title: Remission of splenic volume in the recipient during the course of adult-to-adult living donor liver transplantation: evaluation using multislice computed tomography and semiautomatic software.
abstract: OBJECTIVE
  The purpose of the study was to examine changes in splenic volume among recipients during the course of adult-to-adult living donor liver transplantation (LDLT) using multislice computed tomography (CT) scanning with a semiautomatic volumetry software.
  
  
  METHODS
  Forty-eight patients, including 33 males and a mean overall age of 54 +/- 8 years), underwent liver transplantation for the primary disease of liver cirrhosis with or without hepatocellular carcinoma (n = 31/17, respectively). The mean MELD score was 14 +/- 6. The liver graft mass compared with recipient weight was 74% +/- 28%. Splenic artery embolization was not performed. Dynamic CT scans splenic volume, and platelet counts (10(3)/cm(3)) were obtained pre, < or =50 day and > or =90 days postoperatively.
  
  
  RESULTS
  The total time to generate volumetry and image postprocessing per examination was <10 minutes. One-factor analysis of variance (ANOVA) revealed that the average splenic volume tended to be reduced from pre- to post-LDLT, although not significantly: pre-LDLT, 469 +/- 270 mL; < or =day 50, 369 +/- 212 mL; and > or =day 90, 378 +/- 210 mL (P = .066). One-factor ANOVA revealed that the average platelet count was significantly different in the 3 periods: pre-LDLT, 69 +/- 32 x 10(3)/cm(3); < or =day 50, 181 +/- 253 x 10(3)/cm(3); and > or =day 90, 126 +/- 64 x 10(3)/cm(3) (P < .01). The post hoc Scheffé test revealed the statistical significance of the platelet counts between pre-LDLT and < or =day 50 (P < .01).
  
  
  CONCLUSIONS
  Splenic volumetry with multislice CT and semiautomatic software, which is simple and not time consuming, was able to evaluate remission from hypersplenism during the course of LDLT.
authors.affiliation: Department of Clinical Radiology, Hiroshima University Hospital, Hiroshima, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ishifuro
authors.forename: J
authors.initials: J
authors.lastname: Horiguchi
authors.forename: A
authors.initials: A
authors.lastname: Ohshita
authors.forename: T
authors.initials: T
authors.lastname: Itamoto
authors.forename: H
authors.initials: H
authors.lastname: Ohdan
authors.forename: K
authors.initials: K
authors.lastname: Ito
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D006801:Humans; D008099:Liver / Q000033:anatomy & histology; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000601:surgery*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery; D016031:Liver Transplantation / Q000000981:diagnostic imaging*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D010976:Platelet Count; D012189:Retrospective Studies; D013154:Spleen / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D015898:Tomography Scanners, X-Ray Computed; D014057:Tomography, X-Ray Computed / Q000379:methods*