title: [Choice of statistical approaches and analysis of blood serum proteome profiles in an experiment with 24-hour head-down tilt (-15 degrees)].
abstract: Variability analysis of normal human proteoma requires a valid and crisp algorithm for mass-spectrometry data analysis. The goal was to test methods of statistical analysis of blood serum proteoma profiles in an experiment with 24-hr. HDT using the small sample nonparametric criteria. The investigation revealed peaks that appear to be a molecular response of organism to simulated microgravity. Further identification of fiducially mobile peaks with the help of tandem mass-spectrometry will enable disclosure of subtle mechanisms of adaptation to the spaceflight factors and improvement of human health evaluation in space missions of varying length.
authors: N A
authors: NA
authors: Pakharukova
authors: A M
authors: AM
authors: Nosovskiĭ
authors: L Kh
authors: LKh
authors: Pastushkova
authors: O P
authors: OP
authors: Trifonova
authors: I M
authors: IM
authors: Larina
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D002940:Circadian Rhythm / Q000502:physiology*; D005500:Follow-Up Studies; D018475:Head-Down Tilt / Q000502:physiology*; D006801:Humans; D015233:Models, Statistical; D020543:Proteome / Q000502:physiology*; D044967:Serum / Q000502:physiology*; D055815:Young Adult
chemical_list: D001798:Blood Proteins; D020543:Proteome