[Expressions of Th, DC, NK cells in cervical tissue and the relationship with immune functions].
OBJECTIVE
To investigate the different immune functions in normal cervix, CIN and cervical cancer tissue and the relationship between HPV infection and local cervical immune functions.


METHODS
The morphology, quantity, distribution and optical density of CD4+ Th cells, S-100 dendritic cells and CD57+ NK cells in normal cervical tissue, CIN cervical tissue and cervical cancer tissue were determined by immunohistochemistry and imaging analysis.


RESULTS
In the precancerous lesions, the numbers of the CD4+ Th cells, S-100+ DC and CD57+ NK cells increased with the disease progression in CIN (P < 0.05). But, after carcinogenesis, the immune cells decreased in local cervix tissue (P < 0.05).


CONCLUSIONS
The local tissue of human cervical precancerous lesions had more heightened immune functions as compared with the cancer tissue.
Ma
Cui
C
Beijing Gynecology and Obstetrics Hospital Affiliated to Capital Medical University, Beijing 100026, China.
Zhang
Wei-yuan
WY
Wang
Jian-dong
JD
D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000276:immunology* / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D008875:Middle Aged; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000276:immunology* / Q000378:metabolism / Q000473:pathology