title: Lymphangioma-like Kaposi sarcoma: case report.
abstract: Kaposi sarcoma (KS) is a multifocal vascular disease with uncertain histogenesis. It is characterized by clinical and histologic polymorphism. The "lymphangioma-like" variant is very uncommon, accounting for less than 5% of all cases. We report the case of a 76-year-old woman, HIV negative, with a 4-year history of classic Kaposi sarcoma treated with cryotherapy who developed new bullous lesions on her lower extremities. Biopsy revealed histologic findings of lymphangioma-like KS (LLKS), together with areas of classic KS; HHV-8 staining was positive. Diagnosis of LLKS was made and the patient was proposed for radiotherapy. The lymphangioma-like Kaposi sarcoma is a rare morphologic expression of KS characterized by dilated and bizarrely shaped vascular channels lined by flattened endothelium permeating the dermis. "Bulla-like" lesions have been considered as a clinical hallmark of this variant. Its histologic appearance suggests a lymphatic origin of KS and it may resemble other vascular tumors. Findings of areas of typical KS and positive staining for HHV-8 may help to make a definitive diagnosis.
authors.affiliation: Complexo Hospitalario de Pontevedra.
authors.forename: Celia
authors.initials: C
authors.lastname: Posada García
authors.forename: Aranzazu
authors.initials: A
authors.lastname: García-Cruz
authors.forename: Ignacio
authors.initials: I
authors.lastname: García-Doval
authors.forename: Carlos
authors.initials: C
authors.lastname: De La Torre
authors.forename: Manuel José
authors.initials: MJ
authors.lastname: Cruces
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D017679:Cryotherapy; D003937:Diagnosis, Differential; D005260:Female; D018023:HIV Seronegativity; D019288:Herpesvirus 8, Human / Q000302:isolation & purification; D006801:Humans; D007866:Leg; D008202:Lymphangioma / Q000175:diagnosis*; D012514:Sarcoma, Kaposi / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy / Q000821:virology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy / Q000821:virology