title: Transposable elements in gene regulation and in the evolution of vertebrate genomes.
abstract: Repetitive DNA and in particular transposable elements have been intimately linked to eukaryotic genomes for millions of years. Once overlooked for being only a collection of selfish debris and a nuisance for sequence assembly, genomic repeats are now being recognized as a key driving force in genome evolution. Indeed, by changing the DNA landscape of genomes, transposable elements have been a rich source of innovation in genes, regulatory elements and genome structures. In this review, I will focus on recent advances that demonstrate that genomic repeats have had a global impact on vertebrate gene regulatory networks. I will also summarize results that show how transposable elements have been a major catalyst of structural rearrangements throughout evolution.
authors.affiliation: Genome Institute of Singapore, Singapore 138672, Singapore. bourque@gis.a-star.edu.sg
authors.forename: Guillaume
authors.initials: G
authors.lastname: Bourque
mesh_terms: D000818:Animals; D004251:DNA Transposable Elements; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D014714:Vertebrates / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements