title: High-definition colonoscopy detects colorectal polyps at a higher rate than standard white-light colonoscopy.
abstract: OBJECTIVE
  Adenoma detection rates might be improved through use of high-definition colonoscopy, which can detect subtle mucosal changes. We investigated whether the use of high-definition white-light (HDWL) colonoscopy resulted in a higher rate of adenoma detection than standard-definition white-light (SDWL) colonoscopy in a clinical practice setting.
  
  
  METHODS
  This retrospective study included 2430 patients who underwent colonoscopies from September 2006 to December 2007; 1226 received SDWL colonoscopy and 1204 received HDWL colonoscopy. We analyzed data from consecutive screening, surveillance, and diagnostic colonoscopies, comparing adenoma and overall polyp detection between procedures. Potentially confounding variables were controlled using multivariable logistic regression analysis.
  
  
  RESULTS
  The adenoma detection rate was higher among patients who underwent HDWL compared with SDWL colonoscopies (28.8% vs 24.3%; P = .012), as was the polyp detection rate (42.2% vs 37.8%; P = .026). These findings remained after adjustments for potentially confounding variables (P = .018 and .022, respectively).
  
  
  CONCLUSIONS
  In a general clinical practice setting, HDWL colonoscopy resulted in a higher adenoma detection rate compared with SDWL colonoscopy. The use of SDWL colonoscopy could reduce the number of missed adenomas and the subsequent risk for colorectal cancer.
authors.affiliation: Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida 32224, USA.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Buchner
authors.forename: Muhammad W
authors.initials: MW
authors.lastname: Shahid
authors.forename: Michael G
authors.initials: MG
authors.lastname: Heckman
authors.forename: Rebecca B
authors.initials: RB
authors.lastname: McNeil
authors.forename: Patrick
authors.initials: P
authors.lastname: Cleveland
authors.forename: Kanwar R
authors.initials: KR
authors.lastname: Gill
authors.forename: Anthony
authors.initials: A
authors.lastname: Schore
authors.forename: Marwan
authors.initials: M
authors.lastname: Ghabril
authors.forename: Massimo
authors.initials: M
authors.lastname: Raimondo
authors.forename: Seth A
authors.initials: SA
authors.lastname: Gross
authors.forename: Michael B
authors.initials: MB
authors.lastname: Wallace
mesh_terms: D000236:Adenoma / Q000175:diagnosis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003113:Colonoscopy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007417:Intestinal Polyps / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult