A randomized, double-blind study examining the comparative efficacies and safety of inhaled epinephrine and nasal decongestant in hospitalized infants with acute bronchiolitis.
Optimal treatment of acute bronchiolitis is currently unclear. In a double-blind study, we found no significant differences between inhaled epinephrine and nasal decongestant in hospitalized infants with acute bronchiolitis regarding length of hospitalization, need for oxygen supplementation, or intravenous fluids and clinical score. Nasal decongestant is as effective as inhaled epinephrine in acute bronchiolitis.
Livni
Gilat
G
Department of Pediatrics A, Schneider Children's Medical Center, Petach Tikva 49202, Israel.
Rachmel
Avinoam
A
Marom
Daphna
D
Yaari
Arnon
A
Tirosh
Naama
N
Ashkenazi
Shai
S
D000280:Administration, Inhalation; D001988:Bronchiolitis / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D004311:Double-Blind Method; D004837:Epinephrine / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005440:Fluid Therapy / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007297:Inpatients; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D014663:Nasal Decongestants / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D010102:Oxygen Inhalation Therapy / Q000706:statistics & numerical data; D012720:Severity of Illness Index
D001993:Bronchodilator Agents; D014663:Nasal Decongestants; D004837:Epinephrine