title: Amelioration of penile fibrosis: myth or reality.
abstract: Several changes have been reported to occur in the cavernosal tissue and tunica albuginea with aging. The atherosclerosis of the penis that occurs with aging causes a decrease in penile oxygen tension. A reduction in the number of smooth muscle cells (SMCs) has been demonstrated in relation to this change in oxygen tension. Changes in the ratio of penile collagen have also been observed and could explain the decrease in penile elasticity and compliance with aging. Chronic ischemia is therefore associated with fibrosis but also with nitric oxide-cGMP reduction. The sensitivity of the α-adrenoceptors on the SMCs increases with aging. Furthermore, androgen deprivation produces penile tissue atrophy, alterations in dorsal nerve structure, alterations in endothelial morphology, reductions in trabecular SM content, increases in deposition of extracellular matrix, and increases in accumulation of adipocytes in the subtunical region of the corpus cavernosum. All of these modifications can explain the prevalence of erectile dysfunction with aging. The aim of this review is to address the underlying etiology of corporal fibrosis, especially aging, cavernosal nerve damage, androgen deprivation, and tunical fibrosis. Finally, we will address the proposed amelioration and reversal of fibrosis in terms of correcting, at least partially, the relative SMC loss that occurs with aging, diabetes, or cavernosal nerve damage and its impact on prevention of erectile dysfunction-associated cavernosal fibrosis.
authors.affiliation: Department of Urology, Suez Canal University, Ismailia, Egypt. aielsakka@yahoo.com
authors.forename: Ahmed I
authors.initials: AI
authors.lastname: El-Sakka
authors.forename: Aksam A
authors.initials: AA
authors.lastname: Yassin
mesh_terms: D000375:Aging; D000728:Androgens / Q000172:deficiency; D000818:Animals; D003920:Diabetes Mellitus / Q000473:pathology; D005355:Fibrosis; D006801:Humans; D008297:Male; D010411:Penile Induration / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D010413:Penis / Q000473:pathology*
chemical_list: D000728:Androgens