title: Case report: unicameral bone cysts in a young patient with acquired generalized lipodystrophy.
abstract: We report the case of a 13-year-old boy with bilateral distal femoral unicameral bone cysts (UBCs) associated with acquired generalized lipodystrophy. As opposed to congenital generalized lipodystrophy, cystic bone lesions in acquired generalized lipodystrophy are rare. After radiographic and histologic confirmation of the UBCs, we performed percutaneous intramedullary decompression, curettage, and grafting. UBCs can be an important manifestation of acquired generalized lipodystrophy. Cystic bone lesions appear to be less common in acquired generalized lipodystrophy than in congenital generalized lipodystrophy, and intramedullary adipose tissue loss may be a predisposing factor for the development of bone lesions in patients with acquired generalized lipodystrophy. When evaluating a patient with lipodystrophy, doctors should recognize the clinical course may include the development of UBCs.
authors.affiliation: Department of Orthopaedic Surgery, Rush University, Chicago, IL, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Gregory
authors.forename: Alexandre
authors.initials: A
authors.lastname: Arkader
authors.forename: Aqiba
authors.initials: A
authors.lastname: Bokhari
authors.forename: Aqiba
authors.initials: A
authors.lastname: Bothari
authors.forename: John P
authors.initials: JP
authors.lastname: Dormans
mesh_terms: D000293:Adolescent; D001706:Biopsy; D001845:Bone Cysts / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D003937:Diagnosis, Differential; D005269:Femur; D005500:Follow-Up Studies; D006801:Humans; D052497:Lipodystrophy, Congenital Generalized / Q000150:complications* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male