title: Novel antibiotic-eluting wound dressings: an in vitro study and engineering aspects in the dressing's design.
abstract: Wound dressings aim to restore the milieu required for skin regeneration by protecting the wound from environmental threats, including penetration of bacteria, and by maintaining a moist healing environment. A wide variety of wound dressing products targeting various types of wounds and different aspects of the wound healing process are currently available on the market. Ideally, a dressing should be easy to apply and remove, and its design should meet both physical and mechanical requirements; namely water absorbance and transmission rate, handleability and strength. In this article, our novel biodegradable antibiotic-eluting wound dressings are described and the engineering aspects in the design are emphasized. These unique new wound dressings are based on a polyglyconate mesh, coated with a porous Poly(dl-lactic-co-glycolic acid) matrix. They demonstrated excellent mechanical and physical properties and desired release profiles of antibiotic drugs which enable bacterial inhibition. Hence, a new generation of wound dressings is now emerging with clear benefits. These include better protection against infection and reducing the need for frequent dressing changing.
authors: Dept. of Biomedical Engineering, Faculty of Engineering, Tel-Aviv University, Tel-Aviv 69978, Israel.
authors: Jonathan J
authors: JJ
authors: Elsner
authors: Meital
authors: M
authors: Zilberman
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002442:Ceftazidime / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D004867:Equipment Design; D005260:Female; D006801:Humans; D008422:Materials Testing; D055595:Mechanical Phenomena; D009779:Occlusive Dressings; D011108:Polymers; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D011108:Polymers; C046409:polyglyconate; D002442:Ceftazidime