Antioxidative and hepatoprotective diarylheptanoids from the bark of Alnus japonica.
The present study to evaluate the potential of constituents of the bark of Alnus japonica as a functional food with medicinal properties led to the identification of one new diarylheptanoid, named alusenone (1A), and 11 known ones (1B and 2-11). Their antioxidative and hepatoprotective activities were accessed by, respectively, a TOSC assay and a TBH-induced hepatotoxicity rat model. Mixtures 1, 2-6, 10, and 11 showed good antioxidative and hepatoprotective effects as compared with the positive controls.
Tung
Nguyen Huu
NH
College of Pharmacy, Chungnam National University, Daejeon, Korea.
Kim
Sang Kyum
SK
Ra
Jeong Chan
JC
Zhao
Yu-Zhe
YZ
Sohn
Dong Hwan
DH
Kim
Young Ho
YH
D029661:Alnus / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D036381:Diarylheptanoids / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D051381:Rats
D000975:Antioxidants; D036381:Diarylheptanoids