title: Polarization-sensitive optical coherence tomography of necrotizing scleritis.
abstract: A polarization-sensitive swept-source optical coherence tomography system (central wavelength: 1,310 nm; A-line rate: 20 kHz) was developed to evaluate the three-dimensional structure of the anterior eye segment with the phase retardation associated with the anterior segment birefringence of the eyes. Evaluation of normal eyes and an eye with necrotizing scleritis was performed. In the sclera of the normal eyes, a striking polarization change was observed in the cumulative phase retardation images and the boundary of the sclera could be readily detected. In the eye with necrotizing scleritis, phase retardation at the sclera was low in an extensive area; this implied diffuse destruction of the collagen tissue in the sclera had occurred. Polarization-sensitive optical coherence tomography is useful as a contrast engine of the anterior eye segment and for the evaluation of pathological change in the sclera.
authors.affiliation: Department of Ophthalmology, Tokyo Medical University, Kasumigaura Hospital, Inashiki, Ibaraki, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Miura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamanari
authors.forename: Takuya
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Masahide
authors.initials: M
authors.lastname: Itoh
authors.forename: Toyohiko
authors.initials: T
authors.lastname: Yatagai
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yasuno
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005454:Fluorescence Polarization; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D015423:Scleritis / Q000175:diagnosis*; D041623:Tomography, Optical Coherence / Q000379:methods*