Potential role for ligand-gated ion channels after seizure-induced neurogenesis.
Epileptic seizures result in an increased generation of new neurons in the dentate gyrus of the adult mammalian hippocampus. The role of these seizure-induced newborn neurons in the process of epileptogenesis remains largely unknown. Recent work, however, suggests an aberrant incorporation of newborn cells into the existing hippocampal network in such a way that they promote hippocampal hyperexcitability. In the present review, we discuss current knowledge about the possible role of seizure-induced newly generated neurons and the putative involvement of ligand-gated ion channels in the process of epileptogenesis.
Swijsen
Ann
A
BIOMED Research Institute, Hasselt University and transnationale Universiteit Limburg, B-3590 Diepenbeek, Belgium.
Hoogland
Govert
G
Rigo
Jean-Michel
JM
D000818:Animals; D018891:Dentate Gyrus / Q000166:cytology / Q000378:metabolism; D004827:Epilepsy / Q000503:physiopathology*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D008024:Ligands; D055495:Neurogenesis / Q000502:physiology*
D007473:Ion Channels; D008024:Ligands