title: Structural determination of prunusins A and B, new C-alkylated flavonoids from Prunus domestica, by 1D and 2D NMR spectroscopy.
abstract: Prunusins A (1) and B (2), the new C-alkylated flavonoids, have been isolated from the seed kernels of Prunus domestica. Their structures were assigned from (1)H and (13)C nuclear magnetic resonating spectra, DEPT and by correlation spectroscopy, HMQC and HMBC experiments. 3, 5, 7, 4'-Tetrahydroxyflavone (3) and 3, 5, 7-trihydroxy-8, 4'-dimethoxyflavone (4) have also been reported from this species. Both compounds (1) and (2) showed significant antifungal activity against pathogenic fungus Trichophyton simmi.
authors.affiliation: PNEC National University of Sciences and Technology, Karachi-75270, Pakistan.
authors.forename: Azhar
authors.initials: A
authors.lastname: Mahmood
authors.forename: Itrat
authors.initials: I
authors.lastname: Fatima
authors.forename: Shaheen
authors.initials: S
authors.lastname: Kosar
authors.forename: Rehana
authors.initials: R
authors.lastname: Ahmed
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
mesh_terms: D000478:Alkylation; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification; D003903:Deuterium; D047309:Flavones / Q000737:chemistry* / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D027861:Prunus / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
chemical_list: C548362:2-(4-(((3-ethylheptanoyl)oxy)methyl)phenyl)-5,8-dimethoxy-4-oxo-4H-chromen-7-yl 4-methylbenzoate; C548361:2-(4-(((3-ethylheptanoyl)oxy)methyl)phenyl)-5-methoxy-4-oxo-4H-chromen-7-yl 3-(4-methoxyphenyl)-2-propenoate; D000935:Antifungal Agents; D047309:Flavones; D005419:Flavonoids; D003903:Deuterium