[Progresses in the study of fibrous dysplasia of the jaw bone].
Fibrous dysplasia (FD) is a benign bone lesion. Histologically, the replacement of the normal substance of bone by fibro-osseous connective tissue is the most distinct character. Recent research shows that fibrous dysplasia is caused by a somatic activating mutation of the Gsalpha subunit of protein G. It may involve one bone (monostotic) or multiple bones (polyostotic). Diagnosis relies on X-ray examination and pathology. The indications and extent of surgical therapy for craniofacial FD are controversial. Nonsurgical pharmacological treatments have been disappointing. This review presented the recent advances in clinical manifestations, diagnosis and treatment of FD of the jaw bones.
Chen
Fan
F
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology Peking University, Beijing, China. navy_fun@163.com
Guo
Chuan-bin
CB
D005357:Fibrous Dysplasia of Bone; D019205:GTP-Binding Protein alpha Subunits, Gs; D006801:Humans; D008336:Mandibular Diseases
D019205:GTP-Binding Protein alpha Subunits, Gs