title: Angiotensinogen polymorphisms and acquired atrial fibrillation in Chinese.
abstract: Genetic predisposition may be underlying the prevalence of acquired atrial fibrillation (AF). We investigated the association between polymorphism in angiotensinogen (AGT) and angiotensin-converting enzyme gene and risk of acquired AF in a pair-matched case-control study conducted in Chinese Hans. We selected 9 single nucleotide polymorphisms (SNPs) in the AGT gene and 3 SNPs in the angiotensin-converting enzyme gene using a tagging-SNP strategy. We observed significant association between tagging-SNP rs699 (M235T), located in exon 2 of the AGT gene, and AF. The AA genotype of rs699 increased the risk of AF by 70% (95% confidence interval, 1.01-2.85; P = .044) under a recessive model (AA vs AG + GG). The significance remained after controlling for covariates age, smoking, body mass index, hypertension, diabetes, and left atrial dimension, with an increased risk of AF by 90% (95% confidence interval, 1.04-3.46; P = .036). We provide evidence that polymorphism in AGT gene may confer predisposition to acquired atrial fibrillation in Chinese Hans.
authors.affiliation: Department of Cardiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Qun-Shan
authors.initials: QS
authors.lastname: Wang
authors.forename: Yi-Gang
authors.initials: YG
authors.lastname: Li
authors.forename: Xing-Dong
authors.initials: XD
authors.lastname: Chen
authors.forename: Jie-Fei
authors.initials: JF
authors.lastname: Yu
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.forename: Shang-Biao
authors.initials: SB
authors.lastname: Lu
authors.forename: Li
authors.initials: L
authors.lastname: Jin
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Wang
mesh_terms: D000368:Aged; D000808:Angiotensinogen / Q000235:genetics*; D001281:Atrial Fibrillation / Q000453:epidemiology* / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D012083:Renin / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D000808:Angiotensinogen; D012083:Renin