title: Deciphering the molecular basis of venous thromboembolism: where are we and where should we go?
abstract: Venous thromboembolism (VTE) is a frequent disease that has a major genetic component of risk. However, known identified genetic risk factors account for <30% of idiopathic (without any environmental origin) VTE cases. This article aims to review the lessons learnt during recent decades in the field of the genetics of VTE, describe the present state-of-art methods and discuss promising themes for finding new susceptibility loci.
authors.affiliation: INSERM UMR S626, Faculty of Medicine, University of the Mediterranean, Marseille, France. pmorange@ap-hm.fr
authors.forename: Pierre-Emmanuel
authors.initials: PE
authors.lastname: Morange
authors.forename: David-Alexandre
authors.initials: DA
authors.lastname: Tregouet
mesh_terms: D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000235:genetics*