title: Bio-transformation of artemisinin using soil microbe: Direct C-acetoxylation of artemisinin at C-9 by Penicillium simplissimum.
abstract: Potent antimalarial compound artemisinin, 1 was bio-transformed to C-9 acetoxy artemisinin, 2 using soil microbe Penicillium simplissimum along with C-9 hydroxy derivative 3. The products were characterized using high field NMR and MS-MS data. The absolute stereochemistry of the newly generated chiral centers has been ascertained by COSY and 1D NOESY experiments. This is the first Letter of direct C-acetoxylation of artemisinin using microbial strains.
authors.affiliation: Natural Products Chemistry Division, North-East Institute of Science & Technology (CSIR), Jorhat 785 006, Assam, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Goswami
authors.forename: Partha P
authors.initials: PP
authors.lastname: Saikia
authors.forename: Nabin C
authors.initials: NC
authors.lastname: Barua
authors.forename: Manobjyoti
authors.initials: M
authors.lastname: Bordoloi
authors.forename: Archana
authors.initials: A
authors.lastname: Yadav
authors.forename: Tarun C
authors.initials: TC
authors.lastname: Bora
authors.forename: Binod K
authors.initials: BK
authors.lastname: Gogoi
authors.forename: Ajit Kumar
authors.initials: AK
authors.lastname: Saxena
authors.forename: Nithasa
authors.initials: N
authors.lastname: Suri
authors.forename: Madhunika
authors.initials: M
authors.lastname: Sharma
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D037621:Artemisinins / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D001711:Biotransformation; D002460:Cell Line; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010407:Penicillium / Q000378:metabolism*; D012988:Soil Microbiology; D012989:Soil Pollutants / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D012989:Soil Pollutants; C031327:artemisinin