title: Vitamin D-related changes in physical performance: a systematic review.
abstract: OBJECTIVE
  The objective of this study was to systematically review all the published articles examining the effects of low serum vitamin D concentration and vitamin D supplementation on muscle, balance and gait performance among people aged 65 and older.
  
  
  METHODS
  An English and French Medline search ranging from January 2004 to November 2008 indexed under the Medical Subject Heading (MeSH) terms "aged OR aged, 80 and over" AND "Vitamin D OR Vitamin D Deficiency" combined with the terms "Gait" OR "Gait Apraxia" OR "Gait Disorders, Neurologic" OR "Walking" OR "Mobility Limitation" OR "Polyneuropathy" OR "Proprioception" OR "Ataxia" OR "Accidental Falls" was performed.
  
  
  RESULTS
  Of the 102 selected studies, 16 met the selection criteria and were included in the final analysis. There were 8 observational studies and 8 interventional studies. The number of participants ranged from 24 to 33067. A majority of studies examined community-dwelling older women. Five observational studies showed a significant positive association, whereas three studies did not. Four of the 5 studies and two of the 3 studies which tested the vitamin D supplementation effect, respectively on balance and gait, showed no significant effect. Four studies showed a significant effect on muscle strength, while this effect was not observed in three others studies. In addition, there was no significant association between vitamin D supplementation and an improvement of the sit-to-stand test results in 50% of the studies.
  
  
  CONCLUSIONS
  The findings show that the association between vitamin D and physical performance remains controversial. Observational studies and clinical trials yielded divergent results, which highlights the complex and to date still poorly understood association between serum vitamin D concentration or vitamin D supplementation and physical performance.
authors.affiliation: Department of Internal Medicine and Geriatrics, Angers University Hospital, France.
authors.forename: C
authors.initials: C
authors.lastname: Annweiler
authors.forename: A M
authors.initials: AM
authors.lastname: Schott
authors.forename: G
authors.initials: G
authors.lastname: Berrut
authors.forename: B
authors.initials: B
authors.lastname: Fantino
authors.forename: O
authors.initials: O
authors.lastname: Beauchet
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000502:physiology; D019587:Dietary Supplements; D005260:Female; D005684:Gait / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000502:physiology; D010809:Physical Fitness; D004856:Postural Balance / Q000187:drug effects* / Q000502:physiology; D014807:Vitamin D / Q000008:administration & dosage* / Q000097:blood*
chemical_list: D014807:Vitamin D