title: No positive effect of autologous platelet gel after total knee arthroplasty.
abstract: OBJECTIVE
  Activated platelets release a cocktail of growth factors, some of which are thought to stimulate repair. We investigated whether the use of autologous platelet gel (PG) in total knee arthroplasty (TKA) would improve wound healing and knee function, and reduce blood loss and the use of analgesics.
  
  
  METHODS
  102 patients undergoing TKA were randomly assigned to a PG group (n = 50) or to a control (C) group (n = 52). The primary analysis was based on 73 participants (PG: 32; C: 41) with comparison of postoperative wound scores, VAS, WOMAC, knee function, use of analgesics, and the pre- and postoperative hemoglobin values after a follow-up of 3 months. 29 participants were excluded due to insufficient data.
  
  
  RESULTS
  The characteristics of the protocol-compliant patients were similar to those of the patients who were excluded. Analysis was per protocol and focused on the remaining 73 patients. At baseline and after 3 months of follow-up, there were no statistically significant differences between both groups regarding age, height, weight, sex, side of operation, platelet count, hemoglobin values, severity of complaints (WOMAC), and level of pain.
  
  
  CONCLUSIONS
  In our patients undergoing TKA, application of PG to the wound site did not promote wound healing. Also, we found that PG had no effect on pain, knee function, or hemoglobin values.
authors.affiliation: Department of Orthopaedic Surgery, HAGA Hospital, The Hague, the Netherlands. jcpeerbooms@yahoo.com
authors.forename: Joost C
authors.initials: JC
authors.lastname: Peerbooms
authors.forename: Gideon S
authors.initials: GS
authors.lastname: de Wolf
authors.forename: Joost W
authors.initials: JW
authors.lastname: Colaris
authors.forename: Daniël J
authors.initials: DJ
authors.lastname: Bruijn
authors.forename: Jan A N
authors.initials: JA
authors.lastname: Verhaar
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects / Q000379:methods / Q000534:rehabilitation; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D017063:Outcome Assessment, Health Care; D010147:Pain Measurement; D017713:Platelet Transfusion; D020127:Recovery of Function; D016896:Treatment Outcome; D014945:Wound Healing