Deuterium isotope effect on excited-state dynamics in an alternating GC oligonucleotide.
Isotope effects on the excited-state dynamics of single- and double-stranded GC-containing DNAs were studied by femtosecond transient absorption spectroscopy. A pronounced deuterium isotope effect was observed in alternating d(GC)(9).d(GC)(9), but none was seen in the nonalternating or single-stranded variations investigated. These findings demonstrate that an interstrand process involving proton-coupled electron transfer contributes to the excited-state dynamics in DNAs having an appropriate base sequence.
de La Harpe
Kimberly
K
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA.
Crespo-Hernández
Carlos E
CE
Kohler
Bern
B
D000042:Absorption; D020029:Base Pairing; D003903:Deuterium / Q000737:chemistry*; D020862:GC Rich Sequence; D007700:Kinetics; D009841:Oligonucleotides / Q000737:chemistry* / Q000235:genetics*
D009841:Oligonucleotides; D003903:Deuterium