title: Comparison of arc-modulated cone beam therapy and helical tomotherapy for three different types of cancer.
abstract: OBJECTIVE
  Arc-modulated cone beam therapy (AMCBT) is a fast treatment technique deliverable in a single rotation with a conventional C-arm shaped linac. In this planning study, the authors assess the dosimetric properties of single-arc therapy in comparison to helical tomotherapy for three different tumor types.
  
  
  METHODS
  Treatment plans for three patients with prostate carcinoma, three patients with anal cancer, and three patients with head and neck cancer were optimized for helical tomotherapy and AMCBT. The dosimetric comparison of the two techniques is based on physical quantities derived from dose-volume histograms.
  
  
  RESULTS
  For prostate cancer, the quality of dose distributions calculated for AMCBT was of equal quality as that generated for tomotherapy with the additional benefits of a faster delivery and a lower integral dose. For highly complex geometries, the plan quality achievable with helical tomotherapy could not be achieved with arc-modulated cone beam therapy.
  
  
  CONCLUSIONS
  Rotation therapy with a conventional linac in a single arc is capable to deliver a high and homogeneous dose to the target and spare organs at risk. Advantages of this technique are a fast treatment time and a lower integral dose in comparison to helical tomotherapy. For highly complex cases, e.g., with several target regions, the dose shaping capabilities of AMCBT are inferior to those of tomotherapy. However, treatment plans for AMCBT were also clinically acceptable.
authors.affiliation: Department of Medical Physics in Radiation Therapy, German Cancer Research Center, Heidelberg 69120, Germany. s.ulrich@dkfz.de
authors.forename: Silke
authors.initials: S
authors.lastname: Ulrich
authors.forename: Florian
authors.initials: F
authors.lastname: Sterzing
authors.forename: Simeon
authors.initials: S
authors.lastname: Nill
authors.forename: Kai
authors.initials: K
authors.lastname: Schubert
authors.forename: Klaus K
authors.initials: KK
authors.lastname: Herfarth
authors.forename: Jürgen
authors.initials: J
authors.lastname: Debus
authors.forename: Uwe
authors.initials: U
authors.lastname: Oelfke
mesh_terms: D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000145:classification / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome