Chitosan-alginate sponge: preparation and application in curcumin delivery for dermal wound healing in rat.
A biodegradable sponge, composed of chitosan (CS) and sodium alginate (SA), was successfully obtained in this work. The sponge was ethereal and pliable. The chemical structure and morphology of the sponges was characterized by FTIR and SEM. The swelling ability, in vitro drug release and degradation behaviors, and an in vivo animal test were employed to confirm the applicability of this sponge as a wound dressing material. As the chitosan content in the sponge decreased, the swelling ability decreased. All types of the sponges exhibited biodegradable properties. The release of curcumin from the sponges could be controlled by the crosslinking degree. Curcumin could be released from the sponges in an extended period for up to 20 days. An in vivo animal test using SD rat showed that sponge had better effect than cotton gauze, and adding curcumin into the sponge enhanced the therapeutic healing effect.
Dai
Mei
M
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
Zheng
Xiuling
X
Xu
Xu
X
Kong
Xiangye
X
Li
Xingyi
X
Guo
Gang
G
Luo
Feng
F
Zhao
Xia
X
Wei
Yu Quan
YQ
Qian
Zhiyong
Z
D000464:Alginates / Q000494:pharmacology*; D000818:Animals; D048271:Chitosan / Q000494:pharmacology*; D003094:Collagen / Q000378:metabolism; D003474:Curcumin / Q000008:administration & dosage* / Q000494:pharmacology*; D020405:Dermis / Q000187:drug effects* / Q000473:pathology; D016503:Drug Delivery Systems / Q000379:methods*; D020723:Glucuronic Acid / Q000494:pharmacology; D006603:Hexuronic Acids / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D009113:Muramidase / Q000378:metabolism; D011161:Porifera; D051381:Rats; D017207:Rats, Sprague-Dawley; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D013194:Staining and Labeling; D013997:Time Factors; D014867:Water / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects*
D000464:Alginates; D006603:Hexuronic Acids; D012996:Solutions; D014867:Water; D020723:Glucuronic Acid; D003094:Collagen; D048271:Chitosan; D009113:Muramidase; D003474:Curcumin