Clotting, immune system, and venous thrombosis in lung adenocarcinoma patients: a prospective study.
Thrombosis is highly prevalent in cancer patients, being accepted as a bad prognosis marker. The importance of various mechanisms involved in the thrombophilic state of lung cancer patients is not well understood. In this prospective study, involving 109 unselected patients with lung adenocarcinoma, thrombosis was present in 24% of patients and affected survival in a bivariable model. However, in a multivariable evaluation, considering all the factors under study, only LAC and IgM anti-beta(2) GP I modified thrombosis risk, whereas in a Kaplan-Meyer regression model, thrombosis, IL-6, LAC, factor VIII, and IgM anti-beta(2) GP I interfered with patient's survival.
de Meis
Ernesto
E
Clinical Pathology, Instituto Nacional do Câncer, Praça Cruz Vermelha 23, Centro, Rio de Janeiro, 20230-130, Brazil. edemeisrio@yahoo.com
Pinheiro
Vera R
VR
Zamboni
Mauro M
MM
Guedes
Maria Teresa S
MT
Castilho
Ilda A M
IA
Martinez
Maria Mercedes K
MM
Leda
Marys Stella O
MS
Silveira
Neura P R
NP
Rumjanek
Vivian M
VM
Levy
Roger A
RA
D000230:Adenocarcinoma / Q000097:blood / Q000150:complications* / Q000276:immunology / Q000401:mortality; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000097:blood / Q000150:complications* / Q000276:immunology / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D020246:Venous Thrombosis / Q000097:blood / Q000209:etiology* / Q000276:immunology / Q000401:mortality
D001323:Autoantibodies; D015415:Biomarkers; D016207:Cytokines