Ambient temperature nitrogen-directed difluoroalkynylborane Carboni-Lindsey cycloaddition reactions.
The in situ generation of alkynyldifluoroboranes in the presence of N-heterocycle substituted tetrazines provides a convenient and direct method for the synthesis of pyridazine difluoroboranes. The reactions proceed in 10 min under ambient conditions and provide the opportunity to assemble unsymmetrical products with complete regiocontrol.
Vivat
Jérôme F
JF
Department of Chemistry, University of Sheffield, Brook Hill, Sheffield S3 7HF, UK.
Adams
Harry
H
Harrity
Joseph P A
JP