Association of interleukin-8 gene polymorphism with cachexia from patients with gastric cancer.
Interleukin (IL)-8 has been implicated in a wide range of diseases. The polymorphism of IL-8 gene, which may affect the production level of the cytokine, may be associated with cancer cachexia. To test this hypothesis, we investigated the potential influence of the polymorphisms of the IL-8 gene, -251 A/T and +781 C/T, on susceptibility to cachexia from patients with gastric cancer in a Chinese population, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). A significantly increased frequency of +781 T allele was noted in patients with cachexia (OR = 1.765, 95% CI: 1.192-2.615, P = 0.004). The +781 TT genotypes were observed to be associated with a significantly increased risk of cachexia (OR = 2.156, 95% CI: 1.056-4.400, P = 0.033), and the difference was enhanced beyond the level of statistical significance when logistic regression was applied (OR = 3.500, 95% CI: 1.406-8.710, P = 0.007). Haplotype analysis revealed that A(251)T(781) haplotype (defined by SNPs at positions -251 and +781) was associated with a significantly increased risk of cachexia as compared with the T(251)C(781) haplotype (OR = 1.69; 95% CI: 1.08-2.62; P = 0.022). These results suggest that the genetic polymorphisms of proinflammatory cytokine IL-8 may contribute to the pathogenesis of cachexia in gastric cancer patients.
Bo
Song
S
Department of General Surgery, Affiliated Hospital of Qingdao University Medical College, People's Republic of China.
Dianliang
Zhang
Z
Hongmei
Zheng
Z
Xinxiang
Wang
W
Yanbing
Zhou
Z
Xiaobo
Liu
L
D000230:Adenocarcinoma / Q000097:blood / Q000150:complications / Q000235:genetics* / Q000276:immunology; D000328:Adult; D000368:Aged; D002100:Cachexia / Q000097:blood / Q000150:complications / Q000235:genetics* / Q000276:immunology; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016209:Interleukin-8 / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000097:blood / Q000150:complications / Q000235:genetics* / Q000276:immunology
D016209:Interleukin-8