title: Neural correlates (ERP/fMRI) of voluntary selection in adult ADHD patients.
abstract: Deficits in executive functions, e.g. voluntary selection, are considered central to the attention-deficit/hyperactivity disorder (ADHD). The aim of this simultaneous EEG/fMRI study was to examine associated neural correlates in ADHD patients. Patients with ADHD and healthy subjects performed an adapted go/nogo task including a voluntary selection condition allowing participants to freely decide, whether to press the response button. Electrophysiologically, response inhibition and voluntary selection led to fronto-central responses. The fMRI data revealed increased medial/lateral frontal and parietal activity during the voluntary selection task. Frontal brain responses were reduced in ADHD patients compared to controls during free responses, whereas parietal brain functions seemed to be unaffected. These results may indicate that selection processes are related to dysfunctions, predominantly in frontal brain regions in ADHD patients.
authors.affiliation: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336, Munich, Germany. Susanne.Karch@med.uni-muenchen.de
authors.forename: Susanne
authors.initials: S
authors.lastname: Karch
authors.forename: Tobias
authors.initials: T
authors.lastname: Thalmeier
authors.forename: Jürgen
authors.initials: J
authors.lastname: Lutz
authors.forename: Anja
authors.initials: A
authors.lastname: Cerovecki
authors.forename: Markus
authors.initials: M
authors.lastname: Opgen-Rhein
authors.forename: Bettina
authors.initials: B
authors.lastname: Hock
authors.forename: Gregor
authors.initials: G
authors.lastname: Leicht
authors.forename: Kristina
authors.initials: K
authors.lastname: Hennig-Fast
authors.forename: Thomas
authors.initials: T
authors.lastname: Meindl
authors.forename: Michael
authors.initials: M
authors.lastname: Riedel
authors.forename: Christoph
authors.initials: C
authors.lastname: Mulert
authors.forename: Oliver
authors.initials: O
authors.lastname: Pogarell
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000473:pathology* / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology*; D001931:Brain Mapping; D003657:Decision Making / Q000502:physiology; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology*; D056344:Executive Function; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D013223:Statistics as Topic
chemical_list: D010100:Oxygen