Isolated ptosis as acute ophthalmoplegia without ataxia, positive for anti-GQ1b immunoglobulin G.
Anti-GQ1b IgG antibody syndrome comprises a wide range of diseases presenting with ophthalmoplegia and ataxia. Anti-GQ1b antibodies have been strongly associated in the literature with Miller Fisher Syndrome, with acute ophthalmoplegia associated with Guillain-Barré syndrome, and with isolated ophthalmoplegia. Acute ophthalmoplegia presents as various combinations of external and internal ophthalmoplegia. Reported here is a novel case of isolated ptosis as a manifestation of ophthalmoplegia. The present finding of bilateral ptosis and areflexia with anti-GQ1b IgG antibody positivity helps confirm the existence of the syndrome. Further research is needed on diagnosis and treatment.
Jindal
Geetanjali
G
Department of Pediatrics, Government Medical College, Sector 32, Chandigarh, India. geetanjali_jindal@yahoo.com
Parmar
Veena R
VR
Gupta
Vipul K
VK
D000208:Acute Disease; D001259:Ataxia / Q000175:diagnosis; D001323:Autoantibodies / Q000097:blood*; D020274:Autoimmune Diseases of the Nervous System / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D001763:Blepharoptosis / Q000175:diagnosis* / Q000276:immunology* / Q000628:therapy; D002675:Child, Preschool; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D008297:Male; D009886:Ophthalmoplegia / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D012018:Reflex; D013577:Syndrome; D016896:Treatment Outcome
D001323:Autoantibodies; D005732:Gangliosides; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; C039129:GQ1b ganglioside