title: [High prevalence of neuroleptic drug use in elderly people with dementia].
abstract: OBJECTIVE
  The management of psychological and behavioural symptoms associated with dementia frequently requires the use of neuroleptic drugs. The objective of this study was to determine the prevalence, characteristics and possible differential factors of people aged > or = 65 years with dementia who take or not neuroleptic drugs. The subgroup with Alzheimer disease was analysed.
  
  
  METHODS
  Five-hundred and fifteen patients aged > or = 65 years with dementia were prospectively evaluated. Data were collected on sociodemographic variables, type of dementia, Barthel Index (BI), Lawton Index (LI), Mini Mental State Exam (MMSE), Charlson Index, treatment with neuroleptic, antidepressants, benzodiazepines and non-benzodiazepine hypnotic-sedatives drugs, specific dementia treatments, vascular risk factors and comorbidities. The stage and severity of dementia were evaluated by the Global Deterioration Scale (GDS), creating two groups: Mild-moderate (GDS 3, 4 and 5) and severe (GDS 6 and 7) disease.
  
  
  RESULTS
  There were 364 women (70%) and 151 men, with a mean age of 81+/-6 years, of whom 10.1% were institutionalized. Two hundred and seventy patients (52.5%) had mild-moderate disease and 245 had severe disease (47.5%). Neuroleptic drugs were being taken by 233 (45.2%) patients. In the multivariate analysis, neuroleptic drug use was associated with male gender, institutionalization, worse LI scores, more severe dementia and not having heart failure. The subgroup with Alzheimer disease was associated with worse IB and not having arterial hypertension.
  
  
  CONCLUSIONS
  A high percentage of elderly patients with dementia are treated with neuroleptic drugs. There are significant differences in the prescription of neuroleptic drugs according to patient sociodemographic characteristics, severity of dementia and comorbidities.
authors.affiliation: Unidad de Atención Integral a la Enfermedad de Alzheimer y Otras Demencias, Centro Sociosanitario El Carmen, Badalona Serveis Assistencials, Badalona, Barcelona, España. ifort@bsa.cat
authors.forename: Isabel
authors.initials: I
authors.lastname: Fort
authors.forename: Francesc
authors.initials: F
authors.lastname: Formiga
authors.forename: María José
authors.initials: MJ
authors.lastname: Robles
authors.forename: Pedro
authors.initials: P
authors.lastname: Regalado
authors.forename: Daniel
authors.initials: D
authors.lastname: Rodríguez
authors.forename: Elena
authors.initials: E
authors.lastname: Barranco
mesh_terms: D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D003704:Dementia / Q000188:drug therapy*; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D014150:Antipsychotic Agents