title: Transfusion-related acute lung injury (TRALI) induced by donor-derived anti-HLA antibodies in aplastic anemia: possible priming effect of granulocyte-colony stimulating factor (G-CSF) on the recipient neutrophils.
abstract: Transfusion-related acute lung injury (TRALI) is currently the leading cause of transfusion-related death. A 67-year-old man with severe aplastic anemia developed TRALI, consisting of acute respiratory insufficiency with severe hypoxia and diffuse pulmonary infiltration 2 hours after the transfusion of platelet concentrates. Although he required intensive respiratory support, he promptly recovered within 4 days. The presence of anti-HLA antibody (anti-HLA B52) in the donated blood product was demonstrated, and a lymphocytotoxicity test disclosed antibody-mediated cytotoxicity against the patient's cells. Furthermore, administration of granulocyte-colony stimulating factor was suggested to predispose the patient to TRALI by priming the neutrophils.
authors.affiliation: Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto.
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Hishizawa
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Mitsuhashi
authors.forename: Tatsuharu
authors.initials: T
authors.lastname: Ohno
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology* / Q000276:immunology; D000368:Aged; D000741:Anemia, Aplastic / Q000276:immunology / Q000628:therapy*; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects / Q000276:immunology*; D015235:HLA-B Antigens / Q000097:blood / Q000276:immunology*; D059950:HLA-B52 Antigen; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology*; D065227:Transfusion Reaction
chemical_list: D015235:HLA-B Antigens; D059950:HLA-B52 Antigen; D007518:Isoantibodies; D016179:Granulocyte Colony-Stimulating Factor