title: Body weight variation and control of cardiovascular risk factors in essential hypertension.
abstract: OBJECTIVE
  The objective was to assess the impact of weight changes on blood pressure (BP), lipids and glucose goals in a cohort of hypertensive subjects.
  
  
  METHODS
  Prospective follow-up.
  
  
  METHODS
  Hypertension clinic.
  
  
  METHODS
  326 hypertensive non-diabetic subjects, 46% with metabolic syndrome (MS).
  
  
  METHODS
  Usual care treatment, which included diet, physical exercise and drugs prescribed when indicated. All patients were observed for up to 1 year.
  
  
  METHODS
  BP and low-density lipoprotein-cholesterol (LDL-C) goal were those in ESH/ESC and ATP III recommendations, respectively. The glucose goal was to delay progression to type 2 diabetes mellitus, or to achieve blood glucose <100 mg/dl for non-diabetics. According to body weight changes, patients were categorized using adjusted ROC curves models.
  
  
  RESULTS
  Overall, there was a significant weight increment of 0.5 kg (95% CI 0.1-0.9 kg); 28 patients (8.6%) lost more than 5 kg, and only four (1.2%) lost more than 10 kg. BP, LDL-C and glucose goals were achieved in 56%, 78% and 61% of patients, respectively. To lose or not gain weight was an independent prognostic factor to achieve the BP goal in all the patients and the LDL goal in the presence of MS. For glucose control, being treated with beta-blockers and/or diuretics was a negative factor.
  
  
  CONCLUSIONS
  In hypertensive subjects, even small changes in weight may have an important impact on achieving cardiovascular goals, mainly in those with MS.
authors.affiliation: Unidad de Hipertensión, Medicina Interna, Hospital de Sagunto, Agencia Valenciana de Salud, Sagunto, Spain.
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Pascual
authors.forename: Enrique
authors.initials: E
authors.lastname: Rodilla
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Costa
authors.forename: Francisco
authors.initials: F
authors.lastname: Perez-Lahiguera
authors.forename: Carmen
authors.initials: C
authors.lastname: Gonzalez
authors.forename: Empar
authors.initials: E
authors.lastname: Lurbe
authors.forename: Josep
authors.initials: J
authors.lastname: Redón
mesh_terms: D000328:Adult; D001786:Blood Glucose; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D015331:Cohort Studies; D004032:Diet; D005081:Exercise Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D015430:Weight Gain / Q000502:physiology*; D015431:Weight Loss / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D008055:Lipids