Iodine-mediated cyclization of N-thioacyl-1-(2-pyridyl)-1,2-aminoalcohols and their subsequent condensation leading to the formation of novel bis(1-imidazo[1,5-a]pyridyl)arylmethanes.
The treatment of N-thioacyl-1-(2-pyridyl)-1,2-aminoalcohols with iodine and pyridine in THF at room temperature for 30 min leads to the formation of bis(1-imidazo[1,5-a]pyridyl)arylmethanes as green solids in good to high yields.
Tahara
Shinsuke
S
Department of Chemistry, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan.
Shibahara
Fumitoshi
F
Maruyama
Toshifumi
T
Murai
Toshiaki
T
D000605:Amino Alcohols / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003500:Cyclization; D007455:Iodine / Q000737:chemistry*; D008968:Molecular Conformation; D011725:Pyridines / Q000737:chemistry
D000605:Amino Alcohols; D011725:Pyridines; D007455:Iodine; C023666:pyridine