[Protective effect of Galla chinensis apozema on adriamycin-induced nephropathy in rats].
OBJECTIVE
To study the protective effect of Galla chinensis apozema on adriamycin-induced nephropathy in rats and its mechanism.


METHODS
40 Wistar rats were randomly divided into four groups: normal control group, model group, Galla chinensis apozema high dose group and Galla chinensis apozema low dose group. Adriamycin-induced nephropathy model was built by injecting adriamycin through the tail vein. The high and low dose groups of Galla chinensis apozema were given Galla chinensis apozema for 6 weeks, the other two groups were given normal saline in the same way. Then we observed the 24 h urine protein at each weekend, and determined blood biochemical indexes, SOD and MDA at the last weekend.


RESULTS
Galla chinensis decreased urine protein excretion, but increased total cholesterol and triglyceride in plasma, total protein and albumin in serum of model rats. Galla chinensis also decreased the serum levels of MDA but increased the activity of SOD.


CONCLUSIONS
Galla chinensis can protect against adriamycin-induced nephrototoxicity. Its mechanism possibly associated with the reduction of oxidative stress.
Zeng
Wen-Yi
WY
Pharmaceutical preparation Section of Dongguan People Hospital, Dongguan 523018, China.
Chen
Li
L
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008517:Phytotherapy; D011507:Proteinuria / Q000652:urine; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood
D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D004317:Doxorubicin; D013482:Superoxide Dismutase