Connective tissue growth factor-(CTGF, CCN2)--a marker, mediator and therapeutic target for renal fibrosis.
Connective tissue growth factor (CTGF, CCN2) is a key mediator of tissue fibrosis. CCN2 plays an important role in the development of glomerular and tubulointerstitial fibrosis in progressive kidney diseases. In this review, we discuss the biology of CCN2 with a focus on the regulation of CCN2 gene, cellular mechanisms of profibrotic CCN2 effects and the current in vivo and in vitro evidence for the role of CCN2 in the development of renal fibrosis. We also discuss the therapeutic potential of targeting CCN2 for the treatment of renal fibrosis.
Phanish
Mysore K
MK
SW Thames Institute for Renal Research, St. Helier Hospital, London, UK. mysore.phanish@esth.nhs.uk
Winn
S K
SK
Dockrell
M E C
ME
D001483:Base Sequence; D015415:Biomarkers / Q000378:metabolism; D055513:Connective Tissue Growth Factor / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D005355:Fibrosis; D005786:Gene Expression Regulation; D006801:Humans; D007668:Kidney / Q000196:embryology / Q000473:pathology*; D007674:Kidney Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology
D015415:Biomarkers; D055513:Connective Tissue Growth Factor