Free radical scavenging abilities of flavonyl-thiazolidine-2,4-dione compounds.
Free radical scavenging activity of flavonyl-thiazolidine-2,4-dione compounds has been evaluated using chemiluminescence, electron spin resonance spectroscopy with 5,5-dimethyl-1-pyrroline-1-oxide as spin trap and DPPH (2,2'-diphenyl-1-picrylhydrazyl) method. The examined compounds exhibited 28-50% scavenging superoxide anion radical O₂⁻ⁱ16.7-76.7% hydroxyl radical (HO•) and 9-40% DPPH radical. Compounds containing carbonyl group in their structure can be considered as antioxidants with high relevance and great biological importance.
Bozdağ-Dündar
Oya
O
Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Tandoğan, Ankara, Turkey.
Ertan
Rahmiye
R
Aboul-Enein
Hassan Y
HY
Kładna
Aleksandra
A
Kruk
Irena
I
D047309:Flavones / Q000737:chemistry*; D016166:Free Radical Scavengers; D049449:Luminescence; D015394:Molecular Structure; D045162:Thiazolidinediones / Q000737:chemistry*
D047309:Flavones; D016166:Free Radical Scavengers; D045162:Thiazolidinediones; C500090:thiazolidine-2,4-dione