Discovery of hydrolytic catalysts in a peptidocalixarene library by binding assay with a transition state analogue for the hydrolysis.
Hydrolytic catalysts were found in a peptidocalixarene library by binding assay with a transition state analogue for the hydrolysis. The rate of the reaction can be specifically enhanced up to 50-fold in the presence of the discovered catalyst.
Hioki
Hideaki
H
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan. hioki@ph.bunri-u.ac.jp
Nishimoto
Ryosuke
R
Kawaguchi
Kota
K
Kubo
Miwa
M
Harada
Kenichi
K
Fukuyama
Yoshiyasu
Y
D001665:Binding Sites; D047250:Calixarenes / Q000737:chemistry*; D002384:Catalysis; D006868:Hydrolysis; D007700:Kinetics; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry*
D019151:Peptide Library; D010455:Peptides; D047250:Calixarenes