title: DDB2 (damaged-DNA binding protein 2) in nucleotide excision repair and DNA damage response.
abstract: DDB2 was identified as a protein involved in the Nucleotide Excision Repair (NER), a major DNA repair mechanism that repairs UV damage to prevent accumulation of mutations and tumorigenesis. However, recent studies indicated additional functions of DDB2 in the DNA damage response pathway. Herein, we discuss the proposed mechanisms by which DDB2 activates NER and programmed cell death upon DNA damage through its E3 ligase activity.
authors.affiliation: Department of Biochemistry and Molecular Genetics (M/C 669), Cancer Center, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Tanya
authors.initials: T
authors.lastname: Stoyanova
authors.forename: Nilotpal
authors.initials: N
authors.lastname: Roy
authors.forename: Dragana
authors.initials: D
authors.lastname: Kopanja
authors.forename: Pradip
authors.initials: P
authors.lastname: Raychaudhuri
authors.forename: Srilata
authors.initials: S
authors.lastname: Bagchi
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics; D004247:DNA / Q000235:genetics*; D004249:DNA Damage / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000235:genetics
chemical_list: C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; C117669:DDB2 protein, human; D004268:DNA-Binding Proteins; D004247:DNA; D044767:Ubiquitin-Protein Ligases; D046988:Proteasome Endopeptidase Complex