The Glucosafe system for tight glycemic control in critical care: a pilot evaluation study.
OBJECTIVE
"Glucosafe' is a new model-based decision support system for glycemic control in critical care. Safety and achievement of glycemic goals using the system are tested prospectively.


METHODS
Four penalty functions were developed to balance regimens of nutrition and insulin therapy against model-predicted glycemic outcome. The system advises the regimen where the penalty sum is minimal. An interactive interface allows advice alterations. Ten hyperglycemic patients (median Acute Physiology and Chronic Health Evaluation II, 12.5; interquartile range, 7.5-16.3) from a neuro and trauma intensive care unit were included for pilot testing using Glucosafe for 12 to 14 hours. Glycemic outcomes were compared to the 24-hour intervals before and after intervention.


RESULTS
Hypoglycemia (blood glucose [BG] <3.5 mmol/L) was not observed. Mean log-normal BG +/- standard deviation was reduced from 8.6 +/- 2.4 mmol/L preintervention to 7.0 +/- 1.1 mmol/L during the intervention. Nine patients reached the 4.4- to 6.1-mmol/L band after a mean 5 hours. At 5 hours intervention, mean log-normal BG was 6.7 mmol/L, 40% of measurements were in the 4.4- to 6.1-mmol/L band, and 84% were in the 4.4- to 7.75-mmol/L band.


CONCLUSIONS
Safety was demonstrated with the developed penalty functions. The low BG variance achieved may permit minor adjustments of the penalty function values to reduce average BG if desired.
Pielmeier
Ulrike
U
Center for Model-based Medical Decision Support, Aalborg University, 9220 Aalborg, Denmark. upiel@hst.aau.dk
Andreassen
Steen
S
Juliussen
Brian
B
Chase
J Geoffrey
JG
Nielsen
Birgitte Steenfeldt
BS
Haure
Pernille
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis; D003422:Critical Care / Q000379:methods*; D020000:Decision Support Systems, Clinical; D004867:Equipment Design; D004869:Equipment Safety; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D016896:Treatment Outcome; D014584:User-Computer Interface
D001786:Blood Glucose