title: Development of a multispectral tissue characterization system for optimization of an implantable perfusion status monitor for transplanted liver.
abstract: Optimizing wavelength selection for monitoring perfusion during liver transplant requires an in-depth characterization of liver optical properties. With these, the impact of liver absorption and scattering properties can be investigated to select optimal wavelengths for perfusion monitoring. To accomplish this, we are developing a single integrating-sphere-based technique using a unique spatially resolved diffuse reflectance system for multispectral optical properties determination for thick samples. We report early results using a monochromatic source to measure the optical properties of well characterized tissue phantoms made from polystyrene spheres and Trypan blue. The presented results demonstrate the feasibility of using this unique system to measure optical properties of tissue phantoms. We are currently in the process of implementing an automated Levenberg-Marquardt diffuse-reflectance-profile fitting algorithm to enable near realtime robust computation of sample optical properties. Future work will focus on the incorporation of multispectral capability to provide needed data to facilitate development of more realistic liver tissue phantoms.
authors: Measurement Science & Systems Engineering Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA. babajs@ornl.gov
authors: J S
authors: JS
authors: Baba
authors: B S
authors: BS
authors: Letzen
authors: M N
authors: MN
authors: Ericson
authors: G L
authors: GL
authors: Cote
authors: W
authors: W
authors: Xu
authors: M A
authors: MA
authors: Wilson
mesh_terms: D000818:Animals; D004058:Diffusion; D006454:Hemoglobins / Q000378:metabolism; D008099:Liver / Q000000981:diagnostic imaging; D016031:Liver Transplantation / Q000295:instrumentation* / Q000379:methods*; D051379:Mice; D055620:Optical Phenomena; D010100:Oxygen / Q000378:metabolism; D010477:Perfusion; D019736:Prostheses and Implants; D014057:Tomography, X-Ray Computed
chemical_list: D006454:Hemoglobins; D010100:Oxygen