title: Association analysis between functional polymorphism of the rs4606 SNP in the RGS2 gene and antipsychotic-induced Parkinsonism in Japanese patients with schizophrenia: results from the Juntendo University Schizophrenia Projects (JUSP).
abstract: Antipsychotic-induced extrapyramidal symptoms (AIEPSs) are commonly recognized side effects of typical 1st generation antipsychotics, and considerable variability is seen in the susceptibility of individual patients to AIEPSs. Regulator of G-protein signaling 2 (RGS2) proteins regulate intracellular signaling and second messenger activation of molecules including dopamine, serotonin, and acetylcholine receptors, all of which appear to be involved in the pathophysiology of AIEPSs. Previous studies have shown an association between AIEPSs in schizophrenia and RGS2, especially the minor G allele of single nucleotide polymorphism (SNP) rs4606 (+2971C>G) in RGS2, and have suggested a possible protective effect by the G allele on AIEPSs. In this study, we investigated whether the rs4606 SNP in RGS2 alone also showed an effect on AIEPSs by utilizing the Drug-Induced Extrapyramidal Symptom Scale (DIEPSS) in 103 Japanese patients with schizophrenia. In the assumed G allele recessive model, sialorrhea and total Parkinsonism scores were significantly higher in subjects with the GG genotype than in subjects with other genotypes. Other clinical variables were not significantly different among the various genotype groups. Controlling for clinical variables as covariates, a one-way analysis of covariance found no association between rs4606 genotypes and DIEPSS scores. Taken together, these results, although preliminary, suggest that rs4606 does not affect AIEPSs in Japanese subjects.
authors.affiliation: Juntendo University Schizophrenia Projects (JUSP), Department of Psychiatry, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Higa
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohnuma
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Maeshima
authors.forename: Tokiko
authors.initials: T
authors.lastname: Hatano
authors.forename: Ryo
authors.initials: R
authors.lastname: Hanzawa
authors.forename: Nobuto
authors.initials: N
authors.lastname: Shibata
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Sakai
authors.forename: Toshihito
authors.initials: T
authors.lastname: Suzuki
authors.forename: Heii
authors.initials: H
authors.lastname: Arai
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020734:Parkinsonian Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D020710:RGS Proteins / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics*; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents; D020710:RGS Proteins; C087182:RGS2 protein, human