D-cycloserine and early ethanol exposure in developing rats.
Pregnant rats were exposed to one of the following treatments: 20% aqueous sucrose (w/v; Control), 20% aqueous sucrose with 20 mg D-cycloserine (DCS), 20% aqueous sucrose with 5% ethanol (ETH), or 20% aqueous sucrose with both 20 mg DCS and 5% ethanol (DCS+ ETH). Treatments were delivered in 20 ml of drinking water provided daily, as pilot work had determined that this was the average daily water consumption for female rats. Treatments began on Day 10 or 11 of pregnancy and terminated on postnatal Day 10. As juveniles, offspring were tested for activity in an open field and motor coordination using a rotating rod. Ethanol and DCS+ Ethanol groups were the most active groups in the open field, and DCS and DCS+ Ethanol groups had fewer falls than the Control and Ethanol groups on the rod test. Results suggest that DCS might provide protection from ethanol's adverse effects on some developmental behaviors.
Isaac
W L
WL
Department of Psychology, Georgia College & State University, Milledgeville, GA 31061, USA. walter.isaac@gcsu.edu
McDaniel
W F
WF
Corley
J D
JD
Emard
S
S
McDonald
C
C
Young
L K
LK
Ray
C
C
D000818:Animals; D001921:Brain / Q000187:drug effects; D016572:Cyclosporine / Q000494:pharmacology*; D000431:Ethanol / Q000037:antagonists & inhibitors / Q000633:toxicity*; D005260:Female; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D009473:Neuronal Plasticity / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000523:psychology*; D011597:Psychomotor Performance / Q000187:drug effects*; D051381:Rats; D020318:Rats, Long-Evans
D007166:Immunosuppressive Agents; D000431:Ethanol; D016572:Cyclosporine