[Cardioprotective and lipid-regulating effects of etoxidol with respect to surgical endotoxinemia].
Chronic experiments on stray dogs with modeling peritonitis showed that a complex therapy involving etoxidol favors improvement of the electrophysiological and metabolic heart activity and provides correction of the lipid distress syndrome. It is established that the lipid regulating effect of etoxidol is related not only to a decrease in the intensity of lipid peroxidation (LPO), but also to the A2-phospholipasae activity of this drug.
Vlasov
A P
AP
Nachkina
E A
EA
Grigor'eva
T I
TI
Leshchankina
N Iu
NIu
Vlasova
V P
VP
D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D004285:Dogs; D019446:Endotoxemia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010538:Peritonitis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D054467:Phospholipases A2 / Q000378:metabolism*; D011725:Pyridines / Q000494:pharmacology*
C457919:3-oxypyridine; D002316:Cardiotonic Agents; D011725:Pyridines; D054467:Phospholipases A2