Causes and histopathology of ascending aortic disease in children and young adults.
BACKGROUND
Ascending aortic diseases (aneurysms, dissections, and stenosis) and associated aortic valve disease are rare but important causes of morbidity and mortality in children and young adults. Certain genetic causes, such as Marfan syndrome and congenital bicuspid aortic valve disease, are well known. However, other rarer genetic and nongenetic causes of aortic disease exist.


METHODS
We performed an extensive literature search to identify known causes of ascending aortic pathology in children and young adults. We catalogued both aortic pathologies and other defining systemic features of these diseases.


RESULTS
We describe 17 predominantly genetic entities that have been associated with thoracic aortic disease in this age group.


CONCLUSIONS
While extensive literature on the common causes of ascending aortic disease exists, there is a need for better histologic documentation of aortic pathology in rarer diseases.
Jain
Deepali
D
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dietz
Harry C
HC
Oswald
Gretchen L
GL
Maleszewski
Joseph J
JJ
Halushka
Marc K
MK
D000293:Adolescent; D000784:Aortic Dissection / Q000209:etiology / Q000473:pathology; D001014:Aortic Aneurysm / Q000209:etiology / Q000473:pathology; D001018:Aortic Diseases / Q000209:etiology* / Q000235:genetics / Q000473:pathology*; D001024:Aortic Valve Stenosis / Q000209:etiology / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009154:Mutation; D055815:Young Adult