RecA-independent DNA damage induction of Mycobacterium tuberculosis ruvC despite an appropriately located SOS box.
Mycobacterium tuberculosis ruvC was induced by DNA damage in a DeltarecA strain despite having an appropriately positioned SOS box to which LexA binds in vitro. An inducible transcript start mapped within the SOS box, and transcriptional fusions identified the promoter. Disruption of the SOS box did not prevent induction, indicating that an alternative mechanism plays a significant role in the control of ruvC expression.
Dawson
Lisa F
LF
MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.
Dillury
Joanna
J
Davis
Elaine O
EO
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004249:DNA Damage / Q000235:genetics* / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics / Q000502:physiology; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000378:metabolism*; D011401:Promoter Regions, Genetic / Q000235:genetics; D013014:SOS Response, Genetics / Q000235:genetics*
D001426:Bacterial Proteins