title: [A simple method of synthesis of triterpene glycosides similar to glycyrrhizic acid and their hepatoprotective activity in vitro].
abstract: A simplified method of synthesis of triterpene l,2-trans-glycosides was developed using the glycosylation of glycyrrhetic acid (GLA) and 18,19-dehydro-GLA by beta-pyranose peracetates in the presence of SnCl(4) and molecular sieves 4 A. The synthesized glycosides exhibited hepatoprotective activity toward the human hepatoma HepG2 cell line on the model of alcohol hepatitis and decreased the level of TNF-alpha protein.
authors.affiliation: Institute of Organic Chemistry, Ufa Research Center, Russian Academy of Sciences, Ufa, Bashkortostan, Russia.
authors.forename: L R
authors.initials: LR
authors.lastname: Mikhailova
authors.forename: L A
authors.initials: LA
authors.lastname: Baltina
authors.forename: L A
authors.initials: LA
authors.lastname: Baltina
authors.forename: R M
authors.initials: RM
authors.lastname: Kondratenko
authors.forename: S A
authors.initials: SA
authors.lastname: Nepogodiev
authors.forename: R A
authors.initials: RA
authors.lastname: Field
authors.forename: O
authors.initials: O
authors.lastname: Kunert
authors.forename: M Ch
authors.initials: MCh
authors.lastname: Yin
mesh_terms: D045744:Cell Line, Tumor; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D019695:Glycyrrhizic Acid; D006519:Hepatitis, Alcoholic / Q000188:drug therapy*; D022781:Hepatocytes / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008954:Models, Biological; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D006027:Glycosides; D014315:Triterpenes; D014409:Tumor Necrosis Factor-alpha; D019695:Glycyrrhizic Acid