title: Role of ADP-ribosyl cyclase in the pathogenesis of neurological disorders after coronary artery bypass surgery and experimental ischemia.
abstract: The pathogenesis of neuronal dysfunction was evaluated from the viewpoint of cellular disturbances in NAD(+) metabolism and changes in activity of NAD(+)-utilizing enzymes (e.g., ADP-ribosyl cyclase/CD38). S-100B concentration and CD38 expression on peripheral blood lymphocytes were altered in patients after surgery for coronary heart disease with extracorporeal circulation. These changes in patients during the early postoperative period correlated with variations in CD38 expression on neuronal cells from postischemic rats with cognitive dysfunction.
authors.affiliation: Institute of General Resuscitation, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Moroz
authors.forename: A B
authors.initials: AB
authors.lastname: Salmina
authors.forename: A A
authors.initials: AA
authors.lastname: Fursov
authors.forename: S V
authors.initials: SV
authors.lastname: Mikhutkina
authors.forename: K Y
authors.initials: KY
authors.lastname: Linev
authors.forename: N S
authors.initials: NS
authors.lastname: Mantorova
authors.forename: S V
authors.initials: SV
authors.lastname: Shakhmaeva
mesh_terms: D036541:ADP-ribosyl Cyclase / Q000378:metabolism / Q000502:physiology*; D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000166:cytology; D001026:Coronary Artery Bypass; D006801:Humans; D007118:Immunoassay; D007511:Ischemia / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D009243:NAD / Q000378:metabolism; D009414:Nerve Growth Factors / Q000378:metabolism; D009474:Neurons / Q000201:enzymology* / Q000473:pathology; D011184:Postoperative Period; D051381:Rats; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000378:metabolism
chemical_list: D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D009243:NAD; D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1