title: Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development.
abstract: Recent observations highlight that the mammalian genome extensively communicates with itself via long-range chromatin interactions. The causal link between such chromatin cross-talk and epigenetic states is, however, poorly understood. We identify here a network of physically juxtaposed regions from the entire genome with the common denominator of being genomically imprinted. Moreover, CTCF-binding sites within the H19 imprinting control region (ICR) not only determine the physical proximity among imprinted domains, but also transvect allele-specific epigenetic states, identified by replication timing patterns, to interacting, nonallelic imprinted regions during germline development. We conclude that one locus can directly or indirectly pleiotropically influence epigenetic states of multiple regions on other chromosomes with which it interacts.
authors.affiliation: Department of Development and Genetics, Evolution Biology Centre, Uppsala University, S-752 36 Uppsala, Sweden.
authors.forename: Kuljeet Singh
authors.initials: KS
authors.lastname: Sandhu
authors.forename: Chengxi
authors.initials: C
authors.lastname: Shi
authors.forename: Mikael
authors.initials: M
authors.lastname: Sjölinder
authors.forename: Zhihu
authors.initials: Z
authors.lastname: Zhao
authors.forename: Anita
authors.initials: A
authors.lastname: Göndör
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.forename: Vijay K
authors.initials: VK
authors.lastname: Tiwari
authors.forename: Sylvain
authors.initials: S
authors.lastname: Guibert
authors.forename: Lina
authors.initials: L
authors.lastname: Emilsson
authors.forename: Marta P
authors.initials: MP
authors.lastname: Imreh
authors.forename: Rolf
authors.initials: R
authors.lastname: Ohlsson
mesh_terms: D000483:Alleles; D000818:Animals; D002478:Cells, Cultured; D053595:Embryonic Stem Cells; D005260:Female; D018507:Gene Expression Regulation, Developmental; D018392:Genomic Imprinting / Q000235:genetics*; D005854:Germ Cells / Q000254:growth & development* / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated
chemical_list: C094335:H19 long non-coding RNA; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated