Dietary folate, vitamin B-12, vitamin B-6 and incident Alzheimer's disease: the cache county memory, health and aging study.
OBJECTIVE
To examine associations between dietary and supplemental folate, vitamin B-12 and vitamin B-6 and incident Alzheimer's disease (AD) among elderly men and women.


METHODS
Data collected were from participants of the Cache County Memory, Health and Aging Study, a longitudinal study of 5092 men and women 65 years and older who were residents of Cache County, Utah in 1995.


METHODS
Multistage clinical assessment procedures were used to identify incident cases of AD. Dietary data were collected using a 142-item food frequency questionnaire. Cox Proportional Hazards (CPH) modeling was used to determine hazard ratios across quintiles of micronutrient intake.


RESULTS
202 participants were diagnosed with incident AD during follow-up (1995-2004). In multivariable CPH models that controlled for the effects of gender, age, education, and other covariates there were no observed differences in risk of AD or dementia by increasing quintiles of total intake of folate, vitamin B-12, or vitamin B-6. Similarly, there were no observed differences in risk of AD by regular use of either folate or B6 supplements.


CONCLUSIONS
Dietary intake of B-vitamins from food and supplemental sources appears unrelated to incidence of dementia and AD. Further studies examining associations between dietary intakes of B-vitamins, biomarkers of B-vitamin status and cognitive endpoints are warranted.
Nelson
C
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Department of Nutrition and Food Sciences and Center for Epidemiologic Research, Utah State University, Logan, UT, 84322-8700, USA.
Wengreen
H J
HJ
Munger
R G
RG
Corcoran
C D
CD
D000368:Aged; D000375:Aging / Q000502:physiology / Q000523:psychology; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000378:metabolism / Q000517:prevention & control; D015331:Cohort Studies; D004032:Diet; D019587:Dietary Supplements / Q000706:statistics & numerical data*; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage*; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008568:Memory / Q000502:physiology; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D014589:Utah; D014805:Vitamin B 12 / Q000008:administration & dosage*; D025101:Vitamin B 6 / Q000008:administration & dosage*
D025101:Vitamin B 6; D005492:Folic Acid; D014805:Vitamin B 12