title: Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.
abstract: Proper thymocyte development is required to establish T-cell central tolerance and to generate naive T cells, both of which are essential for T-cell homeostasis and a functional immune system. Here we demonstrate that the loss of transcription factor Foxp1 results in the abnormal development of T cells. Instead of generating naive T cells, Foxp1-deficient single-positive thymocytes acquire an activated phenotype prematurely in the thymus and lead to the generation of peripheral CD4(+) T and CD8(+) T cells that exhibit an activated phenotype and increased apoptosis and readily produce cytokines upon T-cell receptor engagement. These results identify Foxp1 as an essential transcriptional regulator for thymocyte development and the generation of quiescent naive T cells.
authors: Immunology Program and Wistar Vaccine Center, The Wistar Institute, Philadelphia, PA, USA.
authors: Xiaoming
authors: X
authors: Feng
authors: Gregory C
authors: GC
authors: Ippolito
authors: Lifeng
authors: L
authors: Tian
authors: Karla
authors: K
authors: Wiehagen
authors: Soyoung
authors: S
authors: Oh
authors: Arivazhagan
authors: A
authors: Sambandam
authors: Jessica
authors: J
authors: Willen
authors: Ralph M
authors: RM
authors: Bunte
authors: Shanna D
authors: SD
authors: Maika
authors: June V
authors: JV
authors: Harriss
authors: Andrew J
authors: AJ
authors: Caton
authors: Avinash
authors: A
authors: Bhandoola
authors: Philip W
authors: PW
authors: Tucker
authors: Hui
authors: H
authors: Hu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000276:immunology; D002454:Cell Differentiation / Q000235:genetics* / Q000276:immunology; D049109:Cell Proliferation; D002478:Cells, Cultured; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000502:physiology*; D051379:Mice; D020297:Mice, Congenic; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010641:Phenotype; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology*; D013601:T-Lymphocytes / Q000378:metabolism / Q000502:physiology*; D013950:Thymus Gland / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
chemical_list: D051858:Forkhead Transcription Factors; C432917:Foxp1 protein, mouse; D012097:Repressor Proteins; D014157:Transcription Factors