title: Iatrogenic, sulfonamide-induced hypothyroid crisis in a Labrador Retriever.
abstract: This case report describes a sulfonamide-induced hypothyroid crisis in a 4-year-old Labrador Retriever bitch. Empirical therapy with high-dose trimethoprim-sulfamethoxazole for 10 days produced signs of weakness, ataxia and mental depression and the clinicopathological results supported hypothyroid-induced central nervous system depression. Short-term levothyroxine sodium therapy led to complete resolution of all clinical signs and follow-up thyroid hormone assays ruled out underlying thyroid pathology. This case report is the first to highlight this potentially life-threatening manifestation of sulfonamide-induced hypothyroidism. Sulfonamide combinations are widely used antimicrobials in veterinary medicine and early recognition of this syndrome is critical.
authors.affiliation: Department of Clinical Sciences, Kansas State University, Manhattan, 66506-5701, USA. kbrenner@vet.ksu.edu
authors.forename: K
authors.initials: K
authors.lastname: Brenner
authors.forename: K
authors.initials: K
authors.lastname: Harkin
authors.forename: T
authors.initials: T
authors.lastname: Schermerhorn
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D005260:Female; D007049:Iatrogenic Disease / Q000662:veterinary*; D009230:Myxedema / Q000139:chemically induced / Q000662:veterinary*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination