Hymenopsins A and B and a macrophorin analogue from a fungicolous Hymenopsis sp.
Hymenopsin A (1), hymenopsin B (2), and a new macrophorin analogue, 2',3'-epoxy-13-hydroxy-4'-oxomacrophorin A (3), have been isolated from a fungicolous isolate of Hymenopsis sp. (MYC-1703; NRRL 37638). The structures and relative configurations of these compounds were assigned on the basis of 2D NMR and MS data, and the identity of 1 was confirmed by X-ray crystallographic analysis. The absolute configuration of 2 was proposed on the basis of CD analysis using both empirical and computational methods. Compounds 2 and 3 showed antibacterial activity against Staphylococcus aureus and Bacillus subtilis. Compound 3 was also active against Aspergillus flavus and Fusarium verticillioides.
Schmidt
Lori E
LE
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
Deyrup
Stephen T
ST
Baltrusaitis
Jonas
J
Swenson
Dale C
DC
Wicklow
Donald T
DT
Gloer
James B
JB
D001412:Bacillus subtilis / Q000187:drug effects; D018360:Crystallography, X-Ray; D005658:Fungi / Q000737:chemistry*; D006254:Hawaii; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
C438425:4'-oxomacrophorin A; D012717:Sesquiterpenes; C548919:hymenopsin A; C548920:hymenopsin B