title: [Drug-induced hypersensitivity syndrome and HHV-6 reactivation].
abstract: Drug-induced hypersensitivity syndrome (DIHS) is an adverse reaction with clinical signs of fever, rash, and internal organ involvement. The culprit drugs of DIHS are limited to several drugs such as carbamazepine, phenytoin, phenobarbital, zonisamide, allopurinol, salazosulfapyridine, diaphenylsulphone, and mexiletine. The association of HHV-6 reactivation with DIHS has been known. Flaring of symptoms such as fever and hepatitis is closely related to HHV-6 reactivation. A combination of immunologic reaction to a drug and HHV-6 reactivation results in the severe course of DIHS.
authors.affiliation: Department of Dermatology, Ehime University Graduate School of Medicine. tohm@m.ehime-u.ac.jp
authors.forename: Mikiko
authors.initials: M
authors.lastname: Tohyama
authors.forename: Koji
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood; D004279:DNA, Viral / Q000097:blood; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000821:virology*; D005260:Female; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D014775:Virus Activation; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G