Fine mapping quantitative trait loci affecting milk production traits on bovine chromosome 6 in a Chinese Holstein population.
To fine map the previously detected quantitative trait loci (QTLs) affecting milk production traits on bovine chromosome 6 (BTA6), 15 microsatellite markers situated within an interval of 14.3 cM spanning from BMS690 to BM4528 were selected and 918 daughters of 8 sires were genotyped. Two mapping approaches, haplotype sharing based LD mapping and single marker regression mapping, were used to analyze the data. Both approaches revealed a quantitative trait locus (QTL) with significant effects on milk yield, fat yield and protein yield located in the segment flanked by markers BMS483 and MNB209, which spans a genetic distance of 0.6 cM and a physical distance of 1.5 Mb. In addition, the single marker regression mapping also revealed a QTL affecting fat percentage and protein percentage at marker DIK2291. Our fine mapping work will facilitate the cloning of candidate genes underlying the QTLs for milk production traits.
Mei
Gui
G
State Key Laboratory for Agrobiotechnology, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Yin
Cengceng
C
Ding
Xiangdong
X
Zhang
Qin
Q
D000818:Animals; D002417:Cattle / Q000235:genetics* / Q000502:physiology; D002681:China; D033481:Chromosomes, Mammalian / Q000235:genetics*; D005260:Female; D007774:Lactation / Q000235:genetics*; D008297:Male; D008892:Milk / Q000737:chemistry; D020161:Physical Chromosome Mapping / Q000662:veterinary; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable