title: Emerging pathways of non-genomic glucocorticoid (GC) signalling in T cells.
abstract: In the last decade new glucocorticoid (GC)-signalling mechanisms have emerged. The evolving field of non-genomic GC actions was precipitated from two major directions: (i) some rapid/acute clinical GC applications could not be explained based on the relatively slowly appearing genomic GC action and (ii) accumulating evidence came to light about the discrepancy in the apoptosis sensitivity and GR expression of thymocytes and other lymphoid cell types. Herein, we attempt to sample the latest information in the field of non-genomic GC signalling in T cells, and correlate it with results from our laboratory. We discuss some aspects of the regulation of thymocyte apoptosis by GCs, paying special interest to the potential role(s) of mitochondrial GR signalling. The interplay between the T cell receptor (TcR) and glucocorticoid receptor (GR) signalling pathways is described in more detail, focusing on ZAP-70, which is a novel target of rapid GC action.
authors.affiliation: Department of Immunology and Biotechnology, Faculty of Medicine, University of Pecs, Pecs, Hungary. fboldizsar@hotmail.com
authors.forename: Ferenc
authors.initials: F
authors.lastname: Boldizsar
authors.forename: Gergely
authors.initials: G
authors.lastname: Talaber
authors.forename: Mariann
authors.initials: M
authors.lastname: Szabo
authors.forename: Domokos
authors.initials: D
authors.lastname: Bartis
authors.forename: Laszlo
authors.initials: L
authors.lastname: Palinkas
authors.forename: Peter
authors.initials: P
authors.lastname: Nemeth
authors.forename: Timea
authors.initials: T
authors.lastname: Berki
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000276:immunology; D016678:Genome; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000378:metabolism*
chemical_list: D005938:Glucocorticoids; D011948:Receptors, Antigen, T-Cell; D011965:Receptors, Glucocorticoid; D051746:ZAP-70 Protein-Tyrosine Kinase