Experimental and computational determination of tRNA dynamics.
As the molecular representation of the genetic code, tRNA plays a central role in the translational machinery where it interacts with several proteins and other RNAs during the course of protein synthesis. These interactions exploit the dynamic flexibility of tRNA. In this minireview, we discuss the effects of modified bases, ions, and proteins on tRNA structure and dynamics and the challenges of observing its motions over the cycle of translation.
Alexander
Rebecca W
RW
Department of Chemistry, Wake Forest University, Winston-Salem, NC 27109-7486, United States. alexanr@wfu.edu
Eargle
John
J
Luthey-Schulten
Zaida
Z
D001483:Base Sequence; D017124:Conserved Sequence; D005815:Genetic Code; D056004:Molecular Dynamics Simulation; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D012343:RNA, Transfer / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
D011506:Proteins; D012343:RNA, Transfer