title: Identification of Western equine encephalitis virus structural proteins that confer protection after DNA vaccination.
abstract: DNA vaccines encoding different portions of the structural proteins of western equine encephalitis virus were tested for the efficacy of their protection in a 100% lethal mouse model of the virus. The 6K-E1 structural protein encoded by the DNA vaccine conferred complete protection against challenge with the homologous strain and limited protection against challenge with a heterologous strain.
authors.affiliation: Biological Countermeasures, Human Protection and Performance Division, Defence Science & Technology Organisation, 506 Lorimer St., Fishermans Bend, VIC 3207, Australia. Penny.Gauci@dsto.defence.gov.au
authors.forename: Penelope J
authors.initials: PJ
authors.lastname: Gauci
authors.forename: Josh Q H
authors.initials: JQ
authors.lastname: Wu
authors.forename: George A
authors.initials: GA
authors.lastname: Rayner
authors.forename: Nicole D
authors.initials: ND
authors.lastname: Barabé
authors.forename: Leslie P
authors.initials: LP
authors.lastname: Nagata
authors.forename: David F
authors.initials: DF
authors.lastname: Proll
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D004667:Encephalitis Virus, Western Equine / Q000235:genetics / Q000276:immunology*; D004683:Encephalomyelitis, Equine / Q000517:prevention & control*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D016019:Survival Analysis; D019444:Vaccines, DNA / Q000276:immunology*; D015678:Viral Structural Proteins / Q000235:genetics / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D019444:Vaccines, DNA; D015678:Viral Structural Proteins; D014765:Viral Vaccines