Multiparameter analysis of EEG in old wistar rats after bilateral carotid artery ligation.
We showed that 302 of 840 EEG parameters in old Wistar rats significantly change 3 h after bilateral carotid artery ligation. All animals (n=7) died 250+/-47 min after ligation. EEG power spectra had signs of suppression (increased d-activity, decreased t-activity, and increased low-frequency alpha-activity) or activation of CNS (decreased high-frequency alpha-activity and paroxysmal increase in beta-activity). The coherence, synchrony, and entropy of potentials were reduced in the majority of brain regions. This method and scheme of experiments are suitable for the search and study of anti-stroke drugs.
Kozhechkin
S N
SN
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. tunetuga@mail.ru
Koshtoyants
O Ch
OCh
Seredenin
S B
SB
D000818:Animals; D002545:Brain Ischemia / Q000209:etiology / Q000473:pathology*; D020212:Carotid Artery Injuries / Q000150:complications / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods; D008026:Ligation; D008297:Male; D051381:Rats; D017208:Rats, Wistar