Alginate-antacid combinations: raft formation and gastric retention studies.
BACKGROUND
Alginate-based gastroesophageal reflux disease treatments have been used extensively and fall into two main categories. Those containing alginate as the principle active agent and those containing alginate in combination with a significant amount of antacid.


METHODS
The effectiveness of the raft formed by a new alginate/antacid suspension (Gaviscon Double Action Liquid, GDAL), in which calcium carbonate was the main antacid ingredient, was compared with those of existing alginate/antacid suspensions.


RESULTS
GDAL had similar raft strength and improved raft resilience than Gaviscon Liquid (GL), and both were significantly greater than five other products tested. Gastric retention of GDAL was similar to that of GL.


CONCLUSIONS
the in vitro and in vivo performance is maintained in the new GDAL formulation even with higher antacid levels and the product is as good as, or better than, previous formulations.
Hampson
Frank C
FC
Technostics Limited, Hull, UK.
Jolliffe
Ian G
IG
Bakhtyari
Arash
A
Taylor
Glyn
G
Sykes
John
J
Johnstone
Lesley M
LM
Dettmar
Peter W
PW
D000328:Adult; D000464:Alginates / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000863:Antacids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation* / Q000379:methods; D018592:Cross-Over Studies; D004338:Drug Combinations; D018565:Food-Drug Interactions / Q000502:physiology; D005753:Gastric Mucosa / Q000378:metabolism*; D005764:Gastroesophageal Reflux / Q000000981:diagnostic imaging / Q000188:drug therapy; D020723:Glucuronic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics; D006603:Hexuronic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D013270:Stomach / Q000000981:diagnostic imaging* / Q000187:drug effects; D055815:Young Adult
D000464:Alginates; D000863:Antacids; D004338:Drug Combinations; D006603:Hexuronic Acids; D020723:Glucuronic Acid