Synthesis and photoactivated insecticidal activity of tetraethynylsilanes.
A series of tetraethynylsilanes (TETS) have been synthesized by reaction of silicon tetrachloride (SiCl(4)) with Ar-C triple bond CLi, which was prepared in situ by treatment of Ar-C triple bond CH with n-BuLi. For these TETS thus prepared, their photoactivated insecticidal activities against the 4th-instar larvae of Aedes albopictus (Skuse) were evaluated to enrich the structure-activity relationship. In particular, compound 8 exhibited excellent photoactivated insecticidal activity, the LC(50) value was 0.1346 mg L(-1) under UV light treatment and the irradiation-generated enhancement in the activity was more than 69.58-fold, thus could be exploitable as ideal analog candidates in the search for new photoactivated insecticide leads.
Shao
Guang
G
School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, PR China. shaog@mail.sysu.edu.cn
Jiang
Ding-Xin
DX
Xu
Han-Hong
HH
Zeng
Wei
W
Yu
Hui-Juan
HJ
Tian
Yong-Qing
YQ
D000330:Aedes / Q000187:drug effects / Q000528:radiation effects; D000818:Animals; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D007814:Larva / Q000187:drug effects / Q000528:radiation effects; D008027:Light; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D012821:Silanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D014466:Ultraviolet Rays
D007306:Insecticides; D017319:Photosensitizing Agents; D012821:Silanes; D013876:Thiophenes