Human telomeric G-quadruplex: structures of DNA and RNA sequences.
Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design. This minireview describes the structural diversity or conservation of DNA and RNA human telomeric G-quadruplexes, discusses structural views on targeting these G-quadruplexes and presents some future challenges for structural studies.
Phan
Anh Tuân
AT
Division of Physics & Applied Physics, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore. phantuan@ntu.edu.sg
D004247:DNA / Q000737:chemistry*; D016503:Drug Delivery Systems; D054856:G-Quadruplexes; D006801:Humans; D008954:Models, Biological; D012313:RNA / Q000737:chemistry*; D016615:Telomere / Q000737:chemistry*
D012313:RNA; D004247:DNA