title: Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton.
abstract: Unexpected substituent on the well-known morphine skeleton is described to be account for highly selective and potent mu opioid ligands, which is strongly connected to substituted aromatic groups on this omitted 8alpha-position.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Tao
authors.forename: Yun
authors.initials: Y
authors.lastname: Tang
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Xu
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Fu
authors.forename: Xing-Hai
authors.initials: XH
authors.lastname: Wang
authors.forename: Bo
authors.initials: B
authors.lastname: Chao
authors.forename: Wei
authors.initials: W
authors.lastname: Sheng
authors.forename: Qiong
authors.initials: Q
authors.lastname: Xie
authors.forename: Zhui-Bai
authors.initials: ZB
authors.lastname: Qiu
authors.forename: Jing-Gen
authors.initials: JG
authors.lastname: Liu
mesh_terms: D018360:Crystallography, X-Ray; D006801:Humans; D008024:Ligands; D008968:Molecular Conformation; D009020:Morphine / Q000737:chemistry*; D011485:Protein Binding; D017450:Receptors, Opioid, mu / Q000378:metabolism*; D013797:Thebaine / Q000737:chemistry
chemical_list: D008024:Ligands; D017450:Receptors, Opioid, mu; D013797:Thebaine; D009020:Morphine