title: Significant reduction in bacterial shedding and improvement in milk production in dairy farms after the use of a new inactivated paratuberculosis vaccine in a field trial.
abstract: BACKGROUND
  Paratuberculosis vaccination has been in use in some regions for many decades, but results have not been widely spread. A new Mycobacterium avium subsp. paratuberculosis (MAP) killed vaccine was studied in relationship with its effects on fecal shedding and milk production in four farms while other two were kept as controls submitted to a test and cull scheme.
  
  
  RESULTS
  Fecal detection (n = 1829) and milking records (n = 2413) have been analyzed after two (5 herds) and four (1 herd) years of the beginning of the intervention. Shedder prevalence was reduced by 100% in three of the four vaccinated farms, 68% in the total of vaccinated animals and 46% in the two control farms. Total amount of MAP shed was reduced 77% in the vaccinated farms and 94% in the control farms. Overall milk production increased up to 3.9% after vaccination, while there was no significant difference in production after intervention in the non-vaccinated farms.
  
  
  CONCLUSIONS
  MAP shedding reduction can be quickly accomplished both by vaccination and by testing and culling. However, vaccination appears to be a less expensive and more sustainable strategy since it required one single intervention and was also associated with an increase in milk production.
authors.affiliation: Department of Animal Health, NEIKER-Tecnalia, Berreaga 1 E-48160 Derio, Bizkaia, Spain. rjuste@neiker.net
authors.forename: Ramon A
authors.initials: RA
authors.lastname: Juste
authors.forename: Marta
authors.initials: M
authors.lastname: Alonso-Hearn
authors.forename: Elena
authors.initials: E
authors.lastname: Molina
authors.forename: Marivi
authors.initials: M
authors.lastname: Geijo
authors.forename: Patricia
authors.initials: P
authors.lastname: Vazquez
authors.forename: Iker A
authors.initials: IA
authors.lastname: Sevilla
authors.forename: Joseba M
authors.initials: JM
authors.lastname: Garrido