Bacterial translocation in heat stroke.
The scientific community is fully aware of the importance of heat-related illness and heat stroke syndrome. Numerous guidelines have been recently published and most of them agree on the key role played by the intestine. Likewise, the role of endotoxinemia in the pathophysiology is well established. However, the possibility of bacterial translocation is not mentioned. Our patient illustrates the likelihood of bacterial translocation in heat stroke and consistently the potential need of antibiotic therapy. A 45-year-old man diagnosed with paranoid schizophrenia was confined in a penitentiary center. One summer day in which a temperature of 41 degrees C was observed in the shade, the patient was found in deep coma with an axillary temperature of 42 degrees C. Multiorgan failure was detected in the hospital. Other causes of coma and/or hyperthermia were excluded, and heat stroke was diagnosed. Blood cultures were positive for Pseudomonas aeruginosa and Escherichia coli. Infection site was not identified despite of an exhaustive search. The patient fully recovered after 48 hours. On the basis of review of the literature, we think that bacterial translocation can take part in the pathophysiology of heat stroke. Therefore, antibiotic treatment must be evaluated in heat stroke patients.
Ramírez
Paula
P
Intensive Care Unit, Hospital Universitario Fe, 46009 Valencia, Spain. ramirez_pau@gva.es
Martí
Verónica
V
de la Plata
Alberto Márquez
AM
Salinas
Gema
G
Bonastre
Juan
J
Ruano
Miguel
M
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D018988:Bacterial Translocation / Q000502:physiology*; D004926:Escherichia coli / Q000502:physiology*; D018883:Heat Stroke / Q000150:complications* / Q000382:microbiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011550:Pseudomonas aeruginosa / Q000502:physiology*
D000900:Anti-Bacterial Agents