Subchronic toxicity of cannabis leaves on male albino rats.
Cannabis is the most commonly abused drug in the world. In Egypt, the Anti Narcotic General Administration showed that the narcotics problem costs the Egyptian economy approximately 800 million dollars annually. LD(50), lethal dose that kills 50% of the treated animals, of the bango was determined and then selected groups of rats were given tenth of LD(50) for 90 days. The histopathological effects were determined. All the studied organs were affected markedly in the form of shrunken cells in brain. The liver cells were affected in the form of rarefaction of the cytoplasm, kidneys were with severe congestion. The testicles were with disruption of the spermatogenic cells from the membrane.
Yassa
Heba A
HA
Department of Forensic Medicine and Clinical Toxicology, Assiut University, Egypt. heba_amgad_5@hotmail.com
Dawood
Abd El Wahab A
Ael W
Shehata
Manal M
MM
Abdel-Hady
Randa H
RH
Aal
Khaled M Abdel
KM
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D002188:Cannabis / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000473:pathology*; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000633:toxicity*; D018515:Plant Leaves; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000187:drug effects / Q000473:pathology
D010936:Plant Extracts