title: Treatment of autonomous ovarian follicular cyst with long-term anastrozole therapy.
abstract: Functional follicular ovarian cysts are frequently reported in girls with peripheral precocious puberty (PP). These cysts are usually self-limiting and resolve spontaneously. Several drugs like antiestrogens (tamoxifen) and new aromatase inhibitors are seldom used for treatment. Here we report a girl with peripheral PP who presented with unilateral enlargement of the ovary and a recurrent autonomous ovarian cyst. No skin pigmentation or bone anomaly was noted. The patient was successfully treated with anastrozole, a highly selective aromatase inhibitor. No adverse reaction was noted. Anastrozole is a safe and tolerable drug especially used to suppress estrogen action.
authors.affiliation: Department of Pediatric Endocrinology and Metabolism, Ankara University, School of Medicine, Ankara, Turkey. oengiz@yahoo.com
authors.forename: Ozlem
authors.initials: O
authors.lastname: Engiz
authors.forename: Merih
authors.initials: M
authors.lastname: Berberoglu
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Siklar
authors.forename: Pelin
authors.initials: P
authors.lastname: Bilir
authors.forename: Gonul
authors.initials: G
authors.lastname: Ocal
mesh_terms: D000077384:Anastrozole; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D009570:Nitriles / Q000627:therapeutic use*; D010048:Ovarian Cysts / Q000188:drug therapy*; D011629:Puberty, Precocious / Q000188:drug therapy; D012008:Recurrence; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole