Fabrication and biocompatibility investigation of TiO(2) films on the polymer substrates obtained via a novel and versatile route.
Titanium oxide (TiO(2)) films were successfully deposited onto the polymer substrates of polytetrafluoroethylene (PTFE), polyethylene (PE), and polyethylene terephthalate (PET), which were pre-modified with polydopamine coating (polydopamine and its coating are coded as PDA and PDAc, respectively), by a simple liquid phase deposition (LPD) process. The morphology and chemical state of the obtained TiO(2) films were characterized by field emission scanning electron microscope (FE-SEM) and X-ray photoelectron spectroscopy (XPS), respectively. Subsequently, the biocompatibility of the samples was investigated by 3-(4,5-dimethyldiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) colorimetric assay and acridine orange staining of MC-3T3 osteoblast cells, and the results demonstrated that the fabricated TiO(2) films could markedly improve the in vitro cytocompatibility. So, the presented route is anticipated to be a promising surface modification methodology to improve the practical outcome of the implanted materials for its versatility and validity.
Ou
Junfei
J
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China.
Wang
Jinqing
J
Zhang
Dong
D
Zhang
Puliang
P
Liu
Sheng
S
Yan
Penghua
P
Liu
Bin
B
Yang
Shengrong
S
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D020959:Polyethylene / Q000737:chemistry* / Q000494:pharmacology; D011093:Polyethylene Terephthalates / Q000737:chemistry* / Q000494:pharmacology; D011138:Polytetrafluoroethylene / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
D011093:Polyethylene Terephthalates; C009495:titanium dioxide; D011138:Polytetrafluoroethylene; D020959:Polyethylene; D014025:Titanium