Daphhimalenine A, a new alkaloid with an unprecedented skeleton, from Daphniphyllum himalense.
Daphhimalenine A (1), a novel alkaloid with a rearrangement C-21 skeleton, containing a unique 1-azabicyclo[5.2.1]decane ring system, was isolated from the leaves of Daphniphyllum himalense, along with biogenetically related alkaloids daphhimalenine B (2) and daphnezomine T. Their structures were established on the basis of spectroscopic data, and the absolute configuration of 1 was assigned by computational methods. A plausible biosynthetic pathway of 1 was also proposed.
Zhang
Yu
Y
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
Di
Ying-Tong
YT
Zhang
Qiang
Q
Mu
Shu-Zhen
SZ
Tan
Cheng-Jian
CJ
Fang
Xin
X
He
Hong-Ping
HP
Li
Shun-Lin
SL
Hao
Xiao-Jiang
XJ
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D031995:Saxifragaceae / Q000737:chemistry*
D000470:Alkaloids; C546480:daphhimalenine A