Novel lead for potent inhibitors of breast cancer resistance protein (BCRP).
From our modulator library an interesting inhibitor of breast cancer resistance protein (BCRP) was identified. Due to its high inhibitory potency, this compound may serve as a promising novel lead for the design of new and potent modulators. This adds a new structural class to the few known highly active BCRP inhibitors.
Pick
Anne
A
Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
Müller
Henrik
H
Wiese
Michael
M
D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors* / Q000378:metabolism; D001549:Benzamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001562:Benzimidazoles / Q000378:metabolism; D045744:Cell Line, Tumor; D002734:Chlorophyll / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D008968:Molecular Conformation; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010671:Phenylurea Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D054852:Small Molecule Libraries
C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D001549:Benzamides; D001562:Benzimidazoles; D009363:Neoplasm Proteins; D010671:Phenylurea Compounds; D054852:Small Molecule Libraries; D002734:Chlorophyll; C032623:pheophorbide a; C017807:bisbenzimide ethoxide trihydrochloride