Synthesis and stereochemical determination of batzelladine C methyl ester.
Batzelladine C (3) is a tricyclic guanidine alkaloid of unknown stereochemistry at one centre as well as unknown absolute stereochemistry. The two possible diastereoisomers of the methyl ester corresponding to this compound have been synthesised, permitting the relative and absolute stereochemistry of this compound to be assigned.
Butters
Michael
M
AstraZeneca Process R&D Avlon/Charnwood, Avlon Works, Severn Road, Hallen, Bristol BS10 7ZE, UK.
Davies
Christopher D
CD
Elliott
Mark C
MC
Hill-Cousins
Joseph
J
Kariuki
Benson M
BM
Ooi
Li-ling
LL
Wood
John L
JL
Wordingham
Stuart V
SV
D018360:Crystallography, X-Ray; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry*; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry*; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism
D004952:Esters; D006146:Guanidines; D006575:Heterocyclic Compounds, 3-Ring; C546991:batzelladine C methyl ester