Progressive resistance exercise improves glycaemic control in people with type 2 diabetes mellitus: a systematic review.
OBJECTIVE
Is progressive resistance exercise a safe and effective form of exercise to improve glycaemic control in people with type 2 diabetes?


METHODS
Systematic review with meta-analysis of randomised controlled trials.


METHODS
People with type 2 diabetes mellitus.


METHODS
Progressive resistance exercise.


METHODS
The primary outcome was glycaemic control measured as percentage glycosylated haemoglobin (HbA1c). Secondary outcomes were body composition (lean body and fat free mass in kg), and muscle strength (% change in 1RM, dynamometry, change in maximum weight lifted).


RESULTS
The search yielded nine relevant trials that evaluated 372 people with type 2 diabetes. Compared to not exercising, progressive resistance exercise led to small and statistically significant absolute reductions in HbA1c of 0.3% (SMD -0.25, 95% CI -0.47 to -0.03). When compared to aerobic exercise there were no significant differences in HbA1c. Progressive resistance exercise resulted in large improvements in strength when compared to aerobic (SMD 1.44, 95% CI 0.83 to 2.05) or no exercise (SMD 0.95, 95% CI 0.58 to 1.31). There were no significant changes in body composition.


CONCLUSIONS
Progressive resistance exercise increases strength and leads to small reductions in glycosylated haemoglobin that are likely to be clinically significant for people with type 2 diabetes. Progressive resistance exercise is a feasible option in the management of glycaemia for this population.
Irvine
Casey
C
Physiotherapy, Peter James Centre, Eastern Health, Melbourne, Victoria 3131, Australia. Casey.Peiris@easternhealth.org.au
Taylor
Nicholas F
NF
D001786:Blood Glucose / Q000378:metabolism*; D001823:Body Composition / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D017063:Outcome Assessment, Health Care; D055070:Resistance Training / Q000379:methods*
D001786:Blood Glucose; D006442:Glycated Hemoglobin