title: In vitro behavior of multifunctionalized fullerene-warfarin conjugates.
abstract: In this study we have covalently linked the anticoagulant warfarin to polyfunctionalized fullerenes. The objective was to explore the possibility of modifying the biological profile of a drug by covalent binding to functionalized fullerene. We have chosen warfarin as a model compound because it a widely used drug. We have analyzed the stability in vitro of the conjugates and found that the drug is released from the carbon support only after incubation in mouse plasma.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Trieste, Piazzale Europa 1, 34127 Trieste, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Zacchigna
authors.forename: Cedric
authors.initials: C
authors.lastname: Klumpp
authors.forename: Maurizio
authors.initials: M
authors.lastname: Prato
authors.forename: Alberto
authors.initials: A
authors.lastname: Bianco
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000737:chemistry*; D037741:Fullerenes / Q000737:chemistry*; D066298:In Vitro Techniques; D051379:Mice; D013056:Spectrophotometry, Ultraviolet; D014859:Warfarin / Q000737:chemistry*
chemical_list: D000925:Anticoagulants; D037741:Fullerenes; D014859:Warfarin