title: Mode of action of Van-M-02, a novel glycopeptide inhibitor of peptidoglycan synthesis, in vancomycin-resistant bacteria.
abstract: Van-M-02, a novel glycopeptide, was revealed to exert potent activities against Gram-positive bacteria, including vancomycin-resistant enterococci (VRE) and vancomycin-resistant Staphylococcus aureus (VRSA). A crude assay system was then used to study the mode of action of Van-M-02 as a peptidoglycan synthesis model of both vancomycin-susceptible and -resistant strains. The results suggested that Van-M-02 inhibits the synthesis of lipid intermediates irrespective of their termini. This inhibitory activity may contribute to the anti-VRE and anti-VRSA activities observed.
authors.affiliation: Discovery Research Laboratories, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Miura
authors.forename: Hidenori
authors.initials: H
authors.lastname: Yamashiro
authors.forename: Kouichi
authors.initials: K
authors.lastname: Uotani
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kojima
authors.forename: Takashi
authors.initials: T
authors.lastname: Yutsudo
authors.forename: Jun
authors.initials: J
authors.lastname: Lu
authors.forename: Osamu
authors.initials: O
authors.lastname: Yoshida
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Yamano
authors.forename: Hideki
authors.initials: H
authors.lastname: Maki
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Arimoto
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D016983:Enterococcus / Q000187:drug effects / Q000378:metabolism; D006020:Glycopeptides / Q000737:chemistry / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects; D015394:Molecular Structure; D010457:Peptidoglycan / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism; D020713:Vancomycin Resistance / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D010457:Peptidoglycan