The critical role of the endocannabinoid system in emotional homeostasis: avoiding excess and deficiencies.
The endocannabinoid system is critical in the regulation of emotion and stress responsiveness. Despite the promising therapeutic value of its pharmacological modulation, deficient and excessive endocannabinoid signalling should be avoided. This mini-review will provide an up-to-date revision on this topic, emphasizing the relevance of a normative endocannabinoid system for emotional homeostasis.
Marco
E M
EM
Dept. Physiology (Animal Phisiology II), Faculty of Biology, Complutense University of Madrid, Madrid, Spain.
Viveros
M P
MP
D000818:Animals; D001095:Arachidonic Acids / Q000737:chemistry / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D063386:Cannabinoid Receptor Agonists; D063385:Cannabinoid Receptor Modulators / Q000502:physiology*; D004644:Emotions; D063388:Endocannabinoids; D005989:Glycerides / Q000737:chemistry / Q000494:pharmacology; D006706:Homeostasis; D001523:Mental Disorders / Q000523:psychology; D051379:Mice; D053284:Polyunsaturated Alkamides / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D043884:Receptor, Cannabinoid, CB1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D043882:Receptors, Cannabinoid / Q000378:metabolism; D015398:Signal Transduction
D001095:Arachidonic Acids; D063386:Cannabinoid Receptor Agonists; D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D005989:Glycerides; D053284:Polyunsaturated Alkamides; D043884:Receptor, Cannabinoid, CB1; D043882:Receptors, Cannabinoid; C094503:glyceryl 2-arachidonate; C078814:anandamide