Facile route to 1,3-diazaheterocycle-fused [1,2b]Isoquinolin-1(2H)-one derivatives via substitution-cyclization reactions.
The substitution-cyclization reaction of heterocyclic ketene aminals with polyhalo isophthalonitrile in the presence of t-BuOK to form 1,3-diazaheterocycle fused [1,2-b]isoquinolin-1(2H)-imines, followed by hydrolysis with 1 N HCl, provides a concise and efficient route for the synthesis of highly functional polyhalo 1,3-diazaheterocycle fused [1,2-b]isoquinolin-1(2H)-ones.
Yan
Shengjiao
S
Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, PR China.
Huang
Chao
C
Su
Cunxiang
C
Ni
Yongfen
Y
Lin
Jun
J
D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D007097:Imines / Q000737:chemistry; D007546:Isoquinolines / Q000737:chemistry*; D015394:Molecular Structure
D006571:Heterocyclic Compounds; D007097:Imines; D007546:Isoquinolines