Amino acid based enantiomerically pure 3-substituted benzofused heterocycles: A new class of antithrombotic agents.
A diverse group of novel medium ring heterocycles derived from naturally abundant proteinogenic amino acids were evaluated for their potency towards antithrombotic activity. The more potent benzofused oxazepine and oxazocine scaffolds were diversified by incorporating different amino acids at the position number 3. Further the effect of ring size has also been taken into account and it was observed that the eight-membered oxazocines ane more potent compared to the corresponding oxazepines.
Mishra
Jitendra Kumar
JK
Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, UP, India.
Samanta
Krishnananda
K
Jain
Manish
M
Dikshit
Madhu
M
Panda
Gautam
G
D000596:Amino Acids / Q000737:chemistry*; D001569:Benzodiazepines / Q000737:chemistry; D005343:Fibrinolytic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010077:Oxazepines / Q000737:chemistry; D010079:Oxazocines / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000596:Amino Acids; D005343:Fibrinolytic Agents; D006574:Heterocyclic Compounds, 2-Ring; D010077:Oxazepines; D010079:Oxazocines; D001569:Benzodiazepines