Apoptolidins E and F, new glycosylated macrolactones isolated from Nocardiopsis sp.
Two new glycosylated macrolactones, apoptolidins E (5) and F (6), were isolated from fermentation of the actinomycete Nocardiopsis sp. and their structures assigned. Lacking the C16 and C20 oxygens of apoptolidin A (1), these macrolides are also the first members of this family to display a 4-O-methyl-l-rhamnose at C9 rather than a 6-deoxy-4-O-methyl-l-glucose.
Wender
Paul A
PA
Department of Chemistry and Department of Chemical and Systems Biology, Stanford University, Stanford, California 94305-5080, USA. wenderp@stanford.edu
Longcore
Kate E
KE
D039903:Actinobacteria / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005947:Glucose / Q000737:chemistry; D006031:Glycosylation; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure
D018942:Macrolides; C546481:apoptolidin E; C546482:apoptolidin F; D005947:Glucose