title: Enhancement of percutaneous absorption of finasteride by cosolvents, cosurfactant and surfactants.
abstract: The enhancing effects of routinely used co-solvents, propylene glycol and 2-propanol, anionic and cationic surfactants and a co-surfactant with different concentrations were evaluated on the skin permeation of Finasteride. In vitro permeation experiments with rat skin revealed that the solvent mixture is a very important factor in the penetration of Finasteride through the skin. Unexpectedly, cationic and anionic surfactants in various concentrations did not show any enhancement effect on drug transdermal absorption but co-surfactant Transcutol P increased skin penetration of Finastride significantly. Transcutol P with 0.25% and 1% showed the best enhancement in the initial and final sampling time, respectively. Transcutol P in a concentration of 0.25% increased skin absorption of the drug nearly 3.6 times in the first 15 min. The highest enhancement ratio (ER) was gained in the presence of 1% Transcutol P (ER = 5.98). In this study, among the different topical Finastride formulations, Transcutol P 1% in combination with water, propylene glycol and 2-propanol (30, 10, and 60) showed the highest enhancement ratio.
authors.affiliation: Faculty of Pharmacy and Drug Applied Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran. javadzadehy@yahoo.com
authors.forename: Yousef
authors.initials: Y
authors.lastname: Javadzadeh
authors.forename: Javad
authors.initials: J
authors.lastname: Shokri
authors.forename: Somayeh
authors.initials: S
authors.lastname: Hallaj-Nezhadi
authors.forename: Hamed
authors.initials: H
authors.lastname: Hamishehkar
authors.forename: Ali
authors.initials: A
authors.lastname: Nokhodchi
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000279:Administration, Cutaneous; D000818:Animals; D005026:Ethylene Glycols / Q000737:chemistry; D005079:Excipients / Q000737:chemistry*; D018120:Finasteride / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012869:Skin Absorption; D012997:Solvents / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D058891:5-alpha Reductase Inhibitors; D005026:Ethylene Glycols; D005079:Excipients; D012997:Solvents; D013501:Surface-Active Agents; D018120:Finasteride; C010111:carbitol