title: BMAA neurotoxicity in Drosophila.
abstract: We report the establishment of an in vivo model using the fruit fly Drosophila melanogaster to investigate the toxic effects of L-BMAA. We found that dietary intake of BMAA reduced the lifespan as well as the neurological functions of flies. Furthermore, we have developed an HPLC method to reliably detect both free and protein-bound BMAA in fly tissue extracts.
authors.affiliation: Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
authors.forename: Xianchong
authors.initials: X
authors.lastname: Zhou
authors.forename: Wilfredo
authors.initials: W
authors.lastname: Escala
authors.forename: Spyridon
authors.initials: S
authors.lastname: Papapetropoulos
authors.forename: Walter G
authors.initials: WG
authors.lastname: Bradley
authors.forename: R Grace
authors.initials: RG
authors.lastname: Zhai
mesh_terms: D000409:Alanine / Q000494:pharmacology; D000599:Amino Acids, Diamino / Q000008:administration & dosage* / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D000087522:Cyanobacteria Toxins; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster; D005260:Female; D018698:Glutamic Acid / Q000494:pharmacology; D007930:Leucine / Q000627:therapeutic use; D008136:Longevity / Q000187:drug effects; D008239:Lysine / Q000627:therapeutic use; D008297:Male; D020258:Neurotoxicity Syndromes / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology*; D009498:Neurotoxins / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000599:Amino Acids, Diamino; D000087522:Cyanobacteria Toxins; D009498:Neurotoxins; C001824:beta-N-methylamino-L-alanine; D018698:Glutamic Acid; D007930:Leucine; D008239:Lysine; D000409:Alanine