title: [Multifunctional regulatory mutation in Bacillus subtilis flavinogenesis system].
abstract: Among Bacillus subtilis riboflavin-resistant mutants we identified one, which differed from other regulatory mutants by overproduction of riboflavin and simultaneous upregulation of the rib C gene encoding flavokinase/FAD-synthase. Genetic and biochemical analysis showed that the ribU1 mutation determines a trans-acting factor that simultaneously regulates activity of riboflavin and truB-ribC-rpsO operons. Regulatory activity of the ribU1 mutation comprises about 10% of Rfn element activity on interaction with flavins. The ribUl mutation can be presumably ascribed to a gene of the transcriptional regulators family.
authors: R A
authors: RA
authors: Kreneva
authors: D V
authors: DV
authors: Karelov
authors: N V
authors: NV
authors: Korol'kova
authors: A S
authors: AS
authors: Mironov
authors: D A
authors: DA
authors: Perumov
mesh_terms: D001412:Bacillus subtilis / Q000201:enzymology / Q000235:genetics*; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics; D009154:Mutation; D009713:Nucleotidyltransferases / Q000096:biosynthesis / Q000235:genetics*; D009876:Operon / Q000235:genetics; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000096:biosynthesis / Q000235:genetics*; D017319:Photosensitizing Agents / Q000494:pharmacology; D012256:Riboflavin / Q000096:biosynthesis / Q000235:genetics* / Q000494:pharmacology; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D017319:Photosensitizing Agents; D014157:Transcription Factors; C105392:RibC protein, bacteria; D017853:Phosphotransferases (Alcohol Group Acceptor); C022532:riboflavin kinase; D009713:Nucleotidyltransferases; D012256:Riboflavin