title: Rotavirus infection in hospitalized children and estimates of disease burden in Kyrgyzstan, 2005-2007.
abstract: To estimate the rotavirus-associated burden in Kyrgyzstan, we conducted hospital surveillance among children <5 years old with diarrhoea during 2005-2007. Of 3756 children hospitalized with diarrhoea, 26% had rotavirus detected in stool samples by an enzyme immunoassay. The virus genotype G1P[8] was identified in 60% of 190 characterized samples from 2005 to 2006. The estimated risk for rotavirus hospitalization by age 5 years was 1 in 28 children. One quarter of all gastroenteritis hospitalizations in children <5 years old in Kyrgyzstan may be attributable to rotavirus. Rotavirus vaccination could be an important health intervention to reduce the burden of rotavirus gastroenteritis.
authors.affiliation: Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway. elmira.flem@fhi.no
authors.forename: Elmira T
authors.initials: ET
authors.lastname: Flem
authors.forename: Kaliya T
authors.initials: KT
authors.lastname: Kasymbekova
authors.forename: Kirsti
authors.initials: K
authors.lastname: Vainio
authors.forename: Jon
authors.initials: J
authors.lastname: Gentsch
authors.forename: Sabirjan T
authors.initials: ST
authors.lastname: Abdikarimov
authors.forename: Roger I
authors.initials: RI
authors.lastname: Glass
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Bresee
mesh_terms: D002673:Child, Hospitalized / Q000706:statistics & numerical data*; D002675:Child, Preschool; D017281:Cost of Illness; D003967:Diarrhea / Q000453:epidemiology / Q000821:virology; D005243:Feces / Q000821:virology; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology; D005838:Genotype; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007707:Kyrgyzstan / Q000453:epidemiology; D018570:Risk Assessment; D012401:Rotavirus / Q000235:genetics / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000453:epidemiology*; D018571:Sentinel Surveillance