Atypical acute leukemia early after liver transplantation.
Acute myeloid leukemia (AML) has been rarely reported after transplantation, namely seven cases described so far. The putative mechanism of action is long-standing immunosuppression, even though no clear correlation with the type of drug has ever been demonstrated. We report the case of a 28-year-old male patient who presented with a early onset of AML after liver transplantation for hepatitis B virus-related acute liver failure. The AML was characterized by aggressive clinical features with extrahematologic sites of involvement and an atypical immunophenotype; the laboratory findings were consistent with the diagnosis of monocytic acute leukemia.
Mannelli
F
F
Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy.
De Simone
P
P
Gianfaldoni
G
G
Nozzoli
C
C
Filipponi
F
F
Bosi
A
A
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001853:Bone Marrow / Q000473:pathology; D006680:HLA Antigens / Q000235:genetics; D006509:Hepatitis B / Q000601:surgery; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D017093:Liver Failure / Q000601:surgery* / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D016896:Treatment Outcome; D014682:Vena Cava, Inferior / Q000473:pathology
D006680:HLA Antigens