title: 2-aryl-3-(1H-azol-1-yl)-1H-indole derivatives: a new class of antimycobacterial compounds - conventional heating in comparison with MW-assisted synthesis.
abstract: 2-Aryl-3-(1H-imidazol-1-yl and 1H-1,2,4-triazol-1-yl)-1H-indole derivatives were synthesized and tested for their in-vitro antifungal and antimycobacterial activities. These indole derivatives were devoid of antifungal activity against the tested strains of Candida spp. Yet, they exhibited an interesting antitubercular activity against Mycobacterium tuberculosis reference strain H(37)Rv.
authors.affiliation: Department of Pharmaceutical Sciences, University of Trieste, Trieste, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Zampieri
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Mamolo
authors.forename: Erik
authors.initials: E
authors.lastname: Laurini
authors.forename: Giuditta
authors.initials: G
authors.lastname: Scialino
authors.forename: Elena
authors.initials: E
authors.lastname: Banfi
authors.forename: Luciano
authors.initials: L
authors.lastname: Vio
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007211:Indoles