title: [Clinical significance of plasma N-terminal pro- B-type natriuretic peptide in respiratory distress syndrome of the preterm neonate].
abstract: BACKGROUND
  Plasma brain-type natriuretic peptide (BNP) is secreted by cardiac myocytes in response to pressure or volume overload. Recently, an assay to measure the N-terminal segment of the pro-hormone (NT-pro-BNP) was developed.
  
  
  OBJECTIVE
  (1) To determine the plasma levels of NT-pro-BNP in premature neonates without congenital heart disease; (2) to determine the relationship between the severity of respiratory distress syndrome (RDS) and plasma levels of NT-pro-BNP.
  
  
  METHODS
  Plasma levels of NT-pro-BNP were measured in premature neonates (<34 wks gestation) at 24 hours, and days 7 and 21 of life. Levels of NT-pro-BNP were compared between neonates with and without RDS.
  
  
  RESULTS
  45 neonates, 25/20 (F/M), gestational age 30 (25-33) weeks, birthweight 1290 (500-2220) g. RDS occurred in 21 (47%) neonates: RDS I (mild) = 7; RDS II (moderate) = 10; RDS III (severe) = 4. Comparative analysis revealed a significant increase in plasma level of NT pro-BNP at 24 hours (p = 0,001) and day 7 (p = 0,015) of life in patients with RDS. Plasmatic levels of NT-pro-BNP at 24 hours of age were significantly increased in patients with severe RDS than in patients with mild (p < 0,001) or moderate RDS (p < 0,002), after adjustment for gestational age and birthweight.
  
  
  CONCLUSIONS
  plasma levels of NT-pro-BNP are directly related to increasing severity of RDS in neonates, suggesting a close relation to the functional impairment of pulmonary haemodynamical changes.
authors.affiliation: Unidade Autónoma de Gestão da Mulher e da Criança, Hospital São João, Universidade do Porto, Porto.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Rocha
authors.forename: Fátima
authors.initials: F
authors.lastname: Clemente
authors.forename: Teresa
authors.initials: T
authors.lastname: Rodrigues
authors.forename: Hercília
authors.initials: H
authors.lastname: Guimarães
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011446:Prospective Studies; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain