title: Prosthetic joint infections: single versus combination therapy.
abstract: Prosthetic joint replacement is increasingly used to alleviate pain and increase mobility. Bone and joint infections remain a therapeutic dilemma for healthcare providers in all fields. Antimicrobial agents combined with appropriate surgical techniques play a vital role in eradicating infections associated with prosthetic joints. The question still remains whether monotherapy or combination therapy is effective in this situation because there is a paucity of well-defined comparative studies. We reviewed in vitro and in vivo studies evaluating the effectiveness of various antimicrobial agents either as single agents or in combination.
authors.affiliation: Department of Microbiology, Freeman Hospital, Newcastle upon Tyne, UK. julie.samuel@nuth.nhs.uk
authors.forename: J R
authors.initials: JR
authors.lastname: Samuel
authors.forename: F K
authors.initials: FK
authors.lastname: Gould
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D004347:Drug Interactions; D004359:Drug Therapy, Combination / Q000379:methods; D006801:Humans; D007592:Joint Diseases / Q000188:drug therapy* / Q000601:surgery; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents