title: Reliability of the bright liver echo pattern in diagnosing steatosis in patients with cryptogenic and HCV-related hypertransaminasaemia.
abstract: OBJECTIVE
  To evaluate the reliability of the bright liver (BL) echo pattern on ultrasound to detect histological steatosis in chronic cryptogenic hypertransaminasaemia (CCH) and hepatitis C virus (HCV)-related forms of hypertransaminasaemia.
  
  
  METHODS
  One hundred and fifty patients, 54 with CCH and 96 with HCV hypertransaminasaemia (76 genotype 1/2 and 20 genotype 3), were enrolled. Histological steatosis was measured as the percentage of hepatocytes involved. The reliability of the BL sign was estimated using the sensitivity, specificity, positive and negative predictive values.
  
  
  RESULTS
  Histological steatosis was present in 102/150 patients (68%) divided into 59/96 (62%) in the HCV group and 43/54 (79.6%) in the CCH group (chi(2)=4.4; p=0.035). In a multivariate analysis, the variable associated with the BL echo pattern was steatosis percentage (p=0.0018). Steatosis percentage was higher in CCH group than in the HCV genotype 1/2 and 3 groups (p=0.02). The sensitivity of the BL echo pattern was 88% in the CCH group [confidence interval (CI) 95% 74-95] versus 61% (CI 95% 44-73) in the HCV genotype 1/2 group. The CI indicates that ultrasound can provide evidence for steatosis in a statistically significant way in the CCH versus HCV genotype 1/2 patients. In the genotype 3 group, the sensitivity was high (90%), but the limited number of cases limited the statistical significance due to the high CI.
  
  
  CONCLUSIONS
  In CCH the BL echo pattern has excellent reliability in diagnosing steatosis, better than in HCV hypertransaminasaemia because of the higher prevalence and extent of steatosis.
authors.affiliation: Department of Clinical Medicine and Emerging Pathologies, University of Palermo, Palermo, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Soresi
authors.forename: L
authors.initials: L
authors.lastname: Giannitrapani
authors.forename: A M
authors.initials: AM
authors.lastname: Florena
authors.forename: E
authors.initials: E
authors.lastname: La Spada
authors.forename: V
authors.initials: V
authors.lastname: Di Gesaro
authors.forename: F
authors.initials: F
authors.lastname: Rappa
authors.forename: A
authors.initials: A
authors.lastname: Alessandri
authors.forename: S
authors.initials: S
authors.lastname: Tripi
authors.forename: M
authors.initials: M
authors.lastname: Romano
authors.forename: G
authors.initials: G
authors.lastname: Montalto
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005234:Fatty Liver / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005260:Female; D006526:Hepatitis C / Q000150:complications; D006521:Hepatitis, Chronic / Q000150:complications; D022781:Hepatocytes / Q000821:virology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008099:Liver / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D000637:Transaminases / Q000097:blood; D018615:Ultrasonography, Doppler, Color / Q000379:methods*
chemical_list: D015415:Biomarkers; D000637:Transaminases