title: The effect of psychological stress on iron absorption in rats.
abstract: BACKGROUND
  Psychological stress (PS) is recognized as an important pathogenic factor which leads to metabolism disorder in many diseases. Previous studies have shown that systemic iron homeostasis in mammalians was changed under specific stress conditions.
  
  
  METHODS
  In present study, we used communication box to create psychological stress model and investigated the iron apparent absorption, iron accumulation in the apical poles of villous enterocytes and protein expressions of ferroportin 1 (FPN1), ferritin, divalent metal transporter 1 (DMT1).
  
  
  RESULTS
  Our study showed that iron apparent absorption decreased and iron significantly accumulated in the apical poles of villous enterocytes in 3 d and 7 d PS groups. The expression of intestinal FPN1 in 3 d and 7 d PS groups was lower than that of control, while the change of intestinal ferritin was opposite. However, the expression of DMT1 did not change.
  
  
  CONCLUSIONS
  These results demonstrate that PS can decrease iron absorption in rats, which might be related to regulation expression of iron transporters.
authors.affiliation: Department of Military Hygiene, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, PR China. Jianbochen@yahoo.com.cn
authors.forename: Jianbo
authors.initials: J
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
authors.forename: Chengjie
authors.initials: C
authors.lastname: Chen
authors.forename: Wanyin
authors.initials: W
authors.lastname: Wang
authors.forename: Siyu
authors.initials: S
authors.lastname: Yu
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.forename: Min
authors.initials: M
authors.lastname: Li
mesh_terms: D000818:Animals; D015153:Blotting, Western; D027682:Cation Transport Proteins / Q000096:biosynthesis; D004195:Disease Models, Animal; D020895:Enterocytes / Q000378:metabolism; D005293:Ferritins / Q000096:biosynthesis; D007408:Intestinal Absorption / Q000502:physiology*; D007501:Iron / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013315:Stress, Psychological / Q000378:metabolism* / Q000473:pathology; D000098742:Ferroportin; D000099236:Solute Carrier Family 11, Member 2
chemical_list: D027682:Cation Transport Proteins; D005293:Ferritins; D007501:Iron; D000098742:Ferroportin; D000099236:Solute Carrier Family 11, Member 2