Thermoresponsive hydrogel with embedded magnetic nanoparticles for the implementation of shrinkable medical microrobots and for targeting and drug delivery applications.
The paper describes the choice of a thermoresponsive material for the implementation of untethered medical microrobots and other microdevices. These entities can be propelled at a specific location in the body using a Magnetic Resonance Imaging (MRI) system while being actuated for various functions such as the release of drugs by a volume change induced by hyperthermia of nanoparticles embedded in the hydrogel. This paper presents some preliminary results showing that poly(N-isopropylacrylamide) (PNIPA) might be an interesting choice, because of the important volume decrease when temperature is increased of some degrees. Using PNIPA based microparticles could be an interesting choice because, according to our results, volume changes are more important when the volume is smaller, and shrinking rate is higher when there are nanoparticles embedded in the hydrogel.
Lapointe
Jacinthe
J
NanoRobotics Laboratory, Ecole Polytechnique de Montreal, QC, H3T 1J4 Canada. jacinthe.laponite@hotmail.com
Martel
Sylvain
S
D000178:Acrylamides / Q000737:chemistry; D000180:Acrylic Resins; D016503:Drug Delivery Systems; D004867:Equipment Design; D006358:Hot Temperature; D020100:Hydrogels / Q000737:chemistry*; D006979:Hyperthermia, Induced; D008279:Magnetic Resonance Imaging / Q000379:methods; D008280:Magnetics; D008904:Miniaturization; D008956:Models, Chemical; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012371:Robotics; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature
D000178:Acrylamides; D000180:Acrylic Resins; D020100:Hydrogels; D011108:Polymers; C052970:poly-N-isopropylacrylamide