CD9 gene variations are not associated with female infertility in humans.
OBJECTIVE
To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans.


METHODS
We sequenced the entire coding region of this gene in 86 Japanese women with unexplained infertility and further conducted a case-control study of six tagging single nucleotide polymorphisms (SNPs) in this gene using an additional 164 samples obtained from a fertile control group.


RESULTS
No disease-causing mutation in the CD9 gene was evident in these samples and no significant association between the tagging SNPs and the studied cohort was identified.


CONCLUSIONS
Our findings do not support the hypothesis that genetic alterations of the CD9 gene cause female infertility in humans.
Nishiyama
Sachie
S
Division of Molecular Genetics, Institute for Comprehensive Medical Science, Toyoake, Japan.
Kishi
Taro
T
Kato
Takema
T
Suzuki
Machiko
M
Nishizawa
Haruki
H
Pryor-Koishi
Kanako
K
Sawada
Tomio
T
Nishiyama
Yukio
Y
Iwata
Nakao
N
Udagawa
Yasuhiro
Y
Kurahashi
Hiroki
H
D000328:Adult; D015703:Antigens, CD / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007247:Infertility, Female / Q000235:genetics*; D007564:Japan; D008562:Membrane Glycoproteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D060245:Tetraspanin 29
D015703:Antigens, CD; C554869:CD9 protein, human; D008562:Membrane Glycoproteins; D060245:Tetraspanin 29; D004247:DNA