Ultrastructural modification of the endothelium in placental insufficiency and microangiopathies.
Structural reorganization of endotheliocytes was studied on models of various pathological processes: placental dysfunction, glomerular pathology, vibration syndrome, antiphospholipid syndrome, and diffuse angiokeratoma, all of these characterized by endothelial insufficiency. Universal modification of endothelial associations was revealed. It included a chain of stereotypical reactions: from degeneration alternating with compensatory hypertrophy to subsequent atrophy and death of endotheliocytes. The time course of the process was confirmed by the results of light microscopy in combination with ultrastructural examination and by evaluation of the biosynthetic reactions by in vitro radioautography.
Aidagulova
S V
SV
Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru
Zhornik
T M
TM
Nepomnyashchikh
D L
DL
Marinkin
I O
IO
Vinogradova
E V
EV
Nokhrina
Zh V
ZhV
D000293:Adolescent; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000473:pathology; D004727:Endothelium / Q000473:pathology* / Q000648:ultrastructure*; D000795:Fabry Disease / Q000473:pathology; D005260:Female; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D010920:Placenta / Q000473:pathology / Q000648:ultrastructure*; D010927:Placental Insufficiency / Q000473:pathology* / Q000821:virology; D011247:Pregnancy; D012867:Skin / Q000473:pathology / Q000648:ultrastructure; D013270:Stomach / Q000473:pathology / Q000648:ultrastructure; D055815:Young Adult