The role of formins in human disease.
Formins are a conserved family of proteins that play key roles in cytoskeletal remodeling. They nucleate and processively elongate non-branched actin filaments and also modulate microtubule dynamics. Despite their significant contributions to cell biology and development, few studies have directly implicated formins in disease pathogenesis. This review highlights the roles of formins in cell division, migration, immunity, and microvesicle formation in the context of human disease. In addition, we discuss the importance of controlling formin activity and protein expression to maintain cell homeostasis.
DeWard
Aaron D
AD
Laboratory of Cell Structure and Signal Integration, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
Eisenmann
Kathryn M
KM
Matheson
Stephen F
SF
Alberts
Arthur S
AS
D000595:Amino Acid Sequence; D000818:Animals; D002465:Cell Movement / Q000502:physiology; D048749:Cytokinesis / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism; D004194:Disease; D004195:Disease Models, Animal; D005326:Fetal Proteins / Q000235:genetics / Q000378:metabolism; D000080865:Formins; D006801:Humans; D007107:Immune System / Q000502:physiology; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment
D005326:Fetal Proteins; D000080865:Formins; D008840:Microfilament Proteins; D009687:Nuclear Proteins