title: Absolute electrical impedance tomography (aEIT) guided ventilation therapy in critical care patients: simulations and future trends.
abstract: Thoracic electrical impedance tomography (EIT) is a noninvasive, radiation-free monitoring technique whose aim is to reconstruct a cross-sectional image of the internal spatial distribution of conductivity from electrical measurements made by injecting small alternating currents via an electrode array placed on the surface of the thorax. The purpose of this paper is to discuss the fundamentals of EIT and demonstrate the principles of mechanical ventilation, lung recruitment, and EIT imaging on a comprehensive physiological model, which combines a model of respiratory mechanics, a model of the human lung absolute resistivity as a function of air content, and a 2-D finite-element mesh of the thorax to simulate EIT image reconstruction during mechanical ventilation. The overall model gives a good understanding of respiratory physiology and EIT monitoring techniques in mechanically ventilated patients. The model proposed here was able to reproduce consistent images of ventilation distribution in simulated acutely injured and collapsed lung conditions. A new advisory system architecture integrating a previously developed data-driven physiological model for continuous and noninvasive predictions of blood gas parameters with the regional lung function data/information generated from absolute EIT (aEIT) is proposed for monitoring and ventilator therapy management of critical care patients.
authors.affiliation: Department of Automatic Control and Systems Engineering, University of Sheffield, Sheffield, UK. m.denai@shef.ac.uk
authors.forename: Mouloud A
authors.initials: MA
authors.lastname: Denaï
authors.forename: Mahdi
authors.initials: M
authors.lastname: Mahfouf
authors.forename: Suzani
authors.initials: S
authors.lastname: Mohamad-Samuri
authors.forename: George
authors.initials: G
authors.lastname: Panoutsos
authors.forename: Brian H
authors.initials: BH
authors.lastname: Brown
authors.forename: Gary H
authors.initials: GH
authors.lastname: Mills
mesh_terms: D003198:Computer Simulation; D003422:Critical Care; D017097:Electric Impedance; D020342:Finite Element Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000033:anatomy & histology / Q000502:physiology; D008954:Models, Biological; D012121:Respiration, Artificial / Q000379:methods*; D012815:Signal Processing, Computer-Assisted; D013909:Thorax / Q000033:anatomy & histology / Q000502:physiology; D014054:Tomography / Q000379:methods*