Effects of cefaclor on gastric emptying and cholecystokinin release in healthy humans.
OBJECTIVE
In rodents, cephalosporin antibiotics can mimic peptones and stimulate release of cholecystokinin (CCK), a hormone that slows gastric emptying. The rate of gastric emptying is a major determinant of postprandial blood glucose and insulin concentrations. We therefore evaluated the effect of orally administered cefaclor on plasma CCK and gastric emptying, as well as postprandial glycemic and insulinemic responses, in healthy humans.


METHODS
We studied 8 healthy subjects on two days in double-blind, randomized order. On each day, subjects consumed 1000 mg cefaclor or placebo 30 min before a mashed potato meal labeled with (13)C octanoic acid. Blood and breath samples were collected for 4h after the meal.


RESULTS
Blood glucose, serum insulin and plasma CCK increased in response to the carbohydrate meal on both study days, and cefaclor had no effect on these responses. Similarly, the gastric half-emptying time (measured by breath test) did not differ (placebo: 137.5+/-6.0 min vs. cefaclor: 143.1+/-8.0 min).


CONCLUSIONS
Cefaclor, when given before a meal in the form of a capsule, does not stimulate CCK release or slow gastric emptying in healthy humans.
Ma
Jing
J
University of Adelaide, Discipline of Medicine, Royal Adelaide Hospital, Adelaide, Australia.
Bellon
Max
M
Wishart
Judith M
JM
Young
Richard L
RL
Jones
Karen L
KL
Horowitz
Michael
M
Rayner
Christopher K
CK
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001786:Blood Glucose / Q000378:metabolism*; D002210:Caprylates / Q000494:pharmacology; D002247:Carbon Isotopes / Q000494:pharmacology; D002433:Cefaclor / Q000008:administration & dosage*; D002766:Cholecystokinin / Q000097:blood*; D004311:Double-Blind Method; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D010461:Peptones / Q000378:metabolism; D011198:Solanum tuberosum
D000900:Anti-Bacterial Agents; D001786:Blood Glucose; D002210:Caprylates; D002247:Carbon Isotopes; D007328:Insulin; D010461:Peptones; D002433:Cefaclor; D002766:Cholecystokinin; C031492:octanoic acid