title: [Wheat-dependent, exercise-induced anaphylaxis].
abstract: Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a rare IgE-dependent anaphylaxis to wheat, which occurs in sensitized people after ingestion of wheat followed by physical exercise. The major allergen associated with WDEIA is the wheat protein Omega (omega)-5-Gliadin (Tri a 19). We present three cases of WDEIA, demonstrating that this disease might be more frequent than anticipated and that neither prick test nor specific IgE to allergen extracts but rather detection of specific IgE against the recombinant protein Tri a 19 leads to diagnosis.
authors.affiliation: Klinik für Allergologie und Dermatologie, Universitätsklinikum RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland. rbrans@ukaachen.de
authors.forename: R
authors.initials: R
authors.lastname: Brans
authors.forename: H
authors.initials: H
authors.lastname: Ott
authors.forename: H F
authors.initials: HF
authors.lastname: Merk
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D000918:Antibody Specificity / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D015444:Exercise; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007428:Intradermal Tests; D008297:Male; D008875:Middle Aged; D014908:Triticum / Q000009:adverse effects* / Q000276:immunology; D053802:Tryptases / Q000097:blood; D014581:Urticaria / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology
chemical_list: D000939:Epitopes; D007073:Immunoglobulin E; D053802:Tryptases