title: Effects of an exercise intervention using Dance Dance Revolution on endothelial function and other risk factors in overweight children.
abstract: OBJECTIVE
  To determine whether an exercise intervention using an active video game (Dance Dance Revolution [DDR]) is effective in improving endothelial dysfunction (EDF) and other risk factors in overweight children.
  
  
  METHODS
  Thirty-five children (Body mass index > or = 85(th) percentile, mean age 10.21+/-1.67 years, 17 females) with EDF were assessed for flow-mediated dilation (FMD), lipids, insulin, glucose, NO(2)+NO(3), asymmetric dimethylarginine, symmetric dimethylarginine, l-arginine, height, weight, aerobic fitness, and blood pressure. In a subsample, tumor necrosis factor alpha, interleukin-6, C-reactive protein, and adiponectin were also assessed. Subjects were randomly assigned to 12-weeks of aerobic exercise (EX) using DDR or to a non-exercising delayed-treatment control group (DTC).
  
  
  RESULTS
  EX had significant improvements in FMD ( 5.56+/-5.04% compared with 0.263+/-4.54%, p=0.008), exercise time on the graded exercise test (53.59+/-91.54 compared with -12.83+/-68.10 seconds, p=0.025), mean arterial pressure (MAP) (-5.62+/-7.03 compared with -1.44+/-2.16 mmHg, p=0.05), weight (0.91+/-1.53 compared with 2.43+/-1.80 kg, p=0.017) and peak VO(2) (2.38+/-3.91 compared with -1.23+/-3.18 mg/kg/min, p=0.005) compared with the DTC. Thirteen EX subjects achieved normal EDF while ten did not. These groups differed at baseline with regard to total cholesterol (TC) and low-density lipoprotein (LDL).
  
  
  CONCLUSIONS
  Twelve weeks of DDR-use improved FMD, aerobic fitness, and MAP in overweight children. Improvements occurred without changes in inflammatory markers or nitric oxide production. The results document the need to explore relationships between obesity, endothelial function, inflammation, lipids, exercise intensity, and gender in a larger sample of overweight children.
authors.affiliation: Department of Pediatrics, Robert C. Byrd, Health Science Center, West Virginia University, Morgantown, West Virginia 26506-9214, USA. emurphy@hsc.wvu.edu
authors.forename: Emily C-S
authors.initials: EC
authors.lastname: Murphy
authors.forename: Linda
authors.initials: L
authors.lastname: Carson
authors.forename: William
authors.initials: W
authors.lastname: Neal
authors.forename: Christine
authors.initials: C
authors.lastname: Baylis
authors.forename: David
authors.initials: D
authors.lastname: Donley
authors.forename: Rachel
authors.initials: R
authors.lastname: Yeater
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D002648:Child; D003614:Dance Therapy; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology*; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D050177:Overweight / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D010101:Oxygen Consumption; D010349:Patient Compliance; D010809:Physical Fitness; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography; D014664:Vasodilation; D018910:Video Games
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D018836:Inflammation Mediators; D007328:Insulin; D008055:Lipids; D009566:Nitrates; D009573:Nitrites; C024917:symmetric dimethylarginine; C018524:N,N-dimethylarginine; D001120:Arginine