Study on the different expression of molecular markers between cardiac cancer and distal gastric cancer and their correlations with clinicopathological features.
OBJECTIVE
Currently, few studies have reported the different expression of molecular markers between distal gastric cancer and cardiac cancer. Here, we sought to make an investigation about it by a retrospective analysis.


METHODS
The expression of 8 proteins, including epidermal growth factor receptor, glutathione S-transferase pi (GST-pi), cyclin D1, Neu/Her-2, C-myc, p53, p27 and p21, were evaluated in 110 cases with cardiac cancer and 101 cases with distal gastric cancer who underwent curative surgery at the Cancer Hospital, Fudan University, in 2005 by immunohistochemistry method.


RESULTS
The TNM stage, differentiation grade, invasion depth and lymph node metastasis were significantly different between cardiac cancer and distal gastric cancer. p21 (p = 0.034), Neu (p = 0.017), and GST-pi (p = 0.003) were expressed in relatively higher levels in cardiac cancer than in distal gastric cancer. Furthermore, the clinical pathological parameters were significantly correlated with the expression of molecules mentioned above.


CONCLUSIONS
Different molecular mechanisms may be involved in the tumorigenesis and development of cardiac cancer and distal gastric cancer.
Ye
Yan-wei
YW
Department of Abdominal Surgery, Shanghai Medical College, Fudan University, Shanghai, China.
Fu
Hong
H
Zhou
Ye
Y
Du
Chun-yan
CY
Li
Bai-zhou
BZ
Zhu
Lei
L
Shi
Ying-qiang
YQ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002299:Cardia / Q000378:metabolism* / Q000473:pathology; D019938:Cyclin D1 / Q000378:metabolism; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D051549:Glutathione S-Transferase pi / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009439:Neuraminidase / Q000378:metabolism; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate; D014157:Transcription Factors / Q000378:metabolism; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D004268:DNA-Binding Proteins; C116115:MYCBP protein, human; D014157:Transcription Factors; D019938:Cyclin D1; D050760:Cyclin-Dependent Kinase Inhibitor p27; D051549:Glutathione S-Transferase pi; D066246:ErbB Receptors; C403285:NEU2 protein, human; D009439:Neuraminidase