title: Infrared spectroscopy characterization of normal and lung cancer cells originated from epithelium.
abstract: The vibrational spectral differences of normal and lung cancer cells were studied for the development of effective cancer cell screening by means of attenuated total reflection infrared spectroscopy. The phosphate monoester symmetric stretching nu(s)(PO3(2-)) band intensity at ~970 cm(-1) and the phosphodiester symmetric stretching nu(s)(PO2(-)) band intensity at approximately 1,085 cm(-1) in nucleic acids and phospholipids appeared to be significantly strengthened in lung cancer cells with respect to the other vibrational bands compared to normal cells. This finding suggests that more extensive phosphorylation occur in cancer cells. These results demonstrate that lung cancer cells may be prescreened using infrared spectroscopy tools.
authors.affiliation: Laboratory of Pharmacology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
authors.forename: So Yeong
authors.initials: SY
authors.lastname: Lee
authors.forename: Kyong Ah
authors.initials: KA
authors.lastname: Yoon
authors.forename: Soo Hwa
authors.initials: SH
authors.lastname: Jang
authors.forename: Erdene Ochir
authors.initials: EO
authors.lastname: Ganbold
authors.forename: Dembereldorj
authors.initials: D
authors.lastname: Uuriintuya
authors.forename: Sang Mo
authors.initials: SM
authors.lastname: Shin
authors.forename: Pan Dong
authors.initials: PD
authors.lastname: Ryu
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Joo
mesh_terms: D002277:Carcinoma; D045744:Cell Line, Tumor; D004847:Epithelial Cells / Q000502:physiology*; D006801:Humans; D008175:Lung Neoplasms; D020545:Respiratory Mucosa / Q000166:cytology*; D013055:Spectrophotometry, Infrared