title: Serum chitotriosidase activity and Wegener's granulomatosis.
abstract: OBJECTIVE
  We evaluated serum chitotriosidase activity in patients with Wegener's granulomatosis (WG) and compared the values to controls.
  
  
  METHODS
  We used a standard fluorometric assay to measure chitotriosidase enzyme activity.
  
  
  RESULTS
  Serum chitotriosidase enzyme activity levels were higher in WG patients. We found no association between clinical disease activity and chitotriosidase enzyme activity.
  
  
  CONCLUSIONS
  Serum chitotriosidase enzyme activity has limited utility as a biomarker in WG patients.
authors: Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Center for Vasculitis Care and Research, Cleveland, OH, USA. Curry.Koening@hsc.utah.edu
authors: Curry L
authors: CL
authors: Koening
authors: Carmen E
authors: CE
authors: Gota
authors: Carol A
authors: CA
authors: Langford
authors: Gary S
authors: GS
authors: Hoffman
authors: Marvin R
authors: MR
authors: Natowicz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000097:blood* / Q000201:enzymology*; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D006596:Hexosaminidases; C086400:chitotriosidase