Aging-related nicotinamide adenine dinucleotide oxidase response to dietary supplementation: the French paradox revisited.
Aging-related cell-surface NADH oxidase (arNOX)-specific activities increase with age between age 30 and ages 50-65. The protein is shed and circulates. Activity correlates with a number of aging-related disorders including low-density lipoprotein (LDL) oxidation as a precondition to atherosclerosis as well as oxidation of collagen and elastin as a major contributor to skin aging. arNOX inhibitors formulated for sustained release are capable of maintaining circulating arNOX at low levels with regular use as food supplements formulated with natural compounds. Among the best sources are certain culinary seasonings, all of which are ingredients used extensively in the French kitchen. Their regular use may contribute to an understanding of the nutritional basis for the French Paradox.
Morré
D James
DJ
NOX Technologies, Inc, West Lafayette, Indiana, USA. DJ_morre@yahoo.com
Morré
Dorothy M
DM
Shelton
Thomas B
TB
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood / Q000378:metabolism*; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology / Q000378:metabolism; D001688:Biological Products / Q000008:administration & dosage / Q000494:pharmacology; D019587:Dietary Supplements; D005260:Female; D005602:France; D006801:Humans; D008019:Life Style; D008077:Lipoproteins, LDL / Q000032:analysis / Q000097:blood; D008297:Male; D008875:Middle Aged; D009243:NAD / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D009747:Nutritional Physiological Phenomena / Q000187:drug effects; D010084:Oxidation-Reduction / Q000187:drug effects; D013481:Superoxides / Q000378:metabolism
D001688:Biological Products; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D009243:NAD; D013481:Superoxides; D009247:NADH, NADPH Oxidoreductases; C431909:tumor-associated NADH oxidase