Prognostic values of lesion volume and biochemical markers in ischemic and hemorrhagic stroke: a stereological and clinical study.
OBJECTIVE
Our aim was to evaluate the relationship between lesion volume, serum level of biochemical markers, and clinical situation in ischemic and hemorrhagic stroke.


METHODS
MRI was obtained on 33 ischemic and 28 hemorrhagic strokes. The Cavalieri method was used to measure the volume. To evaluate neurological situation of the patients, we used the National Institutes of Health Stroke Scale (NIHSS) and Rankin Disability Scores at the first, third, seventh, and thirtieth days. We measured the level of leptin, high sensitivity C-reactive protein (hs-CRP), insulin, cortisol, fibrinogen, protein C, protein S, von Willebrand factor, D-dimer, Antitrombin III, and Factor VIII (F VIII) at the same time intervals.


RESULTS
In ischemic events, cortisol level at third and seventh days, and fibrinogen level at the first day were correlated with lesion volumes (r = 0.5, p = .02; r = 0.4, p = .02; r = 0.5, p = .005, respectively). In hemorrhagic events, only fibrinogen level was correlated with lesion volumes at third day (r = 0.6, p = .04). No significant differences were found among all these biochemical parameters, neurological situation (p > .05), and lesion volumes at all times.


CONCLUSIONS
In the prediction of stroke prognosis, lesion volume and all of the evaluated biochemical parameters are not deterministic factors.
Varoglu
Asuman Orhan
AO
Department of Neurology, Medical School of Ataturk University, Erzurum, Turkey. asumanorhan@yahoo.com
Kuyucu
Mutlu
M
Demir
Recep
R
Acemoglu
Hamit
H
Can
Ismail
I
Akcay
Fatih
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000097:blood* / Q000378:metabolism / Q000473:pathology*; D004185:Disability Evaluation; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D020300:Intracranial Hemorrhages / Q000097:blood* / Q000378:metabolism / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011379:Prognosis; D020521:Stroke / Q000097:blood* / Q000378:metabolism / Q000473:pathology*; D013997:Time Factors; D055815:Young Adult
D015415:Biomarkers; D005340:Fibrinogen