title: Nephrogenic syndrome of inappropriate antidiuresis: a novel cause of euvolemic hypotonic hyponatremia in newborns. Diagnosis and practical management.
abstract: Hyponatremia, defined by a serum sodium concentration of less than 135 mmmol/l, is a complex clinical occurrence frequently manifested in newborns admitted to the neonatal intensive care unit. The pathogenetic mechanisms and clinical timing underlying the onset of hyponatremia have not been well established in the newborn. Aim of this review is to present a practical approach and management of hypotonic hyponatremia in newborns, with particular emphasis on nephrogenic syndrome of inappropriate antidiuresis, recently described by us for the first time in the literature in a newborn.
authors.affiliation: Department of Pediatrics and Clinical Medicine-Section of Neonatal Intensive Care Unit, Puericultura Institute and Neonatal Section, Azienda Mista and University of Cagliari, Italy.
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Marcialis
authors.forename: Angelica
authors.initials: A
authors.lastname: Dessì
authors.forename: Silvia
authors.initials: S
authors.lastname: Contu
authors.forename: Vassilios
authors.initials: V
authors.lastname: Fanos
mesh_terms: D000284:Administration, Oral; D018500:Diabetes Insipidus, Nephrogenic / Q000235:genetics / Q000628:therapy; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007010:Hyponatremia / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D020925:Hypoxia-Ischemia, Brain / Q000150:complications / Q000503:physiopathology; D007177:Inappropriate ADH Syndrome / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009481:Neurophysins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011498:Protein Precursors / Q000235:genetics; D013577:Syndrome; D014508:Urea / Q000008:administration & dosage; D014667:Vasopressins / Q000235:genetics
chemical_list: C438657:AVP protein, human; D009481:Neurophysins; D011498:Protein Precursors; D014667:Vasopressins; D014508:Urea