Adiponectin is independently associated with apolipoprotein B to A-1 ratio in Koreans.
Apolipoprotein B to A-1 (apo B/A-1) ratio is reportedly a better predictor of atherosclerotic vascular disease than low-density lipoprotein cholesterol (LDL-C). The aim of this study was to assess the association of serum apo B/A-1 ratio with insulin resistance and adiponectin in patients with different grades of glucose intolerance. Patients were divided according to glucose tolerance into 3 groups: normal glucose tolerance without metabolic syndrome (n = 229), impaired fasting glucose (subjects with fasting plasma glucose level between 100 and 125 mg/dL, n = 658), and type 2 diabetes mellitus (n = 381). Serum concentrations of apo B, apo A-1, glucose, total cholesterol (TC), triglycerides, and high-density lipoprotein cholesterol (HDL-C) and adiponectin were measured. Insulin resistance was estimated by the homeostasis model assessment of insulin resistance index (HOMA-IR). There were significant differences in metabolic parameters among the groups, including waist circumference, insulin, HOMA-IR, and apo B/A-1 ratio, which increased sequentially with glucose intolerance, whereas adiponectin level decreased with increasing severity of glucose intolerance. The apo B/A-1 ratio was significantly correlated with TC, triglycerides, LDL-C, HDL-C, adiponectin, and HOMA-IR in normal glucose tolerance, impaired fasting glucose, and type 2 diabetes mellitus. Multiple regression analysis showed that apo B/A-1 ratio was significantly associated with TC, LDL-C, HDL-C, and adiponectin. In conclusion, apo B/A-1 ratio was significantly associated with insulin resistance according to glucose intolerance; and serum adiponectin was an important independent factor associated with apo B/A-1 ratio in Koreans.
Park
Jong Suk
JS
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Cho
Min Ho
MH
Nam
Ji Sun
JS
Yoo
Jeong Seon
JS
Lee
Yoon Bum
YB
Roh
Jung Min
JM
Ahn
Chul Woo
CW
Jee
Sun Ha
SH
Cha
Bong Soo
BS
Lee
Eun Jig
EJ
Lim
Sung Kil
SK
Kim
Kyung Rae
KR
Lee
Hyun Chul
HC
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D018149:Glucose Intolerance; D006801:Humans; D007333:Insulin Resistance; D007723:Korea; D016014:Linear Models; D008875:Middle Aged; D015999:Multivariate Analysis; D014280:Triglycerides / Q000097:blood
D052242:Adiponectin; D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D014280:Triglycerides; D002784:Cholesterol