Enhanced resistance of DNA nanostructures to enzymatic digestion.
The ability of nucleases to perform their catalytic functions depends on the sequence and structural features of target DNA substrates. Due to their size and shape, several DNA tetrahedra are resistant to the action of specific and non-specific nucleases. Such enhanced stability is a key requirement for DNA nanostructures to be useful as delivery vehicles.
Keum
Jung-Won
JW
Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA.
Bermudez
Harry
H
D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004262:DNA Restriction Enzymes / Q000378:metabolism*; D003850:Deoxyribonuclease I / Q000378:metabolism; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005090:Exodeoxyribonucleases / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry*; D009690:Nucleic Acid Conformation
D004247:DNA; D005090:Exodeoxyribonucleases; C020133:exodeoxyribonuclease III; D004262:DNA Restriction Enzymes; C027908:endodeoxyribonuclease DdeI; D003850:Deoxyribonuclease I; D015252:Deoxyribonucleases, Type II Site-Specific