Mitochondrial-targeted fluorescent probes for reactive oxygen species.
As the primary consumers of oxygen within all aerobic organisms, mitochondria are a major source of cellular reactive oxygen species (ROS) derived from the in vivo chemistry of oxygen metabolism. Mitochondrial ROS have been traditionally implicated in aging and in a variety of pathologies, including cancer, neurodegeneration, and diabetes, but recent studies also link controlled mitochondrial ROS fluxes to cell regulation and signaling events. Progress in the development of mitochondrial-targeted fluorescent small-molecule indicators that detect specific ROS with high selectivity offers a promising approach for interrogating mitochondrial ROS production, trafficking, and downstream biological effects.
Dickinson
Bryan C
BC
Department of Chemistry, University of California, Berkeley, CA 94720, USA.
Srikun
Duangkhae
D
Chang
Christopher J
CJ
D005456:Fluorescent Dyes / Q000737:chemistry / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D057054:Molecular Imaging / Q000379:methods*; D008970:Molecular Weight; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism*
D005456:Fluorescent Dyes; D017382:Reactive Oxygen Species