title: Surface activity of surfactant spiked with vitamin A.
abstract: BACKGROUND
  Intramuscular injections of vitamin A decrease the risk of broncho-pulmonary dysplasia. Admixture of vitamin A with surfactant as a lipophilic vehicle might be a less invasive modality.
  
  
  OBJECTIVE
  Test physical properties of surfactant + vitamin A.
  
  
  METHODS
  Miscibility and surface activity were tested in surfactant supplemented with retinyl-acetate, -palmitate, 13-cis-, or all-trans-retinoic acid.
  
  
  RESULTS
  Retinol acetate (5000 IU/mL) demonstrated miscibility with surfactant when premixing with ethanol. Its surface activity was 40% lower compared to surfactant alone.
  
  
  CONCLUSIONS
  These findings warrant preclinical studies to test whether administration of vitamin A in subjects requiring surfactant is associated with beneficial functional properties.
authors.affiliation: Division of Neonatology, Children's and Women's Health Centre of British Columbia, University of British Columbia, 4480 Oak Street, Vancouver, BC, Canada.
authors.forename: Vadim
authors.initials: V
authors.lastname: Bronshtein
authors.forename: Vugranam
authors.initials: V
authors.lastname: Venkatesh
authors.forename: Jas
authors.initials: J
authors.lastname: Aulakh
authors.forename: Philippe
authors.initials: P
authors.lastname: Chessex