title: Synthesis of some new S-triazine based chalcones and their derivatives as potent antimicrobial agents.
abstract: Base catalysed condensation of ketone 5 with different aldehydes give chalcones, 2.4-bis-(phenylamino)-6-[4'-{3''-(4'''-substituted phenyl/2'''-furanyl/2'''-thienyl)-2''-propenon-1''-yl}phenylamino]-s-thriazines 6a-e. These chalcones on cyclization with hydrazine hydrate in the presence of glacial acetic acid, guanidine nitrate in the presence of alkali and malononitrile in the presence of ammonium acetate give the corresponding acetylpyrazolines 7a-e, aminopyrimidines 8a-e and cyanopyridines 9a-e respectively. The products 6a-e, 7a-e, 8a-e and 9a-e were fully characterized by spectroscopic and elemental analysis and also tested for antibacterial activity.
authors.affiliation: Department of Chemistry, B.K.M.Science College, Valsad 396001, India. dranjani_solankee@yahoo.com
authors.forename: Anjani
authors.initials: A
authors.lastname: Solankee
authors.forename: Kishor
authors.initials: K
authors.lastname: Kapadia
authors.lastname: Ana Cirić
authors.forename: Marina
authors.initials: M
authors.lastname: Soković
authors.forename: Irini
authors.initials: I
authors.lastname: Doytchinova
authors.forename: Athina
authors.initials: A
authors.lastname: Geronikaki
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002599:Chalcone / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry; D021281:Quantitative Structure-Activity Relationship; D013816:Thermodynamics; D014227:Triazines / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D011720:Pyrazoles; D011725:Pyridines; D011743:Pyrimidines; D014227:Triazines; C031280:pyrazole; D002599:Chalcone; C030986:pyrimidine; C023666:pyridine