[Stem cell harvesting after plerixafor treatment].
A 66-year-old male with mantle cell lymphoma was treated with chemotherapy before consolidation with autologous stem cell transplantation. Despite three series of treatment with chemotherapy and stimulation with granulocyte colony-stimulating factor (filgrastim), it was not possible to mobilize hematopoietic stem cells for leukapheresis. After permission from the Danish Medicines Agency, a new stem cell factor, plerixafor, which is a direct antagonist of a surface receptor on stem cells was used. After five days of pre-treatment with filgrastim and two days of treatment with plerixafor, it was possible to harvest a sufficient number of stem cells for transplantation.
Hansen
Per Boye
PB
Medicinsk Haematologisk Afdeling L, Herlev Hospital, DK-2730 Herlev, Denmark. peboha01@heh.regionh.dk
Gaarsdal
Eva
E
D000368:Aged; D001596:Benzylamines; D057176:Compassionate Use Trials; D000080027:Cyclams; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006571:Heterocyclic Compounds / Q000008:administration & dosage*; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000628:therapy*; D008297:Male; D011994:Recombinant Proteins; D014182:Transplantation, Autologous
D001596:Benzylamines; D000080027:Cyclams; D006571:Heterocyclic Compounds; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim; C088327:plerixafor