title: Prognostic value of cardiac troponin I in patients with COPD acute exacerbation.
abstract: BACKGROUND
  Chronic obstructive pulmonary disease (COPD) is frequently associated with right ventricular loading and pulmonary hypertension. We aimed to evaluate a possible association between cardiac troponin I (cTnI) levels and adverse events in hospitalised patients with acute exacerbation of COPD .
  
  
  METHODS
  Retrospective cohort study, with analysis of admissions for acute exacerbation of COPD , with cTnI obtained in the first 48 hours of admission. A positive cTnI test was defined as 0.012 ng/ml or higher (99th percentile). Baseline and peak troponin I levels were taken as independent variables, and outcome variables included length of hospital stay, complications during hospitalisation, and in-hospital and extra-hospital mortality (evaluated 18 months post-discharge).
  
  
  RESULTS
  Data concerned 173 patients (105 male, 68 female), with a median age of 77 years (interquartile range of 11 years). The median baseline cTnI was 0.030 ng/ml (n=173), and the median peak cTnI was 0.040 ng/ml (n=173; absolute peak value of 1.260 ng/ml). Nearly 70% of cases had a positive cTnI at admission. Both baseline and peak cTnI correlated significantly with the need for noninvasive ventilatory support. We were not able to find significant differences in in-hospital survival associated with the two troponin groups, but overall 18-month survival was significantly higher among patients with lower values of baseline and peak cTnI.
  
  
  CONCLUSIONS
  In patients hospitalised for acute COPD exacerbations, elevated baseline and peak cTnI were associated with a greater need for noninvasive ventilatory support and were significant predictors of 18-month overall survival.
authors.affiliation: Department of Medicine, Hospital Sao Joao, Porto, Portugal. Carlamrt@nortemedico.pt
authors.forename: C S
authors.initials: CS
authors.lastname: Martins
authors.forename: M J O
authors.initials: MJ
authors.lastname: Rodrigues
authors.forename: V P
authors.initials: VP
authors.lastname: Miranda
authors.forename: J P L
authors.initials: JP
authors.lastname: Nunes
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007902:Length of Stay; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D016017:Odds Ratio; D011174:Portugal; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000150:complications / Q000401:mortality / Q000628:therapy; D012138:Respiratory Therapy / Q000379:methods; D012189:Retrospective Studies; D019210:Troponin I / Q000097:blood*
chemical_list: D019210:Troponin I; D020097:Natriuretic Peptide, Brain