Water-soluble porphyrin-polyethylene glycol conjugates with enhanced cellular uptake for photodynamic therapy.
Water soluble porphyrins were designed and prepared by Williamson ether synthesis reaction between tetrakis(p-bromomethylphenyl)porphyrin and polyethylene glycol (PEG) for photodynamic therapy. The quantum yields for the generation of singlet oxygen of tetra-polyethylene glycol branched porphyrin shows above 80% in D2O. Luminescence of singlet state oxygen was observed from D2O solution under the single-photon excitation at 514 nm. In vitro test, cellular uptake efficiency has been enhanced by simple modification of molecular structure through changing the number of PEG unit without any support such as polymer-encapsulated inorganic nanoparticles.
Kim
Won Jin
WJ
Department of Advanced Materials, Hannam University, Daejeon 305-701, Korea.
Kang
Min Soo
MS
Kim
Hwan Kyu
HK
Kim
Youngtak
Y
Chang
Taihyun
T
Ohulchanskyy
Tymish
T
Prasad
Paras N
PN
Lee
Kwang-Sup
KS
D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry* / Q000528:radiation effects; D006367:HeLa Cells; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000493:pharmacokinetics / Q000528:radiation effects / Q000627:therapeutic use; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000528:radiation effects; D011166:Porphyrins / Q000493:pharmacokinetics* / Q000528:radiation effects / Q000627:therapeutic use*; D012995:Solubility; D014867:Water / Q000737:chemistry*
D004337:Drug Carriers; D017319:Photosensitizing Agents; D011166:Porphyrins; D014867:Water; D011092:Polyethylene Glycols