Lamiridosins, hepatitis C virus entry inhibitors from Lamium album.
Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC(50) 2.31 muM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.
Zhang
Hongjie
H
Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Illinois 60612, USA. zhanghj@uic.edu
Rothwangl
Katharina
K
Mesecar
Andrew D
AD
Sabahi
Ali
A
Rong
Lijun
L
Fong
Harry H S
HH
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016174:Hepacivirus / Q000187:drug effects*; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019686:Lamiaceae / Q000737:chemistry*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism
D000998:Antiviral Agents; D039823:Iridoids; C546311:lamiridosin A; C007835:geniposide; C002947:loganic acid; C059516:loganin