Discovery of ectoparasiticidal hydrazonotrifluoromethanesulfonanilides.
A series of hydrazonotrifluorosulfonanilide derivatives were synthesized and evaluated for in vitro activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. Some compounds with excellent activity against tick were identified.
Ali
Abdelselam
A
CSIRO Molecular and Health Technologies, Bag 10, Clayton South, Vic 3169, Australia.
Fisara
Petr
P
Freemont
Jamie A
JA
Kyi
Stella
S
Meyer
Adam G
AG
Riches
Andrew G
AG
Sargent
Roger M
RM
Sawutz
David G
DG
Turner
Kathleen A
KA
Winzenberg
Kevin N
KN
Yang
Qi
Q
D000818:Animals; D000977:Antiparasitic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002415:Cats; D004285:Dogs; D055808:Drug Discovery; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D048508:Rhipicephalus sanguineus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D000977:Antiparasitic Agents; D006835:Hydrazones; D013449:Sulfonamides; C032898:trifluoromethanesulfonanilide