Application of mesenchymal stromal cells in urological diseases.
The application of stem cells and their use in tissue-engineering approaches is emerging in clinical therapeutic intervention strategies. The use of adult stem cells, either autologous or allogenic, does not raise ethical concerns, in contrast to embryonic stem cells. Mesenchymal stromal cells (MSCs) can be easily obtained from bone marrow or from adipose tissue and further expanded in vitro. Due to their differentiation capacity, MSCs are very attractive for tissue engineering purposes. Furthermore, MSCs secrete a variety of mediators that have beneficial effects on the regenerating tissue. In this review we give an insight into stem cell hierarchy, define the properties of MSCs and summarize recent reports of their administration in urological diseases.
Montzka
Katrin
K
Department of Urology, RWTH University Aachen, Aachen, Germany. kmontzka@ukaachen.de
Heidenreich
Axel
A
D000328:Adult; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D017154:Stromal Cells / Q000637:transplantation*; D023822:Tissue Engineering / Q000379:methods; D014570:Urologic Diseases / Q000628:therapy*