title: Cytotoxicity of natural compounds isolated from the seeds of Garcinia afzelii.
abstract: The new compounds guttiferone O ( 1) and 3-methoxycheffouxanthone ( 2) have been isolated from the seeds of Garcinia afzelii Engl., together with nine known compounds: 2-hydroxy-1,7-dimethoxyxanthone ( 3), smeathxanthone A ( 4), 1,5-dihydroxyxanthone ( 5), 1,6-dihydroxy-5-methoxyxanthone ( 6), cheffouxanthone ( 7), 1,3,5-trihydroxyxanthone ( 8), smeathxanthone B ( 9), isoxanthochymol ( 10) and guttiferone E ( 11). Their structures were elucidated by means of 1D and 2D-NMR techniques. All the isolates showed high cytotoxic activity and were found inactive when tested against HIV and influenza viruses.
authors: Department of Chemistry, Higher Teachers' Training College, University of Maroua, Maroua, Cameroon.
authors: Alain Meli
authors: AM
authors: Lannang
authors: Gabin Nselapi
authors: GN
authors: Louh
authors: Bernadette Messi
authors: BM
authors: Biloa
authors: Justin
authors: J
authors: Komguem
authors: Celine Djama
authors: CD
authors: Mbazoa
authors: Beiban Luc
authors: BL
authors: Sondengam
authors: Lieve
authors: L
authors: Naesens
authors: Christophe
authors: C
authors: Pannecouque
authors: Erik
authors: E
authors: De Clercq
authors: El H
authors: el H
authors: Sayed El Ashry
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D000998:Antiviral Agents / Q000302:isolation & purification; D001577:Benzophenones / Q000302:isolation & purification*; D004353:Drug Evaluation, Preclinical; D029760:Garcinia / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D044004:Xanthones / Q000302:isolation & purification*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D001577:Benzophenones; D044004:Xanthones; C544371:guttiferone O