title: Common variants at five new loci associated with early-onset inflammatory bowel disease.
abstract: The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset IBD.
authors.affiliation: Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
authors.forename: Marcin
authors.initials: M
authors.lastname: Imielinski
authors.forename: Robert N
authors.initials: RN
authors.lastname: Baldassano
authors.forename: Anne
authors.initials: A
authors.lastname: Griffiths
authors.forename: Richard K
authors.initials: RK
authors.lastname: Russell
authors.forename: Vito
authors.initials: V
authors.lastname: Annese
authors.forename: Marla
authors.initials: M
authors.lastname: Dubinsky
authors.forename: Subra
authors.initials: S
authors.lastname: Kugathasan
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Bradfield
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Walters
authors.forename: Patrick
authors.initials: P
authors.lastname: Sleiman
authors.forename: Cecilia E
authors.initials: CE
authors.lastname: Kim
authors.forename: Aleixo
authors.initials: A
authors.lastname: Muise
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Glessner
authors.forename: Shehzad
authors.initials: S
authors.lastname: Saeed
authors.forename: Haitao
authors.initials: H
authors.lastname: Zhang
authors.forename: Edward C
authors.initials: EC
authors.lastname: Frackelton
authors.forename: Cuiping
authors.initials: C
authors.lastname: Hou
authors.forename: James H
authors.initials: JH
authors.lastname: Flory
authors.forename: George
authors.initials: G
authors.lastname: Otieno
authors.forename: Rosetta M
authors.initials: RM
authors.lastname: Chiavacci
authors.forename: Robert
authors.initials: R
authors.lastname: Grundmeier
authors.forename: Massimo
authors.initials: M
authors.lastname: Castro
authors.forename: Anna
authors.initials: A
authors.lastname: Latiano
authors.forename: Bruno
authors.initials: B
authors.lastname: Dallapiccola
authors.forename: Joanne
authors.initials: J
authors.lastname: Stempak
authors.forename: Debra J
authors.initials: DJ
authors.lastname: Abrams
authors.forename: Kent
authors.initials: K
authors.lastname: Taylor
authors.forename: Dermot
authors.initials: D
authors.lastname: McGovern
authors.forename: Gary
authors.initials: G
authors.lastname: Silber
authors.forename: Iwona
authors.initials: I
authors.lastname: Wrobel
authors.forename: Antonio
authors.initials: A
authors.lastname: Quiros
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Barrett
authors.forename: Sarah
authors.initials: S
authors.lastname: Hansoul
authors.forename: Dan L
authors.initials: DL
authors.lastname: Nicolae
authors.forename: Judy H
authors.initials: JH
authors.lastname: Cho
authors.forename: Richard H
authors.initials: RH
authors.lastname: Duerr
authors.forename: John D
authors.initials: JD
authors.lastname: Rioux
authors.forename: Steven R
authors.initials: SR
authors.lastname: Brant
authors.forename: Mark S
authors.initials: MS
authors.lastname: Silverberg
authors.forename: Kent D
authors.initials: KD
authors.lastname: Taylor
authors.forename: M Michael
authors.initials: MM
authors.lastname: Barmuda
authors.forename: Alain
authors.initials: A
authors.lastname: Bitton
authors.forename: Themistocles
authors.initials: T
authors.lastname: Dassopoulos
authors.forename: Lisa Wu
authors.initials: LW
authors.lastname: Datta
authors.forename: Todd
authors.initials: T
authors.lastname: Green
authors.forename: Anne M
authors.initials: AM
authors.lastname: Griffiths
authors.forename: Emily O
authors.initials: EO
authors.lastname: Kistner
authors.forename: Michael T
authors.initials: MT
authors.lastname: Murtha
authors.forename: Miguel D
authors.initials: MD
authors.lastname: Regueiro
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.forename: L Philip
authors.initials: LP
authors.lastname: Schumm
authors.forename: A Hillary
authors.initials: AH
authors.lastname: Steinhart
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Targan
authors.forename: Ramnik J
authors.initials: RJ
authors.lastname: Xavier
authors.forename: Cécile
authors.initials: C
authors.lastname: Libioulle
authors.forename: Cynthia
authors.initials: C
