title: GAB2 is not associated with late-onset Alzheimer's disease in Chinese Han.
abstract: It has recently been shown that GAB2 alleles modify the risk for late-onset Alzheimer disease (LOAD) in apolipoprotein E (ApoE)epsilon4 allele carriers in a genome-wide association study. Some studies subsequently in Caucasians population, though not all, have demonstrated that GAB2 polymorphisms might be associated with LOAD susceptibility. The aim of this study is to evaluate the reported polymorphisms (rs2373115 and rs1385600) and GAB2 haplotypes (rs2373115-rs1385600) for an interaction with the ApoEepsilon4 allele in a cohort of Chinese LOAD. We conducted a case-control study in 292 LOAD and 227 non-demented controls from the Chinese Han population. Our study does not find any association between the two tested SNPs and GAB2 haplotypes and LOAD or any synergetic interaction between the SNPs and ApoE either. However, since the sample size required to show this point is large, our finding needs to be confirmed by a large independent sample of Chinese population.
authors.affiliation: Department of Gerontology, Guangzhou Psychiatric Hospital, Affiliated Hospital of Guangzhou Medical College, 510370, Guangzhou, China. linkangguang@163.com
authors.forename: Kangguang
authors.initials: K
authors.lastname: Lin
authors.forename: Muni
authors.initials: M
authors.lastname: Tang
authors.forename: Haiying
authors.initials: H
authors.lastname: Han
authors.forename: Yangbo
authors.initials: Y
authors.lastname: Guo
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Lin
authors.forename: Cui
authors.initials: C
authors.lastname: Ma
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D015331:Cohort Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D053327:Apolipoprotein E4; C490895:GAB2 protein, human