A case of atopic dermatitis-associated lichen amyloidosis successfully treated with oral cyclosporine and narrow band UVB therapy in succession.
Lichen amyloidosis (LA) is a chronic, severely pruritic skin disease characterized by deposition of amyloid in the skin with no visceral involvement. Current treatments of LA are unsatisfactory, with high relapse rates, complications, and treatment failures. A 31-year-old woman with a history of refractory atopic dermatitis (AD) presented with pruritic, multiple, discrete papules on the extremities and back. Histopathologic examination confirmed the diagnosis of LA. A treatment regimen of oral cyclosporine and subsequent narrow band UVB (NBUVB) for a total of 8 months resulted in nearly complete regression. Although further studies are required to define the exact mechanism of action of this treatment regimen (oral cyclosporine + NBUVB), it seems to be an effective alternative in treating patients with LA and/or AD-associated LA.
Kang
Min Ju
MJ
Department of Dermatology, Kangnam St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kim
Hei Sung
HS
Kim
Hyung Ok
HO
Park
Young Min
YM
D000284:Administration, Oral; D000328:Adult; D000686:Amyloidosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome; D014467:Ultraviolet Therapy
D003879:Dermatologic Agents; D016572:Cyclosporine