Advanced oxidation protein products: a causative link between oxidative stress and podocyte depletion.
Advanced oxidation protein products (AOPPs), a protein biomarker of increased oxidative stress, are elevated in uremic patients. Zhou et al. demonstrate that chronic administration of AOPPs induces podocyte apoptosis and proteinuria in normal rats via a cascade of signaling events. This study for the first time establishes a causative link between oxidative stress and podocyte depletion and could have broad implications in our understanding of the pathogenic mechanism of proteinuria.
Liu
Youhua
Y
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA. liuy@upmc.edu
D000818:Animals; D018384:Oxidative Stress; D050199:Podocytes / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*; D051381:Rats
D011506:Proteins