title: [Pyoderma gangrenosum--clinical, laboratory and therapeutic approaches. Review of 28 cases].
abstract: Pyoderma gangrenosum is an uncommon neutrophilic dermatosis, idiopatic in 25-50 percent of cases. We present a retrospective study of 28 patients, admitted to Hospital de São João, EPE, between January of 1990 and June of 2008. Pyoderma gangrenosum was observed more frequently in middle age adults, in the ulcerated form, and predominantly localized in the lower limbs. Pediatric presentation was very rare. In 50 percent of these cases a systemic disease was present and the most frequent was Crohn disease (14% of patients).
authors.affiliation: Department of Dermatology and Venereology, Hospital de São João, Porto, Portugal. duarte.af.t30@gmail.com
authors.forename: Ana F
authors.initials: AF
authors.lastname: Duarte
authors.forename: Ana
authors.initials: A
authors.lastname: Nogueira
authors.forename: Carmen
authors.initials: C
authors.lastname: Lisboa
authors.forename: Filomena
authors.initials: F
authors.lastname: Azevedo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D015897:Comorbidity; D003424:Crohn Disease / Q000453:epidemiology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007871:Leg Ulcer / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology; D011174:Portugal / Q000453:epidemiology; D017511:Pyoderma Gangrenosum / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology; D012189:Retrospective Studies; D012883:Skin Ulcer / Q000209:etiology; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents