Increased carotid intima-media thickness as a predictor of the presence and extent of abnormal myocardial perfusion in type 2 diabetes.
OBJECTIVE
Identification of asymptomatic patients with type 2 diabetes at increased risk for coronary artery disease (CAD) remains a challenge. We evaluated the potential of carotid intima-media thickness (CIMT) for prediction of abnormal myocardial perfusion in this population.


METHODS
CIMT and SPECT myocardial perfusion imaging were assessed in 98 asymptomatic patients with type 2 diabetes. An increased CIMT was defined as > or =75th percentile of reference values. RESULTS Increased CIMT was an independent predictor of the extent of abnormal perfusion (P < 0.001). In patients with increased CIMT as compared with patients with normal CIMT, abnormal perfusion (75 vs. 9%) and severely abnormal perfusion (28 vs. 3%) were observed more frequently.


CONCLUSIONS
Increased CIMT was significantly related to the presence and extent of abnormal myocardial perfusion. Assessment of CIMT may be useful to identify asymptomatic patients with type 2 diabetes at higher risk for CAD.
Djaberi
Roxana
R
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Schuijf
Joanne D
JD
Jukema
J Wouter
JW
Rabelink
Ton J
TJ
Stokkel
Marcel P
MP
Smit
Jan W
JW
de Koning
Eelco J
EJ
Bax
Jeroen J
JJ
D002339:Carotid Arteries / Q000000981:diagnostic imaging* / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D055414:Myocardial Perfusion Imaging; D012307:Risk Factors; D017539:Tunica Intima / Q000000981:diagnostic imaging* / Q000473:pathology*; D017540:Tunica Media / Q000000981:diagnostic imaging* / Q000473:pathology*; D014463:Ultrasonography