[Molecular mechanisms of stress adaptation: immediate early genes].
Immediate early gene (IEG) expression is the important part of adaptive reactions caused by short-term high-intensity physical activities. IEG leads to activation of transcription, protein neo-synthesis and form-specific stress response. We were looking for human body physical exercise adaptation leukocytes IEG expression markers. Gene expression profiles were measured using microarray technology and validated by real time PCR. In this study, we describe several cell stress adaptation regulators groups: stress response, splicing and cell signaling.
Grigor'ev
A I
AI
Tonevitskiĭ
A G
AG
D000222:Adaptation, Physiological / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D020869:Gene Expression Profiling / Q000379:methods; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D014176:Protein Biosynthesis / Q000502:physiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D013312:Stress, Physiological / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology*
D015415:Biomarkers