title: The Proteomics Identifications database: 2010 update.
abstract: The Proteomics Identifications database (PRIDE, http://www.ebi.ac.uk/pride) at the European Bioinformatics Institute has become one of the main repositories of mass spectrometry-derived proteomics data. For the last 2 years, PRIDE data holdings have grown substantially, comprising 60 different species, more than 2.5 million protein identifications, 11.5 million peptides and over 50 million spectra by September 2009. We here describe several new and improved features in PRIDE, including the revised submission process, which now includes direct submission of fragment ion annotations. Correspondingly, it is now possible to visualize spectrum fragmentation annotations on tandem mass spectra, a key feature for compliance with journal data submission requirements. We also describe recent developments in the PRIDE BioMart interface, which now allows integrative queries that can join PRIDE data to a growing number of biological resources such as Reactome, Ensembl, InterPro and UniProt. This ability to perform extremely powerful across-domain queries will certainly be a cornerstone of future bioinformatics analyses. Finally, we highlight the importance of data sharing in the proteomics field, and the corresponding integration of PRIDE with other databases in the ProteomExchange consortium.
authors.affiliation: EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Vizcaíno
authors.forename: Richard
authors.initials: R
authors.lastname: Côté
authors.forename: Florian
authors.initials: F
authors.lastname: Reisinger
authors.forename: Harald
authors.initials: H
authors.lastname: Barsnes
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Foster
authors.forename: Jonathan
authors.initials: J
authors.lastname: Rameseder
authors.forename: Henning
authors.initials: H
authors.lastname: Hermjakob
authors.forename: Lennart
authors.initials: L
authors.lastname: Martens
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods* / Q000639:trends; D030541:Databases, Genetic; D030561:Databases, Nucleic Acid; D030562:Databases, Protein; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods; D020407:Internet; D007477:Ions; D013058:Mass Spectrometry / Q000379:methods; D017434:Protein Structure, Tertiary; D040901:Proteomics / Q000379:methods*; D012984:Software
chemical_list: D007477:Ions