title: Clotting, immune system, and venous thrombosis in lung adenocarcinoma patients: a prospective study.
abstract: Thrombosis is highly prevalent in cancer patients, being accepted as a bad prognosis marker. The importance of various mechanisms involved in the thrombophilic state of lung cancer patients is not well understood. In this prospective study, involving 109 unselected patients with lung adenocarcinoma, thrombosis was present in 24% of patients and affected survival in a bivariable model. However, in a multivariable evaluation, considering all the factors under study, only LAC and IgM anti-beta(2) GP I modified thrombosis risk, whereas in a Kaplan-Meyer regression model, thrombosis, IL-6, LAC, factor VIII, and IgM anti-beta(2) GP I interfered with patient's survival.
authors.affiliation: Clinical Pathology, Instituto Nacional do Câncer, Praça Cruz Vermelha 23, Centro, Rio de Janeiro, 20230-130, Brazil. edemeisrio@yahoo.com
authors.forename: Ernesto
authors.initials: E
authors.lastname: de Meis
authors.forename: Vera R
authors.initials: VR
authors.lastname: Pinheiro
authors.forename: Mauro M
authors.initials: MM
authors.lastname: Zamboni
authors.forename: Maria Teresa S
authors.initials: MT
authors.lastname: Guedes
authors.forename: Ilda A M
authors.initials: IA
authors.lastname: Castilho
authors.forename: Maria Mercedes K
authors.initials: MM
authors.lastname: Martinez
authors.forename: Marys Stella O
authors.initials: MS
authors.lastname: Leda
authors.forename: Neura P R
authors.initials: NP
authors.lastname: Silveira
authors.forename: Vivian M
authors.initials: VM
authors.lastname: Rumjanek
authors.forename: Roger A
authors.initials: RA
authors.lastname: Levy
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000150:complications* / Q000276:immunology / Q000401:mortality; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000097:blood / Q000150:complications* / Q000276:immunology / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D020246:Venous Thrombosis / Q000097:blood / Q000209:etiology* / Q000276:immunology / Q000401:mortality
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D016207:Cytokines