Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development.
Recent observations highlight that the mammalian genome extensively communicates with itself via long-range chromatin interactions. The causal link between such chromatin cross-talk and epigenetic states is, however, poorly understood. We identify here a network of physically juxtaposed regions from the entire genome with the common denominator of being genomically imprinted. Moreover, CTCF-binding sites within the H19 imprinting control region (ICR) not only determine the physical proximity among imprinted domains, but also transvect allele-specific epigenetic states, identified by replication timing patterns, to interacting, nonallelic imprinted regions during germline development. We conclude that one locus can directly or indirectly pleiotropically influence epigenetic states of multiple regions on other chromosomes with which it interacts.
Sandhu
Kuljeet Singh
KS
Department of Development and Genetics, Evolution Biology Centre, Uppsala University, S-752 36 Uppsala, Sweden.
Shi
Chengxi
C
Sjölinder
Mikael
M
Zhao
Zhihu
Z
Göndör
Anita
A
Liu
Liang
L
Tiwari
Vijay K
VK
Guibert
Sylvain
S
Emilsson
Lina
L
Imreh
Marta P
MP
Ohlsson
Rolf
R
D000483:Alleles; D000818:Animals; D002478:Cells, Cultured; D053595:Embryonic Stem Cells; D005260:Female; D018507:Gene Expression Regulation, Developmental; D018392:Genomic Imprinting / Q000235:genetics*; D005854:Germ Cells / Q000254:growth & development* / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated
C094335:H19 long non-coding RNA; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated