Current concepts on hyperpolarized molecules in MRI.
Hyperpolarization provides a strong enhancement of the MR signal and allows the acquisition of images from nuclei other than protons. Besides vascular imaging and perfusion studies the use of hyperpolarized molecules has allowed the visualization of real-time substrate uptake and metabolism in vivo. Metabolic imaging is an outstanding field of research that aims at providing the clinicians with the possibility of interrogating real-time complex metabolic pathways that give a direct insight into the cellular state and activity.
Viale
Alessandra
A
Department of Chemistry, IFM and Molecular Imaging Centre, University of Torino, V. Nizza 52, 10126 Torino, Italy. alessandra.viale@unito.it
Aime
Silvio
S
D000818:Animals; D002247:Carbon Isotopes / Q000737:chemistry / Q000378:metabolism; D003287:Contrast Media / Q000737:chemistry* / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D057054:Molecular Imaging
D002247:Carbon Isotopes; D003287:Contrast Media