p53 and Metabolism: The GAMT Connection.
In this issue of Molecular Cell, Ide et al. (2009) have identified the enzyme guanidinoacetate methyltransferase (GAMT) that regulates creatine metabolism as a p53 target involved in apoptosis, reactive oxygen species (ROS), and fatty acid metabolism.
Zhu
Yan
Y
Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Prives
Carol
C
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D003401:Creatine / Q000096:biosynthesis; D004249:DNA Damage; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology; D050937:Guanidinoacetate N-Methyltransferase / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008954:Models, Biological; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D005227:Fatty Acids; D016159:Tumor Suppressor Protein p53; C494507:Gamt protein, mouse; D050937:Guanidinoacetate N-Methyltransferase; D005947:Glucose; D003401:Creatine