title: Treatment of osteoporosis by long-term magnetic field with extremely low frequency in rats.
abstract: BACKGROUND
  Osteoporosis is characterised by low bone mass and structural deterioration of bone tissue. In this study, the role of long-term extremely low frequency magnetic field (ELFMF) on osteoporosis was evaluated.
  
  
  METHODS
  The experiments were performed on 45 female Sprague-Dawley rats. The rats were divided into three groups (n = 15): Group I (ovariectomy (OVX) + ELFMF exposure), Group II (ovariectomised rats did not receive any treatment) and Group III (cage-control). Six months, 50 Hz, 1.5 mT magnetic field (MF) was used on Group I and Group II. Total body images of the animals were obtained with dual-energy X-ray absorptiometry.
  
  
  RESULTS
  Bone mineral content (BMC) and bone mineral density values were increased significantly in ELFMF group, decreased in the group of OVX and not changed in cage-control. At the end of the 6 months after exposure with ELFMF, alteration in studied biochemical markers were detected significant. Bone specific alkaline phosphatase (BAP) levels were increased in ELFMF and decreased in OVX groups when compared with cage-control group. N-telopeptide levels in OVX group were significantly higher than other groups. Testosterone and cortisol levels in OVX group were significantly higher and estradiol was lower than other groups.
  
  
  CONCLUSIONS
  Our study suggests that ELFMF may be useful in the prevention and treatment of osteoporosis.
authors.affiliation: Department of Biophysics, Dicle University, Diyarbakr, Turkey. vakpolat@dicle.edu.tr
authors.forename: Veysi
authors.initials: V
authors.lastname: Akpolat
authors.forename: Mustafa Salih
authors.initials: MS
authors.lastname: Celik
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Celik
authors.forename: Nurten
authors.initials: N
authors.lastname: Akdeniz
authors.forename: Mehmet Sirac
authors.initials: MS
authors.lastname: Ozerdem
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D015519:Bone Density; D024042:Collagen Type I / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D055909:Magnetic Field Therapy; D010024:Osteoporosis / Q000097:blood / Q000628:therapy*; D010052:Ovariectomy; D010455:Peptides / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000097:blood; D013997:Time Factors
chemical_list: D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D013739:Testosterone; D004958:Estradiol; D000469:Alkaline Phosphatase; D006854:Hydrocortisone