title: The effect of a single dose of bupivacaine on donor site pain after anterior iliac crest bone harvesting.
abstract: Transplants from the anterior iliac crest are used for most reconstructive procedures in cranio-maxillofacial surgery. The advantages are easy accessibility, the ability to work in two teams and the amount of corticocancellous bone available; disadvantages are postoperative pain and gait disturbances. To reduce donor-site pain, the effect of a single dose of bupivacaine (10 cc of 2.5mg/cc with 1:80.000 epinephrine) was studied. 200 consecutive patients, who underwent anterior iliac crest bone harvesting for reconstructive procedures, were randomly divided into those receiving bupivacaine and those not. They completed a standardized questionnaire. Patients scored the intensity of the pain and difficulties walking at different times with a visual analogue scale. They recorded analgesics used. 98 questionnaires were eligible for analysis. No differences between the bupivacaine and the control group were detected for postoperative pain and gait disturbance. There is no support for administration of a single dose of bupivacaine to reduce pain in the first postoperative days. The surface area of the removed bone had a significant influence on pain and walking; pain is related to the local osseous damage or periosteal stripping rather than to the length of incision or the operation time.
authors: Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors: R
authors: R
authors: Barkhuysen
authors: G J
authors: GJ
authors: Meijer
authors: A
authors: A
authors: Soehardi
authors: M A W
authors: MA
authors: Merkx
authors: W A
authors: WA
authors: Borstlap
authors: S J
authors: SJ
authors: Bergé
authors: E M
authors: EM
authors: Bronkhorst
authors: T J M
authors: TJ
authors: Hoppenreijs
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000540:Alveolar Ridge Augmentation / Q000379:methods; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000779:Anesthetics, Local / Q000008:administration & dosage*; D016063:Blood Loss, Surgical; D016025:Bone Transplantation / Q000379:methods*; D002045:Bupivacaine / Q000008:administration & dosage*; D004837:Epinephrine / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use; D007085:Ilium / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010027:Osteotomy / Q000379:methods; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control; D011446:Prospective Studies; D019651:Plastic Surgery Procedures / Q000379:methods; D013997:Time Factors; D020858:Tissue and Organ Harvesting / Q000379:methods*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage; D016138:Walking / Q000502:physiology; D055815:Young Adult
chemical_list: D018712:Analgesics, Non-Narcotic; D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D000082:Acetaminophen; D007052:Ibuprofen; D002045:Bupivacaine; D004837:Epinephrine