In vitro antitubercular and antimicrobial activities of 1-substituted quinoxaline-2,3(1H,4H)-diones.
1-((Substituted)methyl)quinoxaline-2,3(1H,4H)-dione (2a-e) and 1-((substituted)acryloyl)quinoxaline-2,3(1H,4H)-dione (4a-c) were synthesized from quinoxaline-2,3(1H,4H)-dione 1 and evaluated for their antimicrobial activities. Results of the antitubercular screening against Mycobacterium tuberculosis H(37)Rv showed that the compounds 2b,3, and 4a were the most effective, with minimum inhibitory concentrations of 8.012, 8.561, and 8.928microg/ml, respectively. All the compounds exhibited significant antibacterial and considerable antifungal activities.
Ramalingam
P
P
Raghavendra Institute of Pharmaceutical Education and Research, Anantapur, Andhra Pradesh 515 721, India. rammpharm@rediffmail.com
Ganapaty
S
S
Rao
Ch Babu
ChB
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011810:Quinoxalines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D011810:Quinoxalines