Management of schizophrenia with substance use disorders.
Around 50% of patients with schizophrenia develop a co-occurring substance use disorder involving alcohol or illicit substances at some time during their lives. The comorbid substance abuse will markedly affect the course of illness of schizophrenia. In this article, the authors review the epidemiology, theories of causation, effect on the course of illness, and treatment of co-occurring schizophrenia and substance use disorder.
Lybrand
Janice
J
Department of Psychiatry, Philadelphia VA Medical Center, Philadelphia, PA 19104, USA. janice.lybrand@va.gov
Caroff
Stanley
S
D014150:Antipsychotic Agents / Q000627:therapeutic use*; D017831:Diagnosis, Dual (Psychiatry) / Q000523:psychology; D004221:Disulfiram; D006801:Humans; D011613:Psychotherapy / Q000379:methods; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy / Q000628:therapy*; D012565:Schizophrenic Psychology; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000628:therapy
D014150:Antipsychotic Agents; D004221:Disulfiram