Stepwise sequential screening for trisomy 21 in assisted reproduction pregnancies.
We offered a modified stepwise sequential integrated screening for Down syndrome to 72 singleton and 16 twin pregnancies obtained with assisted reproductive techniques, observing no cases of trisomy 21 and obtaining a false positive rate of 10% in singleton and 7% in twin pregnancies. In our population, this approach for regulating access to invasive karyotyping can avoid a substantial number of unnecessary procedures, comparing favourably with current practice even in spontaneous pregnancies.
Pastorino
Daniela
D
U.O. Ostetricia e Ginecologia, Istituto G. Gaslini, Università di Genova, Italy.
Canini
Silvana
S
Prefumo
Federico
F
Buffi
Davide
D
Pugliese
Monica
M
Venturini
Pier Luigi
PL
de Biasio
Pierangela
P
D000328:Adult; D004314:Down Syndrome / Q000175:diagnosis*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged; D009098:Multiphasic Screening / Q000379:methods*; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011296:Prenatal Diagnosis / Q000379:methods*; D027724:Reproductive Techniques, Assisted