title: Ugandenial A, a new drimane-type sesquiterpenoid from Warburgia ugandensis.
abstract: One new drimane-type sesquiterpenoid, named ugandenial A (1), was isolated from the ethyl acetate extract of the bark of Warburgia ugandensis (Canellaceae) together with eight known drimane-type sesquiterpenoids: 11alpha-hydroxycinnamosmolide (2), warburganal (3), polygodial (4), mukaadial (5), dendocarbin A (6), 9alpha-hydroxycinnamolide (7), dendocarbin L (8) and dendocarbin M (9). Their structures were established by detailed spectroscopic analysis. In addition a keto-enol equilibrium was demonstrated for compound 1 through a detailed NMR analysis run in CD(2)Cl(2) at 190 K. Cytotoxicity of the isolated compounds against KB cells was evaluated.
authors.affiliation: Kunming Institute of Botany, Chinese Academy of Sciences, Heilongtan, Kunming 650204, China. xumin@mail.kib.ac.cn
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Sabrina
authors.initials: S
authors.lastname: Krief
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Martin
authors.forename: John
authors.initials: J
authors.lastname: Kasenene
authors.forename: Bernard
authors.initials: B
authors.lastname: Kiremire
authors.forename: Vincent
authors.initials: V
authors.lastname: Dumontet
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D029624:Ferns / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D024301:Plant Bark / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane; C546515:ugandenial A