Molecular interaction of Siglecs (sialic acid-binding Ig-like lectins) with sialylated ligands on Trypanosoma cruzi.
The protozoan parasite Trypanosoma cruzi (T. cruzi) is transmitted by blood-sucking insect vectors. After transmission, parasites circulate in the blood as trypomastigotes and invade a variety of cells to multiply intracellularly as amastigotes. The acute phase triggers an immune response that restricts the dissemination and proliferation of parasites. However, parasites are able to persist in different tissues for decades causing the pathology of Chagas' disease. T. cruzi expresses a trans-sialidase (TS). This unique enzyme transfers sialic acid from host glycoconjugates to mucin-like molecules on the parasite and is supposed to be a major virulence factor. TS and sialylated structures were implicated in the persistence of parasites. We discuss here the recent findings on the function of sialylated structures on the surface of T. cruzi with a special emphasis on their property to interact with sialic acid-binding Ig-like lectins, which may allow the parasite to modulate the immune system of the host.
Jacobs
Thomas
T
Department of Immunology, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany. tjacobs@bni.uni-hamburg.de
Erdmann
Hanna
H
Fleischer
Bernhard
B
D000818:Animals; D006001:Glycoconjugates / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D037102:Lectins / Q000276:immunology / Q000378:metabolism*; D008024:Ligands; D019158:N-Acetylneuraminic Acid / Q000378:metabolism*; D009439:Neuraminidase / Q000378:metabolism; D010271:Parasites / Q000201:enzymology; D063265:Sialic Acid Binding Immunoglobulin-like Lectins; D014349:Trypanosoma cruzi / Q000201:enzymology / Q000378:metabolism*
D006001:Glycoconjugates; D006023:Glycoproteins; D037102:Lectins; D008024:Ligands; D063265:Sialic Acid Binding Immunoglobulin-like Lectins; C069715:trans-sialidase; D009439:Neuraminidase; D019158:N-Acetylneuraminic Acid