Preclinical mouse models for BRCA1-associated breast cancer.
A substantial part of all hereditary breast cancer cases is caused by BRCA1 germline mutations. In this review, we will discuss the insights into BRCA1 functions that we obtained from mouse models with conventional and conditional mutations in Brca1. The most advanced models closely resemble human BRCA1-related breast cancer and may therefore be useful for addressing clinically relevant questions.
Drost
R M
RM
Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands.
Jonkers
J
J
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics*; D004195:Disease Models, Animal; D005260:Female; D019398:Genes, BRCA1; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout