Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly?
The principles of self-assembly and self-organization are major tenets of molecular and cellular biology. Governed by these principles, the eukaryotic nucleus is composed of numerous subdomains and compartments, collectively described as nuclear bodies. Emerging evidence reveals that associations within and between various nuclear bodies and genomic loci are dynamic and can change in response to cellular signals. This review will discuss recent progress in our understanding of how nuclear body components come together, what happens when they form, and what benefit these subcellular structures may provide to the tissues or organisms in which they are found.
Matera
A Gregory
AG
Departments of Biology and Genetics, Program in Molecular Biology and Biotechnology, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-3280, USA. matera@unc.edu
Izaguire-Sierra
Mario
M
Praveen
Kavita
K
Rajendra
T K
TK
D000818:Animals; D022003:Cell Nucleus Structures / Q000378:metabolism*; D056426:Genetic Loci; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
D009687:Nuclear Proteins