Ugandenial A, a new drimane-type sesquiterpenoid from Warburgia ugandensis.
One new drimane-type sesquiterpenoid, named ugandenial A (1), was isolated from the ethyl acetate extract of the bark of Warburgia ugandensis (Canellaceae) together with eight known drimane-type sesquiterpenoids: 11alpha-hydroxycinnamosmolide (2), warburganal (3), polygodial (4), mukaadial (5), dendocarbin A (6), 9alpha-hydroxycinnamolide (7), dendocarbin L (8) and dendocarbin M (9). Their structures were established by detailed spectroscopic analysis. In addition a keto-enol equilibrium was demonstrated for compound 1 through a detailed NMR analysis run in CD(2)Cl(2) at 190 K. Cytotoxicity of the isolated compounds against KB cells was evaluated.
Xu
Min
M
Kunming Institute of Botany, Chinese Academy of Sciences, Heilongtan, Kunming 650204, China. xumin@mail.kib.ac.cn
Litaudon
Marc
M
Krief
Sabrina
S
Martin
Marie-Thérèse
MT
Kasenene
John
J
Kiremire
Bernard
B
Dumontet
Vincent
V
Guéritte
Françoise
F
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D029624:Ferns / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D024301:Plant Bark / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000970:Antineoplastic Agents; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane; C546515:ugandenial A