Systemic analysis of the symbiotic function of Buchnera aphidicola, the primary endosymbiont of the pea aphid Acyrthosiphon pisum.
Buchnera aphidicola is the primary obligate intracellular symbiont of most aphid species. B. aphidicola and aphids have been evolving in parallel since their association started, about 150 Myr ago. Both partners have lost their autonomy, and aphid diversification has been confined to smaller ecological niches by this co-evolution. B. aphidicola has undergone major genomic and biochemical changes as a result of adapting to intracellular life. Several genomes of B. aphidicola from different aphid species have been sequenced in the last decade, making it possible to carry out analyses and comparative studies using system-level in silico methods. This review attempts to provide a systemic description of the symbiotic function of aphid endosymbionts, particularly of B. aphidicola from the pea aphid Acyrthosiphon pisum, by analyzing their structural genomic properties, as well as their genetic and metabolic networks.
Brinza
Lilia
L
UMR203 BF2I, Biologie fonctionnelle insectes et interactions, Université de Lyon, INRA, INSA-Lyon, IFR41, 20, avenue A. Einstein, 69621 Villeurbanne, France.
Viñuelas
José
J
Cottret
Ludovic
L
Calevro
Federica
F
Rahbé
Yvan
Y
Febvay
Gérard
G
Duport
Gabrielle
G
Colella
Stefano
S
Rabatel
Andréane
A
Gautier
Christian
C
Fayard
Jean-Michel
JM
Sagot
Marie-France
MF
Charles
Hubert
H
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001042:Aphids / Q000166:cytology / Q000382:microbiology* / Q000502:physiology; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology; D020635:Buchnera / Q000145:classification / Q000235:genetics / Q000502:physiology*; D002876:Chromosomes, Bacterial / Q000235:genetics; D019143:Evolution, Molecular; D015964:Gene Expression Regulation, Bacterial; D053263:Gene Regulatory Networks; D005798:Genes, Bacterial; D040961:Genetic Drift; D016680:Genome, Bacterial; D023281:Genomics; D053858:Metabolic Networks and Pathways / Q000235:genetics; D018532:Pisum sativum / Q000469:parasitology*; D010802:Phylogeny; D013559:Symbiosis / Q000235:genetics / Q000502:physiology*
D000596:Amino Acids; D001426:Bacterial Proteins