title: Effect of aging on cellular mechanotransduction.
abstract: Aging is becoming a critical heath care issue and a burgeoning economic burden on society. Mechanotransduction is the ability of the cell to sense, process, and respond to mechanical stimuli and is an important regulator of physiologic function that has been found to play a role in regulating gene expression, protein synthesis, cell differentiation, tissue growth, and most recently, the pathophysiology of disease. Here we will review some of the recent findings of this field and attempt, where possible, to present changes in mechanotransduction that are associated with the aging process in several selected physiological systems, including musculoskeletal, cardiovascular, neuronal, respiratory systems and skin.
authors.affiliation: Cell Differentiation and Development Center, Marshall University, Huntington, WV, United States.
authors.forename: Miaozong
authors.initials: M
authors.lastname: Wu
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Fannin
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Rice
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Eric R
authors.initials: ER
authors.lastname: Blough
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001842:Bone and Bones / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D002468:Cell Physiological Phenomena; D006801:Humans; D007596:Joints / Q000502:physiology; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D018482:Muscle, Skeletal / Q000254:growth & development / Q000502:physiology; D009474:Neurons / Q000502:physiology; D012143:Respiratory Physiological Phenomena; D015398:Signal Transduction / Q000502:physiology; D012879:Skin Physiological Phenomena