title: [A case of primary adenocarcinoma of small intestine with multiple liver metastases successfully treated with mFOLFOX6].
abstract: A 60-year-old man was referred to our hospital since his stool examination was positive for occult blood. Colonoscopy showed a tumor of Bauhin's valve and terminal ileum. Biopsy of the tumor was performed and pathological examination revealed adenocarcinoma. No other lesions were detected by gastroduodenoscopy and double-balloon enteroscopy. CT also showed multiple liver metastases. Ileocecal resection was performed because of severe stenosis of the terminal ileum. Histopathological examination revealed moderately-differentiated adenocarcinoma of Bauhin's valve and the terminal ileum, and no adenocarcinoma was found in the cecum and ascending colon. He was diagnosed with primary adenocarcinoma of the ileum with multiple liver metastases. Chemotherapy with mFOLFOX6 was performed after surgical resection. After 5 courses of chemotherapy, abdominal CT showed marked regression of the liver metastases, and tumor marker (CA19-9) was normalized from 1,100 U/mL to 36 U/mL. Effectiveness of mFOLFOX6 for primary adenocarcinoma of small intestine is suggested.
authors.affiliation: Dept. of Gastroenterology, Sapporo Hokuyu Hospital.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Mitsuteru
authors.initials: M
authors.lastname: Natsuizaka
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takano
authors.forename: Mio
authors.initials: M
authors.lastname: Suzuki
authors.forename: Masako
authors.initials: M
authors.lastname: Tsuyuguchi
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Nagasako
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kawamura
authors.forename: Mineo
authors.initials: M
authors.lastname: Kudo
authors.forename: Ichirou
authors.initials: I
authors.lastname: Tsuda
authors.forename: Jyunichi
authors.initials: J
authors.lastname: Meguro
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007078:Ileal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel; D002955:Leucovorin; D005472:Fluorouracil