title: Unusually rapid beta-cell failure in a patient newly diagnosed with type 2 diabetes presenting acutely with unprovoked severe hyperglycaemic hyperosmolar state: a case report.
abstract: Pancreatic beta-cell failure on a background of insulin resistance results in the inability to compensate for fasting hyperglycaemia and eventually produces type 2 diabetes mellitus. We describe an interesting case of a patient who presented acutely with unprovoked severe hyperglycaemic hyperosmolar state and was subsequently diagnosed with type 2 diabetes mellitus on a background of only impaired first phase insulin secretion 4 months prior. Glucagon stimulation test detected significant beta-cell failure necessitating long term exogenous insulin therapy which is highly unusual by virtue of the rapid apparent deterioration.
authors.affiliation: Department of Endocrinology & Diabetes, Centre for Clinical Research & Effective Practice, Room 33, Support Building, Middlemore Hospital, Otahuhu, South Auckland, Private Bag 93311, New Zealand. drjoeyyeoh@gmail.com
authors.forename: Joey
authors.initials: J
authors.lastname: Yeoh
authors.forename: Judy Chien-Chun
authors.initials: JC
authors.lastname: Huang
authors.forename: Harriet
authors.initials: H
authors.lastname: Cheng
authors.forename: Kenneth Ross
authors.initials: KR
authors.lastname: Muir