APC in cell migration.
Adenomatous Polyposis Coli (APC) is a tumor suppressor protein involved in the initiation and progression of colon cancer. The most widely accepted function ofAPC is to participate to the Wnt signaling pathway, by downregulating beta-catenin and thereby controlling gene transcription and cell proliferation. However, APC is clearly a multifunctional protein whose loss contributes to tumor formation in multiple ways. Regulation of APC localization during cell migration and the ability of APC to bind multiple polarity proteins and microtubule-associated molecules support the idea that APC plays a key role in directed cell migration and that this function may contribute to its tumour suppressor activity.
Etienne-Manneville
Sandrine
S
Institut Pasteur CNRS URA, Paris, France. sandrine.etienne-manneville@pasteur.fr
D000199:Actins / Q000378:metabolism; D025601:Adenomatous Polyposis Coli Protein / Q000502:physiology*; D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D016764:Cell Polarity; D018385:Centrosome / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D008870:Microtubules / Q000378:metabolism
D000199:Actins; D025601:Adenomatous Polyposis Coli Protein