Serum chitotriosidase activity and Wegener's granulomatosis.
OBJECTIVE
We evaluated serum chitotriosidase activity in patients with Wegener's granulomatosis (WG) and compared the values to controls.


METHODS
We used a standard fluorometric assay to measure chitotriosidase enzyme activity.


RESULTS
Serum chitotriosidase enzyme activity levels were higher in WG patients. We found no association between clinical disease activity and chitotriosidase enzyme activity.


CONCLUSIONS
Serum chitotriosidase enzyme activity has limited utility as a biomarker in WG patients.
Koening
Curry L
CL
Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Center for Vasculitis Care and Research, Cleveland, OH, USA. Curry.Koening@hsc.utah.edu
Gota
Carmen E
CE
Langford
Carol A
CA
Hoffman
Gary S
GS
Natowicz
Marvin R
MR
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000097:blood* / Q000201:enzymology*; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D006596:Hexosaminidases; C086400:chitotriosidase