title: Aggressive angiomyxoma of larynx: case report and literature review.
abstract: OBJECTIVE
  We report the second known case of aggressive angiomyxoma of the larynx.
  
  
  METHODS
  Case report and a review of the world literature concerning angiomyxoma of the larynx and recent advances in the immunohistochemical, cytogenic and clinical study of its female pelvic counterpart.
  
  
  RESULTS
  Aggressive angiomyxoma is a rare mesenchymal tumour originally thought only to occur in the female pelvis and peritoneum, or rarely in the male genital tract. A 47-year-old man presented with a one-month history of dysphonia. He was found to have a supraglottic mass on endoscopic examination, and underwent a laryngofissure approach excision biopsy and covering tracheostomy. Histological analysis showed a characteristic proliferation of spindle cells widely separated by loose, myxoid stroma with a prominent vascular component. Aggressive angiomyxoma was diagnosed.
  
  
  CONCLUSIONS
  To our knowledge, this is the second report in the world literature of aggressive angiomyxoma of the larynx. Comparison with the female pelvic counterpart facilitates diagnosis, aided by recent advances, and suggests that complete surgical excision with a wide margin is the treatment of choice.
authors: Department of Otolaryngology, The Leeds General Infirmary, UK. dsylvester@doctors.net.uk
authors: D C
authors: DC
authors: Sylvester
authors: S
authors: S
authors: Kortequee
authors: J W
authors: JW
authors: Moor
authors: C J
authors: CJ
authors: Woodhead
authors: K A
authors: KA
authors: Maclennan
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009232:Myxoma / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome