title: Systemic analysis of the symbiotic function of Buchnera aphidicola, the primary endosymbiont of the pea aphid Acyrthosiphon pisum.
abstract: Buchnera aphidicola is the primary obligate intracellular symbiont of most aphid species. B. aphidicola and aphids have been evolving in parallel since their association started, about 150 Myr ago. Both partners have lost their autonomy, and aphid diversification has been confined to smaller ecological niches by this co-evolution. B. aphidicola has undergone major genomic and biochemical changes as a result of adapting to intracellular life. Several genomes of B. aphidicola from different aphid species have been sequenced in the last decade, making it possible to carry out analyses and comparative studies using system-level in silico methods. This review attempts to provide a systemic description of the symbiotic function of aphid endosymbionts, particularly of B. aphidicola from the pea aphid Acyrthosiphon pisum, by analyzing their structural genomic properties, as well as their genetic and metabolic networks.
authors.affiliation: UMR203 BF2I, Biologie fonctionnelle insectes et interactions, Université de Lyon, INRA, INSA-Lyon, IFR41, 20, avenue A. Einstein, 69621 Villeurbanne, France.
authors.forename: Lilia
authors.initials: L
authors.lastname: Brinza
authors.forename: José
authors.initials: J
authors.lastname: Viñuelas
authors.forename: Ludovic
authors.initials: L
authors.lastname: Cottret
authors.forename: Federica
authors.initials: F
authors.lastname: Calevro
authors.forename: Yvan
authors.initials: Y
authors.lastname: Rahbé
authors.forename: Gérard
authors.initials: G
authors.lastname: Febvay
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Duport
authors.forename: Stefano
authors.initials: S
authors.lastname: Colella
authors.forename: Andréane
authors.initials: A
authors.lastname: Rabatel
authors.forename: Christian
authors.initials: C
authors.lastname: Gautier
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Fayard
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Sagot
authors.forename: Hubert
authors.initials: H
authors.lastname: Charles
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001042:Aphids / Q000166:cytology / Q000382:microbiology* / Q000502:physiology; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology; D020635:Buchnera / Q000145:classification / Q000235:genetics / Q000502:physiology*; D002876:Chromosomes, Bacterial / Q000235:genetics; D019143:Evolution, Molecular; D015964:Gene Expression Regulation, Bacterial; D053263:Gene Regulatory Networks; D005798:Genes, Bacterial; D040961:Genetic Drift; D016680:Genome, Bacterial; D023281:Genomics; D053858:Metabolic Networks and Pathways / Q000235:genetics; D018532:Pisum sativum / Q000469:parasitology*; D010802:Phylogeny; D013559:Symbiosis / Q000235:genetics / Q000502:physiology*
chemical_list: D000596:Amino Acids; D001426:Bacterial Proteins