Bioactive constituents of the stem bark of Beilschmiedia zenkeri.
Phytochemical investigation of the stem bark of Beilschmiedia zenkeri led to the isolation of four new methoxylated flavonoid derivatives, (2S,4R)-5,6,7-trimethoxyflavan-4-ol (1), (2S,4R)-4,5,6,7-tetramethoxyflavan (2), beilschmieflavonoid A (3), and beilschmieflavonoid B (4), together with seven known compounds. The structures of 1-4 were established by spectroscopic methods, and their relative configurations confirmed by X-ray crystallographic and CD analysis. The isolated compounds were evaluated in vitro for their antibacterial activity against three strains of bacteria, Pseudomonas agarici, Bacillus subtilis, and Streptococcus minor, and for their antiplasmodial activity against Plasmodium falciparum, chloroquine-resistant strain W2.
Lenta
Bruno Ndjakou
BN
Department of Chemistry, Higher Teachers' Training College, University of Yaoundé 1, P.O. Box 47, Yaoundé, Cameroon.
Tantangmo
Ferdinand
F
Devkota
Krishna Prasad
KP
Wansi
Jean Duplex
JD
Chouna
Jean Rodolphe
JR
Soh
Rene Cosme Fongang
RC
Neumann
Beate
B
Stammler
Hans-Georg
HG
Tsamo
Etienne
E
Sewald
Norbert
N
D001412:Bacillus subtilis / Q000187:drug effects; D002163:Cameroon; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019770:Lauraceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D011549:Pseudomonas / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
D005419:Flavonoids; D002738:Chloroquine