Viral and host proteins involved in picornavirus life cycle.
Picornaviruses cause several diseases, not only in humans but also in various animal hosts. For instance, human enteroviruses can cause hand-foot-and-mouth disease, herpangina, myocarditis, acute flaccid paralysis, acute hemorrhagic conjunctivitis, severe neurological complications, including brainstem encephalitis, meningitis and poliomyelitis, and even death. The interaction between the virus and the host is important for viral replication, virulence and pathogenicity. This article reviews studies of the functions of viral and host factors that are involved in the life cycle of picornavirus. The interactions of viral capsid proteins with host cell receptors is discussed first, and the mechanisms by which the viral and host cell factors are involved in viral replication, viral translation and the switch from translation to RNA replication are then addressed. Understanding how cellular proteins interact with viral RNA or viral proteins, as well as the roles of each in viral infection, will provide insights for the design of novel antiviral agents based on these interactions.
Lin
Jing-Yi
JY
Research Center for Emerging Viral Infections, Chang Gung University, Tao-Yuan, Taiwan. jylin@mail.cgu.edu.tw
Chen
Tzu-Chun
TC
Weng
Kuo-Feng
KF
Chang
Shih-Cheng
SC
Chen
Li-Lien
LL
Shih
Shin-Ru
SR
D000818:Animals; D002213:Capsid / Q000737:chemistry; D016679:Genome, Viral; D006801:Humans; D008954:Models, Biological; D010849:Picornaviridae / Q000235:genetics / Q000502:physiology*; D010850:Picornaviridae Infections / Q000378:metabolism / Q000821:virology*; D014176:Protein Biosynthesis; D034622:RNA Interference; D012367:RNA, Viral / Q000737:chemistry; D014764:Viral Proteins / Q000737:chemistry; D014779:Virus Replication
D012367:RNA, Viral; D014764:Viral Proteins