Association of thyroid autoantibodies with moyamoya-type cerebrovascular disease: a prospective study.
OBJECTIVE
To investigate the association between thyroid autoantibodies and moyamoya disease (MMD) in patients with an apparent euthyroid state.


METHODS
We prospectively studied angiographically diagnosed patients with MMD. We compared demographic profiles, thyroid function test, and thyroid autoantibody status between MMD and control groups.


RESULTS
A total of 63 patients with MMD, 71 patients with non-MMD stroke, and 200 healthy control subjects were included. The prevalence of elevated thyroid autoantibodies was higher in the MMD group than in other groups (P<0.01 for MMD versus non-MMD; P<0.001 for MMD versus control subjects). After adjusting for covariates, the elevated thyroid autoantibodies (OR, 4.871; 95% CI, 1.588 to 15.277) and smoking habits (OR, 0.206 for current smoker; 95% CI, 0.054 to 0.786) were independently associated with MMD versus non-MMD stroke.


CONCLUSIONS
Elevated thyroid autoantibodies were frequently observed in patients with MMD. The results of the present study suggest that immune aberrancies associated with or underlying thyroid autoimmunity are also playing a role in developing MMD.
Kim
Suk Jae
SJ
Department of Neurology, Samsung Medical Center, Sungkyunkwan University, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, South Korea.
Heo
Kwang Gi
KG
Shin
Hee Young
HY
Bang
Oh Young
OY
Kim
Gyeong-Moon
GM
Chung
Chin-Sang
CS
Kim
Keon Ha
KH
Jeon
Pyoung
P
Kim
Jong Soo
JS
Hong
Seung-Chyul
SC
Lee
Kwang Ho
KH
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000096:biosynthesis / Q000097:blood*; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009072:Moyamoya Disease / Q000097:blood* / Q000175:diagnosis; D011446:Prospective Studies; D013960:Thyroid Function Tests / Q000379:methods; D013963:Thyroid Hormones / Q000097:blood*; D055815:Young Adult
D001323:Autoantibodies; D013963:Thyroid Hormones