Hepatic lipid peroxidation and antioxidant micronutrients in hepatitis virus C liver recipients with and without disease recurrence.
BACKGROUND
Hepatitis C virus (HCV) reinfection after liver transplantation is universal and progresses to cirrhosis in 10% to 30% of patients. Several risk factors are associated with progression. Oxidative stress may be involved because it has a role in the pathogenesis of HCV.


OBJECTIVE
To determine whether HCV liver recipients with disease recurrence are more oxidatively stressed than those with no recurrence.


METHODS
Measurements were performed at 12 months posttransplantation, and in a subgroup of patients at 6 months. Liver lipid peroxidation (LPO), antioxidant potential, plasma vitamin E, retinol, and vitamin C were measured. Demographic data, pretransplantation viral load, anthropometry, and 3-day food records were also obtained. Data were log-transformed; analysis was performed using the independent t test, Pearson correlation, and multivariate regression analysis.


RESULTS
Recipients of HCV livers with recurrence (n = 21) had higher liver LPO (mean [SEM] micromoles of malondialdehyde per gram of liver tissue, 1.66 [0.28]) vs those with no recurrence (n = 16; 0.88 [0.13]) (P = .02). A significant relationship was found between liver LPO and HCV recurrence, and this significance continued when accounting for pretransplantation viral load and donor age. Six patients with recurrence and 11 with no recurrence also had measurements obtained at 6 months posttransplantation. Those with recurrence at 12 months had significantly higher hepatic LPO at 6 months (1.86 [0.62]) compared with those with no recurrence (0.75 [0.14]) (P = .04).


CONCLUSIONS
Recipients of HCV livers with recurrence are more oxidatively stressed at 6 and 12 months compared with those with no recurrence. Accounting for viral load and donor age, oxidative stress was independently associated with recurrence. More research is needed to confirm this association.
Madill
J
J
Multi-Organ Transplant Department, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada. janet.madill@uhn.on.ca
Arendt
B M
BM
Aghdassi
E
E
Therapondos
G
G
Lilly
L
L
Chow
C-W
CW
Guindi
M
M
Allard
J P
JP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D001219:Aspartate Aminotransferases / Q000097:blood; D001706:Biopsy; D005260:Female; D006526:Hepatitis C / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007249:Inflammation / Q000473:pathology; D015227:Lipid Peroxidation; D008103:Liver Cirrhosis / Q000473:pathology; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D018977:Micronutrients / Q000378:metabolism; D008875:Middle Aged; D009336:Necrosis; D018384:Oxidative Stress; D018579:Patient Selection; D012008:Recurrence; D019562:Viral Load
D000975:Antioxidants; D018977:Micronutrients; D001219:Aspartate Aminotransferases