title: Merging chiral organocatalysts: enantio- and diastereoselective direct vinylogous Mannich reaction of alkylimines.
abstract: An enantio- and diastereoselective direct vinylogous Mannich reaction of alpha,alpha-dicyanoolefins and N-sulfonyl alkylimines has been developed by the catalysis of a new family of bifunctional organocatalysts merging chiral BINOL and 9-amino-9-deoxyepi-cinchona alkaloid skeletons, from which chiral beta-, delta- or gamma-amino compounds could be efficiently derived.
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Xiong
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Jia
authors.forename: Wei
authors.initials: W
authors.lastname: Du
authors.forename: Kun
authors.initials: K
authors.lastname: Jiang
authors.forename: Tian-Yu
authors.initials: TY
authors.lastname: Liu
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Chen
mesh_terms: D000470:Alkaloids / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D007097:Imines / Q000737:chemistry*; D008352:Mannich Bases / Q000737:chemistry*; D008968:Molecular Conformation; D009284:Naphthols / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D000475:Alkenes; C406944:BINOL, naphthol; D007097:Imines; D008352:Mannich Bases; D009284:Naphthols