Neurokinin 1 receptor gene polymorphism might be correlated with recurrence rates in endometriosis.
BACKGROUND
Dysmenorrhoea is the major symptom in women with endometriosis. Recently, pain modulation through Neurokinin-1-receptor (NK1R) pathways have been investigated in neuropathic pain patients. Aim of this study was, therefore, to examine the effect of a single nucleotide polymorphism (SNP) of the NK1R gene on the susceptibility for endometriosis and the disease free survival (DFS) after surgery for endometriosis.


METHODS
A case-control study was conducted and germline DNA was isolated. Patients were followed up for a recurrence of the disease up to 4 years. Case-control analyses were performed for parameters of the medical history and the genotype of the NK1R-SNP rs881. Furthermore, DFS probabilities were calculated.


RESULTS
Concerning the DFS preoperative pain levels and the NK1R genotype were independent predictors for a recurrence with hazard ratios of 2.55 (95% CI: 1.32-4.95) for patients with a high preoperative pain level and 0.44 for patients with a heterozygous or homozygous variant genotype in rs881 (95% CI: 0.21-0.88).


CONCLUSIONS
The polymorphism rs811 seems to be associated with a lower recurrence risk in endometriosis patients. Thus, there might be a clinical relevant role of the NK1 pathway in the pain perception of endometriosis patients.
Renner
Stefan P
SP
Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany.
Ekici
Arif B
AB
Maihöfner
Christian
C
Oppelt
Peter
P
Thiel
Falk C
FC
Schrauder
Michael
M
Uenluehan
Nesrin
N
Bani
Mayada R
MR
Strissel
Pamela L
PL
Strick
Reiner
R
Beckmann
Matthias W
MW
Fasching
Peter A
PA
D000328:Adult; D016022:Case-Control Studies; D018572:Disease-Free Survival; D004715:Endometriosis / Q000235:genetics* / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D010146:Pain / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide; D057234:Preoperative Period; D016016:Proportional Hazards Models; D018040:Receptors, Neurokinin-1 / Q000235:genetics*; D055502:Secondary Prevention
D018040:Receptors, Neurokinin-1