: Kyuzi
authors.initials: K
authors.lastname: Kamoi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Minagawa
authors.forename: Keita
authors.initials: K
authors.lastname: Kimura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ishizawa
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Ohara
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Uemura
authors.forename: Junpei
authors.initials: J
authors.lastname: Tsuchiya
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D001127:Arginine Vasopressin / Q000378:metabolism*; D005215:Fasting; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D008297:Male; D009842:Oligopeptides; D009994:Osmolar Concentration; D014556:Urine / Q000737:chemistry
chemical_list: D009842:Oligopeptides; D001127:Arginine Vasopressin; D019382:Human Growth Hormone; D000324:Adrenocorticotropic Hormone; C091874:growth hormone-releasing peptide-2