Formulation of effects of atropine, pralidoxime and magnesium sulfate on cardiac tissue levels of nitric oxide, malondialdehyde and glutathione in organophosphate poisoning using artificial neural network.
Anticholinesterase poisoning is an important health problem in our country, and a complete understanding of its underlying mechanisms is essential for the emergency physician. So, this study focused on two purposes. First one was aimed to investigate the biochemical analysis to determine the tissue levels of malondialdehyde (MDA), glutathione and nitric oxide (NO). Secondly, it was planned to model and formulate the effects of some drugs on cardiac tissues levels of NO, MDA and glutathione in acute organophosphate poisoning in rats by the application of neural network based on experimental results. It has been planned to determine whether artificial neural network (ANN) is appropriate tool to analyze and formulate it. As a result, it has been considered that ANN can be effectively used to model NO, MDA and glutathione level. The performances of ANN formulation versus target experimental values are found to be quite high. It is concluded that, proposed NN models are also presented as simple explicit mathematical functions for further use by researchers.
Togun
Necla
N
Department of Mechanical Engineering, University of Gaziantep, 27310 Gaziantep, Turkey. nkara@gantep.edu.tr
Kose
Ataman
A
Gunay
Nurullah
N
Tarakcioglu
Mehmet
M
Demiryurek
Abdullah T
AT
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D000931:Antidotes / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D004006:Dichlorvos / Q000506:poisoning*; D005978:Glutathione / Q000032:analysis; D007306:Insecticides / Q000506:poisoning*; D008278:Magnesium Sulfate / Q000494:pharmacology; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009206:Myocardium / Q000737:chemistry*; D016571:Neural Networks, Computer; D009569:Nitric Oxide / Q000032:analysis; D011041:Poisoning / Q000188:drug therapy; D011220:Pralidoxime Compounds / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D000889:Anti-Arrhythmia Agents; D000931:Antidotes; D007306:Insecticides; D018727:Muscarinic Antagonists; D011220:Pralidoxime Compounds; D009569:Nitric Oxide; D008315:Malondialdehyde; D008278:Magnesium Sulfate; D001285:Atropine; D004006:Dichlorvos; D005978:Glutathione; C028797:pralidoxime