title: Use of "spydergrams" to present and interpret SF-36 health-related quality of life data across rheumatic diseases.
abstract: The Medical Outcomes Study Short Form-36 (SF-36) is a generic measure of health-related quality of life (HRQOL), validated and cross-culturally translated, which has been extensively utilised in rheumatology. In randomised controlled trials and observational studies, SF-36 provides rich data regarding HRQOL; but as typically portrayed, patterns of disease and treatment-associated effects can be difficult to discern. "Spydergrams" offer a simplified means to visualise complex results across all domains of SF-36 in a single figure: depicting disease and population-specific patterns of decrements in HRQOL compared with age and gender-matched normative data, as well as providing a tool for interpreting complex treatment-associated or longitudinal changes. Utilising spydergrams as a standard format to illustrate and report changes in SF-36 across different rheumatic diseases can greatly facilitate analyses and interpretations of clinical trial results, as well as providing patients an accessible means to compare baseline scores and treatment-associated improvements with normative data from individuals without arthritis. Furthermore, SF-6D utility scores based on mean changes across all eight domains of SF-36 are suggested as a quantitative means of summarising changes illustrated by spydergrams, offering a universal metric for cost-effectiveness analyses of therapeutic interventions.
authors.affiliation: Division of Immunology/Rheumatology, Stanford University School of Medicine, Stanford, California, USA. vstrand@stanford.edu
authors.forename: V
authors.initials: V
authors.lastname: Strand
authors.forename: B
authors.initials: B
authors.lastname: Crawford
authors.forename: J
authors.initials: J
authors.lastname: Singh
authors.forename: E
authors.initials: E
authors.lastname: Choy
authors.forename: J S
authors.initials: JS
authors.lastname: Smolen
authors.forename: D
authors.initials: D
authors.lastname: Khanna
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D003626:Data Display; D003627:Data Interpretation, Statistical; D006305:Health Status Indicators; D006801:Humans; D011594:Psychometrics; D011788:Quality of Life; D012216:Rheumatic Diseases / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents