Unusual onset of venous thromboembolism and heparin-induced thrombocytopenia in a patient with essential thrombocythemia.
Essential thrombocythemia is a hematological disorder characterized by clonal hemopoiesis in the bone marrow and increased number of circulating platelets. It is usually discovered accidentally at the time of routine blood examinations or can become clinically evident with either thrombotic or hemorrhagic complications. In the present article, we describe the case of a 66-year-old woman with pneumonia due to Pneumocystis carinii, who experienced deep vein thrombosis and pulmonary embolism during hospitalization with a subsequent heparin-induced thrombocytopenia. Bone marrow examination performed after clinical improvement revealed the patient to be affected by essential thrombocythemia.
Lapecorella
Mario
M
Centro Emofilia e Trombosi, Unità Operativa Medicina Interna 2, Ematologia, Università de L'Aquila, Ospedale San Salvatore, L'Aquila, Italy. emofilia.aq@cc.univaq.it
Lucchesi
Alessandro
A
Di Ianni
Mauro
M
Napolitano
Mariasanta
M
Coletti
Gino
G
Di Leonardo
Gabriella
G
Dell'Orso
Luigi
L
Barnabei
Remo
R
Mariani
Guglielmo
G
D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D000077425:Fondaparinux; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D033162:Incidental Findings; D010978:Platelet Factor 4 / Q000276:immunology; D011020:Pneumonia, Pneumocystis / Q000150:complications; D011134:Polysaccharides / Q000627:therapeutic use; D011655:Pulmonary Embolism / Q000188:drug therapy / Q000209:etiology*; D013920:Thrombocythemia, Essential / Q000150:complications / Q000175:diagnosis*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology; D013924:Thrombophlebitis / Q000188:drug therapy / Q000209:etiology*; D014859:Warfarin / Q000627:therapeutic use
D000925:Anticoagulants; D011134:Polysaccharides; D010978:Platelet Factor 4; D014859:Warfarin; D006493:Heparin; D000077425:Fondaparinux