The nature of cell-cycle checkpoints: facts and fallacies.
The concept of checkpoint controls revolutionized our understanding of the cell cycle. Here we revisit the defining features of checkpoints and argue that failure to properly appreciate the concept is leading to misinterpretation of experimental results. We illustrate, using the mitotic checkpoint, problems that can arise from a failure to respect strict definitions and precise terminology.
Khodjakov
Alexey
A
Wadsworth Center, Albany, NY 12201-0509, USA. khodj@wadsworth.org
Rieder
Conly L
CL
D002453:Cell Cycle / Q000502:physiology*; D018816:Genes, cdc / Q000502:physiology; D008954:Models, Biological