Are HLA DQB1 alleles correlated with breast cancer histopronostic parameters in Tunisia?
BACKGROUND
Tumor cells express surface structures different from normal cells. These structures may be recognized by the immune system, which ensure anti-tumoral surveillance. Antigenic presentation requires HLA molecules role. Since, these molecules are encoded by a high polymorphic system, immune response can be modulated according to HLA genotype. So, HLA polymorphism could be correlated with tumor escape from anti-tumor immunosurveillance.


OBJECTIVE
We have aimed to search for possible associations between HLA DQB1 alleles and the histoprognostical parameters in breast cancer in the Tunisian population.


METHODS
DQB1 alleles were determined by PCR-SSO molecular typing in 100 healthy matched and unrelated Tunisian female and 87 Tunisian women with breast cancer.


RESULTS
Allelic distribution between the two studied groups showed no significant associations between this locus and the occurrence, the EE grade and the lymph node invasion of breast cancer in the Tunisian population.


CONCLUSIONS
This result may be explained by the fact that cancer is a multifactoral disease due to several interacting factors that might change from one population to another.
Baccar
Amal
A
Laboratoire de Génétique, Immunologie et Pathologies Humaines, Faculté des sciences de Tunis.
Loueslati
Besma Yacoubi
BY
Troudi
Wafa
W
Hmida
Slama
S
Dridi
Amel
A
Jridi
Afef
A
Mrad
Karima
K
Ben Romdhane
Khaled
K
Ben Ammar Elgaaied
Amel
A
D000328:Adult; D000368:Aged; D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D014416:Tunisia
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen