title: Detection of neural signals with vertically grown single platinum nanowire-nanobud.
abstract: We developed a nanoscale neural probing device for in vitro sensing of neural activity. Single vertical platinum (Pt) nanowires were fabricated on a microelectrode array by focused ion beam (FIB)-chemical vapor deposition (CVD) in order to improve the spatial resolution of recording and to minimize damage to the cells. Rat neuroblasts were cultured on the electrode array. Electrodes in contact with cells detected prominent spontaneous electrical activity. Our experiments demonstrate the nanoprobes for the real-time detection of electrophysiological signals in neuronal cells.
authors.affiliation: Department of Materials Science and Engineering, University of Idaho, Moscow, ID 83844-3024, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Choi
authors.forename: A O
authors.initials: AO
authors.lastname: Fung
authors.forename: H
authors.initials: H
authors.lastname: Moon
authors.forename: G
authors.initials: G
authors.lastname: Villareal
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: D
authors.initials: D
authors.lastname: Ho
authors.forename: N
authors.initials: N
authors.lastname: Presser
authors.forename: G
authors.initials: G
authors.lastname: Stupian
authors.forename: M
authors.initials: M
authors.lastname: Leung
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002460:Cell Line; D003460:Crystallization / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008839:Microelectrodes; D036103:Nanotechnology / Q000295:instrumentation*; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure*; D009474:Neurons / Q000502:physiology*; D010984:Platinum / Q000737:chemistry*; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D010984:Platinum