Intraspecies transmission of L-type-like Bovine Spongiform Encephalopathy detected in Japan.
It has been assumed that the agent causing BSE in cattle is a uniform strain (classical BSE); however, different neuropathological and molecular phenotypes of BSE (atypical BSE) have been recently reported. We demonstrated the successful transmission of L-type-like atypical BSE detected in Japan (BSE/JP24 isolate) to cattle. Based on the incubation period, neuropathological hallmarks, and molecular properties of the abnormal host prion protein, the characteristics of BSE/JP24 prion were apparently distinguishable from the classical BSE prion and closely resemble those of bovine amyloidotic spongiform encephalopathy prion detected in Italy.
Fukuda
Shigeo
S
Molecular Biotechnology Laboratory, Hokkaido Animal Research Center, Shintoku, Hokkaido, Japan.
Iwamaru
Yoshifumi
Y
Imamura
Morikazu
M
Masujin
Kentarou
K
Shimizu
Yoshihisa
Y
Matsuura
Yuichi
Y
Shu
Yujing
Y
Kurachi
Megumi
M
Kasai
Kazuo
K
Murayama
Yuichi
Y
Onoe
Sadao
S
Hagiwara
Ken'ichi
K
Sata
Tetsutaro
T
Mohri
Shirou
S
Yokoyama
Takashi
T
Okada
Hiroyuki
H
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics / Q000473:pathology / Q000635:transmission*; D016643:Encephalopathy, Bovine Spongiform / Q000235:genetics / Q000473:pathology / Q000635:transmission*; D055256:Infectious Disease Incubation Period; D007564:Japan; D008526:Medulla Oblongata / Q000473:pathology; D051379:Mice; D018621:PrPC Proteins / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D017096:Prion Diseases / Q000235:genetics / Q000635:transmission; D011328:Prions / Q000145:classification / Q000472:pathogenicity; D013045:Species Specificity
D018621:PrPC Proteins; D011328:Prions