title: Feasibility and safety of transcatheter intervention for complex patent ductus arteriosus.
abstract: We evaluated the transcatheter intervention of complex patent ductus arteriosus (PDA) in Chinese adults. Between January 2004 and April 2008, 112 adult patients (43 males, 69 females, mean age 31 +/- 19 years) underwent intervention. Coils were used for patients with small PDA, and Amplatzer duct occluders or China-made mushroom-shaped occluders were used for patients with moderate-to-large PDA. The success rate of transcatheter intervention was 93.8%, and 9 patients (8.0%) had small residual shunts. At the end of 12 months follow-up, the rate of residual shunts was 1.8%. Peak systolic pulmonary pressure decreased from 94 +/- 21 mm Hg preintervention to 58 +/- 20 mm Hg postintervention (P < .001). No severe procedure-related complications (including death, dislocation of occluders, stenosis of aorta or pulmonary artery) occurred. Some patients developed hemolysis or vascular access complications, all resolved by conservative therapy. Transcatheter intervention is an effective and safe treatment for adult PDA patients with complex anatomic or hemodynamic conditions.
authors.affiliation: 12th Ward, Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Chao Yang District, Beijing, China.
authors.forename: Shi-Wei
authors.initials: SW
authors.lastname: Yang
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Zhou
authors.forename: Da-Yi
authors.initials: DY
authors.lastname: Hu
authors.forename: Yu-Yang
authors.initials: YY
authors.lastname: Liu
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Shi
authors.forename: Yong-He
authors.initials: YH
authors.lastname: Guo
authors.forename: Wan-Jun
authors.initials: WJ
authors.lastname: Cheng
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Nie
authors.forename: Jian-Long
authors.initials: JL
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D002648:Child; D002681:China; D015331:Cohort Studies; D004374:Ductus Arteriosus, Patent / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D011474:Prosthesis Design; D012189:Retrospective Studies; D055989:Septal Occluder Device; D016896:Treatment Outcome; D055815:Young Adult