title: Factors for determining survival in acute organophosphate poisoning.
abstract: OBJECTIVE
  Organophosphate poisoning has a high mortality rate. Recently, differences among organophosphorus insecticides in human self-poisoning were reported. This study investigated the prognostic risk factors and the mortality of different organophosphates following acute organophosphate poisoning.
  
  
  METHODS
  This retrospective study included 68 patients with acute organophosphate poisoning. We investigated patient survival according to initial parameters, including the initial Acute Physiology and Chronic Health Evaluation (APACHE) II score, serum cholinesterase level, and hemoperfusion and evaluated the mortality according to organophosphate types.
  
  
  RESULTS
  Thirteen of the 68 patients died. The agents responsible for mortality were different. The APACHE II score was a significant predictor of mortality (odds ratio [OR], 1.194; p<0.01; 95% confidence interval [CI], 1.089 to 1.309) and respiratory failure (OR, 1.273; p<0.01; 95% CI, 1.122 to 1.444). The mortality was 0% for dichlorvos, malathion, chlorpyrifos and profenofos. However, other organophosphates showed different mortality (16.7% for O-ethyl-O-4-nitrophenyl phenylphosphonothioate, 25% for phenthoate, 37.5% for phosphamidon, 50% for methidathion). The usefulness of hemoperfusion appears to be limited.
  
  
  CONCLUSIONS
  The initial APACHE II score is a useful prognostic indicator, and different organophosphates have different mortality.
authors: Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
authors: Eun-Jung
authors: EJ
authors: Kang
authors: Su-Jin
authors: SJ
authors: Seok
authors: Kwon-Hyun
authors: KH
authors: Lee
authors: Hyo-Wook
authors: HW
authors: Gil
authors: Jong-Oh
authors: JO
authors: Yang
authors: Eun-Young
authors: EY
authors: Lee
authors: Sae-Yong
authors: SY
authors: Hong
mesh_terms: D018806:APACHE; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002802:Cholinesterases / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062025:Organophosphate Poisoning; D011041:Poisoning / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D002802:Cholinesterases