title: [Serotonin-noradrenalin reuptake inhibitors in the treatment of non-malignant pain syndromes; a systematic review].
abstract: BACKGROUND
  Chronic pain and depressive symptoms are often comorbid. Antidepressants seem to influence not only the symptoms of depression but also the perception of pain.
  
  
  OBJECTIVE
  To give a systematic overview of the efficacy and safety of serotonin-noradrenalin reuptake inhibitors (SNRI) in the treatment of chronic non-malignant pain syndromes.
  
  
  METHODS
  We reviewed the literature by means of PubMed and PsycInfo using combinations of the words 'pain' 'venlafaxine' and 'duloxetine'. We selected clinical studies that investigated the influence of SNRIs on pain perception.
  
  
  RESULTS
  Fourteen articles met our selection criteria. Medical conditions involved were fibromyalgia, diabetic neuropathy and post mastectomy pain. Twelve studies demonstrated the efficacy and safety of venlafaxine and duloxetine in the treatment of non-malignant pain.
  
  
  CONCLUSIONS
  The results revealed that SNRIs are effective in reducing pain particularly in the treatment of diabetic neuropathy. Results with regard to the other medical conditions are less clear. More research is needed to find out in which medical conditions SNRIs have a significant pain reducing effect and why this effect does not hold in the case of other medical conditions.
authors.affiliation: Afdeling Psychiatrie en Medische Psychologie, Maastricht Universitair Medisch Centrum, Maastricht.
authors.forename: H
authors.initials: H
authors.lastname: Vossen
authors.forename: D
authors.initials: D
authors.lastname: Monsieur
authors.forename: J
authors.initials: J
authors.lastname: van Os
authors.forename: C
authors.initials: C
authors.lastname: Leue
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000627:therapeutic use*; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D003863:Depression / Q000150:complications / Q000188:drug therapy*; D003929:Diabetic Neuropathies / Q000150:complications / Q000188:drug therapy; D005356:Fibromyalgia / Q000150:complications / Q000188:drug therapy; D006801:Humans; D010146:Pain / Q000188:drug therapy* / Q000523:psychology; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D018759:Adrenergic Uptake Inhibitors; D018687:Antidepressive Agents, Second-Generation; D017367:Selective Serotonin Reuptake Inhibitors