Effects of Athamanta turbith fruit essential oils on CCl4-induced hepatic failure in mice and their antioxidant properties.
The effects of essential oils isolated from mature fruits of Athamanta turbith ssp. hungarica (Borbás) Tutin and A. turbith ssp. haynaldii (Borbás & Uechtr.) Tutin (Umbelliferae) on some liver biochemical parameters in mice intoxicated with carbon tetrachloride were investigated. Pretreatment with both essential oils extenuated the effects caused by carbon tetrachloride. In order to investigate in vitro antioxidant properties of the oils, three methods were applied: scavenging of both 2,2-diphenyl-1-picrylhydrazyl (DPPH) and OH radicals, as well as a test of inhibition of Fe(2+)/ascorbic-induced lipid peroxidation. Investigated essential oils exhibited modest antioxidant capacity. Therefore, their influence on biochemical parameters in intoxicated animals might be linked to the inhibition of enzymes (cytochrome P450 2E1) involved in metabolic activation of halomethanes.
Tomić
Ana
A
Institute of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Bozin
Biljana
B
Samojlik
Isidora
I
Milenković
Marina
M
Mimica-Dukić
Neda
N
Petrović
Silvana
S
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000378:metabolism; D002251:Carbon Tetrachloride; D016166:Free Radical Scavengers / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D017665:Hydroxyl Radical / Q000378:metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D017093:Liver Failure / Q000188:drug therapy*; D008297:Male; D051379:Mice; D009822:Oils, Volatile / Q000494:pharmacology*; D010851:Picrates / Q000378:metabolism; D010938:Plant Oils / Q000494:pharmacology*
D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D009822:Oils, Volatile; D010851:Picrates; D010938:Plant Oils; D017665:Hydroxyl Radical; D002251:Carbon Tetrachloride; C004931:1,1-diphenyl-2-picrylhydrazyl