title: Fetal nuchal cystic hygroma associated with aortic coarctation and trisomy 21: a case report.
abstract: We report a case of fetal nuchal cystic hygroma associated with aortic coarctation and trisomy 21. A stillborn baby, delivered at 15 weeks and 5 days of gestation, had a huge nuchal cystic hygroma. Autopsy revealed aortic coarctation of the periductal type with patent ductus arteriosus, endocardial cushion defect and left ventricular hypoplasia. Trisomy 21 was evident by karyotyping. Macroscopically, while an apparent association of nuchal cystic hygroma and aortic coarctation resembled Turner syndrome, histopathological findings were those typically seen in trisomy 21: numerous dilated lymphatics in the subcutaneous tissue with severe mesenchymal edema, and an enlarged jugular lymphatic sac.
authors.affiliation: Division of Pathology (Diagnostic Molecular Pathology Unit), Kobe University Graduate School of Medicine 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017 Japan. kitazawa@med.kobe-u.ac.jp
authors.forename: Sohei
authors.initials: S
authors.lastname: Kitazawa
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Mori
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kondo
authors.forename: Riko
authors.initials: R
authors.lastname: Kitazawa