title: Computational model of rib movement and its application in studying the effects  of age-related thoracic cage calcification on respiratory system.
abstract: A 3D finite element model of rib cage movement is developed and used to study the role of age-related costal cartilage and sternocostal joint calcification, as well as respiratory muscle weakness on the 'bucket-handle' movement of human rib. The volume displacement of the rib cage is related to changes in its circumference using an empirical equation presented by Agostoni et al. (1965, J Appl Physiol, 20:1179-1186). A systematic study is carried out to quantify the role of costal cartilage, sternocostal joint calcification and muscle weakness on the volume displacement of the rib cage. The results provide insight into some of the mechanisms underlying age-related changes in the respiratory system.
authors.affiliation: Department of Mechanical, Industrial and Manufacturing Engineering, Northeastern University, Boston, MA 02115, USA. vaziri@coe.neu.edu
authors.forename: A
authors.initials: A
authors.lastname: Vaziri
authors.forename: H
authors.initials: H
authors.lastname: Nayeb-Hashemi
authors.forename: B
authors.initials: B
authors.lastname: Akhavan-Tafti
mesh_terms: D000375:Aging / Q000502:physiology; D001698:Biomedical Engineering; D002114:Calcinosis / Q000473:pathology / Q000503:physiopathology*; D002356:Cartilage / Q000503:physiopathology; D003198:Computer Simulation; D004548:Elasticity; D020342:Finite Element Analysis; D006801:Humans; D021621:Imaging, Three-Dimensional; D016014:Linear Models; D008953:Models, Anatomic; D008954:Models, Biological; D009068:Movement / Q000502:physiology; D015656:Respiratory Mechanics / Q000502:physiology*; D012132:Respiratory Muscles / Q000503:physiopathology; D012272:Ribs / Q000473:pathology / Q000503:physiopathology*; D035423:Thoracic Cavity / Q000503:physiopathology