title: Phorbaketals A, B, and C, sesterterpenoids with a spiroketal of hydrobenzopyran moiety isolated from the marine sponge Phorbas sp.
abstract: Three new sesterterpenoids, phorbaketals A (1), B (2), and C (3) which have a spiroketal of the hydrobenzopyran moiety, were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral and chemical methods. They exhibited moderate cytotoxicity against human colorectal, hepatoma, and lung cancer cell lines. Furthermore, the cultivation of the bacterial fraction from the sponge afforded compound 1.
authors.affiliation: Department of Oceanography, Kunsan National University, Jeonbuk, 573-701, South Korea. jrrho@kunsan.ac.kr
authors.forename: Jung-Rae
authors.initials: JR
authors.lastname: Rho
authors.forename: Buyng Su
authors.initials: BS
authors.lastname: Hwang
authors.forename: Chung Ja
authors.initials: CJ
authors.lastname: Sim
authors.forename: Seewon
authors.initials: S
authors.lastname: Joung
authors.forename: Hee-Yoon
authors.initials: HY
authors.lastname: Lee
authors.forename: Hyeon-Jin
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D056945:Hep G2 Cells; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D054830:Sesterterpenes; C546752:phorbaketal A; C546753:phorbaketal B