Adenosine induces G2/M cell-cycle arrest by inhibiting cell mitosis progression.
Cellular adenosine accumulates under stress conditions. Few papers on adenosine are concerned with its function in the cell cycle. The cell cycle is the essential mechanism by which all living things reproduce and the target machinery when cells encounter stresses, so it is necessary to examine the relationship between adenosine and the cell cycle. In the present study, adenosine was found to induce G-2/M cell-cycle arrest. Furthermore, adenosine was found to modulate the expression of some important proteins in the cell cycle, such as cyclin B and p21, and to inhibit the transition of metaphase to anaphase in mitosis.
Jia
Kun-Zhi
KZ
Jiangsu Center of Hepatobiliary Diseases, State Key Laboratory of Pharmaceutical Biotechnology, Affiliated Gulou Hospital, Nanjing University, Nanjing 210093, People's Republic of China.
Tang
Bo
B
Yu
Lu
L
Cheng
Wei
W
Zhang
Rong
R
Zhang
Jian-Fa
JF
Hua
Zi-Chun
ZC
D000241:Adenosine / Q000494:pharmacology*; D000705:Anaphase; D002455:Cell Division; D002460:Cell Line; D019926:Cyclin B / Q000378:metabolism; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism; D005434:Flow Cytometry; D016195:G2 Phase; D006801:Humans; D008677:Metaphase; D008856:Microscopy, Fluorescence; D008938:Mitosis
D019926:Cyclin B; D050759:Cyclin-Dependent Kinase Inhibitor p21; D000241:Adenosine