In situ gelation of supramolecular hydrogel for anti-tumor drug delivery.
A supramolecular injectable hydrogel was fabricated. The hydrogel was in situ gelated by the host-guest interaction between alpha-cyclodextrins (alpha-CDs) and methylated poly(ethylene glycol) grafted poly(alpha,beta-malic acid) (mPEG-g-PMA). The hydrogel was characterized by (1)NMR, XRD, DSC, TGA and SEM. The results showed that the polyrotaxanes of alpha-CDs/mPEG-g-PMA acted as physical crosslink sites in the hydrogel. Anti-tumor drug doxorubicin hydrochloride (DOX) was loaded in the hydrogel. The release and anti-tumor effect were studied in vitro. The burst release of DOX was restrained obviously. The sustaining release time lasted more than 3 d and the cell viability decreased greatly. This hydrogel is a promising injectable hydrogel for minimally invasive therapeutic drug delivery.
He
Bin
B
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China. bhe@scu.edu.cn
Zeng
Jing
J
Nie
Yu
Y
Ji
Li
L
Wang
Rui
R
Li
Yuan
Y
Wu
Yao
Y
Li
Li
L
Wang
Gang
G
Luo
Xianglin
X
Zhang
Zhirong
Z
Gu
Zhongwei
Z
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002152:Calorimetry, Differential Scanning; D045744:Cell Line, Tumor; D004337:Drug Carriers; D006801:Humans; D020100:Hydrogels; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D014961:X-Ray Diffraction
D000970:Antineoplastic Agents; D004337:Drug Carriers; D020100:Hydrogels