title: Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation.
abstract: The aim of this work was to determine the effect of chronic treatment with 5 mg/kg of tianeptine in male adult Wistar rats separated from the mother as neonates and submitted to variable chronic stress, plasma catecholamines, and anxiety. The plus maze test was performed in order to calculate the anxiety index and catecholamine levels were determined by high-pressure liquid chromatography. Both stress and maternal separation elevated catecholamine levels without affecting anxiety. In the maternally separated stress group, tianeptine decreased epinephrine. Anxiety was reduced in the maternally separated unstressed tianeptine group. Also, all groups showed a tendency to lower anxiety index.
authors.affiliation: Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: Verónica
authors.initials: V
authors.lastname: Trujillo
authors.forename: María Lujan
authors.initials: ML
authors.lastname: Masseroni
authors.forename: Gloria
authors.initials: G
authors.lastname: Levin
authors.forename: Marta Magdalena
authors.initials: MM
authors.lastname: Suárez
mesh_terms: D000305:Adrenal Cortex Hormones / Q000097:blood; D000313:Adrenal Medulla / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D001007:Anxiety / Q000097:blood* / Q000188:drug therapy* / Q000523:psychology; D001010:Anxiety, Separation / Q000097:blood* / Q000150:complications* / Q000523:psychology; D001522:Behavior, Animal / Q000502:physiology; D002395:Catecholamines / Q000097:blood*; D002908:Chronic Disease; D005260:Female; D008297:Male; D008426:Maternal Deprivation; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000097:blood* / Q000150:complications* / Q000523:psychology; D013841:Thiazepines / Q000627:therapeutic use*
chemical_list: D000305:Adrenal Cortex Hormones; D000929:Antidepressive Agents, Tricyclic; D002395:Catecholamines; D013841:Thiazepines; C050504:tianeptine