[Crohn's disease, primary sclerosing cholangitis and antiphospholipid syndrome: an uncommon association].
BACKGROUND
Inflammatory bowel diseases are frequently associated with extra-intestinal manifestations and other autoimmune disorders. Association between primary sclerosing cholangitis and Crohn's disease is established. However, the association of antiphospholipid syndrome with Crohn's disease was reported in the literature only in the form of isolated case reports.


OBJECTIVE
To report a Tunisian case of association of Crohn's disease, primary sclerosing cholangitis and antiphospholipid syndrome.


METHODS
We report the case of a patient presenting a colonic Crohn's disease associated with primary sclerosing cholangitis and antiphospholipid syndrome. Sclerosing cholangitis was diagnosed basing on disturbances of the hepatic biochemical tests. Antiphospholipid syndrome was revealed by a venous thrombosis of the lower limbs.


CONCLUSIONS
Although the anticardiolipin antibodies were frequently found during the course of primary sclerosing cholangitis, the association with antiphospholipid syndrome is exceptionally described. In the same way, triple association of primary sclerosing cholangitis, Crohn's disease and antiphospholipid syndrome was not brought back in the literature.
Romdhane
Hayfa
H
Service de Gastroentérologie A, Hôpital la Rabta, Tunis.
Karoui
Sami
S
Serghini
Meriem
M
Boubaker
Jalel
J
Filali
Azza
A
D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications*; D015209:Cholangitis, Sclerosing / Q000150:complications*; D003424:Crohn Disease / Q000150:complications*; D006801:Humans; D008297:Male