Independent sets of DNA oligonucleotides for nanotechnology applications.
Independent sets of DNA oligonucleotides, which only bind with their Watson-Crick complements, have potential use in self-assembly of nanostructures, since they minimize errors and inefficiency from unwanted binding. A software tool implemented a thermodynamic model for DNA duplex formation and was used to generate large independent sets of DNA oligonucleotides. The principle of the approach was experimentally verified on a sample set of oligonucleotides.
Yu
Weixia
W
Department of Computer Science and Computer Engineering, University of Arkansas, Fayetteville, AR 72701, USA. wxyu@ucla.edu
Lee
Ju Seok
JS
Johnson
Cole
C
Kim
Jin-Woo
JW
Deaton
Russell
R
D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D008957:Models, Genetic; D036103:Nanotechnology / Q000379:methods*; D009693:Nucleic Acid Hybridization / Q000379:methods*; D009841:Oligonucleotides / Q000737:chemistry / Q000378:metabolism; D015203:Reproducibility of Results; D012984:Software; D013816:Thermodynamics
D009841:Oligonucleotides; D004247:DNA