title: Retinal function in patients treated with tamoxifen.
abstract: Tamoxifen, an effective treatment of breast cancer, has been shown to cause ocular toxic effects. The purpose of this study was to determine retinal toxicity by full-field and focal electroretinograms (ERGs) in patients treated with tamoxifen. Fullfield and focal ERGs were obtained from three groups: Tamoxifen-14 females (47-72 years, mean 58.3 + or - 9.1) with normal fundus, treated with tamoxifen from 2 to 37 months; No Treatment-10 females (39-65 years, mean 50.1 + or - 8.7) with previous breast cancer diagnosis and before tamoxifen treatment; Control-13 normal female volunteers (41-81 years, mean 52.7 + or - 12.1). Peak-to-peak amplitude and b-wave implicit time were measured and statistically analyzed.Mean peak-to-peak amplitudes and implicit time from full-field and focal ERGs were comparable for the three different groups. Low-dosage tamoxifen showed no retinotoxic effect assessed by full-field and focal ERG in this small group of women with breast cancer.
authors.affiliation: Deptartment of Ophthalmology, Federal University of São Paulo, UNIFESP, São Paulo, Brazil. sesong@oftalmo.epm.br
authors.forename: Sung Eun Song
authors.initials: SE
authors.lastname: Watanabe
authors.forename: Adriana
authors.initials: A
authors.lastname: Berezovsky
authors.forename: Márcia
authors.initials: M
authors.lastname: Motono
authors.forename: Paula Yuri
authors.initials: PY
authors.lastname: Sacai
authors.forename: Josenilson Martins
authors.initials: JM
authors.lastname: Pereira
authors.forename: Juliana Maria Ferraz
authors.initials: JM
authors.lastname: Sallum
authors.forename: Luiz Henrique
authors.initials: LH
authors.lastname: Gebrim
authors.forename: Solange Rios
authors.initials: SR
authors.lastname: Salomão
mesh_terms: D000328:Adult; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000503:physiopathology; D004596:Electroretinography; D005128:Eye Diseases / Q000139:chemically induced; D005260:Female; D006801:Humans; D008875:Middle Aged; D012160:Retina / Q000187:drug effects* / Q000503:physiopathology; D012189:Retrospective Studies; D013629:Tamoxifen / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen