Human telomerase gene amplification and high-risk human papillomavirus infection in women with cervical intra-epithelial neoplasia.
This study was designed to investigate whether a correlation exists between amplification of the human telomerase gene (human telomerase RNA component [TERC]) and high-risk human papillomavirus (HR-HPV) infection in 101 women with cervical intra-epithelial neoplasia (CIN). Eight patients (7.9%) had CIN 1, 24 (23.8%) had CIN 2 and 69 (68.3%) had CIN 3. TERC was amplified in 31.7% of all CIN patients. The difference in frequency of TERC amplification between patients with low-grade CIN (CIN 1) and those with high-grade CIN (CIN 2 and CIN 3) was not significant. HR-HPV infection was detected in 88.1% of all CIN cases and was significantly more frequent in patients with CIN 2 and CIN 3 than in patients with CIN 1. There was no significant difference in the frequency of HR-HPV infection between groups of patients with and without TERC amplification. In conclusion, this study found no correlation between TERC amplification and HR-HPV infection in patients with CIN.
Takac
Iztok
I
Department of Gynaecological and Breast Oncology, Maribor University Hospital, Maribor, Slovenia. iztok.takac@ukc-mb.si
Arko
D
D
Kodric
T
T
Poljak
M
M
Zagorac
A
A
Erjavec-Skerget
A
A
Kokalj-Vokac
N
N
D000328:Adult; D000368:Aged; D055088:Early Detection of Cancer; D005260:Female; D005784:Gene Amplification; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics* / Q000472:pathogenicity; D030361:Papillomavirus Infections / Q000150:complications; D011446:Prospective Studies; D012372:ROC Curve; D012307:Risk Factors; D019098:Telomerase / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology / Q000821:virology; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000473:pathology / Q000821:virology
C509186:TERT protein, human; D019098:Telomerase