title: In vivo bone response and mechanical evaluation of electrosprayed CaP nanoparticle coatings using the iliac crest of goats as an implantation model.
abstract: Recent trends in clinical implantology include the use of endosseous dental implant surfaces embellished with nano-sized modifications. The current study was initiated to evaluate the mechanical properties, as well as the potential beneficial effects, of electrosprayed CaP nanoparticle-coated (nano-CaP) implants on the in vivo osteogenic response, compared with grit-blasted, acid-etched (GAE) implant surfaces as controls. For this purpose nano-CaP coatings were deposited on cylindrical screw-type (St) implants and implanted bilaterally into the iliac crest of goats for 6weeks. In addition to histological and histomorphometrical analyses, insertion torque and removal torque values were measured on implant placement and retrieval, respectively. The present study showed similar insertion and removal torque values for nano-CaP-coated and GAE control implants, with no statistically significant increase in torque value during the implant period for either group. With regard to bone-implant contact and peri-implant bone volume, no significant differences were found between nano-CaP-coated and GAE implants after 6weeks implantation. In conclusion, this study has demonstrated that in situations in which implants are placed in a non-compromised situation using a standard press fit implantation strategy the performance of electrosprayed nano-CaP coatings is comparable with GAE implants, both with respect to implant fixation and bone healing response.
authors: Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors: Corinne
authors: C
authors: Schouten
authors: Gert J
authors: GJ
authors: Meijer
authors: Jeroen J J P
authors: JJ
authors: van den Beucken
authors: Sander C G
authors: SC
authors: Leeuwenburgh
authors: Lise T
authors: LT
authors: de Jonge
authors: Joop G C
authors: JG
authors: Wolke
authors: Paul H M
authors: PH
authors: Spauwen
authors: John A
authors: JA
authors: Jansen
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D055119:Elastic Modulus; D004563:Electrochemistry / Q000379:methods; D005260:Female; D006041:Goats; D006244:Hardness; D007085:Ilium / Q000473:pathology* / Q000601:surgery*; D008422:Materials Testing; D013314:Stress, Mechanical; D013499:Surface Properties
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; C020243:calcium phosphate