Nicotinamide N-Methyltransferase upregulation correlates with tumour differentiation in oral squamous cell carcinoma.
We investigated expression levels of Nicotinamide N-Methyltransferase (NNMT), an enzyme involved in the biotransformation of many drugs and xenobiotic compounds, in oral squamous cell carcinoma (OSCC). Measurements were performed by immunohistochemistry and the relationship between tumour characteristics and NNMT levels in OSCC was studied to evaluate the effectiveness of NNMT as a prognostic marker in squamous cell carcinoma of the oral cavity. In conclusion, the present study suggests that NNMT may have potential as a biomarker and as a therapeutic target for OSCC.
Emanuelli
Monica
M
Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Ancona, Italy. m.emanuelli@univpm.it
Santarelli
Andrea
A
Sartini
Davide
D
Ciavarella
Domenico
D
Rossi
Valentina
V
Pozzi
Valentina
V
Rubini
Corrado
C
Lo Muzio
Lorenzo
L
D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000473:pathology*; D002454:Cell Differentiation / Q000502:physiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000201:enzymology* / Q000473:pathology*; D050903:Nicotinamide N-Methyltransferase / Q000096:biosynthesis*; D011379:Prognosis; D016610:Tissue Embedding; D016707:Tissue Fixation; D015854:Up-Regulation
D050903:Nicotinamide N-Methyltransferase