title: SKM-SNP: SNP markers detection method.
abstract: SKM-SNP, SNP markers detection program, is proposed to identify a set of relevant SNPs for the association between a disease and multiple marker genotypes. We employ a subspace categorical clustering algorithm to compute a weight for each SNP in the group of patient samples and the group of normal samples, and use the weights to identify the subsets of relevant SNPs that categorize these two groups. The experiments on both Schizophrenia and Parkinson Disease data sets containing genome-wide SNPs are reported to demonstrate the program. Results indicate that our method can find some relevant SNPs that categorize the disease samples. The online SKM-SNP program is available at http://www.math.hkbu.edu.hk/~mng/SKM-SNP/SKM-SNP.html.
authors.affiliation: Department of Mathematics, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Mark
authors.initials: M
authors.lastname: Li
authors.forename: Yiu M
authors.initials: YM
authors.lastname: Cheung
authors.forename: Pak C
authors.initials: PC
authors.lastname: Sham
authors.forename: Michael K
authors.initials: MK
authors.lastname: Ng
mesh_terms: D000465:Algorithms; D016000:Cluster Analysis; D016208:Databases, Factual; D005819:Genetic Markers; D023281:Genomics / Q000379:methods; D006801:Humans; D008490:Medical Informatics / Q000379:methods*; D010300:Parkinson Disease / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software
chemical_list: D005819:Genetic Markers