Erdosteine in renal ischemia-reperfusion injury: an experimental study in pigs.
The aim of the present study was to investigate the effect of erdosteine on renal reperfusion injury. Twelve male Landrace and Yorkshire mixed pigs were randomly divided into two groups: untreated control group (I/R), erdosteine treated group (I/R + erdosteine). Each group is composed of six pigs, and the pigs were unilaterally nephrectomized and their contralateral kidneys were subjected to 30 min of renal pedicle occlusion. The elevations of creatinine and blood urea nitrogen levels were lower in the treated group compared with the control group. The catalase activity and the glutathione peroxidase activity were higher in the erdosteine group. As a result, this study suggests that the erdosteine treatment has a role of attenuation of renal I/R injury recovery of renal function in pig.
Lee
Jae-Yeon
JY
Department of Veterinary Surgery, Research Center for Transgenic Cloned Pigs, Chungnam National University, Daejeon, Korea.
Kim
Hyun-Soo
HS
Park
Chang-Sik
CS
Kim
Myung-Cheol
MC
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D016166:Free Radical Scavengers; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male; D015427:Reperfusion Injury / Q000188:drug therapy / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000473:pathology; D013864:Thioglycolates / Q000627:therapeutic use*; D013876:Thiophenes / Q000627:therapeutic use*
D000975:Antioxidants; D016166:Free Radical Scavengers; D013864:Thioglycolates; D013876:Thiophenes; C048498:erdosteine