Emerging applications of stereotactic radiotherapy in head and neck cancer.
Advances in the management of locally advanced head and neck cancer (HNC) have been focused on treatment intensification, including concomitant chemoradiotherapy, biological agents, and combining surgery with chemoradiotherapy. Despite these improvements, locoregional recurrence still constitutes the main pattern of treatment failure. As improvements in radiotherapy delivery and image-guided therapy have come to fruition, the principles of stereotactic radiosurgery are now being applied to extracranial sites, leading to stereotactic body radiotherapy. This article focuses on the emerging evidence for the use of stereotactic body radiotherapy for treatment of HNC as a boost after conventional external-beam radiotherapy, and also as reirradiation in recurrent or second primary HNC.
Truong
Minh Tam
MT
Department of Radiation Oncology, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA. mitruong@bu.edu
Grillone
Gregory
G
Tschoe
Christine
C
Chin
Lawrence
L
Kachnic
Lisa Ann
LA
Jalisi
Scharukh
S
D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D006801:Humans; D016634:Radiosurgery / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D025321:Surgery, Computer-Assisted / Q000379:methods; D016896:Treatment Outcome