title: Insertion of benzene rings into the amide bond: one-step synthesis of acridines and acridones from aryl amides.
abstract: Insertion of benzene rings into the amide bond using the reactive intermediate benzyne is described. Aromatic amides undergo smooth insertion when treated with O-triflatophenyl silane benzyne precursors, producing versatile aminobenzophenone products in good to excellent yield. The process is entirely metal-free and has been exemplified on the synthesis of biologically active acridones and acridines.
authors: School of Chemistry, University of Edinburgh, King's Buildings, West Mains Rd, Edinburgh EH9 3JJ, UK.
authors: Didier G
authors: DG
authors: Pintori
authors: Michael F
authors: MF
authors: Greaney