title: [Experimental study on cytochrome P450 enzymes after receiving ferment powder caterpillar fungus].
abstract: OBJECTIVE
  To study the effect of ferment powder caterpillar fungus on cytochrome P450 isozymes CYP1A2, CYP3A4 and CYP2E1.
  
  
  METHODS
  The methods of Cocktail probe drugs were used. The rats were randomly divided into two groups. One group were given ferment powder caterpillar fungus once daily orally for ten days. Another group received orally normal saline one daily as the blank control. After ten days of treatment, the rats were given probe drugs of coffine, dapsone and chlorzoxazone and the blood was taken out by femoral catheterization. The plasma concentration of probe drugs were determined by HPLC. Data of plasma drug level-time were disposed with DAS Ver 2.0.
  
  
  RESULTS
  The metabolism of caffeine and dapsone speeded up after receiving ferment powder caterpillar fungus, but the metabolism of chlorzoxazone was hardly changed.
  
  
  CONCLUSIONS
  It suggested that ferment powder caterpillar fungus tended to be the inducer of CYP1A2 and CYP3A4. But the CYP2E1 was hardly affected.
authors: The People's Hospital of Gansu Province, Lanzhou 730000, China.
authors: Hai
authors: H
authors: Jia
authors: Aixia
authors: A
authors: Xu
authors: Jiyong
authors: J
authors: Yuan
authors: Xiang
authors: X
authors: Gao
authors: Jun
authors: J
authors: Gao
mesh_terms: D000818:Animals; D002110:Caffeine / Q000378:metabolism; D002753:Chlorzoxazone / Q000378:metabolism; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003622:Dapsone / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005285:Fermentation; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D065607:Cytochrome P-450 Enzyme Inhibitors; D004365:Drugs, Chinese Herbal; D002110:Caffeine; D003622:Dapsone; D003577:Cytochrome P-450 Enzyme System; D002753:Chlorzoxazone