A new mechanism of phosphoregulation in signal transduction pathways.
Histidine protein kinases and serine, threonine, or tyrosine protein kinases play essential roles in signal transduction in prokaryotes and eukaryotes. A third type of protein kinase, an arginine protein kinase, has been identified. McsB of Bacillus subtilis phosphorylates the heat shock transcriptional regulator CtsR and can be regarded as the founding member of arginine protein kinases.
Jung
Kirsten
K
Munich Center of Integrated Protein Science (CIPSM), Ludwig-Maximilians-Universität München, Mikrobiologie, 82152 Martinsried, Germany. jung@lmu.de
Jung
Heinrich
H
D001412:Bacillus subtilis / Q000201:enzymology; D001426:Bacterial Proteins / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction
D001426:Bacterial Proteins; D011494:Protein Kinases; C423322:McsB protein, Bacillus subtilis