title: Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets.
abstract: Interleukin-15 receptor alpha (IL-15R alpha) is a pleiotropically expressed molecule that chaperones and trans-presents IL-15 to NK and T cells. To investigate whether IL-15R alpha presented by different cells perform distinct physiological functions, we have generated four lines of mice lacking IL-15R alpha in various cell types. We find that IL-15R alpha expression on macrophages but not dendritic cells (DCs) supports the early transition of antigen specific effector CD8(+) T cells to memory cells. After memory CD8(+) T cell differentiation, IL-15R alpha expression on DCs selectively supports central memory CD8(+) T cells, whereas IL-15R alpha expression on macrophages supports both central and effector memory CD8(+) T cells. By contrast, mice lacking IL-15R alpha on macrophages, DCs, or both, exhibit equivalent defects in NK cell homeostasis and activation. These studies define unique roles for macrophage expression of IL-15R alpha and show that NK cells rely upon distinct IL-15R alpha dependent IL-15 signals than memory CD8(+) T cells. Moreover, they demonstrate the diversity, specification, and geographic restriction of cytokine signals.
authors.affiliation: Department of Medicine, University of California, San Francisco, San Francisco, CA 94143-0451, USA.
authors.forename: Erwan
authors.initials: E
authors.lastname: Mortier
authors.forename: Rommel
authors.initials: R
authors.lastname: Advincula
authors.forename: Leesun
authors.initials: L
authors.lastname: Kim
authors.forename: Stephen
authors.initials: S
authors.lastname: Chmura
authors.forename: Julio
authors.initials: J
authors.lastname: Barrera
authors.forename: Boris
authors.initials: B
authors.lastname: Reizis
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Malynn
authors.forename: Averil
authors.initials: A
authors.lastname: Ma
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D017353:Gene Deletion; D006706:Homeostasis; D007156:Immunologic Memory; D053720:Interleukin-15 Receptor alpha Subunit / Q000235:genetics / Q000378:metabolism*; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008822:Mice, Transgenic; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000378:metabolism
chemical_list: D053720:Interleukin-15 Receptor alpha Subunit; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7