title: Human rhinovirus causes severe infection in preterm infants.
abstract: Data of 11 infants (median gestational age and birth weight 30 weeks and 1520 g, respectively) with severe human rhinovirus infection (HRV) are described. Nine of 11 (82%) were preterm infants and 7 of these 9 (78%) became infected during their stay in the neonatal intensive care unit. All infants presented with respiratory distress and all needed respiratory support for a median of 6 days. Radiologic findings included perihilar streakiness, atelectasis, focal consolidation, and hyperinflation. The diagnosis of HRV infection was made by real-time polymerase chain reaction in nasopharyngeal aspirate. All infants recovered from their HRV infection. HRV can cause severe disease in preterm infants requiring respiratory support.
authors.affiliation: Department of Neonatology, University Medical Center, Utrecht, The Netherlands.
authors.forename: Renée O
authors.initials: RO
authors.lastname: van Piggelen
authors.forename: Anton M
authors.initials: AM
authors.lastname: van Loon
authors.forename: Tanette G
authors.initials: TG
authors.lastname: Krediet
authors.forename: Malgorzata A
authors.initials: MA
authors.lastname: Verboon-Maciolek
mesh_terms: D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000503:physiopathology* / Q000821:virology; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data; D008171:Lung Diseases / Q000503:physiopathology* / Q000821:virology; D009305:Nasopharynx / Q000821:virology; D010850:Picornaviridae Infections / Q000503:physiopathology* / Q000821:virology; D016133:Polymerase Chain Reaction / Q000379:methods; D012229:Rhinovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D012720:Severity of Illness Index