IgA nephropathy presenting with renal failure and pulmonary hemorrhage.
Pulmonary renal syndromes are unusual, but frequently life-threatening manifestations of a distinct group of disorders in the pediatric age group. Although IgA nephropathy is a common cause of hematuria, it is an extremely rare cause of pulmonary renal syndrome, causing high mortality, and has mostly been reported in adult patients. We describe the youngest patient with this presentation reported to date, a 14-year-old male, who presented with end stage renal disease and pulmonary hemorrhage and was found to have IgA nephropathy by renal biopsy and pulmonary capillaritis by open lung biopsy. His lung disease was successfully treated with immunosuppressive medications. Despite this being a rare manifestation of IgA nephropathy, clinicians need to be aware of this presentation as it is potentially fatal, but amenable to aggressive immunosuppression.
Srivaths
Poyyapakkam
P
Department of Pediatrics Renal Section, Baylor College of Medicine, MC 3-2482, 6621 Fannin St, Houston, TX 77030-2399, USA.
Dishop
Megan K
MK
Elidemir
Okan
O
Eldin
Karen
K
Browne
Lorna
L
Elenberg
Ewa
E
D058186:Acute Kidney Injury / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006470:Hemorrhage / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D011650:Pulmonary Alveoli / Q000473:pathology; D006435:Renal Dialysis; D014057:Tomography, X-Ray Computed
D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone