title: Pyrrolidinones from the ascomycete fungus Albonectria rigidiuscula.
abstract: The new pyrrolidinones, rigidiusculamides A-D (1-4), have been isolated from the crude extract of the ascomycete fungus Albonectria rigidiuscula. The structures of these compounds were elucidated primarily by NMR experiments. The absolute configuration of the 3,4-diol moieties in 1 and 4 was assigned using Snatzke's method. Compounds 1 and 2 showed modest cytotoxicity against the human tumor cell lines HeLa and MCF-7.
authors.affiliation: Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Shuchun
authors.initials: S
authors.lastname: Liu
authors.forename: Shubin
authors.initials: S
authors.lastname: Niu
authors.forename: Wenying
authors.initials: W
authors.lastname: Zhuang
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D002681:China; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011760:Pyrrolidinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014197:Trees / Q000382:microbiology
chemical_list: D000970:Antineoplastic Agents; D011760:Pyrrolidinones