Nanotechnology applications for improved delivery of antiretroviral drugs to the brain.
Human immunodeficiency virus (HIV) can gain access to the central nervous system during the early course of primary infection. Once in the brain compartment the virus actively replicates to form an independent viral reservoir, resulting in debilitating neurological complications, latent infection and drug resistance. Current antiretroviral drugs (ARVs) often fail to effectively reduce the HIV viral load in the brain. This, in part, is due to the poor transport of many ARVs, in particular protease inhibitors, across the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSBF). Studies have shown that nanocarriers including polymeric nanoparticles, liposomes, solid lipid nanoparticles (SLN) and micelles can increase the local drug concentration gradients, facilitate drug transport into the brain via endocytotic pathways and inhibit the ATP-binding cassette (ABC) transporters expressed at the barrier sites. By delivering ARVs with nanocarriers, significant increase in the drug bioavailability to the brain is expected to be achieved. Recent studies show that the specificity and efficiency of ARVs delivery can be further enhanced by using nanocarriers with specific brain targeting, cell penetrating ligands or ABC-transporters inhibitors. Future research should focus on achieving brain delivery of ARVs in a safe, efficient, and yet cost-effective manner.
Wong
Ho Lun
HL
School of Pharmacy, Temple University, Philadelphia, Pennsylvania 19140, USA.
Chattopadhyay
Niladri
N
Wu
Xiao Yu
XY
Bendayan
Reina
R
D015526:AIDS Dementia Complex / Q000473:pathology / Q000503:physiopathology; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D004337:Drug Carriers; D016503:Drug Delivery Systems; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D053758:Nanoparticles; D036103:Nanotechnology
D018528:ATP-Binding Cassette Transporters; D019380:Anti-HIV Agents; D004337:Drug Carriers