[Effect of vitamin K on bone material properties].
Collagen cross-links are determinants of bone quality. Because vitamin K is thought to ameliorate bone quality, we summarized the literature regarding the effect of vitamin K such as menatetorenone (MK-4) on bone matrix property in the review. MK-4 seems to stimulate the osteoblastic activity. This results in the increase in collagen accumulation and lysyl oxidase controlled enzymatic cross-links in bone. Furthermore, vitamin K stimulates the secretion of collagen binding protein regulating proper fibrillogenesis such as leucine-rich repeat protein (tsukushi). This kinds of non-collagenous proteins induced by the treatment of vitamin K may also affect proper collagen cross-link formation and show the favorable effect on bone material quality.
Saito
Mitsuru
M
Department of Orthopaedic Surgery, Jikei University School of Medicine, Japan.
D000818:Animals; D001857:Bone Matrix / Q000201:enzymology / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism; D006801:Humans; D000090263:Leucine-Rich Repeat Proteins; D010006:Osteoblasts / Q000502:physiology; D010024:Osteoporosis / Q000188:drug therapy / Q000378:metabolism; D008249:Protein-Lysine 6-Oxidase / Q000502:physiology; D011506:Proteins / Q000378:metabolism; D013268:Stimulation, Chemical; D024482:Vitamin K 2 / Q000494:pharmacology* / Q000627:therapeutic use
D000090263:Leucine-Rich Repeat Proteins; D011506:Proteins; D024482:Vitamin K 2; D003094:Collagen; D008249:Protein-Lysine 6-Oxidase