Properties and clinical development of a novel coating technology: the poly[bis(trifluoroethoxy)phosphazene].
Ultrapure poly[bis(trifluoroethoxy)phosphazene] is a novel biocompatible, anti-inflammatory, antithrombogenic polymer which has the potential to cover stent devices without elution of a cell cycle inhibiting drug. The properties of polyphosphazene are likely to extend its use to a broad array of promising applications. This article reviews the features of the polymer and some recent patents related to use of poly[bis(trifluoroethoxy)phosphazene] in coating, its relevance as compared to other polymers, current evidence on pre-clinical and clinical performance, and future perspectives.
Capodanno
Davide
D
Cardiovascular Department, Ferrarotto Hospital, University of Catania, Catania, Italy. dcapodanno@gmail.com
Tamburino
Corrado
C
D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D020099:Coated Materials, Biocompatible; D006083:Graft Occlusion, Vascular; D006801:Humans; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D015607:Stents
D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D009943:Organophosphorus Compounds; D011108:Polymers; C081660:poly(bis(trifluoroethoxy)phosphazene)