Cell adhesion molecules: role and clinical significance in cancer.
There is a growing body of evidence suggesting that alterations in the adhesion properties of neoplastic cells endow them with an invasive and migratory phenotype. Indeed, changes in the expression or function of cell adhesion molecules have been implicated in all steps of tumor progression, including detachment of tumor cells from the primary site, intravasation into the blood stream, extravasation into distant target organs, and formation of the secondary lesions. This review presents recent data regarding the role of cell adhesion molecules in tumor development and progress with concern to their clinical exploitation as potential biomarkers in neoplastic diseases.
Makrilia
Nektaria
N
Oncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens School of Medicine, Greece.
Kollias
Anastasios
A
Manolopoulos
Leonidas
L
Syrigos
Kostas
K
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism; D002448:Cell Adhesion / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002465:Cell Movement; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D016023:Integrins / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D014411:Neoplastic Stem Cells / Q000378:metabolism; D011237:Predictive Value of Tests; D011379:Prognosis; D011836:Radiation Tolerance; D019087:Selectins / Q000378:metabolism
D014408:Biomarkers, Tumor; D015820:Cadherins; D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; D016023:Integrins; D019087:Selectins