[Peroxiredoxins, a new family of antioxidant proteins].
Current ideas are discussed about the structures and mechanisms of action of proteins that have been united at present into a family of thiol-specific antioxidants or peroxiredoxins, which protect the cells of different organisms from the action of hydrogen peroxide. Peroxiredoxins fulfill the same function as antioxidant enzymes such as catalases and glutathione-dependent peroxidases; however, their catalytic activity is lower than that of these enzymes. The level of expression of genes of peroxiredoxins is increased in many pathological states accompanied by oxidative stress, and today there is direct evidence for the important role of peroxiredoxins in the vital activity of cells.
Shuvaeva
T M
TM
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. shuvaeva@mx.ibch.ru
Novoselov
V I
VI
Fesenko
E E
EE
Lipkin
V M
VM
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D054464:Peroxiredoxins / Q000235:genetics / Q000378:metabolism*
D000975:Antioxidants; D054464:Peroxiredoxins