Development and evaluation of a pulsatile drug delivery system using novel polymer. Part II: in vivo radio imaging study.
The objective of the present study was to correlate the results of the in vitro release of a previously reported pulsatile drug delivery system with the in vivo radio imaging study. The formulated drug delivery system containing pellets of barium sulphate was administered to rabbits after overnight fast. Formulated dosage form, previously evaluated for in vitro drug release study, showed drug release after 6-10 h of lag time depending on the hardness as well as the thickness of the plug. Radio imaging study also showed that the plug in the capsule drug delivery system remains intact for the period of 6 h. Thus, the formulated drug delivery system is capable of delaying release in vitro as well as in rabbits for 6 hours.
Tekade
Avinash R
AR
Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur (Dhule), India. avitekade@gmail.com
Gattani
Surendra G
SG
D000818:Animals; D001466:Barium Sulfate / Q000008:administration & dosage* / Q000737:chemistry; D003287:Contrast Media / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D008297:Male; D011108:Polymers / Q000737:chemistry*; D020551:Pulse Therapy, Drug; D011817:Rabbits; D013997:Time Factors
D003287:Contrast Media; D003692:Delayed-Action Preparations; D011108:Polymers; D001466:Barium Sulfate