title: Impact of ethanol on the developing GABAergic system.
abstract: Alcohol intake during pregnancy has a tremendous impact on the developing brain. Embryonic and early postnatal alcohol exposures have been investigated experimentally to elucidate the fetal alcohol spectrum disorders' (FASD) milieu, and new data have emerged to support a devastating effect on the GABAergic system in the adult and developing nervous system. GABA is a predominantly inhibitory neurotransmitter that during development excites neurons and orchestrates several developmental processes such as proliferation, migration, differentiation, and synaptogenesis. This review summarizes and brings new data on neurodevelopmental aspects of the GABAergic system with FASD in experimental telencephalic models.
authors: Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors: Ricardo Noboro
authors: RN
authors: Isayama
authors: Paulo Emilio Correa
authors: PE
authors: Leite
authors: Jean Pierre Mendes
authors: JP
authors: Lima
authors: Daniela
authors: D
authors: Uziel
authors: Edna Nanami
authors: EN
authors: Yamasaki
mesh_terms: D020268:Alcohol-Induced Disorders, Nervous System / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000633:toxicity; D004195:Disease Models, Animal; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D051379:Mice; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009434:Neural Pathways / Q000187:drug effects / Q000196:embryology / Q000254:growth & development; D055495:Neurogenesis / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D013687:Telencephalon / Q000187:drug effects* / Q000196:embryology* / Q000254:growth & development; D005680:gamma-Aminobutyric Acid / Q000187:drug effects* / Q000378:metabolism
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol; D005680:gamma-Aminobutyric Acid