Clonally transmissible cancers in dogs and Tasmanian devils.
Tasmanian devil facial tumor disease (DFTD) and canine transmissible venereal tumor (CTVT) are the only known naturally occurring clonally transmissible cancers. These cancers are transmitted by the physical transfer of viable tumor cells that can be transplanted across histocompatibility barriers into unrelated hosts. Despite their common etiology, DFTD and CTVT have evolved independently and have unique life histories and host adaptations. DFTD is a recently emerged aggressive facial tumor that is threatening the Tasmanian devil with extinction. CTVT is a sexually transmitted tumor of dogs that has a worldwide distribution and that probably arose thousands of years ago. By contrasting the biology, molecular genetics and immunology of these two unusual cancers, I highlight the common and unique features of clonally transmissible cancers, and discuss the implications of clonally transmissible cancers for host-pathogen evolution.
Murchison
E P
EP
Cancer Genome Project, Wellcome Trust Sanger Institute, Cambridge, UK. elizabeth.murchison@sanger.ac.uk
D056704:Adaptive Immunity; D000818:Animals; D002999:Clone Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D004283:Dog Diseases / Q000235:genetics / Q000473:pathology* / Q000635:transmission; D004285:Dogs; D020022:Genetic Predisposition to Disease; D008394:Marsupialia; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*