title: Role of platelet gel and calcium-coated Lactosorb membranes in healing critical calvarial defects.
abstract: We evaluated the efficacy of coating Lactosorb (Biomet Inc, Warsaw, IN) membranes with calcium hydroxyapatite in critical-size defects in rabbits. We also evaluated whether platelet gel affects calvarial bone healing.Fifteen adult New Zealand white rabbits were divided into 5 groups. Each animal underwent a surgical procedure in which 2 critical-size (15 mm) calvarial defects were created in the parietal bones. Group A was control. Group B was a control in 1 defect and Lactosorb in the other defect. Group C was treated with Lactosorb in 1 defect and Lactosorb coated with calcium hydroxyapatite in the other defect. Group D was treated with Lactosorb in 1 defect and coated Lactosorb without calcium hydroxyapatite in the other defect. Group E was treated with platelet gel in 1 defect and control in the other. The animals were killed at 1, 3, and 6 months. The bones were excised and evaluated by clinical observation, radiography, and histology.None of the defects were closed at 6 months. Defects treated with platelet gel healed in a similar fashion as control. All defects treated with a barrier (Lactosorb, Lactosorb coated, Lactosorb coated with hydroxyapatite) showed clinical, radiographic, and histologic evidence of increased healing compared with control. The addition of hydroxyapatite did not augment healing.We concluded that the healing of critical-size defects in rabbits can be augmented by the addition of Lactosorb membranes. There is no evidence that platelet gel augments the healing of critical defects in rabbits.
authors.affiliation: Division of Plastic Surgery, Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada. dannypeters1@gmail.com
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Peters
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Courtemanche
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000502:physiology; D001861:Bone Regeneration / Q000187:drug effects; D002130:Calcium Phosphates / Q000494:pharmacology; D020099:Coated Materials, Biocompatible; D005782:Gels / Q000494:pharmacology; D048091:Guided Tissue Regeneration / Q000379:methods*; D019344:Lactic Acid; D008567:Membranes, Artificial; D010294:Parietal Bone / Q000601:surgery; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011817:Rabbits
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D005782:Gels; D008567:Membranes, Artificial; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C076375:rhenanite