Bio-transformation of artemisinin using soil microbe: Direct C-acetoxylation of artemisinin at C-9 by Penicillium simplissimum.
Potent antimalarial compound artemisinin, 1 was bio-transformed to C-9 acetoxy artemisinin, 2 using soil microbe Penicillium simplissimum along with C-9 hydroxy derivative 3. The products were characterized using high field NMR and MS-MS data. The absolute stereochemistry of the newly generated chiral centers has been ascertained by COSY and 1D NOESY experiments. This is the first Letter of direct C-acetoxylation of artemisinin using microbial strains.
Goswami
Abhishek
A
Natural Products Chemistry Division, North-East Institute of Science & Technology (CSIR), Jorhat 785 006, Assam, India.
Saikia
Partha P
PP
Barua
Nabin C
NC
Bordoloi
Manobjyoti
M
Yadav
Archana
A
Bora
Tarun C
TC
Gogoi
Binod K
BK
Saxena
Ajit Kumar
AK
Suri
Nithasa
N
Sharma
Madhunika
M
D000962:Antimalarials / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D037621:Artemisinins / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D001711:Biotransformation; D002460:Cell Line; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010407:Penicillium / Q000378:metabolism*; D012988:Soil Microbiology; D012989:Soil Pollutants / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D021241:Spectrometry, Mass, Electrospray Ionization
D000962:Antimalarials; D037621:Artemisinins; D012989:Soil Pollutants; C031327:artemisinin