Possible roles of IL-27 in the pathogenesis of psoriasis.
The immunological significance of IL-27 has been reported and discussed in various Th1/Th17-mediated inflammatory diseases. However, its importance in psoriasis is unknown. We investigated pathophysiological roles of IL-27 in psoriasis in this study. Serum IL-27 levels in psoriatic patients were significantly higher than those in healthy controls, and correlated with disease severity and serum IFN-gamma levels. An immunohistochemical analysis revealed the infiltration of IL-27-secreting cells in the papillary dermis of psoriatic skin lesions but not in skin lesions with atopic dermatitis or normal skin. Furthermore, IL-27 alone greatly induced in vitro CXCL9, CXCL10, and CXCL11 production and tyrosine phosphorylation of signal transducer and activator of transcription 1 in normal human keratinocytes, while it suppressed the tumor necrosis factor-alpha-induced production of IL-1alpha and CCL20. These results indicate that IL-27 may promote the onset of psoriasis, while it may simultaneously attenuate the expanded inflammation in this disease. Our results implicate potential therapeutic effects of IL-27 for psoriasis.
Shibata
Sayaka
S
Faculty of Medicine, Department of Dermatology, University of Tokyo, Tokyo, Japan. sayakashibata-tky@umin.ac.jp
Tada
Yayoi
Y
Kanda
Naoko
N
Nashiro
Kiyoko
K
Kamata
Masahiro
M
Karakawa
Masaru
M
Miyagaki
Tomomitsu
T
Kai
Hiromichi
H
Saeki
Hidehisa
H
Shirakata
Yuji
Y
Watanabe
Shinichi
S
Tamaki
Kunihiko
K
Sato
Shinichi
S
D000328:Adult; D002478:Cells, Cultured; D054418:Chemokine CCL20 / Q000378:metabolism; D054357:Chemokine CXCL10 / Q000378:metabolism; D054371:Chemokine CXCL11 / Q000378:metabolism; D054370:Chemokine CXCL9 / Q000378:metabolism; D020405:Dermis / Q000276:immunology / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007371:Interferon-gamma / Q000097:blood; D053582:Interleukin-1alpha / Q000378:metabolism; D007378:Interleukins / Q000097:blood* / Q000276:immunology*; D015603:Keratinocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation / Q000276:immunology; D011565:Psoriasis / Q000209:etiology / Q000276:immunology / Q000503:physiopathology; D012720:Severity of Illness Index; D015398:Signal Transduction / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D015854:Up-Regulation / Q000276:immunology
C108355:CCL20 protein, human; C114753:CXCL10 protein, human; C515202:CXCL11 protein, human; C080810:CXCL9 protein, human; D054418:Chemokine CCL20; D054357:Chemokine CXCL10; D054371:Chemokine CXCL11; D054370:Chemokine CXCL9; D053582:Interleukin-1alpha; D007378:Interleukins; C464565:MYDGF protein, human; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma