Bidirectional plasticity in fast-spiking GABA circuits by visual experience.
Experience-dependent plasticity in the brain requires balanced excitation-inhibition. How individual circuit elements contribute to plasticity outcome in complex neocortical networks remains unknown. Here we report an intracellular analysis of ocular dominance plasticity-the loss of acuity and cortical responsiveness for an eye deprived of vision in early life. Unlike the typical progressive loss of pyramidal-cell bias, direct recording from fast-spiking cells in vivo reveals a counterintuitive initial shift towards the occluded eye followed by a late preference for the open eye, consistent with a spike-timing-dependent plasticity rule for these inhibitory neurons. Intracellular pharmacology confirms a dynamic switch of GABA (gamma-aminobutyric acid) impact to pyramidal cells following deprivation in juvenile mice only. Together these results suggest that the bidirectional recruitment of an initially binocular GABA circuit may contribute to experience-dependent plasticity in the developing visual cortex.
Yazaki-Sugiyama
Yoko
Y
CREST, JST, Toyonaka, Osaka 560-0082, Japan.
Kang
Siu
S
Câteau
Hideyuki
H
Fukai
Tomoki
T
Hensch
Takao K
TK
D000200:Action Potentials / Q000502:physiology*; D000375:Aging / Q000502:physiology; D000818:Animals; D023882:Dominance, Ocular / Q000502:physiology*; D007395:Interneurons / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008959:Models, Neurological; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000378:metabolism*; D010775:Photic Stimulation; D017966:Pyramidal Cells / Q000378:metabolism; D018079:Receptors, GABA / Q000378:metabolism; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology; D014795:Visual Pathways / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D018079:Receptors, GABA; D005680:gamma-Aminobutyric Acid