Ghost cell odontogenic carcinoma arising in calcifying odontogenic cyst.
A case of exceptionally rare odontogenic malignant tumor, called ghost cell odontogenic carcinoma, is described. The tumor was considered to be derived from calcifying odontogenic cyst, which had been resected 5 years before. In the present resected specimen, cellular atypia, mitotic activity, Ki-67 labeling index, and p53 positivity were all increased in comparison with the initially resected specimen. This is a valuable case in which malignant transformation from calcifying odontogenic cyst to ghost cell odontogenic carcinoma was proven by the histopathologic and immunohistochemical findings. Pathologists should be aware of this rare entity.
Motosugi
Utaroh
U
Department of Pathology, Saitama Medical University International Medical Center, Saitama 350-1298, Japan. utaroh-motosugi@nifty.com
Ogawa
Ikuko
I
Yoda
Tetsuya
T
Abe
Takahiro
T
Sugasawa
Masashi
M
Murata
Shin-ichi
S
Yasuda
Masanori
M
Sakurai
Takaki
T
Shimizu
Yoshihiko
Y
Shimizu
Michio
M
D000293:Adolescent; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008441:Maxillary Neoplasms / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009808:Odontogenic Tumors / Q000473:pathology*; D016159:Tumor Suppressor Protein p53
D016159:Tumor Suppressor Protein p53