title: Preoperative sensorimotor mapping in brain tumor patients using spontaneous fluctuations in neuronal activity imaged with functional magnetic resonance imaging: initial experience.
abstract: OBJECTIVE
  To describe initial experience with resting-state correlation mapping as a potential aid for presurgical planning of brain tumor resection.
  
  
  METHODS
  Resting-state blood oxygenation-dependent functional magnetic resonance imaging (fMRI) scans were acquired in 17 healthy young adults and 4 patients with brain tumors invading sensorimotor cortex. Conventional fMRI motor mapping (finger-tapping protocol) was also performed in the patients. Intraoperatively, motor hand area was mapped using cortical stimulation.
  
  
  RESULTS
  Robust and consistent delineation of sensorimotor cortex was obtained using the resting-state blood oxygenation-dependent data. Resting-state functional mapping localized sensorimotor areas consistent with cortical stimulation mapping and in all patients performed as well as or better than task-based fMRI.
  
  
  CONCLUSIONS
  Resting-state correlation mapping is a promising tool for reliable functional localization of eloquent cortex. This method compares well with "gold standard" cortical stimulation mapping and offers several advantages compared with conventional motor mapping fMRI.
authors.affiliation: Department of Radiology, Washington University in St. Louis, St. Louis, Missouri 63110, USA. zhangd@npg.wustl.edu
authors.forename: Dongyang
authors.initials: D
authors.lastname: Zhang
authors.forename: James M
authors.initials: JM
authors.lastname: Johnston
authors.forename: Michael D
authors.initials: MD
authors.lastname: Fox
authors.forename: Eric C
authors.initials: EC
authors.lastname: Leuthardt
authors.forename: Robert L
authors.initials: RL
authors.lastname: Grubb
authors.forename: Michael R
authors.initials: MR
authors.lastname: Chicoine
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Smyth
authors.forename: Abraham Z
authors.initials: AZ
authors.lastname: Snyder
authors.forename: Marcus E
authors.initials: ME
authors.lastname: Raichle
authors.forename: Joshua S
authors.initials: JS
authors.lastname: Shimony
mesh_terms: D001931:Brain Mapping / Q000379:methods*; D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D002560:Cerebrovascular Circulation / Q000502:physiology; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005909:Glioblastoma / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D006225:Hand / Q000294:innervation; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D009044:Motor Cortex / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D009068:Movement / Q000502:physiology; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D010291:Paresis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods*; D011597:Psychomotor Performance / Q000502:physiology; D013003:Somatosensory Cortex / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D020886:Somatosensory Disorders / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control