Identification and quantitation of 3,4-methylenedioxy-N-methylamphetamine (MDMA, ecstasy) in human urine by 1H NMR spectroscopy. Application to five cases of intoxication.
Identification of 3,4-methylenedioxy-N-methylamphetamine (MDMA, ecstasy) in five cases of intoxication using nuclear magnetic resonance (NMR) spectroscopy of human urine is reported. A new water suppression technique PURGE (Presaturation Utilizing Relaxation Gradients and Echoes) was used. A calibration curve was obtained using spiked samples. The method gave a linear response (correlation coefficient of 0.992) over the range 0.01-1mg/mL. Subsequently, quantitation of the amount of MDMA present in the samples was performed. The benefit and reliability of NMR investigations of human urine for cases of intoxication with MDMA are discussed.
Liu
Jonathan
J
Department of Science, John Jay College of Criminal Justice, City University of New York, New York, NY 10019, USA.
Decatur
John
J
Proni
Gloria
G
Champeil
Elise
E
D053593:Forensic Toxicology; D006213:Hallucinogens / Q000652:urine*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000652:urine*; D011522:Protons; D015813:Substance Abuse Detection / Q000379:methods
D006213:Hallucinogens; D011522:Protons; D018817:N-Methyl-3,4-methylenedioxyamphetamine