title: Physiological aging in older adults with cancer: implications for treatment decision making and toxicity management.
abstract: Because the risk of cancer increases with age, the growth of the aging population will lead to a larger number of older adults with cancer. Standard cancer treatments can be safe and effective in older adults and result in improved survival and enhanced quality of life. Because physiological decline varies among older adults, cancer treatment requires an individualized approach. Consideration of physiological age, rather than chronological age alone, is required to guide treatment decision making and prevent and manage treatment toxicities and other complications. This article examines the impact of physiological aging on treatment decision making and toxicity management in older adults with cancer.
authors.affiliation: Vanderbilt University School of Nursing, Nashville, Tennessee 37240, USA. stewart.m.bond@vanderbilt.edu
authors.forename: Stewart M
authors.initials: SM
authors.lastname: Bond
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000378:metabolism / Q000493:pharmacokinetics; D001855:Bone Marrow Diseases / Q000139:chemically induced; D003657:Decision Making; D015577:Geriatric Assessment / Q000379:methods*; D006331:Heart Diseases / Q000139:chemically induced; D006801:Humans; D009140:Musculoskeletal Diseases / Q000139:chemically induced; D009369:Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000378:metabolism; D009422:Nervous System Diseases / Q000139:chemically induced; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D017751:Safety Management; D013280:Stomatitis / Q000139:chemically induced; D014481:United States / Q000453:epidemiology
chemical_list: D000970:Antineoplastic Agents