title: Use of intravenous immunoglobulin and adjunctive therapies in the treatment of primary immunodeficiencies: A working group report of and study by the Primary Immunodeficiency Committee of the American Academy of Allergy Asthma and Immunology.
abstract: There are an expanding number of primary immunodeficiency diseases (PIDDs), each associated with unique diagnostic and therapeutic complexities. Limited data, however, exist supporting specific therapeutic interventions. Thus, a survey of PIDD management was administered to allergists/immunologists in the United States to identify current perspectives and practices. Among 405 respondents, the majority of key management practices identified were consistent with existing data and guidelines, including the provision of immunoglobulin therapy, immunoglobulin dosing and selective avoidance of live viral vaccines. Practices for which there are little specific data or evidence-based guidance were also examined, including evaluation of IgG trough levels for patients receiving immunoglobulin, use of prophylactic antibiotics and recommendations for complementary/alternative medicine. Here, variability applied to PIDD patients was identified. Differences between practitioners clinically focused upon PIDD and general allergists/immunologists were also identified. Thus, a need for expanded clinical research in PIDD to optimize management and potentially improve outcomes was defined.
authors.affiliation: Robert Wood Johnson Clinical Scholars Program, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Pierre L
authors.initials: PL
authors.lastname: Yong
authors.forename: John
authors.initials: J
authors.lastname: Boyle
authors.forename: Mark
authors.initials: M
authors.lastname: Ballow
authors.forename: Marcia
authors.initials: M
authors.lastname: Boyle
authors.forename: Melvin
authors.initials: M
authors.lastname: Berger
authors.forename: Jack
authors.initials: J
authors.lastname: Bleesing
authors.forename: Franciso A
authors.initials: FA
authors.lastname: Bonilla
authors.forename: Javier
authors.initials: J
authors.lastname: Chinen
authors.forename: Charlotte
authors.initials: C
authors.lastname: Cunninghamm-Rundles
authors.forename: Ramsay
authors.initials: R
authors.lastname: Fuleihan
authors.forename: Lois
authors.initials: L
authors.lastname: Nelson
authors.forename: Richard L
authors.initials: RL
authors.lastname: Wasserman
authors.forename: Kathleen C
authors.initials: KC
authors.lastname: Williams
authors.forename: Jordan S
authors.initials: JS
authors.lastname: Orange
mesh_terms: D000047:Academies and Institutes; D000486:Allergy and Immunology / Q000706:statistics & numerical data; D000529:Complementary Therapies / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000628:therapy*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*
chemical_list: D016756:Immunoglobulins, Intravenous