Organically modified MCM-type material preparation and its usage in controlled amoxicillin delivery.
MCM-41 was grafted with 3-aminopropyl trimethoxysilane (APTMS), 3-chloropropyltriethoxysilane (CPTMS) to give organic group modified samples, and l-tryptophane was covalently immobilized onto organic samples to improve the physicochemical properties of mesoporous silica to controlled amoxicillin delivery. Samples were characterized by X-ray diffraction (XRD), N(2) adsorption-desorption isotherms and Fourier transform infrared (FT-IR) spectroscopy, and characterized results demonstrated that organic groups were successfully grafted onto the samples. The results of amoxicillin release exhibited that 12.9wt% and 33.0wt% impregnated amoxicillin could be released from the post-grafting MCM-41 with APTMS and pure MCM-41 after 24h, however, 41.0wt% impregnated amoxicillin could be released from the post-grafting MCM-41 with CPTMS after 24h. When the samples modified with APTMS and CPTMS were further grafted by l-tryptophane, the slower drug release rate was achieved over samples with l-tryptophane immobilization. The release profiles of all samples indicated that the amoxicillin release was mainly regulated by the diffusion mechanism.
Li
Zhenhuan
Z
School of Materials and Engineering, Tianjin Key Lab of Fiber Modification & Functional Fiber, Tianjin Polytechnic University, Tianjin 300160, China. Zhenhuanli1975@yahoo.com.cn
Su
Kunmei
K
Cheng
Bowen
B
Deng
Yanchao
Y
D000658:Amoxicillin / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004058:Diffusion; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D016062:Porosity; D011437:Propylamines / Q000737:chemistry; D012821:Silanes / Q000737:chemistry; D012822:Silicon Dioxide / Q000138:chemical synthesis / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014364:Tryptophan / Q000737:chemistry; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D004337:Drug Carriers; C509968:MCM-41; D011437:Propylamines; D012821:Silanes; C088294:3-aminopropyltrimethoxysilane; D012822:Silicon Dioxide; D000658:Amoxicillin; D014364:Tryptophan; C071717:trimethoxysilane