DDB2 (damaged-DNA binding protein 2) in nucleotide excision repair and DNA damage response.
DDB2 was identified as a protein involved in the Nucleotide Excision Repair (NER), a major DNA repair mechanism that repairs UV damage to prevent accumulation of mutations and tumorigenesis. However, recent studies indicated additional functions of DDB2 in the DNA damage response pathway. Herein, we discuss the proposed mechanisms by which DDB2 activates NER and programmed cell death upon DNA damage through its E3 ligase activity.
Stoyanova
Tanya
T
Department of Biochemistry and Molecular Genetics (M/C 669), Cancer Center, University of Illinois at Chicago, Chicago, IL, USA.
Roy
Nilotpal
N
Kopanja
Dragana
D
Raychaudhuri
Pradip
P
Bagchi
Srilata
S
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics; D004247:DNA / Q000235:genetics*; D004249:DNA Damage / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000235:genetics
C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; C117669:DDB2 protein, human; D004268:DNA-Binding Proteins; D004247:DNA; D044767:Ubiquitin-Protein Ligases; D046988:Proteasome Endopeptidase Complex