Hypomania with hypersexuality following bilateral anterior limb stimulation in obsessive-compulsive disorder.
This 28-year-old Chinese man was referred for deep brain stimulation (DBS) evaluation for an 8-year history of refractory obsessive-compulsive disorder. After the patient had signed an informed consent, the authors implanted DBS leads. Hypomania with hypersexuality was noted on stimulation at Contact 2 and became aggravated with a higher voltage (> or = 3 V) during chronic bilateral DBS. After the voltage was decreased to 1 V, the patient's hypomanic symptoms subsided and his libido returned to baseline.
Chang
Chun-Hung
CH
Department of Psychiatry, Buddhist Tzu-Chi General Hospital and University, Hualien City, Taiwan, Republic of China.
Chen
Shin-Yuan
SY
Hsiao
Yi-Ling
YL
Tsai
Sheng-Tzung
ST
Tsai
Hsin-Chi
HC
D000328:Adult; D000339:Affect / Q000502:physiology; D001714:Bipolar Disorder / Q000503:physiopathology*; D001931:Brain Mapping; D046690:Deep Brain Stimulation / Q000379:methods*; D003865:Major Depressive Disorder / Q000503:physiopathology / Q000628:therapy; D004292:Dominance, Cerebral / Q000502:physiology*; D004567:Electrodes, Implanted; D005059:Euphoria / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology / Q000628:therapy*; D012008:Recurrence; D012725:Sexual Behavior / Q000502:physiology*; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure