[New possibilities of the extremity revascularization in chronic ischemia: induction of angiogenesis by the bone marrow aspirate autotransplantation in patients with arteriosclerosis obliterans in the vessels of the lower extremities].
In 55 patients, suffering obliterating atherosclerosis and chronic arterial insufficiency, there was accomplished autotransplantation of the bone marrow aspirate (ABMA) because of impossibility of conduction of direct revascularization of the lower extremity in inoperable or operable in question affection of the distal vascular bed, as a monomethod or in simultant fashion with reconstructive operations on proximal segments of vascular bed or using the other methods of indirect revascularization. After the operation in 63.1% of patients it appeared possible to preserve the "lean on" function of the lower extremity in early period and in 52.6%--in the remote period. The ABMA method application had permitted to correct microhemodynamical disorders by stimulation of angiogenesis and development of collateral blood flow in patients, suffering chronic ischemia of lower extremities, especially in the critical ischemia stage.
Kirimov
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D000328:Adult; D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D016026:Bone Marrow Transplantation / Q000379:methods*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D007866:Leg / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D008297:Male; D008833:Microcirculation / Q000502:physiology; D008875:Middle Aged; D009336:Necrosis; D018919:Neovascularization, Physiologic; D012720:Severity of Illness Index; D014182:Transplantation, Autologous; D016896:Treatment Outcome