title: Basic technique and anatomically imposed limitations of confocal scanning laser Doppler flowmetry at the optic nerve head level.
abstract: Many studies have suggested an association between blood flow dysregulation and glaucomatous damage to the optic nerve. Confocal scanning laser Doppler flowmetry (CSLDF) is a technique that measures the capillary blood flow of the retina and optic nerve head and provides a two-dimensional map of ocular perfusion in these areas. This review discusses the anatomy of the anterior optic nerve vasculature and the capabilities and limitations of the CSLDF. Methods to minimize error and to acquire more reliable measurements of capillary blood flow are also outlined.
authors.affiliation: Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Palm Beach Gardens, Florida, USA. msehi@med.miami.edu
authors.forename: Mitra
authors.initials: M
authors.lastname: Sehi
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D002196:Capillaries / Q000502:physiology; D019842:Ciliary Arteries / Q000033:anatomy & histology* / Q000502:physiology; D005901:Glaucoma / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D009412:Nerve Fibers / Q000502:physiology; D009880:Ophthalmic Artery / Q000033:anatomy & histology* / Q000502:physiology; D009898:Optic Disk / Q000098:blood supply*; D009900:Optic Nerve / Q000098:blood supply*; D012039:Regional Blood Flow / Q000502:physiology; D015203:Reproducibility of Results; D012161:Retinal Artery / Q000033:anatomy & histology* / Q000502:physiology