Enantioseparation in capillary electrophoresis using 6-oligo-(lactic acid)cyclomaltoheptaose as a chiral selector.
A novel beta-cyclodextrin (beta-CD) derivative modified with a degradable and biocompatible oligo(lactic acid) (OLA) group, 6-oligo(lactic acid)cyclomaltoheptaose (6-OLA-beta-CD), was successfully synthesized and used as a chiral selector for the capillary electrophoretic (CE) resolution (R(s)) of several basic analytes. The primary purpose of the research was to explore the capability of the 6-OLA-beta-CD as a chiral selector for comparisons with beta-CD and HP-beta-CD. Substitution with the oligo(lactic acid) group at the sixth hydroxyl sites of the CD is aimed at influencing the magnitude and selectivity of the analyte-CD interactions. The chiral resolution was strongly influenced by the concentration of the CDs and buffer pH. The effects of the substitution degree (DS) and the chain length (n) of the 6-oligo(lactic acid) groups of 6-OLA-beta-CD on separations were also investigated.
Yang
Yanli
Y
School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P.R. China.
Zhu
Chenfu
C
Shen
Jian
J
Hao
Aiyou
A
D002021:Buffers; D019075:Electrophoresis, Capillary / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D009930:Organic Chemicals / Q000737:chemistry / Q000302:isolation & purification; D012995:Solubility; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
C547575:6-oligo(lactic acid)cyclomaltoheptaose; D002021:Buffers; D009930:Organic Chemicals; D047392:beta-Cyclodextrins; D014867:Water; C031215:betadex