title: Patient profiling in cartilage regeneration: prognostic factors determining success of treatment for cartilage defects.
abstract: BACKGROUND
  Cartilage therapy for focal articular lesions has been implemented for more than a decade, and it is becoming increasingly available. What is still lacking, however, is analysis of patient characteristics to help improve outcome or select patients for specific treatment.
  
  
  OBJECTIVE
  To analyze the prognostic value of patient age and defect size, age, and location on clinical outcome 3 years after cartilage therapy.
  
  
  METHODS
  Cohort study; Level of evidence, 3.
  
  
  METHODS
  Fifty-five patients (age, 35 +/- 9 years) were randomly selected from a prospective database. Each had a traumatic knee injury, each was treated for a focal cartilage lesion, and each was assessed with the Knee injury and Osteoarthritis Outcome Score (KOOS) 3 years after surgery. Patient characteristics (ie, patient age and defect size, age, and location) were tested for valid inclusion in the regression model. Multiple linear regression was used to determine which variables influenced clinical improvement. Binary KOOS scores were generated on the basis of age-matched healthy patients and assessed in a logistic regression analysis.
  
  
  RESULTS
  Normality tests confirmed normal distribution for each variable (P < .05). Defect size did not influence clinical improvement (P > .05). Clinical outcome regarding the treatment of medial defects was better than that of the lateral defects (10.38-25.26 points for the different KOOS subscales; P < .05). The KOOS improvement from baseline was better for patients > or =30 years compared with patients > or =30 years (7.31-29.24 points for the different KOOS subscales; P < .05). Patients with defects <24 months were more likely to report the age-matched healthy reference KOOS (odds ratio, 1.8-4.0; P < .05).
  
  
  CONCLUSIONS
  This study illustrates the influence of patient age and defect location and age on clinical outcome 3 years after treatment of a focal cartilage lesion in patients with a traumatic knee injury.
authors.affiliation: Orthopaedic Surgeon, Department of Orthopaedics, University Medical Centre, Utrecht, The Netherlands.
authors.forename: Tommy S
authors.initials: TS
authors.lastname: de Windt
authors.forename: Joris E J
authors.initials: JE
authors.lastname: Bekkers
authors.forename: Laura B
authors.initials: LB
authors.lastname: Creemers
authors.forename: Wouter J A
authors.initials: WJ
authors.lastname: Dhert
authors.forename: Daniël B F
authors.initials: DB
authors.lastname: Saris
mesh_terms: D000293:Adolescent; D000328:Adult; D002356:Cartilage / Q000502:physiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007718:Knee Injuries / Q000601:surgery*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012038:Regeneration; D011795:Surveys and Questionnaires; D013548:Sweden; D055815:Young Adult