A cross-sectional study for the analysis of clinical, sexual and laboratory conditions associated to Peyronie's disease.
BACKGROUND
Although Peyronie's Disease (PD) was first described over 250 years ago, its precise etiology remains obscure.


OBJECTIVE
Analyze a variety of potential associated factors with PD, including erectile dysfunction.


METHODS
This cross-sectional study included 83 consecutive men with PD and 252 age-matched controls. All men completed the International Index of Erectile Function (IIEF) and were evaluated regarding their clinical and demographic characteristics, comorbidities, and used medications. Anthropometric measures included body mass index and waist circumference (WC). Fasting blood glucose, lipid profile, total testosterone, and dehydroepiandrosterone-sulfate were determined.


METHODS
Clinical and laboratory characteristics associated to PD.


RESULTS
The mean age was 59.2 + or - 10 years in the cases and 59.7 + or - 12 years in the controls. Marital status, current smoking, and excessive consumption of alcoholic beverages were similar between groups (P > 0.05). PD was more common among white skin color males (P = 0.001). The mean score for each IIEF domain and the androgen levels were similar in the two groups. Thiazides were the only medication associated to PD (P = 0.03). Dupuytren's disease was more frequent among individuals with PD (P = 0.001). The distribution of all other comorbidities investigated was similar between groups (P > 0.05). The characteristics WC > 102 cm and levels of low-density lipoprotein (LDL) > 130 mg/dL were more prevalent in the controls (P < 0.05). After multivariate analysis, white skin color (OR: 8.47, 95%CI: 1.98-36.24) and thiazide use (OR: 2.29, 95%CI: 1.07-4.90) were associated to PD, and LDL > 130 mg/dL (OR: 0.55, 95%CI: 0.32-0.92) and WC > 102 cm (OR: 0.53, 95%CI: 0.29-0.96) were inversely associated to PD.


CONCLUSIONS
In this study, PD was more common among white skin colored males. An inverse relationship with the presence of elevated serum levels of LDL and WC was observed. We found no association with medications other than thiazides and comorbidities other than Dupuytren's disease. Androgen serum levels and sexual dysfunction had also no association to PD.
Rhoden
Ernani Luis
EL
Universidade Federal do Rio Grande do Sul (UFRGS)-Postgraduate Course in Medical Sciences, Porto Alegre, RS, Brazil. ernanirhoden@yahoo.com.br
Riedner
Charles Edison
CE
Fuchs
Sandra C
SC
Fuchs
Sandra
S
Ribeiro
Eduardo Porto
EP
Halmenschlager
Graziele
G
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001938:Brazil; D016022:Case-Control Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D004387:Dupuytren Contracture / Q000175:diagnosis / Q000453:epidemiology; D007172:Erectile Dysfunction / Q000175:diagnosis* / Q000453:epidemiology* / Q000208:ethnology; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010411:Penile Induration / Q000175:diagnosis* / Q000453:epidemiology* / Q000208:ethnology; D012307:Risk Factors; D012725:Sexual Behavior; D012959:Socioeconomic Factors; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects; D013739:Testosterone / Q000097:blood; D055105:Waist Circumference; D044465:White People
D001786:Blood Glucose; D008055:Lipids; D049993:Sodium Chloride Symporter Inhibitors; D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate