title: Effects of birth weight on anti-mullerian hormone serum concentrations in infant girls.
abstract: BACKGROUND
  We previously demonstrated that low birth weight (BW) infant girls show increased serum anti-Müllerian hormone (AMH) concentrations and poststimulated estradiol levels compared to normal-BW infants, suggesting an altered follicular development. However, the impact of high BW on reproductive function is less known.
  
  
  OBJECTIVE
  To evaluate the effect of BW on AMH, we determined the concentrations of this hormone in low-BW, normal-BW, and high-BW female infants during the first 3 months of life.
  
  
  METHODS
  Twenty-seven low-BW, 29 normal-BW, and 28 high-BW infant girls were studied. We measured serum gonadotropins, steroid hormones, AMH, glucose, insulin, free fatty acids, IGF-I, and adiponectin in a fasting blood sample. In addition, in a subgroup of normal-BW (n = 23) and high-BW infants (n = 10), a GnRH analog leuprolide acetate test was performed.
  
  
  RESULTS
  Serum concentrations of AMH were higher in low-BW and high-BW infants compared to normal-BW infants (P = 0.028 and 0.022, respectively). In addition, in high-BW infants, adiponectin concentrations were lower (P = 0.018), and poststimulated FSH and estradiol levels were higher compared to normal-BW infants (P = 0.024 and 0.047, respectively).
  
  
  CONCLUSIONS
  Serum AMH and poststimulated estradiol concentrations are increased in low-BW and high-BW female infants, suggesting that these girls may show evidence of an altered follicular development. However, the increased poststimulated FSH levels and low adiponectin concentrations observed in high-BW infants suggest that ovarian function is perturbed through a different mechanism from that in low-BW infants.
authors.affiliation: Laboratory of Endocrinology, Department of Medicine, West Division, School of Medicine, Las Palmeras 299, Interior Quinta Normal, Casilla 33052, Correo 33, Santiago, Chile. tsir@med.uchile.cl
authors.forename: Teresa
authors.initials: T
authors.lastname: Sir-Petermann
authors.forename: Lorena
authors.initials: L
authors.lastname: Márquez
authors.forename: Michael
authors.initials: M
authors.lastname: Cárcamo
authors.forename: Catalina
authors.initials: C
authors.lastname: Hitschfeld
authors.forename: Ethel
authors.initials: E
authors.lastname: Codner
authors.forename: Manuel
authors.initials: M
authors.lastname: Maliqueo
authors.forename: Bárbara
authors.initials: B
authors.lastname: Echiburú
authors.forename: Pablo
authors.initials: P
authors.lastname: Aranda
authors.forename: Nicolás
authors.initials: N
authors.lastname: Crisosto
authors.forename: Fernando
authors.initials: F
authors.lastname: Cassorla
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D001724:Birth Weight; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D020738:Leptin / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000150:complications; D011247:Pregnancy
chemical_list: D052242:Adiponectin; D020738:Leptin; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone