Palladium-catalyzed hydroalkylation of styrenes with organozinc reagents to form carbon-carbon sp3-sp3 bonds under oxidative conditions.
An unconventional route for the formation of sp(3)-sp(3) C-C bonds from various styrenes and an organozinc reagent in a formal alkene hydroalkylation process is detailed. Mechanistically, this process is proposed to proceed by initial transmetalation followed by formation of a Pd-H species, which is subsequently trapped by the styrene.
Urkalan
Kaveri Balan
KB
Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-085, USA.
Sigman
Matthew S
MS
D000478:Alkylation; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013343:Styrenes / Q000138:chemical synthesis / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D009942:Organometallic Compounds; D013343:Styrenes; D010165:Palladium; D002244:Carbon; D015032:Zinc