title: [Intrathecal morphine treatment in advanced cancer pain patients].
abstract: For more than 20 years morphine for spinal analgesia in patients with refractory cancer pain has been one of the cornerstones for the management of chronic, medically intractable pain. In general, most types of cancer pain are treatable following the guideline of Cancer Pain Relief well established by the WHO. However, some patient are unable to tolerate pain only following the guideline and often suffer with side-effects from high doses of opioid and from prescribed multiple adjuvant drugs. Due to the proximity to the receptor sites, the therapeutic efficacy of intrathecal opioid application lasts longer and also reduces systemic side effects. Intrathecal drug application is cost effective and can significantly improve the quality of life in selected patients with limited life expectancy. However, an intensive training of physicians, careful patient selection, awareness of specific complications, and arrangement of social back-up medical system are essential to commence intrathecal morphine application using implantable access port. This article introduces the basic idea of intrathecal morphine therapy with implantable access port (not pumps) as cost effective, alternative therapy for cancer patient suffering from intractable pain.
authors.affiliation: Department of Anesthesiology and Pain Service, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo 135-8550.
authors.forename: Seiji
authors.initials: S
authors.lastname: Hattori
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sano
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Tanaka
authors.forename: Miyuki
authors.initials: M
authors.lastname: Yokota
mesh_terms: D000698:Analgesia / Q000379:methods*; D006801:Humans; D007278:Injections, Spinal / Q000379:methods; D009020:Morphine / Q000008:administration & dosage*; D009369:Neoplasms / Q000503:physiopathology*; D010146:Pain / Q000188:drug therapy*; D019919:Prosthesis Implantation
chemical_list: D009020:Morphine