title: In-vitro evaluation of the PediaSat continuous central venous oxygenation monitoring system.
abstract: OBJECTIVE
  In-vitro performance of the PediaSat system for continuous monitoring of central venous oxygen saturation by spectrophotometry has been evaluated.
  
  
  METHODS
  PediaSat continuous fibre-optic oximetry catheters were inserted in a black testing chamber, connected with an extracorporeal circuit and filled with human whole blood. Oxygen inflow into the cardiopulmonary bypass system was varied, and the testing chamber was perfused with blood flow of 1000 ml min(-1). Oxygen saturation values measured by PediaSat (S PediaSat O2) were compared with cooximetry (S CO-OX O2) values from simultaneously taken blood samples by Bland-Altman and simple regression analyses.
  
  
  RESULTS
  Fifty data pairs were obtained. S PediaSat O2 and S CO-OX O2 values ranged between 28-98 and 24.9-99.5%, respectively. Correlation between S PediSat O2 and S CO-OX O2 was high with an r2 value equal to 0.96 (P < 0.0001). Overall, S PediaSat O2 only slightly overestimated S CO-OX O2 (mean bias +2.9%), and limits of agreement (+/-2 SD of bias) were acceptable (-6.8/+12.6%). Sensitivity and specificity of the first differences of S PediaSat O2 and S CO-OX O2 were 1.0 and 0.92, respectively. Subgroup analysis of S CO-OX O2 values below 70% resulted in an overestimation by S PediaSat O2, with a mean bias of +5.2% and limits of agreement of -4.7 and +15.1%.
  
  
  CONCLUSIONS
  The current version of the PediaSat system does not reliably reflect S CO-OX O2 values below 70%, but it seems to be a useful tool providing an accurate trend of continuous central venous oxygen saturation.
authors: Institute of Anaesthesiology, University Hospital Zurich, Zurich, Switzerland. werner.baulig@usz.ch
authors: Werner
authors: W
authors: Baulig
authors: Nelly
authors: N
authors: Spielmann
authors: Hassan
authors: H
authors: Zaiter
authors: Tomislav
authors: T
authors: Lijovic
authors: Dominique
authors: D
authors: Bettex
authors: Christoph
authors: C
authors: Bürki
authors: Markus
authors: M
authors: Weiss
mesh_terms: D001784:Blood Gas Analysis / Q000295:instrumentation / Q000379:methods / Q000592:standards; D002405:Catheterization, Central Venous / Q000295:instrumentation* / Q000379:methods / Q000592:standards*; D005336:Fiber Optic Technology / Q000295:instrumentation / Q000379:methods / Q000592:standards; D006801:Humans; D016343:Monitoring, Intraoperative / Q000295:instrumentation* / Q000379:methods / Q000592:standards*; D010092:Oximetry / Q000295:instrumentation / Q000379:methods / Q000592:standards; D010101:Oxygen Consumption / Q000502:physiology; D013055:Spectrophotometry, Infrared / Q000295:instrumentation / Q000379:methods / Q000592:standards