title: A multi-trial diagnostic tool in fin whale (Balaenoptera physalus) skin biopsies of the Pelagos Sanctuary (Mediterranean Sea) and the Gulf of California (Mexico).
abstract: The main objective of this study was to apply a set of sensitive non-lethal biomarkers in skin biopsies of fin whales (Balaenoptera physalus) to evaluate the toxicological status of this mysticete in the Pelagos Sanctuary (Mediterranean Sea) and in the Gulf of California (Sea of Cortez-Mexico). We developed a "multi-trial diagnostic tool" (based on field and in vitro studies), combining molecular biomarkers (western blot of CYP1A1, CYP2B) and gene expression (qRT-PCR of HSP70, ERα, AHR, E2F-1) with the analysis of OCs, PAHs and PBDEs. The study revealed a higher level of toxicological stress in the Mediterranean fin whales.
authors.affiliation: Department of Environmental Sciences, University of Siena, Via Mattioli 4, Siena, Italy. Fossi@unisi.it
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Fossi
authors.forename: Jorge
authors.initials: J
authors.lastname: Urban
authors.forename: Silvia
authors.initials: S
authors.lastname: Casini
authors.forename: Silvia
authors.initials: S
authors.lastname: Maltese
authors.forename: Giacomo
authors.initials: G
authors.lastname: Spinsanti
authors.forename: Cristina
authors.initials: C
authors.lastname: Panti
authors.forename: Serena
authors.initials: S
authors.lastname: Porcelloni
authors.forename: Simone
authors.initials: S
authors.lastname: Panigada
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Lauriano
authors.forename: Carlos
authors.initials: C
authors.lastname: Niño-Torres
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Rojas-Bracho
authors.forename: Begoña
authors.initials: B
authors.lastname: Jimenez
authors.forename: Juan
authors.initials: J
authors.lastname: Muñoz-Arnanz
authors.forename: Letizia
authors.initials: L
authors.lastname: Marsili
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D001706:Biopsy / Q000379:methods / Q000662:veterinary; D015153:Blotting, Western; D004784:Environmental Monitoring; D005260:Female; D050617:Fin Whale; D020869:Gene Expression Profiling; D008297:Male; D008522:Mediterranean Sea; D008800:Mexico; D012867:Skin; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D015415:Biomarkers; D014874:Water Pollutants, Chemical