title: Chiral 1,2-diols: the assignment of their absolute configuration by NMR made easy.
abstract: The absolute configuration of a 1,2-primary/secondary diol can be easily determined by preparation of its bis-(R)- and bis-(S)-9-AMA ester derivatives, followed by comparison of the NMR chemical shifts of the diastereotopic methylene protons in the two derivatives. Alternatively, the assignment can be carried out using only one derivative if the evolution with temperature of the signals corresponding to the CalphaH protons is analyzed.
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, and Unidad de RMN de Biomoléculas Asociada al CSIC, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
authors.forename: Félix
authors.initials: F
authors.lastname: Freire
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Seco
authors.forename: Emilio
authors.initials: E
authors.lastname: Quiñoá
authors.forename: Ricardo
authors.initials: R
authors.lastname: Riguera
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012015:Reference Standards; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D004952:Esters