The effect of heme oxygenase inhibition on visual evoked potentials.
This study investigated the effect of heme oxygenase (HO) inhibition on visual evoked potentials (VEPs). HO catalyzes the oxidative degradation of heme. Products of HO reaction are biliverdin, ferrous iron, and carbon monoxide (CO). CO is a signal molecule and is an endogenous modulator in the soluble guanylate cyclase/cyclic guanosine monophosphate signaling pathway. Rats were treated with HO inhibitors tin protoporphyrin IX (SnPP IX) or zinc protoporphyrin IX (ZnPP IX) or HO inducer sodium arsenite (Na-arsenite). Soluble guanylate cyclase is inhibited by 1H-[1,2,3]oxydiazolo[4,3-a]quinoxalin-1-one (ODQ) and induced by 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1). VEPs were recorded under mild ether anesthesia with the help of stainless steel subdermal electrodes and a photic stimulator. SnPP IX, ODQ or SnPP IX + YC-1 injections significantly prolonged latencies of P3; however, Na-arsenite shortened latency of P3. It has been shown that HO affects VEPs.
Savcioglu
Feyza
F
Department of Physiology, Institute of Health Sciences, Akdeniz University, School of Medicine, Antalya, Turkey. feyza@akdeniz.edu.tr
Akpinar
Deniz
D
Yargicoglu
Piraye
P
Agar
Aysel
A
D000818:Animals; D018053:Arsenites / Q000494:pharmacology; D020536:Enzyme Activators / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D006419:Heme Oxygenase (Decyclizing) / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D007191:Indazoles / Q000494:pharmacology; D008297:Male; D008665:Metalloporphyrins / Q000494:pharmacology; D010069:Oxadiazoles / Q000494:pharmacology; D011524:Protoporphyrins / Q000494:pharmacology; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017670:Sodium Compounds / Q000494:pharmacology; D014795:Visual Pathways / Q000187:drug effects
C095284:1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one; D018053:Arsenites; D020536:Enzyme Activators; D004791:Enzyme Inhibitors; D007191:Indazoles; D008665:Metalloporphyrins; D010069:Oxadiazoles; D011524:Protoporphyrins; D011810:Quinoxalines; D017670:Sodium Compounds; C017803:zinc protoporphyrin; C090937:3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole; C017947:sodium arsenite; C032628:tin protoporphyrin IX; D006419:Heme Oxygenase (Decyclizing)