Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.
The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed.
Beseda
Igor
I
Inst. Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, Vienna 1060, Austria.
Czollner
Laszlo
L
Shah
Priti S
PS
Khunt
Rupesh
R
Gaware
Rawindra
R
Kosma
Paul
P
Stanetty
Christian
C
Del Ruiz-Ruiz
Maria Carmen
MC
Amer
Hassan
H
Mereiter
Kurt
K
Da Cunha
Thierry
T
Odermatt
Alex
A
Classen-Houben
Dirk
D
Jordis
Ulrich
U
D042842:11-beta-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D018360:Crystallography, X-Ray; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D008659:Metabolic Diseases / Q000188:drug therapy*; D008958:Models, Molecular
D042842:11-beta-Hydroxysteroid Dehydrogenases; D006034:Glycyrrhetinic Acid