title: Pure drug and polymer based nanotechnologies for the improved solubility, stability, bioavailability and targeting of anti-HIV drugs.
abstract: The impact of human immunodeficiency virus (HIV) infection has been devastating with nearly 7400 new infections every day. Although, the advent of highly active antiretroviral therapy (HAART) has made a tremendous contribution in reducing the morbidity and mortality in developed countries, the situation in developing countries is still grim with millions of people being infected by this disease. The new advancements in the field of nanotechnology based drug delivery systems hold promise to improve the situation. These nanoscale systems have been successfully employed in other diseases such as cancer, and therefore, we now have a better understanding of the practicalities and technicalities associated with their clinical development. Nanotechnology based approaches offer some unique opportunities specifically for the improvement of water solubility, stability, bioavailability and targeting of antiretroviral drugs. This review presents discussion on the contribution of pure drug and polymer based nanotechnologies for the delivery anti-HIV drugs.
authors.affiliation: School of Pharmacy, The University of Auckland, Auckland, New Zealand.
authors.forename: Puneet
authors.initials: P
authors.lastname: Sharma
authors.forename: Sanjay
authors.initials: S
authors.lastname: Garg
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001682:Biological Availability; D050091:Dendrimers; D003906:Developing Countries; D004355:Drug Stability; D006801:Humans; D008823:Micelles; D036103:Nanotechnology / Q000639:trends*; D011108:Polymers; D012995:Solubility
chemical_list: D019380:Anti-HIV Agents; D050091:Dendrimers; D008823:Micelles; D011108:Polymers