Pyrazolo[3,4-d]pyrimidinophanes: convenient synthesis of a new class of cyclophane and X-ray structure of the first representative.
A convenient synthesis of a new class of novel pyrazolo[3,4-d]pyrimidinophanes (four products, 41%), a new class of cyclophane, and X-ray structure of the first dissymmetrical [3.4]pyrazolo[3,4-d]pyrimidinophane (22%) are reported for the first time. The conformation of major syn product 6b is stabilized by weak pi-pi and O...Ar interactions.
Avasthi
Kamlakar
K
Medicinal and Process Chemistry Division and Molecular and Structural Biology Division, Central Drug Research Institute, CSIR, Lucknow 226001, India. kavasthi@rediffmail.com
Ansari
Amantullah
A
Tewari
Ashish K
AK
Kant
Ruchir
R
Maulik
Prakas R
PR
D018360:Crystallography, X-Ray; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D004988:Ethers, Cyclic; D011720:Pyrazoles; D011743:Pyrimidines