title: Clinicopathological analysis of Borrmann type IV gastric cancer.
abstract: OBJECTIVE
  Borrmann type IV gastric cancer is often diagnosed only at an advanced stage, resulting in a prognosis poor. We performed a retrospective study of the clinical characteristics of Borrmann type IV gastric cancer and the prognostic factors affecting the survival rate in such patients.
  
  
  METHODS
  Of 4,063 patients with all gastric cancers, 370 (9%) with Borrmann type IV gastric cancer were analyzed.
  
  
  RESULTS
  The clinical characteristics of these patients included a higher incidence rate in young females, and higher rates of serosa exposure, metastasis to lymph nodes and early peritoneal dissemination. Of patients presenting with peritoneal seeding, those resected had a higher survival rate than those that were not. A univariate analysis showed that the prognostic factors affecting the survival rate following a curative resection were the location, occupied area and depth of the primary tumor, as well as the presence of lymph node metastasis and the tumor stage. A multivariate analysis indicated that the tumor location and stage were significant independent prognostic factors after a curative resection for Borrmann type IV gastric cancer.
  
  
  CONCLUSIONS
  In conclusion, the early diagnosis and treatment of patients with Borrmann type IV gastric cancer are essential for the better survival of these patients. Even in patients with advanced tumors, a noncurative palliative resection may improve the prognosis.
authors: Department of Surgery, Ulsan University College of Medicine, Seoul, Korea. jhyook@amc.seoul.kr
authors: Jeong Hwan
authors: JH
authors: Yook
authors: Sung Tae
authors: ST
authors: Oh
authors: Byung Sik
authors: BS
authors: Kim