title: Iodine-125-fibrinogen kinetics in the rabbit arterial wall.
abstract: Elevated fibrinogen has been claimed as an independent risk factor for the development of atherosclerosis. Incorporation of fibrinogen into human atherosclerotic lesions has been demonstrated. We assessed in a rabbit model of experimental atherosclerosis, biodistribution as well as kinetics and vascular uptake of (125)I-fibrinogen. Rabbits aged 6 months were fed a 1% cholesterol supplemented diet. After experimental de-endothelialization of rabbit aorta using a Fogarthy catheter, (125)I-fibrinogen uptake was enhanced by more than one order of magnitude as compared to intact segments covered by endothelium. Six rabbits per group were examined. Even re-endothelialized segments showed a significantly higher uptake of the radiolabeled protein. Maximum arterial uptake varied between 12 (de- and re-endothelialized segments) and 24h (intact areas) after injection of (125)I-fibrinogen. In conclusion, these experiments for the first time suggest the increased uptake of radiolabeled fibrinogen in the aortic de-endothelized wall in rabbits.
authors: Department of Surgical, Radiological and Odontostomatological Sciences, University of Perugia, Perugia, Italy.
authors: Barbara
authors: B
authors: Palumbo
authors: Renato
authors: R
authors: Palumbo
authors: Anthony
authors: A
authors: Oguogho
authors: Graziana
authors: G
authors: Lupattelli
authors: Helmut
authors: H
authors: Sinzinger
mesh_terms: D000818:Animals; D001158:Arteries / Q000000981:diagnostic imaging / Q000378:metabolism*; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000378:metabolism*; D004195:Disease Models, Animal; D005340:Fibrinogen / Q000493:pharmacokinetics*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D009928:Organ Specificity; D011817:Rabbits; D011877:Radionuclide Imaging; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D005340:Fibrinogen