Tuning anti-microbial activity of poly(4-vinyl 2-hydroxyethyl pyridinium) chloride by anion exchange reactions.
A series of new bioactive polymers with pendant choline analogous group was prepared by anion exchange reaction direct at the quaternary nitrogen of the polycation. Poly(4-vinyl 2-hydroxyethyl pyridinium) chloride was prepared in situ by simultaneous polymerization and quaternization of 4-vinyl pyridine with 2-chloroethanol that also acts as catalyst. The counter anion (Cl(-)) of the polycation was exchanged by anion exchange reaction with Br(-), (-)OH, (-)SH, NO(3) (-), BF(4) (-) or CF(3)COO(-). Evidence of anion exchange was obtained by the characterization of the resultant polymers. The nature of the counter anion has profound effect on their properties including strong anion-dependent anti-microbial activity against bacteria and fungus. Polymer containing (-)OH was observed to be the most potent anti-microbial agent with the lowest minimum inhibitory concentration against both the classes of microbes studied.
Sharma
Sunil K
SK
Department of Chemistry, Himachal Pradesh University, Shimla, 171005, India.
Chauhan
Ghanshyam S
GS
Gupta
Reena
R
Ahn
J-H
JH
D000838:Anions; D000900:Anti-Bacterial Agents / Q000737:chemistry; D000890:Anti-Infective Agents / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry; D002384:Catalysis; D002412:Cations / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002852:Chromatography, Ion Exchange / Q000379:methods; D015195:Drug Design; D008422:Materials Testing; D008956:Models, Chemical; D009584:Nitrogen / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry*; D011726:Pyridinium Compounds / Q000737:chemistry*; D013997:Time Factors
D000838:Anions; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D002412:Cations; D011108:Polymers; D011145:Polyvinyls; D011726:Pyridinium Compounds; C577302:poly(4-vinyl 2-hydroxyethyl pyridinium); C027419:polydimethylvinylpyridinium; D009584:Nitrogen