title: Development of liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry for analysis of halogenated flame retardants in wastewater.
abstract: Until recently, atmospheric pressure photoionization (APPI) has typically been used for the determination of non-polar halogenated flame retardants (HFRs) by liquid chromatography (LC) tandem mass spectrometry. In this study, we demonstrated the feasibility of utilizing liquid chromatography atmospheric pressure chemical ionization (APCI) tandem mass spectrometry (LC-APCI-MS/MS) for analysis of 38 HFRs. This developed method offered three advantages: simplicity, rapidity, and high sensitivity. Compared with APPI, APCI does not require a UV lamp and a dopant reagent to assist atmospheric pressure ionization. All the isomers and the isobaric compounds were well resolved within 14-min LC separation time. Excellent instrument detection limits (6.1 pg on average with 2.0 muL injection) were observed. The APCI mechanism was also investigated. The method developed has been applied to the screening of wastewater samples for screening purpose, with concentrations determined by LC-APCI-MS/MS agreeing with data obtained via gas chromatography high resolution mass spectrometry.
authors: Department of Chemistry, Brock University, St. Catharines, ON, L2S 3A1, Canada. simon.zhou@ontario.ca
authors: Simon Ningsun
authors: SN
authors: Zhou
authors: Eric J
authors: EJ
authors: Reiner
authors: Chris
authors: C
authors: Marvin
authors: Paul
authors: P
authors: Helm
authors: Nicole
authors: N
authors: Riddell
authors: Frank
authors: F
authors: Dorman
authors: Michelle
authors: M
authors: Misselwitz
authors: Li
authors: L
authors: Shen
authors: Patrick
authors: P
authors: Crozier
authors: Karen
authors: K
authors: Macpherson
authors: Ian D
authors: ID
authors: Brindle