Unraveling the role of high mobility group box protein 1 in severe trauma.
High mobility group box protein 1 (HMGB1) has been shown to participate in acute inflammatory reactions, including acute lung injury and sepsis. There is also evidence that circulating levels of HMGB1 are increased after severe trauma and are associated with clinically important outcome parameters, including mortality. Recent studies demonstrated that HMGB1 itself has little or no proinflammatory activity, but is able to potentiate inflammatory responses through binding to mediators, such as endotoxin or cytokines. Important questions are to determine the binding partners for HMGB1 in the setting of severe injury and whether inhibition of interactions of HMGB1 and associated molecules with the cell surface can affect outcome after trauma.
Abraham
Edward
E
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA. eabraham@uab.edu
D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D004195:Disease Models, Animal; D024243:HMGB1 Protein / Q000097:blood* / Q000276:immunology / Q000502:physiology; D006801:Humans; D007239:Infections / Q000097:blood; D018805:Sepsis / Q000276:immunology; D012720:Severity of Illness Index; D015996:Survival Rate; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000097:blood* / Q000401:mortality / Q000503:physiopathology
D024243:HMGB1 Protein