[Study on sugarcane alkane alcohol to quail hyperlipidemia and atherosclerosis model].
OBJECTIVE
To study on pharmacologic actions on quail hyperlipidemia and atherosclerosis model.


METHODS
To duplicate quail hyperlipidemia model by ectogenesis cholesterol and high fat forage, induce to atherosclerosis model, observe influence of sugarcane alkane alcohol to model animals' blood fat level, formation of atherosclerosis plaque, pathological changes of coronary vessels and vascular intimal.


RESULTS
TC, TG, LDL-C level in blood serum of quail hyperlipidemia markedly decreased after administered sugarcane alkane alcohol by dose of 30, 15, 7.5 mg x kg(-1), proliferation of aorta and brachiocephalic artery tunica intima foam cells was suppressed.


CONCLUSIONS
Sugarcane alkane alcohol has satisfactory pharmacologic actions on hyperlipidemia and atherosclerosis animal model by regulating blood fat.
Shi
Zhongfeng
Z
Guangdong Pharmaceutical University, Center Laboratory, Guangzhou 510006, China. shizhf@139.com
Yan
Qixin
Q
Zhao
Jinhua
J
Yao
Guanghui
G
D000473:Alkanes / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy*; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D000431:Ethanol / Q000737:chemistry / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000188:drug therapy*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use; D011784:Quail; D011897:Random Allocation; D031786:Saccharum / Q000737:chemistry*
D000473:Alkanes; D010936:Plant Extracts; D000431:Ethanol; D002784:Cholesterol