Synthesis of surface modified mesoporous materials via co-assemble route and their drug release properties.
A series of mesostructured Mn-MCM-41 composites were synthesized via a co-assembly route with tetraethylorthosilicate (TEOS) and manganese sulfate (MnSO4) as silica and manganese sources, respectively. And a model drug of cephanone was introduced via physical adsorption process into the channels of mesoporous silica, which could be used as the Mn-MCM-41 type mesoporous silica-based drug controlled-release delivery system. XRD, TEM, FT-IR, EDS and N2 adsorption-desorption were used to characterize the structural and textural properties of Mn-MCM-41 composites. The investigations showed that the addition of a small amount of manganese species was favorable for the long-range ordered structure of the mesoporous composites, whereas the ordered mesostructure was partially or completely distorted when the loaded manganese increased. The characterizations of cephanone loaded Mn-MCM-41 and in vitro release studies showed that the in vitro releases of cephanone in the ordered mesoporous materials follow an anomalous non-Fick's transport, and the impregnated manganese species had great influences on the release rate of cephanone from mesopores.
Wang
Yi
Y
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002, Jiangsu, PR China.
Zhu
Jun
J
Han
Jie
J
Guo
Rong
R
D001826:Body Fluids / Q000737:chemistry*; D002511:Cephalosporins / Q000008:administration & dosage / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D046911:Macromolecular Substances / Q000737:chemistry; D008345:Manganese / Q000737:chemistry*; D008422:Materials Testing; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
D002511:Cephalosporins; D004337:Drug Carriers; D046911:Macromolecular Substances; C100066:cephanone; D008345:Manganese; D012822:Silicon Dioxide