A Novel 5'-Iodonucleoside Allows Efficient Nonenzymatic Ligation of Single-stranded and Duplex DNAs.
A new iodothymidine phosphoramidite enables the placement of a 5'-iodide into oligonucleotides; the iodide is stable to ammonia deprotection and allows nonenzymatic ligations of DNA.
Xu
Yanzheng
Y
Department of Chemistry, University of Rochester, Rochester, NY 14627.
Kool
Eric T
ET