Successful resolution of severe hepatopulmonary syndrome following liver transplantation.
Hepatopulmonary syndrome (HPS) is a complication of portal hypertension, defined by the presence of liver disease, abnormal pulmonary gas exchange and evidence of intrapulmonary vascular dilatations producing a right-to-left intrapulmonary shunt. Liver transplantation (LT) is the treatment of choice; however, severe hypoxemia (PaO(2) < 50 mmHg on room air) is considered a contraindication to LT. This approach disadvantages some patients, particularly young patients with no intrinsic cardio-respiratory disease. We discuss one such patient who improved with LT despite having extremely severe HPS (PaO2 < 29 mmHg).
Asthana
Sonal
S
Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Maguire
Connor
C
Lou
Lawrence
L
Meier
Michael
M
Bain
Vincent
V
Townsend
Derek R
DR
Townsend
Rex
R
Lien
Dale
D
Bigam
David
D
Kneteman
Norman
N
Shapiro
Andrew Mark James
AM
D000022:Abortion, Spontaneous; D000293:Adolescent; D005260:Female; D006085:Graft Survival; D020065:Hepatopulmonary Syndrome / Q000628:therapy*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000628:therapy; D000860:Hypoxia; D016031:Liver Transplantation / Q000379:methods*; D010100:Oxygen / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications; D011312:Pressure; D011659:Pulmonary Gas Exchange; D016896:Treatment Outcome
D010100:Oxygen