title: HTR2A is associated with SSRI response in major depressive disorder in a Japanese cohort.
abstract: Several recent investigations reported that the serotonin 2A receptor gene (HTR2A) was associated with selective serotonin reuptake inhibitors (SSRIs) in major depressive disorder. There have also been two reported association analyses of HTR2A with SSRI response in Japanese MDD patients, but the results were rather inconsistent and both studies had the problem of small sample sizes. Therefore, we conducted a replication association study using a sample larger than those in the two original Japanese studies (265 MDD patients), and found that four SNPs, two functional SNPs (-A1438G: rs6311 and T102C: rs6313) and two SNPs (rs7997012 and rs1928040) in HTR2A, were associated with the therapeutic response to SSRIs. HTR2A was associated with the therapeutic response SSRIs in Japanese MDD patients in a haplotype-wise analysis (P(all markers) = 0.0136), and a significant association between rs1928040 in HTR2A and SSRI response was detected in MDD (P(allele-wise analysis) = 0.0252). However, this significance disappeared after Bonferroni correction (P(allele-wise analysis) = 0.101). In conclusion, we suggest that HTR2A may play an important role in the pathophysiology of the therapeutic response to SSRIs in Japanese MDD patients. However, it will be important to replicate and confirm these findings in other independent studies using large samples.
authors: Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. tarok@fujita-hu.ac.jp
authors: Taro
authors: T
authors: Kishi
authors: Reiji
authors: R
authors: Yoshimura
authors: Tsuyoshi
authors: T
authors: Kitajima
authors: Tomo
authors: T
authors: Okochi
authors: Takenori
authors: T
authors: Okumura
authors: Tomoko
authors: T
authors: Tsunoka
authors: Yoshio
authors: Y
authors: Yamanouchi
authors: Yoko
authors: Y
authors: Kinoshita
authors: Kunihiro
authors: K
authors: Kawashima
authors: Hiroshi
authors: H
authors: Naitoh
authors: Jun
authors: J
authors: Nakamura
authors: Norio
authors: N
authors: Ozaki
authors: Nakao
authors: N
authors: Iwata
mesh_terms: D044466:Asian People / Q000235:genetics*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics*; D016666:Fluvoxamine / Q000627:therapeutic use; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D017374:Paroxetine / Q000627:therapeutic use; D020641:Polymorphism, Single Nucleotide; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D016666:Fluvoxamine; D017374:Paroxetine; D044402:Receptor, Serotonin, 5-HT2A; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline