title: Predictors of suicidality across the life span: the Isle of Wight study.
abstract: BACKGROUND
  Data from a representative community sample were used to explore predictors of lifetime suicidality and to examine associations between distal adolescent and more proximal adult risks.
  
  
  METHODS
  Data are from a midlife follow-up of the Isle of Wight study, an epidemiological sample of adolescents assessed in 1968. Ratings of psychiatric symptoms and disorder, relationships and family functioning and adversity were made in adolescence; adult assessments included lifetime psychiatric history and suicidality, neuroticism and retrospective reports of childhood sexual abuse and harsh parenting.
  
  
  RESULTS
  A wide range of measures of childhood psychopathology, adverse experiences and interpersonal difficulties were associated with adult suicidality; associations were particularly strong for adolescent irritability, worry and depression. In multivariate analyses, substantial proportions of these effects could be explained by their association with adult psychopathology and neuroticism, but additional effects remained for adolescent irritability and worry.
  
  
  CONCLUSIONS
  Factors of importance for long-term suicidality risk are evident in adolescence. These include family and experiential adversities as well as psychopathology. In particular, markers of adolescent worry and irritability appeared both potent risks and ones with additional effects beyond associations with adult disorder and adult neuroticism.
authors: Biostatistics, Health Methodology Research Group, Faculty of Medicine and Human Sciences, University of Manchester, Manchester, UK. andrew.pickles@manchester.ac.uk
authors: A
authors: A
authors: Pickles
authors: A
authors: A
authors: Aglan
authors: S
authors: S
authors: Collishaw
authors: J
authors: J
authors: Messer
authors: M
authors: M
authors: Rutter
authors: B
authors: B
authors: Maughan
mesh_terms: D000293:Adolescent; D000328:Adult; D002650:Child Abuse, Sexual / Q000523:psychology; D003866:Depressive Disorder / Q000453:epidemiology; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D008016:Life Change Events; D016013:Likelihood Functions; D008297:Male; D016487:Parenting; D010551:Personality; D011446:Prospective Studies; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000453:epidemiology; D013405:Suicide / Q000523:psychology* / Q000706:statistics & numerical data; D013694:Temperament; D000092864:Suicide Prevention