[Synthesis of cationic lipid transfection agents with O,O- or N,O-acetal bonds].
The synthesis of cationic lipids on the basis of 1,2-di-O-tetradecylglycerol is described. The cationic groups represented by the residues of nitrogen-containing heterocyclic bases are attached to the diglyceride backbone through O,O- and N,O-acetal bonds. The resulting lipids can be used as nonviral gene delivery systems to eukaryotic cells.
Maslov
M A
MA
Lomonosov State Academy of Fine Chemical Technology, Moscow, Russia. mamaslov@mail.ru
Morozova
N G
NG
Senan
I M
IM
Serebrennikova
G A
GA
D002412:Cations; D004075:Diglycerides / Q000138:chemical synthesis* / Q000737:chemistry*; D014162:Transfection
D002412:Cations; D004075:Diglycerides; C057475:1,2-ditetradecylglycerol