Finale: the last minutes of Smads.
TGF-beta ligands induce phosphorylation of receptor-activated Smads at both the C-terminal tail and the linker region. Two papers from Massagué and colleagues (Alarcón et al., 2009; Gao et al., 2009) reveal a dual role for this linker phosphorylation, which is required for activation of Smads and for their degradation.
Chen
Ye-Guang
YG
State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Tsinghua University, Beijing 100084, China. ygchen@tsinghua.edu.cn
Wang
Xiao-Fan
XF
D000818:Animals; D051379:Mice; D010766:Phosphorylation; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D051785:Smad Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation
D051785:Smad Proteins; D046988:Proteasome Endopeptidase Complex