The biliprotein C-phycocyanin modulates the early radiation response: a pilot study.
This study analyzed the effects of biliprotein C-phycocyanin (C-PC) on the enzymatic antioxidant defence system in lymphocytes of nuclear power-plant workers and non-exposed controls. Changes in the protein levels of manganese super oxide dismutase (MnSOD), catalase and glutathione-S-transferase (GST) were used as markers for early biological effects of a single in vitro exposure of cells to: (i) 2Gy gamma rays; (ii) 5muM C-PC; and (iii) a combination of C-PC plus irradiation with 2Gy. The results showed that C-PC selectively stimulated the lymphocyte antioxidant defence system of occupationally exposed subjects. The activation of the antioxidant protective mechanisms as part of the early radiation response was probably related to the chronic low-dose occupational exposure. The modulating capacity of C-PC at the molecular level may be of interest for the protection of occupationally exposed persons.
Ivanova
Katia G
KG
National Center of Radiobiology and Radiation Protection, 1756 Sofia, Bulgaria.
Stankova
Katia G
KG
Nikolov
Vladimir N
VN
Georgieva
Radostina T
RT
Minkova
Kaledona M
KM
Gigova
Lili G
LG
Rupova
Ivanka T
IT
Boteva
Rayna N
RN
D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D016022:Case-Control Studies; D002374:Catalase / Q000378:metabolism*; D003131:Combined Modality Therapy; D005260:Female; D005720:Gamma Rays; D005982:Glutathione Transferase / Q000378:metabolism*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D055848:Nuclear Power Plants; D016273:Occupational Exposure; D010798:Phycocyanin / Q000494:pharmacology*; D010865:Pilot Projects; D011829:Radiation Dosage; D013482:Superoxide Dismutase / Q000378:metabolism*
D000975:Antioxidants; D010798:Phycocyanin; D002374:Catalase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase