Transformation locked in a loop.
During neoplastic transformation, cells can promote their own growth by activating proto-oncogenes. Reporting in Cell, Iliopoulos et al. (2009) now show that in certain cell types, a transient oncogenic signal is sufficient to induce neoplastic transformation and to maintain it through a positive feedback loop driven by the inflammatory cytokine interleukin-6.
Drost
Jarno
J
Division of Gene Regulation, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Agami
Reuven
R
D002471:Cell Transformation, Neoplastic; D025461:Feedback, Physiological; D006801:Humans; D007249:Inflammation; D015850:Interleukin-6 / Q000378:metabolism*
D015850:Interleukin-6