title: Asymmetric total synthesis of (+)-crassalactone D.
abstract: The asymmetric total synthesis of (+)-crassalactone D (4), a naturally occurring antitumor agent, has been achieved by employing an oxidative spirocyclization of furan 11 as the key step. Two close analogues, 7-epi-crassalactone D (14) and 5-epi-7-epi-crassalactone D (15), also have been prepared in the course of the synthesis of (+)-crassalactone D.
authors.affiliation: Medicinal Chemistry Department, AMRI, 26 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098, USA. zhicai.yang@amriglobal.com
authors.forename: Zhicai
authors.initials: Z
authors.lastname: Yang
authors.forename: Phung
authors.initials: P
authors.lastname: Tang
authors.forename: Jolicia F
authors.initials: JF
authors.lastname: Gauuan
authors.forename: Bruce F
authors.initials: BF
authors.lastname: Molino
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D013141:Spiro Compounds; C545739:crassalactone D; C039281:furan