title: Vestibular function and vertigo control after intratympanic gentamicin for Ménière's disease.
abstract: The aim of this study was to correlate long-term vertigo control with reduction in vestibular function after intratympanic (IT) gentamicin therapy for unilateral Ménière's disease. IT gentamicin injections were given as needed to control vertigo attacks. Vertigo frequency and changes in angular vestibulo-ocular reflex (AVOR) gain (measured using magnetic search coils and manual head thrusts) and caloric weakness were assessed before and after treatment. Better vertigo control after treatment was found with >or=60% reduction in quantitative ipsilateral horizontal semicircular canal AVOR gain from pre-treatment values and/or with caloric unilateral weakness (UW) >50%. However, no correlations were found between the continuous variables of vertigo control and either gain or gain recovery, nor between gain and UW because of the large variability in vertigo control in subjects with lesser reductions in these measures.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287-0910, USA.
authors.forename: Kimanh D
authors.initials: KD
authors.lastname: Nguyen
authors.forename: Lloyd B
authors.initials: LB
authors.lastname: Minor
authors.forename: Charles C
authors.initials: CC
authors.lastname: Della Santina
authors.forename: John P
authors.initials: JP
authors.lastname: Carey
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002150:Caloric Tests; D016009:Chi-Square Distribution; D016208:Databases, Factual; D004333:Drug Administration Routes; D005133:Eye Movements / Q000502:physiology; D005839:Gentamicins / Q000008:administration & dosage*; D019416:Head Movements / Q000502:physiology; D006801:Humans; D008575:Meniere Disease / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D020127:Recovery of Function; D012008:Recurrence; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology; D012044:Regression Analysis; D012665:Semicircular Canals / Q000503:physiopathology; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D014717:Vertigo / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins