title: The relationship between ACE gene ID polymorphism and aerobic capacity in Asian rugby players.
abstract: BACKGROUND
  The aim of this study was to analyse the association between the ACE ID polymorphism and aerobic capacity in a homogeneous cohort of national Asian rugby players.
  
  
  METHODS
  17 subjects recruited during active training had their maximal oxygen uptake (V0 2 max) and ventilatory threshold (VT) measured during maximal exercise testing. ACE genotyping was performed for all players.
  
  
  RESULTS
  The likelihood of having a V0 2 max above the 80th percentile of a gender-specific reference range for a normal population was 14.3-fold greater among subjects with the II genotype as compared to the ID genotype (p-value is 0.030). Similarly, subjects with the II genotype were 29.4 times more likely to have a VT above the gender-specific median value compared to the ID genotype (p-value is 0.019). The results suggest that the I allele confers an advantage in aerobic capacity as measured by the V0 2 max and VT.
  
  
  CONCLUSIONS
  It is likely that the same physiological mechanisms mediated by the ACE gene are responsible for aerobic capacity in both Asians and Caucasians.
authors.affiliation: Department of Medicine, Alexandra Hospital, 378 Alexandra Road, Singapore. kian_peng_goh@alexhosp.com.sg
authors.forename: K P
authors.initials: KP
authors.lastname: Goh
authors.forename: K
authors.initials: K
authors.lastname: Chew
authors.forename: A
authors.initials: A
authors.lastname: Koh
authors.forename: M
authors.initials: M
authors.lastname: Guan
authors.forename: Y S
authors.initials: YS
authors.lastname: Wong
authors.forename: C F
authors.initials: CF
authors.lastname: Sum
mesh_terms: D000293:Adolescent; D000328:Adult; D001208:Asia; D044466:Asian People; D056352:Athletes; D015331:Cohort Studies; D005260:Female; D005538:Football; D006801:Humans; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010807:Physical Endurance / Q000502:physiology*; D011110:Polymorphism, Genetic; D044465:White People
chemical_list: D007703:Peptidyl-Dipeptidase A