title: Penicillin and vitamin A as possible therapeutic agents in pityriasis rubra pilaris.
abstract: Pityriasis rubra pilaris (PRP) is a rare skin disorder with versatile clinical presentations. A 62-year-old Caucasian woman with progressive erythroderma and classic adult (type I) PRP is presented. Treatment with systemic steroids and methotrexate produced no improvement. Clinical remission was achieved after systemic therapy with penicillin (both intravenous and intramuscular) and vitamin A. The therapy of PRP is reviewed, focusing on a possible infectious genesis of PRP as well as the role of antibiotics in its management.
authors.affiliation: Department of Dermatology and Venereology, Faculty of Medicine- Sofia, Medical University-Sofia, Bulgaria.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Popova
authors.forename: Razvigor
authors.initials: R
authors.lastname: Darlenski
authors.forename: Nikolai
authors.initials: N
authors.lastname: Tsankov
mesh_terms: D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000975:Antioxidants / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004224:Diterpenes; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D008875:Middle Aged; D010400:Penicillin G / Q000008:administration & dosage*; D010401:Penicillin G Benzathine / Q000008:administration & dosage; D010916:Pityriasis Rubra Pilaris / Q000175:diagnosis / Q000188:drug therapy*; D000084562:Retinyl Esters; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D003692:Delayed-Action Preparations; D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; D010400:Penicillin G; D010401:Penicillin G Benzathine