title: Lack of association between angiotensin I-converting enzyme insertion/deletion polymorphism and psoriasis or psoriatic arthritis in Spain.
abstract: Data on the potential influence of the angiotensin-converting enzyme (ACE) insertion/ deletion (I/D) genotype on psoriasis are contradictory. Our aim was to investigate the relationship between the ACE gene I/D polymorphism and psoriasis/psoriatic arthritis. To investigate this, a genetic association study was conducted among 268 unrelated patients with psoriasis and 272 controls. The distribution of DD, ID, and II genotypes did not significantly differ between psoriatic patients and controls (DD: 39.6% vs. 34.2%; ID: 46.3% vs. 53.3%; II: 14.1% vs. 12.5%). In conclusion, the ACE polymorphism is not likely to be associated with either psoriasis or psoriatic arthritis in this study.
authors.affiliation: Dermatología II department, Hospital Universitario Central de Asturias, Oviedo, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Coto-Segura
authors.forename: Victoria
authors.initials: V
authors.lastname: Alvarez
authors.forename: Javier
authors.initials: J
authors.lastname: Soto-Sánchez
authors.forename: Blanca
authors.initials: B
authors.lastname: Morales
authors.forename: Eliecer
authors.initials: E
authors.lastname: Coto
authors.forename: Jorge
authors.initials: J
authors.lastname: Santos-Juanes
mesh_terms: D000328:Adult; D015535:Arthritis, Psoriatic / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000201:enzymology / Q000235:genetics*; D017384:Sequence Deletion; D013030:Spain; D044465:White People / Q000235:genetics
chemical_list: D007703:Peptidyl-Dipeptidase A