Sorting out endosomes in the WASH.
Two new studies published in this issue of Developmental Cell by Derivery et al. and Gomez and Billadeau reveal that WASH (Wiskott-Aldrich syndrome protein and SCAR homolog) activates Arp2/3 on endosomes and plays a critical role in the fission of tubules that serve as transport intermediates during endosome sorting.
Bear
James E
JE
HHMI, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA. jbear@email.unc.edu
D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism; D000818:Animals; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D021381:Protein Transport; D051316:Wiskott-Aldrich Syndrome Protein / Q000378:metabolism*
D051376:Actin-Related Protein 2-3 Complex; D051316:Wiskott-Aldrich Syndrome Protein