Overview of known non-human primate pathogens with potential to affect colonies used for toxicity testing.
The increased demand for non-human primates (NHPs) in biomedical research has resulted in alternative sources of animals being used, which has allowed for importation of animals with varying background incidences of bacterial, viral, parasitic, and fungal pathogens. This can be of minimal consequence when animals from different sources are kept isolated. However, when NHPs from different sources with varying incidences of primary and opportunistic pathogens are mixed, there can be a rapid spread of these pathogens and an increase in the seroconversion of susceptible animals. If this process occurs during the conduct of a study, interpretation of that study can be confounded. Furthermore, NHPs imported from areas enzootic for pathogens such as Plasmodium or with high incidences of human diseases such as measles and tuberculosis can introduce diseases that can be a threat to colony health, have zoonotic risk, and can severely impact study outcome. Thus, knowledge of the common primary and opportunistic NHP infections, as well as reemerging pathogens, enables the toxicologist to use information on disease status for pre-study animal selection and intelligent study design. This is particularly important when immunomodulatory compounds are being investigated. Moreover, the toxicologic pathologist well versed in the common spontaneous infections, opportunistic pathogens, and background lesions in NHPs is able to assess possible drug-related effects in drug safety studies. This review identifies the common primary and opportunistic pathogens, as well as newly emerging infections of NHPs, that can directly or indirectly affect colony health and the interpretation of drug safety studies.
Sasseville
Vito G
VG
Bristol-Myers Squibb Research and Development, Discovery Toxicology, Princeton, NJ 08543, USA. vito.sasseville@bms.com
Mansfield
Keith G
KG
D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology / Q000662:veterinary; D017848:Blood-Borne Pathogens; D003141:Communicable Diseases / Q000382:microbiology / Q000662:veterinary*; D008252:Macaca fascicularis / Q000382:microbiology*; D008992:Monkey Diseases / Q000382:microbiology*; D009181:Mycoses / Q000382:microbiology / Q000662:veterinary; D009894:Opportunistic Infections / Q000382:microbiology / Q000662:veterinary*; D010273:Parasitic Diseases, Animal / Q000382:microbiology; D018675:Toxicity Tests; D014777:Virus Diseases / Q000662:veterinary; D015047:Zoonoses / Q000382:microbiology*