Characterization of a polyurethane-based controlled release system for local delivery of chlorhexidine diacetate.
Conventional formulations of chlorhexidine usually provide short-term efficiency, requiring repeated applications to maintain antibacterial activity. Therefore, appropriate release system of chlorhexidine controlling local drug delivery would reduce the number of applications and enhance patient compliance. The aim of this study was to develop a controlled release system based on medical polyurethane for the local delivery of chlorhexidine diacetate (CDA). CDA-loaded polyurethane films (CDA-Films) and CDA-loaded polyurethane sandwiches (CDA-Sandwiches) were obtained by casting and solvent evaporation. The physico-chemical aspects of CDA-loaded polyurethane systems were investigated, and the crystalline state of CDA in the polymeric system was highlighted. CDA-Films exhibited appropriate mechanical properties for further applications. Drug release was measured in two different media: (i) distilled water and (ii) physiological saline solution to mimic in vivo conditions. Drug release studies were performed up to 11days on CDA-Films and 29days for CDA-Sandwiches. Release of CDA depended on drug loading and the structure of the system. In particular, release of CDA from the sandwich system followed zero-order kinetic. The release rate was significantly lower in physiological solution. Antibacterial studies were carried out on CDA-Films against Staphylococcus aureus and Staphylococcus epidermidis showing 35days persisting antibacterial activity. In conclusion, the polyurethane-based system developed in this study is potentially useful as a local delivery system for CDA and could be used not only in surgery but also in dental and clinical applications.
Huynh
Truc Thanh Ngoc
TT
Laboratoire de Recherche et Développement de Pharmacie Galénique Industrielle, Université de Lyon, Lyon 08, France.
Padois
Karine
K
Sonvico
Fabio
F
Rossi
Alessandra
A
Zani
Franca
F
Pirot
Fabrice
F
Doury
Jacques
J
Falson
Françoise
F
D000287:Administration, Topical; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D055598:Chemical Phenomena; D002710:Chlorhexidine / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D003460:Crystallization; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000008:administration & dosage / Q000138:chemical synthesis / Q000493:pharmacokinetics; D004339:Drug Compounding / Q000379:methods*; D066298:In Vitro Techniques; D007700:Kinetics; D055595:Mechanical Phenomena; D008826:Microbial Sensitivity Tests; D011108:Polymers / Q000008:administration & dosage / Q000138:chemical synthesis / Q000493:pharmacokinetics; D011140:Polyurethanes / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D012965:Sodium Chloride / Q000032:analysis; D014867:Water / Q000032:analysis
D000891:Anti-Infective Agents, Local; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D011140:Polyurethanes; D014867:Water; D012965:Sodium Chloride; D002710:Chlorhexidine