title: Soluble receptor for advanced glycation end products in physiological and pathological pregnancy.
abstract: OBJECTIVE
  The receptor for advanced glycation end products, RAGE, has been implicated in pathogenesis of many diseases. Soluble RAGE, sRAGE, extracellular domain of RAGE, is new biomarker. The aim of the study was to determine sRAGE levels in physiological pregnancy and their changes in pregnancies complicated by preterm labor or preeclampsia.
  
  
  METHODS
  Serum levels of sRAGE were determined in 79 healthy pregnant women, 42 pregnant women in preterm labor or with preeclampsia and 24 non-pregnant controls.
  
  
  RESULTS
  sRAGE serum levels are decreased in physiological pregnancy compared to healthy non-pregnant controls (p<0.001). Serum sRAGE concentrations are higher in the 2nd trimester of physiological pregnancy, compared to the 1st and 3rd trimesters of pregnancy (p<0.001). sRAGE levels in women with preterm labor are decreased (p<0.05) and correlate negatively with the leukocyte count (r=-0.47, p<0.05). In women with preeclampsia, sRAGE is elevated (p<0.05) and correlates with serum creatinine concentration (r=0.54, p<0.05) and with uric acid concentration (r=0.51, p<0.05).
  
  
  CONCLUSIONS
  Our results clearly demonstrate significant differences in serum sRAGE levels in physiological pregnancy and in pathological states in pregnancy, however, further studies are required demonstrate the usefulness and significance of sRAGE.
authors.affiliation: Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
authors.forename: Anna
authors.initials: A
authors.lastname: Germanová
authors.forename: Michal
authors.initials: M
authors.lastname: Koucký
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Hájek
authors.forename: Antonín
authors.initials: A
authors.lastname: Parízek
authors.forename: Tomás
authors.initials: T
authors.lastname: Zima
authors.forename: Marta
authors.initials: M
authors.lastname: Kalousová
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007752:Obstetric Labor, Premature / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011264:Pregnancy Trimesters / Q000097:blood; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*; D012995:Solubility
chemical_list: D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic