Characteristics of apolipoprotein M and its relation to atherosclerosis and diabetes.
Apolipoprotein M (apoM) is a novel apolipoprotein belonging to the lipocalin protein superfamily. In humans, the apoM gene is mainly expressed in the liver and kidney, where it is highly regulated by transcription factors, hormones, and cytokines. Recent studies have shown that apoM expression is reduced in some patients with diabetes and that it has a paradoxical effect on atherosclerosis. Here, we review the progress made in understanding the structure, distribution, and regulation of apoM and its potential role in lipoprotein metabolism, diabetes, and atherosclerosis.
Hu
Yan-Wei
YW
Laboratory Medicine Center, Nangfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Zheng
Lei
L
Wang
Qian
Q
D001053:Apolipoproteins / Q000378:metabolism*; D000075243:Apolipoproteins M; D050197:Atherosclerosis / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism*; D006801:Humans; D054834:Lipocalins
C400523:APOM protein, human; D001053:Apolipoproteins; D000075243:Apolipoproteins M; D054834:Lipocalins