title: Transformation locked in a loop.
abstract: During neoplastic transformation, cells can promote their own growth by activating proto-oncogenes. Reporting in Cell, Iliopoulos et al. (2009) now show that in certain cell types, a transient oncogenic signal is sufficient to induce neoplastic transformation and to maintain it through a positive feedback loop driven by the inflammatory cytokine interleukin-6.
authors.affiliation: Division of Gene Regulation, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
authors.forename: Jarno
authors.initials: J
authors.lastname: Drost
authors.forename: Reuven
authors.initials: R
authors.lastname: Agami
mesh_terms: D002471:Cell Transformation, Neoplastic; D025461:Feedback, Physiological; D006801:Humans; D007249:Inflammation; D015850:Interleukin-6 / Q000378:metabolism*
chemical_list: D015850:Interleukin-6