Use of a multibotanical (Nutrafem) for the relief of menopausal  vasomotor symptoms: a double-blind, placebo-controlled study.
OBJECTIVE
This study aimed to compare the efficacy and safety of a multibotanical (Nutrafem) with those of placebo for the treatment of menopausal vasomotor symptoms.


METHODS
In this phase III, double-blind, randomized, placebo-controlled study, 159 postmenopausal women experiencing at least 21 vasomotor symptoms per week were treated with Nutrafem (Bionutra Pte Ltd, Singapore) or a matched placebo for 12 weeks. Treatment outcome was evaluated by the change from baseline in the average weekly number of vasomotor symptoms.


RESULTS
At the end of the study, Nutrafem reduced the number of vasomotor symptoms by 46% from baseline, and this is significantly superior to placebo (26% from baseline; P = 0.020). Forty-three percent of women taking Nutrafem experienced an at least 50% reduction in the number of symptoms compared with 6% of women taking placebo (P = 0.021; number needed to treat = 2.7). There were no group differences in adverse events, laboratory values, and gynecological data.


CONCLUSIONS
Nutrafem is an effective botanical treatment for vasomotor symptoms in postmenopausal women.
Garcia
Joan Tan
JT
St Luke's Medical Center, Quezon City, Philippines.
Gonzaga
Florante
F
Tan
Delfin
D
Ng
Toon Yaa
TY
Oei
Pau Ling
PL
Chan
Cathryn W B
CW
D000284:Administration, Oral; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D031283:Eucommiaceae; D007887:Fabaceae; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D017698:Postmenopause; D012639:Seeds; D012846:Singapore; D016896:Treatment Outcome; D014666:Vasomotor System / Q000187:drug effects*
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts