title: Cost-effectiveness of enoxaparin compared with unfractionated heparin in ST elevation myocardial infarction patients undergoing pharmacological reperfusion: a Canadian analysis of the Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment - Thrombolysis in Myocardial Infarction (ExTRACT-TIMI) 25 trial.
abstract: OBJECTIVE
  To evaluate the cost-effectiveness of enoxaparin versus unfractionated heparin in conjunction with fibrinolysis in ST elevation myocardial infarction patients within Canada.
  
  
  METHODS
  Based on the Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment - Thrombolysis in Myocardial Infarction (ExTRACT-TIMI) 25 trial, a model was created to analyze the cost-effectiveness of enoxaparin compared with unfractionated heparin in conjunction with fibrinolysis among ST elevation myocardial infarction patients within Canada. Clinical outcomes were derived from published results of the main trial. Resource use costs were first assessed based on United States Diagnosis-Related Group values for hospitalizations and Current Procedural Terminology codes for outpatient visits and tests. Both were then converted using Canadian local costs. Survival and life expectancy were estimated from Framingham survival data. The incremental cost-effectiveness ratio was expressed as cost per life year gained.
  
  
  RESULTS
  Through 30 days after random assignment, the primary composite end point favoured the enoxaparin group over the unfractionated heparin group (death or recurrent myocardial infarction rate 9.9% versus 12.0%, P<0.001), and was associated with a modest increased cost of $169.50 ($8,757.00 versus $8,587.50, respectively). Life years gained as a result of treatment with enoxaparin was increased by 0.11 years (P<0.05). Enoxaparin was found to be cost-effective, as indicated by an incremental cost-effectiveness ratio of $4,930 with a 99% probability of costing less than $20,000.
  
  
  CONCLUSIONS
  Although associated with modest increased direct medication costs, enoxaparin following fibrinolysis improved the clinical efficacy in STEMI patients and increased the life years gained.
authors: University of Alberta and Mazankowski Alberta Heart Institute, Edmonton, Canada. rwelsh@cha.ab.ca
authors: Rober C
authors: RC
authors: Welsh
authors: Luc
authors: L
authors: Sauriol
authors: Zugui
authors: Z
authors: Zhang
authors: Paul
authors: P
authors: Kolm
authors: Willian S
authors: WS
authors: Weintraub
authors: Pierre
authors: P
authors: Theroux
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000191:economics*; D002170:Canada; D003362:Cost-Benefit Analysis; D004311:Double-Blind Method; D017984:Enoxaparin / Q000008:administration & dosage / Q000191:economics*; D005260:Female; D005342:Fibrinolysis; D017048:Health Care Costs / Q000706:statistics & numerical data; D006493:Heparin / Q000008:administration & dosage / Q000191:economics*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy / Q000191:economics*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D006493:Heparin