title: Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke.
abstract: OBJECTIVE
  The first genomewide association study of ischemic stroke in whites has identified multiple susceptibility loci. We confirmed this study by examining associations with ischemic stroke in a Chinese Han population.
  
  
  METHODS
  Twenty-five common variants were genotyped in a relatively large sample size including 1123 subjects with ischemic stroke cases (thrombosis stroke=716, lacunar infarction=407) and 557 normal control subjects. The association analyses were performed at both single nucleotide polymorphism and haplotype levels. False discovery rate q value method was applied for multiple testing corrections.
  
  
  RESULTS
  rs11052413, a intergenic single nucleotide polymorphism, was most significantly associated with ischemic stroke independent of traditional cardiovascular risk factors in additive (OR=1.51, 95% CI=1.19 to 1.92, P=7.4 x 10(-4), q=0.018) and dominant models (OR=1.59, 95% CI=1.20 to 2.08, P=9.2 x 10(-4), q=0.023). In addition, both ZNF650 rs10204475 and intergenic single nucleotide polymorphism rs10486776 were associated with ischemic stroke as well as independent of traditional cardiovascular risk factors in dominant models (OR=1.47, 95% CI=1.12 to 1.96, P=0.005, q=0.040 and OR=1.53, 95% CI=1.15 to 2.02, P=0.003, q=0.036, respectively). No significant results were found in stroke subtype analysis after multiple corrections.
  
  
  CONCLUSIONS
  Our study confirmed previously reported associations between ischemic stroke and rs11052413, rs10486776, and ZNF 650 rs10204475 in a Chinese Han population. The mechanism whereby the genetic variants exert their effects on ischemic stroke remains to be further elucidated.
authors.affiliation: Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Ding
authors.forename: Yujun
authors.initials: Y
authors.lastname: Xu
authors.forename: Xunna
authors.initials: X
authors.lastname: Bao
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Wang
authors.forename: Guanglin
authors.initials: G
authors.lastname: Cui
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Rutai
authors.initials: R
authors.lastname: Hui
authors.forename: Dao Wen
authors.initials: DW
authors.lastname: Wang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D002545:Brain Ischemia / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*