A case report of an uncommon sex-cord stromal tumor consisted of luteal and sertoli cells in a spayed bitch.
We report a rare case of benign sex cord-stromal tumor consisted largely of luteoma with minor portion of Sertoli cell tumor located at the position of the left ovary excision in an 11-year-old ovariectomized bitch. Granulosa cell component was lacking, and both luteal and Sertoli cell portions were entirely positive for inhibin alpha and neuron-specific enolase, whereas luteoma portion alone was positive for Wilms' tumor-1 (WT1), immunohistochemically. The results suggest that this tumor is a possible complication of incomplete ovarian excision at the time of ovariectomy and consisted of uncommon hybrid of luteal and Sertoli cells to be diagnosed as an unclassified sex cord-stromal tumor if applied in human cases. WT1-expression pattern suggested the signature of the difference in the phenotype of these cell types.
Ichimura
Ryohei
R
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan.
Shibutani
Makoto
M
Mizukami
Sayaka
S
Suzuki
Terumasa
T
Shimada
Yuko
Y
Mitsumori
Kunitoshi
K
D000818:Animals; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008184:Luteal Cells / Q000473:pathology; D008297:Male; D010051:Ovarian Neoplasms / Q000473:pathology / Q000662:veterinary*; D012708:Sertoli Cells / Q000473:pathology; D018312:Sex Cord-Gonadal Stromal Tumors / Q000473:pathology / Q000662:veterinary*