title: Tricyclic antidepressant toxicity treated with massive sodium bicarbonate.
abstract: Tricyclic antidepressant (TCA) morbitity is primarily due to cardiac arrhythmias and hypotension, which become more refractory to treatment as acidosis progresses (Ann Emerg Med. 1985;14:1-9; Clin Toxicol. 2007;45:203-233; Flomenbaum N, Goldfrank L, Hoffman R, et al. Goldfrank's toxicologic emergencies. 8th ed. McGraw-Hill Companies, Inc, 2006). Early recognition and aggressive treatment are necessary for patient survival.
authors.affiliation: Lehigh Valley Hospital, Bethlehem, PA 18107, USA.
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Pierog
authors.forename: Kathleen E
authors.initials: KE
authors.lastname: Kane
authors.forename: Bryan G
authors.initials: BG
authors.lastname: Kane
authors.forename: J Ward
authors.initials: JW
authors.lastname: Donovan
authors.forename: Tracey
authors.initials: T
authors.lastname: Helmick
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy*; D003511:Cyclohexanols / Q000506:poisoning*; D003891:Desipramine / Q000506:poisoning*; D062787:Drug Overdose; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008875:Middle Aged; D017693:Sodium Bicarbonate / Q000008:administration & dosage*; D000069470:Venlafaxine Hydrochloride
chemical_list: D000929:Antidepressive Agents, Tricyclic; D003511:Cyclohexanols; D000069470:Venlafaxine Hydrochloride; D017693:Sodium Bicarbonate; D003891:Desipramine