Developmental ECM sculpting: laying it down and cutting it up.
In mammals, proteolytic remodeling of the embryonic extracellular matrix (ECM) controls morphogenesis, but the key players remain elusive. Two recent reports identify new roles for metalloproteinases belonging to the MT-MMP and ADAMTS families in branching morphogenesis and interdigital web regression.
Feinberg
Tamar
T
Division of Molecular Medicine and Genetics, Department of Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Weiss
Stephen J
SJ
D051722:ADAM Proteins / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D019521:Body Patterning; D005109:Extracellular Matrix / Q000378:metabolism*; D005121:Extremities / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D053675:Versicans / Q000378:metabolism
D053675:Versicans; D051722:ADAM Proteins