title: Anti-diabetic effect of camel milk in alloxan-induced diabetic dogs: a dose-response experiment.
abstract: This study was conducted to evaluate the effect of camel milk in alloxan-induced diabetic dogs and to follow this effect at three doses of milk. Firstly, three groups of dogs were used: two groups composed each of four diabetic dogs and receiving raw camel milk (treatment 1) or cow milk (treatment 2), and four healthy dogs getting raw camel milk (treatment 3) were used as control. Each animal was treated with 500 ml of milk daily. Secondly, we compared the effects of three amounts of camel milk: 100 ml, 250 ml and 500 ml to treat the diabetic dogs. After week 3, the dogs treated with camel milk showed a statistically significant decrease in blood glucose (from 10.88 +/- 0.55 to 6.22 +/- 0.5 mmol/l) and total protein concentrations (from 78.16 +/- 2.61 g/l to 63.63 +/- 4.43 g/l). For cholesterol levels, there was a decrease from week 2 (from 6.17 +/- 0.5 mmol/l to 4.79 +/- 0.5 mmol/l). There were no significant difference in blood glucose, cholesterol or total protein concentrations in dogs drinking 250 and 500 ml of camel milk. The dogs treated with 100 ml of camel milk did not show any significant decrease in blood glucose levels, and cholesterol and total protein concentrations. The investigation was not limited to the improvement in glycemic balance, lipids and proteins control in diabetic dogs getting camel milk, but we also noted a stability of this state after the dogs stopped to drink milk. This effect depended on the quantity of camel milk used to treat diabetic dogs.
authors.affiliation: Arid Land Institute, Livestock and Wildlife Laboratory, Medenine, Tunisia.
authors.forename: A
authors.initials: A
authors.lastname: Sboui
authors.forename: T
authors.initials: T
authors.lastname: Khorchani
authors.forename: M
authors.initials: M
authors.lastname: Djegham
authors.forename: A
authors.initials: A
authors.lastname: Agrebi
authors.forename: H
authors.initials: H
authors.lastname: Elhatmi
authors.forename: O
authors.initials: O
authors.lastname: Belhadj
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001798:Blood Proteins / Q000032:analysis; D002162:Camelus; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000178:diet therapy*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D008892:Milk; D011897:Random Allocation; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D002784:Cholesterol