title: [Synthesis and biological activity of complexes of sulfonate-containing polyanions and gentamycin].
abstract: A series of copolymers of acrylamide (Am) with 2-acrylamido-2-methylpropanesulfonic acid (AmMPSA) and N-2-hydroxypropyl-methacrylamide (HPMA) with acrylic acid (AA) have been synthesized. Complexes of gentamycin in the base form with these polymers and dextran sulfate were obtained. It is established that both poly(AmMPCA) and its complex with gentamycin exhibit an antiviral activity in vitro against human A(H3N2) influenza virus and herpes simplex virus of type 1 (HSV-1). The HPMA-AA copolymer and its complex with gentamycin are only active against HSV-1. Complexes of gentamycin with the polyanions based on the Am derivatives and dextran sulfate showed a high level of antibacterial activity against four bacterial strains. All the polymers studied as well as their complexes with gentamycin demonstrated a low toxicity in vitro, which makes them promising for the creation of preparations with combined antiviral and antimicrobial properties.
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Eropkin
authors.forename: M V
authors.initials: MV
authors.lastname: Solovskiĭ
authors.forename: O M
authors.initials: OM
authors.lastname: Tikhomirova
authors.forename: T S
authors.initials: TS
authors.lastname: Briazzhikova
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Smirnova
authors.forename: E M
authors.initials: EM
authors.lastname: Eropkina
authors.forename: T S
authors.initials: TS
authors.lastname: Smirnova
mesh_terms: D000180:Acrylic Resins / Q000494:pharmacology*; D000476:Alkanesulfonates / Q000494:pharmacology*; D000838:Anions; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D005839:Gentamicins / Q000494:pharmacology*; D006561:Herpes Simplex / Q000188:drug therapy* / Q000378:metabolism; D018259:Herpesvirus 1, Human; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype; D007251:Influenza, Human / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000180:Acrylic Resins; D000476:Alkanesulfonates; D000838:Anions; D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D005839:Gentamicins; C006903:carbopol 940