A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation.
In many eukaryotic mRNAs one or more short 'upstream' open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated by their variety of features in polyamine pathway biosynthetic mRNAs. Their propensity to act as sensors for regulatory circuits and to amplify the signals likely explains their occurrence in most polyamine pathway mRNAs. The uORF-mediated polyamine responsive autoregulatory circuits found in polyamine pathway mRNAs exemplify the translationally regulated dynamic interface between components of the proteome and metabolism.
Ivanov
Ivaylo P
IP
BioSciences Institute, University College Cork, Cork, Ireland and Department of Human Genetics, University of Utah, Salt Lake City, UT 84112-5330, USA.
Atkins
John F
JF
Michael
Antony J
AJ
D000123:Acetyltransferases / Q000235:genetics / Q000378:metabolism; D012437:Adenosylmethionine Decarboxylase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D018965:Frameshifting, Ribosomal; D005786:Gene Expression Regulation; D016366:Open Reading Frames; D011073:Polyamines / Q000378:metabolism*; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D013097:Spermine Synthase / Q000235:genetics / Q000378:metabolism; D000099228:Diamine N-Acetyltransferase
D000123:Acetyltransferases; D012437:Adenosylmethionine Decarboxylase; D002352:Carrier Proteins; D011073:Polyamines; D011506:Proteins; D013097:Spermine Synthase; D000099228:Diamine N-Acetyltransferase; C031017:ornithine decarboxylase antizyme; C039317:ornithine decarboxylase antizyme inhibitor