Chronic dietary kudzu isoflavones improve components of metabolic syndrome in stroke-prone spontaneously hypertensive rats.
The present study tested the long-term effects of dietary kudzu root extract supplementation on the regulation of arterial pressure, plasma glucose, and circulating cholesterol in stroke-prone spontaneously hypertensive rats (SP-SHR). Female SP-SHR were maintained for 2 months on a polyphenol-free diet, with or without the addition of 0.2% kudzu root extract. Half of the rats in each diet group were ovariectomized, whereas the other half remained intact. Following 2 months on the diets, the 0.2% kudzu root extract supplementation (compared to control diet) significantly lowered arterial pressure (11-15 mmHg), plasma cholesterol, fasting blood glucose (20-30%), and fasting plasma insulin in both the ovariectomized and intact SP-SHR. These results indicate that long-term dietary kudzu root extract supplementation can improve glucose, lipid, and blood pressure control in intact and ovariectomized SP-SHR.
Peng
Ning
N
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0006, USA.
Prasain
Jeevan K
JK
Dai
Yanying
Y
Moore
Ray
R
Arabshahi
Alireza
A
Barnes
Stephen
S
Carlson
Scott
S
Wyss
J Michael
JM
D000818:Animals; D001786:Blood Glucose; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000627:therapeutic use*; D024821:Metabolic Syndrome / Q000178:diet therapy* / Q000378:metabolism* / Q000503:physiopathology; D010936:Plant Extracts / Q000627:therapeutic use*; D029908:Pueraria / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D020521:Stroke / Q000178:diet therapy / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*
D001786:Blood Glucose; D007529:Isoflavones; D010936:Plant Extracts; D002784:Cholesterol