Polarity is destiny.
The GTPase Cdc42 specifies polarity in various biological processes. Kesavan et al. (2009) now demonstrate that Cdc42 also regulates epithelial cell polarity in the developing mouse pancreas, where it is required for tubule formation and maintenance. Furthermore, the polarization of epithelial tissue influences the differentiation of pancreatic progenitor cells, linking cell polarity to cell specification.
Cai
Liang
L
Department of Anatomy, University of California, San Francisco, CA 94143-2140, USA.
Mostov
Keith
K
D000818:Animals; D016764:Cell Polarity; D004847:Epithelial Cells / Q000166:cytology; D051379:Mice; D038081:Organogenesis; D010179:Pancreas / Q000166:cytology / Q000196:embryology*