title: Characteristics of pulmonary tuberculosis in a hyperendemic area: the city of Santos, Brasil.
abstract: OBJECTIVE
  To characterize the profile of patients with pulmonary tuberculosis (PTB) in the city of Santos, Brazil, according to biological, environmental and institutional factors.
  
  
  METHODS
  Descriptive study, using the TB surveillance database, including patients with PTB, aged 15 years or older, residing in the city of Santos and whose treatment was initiated between 2000 and 2004.
  
  
  RESULTS
  We identified 2,176 cases, of which 481 presented a history of TB. Of those 481 patients, 29.3% were cured, and 70.7% abandoned treatment. In 61.6% of the cases, the diagnosis was confirmed by sputum smear microscopy, whereas it was confirmed based on clinical and radiological criteria in 33.8%; 69.0% were male; and 69.5% were between 20 and 49 years of age. There were 732 hospitalizations, and the mean length of hospital stay was 32 days (first hospitalization). The prevalence of alcoholism, diabetes and TB/HIV coinfection was, respectively, 11.7%, 8.2% and 16.2%. The prevalence of TB/HIV coinfection decreased from 20.7% to 12.9% during the study period. The treatment outcome was cure, abandonment, death from TB and death attributed to TB/HIV coinfection in 71.0%, 12.1%, 3.9% and 2.5%, respectively. The directly observed treatment, short-course (DOTS) was adopted in 63.4% of cases, and there were no significant differences between DOTS and the conventional treatment approach in terms of outcomes (p > 0.05). The mean annual incidence of PTB was 127.9/100,000 population (range: 72.8-272.92/100,000 population, varying by region). The mean annual mortality rate for PTB was 6.9/100,000 population.
  
  
  CONCLUSIONS
  In areas hyperendemic for TB, DOTS should be prioritized for groups at greater risk of treatment abandonment or death, and the investigation of TB contacts should be intensified.
authors.affiliation: Department of Epidemiology of the University of São Paulo School of Public Health, São Paulo, Brazil.
authors.forename: Andrea Gobetti Vieira
authors.initials: AG
authors.lastname: Coelho
authors.forename: Liliana Aparecida
authors.initials: LA
authors.lastname: Zamarioli
authors.forename: Carmen Argüello
authors.initials: CA
authors.lastname: Perandones
authors.forename: Ivonete
authors.initials: I
authors.lastname: Cuntiere
authors.forename: Eliseu Alves
authors.initials: EA
authors.lastname: Waldman
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D023801:Directly Observed Therapy / Q000379:methods / Q000706:statistics & numerical data; D019353:Endemic Diseases / Q000706:statistics & numerical data*; D004812:Epidemiologic Methods; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D019233:Retreatment / Q000706:statistics & numerical data; D012959:Socioeconomic Factors; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000453:epidemiology* / Q000628:therapy; D055815:Young Adult