title: Molecular detection of novel adenoviruses in fecal specimens of captive monkeys with diarrhea in China.
abstract: Adenovirus (AdV) has been recently detected among monkeys with diarrhea in a major research primate colony in China. To better assess disease burden and epidemiology of adenoviruses in the colony, we examined the prevalence of this virus in fecal specimens by PCR using broadly reactive hexon gene-specific primers. Of the 29 strains that were characterized by sequence and phylogenetic analysis, we identified a broad spectrum of simian AdV (SAdV) types, including species SAdV-A (n=14) and HAdV-G (n=9). Six additional strains represented two genetic clusters distantly related to other known SAdVs. A better understanding of the epidemiology of SAdVs and their potential role in gastroenteritis is critical to the implementation of advanced prevention strategies against AdV infection in captive primates.
authors.affiliation: Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
authors.forename: K
authors.initials: K
authors.lastname: Bányai
authors.forename: M D
authors.initials: MD
authors.lastname: Esona
authors.forename: A
authors.initials: A
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Tu
authors.forename: B
authors.initials: B
authors.lastname: Jiang
mesh_terms: D000257:Adenoviridae Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D000261:Adenoviruses, Simian / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D000818:Animals; D036022:Capsid Proteins / Q000235:genetics; D002681:China / Q000453:epidemiology; D003967:Diarrhea / Q000821:virology*; D005243:Feces / Q000821:virology; D000882:Haplorhini; D008992:Monkey Diseases / Q000453:epidemiology / Q000821:virology*; D010802:Phylogeny; D016133:Polymerase Chain Reaction
chemical_list: D036022:Capsid Proteins; C018315:hexon capsid protein, Adenovirus