[Role of antimicrobial peptides (AMP) and pattern recognition receptors (PRR) in the intestinal mucosa homeostasis].
Homeostasis and integrity of bowel mucosa is assured by well controlled mechanical, biochemical and immunological mechanisms. First line of defense is presented by the antimicrobial peptides (AMP), which form a continuous layer on the bowel surface, produced by intestinal specific (Paneth) and non-specific epithelial cells. AMPs have a significant antimicrobial, antifungal and antiviral, as well as immunomodulatory effects. Next line of defense is the pattern recognition receptors (PRR), which allows identifying conservative molecular patterns of different pathogens, and starts antimicrobial and inflammatory mechanisms through gene-expression induction. We review the most recent knowledge and studies concerning these mechanisms.
Lapis
Károly
K
Semmelweis Egyetem, Altalános Orvostudományi Kar I. Patológiai és Kísérleti Rákkutató Intézet Budapest Ulloi út 26. 1085. klapis@korb1.sote.hu
D000935:Antifungal Agents / Q000378:metabolism; D023181:Antimicrobial Cationic Peptides / Q000276:immunology / Q000378:metabolism*; D000998:Antiviral Agents / Q000378:metabolism; D005786:Gene Expression Regulation; D006706:Homeostasis / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism*; D051192:Receptors, Pattern Recognition / Q000276:immunology / Q000378:metabolism*
D000935:Antifungal Agents; D023181:Antimicrobial Cationic Peptides; D000998:Antiviral Agents; D051192:Receptors, Pattern Recognition