title: Intensity-modulated radiotherapy for recurrent and second primary head and neck cancer in previously irradiated territory.
abstract: OBJECTIVE
  To evaluate re-irradiation using IMRT for recurrent and second primary head and neck cancer in previously irradiated territory.
  
  
  METHODS
  Between 1997 and 2008, 84 patients with recurrent and second primary head and neck cancer were treated with IMRT to a median dose of 69 Gy. Median time interval between initial radiotherapy and re-irradiation was 49.5 (5.2-298.3) months. Salvage surgery preceded re-irradiation in 19 patients; 17 patients received concurrent chemotherapy.
  
  
  RESULTS
  Median follow-up of living patients was 19.8 (1.9-76.1) months. Five-year locoregional control and overall survival were 40% and 20%, respectively. Five-year disease-specific survival and disease-free survival were 29% and 15%, respectively. Stage T4 (p=0.015), time interval between initial treatment and re-irradiation (p=0.011) and hypopharyngeal cancer (p=0.013) were independent prognostic factors for worse overall survival in multivariate analysis. Twenty-six and 11 patients developed Grade 3 acute and late toxicity, respectively. No Grade 5 acute toxicity was encountered. There were 2 fatal vascular ruptures during follow-up.
  
  
  CONCLUSIONS
  High-dose IMRT for recurrent and second primary head and neck cancer in previously irradiated territory leads to approximately 20% long-term survival in a non-selected patient population. Identification of patients who would benefit most of curative IMRT is warranted.
authors.affiliation: Department of Radiotherapy, Ghent University Hospital, Ghent, Belgium. frederic.duprez@ugent.be
authors.forename: Fréderic
authors.initials: F
authors.lastname: Duprez
authors.forename: Indira
authors.initials: I
authors.lastname: Madani
authors.forename: Katrien
authors.initials: K
authors.lastname: Bonte
authors.forename: Tom
authors.initials: T
authors.lastname: Boterberg
authors.forename: Luc
authors.initials: L
authors.lastname: Vakaet
authors.forename: Cristina
authors.initials: C
authors.lastname: Derie
authors.forename: Werner
authors.initials: W
authors.lastname: De Gersem
authors.forename: Wilfried
authors.initials: W
authors.lastname: De Neve
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000532:radiotherapy*; D016609:Neoplasms, Second Primary / Q000401:mortality / Q000532:radiotherapy*; D010039:Otorhinolaryngologic Neoplasms / Q000532:radiotherapy; D011832:Radiation Injuries; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated; D019233:Retreatment; D015996:Survival Rate