Viruses as vaccine vectors for infectious diseases and cancer.
Recent developments in the use of viruses as vaccine vectors have been facilitated by a better understanding of viral biology. Advances occur as we gain greater insight into the interrelationship of viruses and the immune system. Viral-vector vaccines remain the best means to induce cellular immunity and are now showing promise for the induction of strong humoral responses. The potential benefits for global health that are offered by this field reflect the scope and utility of viruses as vaccine vectors for human and veterinary applications, with targets ranging from certain types of cancer to a vast array of infectious diseases.
Draper
Simon J
SJ
The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK. simon.draper@ndm.ox.ac.uk
Heeney
Jonathan L
JL
D003140:Communicable Disease Control; D005822:Genetic Vectors; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D009369:Neoplasms / Q000517:prevention & control*; D014611:Vaccination / Q000379:methods*; D014612:Vaccines / Q000235:genetics / Q000276:immunology*; D014780:Viruses / Q000235:genetics / Q000276:immunology*
D014612:Vaccines