title: Mediastinal gastroenteric cyst in a neonate containing respiratory-type epithelium and pancreatic tissue.
abstract: Mediastinal gastroenteric cyst is an uncommon congenital malformation and a distinct histopathological entity within the family of foregut duplication cysts. This lesion is mainly encountered in neonates and infants. Histologically, it is characterized by double-layered smooth muscle wall and gastric lining mucosa. We report on a case of a 2-day-old girl, with a posterior mediastinal cystic mass associated with T3-T4 hemivertebrae, presenting with severe respiratory distress. The cyst was multilocular, surgically removed, and histopathologic analysis revealed that it was of gastroenteric type. However, in numerous areas of the lesion, respiratory-type epithelium was observed, as well as pancreatic tissue. After removal of the lesion the patient made an uneventful recovery and shows no signs of long-term pulmonary sequelae. We failed to demonstrate in the available literature the presence of this variable epithelial lining within a single mediastinal foregut cyst. In addition, pancreatic tissue within an intrathoracic enteric cyst has been reported only twice.
authors.affiliation: Department of Pathology, Hippokration General Hospital of Thessaloniki, Thessaloniki, Greece. eleanagn@otenet.gr
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Anagnostou
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Soubasi
authors.forename: Eleni
authors.initials: E
authors.lastname: Agakidou
authors.forename: Christos
authors.initials: C
authors.lastname: Papakonstantinou
authors.forename: Polychronis
authors.initials: P
authors.lastname: Antonitsis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Antonitsis
authors.forename: Maria
authors.initials: M
authors.lastname: Leontsini
mesh_terms: D002828:Choristoma; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008476:Mediastinal Cyst / Q000473:pathology*; D010179:Pancreas; D020545:Respiratory Mucosa