title: [Synthesis of cationic lipid transfection agents with O,O- or N,O-acetal bonds].
abstract: The synthesis of cationic lipids on the basis of 1,2-di-O-tetradecylglycerol is described. The cationic groups represented by the residues of nitrogen-containing heterocyclic bases are attached to the diglyceride backbone through O,O- and N,O-acetal bonds. The resulting lipids can be used as nonviral gene delivery systems to eukaryotic cells.
authors.affiliation: Lomonosov State Academy of Fine Chemical Technology, Moscow, Russia. mamaslov@mail.ru
authors.forename: M A
authors.initials: MA
authors.lastname: Maslov
authors.forename: N G
authors.initials: NG
authors.lastname: Morozova
authors.forename: I M
authors.initials: IM
authors.lastname: Senan
authors.forename: G A
authors.initials: GA
authors.lastname: Serebrennikova
mesh_terms: D002412:Cations; D004075:Diglycerides / Q000138:chemical synthesis* / Q000737:chemistry*; D014162:Transfection
chemical_list: D002412:Cations; D004075:Diglycerides; C057475:1,2-ditetradecylglycerol