Treatment of relapsing Mycobacterium avium infection with interferon-gamma and interleukin-2 in an HIV-negative patient with low CD4 syndrome.
A patient with idiopathic CD4 T-lymphopenia was diagnosed with a recurrent disseminated Mycobacterium avium infection. Because of progressive disease, treatment with interferon-gamma (IFN-γ) and interleukin-2 (IL-2) was started. The patient was successfully treated with IFN-γ-1b and IL-2 in addition to anti-mycobacterial combination therapy. To our knowledge, this is the first report of successful combination therapy with IFN-γ-1b and IL-2 in a patient with idiopathic CD4 T-lymphopenia. Short-term IFN-γ-1b and IL-2 might be considered as therapeutic options in refractory mycobacterial infections in patients with idiopathic CD4 lymphopenia.
Sternfeld
T
T
II. Medizinische Klinik und Poliklinik, Infektionsambulanz, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse 22, Munich, Germany. thomas.sternfeld@web.de
Nigg
A
A
Belohradsky
B H
BH
Bogner
J R
JR
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D018023:HIV Seronegativity; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use*; D007376:Interleukin-2 / Q000627:therapeutic use*; D008231:Lymphopenia / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy* / Q000209:etiology; D011994:Recombinant Proteins; D012008:Recurrence; D013577:Syndrome
D000276:Adjuvants, Immunologic; D007376:Interleukin-2; D011994:Recombinant Proteins; D007371:Interferon-gamma