title: Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors.
abstract: Keratocystic odontogenic tumor (KOT) is a benign cystic tumor that affects the jaw bones and may be associated with the nevoid basal cell carcinoma syndrome (NBCCS). Twenty-five cases diagnosed as KOT, including primary and recurrent tumors and those associated with NBCCS, were submitted to immunohistochemical study for analysis of cytokeratins (CKs) 7, 8, 10, 13, 14, 18 and 19. The results showed CK13 immunostained on the intermediate layers and upper cells. CK14 was expressed in all epithelial layers and in those areas where inflammation and subepithelial splits were present; this protein was preserved within the basal cells. CK 18 was expressed mainly in the basal layer, whereas CK19 was expressed mainly on the intermediate and superficial layers. The remaining CKs tested were not immuoreactive. The status of maturation of cytokeratin seems to be altered on KOTs, and this is not distinct when different tumors are compared.
authors.affiliation: Department of Oral Pathology, Federal University of Bahia, Salvador, Bahia, Brazil. jeanunes@ufba.br
authors.forename: Jean Nunes
authors.initials: JN
authors.lastname: Dos Santos
authors.forename: Gabriel Queiroz Vasconcelos
authors.initials: GQ
authors.lastname: Oliveira
authors.forename: Clarissa Araújo Silva
authors.initials: CA
authors.lastname: Gurgel
authors.forename: Renata Oliveira
authors.initials: RO
authors.lastname: de Souza
authors.forename: Caroline Brandi Schlaepfer
authors.initials: CB
authors.lastname: Sales
authors.forename: Alberto
authors.initials: A
authors.lastname: de Aguiar Pires Valença Neto
authors.forename: Eduardo Antônio Gonçalves
authors.initials: EA
authors.lastname: Ramos
mesh_terms: D000328:Adult; D001478:Basal Cell Nevus Syndrome / Q000473:pathology*; D001938:Brazil; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007573:Jaw Neoplasms / Q000473:pathology*; D007633:Keratins / Q000096:biosynthesis* / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009807:Odontogenic Cysts / Q000473:pathology*
chemical_list: D007633:Keratins