Pentagalloylglucose down-regulates mast cell surface FcepsilonRI expression in vitro and in vivo.
Mast cell activation by immunoglobulin E (IgE)-mediated stimuli is a central event in the pathogenesis of allergic disorders. The present report shows that treatment with pentagalloylglucose (PGG) resulted in a down-regulation of FcepsilonRI surface expression on mucosal-type murine bone marrow-derived mast cells (mBMMCs), which correlated with a reduction in IgE-mediated activation of mBMMCs. Furthermore, PGG prevented development of allergic diarrhea in a food-allergy mouse model and suppressed the up-regulated FcepsilonRI surface expression on mast cells derived from the food-allergy mouse colon. These findings on PGG suggest its therapeutic potential for allergic diseases through suppressing the FcepsilonRI surface expression.
Kageyama-Yahara
Natsuko
N
Division of Gastrointestinal Pathophysiology, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan. natsuko@inm.u-toyama.ac.jp
Suehiro
Yoko
Y
Maeda
Futoshi
F
Kageyama
Shun-ichiro
S
Fukuoka
Junya
J
Katagiri
Tatsuo
T
Yamamoto
Takeshi
T
Kadowaki
Makoto
M
D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects / Q000276:immunology; D002478:Cells, Cultured; D003967:Diarrhea / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D015536:Down-Regulation; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005512:Food Hypersensitivity / Q000276:immunology* / Q000473:pathology; D047348:Hydrolyzable Tannins / Q000494:pharmacology*; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D029596:Paeonia / Q000737:chemistry; D017455:Receptors, IgE / Q000037:antagonists & inhibitors* / Q000276:immunology
D004365:Drugs, Chinese Herbal; D047348:Hydrolyzable Tannins; D017455:Receptors, IgE; C090831:kakkon-to; D007073:Immunoglobulin E; C435084:pentagalloylglucose