title: Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians.
abstract: BACKGROUND
  Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians.
  
  
  OBJECTIVE
  To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
  
  
  METHODS
  Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers.
  
  
  RESULTS
  Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele.
  
  
  CONCLUSIONS
  This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
authors.affiliation: Dr. Rasiklal Shah Sarvajanik Hospital, Modasa 383315, India. samarpan_research@yahoo.co.in
authors.forename: Timir Y
authors.initials: TY
authors.lastname: Mehta
authors.forename: Laxman M
authors.initials: LM
authors.lastname: Prajapati
authors.forename: Bharti
authors.initials: B
authors.lastname: Mittal
authors.forename: Chaitanya G
authors.initials: CG
authors.lastname: Joshi
authors.forename: Jayesh J
authors.initials: JJ
authors.lastname: Sheth
authors.forename: Dinesh B
authors.initials: DB
authors.lastname: Patel
authors.forename: Dinkar M
authors.initials: DM
authors.lastname: Dave
authors.forename: Ramesh K
authors.initials: RK
authors.lastname: Goyal
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D000927:Anticonvulsants / Q000009:adverse effects*; D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data; D002220:Carbamazepine / Q000009:adverse effects*; D002648:Child; D005260:Female; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000208:ethnology / Q000235:genetics*; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D015235:HLA-B Antigens; D002220:Carbamazepine