title: Discovery of hydrolytic catalysts in a peptidocalixarene library by binding assay with a transition state analogue for the hydrolysis.
abstract: Hydrolytic catalysts were found in a peptidocalixarene library by binding assay with a transition state analogue for the hydrolysis. The rate of the reaction can be specifically enhanced up to 50-fold in the presence of the discovered catalyst.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan. hioki@ph.bunri-u.ac.jp
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hioki
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Nishimoto
authors.forename: Kota
authors.initials: K
authors.lastname: Kawaguchi
authors.forename: Miwa
authors.initials: M
authors.lastname: Kubo
authors.forename: Kenichi
authors.initials: K
authors.lastname: Harada
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Fukuyama
mesh_terms: D001665:Binding Sites; D047250:Calixarenes / Q000737:chemistry*; D002384:Catalysis; D006868:Hydrolysis; D007700:Kinetics; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry*
chemical_list: D019151:Peptide Library; D010455:Peptides; D047250:Calixarenes