Patterns of leukocyte counts on admissions for acute heart failure--presentation and outcome--results from a community based registry.
OBJECTIVE
To determine the correlation between differential white blood cell (WBC) count and characteristics and outcome of acute heart failure (AHF) syndromes.


BACKGROUND
Previous studies suggested that different white blood cell count patterns are related to outcome in patients with heart failure (HF) and other cardiovascular disorders.


METHODS
Data from all qualifying AHF admissions to a city hospital (n=340) was prospectively collected. Patients were followed from admission up to 6 months post-discharge. The relationship between patients' demographics, clinical and laboratory characteristics and outcome were assessed in relation to WBC count and lymphocyte to WBC ratio (LWR).


RESULTS
WBC count >10,100×10 (9)/L (upper tertile) on admission was associated with higher admission blood pressure, lower oxygen saturation, higher heart rate and increased troponin, with no impact on either short-term worsening HF or long-term adverse outcome. Lower LWR was associated with higher BUN and troponin and lower hemoglobin, but not with a distinct clinical presentation. The lower LWR tertile (≤13%) was associated with a 60% increase in worsening HF risk and a substantially higher 1 month (15% versus 2%) and 6 months mortality (23% vs. 3%) for lowest versus highest quartile (p<0.0001).


CONCLUSIONS
While increased WBC count is associated with a more "vascular presentation" and certain severity markers, it is not related to worse patient outcome. Low LWR (≤13%) is predictive of worse outcome and higher mortality. It is also associated with certain laboratory abnormalities, but not related to a specific clinical profile.
Milo-Cotter
Olga
O
Momentum Research Inc., Durham, North Carolina 27707, USA. olgacotter@momentum-research.com
Felker
G Michael
GM
Uriel
Nir
N
Kaluski
Edo
E
Edwards
Christopher
C
Rund
Michele M
MM
Weatherley
Beth Davison
BD
Cotter
Gad
G
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007958:Leukocyte Count / Q000379:methods / Q000592:standards; D008297:Male; D008875:Middle Aged; D010343:Patient Admission / Q000592:standards; D011446:Prospective Studies; D012042:Registries; D012111:Residence Characteristics; D016896:Treatment Outcome