title: [Concentration of serum leptin and age in Chinese women and comparison with other races].
abstract: OBJECTIVE
  To determine the relationship between concentration of serum leptin and age in females, and to establish the reference value and compare it with other races.
  
  
  METHODS
  Serum leptin concentration of 690 adult healthy women (aged 20 approximately 81 years) was measured with ELISA.
  
  
  RESULTS
  The serum leptin concentration increased with age (r=0.224, P<0.001), and cubic regression was the best-fitting model. Leptin concentration had significant positive correlation with weight (r=0.574) and body mass index (r=0.618). The geometric mean of leptin concentration in normal weight, overweight and obesity was (8.94+/-1.82), (17.6+/-1.89), and (34.7+/-1.69) microg/L, respectively, with significant difference among the 3 groups (P<0.001). Leptin in pre-menopause, peri-menopause and post-menopause women was (9.68+/-1.81), (11.7+/-1.89), and (11.4+/-2.21) microg/L, respectively. The reference value of serum leptin in normal weight females was 5.30 approximately 12.6 microg/L. The curve-fitting of leptin with age in this group was significantly lower than American non Hispanic White (NHW), non Hispanic Black (NHB), and American Mexican (AM) females.
  
  
  CONCLUSIONS
  This study provides reliable reference value of serum leptin in adult women and discovers ethnic difference with American NHW, NHB, and AM females.
authors: Institute of Endocrinology and Metabolism, Central South University, Changsha 410011, China.
authors: Rong
authors: R
authors: Zhang
authors: Eryuan
authors: E
authors: Liao
authors: Xianping
authors: X
authors: Wu
authors: Hui
authors: H
authors: Xie
authors: Pengfei
authors: P
authors: Shan
authors: Hong
authors: H
authors: Zhang
authors: Xianghang
authors: X
authors: Luo
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002681:China / Q000208:ethnology; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D012016:Reference Values; D044465:White People; D055815:Young Adult
chemical_list: D020738:Leptin