Caged ceramide 1-phosphate analogues: synthesis and properties.
Sphingolipid phosphate analogues bearing 7-(diethylamino)coumarin (DECM) and 4-bromo-5-hydroxy-2-nitrobenzhydryl (BHNB) groups in a photolabile ester bond were synthesized. The ability of the "caged" ceramide 1-phosphate analogues to release the bioactive parent molecule upon irradiation at 400-500 nm was demonstrated by stimulation of macrophage cell proliferation.
Lankalapalli
Ravi S
RS
Department of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, New York 11367-1597, USA.
Ouro
Alberto
A
Arana
Lide
L
Gómez-Muñoz
Antonio
A
Bittman
Robert
R
D002518:Ceramides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D002518:Ceramides; C065576:ceramide 1-phosphate