title: Influence of intrastriatal infusion of dynorphin fragments on overflow of acetylcholine and dopamine in the rat brain.
abstract: Dynorphin (DYN) fragments are the members of the endogenous opioid system and postulated ligands for the opioid receptors. Infusion of DYN(1-17) fragment into the rat dorsal striatum caused a significant increase in acetylcholine and decrease in dopamine overflow. Contrary to this, infusions of DYN(2-17) fragment into the rat dorsal striatum caused a significant increase in dopamine and decrease in acetylcholine overflow. Intrastriatal infusions of different doses of the acetylcholinesterase blocker, neostigmine, augmented acetylcholine and inhibited dopamine overflow in a dose-dependent manner. The opposing responses of the DYN fragments suggest that the N-terminal residue plays a key role in presynaptic neuromodulation.
authors.affiliation: Department of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA. amar.pani@stjude.org
authors.forename: Amar K
authors.initials: AK
authors.lastname: Pani
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000378:metabolism*; D004399:Dynorphins / Q000008:administration & dosage / Q000494:pharmacology*; D004563:Electrochemistry; D008297:Male; D017551:Microdialysis; D008845:Microinjections; D009388:Neostigmine / Q000494:pharmacology; D017072:Neostriatum / Q000033:anatomy & histology / Q000502:physiology*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017661:Receptors, Presynaptic / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D002800:Cholinesterase Inhibitors; D010446:Peptide Fragments; D017661:Receptors, Presynaptic; D009388:Neostigmine; D004399:Dynorphins; D000109:Acetylcholine; D004298:Dopamine