title: A partial nontandem duplication of the MLL gene in four patients with acute myeloid leukemia.
abstract: Unusual MLL gene rearrangements were found in bone marrow cells of four patients with acute myeloid leukemia. A combination of conventional and molecular cytogenetic methods were used to describe translocations t(9;12;11)(p22;p13;q23), t(11;19)(q23;p13.3), and t(10;11)(p12;23) and inverted insertion ins(10;11)(p12;q23.3q23.1). Partial nontandem duplication of the MLL gene was identified by reverse transcriptase-polymerase chain reaction in all cases. The duplication, which included MLL exons 2 through 8-9, was interrupted by a cryptic insertion of one or two exons from the respective MLL partner gene: MLLT10, MLLT3, or MLLT1.
authors: Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic. iveta.sarova@uhkt.cz
authors: Iveta
authors: I
authors: Sárová
authors: Jana
authors: J
authors: Brezinová
authors: Zuzana
authors: Z
authors: Zemanová
authors: Libuse
authors: L
authors: Lizcová
authors: Adéla
authors: A
authors: Berková
authors: Silvia
authors: S
authors: Izáková
authors: Eva
authors: E
authors: Malinová
authors: Ota
authors: O
authors: Fuchs
authors: Arnost
authors: A
authors: Kostecka
authors: Dana
authors: D
authors: Provazníková
authors: Jitka
authors: J
authors: Filkuková
authors: Jacqueline
authors: J
authors: Maaloufová
authors: Jan
authors: J
authors: Starý
authors: Kyra
authors: K
authors: Michalová
mesh_terms: D000328:Adult; D001483:Base Sequence; D017931:DNA Primers; D005260:Female; D020440:Gene Duplication; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014178:Translocation, Genetic
chemical_list: D017931:DNA Primers; C497422:KMT2A protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase