title: HIV infection is associated with a preferential decline in less-differentiated CD56dim CD16+ NK cells.
abstract: HIV-1 infection is characterized by loss of CD56(dim) CD16(+) NK cells and increased terminal differentiation on various lymphocyte subsets. We identified a decrease of CD57(-) and CD57(dim) cells but not of CD57(bright) cells on CD56(dim) CD16(+) NK cells in chronic HIV infection. Increasing CD57 expression was strongly associated with increasing frequencies of killer immunoglobulin-like receptors (KIRs) and granzyme B-expressing cells but decreasing percentages of cells expressing CD27(+), HLA-DR(+), Ki-67(+), and CD107a. Our data indicate that HIV leads to a decline of less-differentiated cells and suggest that CD57 is a useful marker for terminal differentiation on NK cells.
authors.affiliation: Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Henoch S
authors.initials: HS
authors.lastname: Hong
authors.forename: Johanna M
authors.initials: JM
authors.lastname: Eberhard
authors.forename: Phillip
authors.initials: P
authors.lastname: Keudel
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Bollmann
authors.forename: Matthias
authors.initials: M
authors.lastname: Ballmaier
authors.forename: Nupur
authors.initials: N
authors.lastname: Bhatnagar
authors.forename: Margot
authors.initials: M
authors.lastname: Zielinska-Skowronek
authors.forename: Reinhold E
authors.initials: RE
authors.lastname: Schmidt
authors.forename: Dirk
authors.initials: D
authors.lastname: Meyer-Olson
mesh_terms: D019002:CD56 Antigen / Q000378:metabolism; D018959:CD57 Antigens / Q000378:metabolism*; D002454:Cell Differentiation; D015658:HIV Infections / Q000276:immunology* / Q000503:physiopathology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology / Q000378:metabolism / Q000473:pathology*; D017452:Receptors, IgG / Q000378:metabolism
chemical_list: D019002:CD56 Antigen; D018959:CD57 Antigens; D017452:Receptors, IgG