title: Synthesis, DNA-binding, photocleavage, cytotoxicity and antioxidant activity of ruthenium (II) polypyridyl complexes.
abstract: Two new ligands maip (1a), paip (1b) with their ruthenium (II) complexes [Ru(bpy)(2)(maip)](ClO(4))(2) (2a) and [Ru(bpy)(2)(paip)](ClO(4))(2) (2b) have been synthesized and characterized. The results show that complexes 2a and 2b interact with DNA through intercalative mode. The cytotoxicity of these compounds has been evaluated by MTT assay. The experiments on antioxidant activity show that these compounds exhibit good antioxidant activity against hydroxyl radical (OH).
authors.affiliation: School of Pharmacy, Guangdong Pharmaceutical University, Guangdong, Guangzhou 510006, PR China. lyjche@163.com
authors.forename: Yun-Jun
authors.initials: YJ
authors.lastname: Liu
authors.forename: Cheng-Hui
authors.initials: CH
authors.lastname: Zeng
authors.forename: Hong-Liang
authors.initials: HL
authors.lastname: Huang
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: He
authors.forename: Fu-Hai
authors.initials: FH
authors.lastname: Wu
mesh_terms: D000042:Absorption; D000818:Animals; D002417:Cattle; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004583:Electrons; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D017665:Hydroxyl Radical / Q000737:chemistry; D009691:Nucleic Acid Denaturation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology / Q000633:toxicity; D055668:Photochemical Processes; D011725:Pyridines / Q000737:chemistry*; D051381:Rats; D012428:Ruthenium / Q000737:chemistry*; D013057:Spectrum Analysis; D044366:Transition Temperature; D014783:Viscosity
chemical_list: D016166:Free Radical Scavengers; D009942:Organometallic Compounds; D011725:Pyridines; D017665:Hydroxyl Radical; D012428:Ruthenium; D004247:DNA; C023666:pyridine