title: EuroPhenome: a repository for high-throughput mouse phenotyping data.
abstract: The broad aim of biomedical science in the postgenomic era is to link genomic and phenotype information to allow deeper understanding of the processes leading from genomic changes to altered phenotype and disease. The EuroPhenome project (http://www.EuroPhenome.org) is a comprehensive resource for raw and annotated high-throughput phenotyping data arising from projects such as EUMODIC. EUMODIC is gathering data from the EMPReSSslim pipeline (http://www.empress.har.mrc.ac.uk/) which is performed on inbred mouse strains and knock-out lines arising from the EUCOMM project. The EuroPhenome interface allows the user to access the data via the phenotype or genotype. It also allows the user to access the data in a variety of ways, including graphical display, statistical analysis and access to the raw data via web services. The raw phenotyping data captured in EuroPhenome is annotated by an annotation pipeline which automatically identifies statistically different mutants from the appropriate baseline and assigns ontology terms for that specific test. Mutant phenotypes can be quickly identified using two EuroPhenome tools: PhenoMap, a graphical representation of statistically relevant phenotypes, and mining for a mutant using ontology terms. To assist with data definition and cross-database comparisons, phenotype data is annotated using combinations of terms from biological ontologies.
authors.affiliation: MRC Harwell, Mammalian Genetics Unit, MRC Harwell, Mary Lyon Centre, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, UK.
authors.forename: Hugh
authors.initials: H
authors.lastname: Morgan
authors.forename: Tim
authors.initials: T
authors.lastname: Beck
authors.forename: Andrew
authors.initials: A
authors.lastname: Blake
authors.forename: Hilary
authors.initials: H
authors.lastname: Gates
authors.forename: Niels
authors.initials: N
authors.lastname: Adams
authors.forename: Guillaume
authors.initials: G
authors.lastname: Debouzy
authors.forename: Sophie
authors.initials: S
authors.lastname: Leblanc
authors.forename: Christoph
authors.initials: C
authors.lastname: Lengger
authors.forename: Holger
authors.initials: H
authors.lastname: Maier
authors.forename: David
authors.initials: D
authors.lastname: Melvin
authors.forename: Hamid
authors.initials: H
authors.lastname: Meziane
authors.forename: Dave
authors.initials: D
authors.lastname: Richardson
authors.forename: Sara
authors.initials: S
authors.lastname: Wells
authors.forename: Jacqui
authors.initials: J
authors.lastname: White
authors.forename: Joe
authors.initials: J
authors.lastname: Wood
authors.forename: Martin Hrabé
authors.initials: MH
authors.lastname: de Angelis
authors.forename: Steve D M
authors.initials: SD
authors.lastname: Brown
authors.forename: John M
authors.initials: JM
authors.lastname: Hancock
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Mallon
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods* / Q000639:trends; D030541:Databases, Genetic; D030562:Databases, Protein; D016247:Information Storage and Retrieval / Q000379:methods; D020407:Internet; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D010641:Phenotype; D011381:Programming Languages; D017434:Protein Structure, Tertiary; D012984:Software