title: Study of human metapneumovirus-associated lower respiratory tract infections in Egyptian adults.
abstract: There is a deficiency in the data concerning the role of hMPV in lower respiratory tract infections in adults, and until now there has been no data available regarding the prevalence of hMPV in adults in our region. In the present study the association of hMPV with varieties of lower respiratory tract disorders in immunocompetent adult patients, either alone or with bacterial pathogens, has been highlighted. Eighty-eight patients were included in the study. They included 46 males and 42 females with an age range of 38-65 years. Patients presented with lower respiratory tract infections associated with acute exacerbation of asthma (67%), pneumonia (17%), and acute exacerbation of chronic obstructive lung diseases. Sputum and nasopharyngeal samples were obtained from the patients and subjected to a full microbiological study. In addition, detection of hMPV was performed by nested reverse transcriptase polymerase chain reaction. The pathogens isolated were Streptococcus pneumoniae 46.6%, Staphylococci aureus 35.2%, and human metapneumovirus 13.6%. Influenza virus and rhinovirus were each isolated from 4.5% of patients. Human metapneumovirus was associated with S. pneumoniae in 4.5% in studied patients, while in 9.1% it was the only pathogen found in those patients. The commonest clinical condition with significant association with human metapneumovirus was pneumonia. The clinical and laboratory studies demonstrated an association between lower respiratory tract infections in adults and hMPV either as sole pathogen or in association with Streptococcus pneumoniae. It was a common pathogen in community-acquired pneumonia.
authors.affiliation: Department of Clinical Pathology, Faculty of Medicine, Mansoura University, El Gomhoria Street 60, 35516 Mansoura, Egypt. may_s65@hotmail.com
authors.forename: Maysaa
authors.initials: M
authors.lastname: El Sayed Zaki
authors.forename: Douaa
authors.initials: D
authors.lastname: Raafat
authors.forename: Amal Abd
authors.initials: AA
authors.lastname: El-Metaal
authors.forename: Mona
authors.initials: M
authors.lastname: Ismail
mesh_terms: D000328:Adult; D004534:Egypt; D005260:Female; D006801:Humans; D008297:Male; D029121:Metapneumovirus; D008875:Middle Aged; D018184:Paramyxoviridae Infections / Q000150:complications / Q000503:physiopathology / Q000821:virology*; D011018:Pneumonia, Pneumococcal / Q000150:complications / Q000382:microbiology / Q000503:physiopathology / Q000821:virology; D011024:Pneumonia, Viral / Q000150:complications / Q000503:physiopathology / Q000821:virology; D012141:Respiratory Tract Infections / Q000503:physiopathology / Q000821:virology*; D013296:Streptococcus pneumoniae / Q000302:isolation & purification