Mometasone furoate nasal spray reduces symptoms and improves quality of life in Chinese patients with moderate to severe allergic rhinitis: a multicenter open-label study.
CONCLUSIONS
Mometasone furoate nasal spray (MFNS) can reduce the symptoms and improve quality of life in Chinese patients with moderate to severe allergic rhinitis (AR).


OBJECTIVE
To evaluate the effects of MF on symptoms and quality of life in Chinese patients with moderate to severe AR.


METHODS
In a multicenter and open-label study, 500 patients with moderate to severe AR were enrolled and received MFNS 200 microg once daily. We visited the patients four times (at baseline, and week 1, 2, and 4) to record symptom scores and the influence of AR on daytime activities and quality of sleep. The Mini Rhinoconjunctivitis Quality of Life Questionnaire (Mini-RQLQ) and the Nocturnal Rhinoconjunctivitis Quality of Life Questionnaire (NRQLQ) were used in this study.


RESULTS
Compared with the baseline, MFNS significantly reduced the total and individual symptom scores and nocturnal sleep and daytime activities scores at week 1, 2, and 4 according to the Mini-RQLQ and NRQLQ.
Zhang
Luo
L
Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Key Laboratory of Otolaryngology Head and Neck Surgery, (Capital Medical University), Ministry of Education, Beijing Institute of Otolaryngology, Beijing, China.
Xu
Geng
G
Wang
Xiangdong
X
Liu
Shixi
S
Li
Yuan
Y
Wang
Shenqing
S
Yang
Beibei
B
Zheng
Chunquan
C
Wang
Chengshuo
C
Dong
Pin
P
Lin
Ziping
Z
Zhang
Hua
H
Han
Demin
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D044466:Asian People; D002648:Child; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000068656:Mometasone Furoate; D011244:Pregnadienediols / Q000627:therapeutic use*; D011788:Quality of Life; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy* / Q000523:psychology; D012890:Sleep; D055815:Young Adult
D018926:Anti-Allergic Agents; D011244:Pregnadienediols; D000068656:Mometasone Furoate