[Relation between clinical detection rates of the novel influenza virus A/H1N1 RNA in confirmed patients in Guangzhou and the disease course].
OBJECTIVE
To study the relation of the detection rates of the novel influenza virus A/H1N1 RNA in clinically confirmed patients in the 2009 pandemic with the age distribution of the patients and the disease course.


METHODS
A total of 151 clinical patients with H1N1 infection were enrolled in this study, from whom 833 dynamic throat swab samples were obtained for detecting the H1N1 RNA using real-time PCR. A statistical analysis of the age distribution was performed among the patients with different disease courses. Chi-square for trend test was used to study the correlation between the detection rates of H1N1 RNA and the time of disease onset.


RESULTS
The majority of patients were young with their ages ranging from 10 to 20 years (57.26%) and 20 to 30 years (22.18%). Chi-square for trend test revealed that the positivity rates of the throat swabs in the patients decreased with the prolongation of the disease course (chi(2)=9.784, P=0.002).


CONCLUSIONS
Most of the H1N1 patients are young within the age range of 10-30 years, and the longest disease course can exceed 10 days. The positivity rates of throat swabs from the H1N1 patients decreases with the prolongation of the disease course.
Bai
Zhi-Jun
ZJ
Guangzhou Center for Disease Control and Prevention, Guangzhou 510080, China. junewhite@163.com
Wu
Xin-Wei
XW
Wu
Ye-Jian
YJ
Li
Mei-Xia
MX
Xu
Yang
Y
Xie
Hua-Ping
HP
Chen
Yi-Yun
YY
Jian
Li-Yun
LY
Liu
Yu-Fei
YF
Li
Tie-Gang
TG
Yang
Zhi-Cong
ZC
Wang
Ming
M
DI
Biao
B
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics*; D007251:Influenza, Human / Q000453:epidemiology / Q000821:virology*; D008297:Male; D010614:Pharynx / Q000821:virology; D012367:RNA, Viral / Q000032:analysis*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055815:Young Adult
D012367:RNA, Viral