Nickel-catalyzed highly chemo-, regio-, and stereoselective three-component reaction of norbornene with two alkynes.
The first three-component reaction of norbornene with two alkynes leading to 1,5-enyne via C-H bond activation of terminal silylacetylene was achieved using a Ni(cod)(2)/phosphine catalyst. This reaction is applicable for various internal alkynes and norbornene derivatives with high regio- and stereoselectivities.
Ogata
Kenichi
K
Department of Applied Chemistry, Institute of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan. kogata@kc.chuo-u.ac.jp
Sugasawa
Jun
J
Atsuumi
Yuka
Y
Fukuzawa
Shin-ichi
S