[The expression and significance of immunity associated genes mRNA in patients with pulmonary embolism].
OBJECTIVE
To investigate the molecular alteration of immunity associated genes in patients with pulmonary embolism (PE) so as to preliminarily elucidate its pathogenetic mechanism.


METHODS
Human cDNA microarray analysis was employed in this study, random variance model (RVM) corrected t-test was used for the statistical data analysis of differential gene expression.


RESULTS
In comparison with control, mRNA expression of functional genes of neutrophils, monophagocytes, IFN regulating factors, TNF, adhesion molecules and T cells were significantly different in PE patients. However, gene expressions of B cell immune function and complement activation associated factors were not significantly different between two groups.


CONCLUSIONS
Unbalance expression of immune function associated genes, especially down-regulated expression of T cell mediated function genes, in patients with PE indicates that the etiology of PE might be related to viral infection.
Gong
Zhu
Z
Hospital of Tongji University, Shanghai 200065, China.
Liang
Ai-Bin
AB
Wang
Le-Min
LM
Zhang
Xiao-Yu
XY
Wang
Qiang
Q
Huang
Chun-Yu
CY
Song
Hao-Ming
HM
Wang
Hao
H
Shen
Yu-Qin
YQ
Gao
Heng-Jun
HJ
Shen
Xiao-Ying
XY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015536:Down-Regulation; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007694:Killer Cells, Natural; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D011655:Pulmonary Embolism / Q000235:genetics* / Q000276:immunology*; D012333:RNA, Messenger / Q000235:genetics; D016176:T-Lymphocyte Subsets
D012333:RNA, Messenger