Complexins living up to their name--new light on their role in exocytosis.
Ca(2+)-dependent exocytosis of synaptic vesicles is mediated by the SNARE proteins synaptobrevin/VAMP, SNAP-25, and syntaxin. SNARE function is controlled by conserved regulatory proteins, including the complexins. In a study by Xue et al. in this issue of Neuron, contradictory data from Drosophila and mouse complexin mutants have been resolved, revealing a complex pattern of facilitatory and inhibitory domains.
Stein
Alexander
A
Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany.
Jahn
Reinhard
R
D033942:Adaptor Proteins, Vesicular Transport / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D004330:Drosophila; D005089:Exocytosis / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008959:Models, Neurological; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000502:physiology; D050600:SNARE Proteins / Q000378:metabolism; D013045:Species Specificity; D013569:Synapses / Q000502:physiology
D033942:Adaptor Proteins, Vesicular Transport; D009419:Nerve Tissue Proteins; D050600:SNARE Proteins