title: Necrotizing fasciitis of the face: a life-threatening condition.
abstract: Necrotizing fasciitis (NF) is a highly aggressive infectious process, polymicrobial in nature, involving soft tissues with a high risk of rapid spread through superficial and deep fascial planes and muscular layers. Cervical NF is quite rare, is mostly of odontogenic origin, and may be complicated by descendant mediastinitis with a very high mortality rate. Systemic conditions impairing the patient's immune competence, such as diabetes, may play a predisposing role. An effective treatment strategy includes prompt diagnosis (clinical findings, local microbiological tests, blood culture and, if deemed necessary, histopathology), broad-spectrum antibiotic therapy as early as possible which should be later adjusted according to antibiogram results, stabilization of vital functions and, if possible, elimination/ treatment of predisposing factors. This paper describes a complex and emblematic case.
authors: Department of Internal Medicine, University Hospital of Palermo, Palermo, Italy.
authors: Ilenia
authors: I
authors: Pepe
authors: Lucio
authors: L
authors: Lo Russo
authors: Valentina
authors: V
authors: Cannone
authors: Anna
authors: A
authors: Giammanco
authors: Fortunato
authors: F
authors: Sorrentino
authors: Domenico
authors: D
authors: Ciavarella
authors: Giuseppina
authors: G
authors: Campisi
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use; D002175:Candida / Q000187:drug effects; D005145:Face / Q000000981:diagnostic imaging / Q000473:pathology*; D019115:Fasciitis, Necrotizing / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D005402:Fistula / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use; D009336:Necrosis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D008795:Metronidazole