Mononuclear copper(II) nitrato complexes with methyl-substituted 4-nitropyridine N-oxide. Physicochemical and cytotoxic characteristics.
Three new complexes, products of the interaction of Cu(NO(3))(2) and methyl-substituted 4-nitropyridine N-oxides were synthesized and characterized by elemental analysis, magnetic, spectroscopic (IR, FIR and EPR), thermal and X-ray methods. The complexes (magnetic moments 1.70-1.81 BM at 300K) of general formula [Cu(H(2)O)(NO(3))(2)L(2)], L=2-methyl-4-nitropyridine N-oxide and [Cu(NO(3))(2) L'(2)], where L'=2,6-dimethyl- and 2,3,6-trimethyl-4-nitropyridine N-oxide were obtained. The compounds were unstable upon dissolution. The X-ray single crystal structure of Cu(II) complex with 2,6-dimethyl-4-nitropyridine N-oxide was determined and analysed. The compounds and free ligands were tested in vitro on the cytotoxic activity against MCF-7 and SW-707 human cancer cell lines. The complexes with 4-nitropyridine N-oxide (a reference) and 2-methyl-4-nitropyridine N-oxide show a significant anti-proliferative activity against studied cell lines. A reciprocal relationship between the activity and the number of methyl groups was observed. Both ligands and complexes are cytotoxic active but to the different cell lines.
Puszko
Aniela
A
Department of Bioorganic Chemistry, Faculty of Industry and Economics, University of Economics, Komandorska St. 118/120, 53-345 Wrocław, Poland.
Krojcer
Anna
A
Pełczynska
Marzena
M
Wietrzyk
Joanna
J
Cieślak-Golonka
Maria
M
Jezierska
Julia
J
Adach
Anna
A
Kubiak
Maria
M
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D006860:Hydrogen Bonding; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D010087:Oxides / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013816:Thermodynamics
D056831:Coordination Complexes; D008024:Ligands; D010087:Oxides; D011725:Pyridines; C052728:4-nitropyridine; D003300:Copper