[Severe hypercalcemia complicated in acute lymphoblastic leukemia (ALL) with E2A-HLF fusion gene: report of two cases and literature review].
OBJECTIVE
To improve the understanding of severe hypercalcemia complicated in acute lymphoblastic leukemia (ALL) with E2A-HLF fusion gene, and to explore the mechanism of pathogenesis and the relationship between the special gene translocation and severe hypercalcemia.


METHODS
Two patients with severe hypercalcemia complicated in ALL were reported.


RESULTS
Two patients with E2A-HLF fusion gene, which is generated by t(17;19) (q22, p13) translocation, suffered relapse of leukemia three months after chemotherapy, and developed severe hypercalcemia. After further chemotherapy, the hypercalcemia symptoms were corrected or alleviated.


CONCLUSIONS
Severe hypercalcemia is one of rare complications of ALL. In B cell lymphoblastic leukemia with E2A-HLF fusion gene, the fusion gene showed be closely monitored for evaluating the disease situation.
Yang
Jun
J
The Hematology Center of Beijing Children Hospital, Capital Medical University, Beijing 100045, China.
Zhou
Xuan
X
Wang
Bin
B
Gao
Chao
C
Zhang
Rui-dong
RD
Li
Bin
B
D002648:Child; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology* / Q000235:genetics; D007223:Infant; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000235:genetics*; D011379:Prognosis; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; C076554:E2a-Hlf fusion protein, human; D015514:Oncogene Proteins, Fusion; D014157:Transcription Factors