title: Effect of treatment by nasal continuous positive airway pressure on serum high mobility group box-1 protein in obstructive sleep apnea.
abstract: BACKGROUND
  Serum levels of high mobility group box-1 protein (HMGB1) are increased in a variety of inflammatory disorders. Obstructive sleep apnea syndrome (OSAS) is associated with inflammation secondary to chronic intermittent hypoxia, but HMGB1 levels in treated and untreated OSAS have not been evaluated.
  
  
  METHODS
  Twenty healthy subjects and 30 subjects with moderately severe or severe OSAS who desired nasal continuous positive airway pressure (CPAP) treatment were enrolled. Serum levels of HMGB1 and nitric oxide derivative (NO(x)) from peripheral blood samples were measured, and all subjects underwent a sleep study. These studies were repeated 2 months after nasal CPAP treatment in the patients with OSAS.
  
  
  RESULTS
  In OSAS before nasal CPAP treatment, the serum level of HMGB1 was higher but that of NO(x) was lower than those levels of normal subjects. The HMGB1 levels correlated negatively with NO(x) levels in subjects with OSAS. After nasal CPAP treatment, the HMGB1 and NO(x) returned to normal levels.
  
  
  CONCLUSIONS
  Elevated HMGB1 levels and reduced NO(x) levels in patients with OSAS normalized after nasal CPAP treatment.
authors.affiliation: Chest Division, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
authors.forename: Kun-Ming
authors.initials: KM
authors.lastname: Wu
authors.forename: Ching-Chi
authors.initials: CC
authors.lastname: Lin
authors.forename: Chung-Hsin
authors.initials: CH
authors.lastname: Chiu
authors.forename: Shwu-Fang
authors.initials: SF
authors.lastname: Liaw
mesh_terms: D015415:Biomarkers / Q000097:blood; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D024243:HMGB1 Protein; D009569:Nitric Oxide