Focal adhesion plaque associated cytoskeletons are involved in the invasion and metastasis of human colorectal carcinoma.
The protein and mRNA expression of focal adhesion plaque associated cytoskeletons, including talin, vinculin, paxillin, and tensin, was studied using immunofluorescence in combination with confocal laser scanning microscopy and fluorescent quantitative polymerase chain reaction in 41 matched samples of human normal colorectal mucosae, primary colorectal adenocarcinomas, and 19 separate lymph node metastases. All specimens showed expression. The results showed talin, vinculin, tensin, and paxillin expression were correlated with carcinogenesis, invasion, and metastasis of colorectal carcinoma (CRC). Talin, vinculin, and tensin underwent downregulation while paxillin went up. So these cytoskeletons may play bidirectional regulating roles during the progression of CRC.
Yang
Hong-Jun
HJ
Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Chen
Juan-Zhi
JZ
Zhang
Wen-Li
WL
Ding
Yan-Qing
YQ
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D022001:Focal Adhesions / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness
D003598:Cytoskeletal Proteins