Prevalence of prothrombotic polymorphisms in a selected cohort of cryptogenic and noncryptogenic ischemic stroke patients.
Ischemic stroke is a complex multifactorial disease and approximately 30%, especially in the young, are cryptogenic. In some of the patients with cryptogenic ischemic stroke the underlying risk factor may be a prothrombotic state. We studied 101 patients with ischemic stroke under 55 years of age. All the patients underwent an extensive diagnostic evaluation to determine the cause of stroke. Common variations in the genes encoding factor V, prothrombin, 5,10-methylenetetrahydrofolate reductase, plasminogen activator inhibitor-1, and human platelet alloantigens-1 were evaluated. Of the 101 patients with ischemic stroke, 28 patients had cryptogenic ischemic stroke. At least one of the different genetic polymorphisms investigated was present in 44% patients in the total group and in 48% of patients with cryptogenic ischemic stroke. In this study population under 55 years of age there was no significant difference in the prevalence of various genetic polymorphisms, factor V, prothrombin, 5,10-methylenetetrahydrofolate reductase, plasminogen activator inhibitor-1, and human platelet alloantigens) in patients with cryptogenic ischemic stroke and in patients with ischemic stroke of determined cause.
Calabrò
Rocco Salvatore
RS
IRCCS Centro Neurolesi Bonino-Pulejo, Cda Casazza, Messina, Italy. salbro77@tiscali.it
La Spina
Paolino
P
Serra
Salvatore
S
Laganà
Angelina
A
Postorino
Paolo
P
Savica
Rodolfo
R
Mammì
Corrado
C
Laganà
Carmelo
C
Musolino
Rosa
R
D000293:Adolescent; D000328:Adult; D016824:Antigens, Human Platelet / Q000235:genetics; D015331:Cohort Studies; D005165:Factor V / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D015995:Prevalence; D011516:Prothrombin / Q000235:genetics*; D012189:Retrospective Studies; D020521:Stroke / Q000150:complications / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics*; D055815:Young Adult
D016824:Antigens, Human Platelet; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)