[A case of HIV coinfected with hepatitis B virus treated by entecavir].
A 45-year-old male active homosexual was given a diagnosis of HIV-1 and acute hepatitis B in August 2007. Since his liver function became rapidly impaired, anti-HBV therapy with oral administration of entecavir (ETV) was started, and resulted in a favorable outcome. However, serum concentration of HIV-RNA decreased by log 1.26 within 60 days, which strongly suggested the inhibition of HIV proliferation by ETV. To prevent the appearance of mutated HIV, novel therapeutic strategies should be established in HIV/HBV-coinfected patients.
Yamada
Akihiro
A
Division of Gastroenterology, Toyama Hospital, International Medical Center of Japan, Japan. akihiyamada-gi@umin.ac.jp
Sako
Akahito
A
Nishimura
So
S
Nakashima
Ryo
R
Ogami
Toshiko
T
Fujiya
Keiichi
K
Tsuda
Naonori
N
Asayama
Naoki
N
Yada
Tomoyuki
T
Shirai
Kiyokazu
K
Akazawa
Naoki
N
Sakurai
Toshiyuki
T
Yago
Yuzo
Y
Nagata
Naoyoshi
N
Oshima
Takao
T
Yokoi
Chizu
C
Sasajima
Keita
K
Kobayakawa
Masao
M
Akiyama
Junichi
J
Imamura
Masatoshi
M
Yanase
Mikio
M
Uemura
Naomi
N
Masaki
Naohiko
N
D000998:Antiviral Agents / Q000627:therapeutic use*; D006147:Guanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006509:Hepatitis B / Q000188:drug therapy*; D006716:Homosexuality; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis*
D000998:Antiviral Agents; D012367:RNA, Viral; C413685:entecavir; D006147:Guanine