[Metabolic correction of neurochemical disturbances in the striatum by the amino-acid-based drug tavamin on the experimental model of morphine abstinence syndrome].
We have studied the content of neuroactive amino acids in the striatum of rats under the conditions of development of the morphine abstinence syndrome, as well as the possibility of its metabolic correction by amino-acid-based drug tavamin. Peculiarities in the metabolism of glutamate, aspartate, glycine, GABA, and taurine in addicted rats and the effect of tavamin on the background of abstinence syndrome have been revealed.
Kurbat
M N
MN
Lelevich
V V
VV
Kurbat
N M
NM
D000597:Amino Acids, Branched-Chain / Q000494:pharmacology*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D003342:Corpus Striatum / Q000378:metabolism*; D008297:Male; D009021:Morphine Dependence / Q000188:drug therapy / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000378:metabolism*; D013654:Taurine / Q000494:pharmacology*
D000597:Amino Acids, Branched-Chain; D018377:Neurotransmitter Agents; D013654:Taurine