Systematic investigation of gastrointestinal diseases in China (SILC): validation of survey methodology.
BACKGROUND
Symptom-based surveys suggest that the prevalence of gastrointestinal diseases is lower in China than in Western countries. The aim of this study was to validate a methodology for the epidemiological investigation of gastrointestinal symptoms and endoscopic findings in China.


METHODS
A randomized, stratified, multi-stage sampling methodology was used to select 18,000 adults aged 18-80 years from Shanghai, Beijing, Xi'an, Wuhan and Guangzhou. Participants from Shanghai were invited to provide blood samples and undergo upper gastrointestinal endoscopy. All participants completed Chinese versions of the Reflux Disease Questionnaire (RDQ) and the modified Rome II questionnaire; 20% were also invited to complete the 36-item Short Form Health Survey (SF-36) and Epworth Sleepiness Scale (ESS). The psychometric properties of the questionnaires were evaluated statistically.


RESULTS
The study was completed by 16,091 individuals (response rate: 89.4%), with 3219 (89.4% of those invited) completing the SF-36 and ESS. All 3153 participants in Shanghai provided blood samples and 1030 (32.7%) underwent endoscopy. Cronbach's alpha coefficients were 0.89, 0.89, 0.80 and 0.91, respectively, for the RDQ, modified Rome II questionnaire, ESS and SF-36, supporting internal consistency. Factor analysis supported construct validity of all questionnaire dimensions except SF-36 psychosocial dimensions.


CONCLUSIONS
This population-based study has great potential to characterize the relationship between gastrointestinal symptoms and endoscopic findings in China.
Yan
Xiaoyan
X
Department of Health Statistics, Second Military Medical University, Shanghai, China. xiaoyan1981@gmail.com
Wang
Rui
R
Zhao
Yanfang
Y
Ma
Xiuqiang
X
Fang
Jiqian
J
Yan
Hong
H
Kang
Xiaoping
X
Yin
Ping
P
Hao
Yuantao
Y
Li
Qiang
Q
Dent
John
J
Sung
Joseph
J
Zou
Duowu
D
Johansson
Saga
S
Halling
Katarina
K
Liu
Wenbin
W
He
Jia
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002681:China / Q000453:epidemiology; D003937:Diagnosis, Differential; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods*; D015995:Prevalence; D015203:Reproducibility of Results; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D055815:Young Adult