Interpolyelectrolyte complexes of Eudragit E PO with sodium alginate as potential carriers for colonic drug delivery: monitoring of structural transformation and composition changes during swellability and release evaluating.
BACKGROUND
With a view to the application in oral colon drug delivery systems, swelling and release behavior of synthesized interpolyelectrolyte complexes (IPEC) between sodium alginate and Eudragit EPO were investigated.


METHODS
The microenvironmental changes in IPECs structure as a function of pH during swellability testing were investigated using FT-IR spectroscopy and elementary analysis.


RESULTS
All samples of IPECs (Z = 0.66-1.25) during swelling were transformed to a similar structure with approximately the same composition. The release of the model drug diclofenac sodium was significantly delayed from matrices made up of the IPECs and independent from the composition of polycomplexes.


CONCLUSIONS
According to the obtained results, these IPECs can be considered to have potential in colonic drug delivery as combined pH- and time-dependent systems.
Moustafine
Rouslan I
RI
Department of Pharmaceutical, Toxicological and Analytical Chemistry, State Medical University of Kazan, Kazan, Russian Federation. mustaf@rambler.ru
Salachova
Albina R
AR
Frolova
Ekaterina S
ES
Kemenova
Vera A
VA
Van den Mooter
Guy
G
D000464:Alginates / Q000737:chemistry*; D003106:Colon / Q000378:metabolism*; D004008:Diclofenac / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D004573:Electrolytes / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D008968:Molecular Conformation; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets; D013997:Time Factors; D014867:Water / Q000032:analysis
D000464:Alginates; D004337:Drug Carriers; D004573:Electrolytes; D006603:Hexuronic Acids; D011109:Polymethacrylic Acids; D013607:Tablets; D014867:Water; D004008:Diclofenac; D020723:Glucuronic Acid; C518398:Eudragit E PO