title: Influence of maternal BMI on genetic sonography in the FaSTER trial.
abstract: OBJECTIVE
  We sought to evaluate the influence of maternal body mass index (BMI) on sonographic detection employing data from the FaSTER trial.
  
  
  METHODS
  Unselected singleton pregnancies underwent detailed genetic sonogram to evaluate for structural fetal anomalies and soft markers for aneuploidy. BMI (kg/m(2)) were calculated from reported initial visit values. Sensitivity, specificity, false positive and false negative rates (FPR and FNR), likelihood ratio, detection rates, and a missed diagnosis rate (MDR: FNR + marker recorded as 'missing'/N) were calculated.
  
  
  RESULTS
  Eight thousand five hundred and fifty-five patients with complete BMI information had detailed genetic sonography. A lower sensitivity with an elevated FNR and MDR was observed in obese women for multiple aneuploid markers (e.g. > or =2 markers 32% sensitivity with 68% FNR among BMI <25 vs 22% and 78% among BMI >30). Similarly, the detection rate for cardiac anomalies among women at BMI <25 was higher (21.6%) at a significantly lower FPR (78.4%; 95% CI 77.3-79.5%) in comparison to obese women (8.3% with FPR 91.7%; 95% CI 90.1-93.2%). In a logistic regression model, maternal obesity significantly decreased the likelihood of sonographic detection of common anomalies (adjusted OR 0.7; 95% CI 0.6-0.9; p = 0.001).
  
  
  CONCLUSIONS
  The performance of second trimester genetic sonography is influenced by obesity, with a significantly higher MDR for multiple minor markers and lower likelihood for detecting common anomalies.
authors.affiliation: University of Utah, Salt Lake City, UT, USA. aagaardt@bcm.tmc.edu
authors.forename: Kjersti M
authors.initials: KM
authors.lastname: Aagaard-Tillery
authors.forename: T
authors.initials: T
authors.lastname: Flint Porter
authors.forename: Fergal D
authors.initials: FD
authors.lastname: Malone
authors.forename: David A
authors.initials: DA
authors.lastname: Nyberg
authors.forename: Jamie
authors.initials: J
authors.lastname: Collins
authors.forename: Christine H
authors.initials: CH
authors.lastname: Comstock
authors.forename: Gary
authors.initials: G
authors.lastname: Hankins
authors.forename: Keith
authors.initials: K
authors.lastname: Eddleman
authors.forename: Lorraine
authors.initials: L
authors.lastname: Dugoff
authors.forename: Honor M
authors.initials: HM
authors.lastname: Wolfe
authors.forename: Mary E
authors.initials: ME
authors.lastname: D'Alton
mesh_terms: D000328:Adult; D000782:Aneuploidy; D015415:Biomarkers; D015992:Body Mass Index; D000013:Congenital Abnormalities / Q000000981:diagnostic imaging* / Q000235:genetics; D005260:Female; D005820:Genetic Testing / Q000379:methods; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging; D006801:Humans; D009765:Obesity / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D016216:Ultrasonography, Prenatal / Q000379:methods* / Q000706:statistics & numerical data
chemical_list: D015415:Biomarkers