Neuroactive steroids: an update of their roles in central and peripheral nervous system.
After five editions, the congress on "Steroids and Nervous System" held in Torino, Italy, represents an important international event for researchers involved in this field aimed to recapitulate mechanisms, physiological and pharmacological effects of neuroactive steroids. The present review introduces manuscripts collected in this supplement issue which are based on new interesting findings such as the influence of sex steroids on cannabinoid-regulated biology, the role of steroids in pain, the importance of co-regulators in steroidal mechanisms and the understanding of new non classical mechanism, the emerging role of vitamin D as a neuroactive steroid and the pathogenetic mechanisms mediated by glucocorticoid receptors. Finally, we have integrated these aspects with an update on some of the several and important observations recently published on this hot topic.
Melcangi
Roberto Cosimo
RC
Dept. of Endocrinology, Pathophysiology, and Applied Biology-Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy. roberto.melcangi@unimi.it
Panzica
Giancarlo
G
D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D002493:Central Nervous System Diseases / Q000188:drug therapy; D002762:Cholecalciferol / Q000502:physiology; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000627:therapeutic use; D018377:Neurotransmitter Agents / Q000502:physiology*; D017933:Peripheral Nervous System / Q000502:physiology*; D012727:Sex Characteristics
D018696:Neuroprotective Agents; D018377:Neurotransmitter Agents; D002762:Cholecalciferol