title: Foveal flicker sensitivity abnormalities in early glaucoma: associations with high blood pressure.
abstract: This study tested the hypothesis that (a) evidence of foveal visual dysfunction could be elicited in glaucoma subjects by measuring flicker sensitivity as a function of time after onset of an adapting field for a suitably chosen set of test and adaptation parameters and that (b) such dysfunction would be related to high blood pressure. Three groups of subjects were tested: (a) subjects with primary open-angle glaucoma but only minimal field loss, (b) normal control subjects, and (c) control subjects found to be suspect for glaucoma. The protocol included measurement of pulse rate and blood pressure, administration of Humphrey 30-2 visual fields and optic nerve head photography, and administration of a battery of psychophysical tests in Maxwellian view. This battery included a test of flicker sensitivity measured at middle wavelengths as a dynamic function of time after onset of a long-wavelength adapting field. The dynamic light-adaptation functions of subjects with glaucoma were much more likely to be unstable than were the corresponding functions of normal subjects. In addition, the dynamic light-adaptation functions of subjects with high blood pressure for their pulse rate were significantly less stable than the correspond ing functions of subjects without high blood pressure for their pulse rate. Moreover, the ratio of mean arterial pressure to pulse rate was significantly less for normal subjects than for either glaucoma subjects or for glaucoma-suspect subjects. We infer that among people with primary open-angle glau coma but with only minimal field loss, there often is foveal dysfunction associated with cardiovascular disease. Evidence of such dysfunction appears to require the use of stimulus conditions that tax the ability of the visual system to respond appropriately.
authors.affiliation: *Devers Eye Institute, dagger R. S. Dow Neurological Sciences Institute, and double daggerCasey Eye Institute, Portland, Oregon, U. S. A.
authors.forename: A
authors.initials: A
authors.lastname: Eisner
authors.forename: G A
authors.initials: GA
authors.lastname: Cioffi
authors.forename: H M
authors.initials: HM
authors.lastname: Campbell
authors.forename: J R
authors.initials: JR
authors.lastname: Samples