Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder.
Pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1: adenylate cyclase-activating polypeptide 1) is a neuropeptide with neurotransmission modulating activity. The associations of the PACAP gene with schizophrenia and hippocampal volume have been reported. We recently reported depression-like behavior in the forced swimming test in PACAP deficient mice. Here we examined a possible association between the PACAP gene and major depressive disorder (MDD) in 637 patients and 967 controls and found that a genetic variant in the gene was associated with MDD. The present results suggest that PACAP signaling might contribute to the pathogenesis of MDD.
Hashimoto
Ryota
R
The Osaka-Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan. hashimor@psy.med.osaka-u.ac.jp
Hashimoto
Hitoshi
H
Shintani
Norihito
N
Ohi
Kazutaka
K
Hori
Hiroaki
H
Saitoh
Osamu
O
Kosuga
Asako
A
Tatsumi
Masahiko
M
Iwata
Nakao
N
Ozaki
Norio
N
Kamijima
Kunitoshi
K
Baba
Akemichi
A
Takeda
Masatoshi
M
Kunugi
Hiroshi
H
D000328:Adult; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
C495401:ADCYAP1 protein, human; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide