title: Association of biochemical hyperandrogenism with type 2 diabetes and obesity in Chinese women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate the effect of hyperandrogenism on metabolic disorders among patients with polycystic ovary syndrome (PCOS) diagnosed using the Rotterdam criteria.
  
  
  METHODS
  A retrospective analysis of the clinical records of 883 women with PCOS and 717 premenopausal controls identified from the general population.
  
  
  RESULTS
  A total of 686 (77.7%) patients were classified with PCOS based on National Institutes of Health (NIH) criteria, and 164 out of 197 (83.2%) additional patients had no hyperandrogenism. Women with normal androgen levels exhibited lower frequencies of obesity, type 2 diabetes, acanthosis nigricans, genetic history of diabetes, and elevated Matsuda index compared with hyperandrogenic patients. Hyperandrogenemia, but not hirsutism, was independently associated with the risk for type 2 diabetes (odds ratio [OR] 5.7; P=0.028) and obesity (OR 1.7; P=0.005) among Chinese patients with PCOS.
  
  
  CONCLUSIONS
  Hyperandrogenemia is associated with type 2 diabetes and obesity in Chinese women with PCOS and should be considered at first-line management of hyperandrogenism and infertility due to PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Xiaomiao
authors.initials: X
authors.lastname: Zhao
authors.forename: Junmin
authors.initials: J
authors.lastname: Zhong
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Mo
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Chen
authors.forename: Yaxiao
authors.initials: Y
authors.lastname: Chen
authors.forename: Dongzi
authors.initials: D
authors.lastname: Yang
mesh_terms: D000328:Adult; D000728:Androgens / Q000097:blood*; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000453:epidemiology*; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000728:Androgens