Two self-management interventions to improve hypertension control: a randomized trial.
BACKGROUND
Fewer than 40% of persons with hypertension in the United States have adequate blood pressure (BP) control.


OBJECTIVE
To compare 2 self-management interventions for improving BP control among hypertensive patients.


METHODS
A 2 x 2 randomized trial, stratified by enrollment site and patient health literacy status, with 2-year follow-up. (ClinicalTrials.gov registration number: NCT00123058).


METHODS
2 university-affiliated primary care clinics.


METHODS
636 hypertensive patients.


METHODS
A centralized, blinded, and stratified randomization algorithm was used to randomly assign eligible patients to receive usual care, a behavioral intervention (bimonthly tailored, nurse-administered telephone intervention targeting hypertension-related behaviors), home BP monitoring 3 times weekly, or the behavioral intervention plus home BP monitoring.


METHODS
The primary outcome was BP control at 6-month intervals over 24 months.


RESULTS
475 patients (75%) completed the 24-month BP follow-up. At 24 months, improvements in the proportion of patients with BP control relative to the usual care group were 4.3% (95% CI, -4.5% to 12.9%) in the behavioral intervention group, 7.6% (CI, -1.9% to 17.0%) in the home BP monitoring group, and 11.0% (CI, 1.9%, 19.8%) in the combined intervention group. Relative to usual care, the 24-month difference in systolic BP was 0.6 mm Hg (CI, -2.2 to 3.4 mm Hg) for the behavioral intervention group, -0.6 mm Hg (CI, -3.6 to 2.3 mm Hg) for the BP monitoring group, and -3.9 mm Hg (CI, -6.9 to -0.9 mm Hg) for the combined intervention group; patterns were similar for diastolic BP.


CONCLUSIONS
Changes in medication use and diet were monitored only in intervention participants; 24-month outcome data were missing for 25% of participants, BP control was adequate at baseline in 73% of participants, and the study setting was an academic health center.


CONCLUSIONS
Combined home BP monitoring and tailored behavioral telephone intervention improved BP control, systolic BP, and diastolic BP at 24 months relative to usual care. .
Bosworth
Hayden B
HB
Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Center for Aging and Human Development, Duke Hypertension Center, and Duke Clinical Research Institute, Duke University, Durham, North Carolina 27703, USA. hayden.bosworth@duke.edu
Olsen
Maren K
MK
Grubber
Janet M
JM
Neary
Alice M
AM
Orr
Melinda M
MM
Powers
Benjamin J
BJ
Adams
Martha B
MB
Svetkey
Laura P
LP
Reed
Shelby D
SD
Li
Yanhong
Y
Dolor
Rowena J
RJ
Oddone
Eugene Z
EZ
D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001521:Behavior Therapy / Q000191:economics; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory / Q000191:economics; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000178:diet therapy / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009732:Nursing Care / Q000379:methods; D010349:Patient Compliance; D011897:Random Allocation; D013689:Telephone
D000959:Antihypertensive Agents