Lipid profile and non-enzymic antioxidant status in patients with acute coronary syndrome in South India.
OBJECTIVE
Elevated lipid profile and reduced antioxidants accelerate the formation of atherosclerosis. Multiple lines of evidences have suggested that increased lipids and low antioxidants are the major risk factors for the incidence of acute coronary syndrome. Oxidative stress evaluation is now considered as an index for the assessment of development of coronary artery disease. Therefore, we studied association of the levels of non-enzymic antioxidants and lipid profile in controls and patients with acute coronary syndrome (ACS).


RESULTS
The present study was carried out on 485 patients admitted to the emergency care unit, of whom 89 patients were diagnosed as non-cardiac chest pain (NCCP). Total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides were analysed along with non-enzymic antioxidants such as vitamin C, vitamin E, reduced glutathione, MDA and protein thiol in controls and patients with ACS. The levels of total cholesterol and LDL-cholesterol were significantly raised in patients when compared to controls in contrast to lowering of HDL-cholesterol levels in patients than controls. Vitamin C, vitamin E, reduced glutathione, MDA and protein thiol levels were significantly lowered in patients than controls (p<0.05).


CONCLUSIONS
Oxidative stress and lipid profile should be included as important markers in the early detection of acute coronary syndrome.
Gururajan
Priya
P
Department of Biochemistry, Dr KM Cherian Heart Foundation, A Unit of Frontier LifeLine Pvt Ltd, International Centre for Cardiothoracic and Vascular Diseases, R-30 C Ambattur Industrial Estate Road, Mogappair, Chennai 600101, India.
Gurumurthy
Prema
P
Nayar
Pradeep
P
Chockalingam
M
M
Bhuvaneshwari
S
S
Babu
Sai
S
Sarasabharati
A
A
Victor
Dolice
D
Cherian
K M
KM
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology / Q000453:epidemiology; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers; D016022:Case-Control Studies; D002637:Chest Pain; D003324:Coronary Artery Disease / Q000097:blood / Q000201:enzymology / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012307:Risk Factors
D000975:Antioxidants; D015415:Biomarkers; D008055:Lipids