The effects of salvianolic acid B from radix salvia miltiorrhizae on the oral pharmacokinetics of metoprolol and metoprolol acid in rats.
The present study aimed to investigate the effects of salvianolic acid B (SalB) isolated from Radix Salvia miltiorrhizae on the oral pharmacokinetics of metoprolol (MET) and metoprolol acid (META) in rats. The pharmacokinetic parameters of MET and META were measured after oral (15 mg/kg) administration of MET in rats in the presence and absence of SalB. Compared to the control given MET alone, with the concurrent administration of SalB (50 mg/kg), the AUC and C(max) of MET increased by 51.7% and 27.7%, and the AUC and C(max) of META decreased by 26.5% and 19.6%, respectively. With the presence of SalB, the metabolic ratio was markedly decreased by 50.8%. However, no significant changes were observed in the pharmacokinetic parameters of SalB when it was combined with MET.
Wan
Ren-zhong
RZ
Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Shenyang, China.
Zhou
Mao-jin
MJ
Liu
Chang-xiao
CX
D000818:Animals; D019540:Area Under Curve; D001572:Benzofurans / Q000494:pharmacology*; D005260:Female; D008297:Male; D008790:Metoprolol / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D053630:Depsides
D001572:Benzofurans; D008790:Metoprolol; C469429:4-(2-hydroxy-3-isopropylaminopropoxy)-phenylacetic acid; C076944:salvianolic acid B; D053630:Depsides