title: Carbamazepine but not pregabalin impairs eye control: a study on acute objective CNS side effects in healthy volunteers.
abstract: OBJECTIVE
  This prospective study compared the effects of the new antiepileptic drug (AED) pregabalin (PGB) with the established AED carbamazepine (CBZ) on eye movements and posture control.
  
  
  METHODS
  Eye movements and posture control after AED intake were studied by electrooculography and posturography in 12 healthy volunteers who received single doses of 75mg PGB and 400mg slow release CBZ in a double-blind, cross-over, randomized trial.
  
  
  RESULTS
  CBZ caused more slowing of the peak horizontal saccade (27%) than PGB (14%). For other parameters there was no statistically significant difference as compared to baseline and in the comparison of the two AEDs. CBZ and PGB, both impaired posture control but no statistically significant effect was found.
  
  
  CONCLUSIONS
  CBZ causes more commonly dizziness after intake than PGB, when given in single doses, which is reflected in objective measurements; CBZ but not PGB impaired saccadic eye movements. Electrooculography and posturography serve as an objective measure of AED CNS side effects and could be used at an early stage of drug development.
authors.affiliation: Epilepsy Center, Department of Neurology, University of Munich, Munich, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Rémi
authors.forename: Angelika
authors.initials: A
authors.lastname: Hüttenbrenner
authors.forename: Berend
authors.initials: B
authors.lastname: Feddersen
authors.forename: Soheyl
authors.initials: S
authors.lastname: Noachtar
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology; D002220:Carbamazepine / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004585:Electrooculography; D005133:Eye Movements / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D011187:Posture; D000069583:Pregabalin; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid