A gold(III) ion-selective fluorescent probe and its application to bioimagings.
A highly selective and sensitive fluorescent chemosensor for Au(3+) has been reported. The system utilizes an irreversible Au(3+)-promoted cyclization reaction of a rhodamine amide tethered with an alkyne. The probe can sense Au(3+) ions selectively over other biologically relevant metal ions, and approximately 50 nM of Au(3+) could be readily detected in aqueous media. Fluorescent imaging of Au(3+) in living cells is also successfully demonstrated.
Yang
Young-Keun
YK
Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
Lee
Sunho
S
Tae
Jinsung
J
D015374:Biosensing Techniques; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007477:Ions; D015394:Molecular Structure
D005456:Fluorescent Dyes; D007477:Ions; D006046:Gold