title: Evaluation of the effect of dietary virgin olive oil on blood pressure and lipid composition of serum and low-density lipoprotein in elderly type 2 diabetic subjects.
abstract: Dietary virgin olive oil may help to reduce blood pressure in hypertensive individuals, but little is known about the effect on type 2 diabetic patients. For the present study, 17 type 2 diabetic elderly subjects and 23 healthy elderly controls received a diet rich in virgin olive oil for 4 weeks. Blood pressure, biochemical parameters, low-density lipoprotein (LDL), and oxidized LDL lipids and fatty acids were measured. Systolic blood pressure was reduced after virgin olive oil consumption in both controls and diabetic patients. Although the biochemical parameters were not modified, the intervention protected LDL from oxidation and restored the levels of dihomo-gamma-linolenic acid (20:3, n-6) in serum cholesterol esters and phospholipids of diabetic patients. In conclusion, the present study provides new evidence of the effects of dietary virgin olive oil on blood pressure and LDL oxidation in type 2 diabetics. It is likely that the components responsible for the observed effects are the monounsaturated fatty acids and the presence of antioxidants in the oil, but this needs further investigation.
authors.affiliation: Instituto de la Grasa, Consejo Superior de Investigaciones Cientificas, Sevilla, Spain.
authors.forename: Javier Sanchez
authors.initials: JS
authors.lastname: Perona
authors.forename: Emilio
authors.initials: E
authors.lastname: Montero
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Sánchez-Domínguez
authors.forename: Julio
authors.initials: J
authors.lastname: Cañizares
authors.forename: Maria
authors.initials: M
authors.lastname: Garcia
authors.forename: Valentina
authors.initials: V
authors.lastname: Ruiz-Gutiérrez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood / Q000178:diet therapy / Q000503:physiopathology / Q000517:prevention & control*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000178:diet therapy / Q000503:physiopathology; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage*
chemical_list: D008055:Lipids; D008077:Lipoproteins, LDL; D000069463:Olive Oil; D010938:Plant Oils