title: Dietary antioxidant capacity and concentration of adiponectin in apparently healthy adults: the ATTICA study.
abstract: OBJECTIVE
  This study aimed at evaluating the relationship of adiponectin concentration with total dietary antioxidant capacity in free-living, apparently healthy adults from the ATTICA study.
  
  
  METHODS
  A random subsample from the ATTICA study, consisting of 310 men (40+/-11 years) and 222 women (38+/-12 years), was selected. Adiponectin, along with other inflammatory markers, was measured in fasting participants. Dietary habits were evaluated using a food frequency questionnaire and the dietary antioxidant capacity was based on published values of Italian foods measured by three different assays: ferric-reducing antioxidant power (FRAP), total radical-trapping antioxidant parameters (TRAP) and trolox-equivalent antioxidant capacity (TEAC).
  
  
  RESULTS
  Positive associations were observed between dietary antioxidant capacity and adiponectin concentration, as assessed with FRAP (b+/-s.e.=0.012+/-0.005, P=0.018 per 1 mmol Fe (II)/day), TRAP (b+/-s.e.=0.030+/-0.013, P=0.017 per 1 mmol trolox equivalent/day) and TEAC (b+/-s.e.=0.025+/-0.012, P=0.042, per 1 mmol trolox equivalent/day) in multiadjusted analysis. Moreover, a negative relation of dietary antioxidant indices with inflammatory markers was revealed.
  
  
  CONCLUSIONS
  Diets with high antioxidant capacity are related to increased adiponectin levels. An adiponectin-mediated route through which antioxidant-rich foods exert beneficial effects against inflammation and cardiovascular diseases can be thus hypothesized.
authors.affiliation: Department of Nutrition-Dietetics, Harokopio University, Athens, Greece.
authors.forename: P
authors.initials: P
authors.lastname: Detopoulou
authors.forename: D B
authors.initials: DB
authors.lastname: Panagiotakos
authors.forename: C
authors.initials: C
authors.lastname: Chrysohoou
authors.forename: E
authors.initials: E
authors.lastname: Fragopoulou
authors.forename: T
authors.initials: T
authors.lastname: Nomikos
authors.forename: S
authors.initials: S
authors.lastname: Antonopoulou
authors.forename: C
authors.initials: C
authors.lastname: Pitsavos
authors.forename: C
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D004034:Diet Surveys; D038441:Diet, Mediterranean; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007558:Italy; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D011795:Surveys and Questionnaires
chemical_list: D052242:Adiponectin; D000975:Antioxidants; D015415:Biomarkers; D018836:Inflammation Mediators