Magnetic brain stimulation upregulates adhesion and prevents Eae: MMP-2, ICAM-1, and VCAM-1 in the choroid plexus as a target.
Clinical signs appearance and significant increases of ICAM-1 and MMP-2 expressions with the clusters of VCAM-1(+) immunoreactivity in the choroids plexus epithelium to transferred anti-myelin oligodendroglial antibodies into the third brain ventricle, indicate important role of choroids plexus in the induction of acute experimental autoimmune encephalomyelitis (EAE). Magnetic brain stimulation with AKMA micro-magnet flux density of 60 miliTesla, 5 mm in diameter, implanted upon the pineal gland (PG), immediately after antibody injection, significantly decreases the expression of MMP-2 and ICAM-1 in the choroids plexus of the rat brain and abruptly suppresses the induction of acute EAE.
Jovanova-Nesic
K
K
Immunology Research Center Branislav Jankovic, 45811152 Belgrade, Serbia. nesic@torlakinstitut.com
Jovicic
S
S
Sovilj
M
M
Spector
N Herbert
NH
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D002452:Cell Count; D002831:Choroid Plexus / Q000187:drug effects / Q000378:metabolism*; D046690:Deep Brain Stimulation; D004567:Electrodes, Implanted; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis*; D009186:Myelin Sheath / Q000378:metabolism; D009836:Oligodendroglia / Q000473:pathology; D051381:Rats; D020542:Third Ventricle / Q000378:metabolism; D015854:Up-Regulation; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis*
D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D020778:Matrix Metalloproteinase 2