Interactions between genetic factors that predict diabetes and dietary factors that ultimately impact on risk of diabetes.
OBJECTIVE
The purpose of the present review is to summarize recent advances in investigations of interactions between established genetic and dietary risk factors for type 2 diabetes (T2D).


RESULTS
Several studies reported that dietary factors related to carbohydrate quality and quantity, such as whole grains and glycemic load, might interact with transcription factor 7-like 2 variants in relation to T2D risk. The genetic predisposition defined by the combination of 10 established T2D risk alleles was found to modulate the association between Western dietary pattern (high intakes of red meat, processed meat, and low fiber) and T2D; a stronger association was observed in those with a high-risk genetic profile. Variants in genes HHEX, CDKN2A/2B, JAZF1, and IGF2BP2 were found to interact with prenatal nutrition in relation to T2D risk and glucose levels in later life.


CONCLUSIONS
The available data provide preliminary support for the gene-diet interactions in determining T2D. However, most findings have yet to be validated. Future studies will need agreed standards of study design and statistical power, dietary measurement, analytical methods, and replication strategies.
Qi
Lu
L
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. nhlqi@channing.harvard.edu
Liang
Jun
J
D003920:Diabetes Mellitus / Q000235:genetics*; D004032:Diet; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena; D012306:Risk; D051820:TCF Transcription Factors / Q000235:genetics; D058118:Transcription Factor 7-Like 2 Protein
D051820:TCF Transcription Factors; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein