Angiotensinogen polymorphisms and acquired atrial fibrillation in Chinese.
Genetic predisposition may be underlying the prevalence of acquired atrial fibrillation (AF). We investigated the association between polymorphism in angiotensinogen (AGT) and angiotensin-converting enzyme gene and risk of acquired AF in a pair-matched case-control study conducted in Chinese Hans. We selected 9 single nucleotide polymorphisms (SNPs) in the AGT gene and 3 SNPs in the angiotensin-converting enzyme gene using a tagging-SNP strategy. We observed significant association between tagging-SNP rs699 (M235T), located in exon 2 of the AGT gene, and AF. The AA genotype of rs699 increased the risk of AF by 70% (95% confidence interval, 1.01-2.85; P = .044) under a recessive model (AA vs AG + GG). The significance remained after controlling for covariates age, smoking, body mass index, hypertension, diabetes, and left atrial dimension, with an increased risk of AF by 90% (95% confidence interval, 1.04-3.46; P = .036). We provide evidence that polymorphism in AGT gene may confer predisposition to acquired atrial fibrillation in Chinese Hans.
Wang
Qun-Shan
QS
Department of Cardiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Li
Yi-Gang
YG
Chen
Xing-Dong
XD
Yu
Jie-Fei
JF
Wang
Jun
J
Sun
Jian
J
Lu
Shang-Biao
SB
Jin
Li
L
Wang
Xiao-Feng
XF
D000368:Aged; D000808:Angiotensinogen / Q000235:genetics*; D001281:Atrial Fibrillation / Q000453:epidemiology* / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D012083:Renin / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors
D000808:Angiotensinogen; D012083:Renin