title: Synthesis and antitumor activity of novel 2',3'-dideoxy-2',3'-diethanethionucleosides bearing 1,2,3-triazole residues.
abstract: A series of novel 2',3'-dideoxy-2',3'-diethanethioribonucleosides and those modified with a triazole ring were prepared in excellent yields and their antitumor activity was evaluated. Nucleosides with a triazole ring, 16a-16c, showed significantly improved activity towards a broad range of tumor cell lines.
authors.affiliation: School of Chemical Engineering & Environment, Beijing Institute of Technology, Beijing 100081, China.
authors.forename: Jin-Lan
authors.initials: JL
authors.lastname: Yu
authors.forename: Qin-Pei
authors.initials: QP
authors.lastname: Wu
authors.forename: Qing-Shan
authors.initials: QS
authors.lastname: Zhang
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Liu
authors.forename: Yun-Zheng
authors.initials: YZ
authors.lastname: Li
authors.forename: Zi-Ming
authors.initials: ZM
authors.lastname: Zhou
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013872:Thionucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D013872:Thionucleosides; D014230:Triazoles