title: Subjective assessment of pregnancy impact on primary lower limb lymphedema.
abstract: OBJECTIVE
  To analyze subjective influence of pregnancy on lower limb lymphedema.
  
  
  METHODS
  Cross-sectional study on 49 affected women was conducted in a single lymphology department between January 2002 and December 2006. All women were asked whether their lymphedema had worsened during pregnancy.
  
  
  RESULTS
  Mean age at lymphedema onset was 17 years, with no familial history of lymphedema. Lymphedema was unilateral for 30 women and bilateral for 19. Median age at the first delivery was 28 years. Eighteen women had only 1 pregnancy, 23 women had only 2, and 8 women had 3. For the first pregnancy, birth weight was 3.4 kg. Subjective lymphedema worsening was reported by 5 women after the first pregnancy compared to 44 women without worsening (P = .006) and after 10 (11%) of the 88 pregnancies (1 twin birth) involving 9 women. During the median 18 years since the first pregnancy, only a 14-year-old boy has developed bilateral lymphedema.
  
  
  CONCLUSIONS
  Pregnancy did not significantly exacerbate primary lower limb lymphedema.
authors.affiliation: Department of Lymphology, Centre National de Référence des Maladies Vasculaires Rares, Hôpital Cognacq-Jay, 15 rue Eugène Millon, Paris, France. stephane.vignes@hopital-cognacq-jay.fr
authors.forename: Stéphane
authors.initials: S
authors.lastname: Vignes
authors.forename: Maria
authors.initials: M
authors.lastname: Arrault
authors.forename: Raphaël
authors.initials: R
authors.lastname: Porcher
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008209:Lymphedema / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D012189:Retrospective Studies; D055815:Young Adult