Inverse relationship between serum high density lipoprotein and negative syndrome in antipsychotic-naive schizophrenia.
BACKGROUND
Recent literature suggests a role for apolipoprotein L (apoL) aberrations in the pathogenesis of schizophrenia. ApoL is almost exclusively associated with apolipoprotein A-I in high-density lipoproteins (HDLs). The objective of this study was to examine the correlation between symptom scores and serum HDL in antipsychotic-naive schizophrenia patients.


METHODS
In this cross-sectional study, 60 antipsychotic-naive schizophrenia patients were systematically examined for their symptom scores, with good inter-rater reliability. Concurrently, an overnight fasting serum lipid profile from these patients was assessed.


RESULTS
Serum HDL had a significant inverse correlation with a total negative syndrome score (rho=-0.43; p=0.001).


CONCLUSIONS
The study observation supports the potential role for HDL abnormalities in the genesis of negative symptoms in schizophrenia.
Venkatasubramanian
Ganesan
G
The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India. venkat.nimhans@yahoo.com
Arasappa
Rashmi
R
Rao
Naren P
NP
Behere
Rishikesh V
RV
Kalmady
Sunil
S
Gangadhar
Bangalore N
BN
D000328:Adult; D000075944:Apolipoprotein L1; D001053:Apolipoproteins / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis
C108666:APOL1 protein, human; D000075944:Apolipoprotein L1; D001053:Apolipoproteins; D008075:Lipoproteins, HDL