title: Associations between leisure-time physical activity and health-related quality of life among adolescent and adult survivors of childhood cancers.
abstract: OBJECTIVE
  Survivors of childhood cancer are at an increased risk for reduced quality of life (QOL), yet few studies have explored factors associated with improving health-related QOL (HRQOL) in this population. We thus explored the relationship between physical activity (PA) and HRQOL among survivors of childhood cancer.
  
  
  METHODS
  A total of 215 survivors of childhood lymphoma, leukemia, and central nervous system cancers completed mailed surveys that elicited information regarding leisure-time PA (LTPA) measured in metabolic equivalents, HRQOL, and diagnostic and demographic factors. Correlations and adjusted regression models were used to explore the relationship between LTPA and HRQOL.
  
  
  RESULTS
  In the total sample, modest, yet significant linear associations were observed between LTPA and overall HRQOL (beta=0.17, p<0.01), as well as each of the respective subscales (beta=0.11-0.23 and p's<0.05 to <0.001). Among adolescent survivors of childhood cancer, LTPA was significantly associated with overall HRQOL (beta=0.27), cancer worry (beta=0.36), cognitive function (beta=0.32), body appearance (beta=0.29), and social function (beta=0.27) (all p's<0.05). Among adult survivors of childhood cancer, LTPA was only significantly associated with physical function (beta=0.28, p<0.001).
  
  
  CONCLUSIONS
  Significant associations exist between LTPA and HRQOL; however, the association was stronger and observed in more domains for adolescent survivors of childhood cancer. More research is needed to determine the antecedents and consequences of PA in this population.
authors.affiliation: Department of Health Disparities Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77230-1439, USA. rjpaxton@mdanderson.org
authors.forename: Raheem J
authors.initials: RJ
authors.lastname: Paxton
authors.forename: Lee W
authors.initials: LW
authors.lastname: Jones
authors.forename: Philip M
authors.initials: PM
authors.lastname: Rosoff
authors.forename: Melanie
authors.initials: M
authors.lastname: Bonner
authors.forename: Joann L
authors.initials: JL
authors.lastname: Ater
authors.forename: Wendy
authors.initials: W
authors.lastname: Demark-Wahnefried
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006801:Humans; D007899:Leisure Activities; D016015:Logistic Models; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009369:Neoplasms / Q000453:epidemiology / Q000523:psychology / Q000534:rehabilitation; D011788:Quality of Life; D011795:Surveys and Questionnaires; D017741:Survivors / Q000523:psychology*; D055815:Young Adult