title: Unexplained fetal loss: the fetal side of thrombophilia.
abstract: Carrier status of the fetus for factor V polymorphism or double homozygosity for mutant alleles of the PAI-1 4 G/4 G and MTHFR T677 T polymorphisms must be considered risk factors for intrauterine fetal death. The clinical implications of these data need to be addressed in a prospective study to confirm our preliminary data and to answer the question of whether or not double homozygous individuals should be treated with low molecular-weight heparin and/or low-dose aspirin.
authors.affiliation: Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy.
authors.forename: Andrea Luigi
authors.initials: AL
authors.lastname: Tranquilli
authors.forename: Franca
authors.initials: F
authors.lastname: Saccucci
authors.forename: Stefano Raffaele
authors.initials: SR
authors.lastname: Giannubilo
authors.forename: Monia
authors.initials: M
authors.lastname: Cecati
authors.forename: Linda
authors.initials: L
authors.lastname: Nocchi
authors.forename: Sara
authors.initials: S
authors.lastname: Lorenzi
authors.forename: Monica
authors.initials: M
authors.lastname: Emanuelli
mesh_terms: D000328:Adult; D005165:Factor V / Q000235:genetics; D005260:Female; D005313:Fetal Death / Q000175:diagnosis / Q000235:genetics*; D005315:Fetal Diseases; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000235:genetics*; D019851:Thrombophilia / Q000175:diagnosis / Q000235:genetics*
chemical_list: D005165:Factor V