title: A 3-D hybrid finite element model to characterize the electrical behavior of cutaneous tissues.
abstract: Finite element modeling of the skin is useful to study the electrical properties of cutaneous tissues and gain a better understanding of the current distribution within the skin. Such an epithelial finite element model comprises extremely thin structures like cellular membranes, nuclear membranes, and the extracellular fluid. Meshing such narrow spaces considerably increases the number of elements leading to longer computing time. This also greatly reduces the number of epithelial cells that can be assembled before reaching computing limitations. To avoid the problem of meshing extremely narrow spaces while unnecessarily increasing the number of elements, we present a new hybrid modeling approach to develop a 3-D finite element model of the skin. This skin model comprises all skin layers, different lesion types, and a complete electrode model. It is used to analyze the complex electrical behavior of normal and malignant skin tissues. The current distribution within this model is also simulated to assess the depth of field achievable by an electrical impedance tomography system at different operating frequencies.
authors.affiliation: Institut de Génie Biomédical, Ecole Polytechnique de Montréal, Montréal, QC H3C 3A7, Canada. alzbeta.hartinger@polymtl.ca
authors.forename: Alzbeta E
authors.initials: AE
authors.lastname: Hartinger
authors.forename: Robert
authors.initials: R
authors.lastname: Guardo
authors.forename: Victor
authors.initials: V
authors.lastname: Kokta
authors.forename: Hervé
authors.initials: H
authors.lastname: Gagnon
mesh_terms: D022082:Cellular Structures / Q000502:physiology; D017097:Electric Impedance; D000078404:Epidermal Cells; D004817:Epidermis / Q000502:physiology; D020342:Finite Element Analysis; D006651:Histocytochemistry; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008545:Melanoma / Q000503:physiopathology; D008954:Models, Biological; D012878:Skin Neoplasms / Q000503:physiopathology; D012879:Skin Physiological Phenomena; D014054:Tomography / Q000379:methods*