title: Pharmacokinetics of ertapenem following intravenous and subcutaneous infusions in patients.
abstract: Steady-state pharmacokinetics of ertapenem were compared in patients after 1-g intravenous and subcutaneous (s.c.) infusions. Bioavailability was 99%+/-18% after s.c. administration, but peaks were reduced by about (43+/-29 versus 115+/-28 microg/ml) and times to peak were delayed. Simulations based on unbound concentrations show that time over the MIC should always be longer than 30% to 40% of the dosing interval, suggesting that s.c. infusion could be an alternative in patients with reduced vascular access.
authors.affiliation: INSERM, ERI-23, Pôle Biologie Santé, 40 Avenue du Recteur Pineau, Poitiers, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Frasca
authors.forename: Sandrine
authors.initials: S
authors.lastname: Marchand
authors.forename: Franck
authors.initials: F
authors.lastname: Petitpas
authors.forename: Claire
authors.initials: C
authors.lastname: Dahyot-Fizelier
authors.forename: William
authors.initials: W
authors.lastname: Couet
authors.forename: Olivier
authors.initials: O
authors.lastname: Mimoz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000077727:Ertapenem; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods*; D055104:Infusions, Subcutaneous / Q000379:methods*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D055815:Young Adult; D047090:beta-Lactams / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D000077727:Ertapenem