title: Surveillance of transmitted resistance to antiretroviral drug classes among young children in the Western Cape Province of South Africa.
abstract: There are limited data on transmitted antiretroviral resistance in young children who require antiretroviral therapy. We adapted the World Health Organization surveillance strategy, testing antiretroviral naive infants (<18 months) in the Western Cape Province of South Africa, and detecting only 3 non-nucleoside reverse transcriptase inhibitors (NNRTI) and no NRTI or protease inhibitor surveillance mutations in 49 patients. The estimated NRTI and protease inhibitor transmitted antiretroviral resistance prevalence is low (<5%), predicting good therapeutic response in Western Cape infants.
authors.affiliation: Division of Medical Virology, Stellenbosch University, Tygerberg, South Africa. guvz@sun.ac.za.
authors.forename: Gert U
authors.initials: GU
authors.lastname: van Zyl
authors.forename: Mark F
authors.initials: MF
authors.lastname: Cotton
authors.forename: Mathilda
authors.initials: M
authors.lastname: Claassen
authors.forename: Charmaine
authors.initials: C
authors.lastname: Abrahams
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Preiser
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral / Q000235:genetics*; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D006801:Humans; D007223:Infant; D009154:Mutation; D011159:Population Surveillance / Q000379:methods; D015995:Prevalence; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*; D013019:South Africa / Q000453:epidemiology; D014944:World Health Organization
chemical_list: D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors