Subcortical profile of memory compromise among HIV-1-infected individuals.
OBJECTIVE
To examine the hypothesis of subcortical pathologic impairment in HIV/AIDS.


METHODS
The study included 22 HIV+, 22 HIV- controls, 22 learning disordered (LD) HIV-, and 22 depressive HIV-. The groups were compared on eight WMS-III Indices.


RESULTS
Analyses revealed significantly lower scores (p < .05) in HIV+ on visual immediate memory, immediate memory, visual delayed memory, auditory delayed memory, working memory, and general memory. For all cases, HIV+ participants scored below the control group only.


CONCLUSIONS
WMS-III indices discriminated HIV+ participants from normal comparisons. Inability to find differences between HIV+ and depressive and LD groups reflects the isolation of the subcortical effect to the HIV+ group.
Schiller
Allen
A
Harvard Medical School/McLean Hospital, Belmont, Massachusetts, USA.
Foley
Jessica
J
Burns
William
W
Sellers
A L
AL
Golden
Charles
C
D000328:Adult; D000704:Analysis of Variance; D003863:Depression / Q000150:complications* / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007360:Intelligence; D007859:Learning Disabilities / Q000503:physiopathology / Q000821:virology; D008297:Male; D008569:Memory Disorders / Q000150:complications* / Q000175:diagnosis* / Q000821:virology; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D015203:Reproducibility of Results