Bilateral regulatory action of corticotropin-releasing hormone on immune-mediated inflammation.
In trauma, infection and hemorrhagic shock derived stress, primary and secondary injury may result in severe derangement in the internal environment. The abnormal changes of immune-mediated inflammation interfere its pathogenesis and development directly. In recent years, various aspects of neuroendocrine responses, especially the regulatory effects of hypothalamic-pituitary-adrenal and sympathetico-adrenomedullary axes in inflammatory diseases have been the focus of research. Most importantly, corticotropin-releasing hormone (CRH) acts as a key player in the regulation of interactions between neuroendocrine and immunity both directly and indirectly. The paper summarized the recent development of CRH in the immune-mediated inflammation.
Yang
Ce
C
State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
Jiang
Jian-xin
JX
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000032:analysis / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000276:immunology
D003346:Corticotropin-Releasing Hormone