title: Feasibility of low-volume injections of contrast material with a body weight-adapted iodine-dose protocol in 320-detector row coronary CT angiography.
abstract: OBJECTIVE
  To investigate the feasibility of low-volume injections of contrast material with a body weight-adapted iodine-dose protocol in computed tomography coronary angiography (CTCA) using a 320-detector row scanner.
  
  
  METHODS
  Ninety-eight patients who underwent CTCA in a single heartbeat with electrocardiogram-gating were divided into two groups, receiving 0.8 mL/kg of contrast material injected at a fixed duration of 12 seconds (A; n = 48) or 0.7 mL/kg of contrast material injected at a fixed duration of 10 seconds (B; n = 50); all patients then received 20 mL of saline. Contrast densities were assessed for the ascending aorta, left ventricle, right coronary artery (RCA), and left main coronary artery (LMA).
  
  
  RESULTS
  The mean flow rate was 4.00 + or - 0.56 mL/second in group A and 4.06 + or - 0.57 mL/second in group B (P = .51). There were no significant differences in the mean enhancement values of the ascending aorta, LMA and proximal RCA between the two groups. Also, there was no significant difference between the mean enhancement values at the three different levels of the RCA (proximal, middle, and distal segments) (group A; P = .27, group B; P = .07).
  
  
  CONCLUSIONS
  The use of 0.7 mL/kg of contrast material injected at a fixed duration of 10 seconds was feasible for CTCA using 320-detector row CT, with a sufficient and reliable contrast enhancement in the ascending aorta and coronary artery.
authors.affiliation: Department of Radiology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka 569-8686, Japan.
authors.forename: Fuminari
authors.initials: F
authors.lastname: Tatsugami
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Matsuki
authors.forename: Yuki
authors.initials: Y
authors.lastname: Inada
authors.forename: Shuji
authors.initials: S
authors.lastname: Kanazawa
authors.forename: Go
authors.initials: G
authors.lastname: Nakai
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takeda
authors.forename: Hideaki
authors.initials: H
authors.lastname: Morita
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Takada
authors.forename: Kenji
authors.initials: K
authors.lastname: Ashida
authors.forename: Shushi
authors.initials: S
authors.lastname: Yoshikawa
authors.forename: Katsunori
authors.initials: K
authors.lastname: Fukumura
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Narumi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001835:Body Weight; D003287:Contrast Media / Q000008:administration & dosage; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D004305:Dose-Response Relationship, Drug; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007479:Iopamidol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D011835:Radiation Protection / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; C057937:iomeprol; D007479:Iopamidol