title: Postoperative pain control after cesarean section: can diclofenac sodium be used instead of meperidine?
abstract: OBJECTIVE
  To determine the advantages and disadvantages of the use of diclofenac sodium instead of meperidine for postcesarean section pain control.
  
  
  METHODS
  A total of 130 patients who had undergone cesarean section at the Department of Obstetrics and Gynecology of Gazi University Hospital were prospectively randomised to receive one of two postoperative pain control regimens. The first group of patients received intramuscular diclofenac sodium at a dose of 2 x 75 mg and additional breakthrough meperidine was given intramuscularly at 50 mg dosages each time, if necessary. Patients in the second group received only 6 x 50 mg meperidine.
  
  
  RESULTS
  Twenty-seven of the 65 patients in the diclofenac group complained of unrelieved pain within the subsequent 24 h postoperatively. Patients receiving diclofenac alone or a combination of diclofenac + meperidine were less sedated and the time to the first passing of flatus was shorter than that in the patients treated with only meperidine.
  
  
  CONCLUSIONS
  Diclofenac alone was safe and effective for the majority of the patients and it decreased the opioid requirements in the remaining patients.
authors.affiliation: Department of Obstetrics and Gynecology, Gazi University School of Medicine, Ankara, Turkey.
authors.forename: Nuray
authors.initials: N
authors.lastname: Bozkurt
authors.forename: Mertihan
authors.initials: M
authors.lastname: Kurdoglu
authors.forename: Zehra
authors.initials: Z
authors.lastname: Kurdoglu
authors.forename: Fatma
authors.initials: F
authors.lastname: Kutlusoy
authors.forename: Kutay
authors.initials: K
authors.lastname: Biberoglu
mesh_terms: D000328:Adult; D016362:Analgesia, Obstetrical / Q000009:adverse effects / Q000379:methods*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D002585:Cesarean Section / Q000009:adverse effects / Q000534:rehabilitation*; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008614:Meperidine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011247:Pregnancy; D016037:Single-Blind Method; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D008614:Meperidine