title: Are HLA DQB1 alleles correlated with breast cancer histopronostic parameters in Tunisia?
abstract: BACKGROUND
  Tumor cells express surface structures different from normal cells. These structures may be recognized by the immune system, which ensure anti-tumoral surveillance. Antigenic presentation requires HLA molecules role. Since, these molecules are encoded by a high polymorphic system, immune response can be modulated according to HLA genotype. So, HLA polymorphism could be correlated with tumor escape from anti-tumor immunosurveillance.
  
  
  OBJECTIVE
  We have aimed to search for possible associations between HLA DQB1 alleles and the histoprognostical parameters in breast cancer in the Tunisian population.
  
  
  METHODS
  DQB1 alleles were determined by PCR-SSO molecular typing in 100 healthy matched and unrelated Tunisian female and 87 Tunisian women with breast cancer.
  
  
  RESULTS
  Allelic distribution between the two studied groups showed no significant associations between this locus and the occurrence, the EE grade and the lymph node invasion of breast cancer in the Tunisian population.
  
  
  CONCLUSIONS
  This result may be explained by the fact that cancer is a multifactoral disease due to several interacting factors that might change from one population to another.
authors.affiliation: Laboratoire de Génétique, Immunologie et Pathologies Humaines, Faculté des sciences de Tunis.
authors.forename: Amal
authors.initials: A
authors.lastname: Baccar
authors.forename: Besma Yacoubi
authors.initials: BY
authors.lastname: Loueslati
authors.forename: Wafa
authors.initials: W
authors.lastname: Troudi
authors.forename: Slama
authors.initials: S
authors.lastname: Hmida
authors.forename: Amel
authors.initials: A
authors.lastname: Dridi
authors.forename: Afef
authors.initials: A
authors.lastname: Jridi
authors.forename: Karima
authors.initials: K
authors.lastname: Mrad
authors.forename: Khaled
authors.initials: K
authors.lastname: Ben Romdhane
authors.forename: Amel
authors.initials: A
authors.lastname: Ben Ammar Elgaaied
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D014416:Tunisia
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen