Copper-catalyzed tandem nucleophilic ring-opening/intramolecular oxidative amidation of N-tosylaziridines and hydrazones under aerobic conditions.
A novel and efficient copper-catalyzed tandem reaction of N-tosylaziridines and hydrazones under aerobic conditions to afford the functionalized tetrahydrotriazines is described. The process involves a nucleophilic ring-opening and an intramolecular oxidative amidation.
Hong
Deng
D
Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
Lin
Xufeng
X
Zhu
Yuanxun
Y
Lei
Ming
M
Wang
Yanguang
Y
D001388:Aziridines / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003500:Cyclization; D006835:Hydrazones / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D010084:Oxidation-Reduction; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry
D001388:Aziridines; D006835:Hydrazones; D014227:Triazines; D003300:Copper