title: Does gastroesophageal reflux contribute to development of acquired nasolacrimal duct obstruction?
abstract: Primary acquired nasolacrimal duct obstruction results from inflammation of unknown cause that eventually leads to fibrosis and occlusion. The nasolacrimal duct is within the medial wall of maxillary sinus and open into the nasal cavity. It may be affected by gasteroesophageal reflux disease (GERD) by the possible direct noxious effect of the refluxate on the nasal mucosal cavity surrounding of the nasolacrimal duct opening at the inferior meatous and ascending of inflammation to the mucosa of the duct may leads to chronic inflammation and fibrosis. In addition to, the GERD may induce autonomic nervous system hyperactivity resulting in hyperemia of venous plexus surrounding nasolacrimal duct leading to secondary mucosal edema of nasolacrimal duct and dacryostenosis.
authors.affiliation: Dept of Ophthalmology, Shiraz University of Medical Sciences, Khallili Hospital, Shiraz 7193616641, Iran. owjin@sums.ac.ir
authors.forename: Naser
authors.initials: N
authors.lastname: Owji
authors.forename: Seyed Mohammad Bagher
authors.initials: SM
authors.lastname: Abtahi
mesh_terms: D005764:Gastroesophageal Reflux / Q000150:complications* / Q000503:physiopathology*; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000209:etiology* / Q000503:physiopathology*; D008954:Models, Biological; D009301:Nasolacrimal Duct / Q000503:physiopathology*; D009831:Olfactory Mucosa / Q000503:physiopathology*