Lipid autoreactivity in multiple sclerosis.
Lipids comprise over 70% of the myelin sheath but have been largely underinvestigated as autoantigens in multiple sclerosis (MS). This paper cites evidence for the involvement of lipid autoreactivity in MS and details how self lipid cross-reactivity may also contribute to the development of type 1 diabetes and autoimmune thyroid disorders (both of which have been associated with MS). A further analysis of myelin chemistry suggests several mechanisms by which infection may contribute to etiology and trigger lipid autoreactivity via molecular mimicry. This analysis may aid the development of new therapies for autoimmune diseases.
Blewett
M M
MM
Harvard College, 211 Currier Mail Center, 64 Linnaean Street, Cambridge, MA 02138-1502, United States. mblewett@fas.harvard.edu
D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D006801:Humans; D008055:Lipids / Q000276:immunology*; D018448:Models, Immunological; D009103:Multiple Sclerosis / Q000276:immunology*; D013959:Thyroid Diseases / Q000276:immunology*
D001324:Autoantigens; D008055:Lipids