title: Biomarkers identification and detection based on GMR sensor and sub 13 nm magnetic nanoparticles.
abstract: In this paper, we present a ultra high sensitive (Zeptomole, 10(-21)) technique to enable the detection of any potential low abundance biomarkers. We demonstrated for the first time the detection of sub 13nm high-moment magnetic nanoparticle and the implementation of a novel magnetoresistive (GMR) biosensor concept with higher sensitivity and 10 times lower external field in real biomarker sensing schemes. A potential lung cancer biomarker, interleukin-6 (IL-6), was successfully detected with extremely low concentration (as few as only 200 pieces of IL-6). Together with other features of GMR sensor systems like low-cost, portability, easy-to-use, our demonstrated device may lead to future family-based personalized medicine for cancer prevention.
authors: Department of Electrical and Computer Engineering, Minneapolis, MN 55455, USA.
authors: Yuanpeng
authors: Y
authors: Li
authors: Ying
authors: Y
authors: Jing
authors: Xiaofeng
authors: X
authors: Yao
authors: Balasubramanian
authors: B
authors: Srinivasan
authors: Yunhao
authors: Y
authors: Xu
authors: Chengguo
authors: C
authors: Xing
authors: Jian-Ping
authors: JP
authors: Wang
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D015374:Biosensing Techniques / Q000295:instrumentation*; D017097:Electric Impedance; D008280:Magnetics / Q000295:instrumentation*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D019809:Streptavidin / Q000737:chemistry
chemical_list: D015415:Biomarkers; D019809:Streptavidin