title: Short-term follow-up of palpable breast lesions with benign imaging features: evaluation of 375 lesions in 320 women.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the feasibility of short-term follow-up of palpable masses that have benign imaging features.
  
  
  METHODS
  The cases of all women with round, oval, or lobular palpable masses with circumscribed margins and homogeneous ultrasound echotexture for which short-term follow-up was recommended from July 1997 through December 2003 were retrospectively identified. Evaluation was by ultrasound and/or mammography and focused clinical examination. Outcome was assessed with imaging or clinical follow-up lasting at least 12 months. The cancer incidence for palpable lesions was compared with that for nonpalpable lesions recommended for short-term follow-up.
  
  
  RESULTS
  In 379 women, 443 palpable masses with benign features for which short-term follow-up was recommended were identified. Outcome data were available on 375 masses in 320 women. Lesions were evaluated with mammography and ultrasound (n = 186) or ultrasound alone (n = 189). Masses were typically identified only with ultrasound (n = 258, 68.8%); were oval (n = 275, 73.3%), of equal density to normal breast tissue on mammograms (n = 95 on 117 mammograms, 81.2%), and hypoechoic (n = 336 in 372 ultrasound examinations, 90.3%); and were prospectively believed to be fibroadenoma (n = 304, 81.1%). Eighty-five lesions (22.7%) were biopsied soon after evaluation, and one 1.5-mm ductal carcinoma in situ was diagnosed. At follow-up (mean, 2.7 years), 26 lesions (6.9%) had grown. Twenty-four of the 26 lesions were biopsied, and no cancer was diagnosed. The overall cancer prevalence was similar for palpable (0.3%) and nonpalpable (1.6%) masses. The cost of short-term follow-up was less than that of biopsy.
  
  
  CONCLUSIONS
  Short-term follow-up is a reasonable alternative to biopsy of palpable breast lesions with benign imaging features, particularly for young women with probable fibroadenoma.
authors.affiliation: Department of Radiology, University of Virginia, Box 800170, Charlottesville, VA 22908.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Harvey
authors.forename: Brandi T
authors.initials: BT
authors.lastname: Nicholson
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Lorusso
authors.forename: Michael A
authors.initials: MA
authors.lastname: Cohen
authors.forename: Viktor E
authors.initials: VE
authors.lastname: Bovbjerg
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D015994:Incidence; D008327:Mammography; D008875:Middle Aged; D010808:Physical Examination; D012189:Retrospective Studies; D016217:Ultrasonography, Mammary