Bioactive components and pharmacological action of Wikstroemia indica (L.) C. A. Mey and its clinical application.
Wikstroemia indica (L.) C. A. Mey. is a member of family Thymelaeaceae and mainly distributes in middle and southeast part of China. As a traditional Chinese herb, this plant has long been employed as antipyretics, detoxicants, expectorants, vermifuges as well as aborticides in clinic practice. However, its use has mainly been based on empirical findings during hundreds and thousands of years. Recent studies indicated that W. indica contains abundant active components including flavonoids, biflavonoids, coumarins, lignans, volatile oils, polysaccharides etc. This paper provides a comprehensive review of pharmacological relevant compounds of W. indica that have been characterized to date, and introduce the research progresses supporting its pharmacological action and clinical application. Particular attention has been given to antibacterial, antiviral, anti-inflammatory, anti-tumor and antifertility effects. Some examples of clinical applications of prepared W. indica in treatment of various diseases are outlined. Finally, the trend and necessity of future research, such as quantification of individual constituents extracted from W. indica and the assessment of their pharmacological activities in human body are proposed.
Li
Yan-Min
YM
College of Food and Bioengineering, South China University of Technology, Guangzhou, 510640, China.
Zhu
Liang
L
Jiang
Jian-Guo
JG
Yang
Li
L
Wang
Ding-Yong
DY
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D032365:Wikstroemia / Q000737:chemistry*
D004365:Drugs, Chinese Herbal