Detection of carbapenem resistance in clinical mucoid Pseudomonas aeruginosa isolates.
Of 19 isolates of mucoid Pseudomonas aeruginosa, 2 isolates showed imipenem resistance conferred by reduced OprD production. Imipenem resistance was detected by the MicroScan broth microdilution and Etest methods, but minimum inhibitory concentrations could not be determined by the Vitek system for an isolate. In cases where susceptibility cannot be determined by the broth microdilution methods, Etest results would be valuable for effective treatment.
Horii
Toshinobu
T
Department of Microbiology and Immunology, School of Medicine, Tottori University Faculty of Medicine, Yonago, Japan. horii@med.tottori-u.ac.jp
Adachi
Akiko
A
Morita
Motoki
M
D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism; D015780:Carbapenems / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D018272:Porins / Q000378:metabolism; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification / Q000378:metabolism
D001425:Bacterial Outer Membrane Proteins; D015780:Carbapenems; D018272:Porins; C077157:OprD protein, Pseudomonas aeruginosa