Specific self-antigen-driven immune response in pericardial effusion as an isolated GVHD manifestation.
Pericardial effusion and cardiac tamponade have been described as GVHD manifestations in the post transplant period. Direct evidence of GVHD-related TCR or B-cell receptor clones in patients with pericardial effusion has never been described. Using several methods, including FACS and spectratyping analysis to assess T- and B-cell clonality and to quantify TCR excision circles to assess newly thymus-derived T cells, we were able to show expansion of oligoclonal T-cell populations and the possible presence of early/premature B cells in the pericardial effusion but not in peripheral mononuclear cells. This may explain the presentation of an isolated GVHD manifestation.
Lev
A
A
Cancer Research Center, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv, Israel.
Amariglio
N
N
Spirer
Z
Z
Katz
U
U
Bielorai
B
B
Rechavi
G
G
Somech
R
R
D000328:Adult; D001324:Autoantigens / Q000276:immunology*; D001402:B-Lymphocytes / Q000473:pathology; D049109:Cell Proliferation; D002999:Clone Cells / Q000276:immunology / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D006086:Graft vs Host Disease / Q000276:immunology* / Q000473:pathology; D006402:Hematologic Diseases / Q000150:complications / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007109:Immunity; D008297:Male; D008875:Middle Aged; D010490:Pericardial Effusion / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology; D055815:Young Adult
D001324:Autoantigens