Secondary metabolites from the liverwort Ptilidium pulcherrimum.
A new trinortriterpenoid, diospyrolide acetate (1) and a new diphenylmethane derivative, pulcherrimumin (12), together with ten known pentacyclic triterpenoids (2-11) and four aromatic compounds (13-16), were isolated from the liverwort Ptilidium pulcherrimum. Their structures were established on the basis of extensive analysis of NMR data and by chemical methods. The cytotoxicity of compounds 1-16 was evaluated against the PC3, MDA-MB-231, and Hela cells lines. Ursane triterpenoids 8-10 exhibited moderate cytotoxicity against PC3 cells with IC50 values ranging from 10.1 to 39.7 microM.
Guo
Dong-Xiao
DX
Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, PR China.
Du
Yu
Y
Wang
Yan-Yan
YY
Sun
Ling-Mei
LM
Qu
Jian-Bo
JB
Wang
Xiao-Ning
XN
Lou
Hong-Xiang
HX
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D035926:Hepatophyta / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D015394:Molecular Structure; D051381:Rats; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes