title: Peptide thioester synthesis through N-->S acyl-transfer: application to the synthesis of a beta-defensin.
abstract: Peptide thioesters readily prepared through N-->S acyl transfer of a specific C-terminal motif provide access to biologically active mini-proteins using native chemical ligation.
authors.affiliation: Department of Chemistry, University College London, 20 Gordon Street, London, UK WC1H 0AJ.
authors.forename: Jaskiranjit
authors.initials: J
authors.lastname: Kang
authors.forename: Natalie L
authors.initials: NL
authors.lastname: Reynolds
authors.forename: Christine
authors.initials: C
authors.lastname: Tyrrell
authors.forename: Julia R
authors.initials: JR
authors.lastname: Dorin
authors.forename: Derek
authors.initials: D
authors.lastname: Macmillan
mesh_terms: D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013997:Time Factors; D023083:beta-Defensins / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D004952:Esters; D013438:Sulfhydryl Compounds; D023083:beta-Defensins