title: Polarity is destiny.
abstract: The GTPase Cdc42 specifies polarity in various biological processes. Kesavan et al. (2009) now demonstrate that Cdc42 also regulates epithelial cell polarity in the developing mouse pancreas, where it is required for tubule formation and maintenance. Furthermore, the polarization of epithelial tissue influences the differentiation of pancreatic progenitor cells, linking cell polarity to cell specification.
authors.affiliation: Department of Anatomy, University of California, San Francisco, CA 94143-2140, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Cai
authors.forename: Keith
authors.initials: K
authors.lastname: Mostov
mesh_terms: D000818:Animals; D016764:Cell Polarity; D004847:Epithelial Cells / Q000166:cytology; D051379:Mice; D038081:Organogenesis; D010179:Pancreas / Q000166:cytology / Q000196:embryology*