Acute effects of pharmacotherapies in blood pressure in normotensive moderate smokers.
This study was designed to evaluate the changes in arterial blood pressure (BP) and heart rate (HR) in moderate smokers during smoking abstinence after 7 days of treatment with bupropion alone, transdermal nicotine or bupropion combined with transdermal nicotine. Twenty-four healthy moderate smokers (12 female/12 male; 40+/-7 years) were evaluated randomly on five occasions and their systolic, diastolic, mean arterial blood pressure (MAP) and HR were measured by a Finapres device for 10 h, immediately after smoking interruption. All of the 24 smokers participated on five protocols during 7 days: control group (C) - no drugs; placebo group (PL); bupropion group (BUP) 150-300 mg; transdermal nicotine group (TN) - 21 mg; and BUP+TN-nicotine patch. Concomitantly, the subjects were evaluated by ABPM (ambulatory BP monitoring). All of BP parameters monitored shown significant statistical differences in the BUP, TN and BUP+TN groups compared with the controls (p<0.05), when measured by Finapres. The HR remained unaltered in all of the groups. No significant differences were seen in the BP or HR during the 24-h ABPM. These findings indicate that in moderate smokers, bupropion, transdermal nicotine or bupropion associated with transdermal nicotine caused an elevation in the BP after acute smoking interruption.
Martins
Luíz Cláudio
LC
Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil.
Ferreira-Melo
Sílvia Elaine
SE
Sabha
Maricene
M
Coelho
Otávio Rizzi
OR
Yugar-Toledo
Juan Carlos
JC
Quinaglia
Thiago
T
Moreira
Marcos Mello
MM
Coca
Antonio
A
Moreno Júnior
Heitor
H
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D016642:Bupropion / Q000008:administration & dosage* / Q000009:adverse effects; D018592:Cross-Over Studies; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage* / Q000009:adverse effects; D016037:Single-Blind Method; D012907:Smoking / Q000503:physiopathology*; D016540:Smoking Cessation / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome
D016642:Bupropion; D009538:Nicotine