title: Differences among group A streptococcus epidemiological landscapes: consequences for M protein-based vaccines?
abstract: Group A streptococcus (GAS) is a bacterial pathogen responsible for a wide array of disease pathologies in humans. GAS surface M protein plays multiple key roles in pathogenesis, and serves as a target for typing and vaccine development. In this review, we have compiled GAS epidemiological studies from several countries around the world to highlight the consequences on the theoretical efficacy of two different M protein-based vaccine strategies.
authors.affiliation: Bacterial Pathogenesis Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia. psmeeste@ulb.ac.be
authors.forename: Pierre R
authors.initials: PR
authors.lastname: Smeesters
authors.forename: David J
authors.initials: DJ
authors.lastname: McMillan
authors.forename: Kadaba S
authors.initials: KS
authors.lastname: Sriprakash
authors.forename: Melina M
authors.initials: MM
authors.lastname: Georgousakis
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology*; D015195:Drug Design; D014644:Genetic Variation; D014943:Global Health; D006801:Humans; D017720:Molecular Epidemiology; D012720:Severity of Illness Index; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control*; D022541:Streptococcal Vaccines / Q000008:administration & dosage / Q000276:immunology; D013297:Streptococcus pyogenes / Q000235:genetics* / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; D022541:Streptococcal Vaccines; C014689:streptococcal M protein