Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors.
A series of imidazopyrimidine derivatives with the general formula I was synthesized and identified as potent inhibitors of iNOS dimer formation, a prerequisite for proper functioning of the enzyme. Stille and Negishi coupling reactions were used as key steps to form the carbon-carbon bond connecting the imidazopyrimidine core to the central cycloalkenyl, cycloalkyl and phenyl ring templates.
Chu
Guo-Hua
GH
Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.
Le Bourdonnec
Bertrand
B
Gu
Minghua
M
Ajello
Christopher W
CW
Leister
Lara K
LK
Sellitto
Ian
I
Cassel
Joel A
JA
Tuthill
Paul A
PA
O' Hare
Heather
H
Dehaven
Robert N
RN
Dolle
Roland E
RE