title: Recombinant activated factor VII controls chemotherapy-related hemorrhage in patients with solid intra-abdominal tumors: a report of three pediatric cases.
abstract: Recombinant activated factor VII (rFVIIa; NovoSeven, Novo Nordisk, Bagsvaerd, Denmark) is used predominantly for the treatment of bleeding in patients with hemophilia and inhibitors, and in patients with traumatic injury. There are also literature reports of its use in chemotherapy-related bleeding in leukemia patients and intra- or postoperative bleeding in patients with solid tumors. We describe three pediatric patients where rFVIIa was successfully used to manage bleeding following the failure of conventional hemostatic treatments during chemotherapy for intra-abdominal tumors (hepatoblastoma, rhabdomyosarcoma and non-classified malignant sarcoma). Recombinant FVIIa proved effective and maintained hemostasis in two of three cases, with no evidence for toxic or adverse events in any of the treated patients.
authors.affiliation: Department of Pediatric Hematology and Oncology, University Department of Pediatrics, Zagreb University Hospital Center, Zagreb, Croatia. ernest.bilic@zg.t-com.hr
authors.forename: Ernest
authors.initials: E
authors.lastname: Bilić
authors.forename: Ljubica
authors.initials: L
authors.lastname: Rajić
authors.forename: Ranka
authors.initials: R
authors.lastname: Femenić
authors.forename: Josip
authors.initials: J
authors.lastname: Konja
authors.forename: Katarina
authors.initials: K
authors.lastname: Vucić
authors.forename: Milivoj
authors.initials: M
authors.lastname: Novak
authors.forename: Miran
authors.initials: M
authors.lastname: Cvitković
authors.forename: Slobodan
authors.initials: S
authors.lastname: Galić
authors.forename: Nikola
authors.initials: N
authors.lastname: Krmek
mesh_terms: D000008:Abdominal Neoplasms / Q000188:drug therapy*; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D015942:Factor VIIa / Q000627:therapeutic use*; D006470:Hemorrhage / Q000139:chemically induced* / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa