Supramolecular phospholipids-polyphenolics interactions: the PHYTOSOME strategy to improve the bioavailability of phytochemicals.
The poor and/or erratic oral bioavailability of polyphenolics can be improved using the PHYTOSOME delivery system, a strategy that enhances the rate and the extent of solubilization into aqueous intestinal fluids and the capacity to cross biomembranes. Phospholipids show affinity for polyphenolics, and form supramolecular adducts having a definite stoichiometry. This article reviews the preparation and characterization of PHYTOSOME complexes and their activity in various medicinal (cardiovascular, anti-inflammatory, hepatoprotective, anticancer) and cosmetic (skin aging) realms of application.
Semalty
Ajay
A
Department of Pharmaceutical Sciences, HNB Garhwal University Srinagar, Garhwal, India. semaltyajay@gmail.com
Semalty
Mona
M
Rawat
Mohan Singh Maniyari
MS
Franceschi
Federico
F
D001682:Biological Availability; D001692:Biological Transport; D002318:Cardiovascular Diseases / Q000188:drug therapy; D003358:Cosmetics; D005419:Flavonoids / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D007422:Intestines; D008081:Liposomes / Q000138:chemical synthesis*; D008107:Liver Diseases / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy; D010636:Phenols / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010743:Phospholipids / Q000737:chemistry; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000493:pharmacokinetics* / Q000627:therapeutic use; D059808:Polyphenols; D012995:Solubility
D003358:Cosmetics; D005419:Flavonoids; D008081:Liposomes; D010636:Phenols; D010743:Phospholipids; D010936:Plant Extracts; D059808:Polyphenols