Spontaneously formed unilamellar vesicles.
Mixtures of long- and short-chain phospholipids can spontaneously form uniform unilamellar vesicles (ULVs) with diameters 50 nm (polydispersities of <0.3) or less. The morphology of these ULVs has mainly been characterized using small angle neutron scattering (SANS), a technique highly suited for the study of hydrogenous materials. Once formed, these ULVs have turned out to be highly stable and show great promise as imaging and therapeutic carriers.
Nieh
Mu-Ping
MP
Canadian Neutron Beam Centre, Steacie Institute for Molecular Sciences, Chalk River Laboratories, National Research Council Canada, Chalk River, Ontario, Canada.
Kucerka
Norbert
N
Katsaras
John
J
D008055:Lipids / Q000737:chemistry; D008081:Liposomes; D008823:Micelles
D008055:Lipids; D008081:Liposomes; D008823:Micelles