title: Effects of aging on the human motor cortical plasticity studied by paired associative stimulation.
abstract: OBJECTIVE
  To test whether the normal aging itself may change the cortical plasticity in human.
  
  
  METHODS
  Motor-evoked potentials (MEPs) were measured from 48 right-handed healthy volunteers (age 21-79) before and after the paired associative stimulation (PAS), comprising a single electric stimulus to the right median nerve at wrist and subsequent transcranial magnetic stimulation (TMS) of the left primary motor cortex.
  
  
  RESULTS
  The magnitude of MEP increased by PAS in the young and middle but not in the elderly and its change was negatively correlated with the age.
  
  
  CONCLUSIONS
  These results suggest that the human M1 shows age-dependent reduction of cortical plasticity.
  
  
  CONCLUSIONS
  The reduction of the M1 plasticity may be caused by the attenuated responsiveness of intracortical circuits in the M1 and/or disrupted sensorimotor integration within basal ganglia-thalamocortical loop.
authors.affiliation: Human Brain Research Center, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Dina
authors.initials: D
authors.lastname: Fathi
authors.forename: Yoshino
authors.initials: Y
authors.lastname: Ueki
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Mima
authors.forename: Satoko
authors.initials: S
authors.lastname: Koganemaru
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagamine
authors.forename: Amal
authors.initials: A
authors.lastname: Tawfik
authors.forename: Hidenao
authors.initials: H
authors.lastname: Fukuyama
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001479:Basal Ganglia / Q000502:physiology; D004558:Electric Stimulation; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology*; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D013788:Thalamus / Q000502:physiology; D050781:Transcranial Magnetic Stimulation