Juzentaihoto (TJ-48), a traditional Japanese herbal medicine, influences hemoglobin recovery during preoperative autologous blood donation and after hip surgery.
OBJECTIVE
Preoperative autologous blood donation is a widely used alternative to allogenic transfusion in hip surgery. However, it has been reported that autologous blood donation may induce preoperative anemia. Juzentaihoto (TJ-48) (Tsumura Co., Tokyo, Japan) is a Japanese herbal medicine that has been used to alleviate anemia. We investigated the effect of TJ-48 on anemia in the perioperative period.


METHODS
18 hips of 18 female patients who underwent total hip arthroplasty or rotational acetabular osteotomy (RAO) were divided into two groups. Group A consisted of 9 hips of 9 patients who were treated with TJ-48 at a dose of 7.5 g per day from 21 days before surgery to the day before surgery. Group B consisted of 9 hips of 9 patients who did not take TJ-48. Preoperative autologous blood donation was performed 21, 14 and 7 days before surgery. All patients deposited 400 ml each time for a total of 1,200 ml. Hemoglobin level was recorded on preoperative Days 21, 14 and 7 and postoperative Days 1, 4, 7 and 14.


RESULTS
During the preoperative period, repeated measures ANOVA showed a significant difference between the two groups in hemoglobin level (p = 0.04). Despite the lack of TJ-48 after surgery, the rate of hemoglobin decline in Group A was less than in Group B at all examination times. No patients with TJ-48 experienced side effects, including gastrointestinal symptoms and unusual laboratory data.


CONCLUSIONS
TJ-48 is useful for treating anemia during preoperative autologous donation.
Kishida
Y
Y
Department of Kampo Medicine, Osaka University Graduate School of Medicine, Osaka, Japan. yu-kishida@umin.ac.jp
Nishii
T
T
Inoue
T
T
Nishida
S
S
Arimitsu
J
J
Yoshikawa
H
H
Sugano
N
N
D000077:Acetabulum / Q000601:surgery; D000740:Anemia / Q000139:chemically induced / Q000517:prevention & control*; D019644:Arthroplasty, Replacement, Hip; D044466:Asian People; D001804:Blood Transfusion, Autologous / Q000009:adverse effects; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D010027:Osteotomy; D011183:Postoperative Complications / Q000517:prevention & control*; D011300:Preoperative Care / Q000379:methods*; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; D006454:Hemoglobins; C063587:juzentaihoto