title: Determination of phthalates in diet and bedding for experimental animals using gas chromatography-mass spectrometry.
abstract: We have developed a gas chromatography-mass spectrometry method to measure five phthalates (dibutyl phthalate, butylbenzyl phthalate, di-2-ethylhexyl phthalate, diisooctyl phthalate, and diisononyl phthalate) in diets and beddings for experimental animals. The recoveries from diets and beddings spiked with five phthalates were 98.8%-148% with coefficients of variation of 0.4%-7.8% for diets and 94.7%-146% with coefficients of variation of 1.0%-5.0% for beddings. We analyzed commercial animal diets and beddings, and found that the levels of phthalates varied from sample to sample; the concentrations of five phthalates were 141-1,410 ng/g for diets and 20.5-7,560 ng/g for beddings.
authors: Department of Toxicology, Aichi Prefectural Institute of Public Health, 7-6 Nagare, Tsuji-machi, Kita-ku, Nagoya 462-8576, Japan. fumio@ipc-tokai.or.jp
authors: Fumio
authors: F
authors: Kondo
authors: Masanao
authors: M
authors: Okumura
authors: Hisao
authors: H
authors: Oka
authors: Hiroyuki
authors: H
authors: Nakazawa
authors: Shun-Ichiro
authors: S
authors: Izumi
authors: Tsunehisa
authors: T
authors: Makino
mesh_terms: D000388:Air / Q000032:analysis; D000393:Air Pollutants / Q000032:analysis; D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D000830:Animals, Laboratory; D002138:Calibration; D004032:Diet; D005506:Food Contamination; D008401:Gas Chromatography-Mass Spectrometry; D010795:Phthalic Acids / Q000032:analysis*; D012015:Reference Standards; D012377:Rodentia; D014867:Water / Q000032:analysis; D014873:Water Pollutants / Q000032:analysis
chemical_list: D000393:Air Pollutants; D010795:Phthalic Acids; D014873:Water Pollutants; D014867:Water