title: Intracranial volumes in a large series of healthy children.
abstract: BACKGROUND
  Craniosynostosis alters the normal growth of the infant skull and can influence intracranial pressure and intracranial volume. The purpose of this study was to measure intracranial volumes in a large series of healthy children to serve as a reference for further studies exploring the impact of craniosynostosis and vault remodeling on intracranial growth.
  
  
  METHODS
  A total of 123 children were included in this study from a retrospective review of pediatric emergency room visits for evaluation of head trauma where a head computed tomography scan was performed. Intracranial volumes were obtained using a semiautomated image segmentation technique and volume-rendering software.
  
  
  RESULTS
  Volume measurements were obtained and plotted against age, and a best fit curve approximation was derived. In this study of healthy children, intracranial volume doubled by 9 months of age and tripled by 6 years of age.
  
  
  CONCLUSIONS
  This large study contributes to the existing data demonstrating intracranial volumes in healthy children up to 6 years of age. These data can be used by clinicians as a reference in the assessment of a child presenting with cranial dysmorphology.
authors: New York, N.Y. From the Division of Plastic Surgery, Department of Surgery, New York Presbyterian Hospital, Columbia University College of Physicians and Surgeons, and Weill Cornell Medical College.
authors: Mehul R
authors: MR
authors: Kamdar
authors: R Alex
authors: RA
authors: Gomez
authors: Jeffrey A
authors: JA
authors: Ascherman
mesh_terms: D000367:Age Factors; D001921:Brain / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000254:growth & development*; D016022:Case-Control Studies; D002508:Cephalometry; D002648:Child; D002675:Child, Preschool; D003393:Cranial Sutures / Q000000981:diagnostic imaging / Q000254:growth & development; D003398:Craniosynostoses / Q000000981:diagnostic imaging* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D021621:Imaging, Three-Dimensional; D007223:Infant; D007231:Infant, Newborn; D007427:Intracranial Pressure / Q000502:physiology; D008297:Male; D009929:Organ Size / Q000502:physiology; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D012737:Sex Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*