The role of tregs in glioma-mediated immunosuppression: potential target for intervention.
The role of regulatory T cells (Tregs) in mediating immune suppression of anti-tumor immune responses is increasingly appreciated in patients with malignancies-especially within the malignant glioma patient population. This article discuss the role and prognostic significance of Tregs within glioma patients and delineates potential approaches for their inhibition that can be used alone or in combination with other immune therapeutics in clinical trials and in the clinical settings of recurrent or residual disease.
Humphries
William
W
Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Wei
Jun
J
Sampson
John H
JH
Heimberger
Amy B
AB
D000818:Animals; D001932:Brain Neoplasms / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D002490:Central Nervous System / Q000276:immunology; D005910:Glioma / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy; D011379:Prognosis; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*