Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation.
The aim of this work was to determine the effect of chronic treatment with 5 mg/kg of tianeptine in male adult Wistar rats separated from the mother as neonates and submitted to variable chronic stress, plasma catecholamines, and anxiety. The plus maze test was performed in order to calculate the anxiety index and catecholamine levels were determined by high-pressure liquid chromatography. Both stress and maternal separation elevated catecholamine levels without affecting anxiety. In the maternally separated stress group, tianeptine decreased epinephrine. Anxiety was reduced in the maternally separated unstressed tianeptine group. Also, all groups showed a tendency to lower anxiety index.
Trujillo
Verónica
V
Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, Argentina.
Masseroni
María Lujan
ML
Levin
Gloria
G
Suárez
Marta Magdalena
MM
D000305:Adrenal Cortex Hormones / Q000097:blood; D000313:Adrenal Medulla / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D001007:Anxiety / Q000097:blood* / Q000188:drug therapy* / Q000523:psychology; D001010:Anxiety, Separation / Q000097:blood* / Q000150:complications* / Q000523:psychology; D001522:Behavior, Animal / Q000502:physiology; D002395:Catecholamines / Q000097:blood*; D002908:Chronic Disease; D005260:Female; D008297:Male; D008426:Maternal Deprivation; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000097:blood* / Q000150:complications* / Q000523:psychology; D013841:Thiazepines / Q000627:therapeutic use*
D000305:Adrenal Cortex Hormones; D000929:Antidepressive Agents, Tricyclic; D002395:Catecholamines; D013841:Thiazepines; C050504:tianeptine