Mansouramycins A-D, cytotoxic isoquinolinequinones from a marine streptomycete.
Chemical screening of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate Mei37 resulted in five isoquinolinequinones, four new derivatives, mansouramycin A-D (1, 3-5), and the known 3-methyl-7-(methylamino)-5,8-isoquinolinedione (2). Their structures were elucidated by NMR and MS techniques and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated significant cytotoxicity of several derivatives, with pronounced selectivity for non-small cell lung cancer, breast cancer, melanoma, and prostate cancer cells.
Hawas
Usama W
UW
Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Shaaban
Mohamed
M
Shaaban
Khaled A
KA
Speitling
Michael
M
Maier
Armin
A
Kelter
Gerhard
G
Fiebig
Heinz H
HH
Meiners
Marinus
M
Helmke
Elisabeth
E
Laatsch
Hartmut
H
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008297:Male; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013302:Streptomyces / Q000737:chemistry
C546300:3-(1H-indol-3-yl)-7-methylaminoisoquinoline-5,8-dione; D000970:Antineoplastic Agents; D007546:Isoquinolines