[Association between the number of peripheral blood stem cells and cardiac function index in patients with ischemic heart failure].
OBJECTIVE
To observe the association between the number of peripheral blood stem cells (PBSC) and cardiac function index (NYHA grade, left ventricular ejection fraction, LVEF, N-terminal-proB-type Natriuretic Peptide, NT-pro BNP) in patients with ischemic heart failure (IHF).


METHODS
A total of 199 patients hospitalized in our department between August 2007 and April 2008 due to IHF were included in this study. NYHA grade, LVEF (measured by echocardiography), plasma NT-proBNP and number of PBSC were analyzed.


RESULTS
PBSC number was significantly decreased in proportion with increasing NYHA grade and PBSC number was significantly lower in patients with NYHA IV than that with class II and III (all P<0.01). LVEF was positively correlated with PBSC number (r = 0.35, P = 0.001), NT-proBNP was negatively correlated with PBSC number (r = - 0.39, P = 0.009). Multiple regression analysis showed that LVEF and NT-proBNP were major determinants of PBSC (Beta = 0.14, - 0.25, 95% CI = -0.01 - 0.02, -0.18 - -0.04, P<0.05, P<0.01).


CONCLUSIONS
PBSC number was significantly correlated to cardiac function in IHF patients.
Zhou
Yu-ping
YP
Department of Cardiology, Guang' an' men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
Hu
Yuan-hui
YH
Wu
Hua-qin
HQ
An
Cheng
C
Wang
Jie
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology*; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000503:physiopathology*; D010446:Peptide Fragments / Q000097:blood; D011379:Prognosis; D012044:Regression Analysis; D018487:Ventricular Dysfunction, Left
D010446:Peptide Fragments