A novel composite drug delivery system: honokiol nanoparticles in thermosensitive hydrogel based on chitosan.
In this article, a novel composite drug delivery system, honokiol nanoparticles in biodegradable hydrogels based on chitosan (CS) and beta-glycerophosphate (beta-GP), was prepared. CS/beta-GP solution was liquid at room temperature and turned into gel as temperature increased. With increase in beta-GP concentration, the sol-gel transition temperature decreased accordingly. Honokiol nanoparticles with diameter of about 30 nm were prepared by emulsion solvent evaporation method. The sol-gel transition temperature of CS/beta-GP system decreased as F-127 presented in honokiol nanoparticles. In vitro release profiles were studied, the results showed that honokiol could be slowly released from CS/beta-GP gel over at least 2 weeks and the release rate was greatly influenced by initial drug loading. The described injectable hydrogels based on chitosan (CS) and beta-glycerophosphate (beta-GP) might have potential application as local drug delivery for honokiol.
Li
XingYi
X
State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
Zheng
XiuLing
X
Wei
XiaWei
X
Guo
Gang
G
Gou
MaLing
M
Gong
ChangYang
C
Wang
XianHuo
X
Dai
Mei
M
Chen
LiJuan
L
Wei
YuQuan
Y
Qian
ZhiYong
Z
D001713:Biphenyl Compounds; D048271:Chitosan; D002851:Chromatography, High Pressure Liquid; D016503:Drug Delivery Systems; D020100:Hydrogels; D017705:Lignans; D018625:Microscopy, Atomic Force; D053758:Nanoparticles; D013696:Temperature; D000498:Allyl Compounds; D010636:Phenols
D001713:Biphenyl Compounds; D048271:Chitosan; D020100:Hydrogels; D017705:Lignans; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols