title: Computational models in plant-pathogen interactions: the case of Phytophthora infestans.
abstract: BACKGROUND
  Phytophthora infestans is a devastating oomycete pathogen of potato production worldwide. This review explores the use of computational models for studying the molecular interactions between P. infestans and one of its hosts, Solanum tuberosum.
  Deterministic logistics models have been widely used to study pathogenicity mechanisms since the early 1950s, and have focused on processes at higher biological resolution levels. In recent years, owing to the availability of high throughput biological data and computational resources, interest in stochastic modeling of plant-pathogen interactions has grown. Stochastic models better reflect the behavior of biological systems. Most modern approaches to plant pathology modeling require molecular kinetics information. Unfortunately, this information is not available for many plant pathogens, including P. infestans. Boolean formalism has compensated for the lack of kinetics; this is especially the case where comparative genomics, protein-protein interactions and differential gene expression are the most common data resources.
authors.affiliation: Mycology and Phytopathology Laboratory, Department of Biological Sciences, Universidad de los Andes, Bogotá, Colombia. am.pinzon196@uniandes.edu.co
authors.forename: Andrés
authors.initials: A
authors.lastname: Pinzón
authors.forename: Emiliano
authors.initials: E
authors.lastname: Barreto
authors.forename: Adriana
authors.initials: A
authors.lastname: Bernal
authors.forename: Luke
authors.initials: L
authors.lastname: Achenie
authors.forename: Andres F González
authors.initials: AF
authors.lastname: Barrios
authors.forename: Raúl
authors.initials: R
authors.lastname: Isea
authors.forename: Silvia
authors.initials: S
authors.lastname: Restrepo
mesh_terms: D019295:Computational Biology / Q000379:methods; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D023281:Genomics; D007700:Kinetics; D008962:Models, Theoretical; D055750:Phytophthora infestans / Q000378:metabolism*; D010935:Plant Diseases / Q000382:microbiology*; D025941:Protein Interaction Mapping; D015398:Signal Transduction; D012984:Software; D011198:Solanum tuberosum / Q000382:microbiology*; D013269:Stochastic Processes