Mineralocorticoid receptor p.I180V polymorphism: association with body mass index and LDL-cholesterol levels.
OBJECTIVE
Aldosterone and the mineralocorticoid receptor (MR) play a major role in sodium balance and blood pressure control. They are also involved in adipocyte metabolism. The aim of this study was to analyze the association between the MR p.I180V polymorphism with hypertension and markers of cardiovascular risk.


METHODS
Case-control study nested within a cohort of 2063 subjects followed since birth to date. All subjects (age 23-25 yr old) from the entire cohort with systolic and diastolic hypertension (no.=126) were paired with 398 normotensive controls. MR p.I180V genotype association with anthropometric and biochemical markers of cardiometabolic risk was tested.


RESULTS
There was a significant association of the MR p.I180V genotype with body mass index (BMI) and LDL-cholesterol level (p<0.01). Hypertensive subjects carrying the polymorphic G allele (AG or GG genotypes) presented significantly higher BMI (30.0+/-6.0 vs 28.7+/-5.6 kg/m(2); p<0.01) and higher LDL-cholesterol (139.9+/-60.3 vs 109.9+/-35.5 mg/dl; p<0.01). The frequency of the polymorphism MR p.I180V was similar between hypertensive subjects and controls (p=0.15).


CONCLUSIONS
The MR p.I180V polymorphism seems to be associated with cardiovascular risk factors including BMI and LDL-cholesterol levels. This original in vivo finding reinforces the role of MR in adipocyte biology and in cardiovascular disease.
Fernandes-Rosa
F L
FL
Department of Puericulture and Pediatrics, School of Medicine of Ribeirao Preto, University of Sao Paulo, USP. Av Bandeirantes 3900, CEP 14049-900, Ribeirao Preto SP, Brazil.
Bueno
A C
AC
de Souza
R Molina
RM
de Castro
M
M
dos Santos
J Ernesto
JE
Foss
M C
MC
Zennaro
M-C
MC
Bettiol
H
H
Barbieri
M A
MA
Antonini
S R
SR
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D018161:Receptors, Mineralocorticoid / Q000235:genetics*; D012307:Risk Factors
D008078:Cholesterol, LDL; D018161:Receptors, Mineralocorticoid