title: Incidence of histological prostatitis and its correlation with PSA density.
abstract: OBJECTIVE
  The aim of this study was to determine the incidence of asymptomatic, histologically proven prostatitis in men with symptoms of benign prostate hyperplasia and to observe the correlation between asymptomatic prostatitis and prostate specific antigen (PSA) density.
  
  
  BACKGROUND
  The incidence of type IV prostatitis is unknown. There is a tendency to correlate the presence of inflammatory prostatitis with an elevation of PSA.
  
  
  METHODS
  From August 2000 to January 2006, 183 patients who underwent surgical treatment for benign prostate hyperplasia as a result of obstructive or irritative symptoms were prospectively studied. In accordance with the histology findings, these patients were divided into two groups: group I included patients with the presence of histological prostatitis and group II included patients with the absence of histological prostatitis. The mean PSA densities were compared.
  
  
  RESULTS
  Histological evidence of prostatitis was observed in 145 patients. In this group, the mean PSA density was 0.136 +/- 0.095. In 38 cases, there was no evidence of inflammation upon histological examination of the surgical samples. In these 38 cases, the mean PSA density was 0.126 +/- 0.129. No statistically significant differences were detected between the two groups; the p-value is 0.124.
  
  
  CONCLUSIONS
  Abnormal PSA density should not be attributed to the inflammatory prostatitis process.
authors: Department of Urology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - São Paulo/SP, Brazil.
authors: Affonso Celso
authors: AC
authors: Piovesan
authors: Geraldo de Campos
authors: Gde C
authors: Freire
authors: Fabio César Miranda
authors: FC
authors: Torricelli
authors: Paulo
authors: P
authors: Cordeiro
authors: Renato
authors: R
authors: Yamada
authors: Miguel
authors: M
authors: Srougi
mesh_terms: D000368:Aged; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011470:Prostatic Hyperplasia / Q000473:pathology* / Q000601:surgery; D011472:Prostatitis / Q000453:epidemiology* / Q000378:metabolism
chemical_list: D017430:Prostate-Specific Antigen