Hemostatic changes in patients with end stage renal disease undergoing hemodialysis.
Patients undergoing hemodialysis may show both thrombotic complications and bleeding abnormalities. Hemostatic changes in patients on hemodialysis may result from alterations in vessel wall integrity and platelet function, and reduced blood flow in the native arteriovenous fistula. Vascular complications represent 20-25% of all hospitalizations of patients on hemodialysis. Literature survey revealed that changes in the hemostatic system may play a major role in vascular complications observed in these patients. Thus, it is essential to investigate hemostatic alterations in patients on hemodialysis so that adequate regimes for anticoagulant therapy could be implemented. In this review we discuss hemostatic abnormalities in end stage renal disease patients undergoing hemodialysis.
Rios
Danyelle Romana Alves
DR
Clinical and Toxicological Analysis Department - Faculty of Pharmacy, Federal University of Minas Gerais, Brazil.
Carvalho
Maria das Graças
Md
Lwaleed
Bashir A
BA
Simões e Silva
Ana Cristina
AC
Borges
Karina Braga Gomes
KB
Dusse
Luci Maria Santana
LM
D001775:Blood Circulation; D001792:Blood Platelets / Q000502:physiology; D005342:Fibrinolysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy*; D006435:Renal Dialysis / Q000009:adverse effects*