Ligands of diltiazem binding site: an overview of some chemotypes.
The diltiazem binding site of L-type calcium channels is the least characterized to date. In this paper, we present some of the available chemotypes that bind to the benzothiazepine binding site: natural compounds, compounds synthesized by varying the benzothiazepine scaffold, and compounds discovered by means of computational approaches.
Budriesi
R
R
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Bologna, Via Belmeloro 6, 40126 Bologna, Italia. roberta.budriesi@unibo.it
Ioan
P
P
Carosati
E
E
Cruciani
G
G
Zhorov
B S
BS
Chiarini
A
A
D001665:Binding Sites; D002121:Calcium Channel Blockers / Q000737:chemistry*; D020746:Calcium Channels, L-Type / Q000737:chemistry / Q000378:metabolism; D003198:Computer Simulation; D004110:Diltiazem / Q000031:analogs & derivatives* / Q000737:chemistry; D008024:Ligands
D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D008024:Ligands; D004110:Diltiazem