Uterine adenocarcinoma with prominent desmoplasia in a geriatric miniature pig.
A 10-year-old miniature sow was died, showing inappetence and weight loss. Grossly, neoplastic enlargement of the uterus was found. Histopathologically, the lesions consisted of acinar, ductular and cystic proliferations of mono- and multilayered epithelial cells; these cells reacted immunohistochemically strongly with three different cytokeratin antibodies, and occasionally to vimentin. Myofibroblastic desmoplastic cells, positive to alpha-smooth muscle actin, were present among neoplastic cells. Metastatic lesions were seen in the lungs and liver. Based on these findings, a diagnosis of uterine adenocarcinoma with marked desmoplasia was made. This case is the second report of uterine adenocarcinoma in the miniature pig.
Golbar
Hossain
H
Laboratory of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku Ourai Kita, Izumisano, Osaka 598-8531, Japan.
Izawa
Takeshi
T
Kuwamura
Mitsuru
M
Ito
Shu
S
Yamate
Jyoji
J
D000230:Adenocarcinoma / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000473:pathology*; D013556:Swine, Miniature; D014594:Uterine Neoplasms / Q000473:pathology / Q000662:veterinary*