title: Study on the different expression of molecular markers between cardiac cancer and distal gastric cancer and their correlations with clinicopathological features.
abstract: OBJECTIVE
  Currently, few studies have reported the different expression of molecular markers between distal gastric cancer and cardiac cancer. Here, we sought to make an investigation about it by a retrospective analysis.
  
  
  METHODS
  The expression of 8 proteins, including epidermal growth factor receptor, glutathione S-transferase pi (GST-pi), cyclin D1, Neu/Her-2, C-myc, p53, p27 and p21, were evaluated in 110 cases with cardiac cancer and 101 cases with distal gastric cancer who underwent curative surgery at the Cancer Hospital, Fudan University, in 2005 by immunohistochemistry method.
  
  
  RESULTS
  The TNM stage, differentiation grade, invasion depth and lymph node metastasis were significantly different between cardiac cancer and distal gastric cancer. p21 (p = 0.034), Neu (p = 0.017), and GST-pi (p = 0.003) were expressed in relatively higher levels in cardiac cancer than in distal gastric cancer. Furthermore, the clinical pathological parameters were significantly correlated with the expression of molecules mentioned above.
  
  
  CONCLUSIONS
  Different molecular mechanisms may be involved in the tumorigenesis and development of cardiac cancer and distal gastric cancer.
authors.affiliation: Department of Abdominal Surgery, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Yan-wei
authors.initials: YW
authors.lastname: Ye
authors.forename: Hong
authors.initials: H
authors.lastname: Fu
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhou
authors.forename: Chun-yan
authors.initials: CY
authors.lastname: Du
authors.forename: Bai-zhou
authors.initials: BZ
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.forename: Ying-qiang
authors.initials: YQ
authors.lastname: Shi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002299:Cardia / Q000378:metabolism* / Q000473:pathology; D019938:Cyclin D1 / Q000378:metabolism; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D051549:Glutathione S-Transferase pi / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009439:Neuraminidase / Q000378:metabolism; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate; D014157:Transcription Factors / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D004268:DNA-Binding Proteins; C116115:MYCBP protein, human; D014157:Transcription Factors; D019938:Cyclin D1; D050760:Cyclin-Dependent Kinase Inhibitor p27; D051549:Glutathione S-Transferase pi; D066246:ErbB Receptors; C403285:NEU2 protein, human; D009439:Neuraminidase