CSF biomarkers: pinpointing Alzheimer pathogenesis.
Intense research during the last decades has resulted in an unprecedented accumulation of knowledge regarding the pathogenesis of Alzheimer's disease. Primarily, the focus has been directed toward amyloid and tau pathology and their relations to synaptic and neuronal loss. However, as the complexity of the disease becomes increasingly evident, the importance of other factors, such as inflammation, oxidative stress, and mitochondrial dysfunction, grow apparent. Here, we review available CSF biomarkers for these pathological processes. We also consider their usability in clinical practice and in clinical trials.
Mattsson
Niklas
N
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, S-431 80 Mölndal, Sweden.
Blennow
Kaj
K
Zetterberg
Henrik
H
D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000209:etiology / Q000473:pathology; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D002986:Clinical Trials as Topic; D006801:Humans; D007249:Inflammation / Q000473:pathology; D013569:Synapses / Q000473:pathology
D015415:Biomarkers