title: Application of OMICS technologies in occupational and environmental health research; current status and projections.
abstract: OMICS technologies are relatively new biomarker discovery tools that can be applied to study large sets of biological molecules. Their application in human observational studies (HOS) has become feasible in recent years due to a spectacular increase in the sensitivity, resolution and throughput of OMICS-based assays. Although, the number of OMICS techniques is ever expanding, the five most developed OMICS technologies are genotyping, transcriptomics, epigenomics, proteomics and metabolomics. These techniques have been applied in HOS to various extents. However, their application in occupational environmental health (OEH) research has been limited. Here, we will discuss the opportunities these new techniques provide for OEH research. In addition we will address difficulties and limitations to the interpretation of the data that is generated by OMICS technologies. To illustrate the current status of the application of OMICS in OEH research, we will provide examples of studies that used OMICS technologies to investigate human health effects of two well-known toxicants, benzene and arsenic.
authors.affiliation: Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, University Utrecht, Po Box 80178, 3508 TD, Utrecht, the Netherlands. j.j.vlaanderen@uu.nl
authors.forename: J
authors.initials: J
authors.lastname: Vlaanderen
authors.forename: L E
authors.initials: LE
authors.lastname: Moore
authors.forename: M T
authors.initials: MT
authors.lastname: Smith
authors.forename: Q
authors.initials: Q
authors.lastname: Lan
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: C F
authors.initials: CF
authors.lastname: Skibola
authors.forename: N
authors.initials: N
authors.lastname: Rothman
authors.forename: R
authors.initials: R
authors.lastname: Vermeulen
mesh_terms: D001151:Arsenic / Q000633:toxicity; D001554:Benzene / Q000633:toxicity; D015415:Biomarkers / Q000378:metabolism; D019550:Environmental Medicine / Q000379:methods*; D020022:Genetic Predisposition to Disease; D023281:Genomics / Q000379:methods*; D006801:Humans; D009784:Occupational Diseases / Q000139:chemically induced / Q000235:genetics; D009787:Occupational Medicine / Q000379:methods*; D040901:Proteomics / Q000379:methods
chemical_list: D015415:Biomarkers; D001554:Benzene; D001151:Arsenic