title: [Preparation and properties of novel human-like collagen-silk fibroin scaffold for blood vessel].
abstract: In order to improve tensile property of vascular scaffold, we blended silk fibroin with novel human-like collagen with the mass ratio of 9:1, 7:3 and 5:5 (W/W), and then fabricated blood vessel tubular graft by freeze-drying process. We studied microstructure, mechanical properties, elements composites, degradability and biocompatibility of vascular scaffolds. These results showed that tubular scaffold with mass ratio 7:3 exhibited interconnected porous structure with pore size at (60 +/- 5) microm and porosity of 85%; achieved the desirable mechanical property (strain of 50% +/- 5% and stress of 332 +/- 16 kPa); had relatively slow degradation rate; could enhance cell adhesion and proliferation and had superior biocompatibility.
authors: Shaanxi Key Laboratory of Degradable Biomedical Materials, Northwest University, Xi'an 710069, China.
authors: Chenhui
authors: C
authors: Zhu
authors: Daidi
authors: D
authors: Fan
authors: Xiaoxuan
authors: X
authors: Ma
authors: Wenjiao
authors: W
authors: Xue
authors: Junfeng
authors: J
authors: Hui
authors: Lan
authors: L
authors: Chen
authors: Zhiguang
authors: Z
authors: Duan
authors: Pu
authors: P
authors: Ma
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D001696:Biomechanical Phenomena; D001808:Blood Vessels / Q000502:physiology*; D003094:Collagen / Q000737:chemistry*; D005349:Fibroins / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D016062:Porosity; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D003094:Collagen; D005349:Fibroins