title: [Methodological approaches to the experimental investigation of dermotropic drugs].
abstract: Methodological approaches to preclinical evaluation of the efficiency of potential dermotropic preparations are proposed on the basis of original investigations and an analysis of published data. At the first stage of the preclinical investigation of preparations for external application, it is necessary to estimate their acute toxicity, allergenic activity, and local irritation effect in addition to studying the specific activity.
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Frolova
authors.forename: T I
authors.initials: TI
authors.lastname: Mel'nikova
authors.forename: A V
authors.initials: AV
authors.lastname: Buriakina
authors.forename: E K
authors.initials: EK
authors.lastname: Vishnevskaia
authors.forename: E L
authors.initials: EL
authors.lastname: Avenirova
authors.forename: K V
authors.initials: KV
authors.lastname: Sivak
authors.forename: A V
authors.initials: AV
authors.lastname: Karavaeva
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D012871:Skin Diseases / Q000188:drug therapy*