IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation.
IL-23/IL-17 axis is an important regulator in various inflammatory diseases. However, the role of IL-23 in allergic airway inflammation is not well understood. In this study, we show that in an allergen-induced asthma model, mice with transgenic overexpression of IL-23R exhibited increased airway infiltration of eosinophils and Th2 cytokine production, whereas those deficient in IL-23 displayed reduced airway inflammation. In vitro, IL-23-IL-23R signaling promoted GATA-3 expression and enhanced Th2 cytokine expression. Conversely, in the absence of this signal, Th2 cell differentiation was partially inhibited. Therefore, IL-23 signaling may regulate allergic asthma through modulation of Th2 cell differentiation.
Peng
Juan
J
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA.
Yang
Xuexian O
XO
Chang
Seon Hee
SH
Yang
Jiong
J
Dong
Chen
C
D056704:Adaptive Immunity / Q000276:immunology; D000485:Allergens / Q000494:pharmacology; D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000503:physiopathology*; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D016764:Cell Polarity / Q000235:genetics / Q000276:immunology; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D004195:Disease Models, Animal; D050990:GATA3 Transcription Factor / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics / Q000276:immunology; D006801:Humans; D053759:Interleukin-23 / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D018123:Receptors, Interleukin / Q000235:genetics; D012137:Respiratory System / Q000276:immunology* / Q000503:physiopathology*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology* / Q000378:metabolism; D015854:Up-Regulation / Q000276:immunology
D000485:Allergens; D050990:GATA3 Transcription Factor; C494748:Gata3 protein, mouse; D053759:Interleukin-23; D018123:Receptors, Interleukin; C528688:interleukin-23 receptor, mouse