Cerebrospinal fluids containing anti-HSP70 autoantibodies from multiple sclerosis patients augment HSP70-induced proinflammatory cytokine production in monocytic cells.
Anti-heat shock protein 70 (HSP70) autoantibodies are found in cerebrospinal fluids (CSF) from patients with multiple sclerosis. These autoantibodies cross-reacted not only with HSP70 and heat shock cognate protein 70 (HSC70), but also with a bacterial homologue, DnaK. CSF with a high anti-HSP70 autoantibody titer enhanced HSP70-induced proinflammatory cytokine and chemokine production in the human monocytic cell line, THP-1. Thus, anti-HSP70 autoantibodies in the CSF of multiple sclerosis patients may play a pathophysiological role in enhancing inflammation.
Yokota
Shin-ichi
S
Department of Microbiology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo 060-8556, Japan.
Chiba
Susumu
S
Furuyama
Hiroyasu
H
Fujii
Nobuhiro
N
D001323:Autoantibodies / Q000134:cerebrospinal fluid* / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens; D016207:Cytokines; D018840:HSP70 Heat-Shock Proteins