Imaging the role of biomechanics in osteoarthritis.
Osteoarthritis is widely believed to result from local mechanical factors acting within the context of systemic susceptibility. This narrative review delineates current understanding of the etiopathogenesis of osteoarthritis and more specifically examines the critical role of biomechanics in disease pathogenesis. There are several ways the mechanical forces across the joint can be measured, including some that rely heavily on imaging methods. These are described and methods to advance the field are proposed.
Hunter
David J
DJ
Division of Research, New England Baptist Hospital, 125 Parker Hill Avenue, Boston, MA 02120, USA. djhunter@caregroup.harvard.edu
Wilson
David R
DR
D001696:Biomechanical Phenomena / Q000502:physiology*; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D011859:Radiography; D016474:Weight-Bearing / Q000502:physiology*