[The clinical study of using Pingyangmycin of high concentration to treat vascular malformation in oral and maxillofacial region].
OBJECTIVE
To evaluate the clinical effect of using high concentration Pingyangmycin to treat vascular malformation in oral and maxillofacial region.


METHODS
One hundred and fourteen patients with venous malformation in oral and maxillofacial region (50 males and 64 females, age range: 12-76 years) were treated in our department from 2002 to 2008. The lesions ranged in size from 2.0cmx1.5cm to 15cmx10cm. Pingyangmycin (about 8mg/3mL) was injected into the center or periphery of the venous malformation, the injection was repeated every 15 to 30 days when necessary, and may be conducted for 1-5 times. Based on clinical data, retrospective analysis was carried out for the patients who had been followed up for 0.5-5 years after the last treatment. The scale of the results was graded to excellent, good, fair, and poor.


RESULTS
The curative rate of subcutaneous venous malformation and mucosal venous malformation was 92% and 96%, respectively.


CONCLUSIONS
It can be concluded that Pingyangmycin injection at high concentration is safe and effective in the treatment of venous malformation in oral and maxillofacial region.
Gong
Da-dong
DD
Department of Oral and Maxillofacial Surgery, China Medical University, Shenyang, Liaoning Province, China. gongdadong1108@163.com
Wang
Xu-kai
XK
D000293:Adolescent; D000328:Adult; D000368:Aged; D001761:Bleomycin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002648:Child; D005145:Face / Q000098:blood supply; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000098:blood supply; D012189:Retrospective Studies; D054079:Vascular Malformations; D055815:Young Adult
D001761:Bleomycin; C025703:bleomycetin