title: Gender differences among patients with secondary hyperparathyroidism undergoing parathyroidectomy.
abstract: OBJECTIVE
  Female gender is associated with an increased risk of parathyroid nodular hyperplasia and parathyroidectomy rate in dialysis patients. The purpose of this study was to assess differences between women and men undergoing parathyroidectomy for secondary hyperparathyroidism.
  
  
  METHODS
  We reviewed 121 consecutive patients with end-stage renal disease and advanced secondary hyperparathyroidism who underwent parathyroidectomy between 2004 and 2007. Preoperative characteristics and short-term outcome of these patients were evaluated.
  
  
  RESULTS
  Compared with men (n = 43), women (n = 78) had lower preoperative bone mineral density (both T-scores and Z-scores) as well as lower preoperative hemoglobin levels. The cause of renal failure was also different between the two groups. No differences in preoperative calcium-phosphorus product, alkaline phosphatase, or parathyroid hormone levels were observed. Follow-up analysis showed that biochemical improvement and 1-y recurrence rate was similar between genders.
  
  
  CONCLUSIONS
  Women with secondary hyperparathyroidism had worse bone mineral metabolism before parathyroidectomy. Additional research regarding target organ susceptibility to hyperparathyroidism in different genders is warranted.
authors.affiliation: Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan.
authors.forename: Shih-Ping
authors.initials: SP
authors.lastname: Cheng
authors.forename: Tsen-Long
authors.initials: TL
authors.lastname: Yang
authors.forename: Jie-Jen
authors.initials: JJ
authors.lastname: Lee
authors.forename: Han-Hsiang
authors.initials: HH
authors.lastname: Chen
authors.forename: Chih-Jen
authors.initials: CJ
authors.lastname: Wu
authors.forename: Tsang-Pai
authors.initials: TP
authors.lastname: Liu
authors.forename: Chien-Liang
authors.initials: CL
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015519:Bone Density; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000378:metabolism / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000378:metabolism; D016105:Parathyroidectomy; D011446:Prospective Studies; D012008:Recurrence; D012189:Retrospective Studies; D012727:Sex Characteristics; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D010281:Parathyroid Hormone