Glycan array: a powerful tool for glycomics studies.
Glycan arrays have become a powerful tool for the high-throughput elucidation of interactions of different carbohydrate structures with a wide variety of biological targets, including antibodies, proteins, viruses and cells. This technique is especially suitable for glycomics studies, because arrays present carbohydrate ligands in a manner that mimics interactions at cell-cell interfaces. This review assesses the recent advances involving glycan arrays, including new methods for glycan-array fabrication, new platforms for novel biological information, and new perceptions of glycomics for improving the understanding of disease-related glycobiology. Furthermore, this review attempts to forecast trends in the development of glycan arrays and possible solutions for some remaining challenges to improve this new technology.
Liang
Chi-Hui
CH
The Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan. jamesl@gate.sinica.edu.tw
Wu
Chung-Yi
CY
D000818:Animals; D054794:Glycomics / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D011134:Polysaccharides / Q000737:chemistry* / Q000378:metabolism*
D011134:Polysaccharides