[Flumazenil restores amnesic trace of memory in mice with depression-like state].
Experiments on C57BL/6J mice of submissive stereotype and behavioral despair response and ASC/Icg mice with high predisposition to catalepsy, which served as depression-like state models, were used to study the influence of benzodiazepine receptor antagonist flumazenil on the restoration of a passive avoidance reaction learned under conditions of the amnesic effect of animal detention in a dark compartment. It is established, that flumazenil (10 mg/kg) reactivated retrieval of the amnesic memory trace in mice of submissive stereotype with the behavioral despair response, while being ineffective in ASC mice.
Dubrovina
N I
NI
Zinov'eva
D V
DV
D000647:Amnesia / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005442:Flumazenil / Q000494:pharmacology*; D018757:GABA Modulators / Q000494:pharmacology*; D058787:GABA-A Receptor Antagonists; D051379:Mice; D011963:Receptors, GABA-A / Q000378:metabolism; D013045:Species Specificity
D018757:GABA Modulators; D058787:GABA-A Receptor Antagonists; D011963:Receptors, GABA-A; D005442:Flumazenil