[DNA methyltransferases: the role in regulation of gene expression and biological processes].
Both hitone modification and DNA methylation remodulate chromatin structure and control gene expression or silence. As a main enzyme for DNA methylation, DNA methyltransferase (Dnmt) is not only associated with DNA methylation, but also links to many important biological activities, including cell proliferation, senescence and cancer development. This review focuses on structure, regulation and function in biological processes of Dnmt.
SU
Yu
Y
School of Basic Medical Sciences, Peking University, Beijing 100191, China. suyu0000@gmail.com
WANG
Xi
X
ZHU
Wei-Guo
WG
D000818:Animals; D016922:Cellular Senescence / Q000235:genetics; D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics; D019175:DNA Methylation / Q000235:genetics; D000090205:DNA Methyltransferase 3A; D015254:DNA Modification Methylases / Q000235:genetics / Q000378:metabolism*; D044127:Epigenesis, Genetic / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D000097584:DNA Methyltransferase 3B
D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A; D015254:DNA Modification Methylases; D000097584:DNA Methyltransferase 3B; C000717967:DNMT3A protein, human; C112218:TRDMT1 protein, human