[Diagnosis and treatment of iron deficiency without anaemia].
Iron deficiency (ID) without anaemia frequently remains undiagnosed when symptoms are attributed to ID with anaemia. Serum ferritin is the primary diagnostic parameter, whereas <10 microg/l represent depleted iron stores, 10-30 microg/l can confirm ID without anaemia and 30-50 microg/l might indicate functional ID. In case of increased CRP or ALT, normal/elevated ferritin should be interpreted with caution. Intravenous iron is indicated if oral iron is not effective or tolerated. At ferritin <10 microg/l, a cumulative dose of 1000 mg iron and at ferritin 10-30 microg/l, a cumulative dose of 500 mg is advised. At ferritin 30-50 microg/l a first dose of 200 mg might be considered. Ferritin shall be reassessed not sooner than 2 weeks after the last oral or 8-12 weeks after the last iv iron administration.
Fehr
J
J
Vormals Klinik für Hämatologie. haemfej@gmail.com
Favrat
B
B
Schleiffenbaum
B
B
Krayenbühl
P A
PA
Kapanci
C
C
von Orelli
F
F
D000505:Alopecia / Q000097:blood / Q000209:etiology; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000175:diagnosis*; D003072:Cognition Disorders / Q000097:blood / Q000209:etiology; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D004304:Dosage Forms; D005221:Fatigue / Q000097:blood / Q000209:etiology; D005293:Ferritins / Q000097:blood; D006801:Humans; D007501:Iron / Q000008:administration & dosage / Q000097:blood; D058085:Iron Compounds / Q000008:administration & dosage / Q000009:adverse effects; D000090463:Iron Deficiencies; D012016:Reference Values; D012148:Restless Legs Syndrome / Q000097:blood / Q000209:etiology
D004304:Dosage Forms; D058085:Iron Compounds; D005293:Ferritins; D007501:Iron