title: Live birth after polar body array comparative genomic hybridization prediction of embryo ploidy-the future of IVF?
abstract: OBJECTIVE
  To ascertain meiotic aneuploidy of the human egg using array comparative genomic hybridization to evaluate the 23-paired chromosome copy number of first polar body as an objective prognosticator of embryo viability for embryo transfer in the same cycle.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Independent-sector IVF program.
  
  
  METHODS
  A 41-year-old woman with a history of 13 failed cycles of IVF.
  
  
  METHODS
  Polar body biopsy of metaphase II eggs.
  
  
  METHODS
  Birth.
  
  
  RESULTS
  Two of the nine eggs were euploid, and the resulting embryos, although morphologically inferior to sibling embryos, were selected for transfer to the uterus, resulting in the birth of a normal healthy baby.
  
  
  CONCLUSIONS
  Selection of euploid eggs, as an objective parameter of subsequent embryo viability and with the opportunity to transfer embryos in the same cycle could maximise the opportunity for live birth after IVF even in cases with poor prognosis.
authors: CARE Fertility, John Webster House, 6 Lawrence Drive, Nottingham Business Park, Nottingham NG8 6PZ, United Kingdom. simon.fishel@carefertility.com
authors: Simon
authors: S
authors: Fishel
authors: Anthony
authors: A
authors: Gordon
authors: Colleen
authors: C
authors: Lynch
authors: Ken
authors: K
authors: Dowell
authors: George
authors: G
authors: Ndukwe
authors: Ehab
authors: E
authors: Kelada
authors: Simon
authors: S
authors: Thornton
authors: Lucy
authors: L
authors: Jenner
authors: Ellen
authors: E
authors: Cater
authors: Anthony
authors: A
authors: Brown
authors: Jose
authors: J
authors: Garcia-Bernardo
mesh_terms: D000328:Adult; D001706:Biopsy; D055028:Comparative Genomic Hybridization; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000639:trends*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D050498:Live Birth; D008297:Male; D011003:Ploidies; D011237:Predictive Value of Tests; D019836:Preimplantation Diagnosis / Q000639:trends*