Effect of granulocytic colony-stimulating factor on cytostatic-suppressed granulocytopoiesis under conditions of exhausted catecholamine depot.
Exhaustion of catecholamine depot in the CNS before modeling of cytostatic myelosuppression potentiates the stimulatory effect of granulocytic CSF on regeneration of the granulocytic hemopoiesis stem. The increase in granulocyte count in the blood system under these conditions is caused by recovery of the structural and functional organization of the hemopoietic tissue (at the expense of reduction of the suppressive effect of catecholamines on the formation of granulocytic hemopoietic islets) and simultaneous stimulation of division and maturation of granulomonocytic precursors.
Dygai
A M
AM
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia. dygay@rambler.ru
Skurikhin
E G
EG
Pershina
O V
OV
Simanina
E V
EV
Minakova
M Yu
MY
Ermakova
N N
NN
Firsova
T V
TV
Khmelevskay
E S
ES
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism*; D003520:Cyclophosphamide / Q000494:pharmacology*; D054697:Cytostatic Agents / Q000494:pharmacology; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006098:Granulocytes / Q000166:cytology* / Q000187:drug effects*; D006410:Hematopoiesis / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology
D002395:Catecholamines; D054697:Cytostatic Agents; D007166:Immunosuppressive Agents; D016179:Granulocyte Colony-Stimulating Factor; D012110:Reserpine; D003520:Cyclophosphamide