Interleukin-17 kick-starts T helper 1 cell differentiation.
In this issue of Immunity, Lin et al. (2009) implicate interleukin-17 in the regulation of T helper 1 (Th1) cell immunity against Francisella tularensis. These findings add a unique twist to the cytokine regulation of T cell differentiation and function.
Malefyt
Rene de Waal
Rde W
Department of Immunology, Schering-Plough Biopharma, Palo Alto, CA 94304, USA. rene.de.waal.malefyt@spcorp.com
D000818:Animals; D002454:Cell Differentiation; D005604:Francisella tularensis; D020381:Interleukin-17 / Q000378:metabolism*; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology*; D018417:Th1 Cells / Q000166:cytology / Q000276:immunology*
D020381:Interleukin-17