Adult stem cells in tissue engineering.
Tissue engineering is a rapidly evolving field of research that has yet to fulfil its promise in the translation and potential application of adult stem cells in clinical practice. Recently, it has become apparent that specific adult stem cells are capable of transdifferentiation. The successful application of adult stem cells is thought to be central in creating truly biomimetic tissue. Although still most widely utilized, research suggests that in the future, bone marrow-derived stem cells may no longer be considered the most suitable candidates for use in tissue engineering. Independent studies have successfully engineered a range of tissues in vitro and in vivo using hair follicle- and adipose-derived stem cells. Owing to their potency, relative abundance and noninvasive extraction, these populations may be the most promising studied to date. This review aims to discuss these candidate adult stem cell populations in an attempt to assess the most promising avenues of research.
Hodgkinson
Thomas
T
Plastic and Reconstructive Surgery Research, and School of Chemical Engineering and Analytical Science, Manchester Interdisciplinary Biocentre, 131 Princess Street, University of Manchester, Manchester M17DN, UK.
Yuan
Xue-Feng
XF
Bayat
Ardeshir
A
D017667:Adipocytes / Q000166:cytology; D053687:Adult Stem Cells / Q000166:cytology*; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D001842:Bone and Bones / Q000473:pathology; D002356:Cartilage / Q000473:pathology; D018929:Cell Culture Techniques / Q000379:methods; D002454:Cell Differentiation; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D012867:Skin / Q000473:pathology; D023822:Tissue Engineering / Q000379:methods*