Portable optical tissue flow oximeter based on diffuse correlation spectroscopy.
A portable diffuse correlation spectroscopy (DCS) flowmeter has been extended to measure both tissue blood flow and oxygenation (namely, DCS flow oximeter). For validation purposes, calf muscle blood oxygenation during cuff inflation and deflation was measured concurrently using the DCS flow oximeter and a commercial tissue oximeter. The oxygenation traces from the two measurements exhibited similar dynamic responses, and data were highly correlated (r(mean)>0.9, P<10(-5), n=10). The portable, inexpensive, and easy-to-use DCS flow oximeter holds promise for bedside monitoring of tissue blood flow and oxygenation in clinics.
Shang
Yu
Y
Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506, USA.
Zhao
Youquan
Y
Cheng
Ran
R
Dong
Lixin
L
Irwin
Daniel
D
Yu
Guoqiang
G
D000818:Animals; D002417:Cattle; D004058:Diffusion; D004912:Erythrocytes / Q000378:metabolism; D009068:Movement; D055096:Optical Devices; D010092:Oximetry / Q000295:instrumentation* / Q000379:methods; D010100:Oxygen / Q000378:metabolism; D012039:Regional Blood Flow; D013057:Spectrum Analysis
D010100:Oxygen