title: Increased carotid intima-media thickness as a predictor of the presence and extent of abnormal myocardial perfusion in type 2 diabetes.
abstract: OBJECTIVE
  Identification of asymptomatic patients with type 2 diabetes at increased risk for coronary artery disease (CAD) remains a challenge. We evaluated the potential of carotid intima-media thickness (CIMT) for prediction of abnormal myocardial perfusion in this population.
  
  
  METHODS
  CIMT and SPECT myocardial perfusion imaging were assessed in 98 asymptomatic patients with type 2 diabetes. An increased CIMT was defined as > or =75th percentile of reference values. RESULTS Increased CIMT was an independent predictor of the extent of abnormal perfusion (P < 0.001). In patients with increased CIMT as compared with patients with normal CIMT, abnormal perfusion (75 vs. 9%) and severely abnormal perfusion (28 vs. 3%) were observed more frequently.
  
  
  CONCLUSIONS
  Increased CIMT was significantly related to the presence and extent of abnormal myocardial perfusion. Assessment of CIMT may be useful to identify asymptomatic patients with type 2 diabetes at higher risk for CAD.
authors.affiliation: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Roxana
authors.initials: R
authors.lastname: Djaberi
authors.forename: Joanne D
authors.initials: JD
authors.lastname: Schuijf
authors.forename: J Wouter
authors.initials: JW
authors.lastname: Jukema
authors.forename: Ton J
authors.initials: TJ
authors.lastname: Rabelink
authors.forename: Marcel P
authors.initials: MP
authors.lastname: Stokkel
authors.forename: Jan W
authors.initials: JW
authors.lastname: Smit
authors.forename: Eelco J
authors.initials: EJ
authors.lastname: de Koning
authors.forename: Jeroen J
authors.initials: JJ
authors.lastname: Bax
mesh_terms: D002339:Carotid Arteries / Q000000981:diagnostic imaging* / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D055414:Myocardial Perfusion Imaging; D012307:Risk Factors; D017539:Tunica Intima / Q000000981:diagnostic imaging* / Q000473:pathology*; D017540:Tunica Media / Q000000981:diagnostic imaging* / Q000473:pathology*; D014463:Ultrasonography