Genotype and haplotype determination of interleukin (IL) 1 beta (g. -511C>T and g. +3954C>T) and IL-1RN in polycystic ovary syndrome.
The distribution of genotype frequencies, allele frequencies, and haplotype frequencies of variable number of tandem repeats (VNTR) in interleukin (IL) 1RN and IL-1beta (-511C > T, exon-5C.>T) polymorphism demonstrated a positive association with the occurrence of polycystic ovary syndrome (PCOS). The carriage of allele V of IL-1RN and allele E1 of exon-5 on the IL-1beta gene may increase the risk of PCOS.
Yang
Yan
Y
Department of Obstetrics and Gynecology, Peking University Third Hospital, HaiDian District, Beijing, People's Republic of China.
Qiao
Jie
J
Tang
Rong-Xin
RX
Li
Mei-zhi
MZ
D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D018598:Minisatellite Repeats / Q000235:genetics; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000235:genetics*
D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta