title: Does depression reduce the effectiveness of behavioral weight loss treatment?
abstract: Limited evidence suggests that depression is associated with poorer outcomes in behavioral weight loss programs; however, people with major depression are typically excluded from weight loss intervention trials. This study examined the effect of depression on women's participation and weight loss in behavioral treatment. Non-treatment seeking obese women over 40 years of age with major depressive disorder (MDD, n = 65) and without MDD (n = 125) were recruited into a 26-session group intervention. Primary analyses compared participants' mean weight change from baseline to 6 and 12 months; at 6 months, women with MDD lost a mean of 3.8 kg vs 4.3 kg for women without MDD (t = 0.54, p = .59). At 12 months, women with MDD lost 3.0 kg and women without MDD lost 3.6 kg (t = 0.44, p =.66). Women who attended at least 12 treatment sessions lost more weight than women who attended fewer sessions, regardless of depression status (ie, there was no significant interaction between depression and session attendance). Results suggest that depression should not be an exclusion criterion for weight loss intervention programs.
authors.affiliation: Group Health Research Institute, Group Health Cooperative, 1730 Minor Ave, Suite 1600, Seattle, WA 98101, USA. ludman.e@ghc.org
authors.forename: Evette
authors.initials: E
authors.lastname: Ludman
authors.forename: Gregory E
authors.initials: GE
authors.lastname: Simon
authors.forename: Laura E
authors.initials: LE
authors.lastname: Ichikawa
authors.forename: Belinda H
authors.initials: BH
authors.lastname: Operskalski
authors.forename: David
authors.initials: D
authors.lastname: Arterburn
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Linde
authors.forename: Robert W
authors.initials: RW
authors.lastname: Jeffery
authors.forename: Paul
authors.initials: P
authors.lastname: Rohde
authors.forename: Emily A
authors.initials: EA
authors.lastname: Finch
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D001521:Behavior Therapy; D003865:Major Depressive Disorder / Q000150:complications* / Q000188:drug therapy; D004435:Eating; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D015438:Health Behavior; D006801:Humans; D007407:Interviews as Topic; D016014:Linear Models; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000628:therapy*; D010349:Patient Compliance; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D000928:Antidepressive Agents