title: Hymenopsins A and B and a macrophorin analogue from a fungicolous Hymenopsis sp.
abstract: Hymenopsin A (1), hymenopsin B (2), and a new macrophorin analogue, 2',3'-epoxy-13-hydroxy-4'-oxomacrophorin A (3), have been isolated from a fungicolous isolate of Hymenopsis sp. (MYC-1703; NRRL 37638). The structures and relative configurations of these compounds were assigned on the basis of 2D NMR and MS data, and the identity of 1 was confirmed by X-ray crystallographic analysis. The absolute configuration of 2 was proposed on the basis of CD analysis using both empirical and computational methods. Compounds 2 and 3 showed antibacterial activity against Staphylococcus aureus and Bacillus subtilis. Compound 3 was also active against Aspergillus flavus and Fusarium verticillioides.
authors.affiliation: Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Lori E
authors.initials: LE
authors.lastname: Schmidt
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Deyrup
authors.forename: Jonas
authors.initials: J
authors.lastname: Baltrusaitis
authors.forename: Dale C
authors.initials: DC
authors.lastname: Swenson
authors.forename: Donald T
authors.initials: DT
authors.lastname: Wicklow
authors.forename: James B
authors.initials: JB
authors.lastname: Gloer
mesh_terms: D001412:Bacillus subtilis / Q000187:drug effects; D018360:Crystallography, X-Ray; D005658:Fungi / Q000737:chemistry*; D006254:Hawaii; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: C438425:4'-oxomacrophorin A; D012717:Sesquiterpenes; C548919:hymenopsin A; C548920:hymenopsin B