Total-and lipid-associated sialic acid in serum and thrombocytes in patients with chronic heart failure.
OBJECTIVE
To investigate and discuss the total-, lipid-associated, and thrombocyte-sialic acid levels in chronic heart failure (CHF) patients.


METHODS
Thirty-one chronic heart failure patients and 38 healthy controls were included in the study. Serum total sialic acid (TSA), lipid associated sialic acid (LASA), thrombocyte sialic acid (TrSA) were determined together with the traditional inflammation and prognostic markers.


RESULTS
Serum TSA levels were significantly higher in patient group (3.08 + or - 0.33 mmol/L) than control group (2.60 + or - 0.17 mmol/L). Serum LASA, homocysteine, high-sensitivity CRP, brain natriuretic peptide and erythrocyte sedimentation rate were also significantly higher in patient group. TrSA levels were not significant between the groups.


CONCLUSIONS
TSA and LASA levels increase in CHF, independent from coronary artery disease. TrSA levels were not found to be a prognostic or valuable marker for CHF patients. Acute phase response and lipid associated portions of SA are thought to be responsible for SA rise in CHF.
Topçuoğlu
Canan
C
Ankara Training and Research Hospital Department of Clinical Biochemistry, Ankara, Turkey.
Yilmaz
Fatma Meriç
FM
Sahin
Deniz
D
Aydoğdu
Sinan
S
Yilmaz
Gülsen
G
Saydam
Gülsevim
G
Yücel
Doğan
D
D001792:Blood Platelets / Q000378:metabolism*; D003710:Demography; D005260:Female; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid / Q000097:blood*
D008055:Lipids; C054080:lipid-associated sialic acid; D019158:N-Acetylneuraminic Acid