title: Repetitive transcranial magnetic stimulation over the right dorsolateral prefrontal cortex decreases valuations during food choices.
abstract: Several studies have found decision-making-related value signals in the dorsolateral prefrontal cortex (DLPFC). However, it is unknown whether the DLPFC plays a causal role in decision-making, or whether it implements computations that are correlated with valuations, but that do not participate in the valuation process itself. We addressed this question by using repetitive transcranial magnetic stimulation (rTMS) while subjects were involved in an economic valuation task involving the consumption of real foods. We found that, as compared with a control condition, application of rTMS to the right DLPFC caused a decrease in the values assigned to the stimuli. The results are consistent with the possibility that the DLPFC plays a causal role in the computation of values at the time of choice.
authors.affiliation: Humanities and Social Sciences, California Institute of Technology, Pasadena, CA, USA.
authors.forename: Mickael
authors.initials: M
authors.lastname: Camus
authors.forename: Neil
authors.initials: N
authors.lastname: Halelamien
authors.forename: Hilke
authors.initials: H
authors.lastname: Plassmann
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Shimojo
authors.forename: John
authors.initials: J
authors.lastname: O'Doherty
authors.forename: Colin
authors.initials: C
authors.lastname: Camerer
authors.forename: Antonio
authors.initials: A
authors.lastname: Rangel
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002755:Choice Behavior / Q000502:physiology*; D004558:Electric Stimulation / Q000379:methods; D005260:Female; D005518:Food Preferences / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D017397:Prefrontal Cortex / Q000502:physiology*; D013997:Time Factors; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D055815:Young Adult