Inappropriate sinus tachycardia after hematopoietic stem cell transplantation.
Survivors of childhood cancer and hematopoietic stem cell transplantation are subject to a range of cardiac late effects including conduction abnormalities. We present, the case of a 12-year-old girl diagnosed with inappropriate sinus tachycardia after a history of multiply relapsed acute lymphoblastic leukemia and an exposure history including anthracycline-based chemotherapy followed by the total body irradiation in the context of a hematopoietic stem cell transplant. The clinical importance of this late cardiac effect along with the potential options for therapy is discussed.
Buchbinder
David
D
Department of Pediatric Hematology and Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. dbuchbinder@choc.org
Levi
Daniel S
DS
Ikeda
Alan
A
Shannon
Kevin
K
Moore
Theodore
T
D018943:Anthracyclines / Q000627:therapeutic use; D002648:Child; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000628:therapy; D013616:Tachycardia, Sinus / Q000209:etiology; D014916:Whole-Body Irradiation
D018943:Anthracyclines