title: Ellagic acid derivatives from Syzygium cumini stem bark: investigation of their antiplasmodial activity.
abstract: Bioguided fractionation of Syzygium cumini (Myrtaceae) bark decoction for antiplasmodial activity was performed, leading to the isolation of three known ellagic acid derivatives (ellagic acid, ellagic acid 4-O-alpha-L-2"-acetylrhamnopyranoside, 3-O-methylellagic acid 3'-O-alpha-L-rhamnopyranoside), as well as the new derivative 3-O-methylellagic acid 3'-O-beta-D-glucopyranoside. Activity investigation was based on the reduction of P. falciparum (PfK1) parasitaemia in vitro and the inhibition of beta-hematin formation, a known mechanism of action of some antimalarial drugs. Among the investigated ellagic acid derivatives, only ellagic acid was able to reduce P. falciparum parasitaemia in vitro and inhibit beta-hematin formation, suggesting that free hydroxyl groups are necessary for activity within this class of compounds.
authors.affiliation: Laboratory of Pharmacognosy and Phytochemistry, Ecole de Pharmacie Genève-Lausanne, University of Geneva, University of Lausanne, CH-1211 Genève 4, Switzerland. Claudia.pires@unige.ch
authors.forename: Claudia A
authors.initials: CA
authors.lastname: Simões-Pires
authors.forename: Sandra
authors.initials: S
authors.lastname: Vargas
authors.forename: Andrew
authors.initials: A
authors.lastname: Marston
authors.forename: Jean-Robert
authors.initials: JR
authors.lastname: Ioset
authors.forename: Marçal Q
authors.initials: MQ
authors.lastname: Paulo
authors.forename: An
authors.initials: A
authors.lastname: Matheeussen
authors.forename: Louis
authors.initials: L
authors.lastname: Maes
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004610:Ellagic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D018547:Plant Stems; D010963:Plasmodium falciparum / Q000187:drug effects*; D027842:Syzygium / Q000737:chemistry*
chemical_list: D000962:Antimalarials; D004610:Ellagic Acid