title: Successful resolution of severe hepatopulmonary syndrome following liver transplantation.
abstract: Hepatopulmonary syndrome (HPS) is a complication of portal hypertension, defined by the presence of liver disease, abnormal pulmonary gas exchange and evidence of intrapulmonary vascular dilatations producing a right-to-left intrapulmonary shunt. Liver transplantation (LT) is the treatment of choice; however, severe hypoxemia (PaO(2) < 50 mmHg on room air) is considered a contraindication to LT. This approach disadvantages some patients, particularly young patients with no intrinsic cardio-respiratory disease. We discuss one such patient who improved with LT despite having extremely severe HPS (PaO2 < 29 mmHg).
authors.affiliation: Department of Surgery, University of Alberta, Edmonton, AB, Canada.
authors.forename: Sonal
authors.initials: S
authors.lastname: Asthana
authors.forename: Connor
authors.initials: C
authors.lastname: Maguire
authors.forename: Lawrence
authors.initials: L
authors.lastname: Lou
authors.forename: Michael
authors.initials: M
authors.lastname: Meier
authors.forename: Vincent
authors.initials: V
authors.lastname: Bain
authors.forename: Derek R
authors.initials: DR
authors.lastname: Townsend
authors.forename: Rex
authors.initials: R
authors.lastname: Townsend
authors.forename: Dale
authors.initials: D
authors.lastname: Lien
authors.forename: David
authors.initials: D
authors.lastname: Bigam
authors.forename: Norman
authors.initials: N
authors.lastname: Kneteman
authors.forename: Andrew Mark James
authors.initials: AM
authors.lastname: Shapiro
mesh_terms: D000022:Abortion, Spontaneous; D000293:Adolescent; D005260:Female; D006085:Graft Survival; D020065:Hepatopulmonary Syndrome / Q000628:therapy*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000628:therapy; D000860:Hypoxia; D016031:Liver Transplantation / Q000379:methods*; D010100:Oxygen / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications; D011312:Pressure; D011659:Pulmonary Gas Exchange; D016896:Treatment Outcome
chemical_list: D010100:Oxygen