Dengue virus infections and maternal antibody decay in a prospective birth cohort study of Vietnamese infants.
Dengue hemorrhagic fever can occur in primary dengue virus (DENV) infection of infants. The decay of maternally derived DENV immunoglobulin (Ig) G and the incidence of DENV infection were determined in a prospectively studied cohort of 1244 Vietnamese infants. Higher concentrations of total IgG and DENV-reactive IgG were found in cord plasma relative to maternal plasma. Maternally derived DENV-neutralizing and E protein-reactive IgG titers declined to below measurable levels in >90% of infants by 6 months of age. In contrast, IgG reactive with whole DENV virions persisted until 12 months of age in 20% of infants. Serological surveillance identified 10 infants with asymptomatic DENV infection for an incidence of 1.7 cases per 100 person-years. DENV-neutralizing antibodies remained measurable for > or = 1 year after infection. These results suggest that whereas DENV infection in infants is frequently subclinical, there is a window between 4 and 12 months of age where virion-binding but nonneutralizing IgG could facilitate antibody-dependent enhancement.
Chau
Tran Nguyen Bich
TN
Oxford University Clinical Research Unit, Hong Vuong Hospital, Ho Chi Minh City, Vietnam.
Hieu
Nguyen Trong
NT
Anders
Katherine L
KL
Wolbers
Marcel
M
Lien
Le Bich
le B
Hieu
Lu Thi Minh
LT
Hien
Tran Tinh
TT
Hung
Nguyen Thanh
NT
Farrar
Jeremy
J
Whitehead
Stephen
S
Simmons
Cameron P
CP
D000367:Age Factors; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D015331:Cohort Studies; D003716:Dengue Virus / Q000276:immunology*; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000097:blood*; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D019595:Severe Dengue / Q000453:epidemiology*; D014744:Vietnam
D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D007074:Immunoglobulin G