Unique structure and property of cyclodextrins and their application in transdermal drug delivery.
Owing to their bioadaptability and multifunctional characteristics, cyclodextrins have been shown to be useful in drug delivery systems. This article presents the unique structure and properties and the current application of natural and chemically modified cyclodextrins in transdermal drug delivery systems, focusing on their ability to enhance the solubility and stability of drug molecules and to improve drug absorption across biological barriers.
Hu
J
J
School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013, China. hujiechem@hotmail.com
Tao
Z
Z
Cao
S
S
D000279:Administration, Cutaneous; D000818:Animals; D002626:Chemistry, Pharmaceutical; D003505:Cyclodextrins / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D016503:Drug Delivery Systems; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D012869:Skin Absorption; D012995:Solubility
D003505:Cyclodextrins; D005079:Excipients