Increase in the oxidized/total coenzyme Q-10 ratio in the cerebrospinal fluid of Alzheimer's disease patients.
OBJECTIVE
The contribution of mitochondrial dysfunction and oxidative stress to the pathogenesis of Alzheimer's disease (AD) has previously been described. We aimed to investigate whether the balance between the oxidized and reduced forms of coenzyme Q-10 (CoQ-10) is related to the pathogenesis of AD.


METHODS
Thirty patients with AD (69.0 +/- 4.1 years) and 30 healthy control subjects (63.8 +/- 16.4 years) were enrolled in this study. Concentrations of oxidized CoQ-10 and reduced CoQ-10 were measured by high-performance liquid chromatography using an electrochemical detector.


RESULTS
The percentage of oxidized/total CoQ-10 in the cerebrospinal fluid (%CoQ-10, CSF) was significantly higher in the untreated AD group (78.2 +/- 18.8%) than in the control group (41.3 +/- 10.4%, p < 0.001), and there was a significant negative correlation between %CoQ-10 and the duration of the illness (r(s) = -0.93, p < 0.001).


CONCLUSIONS
These findings in living AD patients suggest a possible role for %CoQ-10 in the pathogenesis of the early stage of AD development.
Isobe
Chiaki
C
Department of Neurology, Iwate Medical University, Morioka, Japan. chiso@apost.plala.or.jp
Abe
Takashi
T
Terayama
Yasuo
Y
D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000209:etiology*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002851:Chromatography, High Pressure Liquid; D018450:Disease Progression; D004579:Electron Transport / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D028361:Mitochondrial Diseases / Q000134:cerebrospinal fluid* / Q000150:complications*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000134:cerebrospinal fluid / Q000737:chemistry
D015415:Biomarkers; D014451:Ubiquinone; C026663:ubiquinol-10; C024989:coenzyme Q10