title: Developmental ECM sculpting: laying it down and cutting it up.
abstract: In mammals, proteolytic remodeling of the embryonic extracellular matrix (ECM) controls morphogenesis, but the key players remain elusive. Two recent reports identify new roles for metalloproteinases belonging to the MT-MMP and ADAMTS families in branching morphogenesis and interdigital web regression.
authors.affiliation: Division of Molecular Medicine and Genetics, Department of Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Tamar
authors.initials: T
authors.lastname: Feinberg
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Weiss
mesh_terms: D051722:ADAM Proteins / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D019521:Body Patterning; D005109:Extracellular Matrix / Q000378:metabolism*; D005121:Extremities / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D053675:Versicans / Q000378:metabolism
chemical_list: D053675:Versicans; D051722:ADAM Proteins