title: En bloc spondylectomy for treatment of tumor-induced osteomalacia.
abstract: En bloc spondylectomy represents a radical resection of a spinal segment most often reserved for patients presenting with a primary extradural spine tumor or a solitary metastasis in the setting of an indolent, well-controlled systemic malignancy. The authors report a case in which en bloc spondylectomy was conducted to control a metabolically active spine tumor. A 56-year-old woman, who suffered from severe tumor-induced osteomalacia, was found to have a fibroblast growth factor-23-secreting phosphaturic mesenchymal tumor in the T-8 vertebral body. En bloc resection was conducted, leading to resolution of her tumor-induced osteomalacia. This case suggests that radical spondylectomy may be beneficial in the management of metabolically or endocrinologically active tumors of the spine.
authors.affiliation: Department of Neurosurgery, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Sciubba
authors.forename: Rory J
authors.initials: RJ
authors.lastname: Petteys
authors.forename: Sophia F
authors.initials: SF
authors.lastname: Shakur
authors.forename: Ziya L
authors.initials: ZL
authors.lastname: Gokaslan
authors.forename: Edward F
authors.initials: EF
authors.lastname: McCarthy
authors.forename: Michael T
authors.initials: MT
authors.lastname: Collins
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: McGirt
authors.forename: Patrick C
authors.initials: PC
authors.lastname: Hsieh
authors.forename: Clarke S
authors.initials: CS
authors.lastname: Nelson
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Wolinsky
mesh_terms: D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010018:Osteomalacia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery*; D019651:Plastic Surgery Procedures; D013123:Spinal Fusion; D013125:Spinal Neoplasms / Q000150:complications* / Q000378:metabolism / Q000601:surgery*; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23