title: The effect of L-Dopa administration on pursuit ocular movements in suspected Parkinson's disease.
abstract: The objective of this study is to evaluate pursuit ocular movements (POM) by using a vision-based non-intrusive eye tracker, in patients with suspected Parkinson's disease (PD), before and after L: -Dopa administration. We studied ten patients with suspected diagnosis of idiopathic PD. We compared POM values to those of a group of normal controls (NC), and evaluated them before and after L: -Dopa administration. Unified Parkinson's Disease Rating Scale (UPDRS) motor subscores improved significantly (p = 0.001). At baseline, values of POM were lower in suspected PD patients than in NC (p = 0.01). One hour after L: -Dopa administration, POM values correlated with UPDRS motor subscore (p = 0.01). We used a recent method, a new vision-based non-intrusive eye tracker, previously described, which can be proposed as a possible tool for supporting the diagnosis of PD in association with levodopa test, as an add-on to the UPDRS score.
authors.affiliation: IRCCS Centro Neurolesi, Bonino-Pulejo, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy. silvia.marino@centroneurolesi.it
authors.forename: Silvia
authors.initials: S
authors.lastname: Marino
authors.forename: Pietro
authors.initials: P
authors.lastname: Lanzafame
authors.forename: Edoardo
authors.initials: E
authors.lastname: Sessa
authors.forename: Alessia
authors.initials: A
authors.lastname: Bramanti
authors.forename: Placido
authors.initials: P
authors.lastname: Bramanti
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D053483:Eye Movement Measurements; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D011698:Pursuit, Smooth / Q000187:drug effects* / Q000502:physiology; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa