title: Clinical value of computed tomography perfusion source images in acute stroke.
abstract: Computed tomography perfusion (CTP) map can sensitively and accurately distinguish between infarct core and ischemic penumbra. However, CTP mapping software might not generate a perfusion map because of head movement; thus, analysing CTP source images (CTP-SI) is necessary in this situation to provide information for stroke diagnosis and therapy. In our work, 'one-stop shop' computed tomography (CT) examination including non-contrast-enhanced CT (NCCT), CTP, CT angiography (CTA) were performed in 24 patients with symptoms of acute stroke less than 9 hours. We divided patients into two groups (with and without delayed perfusion on CTP-SI), and compared the Alberta Stroke Program Early CT Score (ASPECTS) on CTP-SI and CTA-SI with follow-up imaging. Using follow-up imaging ASPECTS as the final infarct size, our results suggests that the ASPECTS of both CTP-SI and CTA-SI effectively predict final infarct core in the group without delayed perfusion, whereas CTP-SI has a potential advantage over CTA-SI in being able to predict final infarct core in the group with delayed perfusion. In conclusion, CTP-SI provides useful complementary information when CTP map software could not generate perfusion maps.
authors.affiliation: Department of Neuroradiology, Beijing Neurosurgical Institute, Affiliated Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Xiao-Chun
authors.initials: XC
authors.lastname: Wang
authors.forename: Pei-Yi
authors.initials: PY
authors.lastname: Gao
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.lastname: Guan-ruiLiu
authors.forename: Jing
authors.initials: J
authors.lastname: Xue
authors.forename: Bin-Bin
authors.initials: BB
authors.lastname: Sui
authors.forename: Chun-Juan
authors.initials: CJ
authors.lastname: Wang
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D003287:Contrast Media; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D020244:Infarction, Middle Cerebral Artery / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D010477:Perfusion / Q000379:methods*; D012720:Severity of Illness Index; D020521:Stroke / Q000000981:diagnostic imaging*; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media