title: Selective micro preconcentration of propofol for anesthetic depth monitoring by using seedless electroplated gold as adsorbent.
abstract: This communication presents selective preconcentration of the anesthetic agent (Propofol) and the elimination of unwanted species from a representative sample of human breath. In this approach, a micro preconcentrator (microPC) consisting of embedded high-aspect-ratio pillars (30 microm x 120 microm chi 240 microm), an outer dimensions of 7 mm x 7 mm (encompass more than 3500 micro pillars), total inner surface area of approximately 10 m(2), and a total inner volume of approximately 6.5 microL was used to selectively preconcentrate Propofol. The microPC has on-chip thermal desorption capability and was coated by electrodeposited gold as an adsorbent material. Experimental evaluations showed successful preconcentration of trace level of Propofol from a mixture containing several volatile organic compounds diluted in water-like solvent (1-propanol) and the efficient removal of non-polar compounds present in the mixture.
authors: VTMEMS Laboratory, Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. alfeeli@vt.edu
authors: Bassam
authors: B
authors: Alfeeli
authors: Mohammad A
authors: MA
authors: Zareian-Jahromi
authors: Masoud
authors: M
authors: Agah
mesh_terms: D000433:1-Propanol / Q000737:chemistry; D000327:Adsorption; D000777:Anesthetics / Q000494:pharmacology*; D004595:Electroplating; D018274:Electroporation; D004867:Equipment Design; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D008904:Miniaturization; D016343:Monitoring, Intraoperative / Q000295:instrumentation* / Q000379:methods; D055095:Optics and Photonics; D015742:Propofol / Q000494:pharmacology*; D012997:Solvents / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000777:Anesthetics; D012997:Solvents; D006046:Gold; D000433:1-Propanol; D015742:Propofol