Functional polymorphism of cytotoxic T-lymphocyte antigen 4 and nasopharyngeal carcinoma susceptibility in a Chinese population.
Cytotoxic T-lymphocyte antigen 4 (CTLA-4; CD152) is a secondary receptor of B7 (CD80 and CD86) and shares homology with the CD28 receptor. Although the structures of CTLA-4 and CD28 are very similar, they deliver different costimulatory signals. A functional polymorphism in CTLA-4 exon 1 position +49 that can affect the T-cell response has been reported by several groups. Previous case-control studies also revealed this polymorphism contribute to the risk of autoimmune diseases and common cancers. However, the relationship between CTLA-4 functional polymorphism and nasopharyngeal carcinoma (NPC) susceptibility has not yet been explored. In this study, we performed a case-control study in a Chinese population. Our result showed that the CTLA-4 +49 A>G polymorphism is associated with NPC susceptibility. The subjects carrying the CTLA-4 +49 AA genotype have a approximately 1.8-fold increased risk of NPC (adjust OR 1.83; 95% CI, 1.16-2.93) when compared with the GG genotype.
Xiao
M
M
Department of Otorhinolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital, ZheJiang University, HangZhou, China.
Qi
F
F
Chen
X
X
Luo
Z
Z
Zhang
L
L
Zheng
C
C
Hu
S
S
Jiang
X
X
Zhou
M
M
Tang
J
J
D000328:Adult; D017677:Age Distribution; D000368:Aged; D015703:Antigens, CD / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D060908:CTLA-4 Antigen; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human