Surveillance of transmitted resistance to antiretroviral drug classes among young children in the Western Cape Province of South Africa.
There are limited data on transmitted antiretroviral resistance in young children who require antiretroviral therapy. We adapted the World Health Organization surveillance strategy, testing antiretroviral naive infants (<18 months) in the Western Cape Province of South Africa, and detecting only 3 non-nucleoside reverse transcriptase inhibitors (NNRTI) and no NRTI or protease inhibitor surveillance mutations in 49 patients. The estimated NRTI and protease inhibitor transmitted antiretroviral resistance prevalence is low (<5%), predicting good therapeutic response in Western Cape infants.
van Zyl
Gert U
GU
Division of Medical Virology, Stellenbosch University, Tygerberg, South Africa. guvz@sun.ac.za.
Cotton
Mark F
MF
Claassen
Mathilda
M
Abrahams
Charmaine
C
Preiser
Wolfgang
W
D019380:Anti-HIV Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral / Q000235:genetics*; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D006801:Humans; D007223:Infant; D009154:Mutation; D011159:Population Surveillance / Q000379:methods; D015995:Prevalence; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*; D013019:South Africa / Q000453:epidemiology; D014944:World Health Organization
D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors