Detection by UPLC/ESI-TOF-MS of alkaloids in three Lycopodiaceae species from French Polynesia and their anticholinesterase activity.
Three Lycopodiaceae species from French Polynesia, Lycopodium venustulum C. Gaudichaud, Lycopodiella cernua (C. Linnaeus) R. E. Pichi Sermolli and Lycopodium henryanum E. D. Brown were investigated for their alkaloidal composition by UHPLC/ESI-TOF-MS. Ten alkaloids were identified, with lycopodine and lycodoline being the main constituents in the three species. The acetylcholinesterase-inhibitory activities of the three species are probably due to the occurrence of huperzine A, huperzine B, huperzine E, huperzinine and lycopodine.
Ho
Raimana
R
Laboratoire de Pharmacognosie et Phytochimie, Section des Sciences Pharmaceutiques, Université de Genève, Université de Lausanne, CH-1211 Genève 4, Switzerland. raimana.ho@unige.ch
Marsousi
Niloufar
N
Eugster
Philippe
P
Bianchini
Jean-Pierre
JP
Raharivelomanana
Phila
P
D000470:Alkaloids / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D002853:Chromatography, Liquid / Q000379:methods*; D029542:Lycopodiaceae / Q000737:chemistry*; D015394:Molecular Structure; D018515:Plant Leaves; D011114:Polynesia; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
D000470:Alkaloids; D002800:Cholinesterase Inhibitors