A new prediction model of postoperative complications after major hepatectomy for hepatocellular carcinoma.
OBJECTIVE
Serum hyaluronic acid (HA) concentrations reflect the degree of hepatic dysfunction and may have potential for predicting postoperative complications in a major hepatectomy for hepatocellular carcinoma (HCC).


METHODS
Serum HA concentrations and other conventional liver function tests were measured prior to major hepatectomies in 52 patients. Independent predictors for postoperative complications were analyzed and the discriminant equation was established and validated.


RESULTS
Postoperative complications occurred in 17 patients. Serum HA concentrations and the estimated remnant liver volume ratio (remnant Vol%) were recognized as independent predictors for postoperative complications (OR 1.03, 0.85; CI 95% 1.01-1.06, 0.76-0.95; p = 0.006, 0.006; respectively) and produced the discriminant equation: logit = 4.15 + 0.03 x (HA) -0.16 x (remnant Vol%). The value of the area under the curve of a receiver operating characteristic analysis was 0.92. If the cut-off of the logit value was set to 0, then the predictive accuracy was 0.88. The validation accuracy performed by a leave-one-out cross-validation method was 0.83.


CONCLUSIONS
The constructed discriminant equation model consisting of the preoperative serum HA concentrations and estimated remnant Vol% could be useful for predicting postoperative complications in a major hepatectomy for HCC.
Ueno
Masaki
M
Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan.
Uchiyama
Kazuhisa
K
Ozawa
Satoru
S
Hayami
Shinya
S
Kiriyama
Shigehisa
S
Yamaue
Hiroki
H
D000368:Aged; D000465:Algorithms; D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000601:surgery; D016002:Discriminant Analysis; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000097:blood* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011183:Postoperative Complications / Q000175:diagnosis* / Q000401:mortality; D012372:ROC Curve
D015415:Biomarkers; D006820:Hyaluronic Acid