Interactions with GluR1 AMPA receptors could influence the therapeutic usefulness of minocycline in ALS.
Despite the beneficial effects of minocycline seen in animal models of ALS, initial clinical trials of minocycline in ALS patients failed to support its expected therapeutic usefulness. Here we discuss new results from recent preclinical studies of the molecular neuronal effects of minocycline pertinent for better understanding of the therapeutic potential of this antibiotic.
Manev
Hari
H
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, Illinois 60612, USA. Hmanev@psych.uic.edu
Manev
Radmila
R
D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006801:Humans; D008911:Minocycline / Q000627:therapeutic use*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018091:Receptors, AMPA / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D008911:Minocycline; D018091:Receptors, AMPA