title: Selective imaging of damaged bone structure (microcracks) using a targeting supramolecular Eu(III) complex as a lanthanide luminescent contrast agent.
abstract: The synthesis and photophysical evaluation of a new supramolecular lanthanide complex is described which was developed as a luminescent contrast agent for bone structure analysis. We show that the Eu(III) emission of this complex is not pH dependent within the physiological pH range and its steady state emission is not significantly modulated by a series of group I and II as well as D-metal ions and that this agent can be successfully employed to image mechanically formed cracks (scratches) in bone samples after 4 or 24 h, using confocal laser-scanning microscopy.
authors.affiliation: School of Chemistry, Center for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland.
authors.forename: Brian
authors.initials: B
authors.lastname: McMahon
authors.forename: Peter
authors.initials: P
authors.lastname: Mauer
authors.forename: Colin P
authors.initials: CP
authors.lastname: McCoy
authors.forename: T Clive
authors.initials: TC
authors.lastname: Lee
authors.forename: Thorfinnur
authors.initials: T
authors.lastname: Gunnlaugsson
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology*; D002118:Calcium / Q000378:metabolism; D002417:Cattle; D003287:Contrast Media / Q000737:chemistry / Q000378:metabolism; D017886:Durapatite / Q000378:metabolism; D005063:Europium / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007098:Imino Acids / Q000737:chemistry; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D049408:Luminescent Agents / Q000737:chemistry / Q000378:metabolism; D018613:Microscopy, Confocal; D057054:Molecular Imaging / Q000379:methods*; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism
chemical_list: D003287:Contrast Media; D007098:Imino Acids; D028581:Lanthanoid Series Elements; D049408:Luminescent Agents; D009942:Organometallic Compounds; D005063:Europium; D017886:Durapatite; D002118:Calcium; C008109:iminodiacetic acid