title: Enhanced resistance of DNA nanostructures to enzymatic digestion.
abstract: The ability of nucleases to perform their catalytic functions depends on the sequence and structural features of target DNA substrates. Due to their size and shape, several DNA tetrahedra are resistant to the action of specific and non-specific nucleases. Such enhanced stability is a key requirement for DNA nanostructures to be useful as delivery vehicles.
authors.affiliation: Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA.
authors.forename: Jung-Won
authors.initials: JW
authors.lastname: Keum
authors.forename: Harry
authors.initials: H
authors.lastname: Bermudez
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004262:DNA Restriction Enzymes / Q000378:metabolism*; D003850:Deoxyribonuclease I / Q000378:metabolism; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005090:Exodeoxyribonucleases / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry*; D009690:Nucleic Acid Conformation
chemical_list: D004247:DNA; D005090:Exodeoxyribonucleases; C020133:exodeoxyribonuclease III; D004262:DNA Restriction Enzymes; C027908:endodeoxyribonuclease DdeI; D003850:Deoxyribonuclease I; D015252:Deoxyribonucleases, Type II Site-Specific