title: Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid.
abstract: The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS). Treatment was associated with low toxicity, but the KS clinical response and KS herpesvirus lytic induction rates were not sufficiently high to meet predefined criteria for efficacy.
authors.affiliation: Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
authors.forename: Maryjo
authors.initials: M
authors.lastname: Lechowicz
authors.forename: Dirk P
authors.initials: DP
authors.lastname: Dittmer
authors.forename: Jeannette Y
authors.initials: JY
authors.lastname: Lee
authors.forename: Susan E
authors.initials: SE
authors.lastname: Krown
authors.forename: William
authors.initials: W
authors.lastname: Wachsman
authors.forename: David
authors.initials: D
authors.lastname: Aboulafia
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Dezube
authors.forename: Lee
authors.initials: L
authors.lastname: Ratner
authors.forename: Jonathan
authors.initials: J
authors.lastname: Said
authors.forename: Richard F
authors.initials: RF
authors.lastname: Ambinder
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D005260:Female; D019288:Herpesvirus 8, Human / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis; D012514:Sarcoma, Kaposi / Q000188:drug therapy*; D014635:Valproic Acid / Q000627:therapeutic use*
chemical_list: D012367:RNA, Viral; D014635:Valproic Acid