Suzuki-Miyaura coupling of aryl carbamates, carbonates, and sulfamates.
The first Suzuki-Miyaura cross-couplings of carbamates, carbonates, and sulfamates is described. The method provides a powerful means of using simple derivatives of phenol as precursors to polysubstituted aromatic compounds, as exemplified by a concise synthesis of the anti-inflammatory drug flurbiprofen.
Quasdorf
Kyle W
KW
Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
Riener
Michelle
M
Petrova
Krastina V
KV
Garg
Neil K
NK
D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry; D002254:Carbonates / Q000138:chemical synthesis* / Q000737:chemistry; D005480:Flurbiprofen / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013451:Sulfonic Acids / Q000138:chemical synthesis* / Q000737:chemistry
D002219:Carbamates; D002254:Carbonates; D013451:Sulfonic Acids; D005480:Flurbiprofen; C005741:sulfamic acid