title: Flavones and phenylpropanoids from a sedative extract of Lantana trifolia L.
abstract: The flavone glycosides, named scutellarein-7-O-beta-D-apiofuranoside and apigenin-7-O-beta-D-apiofuranosyl-(1-->2)-beta-D-apiofuranoside, and the flavone celtidifoline (5,6,4',5'-tetrahydroxy-7,3'-dimethoxyflavone), along with other 11 known compounds, were isolated from leaves of the ethyl acetate extract of Lantana trifolia L. using step gradient High Speed Countercurrent Chromatography (HSCCC) and High Performance Liquid Chromatography (HPLC), respectively. Their structures were elucidated by spectroscopic methods, including 2D NMR and mass spectrometry (ESI-MS) techniques. The ethanolic and ethyl acetate extracts produced an intense sedative effect in mice, one hour after oral administration of 1 mg/kg. This effect was neither due to a benzodiazepine-like effect of the three flavone derivatives neither of the phenylpropanoids, betonyoside F and verbascoside, that were tested for their affinity for the [3H] flunitrazepam binding sites.
authors.affiliation: Universidade Federal do Rio de Janeiro, Programa de Biotecnologia Vegetal, CCS, Bl. K, Rio de Janeiro, RJ, Brazil.
authors.forename: Lisieux de Santana
authors.initials: Lde S
authors.lastname: Julião
authors.forename: Suzana Guimarães
authors.initials: SG
authors.lastname: Leitão
authors.forename: Cinzia
authors.initials: C
authors.lastname: Lotti
authors.forename: Anna Lisa
authors.initials: AL
authors.lastname: Picinelli
authors.forename: Luca
authors.initials: L
authors.lastname: Rastrelli
authors.forename: Patricia D
authors.initials: PD
authors.lastname: Fernandes
authors.forename: François
authors.initials: F
authors.lastname: Noël
authors.forename: Jean-Pierre Barros
authors.initials: JP
authors.lastname: Thibaut
authors.forename: Gilda Guimarães
authors.initials: GG
authors.lastname: Leitão
mesh_terms: D000818:Animals; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006993:Hypnotics and Sedatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032410:Lantana / Q000737:chemistry*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D020005:Propanols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D047309:Flavones; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D020005:Propanols