title: A stereoselective approach to nucleosides and 4'-thioanalogues from acyclic precursors.
abstract: D- and L-nucleosides and analogues thereof, including the 4'-thionucleoside series, are one of the most important biological and pharmaceutically active classes of compounds. A novel approach to their synthesis from chiral acyclic thioaminal, bearing the nucleobase, is described.
authors.affiliation: Institut de recherches cliniques de Montréal, Bio-organic Chemistry Laboratory, 110 avenue des Pins Ouest, Montréal, Québec, Canada H2W 1R7.
authors.forename: Daniel
authors.initials: D
authors.lastname: Chapdelaine
authors.forename: Benoit
authors.initials: B
authors.lastname: Cardinal-David
authors.forename: Michel
authors.initials: M
authors.lastname: Prévost
authors.forename: Marc
authors.initials: M
authors.lastname: Gagnon
authors.forename: Isabelle
authors.initials: I
authors.lastname: Thumin
authors.forename: Yvan
authors.initials: Y
authors.lastname: Guindon
mesh_terms: D009705:Nucleosides / Q000737:chemistry*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D009705:Nucleosides; D013438:Sulfhydryl Compounds