Modeling of plasmonic heating from individual gold nanoshells for near-infrared laser-induced thermal therapy.
Gold nanoparticles can be engineered to target cancerous cells and at the same time designed to absorb specific wavelengths of light. Consequently, with the presence of optically tunable gold nanoparticles such as gold nanoshells, light can be effectively converted to heat via photothermal effect well enough to raise the temperature of medium surrounding gold nanoshells for thermal ablation or hyperthermia treatments of cancers. In this study, the authors proposed a new computational method to estimate thermal response of gold nanoshells embedded in a tissue-like medium when illuminated by a near-infrared (NIR) laser. Specifically, the light transport theory with diffusion approximation was initially applied to model the temperature rise within a medium without gold nanoshells as a result of the dissipation of the NIR laser power throughout the medium. After then, the heat generated by individual gold nanoshells due to photothermal effect was calculated and combined with the results for the medium without gold nanoshells to estimate the global elevation of temperature within the gold nanoshell-laden medium. The current computational model was tested for its validity using two different phantom examples, one of which was similar to a previously reported phantom experiment. The test demonstrated the capability of the current model in terms of producing qualitatively reasonable results, while it also revealed a number of potential differences in the assumptions for the current model and previous experiment. After an adjustment in the model parameters to properly take into account such differences, the computational results and the experimental data matched reasonably well within the average percentage difference of 10%.
Cheong
Seong-Kyun
SK
Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
Krishnan
Sunil
S
Cho
Sang Hyun
SH
D000818:Animals; D001831:Body Temperature / Q000502:physiology* / Q000528:radiation effects*; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D006046:Gold / Q000737:chemistry* / Q000528:radiation effects / Q000627:therapeutic use*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D028022:Low-Level Light Therapy / Q000379:methods*; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry* / Q000528:radiation effects / Q000627:therapeutic use*; D011829:Radiation Dosage; D020349:Surface Plasmon Resonance / Q000379:methods*; D013813:Therapy, Computer-Assisted / Q000379:methods
D006046:Gold