Serum levels of reproductive hormones and ultrasonographic monitoring of ovarian follicles in female cloned dogs.
This study investigated the reproductive characteristics in 2 cloned female beagle dogs (Clones A and B) during proestrus and early estrus. The pre-ovulatory estradiol peak occurred 2 days before the pre-ovulatory luteinizing hormone (LH) surge, while the follicle stimulating hormone surge started concomitantly with the LH surge in both cloned dogs. Serum progesterone levels increased during proestrus and estrus and its concentration on the day of the LH surge was 3.59 and 2.71 ng/ml in Clones A and B, respectively. Gradual follicular growth was observed by ultrasonography during proestrus. Although the numbers are limited, these cloned female dogs showed normal ranges of reproductive hormone levels and follicular changes during proestrous and early estrous stages of the cycle.
Hong
So Gun
SG
Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
Oh
Hyun Ju
HJ
Park
Jung Eun
JE
Kang
Jung Taek
JT
Kim
Min Jung
MJ
Yoon
Jung Hee
JH
Chang
Jin Hwa
JH
Kim
Min Kyu
MK
Jang
Goo
G
Lee
Byeong Chun
BC
D000818:Animals; D019976:Cloning, Organism; D004285:Dogs / Q000033:anatomy & histology* / Q000502:physiology*; D004958:Estradiol / Q000097:blood; D030762:Estrous Cycle / Q000097:blood* / Q000502:physiology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D006080:Ovarian Follicle / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D011374:Progesterone / Q000097:blood; D014463:Ultrasonography
D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone