Drugs controlling proteinuria of patients with Alport syndrome.
BACKGROUND
Proteinuria is one of the risk factors for the progression of renal diseases including Alport syndrome (AS), a hereditary glomerular renal disease. This study aimed to evaluate the efficacy of angiotensin converting enzyme inhibitors (ACEIs) and/or tripterygium, a Chinese herbal medicine widely used in Chinese patients with hematuria and proteinuria, on proteinuria in patients with AS.


METHODS
Twenty-nine children were enrolled into this retrospective study. Patients were divided into 3 therapy groups: ACEI group, tripterygium group, and ACEI plus tripterygium group.


RESULTS
In the 29 children, 23 were male and 6 female. In the ACEI group and the tripterygium group, the effective rate was 87.5% and 25.0%, respectively and in the ACEI plus tripterygium group was 42.9%.


CONCLUSIONS
ACEI is effective in controlling proteinuria of AS patients. Tripterygium should be carefully administered in controlling proteinuria of AS patients.
Li
Jian-Guo
JG
Department of Pediatrics, Peking University First Hospital, Beijing, 100034, China.
Ding
Jie
J
Wang
Fang
F
Zhang
Hong-Wen
HW
D000293:Adolescent; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002648:Child; D018450:Disease Progression; D004365:Drugs, Chinese Herbal; D005260:Female; D006801:Humans; D008297:Male; D009394:Nephritis, Hereditary / Q000150:complications / Q000188:drug therapy*; D008517:Phytotherapy; D011507:Proteinuria / Q000188:drug therapy* / Q000209:etiology; D029757:Tripterygium
D000806:Angiotensin-Converting Enzyme Inhibitors; D004365:Drugs, Chinese Herbal