Antiretroviral therapy for control of the HIV-associated tuberculosis epidemic in resource-limited settings.
Great progress has been made over the past few years in HIV testing in patients who have tuberculosis (TB) and in the scale-up of antiretroviral therapy. More than 3 million people in resource-limited settings were estimated to have started antiretroviral therapy by the end of 2007 and 2 million of these were in sub-Saharan Africa. However, little is known about what impact this massive public health intervention will have on the HIV-associated TB epidemic or how antiretroviral therapy might be used to best effect TB control. This article provides an in-depth review of these issues.
Lawn
Stephen D
SD
The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa. stevelawn@yahoo.co.uk
Kranzer
Katharina
K
Wood
Robin
R
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology* / Q000517:prevention & control*; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D014943:Global Health; D006801:Humans; D009017:Morbidity; D014376:Tuberculosis / Q000453:epidemiology* / Q000517:prevention & control*
D044966:Anti-Retroviral Agents