title: Intraspecies transmission of L-type-like Bovine Spongiform Encephalopathy detected in Japan.
abstract: It has been assumed that the agent causing BSE in cattle is a uniform strain (classical BSE); however, different neuropathological and molecular phenotypes of BSE (atypical BSE) have been recently reported. We demonstrated the successful transmission of L-type-like atypical BSE detected in Japan (BSE/JP24 isolate) to cattle. Based on the incubation period, neuropathological hallmarks, and molecular properties of the abnormal host prion protein, the characteristics of BSE/JP24 prion were apparently distinguishable from the classical BSE prion and closely resemble those of bovine amyloidotic spongiform encephalopathy prion detected in Italy.
authors: Molecular Biotechnology Laboratory, Hokkaido Animal Research Center, Shintoku, Hokkaido, Japan.
authors: Shigeo
authors: S
authors: Fukuda
authors: Yoshifumi
authors: Y
authors: Iwamaru
authors: Morikazu
authors: M
authors: Imamura
authors: Kentarou
authors: K
authors: Masujin
authors: Yoshihisa
authors: Y
authors: Shimizu
authors: Yuichi
authors: Y
authors: Matsuura
authors: Yujing
authors: Y
authors: Shu
authors: Megumi
authors: M
authors: Kurachi
authors: Kazuo
authors: K
authors: Kasai
authors: Yuichi
authors: Y
authors: Murayama
authors: Sadao
authors: S
authors: Onoe
authors: Ken'ichi
authors: K
authors: Hagiwara
authors: Tetsutaro
authors: T
authors: Sata
authors: Shirou
authors: S
authors: Mohri
authors: Takashi
authors: T
authors: Yokoyama
authors: Hiroyuki
authors: H
authors: Okada
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics / Q000473:pathology / Q000635:transmission*; D016643:Encephalopathy, Bovine Spongiform / Q000235:genetics / Q000473:pathology / Q000635:transmission*; D055256:Infectious Disease Incubation Period; D007564:Japan; D008526:Medulla Oblongata / Q000473:pathology; D051379:Mice; D018621:PrPC Proteins / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D017096:Prion Diseases / Q000235:genetics / Q000635:transmission; D011328:Prions / Q000145:classification / Q000472:pathogenicity; D013045:Species Specificity
chemical_list: D018621:PrPC Proteins; D011328:Prions