Protective effects of Selenium (Se) on Chromium (VI) induced nephrotoxicity in adult rats.
Chromium is a toxic metal implicated in human diseases. This study was focused on investigating the possible protective effect of Se against K(2)Cr(2)O(7). Female Wistar rats, used in this study, were divided into four groups of six animals each: group I served as control which received standard diet; group II received orally only K(2)Cr(2)O(7) (700 ppm equivalent to 67 mg/kgbw); group III received both K(2)Cr(2)O(7) and Se (0.5 mg/kg of diet); group IV received Se (0.5mg Na(2)SeO(3)/kg of diet). The exposure of rats to K(2)Cr(2)O(7) for 21 days provoked renal damages with a significant increase in kidney malondialdehyde, superoxide dismutase, plasma creatinine, and uric acid levels, while catalase, glutathione peroxidase, non-protein thiol, Metallothionein and plasma urea levels decreased. Coadministration of Se in the diet of chromium-treated group improved malondialdehyde, renal biomarkers levels and antioxidant enzyme activities. Kidney histological studies confirmed biochemical parameters and the beneficial role of selenium.
Soudani
Nejla
N
Animal Physiology Laboratory, Life Sciences Department, UR/08-73 Sfax Faculty of Sciences, BP 1171, 3000 Sfax, Tunisia.
Sefi
Mediha
M
Ben Amara
Ibtissem
I
Boudawara
Tahia
T
Zeghal
Najiba
N
D000818:Animals; D002374:Catalase / Q000032:analysis; D002857:Chromium / Q000037:antagonists & inhibitors* / Q000633:toxicity; D003404:Creatinine / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000032:analysis; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D018384:Oxidative Stress / Q000187:drug effects*; D011192:Potassium Dichromate / Q000037:antagonists & inhibitors* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000032:analysis; D014508:Urea / Q000097:blood
D002857:Chromium; D014508:Urea; D003404:Creatinine; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium; D011192:Potassium Dichromate