Circadian disruption, Per3, and human cytokine secretion.
Circadian disruption has been linked with inflammation, an established cancer risk factor. Per3 clock gene polymorphisms have also been associated with circadian disruption and with increased cancer risk. Patients completed a questionnaire and provided a blood sample prior to undergoing a colonoscopy (n = 70). Adjusted mean serum cytokine concentrations (IL-6, TNF-alpha, gamma-INF, IL-1ra, IL-1-beta, VEGF) were compared among patients with high and low scores for fatigue (Multidimensional Fatigue Inventory), depressive symptoms (Beck Depression Inventory II), or sleep disruption (Pittsburgh Sleep Quality Index), or among patients with different Per3 clock gene variants. Poor sleep was associated with elevated VEGF, and fatigue-related reduced activity was associated with elevated TNF-alpha concentrations. Participants with the 4/5 or 5/5 Per3 variable tandem repeat sequence had elevated IL-6 concentrations compared to those with the 4/4 genotype. Biological processes linking circadian disruption with cancer remain to be elucidated. Increased inflammatory cytokine secretion may play a role.
Guess
Jaclyn
J
Department of Epidemiology and Biostatistics, Cancer Prevention and Control Program, University of South Carolina, 915 Greene Street, Columbia, SC 29208, USA.
Burch
James B
JB
Ogoussan
Kisito
K
Armstead
Cheryl A
CA
Zhang
Hongmei
H
Wagner
Sara
S
Hebert
James R
JR
Wood
Patricia
P
Youngstedt
Shawn D
SD
Hofseth
Lorne J
LJ
Singh
Udai P
UP
Xie
Dawen
D
Hrushesky
William J M
WJ
D021081:Chronobiology Disorders / Q000097:blood / Q000235:genetics*; D003113:Colonoscopy; D016207:Cytokines / Q000097:blood*; D003863:Depression / Q000097:blood / Q000235:genetics; D005221:Fatigue / Q000097:blood / Q000235:genetics; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000235:genetics; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D056950:Period Circadian Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D012892:Sleep Deprivation / Q000097:blood / Q000235:genetics*; D011795:Surveys and Questionnaires; D020080:Tandem Repeat Sequences; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
D016207:Cytokines; D015850:Interleukin-6; C512644:PER3 protein, human; D056950:Period Circadian Proteins; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A