The effect of intraperitoneal administration of zinc aspartate on myringosclerosis in perforated tympanic membranes of rats.
OBJECTIVE
The objective of the present study was to determine the effect of zinc aspartate on myringosclerosis in perforated rat tympanic membrane.


METHODS
Fifteen Sprague-Dawley rats were randomly divided into three groups each containing five rats. Automicroscopic examinations were performed and then all rats were bilaterally myringotomized. Group 1 received no treatment. Group 2 was treated with intraperitoneal injection of physiological saline and group 3 with intraperitoneal injection of zinc aspartate. Tympanic bullas were harvested after 20 days. Histopathological evaluation was carried out under the light microscope.


RESULTS
When the groups were compared in the light of the myringosclerotic findings, while there was no significant difference between group 1 and 2 (p=1.00), it was found that there were significant differences between group 1 and 3, and between group 2 and 3 (p<0.03).


CONCLUSIONS
It appears that zinc aspartat treatment has beneficial effects on prevention or retardation of the development of myringosclerosis, but further studies are needed to clarify this effect.
Yildirim
Ilhami
I
Department of Otolaryngology, Medicine Faculty of Sütçü Imam University, Kahramanmaraş, Turkey. yildirimilhami@hotmail.com
Ciralik
Harun
H
Okur
Erdoğan
E
Aydoğan
Barlas
B
Kiliç
M Akif
MA
D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D009225:Myringoplasty / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D012598:Sclerosis / Q000139:chemically induced / Q000473:pathology; D014432:Tympanic Membrane / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D018058:Tympanic Membrane Perforation / Q000473:pathology / Q000601:surgery*; D015032:Zinc / Q000494:pharmacology
D001224:Aspartic Acid; D015032:Zinc