First application of dynamic infrared imaging in boron neutron capture therapy for cutaneous malignant melanoma.
OBJECTIVE
The purpose of this study is to assess the potential of dynamic infrared imaging (DIRI) as a functional, noninvasive technique for evaluating the skin acute toxicity and tumor control within the framework of the Argentine boron neutron capture therapy (BNCT) program for cutaneous malignant melanoma.


METHODS
Two patients enrolled in the Argentine phase I/II BNCT clinical trial for cutaneous malignant melanoma were studied with DIRI. An uncooled infrared camera, providing a video output signal, was employed to register the temperature evolution of the normal skin and tumor regions in patients subjected to a mild local cooling (cold stimulus). In order to study the spatial correlation between dose and acute skin reactions, three-dimensional representations of the superficial dose delivered to skin were constructed and cameralike projections of the dose distribution were coregistered with visible and infrared images.


RESULTS
The main erythematous reaction was observed clinically between the second and fifth week post-BNCT. Concurrently, with its clinical onset, a reactive increase above the basal skin temperature was observed with DIRI in the third week post-BNCT within regions that received therapeutic doses. Melanoma nodules appeared as highly localized hyperthermic regions. 2 min after stimulus, these regions reached a temperature plateau and increased in size. Temperature differences with respect to normal skin up to 10 degrees C were observed in the larger nodules.


CONCLUSIONS
Preliminary results suggest that DIRI, enhanced by the application of cold stimuli, may provide useful functional information associated with the metabolism and vasculature of tumors and inflammatory processes related to radiation-induced changes in the skin as well. These capabilities are aimed at complementing the clinical observations and standard imaging techniques, such as CT and Doppler ultrasound.
Santa Cruz
G A
GA
Departamento de Instrumentación y Control, Comisión Nacional de Energía Atómica, Avenida del Libertador 8250, 1429 Buenos Aires, Argentina. santacr@cnea.gov.ar
González
S J
SJ
Bertotti
J
J
Marín
J
J
D000368:Aged; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D007259:Infrared Rays; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000532:radiotherapy*; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy*; D013817:Thermography / Q000379:methods*; D016896:Treatment Outcome