title: A facile and practical synthesis of N-acetyl enamides.
abstract: A facile and practical method for the synthesis of N-acetyl alpha-arylenamides has been developed from corresponding ketoximes as the starting materials with ferrous acetate as the reducing reagent. This methodology offers mild reaction conditions, simple purification procedures, and high yields for a variety of N-acetyl enamides.
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut 06877, USA. wenjun.tang@boehringer-ingelheim.com
authors.forename: Wenjun
authors.initials: W
authors.lastname: Tang
authors.forename: Andrew
authors.initials: A
authors.lastname: Capacci
authors.forename: Max
authors.initials: M
authors.lastname: Sarvestani
authors.forename: Xudong
authors.initials: X
authors.lastname: Wei
authors.forename: Nathan K
authors.initials: NK
authors.lastname: Yee
authors.forename: Chris H
authors.initials: CH
authors.lastname: Senanayake
mesh_terms: D000085:Acetates / Q000737:chemistry; D000107:Acetylation; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry*; D005296:Ferrous Compounds / Q000737:chemistry; D006844:Hydrocarbons, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D006865:Hydrogenation; D009682:Magnetic Resonance Spectroscopy; D010091:Oximes / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D000085:Acetates; D000577:Amides; D005296:Ferrous Compounds; D006844:Hydrocarbons, Cyclic; D010091:Oximes; D012997:Solvents