The role of glucagon-like peptide 1 in glucose homeostasis and in other aspects of human physiology.
This paper reviews the structure, function, and pathophysiology of glucagon-like peptide 1 (GLP-1). It describes the physiology and pathophysiology of the incretin axis, of which GLP-1 is a component, as well as the biosynthesis, secretion, activity, and degradation of this intestinal hormone. Effects of GLP-1 on the endocrine function of the pancreas, cardiovascular system, central nervous system, and on water-electrolyte balance have been also presented.
Franek
Edward
E
Department of Internal Diseases, Endocrinology and Diabetology, Central Clinical Hospital, Ministry of the Interior and Administration, Warszaza, Poland.
Gajos
Grzegorz
G
Gumprecht
Janusz
J
Kretowski
Adam
A
Zahorska-Markiewicz
Barbara
B
Małecki
Maciej T
MT
D000818:Animals; D002319:Cardiovascular System / Q000378:metabolism; D002490:Central Nervous System / Q000502:physiology; D005746:Gastric Emptying / Q000502:physiology; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D010179:Pancreas / Q000502:physiology; D018027:Receptors, Glucagon / Q000378:metabolism / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000502:physiology
D018027:Receptors, Glucagon; D052216:Glucagon-Like Peptide 1