title: Serum levels of reproductive hormones and ultrasonographic monitoring of ovarian follicles in female cloned dogs.
abstract: This study investigated the reproductive characteristics in 2 cloned female beagle dogs (Clones A and B) during proestrus and early estrus. The pre-ovulatory estradiol peak occurred 2 days before the pre-ovulatory luteinizing hormone (LH) surge, while the follicle stimulating hormone surge started concomitantly with the LH surge in both cloned dogs. Serum progesterone levels increased during proestrus and estrus and its concentration on the day of the LH surge was 3.59 and 2.71 ng/ml in Clones A and B, respectively. Gradual follicular growth was observed by ultrasonography during proestrus. Although the numbers are limited, these cloned female dogs showed normal ranges of reproductive hormone levels and follicular changes during proestrous and early estrous stages of the cycle.
authors.affiliation: Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
authors.forename: So Gun
authors.initials: SG
authors.lastname: Hong
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Oh
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Park
authors.forename: Jung Taek
authors.initials: JT
authors.lastname: Kang
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Jung Hee
authors.initials: JH
authors.lastname: Yoon
authors.forename: Jin Hwa
authors.initials: JH
authors.lastname: Chang
authors.forename: Min Kyu
authors.initials: MK
authors.lastname: Kim
authors.forename: Goo
authors.initials: G
authors.lastname: Jang
authors.forename: Byeong Chun
authors.initials: BC
authors.lastname: Lee
mesh_terms: D000818:Animals; D019976:Cloning, Organism; D004285:Dogs / Q000033:anatomy & histology* / Q000502:physiology*; D004958:Estradiol / Q000097:blood; D030762:Estrous Cycle / Q000097:blood* / Q000502:physiology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D006080:Ovarian Follicle / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D011374:Progesterone / Q000097:blood; D014463:Ultrasonography
chemical_list: D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone