Treatment of metronidazole-resistant Trichomonas vaginalis.
A 58-year-old Caucasian woman presented with a 14-month history of persistent trichomoniasis not responsive to numerous courses of metronidazole and tinidazole. Vaginal secretion samples were obtained for sensitivity testing and treatment recommendations. In vitro susceptibility testing revealed the patient's Trichomonas vaginalis isolate was highly resistant to both metronidazole and tinidazole. She was treated with topical furazolidone and experienced a complete symptomatic cure and culture remained negative 35 days post furazolidone treatment.
Goldman
Linda M
LM
The David Geffen School of Medicine, UCLA, 200 Medical Plaza Suite #430, Los Angeles, CA 90095, USA. lgoldman@mednet.ucla.edu
Upcroft
Jacqueline A
JA
Workowski
Kimberly
K
Rapkin
Andrea
A
D000994:Antitrichomonal Agents / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D005260:Female; D005664:Furazolidone / Q000008:administration & dosage*; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged; D014011:Tinidazole / Q000008:administration & dosage; D016896:Treatment Outcome; D014247:Trichomonas Vaginitis / Q000188:drug therapy*; D014246:Trichomonas vaginalis / Q000187:drug effects
D000994:Antitrichomonal Agents; D014011:Tinidazole; D008795:Metronidazole; D005664:Furazolidone