The effect of long-running severe selenium-deficiency on the amount of iron and zinc in the organs of rats.
The amounts of selenium (Se), iron (Fe), and zinc (Zn) in the liver, kidney, and spleen as a function of age of rats measured using instrumental neutron activation analysis were compared between Se-deficient (SeD) rats and normal rats. The SeD model rats can live for more than 50 weeks. The effect of Se-deficinecy in rats might be weak, compared to the marked malfunction of GSH-Px. The SeD rats can be considered as a model of nonlethal chronic oxidative stress. Fluctuations of Fe and Zn in the liver of Se-deficient rats were observed. The amount of redox-relating minerals, such as Fe and Zn, in SeD rat organs is changeable depending on the age.
Matsumoto
Ken-ichiro
K
Department of Physical Chemistry, Showa Pharmaceutical University, Tokyo, Japan. matsumok@nirs.go.jp
Terada
Sachiyo
S
Ariyoshi
Marie
M
Okajo
Aya
A
Hisamatsu
Atsushi
A
Ui
Iori
I
Endo
Kazutoyo
K
D000367:Age Factors; D000818:Animals; D005260:Female; D007501:Iron / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D018384:Oxidative Stress; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000172:deficiency*; D013154:Spleen / Q000378:metabolism; D015032:Zinc / Q000378:metabolism*
D007501:Iron; D012643:Selenium; D015032:Zinc