title: Skin necrosis after calcium hydroxylapatite injection into the glabellar and nasolabial folds.
abstract: Calcium hydroxylapatite-induced skin necrosis occurred in 2 patients after injection in the glabella and the nasolabial fold, respectively. Supportive treatment with oral steroids, nitroglycerin paste, and warm compresses was initiated more than 48 hours after injection, and its role in recovery is uncertain. Both patients underwent microdermabrasion and used hydrocortisone ointment to flatten the scar, which resulted in gradual improvement with a reasonable cosmetic outcome 4 months after injection. This is the first report of calcium hydroxylapatite-induced skin necrosis. Injectors should be aware of this potential adverse event and counsel their patients appropriately.
authors.affiliation: Center for Facial Appearances, Salt Lake City, Utah, USA. dan.oculoplastics@gmail.com
authors.forename: Dan
authors.initials: D
authors.lastname: Georgescu
authors.forename: Yian
authors.initials: Y
authors.lastname: Jones
authors.forename: John D
authors.initials: JD
authors.lastname: McCann
authors.forename: Richard L
authors.initials: RL
authors.lastname: Anderson
mesh_terms: D001672:Biocompatible Materials / Q000009:adverse effects*; D003879:Dermatologic Agents / Q000009:adverse effects*; D017886:Durapatite / Q000009:adverse effects*; D005260:Female; D005546:Forehead; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D009666:Nose; D013508:Ophthalmologic Surgical Procedures; D012060:Rejuvenation; D012867:Skin / Q000473:pathology*; D015595:Skin Aging / Q000187:drug effects*
chemical_list: D001672:Biocompatible Materials; D003879:Dermatologic Agents; D017886:Durapatite