Vascular tone and the genomics of hypertension.
Hypertension is a common condition that is a well-described risk factor for the development of cerebrovascular disease, myocardial infarction and heart failure. Medical therapy for hypertension may not only prevent development of these potentially devastating illnesses but may be used to treat high blood pressure, which coexists with these conditions. Therapeutic response to medical therapy for hypertension is variable and may be related to the individual genetic profile of patients. We have described here only several of the HTN-related polymorphisms that may impact clinical response in patients who have high blood pressure and coexisting conditions. Future studies are needed to identify other potential genotypes that may influence therapeutic response in addition to clinical trials of specific medical therapy in individual patients based on specific genotypes.
Sheppard
Richard
R
Heart Function Clinic, Jewish General Hospital, McGill University, 377 Cote St Catherine Road, Montreal, Quebec H3T 1E2, Canada. richard.sheppard@mcgill.ca
D000659:AMP Deaminase / Q000235:genetics; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002864:Chromogranins; D016232:Endothelins / Q000235:genetics / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000235:genetics; D019204:GTP-Binding Proteins / Q000187:drug effects / Q000235:genetics; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics; D009569:Nitric Oxide / Q000096:biosynthesis / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011942:Receptors, Adrenergic, alpha / Q000235:genetics / Q000502:physiology; D012039:Regional Blood Flow / Q000187:drug effects; D012307:Risk Factors; D015398:Signal Transduction / Q000235:genetics; D014664:Vasodilation / Q000187:drug effects
D000959:Antihypertensive Agents; D002864:Chromogranins; D016232:Endothelins; C454420:G-protein beta3 subunit; D011942:Receptors, Adrenergic, alpha; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D000659:AMP Deaminase; C406732:GNAS protein, human; D019204:GTP-Binding Proteins; D019205:GTP-Binding Protein alpha Subunits, Gs; D020962:Heterotrimeric GTP-Binding Proteins