Excitatory amino acid involvement in dendritic spine formation, maintenance and remodelling.
In the central nervous system, most excitatory synapses occur on dendritic spines, which are small protrusions from the dendritic tree. In the mature cortex and hippocampus, dendritic spines are heterogeneous in shape. It has been shown that the shapes of the spine can affect synapse stability and synaptic function. Dendritic spines are highly motile structures that can undergo actin-dependent shape changes, which occur over a time scale ranging from seconds to tens of minutes or even days. The formation, remodelling and elimination of excitatory synapses on dendritic spines represent ways of refining the microcircuitry in the brain. Here I review the current knowledge on the effects of modulation of AMPA and NMDA ionotropic glutamate receptors on dendritic spine formation, motility and remodelling.
McKinney
R Anne
RA
Department of Pharmacology and Therapeutics, Bellini Life Science Building, McGill University, Montreal, H3G 0B1, Canada. anne.mckinney@mcgill.ca
D000818:Animals; D001921:Brain / Q000502:physiology / Q000648:ultrastructure; D049229:Dendritic Spines / Q000502:physiology* / Q000648:ultrastructure*; D018846:Excitatory Amino Acids / Q000378:metabolism*; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D018091:Receptors, AMPA / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*
D018846:Excitatory Amino Acids; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate