title: Modelling the impact of pandemic influenza A(H1N1) on UK paediatric intensive care demand.
abstract: BACKGROUND
  Each winter seasonal respiratory virus infections account for large variations in unplanned admission to UK paediatric intensive care units (PICU). The emergence of pandemic influenza A(H1N1) has been associated with a notable predominance in children and may be expected to have a significant impact on PICU provision.
  
  
  OBJECTIVE
  To derive conservative projections for PICU demand from current data and examine the effect of regional variations in bed provision.
  
  
  RESULTS
  PICU demand was estimated with the FluSurge 2.0 model using age-stratified data for the UK population and recently published conservative estimates for epidemiological parameters. The data suggest that a significant proportion of current total capacity may be required at the peak of the pandemic. Variation in per capita critical care provision across the UK leads to a wide range in potential impact at a regional level.
  
  
  CONCLUSIONS
  Contingency measures for children needing paediatric intensive care are needed to absorb the likely increase in activity expected due to pandemic influenza this winter. Because of variations in provision by region, the role of paediatric retrieval services will be especially important.
authors.affiliation: Cambridge University Department of Anaesthesia, Box 93, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK. ae105@cam.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Ercole
authors.forename: D K
authors.initials: DK
authors.lastname: Menon
authors.forename: D R
authors.initials: DR
authors.lastname: O'Donnell
mesh_terms: D001509:Bed Occupancy / Q000706:statistics & numerical data; D002648:Child; D004196:Disease Outbreaks; D006302:Health Services Research / Q000379:methods; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000453:epidemiology* / Q000628:therapy; D015278:Intensive Care Units, Pediatric / Q000706:statistics & numerical data*; D017146:Models, Organizational; D020380:Needs Assessment; D006113:United Kingdom / Q000453:epidemiology