title: Multiple immune abnormalities in a patient with idiopathic CD4+ T-lymphocytopenia.
abstract: Idiopathic CD4+ T-lymphocytopenia (ICL) is a new disease entity characterized by CD4+ T-lymphocyte depletion without evidence of HIV infection. We report a 27-year-old ICL patient with a long history of multiple immune abnormalities. His CD4+ T-lymphocyte count started to decrease after generalized lymphadenopathy of an unknown cause at age 3. He satisfied the criteria for ICL at age 9, and the decreased CD4+ T-lymphocyte count persisted for more than 18 years. This is probably the first childhood-onset ICL case in which the trigger event for the development was known together with the patient's autoimmune background.
authors.affiliation: Department of Laboratory Medicine, Nagasaki University Hospital, Nagasaki. y-yamada@nagasaki-u.ac.jp
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Yamada
authors.forename: Masahiko
authors.initials: M
authors.lastname: Okada
authors.forename: Akira
authors.initials: A
authors.lastname: Kamitamari
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Moriuchi
authors.forename: Masanori
authors.initials: M
authors.lastname: Yanai
authors.forename: Osamu
authors.initials: O
authors.lastname: Hano
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Tsukasaki
authors.forename: Kazuto
authors.initials: K
authors.lastname: Tsuruda
authors.forename: Hiroo
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Katsunori
authors.initials: K
authors.lastname: Yanagihara
authors.forename: Shimeru
authors.initials: S
authors.lastname: Kamihira
mesh_terms: D000328:Adult; D006801:Humans; D007154:Immune System Diseases / Q000150:complications*; D008297:Male; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000175:diagnosis* / Q000276:immunology