title: Serum N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) and homocysteine levels in type 2 diabetic patients with asymptomatic left ventricular diastolic dysfunction.
abstract: OBJECTIVE
  : The aim of this study was to determine serum NT-proBNP and plasma Hcy levels and to explore the relationship between serum NT-proBNP and plasma Hcy levels in type 2 diabetic patients with and without asymptomatic LVDD.
  
  
  METHODS
  : NT-proBNP and Hcy levels were measured 31 patients with type 2 diabetes mellitus. According to echocardiographic data, diabetic patients were divided into two groups: normal LV function or LV diastolic dysfunction.
  
  
  RESULTS
  : Serum NT-proBNP levels in diabetic patients with LVDD were significantly higher than in diabetic patients with normal LV function and controls. The area under the receiver-operating characteristic (ROC) curve for NT-proBNP to separate normal vs. diastolic dysfunction was 0.96 in type 2 diabetic patients. Plasma Hcy levels were significantly higher in both diabetic groups than in controls. Positive correlation was noted between NT-proBNP and Hcy levels in diabetic patients with LVDD (r=0.881, p=0.0001).
  
  
  CONCLUSIONS
  : The correlation between elevated NT-proBNP and Hcy levels in diabetic patients with LVDD suggest an association between homocysteinemia and increased NT-proBNP secretion. Our data indicate that NT-proBNP may be a simple screening tool to select diabetic patients with LVDD requiring further examination with echocardiography.
authors.affiliation: Department of Molecular Medicine, Institute of Experimental Medical Research, Istanbul University, Istanbul, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Görmüş
authors.forename: D
authors.initials: D
authors.lastname: Ozmen
authors.forename: B
authors.initials: B
authors.lastname: Ozmen
authors.forename: Z
authors.initials: Z
authors.lastname: Parildar
authors.forename: O
authors.initials: O
authors.lastname: Ozdoğan
authors.forename: I
authors.initials: I
authors.lastname: Mutaf
authors.forename: O
authors.initials: O
authors.lastname: Bayindir
mesh_terms: D001794:Blood Pressure; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003925:Diabetic Angiopathies / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D003971:Diastole; D004452:Echocardiography; D017548:Echocardiography, Transesophageal; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D006710:Homocysteine; D020097:Natriuretic Peptide, Brain; D003404:Creatinine