Effect of new breakpoints proposed by Clinical and Laboratory Standards Institute in 2008 for evaluating penicillin resistance of Streptococcus pneumoniae in a Turkish University Hospital.
Clinical and Laboratory Standards Institute changed penicillin susceptibility breakpoints for Streptococcus pneumoniae in 2008. After reevaluation with new breakpoints, resistance rates decreased from 6.1% to 0.5% for nonmeningitis and increased from 6.6% to 33.3% for meningitis isolates in our hospital. This breakpoint modification is expected to reduce the inconsistency between susceptibility results and therapeutic outcomes; however, both the clinical microbiology laboratories and the clinicians should be aware of the change to interpret the susceptibility results.
Doğan
Ozlem
O
Division of Clinical Microbiology, Microbiology Department, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Gülmez
Dolunay
D
Hasçelik
Gülşen
G
D000047:Academies and Institutes; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D006785:Hospitals, University; D006801:Humans; D007755:Laboratories, Hospital; D008826:Microbial Sensitivity Tests / Q000592:standards* / Q000706:statistics & numerical data; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology / Q000627:therapeutic use; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D016896:Treatment Outcome; D014421:Turkey
D000900:Anti-Bacterial Agents; D010406:Penicillins