Bioactive caffeic acid esters from Glycyrrhiza glabra.
Thin layer chromatography bioautography (using DPPH spray reagent) guided fractionation of Glycyrrhiza glabra led to the isolation of two caffeic acid derivative esters, viz. eicosanyl caffeate (1) and docosyl caffeate (2). The two compounds exhibited potent elastase inhibitory activity, with IC(50) values of 0.99 microg mL(-1) and 1.4 microg mL(-1) for 1 and 2, respectively. The compounds also showed moderate antioxidant activity in DPPH and ABTS scavenging assays. The results indicate a possible role of caffeic acid derivatives, in addition to flavonoids in the anti-ulcer properties of G. glabra.
Dey
Surajit
S
R&D Centre, Natural Remedies Pvt. Ltd., Bangalore, India.
Deepak
Mundkinajeddu
M
Setty
Manjunath
M
D'Souza
Prashanth
P
Agarwal
Amit
A
Sangli
Gopal Krishna
GK
D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D002109:Caffeic Acids / Q000737:chemistry*; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D004952:Esters / Q000737:chemistry* / Q000494:pharmacology*; D006035:Glycyrrhiza / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology
D000975:Antioxidants; D002109:Caffeic Acids; D004791:Enzyme Inhibitors; D004952:Esters; D010936:Plant Extracts; D010196:Pancreatic Elastase; C040048:caffeic acid