title: A cross-sectional study for the analysis of clinical, sexual and laboratory conditions associated to Peyronie's disease.
abstract: BACKGROUND
  Although Peyronie's Disease (PD) was first described over 250 years ago, its precise etiology remains obscure.
  
  
  OBJECTIVE
  Analyze a variety of potential associated factors with PD, including erectile dysfunction.
  
  
  METHODS
  This cross-sectional study included 83 consecutive men with PD and 252 age-matched controls. All men completed the International Index of Erectile Function (IIEF) and were evaluated regarding their clinical and demographic characteristics, comorbidities, and used medications. Anthropometric measures included body mass index and waist circumference (WC). Fasting blood glucose, lipid profile, total testosterone, and dehydroepiandrosterone-sulfate were determined.
  
  
  METHODS
  Clinical and laboratory characteristics associated to PD.
  
  
  RESULTS
  The mean age was 59.2 + or - 10 years in the cases and 59.7 + or - 12 years in the controls. Marital status, current smoking, and excessive consumption of alcoholic beverages were similar between groups (P > 0.05). PD was more common among white skin color males (P = 0.001). The mean score for each IIEF domain and the androgen levels were similar in the two groups. Thiazides were the only medication associated to PD (P = 0.03). Dupuytren's disease was more frequent among individuals with PD (P = 0.001). The distribution of all other comorbidities investigated was similar between groups (P > 0.05). The characteristics WC > 102 cm and levels of low-density lipoprotein (LDL) > 130 mg/dL were more prevalent in the controls (P < 0.05). After multivariate analysis, white skin color (OR: 8.47, 95%CI: 1.98-36.24) and thiazide use (OR: 2.29, 95%CI: 1.07-4.90) were associated to PD, and LDL > 130 mg/dL (OR: 0.55, 95%CI: 0.32-0.92) and WC > 102 cm (OR: 0.53, 95%CI: 0.29-0.96) were inversely associated to PD.
  
  
  CONCLUSIONS
  In this study, PD was more common among white skin colored males. An inverse relationship with the presence of elevated serum levels of LDL and WC was observed. We found no association with medications other than thiazides and comorbidities other than Dupuytren's disease. Androgen serum levels and sexual dysfunction had also no association to PD.
authors.affiliation: Universidade Federal do Rio Grande do Sul (UFRGS)-Postgraduate Course in Medical Sciences, Porto Alegre, RS, Brazil. ernanirhoden@yahoo.com.br
authors.forename: Ernani Luis
authors.initials: EL
authors.lastname: Rhoden
authors.forename: Charles Edison
authors.initials: CE
authors.lastname: Riedner
authors.forename: Sandra C
authors.initials: SC
authors.lastname: Fuchs
authors.forename: Sandra
authors.initials: S
authors.lastname: Fuchs
authors.forename: Eduardo Porto
authors.initials: EP
authors.lastname: Ribeiro
authors.forename: Graziele
authors.initials: G
authors.lastname: Halmenschlager
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001938:Brazil; D016022:Case-Control Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D004387:Dupuytren Contracture / Q000175:diagnosis / Q000453:epidemiology; D007172:Erectile Dysfunction / Q000175:diagnosis* / Q000453:epidemiology* / Q000208:ethnology; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010411:Penile Induration / Q000175:diagnosis* / Q000453:epidemiology* / Q000208:ethnology; D012307:Risk Factors; D012725:Sexual Behavior; D012959:Socioeconomic Factors; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects; D013739:Testosterone / Q000097:blood; D055105:Waist Circumference; D044465:White People
chemical_list: D001786:Blood Glucose; D008055:Lipids; D049993:Sodium Chloride Symporter Inhibitors; D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate