title: Atypical acute leukemia early after liver transplantation.
abstract: Acute myeloid leukemia (AML) has been rarely reported after transplantation, namely seven cases described so far. The putative mechanism of action is long-standing immunosuppression, even though no clear correlation with the type of drug has ever been demonstrated. We report the case of a 28-year-old male patient who presented with a early onset of AML after liver transplantation for hepatitis B virus-related acute liver failure. The AML was characterized by aggressive clinical features with extrahematologic sites of involvement and an atypical immunophenotype; the laboratory findings were consistent with the diagnosis of monocytic acute leukemia.
authors.affiliation: Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Mannelli
authors.forename: P
authors.initials: P
authors.lastname: De Simone
authors.forename: G
authors.initials: G
authors.lastname: Gianfaldoni
authors.forename: C
authors.initials: C
authors.lastname: Nozzoli
authors.forename: F
authors.initials: F
authors.lastname: Filipponi
authors.forename: A
authors.initials: A
authors.lastname: Bosi
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001853:Bone Marrow / Q000473:pathology; D006680:HLA Antigens / Q000235:genetics; D006509:Hepatitis B / Q000601:surgery; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D017093:Liver Failure / Q000601:surgery* / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D016896:Treatment Outcome; D014682:Vena Cava, Inferior / Q000473:pathology
chemical_list: D006680:HLA Antigens