title: Coronary abnormalities in hyper-IgE recurrent infection syndrome: depiction at coronary MDCT angiography.
abstract: OBJECTIVE
  Hyper-IgE recurrent infection syndrome (HIES or Job's syndrome) is a rare disorder affecting the immune system and connective tissues. The purpose of this study is to describe the coronary abnormalities in genetically confirmed HIES patients as depicted by coronary MDCT angiography (MDCTA).
  
  
  CONCLUSIONS
  Coronary MDCTA has provided an opportunity for noninvasive evaluation of the coronary arteries in patients with HIES. These coronary abnormalities vary from tortuosity to ectatic dilation and focal aneurysms of the coronary arteries. Such an evaluation has potential value in identifying new aspects of this disease and thereby providing better understanding of the pathophysiology of the disorder.
authors.affiliation: Department of Radiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Clinical Research Center, Bethesda, MD 20892, USA. agharib@mail.nih.gov
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Gharib
authors.forename: Roderic I
authors.initials: RI
authors.lastname: Pettigrew
authors.forename: Abdalla
authors.initials: A
authors.lastname: Elagha
authors.forename: Amy
authors.initials: A
authors.lastname: Hsu
authors.forename: Pam
authors.initials: P
authors.lastname: Welch
authors.forename: Steven M
authors.initials: SM
authors.lastname: Holland
authors.forename: Alexandra F
authors.initials: AF
authors.lastname: Freeman
mesh_terms: D000328:Adult; D003287:Contrast Media; D017023:Coronary Angiography / Q000379:methods*; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D007073:Immunoglobulin E / Q000097:blood; D007479:Iopamidol; D007589:Job Syndrome / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011857:Radiographic Image Interpretation, Computer-Assisted; D012008:Recurrence; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D007073:Immunoglobulin E; D007479:Iopamidol