title: Peritoneal microdialysis. Early diagnosis of anastomotic leakage after low anterior resection for rectosigmoid cancer.
abstract: BACKGROUND
  The aim of the present study was to evaluate the efficacy and safety of intraperitoneal microdialysis in early detection of anastomotic leakage after low anterior resection for rectosigmoid cancer.
  
  
  METHODS
  In a series of 116 consecutive patients scheduled for low anterior resection for rectosigmoid cancer, a total of 50 patients consented to participate. Peritoneal microdialysis was performed by a 1 mm thin catheter anchored in close proximity to the anastomosis. Five patients were excluded due to catheter malfunction. Average microdialysis time in the remaining 45 patients was 177.6 (80-252) hours. Samples were collected every 4-hours, and the concentration of glucose, lactate, pyruvate and glycerol was measured.
  
  
  RESULTS
  Four patients developed symptomatic anastomotic leakage. Two patients developed non-abdominal sepsis. In 38 patients the postoperative course was uncomplicated, considering major complications, and they served as controls. In three patients with late (>or=10 days) anastomotic leakage a significant increase in concentration of lactate and lactate/pyruvate ratio (L/P-ratio) was seen several days prior to development of clinical symptoms. In one patient with early anastomotic leakage it coincided with the development of clinical symptoms. In the two patients with non-abdominal sepsis the values were within normal range.
  
  
  CONCLUSIONS
  Peritoneal microdialysis is a safe and promising tool in early diagnosis of anastomotic leakage after low anterior resection for rectosigmoid cancer.
authors.affiliation: Department of Surgery, Odense University Hospital, Odense C, Denmark. markep01@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Ellebaek Pedersen
authors.forename: N
authors.initials: N
authors.lastname: Qvist
authors.forename: C
authors.initials: C
authors.lastname: Bisgaard
authors.forename: U
authors.initials: U
authors.lastname: Kelly
authors.forename: A
authors.initials: A
authors.lastname: Bernhard
authors.forename: S
authors.initials: S
authors.lastname: Møller Pedersen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical / Q000009:adverse effects; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D017551:Microdialysis / Q000379:methods*; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000379:methods*; D011183:Postoperative Complications; D011237:Predictive Value of Tests; D019289:Pyruvic Acid / Q000378:metabolism; D012004:Rectal Neoplasms / Q000601:surgery*; D012811:Sigmoid Neoplasms / Q000601:surgery*
chemical_list: D019344:Lactic Acid; D019289:Pyruvic Acid