Molecular and cellular biology of rhabdomyosarcoma.
Rhabdomyosarcoma is a group of soft-tissue sarcomas that share features of skeletal myogenesis, but show extensive heterogeneity in histology, age and site of onset, and prognosis. This review matches recent molecular data with biological features of rhabdomyosarcoma. Alterations in molecular pathways, animal models, cell of origin and potential new therapeutic targets are discussed.
De Giovanni
Carla
C
Department of Experimental Pathology, Cancer Research Section, University of Bologna, Bologna, Italy.
Landuzzi
Lorena
L
Nicoletti
Giordano
G
Lollini
Pier-Luigi
PL
Nanni
Patrizia
P
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D012208:Rhabdomyosarcoma / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D015398:Signal Transduction; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy