TP53 Polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor.
The canine transmissible venereal tumor (CTVT) is found mainly in dogs' sexual organs. Currently, it is widely accepted that all samples of CTVT show similar histopathological characteristics and share common genetic alterations. Despite the common genetic origin of CTVT, mutations in the P53 gene have been reported. In this study, we proposed that tumor samples can be genetically grouped using this gene. The presence of different subgroups of CTVT was determined in Mexican dogs using the TP53 gene sequence in CTVT samples. Four new polymorphisms were found and therefore, the CTVT samples were classified in five subgroups.
Sánchez-Servín
Abel
A
Centro de Investigación y de Estudios Avanzados en Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Carretera de cuota Toluca-Atlacomulco, Kilómetro 15.5 C.P. 50200, Toluca Edo, México.
Martínez
Simón
S
Córdova-Alarcon
Emilio
E
Fajardo
Raúl
R
D000818:Animals; D001483:Base Sequence; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D008969:Molecular Sequence Data; D009154:Mutation; D011110:Polymorphism, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D014685:Venereal Tumors, Veterinary / Q000235:genetics*
D016159:Tumor Suppressor Protein p53