title: Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis.
abstract: OBJECTIVE
  To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1) gene in patients with spontaneous bacterial peritonitis (SBP).
  
  
  METHODS
  MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.
  
  
  RESULTS
  The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However, in the subgroup of patients with alcoholic cirrhosis (n = 80), carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%, P = 0.021).
  
  
  CONCLUSIONS
  In patients with alcoholic liver cirrhosis, the -2518 MCP-1 genotype AA is a risk factor for the development of SBP.
authors: Department of Internal Medicine I, University Medical Center Regensburg, Regensburg, Germany.
authors: Erwin
authors: E
authors: Gäbele
authors: Marcus
authors: M
authors: Mühlbauer
authors: Hartwig
authors: H
authors: Paulo
authors: Monika
authors: M
authors: Johann
authors: Christin
authors: C
authors: Meltzer
authors: Franz
authors: F
authors: Leidl
authors: Norbert
authors: N
authors: Wodarz
authors: Reiner
authors: R
authors: Wiest
authors: Jürgen
authors: J
authors: Schölmerich
authors: Claus
authors: C
authors: Hellerbrand
mesh_terms: D000328:Adult; D000483:Alleles; D001201:Ascites / Q000235:genetics / Q000382:microbiology; D001424:Bacterial Infections / Q000235:genetics* / Q000382:microbiology; D018932:Chemokine CCL2 / Q000235:genetics*; D005260:Female; D005355:Fibrosis / Q000175:diagnosis / Q000235:genetics; D005838:Genotype; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000235:genetics* / Q000382:microbiology; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D018932:Chemokine CCL2