title: Self-modulation of neocortical pyramidal neurons by endocannabinoids.
abstract: Control of pyramidal neuron excitability is vital for the functioning of the neocortex. Somatodendritic slow self-inhibition (SSI) allows inhibitory neurons to regulate their own activity, but the existence of similar mechanisms in excitatory cells has not been shown. We found that in rodents endocannabinoids mediated SSI and long-term modulation of inhibitory connections in layer 2/3 pyramidal neurons with a distinct dendritic morphology, suggesting that a glutamatergic network in cortical circuits is self-regulated.
authors.affiliation: European Brain Research Institute, Rome, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Marinelli
authors.forename: Simone
authors.initials: S
authors.lastname: Pacioni
authors.forename: Astrid
authors.initials: A
authors.lastname: Cannich
authors.forename: Giovanni
authors.initials: G
authors.lastname: Marsicano
authors.forename: Alberto
authors.initials: A
authors.lastname: Bacci
mesh_terms: D000818:Animals; D048588:Benzoxazines / Q000494:pharmacology; D063385:Cannabinoid Receptor Modulators / Q000378:metabolism*; D002186:Cannabinoids / Q000494:pharmacology; D003712:Dendrites / Q000502:physiology; D063388:Endocannabinoids; D018698:Glutamic Acid / Q000502:physiology; D051379:Mice; D009025:Morpholines / Q000494:pharmacology; D009281:Naphthalenes / Q000494:pharmacology; D019579:Neocortex / Q000166:cytology*; D009433:Neural Inhibition / Q000502:physiology*; D009924:Organ Culture Techniques; D018408:Patch-Clamp Techniques; D017966:Pyramidal Cells / Q000187:drug effects* / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D043884:Receptor, Cannabinoid, CB1 / Q000819:agonists / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D048588:Benzoxazines; D063385:Cannabinoid Receptor Modulators; D002186:Cannabinoids; D063388:Endocannabinoids; D009025:Morpholines; D009281:Naphthalenes; D043884:Receptor, Cannabinoid, CB1; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; C070417:(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone