title: Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population.
abstract: Chromosome 22q13 region has been implicated in schizophrenia in several linkage studies. Genes within this locus are therefore promising genetic and biologic candidate genes for schizophrenia if they are expressed in the brain or predicted to have some role in brain development. A recent study reported that bromodomain-containing 1 gene (BRD1), located in 22q13, showed an association with schizophrenia in a Scottish population. Except for being a putative regulator of transcription, the precise function of BRD1 is not clear; however, expression analysis of BRD1 mRNA revealed widespread expression in mammalian brains. In our study, we explored the association of BRD1 with schizophrenia in a Japanese population (626 cases and 770 controls). In this association analysis, we first examined 10 directly genotyped single-nucleotide polymorphisms (SNPs) and 20 imputed SNPs. Second, we compared the BRD1 mRNA levels between cases and controls using lymphoblastoid cell lines (LCLs) derived from 29 cases and 30 controls. Although the SNP (rs138880) that previously has been associated with schizophrenia showed the same trend in the Japanese population, no significant association was detected between BRD1 and schizophrenia in our study. Similarly, no significant differences in BRD1 mRNA levels in LCLs were detected. Taken together, we could not strongly show that common SNPs in the BRD1 gene account for a substantial proportion of the genetic risk for schizophrenia in the Japanese population.
authors.affiliation: Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-ku, Nagoya, Aichi 466-8550, Japan. kushima.itaru@a.mbox.nagoya-u.ac.jp
authors.forename: Itaru
authors.initials: I
authors.lastname: Kushima
authors.forename: Branko
authors.initials: B
authors.lastname: Aleksic
authors.forename: Masashi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamanouchi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Ito
authors.forename: Yukako
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Toshiya
authors.initials: T
authors.lastname: Inada
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002460:Cell Line; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D051548:Histone Acetyltransferases; D056488:Histone Chaperones; D006801:Humans; D007564:Japan; D015201:Meta-Analysis as Topic; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*; D000092468:Bromodomain Containing Proteins
chemical_list: D051548:Histone Acetyltransferases; D056488:Histone Chaperones; D009687:Nuclear Proteins; C402649:BRD1 protein, human; D000092468:Bromodomain Containing Proteins