Peroxidation processes in rats during the delayed period after chronic administration of dihydroquercetin.
Peroxidation processes in male outbred albino rats were studied 1, 2, and 3 months after 90-fold administration of dihydroquercetin in doses of 86, 860, and 3000 mg/kg and flavonoid rutin (reference preparation) in a dose of 86 mg/kg. Dihydroquercetin in a dose of 86 mg/kg was as potent as rutin in modulating the process of peroxidation. Changes in the nonenzymatic antioxidant system and activation of lipid peroxidation were not observed in the delayed period after administration of dihydroquercetin.
Chernyak
Yu I
YI
Angarsk Branch, Institute of Labor Medicine and Human Ecology, Research Center of Medical Ecology, East-Siberian Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia. yuri_chernyak@ang.ru
Shchukina
O G
OG
D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats
D000975:Antioxidants; D011794:Quercetin; C003377:taxifolin; D001205:Ascorbic Acid