Inverse association between serum 25(OH) vitamin D levels  and non-melanoma skin cancer in elderly men.
To determine the relationship between 25(OH) vitamin D levels and non-melanoma skin cancer (NMSC), we performed a nested case-control study in ambulatory, elderly men enrolled in the Osteoporotic Fractures in Men (MrOS) Study. Health habit and medical history, including self-reported history of NMSC were recorded and 25(OH)D levels were measured on serum collected at baseline from a random sample of Caucasian MrOS subjects. Mean age (73 +/- 5), BMI, daily vitamin D and calcium intake were similar in the men with (n = 178) and without NMSC (n = 930), but higher levels of 25(OH)D were associated with a decreased risk of having a history of NMSC (P(trend) = 0.04). Men in the highest quintile of 25(OH)D (>30 ng/mL) had 47% lower odds of NMSC (95% CI: 0.30-0.93, p = 0.026) compared to those in the lowest quintile. Our results suggest that a diagnosis of NMSC is not a surrogate for adequate 25(OH)D levels or increased UV exposure, and high 25(OH)D levels may be associated with a reduced risk of NMSC.
Tang
Jean Y
JY
Children's Hospital of Oakland Research Institute, USA. tangy@stanford.edu
Parimi
Neeta
N
Wu
Angela
A
Boscardin
W John
WJ
Shikany
James M
JM
Chren
Mary-Margaret
MM
Cummings
Steven R
SR
Epstein
Ervin H
EH
Bauer
Douglas C
DC
D000368:Aged; D002136:Calcium, Dietary / Q000008:administration & dosage / Q000097:blood; D016022:Case-Control Studies; D019587:Dietary Supplements; D006801:Humans; D008019:Life Style; D008297:Male; D012307:Risk Factors; D012878:Skin Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000208:ethnology* / Q000517:prevention & control; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood; D044465:White People
D002136:Calcium, Dietary; D014807:Vitamin D; C104450:25-hydroxyvitamin D