Uncoupling ribosome biogenesis regulation from RNA polymerase I activity during herpes simplex virus type 1 infection.
The ribosome is the central effector of protein synthesis, and its synthesis is intimately coordinated with that of proteins. At present, the most documented way to modulate ribosome biogenesis involves control of rDNA transcription by RNA polymerase I (RNA Pol I). Here we show that after infection of human cells with herpes simplex virus type 1 (HSV-1) the rate of ribosome biogenesis is modulated independently of RNA Pol I activity by a dramatic change in the rRNA maturation pathway. This process permits control of the ribosome biogenesis rate, giving the possibility of escaping ribosomal stress and eventually allowing assembly of specialized kinds of ribosomes.
Belin
Stéphane
S
Centre National de la Recherche Scientifique (CNRS), Université de Lyon, Lyon F-69003, France.
Kindbeiter
Karine
K
Hacot
Sabine
S
Albaret
Marie Alexandra
MA
Roca-Martinez
Jean-Xavier
JX
Thérizols
Gabriel
G
Grosso
Olivier
O
Diaz
Jean-Jacques
JJ
D001483:Base Sequence; D004789:Enzyme Activation; D006367:HeLa Cells; D006561:Herpes Simplex / Q000235:genetics / Q000378:metabolism*; D018259:Herpesvirus 1, Human / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D012318:RNA Polymerase I / Q000378:metabolism* / Q000502:physiology; D012322:RNA Precursors / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional / Q000502:physiology; D012270:Ribosomes / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D012322:RNA Precursors; D012318:RNA Polymerase I