Identification of Western equine encephalitis virus structural proteins that confer protection after DNA vaccination.
DNA vaccines encoding different portions of the structural proteins of western equine encephalitis virus were tested for the efficacy of their protection in a 100% lethal mouse model of the virus. The 6K-E1 structural protein encoded by the DNA vaccine conferred complete protection against challenge with the homologous strain and limited protection against challenge with a heterologous strain.
Gauci
Penelope J
PJ
Biological Countermeasures, Human Protection and Performance Division, Defence Science & Technology Organisation, 506 Lorimer St., Fishermans Bend, VIC 3207, Australia. Penny.Gauci@dsto.defence.gov.au
Wu
Josh Q H
JQ
Rayner
George A
GA
Barabé
Nicole D
ND
Nagata
Leslie P
LP
Proll
David F
DF
D000818:Animals; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D004667:Encephalitis Virus, Western Equine / Q000235:genetics / Q000276:immunology*; D004683:Encephalomyelitis, Equine / Q000517:prevention & control*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D016019:Survival Analysis; D019444:Vaccines, DNA / Q000276:immunology*; D015678:Viral Structural Proteins / Q000235:genetics / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
D000956:Antigens, Viral; D019444:Vaccines, DNA; D015678:Viral Structural Proteins; D014765:Viral Vaccines