title: Stepwise sequential screening for trisomy 21 in assisted reproduction pregnancies.
abstract: We offered a modified stepwise sequential integrated screening for Down syndrome to 72 singleton and 16 twin pregnancies obtained with assisted reproductive techniques, observing no cases of trisomy 21 and obtaining a false positive rate of 10% in singleton and 7% in twin pregnancies. In our population, this approach for regulating access to invasive karyotyping can avoid a substantial number of unnecessary procedures, comparing favourably with current practice even in spontaneous pregnancies.
authors.affiliation: U.O. Ostetricia e Ginecologia, Istituto G. Gaslini, Università di Genova, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Pastorino
authors.forename: Silvana
authors.initials: S
authors.lastname: Canini
authors.forename: Federico
authors.initials: F
authors.lastname: Prefumo
authors.forename: Davide
authors.initials: D
authors.lastname: Buffi
authors.forename: Monica
authors.initials: M
authors.lastname: Pugliese
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Venturini
authors.forename: Pierangela
authors.initials: P
authors.lastname: de Biasio
mesh_terms: D000328:Adult; D004314:Down Syndrome / Q000175:diagnosis*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged; D009098:Multiphasic Screening / Q000379:methods*; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011296:Prenatal Diagnosis / Q000379:methods*; D027724:Reproductive Techniques, Assisted