Lambda-prophage induction modeled as a cooperative failure mode of lytic repression.
We analyze a system-level model for lytic repression of lambda phage in E. coli using reliability theory, showing that the repressor circuit comprises four redundant components whose failure mode is prophage induction. Our model reflects the specific biochemical mechanisms involved in regulation, including long-range cooperative binding, and its detailed predictions for prophage induction in E. coli under ultraviolet radiation are in good agreement with experimental data.
Chia
Nicholas
N
Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, Illinois 61801, USA.
Golding
Ido
I
Goldenfeld
Nigel
N
D010582:Bacteriophage lambda / Q000502:physiology*; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism; D004307:Dose-Response Relationship, Radiation; D004926:Escherichia coli / Q000166:cytology / Q000235:genetics / Q000378:metabolism / Q000821:virology; D008954:Models, Biological; D014466:Ultraviolet Rays; D014775:Virus Activation / Q000528:radiation effects
D004269:DNA, Bacterial