Role of CSF-1 in progression of epithelial ovarian cancer.
Despite the dismal outcome seen in the majority of epithelial ovarian cancer patients, there is ongoing progress in understanding the disease at a molecular level. Elucidation of pathways underlying disease progression and metastasis of ovarian cancer is key to development of targeted therapeutics. It is only in this way that therapeutic potential can be translated to reality. Here, we describe the evidence to date for the role of CSF-1/c-fms signaling in ovarian cancer invasiveness and metastasis, including the recent understanding of how CSF-1/c-fms expression is regulated with identification of significant post-transcriptional regulators.
Chambers
Setsuko K
SK
Women's Cancers, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA. schambers@azcc.arizona.edu
D018450:Disease Progression; D005260:Female; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000502:physiology*; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism / Q000503:physiopathology*; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000503:physiopathology*; D015398:Signal Transduction
D016173:Macrophage Colony-Stimulating Factor