title: Cutaneous neuroblastoma-like schwannoma: a report of two cases, one with a plexiform pattern, and a review of the literature.
abstract: Cutaneous schwannomas in their classical form are readily identified histologically. A number of variants, including ancient, cellular, epithelioid, plexiform, microcystic and neuroblastoma-like, may cause diagnostic difficulty and rarely be confused with malignancy. Neuroblastoma-like schwannoma was first described by Goldblum et al. in 1994, and very few cases have since been reported. It is a benign sporadic neoplasm with no reported association with neurofibromatosis, and is characterized histologically by small round lesional cells surrounding collagenous cores forming rosette-like structures. The differential diagnosis includes other lesions with the formation of rosettes including neuroblastoma, low-grade fibromyxoid sarcoma and dendritic cell neurofibroma, as well as primitive neuroectodermal tumors and rare malignant transformation in a schwannoma. We describe two further cases of this rare entity and review the literature on the subject. Our first case additionally has a plexiform multinodular pattern, a feature described in only one previous report.
authors.affiliation: Department of Dermatopathology, St John's Institute of Dermatology, St Thomas's Hospital, Lambeth Palace Road, London, UK.
authors.forename: Ravi
authors.initials: R
authors.lastname: Suchak
authors.forename: Bostjan
authors.initials: B
authors.lastname: Luzar
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Bacchi
authors.forename: Brigid
authors.initials: B
authors.lastname: Maguire
authors.forename: Eduardo
authors.initials: E
authors.lastname: Calonje
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D009442:Neurilemmoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009447:Neuroblastoma / Q000378:metabolism / Q000473:pathology*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor