title: Radiological response and clinical outcome in patients with femoral bone metastases after radiotherapy.
abstract: We evaluated the radiological response and clinical outcome in patients with femoral bone metastases after radiotherapy. 102 consecutive patients with femoral metastases without pathological fracture were treated by surgery or radiotherapy between 2002 and 2005. Twelve of them initially treated with surgery were excluded from this study. The remaining 90 patients with 102 lesions underwent radiation therapy as the initial treatment. Twelve patients who died within 30 days by disease progression and 6 who were lost to follow-up were excluded. The remaining 72 patients with 84 lesions including 43 impending fractures were enrolled in this analysis. Radiological changes were categorized into complete response, partial response, no change, and progressive disease based on plain radiograph findings. Pain relief was reviewed for 77 painful lesions. The median radiation dose was 30 Gy. No re-irradiation was performed. 35 lesions (42%) achieved radiological responses median 3 months after radiotherapy. Pain relief was obtained in 36 of 77 lesions (47%). There was no significant correlation between radiological response and pain relief (P = 0.166). Eleven lesions eventually required surgery and considered as treatment failure. The treatment failure rate in the radiological progressive disease (PD) group (8/19, 42%) was significantly higher than that in the non-PD group (3/65, 5%) (P < 0.001). Among 43 impending fracture lesions, 15 lesions (36%) experienced radiological response and 35 lesions (81%) required no surgical interventions. Our data suggest that radiotherapy can enable metastatic bone healing and avoid surgery in many lesions. However, radiological PD lesions often require surgery after radiotherapy.
authors.affiliation: Division of Radiation Oncology, Shizuoka Cancer Center, Shizuoka, Japan. h.harada@scchr.jp
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Harada
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Katagiri
authors.forename: Minoru
authors.initials: M
authors.lastname: Kamata
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yoshioka
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Asakura
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Furutani
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Takahashi
authors.forename: Harumi
authors.initials: H
authors.lastname: Sakahara
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nishimura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D002277:Carcinoma / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D003131:Combined Modality Therapy; D004164:Diphosphonates / Q000627:therapeutic use; D018450:Disease Progression; D019583:Dose Fractionation, Radiation; D005260:Female; D005269:Femur / Q000473:pathology / Q000528:radiation effects*; D005500:Follow-Up Studies; D005598:Fractures, Spontaneous / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D010014:Osteolysis / Q000209:etiology / Q000532:radiotherapy; D010146:Pain / Q000209:etiology; D010166:Palliative Care; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D004164:Diphosphonates