Chemical constituents from Clematis delavayi var. spinescens.
A new coumarin, 7-hydroxy-4,6-dimethoxy-5-methylcoumarin (1), was isolated from the aerial parts of Clematis delavayi var. spinescens together with 17 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of all compounds were evaluated using a zebrafish model.
Li
Yang
Y
Laboratory of Ethnobotany, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China. liyang@mail.kib.ac.cn.
Wang
Si-Feng
SF
Zhao
Yan-Li
YL
Liu
Ke-Chun
KC
Wang
Xi-Min
XM
Yang
Yong-Ping
YP
Li
Xiao-Li
XL
D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D000818:Animals; D039324:Clematis / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010793:Phthalazines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D015027:Zebrafish
D020533:Angiogenesis Inhibitors; D003374:Coumarins; D010793:Phthalazines; D011725:Pyridines; C404768:vatalanib; C030123:coumarin