title: Epigenetic regulation of vertebrate Hox genes: a dynamic equilibrium.
abstract: Temporal and spatial control of Hox gene expression is essential for correct patterning of many animals. In both Drosophila and vertebrates, Polycomb and Trithorax group complexes control the maintenance of Hox gene expression in appropriate domains. In vertebrates, dynamic changes in chromatin modifications are also observed during the sequential activation of Hox genes in the embryo, suggesting that progressive epigenetic modifications could regulate collinear gene activation.
authors.affiliation: National Research Centre Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, Geneva, Switzerland.
authors.forename: Natalia
authors.initials: N
authors.lastname: Soshnikova
authors.forename: Denis
authors.initials: D
authors.lastname: Duboule
mesh_terms: D000818:Animals; D019521:Body Patterning; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics; D044127:Epigenesis, Genetic; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000235:genetics* / Q000378:metabolism; D014714:Vertebrates
chemical_list: D029721:Drosophila Proteins; D018398:Homeodomain Proteins