title: Hedgehog signalling: Kif7 is not that fishy after all.
abstract: Recent reports examining the mammalian kinesin relative Kif7 highlight the conserved role for microtubule motor proteins in Drosophila and vertebrate Hedgehog signalling. Mammalian Kif7 action centres at the primary cilium, an organelle absent from Drosophila. These studies raise interesting questions about the coupling of microtubule trafficking to the Hedgehog pathway.
authors.affiliation: Institute of Molecular and Cellular Biology, 61, Biopolis Drive, Proteos, Singapore. pingham@imcb.a-star.edu.sg
authors.forename: Philip W
authors.initials: PW
authors.lastname: Ingham
authors.forename: Andrew P
authors.initials: AP
authors.lastname: McMahon
mesh_terms: D000818:Animals; D019521:Body Patterning; D004330:Drosophila / Q000378:metabolism; D029721:Drosophila Proteins / Q000502:physiology; D053823:Hedgehog Proteins / Q000378:metabolism*; D016547:Kinesins / Q000502:physiology*; D051379:Mice; D015398:Signal Transduction
chemical_list: D029721:Drosophila Proteins; D053823:Hedgehog Proteins; C107452:cos protein, Drosophila; C543639:Kif7 protein, mouse; D016547:Kinesins