Neuropeptide Y polymorphisms and ischemic stroke in Chinese population.
BACKGROUND
Stroke is the second most common cause of death in developed countries and a major cause of adult disability and mortality worldwide. New data strongly suggest that neuropeptide Y (NPY) may be a candidate gene for ischemic stroke.


METHODS
We investigated 450 ischemic stroke patients and 423 healthy controls matched for sex and age in a Han Chinese population. Three functional polymorphisms (-883TGins/del, -602G/T and -399 T/C) located in NPY gene promoter were genotyped using DNA sequencing methods.


RESULTS
Of 3 NPY polymorphisms investigated in our study, the -399CC genotype (OR: 1.699, 95% CI: 1.124-2.567, P=0.011) and the -399C allele (OR: 1.254, 95% CI: 1.031-1.524, P=0.023) were more frequent among ischemic stroke patients than in controls, especially in the small vessel disease (SVD) subtype patients. The similar results were observed in multivariable logistic regression analysis. Haplotype analysis revealed that the -883ins/-399C haplotype was a risk marker for ischemic stroke (P=0.008).


CONCLUSIONS
The C allele of -399 T/C polymorphism in the promoter regions of NPY is an independent risk factor for ischemic stroke, suggesting that NYP system may involve in the mechanisms of stroke pathology.
Yu
Jin-Tai
JT
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province 266071, PR China.
Yu
Nan-Nan
NN
Gao
Si-Shan
SS
Song
Jing-Hui
JH
Ma
Teng
T
Wang
Nai-Dong
ND
Tang
Yong-Chun
YC
Zhang
Na
N
Tan
Lan
L
D000368:Aged; D044466:Asian People / Q000235:genetics*; D002545:Brain Ischemia / Q000150:complications* / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D008297:Male; D009478:Neuropeptide Y / Q000235:genetics*; D011110:Polymorphism, Genetic; D020521:Stroke / Q000150:complications* / Q000235:genetics*
D009478:Neuropeptide Y