title: Electrochemical determination of morphine at ordered mesoporous carbon modified glassy carbon electrode.
abstract: A sensitive electrochemical detection scheme for morphine has been proposed by utilizing the ordered mesoporous carbon modified glassy carbon electrode (OMC/GCE). The electrochemical behaviour of morphine at the OMC/GCE was investigated by cyclic voltammetry. The modified electrode displayed a decrease in the overpotential (ca. 82mV) and an obvious increase in the peak current (80 times) compared to the bare glassy carbon electrode (GCE). The results indicated that OMC/GCE remarkably enhanced electrocatalytic activity towards the oxidation of morphine. Linear response was found over the range from 0.1 microM to 20 microM with a high sensitivity of 1.74 microA/microM and low detection limit of 10 nM (S/N=3). And the relative standard deviation was 0.86% (n=5). Moreover, combining with a medium-exchange procedure, the OMC/GCE has also been successfully applied to the selective determination of morphine in urine samples with a low detection limit of 50 nM and satisfied recovery of 96.4%. The good results indicate that the OMC/GCE holds great promise in practical application.
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied, Chemistry, Graduate University of the Chinese Academy of Sciences, Chinese, Academy of Sciences, Changchun, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.forename: Jixia
authors.initials: J
authors.lastname: Song
authors.forename: Changsheng
authors.initials: C
authors.lastname: Shan
authors.forename: Dongmei
authors.initials: D
authors.lastname: Gao
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Xu
authors.forename: Li
authors.initials: L
authors.lastname: Niu
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D002244:Carbon / Q000737:chemistry*; D004563:Electrochemistry / Q000295:instrumentation*; D004566:Electrodes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005898:Glass / Q000737:chemistry; D009020:Morphine / Q000032:analysis* / Q000737:chemistry; D016062:Porosity; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015813:Substance Abuse Detection / Q000295:instrumentation*
chemical_list: D002244:Carbon; D009020:Morphine