A case of recurrent immunotactoid glomerulopathy in an allograft treated with rituximab.
Immunotactoid glomerulopathy is a glomerular disorder typified by hollow cylindrical and sometimes spherical microtubular deposits, with a diameter of 30-40 nm, but up to 90 nm, often in a parallel arrangement or in intersecting bundles. These patients frequently end up receiving kidney transplants due to progressive renal insufficiency. Known to recur in renal transplant recipients with variable outcomes, its treatment options are limited. Classically steroids, cyclophosphamide, mycophenolate mofetil, and plasma exchanges have been used to treat these recurrences. More recently, rituximab has been suggested as a treatment and has demonstrated improved outcomes in other glomerular diseases. Herein we describe a case of a middle-aged female renal transplant recipient for end-stage renal disease secondary to immunotactoid glomerulopathy, who experienced a recurrence of this condition in the transplanted kidney. Following a failure of conventional therapy we administered a course of rituximab, resulting in a reduction and stabilization of her serum creatinine level while her proteinuria persisted.
Sathyan
S
S
Department of Transplant Nephrology, Hartford Hospital, Hartford, Connecticut, USA. sharadsathyan@gmail.com
Khan
F N
FN
Ranga
K V
KV
D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D058846:Antibodies, Monoclonal, Murine-Derived; D004359:Drug Therapy, Combination; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D011507:Proteinuria / Q000473:pathology; D012008:Recurrence; D000069283:Rituximab; D016559:Tacrolimus / Q000627:therapeutic use; D014184:Transplantation, Homologous
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D007166:Immunosuppressive Agents; D000069283:Rituximab; D011241:Prednisone; D016559:Tacrolimus