title: [A case of rectal GIST treated with imatinib mesylate neoadjuvant therapy to preserve the anus].
abstract: A 64-year-old man was admitted to our hospital with anal pain on evacuation. MRI revealed a large rectal submucosal tumor, more than 6 cm in diameter. Fine needle histological diagnosis indicated GIST with moderate risk. The patient was treated with imatinib mesylate in order to preserve the anus. The anal pain and tumor size decreased. Trans-anal local excision was performed. This case suggests that imatinib mesylate can make it possible to treat large rectal GIST cases by preserving anus, if neoadjuvant chemotherapy can be effective.
authors: Department of Gastroenterology, Kyoto First Red Cross Hospital, Japan. satoru-sekoguchi@kyoto1-jrc.org
authors: Satoru
authors: S
authors: Sekoguchi
authors: Yusuke
authors: Y
authors: Okuyama
authors: Yasuyuki
authors: Y
authors: Enoki
authors: Takumi
authors: T
authors: Kawakami
authors: Akira
authors: A
authors: Tomie
authors: Nobuhisa
authors: N
authors: Yamada
authors: Hiroyuki
authors: H
authors: Yoriki
authors: Akifumi
authors: A
authors: Fukui
authors: Takeshi
authors: T
authors: Hattori
authors: Kazuhiro
authors: K
authors: Kamata
authors: Naoya
authors: N
authors: Tomatsuri
authors: Hideki
authors: H
authors: Nakamura
authors: Hideki
authors: H
authors: Sato
authors: Hiroyuki
authors: H
authors: Kimura
authors: Norimasa
authors: N
authors: Yoshida
authors: Yasuhiro
authors: Y
authors: Shioaki
authors: Sotaro
authors: S
authors: Fujimoto
mesh_terms: D001003:Anal Canal; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy*; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D012004:Rectal Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate