title: Total peroxynitrite scavenging capacity of phenylethanoid and flavonoid glycosides from the flowers of Buddleja officinalis.
abstract: Nine compounds, including six phenylethanoid glycosides: acteoside (1); bioside (2); echinacoside (3); poliumoside (4); phenylethyl glycoside (5); salidroside (6) and three flavonoids; linarin (7); apigenin (8); isorhoifolin (9), were isolated from the flowers of Buddleja officinalis MAXIM. (Buddlejaceae). Chemical structures were confirmed by (1)H-, and (13)C-NMR, and MS spectral methods and compared with those reported in the literature. Antioxidant activities of the methanol and water extracts, and all isolated compounds were evaluated using the total oxidant scavenging capacity (TOSC) assay against peroxynitrite. Results of the assay showed that the phenylethanoid glycosides, a major class of compounds of the flowers of B. officinalis, possess strong antioxidant activity. Of these, acteoside, echinacoside and poliumoside have 9.9-, 9.8- and 9.5-fold TOSC value, respectively, compared with the positive control, Trolox.
authors: Institute of Natural Products Chemistry, VAST.
authors: Bui Huu
authors: BH
authors: Tai
authors: Bong Yong
authors: BY
authors: Jung
authors: Nguyen Manh
authors: NM
authors: Cuong
authors: Pham Thuy
authors: PT
authors: Linh
authors: Nguyen Huu
authors: NH
authors: Tung
authors: Nguyen Xuan
authors: NX
authors: Nhiem
authors: Tran Thu
authors: TT
authors: Huong
authors: Ngo Thi
authors: NT
authors: Anh
authors: Jeong Ah
authors: JA
authors: Kim
authors: Sang Kyum
authors: SK
authors: Kim
authors: Young Ho
authors: YH
authors: Kim
mesh_terms: D032861:Buddleja / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D035264:Flowers; D016166:Free Radical Scavengers / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D030421:Peroxynitrous Acid; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D005419:Flavonoids; D016166:Free Radical Scavengers; D006027:Glycosides; D010636:Phenols; D010936:Plant Extracts; D030421:Peroxynitrous Acid