title: Renal and hepatic function improve in advanced heart failure patients during continuous-flow support with the HeartMate II left ventricular assist device.
abstract: BACKGROUND
  The effects of continuous blood flow and reduced pulsatility on major organ function have not been studied in detail.
  
  
  RESULTS
  We evaluated renal (creatinine and blood urea nitrogen) and hepatic (aspartate transaminase, alanine transaminase, and total bilirubin) function in 309 (235 male, 74 female) advanced heart failure patients who had been supported with the HeartMate II continuous-flow left ventricular assist device for bridge to transplantation. To determine whether patients with impaired renal and hepatic function improve over time with continuous-flow left ventricular assist device support or whether there are any detrimental effects in patients with normal organ function, we divided patients into those with above-normal and normal laboratory values before implantation and measured blood chemistry over time during left ventricular assist device support. There were significant improvements over 6 months in all parameters in the above-normal groups, with values in the normal groups remaining in the normal range over time. Mean blood urea nitrogen and serum creatinine in the above-normal groups decreased significantly from 37+/-14 to 23+/-10 mg/dL (P<0.0001) and from 1.8+/-0.4 to 1.4+/-0.8 mg/dL (P<0.01), respectively. There were decreases in aspartate transaminase and alanine transaminase in the above-normal groups from 121+/-206 and 171+/-348 to 36+/-19 and 31+/-22 IU (P<0.001), respectively. Total bilirubin for the above-normal group was 2.1+/-0.9 mg/dL at baseline; after an acute increase at week 1, it decreased to 0.9+/-0.5 mg/dL by 6 months (P<0.0001). Both renal and liver values from patients in the normal groups remained normal during support with the left ventricular assist device.
  
  
  CONCLUSIONS
  The HeartMate II continuous-flow left ventricular assist device improves renal and hepatic function in advanced heart failure patients who are being bridged to transplantation, without evidence of detrimental effects from reduced pulsatility over a 6-month time period.
authors.affiliation: Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA. srusse14@jhmi.edu
authors.forename: Stuart D
authors.initials: SD
authors.lastname: Russell
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Rogers
authors.forename: Carmelo A
authors.initials: CA
authors.lastname: Milano
authors.forename: David B
authors.initials: DB
authors.lastname: Dyke
authors.forename: Francis D
authors.initials: FD
authors.lastname: Pagani
authors.forename: Juan M
authors.initials: JM
authors.lastname: Aranda
authors.forename: Charles T
authors.initials: CT
authors.lastname: Klodell
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Boyle
authors.forename: Ranjit
authors.initials: R
authors.lastname: John
authors.forename: Leway
authors.initials: L
authors.lastname: Chen
authors.forename: H Todd
authors.initials: HT
authors.lastname: Massey
authors.forename: David J
authors.initials: DJ
authors.lastname: Farrar
authors.forename: John V
authors.initials: JV
authors.lastname: Conte
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006333:Heart Failure / Q000503:physiopathology* / Q000601:surgery*; D006353:Heart-Assist Devices; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008099:Liver / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology*; D055815:Young Adult