Preparation of MPEG-PLA nanoparticle for honokiol delivery in vitro.
Honokiol (HK) shows potential application in cancer treatment, but its poor water solubility restricts clinical application greatly. In this paper, monomethoxy poly(ethylene glycol)-poly(lactic acid) (MPEG-PLA) was synthesized by ring-opening polymerization and processed into nanoparticle for honokiol delivery. Chemical structure of the synthesized polymer was confirmed by (1)H NMR, and its molecular weight was determined by gel permeation chromatography (GPC). Honokiol loaded MPEG-PLA nanoparticles were prepared by solvent extract method. And particle size distribution, morphology, drug loading, drug release profile and anticancer activity in vitro were studied in detail. The described honokiol loaded MPEG-PLA nanoparticles in this paper might be a novel formulation for honokiol delivery.
Zheng
XiuLing
X
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China.
Kan
Bing
B
Gou
MaLing
M
Fu
ShaoZhi
S
Zhang
Juan
J
Men
Ke
K
Chen
LiJuan
L
Luo
Feng
F
Zhao
YingLan
Y
Zhao
Xia
X
Wei
YuQuan
Y
Qian
ZhiYong
Z
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D002850:Chromatography, Gel; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D005260:Female; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D017705:Lignans / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D008970:Molecular Weight; D053758:Nanoparticles; D036103:Nanotechnology; D010051:Ovarian Neoplasms / Q000473:pathology; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry* / Q000633:toxicity; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000633:toxicity; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods; D000498:Allyl Compounds; D010636:Phenols
D000972:Antineoplastic Agents, Phytogenic; D001713:Biphenyl Compounds; D004337:Drug Carriers; D017705:Lignans; D011091:Polyesters; D011092:Polyethylene Glycols; D012997:Solvents; C492425:methoxy poly(ethylene glycol)-poly(lactide); C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols