title: Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase.
abstract: A series of benzylidene cyclopentenedione-based inhibitors, acting through covalent modification of the active site of botulinum neurotoxin A light chain metalloprotease, are reported.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Katerina
authors.initials: K
authors.lastname: Capková
authors.forename: Mark S
authors.initials: MS
authors.lastname: Hixon
authors.forename: Sabine
authors.initials: S
authors.lastname: Pellett
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Barbieri
authors.forename: Eric A
authors.initials: EA
authors.lastname: Johnson
authors.forename: Kim D
authors.initials: KD
authors.lastname: Janda
mesh_terms: D001597:Benzylidene Compounds / Q000737:chemistry*; D019274:Botulinum Toxins, Type A / Q000737:chemistry*; D020134:Catalytic Domain; D003517:Cyclopentanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008666:Metalloendopeptidases / Q000737:chemistry* / Q000378:metabolism; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry*
chemical_list: D001597:Benzylidene Compounds; D003517:Cyclopentanes; D011480:Protease Inhibitors; D008666:Metalloendopeptidases; D019274:Botulinum Toxins, Type A; D015032:Zinc; C013905:cyclopentenone