title: Antioxidative and hepatoprotective diarylheptanoids from the bark of Alnus japonica.
abstract: The present study to evaluate the potential of constituents of the bark of Alnus japonica as a functional food with medicinal properties led to the identification of one new diarylheptanoid, named alusenone (1A), and 11 known ones (1B and 2-11). Their antioxidative and hepatoprotective activities were accessed by, respectively, a TOSC assay and a TBH-induced hepatotoxicity rat model. Mixtures 1, 2-6, 10, and 11 showed good antioxidative and hepatoprotective effects as compared with the positive controls.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon, Korea.
authors.forename: Nguyen Huu
authors.initials: NH
authors.lastname: Tung
authors.forename: Sang Kyum
authors.initials: SK
authors.lastname: Kim
authors.forename: Jeong Chan
authors.initials: JC
authors.lastname: Ra
authors.forename: Yu-Zhe
authors.initials: YZ
authors.lastname: Zhao
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Sohn
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D029661:Alnus / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D036381:Diarylheptanoids / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D051381:Rats
chemical_list: D000975:Antioxidants; D036381:Diarylheptanoids