title: Ghost cell odontogenic carcinoma arising in calcifying odontogenic cyst.
abstract: A case of exceptionally rare odontogenic malignant tumor, called ghost cell odontogenic carcinoma, is described. The tumor was considered to be derived from calcifying odontogenic cyst, which had been resected 5 years before. In the present resected specimen, cellular atypia, mitotic activity, Ki-67 labeling index, and p53 positivity were all increased in comparison with the initially resected specimen. This is a valuable case in which malignant transformation from calcifying odontogenic cyst to ghost cell odontogenic carcinoma was proven by the histopathologic and immunohistochemical findings. Pathologists should be aware of this rare entity.
authors.affiliation: Department of Pathology, Saitama Medical University International Medical Center, Saitama 350-1298, Japan. utaroh-motosugi@nifty.com
authors.forename: Utaroh
authors.initials: U
authors.lastname: Motosugi
authors.forename: Ikuko
authors.initials: I
authors.lastname: Ogawa
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yoda
authors.forename: Takahiro
authors.initials: T
authors.lastname: Abe
authors.forename: Masashi
authors.initials: M
authors.lastname: Sugasawa
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Murata
authors.forename: Masanori
authors.initials: M
authors.lastname: Yasuda
authors.forename: Takaki
authors.initials: T
authors.lastname: Sakurai
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Michio
authors.initials: M
authors.lastname: Shimizu
mesh_terms: D000293:Adolescent; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008441:Maxillary Neoplasms / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009808:Odontogenic Tumors / Q000473:pathology*; D016159:Tumor Suppressor Protein p53
chemical_list: D016159:Tumor Suppressor Protein p53