title: Preoperative assessment of complete tumour resection by magnetic resonance imaging in patients undergoing pelvic exenteration.
abstract: OBJECTIVE
  To evaluate whether preoperative magnetic resonance imaging (MRI) allows prediction of complete tumour resection in patients planned for pelvic exenteration (PE).
  
  
  METHODS
  Data of all patients treated by PE at a gynaecologic cancer centre between 6/1999 and 5/2005 were studied retrospectively. Preoperative MRI scans were re-analysed blindly with respect to invasion of neighbouring organs, muscular pelvic side wall, vessels and lymph nodes by an experienced team of radiologist and gynaecologic oncologist, finally also giving estimation whether complete removal of tumour would be feasible.
  
  
  RESULTS
  43 patients were identified: all of them underwent PE. The histopathological investigation of the exenteration specimen demonstrated microscopic complete resection status in 20 cases (46.5%). None of the investigated parameter showed a correlation to complete resection of tumour. Sensitivity for final microscopic results relative to preoperative prediction by radiographic findings was 85%, specificity was 52%. The positive predictive value for tumour-free status was 60% (17/28), the negative 80% (12/15).
  
  
  CONCLUSIONS
  Preoperative MRI cannot predict the surgical outcome with sufficient accuracy, hence on its own is inappropriate for prediction of complete tumour resection and final histological margin status in patients undergoing PE.
authors.affiliation: Kaiserswerther Diakonie, Florence Nightingale Hospital, Obstetrics and Gynaecology, Duesseldorf, Germany. dr.forner@gmx.de
authors.forename: Dirk Michael
authors.initials: DM
authors.lastname: Forner
authors.forename: Ansgar
authors.initials: A
authors.lastname: Meyer
authors.forename: Bjoern
authors.initials: B
authors.lastname: Lampe
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005833:Genital Neoplasms, Female / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010385:Pelvic Exenteration; D011300:Preoperative Care / Q000379:methods*; D011379:Prognosis; D012189:Retrospective Studies