Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system.
The present review gives an overview on the serotonin (5-hydroxytryptamine; 5-HT) system, its receptors and their relationship to central nervous system physiology and disorders. Additionally, we also introduce the recent knowledge about the 5-HT receptor ligands in preclinical research, clinical trials and as approved drugs.
Filip
Małgorzata
M
Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Kraków, Poland. filip@if-pan.krakow.pl
Bader
Michael
M
D000818:Animals; D002490:Central Nervous System / Q000502:physiology / Q000503:physiopathology; D002493:Central Nervous System Diseases / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008024:Ligands; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*
D008024:Ligands; D011985:Receptors, Serotonin; D012701:Serotonin