Development of Churg-Strauss syndrome with severe multiple mononeuropathy after leukotriene receptor antagonist treatment in one of the monozygotic twins with asthma: case report.
Several cases of Churg-Strauss syndrome (CSS) have been reported in asthmatic patients treated with leukotriene receptor antagonists (LTRAs). It is not clear whether LTRA is a causative factor in the development of vasculitis. We present the case of a 26-year-old patient, who developed severe central and peripheral neuropathy after a short-term treatment with LTRA, followed by gastrointestinal perforation and bleeding. The patient was successfully treated with high-dose glucocorticoids, immunoglobulins, and cyclophosphamide. His monozygotic twin brother treated for asthma does not meet classification criteria for Churg-Strauss syndrome at the moment, but his condition is being monitored. Both asthma and rheumatology specialists should consider the possibility of CSS development in patients treated with LTRAs.
Targońska-Stepniak
Bozena
B
Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Lublin, Poland. bozena.stepniak@am.lublin.pl
Majdan
Maria
M
Haberek
Grzegorz
G
Papuć
Ewa
E
Wnukowska
Kinga
K
D000328:Adult; D018927:Anti-Asthmatic Agents / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy; D015267:Churg-Strauss Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D004200:Diseases in Twins / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D020024:Leukotriene Antagonists / Q000009:adverse effects*; D008297:Male; D020422:Mononeuropathies / Q000139:chemically induced* / Q000175:diagnosis; D014430:Twins, Monozygotic
D018927:Anti-Asthmatic Agents; D020024:Leukotriene Antagonists