The use of a cytokine panel to define the long-term risk stratification of heart failure/death in patients presenting with chest pain to the emergency department.
OBJECTIVE
To determine if a cytokine panel could be informative regarding subsequent heart failure(HF)/death.


METHODS
In 216 subjects presenting with chest pain to an emergency department in 1996, EDTA plasma (-70 degrees C) was thawed for IL-6, MCP-1, IL-10, VEGF, EGF measurement.


RESULTS
Subjects with any three cytokines elevated were at higher risk for HF/death compared to those with < or = two cytokines elevated.


CONCLUSIONS
A cytokine panel might be useful for risk stratification for HF/death.
Kavsak
Peter A
PA
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. kavsakp@mcmaster.ca
Newman
Alice M
AM
Ko
Dennis T
DT
Macrae
Andrew R
AR
Jaffe
Allan S
AS
D000368:Aged; D002637:Chest Pain / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D003643:Death; D004636:Emergency Service, Hospital; D005260:Female; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013997:Time Factors
D016207:Cytokines