Proteoglycans: master modulators of paracrine fibroblast-carcinoma cell interactions.
Reciprocal interactions between tumor and stromal cells govern carcinoma growth and progression. Signaling functions between these cell types in the tumor microenvironment are largely carried out by secreted growth factors and cytokines. This review discusses how proteoglycans, which are abundantly present in normal and neoplastic tissues, modulate paracrine growth factor signaling events. General principles of proteoglycan involvement in paracrine signaling include stromal induction, core protein processing by proteases and growth factor binding via proteoglycan glycosaminoglycan chains or core protein domains.
Friedl
Andreas
A
Department of Pathology and Laboratory Medicine, 6051 Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Madison, WI 53705-2275, United States. afriedl@wisc.edu
D000818:Animals; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism; D005347:Fibroblasts / Q000473:pathology / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology; D019899:Paracrine Communication / Q000502:physiology*; D011509:Proteoglycans / Q000737:chemistry / Q000378:metabolism*; D017154:Stromal Cells / Q000473:pathology / Q000502:physiology*
D036341:Intercellular Signaling Peptides and Proteins; D011509:Proteoglycans