Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade.
Genome sequences of human rhinoviruses (HRV) have primarily been from stocks collected in the 1960s, with genomes and phylogeny of modern HRVs remaining undefined. Here, two modern isolates (hrv-A101 and hrv-A101-v1) collected approximately 8 years apart were sequenced in their entirety. Incorporation into our full-genome HRV alignment with subsequent phylogenetic network inference indicated that these represent a unique HRV-A, localized within a distinct divergent clade. They appear to have resulted from recombination of the hrv-65 and hrv-78 lineages. These results support our contention that there are unrecognized distinct HRV-A strains, and that recombination is evident in currently circulating strains.
Rathe
Jennifer A
JA
Department of Medicine, University of Maryland School of Medicine, 20 Penn Street, HSF-II, Room S-114, Baltimore, MD 21201, USA.
Liu
Xinyue
X
Tallon
Luke J
LJ
Gern
James E
JE
Liggett
Stephen B
SB
D019143:Evolution, Molecular; D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D010850:Picornaviridae Infections / Q000821:virology*; D012141:Respiratory Tract Infections / Q000821:virology*; D012229:Rhinovirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification