title: Nonsteroidal anti-inflammatory drugs (NSAIDs) in the newborn - which ones?
abstract: OBJECTIVE
  To determine which nonsteroidal anti-inflammatory drugs (NSAIDs) are being used in newborns.
  
  
  METHODS
  NSAID use was examined in local neonatal units and in published literature indexed by PubMed.
  
  
  RESULTS
  Various NSAIDs are being used in newborns. Indomethacin and ibuprofen are used worldwide for closure of patent ductus arteriosus (PDA). Both have been tested in randomized clinical trials and are approved by FDA and EMEA for PDA closure in newborns. Indomethacin, but not ibuprofen is used for prevention of intraventricular hemorrhage (IVH). Ketorolac is being studied as a potential parenteral analgesic and as a topical drug for prevention of oxygen-induced retinopathy. Others are associated with severe adverse events.
  
  
  CONCLUSIONS
  NSAIDs remain as active drugs used for PDA closure and IVH prevention. Potential uses including analgesia and retinopathy prevention are currently being studied.
authors.affiliation: State University of New York Downstate Medical Center, Brooklyn, NY, USA. jaranda@downstate.edu
authors.forename: Jacob V
authors.initials: JV
authors.lastname: Aranda
authors.forename: Kay D
authors.initials: KD
authors.lastname: Beharry
authors.forename: Gloria B
authors.initials: GB
authors.lastname: Valencia
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use*; D007213:Indomethacin / Q000009:adverse effects / Q000627:therapeutic use*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy; D020910:Ketorolac / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen; D007213:Indomethacin; D020910:Ketorolac