Human pancreatic islet progenitor cells demonstrate phenotypic plasticity in vitro.
Phenotypic plasticity is a phenomenon that describes the occurrence of 2 or more distinct phenotypes under diverse conditions. This article discusses the work carried out over the past few years in understanding the potential of human pancreatic islet-derived progenitors for cell replacement therapy in diabetes. The phenotypic plasticity exhibited by pancreatic progenitors during reversible epithelial-to-mesenchymal transition (EMT) and possible role of microRNAs in regulation of this process is also presented herein.
Dalvi
Maithili P
MP
Stem Cells and Diabetes Section, Lab 12, National Center for Cell Science, Ganeshkhind Road, Pune 411 007, India.
Umrani
Malati R
MR
Joglekar
Mugdha V
MV
Hardikar
Anandwardhan A
AA
D018929:Cell Culture Techniques; D002454:Cell Differentiation; D049109:Cell Proliferation; D044127:Epigenesis, Genetic; D006801:Humans; D007515:Islets of Langerhans / Q000166:cytology / Q000502:physiology*; D010641:Phenotype; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*