Compartmental analysis and its manifold applications to pharmacokinetics.
In this paper, I show how the concept of compartment evolved from the simple dilution of a substance in a physiological volume to its distribution in a network of interconnected spaces. The differential equations describing the fate of a substance in a living being can be solved, qualitatively and quantitatively, with the help of a number of mathematical techniques. A number of parameters of pharmacokinetic interest can be computed from the experimental data; often, the data available are not sufficient to determine some parameters, but it is possible to determine their range.
Rescigno
Aldo
A
rescigno@mac.com
D000818:Animals; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D010599:Pharmacokinetics