title: In situ gelation of supramolecular hydrogel for anti-tumor drug delivery.
abstract: A supramolecular injectable hydrogel was fabricated. The hydrogel was in situ gelated by the host-guest interaction between alpha-cyclodextrins (alpha-CDs) and methylated poly(ethylene glycol) grafted poly(alpha,beta-malic acid) (mPEG-g-PMA). The hydrogel was characterized by (1)NMR, XRD, DSC, TGA and SEM. The results showed that the polyrotaxanes of alpha-CDs/mPEG-g-PMA acted as physical crosslink sites in the hydrogel. Anti-tumor drug doxorubicin hydrochloride (DOX) was loaded in the hydrogel. The release and anti-tumor effect were studied in vitro. The burst release of DOX was restrained obviously. The sustaining release time lasted more than 3 d and the cell viability decreased greatly. This hydrogel is a promising injectable hydrogel for minimally invasive therapeutic drug delivery.
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China. bhe@scu.edu.cn
authors.forename: Bin
authors.initials: B
authors.lastname: He
authors.forename: Jing
authors.initials: J
authors.lastname: Zeng
authors.forename: Yu
authors.initials: Y
authors.lastname: Nie
authors.forename: Li
authors.initials: L
authors.lastname: Ji
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Yao
authors.initials: Y
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Xianglin
authors.initials: X
authors.lastname: Luo
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Gu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002152:Calorimetry, Differential Scanning; D045744:Cell Line, Tumor; D004337:Drug Carriers; D006801:Humans; D020100:Hydrogels; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D020100:Hydrogels