Preoperative sensorimotor mapping in brain tumor patients using spontaneous fluctuations in neuronal activity imaged with functional magnetic resonance imaging: initial experience.
OBJECTIVE
To describe initial experience with resting-state correlation mapping as a potential aid for presurgical planning of brain tumor resection.


METHODS
Resting-state blood oxygenation-dependent functional magnetic resonance imaging (fMRI) scans were acquired in 17 healthy young adults and 4 patients with brain tumors invading sensorimotor cortex. Conventional fMRI motor mapping (finger-tapping protocol) was also performed in the patients. Intraoperatively, motor hand area was mapped using cortical stimulation.


RESULTS
Robust and consistent delineation of sensorimotor cortex was obtained using the resting-state blood oxygenation-dependent data. Resting-state functional mapping localized sensorimotor areas consistent with cortical stimulation mapping and in all patients performed as well as or better than task-based fMRI.


CONCLUSIONS
Resting-state correlation mapping is a promising tool for reliable functional localization of eloquent cortex. This method compares well with "gold standard" cortical stimulation mapping and offers several advantages compared with conventional motor mapping fMRI.
Zhang
Dongyang
D
Department of Radiology, Washington University in St. Louis, St. Louis, Missouri 63110, USA. zhangd@npg.wustl.edu
Johnston
James M
JM
Fox
Michael D
MD
Leuthardt
Eric C
EC
Grubb
Robert L
RL
Chicoine
Michael R
MR
Smyth
Matthew D
MD
Snyder
Abraham Z
AZ
Raichle
Marcus E
ME
Shimony
Joshua S
JS
D001931:Brain Mapping / Q000379:methods*; D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D002560:Cerebrovascular Circulation / Q000502:physiology; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005909:Glioblastoma / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D006225:Hand / Q000294:innervation; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D009044:Motor Cortex / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D009068:Movement / Q000502:physiology; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D010291:Paresis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods*; D011597:Psychomotor Performance / Q000502:physiology; D013003:Somatosensory Cortex / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D020886:Somatosensory Disorders / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control