[The role of apolipoproteins A-I and A-II in plasma HDL remodeling].
Apolipoprotein (apo) A-I is a key HDL protein participating in the process of reverse cholesterol transport. A small part of plasma apo A-I exists as free protein which is a substrate for generation of discoid HDL precursors, containing small amounts of phospholipids and free cholesterol. The cycling of apo A-I between precursor and mature forms of HDL is an essential element of HDL remodeling in plasma. The second most abundant protein of human HDL is apo A-II, nevertheless, it is present only in about half of the HDL particles in plasma. The mechanism mediating the formation of HDL containing apo A-I and apo A-II is unknown. The role of apo A-II in reverse cholesterol transport generates controversy. Different observations indicate either proatherogenic or proinflammatory properties of apo A-II. Also the participation of apo A-II in plasma HDL remodeling remains unclear. Apo A-II maybe a factor stabilizing HDL particles. This protein may also take part in regulation of VLDL metabolism. The review presents current knowledge concerning participation of apo A-I and apo A-II in plasma HDL remodeling.
Wróblewska
Małgorzata
M
Department of Laboratory Medicine, Medical University of Gdańsk, 7 Debinki St., 80-211 Gdańsk, Poland. wroblew@amg.gda.pl
D000818:Animals; D016632:Apolipoprotein A-I / Q000378:metabolism*; D016633:Apolipoprotein A-II / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000096:biosynthesis / Q000097:blood* / Q000737:chemistry; D006801:Humans; D008099:Liver / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D008076:Cholesterol, HDL; D014280:Triglycerides