title: Possible roles of IL-27 in the pathogenesis of psoriasis.
abstract: The immunological significance of IL-27 has been reported and discussed in various Th1/Th17-mediated inflammatory diseases. However, its importance in psoriasis is unknown. We investigated pathophysiological roles of IL-27 in psoriasis in this study. Serum IL-27 levels in psoriatic patients were significantly higher than those in healthy controls, and correlated with disease severity and serum IFN-gamma levels. An immunohistochemical analysis revealed the infiltration of IL-27-secreting cells in the papillary dermis of psoriatic skin lesions but not in skin lesions with atopic dermatitis or normal skin. Furthermore, IL-27 alone greatly induced in vitro CXCL9, CXCL10, and CXCL11 production and tyrosine phosphorylation of signal transducer and activator of transcription 1 in normal human keratinocytes, while it suppressed the tumor necrosis factor-alpha-induced production of IL-1alpha and CCL20. These results indicate that IL-27 may promote the onset of psoriasis, while it may simultaneously attenuate the expanded inflammation in this disease. Our results implicate potential therapeutic effects of IL-27 for psoriasis.
authors.affiliation: Faculty of Medicine, Department of Dermatology, University of Tokyo, Tokyo, Japan. sayakashibata-tky@umin.ac.jp
authors.forename: Sayaka
authors.initials: S
authors.lastname: Shibata
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Tada
authors.forename: Naoko
authors.initials: N
authors.lastname: Kanda
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Nashiro
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kamata
authors.forename: Masaru
authors.initials: M
authors.lastname: Karakawa
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Miyagaki
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Kai
authors.forename: Hidehisa
authors.initials: H
authors.lastname: Saeki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shirakata
authors.forename: Shinichi
authors.initials: S
authors.lastname: Watanabe
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Tamaki
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D054418:Chemokine CCL20 / Q000378:metabolism; D054357:Chemokine CXCL10 / Q000378:metabolism; D054371:Chemokine CXCL11 / Q000378:metabolism; D054370:Chemokine CXCL9 / Q000378:metabolism; D020405:Dermis / Q000276:immunology / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007371:Interferon-gamma / Q000097:blood; D053582:Interleukin-1alpha / Q000378:metabolism; D007378:Interleukins / Q000097:blood* / Q000276:immunology*; D015603:Keratinocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation / Q000276:immunology; D011565:Psoriasis / Q000209:etiology / Q000276:immunology / Q000503:physiopathology; D012720:Severity of Illness Index; D015398:Signal Transduction / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D015854:Up-Regulation / Q000276:immunology
chemical_list: C108355:CCL20 protein, human; C114753:CXCL10 protein, human; C515202:CXCL11 protein, human; C080810:CXCL9 protein, human; D054418:Chemokine CCL20; D054357:Chemokine CXCL10; D054371:Chemokine CXCL11; D054370:Chemokine CXCL9; D053582:Interleukin-1alpha; D007378:Interleukins; C464565:MYDGF protein, human; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma