title: Caged ceramide 1-phosphate analogues: synthesis and properties.
abstract: Sphingolipid phosphate analogues bearing 7-(diethylamino)coumarin (DECM) and 4-bromo-5-hydroxy-2-nitrobenzhydryl (BHNB) groups in a photolabile ester bond were synthesized. The ability of the "caged" ceramide 1-phosphate analogues to release the bioactive parent molecule upon irradiation at 400-500 nm was demonstrated by stimulation of macrophage cell proliferation.
authors.affiliation: Department of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, New York 11367-1597, USA.
authors.forename: Ravi S
authors.initials: RS
authors.lastname: Lankalapalli
authors.forename: Alberto
authors.initials: A
authors.lastname: Ouro
authors.forename: Lide
authors.initials: L
authors.lastname: Arana
authors.forename: Antonio
authors.initials: A
authors.lastname: Gómez-Muñoz
authors.forename: Robert
authors.initials: R
authors.lastname: Bittman
mesh_terms: D002518:Ceramides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D002518:Ceramides; C065576:ceramide 1-phosphate