Association of malnutrition with amebiasis.
Observation of a cohort of preschool children in Dhaka, Bangladesh, is beginning to reveal the contributions of environment, host, and parasite to amebiasis. Reviewed here are the associations and interactions of malnutrition, IgA and interferon-gamma, human leukocyte antigen alleles, and parasite genotypes to the outcome of infection. Future efforts aimed at understanding the mechanisms of these effects are described.
Petri
William A
WA
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA. wap3g@virginia.edu
Mondal
Dinesh
D
Peterson
Kristine M
KM
Duggal
Priya
P
Haque
Rashidul
R
D000483:Alleles; D000818:Animals; D001459:Bangladesh; D015362:Child Nutrition Disorders / Q000276:immunology* / Q000469:parasitology*; D002675:Child, Preschool; D004404:Dysentery, Amebic / Q000150:complications* / Q000276:immunology; D004748:Entamoeba histolytica / Q000235:genetics / Q000472:pathogenicity*; D004749:Entamoebiasis / Q000150:complications / Q000276:immunology; D005838:Genotype; D006790:Host-Parasite Interactions; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007371:Interferon-gamma / Q000097:blood
D007070:Immunoglobulin A; D007371:Interferon-gamma