title: A mild and efficient synthesis of monofluorinated α-lactam pseudopeptides via a novel dehydrofluorination of Ugi products.
abstract: Six novel monofluorinated α-lactam pseudopeptide derivatives were synthesized via Ugi reaction using gem-difluoromethylene-containing isocyanide as a key component, followed by dehydrofluorination of Ugi products in one pot without additional base.
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, Center of Fluorine Chemical Technology, School of Pharmacy, East China University of Science and Technology, 200237, Shanghai, China.
authors.forename: Nianjin
authors.initials: N
authors.lastname: Liu
authors.forename: Song
authors.initials: S
authors.lastname: Cao
authors.forename: Jingjing
authors.initials: J
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.forename: Jinlong
authors.initials: J
authors.lastname: Yu
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Xuhong
authors.initials: X
authors.lastname: Qian
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D054879:Halogenation; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents / Q000737:chemistry
chemical_list: D007769:Lactams; D010455:Peptides; D012997:Solvents