title: Pilot canine investigation of the cardiopulmonary baroreflex control of ventricular contractility.
abstract: We performed a pilot investigation of the cardiopulmonary baroreflex control of ventricular contractility in two conscious dogs. We specifically measured spontaneous beat-to-beat hemodynamic variability before and after the administration of propranolol. We then identified the transfer function relating beat-to-beat fluctuations in central venous pressure (CVP) to maximal ventricular elastance (E(max)) to characterize the cardiopulmonary baroreflex control of ventricular contractility, while accounting for the influences of arterial blood pressure fluctuations on E(max) via the arterial baroreflex and heart rate fluctuations on E(max) via the force-frequency relation. Our major finding is that the cardiopulmonary baroreflex responds to an increase (decrease) in CVP by increasing (decreasing) E(max) via the beta-sympathetic nervous system.
authors: Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201 USA. javosala@hotmail.com
authors: Javier A
authors: JA
authors: Sala-Mercado
authors: Xiaoxiao
authors: X
authors: Chen
authors: Robert L
authors: RL
authors: Hammond
authors: Masashi
authors: M
authors: Ichinose
authors: Donal S
authors: DS
authors: O'Leary
authors: Ramakrishna
authors: R
authors: Mukkamala
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D004285:Dogs; D006321:Heart / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D006352:Heart Ventricles; D006439:Hemodynamics / Q000502:physiology; D008168:Lung / Q000502:physiology*; D008955:Models, Cardiovascular; D009119:Muscle Contraction; D009200:Myocardial Contraction / Q000502:physiology*; D010865:Pilot Projects; D013564:Sympathetic Nervous System; D014683:Vena Cava, Superior / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology