title: Melatonin and human reproduction: shedding light on the darkness hormone.
abstract: Melatonin, N-acetyl-5-methoxytryptamine, is a molecule with diverse physiological functions. This neuro-hormone affects reproductive performance in a wide variety of species. In most animals, but not exclusively all, melatonin has an antigonadotrophic effect. The seasonal changes in the number of hours per day that melatonin is secreted mediate the temporal coupling of reproductive activity to seasonal changes in day-length. These observations stimulated a search for a role for the pineal gland and melatonin in human reproduction. Clinical experience related to this issue has yielded inconclusive and sometimes conflicting results. This article reviews the current available evidence concerning the effects of melatonin on human reproductive processes (e.g., puberty, ovulation, pregnancy, and fertility). Possible reasons for the vagueness and elusiveness of the clinical effects are discussed.
authors.affiliation: Sri Sathya Sai Medical Educational and Research Foundation, Prasanthi Nilayam, Coimbatore 641014, India.
authors.forename: Venkatramanujam
authors.initials: V
authors.lastname: Srinivasan
authors.forename: Warren D
authors.initials: WD
authors.lastname: Spence
authors.forename: Seithikurippu R
authors.initials: SR
authors.lastname: Pandi-Perumal
authors.forename: Rahima
authors.initials: R
authors.lastname: Zakharia
authors.forename: Kunwar P
authors.initials: KP
authors.lastname: Bhatnagar
authors.forename: Amnon
authors.initials: A
authors.lastname: Brzezinski
mesh_terms: D002940:Circadian Rhythm / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000502:physiology*; D010053:Ovary / Q000502:physiology; D010870:Pineal Gland / Q000502:physiology; D011247:Pregnancy; D012098:Reproduction / Q000502:physiology*; D013737:Testis / Q000502:physiology
chemical_list: D008550:Melatonin