Rab35--a vesicular traffic-regulating small GTPase with actin modulating roles.
The Rab family of GTPases are regulators of eukaryotic vesicular membrane traffic, while modulation of actin dynamics is a function conventionally associated with the Rho family of GTPases. Rab35 is a Rab protein with both plasma membrane and endosomal localization, and has been implicated in diverse processes that include T-cell receptor recycling, oocyte yolk protein recycling and cytokinesis. Rab35 regulates neurite outgrowth in neuronal-like cells, and can induce protrusions even in typically non-adherent Jurkat T-cells. Recent evidence indicates that Rab35's activity, particularly the ability to mediate protrusive outgrowths, is due to its direct influence on actin dynamics. This can occur via activation of the Rho family of GTPases, or through the engagement of its effector fascin, an actin bundling protein.
Chua
Christelle En Lin
CE
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Lim
Yi Shan
YS
Tang
Bor Luen
BL
D000199:Actins / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology*; D048749:Cytokinesis; D006801:Humans; D019169:Jurkat Cells; D009369:Neoplasms / Q000201:enzymology; D021381:Protein Transport; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D022161:Transport Vesicles / Q000201:enzymology*; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
D000199:Actins; D011948:Receptors, Antigen, T-Cell; C511183:RAB35 protein, human; D020691:rab GTP-Binding Proteins