title: Angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers after renal transplantation.
abstract: Renin-angiotensin system blockade retards the progression of diabetic and non-diabetic chronic kidney disease of the native kidneys. Though most patients suffer from a significant renal insufficiency (chronic kidney disease stage III) and a concomitant heart disease after renal transplantation, there is up to now no evidence supporting the use of inhibitors of the renin-angiotensin system in these patients. We wish to summarize the available evidence on the use of inhibitors of the renin-angiotensin system after renal transplantation. We specifically discuss potential beneficial as well as adverse effects of a renin-angiotensin system blockade. In addition, we review their influence on morphologic and biochemical markers as well as on renal function, graft and patient survival after renal transplantation.
authors.affiliation: Department of Nephrology, University of Heidelberg, Heidelberg, Germany. christian.morath@med.uni-heidelberg.de
authors.forename: C
authors.initials: C
authors.lastname: Morath
authors.forename: B
authors.initials: B
authors.lastname: Schmied
authors.forename: A
authors.initials: A
authors.lastname: Mehrabi
authors.forename: J
authors.initials: J
authors.lastname: Weitz
authors.forename: J
authors.initials: J
authors.lastname: Schmidt
authors.forename: J
authors.initials: J
authors.lastname: Werner
authors.forename: M W
authors.initials: MW
authors.lastname: Buchler
authors.forename: M
authors.initials: M
authors.lastname: Morcos
authors.forename: P P
authors.initials: PP
authors.lastname: Nawroth
authors.forename: V
authors.initials: V
authors.lastname: Schwenger
authors.forename: B
authors.initials: B
authors.lastname: Doehler
authors.forename: G
authors.initials: G
authors.lastname: Opelz
authors.forename: M
authors.initials: M
authors.lastname: Zeier
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D006085:Graft Survival; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D016030:Kidney Transplantation; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors