title: [The correlation of human serum Lp-PLA2 and hs-CRP and stability of coronary atherosclerotic plaques].
abstract: OBJECTIVE
  To explore the relationship of serum lipoprotein-associated phospholipase A2 and high sensitive C-reactive protein in vulnerable coronary atherosclerotic plaques.
  
  
  METHODS
  Patients undergoing coronary angiography (CAG) were examined for CAD with intravascular ultrasound (IVUS). According to the findings of CAG and IVUS, all the patients were divided into three groups: a control group without plaque, stable plaque group and vulnerable plaque group. The total serum Lp-PLA2 and hs-CRP were measured before angiography and they were valued with T test and Pearson's correlation analysis.
  
  
  RESULTS
  (1) Lp-PLA2 level in stable plaque group and vulnerable plaque group was higher than that in control group (P < 0.05). (2) Lp-PLA2 level in the vulnerable plaque group was higher than that in stable plaque group (P < 0.05). (3) hs-CRP level in the vulnerable plaque group is higher than that in the stable plaque group and control group (P < 0.05) and there was significant difference between them. (4) To discriminate vulnerable plaque, the specificity of serum Lp-PLA2 was stronger than that of hs-CRP.
  
  
  CONCLUSIONS
  Serum Lp-PLA2 level has higher sensitivity in predicting the vulnerability of the coronary atherosclerotic plaque than hs-CRP. In combination with hs-CRP, we can use Lp-PLA2 as a new biomarker to predict the presence of vulnerable plaque.
authors: Department of Cardiology, Second Hospital of Shandong University, Jinan 250033, China.
authors: Dong-Ling
authors: DL
authors: Xu
authors: Jun-Ni
authors: JN
authors: Liu
authors: Yi-Meng
authors: YM
authors: Du
authors: Gui-Hua
authors: GH
authors: Yao
authors: Wei-Dong
authors: WD
authors: Jiang
authors: Xin
authors: X
authors: Wang
authors: Zhao-Qiang
authors: ZQ
authors: Dong
authors: Lin
authors: L
authors: Hao
authors: Guang-Yun
authors: GY
authors: Wang
authors: Shu-Jian
authors: SJ
authors: Sui
authors: Ji-Fu
authors: JF
authors: Li
authors: Qing-Hua
authors: QH
authors: Lu
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000097:blood* / Q000473:pathology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D018084:Ultrasonography, Interventional
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase