title: Therapy-related acute myeloid leukemia with 11q23 abnormality coexisting with refractory metastatic Ewing sarcoma: report of a case and review of the literature.
abstract: Intensified chemotherapy is one of the strategies currently used in the treatment of children with metastatic Ewing sarcoma. However, the increasing dose intensity has not significantly improved the event-free survival. We report a patient who initially presented with localized Ewing sarcoma and later developed metastatic disease that required dose-intensified chemotherapy. The patient's Ewing sarcoma remained refractory to treatment despite continuous intensified chemotherapy and was complicated by a therapy-related acute myeloid leukemia with 11q23 abnormality. Examination of bone marrow at the last clinical follow up demonstrated both acute myeloid leukemia and residual metastatic Ewing sarcoma.
authors.affiliation: Department of Pathology, University of New Mexico, Albuquerque, NM 87102, USA.
authors.forename: Heath D
authors.initials: HD
authors.lastname: Worcester
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Vasef
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D014408:Biomarkers, Tumor / Q000378:metabolism; D001853:Bone Marrow / Q000473:pathology; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D002880:Chromosomes, Human, Pair 11; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced* / Q000235:genetics / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D018365:Neoplasm, Residual / Q000473:pathology; D012512:Sarcoma, Ewing / Q000188:drug therapy* / Q000235:genetics / Q000556:secondary; D014034:Toes / Q000473:pathology / Q000601:surgery; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor