The relative effects of severe burn injury and pre- and post-natal protein deprivation on mandibular condyle morphology.
The mandible has a mixed embryological origin, and its growth is associated with the secondary cartilage of the condyle process (CP). In this area, growth depends on an array of intrinsic and extrinsic factors that influence protein metabolism. In the present study, we used an adolescent rat model to evaluate the growth and development of the CP under conditions of pre- and postnatal protein deficiency, combined with or without the stress of severe burn injury (BI). We found that protein deficiency severely undermined the growth of the CP, by altering the thickness of its constituent layers. BI is also capable of affecting CP growth, although the effect is less severe than protein deficiency. Interestingly, the summed effect of protein deficiency and BI on the CP is less severe than protein deficiency alone. A possible explanation is that the increased carbohydrates in a hypoproteic diet stimulate the production of endogenous insulin and protein synthesis, which partially compensates for the loss of lean body mass caused by BI.
de Oliveira
Bruna Cecília Caixeta
BC
Laboratory of Functional Anatomy Applied to Clinic and Surgery-LAFACC, Departament of Anatomy, Institute of Biomedical Sciences, University of São Paulo, City of São Paulo, State of São Paulo, Brazil. sboldrin@usp.br
de Oliveira
Flávia
F
Martini
Dorival Terra
DT
Prisco
Cleide Rosana Duarte
CR
da Silva Riguetti
Marta Maria
MM
Liberti
Edson Aparecido
EA
de Campos Boldrini
Silvia
S
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight; D002056:Burns / Q000473:pathology*; D002356:Cartilage / Q000473:pathology; D004396:Coloring Agents; D005260:Female; D008297:Male; D008335:Mandibular Condyle / Q000033:anatomy & histology* / Q000473:pathology*; D010619:Phenazines; D011502:Protein-Energy Malnutrition / Q000473:pathology*; D051381:Rats; D016707:Tissue Fixation
D004396:Coloring Agents; D010619:Phenazines; C009195:safranine T