A review of long-term prophylaxis in the rare inherited coagulation factor deficiencies.
The rare inherited coagulation factor deficiencies (deficiencies of factors I, II, V, VII, XI, XIII, combined FV + FVII deficiency, combined deficiency of the vitamin K dependent factors and von Willebrand disease type 3) have an aggregate prevalence of approximately 1:100,000. They may cause recurrent life or function threatening haemorrhage. In this article we review the available literature on long-term prophylaxis and, where possible, make recommendations on this important area.
Todd
T
T
Department of Haematology, Royal Devon and Exeter Hospital, Exeter, UK. anthony.todd@rdeft.nhs.uk
Perry
D J
DJ
D001778:Blood Coagulation Disorders / Q000188:drug therapy*; D001779:Blood Coagulation Factors / Q000008:administration & dosage / Q000627:therapeutic use*; D005340:Fibrinogen; D006801:Humans; D014813:Vitamin K Deficiency / Q000188:drug therapy
D001779:Blood Coagulation Factors; D005340:Fibrinogen