title: Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.
abstract: The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed.
authors.affiliation: Inst. Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, Vienna 1060, Austria.
authors.forename: Igor
authors.initials: I
authors.lastname: Beseda
authors.forename: Laszlo
authors.initials: L
authors.lastname: Czollner
authors.forename: Priti S
authors.initials: PS
authors.lastname: Shah
authors.forename: Rupesh
authors.initials: R
authors.lastname: Khunt
authors.forename: Rawindra
authors.initials: R
authors.lastname: Gaware
authors.forename: Paul
authors.initials: P
authors.lastname: Kosma
authors.forename: Christian
authors.initials: C
authors.lastname: Stanetty
authors.forename: Maria Carmen
authors.initials: MC
authors.lastname: Del Ruiz-Ruiz
authors.forename: Hassan
authors.initials: H
authors.lastname: Amer
authors.forename: Kurt
authors.initials: K
authors.lastname: Mereiter
authors.forename: Thierry
authors.initials: T
authors.lastname: Da Cunha
authors.forename: Alex
authors.initials: A
authors.lastname: Odermatt
authors.forename: Dirk
authors.initials: D
authors.lastname: Classen-Houben
authors.forename: Ulrich
authors.initials: U
authors.lastname: Jordis
mesh_terms: D042842:11-beta-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D018360:Crystallography, X-Ray; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D008659:Metabolic Diseases / Q000188:drug therapy*; D008958:Models, Molecular
chemical_list: D042842:11-beta-Hydroxysteroid Dehydrogenases; D006034:Glycyrrhetinic Acid