title: Prenatal diagnosis of alobar holoprosencephaly, by use of ultrasound and magnetic resonance imaging in the second trimester.
abstract: We describe a case concerning alobar holoprosencephaly and proboscis diagnosed at 20+3 weeks gestation during routine sonographic scanning. The internal neural and craniofacial malformations of the fetus were confirmed using magnetic resonance imaging (MRI). Amniocentesis demonstrated trisomy 13 of a male fetus.
authors.affiliation: Department of Obstetrics and Gynecology, Amphia Hospital Breda, Breda, The Netherlands.
authors.forename: Marieke
authors.initials: M
authors.lastname: Huibers
authors.forename: Dimitri N M
authors.initials: DN
authors.lastname: Papatsonis
mesh_terms: D000328:Adult; D005260:Female; D016142:Holoprosencephaly / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis / Q000379:methods*; D011859:Radiography; D016216:Ultrasonography, Prenatal