title: Antiangiogenic therapies in breast cancer.
abstract: Angiogenesis is a complex, multistep process that is involved in the progression and prognosis of several types of cancer. In particular, it has been demonstrated that angiogenesis plays a central role in the progression of breast cancer. This review evaluates results from clinical trials in which the efficacy of conventional chemotherapeutic agents was compared with that of novel antiangiogenic compounds for the treatment of breast cancer, and provides a summary of trials that were ongoing at the time of publication in the neoadjuvant and adjuvant settings.
authors: San Filippo Neri Hospital, Division of Medical Oncology, Unit of Oncology, Via Martinotti 20, 00135, Rome, Italy.
authors: Roberta
authors: R
authors: Sarmiento
authors: Mario Rosario
authors: MR
authors: D'Andrea
authors: Francesca
authors: F
authors: Cacciamani
authors: Francesca
authors: F
authors: Salerno
authors: Giampietro
authors: G
authors: Gasparini
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant / Q000379:methods; D002986:Clinical Trials as Topic; D018450:Disease Progression; D005260:Female; D006801:Humans; D020360:Neoadjuvant Therapy / Q000379:methods; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D011379:Prognosis
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents