Bioactive azafluorenone alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep.
This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of beta-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 microg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.
Prachayasittikul
Supaluk
S
Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand.
Manam
Patumporn
P
Chinworrungsee
Maneekarn
M
Isarankura-Na-Ayudhya
Chartchalerm
C
Ruchirawat
Somsak
S
Prachayasittikul
Virapong
V
D000470:Alkaloids / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology; D000962:Antimalarials / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D044950:Flavanones / Q000737:chemistry; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects; D031044:Polyalthia / Q000737:chemistry*; D011728:Pyridones / Q000737:chemistry; D012855:Sitosterols / Q000737:chemistry; D013265:Stigmasterol / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry
D000470:Alkaloids; D000890:Anti-Infective Agents; D000962:Antimalarials; D044950:Flavanones; D010936:Plant Extracts; D011728:Pyridones; D012855:Sitosterols; D014315:Triterpenes; C054955:onychine; C025473:gamma-sitosterol; D013265:Stigmasterol