title: Substituted tetrahydro-beta-carbolines as potential agents for the treatment of human papillomavirus infection.
abstract: The identification and optimization of a series of substituted tetrahydro-beta-carbolines with potent activity against human papillomavirus is described. Structure-activity studies focused on the substitution pattern and chirality of the beta-carboline ring system are discussed. Optimization of these parameters led to compounds with antiviral activities in the low nanomolar range.
authors.affiliation: Department of Medicinal Chemistry, Infectious Diseases Center for Excellence in Drug Discovery, GlaxoSmithKline Research and Development, Five Moore Drive, Research Triangle Park, NC 27709-3398, USA. john.6.miller@gsk.com
authors.forename: John F
authors.initials: JF
authors.lastname: Miller
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Turner
authors.forename: Ronald G
authors.initials: RG
authors.lastname: Sherrill
authors.forename: Kristjan
authors.initials: K
authors.lastname: Gudmundsson
authors.forename: Andrew
authors.initials: A
authors.lastname: Spaltenstein
authors.forename: Phiroze
authors.initials: P
authors.lastname: Sethna
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Brown
authors.forename: Robert
authors.initials: R
authors.lastname: Harvey
authors.forename: Karen R
authors.initials: KR
authors.lastname: Romines
authors.forename: Pamela
authors.initials: P
authors.lastname: Golden
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D002460:Cell Line; D006801:Humans; D051379:Mice; D030361:Papillomavirus Infections / Q000188:drug therapy; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D002243:Carbolines