Gene expression networks: competing mRNA decay pathways in mammalian cells.
Nonsense-mediated mRNA decay and Staufen1-mediated mRNA decay are mechanistically related pathways that serve distinct purposes. In the present article, we give an overview of each pathway. We describe how a factor that is common to both pathways results in their competition. We also explain how competition between the two pathways contributes to the differentiation of C2C12 myoblasts to multinucleated myotubes.
Maquat
Lynne E
LE
Department of Biochemistry and Biophysics and Center for RNA Biology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA. lynne_maquat@urmc.rochester.edu
Gong
Chenguang
C
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D053263:Gene Regulatory Networks; D006801:Humans; D008957:Models, Genetic; D020871:RNA Stability; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics
D016601:RNA-Binding Proteins; C117884:staufen protein, mammalian