Comparative study of immunocorrective activity of phenibut and its organic salts in experimental immunodeficiency.
Phenibut and its derivatives normalized cellular (index of delayed-type hypersensitivity reaction) and humoral (antierythrocyte antibody titer) immunity and the lymphoproliferative processes in immunocompetent organs of animals with cyclophosphamide-induced immunosuppression. This indicates pronounced immunocorrective effects of these substances.
Tyurenkov
I N
IN
Department of Pharmacology and Biopharmaceutics, Faculty of Postgraduate Medical Education, Volgograd State Medical University, Russia. fibfuv@mail.ru
Samotrueva
M A
MA
D000276:Adjuvants, Immunologic / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects; D056724:Immunity, Humoral / Q000187:drug effects; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D007166:Immunosuppressive Agents; D005680:gamma-Aminobutyric Acid; D003520:Cyclophosphamide; C008842:4-amino-3-phenylbutyric acid