Job strain and risk of esophageal and cardia cancers.
BACKGROUND
Few studies have investigated work-related stress in relation to esophageal or cardia cancers.


METHODS
Our nationwide Swedish population-based case-control study included 189 and 262 esophageal and cardia adenocarcinoma cases respectively, 167 esophageal squamous-cell carcinoma cases and 820 controls. We derived each study participant's occupation of longest duration from occupational histories and applied a psychosocial job-exposure matrix. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using conditional logistic regression, in multivariable models.


RESULTS
Job strain was positively associated with risk of esophageal adenocarcinoma (OR 3.2, 95% CI 1.0-9.8) and squamous-cell carcinoma (OR 4.0, 95% CI 1.6-10.5), but not with cardia adenocarcinoma. No associations regarding demands, control, social support or iso strain were observed, except for a positive association between high control and risk of esophageal squamous-cell carcinoma (OR 1.5, 95% CI 1.0-2.3).


CONCLUSIONS
Job strain seems to increase the risk of both histological types of esophageal cancer.
Jansson
Catarina
C
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Catarina.Jansson@ki.se
Jeding
Kerstin
K
Lagergren
Jesper
J
D000230:Adenocarcinoma / Q000453:epidemiology* / Q000523:psychology; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000523:psychology; D016022:Case-Control Studies; D015331:Cohort Studies; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000523:psychology; D013315:Stress, Psychological; D016526:Workload / Q000523:psychology*