title: Association between Helicobacter pylori seropositivity and digestive tract cancers.
abstract: OBJECTIVE
  To explore the role of Helicobacter pylori (H pylori) infection on the risk of digestive tract cancers.
  
  
  METHODS
  In total, 199 oral squamous-cell carcinoma (SCC), 317 esophageal SCC, 196 gastric cardia and non-cardia adenocarcinoma and 240 colon adenocarcinoma patients were recruited for serum tests of H pylori infection. Two hospital- and one community-based control groups were used for the comparisons. H pylori seropositivity was determined by an enzyme linked immunosorbent assay method against H pylori IgG.
  
  
  RESULTS
  Presence of H pylori infection was significantly inversely associated with esophageal SCC [adjusted odds ratio (AOR): 0.315-0.472, all P-value < 0.05] but positively associated with gastric adenocarcinoma (both cardia and non-cardia) (AOR: 1.636-3.060, all P-value < 0.05) in comparison to the three control groups. Similar results were not found in cancers of the oral cavity and colon.
  
  
  CONCLUSIONS
  Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, China.
authors.forename: I-Chen
authors.initials: IC
authors.lastname: Wu
authors.forename: Deng-Chyang
authors.initials: DC
authors.lastname: Wu
authors.forename: Fang-Jung
authors.initials: FJ
authors.lastname: Yu
authors.forename: Jaw-Yuan
authors.initials: JY
authors.lastname: Wang
authors.forename: Chao-Hung
authors.initials: CH
authors.lastname: Kuo
authors.forename: Sheau-Fang
authors.initials: SF
authors.lastname: Yang
authors.forename: Chao-Ling
authors.initials: CL
authors.lastname: Wang
authors.forename: Ming-Tsang
authors.initials: MT
authors.lastname: Wu
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000382:microbiology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000382:microbiology*; D002299:Cardia / Q000382:microbiology*; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000150:complications / Q000382:microbiology*; D005260:Female; D016481:Helicobacter Infections / Q000097:blood* / Q000150:complications*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D013274:Stomach Neoplasms / Q000150:complications / Q000382:microbiology*
chemical_list: D000942:Antigens, Bacterial