title: Eccrine angiomatous hamartoma: a rare multifocal variant with features suggesting trauma.
abstract: Eccrine angiomatous hamartoma (EAH) is a rare, benign cutaneous tumor characterized by proliferation of the eccrine gland elements closely associated with capillary angiomatosis and proliferation of other dermal elements, such as adipose tissue, hair and epidermis. Patients usually present with a solitary nodule on the extremities appearing at birth or during the prepubertal years. However multifocal lesions or late onset of this condition may occur. Eccrine angiomatous hamartoma is usually sporadic, but one familial case of the multifocal variant has been reported. The clinical presentation ranges from a simple angiomatous nodule to erythematous--purpuric plaques. Eccrine angiomatous hamartoma is generally asymptomatic but may occasionally be associated with pain and hyperhidrosis. We report a rare case of the multifocal variant of EAH in a 13-year-old girl, with histological features suggesting trauma. Clinically, this condition must be differentiated from other angiomatoses and a definitive diagnosis is based upon histology. Eccrine angiomatous hamartoma is a benign slowly growing lesion for which aggressive treatment is not indicated. Simple excision is reserved for painful or cosmetically disfiguring examples.
authors.affiliation: Department of Cellular Pathology, Pathlinks Pathology Services, Lincoln County Hospital, Lincoln, United Kingdom.
authors.forename: Veena
authors.initials: V
authors.lastname: Naik
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Arsenovic
authors.forename: Malcolm
authors.initials: M
authors.lastname: Reed
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D004439:Eccrine Glands / Q000473:pathology*; D005260:Female; D017276:Friction; D006222:Hamartoma / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D006390:Hemangioendothelioma / Q000175:diagnosis; D006391:Hemangioma / Q000175:diagnosis; D006394:Hemangiosarcoma / Q000175:diagnosis; D006801:Humans; D008202:Lymphangioma / Q000175:diagnosis; D018329:Nevus, Blue / Q000175:diagnosis; D012867:Skin / Q000293:injuries; D012878:Skin Neoplasms / Q000175:diagnosis; D013543:Sweat Gland Diseases / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology