[Ru(phen)2(dppz)]2+ as an efficient optical probe for staining nuclear components.
The 'molecular light switch' complexes [Ru(bpy)(2)(dppz)](2+) (1) and [Ru(phen)(2)(dppz)](2+) (2), where bpy=2,2'-bipyridine, phen=1,10-phenanthroline and dppz=dipyrido[3,2-a:2',3'-c]phenazine, have been explored as probes for diagnosing and staining nuclear components. The phen complex acts as a better staining agent for nonviable cells than for viable cells and exhibits a staining efficiency in tail region of comet more specific and stronger than the already known dye Hoechst 33258.
Rajendiran
Venugopal
V
Centre for Bioinorganic Chemistry, School of Chemistry, Bharathidasan University, Tiruchirapalli 620 024, India.
Palaniandavar
Mallayan
M
Periasamy
Vaiyapuri Subbarayan
VS
Akbarsha
Mohammad Abdulkader
MA
D015082:2,2'-Dipyridyl / Q000737:chemistry*; D000818:Animals; D006690:Bisbenzimidazole / Q000737:chemistry; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D008214:Lymphocytes / Q000737:chemistry / Q000166:cytology; D008297:Male; D008856:Microscopy, Fluorescence; D009696:Nucleic Acids / Q000737:chemistry; D010618:Phenanthrolines / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D017975:Ruthenium Compounds / Q000737:chemistry* / Q000494:pharmacology; D013094:Spermatozoa / Q000737:chemistry / Q000166:cytology; D013997:Time Factors
D009696:Nucleic Acids; D010618:Phenanthrolines; D017975:Ruthenium Compounds; D015082:2,2'-Dipyridyl; D006690:Bisbenzimidazole; C025205:1,10-phenanthroline