The genetics of cardiovascular disease: new insights from emerging approaches.
The prospect that sequencing the human genome would see rapid translation of a greater understanding of cardiovascular genetics into novel diagnostics and therapeutics has so far met with only limited success. However, diverse technological advances and exploitation of novel animal models of cardiovascular development and disease are providing ever more insight into cardiovascular diseases and development, and bring closer the prospect of 'post-genomic' diagnostics and therapies. Here we review some of these emerging approaches (genome wide association studies, deep sequencing, microRNA regulation, and zebrafish as a model of cardiovascular disease and development) and discuss their potential for finally fulfilling the promise of application to clinical cardiovascular medicine.
Chico
Timothy J A
TJ
MRC Centre for Developmental and Biomedical Genetics, Sheffield, UK. t.j.chico@sheffield.ac.uk
Milo
Marta
M
Crossman
David C
DC
D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics*; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D015027:Zebrafish
D035683:MicroRNAs