title: Plasma concentrations of apolipoproteins A-I, B and M in patients with abdominal aortic aneurysms.
abstract: OBJECTIVE
  Apolipoproteins play important roles in the development of atherosclerosis but their involvement in the pathogenesis of abdominal aortic aneurysm (AAA) is poorly understood. The aim was to investigate whether apoA-I, apoB and apoM are independently associated with AAA.
  
  
  METHODS
  Plasma apoA-I, apoB and apoM were measured in 343 patients with AAA and in 214 elderly apparently healthy control individuals from the background population.
  
  
  RESULTS
  AAA patients had lower apolipoprotein levels, as compared to healthy individuals: apoA-I, 1.62 vs. 2.08 g/L; apoB, 0.91 vs. 1.04 g/L; apoM, 0.72 vs. 0.91 mumol/L (p<0.0001 for all three). In multivariate analyses, apoA-I and apoB were associated with AAA, odds ratios (95% confidence intervals) being 0.53 (0.43-0.64) and 0.86 (0.75-0.998), respectively.
  
  
  CONCLUSIONS
  ApoA-I, apoB and apoM levels were significantly lower in patients with AAA than in the control individuals, but only apoA-I and apoB were independently associated to AAA.
authors.affiliation: Wallenberg Laboratory, Department of Laboratory Medicine, Clinical Chemistry, Lund University, SE-205 02 Malmö, Sweden.
authors.forename: Josefin
authors.initials: J
authors.lastname: Ahnström
authors.forename: Anders
authors.initials: A
authors.lastname: Gottsäter
authors.forename: Bengt
authors.initials: B
authors.lastname: Lindblad
authors.forename: Björn
authors.initials: B
authors.lastname: Dahlbäck
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000097:blood* / Q000188:drug therapy; D016632:Apolipoprotein A-I / Q000097:blood*; D001053:Apolipoproteins / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D000075243:Apolipoproteins M; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D054834:Lipocalins; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis
chemical_list: C400523:APOM protein, human; D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D001055:Apolipoproteins B; D000075243:Apolipoproteins M; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D054834:Lipocalins