RNAi in X inactivation: contrasting findings on the role of interference.
X inactivation is the process that brings about the dosage equivalence of X-linked genes in females to that of males. This complex process initiated at a very early stage of female embryonic development is orchestrated by long non-coding RNAs transcribed in both sense and antisense orientation. Recent studies present contradicting evidence for the role of small RNAs and RNase III enzyme Dicer in the X inactivation process. In this review, I discuss these results in the overall perspective of X inactivation and gene silencing.
Kota
Satya K
SK
Institute of Molecular Genetics, CNRS, UMR5535, 34293 Montpelier Cedex 5, France. satya.kota@igmm.cnrs.fr
D000818:Animals; D004622:Embryo, Mammalian / Q000201:enzymology; D006657:Histones / Q000378:metabolism; D034622:RNA Interference; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D043244:Ribonuclease III / Q000378:metabolism; D049951:X Chromosome Inactivation / Q000235:genetics*
D006657:Histones; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; C077885:XIST non-coding RNA; D043244:Ribonuclease III