Prognostic value of the t(14;18)(q32;q21) in patients with diffuse large B-cell lymphoma.
The prognostic significance of the t(14;18) in diffuse large B-cell lymphoma is still controversial. To assess the impact of the t(14;18) on patient survival, we investigated 26 patients with diffuse large B-cell lymphoma for the presence of t(14;18). The t(14;18) was detected in 90.9% of patients with high international prognostic index score. The five-year overall survival was 0.0% and 68.75% in positive and negative cases of t(14;18) respectively. The detection of the t(14;18) combined with the international prognostic index score is a useful strategy for more appropriate risk stratification and prediction of outcome of patients with diffuse large B-cell lymphoma.
Abdel-Ghaffar
Hasan
H
Mansoura University, Mansoura, Egypt.
El-Aziz
Sherin Abd
SA
Shahin
Doaa
D
Degheidy
Heba
H
Selim
Tarek
T
Elsobky
Ezzat
E
Attwan
Nadia
N
Al-Tonbary
Youssef A
YA
D000328:Adult; D000368:Aged; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D014178:Translocation, Genetic
D019253:Proto-Oncogene Proteins c-bcl-2