title: Hyperhomocysteinemia-induced Dyrk1a downregulation results in cardiomyocyte hypertrophy in rats.
abstract: Cardiac hypertrophy has been demonstrated in rat models of hyperhomocysteinemia, a major risk factor for chronic heart failure. As one of the molecular pathway which leads to cardiac hypertrophy is mediated by the serine-threonine kinase DYRK1A, we have determined the expression of Dyrk1a in the heart of hyperhomocysteinemic rats and found that hyperhomocysteinemia in rats not only induced ventricular cardiomyocyte hypertrophy but also decreased protein Dyrk1a expression. The decreased expression of Dyrk1a could be consistent with decreased antihypertrophic effects of Dyrk1a leading to cardiomyocyte hypertrophy in case of hyperhomocysteinemia.
authors.affiliation: University Paris Diderot-CNRS EAC 4413, Unit of Functional and Adaptive Biology (BFA), Paris, France; Laboratory of Biochemistry and Extracellular Matrix Remodeling, BCM.FSB.USTHB, Algiers, Algeria.
authors.forename: Lamia
authors.initials: L
authors.lastname: Raaf
authors.affiliation: University Paris Diderot-CNRS EAC 4413, Unit of Functional and Adaptive Biology (BFA), Paris, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Noll
authors.affiliation: Laboratory of Biochemistry, Hôpital Parnet, Algiers, Algeria.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Cherifi
authors.affiliation: Laboratory of Biochemistry and Extracellular Matrix Remodeling, BCM.FSB.USTHB, Algiers, Algeria.
authors.forename: Yasmina
authors.initials: Y
authors.lastname: Benazzoug
authors.affiliation: University Paris Diderot-CNRS EAC 4413, Unit of Functional and Adaptive Biology (BFA), Paris, France.
authors.forename: Jean-Maurice
authors.initials: JM
authors.lastname: Delabar
authors.affiliation: University Paris Diderot-CNRS EAC 4413, Unit of Functional and Adaptive Biology (BFA), Paris, France. Electronic address: nathalie.janel@univ-paris-diderot.fr.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Janel
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000201:enzymology* / Q000209:etiology / Q000473:pathology; D015536:Down-Regulation / Q000502:physiology*; D020138:Hyperhomocysteinemia / Q000150:complications / Q000201:enzymology* / Q000473:pathology; D032383:Myocytes, Cardiac / Q000201:enzymology* / Q000473:pathology*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D051381:Rats; D000097603:Dyrk Kinases
chemical_list: D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D000097603:Dyrk Kinases