title: Pyrazolo[3,4-d]pyrimidinophanes: convenient synthesis of a new class of cyclophane and X-ray structure of the first representative.
abstract: A convenient synthesis of a new class of novel pyrazolo[3,4-d]pyrimidinophanes (four products, 41%), a new class of cyclophane, and X-ray structure of the first dissymmetrical [3.4]pyrazolo[3,4-d]pyrimidinophane (22%) are reported for the first time. The conformation of major syn product 6b is stabilized by weak pi-pi and O...Ar interactions.
authors.affiliation: Medicinal and Process Chemistry Division and Molecular and Structural Biology Division, Central Drug Research Institute, CSIR, Lucknow 226001, India. kavasthi@rediffmail.com
authors.forename: Kamlakar
authors.initials: K
authors.lastname: Avasthi
authors.forename: Amantullah
authors.initials: A
authors.lastname: Ansari
authors.forename: Ashish K
authors.initials: AK
authors.lastname: Tewari
authors.forename: Ruchir
authors.initials: R
authors.lastname: Kant
authors.forename: Prakas R
authors.initials: PR
authors.lastname: Maulik
mesh_terms: D018360:Crystallography, X-Ray; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D004988:Ethers, Cyclic; D011720:Pyrazoles; D011743:Pyrimidines