Insulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype.
BACKGROUND
Modifications of oxidative stress are reported in hepatitis C. The relationship between insulin resistance (IR), steatosis and oxidative stress is not established.


METHODS
One hundred and eighty-seven HCV-RNA patients were assessed by determination of biochemical, metabolic and viral features, HOMA-IR and morphological alterations. In the 52-non-3 genotypes sub-group and 35 healthy individuals, thiobarbituric acid (TBARS), total glutathione (total-GSH), vitamins C and E, lycopene, beta-carotene, glutathione peroxidase (GPx), catalase and superoxide dismutase were determined.


RESULTS
In non-3 genotype patients, steatosis was associated with higher values of BMI, HOMA-IR and triglycerides. In the 52-HCV sub-group, values of TBARS, GPx and total-GSH differ from the control group. Despite these, differences could not be observed according to the presence of steatosis, patients with IR presented significant differences regarding total-GSH (p=0.019), beta-carotene (p=0.006), lycopene (p=0.005) and GPx (p=0.009).


CONCLUSIONS
In non-3 genotype HCV carries, IR, and not steatosis, is associated with modifications in serum levels of oxidative stress.
Oliveira
Ana C
AC
Division of Gastroenterology, Federal University of São Paulo, Brazil. anaol@terra.com.br
Parise
Edison R
ER
Catarino
Regina M
RM
Lanzoni
Valeria
V
Leite-Mor
Mariliza M B
MM
Simon
Karin Argenti
KA
Junqueira
Virginia B C
VB
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005234:Fatty Liver / Q000097:blood; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics / Q000502:physiology*; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000821:virology; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D055815:Young Adult
D015415:Biomarkers