Pain associated with aminolevulinic acid-photodynamic therapy of skin disease.
BACKGROUND
Pain during topical aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) limits the use of this treatment of skin diseases.


OBJECTIVE
We sought to summarize the effectiveness of interventions to reduce ALA-PDT-related pain, and to explore factors contributing to pain induction.


METHODS
A PubMed search was performed to identify all clinical PDT trials (2000-2008) that used ALA or methyl-ALA, enrolled at least 10 patients per trial, and used a semiquantitative pain scale.


RESULTS
In all, 43 articles were identified for review. Pain intensity is associated with lesion size and location and can be severe for certain diagnoses, such as plaque-type psoriasis. Results are inconsistent for the correlation of pain with light source, wavelength of light, fluence rate, and total light dose. Cooling represents the best topical intervention.


CONCLUSIONS
Pain perception differs widely between patients and can contribute to variability in the reported results.


CONCLUSIONS
Gamma-aminobutyric acid receptors, cold/menthol receptors (transient receptor potential cation channel, subfamily M, member 8), and vanilloid/capsaicin receptors (transient receptor potential cation channel, subfamily V, member 1) may be involved in pain perception during ALA-PDT and are therefore worthy of further investigation.
Warren
Christine B
CB
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Karai
Laszlo J
LJ
Vidimos
Allison
A
Maytin
Edward V
EV
D000279:Administration, Cutaneous; D000622:Aminolevulinic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D000698:Analgesia / Q000379:methods; D006801:Humans; D010146:Pain / Q000139:chemically induced / Q000209:etiology*; D059408:Pain Management; D010778:Photochemotherapy / Q000009:adverse effects*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000009:adverse effects*; D011879:Radiotherapy Dosage
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid