title: Emergence of drug resistance in HIV-1 subtype C infected children failing the South African national antiretroviral roll-out program.
abstract: HIV-1 drug resistance patterns in 41 children failing antiretroviral therapy in South Africa were examined. Resistance mutation profiles were similar to adults published from the region, with the exception of high rates of lopinavir/r resistance (44%). Ninety-eight percent presented with known drug resistance mutations with M184V (82%) and K103N (44%), the dominant mutations.
authors.affiliation: Department of Molecular Medicine and Haematology, Wits Medical School, University of the Witwatersrand, Parktown, South Africa. cwallis@mweb.co.za
authors.forename: Carole L
authors.initials: CL
authors.lastname: Wallis
authors.forename: Linda
authors.initials: L
authors.lastname: Erasmus
authors.forename: Sheba
authors.initials: S
authors.lastname: Varughese
authors.forename: Dalu
authors.initials: D
authors.lastname: Ndiweni
authors.forename: Wendy S
authors.initials: WS
authors.lastname: Stevens
mesh_terms: D044966:Anti-Retroviral Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D024882:Drug Resistance, Viral; D005260:Female; D006078:Government Programs; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D009154:Mutation; D012367:RNA, Viral / Q000097:blood; D013019:South Africa; D017211:Treatment Failure; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics
chemical_list: D044966:Anti-Retroviral Agents; D012367:RNA, Viral; D054302:pol Gene Products, Human Immunodeficiency Virus