title: Highly enantioselective ketone-ene reactions of trifluoropyruvate: significant counterion effect of the In(III)-pybox complex.
abstract: A chiral indium(III)-pybox complex catalyzed asymmetric ketone-ene reaction of trifluoropyruvate is described. Both aromatic and aliphatic 1,1-disubstituted alkenes reacted smoothly to give the enantioenriched tertiary homoallylic alcohols in good to excellent yields (up to 99%) and with excellent enantioselectivities (up to 98% ee).
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Zhao
authors.forename: Teguh-Budiono W
authors.initials: TB
authors.lastname: Tjan
authors.forename: Boon-Hong
authors.initials: BH
authors.lastname: Tan
authors.forename: Teck-Peng
authors.initials: TP
authors.lastname: Loh