Erythrocyte binding ligands in malaria parasites: intracellular trafficking and parasite virulence.
The intracellular trafficking of an Erythrocyte Binding Like (EBL) ligand has recently been shown to dramatically affect the multiplication rate and virulence of the rodent malaria parasite Plasmodium yoelii yoelii. In this review, we describe the current understanding of the role of EBL and other erythrocyte binding ligands in erythrocyte invasion, and discuss the mechanisms by which they may control multiplication rates and virulence in malaria parasites.
Culleton
Richard
R
Department of Protozoology, Institute of Tropical Medicine and the Global Center of Excellence Program, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Japan.
Kaneko
Osamu
O
D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000502:physiology*; D004912:Erythrocytes / Q000469:parasitology*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010961:Plasmodium / Q000254:growth & development / Q000472:pathogenicity*; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D015800:Protozoan Proteins / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D014774:Virulence; D037521:Virulence Factors / Q000502:physiology*
D000953:Antigens, Protozoan; C066001:Duffy antigen binding protein, Plasmodium; D015800:Protozoan Proteins; D011956:Receptors, Cell Surface; D037521:Virulence Factors