title: Protein evolution: innovative chaps.
abstract: Mutations in proteins allow functional innovation, but can be critically destabilizing. Recent work shows how chaperonins can rescue innovative mutants, with implications for protein engineering and adaptive evolution.
authors.affiliation: FAS Center for Systems Biology Northwest Building, Rm. 431, 52 Oxford St, Harvard University, Cambridge, MA 02138, USA. dadrummond@cgr.harvard.edu
authors.forename: D Allan
authors.initials: DA
authors.lastname: Drummond
mesh_terms: D019943:Amino Acid Substitution; D018833:Chaperonins / Q000502:physiology; D019143:Evolution, Molecular; D017510:Protein Folding; D055550:Protein Stability
chemical_list: D018833:Chaperonins