Antioxidation and DNA-binding properties of binuclear Er(III) complexes with Schiff-base ligands derived from 8-hydroxyquinoline-2-carboxaldehyde and four aroylhydrazines.
The Er(III) complexes are prepared from Er(NO(3))(3).6H(2)O and Schiff-base ligands derived from 8-hydroxyquinoline-2-carboxaldehyde with four aroylhydrazines, including benzoylhydrazine, 2-hydroxybenzoylhydrazine, 4-hydroxybenzoylhydrazine and isonicotinylhydrazine, respectively. X-ray crystal and other structural analyses indicate that Er(III) and every ligand can form a binuclear Er(III) complex with nine-coordination and 1: 1 metal-to-ligand stoichiometry at the Er(III) centre. All the Er(III) complexes can bind to calf thymus DNA through intercalation with the binding constants at the order of magnitude 10(6) M(-1), and they may be used as potential anticancer drugs. All the Er(III) complexes have strong scavenging effects for hydroxyl radicals and superoxide radicals; however, complex containing active phenolic hydroxyl group shows stronger scavenging effects for hydroxyl radicals and complex containing N-heteroaromatic substituent shows stronger scavenging effects for superoxide radicals.
Liu
Yong-Chun
YC
College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, P.R. China.
Yang
Zheng-Yin
ZY
D000447:Aldehydes / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism; D002417:Cattle; D056831:Coordination Complexes / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D004871:Erbium; D016166:Free Radical Scavengers / Q000737:chemistry / Q000378:metabolism; D006834:Hydrazines / Q000737:chemistry*; D062385:Hydroxybenzoates / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D010084:Oxidation-Reduction; D015125:Oxyquinoline / Q000031:analogs & derivatives* / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry*
D000447:Aldehydes; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D016166:Free Radical Scavengers; D006834:Hydrazines; D062385:Hydroxybenzoates; D008024:Ligands; D012545:Schiff Bases; C002429:4-hydroxybenzoic acid hydrazide; D015125:Oxyquinoline; D004871:Erbium; D004247:DNA; C427203:calf thymus DNA; C006712:benzoylhydrazine