Enzymatic synthesis of a drug delivery system based on polyhydroxyalkanoate-protein block copolymers.
A new approach to prepare functional polymeric micelles in a one step reaction using the unique catalytic property of PHA synthase is described. A biopolymer-based nanocarrier with cancer targeting capability was successfully synthesized from genetically engineered PHA synthase fused with RGD peptide.
Kim
Han-Nah
HN
Institute of Life Sciences and Resources & Department of Food Science and Biotechnology, Kyung Hee University, Yongin 446-701, Korea.
Lee
Jin
J
Kim
Hae-Yeong
HY
Kim
Young-Rok
YR
D000217:Acyltransferases / Q000378:metabolism*; D004337:Drug Carriers / Q000138:chemical synthesis*; D016503:Drug Delivery Systems / Q000379:methods; D008823:Micelles; D009842:Oligopeptides / Q000737:chemistry*; D054813:Polyhydroxyalkanoates / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D011506:Proteins / Q000737:chemistry
D004337:Drug Carriers; D008823:Micelles; D009842:Oligopeptides; D054813:Polyhydroxyalkanoates; D011108:Polymers; D011506:Proteins; C047981:arginyl-glycyl-aspartic acid; D000217:Acyltransferases; C077225:poly(3-hydroxyalkanoic acid) synthase