Gender differences among patients with secondary hyperparathyroidism undergoing parathyroidectomy.
OBJECTIVE
Female gender is associated with an increased risk of parathyroid nodular hyperplasia and parathyroidectomy rate in dialysis patients. The purpose of this study was to assess differences between women and men undergoing parathyroidectomy for secondary hyperparathyroidism.


METHODS
We reviewed 121 consecutive patients with end-stage renal disease and advanced secondary hyperparathyroidism who underwent parathyroidectomy between 2004 and 2007. Preoperative characteristics and short-term outcome of these patients were evaluated.


RESULTS
Compared with men (n = 43), women (n = 78) had lower preoperative bone mineral density (both T-scores and Z-scores) as well as lower preoperative hemoglobin levels. The cause of renal failure was also different between the two groups. No differences in preoperative calcium-phosphorus product, alkaline phosphatase, or parathyroid hormone levels were observed. Follow-up analysis showed that biochemical improvement and 1-y recurrence rate was similar between genders.


CONCLUSIONS
Women with secondary hyperparathyroidism had worse bone mineral metabolism before parathyroidectomy. Additional research regarding target organ susceptibility to hyperparathyroidism in different genders is warranted.
Cheng
Shih-Ping
SP
Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan.
Yang
Tsen-Long
TL
Lee
Jie-Jen
JJ
Chen
Han-Hsiang
HH
Wu
Chih-Jen
CJ
Liu
Tsang-Pai
TP
Liu
Chien-Liang
CL
D000293:Adolescent; D000328:Adult; D000368:Aged; D015519:Bone Density; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000378:metabolism / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000378:metabolism; D016105:Parathyroidectomy; D011446:Prospective Studies; D012008:Recurrence; D012189:Retrospective Studies; D012727:Sex Characteristics; D016896:Treatment Outcome; D055815:Young Adult
D006454:Hemoglobins; D010281:Parathyroid Hormone