title: Asthma as a predictor of obstructive sleep apnea in urban African-American children.
abstract: BACKGROUND
  Asthma is a known co-morbid factor in childhood obstructive sleep apnea (OSA); however, little is known about the effects that asthma might have on the severity of OSA. We hypothesize that children with concomitant asthma and OSA have more severe OSA.
  
  
  METHODS
  We conducted a prospective study of 50 children with OSA diagnosed by polysomnography referred for tonsillectomy and adenoidectomy (T&A). The presence of concomitant asthma was determined by ISAAC questionnaire and spirometry. Atopy to common allergens was determined by skin prick testing. Due to the relatively small sample size, we limited hypothesis testing to cross tabulations with Fisher's Exact Test and t testing. We also employed a parsimonious ordinary least squares (OLS) regression assuming a large effect size.
  
  
  RESULTS
  Subjects (n = 50) included 32 males and 41 African-Americans. Age at T&A was 9.3 +/- 3.4 years (mean +/- S.D). Thirty-two subjects reported a history of asthma during their lifetimes, but the ISAAC questionnaire detected only 30 subjects. Twenty-two subjects reported current asthma. Atopy was found in 27 subjects. Apnea-hypopnea index (AHI) was lower in the current asthma group than in the lifetime asthma group but did not reach statistical significance. However, AHI was significantly higher in subjects with poorly controlled asthma. Further, in a parsimonious OLS model controlling for sleep efficiency and age, a history of lifetime asthma increased the AHI by 8.8 (p < 0.05).
  
  
  CONCLUSIONS
  In urban African-American children referred for T&A to treat OSA, a history of poorly controlled asthma is associated with more severe OSA.
authors.affiliation: Division of Pulmonary Medicine and Cystic Fibrosis Center, Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 89 French Street, New Brunswick, NJ 08901, USA. ramagoma@umdnj.edu
authors.forename: M
authors.initials: M
authors.lastname: Ramagopal
authors.forename: A
authors.initials: A
authors.lastname: Mehta
authors.forename: D W
authors.initials: DW
authors.lastname: Roberts
authors.forename: J S
authors.initials: JS
authors.lastname: Wolf
authors.forename: R J
authors.initials: RJ
authors.lastname: Taylor
authors.forename: K E
authors.initials: KE
authors.lastname: Mudd
authors.forename: S M
authors.initials: SM
authors.lastname: Scharf
mesh_terms: D001741:Black or African American; D001249:Asthma / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D015142:Baltimore / Q000453:epidemiology; D015992:Body Mass Index; D002648:Child; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D008297:Male; D012129:Respiratory Function Tests; D012882:Skin Tests; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014505:Urban Population