The influence of odorants on respiratory patterns in sleep.
To assess the feasibility of using odors as a potential mechanism for treating sleep apnea, we set out to test the hypothesis that odorants delivered during sleep would modify respiratory patterns without inducing arousal or wake in healthy sleepers. We used 2 mildly trigeminal odorants: the pleasant lavender and unpleasant vetiver oil and 2 pure olfactory odorants: the pleasant vanillin and unpleasant ammonium sulfide. During sleep, an olfactometer delivered a transient odorant every 9, 12, or 15 min (randomized), providing 21-37 odorant presentations per night. Each of 36 participants was studied for 1 night and with 1 of the 4 different odorants tested. In addition to standard overnight polysomnography, we employed highly accurate measurements of nasal and oral respiration. Odorants did not increase the frequency of arousals or wake but did influence respiration. Specifically, all 4 odorants transiently decreased inhalation and increased exhalation for up to 6 breaths following odor onset. This effect persisted regardless of odorant valence or stage of sleep. These results suggest that the olfactory system may provide a path to manipulate respiration in sleep.
Arzi
Anat
A
Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel. anat.arzi@weizmann.ac.il
Sela
Lee
L
Green
Amit
A
Givaty
Gili
G
Dagan
Yaron
Y
Sobel
Noam
N
D000328:Adult; D001143:Arousal / Q000502:physiology; D001547:Benzaldehydes / Q000494:pharmacology; D005260:Female; D006801:Humans; D027523:Lavandula; D008297:Male; D009812:Odorants; D009822:Oils, Volatile / Q000494:pharmacology; D010938:Plant Oils / Q000494:pharmacology; D017286:Polysomnography; D012119:Respiration / Q000187:drug effects*; D012890:Sleep; D013440:Sulfides / Q000494:pharmacology
D001547:Benzaldehydes; D009822:Oils, Volatile; D010938:Plant Oils; D013440:Sulfides; C027711:ammonium sulfide; C100058:vanillin; C045718:lavender oil