title: The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline.
abstract: OBJECTIVE
  Do prophylactic anticonvulsants decrease the risk of seizure in patients with metastatic brain tumors compared with no treatment?
  
  
  METHODS
  These recommendations apply to adults with solid brain metastases who have not experienced a seizure due to their metastatic brain disease.
  
  
  CONCLUSIONS
  Level 3 For adults with brain metastases who have not experienced a seizure due to their metastatic brain disease, routine prophylactic use of anticonvulsants is not recommended. Only a single underpowered randomized controlled trial (RCT), which did not detect a difference in seizure occurrence, provides evidence for decision-making purposes.
authors: Department of Neurology, Henry Ford Health System, Detroit, MI, USA.
authors: Tom
authors: T
authors: Mikkelsen
authors: Nina A
authors: NA
authors: Paleologos
authors: Paula D
authors: PD
authors: Robinson
authors: Mario
authors: M
authors: Ammirati
authors: David W
authors: DW
authors: Andrews
authors: Anthony L
authors: AL
authors: Asher
authors: Stuart H
authors: SH
authors: Burri
authors: Charles S
authors: CS
authors: Cobbs
authors: Laurie E
authors: LE
authors: Gaspar
authors: Douglas
authors: D
authors: Kondziolka
authors: Mark E
authors: ME
authors: Linskey
authors: Jay S
authors: JS
authors: Loeffler
authors: Michael
authors: M
authors: McDermott
authors: Minesh P
authors: MP
authors: Mehta
authors: Jeffrey J
authors: JJ
authors: Olson
authors: Roy A
authors: RA
authors: Patchell
authors: Timothy C
authors: TC
authors: Ryken
authors: Steven N
authors: SN
authors: Kalkanis
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000150:complications* / Q000556:secondary; D016208:Databases, Factual / Q000706:statistics & numerical data; D019317:Evidence-Based Medicine; D006801:Humans; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D012640:Seizures / Q000209:etiology* / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants