title: Bilateral injection-site granuloma by subcutaneous administration of luteinizing hormone-releasing hormone analogue: a case report.
abstract: We report a typical case of injection-site granuloma attributed to subcutaneous administration of leuprorelin acetate, an LHRH agonist. A 70-year-old man who had undergone total prostatectomy and was subsequently given leuprorelin injections for prostatic cancer presented with bilateral nodules in the lower abdominal wall. An excisional biopsy revealed a non-caseous epithelioid granuloma consisting of CD-68 positive histiocytic cells with infiltration of T-lymphocytes and eosinophils; skin metastasis from prostatic adenocarcinoma was ruled out through histological and immunohistochemical analysis. Generally, granulomas may be caused by delayed-type hypersensitivity to the constituents of leuprorelin acetate injections.
authors.affiliation: Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cyo,Chuo-ku, Kobe 650-0017, Japan. riko@med.kobe-u.ac.jp
authors.forename: Riko
authors.initials: R
authors.lastname: Kitazawa
authors.forename: Fukashi
authors.initials: F
authors.lastname: Yamamichi
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Hidaka
authors.forename: Shinichi
authors.initials: S
authors.lastname: Morishita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kondo
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Mori
authors.forename: Sohei
authors.initials: S
authors.lastname: Kitazawa