Terbinafine-induced acute generalized exanthematous pustulosis (AGEP) responsive to high dose intravenous corticosteroid.
Acute generalized exanthematous pustulosis (AGEP) is a febrile pustular drug eruption. Terbinafine, an allylamine fungicidial agent, is the most common anti-mycotic associated with AGEP. Here, we report a case of terbinafine-induced AGEP that was recalcitrant to oral corticosteroid but responsive to high-dose intravenous corticosteroid.
Ibrahimi
Omar A
OA
Harvard Medical School, Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Gunawardane
Nilanthi
N
Sepehr
Alireza
A
Reynolds
Rachel V
RV
D056150:Acute Generalized Exanthematous Pustulosis / Q000139:chemically induced* / Q000188:drug therapy; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000009:adverse effects*; D002990:Clobetasol / Q000008:administration & dosage / Q000627:therapeutic use; D004155:Diphenhydramine / Q000008:administration & dosage / Q000627:therapeutic use; D005221:Fatigue / Q000209:etiology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009281:Naphthalenes / Q000009:adverse effects*; D014009:Onychomycosis / Q000188:drug therapy; D010146:Pain / Q000209:etiology; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D000077291:Terbinafine
D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D009281:Naphthalenes; D004155:Diphenhydramine; D002990:Clobetasol; D000077291:Terbinafine; D011241:Prednisone; D008775:Methylprednisolone