[Use of dietary phenols to modulate inflammatory bowel response].
Crohn's disease and ulcerative colitis are two forms of inflammatory bowel disease (IBD). Genetic and environmental factors influencing the onset and course of this disease have recently been identified. Among the environmental and dietary factors involved in the development of inflammatory colon diseases, dietary polyphenols have been proposed as protective agents in distinct models of colon inflammation. However, despite the huge number of studies on the beneficial effects of polyphenols on health, their dietary effectiveness is unclear. In this review, we examine some of the evidence linking dietary polyphenol intake with protection against IBD.
Frontela
Carmen
C
Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione (INRAN), Roma, Italia. carmenfr@um.es
Canali
Raffaella
R
Virgili
Fabio
F
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D018928:Immunity, Mucosal / Q000187:drug effects; D015212:Inflammatory Bowel Diseases / Q000178:diet therapy* / Q000235:genetics / Q000276:immunology / Q000517:prevention & control; D015227:Lipid Peroxidation / Q000187:drug effects; D054647:Nutrigenomics; D018384:Oxidative Stress / Q000187:drug effects; D010636:Phenols / Q000494:pharmacology / Q000627:therapeutic use*; D059808:Polyphenols; D017382:Reactive Oxygen Species
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D017382:Reactive Oxygen Species