Adapter and enzymatic functions of proteases in T-cell activation.
Proteases control many vital aspects of humoral and cellular immune responses, including the maturation of cytokines and the killing of target cells. Recently, it has become evident that triggering of the T-cell receptor controls T-cell proliferation through proteases such as mucosa-associated lymphoid tissue 1 (MALT1) and Caspase-8 that act both as adapters and enzymes. Here, we discuss the role of these and other proteases that are relevant to the control of the T-cell response and represent interesting targets of therapeutic immunomodulation.
Hailfinger
Stephan
S
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Rebeaud
Fabien
F
Thome
Margot
M
D048868:Adaptor Proteins, Signal Transducing / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D053181:Caspase 8 / Q000276:immunology / Q000378:metabolism*; D020169:Caspases / Q000276:immunology / Q000378:metabolism*; D049109:Cell Proliferation; D006801:Humans; D008213:Lymphocyte Activation; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; D009363:Neoplasm Proteins / Q000276:immunology / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; D009363:Neoplasm Proteins; D011948:Receptors, Antigen, T-Cell; D053181:Caspase 8; D020169:Caspases; C400109:MALT1 protein, human; D000074884:Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein