title: In situ hypothermic liver preservation during radical liver resection with major vascular reconstruction.
abstract: BACKGROUND
  The in situ hypothermic liver preservation technique may allow a more aggressive approach to tumours of the caval confluence and/or all three hepatic veins, which would otherwise be deemed irresectable.
  
  
  METHODS
  All descriptive data regarding patient demographics, operative characteristics, perioperative complications and outcomes of nine patients in whom this technique was used were collected prospectively.
  
  
  RESULTS
  Seven patients underwent liver trisegmentectomy and two had primary retrohepatic venal caval resection. Total hepatic vascular occlusion with in situ hypothermic liver preservation was used for venous reconstruction in all patients. The vena cava was reconstructed with prosthetic graft in seven patients. All main hepatic veins were reconstructed in the seven liver resections. In situ hypothermic liver preservation was well tolerated as evidenced by preserved hepatic synthetic function early after operation. One patient died 66 days after surgery. There were two recurrences after a median follow-up of 14 (range 2-33) months; local recurrence was identified in one patient after 4 months and distant metastasis in another after 8 months.
  
  
  CONCLUSIONS
  The in situ hypothermic liver preservation technique appears to be a useful adjunct to radical hepatobiliary tumour excision procedures that require total hepatic vascular exclusion and major vascular reconstruction.
authors.affiliation: Liver Transplant Unit, Multiorgan Transplant Program, University of Toronto and Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Dubay
authors.forename: S
authors.initials: S
authors.lastname: Gallinger
authors.forename: L
authors.initials: L
authors.lastname: Hawryluck
authors.forename: C
authors.initials: C
authors.lastname: Swallow
authors.forename: S
authors.initials: S
authors.lastname: McCluskey
authors.forename: I
authors.initials: I
authors.lastname: McGilvray
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D018281:Cholangiocarcinoma / Q000601:surgery; D006498:Hepatectomy / Q000379:methods*; D006503:Hepatic Veins / Q000601:surgery; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D007430:Intraoperative Care; D007890:Leiomyosarcoma / Q000601:surgery; D008113:Liver Neoplasms / Q000098:blood supply / Q000601:surgery*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D009442:Neurilemmoma / Q000601:surgery; D012086:Reoperation; D015424:Reperfusion / Q000379:methods; D014021:Tissue Preservation; D014057:Tomography, X-Ray Computed; D019043:Vascular Neoplasms / Q000601:surgery*; D014656:Vascular Surgical Procedures / Q000379:methods*; D014684:Venae Cavae / Q000601:surgery
chemical_list: D000925:Anticoagulants