Clinical evaluation for lymphoproliferative disease prompted by finding of IgM warm autoanti-IT in two cases.
Anti-IT is an unusual specificity originally described as a naturally occurring cold agglutinin. The antibody reacts strongly with cord RBCs, weakly with adult I RBCs, and most weakly with the rare adult i RBCs. IgG anti-IT in patients with hemolytic anemia has been associated with Hodgkin's lymphoma. Difficulties in blood grouping tests and the presence of a warm reactive agglutinin in samples from two patients with hemolytic anemia led to further serologic studies and the identification of anti-IT. In both cases, the anti-IT was a rarely encountered IgM warm reactive agglutinin; in one case, the IgG component was also anti-IT, whereas in the second case the IgG antibody was broadly reactive. The unusual serologic finding of anti-IT prompted further clinical evaluation for lymphoproliferative disease in these two patients.
Leger
R M
RM
American Red Cross Blood Services, Southern California, Pomona, CA 91768, USA.
Lowder
F
F
Dungo
M C
MC
Chen
W
W
Mason
H M
HM
Garratty
G
G
D000741:Anemia, Aplastic / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000175:diagnosis* / Q000276:immunology* / Q000628:therapy; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D001213:Asian; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001803:Blood Transfusion; D003907:Dexamethasone / Q000627:therapeutic use; D004909:Erythrocyte Indices; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D007048:I Blood-Group System / Q000276:immunology*; D007075:Immunoglobulin M / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D019310:Pseudolymphoma / Q000097:blood / Q000175:diagnosis* / Q000276:immunology* / Q000628:therapy; D000069283:Rituximab; D014057:Tomography, X-Ray Computed; D055815:Young Adult
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D001323:Autoantibodies; D007048:I Blood-Group System; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D000069283:Rituximab; D003907:Dexamethasone