title: Novel lead for potent inhibitors of breast cancer resistance protein (BCRP).
abstract: From our modulator library an interesting inhibitor of breast cancer resistance protein (BCRP) was identified. Due to its high inhibitory potency, this compound may serve as a promising novel lead for the design of new and potent modulators. This adds a new structural class to the few known highly active BCRP inhibitors.
authors.affiliation: Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: Pick
authors.forename: Henrik
authors.initials: H
authors.lastname: Müller
authors.forename: Michael
authors.initials: M
authors.lastname: Wiese
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors* / Q000378:metabolism; D001549:Benzamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001562:Benzimidazoles / Q000378:metabolism; D045744:Cell Line, Tumor; D002734:Chlorophyll / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D008968:Molecular Conformation; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010671:Phenylurea Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D054852:Small Molecule Libraries
chemical_list: C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D001549:Benzamides; D001562:Benzimidazoles; D009363:Neoplasm Proteins; D010671:Phenylurea Compounds; D054852:Small Molecule Libraries; D002734:Chlorophyll; C032623:pheophorbide a; C017807:bisbenzimide ethoxide trihydrochloride