title: Sex-related differences in cisplatin-induced neuropathy in rats.
abstract: BACKGROUND
  Cisplatin is used as an anti-neoplastic agent against several cancers. Neuropathy is one of its major side effects that contributes to patients' intolerance to the standard regimen. Sex-related differences have been reported in nerve injury and neuropathies. However, there has been no study on cisplatin regarding this issue.
  
  
  OBJECTIVE
  Compare various abnormalities in cisplatin neuropathy between sexes.
  
  
  METHODS
  Two mg/kg of cisplatin was administered intraperitoneally twice a week for five consecutive weeks. Body weight, heat latency of hind paw and sciatic motor nerve conduction velocity (MNCV), pathological alterations in the sciatic nerve and dorsal root ganglion (DRG) including the level of NGF in the sciatic nerve were examined. Untreated rats of both sexes were used as controls.
  
  
  RESULTS
  Weight loss, prolonged heat latency, and slow MNCV in the treated rats of both sexes with higher severity in males were showed. Furthermore, reduction in myelinated fiber diameter, myelin thickness, and myelinated fiber density was more severe in females, whereas, atrophy of neuronal cell body, nucleus, and nucleolus was more striking in males. The decreased level of NGF was similar between sexes.
  
  
  CONCLUSIONS
  These data suggest the differences in various aspects of cisplatin neurotoxicity between sexes. However, future studies are needed to verify this issue in a clinical condition and clarify the underlying mechanisms.
authors: Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors: Tulaporn
authors: T
authors: Wongtawatchai
authors: Sithiporn
authors: S
authors: Agthong
authors: Atitaya
authors: A
authors: Kaewsema
authors: Vilai
authors: V
authors: Chentanez
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002945:Cisplatin / Q000633:toxicity*; D005260:Female; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D011115:Polyneuropathies / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D015431:Weight Loss / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin