title: Spontaneously formed unilamellar vesicles.
abstract: Mixtures of long- and short-chain phospholipids can spontaneously form uniform unilamellar vesicles (ULVs) with diameters 50 nm (polydispersities of <0.3) or less. The morphology of these ULVs has mainly been characterized using small angle neutron scattering (SANS), a technique highly suited for the study of hydrogenous materials. Once formed, these ULVs have turned out to be highly stable and show great promise as imaging and therapeutic carriers.
authors.affiliation: Canadian Neutron Beam Centre, Steacie Institute for Molecular Sciences, Chalk River Laboratories, National Research Council Canada, Chalk River, Ontario, Canada.
authors.forename: Mu-Ping
authors.initials: MP
authors.lastname: Nieh
authors.forename: Norbert
authors.initials: N
authors.lastname: Kucerka
authors.forename: John
authors.initials: J
authors.lastname: Katsaras
mesh_terms: D008055:Lipids / Q000737:chemistry; D008081:Liposomes; D008823:Micelles
chemical_list: D008055:Lipids; D008081:Liposomes; D008823:Micelles