title: Lichen metabolites modulate hydrogen peroxide and nitric oxide in mouse macrophages.
abstract: The activities of perlatolic acid (1), atranorin (2), and lecanoric acid (3) and their derivatives, such as orsellinates and beta-methyl orsellinates obtained by alcoholysis, were assessed for stimulation of the release of hydrogen peroxide and nitric oxide in cultures of peritoneal macrophage cells from mice. The hydrogen peroxide production was estimated by oxidation of phenol red, while the Griess reagent was used to determine the nitric oxide production. 1 and 4-methoxy-ethyl orsellinate (XVII) were the compounds that induced the greatest release of H2O2, whereas n-pentyl orsellinate (IV), iso-propyl orsellinate (V), sec-butyl orsellinate (VI), and XVII induced a small release of NO. These results indicate that lichen products and their derivatives have potential immune-modulating activities.
authors: UNESP-São Paulo State University, Faculdade de Ciências Farmacêuticas, C. Postal 502, 14801-902, Araraquara, SP, Brazil. carlosiz@fcfar.unesp.br
authors: Iracilda Z
authors: IZ
authors: Carlos
authors: Marcela B
authors: MB
authors: Quilles
authors: Camila B A
authors: CB
authors: Carli
authors: Danielle C G
authors: DC
authors: Maia
authors: Fernanda P
authors: FP
authors: Benzatti
authors: Thiago I B
authors: TI
authors: Lopes
authors: Aline S
authors: AS
authors: Gianini
authors: Rosenei L
authors: RL
authors: Brum
authors: Wagner
authors: W
authors: Vilegas
authors: Lourdes C
authors: LC
authors: dos Santos
authors: Neli K
authors: NK
authors: Honda
mesh_terms: D000818:Animals; D006861:Hydrogen Peroxide / Q000378:metabolism*; D008011:Lichens / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism*; D010936:Plant Extracts / Q000378:metabolism*
chemical_list: D010936:Plant Extracts; D009569:Nitric Oxide; D006861:Hydrogen Peroxide