title: Frontal skull craniotomy combined with moderate-dose radiotherapy effectively ameliorate a rare case of non-secretory, multiple myeloma with orbital involvement.
abstract: BACKGROUND
  Orbital infiltration in patients with multiple myeloma is a rare condition, with less than 50 cases reported in the medical literature. Most patients undergo conservative treatment because multiple myeloma is a disseminated systemic disease.
  
  
  METHODS
  A 43-year-old male subject with multiple myeloma and long-term survival presented with orbital involvement. The subject lacked the typical features and poor prognostic factors associated with multiple myeloma, such as renal failure, hypercalcemia, and paraprotein in the serum and urine. The orbital computed tomographic scan revealed the tumor encasing the optic nerve, but without prominent bony destruction. Therefore, a frontal skull craniotomy with an epidural entrance to the orbital space was performed, to completely extirpate the orbital mass. The surgical procedure was followed by moderate-dose radiation therapy. After 32 months of follow-up care, the subject is doing well with excellent local control.
  
  
  CONCLUSIONS
  Although the effectiveness and applicability of this approach remains to be determined, this case report demonstrates that accurate and early detection combined with local surgical treatment and appropriate radio/chemotherapy, can be applied to effectively extend an orbital multiple myeloma patient's life.
authors.affiliation: Department of Neurosurgery, Shin Kong Memorial Hospital, Taipei, Taiwan. komdms@yahoo.com.tw
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Ko
authors.forename: Ching-Lin
authors.initials: CL
authors.lastname: Chen
authors.forename: Kwan-Hwa
authors.initials: KH
authors.lastname: Chi
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D003399:Craniotomy; D019583:Dose Fractionation, Radiation; D042241:Early Diagnosis; D005624:Frontal Bone / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000150:complications / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D009918:Orbital Neoplasms / Q000150:complications / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D011879:Radiotherapy Dosage; D014057:Tomography, X-Ray Computed