title: Acute effects of pharmacotherapies in blood pressure in normotensive moderate smokers.
abstract: This study was designed to evaluate the changes in arterial blood pressure (BP) and heart rate (HR) in moderate smokers during smoking abstinence after 7 days of treatment with bupropion alone, transdermal nicotine or bupropion combined with transdermal nicotine. Twenty-four healthy moderate smokers (12 female/12 male; 40+/-7 years) were evaluated randomly on five occasions and their systolic, diastolic, mean arterial blood pressure (MAP) and HR were measured by a Finapres device for 10 h, immediately after smoking interruption. All of the 24 smokers participated on five protocols during 7 days: control group (C) - no drugs; placebo group (PL); bupropion group (BUP) 150-300 mg; transdermal nicotine group (TN) - 21 mg; and BUP+TN-nicotine patch. Concomitantly, the subjects were evaluated by ABPM (ambulatory BP monitoring). All of BP parameters monitored shown significant statistical differences in the BUP, TN and BUP+TN groups compared with the controls (p<0.05), when measured by Finapres. The HR remained unaltered in all of the groups. No significant differences were seen in the BP or HR during the 24-h ABPM. These findings indicate that in moderate smokers, bupropion, transdermal nicotine or bupropion associated with transdermal nicotine caused an elevation in the BP after acute smoking interruption.
authors.affiliation: Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil.
authors.forename: Luíz Cláudio
authors.initials: LC
authors.lastname: Martins
authors.forename: Sílvia Elaine
authors.initials: SE
authors.lastname: Ferreira-Melo
authors.forename: Maricene
authors.initials: M
authors.lastname: Sabha
authors.forename: Otávio Rizzi
authors.initials: OR
authors.lastname: Coelho
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Yugar-Toledo
authors.forename: Thiago
authors.initials: T
authors.lastname: Quinaglia
authors.forename: Marcos Mello
authors.initials: MM
authors.lastname: Moreira
authors.forename: Antonio
authors.initials: A
authors.lastname: Coca
authors.forename: Heitor
authors.initials: H
authors.lastname: Moreno Júnior
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D016642:Bupropion / Q000008:administration & dosage* / Q000009:adverse effects; D018592:Cross-Over Studies; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage* / Q000009:adverse effects; D016037:Single-Blind Method; D012907:Smoking / Q000503:physiopathology*; D016540:Smoking Cessation / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D016642:Bupropion; D009538:Nicotine