Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians.
BACKGROUND
Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians.


OBJECTIVE
To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.


METHODS
Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers.


RESULTS
Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele.


CONCLUSIONS
This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
Mehta
Timir Y
TY
Dr. Rasiklal Shah Sarvajanik Hospital, Modasa 383315, India. samarpan_research@yahoo.co.in
Prajapati
Laxman M
LM
Mittal
Bharti
B
Joshi
Chaitanya G
CG
Sheth
Jayesh J
JJ
Patel
Dinesh B
DB
Dave
Dinkar M
DM
Goyal
Ramesh K
RK
D000293:Adolescent; D000328:Adult; D000483:Alleles; D000927:Anticonvulsants / Q000009:adverse effects*; D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data; D002220:Carbamazepine / Q000009:adverse effects*; D002648:Child; D005260:Female; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000208:ethnology / Q000235:genetics*; D055815:Young Adult
D000927:Anticonvulsants; D015235:HLA-B Antigens; D002220:Carbamazepine