[Correlation analysis between multi-slice CT perfusion imaging and microvessel density in ovarian tumors].
OBJECTIVE
To analyze the correlation between the perfusion data and microvessel density (MVD) in ovarian tumors, and investigate the hemodynamic features of the tumors in terms of anatomy and functional CT imaging.


METHODS
Six patients with surgically confirmed benign ovarian tumors and 6 with malignant ovarian tumors underwent multi-slice CT perfusion imaging to acquire the perfusion parameters including perfusion, PEI, TTP, BV peak enhancement image(PEI), time to peak(TTP) and blood volume(BV). The tumors were stained and counted by Immunohistochemical staining of the microvessels in the tumor was performed to detect the MVD.


RESULTS
s The time-density curves of the benign ovarian tumors increased slowly, reaching the peak at 40 s; the curves of the malignant tumors rose rapidly and continuously and reached the peak at 25 s. The differences in the perfusion data (PEI, TTP, BV) were statistically significant between the benign and malignant tumors (P<0.05). The MVD of the malignant tumors was significantly greater than that of the benign tumors (P<0.05). The mean BV of the malignant ovarian tumor was positively correlated to MVD (r=0.786, P<0.05).


CONCLUSIONS
Multi-slice spiral CT perfusion imaging can provide accurate enhancement data of the ovarian tumors and helps in the diagnosis and differential diagnosis of the ovarian tumors by presenting the changes of the hemodynamic features in the tumors.
Jiang
Gui-Hua
GH
Department of Imaging Diagnosis, Second People's Hospital of Guangdong Province, Guangzhou 510317, China. jiangguihua177@163.com
Zeng
Shao-Qing
SQ
Tian
Jun-Zhang
JZ
Lin
Chu-Lan
CL
Zhang
Lan-Ying
LY
Zhong
Bi-Ling
BL
Liang
Lian-Bao
LB
D000328:Adult; D000368:Aged; D002196:Capillaries / Q000473:pathology; D003536:Cystadenocarcinoma / Q000098:blood supply / Q000000981:diagnostic imaging; D005260:Female; D005350:Fibroma / Q000098:blood supply / Q000000981:diagnostic imaging; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging*; D036542:Tomography, Spiral Computed / Q000379:methods*