Biological microdevice with fluidic acoustic streaming for measuring uric acid in human saliva.
The healthcare system requires new devices for a rapid monitoring of a patient in order to improve the diagnosis and treatment of various diseases. Accordingly, new biomedical devices are being developed. In this paper, a fully-integrated biological microdevice for uric acid analysis in human saliva is presented. It is based on optical spectrophotometric measurements and incorporates a mixture system based on acoustic streaming, that enhances the fluids reaction due to both heating and agitation generated by this effect. Acoustic streaming is provided by a piezoelectric beta-PVDF film deposited underneath the microfluidic die of the device. Further, it incorporates the electronics for the detection, readout, data processing and signal actuation. Experimental results proved that acoustic streaming based on this piezoelectric polymer is advantageous and reduces in 55% the time required to obtain the analysis results.
Cardoso
V F
VF
University of Minho, Department of Industrial Electronics, Campus de Azurém, 4800-058 Guimarães, Portugal. vanessa@dei.uminho.pt
Catarino
S O
SO
Martins
P
P
Rebouta
L
L
Lanceros-Mendéz
S
S
Minas
G
G
D000162:Acoustics / Q000295:instrumentation*; D015374:Biosensing Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D017022:Flow Injection Analysis / Q000295:instrumentation*; D006801:Humans; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D044085:Microfluidics / Q000295:instrumentation*; D008904:Miniaturization; D015203:Reproducibility of Results; D012463:Saliva / Q000378:metabolism*; D012680:Sensitivity and Specificity; D014527:Uric Acid / Q000032:analysis*
D014527:Uric Acid