[Changes in the hemodynamics of rats with immunological liver fibrosis].
OBJECTIVE
To observe the changes in the hemodynamics of rats with immunological liver fibrosis and explore the pathogenesis of "blood stasis" in liver fibrosis.


METHODS
Rat models of liver fibrosis were established by multiple intraperitoneal injections of pig serum. The hematocrit, blood viscosity at the shear rate of 150/s, 30/s, 5/s, and 1/s, serum markers for liver fibrosis, and serum transaminase levels were measured in the control and model rats.


RESULTS
The hematocrit, blood viscosity at different shear rates, hyaluronic acid (HA), laminin (LN), procollagen type III (PCIII), type IV collagen (CIV), glutamic-pyruvic transaminase (ALT) and glutamic-oxaloacetic transaminase (AST) increased significantly in the rats with experimental liver fibrosis appeared as compared with those in the control rats. Positive correlations were noted between blood viscosity at different shear rates and serum concentrations of the fibrosis markers (HA, LN, PCIII, and CIV) in the model rats.


CONCLUSIONS
The changes in the hemodynamics in rats with immunological liver fibrosis suggests the role of "blood stasis" in the pathogenesis of liver fibrosis and provide experimental evidence for therapies to "activate the blood circulation and dissipate blood stasis" for treatment of liver fibrosis.
Lv
Xiao-Yan
XY
College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. jiajia411816@126.com
Liu
Qiang
Q
Sun
Xue-Gang
XG
Chen
Yu-Yao
YY
Hua
He-Yu
HY
Qin
Gui-Qiang
GQ
Zhang
Xu-Fu
XF
Lv
Zhi-Ping
ZP
D000818:Animals; D001809:Blood Viscosity; D003937:Diagnosis, Differential; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D008106:Liver Cirrhosis, Experimental / Q000097:blood* / Q000276:immunology; D008297:Male; D008516:Medicine, Chinese Traditional; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley