title: Adenosine induces G2/M cell-cycle arrest by inhibiting cell mitosis progression.
abstract: Cellular adenosine accumulates under stress conditions. Few papers on adenosine are concerned with its function in the cell cycle. The cell cycle is the essential mechanism by which all living things reproduce and the target machinery when cells encounter stresses, so it is necessary to examine the relationship between adenosine and the cell cycle. In the present study, adenosine was found to induce G-2/M cell-cycle arrest. Furthermore, adenosine was found to modulate the expression of some important proteins in the cell cycle, such as cyclin B and p21, and to inhibit the transition of metaphase to anaphase in mitosis.
authors: Jiangsu Center of Hepatobiliary Diseases, State Key Laboratory of Pharmaceutical Biotechnology, Affiliated Gulou Hospital, Nanjing University, Nanjing 210093, People's Republic of China.
authors: Kun-Zhi
authors: KZ
authors: Jia
authors: Bo
authors: B
authors: Tang
authors: Lu
authors: L
authors: Yu
authors: Wei
authors: W
authors: Cheng
authors: Rong
authors: R
authors: Zhang
authors: Jian-Fa
authors: JF
authors: Zhang
authors: Zi-Chun
authors: ZC
authors: Hua
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D000705:Anaphase; D002455:Cell Division; D002460:Cell Line; D019926:Cyclin B / Q000378:metabolism; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism; D005434:Flow Cytometry; D016195:G2 Phase; D006801:Humans; D008677:Metaphase; D008856:Microscopy, Fluorescence; D008938:Mitosis
chemical_list: D019926:Cyclin B; D050759:Cyclin-Dependent Kinase Inhibitor p21; D000241:Adenosine