title: Fertility after uterine artery embolization: investigation using a sheep model.
abstract: OBJECTIVE
  To investigate the influence of uterine artery embolization (UAE) on fertility after bilateral UAE with either tris-acryl gelatin microspheres (TAGM) or gelatin particles (GP).
  
  
  METHODS
  Six ewes that underwent UAE with TAGM, 6 ewes that underwent UAE with GP, and 6 control ewes were compared. After hormonal synchronization of the menstrual cycle, artificial insemination (AI) was performed. When pregnancy did not result, ewes were naturally inseminated.
  
  
  RESULTS
  After AI, progesterone concentrations in blood increased and were maintained at >1.0 ng/mL in 9 ewes (3 per group). Three ewes became pregnant after AI. The abortion rate was higher in the UAE group. The remaining 15 sheep were naturally inseminated, with 14 delivering 15 lambs. Mean period of term gestation in UAE group ewes was 155.7 versus 158.6 days in control group ewes. Lambs' body weight, body length, and withers height after birth did not differ between those from UAE group and control group. Lambs from ewes embolized with GP tended to be smaller and had lower body weight than those from other groups.
  
  
  CONCLUSIONS
  Uterine artery embolization influenced reproductive ability in sheep and UAE with GP could lead to intrauterine growth retardation.
authors: Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo, Kyoto, Japan. yamagami@koto.kpu-m.ac.jp
authors: Takuji
authors: T
authors: Yamagami
authors: Rika
authors: R
authors: Yoshimatsu
authors: Tomohiro
authors: T
authors: Matsumoto
authors: Hiroshi
authors: H
authors: Anzai
authors: Masahiro
authors: M
authors: Yoshizawa
authors: Yutaka
authors: Y
authors: Fukui
authors: Tsunehiko
authors: T
authors: Nishimura
mesh_terms: D000180:Acrylic Resins / Q000008:administration & dosage; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000209:etiology*; D005780:Gelatin / Q000008:administration & dosage; D007247:Infertility, Female / Q000097:blood / Q000209:etiology*; D011247:Pregnancy; D012756:Sheep; D055357:Uterine Artery Embolization / Q000009:adverse effects*
chemical_list: D000180:Acrylic Resins; C496735:trisacryl gelatin microspheres; D005780:Gelatin