title: Therapy of percutaneous infection around craniofacial implants.
abstract: This study sought to develop treatment strategies for managing percutaneous infection around craniofacial implants. The present general pathogen situation together with a bacterial resistance were determined in 57 infected peri-implant sites. Forty-four implants were randomly assigned for wound cleaning and split into three groups-two with local antibiotics of proven efficacy and one with 3% hydrogen peroxide (H2O2). The pathogen spectrum differed depending on the severity of the infection, with Staphylococcus aureus clearly correlated with the degree of inflammation (positive correlation: R = 0.72). It was observed that the use of additional local antibiotics was not superior to conventional wound cleaning with 3% H2O2. It is suggested that sulcus fluid flow rate measurements could serve as a simple and reliable objective parameter for recall examinations.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Pastic Surgery, Fachklinik Hornheide, Münster, Germany. martin.klein@fachklinik-hornheide.de
authors.forename: Martin
authors.initials: M
authors.lastname: Klein
authors.forename: Ilana
authors.initials: I
authors.lastname: Weisz
authors.forename: Christian
authors.initials: C
authors.lastname: Camerer
authors.forename: Horst
authors.initials: H
authors.lastname: Menneking
authors.forename: Doris Maria
authors.initials: DM
authors.lastname: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001414:Bacitracin / Q000627:therapeutic use; D004338:Drug Combinations; D004423:Ear; D005122:Exudates and Transudates; D005137:Eye, Artificial; D005145:Face / Q000601:surgery*; D006801:Humans; D006861:Hydrogen Peroxide / Q000627:therapeutic use; D009355:Neomycin / Q000627:therapeutic use; D009666:Nose; D020273:Orbital Implants; D019919:Prosthesis Implantation / Q000295:instrumentation*; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy*; D013752:Tetracycline / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D001414:Bacitracin; D006861:Hydrogen Peroxide; D013752:Tetracycline; D009355:Neomycin