Antineoplastic activities of protein-conjugated silver sulfide nano-crystals with different shapes.
In this paper, antineoplastic activities of protein-conjugated silver sulfide nano-crystals with different shapes were described in detail. Transmission electron microscope analysis demonstrated that stable and well-disperse protein-conjugated silver sulfide nano-particles, nano-rods, and nano-wires could be prepared by aqueous chemistry method. The Fourier transform infrared spectrograph analysis indicated the strong coordination between silver sulfide surfaces and -OH and -NH groups in bovine serum albumin. The antineoplastic activities of protein-conjugated silver sulfide nano-crystals were examined by cell viability analysis, optical and electron microscopy methods. The results showed that nano-particles, nano-rods and nano-wires could inhibit the proliferations of human hepatocellular carcinoma Bel-7402 cells and C6 glioma cells, and the activities were size-dependent.
Wang
Hua-Jie
HJ
College of Chemistry and Environmental Science, Henan Normal University, Xinxiang, China.
Yang
Lin
L
Yang
Hua-Yan
HY
Wang
Kui
K
Yao
Wen-Guang
WG
Jiang
Kai
K
Huang
Xiao-Lan
XL
Zheng
Zhi
Z
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000473:pathology*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D018030:Silver Compounds / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D018030:Silver Compounds; D012710:Serum Albumin, Bovine; C013251:silver sulfide