Overcoming the drug resistance in breast cancer cells by rational design of efficient glutathione S-transferase inhibitors.
A new type of competitive human GST inhibitors has been developed via the bioisostere and structure activity profile strategies; we report their discovery, preparation, inhibitory activity, and synergetic effect in combination with chemotherapy drugs against breast cancer cells.
Li
Wen-Shan
WS
Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan. wenshan@chem.sinica.edu.tw
Lam
Wing See
WS
Liu
Kung-Cheng
KC
Wang
Chie-Hong
CH
Chang
Hui Chuan
HC
Jen
Ya Ching
YC
Hsu
Yu-Ting
YT
Shivatare
Sachin S
SS
Jao
Shu-Chuan
SC
D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics; D015195:Drug Design; D019008:Drug Resistance, Neoplasm / Q000187:drug effects* / Q000235:genetics; D005260:Female; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D013329:Structure-Activity Relationship
D005982:Glutathione Transferase