Structural determination of prunusins A and B, new C-alkylated flavonoids from Prunus domestica, by 1D and 2D NMR spectroscopy.
Prunusins A (1) and B (2), the new C-alkylated flavonoids, have been isolated from the seed kernels of Prunus domestica. Their structures were assigned from (1)H and (13)C nuclear magnetic resonating spectra, DEPT and by correlation spectroscopy, HMQC and HMBC experiments. 3, 5, 7, 4'-Tetrahydroxyflavone (3) and 3, 5, 7-trihydroxy-8, 4'-dimethoxyflavone (4) have also been reported from this species. Both compounds (1) and (2) showed significant antifungal activity against pathogenic fungus Trichophyton simmi.
Mahmood
Azhar
A
PNEC National University of Sciences and Technology, Karachi-75270, Pakistan.
Fatima
Itrat
I
Kosar
Shaheen
S
Ahmed
Rehana
R
Malik
Abdul
A
D000478:Alkylation; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification; D003903:Deuterium; D047309:Flavones / Q000737:chemistry* / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D027861:Prunus / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
C548362:2-(4-(((3-ethylheptanoyl)oxy)methyl)phenyl)-5,8-dimethoxy-4-oxo-4H-chromen-7-yl 4-methylbenzoate; C548361:2-(4-(((3-ethylheptanoyl)oxy)methyl)phenyl)-5-methoxy-4-oxo-4H-chromen-7-yl 3-(4-methoxyphenyl)-2-propenoate; D000935:Antifungal Agents; D047309:Flavones; D005419:Flavonoids; D003903:Deuterium