High-mobility group A1 (HMGA1) protein expression correlates with cisplatin-induced cell death in squamous cell carcinoma of skin.
It is well known that HMGA1 group of non-histone chromosomal proteins are up-regulated in several human cancers. We studied the HMGA1 expression in squamous cell carcinoma of skin in mice followed by the treatment with Cisplatin, which is often used in combination therapies of cancers. A short course of Cisplatin treatment led to apoptotic cell death and downregulation (by 40%) of HMGA1. However, extended treatment of Cisplatin caused necrotic cell death; concomitantly HMGA1 expression decreased by 90%. Present results indicate a strong association of HMGA1 with Cisplatin-linked tumor regression. Therefore, HMGA1 could be a potential target in designing therapeutic strategies against cancer.
Sharma
Ashok
A
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Ray
Ruma
R
Rajeswari
Moganty R
MR
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000494:pharmacology*; D005260:Female; D025741:HMGA1a Protein / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D025742:HMGA1b Protein / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D051379:Mice; D012878:Skin Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents; D025742:HMGA1b Protein; D025741:HMGA1a Protein; D002945:Cisplatin