title: Preparation of MPEG-PLA nanoparticle for honokiol delivery in vitro.
abstract: Honokiol (HK) shows potential application in cancer treatment, but its poor water solubility restricts clinical application greatly. In this paper, monomethoxy poly(ethylene glycol)-poly(lactic acid) (MPEG-PLA) was synthesized by ring-opening polymerization and processed into nanoparticle for honokiol delivery. Chemical structure of the synthesized polymer was confirmed by (1)H NMR, and its molecular weight was determined by gel permeation chromatography (GPC). Honokiol loaded MPEG-PLA nanoparticles were prepared by solvent extract method. And particle size distribution, morphology, drug loading, drug release profile and anticancer activity in vitro were studied in detail. The described honokiol loaded MPEG-PLA nanoparticles in this paper might be a novel formulation for honokiol delivery.
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China.
authors.forename: XiuLing
authors.initials: X
authors.lastname: Zheng
authors.forename: Bing
authors.initials: B
authors.lastname: Kan
authors.forename: MaLing
authors.initials: M
authors.lastname: Gou
authors.forename: ShaoZhi
authors.initials: S
authors.lastname: Fu
authors.forename: Juan
authors.initials: J
authors.lastname: Zhang
authors.forename: Ke
authors.initials: K
authors.lastname: Men
authors.forename: LiJuan
authors.initials: L
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Luo
authors.forename: YingLan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
authors.forename: YuQuan
authors.initials: Y
authors.lastname: Wei
authors.forename: ZhiYong
authors.initials: Z
authors.lastname: Qian
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D002850:Chromatography, Gel; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D005260:Female; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D017705:Lignans / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D008970:Molecular Weight; D053758:Nanoparticles; D036103:Nanotechnology; D010051:Ovarian Neoplasms / Q000473:pathology; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry* / Q000633:toxicity; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000633:toxicity; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001713:Biphenyl Compounds; D004337:Drug Carriers; D017705:Lignans; D011091:Polyesters; D011092:Polyethylene Glycols; D012997:Solvents; C492425:methoxy poly(ethylene glycol)-poly(lactide); C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols