title: Reduced quality of life in children with gastro-oesophageal reflux disease.
abstract: OBJECTIVE
  To assess self-reported Quality of life (QoL) in children with Gastro-oesophageal reflux disease (GORD) aged 5-18 and compare this with both disease and healthy control children in a prospective consecutive sample.
  
  
  METHODS
  All children attending a tertiary paediatric gastroenterology clinic from February 2009 to May 2009 with GORD, chronic constipation and inflammatory bowel disease (IBD) were asked to complete the validated PedsQL generic QoL assessment (self-report) at their clinic appointment. The PedsQL considers physical, emotional, social and school domains and is scored from 0 to 100. Healthy children were also recruited from the same site. Groups were compared using the independent samples Student's t-test.
  
  
  RESULTS
  A total of 184 children completed the assessment [103 (56%) male, mean age 10.7 years +/- 3.3] including 40 children with GORD, 44 with chronic constipation, 59 with IBD and 41 healthy children. QoL was significantly lower in the GORD group compared with both children with IBD (74 vs. 82) and healthy children (74 vs. 84), and was comparable to that of children with chronic constipation (74 vs. 74).
  
  
  CONCLUSIONS
  Self-reported QoL in children with GORD attending a tertiary paediatric gastroenterology clinic is significantly reduced compared with both healthy children and children with IBD.
authors.affiliation: Department of Paediatric Gastroenterology, Chelsea and Westminster Hospital, London, UK. mm1305@ic.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Marlais
authors.forename: J R
authors.initials: JR
authors.lastname: Fishman
authors.forename: J
authors.initials: J
authors.lastname: Köglmeier
authors.forename: J M E
authors.initials: JM
authors.lastname: Fell
authors.forename: D J
authors.initials: DJ
authors.lastname: Rawat
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003248:Constipation; D005260:Female; D005764:Gastroesophageal Reflux / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D015212:Inflammatory Bowel Diseases; D008297:Male; D011446:Prospective Studies; D011788:Quality of Life; D011795:Surveys and Questionnaires