title: Microwave-assisted synthesis of 2'-O-aryluridine derivatives.
abstract: A new method for the synthesis of 2'-O-aryluridines was developed via the microwave-mediated reaction of 2,2'-anhydrouridine with aromatic alcohols. Aminophenol and aminonaphthol derivatives underwent selective 2'-O-arylation with 2,2'-anhydrouridine to produce 2'-O-(aminoaryl)uridine derivatives. These reactions proved to proceed without the need for any bases or solvents, but better results were obtained by use of N,N-dimethylacetamide (DMA) as the solvent in some cases.
authors.affiliation: Department of Life Science, Tokyo Institute of Technology, J2-12, 4259 Nagatsuta, Midoriku, Yokohama 226-8501, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Oeda
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Iijima
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Taguchi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ohkubo
authors.forename: Khoji
authors.initials: K
authors.lastname: Seio
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Sekine
mesh_terms: D000438:Alcohols / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D008872:Microwaves; D015394:Molecular Structure; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000438:Alcohols; D014529:Uridine