Synthesis and biodistribution studies of carbohydrate derivatives radiolabeled with technetium-99m.
Three carbohydrate derivatives, MAG(3)-Gl, MAG(3)-Ga, MAG(3)-NG, were synthesized and radiolabeled in high yields. These substances were injected in health Swiss mice and their biodistribution were evaluated. Among them, (99m)Tc-MAG(3)-Ga displayed higher accumulation in hepatic tissue, due to the presence of specific receptors in the liver for this carbohydrate. Thus, the use of (99m)Tc-MAG(3)-Ga to assess hepatic function can be considered.
de Barros
André Luís Branco
AL
Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31279-901 Belo Horizonte, Minas Gerais, Brazil.
Cardoso
Valbert Nascimento
VN
Mota
Luciene das Graças
Ld
Alves
Ricardo José
RJ
D000818:Animals; D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D005998:Glycine / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics; D007553:Isotope Labeling; D008099:Liver / Q000378:metabolism; D051379:Mice; D017263:Technetium Tc 99m Mertiatide / Q000737:chemistry* / Q000493:pharmacokinetics; D014018:Tissue Distribution
D002241:Carbohydrates; C096273:N-(mercaptoacetyl)glycine; D017263:Technetium Tc 99m Mertiatide; D005998:Glycine