title: Takotsubo cardiomyopathy following radioiodine therapy for toxic multinodular goitre.
abstract: We report on a 73-year-old man with a toxic multinodular goitre, which was treated with radioiodine therapy (I-131) without pretreatment with an antithyroid drug. Four weeks later he presented with rapidly progressive dyspnoea and a significant increase in free thyroxin. The electrocardiogram showed ST -segment elevation, and echocardiography demonstrated apical akinesia and a left ventricular ejection fraction of only 25%. However, direct coronary catheterisation showed no evidence of coronary artery disease. Left ventricular angiography showed apical ballooning consistent with the diagnosis of takotsubo cardiomyopathy. Following treatment of the cardiomyopathy and thyrotoxicosis, he experienced a complete recovery. To the best of our knowledge, this is the first report of a takotsubo cardiomyopathy associated with thyrotoxicosis resulting from radiation thyroiditis induced by radioiodine. Three other cases of takotsubo cardiomyopathy associated with Graves' disease have been described in literature.
authors.affiliation: Department of Hematology, University Medical Centre Utrecht, the Netherlands. n.w.c.j.vandedonk@umcutrecht.nl
authors.forename: N W C J
authors.initials: NW
authors.lastname: van de Donk
authors.forename: Y G C J
authors.initials: YG
authors.lastname: America
authors.forename: P M J
authors.initials: PM
authors.lastname: Zelissen
authors.forename: B J B
authors.initials: BJ
authors.lastname: Hamer
mesh_terms: D000368:Aged; D004417:Dyspnea; D006044:Goiter, Nodular / Q000532:radiotherapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D011832:Radiation Injuries / Q000150:complications / Q000209:etiology*; D012307:Risk Factors; D013318:Stroke Volume; D054549:Takotsubo Cardiomyopathy / Q000209:etiology*; D013971:Thyrotoxicosis / Q000150:complications / Q000209:etiology*; D013974:Thyroxine / Q000378:metabolism; D016277:Ventricular Function, Left
chemical_list: D007457:Iodine Radioisotopes; D013974:Thyroxine