Efficient generation of highly functionalized fused oxazepine frameworks based on a CAN-catalyzed four-component tetrahydropyridine synthesis/ring-closing metathesis sequence.
1-Allyl(propargyl)-6-allyl(propargyl)oxy-1,4,5,6-tetrahydropyridines, obtained through a CAN-catalyzed four-component reaction, were transformed into highly functionalized pyrido[2,1-b][1,3]oxazepines by ring-closing metathesis (RCM) and ring-closing enyne metathesis (RCEYM) processes, which constitute the first examples of the preparation of 1,3-oxazepine systems using metathesis reactions.
Sridharan
Vellaisamy
V
Departamento de Química Orgánica y Farmacéutica,Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
Maiti
Swarupananda
S
Menéndez
J Carlos
JC
D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D002563:Cerium / Q000737:chemistry*; D003500:Cyclization; D018716:Molecular Mimicry; D009566:Nitrates / Q000737:chemistry*; D010077:Oxazepines / Q000138:chemical synthesis* / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*
D000480:Alkynes; D009566:Nitrates; D010077:Oxazepines; D011725:Pyridines; C532772:cerium(IV) ammonium nitrate; D002563:Cerium