title: Injecting drugs by a tube from appendix stump to colon may be a good method for dealing with refractory ulcerative colitis.
abstract: Ulcerative colitis is a kind of nontransmural chronic inflammatory bowel disease which mainly affects colon and rectum, it has a classic character of the relapsing and remitting course. The main symptoms of ulcerative colitis are intermittent bloody diarrhea, rectal urgency, and tenesmus. As a chronic disease, it can disable and disrupt the daily life of patients. The main treatments for ulcerative colitis are medical management and surgical management, but the drugs used by traditional way have many severe side effects and invalid for refractory ulcerative, and traditional surgery has many complications, so we propose a new treatment of ulcerative colitis, which is the combination of drugs and a little surgery-appendectomy: injecting drugs by a tube from appendix stump to colon after appendectomy by laparoscope, this treatment can decrease the side effects of oral drugs and increase the drug levels as topical managements. Our hypotheses might be an effect way to deal with refractory ulcerative colitis especially total or upper ulcerative colitis, and it is a treatment with little wound and few complications.
authors.affiliation: Gastrointestinal Surgery Center of Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, PR China.
authors.forename: Xiangshang
authors.initials: X
authors.lastname: Xu
authors.forename: Zhixin
authors.initials: Z
authors.lastname: Cao
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Li
authors.forename: Deding
authors.initials: D
authors.lastname: Tao
authors.forename: Junbo
authors.initials: J
authors.lastname: Hu
authors.forename: Chuanyong
authors.initials: C
authors.lastname: Yang
authors.forename: Jianping
authors.initials: J
authors.lastname: Gong
mesh_terms: D000287:Administration, Topical; D001062:Appendectomy; D001065:Appendix / Q000601:surgery*; D002985:Clinical Protocols; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000601:surgery*; D003106:Colon / Q000601:surgery*; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D007267:Injections; D007275:Injections, Intravenous; D012007:Rectum / Q000601:surgery; D012008:Recurrence