Direct conversion of thiols to sulfonyl chlorides and sulfonamides.
H(2)O(2) in combination with SOCl(2) proved to be a highly reactive reagent for the direct oxidative conversion of thiol derivatives to the corresponding sulfonyl chlorides with high purity through oxidative chlorination. Upon reaction with amines, the corresponding sulfonamides were obtained in excellent yields and in very short reaction times.
Bahrami
Kiumars
K
Department of Chemistry, Razi University, Kermanshah 67149, Iran. kbahrami2@hotmail.com
Khodaei
Mohammad M
MM
Soheilizad
Mehdi
M