Telomeres: the long and short of developing non-Hodgkin lymphoma.
Chromosomal integrity is vital to the life span of the dividing cell. Telomeres are tandem sequences at chromosome ends that provide protection for the genetic coding material. Erosion of those ends leads to cell death. Does stabilization promote cancer?
Noy
Ariela
A
Department of Medicine, Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. noya@mskcc.org
D016923:Cell Death; D002875:Chromosomes / Q000648:ultrastructure; D015331:Cohort Studies; D006801:Humans; D008214:Lymphocytes / Q000166:cytology; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism* / Q000473:pathology; D008297:Male; D012107:Research Design; D012306:Risk; D012907:Smoking; D016615:Telomere / Q000502:physiology* / Q000648:ultrastructure