title: Acute hepatitis C and HIV coinfection.
abstract: Hepatitis C is a common infection worldwide, but acute infection is often asymptomatic and difficult to diagnose. People coinfected with HIV and hepatitis C might progress to chronic liver disease more quickly. We present a case of a man infected with HIV with sexually acquired acute hepatitis C and discuss the immunology, natural history, and epidemiology of acute hepatitis C and coinfection with HIV. Several recent reports have documented acute hepatitis C among men who have sex with men who engage in high risk sexual practices and often have concomitant genital ulcer disease. We review treatment options for the medical management of acute hepatitis C and coinfection with HIV.
authors.affiliation: Section of Infectious Disease and International Health, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA. dionne-odom@hitchcock.org
authors.forename: Jodie
authors.initials: J
authors.lastname: Dionne-Odom
authors.forename: Melissa K
authors.initials: MK
authors.lastname: Osborn
authors.forename: Henry
authors.initials: H
authors.lastname: Radziewicz
authors.forename: Arash
authors.initials: A
authors.lastname: Grakoui
authors.forename: Kimberly
authors.initials: K
authors.lastname: Workowski
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000008:administration & dosage; D000998:Antiviral Agents / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006526:Hepatitis C / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D011994:Recombinant Proteins; D012254:Ribavirin / Q000627:therapeutic use*; D019562:Viral Load
chemical_list: D044966:Anti-Retroviral Agents; D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C417083:peginterferon alfa-2b