title: Relation between visceral fat and coronary artery disease evaluated by multidetector computed tomography.
abstract: Visceral abdominal fat has been associated to cardiovascular risk factors and coronary artery disease (CAD). Computed tomography (CT) coronary angiography is an emerging technology allowing detection of both obstructive and nonobstructive CAD adding information to clinical risk stratification. The aim of this study was to evaluate the association between CAD and adiposity measurements assessed clinically and by CT. We prospectively evaluated 125 consecutive subjects (57% men, age 56.0+/-12 years) referred to perform CT angiography. Clinical and laboratory variables were determined and CT angiography and abdominal CT were performed in a 64-slice scanner. CAD was defined as any plaque calcified or not detected by CT angiography. Visceral and subcutaneous adiposity areas were determined at different intervertebral levels. CT angiography detected CAD in 70 (56%) subjects, and no association was found with usual anthropometric adiposity measurements (waist and hip circumferences and body mass index). Otherwise, CT visceral fat areas (VFA) were significantly related to CAD. VFA T12-L1 values > or =145cm(2) had an odds ratio of 2.85 (95% CI 1.30-6.26) and VFA L4-L5 > or =150cm(2) had a 2.87-fold (95% CI 1.31-6.30) CAD risk. The multivariate analysis determined age and VFA T12-L1 as the only independent variables associated to CAD. Visceral fat assessed by CT is an independent marker of CAD determined by CT angiography.
authors.affiliation: Heart Institute (InCor) University of Sao Paulo Medical School, Brazil.
authors.forename: Mateus D
authors.initials: MD
authors.lastname: Marques
authors.forename: Raul D
authors.initials: RD
authors.lastname: Santos
authors.forename: Jose R
authors.initials: JR
authors.lastname: Parga
authors.forename: Jose A
authors.initials: JA
authors.lastname: Rocha-Filho
authors.forename: Luiz A
authors.initials: LA
authors.lastname: Quaglia
authors.forename: Marcio H
authors.initials: MH
authors.lastname: Miname
authors.forename: Luiz F
authors.initials: LF
authors.lastname: Avila
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002114:Calcinosis / Q000150:complications; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000150:complications* / Q000000981:diagnostic imaging; D012307:Risk Factors; D014057:Tomography, X-Ray Computed / Q000379:methods