Activation of γδ T cells by bisphosphonates.
After decades of successful clinical use, the exact molecular mechanisms by which the anti-resorptive bisphosphonate drugs (BPs) exert their effects are now being revealed. In addition to their anti-resorptive effects, it is now apparent that nitrogen-containing BPs (N-BPs) have immunomodulatory properties. Specifically, these drugs activate immune cells called gamma, delta T lymphocytes. In this chapter we discuss the mechanism of gamma, delta T cell activation by N-BPs and propose that N-BPs may provide a safe and effective means for manipulating gamma,delta T cell activity in future immunotherapeutic approaches.
Thompson
Keith
K
Bone and Musculoskeletal Research Programme, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Aberdeen, UK. k.thompson@abdn.ac.uk
Roelofs
Anke J
AJ
Jauhiainen
Marjo
M
Mönkkönen
Hannu
H
Mönkkönen
Jukka
J
Rogers
Michael J
MJ
D000210:Acute-Phase Reaction / Q000276:immunology; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004164:Diphosphonates / Q000737:chemistry / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology*
D004164:Diphosphonates; D016692:Receptors, Antigen, T-Cell, gamma-delta