A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro.
A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B*5701-related effect or other functional variants in the haplotype or both.
Yoon
Woohyun
W
Center for Human Genome Variation, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA.
Ma
Ben-Jiang
BJ
Fellay
Jacques
J
Huang
Wei
W
Xia
Shi-Mao
SM
Zhang
Ruijun
R
Shianna
Kevin V
KV
Liao
Hua-Xin
HX
Haynes
Barton F
BF
Goldstein
David B
DB
D015658:HIV Infections / Q000235:genetics* / Q000821:virology; D015497:HIV-1 / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D019562:Viral Load
C080521:HCP5 long noncoding RNA, human; D015235:HLA-B Antigens; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated