Genome-wide association studies of family data in pharmacogenetics: a case study.
Genome-wide associations studies (GWAS) have become routine in human genetics research; however the application of GWAS to pharmacogenomics research is just beginning. As these studies make their way into pharmacogenetics, there are several considerations specific to pharmacogenetics that should be made. In this manuscript, we discuss these considerations and provide concrete examples with GWAS data for an asthma clinical trial using parent-offspring trios.
Murphy
Amy
A
Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Lasky-Su
Jessica
J
Tantisira
Kelan G
KG
Litonjua
Augusto A
AA
Lange
Christoph
C
Weiss
Scott T
ST
D018927:Anti-Asthmatic Agents / Q000494:pharmacology; D001249:Asthma / Q000188:drug therapy* / Q000235:genetics; D002986:Clinical Trials as Topic; D055106:Genome-Wide Association Study; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D010597:Pharmacogenetics / Q000379:methods*; D010641:Phenotype
D018927:Anti-Asthmatic Agents