Effects of N-butyl-2-cyanoacrylate on high-level jejunojejunostomy.
BACKGROUND
Morbidity and mortality due to anastomotic complications in gastrointestinal surgery remain important problems. The tissue adhesive N-butyl-2-cyanoacrylate (NB2CA) is used in many fields of surgery. This study was designed to assess the effects of NB2CA on high-level jejunojejunostomy.


METHODS
Forty male albino Wistar rats were divided into 4 groups of 10 each. The groups were treated as follows: group 1 underwent only a jejunojejunostomy, group 2 underwent jejunojejunostomy followed by NB2CA application around the anastomosis, group 3 underwent jejunojejunostomy after a 60-min ischemia and a 60-min reperfusion, and group 4 underwent jejunojejunostomy after a 60-min ischemia and a 60-min reperfusion followed by NB2CA application around the anastomosis. At postoperative day 7, the subjects in all groups were sacrificed. Intra-abdominal adhesions, anastomotic complications and anastomotic burst pressures (ABP) were recorded.


RESULTS
The analysis of all the groups for adhesion scores and ABP showed statistical significance (p < 0.001).


CONCLUSIONS
The use of NB2CA had positive effects in terms of increasing ABP both with and without the initial ischemia- reperfusion insult. However, it had the adverse effect of significantly increasing the number of intra-abdominal adhesions.
Ensari
C O
CO
Department of Surgery, Ankara University Medical School, Ankara, Turkey.
Genc
V
V
Cakmak
A
A
Erkek
B
B
Karayalcin
K
K
D000714:Anastomosis, Surgical; D000818:Animals; D004659:Enbucrilate / Q000627:therapeutic use*; D007583:Jejunum / Q000601:surgery*; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000517:prevention & control*
D004659:Enbucrilate