Examination of the MSX1 gene in patients with Parkinson's disease.
BACKGROUND
Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification.


OBJECTIVE
To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD.


METHODS
We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing.


RESULTS
No mutation in the MSX1 gene was identified in our cohort.


CONCLUSIONS
Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.
Deng
H
H
Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, China.
Zhu
S H
SH
Le
W D
WD
Yang
H R
HR
Lv
H W
HW
Xu
H B
HB
Xie
W J
WJ
Jankovic
J
J
D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006801:Humans; D051957:MSX1 Transcription Factor / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010300:Parkinson Disease / Q000175:diagnosis / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D051957:MSX1 Transcription Factor