A facile and practical synthesis of N-acetyl enamides.
A facile and practical method for the synthesis of N-acetyl alpha-arylenamides has been developed from corresponding ketoximes as the starting materials with ferrous acetate as the reducing reagent. This methodology offers mild reaction conditions, simple purification procedures, and high yields for a variety of N-acetyl enamides.
Tang
Wenjun
W
Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut 06877, USA. wenjun.tang@boehringer-ingelheim.com
Capacci
Andrew
A
Sarvestani
Max
M
Wei
Xudong
X
Yee
Nathan K
NK
Senanayake
Chris H
CH
D000085:Acetates / Q000737:chemistry; D000107:Acetylation; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry*; D005296:Ferrous Compounds / Q000737:chemistry; D006844:Hydrocarbons, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D006865:Hydrogenation; D009682:Magnetic Resonance Spectroscopy; D010091:Oximes / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature
D000085:Acetates; D000577:Amides; D005296:Ferrous Compounds; D006844:Hydrocarbons, Cyclic; D010091:Oximes; D012997:Solvents