TRAF-mediated TNFR-family signaling.
The tumor necrosis factor (TNF) superfamily consists of a wide variety of cell-bound and secreted proteins that regulate numerous cellular processes. In particular, TNF-family proteins regulate the proliferation and death of tumor cells, as well as activated immune cells. This overview discusses the mammalian TNF receptor-associated factors (TRAFs), of which TRAF1, 2, 3, 5, and 6 have been shown to interact directly or indirectly with members of the TNF receptor superfamily. Structural features of TRAF proteins are described along with a discussion of TRAF-interacting proteins and the signaling pathways activated by the TRAF proteins. Finally, we examine the phenotypes observed in TRAF-knockout mice.
Ha
Hyunil
H
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Han
Daehee
D
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Choi
Yongwon
Y
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
D000818:Animals; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
D018124:Receptors, Tumor Necrosis Factor; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins