title: Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder.
abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1: adenylate cyclase-activating polypeptide 1) is a neuropeptide with neurotransmission modulating activity. The associations of the PACAP gene with schizophrenia and hippocampal volume have been reported. We recently reported depression-like behavior in the forced swimming test in PACAP deficient mice. Here we examined a possible association between the PACAP gene and major depressive disorder (MDD) in 637 patients and 967 controls and found that a genetic variant in the gene was associated with MDD. The present results suggest that PACAP signaling might contribute to the pathogenesis of MDD.
authors.affiliation: The Osaka-Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan. hashimor@psy.med.osaka-u.ac.jp
authors.forename: Ryota
authors.initials: R
authors.lastname: Hashimoto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Norihito
authors.initials: N
authors.lastname: Shintani
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ohi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hori
authors.forename: Osamu
authors.initials: O
authors.lastname: Saitoh
authors.forename: Asako
authors.initials: A
authors.lastname: Kosuga
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tatsumi
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.forename: Kunitoshi
authors.initials: K
authors.lastname: Kamijima
authors.forename: Akemichi
authors.initials: A
authors.lastname: Baba
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kunugi
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: C495401:ADCYAP1 protein, human; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide