title: Toward the total synthesis of goniodomin A, an actin-targeting marine polyether macrolide: convergent synthesis of the C15-C36 segment.
abstract: Stereoselective convergent synthesis of the C15-C36 segment of goniodomin A, an actin-targeting marine polyether macrolide natural product, has been achieved. The present synthesis features palladium(0)-catalyzed, copper(I)-mediated Liebeskind-Srogl cross-coupling as the fragment assembly process.
authors.affiliation: Graduate School of Life Sciences, Tohoku University, 1-1 Tsutsumidori-amamiya, Aoba-ku, Sendai 981-8555, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Saito
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Fuwa
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004987:Ethers; D018942:Macrolides; C059668:goniodomin A; D010165:Palladium; D003300:Copper