Dynamic model inversion techniques for breath-by-breath measurement of carbon dioxide from low bandwidth sensors.
Respiratory CO(2) measurement (capnography) is an important diagnosis tool that lacks inexpensive and wearable sensors. This paper develops techniques to enable use of inexpensive but slow CO(2) sensors for breath-by-breath tracking of CO(2) concentration. This is achieved by mathematically modeling the dynamic response and using model-inversion techniques to predict input CO(2) concentration from the slow-varying output. Experiments are designed to identify model-dynamics and extract relevant model-parameters for a solidstate room monitoring CO(2) sensor. A second-order model that accounts for flow through the sensor's filter and casing is found to be accurate in describing the sensor's slow response. The resulting estimate is compared with a standard-of-care respiratory CO(2) analyzer and shown to effectively track variation in breath-by-breath CO(2) concentration. This methodology is potentially useful for measuring fast-varying inputs to any slow sensor.
Sivaramakrishnan
Shyam
S
University of Minnesota, Twin Cities, MN 55455, USA. shyams@me.umn.edu
Rajamani
Rajesh
R
Johnson
Bruce D
BD
D000465:Algorithms; D001944:Breath Tests / Q000379:methods; D019296:Capnography / Q000295:instrumentation* / Q000379:methods*; D002245:Carbon Dioxide / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods; D004867:Equipment Design; D006801:Humans; D015233:Models, Statistical; D008962:Models, Theoretical; D008991:Monitoring, Physiologic / Q000379:methods; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors
D002245:Carbon Dioxide