Structural investigation of biologically active phenolic compounds isolated from European tree species.
X-ray structures of two compounds isolated from wood knots of coniferous trees, namely dihydrokaempferol (3,5,8,13-tetrahydroxyflavanon) and lariciresinol (3,14-dimetoxy-7,10-epoxylignan-4,15,19-triol), are presented here. Diffraction data for the Dihydrokaempferol crystals were collected on a CAD4 diffractometer and on a synchrotron for the lariciresinol crystal. The investigated compounds inhibit lipid peroxidation and lariciresinol is additionally a good scavenger of superoxide radicals. The structural data presented in this work provide a useful basis for designing more active compounds with potential use as antioxidants.
Redzynia
Izabela
I
Institute of Technical Biochemistry, Technical University of Łódź, ul. Stefanowskiego 4/10, 90-924 Łódź, Poland. izared@p.lodz.pl
Ziółkowska
Natasza E
NE
Majzner
Wiesław R
WR
Willför
Stefan
S
Sjöholm
Rainer
R
Eklund
Patrik
P
Bujacz
Grzegorz D
GD
D028202:Abies / Q000737:chemistry*; D005060:Europe; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D059808:Polyphenols; D032107:Populus / Q000737:chemistry*; D014961:X-Ray Diffraction
D005419:Flavonoids; D005663:Furans; D017705:Lignans; D010636:Phenols; D059808:Polyphenols; C060282:lariciresinol; C080220:aromadedrin