Chronic hepatitis with eosinophilic infiltration associated with asthma.
A 49-year-old asthmatic woman with a history of drug allergy to aspirin and penicillin presented to the hospital with fever, dark urine, general exanthema and fatigue. Physical examination revealed jaundice. She had been taking four different over-the-counter drugs. Laboratory examination showed eosinophilia, elevated Ig E, hyperbilirubinemia and elevated liver function tests. HBs Ag, anti-HCV Ab and Ig M anti-HA were negative. She was initially diagnosed with drug-induced hepatitis and was treated with steroids. However, liver dysfunction with eosinophilia relapsed after discontinuing steroids. Liver biopsy revealed eosinophilic infiltration. Steroids were discontinued after the start of 6-mercaptopurine.
Omata
Fumio
F
Gastroenterology Center, St Luke's International Hospital, Tokyo. f_omata@mac.com
Shibata
Minoru
M
Nakano
Masayuki
M
Jacobs
Joshua L
JL
Tokuda
Yasuharu
Y
Yasuharu
Tokuda
T
Fukutake
Katsuhide
K
Takahashi
Osamu
O
Fukui
Tsuguya
T
D001249:Asthma / Q000150:complications*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000150:complications; D004802:Eosinophilia / Q000150:complications*; D005260:Female; D019693:Hepatitis, Autoimmune / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology*; D008111:Liver Function Tests; D008875:Middle Aged