title: Systemic lidocaine decreased the perioperative opioid analgesic requirements but failed to reduce discharge time after ambulatory surgery.
abstract: BACKGROUND
  In this randomized, blinded, placebo-controlled trial, we evaluated whether systemic lidocaine would reduce pain and time to discharge in ambulatory surgery patients.
  
  
  METHODS
  Sixty-seven patients were enrolled to receive lidocaine or saline infusion perioperatively.
  
  
  RESULTS
  Length of postanesthesia care unit (PACU) stay did not differ between groups. Intraoperative opioid use was significantly less in the lidocaine group, both in the PACU and during the total study period but not after discharge. In the PACU, patients in the lidocaine group reported less pain (visual analog scale score 3.1 +/- 2.04 vs 4.5 +/- 2.9; P = 0.043). There were no differences in postoperative nausea and vomiting.
  
  
  CONCLUSIONS
  Perioperative systemic lidocaine significantly reduces opioid requirements in the ambulatory setting without affecting time to discharge.
authors.affiliation: Department of Anesthesia, University of Virginia, Charlottesville, VA 22908-0710, USA.
authors.forename: Allannah
authors.initials: A
authors.lastname: McKay
authors.forename: Antje
authors.initials: A
authors.lastname: Gottschalk
authors.forename: Annette
authors.initials: A
authors.lastname: Ploppa
authors.forename: Marcel E
authors.initials: ME
authors.lastname: Durieux
authors.forename: Danja S
authors.initials: DS
authors.lastname: Groves
mesh_terms: D000328:Adult; D000556:Ambulatory Surgical Procedures; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use*; D000762:Anesthesia Recovery Period; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007902:Length of Stay; D008012:Lidocaine / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D010351:Patient Discharge; D020250:Postoperative Nausea and Vomiting / Q000209:etiology; D013997:Time Factors
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D008012:Lidocaine