Unanticipated toxicities from anticancer therapies: survivors' perspectives.
BACKGROUND
Improved therapies in oncology have resulted in increased survival across numerous malignancies, shifting attention to other aspects of the cancer experience. In particular, the impact of treatment-related toxicities has gained considerable attention, due to their physical and psychosocial effects, and possible impact on clinical outcome. These untoward events have not been examined from the survivors' perspective.


OBJECTIVE
To identify and describe treatment-related toxicities having a negative effect on quality of life from the perspective of cancer survivors.


METHODS
Quantitative study using written questionnaires and content analysis.


METHODS
Cancer survivors' workshop across the United States.


METHODS
A total of 379 participants from six survivor groups: breast (n = 250), ovarian (n =27), lung (n = 23), colorectal (n = 15), genitourinary (n = 23), and other cancers (n = 45).


METHODS
Survivors' perceptions on treatment-related dermatologic, gastrointestinal, and constitutional toxicities.


RESULTS
Survivors reported an increased concern regarding dermatologic toxicities, including irritated and dry skin, after receiving their cancer treatment. These events had a negative effect on their lives. Although gastrointestinal and constitutional toxicities also had a negative effect, the concern over their development was unchanged prior to and after treatments.


CONCLUSIONS
The impact of dermatologic toxicities is unanticipated prior to cancer treatments. Since these events have a negative effect on survivors' lives, pretreatment counseling and effective interventions are vital in order to maximize quality of life and minimize unnecessary treatment interruptions or discontinuations.
Gandhi
Mona
M
Department of Dermatology, Northwestern University's Feinberg School of Medicine, 676 N St Clair St, Suite 1600, Chicago, IL 60611, USA.
Oishi
Karen
K
Zubal
Beth
B
Lacouture
Mario E
ME
D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D011788:Quality of Life; D012189:Retrospective Studies; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology / Q000523:psychology*; D011795:Surveys and Questionnaires; D017741:Survivors