title: CXCL12/CXCR4 promotes motility and proliferation of glioma cells.
abstract: Glioblastoma (GBM) is the most aggressive and malignant brain tumor. Recent studies indicated that glioma samples are characterized by increased expression of CXCR4, the CXCL12/SDF-1 chemokine receptor. To better understand the role of CXCR4 in GBM biology we performed an integrated study where we simultaneously evaluate the contribution of the CXCR4/CXCL12 signaling pathway to the proliferation, survival and motility of a human GBM cell line. Our results indicated that CXCR4/CXCL12 axis induced an increase in cell proliferation and in cell motility. The blockage of CXCR4 induced a significant increase of apoptosis. Together, our results indicated that CXCR4/CXCL12 signalling pathway may contribute to GBM development and emphasize the therapeutic potential of this pathway in patients with GBM.
authors.affiliation: Centre for Neuroscience and Cell Biology and CIMAGO, University of Coimbra, Coimbra, Portugal. analiacarmo@gmail.com
authors.forename: Anália
authors.initials: A
authors.lastname: do Carmo
authors.forename: Inês
authors.initials: I
authors.lastname: Patricio
authors.forename: Maria T
authors.initials: MT
authors.lastname: Cruz
authors.forename: Helena
authors.initials: H
authors.lastname: Carvalheiro
authors.forename: Catarina R
authors.initials: CR
authors.lastname: Oliveira
authors.forename: Maria C
authors.initials: MC
authors.lastname: Lopes
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D054377:Chemokine CXCL12 / Q000235:genetics / Q000378:metabolism*; D002633:Chemotaxis; D005909:Glioblastoma / Q000473:pathology; D005910:Glioma / Q000235:genetics*; D006801:Humans; D019718:Receptors, CXCR4 / Q000235:genetics / Q000378:metabolism*
chemical_list: D054377:Chemokine CXCL12; D019718:Receptors, CXCR4