Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs.
As part of ongoing studies in developing new antimicrobials, a class of structurally novel 4-thiazolidinone derivatives incorporating three known bioactive nuclei such as thiazole, thiazolidinone and adamantane was synthesized by the multi-step reaction protocol, already reported in the literature. NMR and Molecular Modeling techniques were employed for structure elucidation and Z/E potential isomerism configuration of the analogues. Evaluation of antibacterial and antifungal activity showed that almost all compounds exhibited better results than reference drugs thus they could be promising candidates for novel drugs.
Omar
Kouatli
K
Department of Pharmaceutical Chemistry of Aristotle, School of Pharmacy, University of Thessaloniki, Thessaloniki, Greece.
Geronikaki
Athina
A
Zoumpoulakis
Panagiotis
P
Camoutsis
Charalabos
C
Soković
Marina
M
Cirić
Ana
A
Glamoclija
Jasmina
J
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007536:Isomerism; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013844:Thiazoles