Clomiphene citrate plus tamoxifen versus laparoscopic ovarian drilling in women with clomiphene-resistant polycystic ovary syndrome.
OBJECTIVE
To compare the efficacy of clomiphene citrate (CC) plus tamoxifen with that of laparoscopic ovarian drilling in clomiphene-resistant women with polycystic ovary syndrome (PCOS).


METHODS
We randomly allocated 150 women with CC-resistant PCOS to a combined medication group (group 1) or a laparoscopic surgery group (group 2). The primary outcome was the live birth rate in each group; secondary outcomes were the rates of ovulation, clinical pregnancy and miscarriage.


RESULTS
There were no significant differences between the groups regarding rates of ovulation (81.3% vs 85.3%), pregnancy (53.3% vs 50.7%), or live births (49.3% vs 44.0%), but the mean endometrium thickness was significantly greater on the day of human chorionic gonadotropin administration in group 1 (P<0.001).


CONCLUSIONS
Clomiphene citrate plus tamoxifen was as effective as laparoscopic ovarian drilling in promoting ovulation and pregnancy.
Zakherah
Mahmoud S
MS
Women's Health Center, Department of Obstetrics and Gynecology, Assiut University, Assiut, Egypt.
Nasr
Ahmed
A
El Saman
Aly M
AM
Shaaban
Omar M
OM
Shahin
Ahmed Y
AY
D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010535:Laparoscopy; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000601:surgery; D011247:Pregnancy; D013629:Tamoxifen / Q000627:therapeutic use*; D055815:Young Adult
D004965:Estrogen Antagonists; D013629:Tamoxifen; D002996:Clomiphene