Vitamin D receptor polymorphisms and prognosis of patients with epithelial ovarian cancer.
BACKGROUND
Recently, the vitamin D receptor (VDR) polymorphism FokI was shown to be associated with susceptibility to ovarian cancer. We aimed to examine whether VDR FokI polymorphisms influence the survivals of patients with epithelial ovarian cancer (EOC).


METHODS
VDR polymorphisms from FokI in 101 patients with EOC were genotyped by sequencing. Overall survival was compared between FokI single nucleotide polymorphism using Kaplan-Meier survival curves with log-rank tests and the Cox proportional hazard model adjusted for ages, stages, histology, and existence of residual tumour.


RESULTS
The FokI C/C genotypes were associated with better prognosis compared with the C/T and T/T genotypes (log-rank test: P = 0.008; adjusted hazard ratio, 0.18; 95%CI 0.05-0.61; P = 0.006).


CONCLUSIONS
These results suggest that the VDR polymorphisms from the FokI genotype may be associated with improved prognosis of patients with EOC.
Tamez
S
S
Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan.
Norizoe
C
C
Ochiai
K
K
Takahashi
D
D
Shimojima
A
A
Tsutsumi
Y
Y
Yanaihara
N
N
Tanaka
T
T
Okamoto
A
A
Urashima
M
M
D000328:Adult; D015331:Cohort Studies; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics* / Q000401:mortality; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000401:mortality; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016016:Proportional Hazards Models; D018167:Receptors, Calcitriol / Q000235:genetics*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood
D018167:Receptors, Calcitriol; D014807:Vitamin D; C104450:25-hydroxyvitamin D; C035042:endodeoxyribonuclease FokI; D015252:Deoxyribonucleases, Type II Site-Specific