title: Physicochemical characterization of solid dispersion systems of tadalafil with poloxamer 407.
abstract: Dissolution behaviour of a poorly water-soluble drug, tadalafil, from its solid dispersion systems with poloxamer 407 has been investigated. Solid dispersion systems of tadalafil were prepared with poloxamer 407 in 1:0.5, 1:1.5 and 1:2.5 ratios using the melting method. Characterization of binary systems with FTIR and XRPD studies demonstrated the presence of strong hydrogen bonding interactions, a significant decrease in crystallinity and the possibility of existence of amorphous entities of the drug. In the binary systems tested, 1:0.5 proportion of tadalafil/poloxamer 407 showed rapid dissolution of tadalafil (DE(30) 70.9 + or - 3.6 %). In contrast, higher proportions of poloxamer 407 (1:1.5 and 1:2.5) offered no advantage towards dissolution enhancement of the drug, indicating altered rheological characteristics of the polymer at its higher concentration, which might have retarded the release rate of tadalafil.
authors.affiliation: Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad Maharashtra-415124, India.
authors.forename: Vikrant
authors.initials: V
authors.lastname: Vyas
authors.forename: Pankajkumar
authors.initials: P
authors.lastname: Sancheti
authors.forename: Poonam
authors.initials: P
authors.lastname: Karekar
authors.forename: Manali
authors.initials: M
authors.lastname: Shah
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Pore
mesh_terms: D002243:Carbolines / Q000737:chemistry*; D003460:Crystallization; D006860:Hydrogen Bonding; D014677:Pharmaceutical Vehicles / Q000737:chemistry; D020442:Poloxamer / Q000737:chemistry*; D012995:Solubility; D000068581:Tadalafil
chemical_list: D002243:Carbolines; D014677:Pharmaceutical Vehicles; D020442:Poloxamer; D000068581:Tadalafil