A stochastic model of cell cycle desynchronization.
A general branching process model is suggested to describe cell cycle desynchronization. Cell cycle phase times are modeled as random variables and a formula for the expected fraction of cells in S phase as a function of time is established. The model is compared to data from the literature and is also compared to previously suggested deterministic and stochastic models.
Olofsson
Peter
P
Trinity University, Mathematics Department, One Trinity Place, San Antonio, TX 78212, USA. polofsso@trinity.edu
McDonald
Thomas O
TO
D002453:Cell Cycle / Q000502:physiology*; D045744:Cell Line, Tumor; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D013269:Stochastic Processes