title: Parietal analgesia decreases postoperative diaphragm dysfunction induced by abdominal surgery: a physiologic study.
abstract: OBJECTIVE
  The postoperative analgesic strategy may influence the magnitude of the postoperative diaphragmatic dysfunction (PODD) induced by abdominal surgery. The purpose of this physiologic study was to evaluate the effect of continuous preperitoneal wound infusion (CPWI) of ropivacaine on PODD after open colorectal surgery.
  
  
  METHODS
  Twenty patients with American Society of Anesthesiologists physical status I or II undergoing open colorectal surgery were prospectively included during 2 consecutive 2-month periods. During the first period, we evaluated 10 consecutive patients who received conventional parenteral analgesia (intravenously administered morphine via patient-controlled analgesia and acetaminophen) without parietal analgesia (control group). These patients were compared with 10 consecutive patients who received conventional parenteral analgesia along with parietal analgesia using CPWI of 0.2% ropivacaine at 10 mL/hr for 48 hrs (CPWI group). Diaphragmatic function was assessed preoperatively and at 24 and 48 hrs postoperatively using the sniff nasal inspiratory pressure test (Psniff). Supplemental intravenously administered morphine boluses were administered as needed before Psniff assessments in the control group to reduce differences in pain intensity.
  
  
  RESULTS
  Demographic and surgical data did not differ between the 2 groups, nor did preoperative Psniff values (71 cm H2O [SD, 20 cm H2O] vs 65 cm H2O [SD,15 cm H2O] in the control and CPWI groups, respectively). Postoperative Psniff was significantly decreased in the 2 groups, but the reduction was significantly greater in the control group than in the CPWI group both at 24 hrs (-58% [SD, 18%] vs -24% [SD, 19%]; P = 0.001) and at 48 hrs (-44% [SD, 31%] vs -11% [SD, 32%]; P = 0.027).
  
  
  CONCLUSIONS
  Parietal analgesia delivered via a CPWI of ropivacaine reduces PODD induced by open colorectal surgery.
authors.affiliation: Department of Anesthesia and Intensive Care, St-Antoine Hospital, APHP Université Pierre et Marie Curie, Paris, France. marc.beaussier@sat.aphp.fr
authors.forename: Marc
authors.initials: M
authors.lastname: Beaussier
authors.forename: Hanna
authors.initials: H
authors.lastname: El'ayoubi
authors.forename: Maxime
authors.initials: M
authors.lastname: Rollin
authors.forename: Yann
authors.initials: Y
authors.lastname: Parc
authors.forename: Arthur
authors.initials: A
authors.lastname: Atchabahian
authors.forename: Gerald
authors.initials: G
authors.lastname: Chanques
authors.forename: Xavier
authors.initials: X
authors.lastname: Capdevila
authors.forename: André
authors.initials: A
authors.lastname: Lienhart
authors.forename: Samir
authors.initials: S
authors.lastname: Jaber
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage; D000328:Adult; D000368:Aged; D000577:Amides / Q000008:administration & dosage*; D000698:Analgesia / Q000379:methods*; D016058:Analgesia, Patient-Controlled; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000779:Anesthetics, Local / Q000008:administration & dosage*; D003106:Colon / Q000601:surgery*; D003964:Diaphragm / Q000187:drug effects* / Q000503:physiopathology; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D001239:Inhalation / Q000187:drug effects; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage; D010147:Pain Measurement; D010149:Postoperative Pain / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D012007:Rectum / Q000601:surgery*; D000077212:Ropivacaine
chemical_list: D000577:Amides; D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D000082:Acetaminophen; D009020:Morphine; D000077212:Ropivacaine