title: [Relict microorganisms of cryolithozone as possible objects of gerontology].
abstract: Permafrost is widely distributed in the Northern Hemisphere, and its age reaches hundreds of thousands and millions of years. Permafrost contains alive microorganisms which are not frozen due to relatively high temperature of the environment (-2...-8 degrees C), but the microorganisms are immobilized and therefore aged probably similar to the age of permafrost. Longevity of the relict microbial cells is related obviously to their mechanism of protection against heat, radiation, free radicals and other damaging agents. A strain of Bacillus sp. was isolated from permafrost aged of about 3 million years, 16S rDNA sequence was identified and preliminary testing of bacterial culture on Drosophila melanogaster and mice was made. Immune stimulation and improvement of physical condition were observed, and that, together with the age of the microbial cells, presents the relict microorganisms as objects of gerontology.
authors: A V
authors: AV
authors: Brushkov
authors: V P
authors: VP
authors: Mel'nikov
authors: Iu G
authors: IuG
authors: Sukhoveĭ
authors: G I
authors: GI
authors: Griva
authors: V E
authors: VE
authors: Repin
authors: L F
authors: LF
authors: Kalenova
authors: E V
authors: EV
authors: Brenner
authors: A M
authors: AM
authors: Subbotin
authors: Iu B
authors: IuB
authors: Trofimova
authors: M
authors: M
authors: Tanaka
authors: T
authors: T
authors: Kataiama
authors: M
authors: M
authors: Utsumi
mesh_terms: D000375:Aging / Q000276:immunology* / Q000502:physiology*; D000818:Animals; D001407:Bacillus / Q000254:growth & development* / Q000302:isolation & purification / Q000502:physiology*; D003081:Cold Climate; D004269:DNA, Bacterial / Q000235:genetics; D004331:Drosophila melanogaster / Q000254:growth & development / Q000276:immunology / Q000382:microbiology; D005853:Geriatrics / Q000379:methods*; D007111:Immunity, Cellular / Q000502:physiology; D056724:Immunity, Humoral / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012800:Siberia; D012988:Soil Microbiology; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology; D013997:Time Factors
chemical_list: D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S