MeMotif: a database of linear motifs in alpha-helical transmembrane proteins.
Membrane proteins are important for many processes in the cell and used as main drug targets. The increasing number of high-resolution structures available makes for the first time a characterization of local structural and functional motifs in alpha-helical transmembrane proteins possible. MeMotif (http://projects.biotec.tu-dresden.de/memotif) is a database and wiki which collects more than 2000 known and novel computationally predicted linear motifs in alpha-helical transmembrane proteins. Motifs are fully described in terms of several structural and functional features and editable. Motifs contained in MeMotif can be used in different biological applications, from the identification of biochemically important functional residues which are candidates for mutagenesis experiments to the improvement of tools for transmembrane protein modeling.
Marsico
Annalisa
A
Bioinformatics Department, Biotechnology Center, TU Dresden, Tatzberg 47/49, 01307 Dresden, Germany. annalisa@biotec.tu-dresden.de
Scheubert
Kerstin
K
Tuukkanen
Anne
A
Henschel
Andreas
A
Winter
Christof
C
Winnenburg
Rainer
R
Schroeder
Michael
M
D020816:Amino Acid Motifs; D001426:Bacterial Proteins / Q000737:chemistry; D019295:Computational Biology / Q000379:methods* / Q000639:trends; D030541:Databases, Genetic; D030561:Databases, Nucleic Acid; D030562:Databases, Protein; D016247:Information Storage and Retrieval / Q000379:methods; D020407:Internet; D008565:Membrane Proteins / Q000737:chemistry*; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D012984:Software
D001426:Bacterial Proteins; D008565:Membrane Proteins