title: Synthesis and biodistribution studies of carbohydrate derivatives radiolabeled with technetium-99m.
abstract: Three carbohydrate derivatives, MAG(3)-Gl, MAG(3)-Ga, MAG(3)-NG, were synthesized and radiolabeled in high yields. These substances were injected in health Swiss mice and their biodistribution were evaluated. Among them, (99m)Tc-MAG(3)-Ga displayed higher accumulation in hepatic tissue, due to the presence of specific receptors in the liver for this carbohydrate. Thus, the use of (99m)Tc-MAG(3)-Ga to assess hepatic function can be considered.
authors.affiliation: Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31279-901 Belo Horizonte, Minas Gerais, Brazil.
authors.forename: André Luís Branco
authors.initials: AL
authors.lastname: de Barros
authors.forename: Valbert Nascimento
authors.initials: VN
authors.lastname: Cardoso
authors.forename: Luciene das Graças
authors.initials: Ld
authors.lastname: Mota
authors.forename: Ricardo José
authors.initials: RJ
authors.lastname: Alves
mesh_terms: D000818:Animals; D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D005998:Glycine / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics; D007553:Isotope Labeling; D008099:Liver / Q000378:metabolism; D051379:Mice; D017263:Technetium Tc 99m Mertiatide / Q000737:chemistry* / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D002241:Carbohydrates; C096273:N-(mercaptoacetyl)glycine; D017263:Technetium Tc 99m Mertiatide; D005998:Glycine