title: COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.
abstract: It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.
authors.affiliation: Molecular and Population Genetics, Nuffield Department of Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
authors.forename: I P M
authors.initials: IP
authors.lastname: Tomlinson
authors.forename: M
authors.initials: M
authors.lastname: Dunlop
authors.forename: H
authors.initials: H
authors.lastname: Campbell
authors.forename: B
authors.initials: B
authors.lastname: Zanke
authors.forename: S
authors.initials: S
authors.lastname: Gallinger
authors.forename: T
authors.initials: T
authors.lastname: Hudson
authors.forename: T
authors.initials: T
authors.lastname: Koessler
authors.forename: P D
authors.initials: PD
authors.lastname: Pharoah
authors.forename: I
authors.initials: I
authors.lastname: Niittymäki
authors.forename: I
authors.initials: I
authors.lastname: Niittymäkix
authors.forename: S
authors.initials: S
authors.lastname: Tuupanen
authors.forename: S
authors.initials: S
authors.lastname: Tuupanenx
authors.forename: L A
authors.initials: LA
authors.lastname: Aaltonen
authors.forename: K
authors.initials: K
authors.lastname: Hemminki
authors.forename: A
authors.initials: A
authors.lastname: Lindblom
authors.forename: A
authors.initials: A
authors.lastname: Försti
authors.forename: O
authors.initials: O
authors.lastname: Sieber
authors.forename: L
authors.initials: L
authors.lastname: Lipton
authors.forename: T
authors.initials: T
authors.lastname: van Wezel
authors.forename: H
authors.initials: H
authors.lastname: Morreau
authors.forename: J T
authors.initials: JT
authors.lastname: Wijnen
authors.forename: P
authors.initials: P
authors.lastname: Devilee
authors.forename: K
authors.initials: K
authors.lastname: Matsuda
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Castellví-Bel
authors.forename: C
authors.initials: C
authors.lastname: Ruiz-Ponte
authors.forename: A
authors.initials: A
authors.lastname: Castells
authors.forename: A
authors.initials: A
authors.lastname: Carracedo
authors.forename: J W C
authors.initials: JW
authors.lastname: Ho
authors.forename: P
authors.initials: P
authors.lastname: Sham
authors.forename: R M W
authors.initials: RM
authors.lastname: Hofstra
authors.forename: P
authors.initials: P
authors.lastname: Vodicka
authors.forename: H
authors.initials: H
authors.lastname: Brenner
authors.forename: J
authors.initials: J
authors.lastname: Hampe
authors.forename: C
authors.initials: C
authors.lastname: Schafmayer
authors.forename: J
authors.initials: J
authors.lastname: Tepel
authors.forename: S
authors.initials: S
authors.lastname: Schreiber
authors.forename: H
authors.initials: H
authors.lastname: Völzke
authors.forename: M M
authors.initials: MM
authors.lastname: Lerch
authors.forename: C A
authors.initials: CA
authors.lastname: Schmidt
authors.forename: S
authors.initials: S
authors.lastname: Buch
authors.forename: V
authors.initials: V
authors.lastname: Moreno
authors.forename: C M
authors.initials: CM
authors.lastname: Villanueva
authors.forename: P
authors.initials: P
authors.lastname: Peterlongo
authors.forename: P
authors.initials: P
authors.lastname: Radice
authors.forename: M M
authors.initials: MM
authors.lastname: Echeverry
authors.forename: A
authors.initials: A
authors.lastname: Velez
authors.forename: L
authors.initials: L
authors.lastname: Carvajal-Carmona
authors.forename: R
authors.initials: R
authors.lastname: Scott
authors.forename: S
authors.initials: S
authors.lastname: Penegar
authors.forename: P
authors.initials: P
authors.lastname: Broderick
authors.forename: A
authors.initials: A
authors.lastname: Tenesa
authors.forename: R S
authors.initials: RS
authors.lastname: Houlston
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D019683:Penetrance; D011110:Polymorphism, Genetic; D011379:Prognosis; D012306:Risk; D012307:Risk Factors