Role of APC and its binding partners in regulating microtubules in mitosis.
Adenomatous polyposis coli (APC) is a multifunctional protein commonly mutated in colon cancer. APC contains binding sites for multiple proteins with diverse roles in signaling and the structural and functional organization of cells. Recent evidence suggests roles for APC and some of its binding partners in regulating microtubules in mitosis. APC localizes to three key locations in mitosis: kinetochores, the cortex and centrosomes. Here, we discuss possible mechanisms for APC function at these sites and suggest new pathways by which APC mutations promote tumorigenesis.
Bahmanyar
Shirin
S
Department of Biological Sciences and Molecular Cellular Physiology, Stanford University, Stanford, California 94305-5430, USA.
Nelson
W James
WJ
Barth
Angela I M
AI
D025601:Adenomatous Polyposis Coli Protein / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology; D004330:Drosophila; D017491:Genes, APC; D006801:Humans; D018386:Kinetochores / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism*; D008938:Mitosis / Q000502:physiology*; D009154:Mutation; D004718:Saccharomycetales
D025601:Adenomatous Polyposis Coli Protein