Hedgehog signalling: Kif7 is not that fishy after all.
Recent reports examining the mammalian kinesin relative Kif7 highlight the conserved role for microtubule motor proteins in Drosophila and vertebrate Hedgehog signalling. Mammalian Kif7 action centres at the primary cilium, an organelle absent from Drosophila. These studies raise interesting questions about the coupling of microtubule trafficking to the Hedgehog pathway.
Ingham
Philip W
PW
Institute of Molecular and Cellular Biology, 61, Biopolis Drive, Proteos, Singapore. pingham@imcb.a-star.edu.sg
McMahon
Andrew P
AP
D000818:Animals; D019521:Body Patterning; D004330:Drosophila / Q000378:metabolism; D029721:Drosophila Proteins / Q000502:physiology; D053823:Hedgehog Proteins / Q000378:metabolism*; D016547:Kinesins / Q000502:physiology*; D051379:Mice; D015398:Signal Transduction
D029721:Drosophila Proteins; D053823:Hedgehog Proteins; C107452:cos protein, Drosophila; C543639:Kif7 protein, mouse; D016547:Kinesins