Prognostic value of a three-grade classification in primary epithelial parotid carcinoma: result of a histological review from a 20-year experience of total parotidectomy with neck dissection in a single institution.
BACKGROUND
The tumour grading of primary parotid cancers (PPCs) remains controversial.


METHODS
A 20-year standardised single centre treatment has been assessed retrospectively. The histological review of 155 consecutively treated parotid malignancies identified 96 suitable cases for univariate and multivariate survival analyses.


RESULTS
Treatment involved total parotidectomy, neck dissection and post-operative radiotherapy in, respectively, 91.7%, 83.3% and 70.4% of cases. The 5-year overall survival, disease-specific and recurrence-free survival rates were 79.4%, 83.5% and 70.8%, respectively. Univariate analysis confirmed the classical prognostic factors, i.e. age>60 years, male gender, facial palsy, hardness of the tumour, clinical stage, tumour grade, facial nerve invasion and lymph node metastases. Multivariate analysis identified a three-grade classification just after the clinical stage as the most important prognostic factor.


CONCLUSIONS
This study identifies the prognostic significance of intermediate grade tumours.
Jouzdani
Elham
E
Head and Neck Surgery Department, Gui de Chauliac Hospital, Montpellier University Hospital Center, France.
Yachouh
Jacques
J
Costes
Valérie
V
Faillie
Jean Luc
JL
Cartier
César
C
Poizat
Flora
F
Pierre
Guillemette
G
Burcia
Vincent
V
Makeieff
Marc
M
Crampette
Louis
L
Guerrier
Bernard
B
Garrel
Renaud
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection / Q000379:methods* / Q000451:nursing*; D009367:Neoplasm Staging; D010306:Parotid Gland / Q000473:pathology / Q000601:surgery*; D010307:Parotid Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D011182:Postoperative Care / Q000379:methods; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult