title: Acting out of character: regulatory roles of nuclear pore complex proteins.
abstract: Nuclear pore complexes (NPCs) mediate all selective bidirectional transport between the nucleus and the cytoplasm. Additional functions for NPCs and their constituent proteins (nucleoporins) are emerging, some independent of classical transport. Specifically, enzymatic activities at the NPC regulate nucleocytoplasmic transport and use the NPC as a regulatory scaffold. Also, nucleoporins may regulate gene expression by contacting chromatin. Discriminating between effects on transport, scaffolding, and gene expression is a major challenge in understanding the role of the NPC in signaling and development.
authors.affiliation: Division of Gene Regulation, Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands.
authors.forename: Nikos
authors.initials: N
authors.lastname: Xylourgidis
authors.forename: Maarten
authors.initials: M
authors.lastname: Fornerod
mesh_terms: D000818:Animals; D001692:Biological Transport; D002467:Cell Nucleus / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism* / Q000648:ultrastructure; D015398:Signal Transduction
chemical_list: D028861:Nuclear Pore Complex Proteins