Toxicity of bisphosphonates.
Bisphosphonates have become an important treatment for the palliation of metastatic bone disease. Their increasing use has lead to the recognition of toxicities that can lead to substantial morbidity for the patient with advanced cancer. This case presentation highlights toxicities associated with bisphosphonate use and provides some guidelines on the use of bisphosphonates and management of these toxicities.
Prommer
Eric E
EE
Division of Hematology and Oncology, Mayo Clinic, Scottsdale, Arizona 85259, USA. prommer.eric@mayo.edu
D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000506:poisoning* / Q000627:therapeutic use; D017850:Economics, Pharmaceutical; D006801:Humans; D007568:Jaw / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010020:Osteonecrosis / Q000188:drug therapy; D010166:Palliative Care
D004164:Diphosphonates