Long-term disease-free survivor of metastatic large-cell neuroendocrine carcinoma of the lung treated with amrubicin and irinotecan.
Large-cell neuroendocrine carcinoma (LCNEC) is a relatively uncommon variant of non-small cell lung cancer. Since the biological characteristics of LCNEC are similar to those of small cell lung cancer, LCNEC is usually treated with chemotherapy regimens used for small cell lung cancer. However, the outcomes are usually dismal. Here, we report a patient with LCNEC (a metastasis to the brain). After whole brain irradiation, he received a combination of amrubicin and irinotecan chemotherapy, and has been relapse-free for two years. This treatment regimen may be beneficial for patients with advanced LCNEC.
Ryuge
Shinichiro
S
Department of Respiratory Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa, Japan.
Jiang
Shi-Xu
SX
Wada
Mayuko
M
Katono
Ken
K
Iwasaki
Maiko
M
Takakura
Akira
A
Otani
Sakiko
S
Kimura
Yuka
Y
Fukui
Tomoya
T
Yokoba
Masanori
M
Kubota
Masaru
M
Katagiri
Masato
M
Hayakawa
Kazusige
K
Masuda
Noriyuki
N