title: Rotavirus infections with multiple emerging genotypes in Sri Lanka.
abstract: Rotavirus diarrhea is an important cause of child mortality in developing countries, but studies on this diarrhea are scarce in Sri Lanka. A prospective study conducted in Sri Lanka on rotavirus infection among children in a hospital setting (n = 611) versus children residing in tsunami camps (n = 52) showed that prevalence of rotavirus infection was comparable, 21.9 and 20%, respectively. The hospital and camps were located in different districts. Analysis of the genotypes of 122 rotaviruses from the hospital and 12 from the camps indicated that G9P[8] was associated with 35 and 33%; G12P[8/nt] with 14.7 and 33%; G3P[8/4/nt] with 17 and 8% and G1P[8/4] with 6.5 and 16.7%. Rotaviruses with G2P[8/4/6] and G4P[8/4] were hospital-associated only, and some rotaviruses (9 and 8% from the hospital and the camps, respectively) were G- and P-nontypable. We conclude from the present study that multiple emerging genotypes were prevalent in Sri Lanka, and children in camps were at risk of developing diarrhea due to rotaviruses.
authors.affiliation: Division of Infectious Diseases, Department of Social and Environmental Medicine, Institute of Scientific Research, Oita University, Yufu 879-5593, Oita, Japan. ahmed@med.oita-u.ac.jp
authors.forename: Kamruddin
authors.initials: K
authors.lastname: Ahmed
authors.forename: Ranjith
authors.initials: R
authors.lastname: Batuwanthudawe
authors.forename: T G A Nilmini
authors.initials: TG
authors.lastname: Chandrasena
authors.forename: Marcelo Takahiro
authors.initials: MT
authors.lastname: Mitui
authors.forename: Shaman
authors.initials: S
authors.lastname: Rajindrajith
authors.forename: Geethani
authors.initials: G
authors.lastname: Galagoda
authors.forename: Sher Bahadur
authors.initials: SB
authors.lastname: Pun
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Uchida
authors.forename: Osamu
authors.initials: O
authors.lastname: Kunii
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Moji
authors.forename: Nihal
authors.initials: N
authors.lastname: Abeysinghe
authors.forename: Akira
authors.initials: A
authors.lastname: Nishizono
authors.forename: Osamu
authors.initials: O
authors.lastname: Nakagomi
mesh_terms: D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000821:virology*; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D011446:Prospective Studies; D012401:Rotavirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification* / Q000502:physiology; D012400:Rotavirus Infections / Q000821:virology*; D013188:Sri Lanka; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins