[A hospital-based case-control study on influencing factors of nonalcoholic fatty liver disease].
OBJECTIVE
To investigate the influencing factors of nonalcoholic fatty liver disease (NAFLD).


METHODS
A hospital-based case-control study was conducted in patients with NAFLD and controls without NAFLD in a hospital from January to August in 2007. All data were analyzed by SPSS 13.0 software.


RESULTS
One-way analysis of variance found that the two groups were significantly different in cigarette smoking, alcohol and tea comsumption, movement index, speed of food intake, frequency of social engagement, kinds of edible oil, marine products, family history of NAFLD, hypertension, higher blood sugar, abnormality of blood fat, higher level of ALT, higher level of AST, hyperuricemia, obesity, decrease of high density lipoprotein (HDL), and increase of low density lipoprotein. By non-conditional logistic stepwise regression analysis, 12 of 18 factors were used to construct a model, ten of which were the risk factors and two were protective factors of NAFLD. Risk factors included obesity (OR=6.35), hypertension(OR=3.82), dyslipidemia (OR=2.95), decrease of HDL (OR=2.85), hyperglycemia (OR=2.82), increase of ALT (OR=2.80), hyperuricemia (OR=2.35), HBsAg positive (OR=1.99), family history of fatty liver (OR=1.79) and frequently intake of marine products (OR=1.58), and protective factors included tea drinking (OR=0.72) and exercise (OR=0.90).


CONCLUSIONS
There are many influencing factors of NAFLD, and life styles are the key factors. Genetic background may also play some roles in NAFLD.
Peng
Xian-e
XE
Key Laboratory of Infection and Oncology, Research Center of Molecular Medicine, Fujian Medical University, Fuzhou 350004, China.
Lai
Zhi-shuang
ZS
Lu
Qing-qing
QQ
Lin
Jian-yin
JY
Lin
Xu
X
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005234:Fatty Liver / Q000097:blood / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D005247:Feeding Behavior; D005260:Female; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D016017:Odds Ratio; D012044:Regression Analysis; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
D002784:Cholesterol