Vaccines against tularemia.
Francisella tularensis is a Category A select agent for which vaccine and countermeasure development are a priority. In the past eight years, renewed interest in this pathogen has led to the generation of an enormous amount of new data on both the pathogen itself and its interaction with host cells. This information has fostered the development of various vaccine candidates including acellular subunit, killed whole cell and live attenuated. This review summarizes the progress and promise of these various candidates.
Barry
Eileen M
EM
University of Maryland School of Medicine, Center for Vaccine Development, Baltimore, MD, USA. ebarry@medicine.umaryland.edu
Cole
Leah E
LE
Santiago
Araceli E
AE
D001428:Bacterial Vaccines / Q000276:immunology*; D023482:Bioterrorism; D005604:Francisella tularensis / Q000276:immunology*; D006801:Humans; D014406:Tularemia / Q000517:prevention & control*; D022282:Vaccines, Acellular / Q000276:immunology; D014613:Vaccines, Attenuated / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology
D001428:Bacterial Vaccines; D022282:Vaccines, Acellular; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated