title: Diketopiperazines from the Cordyceps-colonizing fungus Epicoccum nigrum.
abstract: New diketopiperazines, epicoccins E-H (1-4) and diphenylalazines A (5) and B (6), have been isolated from the solid-substrate fermentation culture of the Cordyceps-colonizing fungus Epicoccum nigrum. The structures of 1-6 were determined primarily by NMR experiments, and the structure of 1 was confirmed by X-ray crystallography. The absolute configurations of 3 and 5 were assigned using the modified Mosher (3) and Marfey's (5) methods, respectively. Compounds 3-5 showed inhibitory effects on HIV-1 replication in C8166 cells.
authors.affiliation: Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Guo
authors.forename: Bingda
authors.initials: B
authors.lastname: Sun
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Xulin
authors.initials: X
authors.lastname: Chen
authors.forename: Shuchun
authors.initials: S
authors.lastname: Liu
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Yao
authors.forename: Xingzhong
authors.initials: X
authors.lastname: Liu
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032661:Cordyceps / Q000737:chemistry*; D018360:Crystallography, X-Ray; D054659:Diketopiperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018609:Tibet
chemical_list: D019380:Anti-HIV Agents; D054659:Diketopiperazines