The imprinting of biomolecular features.
This paper describes a rapid imprinting procedure that makes it possible to imprint 2 and 3 dimensional DNA morphology in less than 30 minutes. In addition a multidimensional surface containing both micron and chaotic structures was successfully imprinted with a vertical and lateral resolution of 1 and 12 nm respectively. The speed and simplicity of this technique offers significant advantages compared with other techniques using polydimethylsiloxane. Moreover the process can be performed at room temperature and the master surface does not require any pretreatment or additional release agent. A polymer imprint of a polished silicon surface using thiolene based pre-polymer doped with polyethylene glycol exhibited a surface roughness value of 0.22 nm.
Hulme
John P
JP
Gachon BioNano Research Institute, College of Engineering, Kyungwon University, 461-701, Korea.
Ann
Seong Soo
SS
D004247:DNA / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D009690:Nucleic Acid Conformation
D004247:DNA