Synthesis of some new S-triazine based chalcones and their derivatives as potent antimicrobial agents.
Base catalysed condensation of ketone 5 with different aldehydes give chalcones, 2.4-bis-(phenylamino)-6-[4'-{3''-(4'''-substituted phenyl/2'''-furanyl/2'''-thienyl)-2''-propenon-1''-yl}phenylamino]-s-thriazines 6a-e. These chalcones on cyclization with hydrazine hydrate in the presence of glacial acetic acid, guanidine nitrate in the presence of alkali and malononitrile in the presence of ammonium acetate give the corresponding acetylpyrazolines 7a-e, aminopyrimidines 8a-e and cyanopyridines 9a-e respectively. The products 6a-e, 7a-e, 8a-e and 9a-e were fully characterized by spectroscopic and elemental analysis and also tested for antibacterial activity.
Solankee
Anjani
A
Department of Chemistry, B.K.M.Science College, Valsad 396001, India. dranjani_solankee@yahoo.com
Kapadia
Kishor
K
Ana Cirić
Soković
Marina
M
Doytchinova
Irini
I
Geronikaki
Athina
A
D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002599:Chalcone / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry; D021281:Quantitative Structure-Activity Relationship; D013816:Thermodynamics; D014227:Triazines / Q000737:chemistry*
D000890:Anti-Infective Agents; D011720:Pyrazoles; D011725:Pyridines; D011743:Pyrimidines; D014227:Triazines; C031280:pyrazole; D002599:Chalcone; C030986:pyrimidine; C023666:pyridine