title: The effects of rutin on a passive avoidance test in rats.
abstract: Various synthetic derivatives of natural flavonoids are known to have neuroactive properties. The aim of the present study was to investigate the effects of rutin (3, 3', 4', 5, 7-pentahydroxyflavone-3-rhamnoglucoside), a flavonoid that is an important dietary constituent of foods and plant-based beverages, on memory retrieval in rats. To this end, we assessed the effect of rutin on memory retrieval using a step-through passive avoidance task. Rutin (5, 10, and 100mg/kg) was administered intraperitoneally (i.p.) one week before the start of training. Three retention tests were performed to assess memory in rats. Rutin (10mg/kg) significantly increased the step-through latency of the passive avoidance response compared to the control in the three retention tests of the passive avoidance paradigm. These results indicate that rutin has a potential role in enhancing memory retrieval. Several mechanisms may contribute to the potential role of rutin in memory enhancement. This result supports the potential beneficial effects of rutin as a dietary supplement on memory retrieval in a passive avoidance task.
authors.affiliation: Department of Pharmacology, Qazvin University of Medical Sciences, Qazvin, Iran. marjannassiriaslm@gmail.com
authors.forename: Marjan
authors.initials: M
authors.lastname: Nassiri-Asl
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Zamansoltani
authors.forename: Amir
authors.initials: A
authors.lastname: Javadi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Ganjvar
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004597:Electroshock / Q000009:adverse effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D012431:Rutin / Q000494:pharmacology*
chemical_list: D012431:Rutin