Enzyme responsive nanocontainers with cyclodextrin gatekeepers and synergistic effects in release of guests.
The cyclodextrin covered porous silica nanoparticles (Si-MPs) exhibited enzyme responsive characteristics. The cyclodextrin gatekeepers on the surface of Si-MPs can be hydrolyzed by a-amylase to release guest molecules from the porous reservoir. The ester linkage in the stalk part of the cyclodextrin gatekeeper can also be cleaved by lipase to release guests from the channel. Our approach would provide a unique methodology for controlled delivery systems.
Park
Chiyoung
C
Department of Polymer Science and Engineering, Inha University, Incheon 402-751, Korea.
Kim
Hyehyeon
H
Kim
Saehee
S
Kim
Chulhee
C
D003505:Cyclodextrins / Q000737:chemistry*; D006868:Hydrolysis; D049329:Nanostructures / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D000516:alpha-Amylases / Q000737:chemistry*
D003505:Cyclodextrins; D012822:Silicon Dioxide; D000516:alpha-Amylases