Multiple immune abnormalities in a patient with idiopathic CD4+ T-lymphocytopenia.
Idiopathic CD4+ T-lymphocytopenia (ICL) is a new disease entity characterized by CD4+ T-lymphocyte depletion without evidence of HIV infection. We report a 27-year-old ICL patient with a long history of multiple immune abnormalities. His CD4+ T-lymphocyte count started to decrease after generalized lymphadenopathy of an unknown cause at age 3. He satisfied the criteria for ICL at age 9, and the decreased CD4+ T-lymphocyte count persisted for more than 18 years. This is probably the first childhood-onset ICL case in which the trigger event for the development was known together with the patient's autoimmune background.
Yamada
Yasuaki
Y
Department of Laboratory Medicine, Nagasaki University Hospital, Nagasaki. y-yamada@nagasaki-u.ac.jp
Okada
Masahiko
M
Kamitamari
Akira
A
Moriuchi
Hiroyuki
H
Yanai
Masanori
M
Hano
Osamu
O
Tsukasaki
Kunihiro
K
Tsuruda
Kazuto
K
Hasegawa
Hiroo
H
Yanagihara
Katsunori
K
Kamihira
Shimeru
S
D000328:Adult; D006801:Humans; D007154:Immune System Diseases / Q000150:complications*; D008297:Male; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000175:diagnosis* / Q000276:immunology