A concise route to the proposed structure of lydiamycin B, an antimycobacterial depsipeptide.
The total synthesis of four possible isomers with the proposed structure of antimycobacterial depsipeptide lydiamycin B is achieved. None of them shows identical NMR data with those reported for natural lydiamycin B, indicating that further structural revisions are required.
Li
Wenhua
W
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
Gan
Jiangang
J
Ma
Dawei
D
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D047630:Depsipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry
D000900:Anti-Bacterial Agents; D047630:Depsipeptides; C521011:lydiamycin B