title: Scalp acupuncture effects of stroke studied with magnetic resonance imaging: different actions in the two stroke model rats.
abstract: BACKGROUND
  Scalp acupuncture (SA) therapy on strokes has been empirically established and widely used in clinics in China. The evidence from clinical studies suggests that SA produces significant benefits for some patients with stroke.
  
  
  METHODS
  The effect of scalp acupuncture was studied using MRI for two different stroke models: spontaneously hypertensive stroke-prone (SHR-SP) rats and rats with transiently induced focal cerebral ischaemia by middle cerebral artery occlusion for 2 h (MCAO rats).
  
  
  RESULTS
  Stroke onset in SHR-SP rats was characterised by a development of vasogenic oedema without any appearance of cytotoxic oedema. Scalp acupuncture reduced rapidly neurological dysfunction in SHR-SP rats and reduced the volume of the vasogenic oedema during the same period. In contrast, in MCAO rats, focal cerebral ischaemia caused an immediate development of cytotoxic oedema without any appearance of vasogenic oedema. Vasogenic oedema developed after reperfusion. Scalp acupuncture had no significant effects on the cytotoxic oedema, vasogenic oedema or neurological dysfunction of the MCAO rats within the time span examined.
  
  
  CONCLUSIONS
  Scalp acupuncture had a rapid and strong effect on neurological dysfunction only in the hypertensive stroke-model by reducing the vasogenic oedema. Our results suggest that, if there are similar underlying mechanisms in human strokes, scalp acupuncture may be more beneficial for patients with strokes of hypertension-caused vasogenic origin than ischaemic origin.
authors: Institute for Enzyme Research, Tokushima University, Tokushima 770-8503, Japan. iinoue@ier.tokushima-u.ac.jp
authors: Isao
authors: I
authors: Inoue
authors: Mari
authors: M
authors: Fukunaga
authors: Keiko
authors: K
authors: Koga
authors: Hong-Du
authors: HD
authors: Wang
authors: Makoto
authors: M
authors: Ishikawa
mesh_terms: D015669:Acupuncture Points; D015670:Acupuncture Therapy / Q000379:methods*; D000818:Animals; D001921:Brain / Q000503:physiopathology; D002545:Brain Ischemia / Q000150:complications / Q000628:therapy*; D002681:China; D004195:Disease Models, Animal; D006973:Hypertension / Q000150:complications; D020244:Infarction, Middle Cerebral Artery / Q000145:classification* / Q000209:etiology / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D051381:Rats; D011918:Rats, Inbred SHR; D012535:Scalp