Non-polymeric nano-carriers in HIV/AIDS drug delivery and targeting.
Development of an effective drug delivery approach for the treatment of HIV/AIDS is a global challenge. The conventional drug delivery approaches including Highly Active Anti Retroviral Therapy (HAART) have increased the life span of the HIV/AIDS patient. However, the eradication of HIV is still not possible with these approaches due to some limitations. Emergence of polymeric and non-polymeric nanotechnological approaches can be opportunistic in this direction. Polymeric carriers like, dendrimers and nanoparticles have been reported for the targeting of anti HIV drugs. The synthetic pathways as well polymeric framework create some hurdles in their successful formulation development as well as in the possible drug delivery approaches. In the present article, we have discussed the general physiological aspects of the infection along with the relevance of non-polymeric nanocarriers like liposomes, solid lipid nanoparticles (SLN), ethosomes, etc. in the treatment of this disastrous disease.
Gupta
Umesh
U
Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar (M.P.) 470003, India.
Jain
Narendra K
NK
D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D003906:Developing Countries; D004337:Drug Carriers; D016503:Drug Delivery Systems; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008055:Lipids / Q000737:chemistry; D008081:Liposomes; D053758:Nanoparticles; D036103:Nanotechnology / Q000639:trends*; D011108:Polymers; D013535:Suspensions
D019380:Anti-HIV Agents; D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes; D011108:Polymers; D013535:Suspensions