title: Role of genetic polymorphism of estrogen receptor-alpha gene and risk of prostate cancer in north Indian population.
abstract: Present study depicted the role of polymorphisms in estrogen receptor-alpha gene in association with prostate cancer in north Indian population. The study was performed on 157 cases of prostate cancer, 170 cases of BPH, and 170 healthy Indian males diagnosed with prostate cancer and benign prostatic hyperplasia (BPH) and healthy males as controls. Determination of polymorphism in the ER-alpha gene was done by polymerase chain reaction followed by restriction fragment length polymorphism (RFLP) analysis with PvuII and XbaI enzymes. An association was observed between PvuII polymorphism of ER-alpha gene and that of prostate cancer. However, there was no such association with XbaI polymorphism in ER-alpha gene.
authors.affiliation: Department of Biotechnology, Panjab University, Chandigarh 160014, India. lgupta65@gmail.com
authors.forename: Lipsy
authors.initials: L
authors.lastname: Gupta
authors.forename: Hitender
authors.initials: H
authors.lastname: Thakur
authors.forename: Ranbir C
authors.initials: RC
authors.lastname: Sobti
authors.forename: Amlesh
authors.initials: A
authors.lastname: Seth
authors.forename: Sharwan K
authors.initials: SK
authors.lastname: Singh
mesh_terms: D000368:Aged; D047628:Estrogen Receptor alpha / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism
chemical_list: D047628:Estrogen Receptor alpha