title: All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease.
abstract: Retinoic acid, an essential factor derived from vitamin A, has been shown to have a variety of functions including roles as an antioxidant and in cellular differentiation. Since oxidative stress and dedifferentiation of neurons appear to be common pathological elements of a number of neurodegenerative disorders, we speculated that retinoic acid may offer therapeutic promise. In this vein, recent compelling evidence indicates a role of retinoic acid in cognitive activities and anti-amyloidogenic properties. Here, we review the actions of retinoic acid that indicate that it may have therapeutic properties ideally served for the treatment of neurodegenerative diseases such as Alzheimer's disease.
authors.affiliation: Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. hxl204@case.edu
authors.forename: Hyun-Pil
authors.initials: HP
authors.lastname: Lee
authors.forename: Gemma
authors.initials: G
authors.lastname: Casadesus
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Zhu
authors.forename: Hyoung-gon
authors.initials: HG
authors.lastname: Lee
authors.forename: George
authors.initials: G
authors.lastname: Perry
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Gustaw-Rothenberg
authors.forename: Alan
authors.initials: A
authors.lastname: Lerner
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology*; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D018696:Neuroprotective Agents; D014212:Tretinoin