title: Five new C21 steroidal glycosides from the stems of Marsdenia tenacissima.
abstract: Five new C(21) steroidal glycosides (1-5) were isolated from the stems of Marsdenia tenacissima. The chemical structures and relative configurations of the new compounds were elucidated by mass spectrometry and NMR spectroscopy. Cellular assay of these compounds showed that they are weak cytotoxic to various cell lines.
authors.affiliation: Jiangsu Simcere Pharmaceutical R&D Co., Ltd., No. 699-18 Xuanwu Avenue, Xuanwu District, Nanjing 210042, PR China. jacal teresa@hotmail.com
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Tan
authors.forename: An-Yuan
authors.initials: AY
authors.lastname: Zhang
authors.forename: Rong
authors.initials: R
authors.lastname: Chen
authors.forename: Shi-Bao
authors.initials: SB
authors.lastname: Yang
authors.forename: Xing
authors.initials: X
authors.lastname: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D031101:Marsdenia / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D013256:Steroids