title: The effects of exercise-induced fatigue on acetylcholinesterase expression and activity at rat neuromuscular junctions.
abstract: Acetylcholinesterase is the enzyme that terminates neurotransmission by hydrolyzing the acetylcholine released by the motoneurons at the neuromuscular junctions. Although acetylcholinesterase has been studied for almost a century, the underlying relationship between exercise-induced fatigue and acetylcholinesterase activity at the synaptic cleft is not clear. The purpose of this study was to assess the effects of exercise-induced fatigue on the expression and activity of acetylcholinesterase at the neuromuscular junctions. The expression and activity of acetylcholinesterase at the gastrocnemius neuromuscular junctions was decreased transiently by exercise-induced fatigue and then gradually increased over 24 hr. The expression of acetylcholinesterase in the 24 hr recovery group returned to the level of the control (non-exercised) group, but the activity of acetylcholinesterase remained significantly lower. These data suggest that the decrease of acetylcholinesterase expression and activity may be involved in the production and/or maintenance of exercise-induced fatigue.
authors.affiliation: Department of Anatomy & Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Wen
authors.forename: Wang
authors.initials: W
authors.lastname: Hui
authors.forename: Chen
authors.initials: C
authors.lastname: Dan
authors.forename: Wu
authors.initials: W
authors.lastname: Xiao-Qiong
authors.forename: Tong
authors.initials: T
authors.lastname: Jian-Bin
authors.forename: Li
authors.initials: L
authors.lastname: Chang-Qi
authors.forename: Lei
authors.initials: L
authors.lastname: De-Liang
authors.forename: Cai
authors.initials: C
authors.lastname: Wei-Jun
authors.forename: Li
authors.initials: L
authors.lastname: Zhi-Yuan
authors.forename: Luo
authors.initials: L
authors.lastname: Xue-Gang