[The influence of paracetamol on the parameters of connective tissue metabolism during experimental osteoarthrosis].
We present results of the biochemical investigation of changes in the metabolism and accumulation of articular cartilage matrix macromolecules and the inflammatory tests in experimental animals with corticosteroidal dystrophy of connective tissues after the therapy by paracetamol in low doses, which corresponded to a standard mean therapeutic dose MTD= 40 mg/kg, 1/2 MTD = 20 mg/kg, 1/4 MTD = 10 mg/kg, and 1/8 MTD = 5 mg/kg, in comparison to the effect of glucosamine hydrochloride treatment in a dose of 50 mg/kg. It is established that paracetamol in low doses exhibits a moderate chondroprotective effect and stimulates the articular cartilage reparative regeneration under conditions of corticostereoidal dystrophy of connective tissues. The most pronounced chondroprotective effect of paracetamol was observed in doses of 1/4 MTD and 1/8 MTD (10 and 5 mg/kg, respectively), but not in the case of MTD. At the same time, the antiinflammatory properties of paracetamol in all doses were insufficiently pronounced.
Tuliakov
V A
VA
Zupanets
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IA
D000082:Acetaminophen / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D002358:Cartilage, Articular / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D005944:Glucosamine / Q000494:pharmacology; D008297:Male; D010003:Osteoarthritis / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects*
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D005944:Glucosamine