title: Functional polymorphism of cytotoxic T-lymphocyte antigen 4 and nasopharyngeal carcinoma susceptibility in a Chinese population.
abstract: Cytotoxic T-lymphocyte antigen 4 (CTLA-4; CD152) is a secondary receptor of B7 (CD80 and CD86) and shares homology with the CD28 receptor. Although the structures of CTLA-4 and CD28 are very similar, they deliver different costimulatory signals. A functional polymorphism in CTLA-4 exon 1 position +49 that can affect the T-cell response has been reported by several groups. Previous case-control studies also revealed this polymorphism contribute to the risk of autoimmune diseases and common cancers. However, the relationship between CTLA-4 functional polymorphism and nasopharyngeal carcinoma (NPC) susceptibility has not yet been explored. In this study, we performed a case-control study in a Chinese population. Our result showed that the CTLA-4 +49 A>G polymorphism is associated with NPC susceptibility. The subjects carrying the CTLA-4 +49 AA genotype have a approximately 1.8-fold increased risk of NPC (adjust OR 1.83; 95% CI, 1.16-2.93) when compared with the GG genotype.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital, ZheJiang University, HangZhou, China.
authors.forename: M
authors.initials: M
authors.lastname: Xiao
authors.forename: F
authors.initials: F
authors.lastname: Qi
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: Z
authors.initials: Z
authors.lastname: Luo
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: C
authors.initials: C
authors.lastname: Zheng
authors.forename: S
authors.initials: S
authors.lastname: Hu
authors.forename: X
authors.initials: X
authors.lastname: Jiang
authors.forename: M
authors.initials: M
authors.lastname: Zhou
authors.forename: J
authors.initials: J
authors.lastname: Tang
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D015703:Antigens, CD / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D060908:CTLA-4 Antigen; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human