Reduction in HER-2 protein expression in a breast tumor HER-2 positive after only one injection of Trastuzumab: a case report.
HER-2 is overexpressed in 20 to 30% of breast cancer. Generally, metastases of a breast tumor have the same HER-2 status, although some discordances were reported.We report a case of reduction in HER-2 expression assessed by immunohistochemistry, following one day of a Trastuzumab injection, of a metastatic breast cancer to lymph nodes. Initially, the breast tumor HER-2 status was positive according to the same technique.We raise a hypothesis about technical interference and discuss the case in the framework of the existing literature.
Elghissassi
Ibrahim
I
Department of Medical Oncology, National institute of Oncology, Rabat, Morocco. i_elghissassi@hotmail.com
Inrhaoun
Hanane
H
Vignot
Stephane
S
Mrabti
Hind
H
Errihani
Hassan
H