Deciphering the molecular basis of venous thromboembolism: where are we and where should we go?
Venous thromboembolism (VTE) is a frequent disease that has a major genetic component of risk. However, known identified genetic risk factors account for <30% of idiopathic (without any environmental origin) VTE cases. This article aims to review the lessons learnt during recent decades in the field of the genetics of VTE, describe the present state-of-art methods and discuss promising themes for finding new susceptibility loci.
Morange
Pierre-Emmanuel
PE
INSERM UMR S626, Faculty of Medicine, University of the Mediterranean, Marseille, France. pmorange@ap-hm.fr
Tregouet
David-Alexandre
DA
D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000235:genetics*