Amphiphilic poly{[alpha-maleic anhydride-omega-methoxy-poly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery.
In this study, the transdermal drug delivery properties of D,L-tetrahydropalmatine (THP)-loaded amphiphilic poly{[alpha-maleic anhydride-omega-methoxy-poly(ethylene glycol)]-co-(ethyl cyanoacrylate)} (PEGECA) graft copolymer nanoparticles (PEGECAT NPs) were evaluated by skin penetration experiments in vitro. The transdermal permeation experiments in vitro were carried out in Franz diffusion cells using THP-loaded PEGECAT NPs as the donor system. Transmission electron microscopy and Fourier transform infrared spectroscopy were used to characterize the receptor fluid. The results indicate that the THP-loaded PEGECAT NPs are able to penetrate the rat skin. Fluorescent microscopy measurements demonstrate that THP-loaded PEGECAT NPs can penetrate the skin not only via appendage routes but also via epidermal routes. This nanotechnology has potential application in transdermal drug delivery.
Xing
Jinfeng
J
Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People's Republic of China.
Deng
Liandong
L
Li
Jun
J
Dong
Anjie
A
D000279:Administration, Cutaneous; D000818:Animals; D001600:Berberine Alkaloids / Q000008:administration & dosage / Q000493:pharmacokinetics; D003487:Cyanoacrylates / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry*; D016503:Drug Delivery Systems; D066298:In Vitro Techniques; D008299:Maleic Anhydrides / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D050997:Nanomedicine; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D010539:Permeability; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D051381:Rats; D012867:Skin / Q000033:anatomy & histology / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared; D013501:Surface-Active Agents / Q000737:chemistry
D001600:Berberine Alkaloids; D003487:Cyanoacrylates; D004337:Drug Carriers; D008299:Maleic Anhydrides; D011108:Polymers; D013501:Surface-Active Agents; C016683:polymaleic anhydride; D011092:Polyethylene Glycols; C014215:tetrahydropalmatine; C028210:monomethoxypolyethylene glycol