The heart in rheumatoid arthritis.
Morbidity and mortality rates are higher in rheumatoid arthritis (RA) patients than in the general population. Many studies have shown that coronary artery disease is one of the most common causes of death in RA and seems to occur at a younger age than in the general population. RA per se is as much a cardiovascular (CV) risk factor as diabetes, arterial hypertension and dyslipidemia etc., and so it is necessary to plan a follow-up using the same diagnostic and therapeutic approaches as those commonly used for primary and secondary prevention in non-RA patients at high CV risk. All of the cardiac structures can be affected during the course of RA (valves, the conduction system, the myocardium, endocardium and pericardium, and the coronary arteries), and cardiac complications include a variety of clinical manifestations. As these are all associated with an unfavourable prognosis, it is essential to detect subclinical cardiac involvement in still asymptomatic RA patients in order to assure adequate long-term treatment.
Turiel
Maurizio
M
Cardiology Unit, Dipartimento di Tecnologie per la Salute, IRCCS Orthopedic Galeazzi Institute, University of Milan, Milan, Italy. maurizio.turiel@unimi.it
Sitia
Simona
S
Atzeni
Fabiola
F
Tomasoni
Livio
L
Gianturco
Luigi
L
Giuffrida
Matteo
M
De Gennaro Colonna
Vito
V
Sarzi-Puttini
Piercarlo
P
D000367:Age Factors; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology / Q000401:mortality / Q000503:physiopathology; D002423:Cause of Death; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology / Q000401:mortality / Q000503:physiopathology; D003326:Coronary Circulation / Q000276:immunology; D042241:Early Diagnosis; D004452:Echocardiography; D004730:Endothelium, Vascular / Q000276:immunology*; D006801:Humans; D011379:Prognosis; D012307:Risk Factors