title: Effects of sepsis on the neuromuscular blocking actions of d-tubocurarine on rat adductor and abductor laryngeal muscles.
abstract: OBJECTIVE
  We evaluated the effects of sepsis on the neuromuscular blocking actions of d-tubocurarine (dTc) in the lateral cricoarytenoid (LCA) and posterior cricoarytenoid (PCA) muscles, an adductor muscle and an abductor muscle of the vocal cords, respectively, in vitro.
  
  
  METHODS
  Sepsis was induced in rats by cecal ligation and puncture (CLP) to elicit panperitonitis. Electromyograms (EMGs) and endplate potentials (EPPs) were recorded from the LCA and PCA muscles of CLP-operated septic rats and sham-operated nonseptic rats, using extracellular and intracellular microelectrodes, respectively.
  
  
  RESULTS
  EMG and EPP (amplitude and quantum content) were depressed by dTc, but the dTc-induced neuromuscular blocking effects were attenuated by sepsis. The suppressive effects of dTc on EMG and EPP (amplitude and quantum content) were less intense in the LCA muscle than in the PCA muscle under both sepsis and nonsepsis conditions.
  
  
  CONCLUSIONS
  Our study shows that sepsis has a depressive effect on dTc-induced neuromuscular blocking actions at both the adductor and abductor muscles of vocal cords in the larynx.
authors.affiliation: Department of Anesthesiology, Sapporo Medical University, School of Medicine, Sapporo, Japan.
authors.forename: Kohki
authors.initials: K
authors.lastname: Nishikawa
authors.forename: Eichi
authors.initials: E
authors.lastname: Narimatsu
authors.forename: Motohiko
authors.initials: M
authors.lastname: Igarashi
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Namiki
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004558:Electric Stimulation; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000187:drug effects; D066298:In Vitro Techniques; D007821:Laryngeal Muscles / Q000187:drug effects*; D008297:Male; D008839:Microelectrodes; D009045:Motor Endplate / Q000187:drug effects; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000503:physiopathology*; D014403:Tubocurarine / Q000494:pharmacology*
chemical_list: D009466:Neuromuscular Blocking Agents; D003473:Neuromuscular Nondepolarizing Agents; D014403:Tubocurarine