Invited review: festschrift edition of neurosurgery peripheral nervous system as a conduit for delivering therapies for diabetic neuropathy, amyotrophic lateral sclerosis, and nerve regeneration.
In this review, we describe how therapies that promote axonal regeneration and neuronal protection can complement surgery for a successful functional restoration in peripheral nerve disorders. We discuss the advantages of peripheral drug delivery and the role of the neurosurgeon in the precise delivery of molecular therapies to surgically inaccessible structures. Strategies for enhancing uptake and retrograde transport of therapeutics, including gene therapy, are emphasized as conduits for delivery of therapeutics. Finally, candidate therapeutic proteins and genes are discussed in the context of application to degenerative disorders of the nervous system, including nerve injury, peripheral neuropathy, and amyotrophic lateral sclerosis.
Federici
Thais
T
Department of Neurosurgery, Emory University, Atlanta, Georgia 30322, USA.
Boulis
Nicholas M
NM
D000690:Amyotrophic Lateral Sclerosis / Q000503:physiopathology / Q000601:surgery*; D000818:Animals; D001370:Axonal Transport / Q000235:genetics; D003929:Diabetic Neuropathies / Q000503:physiopathology / Q000601:surgery*; D005727:Ganglia, Spinal / Q000187:drug effects / Q000378:metabolism / Q000601:surgery; D018014:Gene Transfer Techniques / Q000639:trends*; D006801:Humans; D009416:Nerve Regeneration / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000627:therapeutic use; D010525:Peripheral Nerves / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D010523:Peripheral Nervous System Diseases / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D020127:Recovery of Function / Q000235:genetics
D009419:Nerve Tissue Proteins