Math1: waiting to inhale.
The proneural gene Math1 is known to be involved in numerous functions within the nervous system, including unconscious proprioception, audition, and arousal. Two recent papers by the Zoghbi group in this issue of Neuron and a recent issue of PNAS now identify a critical role for this gene in the development of brainstem regions critical for conscious proprioception, interoception, and respiration.
Machold
Robert P
RP
Smilow Neuroscience Program, Smilow Research Center, New York University School of Medicine, New York, NY 10016, USA. robert.machold@med.nyu.edu
Fishell
Gord
G
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics* / Q000378:metabolism*; D001933:Brain Stem / Q000196:embryology / Q000254:growth & development* / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism; D008526:Medulla Oblongata / Q000196:embryology / Q000254:growth & development / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D009434:Neural Pathways / Q000196:embryology / Q000254:growth & development / Q000502:physiology; D009474:Neurons / Q000502:physiology; D010507:Periodicity; D012119:Respiration / Q000235:genetics*
D051792:Basic Helix-Loop-Helix Proteins; D018698:Glutamic Acid; C500943:Atoh1 protein, mouse