Fetal and maternal angiogenic/anti-angiogenic factors in normal and preeclamptic pregnancy.
Few studies evaluated angiogenic/anti-angiogenic factors and endothelial (dys)function in both maternal and umbilical cord blood (UCB) in preeclampsia (PE). We aimed to clarify the role of placental growth factor (PlGF), vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor 1 (VEGFR-1) and tissue plasminogen activator (tPA), by evaluating them in maternal and UCB in 42 normal and 46 preeclamptic (PEc) cases. In PE, maternal and UCB PlGF were significantly lower; maternal VEGF, sVEGFR-1 and tPA were significantly higher. In UCB, sVEGFR-1 and tPA were significantly higher in PEc cases, while VEGF and PlGF were significantly lower. A significant correlation between maternal and UCB sVEGFR-1, and between sVEGFR-1 and tPA both in maternal and UCB, was observed in PEc cases. In maternal and UCB circulation in PE, a close interaction seems to exist between endothelial dysfunction and angiogenesis disturbance, and sVEGFR-1 seems to play a central role in those disturbances.
Catarino
Cristina
C
Instituto Biologia Molecular Celular (IBMC), Universidade Porto, Porto, Portugal. tinacris_cat@hotmail.com
Rebelo
Irene
I
Belo
Luís
L
Rocha
Susana
S
Castro
Elisabeth B
EB
Patrício
Belmiro
B
Quintanilha
Alexandre
A
Santos-Silva
Alice
A
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005333:Fetus / Q000098:blood supply* / Q000378:metabolism / Q000503:physiopathology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D018919:Neovascularization, Physiologic / Q000502:physiology; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*; D055815:Young Adult
C000608036:PGF protein, human; D011257:Pregnancy Proteins; D042461:Vascular Endothelial Growth Factor A; D000072483:Placenta Growth Factor; D040281:Vascular Endothelial Growth Factor Receptor-1; D010959:Tissue Plasminogen Activator