Nafamostat mesilate is not appropriate as an anticoagulant during continuous renal replacement therapy in dogs.
We performed continuous renal replacement therapy (CRRT) in clinically healthy dogs (n=7) to evaluate the utility of nafamostat mesilate (NM) as an anticoagulant. In 3 of the 7 dogs, CRRT had to be discontinued before the target duration due to coagulation in the extracorporeal circuit, into which NM was administered constantly at the rate of 2.0-6.0 mg/kg per hour. The rate of administration of NM was greater than the recommended dose of NM in humans. Further, all the dogs suffered vomiting during CRRT with NM infusion. We therefore recommend that NM is not used as an anticoagulant during CRRT in dogs.
Shimokawa Miyama
Takako
T
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.
Yoshioka
Chihiro
C
Minami
Koji
K
Okawa
Takumi
T
Hiraoka
Hiroko
H
Itamoto
Kazuhito
K
Mizuno
Takuya
T
Okuda
Masaru
M
D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D001550:Benzamidines; D001806:Blood Urea Nitrogen; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood; D004285:Dogs; D006146:Guanidines / Q000009:adverse effects*; D006440:Hemofiltration / Q000379:methods / Q000662:veterinary; D011188:Potassium / Q000097:blood; D006435:Renal Dialysis / Q000662:veterinary; D017582:Renal Replacement Therapy / Q000379:methods*; D012709:Serum Albumin / Q000187:drug effects / Q000378:metabolism; D012964:Sodium / Q000097:blood
D000925:Anticoagulants; D001550:Benzamidines; D006146:Guanidines; D012709:Serum Albumin; D012964:Sodium; D003404:Creatinine; D011188:Potassium; D002118:Calcium; C032855:nafamostat