Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid.
The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS). Treatment was associated with low toxicity, but the KS clinical response and KS herpesvirus lytic induction rates were not sufficiently high to meet predefined criteria for efficacy.
Lechowicz
Maryjo
M
Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
Dittmer
Dirk P
DP
Lee
Jeannette Y
JY
Krown
Susan E
SE
Wachsman
William
W
Aboulafia
David
D
Dezube
Bruce J
BJ
Ratner
Lee
L
Said
Jonathan
J
Ambinder
Richard F
RF
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D005260:Female; D019288:Herpesvirus 8, Human / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis; D012514:Sarcoma, Kaposi / Q000188:drug therapy*; D014635:Valproic Acid / Q000627:therapeutic use*
D012367:RNA, Viral; D014635:Valproic Acid