title: Fruits and vegetables consumption and the risk of histological  subtypes of lung cancer in the European Prospective Investigation  into Cancer and Nutrition (EPIC).
abstract: OBJECTIVE
  To examine the association between fruit and vegetable consumption and risk of different histological subtypes of lung cancer among participants of the European Prospective Investigation into Cancer and Nutrition study.
  
  
  METHODS
  Multivariable Cox proportional hazard models were used to analyze the data. A calibration study in a subsample was used to reduce dietary measurement errors.
  
  
  RESULTS
  During a mean follow-up of 8.7 years, 1,830 incident cases of lung cancer (574 adenocarcinoma, 286 small cell, 137 large cell, 363 squamous cell, 470 other histologies) were identified. In line with our previous conclusions, we found that after calibration a 100 g/day increase in fruit and vegetables consumption was associated with a reduced lung cancer risk (HR 0.94; 95% CI 0.89-0.99). This was also seen among current smokers (HR 0.93; 95% CI 0.90-0.97). Risks of squamous cell carcinomas in current smokers were reduced for an increase of 100 g/day of fruit and vegetables combined (HR 0.85; 95% CI 0.76-0.94), while no clear effects were seen for the other histological subtypes.
  
  
  CONCLUSIONS
  We observed inverse associations between the consumption of vegetables and fruits and risk of lung cancer without a clear effect on specific histological subtypes of lung cancer. In current smokers, consumption of vegetables and fruits may reduce lung cancer risk, in particular the risk of squamous cell carcinomas.
authors.affiliation: National Institute of Public Health and the Environment, Bilthoven, The Netherlands. frederike.buchner@rivm.nl
authors.forename: F L
authors.initials: FL
authors.lastname: Büchner
authors.forename: H B
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: J
authors.initials: J
authors.lastname: Linseisen
authors.forename: H C
authors.initials: HC
authors.lastname: Boshuizen
authors.forename: L A L M
authors.initials: LA
authors.lastname: Kiemeney
authors.forename: M M
authors.initials: MM
authors.lastname: Ros
authors.forename: K
authors.initials: K
authors.lastname: Overvad
authors.forename: L
authors.initials: L
authors.lastname: Hansen
authors.forename: A
authors.initials: A
authors.lastname: Tjonneland
authors.forename: O
authors.initials: O
authors.lastname: Raaschou-Nielsen
authors.forename: F
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: M-C
authors.initials: MC
authors.lastname: Boutron-Ruault
authors.forename: M
authors.initials: M
authors.lastname: Touillaud
authors.forename: R
authors.initials: R
authors.lastname: Kaaks
authors.forename: S
authors.initials: S
authors.lastname: Rohrmann
authors.forename: H
authors.initials: H
authors.lastname: Boeing
authors.forename: U
authors.initials: U
authors.lastname: Nöthlings
authors.forename: A
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: D
authors.initials: D
authors.lastname: Zylis
authors.forename: V
authors.initials: V
authors.lastname: Dilis
authors.forename: D
authors.initials: D
authors.lastname: Palli
authors.forename: S
authors.initials: S
authors.lastname: Sieri
authors.forename: P
authors.initials: P
authors.lastname: Vineis
authors.forename: R
authors.initials: R
authors.lastname: Tumino
authors.forename: S
authors.initials: S
authors.lastname: Panico
authors.forename: P H M
authors.initials: PH
authors.lastname: Peeters
authors.forename: C H
authors.initials: CH
authors.lastname: van Gils
authors.forename: E
authors.initials: E
authors.lastname: Lund
authors.forename: I T
authors.initials: IT
authors.lastname: Gram
authors.forename: T
authors.initials: T
authors.lastname: Braaten
authors.forename: C
authors.initials: C
authors.lastname: Martinez
authors.forename: A
authors.initials: A
authors.lastname: Agudo
authors.forename: L
authors.initials: L
authors.lastname: Arriola
authors.forename: E
authors.initials: E
authors.lastname: Ardanaz
authors.forename: C
authors.initials: C
authors.lastname: Navarro
authors.forename: L
authors.initials: L
authors.lastname: Rodríguez
authors.forename: J
authors.initials: J
authors.lastname: Manjer
authors.forename: E
authors.initials: E
authors.lastname: Wirfält
authors.forename: G
authors.initials: G
authors.lastname: Hallmans
authors.forename: T
authors.initials: T
authors.lastname: Rasmuson
authors.forename: T J
authors.initials: TJ
authors.lastname: Key
authors.forename: A W
authors.initials: AW
authors.lastname: Roddam
authors.forename: S
authors.initials: S
authors.lastname: Bingham
authors.forename: K-T
authors.initials: KT
authors.lastname: Khaw
authors.forename: N
authors.initials: N
authors.lastname: Slimani
authors.forename: P
authors.initials: P
authors.lastname: Bofetta
authors.forename: G
authors.initials: G
authors.lastname: Byrnes
authors.forename: T
authors.initials: T
authors.lastname: Norat
authors.forename: D
authors.initials: D
authors.lastname: Michaud
authors.forename: E
authors.initials: E
authors.lastname: Riboli
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000517:prevention & control*; D000328:Adult; D000975:Antioxidants; D002289:Carcinoma, Non-Small-Cell Lung / Q000453:epidemiology / Q000517:prevention & control*; D018288:Carcinoma, Small Cell / Q000453:epidemiology / Q000517:prevention & control*; D005060:Europe / Q000453:epidemiology; D005260:Female; D005638:Fruit; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012107:Research Design; D012907:Smoking / Q000453:epidemiology; D014675:Vegetables; D055815:Young Adult
chemical_list: D000975:Antioxidants