Applications of high content screening in life science research.
Over the last decade, imaging as a detection mode for cell based assays has opened a new world of opportunities to measure "phenotypic endpoints" in both current and developing biological models. These "high content" methods combine multiple measurements of cell physiology, whether it comes from sub-cellular compartments, multicellular structures, or model organisms. The resulting multifaceted data can be used to derive new insights into complex phenomena from cell differentiation to compound pharmacology and toxicity. Exploring the major application areas through review of the growing compendium of literature provides evidence that this technology is having a tangible impact on drug discovery and the life sciences.
Zock
Joseph M
JM
Thermo Fisher Scientific, 100 Technology Dr, Pittsburgh, PA 15219, USA. joe.zock@thermofisher.com
D000818:Animals; D001690:Biological Science Disciplines / Q000379:methods*; D055808:Drug Discovery / Q000379:methods; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D012107:Research Design