title: Superficial malignant tumors: noninvasive treatment with ultrasonographically guided high-intensity focused ultrasound.
abstract: The purpose of this study was to evaluate the effectiveness of ultrasonographically guided high-intensity focused ultrasound (HIFU) ablation for superficial malignant tumors. HIFU ablation was applied to 38 cases. The diameter of tumors ranged from 1.5-18 cm, including < or =3 cm in seven cases, >3 to < or =5 cm in four cases, >5 to <10 cm in 15 cases, and > or =10 cm in 12 cases. Using imaging techniques, the volume and activity of tumors were observed before and after HIFU ablation, and the effectiveness of HIFU ablation in superficial malignant tumors was evaluated. For tumors < or =5 cm in diameter, HIFU ablation was completely effective in 100% (11/11) of cases; for tumors >5 cm in diameter, HIFU ablation was completely effective in 25.9% (7/27) of cases, partially effective in 14.8% (4/27) of cases, moderately effective in 33.3% (9/27) of cases; the disease remained stable in 14.8% (4/27) of cases and progressed in 11.1% (3/27) of cases. No significant difference was observed in the tumor volumes before (202.6 +/- 230.4 cm(3)) and 6-8 w after HIFU ablation (188.1 +/- 215.8 cm(3)). However, the difference in the active volume before (202.6 +/- 230.4 cm(3)) and after (127.6 +/- 189.7 cm(3)) HIFU ablation was statistically significant. Among 38 the cases, 32 reported painful symptoms, with a pain score of 4.39 +/- 2.36, before the ablation; the values dropped to 0.19 +/- 0.54 after HIFU, and the difference was statistically different. Thus, HIFU is a safe, effective and promising approach for the treatment of superficial malignant tumors.
authors.affiliation: Department of Medical Imaging and Interventional Radiology, Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China.
authors.forename: Chuanxing
authors.initials: C
authors.lastname: Li
authors.forename: Weidong
authors.initials: W
authors.lastname: Zhang
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.forename: Zilin
authors.initials: Z
authors.lastname: Huang
authors.forename: Peihong
authors.initials: P
authors.lastname: Wu
authors.forename: Fujun
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D008297:Male; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000379:methods*; D014463:Ultrasonography