title: Chronic hepatitis with eosinophilic infiltration associated with asthma.
abstract: A 49-year-old asthmatic woman with a history of drug allergy to aspirin and penicillin presented to the hospital with fever, dark urine, general exanthema and fatigue. Physical examination revealed jaundice. She had been taking four different over-the-counter drugs. Laboratory examination showed eosinophilia, elevated Ig E, hyperbilirubinemia and elevated liver function tests. HBs Ag, anti-HCV Ab and Ig M anti-HA were negative. She was initially diagnosed with drug-induced hepatitis and was treated with steroids. However, liver dysfunction with eosinophilia relapsed after discontinuing steroids. Liver biopsy revealed eosinophilic infiltration. Steroids were discontinued after the start of 6-mercaptopurine.
authors.affiliation: Gastroenterology Center, St Luke's International Hospital, Tokyo. f_omata@mac.com
authors.forename: Fumio
authors.initials: F
authors.lastname: Omata
authors.forename: Minoru
authors.initials: M
authors.lastname: Shibata
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakano
authors.forename: Joshua L
authors.initials: JL
authors.lastname: Jacobs
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Tokuda
authors.forename: Tokuda
authors.initials: T
authors.lastname: Yasuharu
authors.forename: Katsuhide
authors.initials: K
authors.lastname: Fukutake
authors.forename: Osamu
authors.initials: O
authors.lastname: Takahashi
authors.forename: Tsuguya
authors.initials: T
authors.lastname: Fukui
mesh_terms: D001249:Asthma / Q000150:complications*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000150:complications; D004802:Eosinophilia / Q000150:complications*; D005260:Female; D019693:Hepatitis, Autoimmune / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology*; D008111:Liver Function Tests; D008875:Middle Aged