Zonisamide-induced weight loss in schizophrenia: case series.
Weight gain and metabolic disturbances constitute bothersome problems in schizophrenic patients treated with atypical antipsychotics. Several medications, exercise regimens, and lifestyle changes have been used in attempts to ameliorate these problems. We describe 3 patients with schizophrenia who manifested distinct weight loss and reduction in waist circumference during medication with zonisamide. This report suggests that zonisamide might be associated with weight loss in patients with schizophrenia.
Yang
Jaewon
J
Department of Psychiatry, Korea University College of Medicine, Korea University Research Institute of Mental Health, Seoul, South Korea.
Lee
Moon-Soo
MS
Joe
Sook-Haeng
SH
Jung
In-Kwa
IK
Kim
Seung-Hyun
SH
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D003024:Clozapine / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy*; D015430:Weight Gain / Q000187:drug effects; D015431:Weight Loss / Q000187:drug effects*; D000078305:Zonisamide
D014150:Antipsychotic Agents; D007555:Isoxazoles; D000078305:Zonisamide; D003024:Clozapine