Regulation of angiogenesis by ETS transcription factors.
Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally, we discuss novel evidence that shows how these transcription factors act in a combinatorial fashion with others, through composite sites that may be crucial in determining endothelial specificity in gene transcription.
Randi
Anna M
AM
National Heart and Lung Institute (NHLI) Cardiovascular Sciences Unit, Hammersmith Hospital, Imperial College London, London W12 0NN, UK. a.randi@imperial.ac.uk
Sperone
Andrea
A
Dryden
Nicola H
NH
Birdsey
Graeme M
GM
D000818:Animals; D004730:Endothelium, Vascular / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010802:Phylogeny; D011485:Protein Binding; D050783:Proto-Oncogene Proteins c-ets / Q000145:classification / Q000235:genetics / Q000378:metabolism*
D050783:Proto-Oncogene Proteins c-ets