Heart diseases in mitochondrial encephalomyopathy, lactic acidosis, and stroke syndrome.
Mitochondrial encephalomyopathy, lactic acidosis, and stroke (MELAS) syndrome is a mitochondrial genetic disorder caused by a point mutation, resulting in the substitution of guanine for adenine at nucleotide 3243 (A3243G) of mitochondrial DNA. This disease is characterized by a multisystem disorder with variable manifestations. The authors review heart involvement in this disease.
Fayssoil
Abdallah
A
Critical Care Medicine, Boulevard Raymond-Poincare, Raymond Poincare Hospital, Garches, Ile de France 92380, France. fayssoil2000@yahoo.fr
D000818:Animals; D009202:Cardiomyopathies / Q000150:complications / Q000235:genetics / Q000473:pathology; D004272:DNA, Mitochondrial / Q000502:physiology; D003937:Diagnosis, Differential; D006331:Heart Diseases / Q000150:complications* / Q000235:genetics; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000235:genetics; D017241:MELAS Syndrome / Q000150:complications* / Q000235:genetics / Q000628:therapy; D017354:Point Mutation; D012307:Risk Factors; D014927:Wolff-Parkinson-White Syndrome / Q000150:complications / Q000235:genetics
D004272:DNA, Mitochondrial