Implantable MEMS drug delivery pumps for small animal research.
Advanced devices capable of selective delivery of compounds to targeted tissues are lacking, especially in small animal research. Biomedical microelectromechanical systems (bioMEMS) are uniquely suited to this application through the combination of scalability and precise control of fluid handling. Polymer-based drug delivery components and pumps for acute and chronic delivery in small animals are discussed.
Meng
Ellis
E
Departments of Biomedical and Electrical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089-1111, USA. ellis.meng@ usc.edu
Li
Po-Ying
PY
Lo
Ronalee
R
Sheybani
Roya
R
Gutierrez
Christian
C
D000818:Animals; D035843:Biomedical Research / Q000295:instrumentation*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004572:Electrolysis; D015918:Infusion Pumps, Implantable; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D011817:Rabbits; D012212:Rheology; D013696:Temperature