title: Cytologic regression in women with atypical squamous cells of unknown significance and negative human papillomavirus test.
abstract: OBJECTIVE
  The aim of this study was to investigate the cytologic regression in women with atypical squamous cells of unknown significance and negative high-risk human papillomavirus test.
  
  
  METHODS
  The 45 women with atypical squamous cells of unknown significance and negative high-risk human papillomavirus at baseline were analyzed about the cytologic regression during 2 years of follow-up. The cumulative rate of cytologic regression was calculated by Kaplan-Meier curves.
  
  
  RESULTS
  Of 45 women, the cumulative rates were as follows: 55.6% obtained cytologic regression before 6 months, 84.4% by 1 year, and 95.6% at 2 years. Cytologic regression was not influenced by age, menopausal status, and baseline human papillomavirus load. However, the 1-year cumulative regression rate in women with previous cervical lesions was significantly lower than those without (P=.02), even much lower in women with high-grade intraepithelial neoplasia or worse (P=.008).
  
  
  CONCLUSIONS
  Most women with atypical squamous cells of unknown significance and negative high-risk human papillomavirus could obtain cytologic regression within 2 years. Women with antecedent cervical lesions need longer time to reach this regression.
authors: Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, People's Republic of China.
authors: Shu
authors: S
authors: Wang
authors: Jing He
authors: JH
authors: Lang
authors: Xue Mei
authors: XM
authors: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D052685:Alphapapillomavirus; D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000175:diagnosis*; D011230:Precancerous Conditions / Q000473:pathology*; D012075:Remission, Spontaneous; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014626:Vaginal Smears; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000473:pathology*