4-Fluoro-2,4-methanoproline.
The first fluorinated analogue of the naturally occurring 2,4-methanoproline, 4-fluoro-2,4-methanoproline, has been synthesized in five steps from commercially available methyl 2-fluoroacrylate through a photochemical cyclization as a key step in generating a 2-azabicyclo[2.1.1]hexane skeleton.
Tkachenko
Anton N
AN
Department of Chemistry, Kyiv National Taras Shevchenko University, Vul. Volodymyrska 64, 01033 Kyiv, Ukraine.
Radchenko
Dmytro S
DS
Mykhailiuk
Pavel K
PK
Grygorenko
Oleksandr O
OO
Komarov
Igor V
IV
D053961:Azabicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011392:Proline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*
D053961:Azabicyclo Compounds; D006845:Hydrocarbons, Fluorinated; D011392:Proline