Plasma adiponectin level and sleep structures in children with Prader-Willi syndrome.
Adiponectin, an adipose tissue-derived hormone, has been negatively related to obstructive sleep apnea syndrome. Besides sleep apnea, children with Prader-Willi syndrome (PWS) may have excessive daytime sleepiness and rapid eye movement (REM) sleep abnormality. The aim of this study is to determine whether changes in sleep structures are related to plasma adiponectin levels in PWS. Correlations between adiponectin level and sleep variables were analyzed in 28 children with PWS and 18 controls. Overnight polysomnography was performed. The fasting plasma adiponectin levels were higher in the children with PWS than in the controls (P = 0.0006). In the PWS, Epworth sleepiness scale was significantly higher (P = 0.002); sleep latency (P = 0.003) and REM latency (P = 0.001) were significantly shortened; the apnea-hypopnea index (AHI) was significantly increased (P = 0.0001); and the duration of non-rapid eye movement (NREM) sleep stages 3 and 4 was decreased (P = 0.005). Multiple regression analysis revealed correlations between the adiponectin level and the total sleep time (beta = 0.688, P = 0.009), AHI (beta = 1.274, P = 0.010), REM latency (beta = -0.637, P = 0.021) and the percentage of NREM sleep (beta = -7.648, P = 0.002) in PWS. In children with PWS, higher plasma adiponectin levels were independently associated with several sleep variables, which was not observed in the control group. These results suggest a potential influence of elevated adiponectin level on the sleep structures in PWS.
Joo
Eun Yeon
EY
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Il-Won Dong, Seoul, Korea.
Hong
Seung Bong
SB
Sohn
Young Bae
YB
Kwak
Min Jung
MJ
Kim
Su Jin
SJ
Choi
Young Ok
YO
Kim
Seon Woo
SW
Paik
Kyung-Hoon
KH
Jin
Dong-Kyu
DK
D052242:Adiponectin / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D006970:Disorders of Excessive Somnolence / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D017286:Polysomnography; D011218:Prader-Willi Syndrome / Q000097:blood* / Q000453:epidemiology*; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000453:epidemiology*; D012894:Sleep Stages / Q000502:physiology
D052242:Adiponectin; D001786:Blood Glucose