Sensitivity of hemoglobin concentration on optical probe positioning in image-guided near infrared spectroscopy.
Multi-modality image-guided near infrared spectroscopy provides volume-based quantification of total hemoglobin, oxygen saturation, water and scatter in various tissue types in-vivo. The accuracy of these parameters depends on the location of the imaging probe and its distance from the tumor. In a numerical study, we have performed simulation to analyze this effect in a breast-specific imaging domain. Results show that the accuracy of total hemoglobin decreases by 25% for every centimeter away from the tumor center, for a typical size of 35mm cancer in the breast. Image guidance is necessary for accurate positioning, and multi-plane acquisition can improve this accuracy.
Srinivasan
Subhadra
S
Dartmouth College, Hanover, NH 03755 USA. subhadra.srinivasan@dartmouth.edu
Carpenter
Colin
C
Pogue
Brian W
BW
D001940:Breast / Q000033:anatomy & histology / Q000098:blood supply*; D001943:Breast Neoplasms / Q000473:pathology; D044584:Carcinoma, Ductal / Q000473:pathology*; D003198:Computer Simulation; D005260:Female; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D019047:Phantoms, Imaging; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation / Q000379:methods*
D006454:Hemoglobins