Risk of spontaneous miscarriage in euthyroid women with thyroid autoimmunity undergoing IVF: a meta-analysis.
OBJECTIVE
To investigate whether thyroid autoimmunity (TAI) is associated with increased risk for spontaneous miscarriage in subfertile, euthyroid women undergoing IVF.


METHODS
Meta-analysis of observational studies.


METHODS
Four prospective studies that reported data on 1098 subfertile women undergoing IVF (141 with TAI and 957 controls) were included in the meta-analysis.


METHODS
Miscarriage risk ratio (RR).


METHODS
Clinical pregnancy rate and delivery rate.


RESULTS
Euthyroid, subfertile women with TAI undergoing IVF demonstrated significantly higher risk for miscarriage compared with controls (four studies-fixed effects RR: 1.99, 95% confidence interval: 1.42- 2.79, P<0.001). No significant difference in clinical pregnancy and delivery rates was detected between groups.


CONCLUSIONS
Based on the currently available evidence, it appears that the presence of TAI is associated with an increased risk for spontaneous miscarriage in subfertile women achieving a pregnancy through an IVF procedure.
Toulis
Konstantinos A
KA
Unit of Reproductive Endocrinology Unit for Human Reproduction, First Department of Obstetrics and Gynecology, Medical School, Papageorgiou General Hospital, Aristotle University, Ring Road, Nea Efkarpia, 56403 Thessaloniki, Greece. toulis@endo.gr
Goulis
Dimitrios G
DG
Venetis
Christos A
CA
Kolibianakis
Efstratios M
EM
Negro
Roberto
R
Tarlatzis
Basil C
BC
Papadimas
Ioannis
I
D000022:Abortion, Spontaneous / Q000097:blood / Q000209:etiology* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D013961:Thyroid Gland / Q000276:immunology*
D001323:Autoantibodies