Effect of dehydroepiandrosterone sulfate on the concentrations of thyroxine and triiodothyronine in rats after single or repeated cold exposure.
Repeated cold exposure (4 degrees C) was followed an increase in the concentrations of total thyroxine, free thyroxine, and total triiodothyronine in blood plasma of male rats, while single cold exposure was accompanied by a significant increase only in the concentrations of total triiodothyronine and free thyroxine. After administration of dehydroepiandrosterone sulfate (30 mg/kg), the increase in total thyroxine and total triiodothyronine concentrations became more pronounced after repeated cold exposure, but not after single cold exposure. Dehydroepiandrosterone sulfate did not affect the concentration of free thyroxine after single and repeated cold exposure.
Saryg
S K
SK
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Grigoreva
T A
TA
Obut
T A
TA
Dementeva
T U
TU
D000818:Animals; D003080:Cold Temperature; D019314:Dehydroepiandrosterone Sulfate / Q000494:pharmacology*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; D019314:Dehydroepiandrosterone Sulfate; D013974:Thyroxine