Pathological features of bone marrow transplantation-related toxicity in a mouse.
In this case report, we present a mock-transduced bone marrow (BM) transplantation in a mouse, which was found moribund and autopsied to evaluate pathogenesis. Macroscopically, red discoloration of systemic organs was observed. Hematological values revealed a decrease in white blood cells, red blood cells, hematocrit, hemoglobin, and platelets, but an increase in reticulocytes. In BM cytology, hematopoietic cell lines were severely depleted. Histopathologically, hemorrhage in the cerebellar parenchyma, hemosiderin deposition and hemorrhage in the heart, necrosis and telangiectasia in liver, pulmonary parenchymal cysts, spermatogenic germ cells necrosis, atrophy and hemorrhage in testis, oligospermia and hemorrhage in the epididymis, and atrophy of BM, thymus and spleen were observed. In conclusion, autoimmune-like complications such as hematological value change, BM dysplasia and systemic hemorrhage appear to be the lethal cause of the mouse transplanted with mock-transduced BM.
Kim
Yong Hoon
YH
Institute of Veterinary Science, Chungnam National University, Daejeon 305-764, Korea.
Ha
Chang Su
CS
Lee
Hyun Sook
HS
Lim
Sun Hwa
SH
Moon
Kyoung Sik
KS
Chung
Moon Koo
MK
Son
Hwa Young
HY
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002531:Cerebellum / Q000473:pathology; D006470:Hemorrhage / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009206:Myocardium / Q000473:pathology; D013737:Testis / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology