En bloc spondylectomy for treatment of tumor-induced osteomalacia.
En bloc spondylectomy represents a radical resection of a spinal segment most often reserved for patients presenting with a primary extradural spine tumor or a solitary metastasis in the setting of an indolent, well-controlled systemic malignancy. The authors report a case in which en bloc spondylectomy was conducted to control a metabolically active spine tumor. A 56-year-old woman, who suffered from severe tumor-induced osteomalacia, was found to have a fibroblast growth factor-23-secreting phosphaturic mesenchymal tumor in the T-8 vertebral body. En bloc resection was conducted, leading to resolution of her tumor-induced osteomalacia. This case suggests that radical spondylectomy may be beneficial in the management of metabolically or endocrinologically active tumors of the spine.
Sciubba
Daniel M
DM
Department of Neurosurgery, National Institutes of Health, Bethesda, MD, USA.
Petteys
Rory J
RJ
Shakur
Sophia F
SF
Gokaslan
Ziya L
ZL
McCarthy
Edward F
EF
Collins
Michael T
MT
McGirt
Matthew J
MJ
Hsieh
Patrick C
PC
Nelson
Clarke S
CS
Wolinsky
Jean-Paul
JP
D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010018:Osteomalacia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery*; D019651:Plastic Surgery Procedures; D013123:Spinal Fusion; D013125:Spinal Neoplasms / Q000150:complications* / Q000378:metabolism / Q000601:surgery*; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000601:surgery; D014057:Tomography, X-Ray Computed
D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23