Toll-like receptor 9: AEP takes control.
Toll-like receptor 9 (TLR9) requires proteolytic maturation to acquire signaling capacity; however, the involved protease(s) is unclear. In this issue of Immunity, Sepulveda et al. (2009) demonstrate that in dendritic cells, asparaginyl endopeptidase is a key protease that controls TLR9 maturation.
van Endert
Peter
P
Inserm, U580, Paris 75015, France. peter.van-endert@inserm.fr
D003546:Cysteine Endopeptidases / Q000502:physiology*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D008264:Macrophages / Q000276:immunology; D015398:Signal Transduction; D051217:Toll-Like Receptor 9 / Q000378:metabolism*; D000099240:Asparaginyl Endopeptidase
D003546:Cysteine Endopeptidases; D051217:Toll-Like Receptor 9; D000099240:Asparaginyl Endopeptidase