title: Acute alcohol impairs conditioning of a behavioural reward-seeking response and inhibitory control processes--implications for addictive disorders.
abstract: OBJECTIVE
  To investigate whether acute alcohol would affect performance of a conditioned behavioural response to obtain a reward outcome and impair performance in a task measuring inhibitory control to provide new knowledge of how the acute effects of alcohol might contribute to the transition from alcohol use to dependence.
  
  
  METHODS
  A randomized controlled between-subjects design was employed.
  
  
  METHODS
  The laboratory of experimental psychology at the University of Sussex.
  
  
  METHODS
  Thirty-two light to moderate social drinkers recruited from the undergraduate and postgraduate population.
  
  
  METHODS
  After the administration of alcohol (0.8 g/kg) or placebo participants underwent an instrumental reward-seeking procedure, with abstract stimuli serving as S+ (always predicting a win of 10 pence) and S- (always predicting a loss of 10 pence). In addition, a Stop Signal task was administered before and after the administration of alcohol.
  
  
  RESULTS
  Participants of the alcohol group performed the behavioural response to obtain the reward outcome more often than placebo subjects in trials associated with loss of money. This finding was observed, although alcohol was not affecting explicit knowledge of stimulus-response outcome contingencies and acquisition of conditioned attentional and emotional responses. In addition, alcohol increased Stop Signal reaction time indicating disinhibiting effects of alcohol, and this was associated positively with response probability to the S-.
  
  
  CONCLUSIONS
  These results demonstrate that alcohol is affecting inhibitory control of behavioural responses to external signals even when associated with punishment, contributing in this way to the transition from alcohol use to dependence.
authors.affiliation: Department of Addictive Behavior and Addiction Medicine, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Loeber
authors.forename: Theodora
authors.initials: T
authors.lastname: Duka
mesh_terms: D000293:Adolescent; D000339:Affect / Q000502:physiology; D000428:Alcohol Drinking / Q000523:psychology*; D019973:Alcohol-Related Disorders / Q000209:etiology; D016022:Case-Control Studies; D003213:Conditioning, Psychological / Q000502:physiology; D000431:Ethanol / Q000097:blood*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D011930:Reaction Time / Q000502:physiology; D012201:Reward; D013647:Task Performance and Analysis; D014796:Visual Perception / Q000502:physiology; D055815:Young Adult
chemical_list: D000431:Ethanol