Histological and immunohistochemical characterization of AT/RT: a report of 15 cases from India.
Atypical teratoid rhabdoid tumor (AT/RT) is a highly malignant embryonal CNS tumor, generally unresponsive to any form of therapy, uniformly fatal within 1 year. We report 15 cases of AT/RT diagnosed at our center over a period of 5 years (2003-08). Tumors were located in different sites of the neuraxis, posterior fossa being the most common (n = 10) followed by cerebral lobes (n = 3). There was one each at the supra sellar and cervical spinal regions, respectively. Radiologically most of the tumors were heterodense and enhancing heterogeneously. The tumors exhibited diverse histological profile that included rhabdoid and PNET areas in all cases, mesenchymal and epithelial areas in 73.3% and 53.3% cases, respectively. Necrosis was evident in all cases and one showed calcification. Tumor cells displayed a polyphenotypic immunoprofile. All cases were consistently positive for vimentin and epithelial membrane antigen and were negative for desmin. Variable positivity was seen for other markers. The number of cases positive for these were: CK (53%), SMA (60%), synaptophysin (66%), NFP (33.3%) and GFAP (85%). CK staining was prominent in epithelial areas, while PNET cells labeled prominently with synaptophysin. There was lack of INI1 expression in all cases. Follow-up was available in 46.6% of cases which revealed a uniform poor prognosis.
Mohapatra
Ishani
I
Department of Neuropathology, National Institutes of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
Santosh
Vani
V
Chickabasaviah
Yasha T
YT
Mahadevan
Anita
A
Tandon
Ashwani
A
Ghosh
Amrita
A
Chidambaram
Balasubramaniam
B
Sampath
Somanna
S
Bhagavatula
Indira Devi
ID
Chandramouli
Bangalore Ashwathnarayana
BA
Kolluri
Shastry V R
SV
Shankar
Susarla Krishna
SK
D016543:Central Nervous System Neoplasms / Q000737:chemistry* / Q000276:immunology / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007194:India; D007223:Infant; D008297:Male; D009336:Necrosis; D012189:Retrospective Studies; D018335:Rhabdoid Tumor / Q000737:chemistry* / Q000276:immunology / Q000473:pathology*; D013724:Teratoma / Q000737:chemistry* / Q000276:immunology / Q000473:pathology*