A mild and efficient synthesis of monofluorinated α-lactam pseudopeptides via a novel dehydrofluorination of Ugi products.
Six novel monofluorinated α-lactam pseudopeptide derivatives were synthesized via Ugi reaction using gem-difluoromethylene-containing isocyanide as a key component, followed by dehydrofluorination of Ugi products in one pot without additional base.
Liu
Nianjin
N
Shanghai Key Laboratory of Chemical Biology, Center of Fluorine Chemical Technology, School of Pharmacy, East China University of Science and Technology, 200237, Shanghai, China.
Cao
Song
S
Wu
Jingjing
J
Shen
Li
L
Yu
Jinlong
J
Zhang
Jian
J
Li
Hui
H
Qian
Xuhong
X
D002625:Chemistry, Organic / Q000379:methods*; D054879:Halogenation; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents / Q000737:chemistry
D007769:Lactams; D010455:Peptides; D012997:Solvents