title: Nanocrystalline zirconia: a novel sorbent for the preparation of (188)W/(188)Re generator.
abstract: Nanocrystalline zirconia, a novel high capacity sorbent material was synthesized and tested for its utility in the preparation of (188)W/(188)Re generators. The structural investigation of the material was carried out using X-ray diffraction, surface area determination, FTIR and TEM micrograph analysis. Various experimental parameters were optimized to separate (188)Re from (188)W. The capacity of the material was found to be approximately 325mgW/g at the optimum pH. A chromatographic (188)W/(188)Re generator was developed using this material from which >80% of (188)Re generated could be eluted with 0.9% saline solution, with high radionuclidic, radiochemical and chemical purity and appreciably high radioactive concentration suitable for radiopharmaceutical applications.
authors.affiliation: Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai-400085, India.
authors.forename: Rubel
authors.initials: R
authors.lastname: Chakravarty
authors.forename: Rakesh
authors.initials: R
authors.lastname: Shukla
authors.forename: A K
authors.initials: AK
authors.lastname: Tyagi
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Dash
authors.forename: Meera
authors.initials: M
authors.lastname: Venkatesh
mesh_terms: D000042:Absorption; D003460:Crystallization / Q000379:methods; D007553:Isotope Labeling / Q000379:methods; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D011868:Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification; D012211:Rhenium / Q000737:chemistry* / Q000302:isolation & purification; D014414:Tungsten / Q000737:chemistry* / Q000302:isolation & purification; D014462:Ultrafiltration / Q000379:methods*; D015040:Zirconium / Q000737:chemistry*
chemical_list: D011868:Radioisotopes; D012211:Rhenium; D015040:Zirconium; C028541:zirconium oxide; D014414:Tungsten