title: Central granular cell odontogenic tumor: a histopathologic and immunohistochemical study.
abstract: The central granular cell odontogenic tumor (CGCOT) is a rare lesion that usually affects the posterior region of the mandible of young adults. We present a case of CGCOT involving the mandible of a 20-year-old white woman, emphasizing the immunohistochemical characteristics using a large panel of antibodies. The lesion was removed surgically, and after 4 years of follow-up, there are no evidences of recurrences. The odontogenic epithelium (OE) showed positivity for cytokeratins (CKs) AE1/AE3, 34betaE12, CK5, CK7, CK8, CK14, CK19, E-cadherin, beta-catenin, CD138, and p63. The granular cells were positive for vimentin, CD68, lysozyme, muscle-specific actin, alpha-smooth muscle actin, calponin, neuron-specific enolase (NSE), CD138, and bcl-2. Dendritic-like cells surrounding the OE displayed positivity for vimentin, CD1a, S100, CD68, and bcl-2, but it was negative for factor XIIIa, supporting a Langerhans cell phenotype. Ki-67 labeling index was 1.8%, whereas p53 was negative. These data confirm the benign nature of CGCOT, the association of OE with Langerhans cells, and a variable phenotype of the granular cells.
authors.affiliation: Department of Dentistry, University of Diamantina, UFVJM, CEP: 39100-000 Diamantina, Minas Gerais, Brazil. hanamesquita@fop.unicamp.br
authors.forename: Ana Terezinha Marques
authors.initials: AT
authors.lastname: Mesquita
authors.forename: Cássio Roberto Rocha
authors.initials: CR
authors.lastname: Santos
authors.forename: Ricardo Santiago
authors.initials: RS
authors.lastname: Gomez
authors.forename: Jacks
authors.initials: J
authors.lastname: Jorge
authors.forename: Jorge Esquiche
authors.initials: JE
authors.lastname: León
authors.forename: Oslei Paes
authors.initials: OP
authors.lastname: de Almeida
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D018572:Disease-Free Survival; D005260:Female; D016586:Granular Cell Tumor / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008339:Mandibular Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D009808:Odontogenic Tumors / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor