title: Daphhimalenine A, a new alkaloid with an unprecedented skeleton, from Daphniphyllum himalense.
abstract: Daphhimalenine A (1), a novel alkaloid with a rearrangement C-21 skeleton, containing a unique 1-azabicyclo[5.2.1]decane ring system, was isolated from the leaves of Daphniphyllum himalense, along with biogenetically related alkaloids daphhimalenine B (2) and daphnezomine T. Their structures were established on the basis of spectroscopic data, and the absolute configuration of 1 was assigned by computational methods. A plausible biosynthetic pathway of 1 was also proposed.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: Di
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Shu-Zhen
authors.initials: SZ
authors.lastname: Mu
authors.forename: Cheng-Jian
authors.initials: CJ
authors.lastname: Tan
authors.forename: Xin
authors.initials: X
authors.lastname: Fang
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Shun-Lin
authors.initials: SL
authors.lastname: Li
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D031995:Saxifragaceae / Q000737:chemistry*
chemical_list: D000470:Alkaloids; C546480:daphhimalenine A