title: The concept of induced membrane for reconstruction of long bone defects.
abstract: Clinical, experimental, and fundamental studies have shown the interest of a foreign body-induced membrane to promote the consolidation of a conventional cancellous bone autograft for reconstruction of long bone defects. The main properties of the membrane are to prevent the resorption of the graft and to secrete growth factors. The induced membrane appears as a biological chamber, which allows the conception of numerous experimental models of bone reconstruction. This concept could probably be extended to other tissue repair.
authors.affiliation: Department of Orthopedic and Traumatology, Avicenne Hospital, Medical University of Paris, 125, route de Stalingrad, 93009 Bobigny, Paris, France. alain-charles.masquelet@avc.aphp.fr
authors.forename: Alain C
authors.initials: AC
authors.lastname: Masquelet
authors.forename: Thierry
authors.initials: T
authors.lastname: Begue
mesh_terms: D000818:Animals; D016025:Bone Transplantation / Q000379:methods*; D018483:Diaphyses / Q000293:injuries / Q000601:surgery; D017102:Fracture Healing; D005599:Fractures, Ununited / Q000601:surgery*; D006801:Humans; D008567:Membranes, Artificial; D019651:Plastic Surgery Procedures / Q000379:methods*
chemical_list: D008567:Membranes, Artificial