Lack of association between angiotensin I-converting enzyme insertion/deletion polymorphism and psoriasis or psoriatic arthritis in Spain.
Data on the potential influence of the angiotensin-converting enzyme (ACE) insertion/ deletion (I/D) genotype on psoriasis are contradictory. Our aim was to investigate the relationship between the ACE gene I/D polymorphism and psoriasis/psoriatic arthritis. To investigate this, a genetic association study was conducted among 268 unrelated patients with psoriasis and 272 controls. The distribution of DD, ID, and II genotypes did not significantly differ between psoriatic patients and controls (DD: 39.6% vs. 34.2%; ID: 46.3% vs. 53.3%; II: 14.1% vs. 12.5%). In conclusion, the ACE polymorphism is not likely to be associated with either psoriasis or psoriatic arthritis in this study.
Coto-Segura
Pablo
P
Dermatología II department, Hospital Universitario Central de Asturias, Oviedo, Spain.
Alvarez
Victoria
V
Soto-Sánchez
Javier
J
Morales
Blanca
B
Coto
Eliecer
E
Santos-Juanes
Jorge
J
D000328:Adult; D015535:Arthritis, Psoriatic / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000201:enzymology / Q000235:genetics*; D017384:Sequence Deletion; D013030:Spain; D044465:White People / Q000235:genetics
D007703:Peptidyl-Dipeptidase A