title: [Establishment of a new rabbit model of ischemic cerebral infarction by autologous clot embolism].
abstract: OBJECTIVE
  To establish a convenient method for preparing rabbit models of ischemic cerebral infarction using autologous clot embolism.
  
  
  METHODS
  Ischemic cerebral infarction was induced in rabbits by embolizing the middle cerebral artery using autologous clot emboli. Clinical and histological observations were carried out to evaluate the validity of the animal model.
  
  
  RESULTS
  Hemiplegia of different severities was observed in the rabbits after the operation. TTC and HE staining of the brain sections confirmed ischemic cerebral infarction 6 h after obstructing the middle cerebral artery with the autologous clot emboli.
  
  
  CONCLUSIONS
  Embolizing the middle cerebral artery using the autologous emboli is convenient to induce focal ischemic cerebral infarction in rabbits. This model has practical value in the study on the mechanism of ischemic cerebrovascular disease and in developing new strategies for prevention and treatment of the relevant diseases in human.
authors.affiliation: Laboratory Animal Center, Xi'an Jiaotong University College of Medicine, Xi'an 710061, China. linyan506@163.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.forename: Pei-Gang
authors.initials: PG
authors.lastname: Yang
authors.forename: Qi
authors.initials: Q
authors.lastname: Yu
authors.forename: Chun-Fang
authors.initials: CF
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.forename: Peng-Hui
authors.initials: PH
authors.lastname: Yang
authors.forename: En-Qi
authors.initials: EQ
authors.lastname: Liu
mesh_terms: D000818:Animals; D002544:Cerebral Infarction / Q000209:etiology; D004195:Disease Models, Animal; D020244:Infarction, Middle Cerebral Artery / Q000209:etiology; D008297:Male; D011817:Rabbits; D011897:Random Allocation