title: Pityriasis rubra pilaris presenting with an abnormal autoimmune profile: two case reports.
abstract: BACKGROUND
  Pityriasis rubra pilaris is an uncommon inflammatory and hyperproliferative dermatosis of juvenile or adult onset. The etiology of the disease is still unknown.
  
  
  METHODS
  We present the cases of two Caucasian men aged 53 and 48 who presented with pityriasis rubra pillaris type 1; both patients also exhibited an abnormal immunological profile.
  
  
  CONCLUSIONS
  Pityriasis rubra pillaris is currently classified as a keratinization disorder. The abnormal immunological profile reported in our patients along with the comorbidity of pityriasis rubra pilaris with autoimmune disorders reported in the literature poses the question of a possible pathogenetic role for the immune response in this disorder.
authors: University of Athens Medical School, Department of Dermatology, Athens, Greece.
authors: Stamatis
authors: S
authors: Gregoriou
authors: Zoe
authors: Z
authors: Chiolou
authors: Christina
authors: C
authors: Stefanaki
authors: Niki
authors: N
authors: Zakopoulou
authors: Dimitrios
authors: D
authors: Rigopoulos
authors: George
authors: G
authors: Kontochristopoulos