title: [Epistaxis and systemic disease].
abstract: We report the case of a 77-year-old man who presented nasal obstruction sensation and epistaxis. Otorhinolaryngological examination revealed occupation of the left nasal passage and the left maxillary sinus by an inflammatory tumour, the biopsy results of which were inconclusive. While diagnostic tests where being carried out, the patient presented a severe systemic condition consisting mainly of anaemia, acute renal failure, and cavitated diffuse bilateral lung infiltrates. In the light of the results of anti-neutrophilic cytoplasmic antibodies and renal biopsy, Wegener's granulomatosis was diagnosed and treatment for the disease was instituted with a favourable response. Finally, clinical manifestations of Wegener's granulomatosis are reviewed, with especial emphasis on otolaryngologic complaints.
authors.affiliation: Hospital General de Castellón, Universidad de Valencia, Castellón de la Plana, España. brocav@meditex.es <brocav@meditex.es>
authors.forename: Bernardino
authors.initials: B
authors.lastname: Roca
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000473:pathology / Q000628:therapy; D000368:Aged; D000740:Anemia / Q000209:etiology; D001706:Biopsy; D015897:Comorbidity; D003520:Cyclophosphamide / Q000627:therapeutic use; D004844:Epistaxis / Q000209:etiology*; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D015508:Nasal Obstruction / Q000209:etiology*; D010212:Papilloma / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000601:surgery; D006435:Renal Dialysis; D014057:Tomography, X-Ray Computed; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D003520:Cyclophosphamide