Controlled release and antitumor effect of pluronic F127 mixed with cisplatin in a rabbit model.
The purpose of this study was to evaluate pluronic F127 for the controlled release of cisplatin in a rabbit model. Pluronic F127 becomes liquid at temperatures <25 degrees C and converts to a gelatinous state at temperatures between 25 and 60 degrees C. Six Japanese white rabbits were injected with pluronic + cisplatin (n = 3, renal group A) or saline + cisplatin (n = 3, renal group B) to measure the platinum concentration in kidneys. Another 25 rabbits with VX2 liver tumors were divided into five equal groups. They were injected with saline, saline + cisplatin, iodized oil + cisplatin, pluronic alone, or pluronic + cisplatin and labeled as liver groups A, B, C, D, and E, respectively. The antitumor effect of pluronic was then assessed. In the presence of pluronic, the platinum concentration in the kidneys of rabbits remained relatively high. In animals with liver tumors, the delivery of pluronic + cisplatin produced higher tumor reduction rates (P < 0.05) than in the other groups, without apparent damage to normal liver tissue. We conclude that pluronic is useful for the controlled release of cisplatin in a rabbit model.
Sonoda
Akinaga
A
Department of Radiology, Shiga University of Medical Science, Shiga, Japan. akinagasonoda@yahoo.co.jp
Nitta
Norihisa
N
Ohta
Shinich
S
Nitta-Seko
Ayumi
A
Morikawa
Shigehiro
S
Tabata
Yasuhiko
Y
Takahashi
Masashi
M
Murata
Kiyoshi
K
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage* / Q000097:blood; D003692:Delayed-Action Preparations; D005079:Excipients / Q000008:administration & dosage; D007269:Injections, Intra-Arterial; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D020442:Poloxamer / Q000008:administration & dosage*; D011817:Rabbits
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D005079:Excipients; D020442:Poloxamer; D002945:Cisplatin