Role of the serotoninergic system in the development of diseases of the intestinal and biliferous tracts.
Primary sclerosing cholangitis and nonspecific ulcerative colitis were modeled before and after serotonin and spiperone injections. Activation of the serotoninergic system prevented the development of primary sclerosing cholangitis, but promoted more severe course of nonspecific ulcerative colitis.
Lychkova
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AE
Institute of Gastroenterology, Moscow. lychkova@mail.ru
D000818:Animals; D015209:Cholangitis, Sclerosing / Q000139:chemically induced / Q000503:physiopathology*; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000503:physiopathology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D018757:GABA Modulators / Q000494:pharmacology; D032389:Myocytes, Smooth Muscle / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism* / Q000494:pharmacology; D058830:Serotonin 5-HT2 Receptor Antagonists; D018490:Serotonin Agents / Q000494:pharmacology; D013134:Spiperone / Q000378:metabolism* / Q000494:pharmacology; D014302:Trinitrobenzenesulfonic Acid / Q000633:toxicity
D018492:Dopamine Antagonists; D018757:GABA Modulators; D058830:Serotonin 5-HT2 Receptor Antagonists; D018490:Serotonin Agents; D012701:Serotonin; D013134:Spiperone; D014302:Trinitrobenzenesulfonic Acid; D010424:Pentobarbital