Effective desensitization to imiglucerase in a patient with type I Gaucher disease.
We describe a child who had anaphylactic hypersensitivity to imiglucerase therapy for Gaucher disease. Treatment was stopped and symptoms returned. After immune desensitization to imiglucerase using a rush protocol, the patient was able to resume treatment and has not had further hypersensitivity complications to date.
Peroni
Diego G
DG
Department of Pediatrics, University of Verona, Verona, Italy. peroni.diego@tiscalinet.it
Pescollderungg
Lydia
L
Piacentini
Giorgio L
GL
Cassar
Walburga
W
Boner
Attilio L
AL
D000707:Anaphylaxis / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy*; D002648:Child; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D005776:Gaucher Disease / Q000188:drug therapy* / Q000276:immunology; D005962:Glucosylceramidase / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008297:Male
D005962:Glucosylceramidase; C090568:imiglucerase