Hypoglycemic action of chicken meat extract in type-2 diabetic KKAy mice and GK rats.
This study researched the effects of chicken meat extract on blood glucose and insulin level, membrane glucose transporter-4 (GLUT4), and tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) in type 2 diabetic KKAy mice and GK rats. Eight-week-old KKAy mice and GK rats and euglycemic control animals, C57BL/6J mice and Wistar rats, were orally administered a liquid commercial chicken meat extract, BRAND'S Essence of Chicken (BEC), for up to 8 weeks. BEC (1.5 ml/kg) had no effect on blood insulin levels, but significantly lessened the hyperglycemia in the diabetic animals. In the BEC-treated diabetic animals, insulin induced a significant increase in plasma membrane GLUT4 and cytosolic tyrosine-phosphorylated IRS-1, indicating that it attenuates insulin resistance. The present findings are the first demonstration of the hypoglycemic action of a dietary protein, and they lend credence to the reported benefits of using chicken meat as a source of protein in the dietary management of diabetic individuals.
Sim
Meng-Kwoon
MK
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. phcsimmk@nus.edu.sg
Wong
Yong-Chiat
YC
Xu
Xiao-Guang
XG
Sim
Sai-Zhen
SZ
Tsi
Daniel
D
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002645:Chickens; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000178:diet therapy* / Q000378:metabolism; D004044:Dietary Proteins / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006943:Hyperglycemia / Q000150:complications / Q000178:diet therapy*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008460:Meat; D051379:Mice; D010766:Phosphorylation / Q000187:drug effects; D051381:Rats; D014443:Tyrosine / Q000378:metabolism
D001786:Blood Glucose; D004044:Dietary Proteins; D007328:Insulin; D014443:Tyrosine