title: Type 2 diabetes mellitus is characterized by reduced postprandial adiponectin response: a possible link with diabetic postprandial dyslipidemia.
abstract: We investigated postprandial plasma and adipose tissue (AT) adiponectin changes in relation to obesity and type 2 diabetes mellitus. Fasting and 6 hours after a standard fat-rich meal blood samples (adiponectin, glucose, insulin, lipids) and needle biopsies of abdominal subcutaneous AT (adiponectin messenger RNA, lipoprotein lipase activity) were taken in 10 obese diabetic (OD), 11 obese nondiabetic (OND), and 11 normal-weight control (C) men. The OD and OND subjects had similar adiposity (body mass index, waist circumference) and insulin resistance (hyperinsulinemic euglycemic clamp). Fasting plasma adiponectin and AT gene expression were not significantly different between groups. After meal, plasma adiponectin decreased in OD but significantly increased in OND and C, the changes being significantly different between groups (analysis of variance, P = .01); adiponectin messenger RNA decreased in OD (-0.27 +/- 0.25 AU, P = .01) but was unchanged in OND (P = .59) and C (P = .45). After meal, plasma adiponectin correlated inversely with triglyceride and cholesterol concentrations in chylomicrons and large very low-density lipoprotein, and directly with AT lipoprotein lipase activity (P < .05 for all). Type 2 diabetes mellitus is associated with lower postprandial plasma levels and AT gene expression of adiponectin independently of degree of adiposity and whole-body insulin sensitivity. In patients with diabetes, this may exacerbate postprandial abnormalities of lipoprotein metabolism.
authors.affiliation: Department of Clinical and Experimental Medicine, Federico II University, 80131 Naples, Italy. annuzzi@unina.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Annuzzi
authors.forename: Lutgarda
authors.initials: L
authors.lastname: Bozzetto
authors.forename: Lidia
authors.initials: L
authors.lastname: Patti
authors.forename: Carmela
authors.initials: C
authors.lastname: Santangelo
authors.forename: Rosalba
authors.initials: R
authors.lastname: Giacco
authors.forename: Lucrezia
authors.initials: L
authors.lastname: Di Marino
authors.forename: Claudia
authors.initials: C
authors.lastname: De Natale
authors.forename: Roberta
authors.initials: R
authors.lastname: Masella
authors.forename: Gabriele
authors.initials: G
authors.lastname: Riccardi
authors.forename: Angela A
authors.initials: AA
authors.lastname: Rivellese
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D050171:Dyslipidemias / Q000209:etiology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D008071:Lipoprotein Lipase