[Accomodation process: ABO-incompatible liver transplantation. Report of one case].
We report a 33 year-old female with a diagnosis of halothane-induce fulminant hepatic failure who was subjected to a liver transplant with an ABO-incompatible graft. The patient received a therapeutic protocol that included total plasma exchange, splenectomy and quadruple immunosuppression. After 5 years, the patient remains asymptomatic and with normal liver enzymes, while she has been treated with low dose of immunosuppressive drugs. This case demonstrates an example of how the immunological process of accommodation opens the possibility of using ABO-incompatible organs as a definitive grafts.
Castro
Lorena
L
Departamento de Medicina, Hospital San Borja-Arriarán, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Yarur
Andrés
A
Segovia
Roberto
R
Ponce
Rodrigo
R
Uribe
Mario
M
Ferrario
Mario
M
Buckel
Erwin
E
Iturriaga
Hernán
H
D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D001787:Blood Group Incompatibility / Q000276:immunology*; D005260:Female; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D017114:Liver Failure, Acute / Q000097:blood* / Q000601:surgery; D016031:Liver Transplantation / Q000276:immunology / Q000379:methods; D016896:Treatment Outcome
D000017:ABO Blood-Group System