Synthesis, DNA-binding, photocleavage, cytotoxicity and antioxidant activity of ruthenium (II) polypyridyl complexes.
Two new ligands maip (1a), paip (1b) with their ruthenium (II) complexes [Ru(bpy)(2)(maip)](ClO(4))(2) (2a) and [Ru(bpy)(2)(paip)](ClO(4))(2) (2b) have been synthesized and characterized. The results show that complexes 2a and 2b interact with DNA through intercalative mode. The cytotoxicity of these compounds has been evaluated by MTT assay. The experiments on antioxidant activity show that these compounds exhibit good antioxidant activity against hydroxyl radical (OH).
Liu
Yun-Jun
YJ
School of Pharmacy, Guangdong Pharmaceutical University, Guangdong, Guangzhou 510006, PR China. lyjche@163.com
Zeng
Cheng-Hui
CH
Huang
Hong-Liang
HL
He
Li-Xin
LX
Wu
Fu-Hai
FH
D000042:Absorption; D000818:Animals; D002417:Cattle; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004583:Electrons; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D017665:Hydroxyl Radical / Q000737:chemistry; D009691:Nucleic Acid Denaturation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology / Q000633:toxicity; D055668:Photochemical Processes; D011725:Pyridines / Q000737:chemistry*; D051381:Rats; D012428:Ruthenium / Q000737:chemistry*; D013057:Spectrum Analysis; D044366:Transition Temperature; D014783:Viscosity
D016166:Free Radical Scavengers; D009942:Organometallic Compounds; D011725:Pyridines; D017665:Hydroxyl Radical; D012428:Ruthenium; D004247:DNA; C023666:pyridine