title: [Guidelines of treatment for non-bleeding peptic ulcer disease].
abstract: Over the past century, since the introduction of non steroidal anti-inflammatory drugs (NSAID), antacid, histamine H2-receptor antagonists (H2RA), proton pump inhibitors (PPI), and discovery of Helicobacter pylori infection, the paradigm of peptic ulcer disease has changed with marked decrease in morbidity and mortality. However, peptic ulcer disease still occupies a position as a major health problem with increase of aged population and NSAIDs usage. In daily general practice, the management of peptic ulcer disease is directed according to the presence of bleeding or not. For non-bleeding peptic ulcer disease, proper acid suppression and the correction of underlying causes such as Helicobacter pylori infection and NSAID use is the main stay of treatment. Though a complete understanding of pathophysiology and a perfect treatment strategy are still a challenge, this guideline aims to provide practical recommendations based on evidences or consensus of experts through in-depth literature review and expert meeting.
authors.affiliation: Department of Internal Medicine, The Catholic University of Korea School of Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Cheung
authors.forename: Hwoon Yong
authors.initials: HY
authors.lastname: Jung
authors.forename: Ho June
authors.initials: HJ
authors.lastname: Song
authors.forename: Sung Woo
authors.initials: SW
authors.lastname: Jung
authors.forename: Hyun Chae
authors.initials: HC
authors.lastname: Jung
mesh_terms: D000863:Antacids / Q000633:toxicity; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001729:Bismuth / Q000627:therapeutic use; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy; D016480:Helicobacter pylori; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D010437:Peptic Ulcer / Q000188:drug therapy*; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
chemical_list: D000863:Antacids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D006633:Histamine Antagonists; D054328:Proton Pump Inhibitors; D001729:Bismuth