title: Chemical composition of endemic Centaurea austro-anatolica and studies of its antimicrobial activity against multi-resistant bacteria.
abstract: Hexane, chloroform, ethyl acetate and ethanolic extracts of the aerial parts of Centaurea austro-anatolica Hub.-Mor. (Asteraceae) were evaluated against microorganisms, including multiresistant bacteria, using a paper disc diffusion method. The chloroform extract exhibited significant antibacterial activity toward all bacteria tested. The chemical composition of the chloroform extract was determined by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The major compounds of the extract were caryophyllene oxide (21.32 %), spathulenol (10.86 %), n-tricosanol (9.58 %) and geranyl isovalerate (8.71 %).
authors.affiliation: Department of Biology, Faculty of Arts and Sciences, Mugla University, 48121 Kotekli-Mugla, Turkey. ayselugur@hotmail.com
authors.forename: Aysel
authors.initials: A
authors.lastname: Ugur
authors.forename: Nurdan
authors.initials: N
authors.lastname: Sarac
authors.forename: Ozgur
authors.initials: O
authors.lastname: Ceylan
authors.forename: M Emin
authors.initials: ME
authors.lastname: Duru
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D031179:Centaurea / Q000737:chemistry; D002725:Chloroform / Q000737:chemistry; D052978:Disk Diffusion Antimicrobial Tests; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D002725:Chloroform