Production of a new type of amidepsine with a sugar moiety by static fermentation of Humicola sp. FO-2942.
Static fermentation of amidepsine-producing fungus Humicola sp. FO-2942 led to the production of six new amidepsines, including a new type of glycosylated congener. Non-glycosylated amidepsine J inhibited both human diacylglycerol acyltransferases 1 (DGAT1) and DGAT2 with the same IC(50) value of 40 muM, whereas glycosylated amidepsines F to I showed very weak inhibitory activity against DGAT1 and DGAT2.
Inokoshi
Junji
J
Graduate School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
Takagi
Yoichi
Y
Uchida
Ryuji
R
Masuma
Rokuro
R
Omura
Satoshi
S
Tomoda
Hiroshi
H
D001203:Ascomycota / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D051048:Diacylglycerol O-Acyltransferase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D005285:Fermentation; D006801:Humans; D062385:Hydroxybenzoates / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure
D004791:Enzyme Inhibitors; D062385:Hydroxybenzoates; D051048:Diacylglycerol O-Acyltransferase