title: Synthesis of the macrocyclic core of iriomoteolide 3a.
abstract: The asymmetric synthesis of the fully functionalized macrocyclic core of iriomoteolide 3a, a cytotoxic 15-membered macrolide, is disclosed. The key steps involve Sharpless asymmetric dihydroxylation, Sharpless asymmetric epoxidation, olefin cross-metathesis, Yamaguchi esterification, and a ring-closing metathesis reaction for macrocyclization.
authors.affiliation: Organic Division-I, Indian Institute of Chemical Technology, Hyderabad, India 500 007. rajireddy@iict.res.in
authors.forename: Chada Raji
authors.initials: CR
authors.lastname: Reddy
authors.forename: Gajula
authors.initials: G
authors.lastname: Dharmapuri
authors.forename: Nagavaram Narsimha
authors.initials: NN
authors.lastname: Rao
mesh_terms: D003500:Cyclization; D004141:Dinoflagellida / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: C528465:Iriomoteolide-3a; D018942:Macrolides