Hospitalizations for coccidioidomycosis at forty-one children's hospitals in the United States.
BACKGROUND
Coccidioidomycosis is often a self-limiting pulmonary infection, but it can cause more clinically apparent disease leading to hospitalization. We describe the characteristics of initial and subsequent hospitalizations in children with coccidioidomycosis.


METHODS
Using the Pediatric Health Information System (PHIS), an inpatient database, we identified retrospectively a cohort of patients hospitalized between April 1, 2002 and June 30, 2007 at children's hospitals across the United States. Demographic, clinical, and therapeutic data for the initial and subsequent hospitalizations were collected and analyzed.


RESULTS
We identified 199 children who had 295 hospitalizations for coccidioidomycosis. The median hospital length of stay was 7 days (interquartile range: 3-14 days). Hospital incidence rates were stable from 2003 to 2005 but increased significantly from 2005 to 2006 (8.31/100,000 discharges vs. 12.95/100,000 discharges; chi2 = 4.65, P = 0.031). Fluconazole was the most commonly used antifungal agent, but 17.1% of patients were initially managed without antifungal therapy. The presence of an underlying comorbid condition was common (34.2%) as was the need for surgical intervention (41%). In-hospital mortality was low (1.5%).


CONCLUSIONS
The increase in hospitalization rates associated with coccidioidomycosis from 2005 to 2006 mirrors the increase in cases reported to the Centers for Disease Control and Prevention during the same time period. Hospital admission for coccidioidomycosis seems to be more common in patients with underlying comorbid conditions and frequently necessitates surgical intervention.
Fisher
Brian T
BT
Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. fisherbria@email.chop.edu
Chiller
Tom M
TM
Prasad
Priya A
PA
Beveridge
Mara
M
Walsh
Thomas J
TJ
Zaoutis
Theoklis E
TE
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003047:Coccidioidomycosis / Q000453:epidemiology* / Q000473:pathology*; D015897:Comorbidity; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D014481:United States / Q000453:epidemiology