Transcriptional regulation of metastatic [Id]entity by KLF17.
A novel in vivo screening approach has identified KLF17 as a key metastasis suppressor gene that acts through regulation of Id1 transcription factor-dependent induction of the epithelial-to-mesenchymal transition.
Iwanicki
Marcin P
MP
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
Brugge
Joan S
JS
D018450:Disease Progression; D004848:Epithelium / Q000378:metabolism; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051798:Inhibitor of Differentiation Protein 1 / Q000378:metabolism; D008648:Mesoderm / Q000378:metabolism; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism*; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics*
C497453:ID1 protein, human; D051798:Inhibitor of Differentiation Protein 1; C510638:KLF17 protein, human; D014157:Transcription Factors