Combined photoacoustic and magneto-acoustic imaging.
Ultrasound is a widely used modality with excellent spatial resolution, low cost, portability, reliability and safety. In clinical practice and in the biomedical field, molecular ultrasound-based imaging techniques are desired to visualize tissue pathologies, such as cancer. In this paper, we present an advanced imaging technique - combined photoacoustic and magneto-acoustic imaging - capable of visualizing the anatomical, functional and biomechanical properties of tissues or organs. The experiments to test the combined imaging technique were performed using dual, nanoparticle-based contrast agents that exhibit the desired optical and magnetic properties. The results of our study demonstrate the feasibility of the combined photoacoustic and magneto-acoustic imaging that takes the advantages of each imaging techniques and provides high sensitivity, reliable contrast and good penetrating depth. Therefore, the developed imaging technique can be used in wide range of biomedical and clinical application.
Qu
Min
M
Ultrasound Imaging and Therapeutics Research Laboratory in the Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712-0238, USA. qumin@mail.utexas.edu
Mallidi
Srivalleesha
S
Mehrmohammadi
Mohammad
M
Ma
Li Leo
LL
Johnston
Keith P
KP
Sokolov
Konstantin
K
Emelianov
Stanislav
S
D003952:Diagnostic Imaging / Q000295:instrumentation* / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry; D008280:Magnetics; D033401:Microscopy, Acoustic / Q000295:instrumentation* / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry; D055095:Optics and Photonics / Q000295:instrumentation* / Q000379:methods*
D005290:Ferric Compounds; C000499:ferric oxide