Ca(2+)-modulated membrane guanylate cyclase in the testes.
To date, the calcium-regulated membrane guanylate cyclase Rod Outer Segment Guanylate Cyclase type 1 (ROS-GC1) transduction system in addition to photoreceptors is known to be expressed in three other types of neuronal cells: in the pinealocytes, mitral cells of the olfactory bulb and the gustatory epithelium of tongue. Very recent studies from our laboratory show that expression of ROS-GC1 is not restricted to the neuronal cells; the male gonads and the spermatozoa also express ROS-GC1. In this presentation, the authors review the existing information on the localization and function of guanylate cyclase with special emphasis on Ca(2+)-modulated membrane guanylate cyclase, ROS-GC1, in the testes. The role of ROS-GC1 and its Ca(2+)-sensing modulators in the processes of spermatogenesis and fertilization are discussed.
Jankowska
Anna
A
Department of Cell Biology, Poznan University of Medical Sciences, Rokietnicka 5D, 60-806 Poznan, Poland. ajanko@ump.edu.pl
Warchol
Jerzy B
JB
D000818:Animals; D020013:Calcium Signaling; D005306:Fertilization; D006162:Guanylate Cyclase / Q000502:physiology*; D006801:Humans; D008297:Male; D011956:Receptors, Cell Surface / Q000502:physiology*; D012098:Reproduction; D013091:Spermatogenesis; D013737:Testis / Q000201:enzymology*
D011956:Receptors, Cell Surface; C110715:guanylate cyclase 1; D006162:Guanylate Cyclase