title: Synthesis of poly(aspartimide)-based bio-glycoconjugates.
abstract: The purpose of this programme was to synthesize and analyze new bioconjugates of interest for the potential inhibition of the influenza virus, using poly(aspartimide) as a polymer support. The macromolecular targets were obtained by attaching various sialic acid-linker-amine compounds to poly(aspartimide). (1)H and (13)C NMR studies were then performed to analyze the degree of incorporation of the sialic acid-linker-amine compounds within the poly(aspartimide). These studies illustrated that the incorporation was dependent on the nature of the spacer between the sugar and the amine functionality. Thus aliphatic spacers favoured the inclusion of sialic acid onto the polymer support whereas compounds having only an aromatic moiety between the sialic acid and the amine could not be easily incorporated.
authors.affiliation: Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, Gh. Asachi of Iasi, Technical University, Bd. D. Mangeron 71A, 700050 Iasi, Romania.
authors.forename: Irina
authors.initials: I
authors.lastname: Carlescu
authors.forename: Helen M I
authors.initials: HM
authors.lastname: Osborn
authors.forename: Jacques
authors.initials: J
authors.lastname: Desbrieres
authors.forename: Dan
authors.initials: D
authors.lastname: Scutaru
authors.forename: Marcel
authors.initials: M
authors.lastname: Popa
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D015195:Drug Design; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D019158:N-Acetylneuraminic Acid / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D006001:Glycoconjugates; D011108:Polymers; D014867:Water; D001224:Aspartic Acid; C075871:aspartimide; D019158:N-Acetylneuraminic Acid