How mitochondria record the effects of UV exposure and oxidative stress using human skin as a model tissue.
The accumulation of mitochondrial DNA (mtDNA) mutations has been proposed as an underlying cause of the ageing process and mutations have been associated with cancer in many tissues, including human skin. This involvement is linked to the key roles of mitochondrial function and mtDNA in oxidative stress production and as a mediator of apoptosis. We and others have pioneered the use of mtDNA damage as a highly sensitive biomarker of ultraviolet exposure in human skin and have also shown that the accumulation of an ageing-dependent mtDNA mutation is accelerated by exposure to sunlight, which is known to induce oxidative stress in skin. This is important as ultraviolet radiation (UVR)-induced gene mutations play a key role in the development of skin cancer and ageing in human skin. Novel applications of mtDNA as a biomarker of UVR-induced oxidative stress will also be highlighted in this review.
Birch-Machin
Mark A
MA
Department of Dermatological Sciences, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. m.a.birch-machin@ncl.ac.uk
Swalwell
Helen
H
D004272:DNA, Mitochondrial / Q000235:genetics* / Q000528:radiation effects*; D006801:Humans; D008928:Mitochondria / Q000528:radiation effects*; D008954:Models, Biological; D018384:Oxidative Stress; D012867:Skin / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*
D004272:DNA, Mitochondrial