title: Acellular dermal graft (AlloDerm) for upper eyelid reconstruction after cancer removal.
abstract: OBJECTIVE
  To report the use of AlloDerm for reconstruction of large upper eyelid defects in cancer patients.
  
  
  METHODS
  The clinical records of all patients who had AlloDerm as part of their upper eyelid reconstruction between July 2005 and July 2006 at a single institution were reviewed. Functional and cosmetic outcomes and postoperative complications were assessed.
  
  
  RESULTS
  Two patients had recurrent sebaceous gland carcinoma, 2 had melanoma, and 1 had squamous cell carcinoma. The upper eyelid defect involved the full thickness and entire width of the upper eyelid in 4 patients and full thickness and two thirds of the upper eye eyelid in 1 patient. The reconstructive procedure included a modified Cutler-Beard procedure using AlloDerm as the posterior lamellar sandwich graft in all 5 patients. One patient had early postoperative adjuvant radiation therapy to the upper eyelid. Three patients had excellent functional and cosmetic outcome; 2 patients had satisfactory outcomes. Two patients had residual exposure keratopathy. Allergic reaction to AlloDerm, infectious transmission, and immunologic rejection were not encountered at the time of this report (mean follow-up time = 13 months).
  
  
  CONCLUSIONS
  AlloDerm can be used as an alternative sandwich graft material to replace the tarsus for reconstruction of large upper eyelid defects using a modified Cutler-Beard procedure.
authors.affiliation: Section of Ophthalmology, Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
authors.forename: Brent
authors.initials: B
authors.lastname: Hayek
authors.forename: Elham
authors.initials: E
authors.lastname: Hatef
authors.forename: Michael
authors.initials: M
authors.lastname: Nguyen
authors.forename: Viet
authors.initials: V
authors.lastname: Ho
authors.forename: Adam
authors.initials: A
authors.lastname: Hsu
authors.forename: Bita
authors.initials: B
authors.lastname: Esmaeli
mesh_terms: D018266:Adenocarcinoma, Sebaceous / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D003094:Collagen / Q000627:therapeutic use*; D005142:Eyelid Neoplasms / Q000601:surgery*; D005143:Eyelids / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000601:surgery; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D017768:Skin, Artificial
chemical_list: C440568:Alloderm; D003094:Collagen