Peptide thioester synthesis through N-->S acyl-transfer: application to the synthesis of a beta-defensin.
Peptide thioesters readily prepared through N-->S acyl transfer of a specific C-terminal motif provide access to biologically active mini-proteins using native chemical ligation.
Kang
Jaskiranjit
J
Department of Chemistry, University College London, 20 Gordon Street, London, UK WC1H 0AJ.
Reynolds
Natalie L
NL
Tyrrell
Christine
C
Dorin
Julia R
JR
Macmillan
Derek
D
D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013997:Time Factors; D023083:beta-Defensins / Q000138:chemical synthesis* / Q000737:chemistry*
D004952:Esters; D013438:Sulfhydryl Compounds; D023083:beta-Defensins