[The role of micro-ribonucleic acid in disease development].
MicroRNAs (miRNAs) are small non-coding ribonucleic acids (RNAs) consisting of approximately 22 nucleotides which are believed to control posttranscriptional gene expression by targeting messenger RNA (mRNA) either by degradation or silencing. This article focuses on the importance of miRNAs in different diseases. There are observations or even evidence that miRNA is involved in the pathogenesis of diseases such as autoimmune, cancer, cardio-vascular, metabolic and infectious diseases. The manipulation of the expression of one or several specific miRNAs could prove to be a promising treatment option, and may improve diagnostics and therapeutics in future patient care.
Widjaya
Budiman
B
Gastroenheden, Medicinsk Sektion, Herlev Hospital, DK-2730 Herlev, Denmark. bwidjaya@dadlnet.dk
Seidelin
Jakob Benedict
JB
Olsen
Jørgen
J
Nielsen
Ole Haagen
OH
D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006526:Hepatitis C / Q000235:genetics / Q000378:metabolism; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism
D035683:MicroRNAs