title: Merging nucleophilic and hydrogen bonding catalysis: an anion binding approach to the kinetic resolution of amines.
abstract: A new concept for asymmetric nucleophilic catalysis is presented. Acyl pyridinium salts derived from 4-(dimethylamino)pyridine (DMAP) and benzoic anhydride are rendered chiral via interaction with a chiral thiourea anion receptor. The power of this concept is demonstrated in the context of kinetic amine resolution.
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.
authors.forename: Chandra Kanta
authors.initials: CK
authors.lastname: De
authors.forename: Eric G
authors.initials: EG
authors.lastname: Klauber
authors.forename: Daniel
authors.initials: D
authors.lastname: Seidel