title: A new cytotoxic flavonoid from the fruit of Sinopodophyllum hexandrum.
abstract: Constituents of the fruit of Sinopodophyllum hexandrum (Royle) Ying (Sinopodophylli Fructus) were investigated. A new flavonoid, 8,2'-diprenylquercetin 3-methyl ether along with 9 known compounds were isolated and identified. Among them, the new compound 8,2'-diprenylquercetin 3-methyl ether exhibited cytotoxic activities against MDA-231 and T47D breast cancer cell lines, quercetin, kaempferol and rutin were isolated from Sinopodophylli Fructus for the first time.
authors.affiliation: Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Kong
authors.forename: Jun-Jun
authors.initials: JJ
authors.lastname: Xiao
authors.forename: Shu-Cong
authors.initials: SC
authors.lastname: Meng
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Dong
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Ge
authors.forename: Ru-Feng
authors.initials: RF
authors.lastname: Wang
authors.forename: Ming-Ying
authors.initials: MY
authors.lastname: Shang
authors.forename: Shao-Qing
authors.initials: SQ
authors.lastname: Cai
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D028141:Berberidaceae / Q000737:chemistry*; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D005638:Fruit; D006801:Humans; D044949:Kaempferols / Q000302:isolation & purification; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D012431:Rutin / Q000302:isolation & purification
chemical_list: C554121:8,2'-diprenylquercetin 3-methyl ether; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D044949:Kaempferols; D010936:Plant Extracts; D012431:Rutin; C006552:kaempferol; D011794:Quercetin