Audiological findings in patients treated with radio- and concomitant chemotherapy for head and neck tumors.
OBJECTIVE
To evaluate the functionality of the auditory system in patients who underwent radiotherapy and chemotherapy treatment with cisplatin to treat head and neck tumors.


METHODS
Case series with planned data collection.


METHODS
From May 2007 to May 2008 by the Department of Otorhinolaryngology and the Department of Oncology/Radiotherapy at Faculdade de Medicina de Marília.


METHODS
Audiological evaluation (Pure Tone Audiometry (air and bone conduction), Speech Audiometry, Tympanometry, Acoustic Reflex testing and Distortion Product Otoacoustic Emissions) was performed in 17 patients diagnosed with head and neck neoplasia and treated with chemotherapy, using cisplatin, and radiotherapy.


RESULTS
12 left ears (70.5%) and 11 right ears (64.7%) presented bilateral decreased hearing soon after the treatment for the frequency 1 kHz (mild auditory damage) and for the frequency 8 kHz (more significant auditory damage).


CONCLUSIONS
Patients with head and neck cancer submitted to the conventional radiotherapy treatment, combined with the chemotherapy with cisplatin, presented a high incidence of decreased hearing by the end of treatment. Strong evidence was observed linking auditory alteration to the amount of radiotherapy treatment.
Dell'Aringa
Ana Helena B
AH
Departament of Otorhinolaryngology of FAMEMA's General Hospital, Marília, Sao Paulo, Brazil. anahelenadell@yahoo.com.br
Isaac
Myrian L
ML
Arruda
Gustavo V
GV
Esteves
Maria Carolina B N
MC
Dell'aringa
Alfredo Rafael
AR
Júnior
José Luis S
JL
Rodrigues
Alexandre F
AF
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006311:Hearing Disorders / Q000209:etiology*; D006320:Hearing Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage
D000970:Antineoplastic Agents; D002945:Cisplatin