Synthesis, structural characterization and antiproliferative and toxic bio-activities of copper(II) and nickel(II) citronellal N4-ethylmorpholine thiosemicarbazonates.
This paper reports the syntheses and characterization of ethylmorpholine substituted citronellal thiosemicarbazone copper(II) and nickel(II) metal complexes. The compounds were characterized through elemental analyses and spectroscopic (IR, UV-Vis, NMR, MS) methods. The X-ray analysis of the two complexes shows that both Ni and Cu derivatives present a square planar coordination, where the coordinating homologous donor atoms bind in trans to each other. The compounds were tested for their biological activity after determination of their octanol-saline partition coefficients, followed by their radical scavenging properties. Eventually the complexes were tested for their proliferation inhibition on human histiocytic lymphoma U937 cell line. The GI(50) values resulted to be 2.3microM for the copper derivative and 12.3microM for the nickel derivative.
Belicchi-Ferrari
Marisa
M
Dipartimento di Chimica Generale ed Inorganica, Chimica Analitica, Chimica Fisica, Università degli Studi di Parma, 43124 Parma, Italy.
Bisceglie
Franco
F
Buschini
Annamaria
A
Franzoni
Susanna
S
Pelosi
Giorgio
G
Pinelli
Silvana
S
Tarasconi
Pieralberto
P
Tavone
Matteo
M
D000080462:Acyclic Monoterpenes; D000447:Aldehydes / Q000737:chemistry; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008956:Models, Chemical; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry; D009025:Morpholines / Q000737:chemistry; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction / Q000187:drug effects; D010851:Picrates / Q000737:chemistry; D013053:Spectrophotometry; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020298:U937 Cells
D000080462:Acyclic Monoterpenes; D000447:Aldehydes; D000975:Antioxidants; D001713:Biphenyl Compounds; D056831:Coordination Complexes; D039821:Monoterpenes; D009025:Morpholines; D010851:Picrates; D013882:Thiosemicarbazones; D003300:Copper; D009532:Nickel; C037574:morpholine; C004931:1,1-diphenyl-2-picrylhydrazyl; C108217:citronellal