title: Endosulfan increases seric interleukin-2 like (IL-2L) factor and immunoglobulin M (IgM) of Nile tilapia (Oreochromis niloticus) challenged with Aeromona hydrophila.
abstract: Endosulfan is a persistent organochlorine insecticide which is extremely toxic to fish. It is known to induce immunological alterations in juvenile Nile tilapia (Oreochromis niloticus) such as increases in phagocytic activity and reactive oxygen species production of spleen macrophages. The purpose of the present study was to demonstrate the effects of acute exposure to a sublethal concentration of endosulfan (7 ppb, 96 h) on parameters of the adaptive humoral immune response of the aforementioned aquatic organism. The effect of endosulfan on the capacity of immune cells to produce interleukin-2 like (IL-2L) factor and immunoglobulin M (IgM) in response to a challenge with (1/2) LD50 of the infectious bacteria Aeromonas hydrophila was evaluated. Experimental results indicate that short, sublethal, endosulfan exposure triggers a succession of events beginning with non-specific activation of macrophages followed by an exacerbated synthesis of the IL-2L factor by activated B cells. This leads to significantly increased secretion of IgM and could in turn facilitate autoantibody production and the development of autoimmune pathologies.
authors: Departamento de Biología Celular y Molecular, Universidad de Guadalajara, Carretera a Nogales Km 15.5, z.p. 45110, Las Agujas, Zapopan, Jalisco, Mexico.
authors: Martha Cecilia
authors: MC
authors: Tellez-Bañuelos
authors: Anne
authors: A
authors: Santerre
authors: Josefina
authors: J
authors: Casas-Solis
authors: Galina
authors: G
authors: Zaitseva
mesh_terms: D016980:Aeromonas hydrophila / Q000276:immunology; D000818:Animals; D023681:Cichlids / Q000276:immunology*; D004726:Endosulfan / Q000633:toxicity*; D005786:Gene Expression Regulation / Q000187:drug effects*; D016905:Gram-Negative Bacterial Infections / Q000276:immunology*; D056724:Immunity, Humoral / Q000187:drug effects*; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology*; D007306:Insecticides / Q000633:toxicity; D007376:Interleukin-2 / Q000097:blood / Q000276:immunology*; D008297:Male; D014874:Water Pollutants, Chemical / Q000633:toxicity
chemical_list: D007075:Immunoglobulin M; D007306:Insecticides; D007376:Interleukin-2; D014874:Water Pollutants, Chemical; D004726:Endosulfan