Increased yields and simplified purification with a second-generation cobalt catalyst for the oxidative formation of trans-THF rings.
The synthesis of a second-generation cobalt catalyst for the formation of trans-THF products via the Mukaiyama aerobic oxidative cyclization is reported. Two procedures have been developed with the new water-soluble catalyst that give superior yields and greatly simplify purification compared to the previous catalysts.
Palmer
Cory
C
The University of Western Ontario, Department of Chemistry, London, Ontario, N6A 5B7.
Morra
Nicholas A
NA
Stevens
Andrew C
AC
Bajtos
Barbora
B
Machin
Ben P
BP
Pagenkopf
Brian L
BL
D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012995:Solubility; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
D014867:Water; D003035:Cobalt