title: Inverse relationship between serum high density lipoprotein and negative syndrome in antipsychotic-naive schizophrenia.
abstract: BACKGROUND
  Recent literature suggests a role for apolipoprotein L (apoL) aberrations in the pathogenesis of schizophrenia. ApoL is almost exclusively associated with apolipoprotein A-I in high-density lipoproteins (HDLs). The objective of this study was to examine the correlation between symptom scores and serum HDL in antipsychotic-naive schizophrenia patients.
  
  
  METHODS
  In this cross-sectional study, 60 antipsychotic-naive schizophrenia patients were systematically examined for their symptom scores, with good inter-rater reliability. Concurrently, an overnight fasting serum lipid profile from these patients was assessed.
  
  
  RESULTS
  Serum HDL had a significant inverse correlation with a total negative syndrome score (rho=-0.43; p=0.001).
  
  
  CONCLUSIONS
  The study observation supports the potential role for HDL abnormalities in the genesis of negative symptoms in schizophrenia.
authors.affiliation: The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India. venkat.nimhans@yahoo.com
authors.forename: Ganesan
authors.initials: G
authors.lastname: Venkatasubramanian
authors.forename: Rashmi
authors.initials: R
authors.lastname: Arasappa
authors.forename: Naren P
authors.initials: NP
authors.lastname: Rao
authors.forename: Rishikesh V
authors.initials: RV
authors.lastname: Behere
authors.forename: Sunil
authors.initials: S
authors.lastname: Kalmady
authors.forename: Bangalore N
authors.initials: BN
authors.lastname: Gangadhar
mesh_terms: D000328:Adult; D000075944:Apolipoprotein L1; D001053:Apolipoproteins / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis
chemical_list: C108666:APOL1 protein, human; D000075944:Apolipoprotein L1; D001053:Apolipoproteins; D008075:Lipoproteins, HDL