title: Differences in oxidative stress markers based on the aetiology of heart failure: comparison of oxidative stress in patients with and without coronary artery disease.
abstract: Various oxidative stress markers have been measured to evaluate the status of heart failure (HF). However, the relationships between these markers and the aetiology of HF have not been fully investigated. This study compared 8-hydroxy-2'-deoxyguanosine (8-OHdG) and biopyrrins levels in patients with ischemic and non-ischemic HF. Study subjects were divided into a coronary artery disease (CAD) group (n=70), a non-CAD group (n=61) and a control group (n=33). In the CAD group, 8-OHdG and biopyrrins levels increased with the severity of the New York Heart Association (NYHA) functional class and log BNP levels correlated with 8-OHdG and biopyrrins levels. However, non-CAD patients with NYHA class III/IV had significantly lower 8-OHdG levels than CAD patients with NYHA class III/IV and the levels did not correlate with log BNP levels. In the CAD group, 8-OHdG levels reflected the severity of atherosclerosis. These results indicate that the properties of oxidative stress markers should be carefully taken into consideration for the assessment of HF status.
authors.affiliation: Department of Community Medicine, Kumamoto University Hospital, Kumamoto City, Japan. ynagayos@kumamoto-u.ac.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nagayoshi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kawano
authors.forename: Jun
authors.initials: J
authors.lastname: Hokamaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Uemura
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Soejima
authors.forename: Koichi
authors.initials: K
authors.lastname: Kaikita
authors.forename: Seigo
authors.initials: S
authors.lastname: Sugiyama
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Yamabe
authors.forename: Izuru
authors.initials: I
authors.lastname: Shioji
authors.forename: Shinya
authors.initials: S
authors.lastname: Sasaki
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kuroda
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000368:Aged; D001663:Bilirubin / Q000652:urine; D015415:Biomarkers / Q000652:urine; D003324:Coronary Artery Disease / Q000150:complications* / Q000652:urine*; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006333:Heart Failure / Q000209:etiology* / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: D015415:Biomarkers; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; D001663:Bilirubin