title: Mast cell adhesion induces cytoskeletal modifications and programmed cell death in oligodendrocytes.
abstract: In this paper we show that rat peritoneal mast cells (RPMC) adhere to rat oligodendrocytes (ODC) in culture and switch on a bi-directional signal affecting both adhering cell and its target. Following heterotypic interaction, RPMC release granule content and ODC show morphological changes and enter the apoptotic programme. Altogether, these findings indicate that the interaction of MC with ODC could play a role in the mechanism of CNS damage induced by the inflammatory reaction.
authors.affiliation: Department of Life Sciences, University of Trieste, via A. Valerio, 28, 34127, Trieste, Italy.
authors.forename: Nevenka
authors.initials: N
authors.lastname: Medic
authors.forename: Paola
authors.initials: P
authors.lastname: Lorenzon
authors.forename: Francesca
authors.initials: F
authors.lastname: Vita
authors.forename: Elisa
authors.initials: E
authors.lastname: Trevisan
authors.forename: Anna
authors.initials: A
authors.lastname: Marchioli
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Soranzo
authors.forename: Elsa
authors.initials: E
authors.lastname: Fabbretti
authors.forename: Giuliano
authors.initials: G
authors.lastname: Zabucchi
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D015153:Blotting, Western; D002448:Cell Adhesion / Q000276:immunology; D002450:Cell Communication / Q000276:immunology*; D015550:Cell Degranulation / Q000276:immunology; D002478:Cells, Cultured; D003599:Cytoskeleton / Q000648:ultrastructure*; D005455:Fluorescent Antibody Technique; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D009836:Oligodendroglia / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D051381:Rats