Hair mercury levels, fish consumption, and cognitive development in preschool children from Granada, Spain .
The main source of human exposure to mercury is the consumption of fish contaminated with methylmercury, which may adversely affect early neurodevelopment. This study assessed mercury levels in hair of preschoolers in Spain, where fish consumption is elevated, with the aim of investigating the influence of their fish intake and other factors on mercury exposure, and evaluating their association with cognitive development. A population-based birth cohort from Granada (Spain) was studied at the age of 4yr. Total mercury (T-Hg) levels were determined in children's hair, and daily fish intake was assessed by a food frequency questionnaire. The McCarthy Scales of Children's Abilities (MSCA) were used to assess children's motor and cognitive abilities. Complete data were gathered on 72 children, and multivariate analyses were performed to evaluate the influence of mercury exposure and fish intake on MSCA outcomes. Mean concentration of T-Hg in hair was 0.96 microg/g (95% confidence interval=0.76; 1.20 microg/g). T-Hg levels were associated with higher frequency of oily fish consumption, place of residence, maternal age, and passive smoking. After adjustment for fish intake, T-Hg levels > or =1microg/g were associated with decrements in the general cognitive (-6.6 points), memory (-8.4 points), and verbal (-7.5 points) MSCA scores. Higher mercury exposure in children from this Mediterranean area was associated with cognitive development delay. Studies on the putative benefits of fish intake during early development should consider mercury exposure from different fish species.
Freire
Carmen
C
Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, CIBER de Epidemiología y Salud Pública (CIBERESP), 18071 Granada, Spain. cfreire@ugr.es
Ramos
Rosa
R
Lopez-Espinosa
Maria-Jose
MJ
Díez
Sergi
S
Vioque
Jesús
J
Ballester
Ferrán
F
Fernández
Mariana-Fátima
MF
D000818:Animals; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D002947:Cities; D003071:Cognition / Q000187:drug effects*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004435:Eating; D004784:Environmental Monitoring; D005399:Fishes; D006197:Hair / Q000737:chemistry*; D006801:Humans; D008628:Mercury / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D008767:Methylmercury Compounds / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity; D015999:Multivariate Analysis; D012424:Rural Population / Q000706:statistics & numerical data; D013030:Spain; D014505:Urban Population / Q000706:statistics & numerical data; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*
D008767:Methylmercury Compounds; D014874:Water Pollutants, Chemical; D008628:Mercury