White matter lesions suggestive of amyotrophic lateral sclerosis attributed to celiac disease.
CD is an autoimmune-mediated disorder of the gastrointestinal tract. Initial symptom presentation is variable and can include neurologic manifestations that may comprise ataxia, neuropathy, dizziness, epilepsy, and cortical calcifications rather than gastrointestinal-hindering diagnosis and management. We present a case of a young man with progressive neurologic symptoms and brain MR imaging findings worrisome for ALS. During the diagnostic work-up, endomysium antibodies were discovered, and CD was confirmed by upper gastrointestinal endoscopy with duodenal biopsies. MR imaging findings suggestive of ALS improved after gluten-free diet institution.
Brown
K J
KJ
Department of Radiology, University of North Carolina, Chapel Hill, North Carolina 27599-7510, USA. kelanbrown@gmail.com
Jewells
V
V
Herfarth
H
H
Castillo
M
M
D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000209:etiology* / Q000473:pathology*; D002446:Celiac Disease / Q000150:complications* / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D006801:Humans; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology*