The need for large-scale randomized evidence without undue emphasis on small trials, meta-analyses, or subgroup analyses.
Hennekens
Charles H
CH
Department of Clinical Science and Medical Education, Charles E. Schmidt College of Biomedical Science and Center of Excellence, Florida Atlantic University, Boca Raton, FL 33431, USA. chenneke@fau.edu
Demets
David
D
D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D003627:Data Interpretation, Statistical; D003657:Decision Making; D019317:Evidence-Based Medicine; D006291:Health Policy; D006801:Humans; D015201:Meta-Analysis as Topic; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment