title: [Malignant hyperthermia--diagnostics, treatment and anaesthetic management].
abstract: In malignant hyperthermia (MH) susceptible individuals volatile anaesthetics and the depolarizing muscle relaxant succinylcholine may induce a potentially lethal hypermetabolic syndrome of skeletal muscle due to an uncontrolled sarcoplasmic calcium release. Immediate discontinuation of triggering agents, oxygenation, correction of acidosis and electrolyte abnormalities and dantrolene application are essential for MH treatment. This article reviews the clinical symptoms of MH, the diagnostic criteria and the actual guidelines for treatment and management of anaesthesia in susceptible individuals.
authors.affiliation: Klinik und Poliklinik für Anästhesiologie, Universitätsklinikums Würzburg. schuster_f@klinik.uni-wuerzburg.de
authors.forename: Frank
authors.initials: F
authors.lastname: Schuster
authors.forename: Clemens R
authors.initials: CR
authors.lastname: Müller-Reible
mesh_terms: D000758:Anesthesia; D000765:Anesthesia, Conduction; D001706:Biopsy; D006801:Humans; D008305:Malignant Hyperthermia / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D018482:Muscle, Skeletal / Q000473:pathology