Deprotonation of the Asp1-Ala2 peptide bond induces modification of the dynamic copper(II) environment in the amyloid-beta peptide near physiological pH.
Hureau
Christelle
C
CNRS; LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, 31077 Toulouse, France. christelle.hureau@lcc-toulouse.fr
Coppel
Yannick
Y
Dorlet
Pierre
P
Solari
Pier Lorenzo
PL
Sayen
Stéphanie
S
Guillon
Emmanuel
E
Sabater
Laurent
L
Faller
Peter
P
D000409:Alanine; D000544:Alzheimer Disease; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D001224:Aspartic Acid; D001665:Binding Sites; D003300:Copper / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy
D016229:Amyloid beta-Peptides; D004151:Dipeptides; D001224:Aspartic Acid; D003300:Copper; D000409:Alanine