Lipoproteins, sex hormones and inflammatory markers in association with prostate cancer.
OBJECTIVE
To evaluate lipoprotein profile and sex hormones in patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH) and their possible associations with some inflammatory markers linked to PCa.


METHODS
A total of 150 men (50-65 years), matched by age and body mass index (BMI), included in this study and divided into three groups according to total prostate specific antigen (PSA), digital rectal examination and prostate biopsy: 50 PCa, 50 BPH and 50 controls. Total cholesterol (Chol), HDL-chol, LDL-chol, triglycerides (TG), total testosterone (T), free T (FT), bioavailable T (BioT), estradiol and SHBG were measured. The free androgen index (FAI) and TG/HDL-chol were calculated. In 25 PCa and 25 controls, C-reactive protein (hs-CRP), adiponectin and insulin were determined.


RESULTS
Patients with PCa showed higher TG/HDL-chol and diminished HDL-chol than Controls and BPH. PSA correlated inversely with HDL-chol and directly with TG/HDL-chol. FAI, FT, BioT and estradiol levels were higher, and SHBG and adiponectin were lower in PCa than in Controls. No differences were found in androgens between BPH and PCa.


CONCLUSIONS
Our most novel findings are that the patients with PCa presented lower total Chol and HDL-chol and higher TG/HDL-chol than BPH and Controls. Patients with PCa showed higher androgens and lower adiponectin than Controls.
Grosman
Halina
H
Clinical Biochemistry Department, INFIBIOC, Universidad de Buenos Aires, Argentina.
Fabre
Bibiana
B
Mesch
Viviana
V
Lopez
Miguel Angel
MA
Schreier
Laura
L
Mazza
Osvaldo
O
Berg
Gabriela
G
D052242:Adiponectin / Q000097:blood; D000368:Aged; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood*; D001706:Biopsy; D002097:C-Reactive Protein / Q000032:analysis*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004958:Estradiol / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood; D007328:Insulin / Q000097:blood; D016014:Linear Models; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D018709:Statistics, Nonparametric; D013739:Testosterone / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D052242:Adiponectin; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D008074:Lipoproteins; D012738:Sex Hormone-Binding Globulin; D014280:Triglycerides; D013739:Testosterone; D004958:Estradiol; D002097:C-Reactive Protein; D017430:Prostate-Specific Antigen