title: Pyridyl-substituted corrole isomers: synthesis and their regulation to G-quadruplex structures.
abstract: G-quadruplex DNA plays an important role in the potential therapeutic target for the design and development of anticancer drugs. As various G-quadruplex sequences in the promoter regions or telomeres can form different secondary structural modes and display a diversity of biology functions, variant G-quadruplex interactive agents may be necessary to cure different disease by differentiating variant types of G-quadruplexes. We synthesize five cationic methylpyridylium corroles and compare the interactions of corroles with different types of G-quadruplexes such as cmyc, htelo, and bcl2 by using surface plasmon resonance. Because of the importance of human telomere G-quadruplex DNA, we focus on the biological properties of the interactions between human telomere G-quadruplex DNA and corrole isomers using CD, T(m), PCR-stop (PCR= polymerase chain reaction), and polymerase-stop assay, which demonstrate the excellent ability of the corrole to induce and stabilize the G-quadruplex. This study provides the first experimental insight into how selectivity might be achieved for different G-quadruplexes by a single group of methylpyridylium corrole isomers that may be optimized for potential selective cancer therapy.
authors: College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P.R. China.
authors: Heng
authors: H
authors: Ma
authors: Ming
authors: M
authors: Zhang
authors: Dan
authors: D
authors: Zhang
authors: Rong
authors: R
authors: Huang
authors: Yang
authors: Y
authors: Zhao
authors: Hao
authors: H
authors: Yang
authors: Yijing
authors: Y
authors: Liu
authors: Xiaocheng
authors: X
authors: Weng
authors: Yangyang
authors: Y
authors: Zhou
authors: Minggang
authors: M
authors: Deng
authors: Liang
authors: L
authors: Xu
authors: Xiang
authors: X
authors: Zhou
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002942:Circular Dichroism; D054856:G-Quadruplexes; D007536:Isomerism; D007700:Kinetics; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*; D020349:Surface Plasmon Resonance; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000378:metabolism; D044366:Transition Temperature
chemical_list: D000970:Antineoplastic Agents; D011166:Porphyrins; D011725:Pyridines; C431863:corrole; D019098:Telomerase; C023666:pyridine