Human genetics illuminates the paths to metabolic disease.
Metabolic diseases represent a growing threat to world-wide public health. In general, these disorders result from the interaction of heritable factors with environmental influences. Here, I will focus on two important metabolic disorders, namely type 2 diabetes and obesity, and explore the extent to which human molecular genetic research has illuminated our understanding of their underlying pathophysiological mechanisms.
O'Rahilly
Stephen
S
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. so104@medschl.cam.ac.uk
D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D009765:Obesity / Q000235:genetics* / Q000503:physiopathology
D007328:Insulin