title: Adiponectin is independently associated with apolipoprotein B to A-1 ratio in Koreans.
abstract: Apolipoprotein B to A-1 (apo B/A-1) ratio is reportedly a better predictor of atherosclerotic vascular disease than low-density lipoprotein cholesterol (LDL-C). The aim of this study was to assess the association of serum apo B/A-1 ratio with insulin resistance and adiponectin in patients with different grades of glucose intolerance. Patients were divided according to glucose tolerance into 3 groups: normal glucose tolerance without metabolic syndrome (n = 229), impaired fasting glucose (subjects with fasting plasma glucose level between 100 and 125 mg/dL, n = 658), and type 2 diabetes mellitus (n = 381). Serum concentrations of apo B, apo A-1, glucose, total cholesterol (TC), triglycerides, and high-density lipoprotein cholesterol (HDL-C) and adiponectin were measured. Insulin resistance was estimated by the homeostasis model assessment of insulin resistance index (HOMA-IR). There were significant differences in metabolic parameters among the groups, including waist circumference, insulin, HOMA-IR, and apo B/A-1 ratio, which increased sequentially with glucose intolerance, whereas adiponectin level decreased with increasing severity of glucose intolerance. The apo B/A-1 ratio was significantly correlated with TC, triglycerides, LDL-C, HDL-C, adiponectin, and HOMA-IR in normal glucose tolerance, impaired fasting glucose, and type 2 diabetes mellitus. Multiple regression analysis showed that apo B/A-1 ratio was significantly associated with TC, LDL-C, HDL-C, and adiponectin. In conclusion, apo B/A-1 ratio was significantly associated with insulin resistance according to glucose intolerance; and serum adiponectin was an important independent factor associated with apo B/A-1 ratio in Koreans.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Jong Suk
authors.initials: JS
authors.lastname: Park
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Cho
authors.forename: Ji Sun
authors.initials: JS
authors.lastname: Nam
authors.forename: Jeong Seon
authors.initials: JS
authors.lastname: Yoo
authors.forename: Yoon Bum
authors.initials: YB
authors.lastname: Lee
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Roh
authors.forename: Chul Woo
authors.initials: CW
authors.lastname: Ahn
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Jee
authors.forename: Bong Soo
authors.initials: BS
authors.lastname: Cha
authors.forename: Eun Jig
authors.initials: EJ
authors.lastname: Lee
authors.forename: Sung Kil
authors.initials: SK
authors.lastname: Lim
authors.forename: Kyung Rae
authors.initials: KR
authors.lastname: Kim
authors.forename: Hyun Chul
authors.initials: HC
authors.lastname: Lee
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D018149:Glucose Intolerance; D006801:Humans; D007333:Insulin Resistance; D007723:Korea; D016014:Linear Models; D008875:Middle Aged; D015999:Multivariate Analysis; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D014280:Triglycerides; D002784:Cholesterol