title: Attitude towards genetic testing for breast cancer susceptibility: a comparison of affected and unaffected women.
abstract: The objective of this study is to evaluate women's awareness and interest in genetic testing for breast cancer risk, to identify socio-demographic factors, to analyse the reasons for wanting or not wanting to be tested and finally to determine whether breast cancer patients and healthy women have different attitudes towards genetic testing. Consecutive series of 879 women without and with breast cancer participated in a 20-item self-completing questionnaire. Among breast cancer patients, 57% answered that they would definitely or probably accept being tested, compared with 84% of women without breast cancer. At the multiple logistic regression analysis only to have a diagnosis of breast cancer conditioned significantly the interest to have genetic testing. Surprisingly, a family history of breast cancer was found to have no significant impact. The most frequently cited reason for being interested in genetic testing was 'to learn about your children's risk'. Although women's awareness about breast cancer genes is inadequate, the interest in genetic testing is substantial and higher both in healthy women and in women with breast cancer. These results provide important indications for the development of educational strategies.
authors.affiliation: Experimental Oncology Department, Cancer Institute of Bari, Bari, Italy. m.bruno@oncologico.bari.it
authors.forename: M
authors.initials: M
authors.lastname: Bruno
authors.forename: M
authors.initials: M
authors.lastname: Digennaro
authors.forename: S
authors.initials: S
authors.lastname: Tommasi
authors.forename: B
authors.initials: B
authors.lastname: Stea
authors.forename: T
authors.initials: T
authors.lastname: Danese
authors.forename: F
authors.initials: F
authors.lastname: Schittulli
authors.forename: A
authors.initials: A
authors.lastname: Paradiso
mesh_terms: D000328:Adult; D000368:Aged; D001294:Attitude to Health; D001364:Awareness; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000523:psychology; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000523:psychology*; D006801:Humans; D016015:Logistic Models; D008403:Mass Screening / Q000379:methods / Q000523:psychology; D008875:Middle Aged; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D055815:Young Adult