Modulation of monocrotaline-induced cor pulmonale by grape juice.
The study was designed to test whether the ingestion grape juice (GJ) could modulate monocrotaline (MCT)-induced Cor pulmonale resulting from antioxidant properties. Three-week-old male Wistar rats received GJ (10 mL/kg/day) by gavage for 6 weeks. A single injection of MCT (60 mg/kg body weight intraperitoneally) was administered at the end of the third week. Animals were divided in four groups: control, MCT, GJ, and GJ + MCT. MCT promoted a significant increase in right ventricle (36%) and lung (70%) weight to body weight ratio. There was an increase in the right systolic (38%) as well as in the end diastolic (70%) ventricular pressures. MCT caused a significant decrease in lung endothelial nitric oxide synthase (20%) but increase in lipid peroxidation (13%) and catalase (43%). MCT-induced decrease in the endothelial nitric oxide synthase and increase in the right ventricular end diastolic pressure were prevented by GJ, whereas right systolic ventricular pressure and lung weight to body weight ratio were corrected only partially. MCT-induced increase in heart and right ventricle to body weight ratios was not changed by GJ. GJ blunted MCT-induced increase in lipid peroxidation but had no effect on the changes in catalase and superoxide dismutase activities. GJ appears to offer some protection against MCT-induced Cor pulmonale and right ventricle function changes.
Ludke
Ana R L
AR
St. Boniface General Hospital Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada. belklein@ufrgs.br
Mosele
Francisca
F
Caron-Lienert
Rafaela
R
Ribeiro
Maria Flávia
MF
Partata
Wânia
W
Llesuy
Susana
S
Araujo
Alex Sander
AS
Singal
Pawan
P
Belló-Klein
Adriane
A
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001628:Beverages; D001835:Body Weight / Q000187:drug effects; D004195:Disease Models, Animal; D015227:Lipid Peroxidation / Q000187:drug effects; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D016686:Monocrotaline / Q000633:toxicity; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D011660:Pulmonary Heart Disease / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D017725:Ventricular Pressure / Q000187:drug effects; D027843:Vitis / Q000737:chemistry*
D000975:Antioxidants; D016686:Monocrotaline; D052250:Nitric Oxide Synthase Type III