Understanding microRNAs in neurodegeneration.
Interest in the functions of microRNAs (miRNAs) in the nervous system has recently expanded to include their roles in neurodegeneration. Investigations have begun to reveal the influence of miRNAs on both neuronal survival and the accumulation of toxic proteins that are associated with neurodegeneration, and are providing clues as to how these toxic proteins can influence miRNA expression.
Eacker
Stephen M
SM
Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. tdawson@jhmi.edu
Dawson
Ted M
TM
Dawson
Valina L
VL
D000818:Animals; D001923:Brain Chemistry / Q000235:genetics / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000502:physiology; D009410:Nerve Degeneration / Q000235:genetics* / Q000503:physiopathology; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000502:physiology
D035683:MicroRNAs; D009419:Nerve Tissue Proteins