title: Compete globally, bud locally.
abstract: How cells generate a single axis of polarity for mating, division, and movement is unknown. In this issue, Howell et al. (2009) use a synthetic biology approach to demonstrate that rapid competition for a soluble signaling component (Bem1) is essential to ensure a unique axis of polarity in budding yeast.
authors.affiliation: Cardiovascular Research Institute and Department of Biochemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Houk
authors.forename: Arthur
authors.initials: A
authors.lastname: Millius
authors.forename: Orion D
authors.initials: OD
authors.lastname: Weiner
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D016764:Cell Polarity; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D020846:cdc42 GTP-Binding Protein, Saccharomyces cerevisiae / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D029701:Saccharomyces cerevisiae Proteins; C073129:BEM1 protein, S cerevisiae; D020846:cdc42 GTP-Binding Protein, Saccharomyces cerevisiae