Neonatal alloimmune thrombocytopenia caused by anti-HLA-A24 alloantibodies.
Neonatal alloimmune thrombocytopenia (NAIT) occurs as a result of maternal alloimmunization against paternally inherited antigens on foetal platelets. Platelets express platelet specific antigens (HPA) along with human leucocyte antigens (HLA) class I. Although anti-HLA class I antibodies are often detectable in pregnant women, their role in NAIT is considered controversial. We report a case of NAIT where the most sensitive serological analysis and molecular methods could not detect platelet specific antibodies. Only HLA incompatibility and presence of anti-HLA-A24 antibodies in both the mother's and the newborn's serum were proven.


CONCLUSIONS
This case supports the idea that some anti-HLA class I antibodies could cause NAIT.
Starcevic
M
M
Department of Neonatology, University hospital Sestre milosrdnice, Zagreb, Croatia. mirta_ps@yahoo.com
Tomicic
M
M
Malenica
M
M
Zah-Matakovic
V
V
D001792:Blood Platelets / Q000276:immunology; D005260:Female; D015234:HLA-A Antigens / Q000276:immunology*; D059871:HLA-A24 Antigen; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D010976:Platelet Count; D011247:Pregnancy; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D055815:Young Adult
D015234:HLA-A Antigens; D059871:HLA-A24 Antigen; D007518:Isoantibodies