title: Chapter 9 - Nanoliposomal dry powder formulations.
abstract: Liposomal dry powder formulations (DPFs) have proven their superiority over conventional DPFs due to favorably improved pharmacokinetics and pharmacodynamics of entrapped drugs, and thus, reduced local and systemic toxicities. Nanoliposomal DPFs (NLDPFs) provide stable, high aerosolization efficiency to deep lung, prolonged drug release, slow systemic dilution, and avoid macrophage uptake of encapsulated drug by carrier-based delivery of nano-range liposomes. This chapter describes methods of preparation of nanoliposomes (NLs) and NLDPFs, using various techniques, and their characterization with respect to size distribution, flow behavior, in vitro drug release profile, lung deposition, cellular uptake and cytotoxicity, and in vivo pharmacokinetics and pharmacodynamics. Some examples have been detailed for better understanding of the methods of preparation and evaluation of NLDPFs by investigators.
authors.affiliation: TIFAC-CORE in NDDS, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Kalabhavan, Vadodara, Gujarat, India.
authors.forename: Gaurang
authors.initials: G
authors.lastname: Patel
authors.forename: Mahavir
authors.initials: M
authors.lastname: Chougule
authors.forename: Mandip
authors.initials: M
authors.lastname: Singh
authors.forename: Ambikanandan
authors.initials: A
authors.lastname: Misra
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D011208:Powders
chemical_list: D008081:Liposomes; D011208:Powders