Treatment of atypical central neurocytoma in a child with high dose chemotherapy and autologous stem cell rescue.
The authors describe a 9 month old female with recurrent atypical central neurocytoma and leptomeningeal spread treated with high dose chemotherapy, autologous stem cell rescue, and adjuvant therapy. She had a complete response to therapy and was disease free at 4 years of age until a recurrence 6 months later. The use of intensive chemotherapy followed by autologous stem cell rescue for atypical neurocytoma may be considered as an adjunct to surgical therapy in young patients with atypical neurocytoma not amenable to radiation therapy.
Buchbinder
David
D
Department of Pediatric Hematology, Children's Hospital of Orange County, 455 S Main Street, Orange, CA 92868, USA. dbuchbinder@choc.org
Danielpour
Moise
M
Yong
William H
WH
Salamon
Noriko
N
Lasky
Joseph
J
D001932:Brain Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery*; D018306:Neurocytoma / Q000150:complications / Q000188:drug therapy* / Q000601:surgery*; D014057:Tomography, X-Ray Computed / Q000379:methods