Looking for the ideal particle: an experimental embolization study.
This study sought to compare the most frequently used embolic particles in an animal model. In 16 New Zealand white rabbits, right renal arteries were embolized using four different embolic particles (polyvinyl alcohol [PVA] particles, 150-250 microm; PVA microspheres [PVAMs], 150-300 microm; Tris-acryl gelatin microspheres [TGMs], 100-300 microm; expanding microspheres [EXMs], 50-100 microm). Quantity of embolic material used, embolization time, and angiographic patterns were documented. Fourteen days later, a control angiography was done to document angiographic recanalization and all animals were sacrificed. Histopathological specimens were analyzed for microscopic appearance and granulometric size of the particles, extravasation of the particles, perivascular inflammation, and neocapillarization. The volume of the infarct area in each kidney was calculated. Results revealed a significantly lesser amount of embolic material used in the EXM group (p = 0.020). The angiographic recanalization rate in the EXM group (100%), compared with the PVA (0%) and TGM (0%) groups, was found to be statistically significant (p = 0.014). Although 75% of the renal arteries embolized with PVAMs were recanalized, this was not found to be statistically significant (p = 0.071). Occlusion levels in the PVA group were more proximal than with any of the microspheres. While there was no extravasation in the TGM group, extravasation rates in the PVA, PVAM, and EXM groups were 50%, 25%, and 75%, respectively. A mild degree of inflammation was noted in the PVA, PVAM, and TGM groups. EXMs caused a moderate degree of inflammation in two kidneys (50%). There was neocapillarization in the vessel lumen in all kidneys in the PVA and PVAM groups. The difference was significant (p = 0.014) compared with the TGM and EXM groups, which did not have any neocapillarization. Regarding infarct area volumes, the difference among the groups was significant (p = 0.022). EXMs caused significantly (p = 0.021) less infarction than the other embolic agents. We conclude that EXMs are less efficient due to a high recanalization rate and lesser volume of infarct compared with the other embolic agents in the rabbit kidney model. The most efficient embolization was seen in kidneys embolized with TGMs.
Senturk
Cagin
C
Endovascular and Percutaneous Therapy Service, Hospital Ntra. Señora del Rosario, Madrid, Spain. caginsenturk@yahoo.com
Cakir
Volkan
V
Yorukoglu
Kutsal
K
Yilmaz
Osman
O
Goktay
A Yigit
AY
D000180:Acrylic Resins / Q000494:pharmacology*; D000792:Angiography; D000818:Animals; D001707:Biopsy, Needle; D004195:Disease Models, Animal; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000379:methods*; D005780:Gelatin / Q000494:pharmacology*; D007150:Immunohistochemistry; D007668:Kidney / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology*; D010316:Particle Size; D011142:Polyvinyl Alcohol / Q000494:pharmacology*; D011336:Probability; D011817:Rabbits; D011897:Random Allocation; D012077:Renal Artery; D012307:Risk Factors; D018709:Statistics, Nonparametric
D000180:Acrylic Resins; C496735:trisacryl gelatin microspheres; D005780:Gelatin; D011142:Polyvinyl Alcohol