title: An "aggressive" protocol of programmed ventricular stimulation for selecting post-myocardial infarction patients with a low ejection fraction who may not require implantation of an automatic defibrillator.
abstract: BACKGROUND
  The predictive value of electrophysiologic studies depends on the aggressiveness of the programmed ventricular stimulation protocol.
  
  
  OBJECTIVE
  To assess if non-inducibility with an "aggressive" protocol of PVS identifies post-infarction patients with low ejection fraction (EF < or = 30%) who may safely be treated without implantable cardioverter defibrillator.
  
  
  METHODS
  We studied 154 patients during a 9 year period. Our aggressive PVS protocol included: a) stimulus current five times the diastolic threshold (< or = 3 mA) and b) repetition of double and triple extrastimulation at the shortest coupling intervals that capture the ventricle.
  
  
  RESULTS
  Sustained ventricular tachyarrhythmias were induced in 116 patients (75.4%) and 112 (97%) of them received an ICD (EPS+/ICD+ group). Of the 38 non-inducible patients, 34 (89.5%) did not receive an ICD (EPS-/ICD-group). In comparison to the EPS+/ICD+ group, EPS-/ICD-group patients were older (69 +/- 10 vs. 65 +/- 10 years, P < 0.05), had a lower EF (23 +/- 5% vs. 25 +/- 5%, P < 0.05) and a higher prevalence of left bundle branch block (45.5% vs. 20.2%, P < 0.005). Follow-up was longer for EPS+/ICD+ patients (40 +/- 26 months) than for EPS-/ICD- patients (27 +/- 22 months) (P = 0.011). Twelve EPS+/ICD+ patients (10.7%) and 5 EPS-/ICD-patients (14.7%) died during follow-up (P = 0.525). Kaplan-Meier survival curves did not show a significant difference between the two groups (P = 0.18).
  
  
  CONCLUSIONS
  The mortality rate in patients without inducible VTAs using an aggressive PVS protocol and who did not undergo subsequent ICD implantation is not different from that of patients with inducible arrhythmias who received an ICD. Using this protocol, as many as one-fourth of primary prevention ICD implants could be spared without compromising patient prognosis.
authors: Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. bblhass@tasmc.health.gov.il
authors: Bernard
authors: B
authors: Belhassen
authors: Tamar
authors: T
authors: Ohayon-Tsioni
authors: Aharon
authors: A
authors: Glick
authors: Sami
authors: S
authors: Viskin
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D054849:Cardiac Electrophysiology; D003627:Data Interpretation, Statistical; D017147:Defibrillators, Implantable; D015716:Electrocardiography, Ambulatory; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*; D018579:Patient Selection; D018709:Statistics, Nonparametric; D013318:Stroke Volume; D017180:Tachycardia, Ventricular / Q000503:physiopathology* / Q000628:therapy; D013997:Time Factors