title: Carbonated soft drinks and carbonyl stress burden.
abstract: Carbonated soft drinks reportedly contain methylglyoxal (MG), which is strongly associated with human carbonyl stress. We sought to evaluate the effects of carbonated drink intake on human carbonyl stress. We measured MG levels in 4 commercial beverage brands, and evaluated the changes in plasma MG in healthy subjects following the intake of carbonated drinks. By 30 min after intake of samples containing high glucose and high MG, the levels of plasma MG, glucose, insulin and uric acid had increased significantly, and then returned to basal levels by 120 min. After intake of the low-calorie carbonated samples containing little MG, there were no increases in plasma MG. Our results suggest that glucose-containing carbonated soft drinks are associated with increases in not only glucose but also carbonyl burden.
authors: Keisuke
authors: K
authors: Nakayama
authors: Masaaki
authors: M
authors: Nakayama
authors: Hiroyuki
authors: H
authors: Terawaki
authors: Yaeko
authors: Y
authors: Murata
authors: Toshinobu
authors: T
authors: Sato
authors: Masahiro
authors: M
authors: Kohno
authors: Sadayoshi
authors: S
authors: Ito
mesh_terms: D000328:Adult; D001786:Blood Glucose; D002253:Carbonated Beverages / Q000009:adverse effects* / Q000032:analysis; D004435:Eating; D005247:Feeding Behavior; D006801:Humans; D007328:Insulin / Q000097:blood*; D008875:Middle Aged; D011765:Pyruvaldehyde / Q000032:analysis / Q000097:blood*; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014527:Uric Acid; D011765:Pyruvaldehyde