Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits.
Investigation was carried out in adult New Zealand white rabbits to study the influence of curcumin pre-treatment on pharmacokinetic disposition of norfloxacin following single oral administration. Sixteen rabbits were divided into two groups of eight each consisting of either sex. Animals in group-I were administered norfloxacin (100 mg/kg body weight p.o), while animals in group-II received similar dose of norfloxacin after pre-treatment with curcumin (60 mg/kg body weight per day, 3 days, p.o). Blood samples were drawn from the marginal ear vein into heparin-coated vials at 0 (zero time), 5, 10, 15, 30 min and 1, 2, 4, 6, 12 and 24 h post-treatment. Plasma norfloxacin concentrations were determined by high performance liquid chromatography. The plasma concentration-time profile of norfloxacin was adequately described by a one-compartment open model. The pharmacokinetic data revealed that curcumin-treated animals had significantly (p < or = 0.05) higher area under the plasma concentration time curve and area under the first moment of plasma drug concentration-time curve. Prior treatment of curcumin significantly (p < or = 0.05) increased elimination half-life and volume of distribution of norfloxacin. Further treatment with curcumin reduced loading and maintenance doses by 26% and 24% respectively.
Pavithra
B H
BH
Department of Pharmacology and Toxicology, Veterinary College, Karnataka Veterinary, Animal & Fishery Sciences University, Postbox No.6, Bidar-585 401, India.
Prakash
N
N
Jayakumar
K
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D003474:Curcumin / Q000494:pharmacology*; D005260:Female; D006207:Half-Life; D041743:Herb-Drug Interactions; D008297:Male; D009643:Norfloxacin / Q000097:blood / Q000493:pharmacokinetics*; D011817:Rabbits
D000900:Anti-Bacterial Agents; D003474:Curcumin; D009643:Norfloxacin