[A simple method of synthesis of triterpene glycosides similar to glycyrrhizic acid and their hepatoprotective activity in vitro].
A simplified method of synthesis of triterpene l,2-trans-glycosides was developed using the glycosylation of glycyrrhetic acid (GLA) and 18,19-dehydro-GLA by beta-pyranose peracetates in the presence of SnCl(4) and molecular sieves 4 A. The synthesized glycosides exhibited hepatoprotective activity toward the human hepatoma HepG2 cell line on the model of alcohol hepatitis and decreased the level of TNF-alpha protein.
Mikhailova
L R
LR
Institute of Organic Chemistry, Ufa Research Center, Russian Academy of Sciences, Ufa, Bashkortostan, Russia.
Baltina
L A
LA
Baltina
L A
LA
Kondratenko
R M
RM
Nepogodiev
S A
SA
Field
R A
RA
Kunert
O
O
Yin
M Ch
MCh
D045744:Cell Line, Tumor; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D019695:Glycyrrhizic Acid; D006519:Hepatitis, Alcoholic / Q000188:drug therapy*; D022781:Hepatocytes / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008954:Models, Biological; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D006027:Glycosides; D014315:Triterpenes; D014409:Tumor Necrosis Factor-alpha; D019695:Glycyrrhizic Acid