Medium to long-term results after reconstruction of bone defects at the knee with tumor endoprostheses.
OBJECTIVE
Limb salvage and reconstruction with tumor endoprostheses is considered as therapeutic standard in the treatment of bone defects at the knee. Few studies report long-term results so far.


METHODS
Seventy-seven patients who had a cementless or cemented MUTARS endoprosthesis implanted were followed-up for a mean period of 46 months (3-128 months). The defects were due to primary tumor lesions in 69 cases or metastases in 8 cases. The distal femur (n = 49) or the proximal tibia (n = 28) was reconstructed predominantly with cementless implants (femur: 69%, tibia: 92%). The resection of the tumor was intraarticular in 46 and extraarticular in 31 patients.


RESULTS
After 10 years probability of limb salvage was 92% with a recurrence rate of 3%. Complications were frequent with a revision rate of 58% and lead to a cumulative probability of survival of the initially implanted prosthesis of 57% after 5 years. Locking mechanism failure (n = 15) and aseptic loosening (n = 13) were the most frequent failure modes.


CONCLUSIONS
Regardless of achieving a low recurrence rate and satisfactory functional results, we found a high complication rate after implantation of a megaprosthesis. This was particularly evident for extraarticular resections and cemented fixation, which should be avoided when possible.
Kinkel
S
S
Department of Orthopaedics, University of Heidelberg, 69118 Heidelberg, Germany.
Lehner
B
B
Kleinhans
J A
JA
Jakubowitz
E
E
Ewerbeck
V
V
Heisel
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000601:surgery*; D002648:Child; D005260:Female; D005269:Femur; D006801:Humans; D007717:Knee / Q000601:surgery*; D007720:Knee Prosthesis; D023821:Limb Salvage; D008297:Male; D008875:Middle Aged; D013977:Tibia; D013997:Time Factors; D016896:Treatment Outcome