title: Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs.
abstract: As part of ongoing studies in developing new antimicrobials, a class of structurally novel 4-thiazolidinone derivatives incorporating three known bioactive nuclei such as thiazole, thiazolidinone and adamantane was synthesized by the multi-step reaction protocol, already reported in the literature. NMR and Molecular Modeling techniques were employed for structure elucidation and Z/E potential isomerism configuration of the analogues. Evaluation of antibacterial and antifungal activity showed that almost all compounds exhibited better results than reference drugs thus they could be promising candidates for novel drugs.
authors.affiliation: Department of Pharmaceutical Chemistry of Aristotle, School of Pharmacy, University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Kouatli
authors.initials: K
authors.lastname: Omar
authors.forename: Athina
authors.initials: A
authors.lastname: Geronikaki
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Zoumpoulakis
authors.forename: Charalabos
authors.initials: C
authors.lastname: Camoutsis
authors.forename: Marina
authors.initials: M
authors.lastname: Soković
authors.forename: Ana
authors.initials: A
authors.lastname: Cirić
authors.forename: Jasmina
authors.initials: J
authors.lastname: Glamoclija
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007536:Isomerism; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013844:Thiazoles