Nitrate and nitrite in biology, nutrition and therapeutics.
Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.
Lundberg
Jon O
JO
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. jon.lundberg@ki.se
Gladwin
Mark T
MT
Ahluwalia
Amrita
A
Benjamin
Nigel
N
Bryan
Nathan S
NS
Butler
Anthony
A
Cabrales
Pedro
P
Fago
Angela
A
Feelisch
Martin
M
Ford
Peter C
PC
Freeman
Bruce A
BA
Frenneaux
Michael
M
Friedman
Joel
J
Kelm
Malte
M
Kevil
Christopher G
CG
Kim-Shapiro
Daniel B
DB
Kozlov
Andrey V
AV
Lancaster
Jack R
JR
Lefer
David J
DJ
McColl
Kenneth
K
McCurry
Kenneth
K
Patel
Rakesh P
RP
Petersson
Joel
J
Rassaf
Tienush
T
Reutov
Valentin P
VP
Richter-Addo
George B
GB
Schechter
Alan
A
Shiva
Sruti
S
Tsuchiya
Koichiro
K
van Faassen
Ernst E
EE
Webb
Andrew J
AJ
Zuckerbraun
Brian S
BS
Zweier
Jay L
JL
Weitzberg
Eddie
E
D000818:Animals; D004032:Diet; D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D009566:Nitrates / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use*; D009569:Nitric Oxide / Q000378:metabolism*; D009573:Nitrites / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use*; D015398:Signal Transduction
D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide