Evaluation of novel epothilone analogues by means of a common pharmacophore and a QSAR pseudoreceptor model for taxanes and epothilones.
Forli
Stefano
S
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via Alcide de Gasperi 2, 53100 Siena, Italy.
Manetti
Fabrizio
F
Altmann
Karl-Heinz
KH
Botta
Maurizio
M
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D034261:Epothilones / Q000737:chemistry* / Q000494:pharmacology; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology; D011485:Protein Binding; D021281:Quantitative Structure-Activity Relationship; D043823:Taxoids / Q000737:chemistry* / Q000494:pharmacology; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism
D000970:Antineoplastic Agents; D034261:Epothilones; D043823:Taxoids; D014404:Tubulin; D017239:Paclitaxel; C093788:epothilone B