War and peace between microbes: HIV-1 interactions with coinfecting viruses.
HIV-1 disrupts the homeostatic equilibrium between the host and coinfecting microbes, facilitating reactivation of persistent viruses and invasion by new viruses. These viruses usually accelerate HIV disease but occasionally create conditions detrimental for HIV-1. Understanding these phenomena may lead to anti-HIV-1 strategies that specifically target interactions between HIV-1 and coinfecting viruses.
Lisco
Andrea
A
Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Vanpouille
Christophe
C
Margolis
Leonid
L
D015897:Comorbidity; D015967:Gene Expression Regulation, Viral; D015658:HIV Infections / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000472:pathogenicity / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D014777:Virus Diseases / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D014779:Virus Replication; D014780:Viruses / Q000276:immunology / Q000472:pathogenicity