[Change in the content of lipid-soluble antioxidants in animals with Walker-256 carcinosarcoma exposed to different therapies].
The time course of changes in the content of lipid-soluble antioxidants in the sera of male Wistar rats with transplantable Walker-256 carcinosarcoma in the application of controlled systemic hyperthermia, cyclophosphan, and melatonin were studied. When controlled systemic hyperthermia and cyclophosphan were used, the rat serum levels of alpha-tocopherol and retinol reduced whereas the addition of melatonin to therapy unchanged their content. Therefore, one of the promising ways of increasing the efficiency of treatment for malignancies may be to maintain the high activity of the antioxidant regulation system in nonneoplastic cells and tissues.
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D002279:Carcinoma 256, Walker / Q000097:blood* / Q000628:therapy*; D003520:Cyclophosphamide / Q000494:pharmacology; D006979:Hyperthermia, Induced; D008297:Male; D008550:Melatonin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014801:Vitamin A / Q000097:blood*; D024502:alpha-Tocopherol / Q000097:blood*
D018906:Antineoplastic Agents, Alkylating; D000975:Antioxidants; D014801:Vitamin A; D003520:Cyclophosphamide; D024502:alpha-Tocopherol; D008550:Melatonin