Targeted hyperthermia using metal nanoparticles.
Despite the use of hyperthermia to treat cancer for thousands of years, the challenge of only heating malignant cells remains daunting. In pre-clinical and early clinical trials, metal nanoparticles induce hyperthermic cytotoxicity when exposed to near-infrared radiation or radiofrequency fields. We discuss the emerging roles of nanoparticles, especially gold, in the hyperthermic treatment of cancer. In addition, we discuss the similarities of radiofrequency ablation and nanoparticle mediated cytotoxicity.
Cherukuri
Paul
P
The Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Glazer
Evan S
ES
Curley
Steven A
SA
D017115:Catheter Ablation / Q000379:methods; D002986:Clinical Trials as Topic; D006046:Gold / Q000737:chemistry; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D053768:Metal Nanoparticles / Q000008:administration & dosage*; D036103:Nanotechnology / Q000379:methods; D009369:Neoplasms / Q000628:therapy*
D006046:Gold