title: Amino acid based enantiomerically pure 3-substituted benzofused heterocycles: A new class of antithrombotic agents.
abstract: A diverse group of novel medium ring heterocycles derived from naturally abundant proteinogenic amino acids were evaluated for their potency towards antithrombotic activity. The more potent benzofused oxazepine and oxazocine scaffolds were diversified by incorporating different amino acids at the position number 3. Further the effect of ring size has also been taken into account and it was observed that the eight-membered oxazocines ane more potent compared to the corresponding oxazepines.
authors.affiliation: Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, UP, India.
authors.forename: Jitendra Kumar
authors.initials: JK
authors.lastname: Mishra
authors.forename: Krishnananda
authors.initials: K
authors.lastname: Samanta
authors.forename: Manish
authors.initials: M
authors.lastname: Jain
authors.forename: Madhu
authors.initials: M
authors.lastname: Dikshit
authors.forename: Gautam
authors.initials: G
authors.lastname: Panda
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D001569:Benzodiazepines / Q000737:chemistry; D005343:Fibrinolytic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010077:Oxazepines / Q000737:chemistry; D010079:Oxazocines / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D005343:Fibrinolytic Agents; D006574:Heterocyclic Compounds, 2-Ring; D010077:Oxazepines; D010079:Oxazocines; D001569:Benzodiazepines