Hepatitis C treatment concomitant to chemotherapy as "salvage" therapy in children with hematologic malignancies.
In patients with malignancies, chronic hepatitis C reactivation or severe flare is uncommon and antiviral treatment is deferred mainly due to underlying bone marrow and immune suppression. We report the use of antiviral treatment concomitantly to chemotherapy in 3 children with hematologic malignancies, chronic hepatitis C, and significant liver dysfunction.
Papaevangelou
Vassiliki
V
Second Department of Pediatrics, University of Athens Medical School, P & A Kyriakou Children's Hospital, Goudi, Athens, Greece. vpapaev@med.uoa.gr
Varsami
Marianna
M
Papadakis
Vassilios
V
Zellos
Aglaia
A
Parcharidou
Agapi
A
Papargyri
Sophia
S
Karentzou
Ourania
O
Manolaki
Nina
N
Roma
Eleftheria
E
Polychronopoulou
Sophia
S
D000410:Alanine Transaminase / Q000097:blood; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D019337:Hematologic Neoplasms / Q000150:complications* / Q000188:drug therapy*; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D016879:Salvage Therapy / Q000379:methods*; D016896:Treatment Outcome; D019562:Viral Load
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D000410:Alanine Transaminase