Concurrent Guillain-Barré syndrome and myasthenia gravis: the first case in Taiwan.
The concurrent development of Guillain-Barré syndrome (GBS) and myasthenia gravis (MG) is rare. It has been associated with molecular mimicry between infectious agents and self-antigens. Such antibodies may show cross-reactions against both myelin proteins of peripheral nerves and acetylcholine receptors of neuromuscular junctions. Thymoma-associated multi-organ autoimmunity may also play a role in initiating autoimmune process. We present such a case with the concurrent development of GBS and MG.
Kung
Sheng-Ling
SL
Department of Neurology, Chung Shan Medical University Hospital, Taichung, Taiwan.
Su
Jang-Ming
JM
Tsai
Shin-Jei
SJ
Lu
Tsong-Ming
TM
Chen
Chiu-Mei
CM
D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000906:Antibodies / Q000097:blood; D004558:Electric Stimulation / Q000379:methods; D005260:Female; D020275:Guillain-Barre Syndrome / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007633:Keratins / Q000378:metabolism; D009157:Myasthenia Gravis / Q000150:complications* / Q000175:diagnosis; D009431:Neural Conduction / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D011950:Receptors, Cholinergic / Q000276:immunology; D013624:Taiwan; D014057:Tomography, X-Ray Computed / Q000379:methods
D000906:Antibodies; D011950:Receptors, Cholinergic; D007633:Keratins