Psoriasis and alcohol: is cutaneous ethanol one of the missing links?
Many exogenous factors including excessive alcohol consumption have been associated with psoriasis, but the underlying mechanisms still remain elusive. Drinking worsens therapeutic compliance, and decreases the efficacy and increases the toxicity of systemic antipsoriatic treatments. Excess alcohol intake results in compromised immunity and increased risk of infections, but alcohol can induce proinflammatory cytokine production in various cell types and can increase mitogen-derived lymphocyte proliferation and lymphocyte activation. As we have previously reported, alcohol and one of its metabolites, acetone, induce keratinocyte proliferation and increase the mRNA levels of genes characteristic for proliferating keratinocytes, such as alpha5 integrin, cyclin D1 and keratinocyte growth factor receptor. Recently the correlation between blood and skin ethanol levels in humans was determined by a transdermal alcohol monitoring device, against the 'gold standard' breath alcohol readings. Based on transdermal alcohol measurements it can be concluded that cutaneous alcohol concentrations can reach levels that induce proinflammatory cytokine production and lymphocyte and keratinocyte proliferation in vitro. It is expected that the development of methodologies measuring transdermal ethanol will provide additional tools to evaluate how alcohol influences skin physiology and different dermatological conditions including psoriasis. Our review focuses on the possible link between alcohol misuse and psoriasis, particularly on the possible role of cutaneous ethanol in precipitating the disease.
Farkas
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Department of Dermatology and Allergology, University of Szeged, 6720 Szeged, Korányi fasor 6, Hungary. farkas@mail.derma.szote.u-szeged.hu
Kemény
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L
D051722:ADAM Proteins / Q000378:metabolism; D000072198:ADAM17 Protein; D000096:Acetone / Q000494:pharmacology; D000428:Alcohol Drinking / Q000009:adverse effects / Q000276:immunology; D000431:Ethanol / Q000032:analysis* / Q000494:pharmacology; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D011565:Psoriasis / Q000276:immunology*; D012867:Skin / Q000737:chemistry* / Q000187:drug effects; D012997:Solvents / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D012997:Solvents; D014409:Tumor Necrosis Factor-alpha; D000096:Acetone; D000431:Ethanol; D051722:ADAM Proteins; D000072198:ADAM17 Protein