[The study of killer cell immunoglobulin-like receptor 3DL2 gene polymorphisms and pre-eclampsia].
OBJECTIVE
To analyze a presumed association of gene polymorphism of killer cell immunoglobulin-like receptor three domains, long cytoplasmic tail, 2(KIR3DL2) gene with pre-eclampsia.


METHODS
The KIR3DL2 gene A52G in exon 3 and C32T in exon 9 polymorphism were determined by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) in 95 pre-eclampsia and 91 normal pregnant women.


RESULTS
There was significant difference between two group in exon 3 in terms of genotypes and allele (P < 0.05). There was a significant difference between two groups regarding the frequencies of exon 9 CC, CT and TT genotypes (P < 0.05). But no significant difference was found between mild pre-eclampsia and severe pre-eclampsia groups in terms of the two SNP loci (P > 0.05).


CONCLUSIONS
The A52G polymorphism in exon 3 and the frequencies of C32T in exon 9 of KIR3DL2 gene polymorphism are associated with the pathogenesis of pre-eclampsia, But it has no correlation with the severity of preeclampsia.
Wang
Xiao-lan
XL
Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Zhang
Wei-yuan
WY
Wang
Qi
Q
Sun
Cheng-juan
CJ
D000483:Alleles; D005091:Exons; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D054347:Receptors, KIR3DL2 / Q000235:genetics*
D054347:Receptors, KIR3DL2