Use of fNIRS to assess resting state functional connectivity.
Recently, resting state functional connectivity (RSFC) studies based on fMRI and EEG/MEG have provided valuable insight into the intrinsic functional architecture of the human brain. However, whether functional near infrared spectroscopy (fNIRS), a suitable imaging method for infant and patient populations, can be used to examine RSFC remains elusive. Using an ETG-4000 Optical Topography System, the present study measured 29 adult subjects (14 females) over the sensorimotor and auditory cortexes during a resting session and a motor-localizer task session. The RSFC maps were computed by seed-based correlation analysis and data-driven cluster analysis. The results from both analyses showed robust RSFC maps, which were not only consistent with the localizer task-related activation results, but also those of previous fMRI findings. Moreover, the strong consistency between the seed-based correlation analysis and the data-driven cluster analysis further validated the use of fNIRS to assess RSFC. The potential influence of a specific low-frequency filtering range (0.04-0.15 Hz and 0.01-0.08 Hz) and three fNIRS parameters (oxy-Hb, deoxy-Hb, and total-Hb) on RSFC results were also examined.
Lu
Chun-Ming
CM
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, PR China.
Zhang
Yu-Jin
YJ
Biswal
Bharat B
BB
Zang
Yu-Feng
YF
Peng
Dan-Ling
DL
Zhu
Chao-Zhe
CZ
D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D016000:Cluster Analysis; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009044:Motor Cortex / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D009483:Neuropsychological Tests; D010108:Oxyhemoglobins / Q000378:metabolism; D012146:Rest; D012815:Signal Processing, Computer-Assisted; D013003:Somatosensory Cortex / Q000502:physiology; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D014793:Visual Cortex / Q000502:physiology; D055815:Young Adult
D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin