title: The unexpected link between osteoclasts and the immune system.
abstract: Osteoimmunology is an interdisciplinary research field focused on the molecular understanding of the interplay of the skeletal and immune systems. In particular, the interaction between immune cells and osteoclasts is a current major topic of critical interest in this field. The macrophage-osteoclast interaction has long been studied, and the T-cellosteoclast interaction also attracted much attention in the study of arthritis. However, recent reports have revealed a hitherto unknown link between osteoclasts and other immune cells, including B cells and dendritic cells, suggesting a larger number of molecules are in fact shared by osteoclasts and immune cells. These findings will lead to a better understanding of the pathogenesis of diseases affecting both systems and may/will provide a molecular basis for novel therapeutic strategies.
authors: Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan. taka.csi@tmd.ac.jp
authors: Hiroshi
authors: H
authors: Takayanagi
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000201:enzymology; D056657:Cathepsin K / Q000378:metabolism; D003713:Dendritic Cells / Q000166:cytology / Q000201:enzymology; D006801:Humans; D007107:Immune System / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D010010:Osteoclasts / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D053245:RANK Ligand / Q000378:metabolism; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D053245:RANK Ligand; C089848:Tec protein-tyrosine kinase; D011505:Protein-Tyrosine Kinases; D056657:Cathepsin K