title: Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways.
abstract: The antidiabetic therapeutic effect of Ecklonia cava, a brown alga, was investigated using streptozotocin-induced type 1 diabetes mellitus rats and C2C12 myoblasts. The methanol extract of E. cava (ECM), having a strong radical scavenging activity, significantly reduced plasma glucose level and increased insulin concentration in type 1 diabetes mellitus rats. Moreover, the elevation of plasma ALT in diabetic rats was dramatically restored near to normal range by the treatment of ECM, whereas AST level was not meaningfully altered in any group throughout the experiment. The characteristic indications of diabetes, such as polyphagia and polydipsia, were greatly improved by ECM treatment as well. The mechanism of action of ECM appears to be, at least partially, mediated by the activation of both AMP-activated protein kinase/ACC and PI-3 kinase/Akt signal pathways. Taken together, the present results suggest that E. cava has both in vivo and in vitro antidiabetic effects.
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, South Korea.
authors.forename: Changkeun
authors.initials: C
authors.lastname: Kang
authors.forename: Yeung Bae
authors.initials: YB
authors.lastname: Jin
authors.forename: Hyunkyoung
authors.initials: H
authors.lastname: Lee
authors.forename: Mijin
authors.initials: M
authors.lastname: Cha
authors.forename: Eun-tae
authors.initials: ET
authors.lastname: Sohn
authors.forename: Jonghyun
authors.initials: J
authors.lastname: Moon
authors.forename: Cholwoo
authors.initials: C
authors.lastname: Park
authors.forename: Soohee
authors.initials: S
authors.lastname: Chun
authors.forename: Eun-Sun
authors.initials: ES
authors.lastname: Jung
authors.forename: Jeong-Sook
authors.initials: JS
authors.lastname: Hong
authors.forename: Soon Bok
authors.initials: SB
authors.lastname: Kim
authors.forename: Jong-Shu
authors.initials: JS
authors.lastname: Kim
authors.forename: Euikyung
authors.initials: E
authors.lastname: Kim
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000187:drug effects* / Q000378:metabolism; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D005419:Flavonoids / Q000032:analysis; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D000432:Methanol / Q000737:chemistry; D051379:Mice; D018485:Muscle Fibers, Skeletal / Q000166:cytology / Q000187:drug effects; D032448:Myoblasts, Skeletal / Q000166:cytology / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D000459:Phaeophyceae / Q000737:chemistry*; D010636:Phenols / Q000032:analysis; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D059808:Polyphenols; D051057:Proto-Oncogene Proteins c-akt / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D005419:Flavonoids; D016166:Free Radical Scavengers; D007004:Hypoglycemic Agents; D007328:Insulin; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D051057:Proto-Oncogene Proteins c-akt; D055372:AMP-Activated Protein Kinases; D000432:Methanol