title: Association between hyperuricemia and hypertension in a Chinese population at a high risk of hypertension.
abstract: In this cross-sectional study, we examined whether hyperuricemia is associated with hypertension and the association exists in a Chinese population at a high risk of hypertension. The study population included 813 consecutively clinical patients with suspected cardiovascular disease, including the subjects with the current use of antihypertensive medications and self-reported diagnosis of hypertension. The subjects underwent three measures of blood pressure and were divided into two groups: 502 non-hypertensive subjects and 311 hypertensive subjects. Clinical and biochemical variables were measured. Results showed that uric acid level, fasting glucose, low-density lipoprotein (LDL)-cholesterol, total cholesterol and urea nitrogen were significantly higher (all p<0.05) in hypertension subjects than in non-hypertension subjects. The risk of hypertension was significantly higher in the group with higher uric acid (>400 micromol/l), compared with that with lower uric acid (<200 micromol/l) (odds ratio: 2.09, 95% CI 1.13-3.88). The odds ratio was 1.73, 95% CI 1.05-2.85 in the higher uric acid (200-400 micromol/l) group, compared with that with lower uric acid. In addition, age, gender, weight, fasting glucose, triglycerides and total cholesterol were also significantly associated with the incidence of hypertension. In age-adjusted logistic regression analysis, the effect of uric acid concentration on hypertension was attenuated. In conclusion, hyperuricemia is associated with hypertension in a Chinese population at a high risk of hypertension.
authors.affiliation: Department of Orthopedic Surgery, Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.
authors.forename: Zhen Sui
authors.initials: ZS
authors.lastname: Lu
authors.forename: Zhen Hong
authors.initials: ZH
authors.lastname: Lu
authors.forename: Hang
authors.initials: H
authors.lastname: Lu
authors.forename: Shi Gui
authors.initials: SG
authors.lastname: Yan
authors.forename: Jian An
authors.initials: JA
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: You
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D001786:Blood Glucose; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology*; D033461:Hyperuricemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000652:urine; D012306:Risk; D014527:Uric Acid / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D014527:Uric Acid; D002784:Cholesterol; D009584:Nitrogen