title: Contribution of visceral adiposity and insulin resistance to metabolic risk factors in Japanese men.
abstract: We investigated the relative impacts of visceral adiposity and insulin resistance on the metabolic risk profile in middle-aged Japanese men. A cross-sectional study was conducted in 636 nondiabetic Japanese men with a mean age of 51.6 years. Visceral adipose tissue (AT) was assessed using computed tomography, and insulin resistance was determined by the homeostasis model assessment of insulin resistance (HOMA-IR). Metabolic risk factors were diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III metabolic syndrome criteria: (1) hypertriglyceridemia, (2) low high-density lipoprotein cholesterol, (3) hypertension, (4) impaired fasting glucose, and (5) impaired glucose tolerance. Visceral AT and HOMA-IR were significantly and positively correlated with each other (r = 0.41, P < .001). Using the 75th percentile value as a cut point, those with isolated large visceral AT showed significantly greater odds ratios for each of the 5 risk factors measured except impaired fasting glucose, whereas those with isolated high HOMA-IR showed significantly greater odds ratios for each of the 5 risk factors except hypertriglyceridemia and impaired glucose tolerance, compared with the control group. The combined group (increased visceral AT and HOMA-IR) had the highest odds ratios for all studied risk factors. On logistic regression analysis using visceral AT and HOMA-IR as continuous independent variables, they were each independently associated with most of the metabolic risk factors and their clustering. In conclusion, neither visceral AT nor HOMA-IR stands out as the sole driving force of the risk profile; each makes a significant contribution to metabolic abnormalities in Japanese men.
authors.affiliation: Department of Internal Medicine, Hokuriku Central Hospital, Toyama, Japan. ririoka@goo.jp
authors.forename: Rie
authors.initials: R
authors.lastname: Oka
authors.forename: Junji
authors.initials: J
authors.lastname: Kobayashi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Inazu
authors.forename: Kunimasa
authors.initials: K
authors.lastname: Yagi
authors.forename: Susumu
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Masaru
authors.initials: M
authors.lastname: Sakurai
authors.forename: Koshi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Miura
authors.forename: Hideaki
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yamagishi
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D007564:Japan; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol