title: Superficial acral fibromyxoma: immunohistochemical and ultrastructural analysis of a case, with literature review.
abstract: Superficial acral fibromyxoma (SAFM) is an uncommon tumor of the superficial soft tissues of acral sites. SAFM is a proliferation of fibroblastic cells, within a myxoid to collagenous stroma. The published cases mostly expressed immunoreactivity for CD34, CD99, EMA, and, less frequently, CD10. The authors report an additional case that did not express any of the previously reported markers, including CD34, and antigens of mesenchymal stromal lineage. Ultrastructural study confirmed the tumor cells were typical fibroblasts with cytoplasmic intermediate filaments and numerous cisternae of rough endoplasmic reticulum. The authors describe the first example of SAFM, ultrastructurally studied, with pure fibroblastic immunoprofile.
authors.affiliation: Clinical Pathology, Department of Clinical Radiological and Cytohistopathological Sciences, University of Bologna, Bologna, Italy.
authors.forename: Gianandrea
authors.initials: G
authors.lastname: Pasquinelli
authors.forename: Laura
authors.initials: L
authors.lastname: Foroni
authors.forename: Francesca
authors.initials: F
authors.lastname: Papadopoulos
authors.forename: Leonarda
authors.initials: L
authors.lastname: Dicandia
authors.forename: Michele
authors.initials: M
authors.lastname: Bisceglia
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000378:metabolism; D005350:Fibroma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D045888:Ganglion Cysts / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009260:Nail Diseases / Q000378:metabolism / Q000473:pathology*; D014034:Toes / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm