Molarless condition suppresses proliferation but not differentiation rates into neurons in the rat dentate gyrus.
The dentate gyrus (DG) of the hippocampal complex is one of the few areas of the rodent brain where neurogenesis continues throughout adulthood. We investigated the effects of the molarless condition on cell proliferation, rate of differentiation into neurons in the subgranular zone of the DG, and plasma corticosterone levels. The molarless condition decreased cell proliferation in the DG and increased plasma corticosterone levels. Approximately 80% of newly generated cells differentiated into neurons and the remaining 20% of the cells differentiated into astrocytes. These ratios were not significantly different between control and molarless rats. In conclusion, the rates of neurogenesis and gliogenesis in the DG are suppressed by the molarless condition, and this suppression might be associated with the increased corticosteroid levels in molarless subjects.
Aoki
Hiromichi
H
Division of Fixed Prosthodontics, Department of Oral & Maxillofacial Rehabilitation, Kanagawa Dental College, Yokosuka 238-8580, Japan.
Kimoto
Katsuhiko
K
Hori
Norio
N
Hoshi
Noriyuki
N
Yamamoto
Toshiharu
T
Onozuka
Minoru
M
D000818:Animals; D001253:Astrocytes / Q000166:cytology; D002454:Cell Differentiation; D049109:Cell Proliferation; D003345:Corticosterone / Q000097:blood; D018891:Dentate Gyrus / Q000166:cytology*; D008297:Male; D008963:Molar / Q000502:physiology*; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar; D013234:Stem Cells / Q000166:cytology*
D003345:Corticosterone