Sustained release of a water-soluble drug from alginate matrix tablets prepared by wet granulation method.
Alginate matrix tablet of diltiazem hydrochloride (DTZ), a water-soluble drug, was prepared using sodium alginate (SAL) and calcium gluconate (CG) by the conventional wet granulation method for sustained release of the drug. The effect of formulation variables like SAL/CG ratio, drug load, microenvironmental pH modulator, and processing variable like compression force on the extent of drug release was examined. The tablets prepared with 1:2 w/w ratio of SAL/CG produced the most sustained release of the drug extending up to 13.5 h. Above and below this ratio, the drug release was faster. The drug load and the hardness of the tablets produced minimal variation in drug release. The addition of alkaline or acidic microenvironmental modulators did not extend the release; instead, these excipients produced somewhat faster release of diltiazem. This study revealed that proper selection of SAL/CG ratio is important to produce alginate matrix tablet by wet granulation method for sustained release of DTZ.
Mandal
Sanchita
S
Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India.
Basu
Sanat Kumar
SK
Sa
Biswanath
B
D000464:Alginates; D002118:Calcium / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations; D004110:Diltiazem / Q000008:administration & dosage* / Q000737:chemistry; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006863:Hydrogen-Ion Concentration; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods
D000464:Alginates; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D013607:Tablets; D020723:Glucuronic Acid; D004110:Diltiazem; D002118:Calcium