title: Analysis of prognostic factors in patients with gastric varices after endoscopic treatment.
abstract: BACKGROUND
  The prognostic factors, including gastric variceal bleeding itself, in patients with gastric varices (GV) after endoscopic treatment remain unclear. The aim of this study was to analyze prognostic factors in patients with GV after endoscopic treatment as well as to evaluate safety and efficacy of our endoscopic treatment.
  
  
  METHODS
  This study enrolled 115 patients who underwent endoscopic treatment for GV between October 1988 and December 2003 using cyanoacrylate and 5% ethanolamine oleate. Successful hemostasis, recurrence rates, rebleeding rates, survival rates, complications and prognostic factors after the treatment were retrospectively reviewed.
  
  
  RESULTS
  Treatment sessions for GV were performed 3.4 +/- 2.5 times. All cases, including 14 emergency cases, were treated successfully. The cumulative recurrence rates at 1, 3 and 5 years after the treatment were 7.0%, 15.6% and 20.0%, respectively, and the cumulative rebleeding rates at 1, 3 and 5 years were 3.5%, 8.7% and 14.8%, respectively. The overall survival rates were 78.3%, 63.7% and 51.5% at 1, 3 and 5 years, respectively. Grade B or C in Child-Pugh classification, emergency or elective cases, and association with hepatocellular carcinoma were identified as significant negative prognostic factors after endoscopic treatment by multivariate analysis. Although several complications were observed, there was no mortality.
  
  
  CONCLUSIONS
  Grade B or C in Child-Pugh classification, emergency or elective situation, and association with hepatocellular carcinoma are negative prognostic factors after endoscopic treatment.
authors: Department of Internal Medicine 2, Fukushima Medical University School of Medicine, Fukushima Medical University Hospital, Fukushima City, Fukushima, Japan. wakachan@fmu.ac.jp
authors: Takeru
authors: T
authors: Wakatsuki
authors: Katsutoshi
authors: K
authors: Obara
authors: Atsushi
authors: A
authors: Irisawa
authors: Hiroaki
authors: H
authors: Sakamoto
authors: Toshimitu
authors: T
authors: Kuwana
authors: Fujio
authors: F
authors: Takiguchi
authors: Ayako
authors: A
authors: Saito
authors: Hideo
authors: H
authors: Shishido
authors: Takuto
authors: T
authors: Hikichi
authors: Hitoshi
authors: H
authors: Oyama
authors: Goro
authors: G
authors: Shibukawa
authors: Tadayuki
authors: T
authors: Takagi
authors: Go
authors: G
authors: Yamamoto
authors: Hidemichi
authors: H
authors: Imamura
authors: Yuta
authors: Y
authors: Takahashi
authors: Ai
authors: A
authors: Sato
authors: Masaki
authors: M
authors: Sato
authors: Reiji
authors: R
authors: Kasukawa
authors: Hiromasa
authors: H
authors: Ohira
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003487:Cyanoacrylates / Q000008:administration & dosage*; D004724:Endoscopy; D004932:Esophageal and Gastric Varices / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009829:Oleic Acids / Q000008:administration & dosage*; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D012597:Sclerosing Solutions / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D003487:Cyanoacrylates; D009829:Oleic Acids; D012597:Sclerosing Solutions; C033343:ethanolamine oleate