Integrins: masters and slaves of endocytic transport.
Since it has become clear that adhesion receptors are trafficked through the endosomal pathway and that this can influence their function, much effort has been invested in obtaining detailed descriptions of the molecular machinery responsible for internalizing and recycling integrins. New findings indicate that integrin trafficking dictates the nature of Rho GTPase signalling during cytokinesis and cell migration. Furthermore, integrins can exert control over the trafficking of other receptors in a way that drives cancer cell invasion and tumour angiogenesis.
Caswell
Patrick T
PT
Beatson Institute for Cancer Research, Cancer Research UK, Glasgow, G61 3BX, Scotland.
Vadrevu
Suryakiran
S
Norman
Jim C
JC
D000818:Animals; D004705:Endocytosis; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D021381:Protein Transport; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D016023:Integrins; D020741:rho GTP-Binding Proteins