title: Nicotinamide N-Methyltransferase upregulation correlates with tumour differentiation in oral squamous cell carcinoma.
abstract: We investigated expression levels of Nicotinamide N-Methyltransferase (NNMT), an enzyme involved in the biotransformation of many drugs and xenobiotic compounds, in oral squamous cell carcinoma (OSCC). Measurements were performed by immunohistochemistry and the relationship between tumour characteristics and NNMT levels in OSCC was studied to evaluate the effectiveness of NNMT as a prognostic marker in squamous cell carcinoma of the oral cavity. In conclusion, the present study suggests that NNMT may have potential as a biomarker and as a therapeutic target for OSCC.
authors.affiliation: Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Ancona, Italy. m.emanuelli@univpm.it
authors.forename: Monica
authors.initials: M
authors.lastname: Emanuelli
authors.forename: Andrea
authors.initials: A
authors.lastname: Santarelli
authors.forename: Davide
authors.initials: D
authors.lastname: Sartini
authors.forename: Domenico
authors.initials: D
authors.lastname: Ciavarella
authors.forename: Valentina
authors.initials: V
authors.lastname: Rossi
authors.forename: Valentina
authors.initials: V
authors.lastname: Pozzi
authors.forename: Corrado
authors.initials: C
authors.lastname: Rubini
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Lo Muzio
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000473:pathology*; D002454:Cell Differentiation / Q000502:physiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000201:enzymology* / Q000473:pathology*; D050903:Nicotinamide N-Methyltransferase / Q000096:biosynthesis*; D011379:Prognosis; D016610:Tissue Embedding; D016707:Tissue Fixation; D015854:Up-Regulation
chemical_list: D050903:Nicotinamide N-Methyltransferase