Peculiarities of abzymes from sera and milk of healthy donors and patients with autoimmune and viral diseases.
The detection of catalytic activity of antibodies is the earliest indicator of development of autoimmune diseases (AID). In early stages of AID, the repertoire of abzymes with various properties is relatively small, but it is greatly increased during their development. Catalytic diversity of the abzymes includes DNase, RNase, ATPase, and oxidoreductase activities; there are antibodies phosphorylating proteins, lipids, and polysaccharides. This review summarizes new data on abzyme heterogeneity and possible reasons for this phenomenon. A possible role of abzymes and their exceptional multiplicity in the pathogenesis of different AID is discussed.
Nevinsky
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GA
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, Novosibirsk, 630090, Russia. nevinsky@niboch.nsc.ru
Buneva
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D017151:Antibodies, Catalytic / Q000097:blood* / Q000378:metabolism; D001327:Autoimmune Diseases / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008895:Milk, Human / Q000276:immunology*; D012016:Reference Values; D014777:Virus Diseases / Q000097:blood* / Q000378:metabolism
D017151:Antibodies, Catalytic