[State of neuromediator systems in rat cerebellum and brain stem upon single intake of morphine].
The state of neuromediator systems in the cerebellum and brain stem was studied in rats upon acute morphine intoxication. The drug intake in a single doze of 10 mg/kg is accompanied by a decrease in the levels of dopamine, serotonin, and GABA in the cerebellum. Upon the intake of 20 mg/kg morphine, the contents of dopamine and serotonin in the cerebellum are also lower than in the untreated control, while only the first neuromediator concentration decreases in the brain stem. The administration of morphine in a doze of 40 mg/kg only reduces the level of dopamine in the cerebellum.
Lelevich
S V
SV
Doroshenko
E M
EM
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002531:Cerebellum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009020:Morphine / Q000009:adverse effects* / Q000494:pharmacology; D009294:Narcotics / Q000009:adverse effects* / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D009294:Narcotics; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D009020:Morphine; D004298:Dopamine