title: A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro.
abstract: A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B*5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B*5701-related effect or other functional variants in the haplotype or both.
authors.affiliation: Center for Human Genome Variation, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA.
authors.forename: Woohyun
authors.initials: W
authors.lastname: Yoon
authors.forename: Ben-Jiang
authors.initials: BJ
authors.lastname: Ma
authors.forename: Jacques
authors.initials: J
authors.lastname: Fellay
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Shi-Mao
authors.initials: SM
authors.lastname: Xia
authors.forename: Ruijun
authors.initials: R
authors.lastname: Zhang
authors.forename: Kevin V
authors.initials: KV
authors.lastname: Shianna
authors.forename: Hua-Xin
authors.initials: HX
authors.lastname: Liao
authors.forename: Barton F
authors.initials: BF
authors.lastname: Haynes
authors.forename: David B
authors.initials: DB
authors.lastname: Goldstein
mesh_terms: D015658:HIV Infections / Q000235:genetics* / Q000821:virology; D015497:HIV-1 / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D019562:Viral Load
chemical_list: C080521:HCP5 long noncoding RNA, human; D015235:HLA-B Antigens; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated