title: MRI measures of Alzheimer's disease and the AddNeuroMed study.
abstract: Here we describe the AddNeuroMed multicenter magnetic resonance imaging (MRI) study for longitudinal assessment in Alzheimer's disease (AD). The study is similar to a faux clinical trial and has been established to assess longitudinal MRI changes in AD, mild cognitive impairment (MCI), and healthy control subjects using an image acquisition protocol compatible with the Alzheimer's Disease Neuroimaging Initiative (ADNI). The approach consists of a harmonized MRI acquisition protocol across centers, rigorous quality control, a central data analysis hub, and an automated image analysis pipeline. Comprehensive quality control measures have been established throughout the study. An intelligent web-accessible database holds details on both the raw images and data processed using a sophisticated image analysis pipeline. A total of 378 subjects were recruited (130 AD, 131 MCI, 117 healthy controls) of which a high percentage (97.3%) of the T1-weighted volumes passed the quality control criteria. Measurements of normalized whole brain volume, whole brain cortical thickness, and point-by-point group-based cortical thickness measurements, demonstrating the power of the automated image analysis techniques employed, are reported.
authors.affiliation: NIHR Specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and King's College London and the MRC Centre for Neurodegeneration, King's College London, Institute of Psychiatry, London SE5 8AF, United Kingdom. andy.simmons@kcl.ac.uk
authors.forename: Andrew
authors.initials: A
authors.lastname: Simmons
authors.forename: Eric
authors.initials: E
authors.lastname: Westman
authors.forename: Sebastian
authors.initials: S
authors.lastname: Muehlboeck
authors.forename: Patrizia
authors.initials: P
authors.lastname: Mecocci
authors.forename: Bruno
authors.initials: B
authors.lastname: Vellas
authors.forename: Magda
authors.initials: M
authors.lastname: Tsolaki
authors.forename: Iwona
authors.initials: I
authors.lastname: Kłoszewska
authors.forename: Lars-Olof
authors.initials: LO
authors.lastname: Wahlund
authors.forename: Hilkka
authors.initials: H
authors.lastname: Soininen
authors.forename: Simon
authors.initials: S
authors.lastname: Lovestone
authors.forename: Alan
authors.initials: A
authors.lastname: Evans
authors.forename: Christian
authors.initials: C
authors.lastname: Spenger
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000473:pathology*; D016022:Case-Control Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male