Roles of laminin-332 and alpha6beta4 integrin in tumor progression.
Laminin-332 and alpha6beta4 integrin is major hemidesmosome components in the skin. As many studies have shown that laminin-332 and alpha6beta4 integrin play important roles in tumor progression via activation of phosphatidylinositol-3 kinase signaling, understanding of the molecular mechanisms of them could lead to a new drug for cancer therapy.
Kariya
Y
Y
Tohoku Pharmaceutical University, Aoba-ku, Sendai, Miyagi, Japan. yoshi_kariya@yahoo.co.jp
Kariya
Y
Y
Gu
J
J
D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000378:metabolism / Q000502:physiology*; D002465:Cell Movement; D018450:Disease Progression; D005109:Extracellular Matrix / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D039161:Integrin alpha6beta4 / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction; D000097794:Kalinin
D015815:Cell Adhesion Molecules; D039161:Integrin alpha6beta4; D020794:Receptor Protein-Tyrosine Kinases; D000097794:Kalinin