Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton.
Unexpected substituent on the well-known morphine skeleton is described to be account for highly selective and potent mu opioid ligands, which is strongly connected to substituted aromatic groups on this omitted 8alpha-position.
Li
Wei
W
Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China.
Tao
Yi-Min
YM
Tang
Yun
Y
Xu
Xue-Jun
XJ
Chen
Jie
J
Fu
Wei
W
Wang
Xing-Hai
XH
Chao
Bo
B
Sheng
Wei
W
Xie
Qiong
Q
Qiu
Zhui-Bai
ZB
Liu
Jing-Gen
JG
D018360:Crystallography, X-Ray; D006801:Humans; D008024:Ligands; D008968:Molecular Conformation; D009020:Morphine / Q000737:chemistry*; D011485:Protein Binding; D017450:Receptors, Opioid, mu / Q000378:metabolism*; D013797:Thebaine / Q000737:chemistry
D008024:Ligands; D017450:Receptors, Opioid, mu; D013797:Thebaine; D009020:Morphine