title: The FRAGAMP study: environmental and genetic factors in Parkinson's disease, methods and clinical features.
abstract: The Fattori di Rischio Ambientali e Genetici Associati alla Malattia di Parkinson (FRAGAMP) study is a multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in Parkinson's disease (PD). Cases and controls were enrolled from five Movement Disorder centers in Central-Southern Italy. PD was diagnosed according to Gelb's criteria while the control groups consisted of the spouses of the enrolled patients or of healthy controls matched by age and area of residence. Cases and controls underwent a standardised questionnaire and a blood sample was taken for molecular analyses. At the end of the study 585 cases and 481 control subjects (287 spouse-controls and 194 generic-controls) were enrolled. Patients had a Hoehn-Yahr score of 2.3 +/- 0.8; 85% of them took levodopa and 47% had motor complications. The FRAGAMP study represents one of the largest case-control studies carried out in Europe to investigate the possible role of environmental and genetic factors in PD.
authors.affiliation: Dipartimento di Neuroscienze, Università di Catania, Via Santa Sofia 78, 95123 Catania, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Nicoletti
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Pugliese
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nicoletti
authors.forename: Gennarina
authors.initials: G
authors.lastname: Arabia
authors.forename: Grazia
authors.initials: G
authors.lastname: Annesi
authors.forename: Michele
authors.initials: M
authors.lastname: De Mari
authors.forename: Paolo
authors.initials: P
authors.lastname: Lamberti
authors.forename: Simone
authors.initials: S
authors.lastname: Gallerini
authors.forename: Roberto
authors.initials: R
authors.lastname: Marconi
authors.forename: Antonio
authors.initials: A
authors.lastname: Epifanio
authors.forename: Letterio
authors.initials: L
authors.lastname: Morgante
authors.forename: Autilia
authors.initials: A
authors.lastname: Cozzolino
authors.forename: Paolo
authors.initials: P
authors.lastname: Barone
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Torchia
authors.forename: Aldo
authors.initials: A
authors.lastname: Quattrone
authors.forename: Mario
authors.initials: M
authors.lastname: Zappia
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D018491:Dopamine Agonists / Q000627:therapeutic use; D020820:Dyskinesias / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D004777:Environment; D005260:Female; D020022:Genetic Predisposition to Disease; D005843:Geography; D006801:Humans; D007558:Italy / Q000453:epidemiology; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012720:Severity of Illness Index; D018454:Spouses; D011795:Surveys and Questionnaires
chemical_list: D000978:Antiparkinson Agents; D018491:Dopamine Agonists; D007980:Levodopa