title: Synergistic anti-cancer activity by the combination of TRAIL/APO-2L and celastrol.
abstract: The present study demonstrates that the combination of TRAIL/APO-2L and celastrol exerts strong synergistic antiproliferative effect against human cancer cells including ovary cancer OVCAR-8, colon cancer SW620, and lung cancer 95-D, with the combination indices below 0.8. Moreover, the in vivo antitumor efficacy of TRAIL/APO-2L was dramatically increased by celastrol. These enhanced anticancer activities were accompanied by the prompt onset of caspase-mediated apoptosis. Taken together, our data firstly demonstrate the synergistic anticancer capabilities achieved by combining TRAIL/APO-2L and celastrol, and moreover, open new opportunities to enhance the effectiveness of future treatment regimens using TRAIL/APO-2L.
authors.affiliation: Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.forename: Wan-Jing
authors.initials: WJ
authors.lastname: Ding
authors.forename: Rui
authors.initials: R
authors.lastname: Wu
authors.forename: Qin-Jie
authors.initials: QJ
authors.lastname: Weng
authors.forename: Jian-Shu
authors.initials: JS
authors.lastname: Lou
authors.forename: Rong-Jia
authors.initials: RJ
authors.lastname: Jin
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Qiao-Jun
authors.initials: QJ
authors.lastname: He
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D020169:Caspases / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004789:Enzyme Activation; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D053978:Pentacyclic Triterpenes; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000494:pharmacology; D013997:Time Factors; D014315:Triterpenes / Q000494:pharmacology; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D053978:Pentacyclic Triterpenes; D053221:TNF-Related Apoptosis-Inducing Ligand; D014315:Triterpenes; D020169:Caspases; C050414:celastrol