title: Mortality risk score in primary prevention implantable cardioverter defibrillator recipients with non-ischaemic or ischaemic heart disease.
abstract: OBJECTIVE
  To assess survival and to construct a baseline mortality risk score in primary prevention implantable cardioverter defibrillator (ICD) patients with non-ischaemic or ischaemic heart disease.
  
  
  RESULTS
  Since 1996, data of all consecutive patients who received an ICD system in the Leiden University Medical Center were collected and assessed at implantation. For the current study, all 1036 patients [age 63 (SD 11) years, 81% male] with a primary indication for defibrillator implantation were evaluated and followed for 873 (SD 677) days. During follow-up, 138 patients (13%) died. Non-ischaemic and ischaemic patients demonstrated similar survival but exhibited different factors that influence risk for mortality. A risk score, consisting of simple baseline variables could stratify patients in low, intermediate, and high risk for mortality. In non-ischaemic patients, annual mortality was 0.4% (95% CI 0.0-2.2%) in low risk and 9.4% (95% CI 6.6-13.1%) in high risk patients. In ischaemic patients, mortality was 1.0% (95% CI 0.2-3.0%) in low risk and 17.8% (95% CI 13.6-22.9%) in high risk patients.
  
  
  CONCLUSIONS
  Utilization of an easily applicable baseline risk score can create an individual patient-tailored estimation on mortality risk to aid clinicians in daily practice.
authors.affiliation: Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, The Netherlands.
authors.forename: C Jan Willem
authors.initials: CJ
authors.lastname: Borleffs
authors.forename: Guido H
authors.initials: GH
authors.lastname: van Welsenes
authors.forename: Rutger J
authors.initials: RJ
authors.lastname: van Bommel
authors.forename: Enno T
authors.initials: ET
authors.lastname: van der Velde
authors.forename: Jeroen J
authors.initials: JJ
authors.lastname: Bax
authors.forename: Lieselot
authors.initials: L
authors.lastname: van Erven
authors.forename: Hein
authors.initials: H
authors.lastname: Putter
authors.forename: Johanna G
authors.initials: JG
authors.lastname: van der Bom
authors.forename: Frits R
authors.initials: FR
authors.lastname: Rosendaal
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Schalij
mesh_terms: D000368:Aged; D002423:Cause of Death; D017147:Defibrillators, Implantable; D004452:Echocardiography; D005260:Female; D006331:Heart Diseases / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000401:mortality; D011322:Primary Prevention; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D017180:Tachycardia, Ventricular / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*