title: Possible acute and chronic synergistic effect of dual chamber pacing and disopyramide in obstructive hypertrophic cardiomyopathy: a case report.
abstract: It remains unclear whether the combination of dual-chamber (DDD) pacing and disopyramide can achieve prolonged left ventricular outflow tract (LVOT) gradient reduction and symptom relief in patients with obstructive hypertrophic cardiomyopathy (HCM). In an HCM patient with a severe LVOT gradient, the combination of DDD pacing and disopyramide achieved marked improvement of gradient in the catheter laboratory and also after medium-term follow-up. The patient's severe dyspnoea was alleviated during the follow-up period. This combination might enable physicians to treat and manage elderly symptomatic obstructive HCM patients with a severe LVOT gradient more effectively and less invasively.
authors: Department of Cardiology, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
authors: Shintaro
authors: S
authors: Haruki
authors: Yuichiro
authors: Y
authors: Minami
authors: Katsuya
authors: K
authors: Kajimoto
authors: Bun
authors: B
authors: Yashiro
authors: Tsuyoshi
authors: T
authors: Suzuki
authors: Masatoshi
authors: M
authors: Kawana
authors: Nobuhisa
authors: N
authors: Hagiwara
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000628:therapy*; D003131:Combined Modality Therapy; D004206:Disopyramide / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016896:Treatment Outcome; D014463:Ultrasonography; D014694:Ventricular Outflow Obstruction / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*
chemical_list: D000889:Anti-Arrhythmia Agents; D004206:Disopyramide