Synthesis and evaluation of l-5-(2-[(18)F]fluoroethoxy)tryptophan as a new PET tracer.
A convenient remote controlled synthesis of a new tryptophan analog, l-5-(2-[(18)F] fluoroethoxy)-tryptophan (5-(18)FEHTP) was described. The radiochemical yield within 65min was about 12-16% without decay correction, the radiochemical purity was over 98%, and 5-(18)FEHTP dissolved in saline was stable over 6h at room temperature. The biodistribution of 5-(18)FEHTP in mice and the high uptake of 5-(18)FEHTP in tumor demonstrated that it is very likely a new PET tracer for tumor imaging.
Li
Ruifen
R
Department of Nuclear Medicine, Perking Union Medical College Hospital, Chinese Academy of Medical Sciences & Perking Union Medical College, Beijing 100730, China. scw@public.bta.net.cn
Wu
Shih-Chen
SC
Wang
Shih-Chen
SC
Fu
Zhe
Z
Dang
Yonghong
Y
Huo
Li
L
D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D007089:Image Enhancement / Q000379:methods; D007249:Inflammation / Q000000981:diagnostic imaging* / Q000378:metabolism; D007553:Isotope Labeling / Q000379:methods; D008657:Metabolic Clearance Rate; D051379:Mice; D009928:Organ Specificity; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics
C547761:5-(2-fluoroethoxy)tryptophan; D019275:Radiopharmaceuticals; D014364:Tryptophan