Neurofibromatosis with unilateral lower limb gigantism.
The case of a 3-year-old child diagnosed with Type 1 neurofibromatosis is presented, showing pigmented birthmarks and gigantism of the left lower limb associated with the presence of multiple neurofibromas. Increased bone growth appears to be the direct or indirect consequence of a still undefined paracrine effect of nerve tumor cells.
Sabbioni
Giacomo
G
Clinica Ortopedica e Traumatologica I, Laboratorio di Fisopatologia Ortopedica e Medicina Rigenerativa, Istituto Ortopedico Rizzoli, Università di Bologna, Via Pupilli 1, 40136, Bologna, Italy. giacomo.sabbioni@tkd.it
Rani
Nicola
N
Devescovi
Valentina
V
D002675:Child, Preschool; D005877:Gigantism / Q000209:etiology; D006801:Humans; D007866:Leg; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications / Q000175:diagnosis*