[The role of regulatory T cells in allergic contact dermatitis].
Regulatory T cells (Treg) play a crucial role in the regulatory mechanisms of immune system. They are responsible for the induction and maintenance of immune tolerance. They are also involved in the pathogenesis of autoimmune and allergic diseases and implicated in transplant rejection and immunopathology of cancers. Treg cells constitute the population of lymphocytes heterogeneous in their phenotype. CD4+CD25+Foxp3+ cells are most important among Treg subsets. Modification of Treg actvity may be useful in the therapy of different diseases, including allergic disorders.
Krecisz
Beata
B
Instytut Medycyny Pracy im. prof. J. Nofera, Pracownia Dermatologii, Ośrodek Alergii Zawodowej i Zdrowia Srodowiskowego, Lódź. krecisz@imp.lodz.pl
Chomiczewska
Dorota
D
Kieć-Swierczyńska
Marta
M
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D017449:Dermatitis, Allergic Contact / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000187:drug effects* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*