Polylactide stereocomplex-based electrospun materials possessing surface with antibacterial and hemostatic properties.
Novel fibrous materials of stereocomplex between high-molecular-weight poly(d- or l-)lactide (HMPDLA or HMPLLA) and diblock copolymers consisting of poly(l- or d-)lactide and poly(N,N-dimethylamino-2-ethyl methacrylate) blocks, respectively (PLLA-block-PDMAEMA or PDLA-block-PDMAEMA), were prepared by solution electrospinning. Fibers with mean diameters ranging from 1400 to 1700 nm were obtained. The stereocomplex formation was evidenced by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analyses. Annealing at 100 degrees C for 8 h resulted in the appearance of crystalline peaks at 2theta values of 12, 21, and 24 degrees for PLA stereocomplex. X-ray photoelectron spectroscopy (XPS) analyses revealed the gradient composition of the fibers with a surface enriched in tertiary amino groups from PDMAEMA blocks. The availability of tertiary amino groups imparts hemostatic and antibacterial properties to the stereocomplex fibrous materials, as indicated by the performed tests on blood cells and on pathogenic microorganisms.
Spasova
Mariya
M
Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev str., bl. 103A, 1113 Sofia, Bulgaria.
Manolova
Nevena
N
Paneva
Dilyana
D
Mincheva
Rosica
R
Dubois
Philippe
P
Rashkov
Iliya
I
Maximova
Vera
V
Danchev
Dobri
D
D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D002448:Cell Adhesion / Q000187:drug effects*; D055664:Electrochemical Techniques; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008689:Methacrylates / Q000737:chemistry*; D056951:Photoelectron Spectroscopy; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism; D013237:Stereoisomerism; D013499:Surface Properties; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D008689:Methacrylates; D011091:Polyesters; D011108:Polymers; C542831:poly(lactide)-b-poly(N,N-dimethylamino-2-ethyl methacrylate); C033616:poly(lactide)