title: Hollow polymer microneedle array fabricated by photolithography process combined with micromolding technique.
abstract: Transdermal drug delivery through microneedles is a minimally invasive procedure causing little or no pain, and is a potentially attractive alternative to intramuscular and subdermal drug delivery methods. This paper demonstrates the fabrication of a hollow microneedle array using a polymer-based process combining UV photolithography and replica molding techniques. The key characteristic of the proposed fabrication process is to define a hollow lumen for microfluidic access via photopatterning, allowing a batch process as well as high throughput. A hollow SU-8 microneedle array, consisting of 825mum tall and 400 mum wide microneedles with 15-25 mum tip diameters and 120 mum diameter hollow lumens was designed, fabricated and characterized.
authors: School of Electrical and Computer Engineering of Georgia Institute of Technology, Atlanta, GA 30332, USA. pwang36@gatech.edu
authors: Po-Chun
authors: PC
authors: Wang
authors: Brock A
authors: BA
authors: Wester
authors: Swaminathan
authors: S
authors: Rajaraman
authors: Seung-Joon
authors: SJ
authors: Paik
authors: Seong-Hyok
authors: SH
authors: Kim
authors: Mark G
authors: MG
authors: Allen
mesh_terms: D000279:Administration, Cutaneous; D001698:Biomedical Engineering; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004867:Equipment Design; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation; D009339:Needles; D010781:Photography; D011108:Polymers
chemical_list: D011108:Polymers