title: Fine mapping quantitative trait loci affecting milk production traits on bovine chromosome 6 in a Chinese Holstein population.
abstract: To fine map the previously detected quantitative trait loci (QTLs) affecting milk production traits on bovine chromosome 6 (BTA6), 15 microsatellite markers situated within an interval of 14.3 cM spanning from BMS690 to BM4528 were selected and 918 daughters of 8 sires were genotyped. Two mapping approaches, haplotype sharing based LD mapping and single marker regression mapping, were used to analyze the data. Both approaches revealed a quantitative trait locus (QTL) with significant effects on milk yield, fat yield and protein yield located in the segment flanked by markers BMS483 and MNB209, which spans a genetic distance of 0.6 cM and a physical distance of 1.5 Mb. In addition, the single marker regression mapping also revealed a QTL affecting fat percentage and protein percentage at marker DIK2291. Our fine mapping work will facilitate the cloning of candidate genes underlying the QTLs for milk production traits.
authors.affiliation: State Key Laboratory for Agrobiotechnology, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
authors.forename: Gui
authors.initials: G
authors.lastname: Mei
authors.forename: Cengceng
authors.initials: C
authors.lastname: Yin
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Ding
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics* / Q000502:physiology; D002681:China; D033481:Chromosomes, Mammalian / Q000235:genetics*; D005260:Female; D007774:Lactation / Q000235:genetics*; D008297:Male; D008892:Milk / Q000737:chemistry; D020161:Physical Chromosome Mapping / Q000662:veterinary; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable