title: Imaging findings in a fatal case of pandemic swine-origin influenza A (H1N1).
abstract: OBJECTIVE
  Although most cases of swine-origin influenza A (H1N1) virus (S-OIV) have been self-limited, fatal cases raise questions about virulence and radiology's role in early detection. We describe the radiographic and CT findings in a fatal S-OIV infection.
  
  
  CONCLUSIONS
  Radiography showed peripheral lung opacities. CT revealed peripheral ground-glass opacities suggesting peribronchial injury. These imaging findings raised suspicion of S-OIV despite negative H1N1 influenza rapid antigen test results from two nasopharyngeal swabs; subsequently, those results were proven to be false-negatives by reverse transcriptase polymerase chain reaction. This case suggests a role for CT in the early recognition of severe S-OIV.
authors.affiliation: Department of Radiology and Imaging Sciences, National Institutes of Health, Clinical Center, Bethesda, MD, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Mollura
authors.forename: Deborah S
authors.initials: DS
authors.lastname: Asnis
authors.forename: Robert S
authors.initials: RS
authors.lastname: Crupi
authors.forename: Rick
authors.initials: R
authors.lastname: Conetta
authors.forename: David S
authors.initials: DS
authors.lastname: Feigin
authors.forename: Mike
authors.initials: M
authors.lastname: Bray
authors.forename: Jeffery K
authors.initials: JK
authors.lastname: Taubenberger
authors.forename: David A
authors.initials: DA
authors.lastname: Bluemke
mesh_terms: D017809:Fatal Outcome; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed