title: Ligands of diltiazem binding site: an overview of some chemotypes.
abstract: The diltiazem binding site of L-type calcium channels is the least characterized to date. In this paper, we present some of the available chemotypes that bind to the benzothiazepine binding site: natural compounds, compounds synthesized by varying the benzothiazepine scaffold, and compounds discovered by means of computational approaches.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università degli Studi di Bologna, Via Belmeloro 6, 40126 Bologna, Italia. roberta.budriesi@unibo.it
authors.forename: R
authors.initials: R
authors.lastname: Budriesi
authors.forename: P
authors.initials: P
authors.lastname: Ioan
authors.forename: E
authors.initials: E
authors.lastname: Carosati
authors.forename: G
authors.initials: G
authors.lastname: Cruciani
authors.forename: B S
authors.initials: BS
authors.lastname: Zhorov
authors.forename: A
authors.initials: A
authors.lastname: Chiarini
mesh_terms: D001665:Binding Sites; D002121:Calcium Channel Blockers / Q000737:chemistry*; D020746:Calcium Channels, L-Type / Q000737:chemistry / Q000378:metabolism; D003198:Computer Simulation; D004110:Diltiazem / Q000031:analogs & derivatives* / Q000737:chemistry; D008024:Ligands
chemical_list: D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D008024:Ligands; D004110:Diltiazem