Near-infrared fluorescent nanoGUMBOS for biomedical imaging.
Herein, we report on near-infrared (NIR) fluorescent nanoparticles generated from an emergent class of materials we refer to as a Group of Uniform Materials Based on Organic Salts (GUMBOS). GUMBOS are largely frozen ionic liquids, although the concept is more general and is also easily applied to solid ionic materials with melting points in excess of 100 degrees C. Nanoparticles based on GUMBOS (nanoGUMBOS) derived from a NIR fluorophore are prepared using a reprecipitation method and evaluated for in vivo fluorescence imaging. Due to their uniformity, single-step preparation, and composite nature, nanoGUMBOS help to resolve issues with dye leakage problems innate to alternate cellular stains and unlock a myriad of applications for these materials, highlighting exciting possibilities for multifunctional nanoGUMBOS.
Bwambok
David K
DK
Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.
El-Zahab
Bilal
B
Challa
Santhosh K
SK
Li
Min
M
Chandler
Lin
L
Baker
Gary A
GA
Warner
Isiah M
IM
D003287:Contrast Media / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D007089:Image Enhancement / Q000379:methods; D052578:Ionic Liquids / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008856:Microscopy, Fluorescence / Q000379:methods*; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013499:Surface Properties
D003287:Contrast Media; D052578:Ionic Liquids; D046911:Macromolecular Substances