title: Molecular activation of NF-kappaB, pro-inflammatory mediators, and signal pathways in gamma-irradiated mice.
abstract: The effects of gamma-irradiation on inflammatory gene expression, including NF-kappaB activation, in the kidney of C57/BL6 mice exposed to 1-9 Gy doses of (60)Co gamma-irradiation. Radiation enhanced the NF-kappaB activation and oxidative stress caused a dose-dependent disruption in the redox balance. The significance of this study is the new molecular information gained on gamma-irradiation effects through the activation of pro-inflammatory genes by NF-kappaB via the MAPK signaling pathway. Considering the exquisite sensitivity of NF-kappaB and other pro-inflammatory mediators to the redox status, we conclude that the activation of inflammatory processes by irradiation is likely initiated by increased oxidative stress.
authors.affiliation: Department of Pharmacy, Pusan National University, Busan, 609-735, Korea.
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Ha
authors.forename: Sang Woon
authors.initials: SW
authors.lastname: Chung
authors.forename: Ji Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Dae Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Eun Kyeong
authors.initials: EK
authors.lastname: Lee
authors.forename: Jaewon
authors.initials: J
authors.lastname: Lee
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Mi Ae
authors.initials: MA
authors.lastname: Yoo
authors.forename: Kyu Shik
authors.initials: KS
authors.lastname: Jeong
authors.forename: Hae Young
authors.initials: HY
authors.lastname: Chung
mesh_terms: D000818:Animals; D003037:Cobalt Radioisotopes; D004789:Enzyme Activation / Q000528:radiation effects; D005720:Gamma Rays; D019803:Glutathione Disulfide / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism / Q000528:radiation effects; D015227:Lipid Peroxidation / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000528:radiation effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000528:radiation effects*; D015854:Up-Regulation / Q000528:radiation effects; D014916:Whole-Body Irradiation / Q000379:methods*
chemical_list: D003037:Cobalt Radioisotopes; D018836:Inflammation Mediators; D016328:NF-kappa B; D017382:Reactive Oxygen Species; D020928:Mitogen-Activated Protein Kinases; D019803:Glutathione Disulfide