title: BmKCT toxin inhibits glioma proliferation and tumor metastasis.
abstract: Malignant gliomas are the most common primary brain tumors associated with significant morbidity and mortality. How to target the tumor in situ, and inhibit tumor cell proliferation and invasion is the key for therapy. Gliomas express a glioma-specific chloride ion channel that is sensitive to toxins including BmKCT. In the current study, the inhibitory effect of BmKCT on glioma growth was observed in vivo using the glioma/SD rat model. Furthermore, BmKCT prevented the metastasis of glioma cells in vivo. Moreover, biodistribution experiments with (l3l)I-labeled or Cy5.5-conjugated BmKCT revealed that BmKCT selectively targeted the glioma in situ. Our data suggest that BmKCT could be exploited as a potential therapeutic for glioma diagnosis and therapy.
authors.affiliation: State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei, 430072, PR China.
authors.forename: Shaozhong
authors.initials: S
authors.lastname: Fan
authors.forename: Zhengbo
authors.initials: Z
authors.lastname: Sun
authors.forename: Dahe
authors.initials: D
authors.lastname: Jiang
authors.forename: Chao
authors.initials: C
authors.lastname: Dai
authors.forename: Yibao
authors.initials: Y
authors.lastname: Ma
authors.forename: Zhenhuan
authors.initials: Z
authors.lastname: Zhao
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Yingliang
authors.initials: Y
authors.lastname: Wu
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Cao
authors.forename: Wenxin
authors.initials: W
authors.lastname: Li
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor / Q000187:drug effects; D003001:Cloning, Molecular; D005260:Female; D005784:Gene Amplification; D005910:Glioma / Q000188:drug therapy / Q000473:pathology*; D005982:Glutathione Transferase / Q000378:metabolism; D009362:Neoplasm Metastasis / Q000473:pathology* / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley; D012604:Scorpion Venoms / Q000235:genetics / Q000627:therapeutic use* / Q000633:toxicity; D012605:Scorpions; D012979:Sodium Radioisotopes / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: C109066:KTX toxin, Buthus; D012604:Scorpion Venoms; D012979:Sodium Radioisotopes; D005982:Glutathione Transferase