title: Human genetics illuminates the paths to metabolic disease.
abstract: Metabolic diseases represent a growing threat to world-wide public health. In general, these disorders result from the interaction of heritable factors with environmental influences. Here, I will focus on two important metabolic disorders, namely type 2 diabetes and obesity, and explore the extent to which human molecular genetic research has illuminated our understanding of their underlying pathophysiological mechanisms.
authors.affiliation: University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. so104@medschl.cam.ac.uk
authors.forename: Stephen
authors.initials: S
authors.lastname: O'Rahilly
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D009765:Obesity / Q000235:genetics* / Q000503:physiopathology
chemical_list: D007328:Insulin