Protein evolution: innovative chaps.
Mutations in proteins allow functional innovation, but can be critically destabilizing. Recent work shows how chaperonins can rescue innovative mutants, with implications for protein engineering and adaptive evolution.
Drummond
D Allan
DA
FAS Center for Systems Biology Northwest Building, Rm. 431, 52 Oxford St, Harvard University, Cambridge, MA 02138, USA. dadrummond@cgr.harvard.edu
D019943:Amino Acid Substitution; D018833:Chaperonins / Q000502:physiology; D019143:Evolution, Molecular; D017510:Protein Folding; D055550:Protein Stability
D018833:Chaperonins