title: Impact of cardiovascular risk factors on oxidative stress and DNA damage in a high risk Mediterranean population.
abstract: The impact of classic cardiovascular risk factors on oxidative stress status in a high-risk cardiovascular Mediterranean population of 527 subjects was estimated. Oxidative stress markers (malondialdehyde, 8-oxo-7'8'-dihydro-2'-deoxyguanosine, oxidized/reduced glutathione ratio) together with the activity of antioxidant enzyme triad (superoxide dismutase, catalase, glutathione peroxidase) were analysed in circulating mononuclear blood cells. Malondialdehyde, oxidized glutathione and the ratio of oxidized to reduced glutathione were significantly higher while catalase and glutathione peroxidase activities were significantly lower in high cardiovascular risk participants than in controls. Statistically significant differences were obtained after additional multivariate control for sex, age, obesity, diabetes, lipids and medications. Among the main cardiovascular risk factors, hypertension was the strongest determinant of oxidative stress in high risk subjects studied at a primary prevention stage.
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Medicine, School of Medicine, University of Valencia, Valencia, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Fandos
authors.forename: Dolores
authors.initials: D
authors.lastname: Corella
authors.forename: Marisa
authors.initials: M
authors.lastname: Guillén
authors.forename: Olga
authors.initials: O
authors.lastname: Portolés
authors.forename: Paula
authors.initials: P
authors.lastname: Carrasco
authors.forename: Antonio
authors.initials: A
authors.lastname: Iradi
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Martínez-González
authors.forename: Ramón
authors.initials: R
authors.lastname: Estruch
authors.forename: Maria I
authors.initials: MI
authors.lastname: Covas
authors.forename: Rosa María
authors.initials: RM
authors.lastname: Lamuela-Raventós
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Michavilla
authors.forename: Concha
authors.initials: C
authors.lastname: Cerdá
authors.forename: Rafael
authors.initials: R
authors.lastname: Torregrosa
authors.forename: Josep
authors.initials: J
authors.lastname: Redón
authors.forename: Francisco Felipe
authors.initials: FF
authors.lastname: Chaves
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Tormos
authors.forename: Dolores
authors.initials: D
authors.lastname: Ocete
authors.forename: Guillermo T
authors.initials: GT
authors.lastname: Sáez
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012307:Risk Factors; D012737:Sex Factors; D013030:Spain / Q000453:epidemiology