Microwave-assisted synthesis of 2'-O-aryluridine derivatives.
A new method for the synthesis of 2'-O-aryluridines was developed via the microwave-mediated reaction of 2,2'-anhydrouridine with aromatic alcohols. Aminophenol and aminonaphthol derivatives underwent selective 2'-O-arylation with 2,2'-anhydrouridine to produce 2'-O-(aminoaryl)uridine derivatives. These reactions proved to proceed without the need for any bases or solvents, but better results were obtained by use of N,N-dimethylacetamide (DMA) as the solvent in some cases.
Oeda
Yusuke
Y
Department of Life Science, Tokyo Institute of Technology, J2-12, 4259 Nagatsuta, Midoriku, Yokohama 226-8501, Japan.
Iijima
Yoshihiro
Y
Taguchi
Haruhiko
H
Ohkubo
Akihiro
A
Seio
Khoji
K
Sekine
Mitsuo
M
D000438:Alcohols / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D008872:Microwaves; D015394:Molecular Structure; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
D000438:Alcohols; D014529:Uridine