[The response of human cancer stem cells on low-dose X-ray exposure].
Recently we found that transposition of homologous chromosomes 1q12 loci towards the nuclear centre and activation of the chromosomal nucleolus-forming regions (NFR) are observed in human lymphocytes after exposure to low doses of X-radiation (10 cGy). These cell reactions were studied for human breast cancer stem cell cultures. There are two cell types in cell culture from single donor: with two (type 1) and three (type 2) loci of 1q12. It was shown that an adaptive response induced by X-ray irradiation is developed only in cells of the type 1 but not in type 2 ones after 3 and 10 cGy doses. We observed a considerable death of cell type 2 after low-dose exposure. Activation of the NFR in breast cancer stem cells after irradiation was not found. In this paper we discuss features of studied cancer stem cells lines and their responses to low doses of ionizing radiation.
Ermakov
A V
AV
Kon'kova
M S
MS
Kostiuk
S V
SV
Ershova
E S
ES
Smirnova
T D
TD
Kameneva
L V
LV
Efremova
L V
LV
Liubchenko
L N
LN
Veĭko
N N
NN
D000230:Adenocarcinoma / Q000648:ultrastructure*; D001943:Breast Neoplasms / Q000648:ultrastructure*; D002466:Cell Nucleolus / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D014411:Neoplastic Stem Cells / Q000528:radiation effects* / Q000648:ultrastructure; D009697:Nucleolus Organizer Region / Q000528:radiation effects*; D011836:Radiation Tolerance; D014407:Tumor Cells, Cultured; D014965:X-Rays