title: Impact of first trimester and postpartum period thyroid autoantibodies on abortus incidence in Turkish pregnant women.
abstract: OBJECTIVE
  Abortus is a common problem and is observed approximately in one third of all pregnancies. In this study, we aimed to evaluate in euthyroid pregnant population the effect of thyroid autoantibodies of both first trimester and postpartum period on abortus incidence.
  
  
  METHODS
  Euthyroid 128 pregnant women were included in the study. All pregnants were required having a history of maximum one abortus without any previous endocrinological, immunological disorders. Thyroid autoimmunity was defined as having serum levels of either antithyroidperoxidase or antithyroglobulin antibodies higher than 34 and 115 IU/ml, respectively.
  
  
  CONCLUSIONS
  One hundred of 128 pregnant women (78.1%) had no thyroid autoantibodies, whereas 28 pregnant women (21.9%) had positivity for one of thyroid autoantibodies. One hundred pregnant women (78.1%) gave healthy births, whereas 28 (21.9%) had abortus. Abortus incidence was 28.6% in autoantibody positive group, whereas it was 20% in autoantibody negative group. Serum anti-Tg levels both in first trimester and both in postpartum period were higher in pregnants abortus group when compared with healthy births group. Although, we found no correlation between abortus incidence and thyroid autoantibodies presence, first trimester serum levels of anti-Tg levels may have correlated with abortus incidence and may be an indicator of a closer follow-up. In sight of this study, it can be concluded that autoimmunity against thyroid may continue after termination of pregnancy and this was the first study evaluating the postpartum antibodies levels which may be helpful in subsequent pregnancies.
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Mersin University, Mersin, Turkey. keremsezer@mersin.edu.tr
authors.forename: Kerem
authors.initials: K
authors.lastname: Sezer
authors.forename: Nuri
authors.initials: N
authors.lastname: Kamel
authors.forename: Cihat
authors.initials: C
authors.lastname: Unlu
authors.forename: Hatice Kansu
authors.initials: HK
authors.lastname: Celik
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000276:immunology*; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D015994:Incidence; D049590:Postpartum Period / Q000097:blood / Q000276:immunology; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood / Q000276:immunology; D013959:Thyroid Diseases / Q000150:complications; D013961:Thyroid Gland / Q000276:immunology*; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D001323:Autoantibodies