title: Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW).
abstract: The 3.1-Mb genome of an outbreak methicillin-resistant Staphylococcus aureus (MRSA) strain (TW20) contains evidence of recently acquired DNA, including two large regions (635 kb and 127 kb). The strain is resistant to a wide range of antibiotics, antiseptics, and heavy metals due to resistance genes encoded on mobile genetic elements and also mutations in housekeeping genes.
authors: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom. mh3@sanger.ac.uk
authors: Matthew T G
authors: MT
authors: Holden
authors: Jodi A
authors: JA
authors: Lindsay
authors: Craig
authors: C
authors: Corton
authors: Michael A
authors: MA
authors: Quail
authors: Joshua D
authors: JD
authors: Cockfield
authors: Smriti
authors: S
authors: Pathak
authors: Rahul
authors: R
authors: Batra
authors: Julian
authors: J
authors: Parkhill
authors: Stephen D
authors: SD
authors: Bentley
authors: Jonathan D
authors: JD
authors: Edgeworth
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D016680:Genome, Bacterial / Q000235:genetics*; D019216:Metals, Heavy / Q000633:toxicity; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000235:genetics*; D008957:Models, Genetic; D008969:Molecular Sequence Data
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D019216:Metals, Heavy