title: Endocervical adenocarcinoma in situ with ovarian metastases: a unique variant with potential for long-term survival.
abstract: Adenocarcinoma in situ (AIS) of the endocervix is typically confined to the cervix, but may be extensive. We report 2 cases of extensive AIS-one with intraendometrial spread-that recurred after cone biopsy and were associated with ovarian metastases. In both cases, primary and metastatic tumors were positive for human papillomavirus 16. Both patients are currently disease-free and one has had no recurrence after a follow-up period of 145 months. Extensive, recurring AIS is a rare variant that may be unique for its risk of coincident ovarian involvement. However, ovarian spread, albeit rare, does not invariably result in an adverse outcome.
authors: Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
authors: Martin C
authors: MC
authors: Chang
authors: Nicole S
authors: NS
authors: Nevadunsky
authors: Akila N
authors: AN
authors: Viswanathan
authors: Christopher P
authors: CP
authors: Crum
authors: Colleen M
authors: CM
authors: Feltmate
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000556:secondary* / Q000821:virology; D000328:Adult; D002278:Carcinoma in Situ / Q000401:mortality / Q000473:pathology* / Q000821:virology; D005260:Female; D052162:Human papillomavirus 16; D006801:Humans; D010051:Ovarian Neoplasms / Q000401:mortality / Q000556:secondary* / Q000821:virology; D030361:Papillomavirus Infections / Q000150:complications; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology* / Q000821:virology