COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.
It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.
Tomlinson
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IP
Molecular and Population Genetics, Nuffield Department of Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.
Dunlop
M
M
Campbell
H
H
Zanke
B
B
Gallinger
S
S
Hudson
T
T
Koessler
T
T
Pharoah
P D
PD
Niittymäki
I
I
Niittymäkix
I
I
Tuupanen
S
S
Tuupanenx
S
S
Aaltonen
L A
LA
Hemminki
K
K
Lindblom
A
A
Försti
A
A
Sieber
O
O
Lipton
L
L
van Wezel
T
T
Morreau
H
H
Wijnen
J T
JT
Devilee
P
P
Matsuda
K
K
Nakamura
Y
Y
Castellví-Bel
S
S
Ruiz-Ponte
C
C
Castells
A
A
Carracedo
A
A
Ho
J W C
JW
Sham
P
P
Hofstra
R M W
RM
Vodicka
P
P
Brenner
H
H
Hampe
J
J
Schafmayer
C
C
Tepel
J
J
Schreiber
S
S
Völzke
H
H
Lerch
M M
MM
Schmidt
C A
CA
Buch
S
S
Moreno
V
V
Villanueva
C M
CM
Peterlongo
P
P
Radice
P
P
Echeverry
M M
MM
Velez
A
A
Carvajal-Carmona
L
L
Scott
R
R
Penegar
S
S
Broderick
P
P
Tenesa
A
A
Houlston
R S
RS
D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D019683:Penetrance; D011110:Polymorphism, Genetic; D011379:Prognosis; D012306:Risk; D012307:Risk Factors