Gamma band oscillations under influence of bromazepam during a sensorimotor integration task: an EEG coherence study.
The goal of the present study was to explore the dynamics of the gamma band using the coherence of the quantitative electroencephalography (qEEG) in a sensorimotor integration task and the influence of the neuromodulator bromazepam on the band behavior. Our hypothesis is that the needs of the typewriting task will demand the coupling of different brain areas, and that the gamma band will promote the binding of information. It is also expected that the neuromodulator will modify this coupling. The sample was composed of 39 healthy subjects. We used a randomized double-blind design and divided subjects into three groups: placebo (n=13), bromazepam 3mg (n=13) and bromazepam 6 mg (n=13). The two-way ANOVA analysis demonstrated a main effect for the factors condition (i.e., C4-CZ electrode pair) and moment (i.e., C3-CZ, C3-C4 and C4-CZ pairs of electrodes). We propose that the gamma band plays an important role in the binding among several brain areas in complex motor tasks and that each hemisphere is influenced in a different manner by the neuromodulator.
Minc
Daniel
D
Brain Mapping and Sensory Motor Integration, Institute of Psychiatry of Federal University of Rio de Janeiro (IPUB/UFRJ), Rio de Janeiro, RJ, Brazil.
Machado
Sergio
S
Bastos
Victor Hugo
VH
Machado
Dionis
D
Cunha
Marlo
M
Cagy
Mauricio
M
Budde
Henning
H
Basile
Luis
L
Piedade
Roberto
R
Ribeiro
Pedro
P
D000328:Adult; D001960:Bromazepam / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography; D005260:Female; D018757:GABA Modulators / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D009048:Motor Skills / Q000187:drug effects*; D010507:Periodicity; D013003:Somatosensory Cortex / Q000187:drug effects* / Q000502:physiology; D055815:Young Adult
D018757:GABA Modulators; D001960:Bromazepam