Mathematical model for optimal use of sulfadoxine-pyrimethamine as a temporary malaria vaccine.
In this paper, we introduce a deterministic malaria model for determining the drug administration protocol that leads to the smallest first malaria episodes during the wet season. To explore the effects of administering the malaria drug on different days during the wet season while minimizing the potential harmful effects of drug overdose, we define 40 drug administration protocols. Our results fit well with the clinical studies of Coulibaly et al. at a site in Mali. In addition, we provide protocols that lead to smaller number of first malaria episodes during the wet season than the protocol of Coulibaly et al.
Dembele
Bassidy
B
Department of Mathematics and Computer Science, Grambling State University, Grambling, LA 71245, USA. dem_77@hotmail.com
Friedman
Avner
A
Yakubu
Abdul-Aziz
AA
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage*; D004338:Drug Combinations; D006801:Humans; D008288:Malaria / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control*; D017780:Malaria Vaccines / Q000008:administration & dosage*; D008302:Mali / Q000453:epidemiology; D018448:Models, Immunological; D010961:Plasmodium / Q000276:immunology*; D011739:Pyrimethamine / Q000008:administration & dosage*; D012621:Seasons; D013413:Sulfadoxine / Q000008:administration & dosage*
D000962:Antimalarials; D004338:Drug Combinations; D017780:Malaria Vaccines; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D011739:Pyrimethamine