title: Sensory-motor axonal peripheral neuropathy in an advanced breast cancer patient treated with ixabepilone.
abstract: Ixabepilone is a novel microtubule-stabilising agent used as monotherapy or in combination with capecitabine to treat taxane- and anthracycline-refractory breast cancer. We report the case of a patient who experienced an unusual motor neuropathy after the first cycle. This is a very uncommon secondary effect, but it must be taken into account as a possible complication of treatment with ixabepilone.
authors.affiliation: Department of Oncology, Clínica Universidad de Navarra, Pamplona, Navarra, Spain. jbosch@unav.es
authors.forename: Joaquim
authors.initials: J
authors.lastname: Bosch-Barrera
authors.forename: Jaime
authors.initials: J
authors.lastname: Espinós
authors.forename: Asier
authors.initials: A
authors.lastname: Gómez-Ibáñez
authors.forename: Jaime
authors.initials: J
authors.lastname: Gállego Pérez-Larraya
authors.forename: Jorge
authors.initials: J
authors.lastname: Iriarte
mesh_terms: D001369:Axons / Q000378:metabolism*; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy*; D034261:Epothilones / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D008875:Middle Aged; D009475:Neurons, Afferent / Q000187:drug effects* / Q000378:metabolism*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D016896:Treatment Outcome; D050257:Tubulin Modulators / Q000009:adverse effects
chemical_list: D034261:Epothilones; D050257:Tubulin Modulators; C430592:ixabepilone