title: Evaluation of desensitizing agents on dentin permeability and dentinal tubule occlusion: an in vitro study.
abstract: One hundred twelve specimens from bovine incisors were divided into eight groups: Group 1 (treated with 10% strontium chloride gel), Group 2 (treated with 2% sodium fluoride gel), Group 3 (treated with 2% stannous fluoride gel), Group 4 (treated with 5% potassium nitrate gel), Group 5 (treated with 10% potassium nitrate gel), Group 6 (treated with 3% potassium oxalate gel), Group 7 (treated with hydroxyethylcellulose gel), and Group 8 (which received no treatment). Dentinal tubules were exposed after 0.5 mm of deep abrasion using a carbide bur and EDTA gel application. After each treatment, dentin permeability, tubule occlusion, and chemical elements on dentin were analyzed. There was a significant difference among groups in dentin permeability (p < 0.05 ANOVA). Groups 4, 5, and 6 showed the lowest values, while Groups 1, 7, and 8 exhibited the highest. Groups 1, 2, 3, 7, and 8 showed open dentinal tubules, Groups 4 and 5 had partial tubule occlusion, and most of the tubules in Group 6 were obliterated. Energy-dispersive x-rays revealed similar chemical characteristics among the experimental agents used, with traces of strontium, fluoride, sodium, and potassium. Within the limits of the study, 3% potassium oxalate gel showed the best results in terms of dentin permeability and dentinal tubule occlusion.
authors.affiliation: Department of Dentistry, State University of Ponta Grossa, Parana, Brazil.
authors.forename: Carolina
authors.initials: C
authors.lastname: Oberg
authors.forename: Marcia Thais
authors.initials: MT
authors.lastname: Pochapski
authors.forename: Paulo Vitor
authors.initials: PV
authors.lastname: Farago
authors.forename: Carlos Jose Fernandes
authors.initials: CJ
authors.lastname: Granado
authors.forename: Gibson Luiz
authors.initials: GL
authors.lastname: Pilatti
authors.forename: Fabio Andre
authors.initials: FA
authors.lastname: Santos
mesh_terms: D000818:Animals; D002417:Cattle; D002482:Cellulose / Q000031:analogs & derivatives / Q000494:pharmacology; D002614:Chelating Agents / Q000494:pharmacology; D003804:Dentin / Q000187:drug effects* / Q000648:ultrastructure; D057133:Dentin Desensitizing Agents / Q000494:pharmacology*; D003806:Dentin Permeability / Q000187:drug effects*; D004492:Edetic Acid / Q000494:pharmacology; D004577:Electron Probe Microanalysis; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D009566:Nitrates / Q000494:pharmacology; D010070:Oxalates / Q000494:pharmacology; D017680:Potassium Compounds / Q000494:pharmacology; D016622:Silver Staining; D016369:Smear Layer; D012969:Sodium Fluoride / Q000494:pharmacology; D013324:Strontium / Q000494:pharmacology; D014002:Tin Fluorides / Q000494:pharmacology; D014072:Tooth Abrasion / Q000473:pathology
chemical_list: D002614:Chelating Agents; D057133:Dentin Desensitizing Agents; D009566:Nitrates; D010070:Oxalates; D017680:Potassium Compounds; D014002:Tin Fluorides; D012969:Sodium Fluoride; D002482:Cellulose; C002283:hydroxyethylcellulose; D004492:Edetic Acid; C025700:strontium chloride; C023844:potassium nitrate; D013324:Strontium