title: Management of newly diagnosed symptomatic multiple myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus guidelines.
abstract: Multiple myeloma is a malignant plasma cell neoplasm that affects more than 20,000 people each year and is the second most common hematologic malignancy. It is part of a spectrum of monoclonal plasma cell disorders, many of which do not require active therapy. During the past decade, considerable progress has been made in our understanding of the disease process and factors that influence outcome, along with development of new drugs that are highly effective in controlling the disease and prolonging survival without compromising quality of life. Identification of well-defined and reproducible prognostic factors and introduction of new therapies with unique modes of action and impact on disease outcome have for the first time opened up the opportunity to develop risk-adapted strategies for managing this disease. Although these risk-adapted strategies have not been prospectively validated, enough evidence can be gathered from existing randomized trials, subgroup analyses, and retrospective studies to develop a working framework. This set of recommendations represents such an effort-the development of a set of consensus guidelines by a group of experts to manage patients with newly diagnosed disease based on an interpretation of the best available evidence.
authors: Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. kumar.shaji@mayo.edu
authors: Shaji K
authors: SK
authors: Kumar
authors: Joseph R
authors: JR
authors: Mikhael
authors: Francis K
authors: FK
authors: Buadi
authors: David
authors: D
authors: Dingli
authors: Angela
authors: A
authors: Dispenzieri
authors: Rafael
authors: R
authors: Fonseca
authors: Morie A
authors: MA
authors: Gertz
authors: Philip R
authors: PR
authors: Greipp
authors: Suzanne R
authors: SR
authors: Hayman
authors: Robert A
authors: RA
authors: Kyle
authors: Martha Q
authors: MQ
authors: Lacy
authors: John A
authors: JA
authors: Lust
authors: Craig B
authors: CB
authors: Reeder
authors: Vivek
authors: V
authors: Roy
authors: Stephen J
authors: SJ
authors: Russell
authors: Kristen E Detweiler
authors: KE
authors: Short
authors: A Keith
authors: AK
authors: Stewart
authors: Thomas E
authors: TE
authors: Witzig
authors: Steven R
authors: SR
authors: Zeldenrust
authors: Robert J
authors: RJ
authors: Dalton
authors: S Vincent
authors: SV
authors: Rajkumar
authors: P Leif
authors: PL
authors: Bergsagel
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D014408:Biomarkers, Tumor / Q000235:genetics; D006801:Humans; D009101:Multiple Myeloma / Q000473:pathology / Q000628:therapy*; D017410:Practice Guidelines as Topic; D018570:Risk Assessment; D033581:Stem Cell Transplantation
chemical_list: D014408:Biomarkers, Tumor