Chitosan-coated poly(vinyl alcohol) nanofibers for wound dressings.
A PVA nanofibrous matrix was prepared by electrospinning an aqueous 10 wt % PVA solution. The mean diameter of the PVA nanofibers electrospun from the PVA aqueous solution was 240 nm. The water resistance of the as-spun PVA nanofibrous matrix was improved by physically crosslinking the PVA nanofibers by heat treatment at 150 degrees C for 10 min, which were found to be the optimal heat treatment conditions determined from chemical and morphological considerations. In addition, the heat-treated PVA (H-PVA) nanofibrous matrix was coated with a chitosan solution to construct biomimetic nanofibrous wound dressings. The chitosan-coated PVA (C-PVA) nanofibrous matrix showed less hydrophilic and better tensile properties than the H-PVA nanofibrous matrix. The effect of the chitosan coating on open wound healing in a mouse was examined. The C-PVA and H-PVA nanofibrous matrices showed faster wound healing than the control. The histological examination and mechanical stability revealed the C-PVA nanofibrous matrix to be more effective as a wound-healing accelerator in the early stages of wound healing than the H-PVA nanofibrous matrix.
Kang
Yun Ok
YO
Department of Nanotechnology, Chungnam National University, Daejon 305-764, South Korea.
Yoon
In-Soo
IS
Lee
So Young
SY
Kim
Dae-Duk
DD
Lee
Seung Jin
SJ
Park
Won Ho
WH
Hudson
Samuel M
SM
D000818:Animals; D001458:Bandages; D001672:Biocompatible Materials; D032701:Biomimetics; D048271:Chitosan / Q000737:chemistry*; D004566:Electrodes; D006358:Hot Temperature; D051379:Mice; D008812:Mice, Hairless; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D013696:Temperature; D013718:Tensile Strength; D014867:Water / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects
D001672:Biocompatible Materials; D014867:Water; D011142:Polyvinyl Alcohol; D048271:Chitosan