title: Flash-phase images to detect coronary artery stenosis: a novel finding during contrast-echocardiography.
abstract: Flash-replenishment sequences are commonly used during contrast stress-echocardiography to detect regions subtended by significant coronary artery disease, which show slower replenishment compared with normal regions at peak stress. We have discovered that the images obtained during the first part of the sequence, made by a series of high mechanical index (MI) impulses (called 'flash' impulses), can in fact portend substantial information on myocardial perfusion independently by the analysis of the following replenishment phase. We describe this novel finding in a paradigmatic case. Flash-replenishment sequences are commonly used during contrast stress-echocardiography to detect regions subtended by significant coronary artery disease, which show slower replenishment compared with normal regions at peak stress. We have discovered that the images obtained during the first part of the sequence, made by a series of high-MI impulses (called 'flash' impulses), can in fact portend substantial information on myocardial perfusion independently by the analysis of the following replenishment phase. We describe this novel finding in a paradigmatic case.
authors.affiliation: Dipartimento Cardio-Polmonare, Parma University Hospital, Via Gramsci 14-43100, Parma, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Gaibazzi
authors.forename: Angelo
authors.initials: A
authors.lastname: Squeri
authors.forename: Claudio
authors.initials: C
authors.lastname: Reverberi
mesh_terms: D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D004176:Dipyridamole; D004452:Echocardiography / Q000379:methods*; D006801:Humans; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging*; D010743:Phospholipids; D013459:Sulfur Hexafluoride; D014665:Vasodilator Agents
chemical_list: D010743:Phospholipids; D014665:Vasodilator Agents; C420843:contrast agent BR1; D004176:Dipyridamole; D013459:Sulfur Hexafluoride