Hyperhomocysteinemia-induced Dyrk1a downregulation results in cardiomyocyte hypertrophy in rats.
Cardiac hypertrophy has been demonstrated in rat models of hyperhomocysteinemia, a major risk factor for chronic heart failure. As one of the molecular pathway which leads to cardiac hypertrophy is mediated by the serine-threonine kinase DYRK1A, we have determined the expression of Dyrk1a in the heart of hyperhomocysteinemic rats and found that hyperhomocysteinemia in rats not only induced ventricular cardiomyocyte hypertrophy but also decreased protein Dyrk1a expression. The decreased expression of Dyrk1a could be consistent with decreased antihypertrophic effects of Dyrk1a leading to cardiomyocyte hypertrophy in case of hyperhomocysteinemia.
Raaf
Lamia
L
University Paris Diderot-CNRS EAC 4413, Unit of Functional and Adaptive Biology (BFA), Paris, France; Laboratory of Biochemistry and Extracellular Matrix Remodeling, BCM.FSB.USTHB, Algiers, Algeria.
Noll
Christophe
C
University Paris Diderot-CNRS EAC 4413, Unit of Functional and Adaptive Biology (BFA), Paris, France.
Cherifi
Mohamed
M
Laboratory of Biochemistry, Hôpital Parnet, Algiers, Algeria.
Benazzoug
Yasmina
Y
Laboratory of Biochemistry and Extracellular Matrix Remodeling, BCM.FSB.USTHB, Algiers, Algeria.
Delabar
Jean-Maurice
JM
University Paris Diderot-CNRS EAC 4413, Unit of Functional and Adaptive Biology (BFA), Paris, France.
Janel
Nathalie
N
University Paris Diderot-CNRS EAC 4413, Unit of Functional and Adaptive Biology (BFA), Paris, France. Electronic address: nathalie.janel@univ-paris-diderot.fr.
D000818:Animals; D006332:Cardiomegaly / Q000201:enzymology* / Q000209:etiology / Q000473:pathology; D015536:Down-Regulation / Q000502:physiology*; D020138:Hyperhomocysteinemia / Q000150:complications / Q000201:enzymology* / Q000473:pathology; D032383:Myocytes, Cardiac / Q000201:enzymology* / Q000473:pathology*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D051381:Rats; D000097603:Dyrk Kinases
D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D000097603:Dyrk Kinases