Emergence of drug resistance in HIV-1 subtype C infected children failing the South African national antiretroviral roll-out program.
HIV-1 drug resistance patterns in 41 children failing antiretroviral therapy in South Africa were examined. Resistance mutation profiles were similar to adults published from the region, with the exception of high rates of lopinavir/r resistance (44%). Ninety-eight percent presented with known drug resistance mutations with M184V (82%) and K103N (44%), the dominant mutations.
Wallis
Carole L
CL
Department of Molecular Medicine and Haematology, Wits Medical School, University of the Witwatersrand, Parktown, South Africa. cwallis@mweb.co.za
Erasmus
Linda
L
Varughese
Sheba
S
Ndiweni
Dalu
D
Stevens
Wendy S
WS
D044966:Anti-Retroviral Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D024882:Drug Resistance, Viral; D005260:Female; D006078:Government Programs; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D009154:Mutation; D012367:RNA, Viral / Q000097:blood; D013019:South Africa; D017211:Treatment Failure; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics
D044966:Anti-Retroviral Agents; D012367:RNA, Viral; D054302:pol Gene Products, Human Immunodeficiency Virus