title: Micafungin concentrations from brain tissue and pancreatic pseudocyst fluid.
abstract: We report the attainment of micafungin concentrations from brain tissue and pancreatic pseudocyst fluid from two patients with invasive candidiasis. Micafungin was present in low levels at both body sites, indicating limited penetration into central nervous system (CNS) tissue and pancreatic fluid. Further studies are needed to fully characterize its pharmacokinetics at these locations, as micafungin may potentially serve as an alternative antifungal therapy for CNS or pancreatic candidal infections for which the currently recommended first-line therapy fails.
authors.affiliation: South Texas Veterans Affairs Health Care System, 4502 Medical Drive, San Antonio, TX 78229, USA.
authors.forename: Asma
authors.initials: A
authors.lastname: Lat
authors.forename: George R
authors.initials: GR
authors.lastname: Thompson
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rinaldi
authors.forename: Sheryl A
authors.initials: SA
authors.lastname: Dorsey
authors.forename: Gennethel
authors.initials: G
authors.lastname: Pennick
authors.forename: James S
authors.initials: JS
authors.lastname: Lewis
mesh_terms: D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism*; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D054714:Echinocandins / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D055666:Lipopeptides / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008297:Male; D000077551:Micafungin; D010192:Pancreatic Pseudocyst / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin