[Modeling of the polycystic ovary syndrome].
The objective of the study was to create a model of the polycystic ovary syndrome (PCOS) developing in puberty. 17beta-estradiol 1.5 mg as gel was once applied to the preshaved abdominal skin of 15 female Wistar rats aged 30 days weighing 30-35 g, who had no regular 4-day estrous cycles. Then the animals were fixed for 10-15 minutes until the agent was completely absorbed. For a month, the animals were daily immobilized for 15 minutes. After achieving their sexual maturity, the animals were slaughtered and their ovarian tissue was sampled for histological analysis. The performed study revealed that all 15 (100%) animals had characteristic morphological changes suggesting the development of the polycystic ovary syndrome.
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D000818:Animals; D004195:Disease Models, Animal; D004958:Estradiol / Q000009:adverse effects* / Q000494:pharmacology; D004967:Estrogens / Q000009:adverse effects* / Q000494:pharmacology; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D010053:Ovary / Q000473:pathology*; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced* / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D004967:Estrogens; D004958:Estradiol