title: Arc1p: anchoring, routing, coordinating.
abstract: Accurate synthesis of aminoacyl-tRNAs (aa-tRNA) by aminoacyl-tRNA synthetases (aaRS) is an absolute requirement for errorless decoding of the genetic code and is studied since more than four decades. In all three kingdoms of life aaRSs are capable of assembling into multi-enzymatic complexes that are held together by auxiliary non-enzymatic factors, but the role of such macromolecular assemblies is still poorly understood. In the yeast Saccharomyces cerevisiae, Arc1p holds cytosolic methionyl-tRNA synthetase ((c)MRS) and glutamyl-tRNA synthetase ((c)ERS) together and plays an important role in fine tuning several cellular processes like aminoacylation, translation and carbon source adaptation.
authors.affiliation: UPR 9002 'Architecture et Réactivité de l'ARN', Université de Strasbourg, CNRS, Institut de Biologie Moléculaire et Cellulaire, 15 Rue René Descartes, F-67084 Strasbourg Cedex, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Frechin
authors.forename: Daniel
authors.initials: D
authors.lastname: Kern
authors.forename: Robert Pierre
authors.initials: RP
authors.lastname: Martin
authors.forename: Hubert Dominique
authors.initials: HD
authors.lastname: Becker
authors.forename: Bruno
authors.initials: B
authors.lastname: Senger
mesh_terms: D003067:Coenzymes / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D005975:Glutamate-tRNA Ligase / Q000378:metabolism*; D012343:RNA, Transfer / Q000378:metabolism*; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D046249:Transfer RNA Aminoacylation
chemical_list: C102145:ARC1 protein, S cerevisiae; D003067:Coenzymes; D012346:RNA, Transfer, Amino Acyl; D016601:RNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins; C026464:tRNA(m)(Met), methionine-; D012343:RNA, Transfer; D005975:Glutamate-tRNA Ligase