title: Development of Churg-Strauss syndrome with severe multiple mononeuropathy after leukotriene receptor antagonist treatment in one of the monozygotic twins with asthma: case report.
abstract: Several cases of Churg-Strauss syndrome (CSS) have been reported in asthmatic patients treated with leukotriene receptor antagonists (LTRAs). It is not clear whether LTRA is a causative factor in the development of vasculitis. We present the case of a 26-year-old patient, who developed severe central and peripheral neuropathy after a short-term treatment with LTRA, followed by gastrointestinal perforation and bleeding. The patient was successfully treated with high-dose glucocorticoids, immunoglobulins, and cyclophosphamide. His monozygotic twin brother treated for asthma does not meet classification criteria for Churg-Strauss syndrome at the moment, but his condition is being monitored. Both asthma and rheumatology specialists should consider the possibility of CSS development in patients treated with LTRAs.
authors.affiliation: Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Lublin, Poland. bozena.stepniak@am.lublin.pl
authors.forename: Bozena
authors.initials: B
authors.lastname: Targońska-Stepniak
authors.forename: Maria
authors.initials: M
authors.lastname: Majdan
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Haberek
authors.forename: Ewa
authors.initials: E
authors.lastname: Papuć
authors.forename: Kinga
authors.initials: K
authors.lastname: Wnukowska
mesh_terms: D000328:Adult; D018927:Anti-Asthmatic Agents / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy; D015267:Churg-Strauss Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D004200:Diseases in Twins / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D020024:Leukotriene Antagonists / Q000009:adverse effects*; D008297:Male; D020422:Mononeuropathies / Q000139:chemically induced* / Q000175:diagnosis; D014430:Twins, Monozygotic
chemical_list: D018927:Anti-Asthmatic Agents; D020024:Leukotriene Antagonists