[Splenectomy in hereditary hemolytic anemia: 82 Tunisian cases].
BACKGROUND
Splenectomy is frequently advised in hereditary hemolytic anemia. Severe complications could occur after splenectomy.


OBJECTIVE
To provide the indication and benefit of splenectomy


METHODS
clinical and biological patterns were performed in a retrospective study of 82 patients: 17 homozygous beta thalassemia, 17 thalassemia intermedia, 33 heterozygote Hb/S beta thalassemia and 15 hereditary spherocytosis.


RESULTS
Splenectomy was performed for: Hypertransfusion in homozygous thalassemia, hereditary spherocytosis; hypersplenism in Thalassemia intermedia and splenic sequestration in heterozygote HbS/beta thalassemia. The benefit of splenectomy was proved in hereditary spherocytosis (100%), heterozygote HbS/beta thalassemia (90%) and thalassemia intermedia (75%); nevertheless in homozygous beta thalassemia. Post splenectomical complication are often thrombocytosis, thrombosis and infections.


CONCLUSIONS
Splenectomy should be performed in hereditary hemolytic anemia to reduce and avoid transfusion.
Hafsia
Raouf
R
Service d'Hématologie biologique Hôpital Aziza Othmana, Tunis.
Zriba
Sami
S
Gouider
Emna
E
Ben Salah
Naouel
N
Borji
Wejdane
W
Zaouche
Abdejelil
A
D000293:Adolescent; D000328:Adult; D000745:Anemia, Hemolytic, Congenital / Q000601:surgery*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013156:Splenectomy; D014416:Tunisia; D055815:Young Adult