A stereoselective approach to nucleosides and 4'-thioanalogues from acyclic precursors.
D- and L-nucleosides and analogues thereof, including the 4'-thionucleoside series, are one of the most important biological and pharmaceutically active classes of compounds. A novel approach to their synthesis from chiral acyclic thioaminal, bearing the nucleobase, is described.
Chapdelaine
Daniel
D
Institut de recherches cliniques de Montréal, Bio-organic Chemistry Laboratory, 110 avenue des Pins Ouest, Montréal, Québec, Canada H2W 1R7.
Cardinal-David
Benoit
B
Prévost
Michel
M
Gagnon
Marc
M
Thumin
Isabelle
I
Guindon
Yvan
Y
D009705:Nucleosides / Q000737:chemistry*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D009705:Nucleosides; D013438:Sulfhydryl Compounds