Impact of cardiovascular risk factors on oxidative stress and DNA damage in a high risk Mediterranean population.
The impact of classic cardiovascular risk factors on oxidative stress status in a high-risk cardiovascular Mediterranean population of 527 subjects was estimated. Oxidative stress markers (malondialdehyde, 8-oxo-7'8'-dihydro-2'-deoxyguanosine, oxidized/reduced glutathione ratio) together with the activity of antioxidant enzyme triad (superoxide dismutase, catalase, glutathione peroxidase) were analysed in circulating mononuclear blood cells. Malondialdehyde, oxidized glutathione and the ratio of oxidized to reduced glutathione were significantly higher while catalase and glutathione peroxidase activities were significantly lower in high cardiovascular risk participants than in controls. Statistically significant differences were obtained after additional multivariate control for sex, age, obesity, diabetes, lipids and medications. Among the main cardiovascular risk factors, hypertension was the strongest determinant of oxidative stress in high risk subjects studied at a primary prevention stage.
Fandos
Marta
M
Department of Biochemistry and Molecular Biology, Faculty of Medicine, School of Medicine, University of Valencia, Valencia, Spain.
Corella
Dolores
D
Guillén
Marisa
M
Portolés
Olga
O
Carrasco
Paula
P
Iradi
Antonio
A
Martínez-González
Miguel A
MA
Estruch
Ramón
R
Covas
Maria I
MI
Lamuela-Raventós
Rosa María
RM
Michavilla
Maria Teresa
MT
Cerdá
Concha
C
Torregrosa
Rafael
R
Redón
Josep
J
Chaves
Francisco Felipe
FF
Tormos
M Carmen
MC
Ocete
Dolores
D
Sáez
Guillermo T
GT
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012307:Risk Factors; D012737:Sex Factors; D013030:Spain / Q000453:epidemiology