Fluctuations of ionic current through lipid bilayers at the onset of peptide attacks and pore formation.
Voltage-clamp measurements on lipid bilayers at the onset of peptide attacks before pore formation are reported. With four different peptides [alamethicin, melittin, and two synthetic peptides of the leucine (L)-lysine(K) copolymers (LK series)], correlations of conductivity fluctuations slowly decay over four decades in time. This slow dynamics is interpreted as being due to fluctuations of peptide concentration at the crowded surface of the bilayer and found to be compatible with the t(-1/2) relaxation of the RSA model.
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Université Paris 13, UFR SMBH, 93017 Bobigny cedex and Laboratoire Léon Brillouin, CEA/CNRS UMR 12, CEA-Saclay, 91191 Gif-sur-Yvette cedex, France.
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