Phorbaketals A, B, and C, sesterterpenoids with a spiroketal of hydrobenzopyran moiety isolated from the marine sponge Phorbas sp.
Three new sesterterpenoids, phorbaketals A (1), B (2), and C (3) which have a spiroketal of the hydrobenzopyran moiety, were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral and chemical methods. They exhibited moderate cytotoxicity against human colorectal, hepatoma, and lung cancer cell lines. Furthermore, the cultivation of the bacterial fraction from the sponge afforded compound 1.
Rho
Jung-Rae
JR
Department of Oceanography, Kunsan National University, Jeonbuk, 573-701, South Korea. jrrho@kunsan.ac.kr
Hwang
Buyng Su
BS
Sim
Chung Ja
CJ
Joung
Seewon
S
Lee
Hee-Yoon
HY
Kim
Hyeon-Jin
HJ
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D056945:Hep G2 Cells; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D054830:Sesterterpenes; C546752:phorbaketal A; C546753:phorbaketal B