Association between Helicobacter pylori seropositivity and digestive tract cancers.
OBJECTIVE
To explore the role of Helicobacter pylori (H pylori) infection on the risk of digestive tract cancers.


METHODS
In total, 199 oral squamous-cell carcinoma (SCC), 317 esophageal SCC, 196 gastric cardia and non-cardia adenocarcinoma and 240 colon adenocarcinoma patients were recruited for serum tests of H pylori infection. Two hospital- and one community-based control groups were used for the comparisons. H pylori seropositivity was determined by an enzyme linked immunosorbent assay method against H pylori IgG.


RESULTS
Presence of H pylori infection was significantly inversely associated with esophageal SCC [adjusted odds ratio (AOR): 0.315-0.472, all P-value < 0.05] but positively associated with gastric adenocarcinoma (both cardia and non-cardia) (AOR: 1.636-3.060, all P-value < 0.05) in comparison to the three control groups. Similar results were not found in cancers of the oral cavity and colon.


CONCLUSIONS
Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma.
Wu
I-Chen
IC
Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, China.
Wu
Deng-Chyang
DC
Yu
Fang-Jung
FJ
Wang
Jaw-Yuan
JY
Kuo
Chao-Hung
CH
Yang
Sheau-Fang
SF
Wang
Chao-Ling
CL
Wu
Ming-Tsang
MT
D000230:Adenocarcinoma / Q000150:complications / Q000382:microbiology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000382:microbiology*; D002299:Cardia / Q000382:microbiology*; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000150:complications / Q000382:microbiology*; D005260:Female; D016481:Helicobacter Infections / Q000097:blood* / Q000150:complications*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D013274:Stomach Neoplasms / Q000150:complications / Q000382:microbiology*
D000942:Antigens, Bacterial