title: Sevoflurane with or without antiemetic prophylaxis of dexamethasone in spontaneously breathing patients undergoing outpatient anorectal surgery.
abstract: OBJECTIVE
  To evaluate the prophylactic use of dexamethasone with sevoflurane in outpatient anorectal surgery.
  
  
  METHODS
  Randomized, controlled study.
  
  
  METHODS
  Operating room and Postanesthesia Care Unit of a general hospital.
  
  
  METHODS
  60 adult, ASA physical status I and II outpatients undergoing anorectal surgery.
  
  
  METHODS
  Patients were randomized to receive either dexamethasone 5 mg intravenously (IV; Group D; n = 30) or an equal volume of saline (Group S; n = 30) before anesthesia induction. Anesthesia was induced with propofol 2.5 mg.kg(-1), fentanyl two microg.kg(-1), and 2% lidocaine one mg.kg(-1) followed by placement of a Laryngeal Mask Airway.
  
  
  METHODS
  Frequency of postoperative nausea and vomiting (PONV), visual analog scale (VAS) pain scores, and patient satisfaction were recorded.
  
  
  RESULTS
  Frequency of PONV and VAS pain scores were significantly lower in Group D than Group S (P < 0.05). The time required for "home readiness" was significantly shorter in Group D than Group S (P < 0.05).
  
  
  CONCLUSIONS
  The prophylactic administration of 5 mg dexamethasone IV can reduce the frequency of PONV, lower VAS pain scores, facilitate recovery to home readiness, and improve satisfaction in outpatients undergoing anorectal surgery.
authors.affiliation: Department of Anesthesia, Kaohsiung Municipal Min-Sheng Hospital, Kaohsiung 80276, Taiwan.
authors.forename: Jyh-I
authors.initials: JI
authors.lastname: Wu
authors.forename: Shao-Fong
authors.initials: SF
authors.lastname: Lu
authors.forename: Yuan-Yi
authors.initials: YY
authors.lastname: Chia
authors.forename: Lin-Cheng
authors.initials: LC
authors.lastname: Yang
authors.forename: Wen-Po
authors.initials: WP
authors.lastname: Fong
authors.forename: Ping-Heng
authors.initials: PH
authors.lastname: Tan
mesh_terms: D000328:Adult; D000556:Ambulatory Surgical Procedures; D001003:Anal Canal / Q000601:surgery*; D000768:Anesthesia, General / Q000009:adverse effects*; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D053208:Kaplan-Meier Estimate; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects*; D008875:Middle Aged; D009609:Nitrous Oxide; D010149:Postoperative Pain / Q000453:epidemiology; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology / Q000517:prevention & control*; D012007:Rectum / Q000601:surgery*; D000077149:Sevoflurane; D016896:Treatment Outcome
chemical_list: D018685:Anesthetics, Inhalation; D000932:Antiemetics; D008738:Methyl Ethers; D000077149:Sevoflurane; D003907:Dexamethasone; D009609:Nitrous Oxide