title: Clinical trial of efficacy of ivermectin pour-on against gastrointestinal parasitic nematodes in silvopasturing horses.
abstract: The aim of this study was to assess, by a clinical trial, the efficacy of an ivermectin-based pour-on treatment against gastrointestinal parasitic nematodes in naturally infected horses using 2 groups of mature indigenous Pura Raza Galega grazing mares. Faecal and blood samples were collected individually over a 21 week period. Faeces were analysed by the coprological flotation, sedimentation and migration techniques. Changes in circulating blood cells were monitored over the study period. The administration of the ivermectin suppressed the egg-elimination of ascarids and pinworms throughout the study and no strongyle-eggs were observed in the treatment group between the 3rd and 10th weeks. The numbers of red cells increased significantly after the anthelmintic therapy, and a statistical reduction in circulating leucocytes was recorded. No side effects were observed. The pour-on ivermectin formulation was highly successful against gastrointestinal nematodes and appears to be a useful therapeutic routine for large groups of horses.
authors.affiliation: Animal Pathology Department, Epidemiology, Zoonoses and Parasitic Diseases, Veterinary Faculty, Santiago de Compostela University, Lugo, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Francisco
authors.forename: J A
authors.initials: JA
authors.lastname: Sánchez
authors.forename: F J
authors.initials: FJ
authors.lastname: Cortiñas
authors.forename: R
authors.initials: R
authors.lastname: Francisco
authors.forename: E
authors.initials: E
authors.lastname: Mochales
authors.forename: M
authors.initials: M
authors.lastname: Arias
authors.forename: P
authors.initials: P
authors.lastname: Mula
authors.forename: J L
authors.initials: JL
authors.lastname: Suárez
authors.forename: P
authors.initials: P
authors.lastname: Morrondo
authors.forename: P
authors.initials: P
authors.lastname: Díez-Baños
authors.forename: R
authors.initials: R
authors.lastname: Sánchez-Andrade
authors.forename: A
authors.initials: A
authors.lastname: Paz-Silva
mesh_terms: D000287:Administration, Topical; D000822:Animal Husbandry; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D005243:Feces / Q000469:parasitology; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D010270:Parasite Egg Count; D013997:Time Factors
chemical_list: D000871:Anthelmintics; D007559:Ivermectin