title: Targeted hyperthermia using metal nanoparticles.
abstract: Despite the use of hyperthermia to treat cancer for thousands of years, the challenge of only heating malignant cells remains daunting. In pre-clinical and early clinical trials, metal nanoparticles induce hyperthermic cytotoxicity when exposed to near-infrared radiation or radiofrequency fields. We discuss the emerging roles of nanoparticles, especially gold, in the hyperthermic treatment of cancer. In addition, we discuss the similarities of radiofrequency ablation and nanoparticle mediated cytotoxicity.
authors.affiliation: The Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Cherukuri
authors.forename: Evan S
authors.initials: ES
authors.lastname: Glazer
authors.forename: Steven A
authors.initials: SA
authors.lastname: Curley
mesh_terms: D017115:Catheter Ablation / Q000379:methods; D002986:Clinical Trials as Topic; D006046:Gold / Q000737:chemistry; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D053768:Metal Nanoparticles / Q000008:administration & dosage*; D036103:Nanotechnology / Q000379:methods; D009369:Neoplasms / Q000628:therapy*
chemical_list: D006046:Gold