title: New oligo-beta-(1,3)-glucan derivatives as immunostimulating agents.
abstract: Oligo-beta-(1,3)-glucans were chemically modified in order to introduce a structural variation specifically on the reducing end of the oligomers. The impact of well defined structural modulations was further studied on cancer cells and murin models to evaluate their cytotoxicity and immunostimulating potential.
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, Avenue du Général Leclerc, CS 50837, 35708 Rennes Cedex 7, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Descroix
authors.forename: Vaclav
authors.initials: V
authors.lastname: Vetvicka
authors.forename: Isabelle
authors.initials: I
authors.lastname: Laurent
authors.forename: Frank
authors.initials: F
authors.lastname: Jamois
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Yvin
authors.forename: Vincent
authors.initials: V
authors.lastname: Ferrières
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D002236:Carbohydrate Conformation; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology; D008358:Mannose / Q000737:chemistry* / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis / Q000187:drug effects; D047071:beta-Glucans / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000276:Adjuvants, Immunologic; D007376:Interleukin-2; D047071:beta-Glucans; D008358:Mannose