title: A multimodal sensing device for fluorescence imaging and electrical potential measurement of neural activities in a mouse deep brain.
abstract: We have developed a multimodal CMOS sensing device to detect fluorescence image and electrical potential for neural activities in a mouse deep brain. The device consists of CMOS image sensor with on-chip electrodes and excitation light sources, all of which are integrated on a polyimide substrate. The novel feature of this device is its embedded on-chip electrodes which are partially transmit incident light so that the whole image can be acquired by the sensor. We have demonstrated the CMOS sensor device successfully operates in hippocampus area of an anesthetized mouse.
authors: Graduate School of Materials Science, Nara Institute of Science and Technology, and JST, CREST, Ikoma, Nara 630-0101, Japan. ohta@ms.naist.jp
authors: Jun
authors: J
authors: Ohta
authors: Ayato
authors: A
authors: Tagawa
authors: Hiroki
authors: H
authors: Minami
authors: Toshihiko
authors: T
authors: Noda
authors: Kiyotaka
authors: K
authors: Sasagawa
authors: Takashi
authors: T
authors: Tokuda
authors: Yumiko
authors: Y
authors: Hatanaka
authors: Yasuyuki
authors: Y
authors: Ishikawa
authors: Hideki
authors: H
authors: Tamura
authors: Sadao
authors: S
authors: Shiosaka
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001921:Brain / Q000502:physiology*; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008029:Lighting / Q000295:instrumentation*; D051379:Mice; D008856:Microscopy, Fluorescence / Q000295:instrumentation*; D008904:Miniaturization; D009474:Neurons / Q000502:physiology*; D015203:Reproducibility of Results; D012666:Semiconductors; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D018511:Systems Integration