Autonomic cardiovascular modulation.
We validated a symbolic approach to assess autonomic modulation from pulse interval (PI) and systolic arterial pressure (SAP) series obtained from an animal model of chronic heart failure (CHF). We studied three groups of rats: controls; CHF animals; CHF animals treated with spironolactone (CHF-SP), reducing sympathetic activity in CHF. Simulations confirmed that symbolic analysis captures modifications of cardiovascular regulation in the case of fast dynamics and negligible variance. While spectral indexes did not reveal any significant difference among groups, symbolic analysis pointed out that sympathetic modulation is reduced in CHF group and restored to basal values in CHF-SP one.
Tobaldini
Eleonora
E
Laboratorio di Modellistica di Sistemi Complessi, Dipartimento di Tecnologie per Salute, Istituto Ortopedico Galeazzi, Università degli Studi di Milano, Via R. Galeazzi 4, 20161 Milan, Italy.
Montano
Nicola
N
Wei
Shun-Guang
SG
Zhang
Zhi-Hua
ZH
Francis
Joseph
J
Weiss
Robert M
RM
Casali
Karina R
KR
Felder
Robert B
RB
Porta
Alberto
A
D000704:Analysis of Variance; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D002908:Chronic Disease; D003198:Computer Simulation; D004195:Disease Models, Animal; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists; D017711:Nonlinear Dynamics; D011674:Pulse; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D013148:Spironolactone / Q000494:pharmacology; D018709:Statistics, Nonparametric
D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone