Matrix metalloproteinase-9 promoter gene polymorphism (-1562C>T) in nasal polyposis.
BACKGROUND
Expression of matrix metalloproteinase (MMP)-9 increases in nasal polyp tissues. However, the impact of MMP-9 genotypes on the development of nasal polyposis (NP) is unknown. The aim of this study was to examine a potential association of MMP-9 promoter gene polymorphism with the development of NP.


METHODS
A prospective and case-control study was performed on 93 patients with NP and 115 controls without sinonasal disease. Genotypes of MMP-9 (-1562C>T) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.


RESULTS
The frequency of -1562CT genotype of MMP-9 was significantly high in NP patients with aspirin-induced asthma (p = 0.014). Distribution of T allele was significantly high in NP patients with aspirin-induced asthma (p = 0.013). MMP-9 genotypes were not associated with gender or the presence of atopy.


CONCLUSIONS
In this study, MMP-9 -1562CT genotype was associated with susceptibility to NP in aspirin-induced asthmatic patients. Because this report is a population-based study, further research should be performed on larger study subjects to reveal the precise role of MMP-9 promoter gene polymorphism in the development of NP.
Erbek
Selim S
SS
Department of Otolaryngology, Baskent University, Faculty of Medicine, Ankara, Turkey. selimerbek@gmail.com
Yurtcu
Erkan
E
Erbek
Seyra
S
Sahin
Feride I
FI
D000328:Adult; D055963:Asthma, Aspirin-Induced / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics* / Q000276:immunology / Q000378:metabolism*; D008875:Middle Aged; D009298:Nasal Polyps / Q000235:genetics / Q000276:immunology / Q000473:pathology; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D011446:Prospective Studies
D020780:Matrix Metalloproteinase 9