Micafungin concentrations from brain tissue and pancreatic pseudocyst fluid.
We report the attainment of micafungin concentrations from brain tissue and pancreatic pseudocyst fluid from two patients with invasive candidiasis. Micafungin was present in low levels at both body sites, indicating limited penetration into central nervous system (CNS) tissue and pancreatic fluid. Further studies are needed to fully characterize its pharmacokinetics at these locations, as micafungin may potentially serve as an alternative antifungal therapy for CNS or pancreatic candidal infections for which the currently recommended first-line therapy fails.
Lat
Asma
A
South Texas Veterans Affairs Health Care System, 4502 Medical Drive, San Antonio, TX 78229, USA.
Thompson
George R
GR
Rinaldi
Michael G
MG
Dorsey
Sheryl A
SA
Pennick
Gennethel
G
Lewis
James S
JS
D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism*; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D054714:Echinocandins / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D055666:Lipopeptides / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008297:Male; D000077551:Micafungin; D010192:Pancreatic Pseudocyst / Q000378:metabolism*
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin