Molecular iodine promoted synthesis of new pyrazolo[3,4-d]pyrimidine derivatives as potential antibacterial agents.
Iodocyclization of 5-amino-1-(2,4-dinitrophenyl)-1H-4-pyrazolcarboxamides with aromatic aldehydes gave a new series of pyrazolo[3,4-d]pyrimidine derivatives in a single step and their antibacterial activity comparable to Streptomycin as reference drug was evaluated.
Bakavoli
Mehdi
M
Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, Vakilabad Blvd 91775-1436 Mashhad, Iran. mbakavoli@yahoo.com
Bagherzadeh
Ghodsieh
G
Vaseghifar
Maryam
M
Shiri
Ali
A
Pordel
Mehdi
M
Mashreghi
Mansour
M
Pordeli
Parvaneh
P
Araghi
Maryam
M
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002384:Catalysis; D003500:Cyclization; D007455:Iodine / Q000737:chemistry*; D010084:Oxidation-Reduction; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D011743:Pyrimidines; D007455:Iodine