title: Locked-in syndrome: A rare manifestation of pediatric stroke.
abstract: Locked-in syndrome is characterized by upper motor neuron quadriplegia, paralysis of lower cranial nerves, bilateral horizontal gaze palsy and anarthria, with preserved consciousness. It is due to a ventral pontine lesion following a basilar artery occlusion. We report the first Indian case report of locked-in syndrome, a 10-year old girl in whom the syndome was preceded by a 'herald hemiparesis'. Although the exact etiology for the basilar artery occlusion could not be determined, treatment with low molecular weight heparin and warfarin was followed by partial recovery.
authors.affiliation: Department of Pediatric, Maulana Azad Medical College and Associated Lok Nayak Hospital, Bahadur Shah Zafar Marg, New Delhi, India.
authors.forename: Monica
authors.initials: M
authors.lastname: Juneja
authors.forename: Rahul
authors.initials: R
authors.lastname: Jain
authors.forename: Swati
authors.initials: S
authors.lastname: Singhal
authors.forename: Devendra
authors.initials: D
authors.lastname: Mishra
authors.forename: Sapna
authors.initials: S
authors.lastname: Singh
mesh_terms: D001157:Arterial Occlusive Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D001488:Basilar Artery / Q000473:pathology*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D007194:India; D018810:Magnetic Resonance Angiography; D009483:Neuropsychological Tests; D011782:Quadriplegia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D035583:Rare Diseases; D020127:Recovery of Function; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D016896:Treatment Outcome; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D006495:Heparin, Low-Molecular-Weight; D014859:Warfarin