title: Spectral study of interaction between poly [acrylamide-(2-methyl acryloxyethyl) dimethyl buthylammonium bromide] and nucleic acids.
abstract: A polycation, poly[acrylamide-(2-methylacryloxyethyl) dimethyl buthylammonium bromide] [P (AM-DMB)], was synthesized. The interaction between P (AM-DMB) and DNA was studied by spectral methods. Resonance light scattering spectra, FTIR-spectra and UV-spectra were used to study the mechanisms of the interaction. The results indicate that the conformation of the DNA alters during the interaction because the microenvironment of DNA changes. The binding constant K between P (AM-DMB) and DNA is 8.0 × 10(3)  L mol(-1) .
authors.affiliation: Ministry of Education Key Laboratory for the Synthesis and Application of Organic Function Molecules, Hubei University, Wuhan, People's Republic of China. Songgw2008@yahoo.com.cn
authors.forename: Gongwu
authors.initials: G
authors.lastname: Song
authors.forename: Mao
authors.initials: M
authors.lastname: Peng
authors.forename: Qiujun
authors.initials: Q
authors.lastname: Yan
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D000180:Acrylic Resins / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D009696:Nucleic Acids / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D000099166:Polyacrylamides
chemical_list: D000178:Acrylamides; D000180:Acrylic Resins; D001965:Bromides; D009696:Nucleic Acids; D000644:Quaternary Ammonium Compounds; D000099166:Polyacrylamides; C515532:poly(acrylamide-co-2-((methacryloyloxy)ethyl)trimethylammonium chloride); C051470:ammonium bromide