Five new C21 steroidal glycosides from the stems of Marsdenia tenacissima.
Five new C(21) steroidal glycosides (1-5) were isolated from the stems of Marsdenia tenacissima. The chemical structures and relative configurations of the new compounds were elucidated by mass spectrometry and NMR spectroscopy. Cellular assay of these compounds showed that they are weak cytotoxic to various cell lines.
Zhang
Hua
H
Jiangsu Simcere Pharmaceutical R&D Co., Ltd., No. 699-18 Xuanwu Avenue, Xuanwu District, Nanjing 210042, PR China. jacal teresa@hotmail.com
Tan
Ai-Min
AM
Zhang
An-Yuan
AY
Chen
Rong
R
Yang
Shi-Bao
SB
Huang
Xing
X
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D031101:Marsdenia / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification*
D000970:Antineoplastic Agents; D006027:Glycosides; D013256:Steroids