Successful treatment by paroxetine of delusional disorder, somatic type, accompanied by severe secondary depression.
The case of a 42-year-old woman with delusional disorder, somatic type (DDST), with infestation delusion and delusions of body odor and halitosis accompanied by severe secondary depression is presented. These somatic delusions and depressive symptoms responded favorably to treatment with paroxetine 10 to 30 mg/d. Hypoperfusion in the left temporal and parietal lobes observed when she had marked clinical symptoms was improved at near recovery. The present report suggests that paroxetine is effective and a reasonable drug for DDST with secondary depression. It also supports previous observations that DDST is associated with hypoperfusion in the temporal and parietal lobes.
Hayashi
Hiroshi
H
From the Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan. hhayashi@med.id.yamagata-u.ac.jp
Akahane
Takaki
T
Suzuki
Haruyoshi
H
Sasaki
Tetsuya
T
Kawakatsu
Shinobu
S
Otani
Koichi
K
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology / Q000627:therapeutic use*; D003863:Depression / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D010296:Parietal Lobe / Q000187:drug effects; D017374:Paroxetine / Q000494:pharmacology / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D012563:Schizophrenia, Paranoid / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000187:drug effects
D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine