Behavioural deterioration induced by intrahippocampal NAC61-95 injections and attenuation with ibuprofen.
Pre-aggregated non-amyloid component of alpha-synuclein, NAC(61-95), was injected bilaterally into the CA3 area of rat hippocampus and behaviour was assessed using an alternating-lever cyclic-ratio (ALCR) schedule of operant responding. Four groups of rats were used (n=6 per group), subgroups were treated orally with either ibuprofen (40mg/kg) or vehicle (10% sucrose) twice daily. Intrahippocampal injection of NAC(61-95) increased lever switching errors and numbers of activated astrocytes, and ibuprofen treatment alleviated these effects.
O'Hare
Eugene
E
School of Psychology, Queen's University, University Road, Belfast, BT7 1NN, Northern Ireland, UK. e.ohare@qub.ac.uk
Elliott
Jennifer J
JJ
Hobson
Peter
P
Spanswick
David
D
Kim
Eun-Mee
EM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D056654:CA3 Region, Hippocampal / Q000187:drug effects* / Q000473:pathology; D003216:Conditioning, Operant / Q000187:drug effects; D007052:Ibuprofen / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced* / Q000188:drug therapy*; D010446:Peptide Fragments; D051381:Rats; D017207:Rats, Sprague-Dawley; D012055:Reinforcement Schedule; D051844:alpha-Synuclein
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010446:Peptide Fragments; D051844:alpha-Synuclein; C404769:alpha-synuclein (61-95); D007052:Ibuprofen