CXCL12/CXCR4 promotes motility and proliferation of glioma cells.
Glioblastoma (GBM) is the most aggressive and malignant brain tumor. Recent studies indicated that glioma samples are characterized by increased expression of CXCR4, the CXCL12/SDF-1 chemokine receptor. To better understand the role of CXCR4 in GBM biology we performed an integrated study where we simultaneously evaluate the contribution of the CXCR4/CXCL12 signaling pathway to the proliferation, survival and motility of a human GBM cell line. Our results indicated that CXCR4/CXCL12 axis induced an increase in cell proliferation and in cell motility. The blockage of CXCR4 induced a significant increase of apoptosis. Together, our results indicated that CXCR4/CXCL12 signalling pathway may contribute to GBM development and emphasize the therapeutic potential of this pathway in patients with GBM.
do Carmo
Anália
A
Centre for Neuroscience and Cell Biology and CIMAGO, University of Coimbra, Coimbra, Portugal. analiacarmo@gmail.com
Patricio
Inês
I
Cruz
Maria T
MT
Carvalheiro
Helena
H
Oliveira
Catarina R
CR
Lopes
Maria C
MC
D001932:Brain Neoplasms / Q000235:genetics*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D054377:Chemokine CXCL12 / Q000235:genetics / Q000378:metabolism*; D002633:Chemotaxis; D005909:Glioblastoma / Q000473:pathology; D005910:Glioma / Q000235:genetics*; D006801:Humans; D019718:Receptors, CXCR4 / Q000235:genetics / Q000378:metabolism*
D054377:Chemokine CXCL12; D019718:Receptors, CXCR4