HIV infection is associated with a preferential decline in less-differentiated CD56dim CD16+ NK cells.
HIV-1 infection is characterized by loss of CD56(dim) CD16(+) NK cells and increased terminal differentiation on various lymphocyte subsets. We identified a decrease of CD57(-) and CD57(dim) cells but not of CD57(bright) cells on CD56(dim) CD16(+) NK cells in chronic HIV infection. Increasing CD57 expression was strongly associated with increasing frequencies of killer immunoglobulin-like receptors (KIRs) and granzyme B-expressing cells but decreasing percentages of cells expressing CD27(+), HLA-DR(+), Ki-67(+), and CD107a. Our data indicate that HIV leads to a decline of less-differentiated cells and suggest that CD57 is a useful marker for terminal differentiation on NK cells.
Hong
Henoch S
HS
Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Eberhard
Johanna M
JM
Keudel
Phillip
P
Bollmann
Benjamin A
BA
Ballmaier
Matthias
M
Bhatnagar
Nupur
N
Zielinska-Skowronek
Margot
M
Schmidt
Reinhold E
RE
Meyer-Olson
Dirk
D
D019002:CD56 Antigen / Q000378:metabolism; D018959:CD57 Antigens / Q000378:metabolism*; D002454:Cell Differentiation; D015658:HIV Infections / Q000276:immunology* / Q000503:physiopathology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology / Q000378:metabolism / Q000473:pathology*; D017452:Receptors, IgG / Q000378:metabolism
D019002:CD56 Antigen; D018959:CD57 Antigens; D017452:Receptors, IgG