title: Miltefosine treatment of Leishmania major infection: an observational study involving Dutch military personnel returning from northern Afghanistan.
abstract: In a retrospective, observational study involving 34 patients with Leishmania major infection, 31 of whom had experienced unsuccessful treatment with intralesional antimony (ilSb(v)), miltefosine proved effective. Thirty patients experienced cure after receipt of miltefosine, 3 after receipt of additional ilSb(v), and 1 after 28 daily intravenous injections of antimony. Temporary diminution of ejaculate volume was reported by 21 patients.
authors: Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS and Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. p.p.vanthiel@amc.nl
authors: P P A M
authors: PP
authors: van Thiel
authors: T
authors: T
authors: Leenstra
authors: P A
authors: PA
authors: Kager
authors: H J
authors: HJ
authors: de Vries
authors: M
authors: M
authors: van Vugt
authors: W F
authors: WF
authors: van der Meide
authors: A
authors: A
authors: Bart
authors: J E
authors: JE
authors: Zeegelaar
authors: A
authors: A
authors: van der Sluis
authors: H D F H
authors: HD
authors: Schallig
authors: T
authors: T
authors: van Gool
authors: W R
authors: WR
authors: Faber
authors: P J
authors: PJ
authors: de Vries
mesh_terms: D000328:Adult; D000346:Afghanistan; D005260:Female; D006801:Humans; D018320:Leishmania major / Q000302:isolation & purification*; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D009426:Netherlands; D010767:Phosphorylcholine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012189:Retrospective Studies; D014195:Travel; D016896:Treatment Outcome
chemical_list: D010767:Phosphorylcholine; C039128:miltefosine