title: Antineoplastic activities of protein-conjugated silver sulfide nano-crystals with different shapes.
abstract: In this paper, antineoplastic activities of protein-conjugated silver sulfide nano-crystals with different shapes were described in detail. Transmission electron microscope analysis demonstrated that stable and well-disperse protein-conjugated silver sulfide nano-particles, nano-rods, and nano-wires could be prepared by aqueous chemistry method. The Fourier transform infrared spectrograph analysis indicated the strong coordination between silver sulfide surfaces and -OH and -NH groups in bovine serum albumin. The antineoplastic activities of protein-conjugated silver sulfide nano-crystals were examined by cell viability analysis, optical and electron microscopy methods. The results showed that nano-particles, nano-rods and nano-wires could inhibit the proliferations of human hepatocellular carcinoma Bel-7402 cells and C6 glioma cells, and the activities were size-dependent.
authors.affiliation: College of Chemistry and Environmental Science, Henan Normal University, Xinxiang, China.
authors.forename: Hua-Jie
authors.initials: HJ
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.forename: Hua-Yan
authors.initials: HY
authors.lastname: Yang
authors.forename: Kui
authors.initials: K
authors.lastname: Wang
authors.forename: Wen-Guang
authors.initials: WG
authors.lastname: Yao
authors.forename: Kai
authors.initials: K
authors.lastname: Jiang
authors.forename: Xiao-Lan
authors.initials: XL
authors.lastname: Huang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zheng
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000473:pathology*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D018030:Silver Compounds / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D018030:Silver Compounds; D012710:Serum Albumin, Bovine; C013251:silver sulfide