Relationship between plasma folate and homocysteine concentrations in alcoholics according to liver enzyme activity.
The aim of this study was to evaluate the relationship between folate and homocysteine levels in alcoholics taking into consideration the liver enzyme activity as sensitive markers of hepatocellular injury. Folate and homocysteine concentrations did not differ between alcoholics classified according to the liver enzyme activity. The association between folate and homocysteine levels exists in the alcoholics with normal liver enzyme activity and in the controls. Therefore, we concluded that before the liver hepatocellular injury due to alcohol abuse, the correlation between folate and homocysteine concentrations in alcoholics exists as in the healthy controls. In the presence of hepatocellular injury, the association disappears.
Cylwik
Bogdan
B
Department of Biochemical Diagnostics, Medical University, Bialystok, Poland. cylwikb@umwb.edu.pl
Chrostek
Lech
L
Daniluk
Marta
M
Supronowicz
Zbigniew
Z
Szmitkowski
Maciej
M
D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D057229:Alcoholics; D000437:Alcoholism / Q000097:blood* / Q000201:enzymology; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005492:Folic Acid / Q000097:blood*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008107:Liver Diseases / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000097:blood
D015415:Biomarkers; D006710:Homocysteine; D005492:Folic Acid; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase