title: Effective desensitization to imiglucerase in a patient with type I Gaucher disease.
abstract: We describe a child who had anaphylactic hypersensitivity to imiglucerase therapy for Gaucher disease. Treatment was stopped and symptoms returned. After immune desensitization to imiglucerase using a rush protocol, the patient was able to resume treatment and has not had further hypersensitivity complications to date.
authors.affiliation: Department of Pediatrics, University of Verona, Verona, Italy. peroni.diego@tiscalinet.it
authors.forename: Diego G
authors.initials: DG
authors.lastname: Peroni
authors.forename: Lydia
authors.initials: L
authors.lastname: Pescollderungg
authors.forename: Giorgio L
authors.initials: GL
authors.lastname: Piacentini
authors.forename: Walburga
authors.initials: W
authors.lastname: Cassar
authors.forename: Attilio L
authors.initials: AL
authors.lastname: Boner
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy*; D002648:Child; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D005776:Gaucher Disease / Q000188:drug therapy* / Q000276:immunology; D005962:Glucosylceramidase / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008297:Male
chemical_list: D005962:Glucosylceramidase; C090568:imiglucerase