title: Cardiac ablation via electroporation.
abstract: Thermal-based ablation for the treatment of arrhythmias is known to cause issues (e.g. heat loss due to blood perfusion, mechanical damage of the tissue from excessive heat, etc.) that hamper the success of the treatment. A novel technique termed "electroporation" is a process that leads to pore formation in cell membranes. These pores may cause cellular death without inducing negative thermal effects. We successfully developed a system, tools, and methodology to operate this new ablation technique. Preliminary in vivo acute animal studies (ovine) suggest distinct lesion morphology. High transmurality success rates also suggest the possibility of applying this new ablation modality to cardiac ablation. A long term study confirming lesion durability is necessary to warrant the successful adoption of this technique.
authors: CardioVascular division of Medtronic, Inc., Fridley, MN 55432, USA. jinback.hong@medtronic.com
authors: Jinback
authors: J
authors: Hong
authors: Mark T
authors: MT
authors: Stewart
authors: Daniel S
authors: DS
authors: Cheek
authors: David E
authors: DE
authors: Francischelli
authors: Nicole
authors: N
authors: Kirchhof
mesh_terms: D000818:Animals; D017115:Catheter Ablation / Q000379:methods*; D003198:Computer Simulation; D004562:Electrocardiography / Q000379:methods; D004594:Electrophysiology / Q000379:methods; D018274:Electroporation; D004867:Equipment Design; D006321:Heart / Q000502:physiology*; D006358:Hot Temperature; D007477:Ions; D009200:Myocardial Contraction; D011667:Pulmonary Veins / Q000473:pathology; D012756:Sheep; D013696:Temperature; D014684:Venae Cavae / Q000473:pathology
chemical_list: D007477:Ions