title: Efficacy of a combination product containing pyrantel, febantel and praziquantel (Drontal Plus Flavour, Bayer Animal Health) against experimental infection with the hookworm Ancylostoma ceylanicum in dogs.
abstract: Ancylostoma ceylanicum is a common hookworm of dogs, cats and humans in Asia. More recently, this hookworm was found to infect dogs in Australia. The objective of this study was to determine the efficacy of a combination product containing pyrantel, febantel and praziquantel (Drontal) Plus Flavour, Bayer) against A. ceylanicum in experimentally infected dogs. Twelve dogs were each subcutaneously injected with 300 infective third-stage larvae of A. ceylanicum. Pups were stratified by egg count and randomly allocated equally into control and treatment groups. The pups in the treatment group were treated orally at 20 days post-infection with a tablet containing pyrantel, febantel and praziquantel (Drontal Plus Flavour, Bayer) with the recommended dose of one tablet per 10 kg bodyweight. The dogs in the control group were not treated. Egg counts were performed daily until the end of the study period and compared for the treated and control groups. No eggs were detected in the treated group of pups within 3 days of treatment, and faecal samples from this group remained negative throughout the rest of the study resulting in a treatment efficacy (egg reduction) of 100% (p = 0.0011). The egg counts for the untreated group remained high for the rest of the study period. This trial demonstrated that a combination tablet containing pyrantel, febantel and praziquantel (Drontal Plus Flavour, Bayer) given at the manufacturer's recommended dose is effective against infection with A. ceylanicum in dogs.
authors.affiliation: Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand. Piyanan.T@chula.ac.th
authors.forename: Piyanan
authors.initials: P
authors.lastname: Taweethavonsawat
authors.forename: Sudchit
authors.initials: S
authors.lastname: Chungpivat
authors.forename: Pakkawan
authors.initials: P
authors.lastname: Satranarakun
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Traub
authors.forename: Roland
authors.initials: R
authors.lastname: Schaper
mesh_terms: D000722:Ancylostoma / Q000302:isolation & purification*; D000724:Ancylostomiasis / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D004338:Drug Combinations; D005243:Feces / Q000469:parasitology; D006146:Guanidines / Q000627:therapeutic use*; D010270:Parasite Egg Count; D011223:Praziquantel / Q000627:therapeutic use*; D011715:Pyrantel / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000871:Anthelmintics; D004338:Drug Combinations; D006146:Guanidines; D011715:Pyrantel; D011223:Praziquantel; C017309:febantel