title: Prognostic predictors and long-term outcome of postoperative irradiation in thymoma: a study of 241 patients.
abstract: The purpose of this study was to identify the prognostic predictors treated with postoperative irradiation in patients with thymoma. Two hundred forty-one patients with histologically confirmed thymoma were collected and retrospectively reviewed in this study. Fifty-four patients had stage I disease; 57, stage II; 120, stage III; 10, stage IV. One hundred sixty patients underwent total thymectomy; 63, partial resection; 18, debulking or biopsy. Patients were irradiated after surgery with median dose of 50 Gy by conventional fractionation. The overall survival rates at 5 and 10 years were 83.1% and 72.6%, respectively. The 10-year overall survival was 87% for stage I, 78.7% for stage II, 57.4% for stage III, and 24.3% for stage IV. The conclusions were drawn from this analysis. For stage I, the role of postoperative irradiation needed further investigation. For stage II-III, surgery and postoperative irradiation should be part of standard care. The favorable prognostic predictors were female, early stage, and surgical extirpation.
authors.affiliation: Department of Radiation Oncology, Fudan University Cancer Hospital, Shanghai, China.
authors.forename: Kai-Liang
authors.initials: KL
authors.lastname: Wu
authors.forename: Jing-Fang
authors.initials: JF
authors.lastname: Mao
authors.forename: Gui-Yuan
authors.initials: GY
authors.lastname: Chen
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Fu
authors.forename: Hao
authors.initials: H
authors.lastname: Qian
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant; D002648:Child; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D018579:Patient Selection; D016016:Proportional Hazards Models; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012737:Sex Factors; D013934:Thymectomy; D013945:Thymoma / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery*; D013953:Thymus Neoplasms / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult