Attenuation of carbon tetrachloride-induced hepatotoxicity by cow urine distillate in rats.
OBJECTIVE
To study the carbon tetrachloride-induced hepatoprotective activity in cow urine.


METHODS
Effect of cow urine distillate on liver function was studied in vivo in rats intoxicated with carbon tetrachloride (CCl4). Hepatotoxicity was induced by a 1:1 (v/v) mixture of CCl4 in olive oil (5 mL/kg i.p). Protective effect of cow urine distillate (in three dose levels) and standard drug Silymarin (100 mg/kg, p.o) on liver function were studied in intoxicated rats. Parameters in the study included liver function tests and histological observations.


RESULTS
The cow urine distillate decreased the levels of SGOT, SGPT, ALP, GGT, and total bilirubin in a dose-dependent manner (P < 0.05) as sylimarin.


CONCLUSIONS
The observed protective effects of cow urine distillate on liver function might be due to the presence of antioxidants in cow urine.
Gururaja
M P
MP
Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences, Paneer Deralakatte Mangalore-574160, India. gurureceptor@rediffmail.com
Joshi
A B
AB
Joshi
Himanshu
H
Sathyanarayana
D
D
Subrahmanyam
E V S
EV
Chandrashekhar
K S
KS
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002417:Cattle; D022781:Hepatocytes / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012838:Silymarin / Q000494:pharmacology; D014556:Urine
D012838:Silymarin; D002251:Carbon Tetrachloride