title: Tula hantavirus NSs protein accumulates in the perinuclear area in infected and transfected cells.
abstract: The small RNA segment of some hantaviruses (family Bunyaviridae) encodes two proteins: the nucleocapsid protein and, in an overlapping reading frame, a non-structural (NSs) protein. The hantavirus NSs protein, like those of orthobunya- and phleboviruses, counteracts host innate immunity. Here, for the first time, the NSs protein of a hantavirus (Tula virus) has been observed in infected cells and shown to localize in the perinuclear area. Transiently expressed NSs protein showed similar localization, although the kinetics was slightly different, suggesting that to reach its proper location in the infected cell, the NSs protein does not have to cooperate with other viral proteins.
authors: Infection Biology Research Program, Department of Virology, Haartman Institute, University of Helsinki, PO Box 21, Haartmaninkatu 3, 00014 Helsinki, Finland. oskari.virtanen@helsinki.fi
authors: Jussi Oskari
authors: JO
authors: Virtanen
authors: Kirsi Maria
authors: KM
authors: Jääskeläinen
authors: Janica
authors: J
authors: Djupsjöbacka
authors: Antti
authors: A
authors: Vaheri
authors: Alexander
authors: A
authors: Plyusnin
mesh_terms: D000818:Animals; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism*; D002522:Chlorocebus aethiops; D006476:Orthohantavirus / Q000235:genetics / Q000378:metabolism*; D018778:Hantavirus Infections / Q000378:metabolism* / Q000821:virology; D006801:Humans; D008969:Molecular Sequence Data; D021381:Protein Transport; D014162:Transfection; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D017361:Viral Nonstructural Proteins