In situ, real-time tracking of cell wall topography and nanomechanics of antimycobacterial drugs treated Mycobacterium JLS using atomic force microscopy.
Two antimycobacterial drugs ethambutol (EMB) and isoniazid (INH) were found to result in decreases of biomechanical properties including adhesion force, cell wall spring constant, and Young's modulus in Mycobacterium sp. strain JLS (M. JLS).
Wu
Yangzhe
Y
Biological Engineering Program, Utah State University, 4105 Old Main Hill, Logan, Utah 84322-4105, USA.
Zhou
Anhong
A
D002455:Cell Division; D002473:Cell Wall / Q000737:chemistry* / Q000378:metabolism; D004977:Ethambutol / Q000737:chemistry*; D007538:Isoniazid / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D009161:Mycobacterium / Q000187:drug effects*; D010457:Peptidoglycan / Q000737:chemistry
D010457:Peptidoglycan; D004977:Ethambutol; D007538:Isoniazid