title: The spectrum of abnormal neurologic outcomes subsequent to term intrapartum asphyxia.
abstract: The purpose of this study was to describe the spectrum of possible abnormal neurologic outcomes in term infants with intrapartum asphyxia and to identify those clinical factors associated with the later occurrence of cerebral palsy. All children with term intrapartum asphyxia encountered in a single pediatric neurologic practice with at least 2 years of follow-up and an abnormal neurologic outcome were identified. Abnormal outcomes were grouped into those with or without cerebral palsy. A total of 40 children (28 male, 12 female) met study criteria. Of these, 23 developed cerebral palsy; the remaining 17 children developed an abnormal neurologic outcome that did not include cerebral palsy. A more severe grade of neonatal encephalopathy, a higher number of neonatal seizures, the neonatal use of phenytoin, diffuse abnormalities on imaging, and abnormal findings on neurologic examination at neonatal discharge were all significantly (P<0.05) associated with an abnormal outcome that included cerebral palsy. Abnormal neurologic outcomes other than cerebral palsy subsequent to term intrapartum asphyxia may occur. It appears that a more severe grade of apparent initial clinical injury is more likely to result in an outcome featuring cerebral palsy.
authors.affiliation: Department of Neurology and Neurosurgery, Montreal Children's Hospital-McGill University Health Center, Montreal, Quebec H3H 1P3, Canada.
authors.forename: Nabil
authors.initials: N
authors.lastname: Al-Macki
authors.forename: Steven P
authors.initials: SP
authors.lastname: Miller
authors.forename: Nicholas
authors.initials: N
authors.lastname: Hall
authors.forename: Michael
authors.initials: M
authors.lastname: Shevell
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D001238:Asphyxia Neonatorum / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D002547:Cerebral Palsy / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology*; D009460:Neurologic Examination; D010672:Phenytoin / Q000627:therapeutic use; D011379:Prognosis; D012640:Seizures / Q000188:drug therapy / Q000209:etiology; D012720:Severity of Illness Index
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin