title: Nebivolol improves renal function in patients who underwent angioplasty due to renal artery stenosis: a pilot study.
abstract: Renal artery stenosis (RAS) is a progressive disease and may lead to chronic kidney disease by deterioration of renal functions. Endothelial dysfunction is an important causative factor for kidney damage after RAS revascularization. Nebivolol, a new generation beta blocker induces endothelium-related arterial relaxation by nitric oxide (NO) and may improve endothelial dysfunction. This pilot study tested the effect of nebivolol on the glomerular filtration rate (GFR) in a series of 33 patients with severe RAS (>70%) who underwent revascularization. After revascularization, nebivolol was added to antihypertensive treatment in 17 randomly selected patients while 16 patients (control group) continued their standard treatment. Estimated glomerular filtration rate (eGFR), proteinuria as well as nitrite and nitrate levels were measured at baseline and 6 months after the revascularization procedure. Six months after revascularization, eGFR increased from 44.8 to 50.6 ml/min in the nebivolol group. In contrast, eGFR did not change in the control group. Nitrite/nitrate levels decreased to a significant extent both in the nebivolol and in the control group. Proteinuria decreased more in the nebivolol group compared to the control group. These pilot data support a full-fledged clinical trial, testing whether nebivolol may be beneficial in the post-revascularization phase in patients with RAS.
authors: Department of Nephrology, Ankara Educational and Research Hospital, Ankara, Turkey.
authors: Murat
authors: M
authors: Duranay
authors: Mehmet
authors: M
authors: Kanbay
authors: Hatice
authors: H
authors: Akay
authors: Selman
authors: S
authors: Unverdi
authors: Hatice
authors: H
authors: Sürer
authors: Mustafa
authors: M
authors: Altay
authors: Ismail
authors: I
authors: Kirbaş
authors: Adrian
authors: A
authors: Covic
authors: Carmine
authors: C
authors: Zoccali
mesh_terms: D000368:Aged; D017130:Angioplasty / Q000009:adverse effects*; D001578:Benzopyrans / Q000008:administration & dosage*; D004983:Ethanolamines / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000068577:Nebivolol; D010865:Pilot Projects; D012078:Renal Artery Obstruction / Q000150:complications* / Q000601:surgery*; D051437:Renal Insufficiency / Q000209:etiology* / Q000517:prevention & control*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D001578:Benzopyrans; D004983:Ethanolamines; D014665:Vasodilator Agents; D000068577:Nebivolol