title: Examination of the MSX1 gene in patients with Parkinson's disease.
abstract: BACKGROUND
  Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification.
  
  
  OBJECTIVE
  To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD.
  
  
  METHODS
  We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing.
  
  
  RESULTS
  No mutation in the MSX1 gene was identified in our cohort.
  
  
  CONCLUSIONS
  Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.
authors.affiliation: Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, China.
authors.forename: H
authors.initials: H
authors.lastname: Deng
authors.forename: S H
authors.initials: SH
authors.lastname: Zhu
authors.forename: W D
authors.initials: WD
authors.lastname: Le
authors.forename: H R
authors.initials: HR
authors.lastname: Yang
authors.forename: H W
authors.initials: HW
authors.lastname: Lv
authors.forename: H B
authors.initials: HB
authors.lastname: Xu
authors.forename: W J
authors.initials: WJ
authors.lastname: Xie
authors.forename: J
authors.initials: J
authors.lastname: Jankovic
mesh_terms: D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006801:Humans; D051957:MSX1 Transcription Factor / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010300:Parkinson Disease / Q000175:diagnosis / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D051957:MSX1 Transcription Factor