title: Autonomic cardiovascular modulation.
abstract: We validated a symbolic approach to assess autonomic modulation from pulse interval (PI) and systolic arterial pressure (SAP) series obtained from an animal model of chronic heart failure (CHF). We studied three groups of rats: controls; CHF animals; CHF animals treated with spironolactone (CHF-SP), reducing sympathetic activity in CHF. Simulations confirmed that symbolic analysis captures modifications of cardiovascular regulation in the case of fast dynamics and negligible variance. While spectral indexes did not reveal any significant difference among groups, symbolic analysis pointed out that sympathetic modulation is reduced in CHF group and restored to basal values in CHF-SP one.
authors.affiliation: Laboratorio di Modellistica di Sistemi Complessi, Dipartimento di Tecnologie per Salute, Istituto Ortopedico Galeazzi, Università degli Studi di Milano, Via R. Galeazzi 4, 20161 Milan, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Tobaldini
authors.forename: Nicola
authors.initials: N
authors.lastname: Montano
authors.forename: Shun-Guang
authors.initials: SG
authors.lastname: Wei
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Joseph
authors.initials: J
authors.lastname: Francis
authors.forename: Robert M
authors.initials: RM
authors.lastname: Weiss
authors.forename: Karina R
authors.initials: KR
authors.lastname: Casali
authors.forename: Robert B
authors.initials: RB
authors.lastname: Felder
authors.forename: Alberto
authors.initials: A
authors.lastname: Porta
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D002908:Chronic Disease; D003198:Computer Simulation; D004195:Disease Models, Animal; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists; D017711:Nonlinear Dynamics; D011674:Pulse; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D013148:Spironolactone / Q000494:pharmacology; D018709:Statistics, Nonparametric
chemical_list: D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone