title: Adenovirus-derived vectors for prostate cancer gene therapy.
abstract: Prostate cancer is a leading cause of death among men in Western countries. Whereas the survival rate approaches 100% for patients with localized cancer, the results of treatment in patients with metastasized prostate cancer at diagnosis are much less successful. The patients are usually presented with a variety of treatment options, but therapeutic interventions in prostate cancer are associated with frequent adverse side effects. Gene therapy and oncolytic virus therapy may constitute new strategies. Already a wide variety of preclinical studies has demonstrated the therapeutic potential of such approaches, with oncolytic prostate-specific adenoviruses as the most prominent vector. The state of the art and future prospects of gene therapy in prostate cancer are reviewed, with a focus on adenoviral vectors. We summarize advances in adenovirus technology for prostate cancer treatment and highlight areas where further developments are necessary.
authors: Department of Molecular Cell Biology, Leiden University Medical Center , 2300 RC Leiden, The Netherlands.
authors: Jeroen
authors: J
authors: de Vrij
authors: Ralph A
authors: RA
authors: Willemsen
authors: Leif
authors: L
authors: Lindholm
authors: Rob C
authors: RC
authors: Hoeben
authors: Chris H
authors: CH
authors: Bangma
authors: Chris
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authors: Barber
authors: Jean-Paul
authors: JP
authors: Behr
authors: Simon
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authors: Briggs
authors: Robert
authors: R
authors: Carlisle
authors: Wing-Shing
authors: WS
authors: Cheng
authors: Iris J C
authors: IJ
authors: Dautzenberg
authors: Corrina
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authors: de Ridder
authors: Helena
authors: H
authors: Dzojic
authors: Patrick
authors: P
authors: Erbacher
authors: Magnus
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authors: Essand
authors: Kerry
authors: K
authors: Fisher
authors: April
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authors: Frazier
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authors: LJ
authors: Georgopoulos
authors: Ian
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authors: Jennings
authors: Stefan
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authors: Kochanek
authors: Daniela
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authors: Koppers-Lalic
authors: Robert
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authors: Kraaij
authors: Florian
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authors: Kreppel
authors: Maria
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authors: Magnusson
authors: Norman
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authors: Maitland
authors: Patrick
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authors: Neuberg
authors: Regina
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authors: Nugent
authors: Manfred
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authors: Ogris
authors: Jean-Serge
authors: JS
authors: Remy
authors: Michelle
authors: M
authors: Scaife
authors: Ellen
authors: E
authors: Schenk-Braat
authors: Erik
authors: E
authors: Schooten
authors: Len
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authors: Seymour
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authors: Slade
authors: Pio
authors: P
authors: Szyjanowicz
authors: Thomas
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authors: Totterman
authors: Taco G
authors: TG
authors: Uil
authors: Karel
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authors: Ulbrich
authors: Laura
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authors: van der Weel
authors: Wytske
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authors: van Weerden
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authors: Wagner
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authors: Zuber
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D015316:Genetic Therapy / Q000379:methods / Q000639:trends; D005822:Genetic Vectors / Q000235:genetics*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000628:therapy*