title: Central neurological complications in critically ill patients with malignancies.
abstract: OBJECTIVE
  To determine outcomes in critically ill patients hospitalized in the ICU for central neurological complications of cancer.
  
  
  METHODS
  A 7-year retrospective study. SUBJECT AND INTERVENTION: Observational study in 100 critically ill cancer patients with central neurological complications managed using standardized diagnostic and therapeutic strategies.
  
  
  RESULTS
  There were 52 men and 48 women, aged 55 years (IQR, 40-65). Presenting manifestations were coma (56%), epilepsy (48%), focal signs (35%), encephalopathy (31%), and meningitis (7%). Cerebral imaging was abnormal in 61 patients, lumbar puncture in 17, and electroencephalography in 6. Neurosurgical biopsy was performed on four patients. The main etiologies included drug toxicity in 28, malignant brain infiltration in 21 patients, and cerebrovascular disease in 20. Mechanical ventilation was needed for 60 patients. Anticancer chemotherapy was administered during the ICU stay in 15 patients. ICU and hospital mortalities were 28 and 45%, respectively. By multivariate analysis, independent positive predictors of hospital mortality were poor performance status [odds ratio (OR) 2.94, 95% CI, 1.01-8.55, P = 0.047), focal signs at presentation (OR 3.52, 95% CI, 1.14-10.88, P = 0.029), abnormal lumbar puncture (OR 5.49, 95% CI 1.09-27.66, P = 0.038), and need for vasoactive drugs (OR 6.47, 95% CI 1.32-31.66, P = 0.021), whereas remission of the malignancy (OR 0.20, 95% CI 0.04-0.88, P = 0.033) and GCS score at admission (OR 0.81/point, 95% CI, 0.70-0.95, P = 0.009) were negative predictors of hospital mortality.
  
  
  CONCLUSIONS
  In cancer patients, central neurological events are mainly related to malignant brain infiltration and drug-related toxicity. Despite advanced severity, a standardized intensive management strategy yields a 55% hospital survival rate.
authors.affiliation: Medical Intensive Care Unit, AP-HP, Hôpital Saint-Louis, 75010 Paris, France. stlegriel@invivo.edu
authors.forename: Stéphane
authors.initials: S
authors.lastname: Legriel
authors.forename: Hélène
authors.initials: H
authors.lastname: Marijon
authors.forename: Michael
authors.initials: M
authors.lastname: Darmon
authors.forename: Virginie
authors.initials: V
authors.lastname: Lemiale
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bedos
authors.forename: Benoît
authors.initials: B
authors.lastname: Schlemmer
authors.forename: Elie
authors.initials: E
authors.lastname: Azoulay
mesh_terms: D000328:Adult; D000368:Aged; D003128:Coma / Q000175:diagnosis / Q000453:epidemiology*; D016638:Critical Illness; D004569:Electroencephalography; D005260:Female; D006760:Hospitalization; D006801:Humans; D002534:Hypoxia, Brain / Q000175:diagnosis / Q000453:epidemiology*; D007362:Intensive Care Units / Q000706:statistics & numerical data; D008297:Male; D008581:Meningitis / Q000453:epidemiology*; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000534:rehabilitation*; D012121:Respiration, Artificial; D013129:Spinal Puncture