title: Uncoupling ribosome biogenesis regulation from RNA polymerase I activity during herpes simplex virus type 1 infection.
abstract: The ribosome is the central effector of protein synthesis, and its synthesis is intimately coordinated with that of proteins. At present, the most documented way to modulate ribosome biogenesis involves control of rDNA transcription by RNA polymerase I (RNA Pol I). Here we show that after infection of human cells with herpes simplex virus type 1 (HSV-1) the rate of ribosome biogenesis is modulated independently of RNA Pol I activity by a dramatic change in the rRNA maturation pathway. This process permits control of the ribosome biogenesis rate, giving the possibility of escaping ribosomal stress and eventually allowing assembly of specialized kinds of ribosomes.
authors.affiliation: Centre National de la Recherche Scientifique (CNRS), Université de Lyon, Lyon F-69003, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Belin
authors.forename: Karine
authors.initials: K
authors.lastname: Kindbeiter
authors.forename: Sabine
authors.initials: S
authors.lastname: Hacot
authors.forename: Marie Alexandra
authors.initials: MA
authors.lastname: Albaret
authors.forename: Jean-Xavier
authors.initials: JX
authors.lastname: Roca-Martinez
authors.forename: Gabriel
authors.initials: G
authors.lastname: Thérizols
authors.forename: Olivier
authors.initials: O
authors.lastname: Grosso
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Diaz
mesh_terms: D001483:Base Sequence; D004789:Enzyme Activation; D006367:HeLa Cells; D006561:Herpes Simplex / Q000235:genetics / Q000378:metabolism*; D018259:Herpesvirus 1, Human / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D012318:RNA Polymerase I / Q000378:metabolism* / Q000502:physiology; D012322:RNA Precursors / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional / Q000502:physiology; D012270:Ribosomes / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D012322:RNA Precursors; D012318:RNA Polymerase I