title: Caveolin-1 promotes autoregulatory, Akt-mediated induction of cancer-promoting growth factors in prostate cancer cells.
abstract: Caveolin-1 (cav-1) and the cancer-promoting growth factors vascular endothelial growth factor (VEGF), transforming growth factor beta1 (TGF-beta1), and fibroblast growth factor 2 (FGF2) are often found to be upregulated in advanced prostate cancer and other malignancies. However, the relationship between cav-1 overexpression and growth factor upregulation remains unclear. This report presents, to our knowledge, the first evidence that in prostate cancer cells, a positive autoregulatory feedback loop is established in which VEGF, TGF-beta1, and FGF2 upregulate cav-1, and cav-1 expression, in turn, leads to increased levels of VEGF, TGF-beta1, and FGF2 mRNA and protein, resulting in enhanced invasive activities of prostate cancer cells, i.e., migration and motility. Our results further show that cav-1-enhanced mRNA stability is a major mechanism underlying the upregulation of these cancer-promoting growth factors, and that PI3-K-Akt signaling is required for forming this positive autoregulatory feedback loop.
authors.affiliation: Department of Genitourinary Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030-4009, USA.
authors.forename: Likun
authors.initials: L
authors.lastname: Li
authors.forename: Chengzhen
authors.initials: C
authors.lastname: Ren
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.forename: Alexei A
authors.initials: AA
authors.lastname: Goltsov
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Tabata
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Thompson
mesh_terms: D000818:Animals; D015153:Blotting, Western; D051242:Caveolin 1 / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology; D018450:Disease Progression; D004789:Enzyme Activation; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D051379:Mice; D051058:Oncogene Protein v-akt / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D020871:RNA Stability; D015398:Signal Transduction; D053773:Transforming Growth Factor beta1 / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism
chemical_list: D051242:Caveolin 1; D036341:Intercellular Signaling Peptides and Proteins; D053773:Transforming Growth Factor beta1; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; D051058:Oncogene Protein v-akt