authors.lastname: Sandor
authors.forename: Mark
authors.initials: M
authors.lastname: Lathrop
authors.forename: Jacques
authors.initials: J
authors.lastname: Belaiche
authors.forename: Olivier
authors.initials: O
authors.lastname: Dewit
authors.forename: Ivo
authors.initials: I
authors.lastname: Gut
authors.forename: Simon
authors.initials: S
authors.lastname: Heath
authors.forename: Debby
authors.initials: D
authors.lastname: Laukens
authors.forename: Myriam
authors.initials: M
authors.lastname: Mni
authors.forename: Paul
authors.initials: P
authors.lastname: Rutgeerts
authors.forename: André
authors.initials: A
authors.lastname: Van Gossum
authors.forename: Diana
authors.initials: D
authors.lastname: Zelenika
authors.forename: Denis
authors.initials: D
authors.lastname: Franchimont
authors.forename: J P
authors.initials: JP
authors.lastname: Hugot
authors.forename: Martine
authors.initials: M
authors.lastname: de Vos
authors.forename: Severine
authors.initials: S
authors.lastname: Vermeire
authors.forename: Edouard
authors.initials: E
authors.lastname: Louis
authors.forename: Lon R
authors.initials: LR
authors.lastname: Cardon
authors.forename: Carl A
authors.initials: CA
authors.lastname: Anderson
authors.forename: Hazel
authors.initials: H
authors.lastname: Drummond
authors.forename: Elaine
authors.initials: E
authors.lastname: Nimmo
authors.forename: Tariq
authors.initials: T
authors.lastname: Ahmad
authors.forename: Natalie J
authors.initials: NJ
authors.lastname: Prescott
authors.forename: Clive M
authors.initials: CM
authors.lastname: Onnie
authors.forename: Sheila A
authors.initials: SA
authors.lastname: Fisher
authors.forename: Jonathan
authors.initials: J
authors.lastname: Marchini
authors.forename: Jilur
authors.initials: J
authors.lastname: Ghori
authors.forename: Suzannah
authors.initials: S
authors.lastname: Bumpstead
authors.forename: Rhian
authors.initials: R
authors.lastname: Gwillam
authors.forename: Mark
authors.initials: M
authors.lastname: Tremelling
authors.forename: Panos
authors.initials: P
authors.lastname: Delukas
authors.forename: John
authors.initials: J
authors.lastname: Mansfield
authors.forename: Derek
authors.initials: D
authors.lastname: Jewell
authors.forename: Jack
authors.initials: J
authors.lastname: Satsangi
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Mathew
authors.forename: Miles
authors.initials: M
authors.lastname: Parkes
authors.forename: Michel
authors.initials: M
authors.lastname: Georges
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Daly
authors.forename: Melvin B
authors.initials: MB
authors.lastname: Heyman
authors.forename: George D
authors.initials: GD
authors.lastname: Ferry
authors.forename: Barbara
authors.initials: B
authors.lastname: Kirschner
authors.forename: Jessica
authors.initials: J
authors.lastname: Lee
authors.forename: Jonah
authors.initials: J
authors.lastname: Essers
authors.forename: Richard
authors.initials: R
authors.lastname: Grand
authors.forename: Michael
authors.initials: M
authors.lastname: Stephens
authors.forename: Arie
authors.initials: A
authors.lastname: Levine
authors.forename: David
authors.initials: D
authors.lastname: Piccoli
authors.forename: John
authors.initials: J
authors.lastname: Van Limbergen
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cucchiara
authors.forename: Dimitri S
authors.initials: DS
authors.lastname: Monos
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Guthery
authors.forename: Lee
authors.initials: L
authors.lastname: Denson
authors.forename: David C
authors.initials: DC
authors.lastname: Wilson
authors.forename: Straun F A
authors.initials: SF
authors.lastname: Grant
authors.forename: Mark
authors.initials: M
authors.lastname: Daly
authors.forename: Mark S
authors.initials: MS
authors.lastname: Silverberg
authors.forename: Jack
authors.initials: J
authors.lastname: Satsangi
authors.forename: Hakon
authors.initials: H
authors.lastname: Hakonarson
mesh_terms: D017668:Age of Onset; D002874:Chromosome Mapping; D003093:Colitis, Ulcerative / Q000235:genetics; D014644:Genetic Variation; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology / Q000235:genetics*