title: Photochemical stereospecific hydrogenation of a Ru complex with an NAD(+)/NADH-type ligand.
abstract: A polypyridylruthenium complex with an NAD(+)/NADH model ligand, [Ru(bpy)(2)(pbn)](2+) [bpy = 2,2'-bipyridine; pbn = 2-(2-pyridyl)benzo[b]-1,5-naphthyridine] in a D(2)O/CH(3)CN/triethylamine solution, undergoes stereospecific hydrogenation to give Delta-(S)- and Lambda-(R)-[Ru(bpy)(2)(pbnDD)](2+) [pbnDD = 5,10-dideutero-2-(2-pyridyl)benzo[b]-1,5-naphthyridine] upon visible-light irradiation. This result clearly indicates the pathway via the pi-stacked dimer of the deuterated one-electron-reduced species. The reduction of [Ru(bpy)(2)(pbn)](2+) with Na(2)S(2)O(4) in D(2)O did not afford any stereospecific products. Furthermore, the more sterically crowded Ru complex, [Ru(dmb)(2)(pbn)](2+) (dmb = 6,6'-dimethyl-2,2'-bipyridine), did not produce the corresponding pbnDD species upon irradiation.
authors.affiliation: Institute for Molecular Science (IMS), 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukushima
authors.forename: Etsuko
authors.initials: E
authors.lastname: Fujita
authors.forename: James T
authors.initials: JT
authors.lastname: Muckerman
authors.forename: Dmitry E
authors.initials: DE
authors.lastname: Polyansky
authors.forename: Tohru
authors.initials: T
authors.lastname: Wada
authors.forename: Koji
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D018360:Crystallography, X-Ray; D006863:Hydrogen-Ion Concentration; D006865:Hydrogenation; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009243:NAD / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010777:Photochemistry; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D008024:Ligands; D009942:Organometallic Compounds; D009243:NAD; D012428:Ruthenium