title: The correlation among QTc interval, hyperglycaemia and the impaired autonomic activity.
abstract: BACKGROUND
  The QT interval reflects the duration of the intracellular action potential. Little is known on the interval QT duration in non diabetic insulin-resistant subjects.
  
  
  OBJECTIVE
  The aims of the current study were to evaluate the QTc interval in three groups of non diabetic insulin-resistant subjects and the possible correlation between QTc and the autonomic nervous system's activity.
  
  
  METHODS
  90 subjects were divided in subjects with impaired fasting glycaemia (IFG) and, by the results of OGTT, according to the criteria of ADA, in subjects with normal glucose regulation (NGR) and impaired glucose tolerance (IGT). Insulin resistance was evaluated by the homeostasis model assessment-index (HOMA-I). Heart rate variability and Qtc were calculated.
  
  
  RESULTS
  QTc interval is correlated with SDNN, LF n.u. and LF/HF.
  
  
  CONCLUSIONS
  We have observed that the QTc interval is prolonged in insulin-resistant subjects with associated impaired glucose metabolism, while no difference was reported between insulin-resistant and non insulin-resistant subjects with normal glucose regulation. We hypothesize that hyperglycaemia could play a major role than hyperinsulinemia on the QTc prolongation.
authors: UO Geriatria, Hospital of Montefiascone POC, Viterbo, Italy. fiorentini-a@libero.it
authors: Alessandra
authors: A
authors: Fiorentini
authors: Antonio
authors: A
authors: Perciaccante
authors: Rosita
authors: R
authors: Valente
authors: Alberto
authors: A
authors: Paris
authors: Pietro
authors: P
authors: Serra
authors: Luigi
authors: L
authors: Tubani
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001342:Autonomic Nervous System Diseases / Q000150:complications*; D001786:Blood Glucose / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D004562:Electrocardiography; D005260:Female; D007839:Functional Laterality; D005951:Glucose Tolerance Test / Q000379:methods; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D007333:Insulin Resistance / Q000502:physiology; D008133:Long QT Syndrome / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D001786:Blood Glucose