The effects of anterior cruciate ligament lesion on the articular cartilage of growing goats.
Treatment of anterior cruciate ligament (ACL) injury in skeletally immature patients is controversial. The growth plate could be damaged if treated with the reconstruction techniques used to treat instability in adults. For this reason, many authors postpone surgical treatment until skeletal maturity, but the acceptable length of time that treatment can be postponed without causing irreversible damage to the articular cartilage in children with ACL injury is unknown. Until now, no studies have described the pathological findings and the evolution of the lesions of the articular cartilage during the growing period. For this reason, an experimental study on 16 6-month-old, skeletally immature goats was performed. A complete ACL lesion was achieved by removing the ligament. Two animals per group were sacrificed at intervals of 1, 3, 6, and 9 months postoperatively, and macroscopic and microscopic evaluations were performed. The presence of meniscal injury and articular cartilage lesions with progressive aspects were histologically underlined. The hystological observations showed that the complete ACL lesion causes irreversible articular cartilage alterations in growing goats 3 months after injury. These experimental data suggest that ACL reconstruction in growing patients with ACL injury and instability should be indicated without waiting until skeletal maturity.
Falciglia
Francesco
F
Orthopedics and Traumatology Department, Bambino Gesù Children's Hospital, Institute of Scientific Research, Rome, Italy. falciglia@opbg.net
Mastantuoni
Giuseppe
G
Guzzanti
Vincenzo
V
D000818:Animals; D000070598:Anterior Cruciate Ligament Injuries; D001696:Biomechanical Phenomena; D002358:Cartilage, Articular / Q000254:growth & development* / Q000473:pathology; D004195:Disease Models, Animal; D006041:Goats; D008297:Male; D008592:Menisci, Tibial / Q000254:growth & development* / Q000473:pathology