title: Underuse of evidence-based warfarin dosing methods for atrial fibrillation patients.
abstract: BACKGROUND
  The effectiveness of warfarin for stroke prevention in patients with atrial fibrillation is proportional to the time that the International Normalized Ratio is in the therapeutic range. Evidence-based methods (anticoagulation clinic, computerized decision support system or patient self-management) are available to optimize the time in therapeutic range, but there are no data on how often these methods are actually applied in practice. We assessed to what extent generalist and specialist physicians use evidence-based methods for warfarin maintenance dosing.
  
  
  METHODS
  A survey questionnaire on practice characteristics and warfarin management was sent to 409 primary care physicians and 105 specialists (cardiologists, internists and hematologists) in Hamilton, Ontario.
  
  
  CONCLUSIONS
  The survey questionnaire was returned by 233 (57%) of primary care physicians and 57 (54%) of specialists. Compared with specialists, primary care physicians more often managed warfarin solely based on their own experience (33 vs 7%; p<0.001) or with a manual dosing algorithm (22% vs 4%, p<0.001) and less often used one or more evidence-based dosing methods (29 vs 61%; p<0.001). Only 6% of primary care physicians and 2% of specialists (p=0.561) acknowledged having problems with warfarin dosing. Our survey showed that evidence-based methods for warfarin maintenance dosing are underused by primary care physicians and specialists. Closing this gap between knowledge and practice might improve the quality of warfarin control and patient outcomes.
authors.affiliation: Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada. Robby.Nieuwlaat@phri.ca
authors.forename: Robby
authors.initials: R
authors.lastname: Nieuwlaat
authors.forename: Lucy
authors.initials: L
authors.lastname: Barker
authors.forename: Yang-Ki
authors.initials: YK
authors.lastname: Kim
authors.forename: R Brian
authors.initials: RB
authors.lastname: Haynes
authors.forename: John W
authors.initials: JW
authors.lastname: Eikelboom
authors.forename: Salim
authors.initials: S
authors.lastname: Yusuf
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Connolly
mesh_terms: D000554:Ambulatory Care Facilities; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy*; D003625:Data Collection; D006801:Humans; D019934:International Normalized Ratio; D009864:Ontario; D010820:Physicians / Q000706:statistics & numerical data; D010821:Physicians, Family / Q000706:statistics & numerical data*; D012648:Self Care; D011795:Surveys and Questionnaires; D014859:Warfarin / Q000627:therapeutic use*
chemical_list: D014859:Warfarin