title: Acute mesenteric and aortic thrombosis associated with antithrombin deficiency: a rare occurrence.
abstract: Antithrombin is a potent inhibitor of the coagulation cascade exerting its primary effects on activated factors X, IX and II. It is the mechanism by which heparin and low-molecular weight heparin cause anti-coagulation. Deficiency of antithrombin presents as a hypercoagulable state, and may result in unexplained deep venous thrombosis, arterial thrombosis and systemic embolization.
authors.affiliation: Department of Cardiothoracic Surgery, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA. domenico-calcaterra@uiowa.edu
authors.forename: Domenico
authors.initials: D
authors.lastname: Calcaterra
authors.forename: Jeremiah T
authors.initials: JT
authors.lastname: Martin
authors.forename: Antoine M
authors.initials: AM
authors.lastname: Ferneini
authors.forename: Ralph W
authors.initials: RW
authors.lastname: De Natale
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage; D000991:Antithrombins / Q000172:deficiency*; D001018:Aortic Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D025861:Blood Coagulation Disorders, Inherited / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D001780:Blood Coagulation Tests; D016913:Blood Component Transfusion; D017548:Echocardiography, Transesophageal; D017128:Embolectomy; D006801:Humans; D008297:Male; D008641:Mesenteric Vascular Occlusion / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D000991:Antithrombins