title: Off-channel effect of high-frequency overstimulation on duration tuning of low-frequency inferior colliculus neurons in guinea pigs.
abstract: CONCLUSIONS
  High-frequency overstimulation can cause the loss of duration selectivity in low-frequency inferior colliculus neurons in guinea pigs.
  
  
  OBJECTIVE
  To investigate the effect of high-frequency overstimulation on duration tuning in low-frequency inferior colliculus neurons in guinea pigs.
  
  
  METHODS
  Duration tuning pattern was recorded by measuring the spikes of single neurons in response to the best frequency (BF) of different durations. The effect of high-frequency overstimulation was verified by comparing the responses before and after the tone exposure.
  
  
  RESULTS
  In total, 40 duration-tuned neurons were successfully recorded before and after the tone exposure. After the high-frequency tone trauma, a total of 29 neurons (72.5%) became non-duration-tuned.
authors.affiliation: Institute of Otolaryngology, Shanghai JiaoTong University, Shanghai, China.
authors.forename: Zhengnong
authors.initials: Z
authors.lastname: Chen
authors.forename: Dongzhen
authors.initials: D
authors.lastname: Yu
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Feng
authors.forename: Kaiming
authors.initials: K
authors.lastname: Su
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Shankai
authors.initials: S
authors.lastname: Yin
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology*; D007245:Inferior Colliculi / Q000166:cytology / Q000503:physiopathology*; D008297:Male; D009474:Neurons / Q000502:physiology