[Association of genetic polymorphism in phenylethanolamine-N-methyl transferase with essential hypertension in Changsha Han people].
OBJECTIVE
To investigate the association of phenylethanolamine-N-methyl transferase (PNMT) G-390A genetic polymorphism with risk of essential hypertension (EH) in Changsha Han people.


METHODS
A case-control association study was performed in 400 patients with essential hypertension (EH) and 388 normotensive subjects. PNMT G-390A was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-FRLP).


RESULTS
The genotype frequencies for the -390 GG, GA, and AA were 39.3%,50.0%, and 10.8%, respectively in EH patients, and were 43.6%,45.6%, and 10.8%, in normal subjects. No significant difference in either genotypic frequency (P=0.433) or allele frequency (P=0.378) of PNMT G-390A between EH patients and normals was observed. When by gender, there was significant difference in genotypic frequency (P<0.05) and allele frequency (P=0.046) of G-390A polymorphism between EH patients and normals in the male, but not in the female (P>0.05).


CONCLUSIONS
PNMT G-390A polymorphism is possibly associated with EH risk in male Chinese Han population in Changsha.
Chen
An
A
Department of Cardiovasology, Central South University, Changsha 410008, China.
Chen
Xiaoping
X
Shi
Ruizheng
R
Guo
Yijie
Y
Chen
Lujia
L
Xie
Mingxuan
M
Yang
Tianlun
T
Zhang
Guogang
G
D000328:Adult; D000368:Aged; D001483:Base Sequence; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010625:Phenylethanolamine N-Methyltransferase / Q000235:genetics*; D011110:Polymorphism, Genetic; D012737:Sex Factors
D010625:Phenylethanolamine N-Methyltransferase