[Selective pituitary resistance to thyroid hormone in a patient treated with amiodarone].
Selective pituitary resistance to thyroid hormones is a syndrome that involves inadequate response of thyroid-stimulating hormone to changes in thyroid hormones. Unlike generalized resistance syndromes, this entity produces central hyperthyroidism and clinical thyrotoxicosis. Sometimes the disease may not be properly diagnosed and is treated with drugs with harmful effects on the thyroid, such as amiodarone, hampering diagnosis and possibly exacerbating the disorder. The treatment of this condition can be symptomatic, based on control of tachycardia and anxiety, or etiological, acting on the pituitary to regulate thyrotropin secretion or on the thyroid gland to control thyroid hormone production. We report the case of a patient with pituitary resistance to thyroid hormone, who was treated with amiodarone to control paroxysmal atrial fibrillation.
Gómez
Juan José López
JJ
Sección de Endocrinología y Nutrición, Complejo Asistencial de León, León, España. jjlopez161282@hotmail.com
Pomar
María D Ballesteros
MD
Casariego
Alfonso Vidal
AV
Rodríguez
Isidoro Cano
IC
D000638:Amiodarone / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D025461:Feedback, Physiological / Q000187:drug effects; D006042:Goiter / Q000150:complications* / Q000503:physiopathology / Q000532:radiotherapy; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007453:Iodide Peroxidase / Q000037:antagonists & inhibitors; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010903:Pituitary Gland, Anterior / Q000503:physiopathology*; D013961:Thyroid Gland / Q000187:drug effects; D013963:Thyroid Hormones / Q000097:blood; D013971:Thyrotoxicosis / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D013972:Thyrotropin / Q000502:physiology*; D013973:Thyrotropin-Releasing Hormone / Q000097:blood
D000889:Anti-Arrhythmia Agents; D007457:Iodine Radioisotopes; D013963:Thyroid Hormones; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D007453:Iodide Peroxidase; D000638:Amiodarone