title: Chemical constituents from Clematis delavayi var. spinescens.
abstract: A new coumarin, 7-hydroxy-4,6-dimethoxy-5-methylcoumarin (1), was isolated from the aerial parts of Clematis delavayi var. spinescens together with 17 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of all compounds were evaluated using a zebrafish model.
authors.affiliation: Laboratory of Ethnobotany, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China. liyang@mail.kib.ac.cn.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Si-Feng
authors.initials: SF
authors.lastname: Wang
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Zhao
authors.forename: Ke-Chun
authors.initials: KC
authors.lastname: Liu
authors.forename: Xi-Min
authors.initials: XM
authors.lastname: Wang
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Yang
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Li
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D000818:Animals; D039324:Clematis / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010793:Phthalazines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D015027:Zebrafish
chemical_list: D020533:Angiogenesis Inhibitors; D003374:Coumarins; D010793:Phthalazines; D011725:Pyridines; C404768:vatalanib; C030123:coumarin