Effect of zinc supplementation on triglyceride, cholesterol, LDL, and HDL levels in zinc-deficient hemodialysis patients.
BACKGROUND
Zinc deficiency is known to occur in widely diverse areas of world. It has now been recognized in many disease states, such as ESRD patients on maintenance hemodialysis (HD). The purpose of this research was to study the effects of zinc supplementation on the concentration of serum zinc, total cholesterol, triglyceride, and cholesterol fractions (HDL, LDL) in HD patients.


METHODS
In a double blind trial, the effects of oral zinc supplementation on the serum concentration of zinc, total cholesterol, HDL and LDL cholesterol, and triglyceride in HD patients were evaluated.


RESULTS
After 42 days, the mean serum zinc concentration among participants in the zinc-supplemented group increased. There was a significant elevation in the serum total cholesterol and also in mean the serum LDL and HDL cholesterol and serum triglyceride for the subjects in the zinc-supplemented group.


CONCLUSIONS
A suboptimal level of the serum total cholesterol concentration is a factor associated with malnutrition and morbidity in the HD patients. Maintenance HD patients with both low serum zinc and low serum total cholesterol concentrations may benefit from zinc supplementation. Therefore, it is advisable to obtain baseline measurement of the serum zinc and total cholesterol concentrations in maintenance HD patients.
Roozbeh
Jamshid
J
Department of Internal Medicine, Nephrology Division, Urology Nephrology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Hedayati
Parin
P
Sagheb
Mohammad Mahdi
MM
Sharifian
Maryam
M
Hamidian Jahromi
Alireza
A
Shaabani
Sanaz
S
Jalaeian
Hamed
H
Raeisjalali
Ghanbar Ali
GA
Behzadi
Saeed
S
D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003677:Deficiency Diseases / Q000097:blood / Q000188:drug therapy*; D019587:Dietary Supplements; D004311:Double-Blind Method; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis; D014280:Triglycerides / Q000097:blood*; D015032:Zinc / Q000627:therapeutic use*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol; D015032:Zinc