Chelation-assisted palladium-catalyzed cascade bromination/cyanation reaction of 2-arylpyridine and 1-arylpyrazole C-H bonds.
A chelation-assisted palladium-catalyzed cascade bromination/cyanation reaction of 2-arylpyridine and 1-arylpyrazole C-H bonds has been developed. Notably, the reaction employs K(3)[Fe(CN)(6)] as a safe and nontoxic cyanide source, providing aromatic nitriles in moderate to good yields in one-pot. The procedure tolerates methoxy, chloro, fluoro, cyano, trifluoromethyl, and carbomethoxy groups.
Jia
Xiaofei
X
College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325027, PR China.
Yang
Dongpeng
D
Wang
Wenhui
W
Luo
Fang
F
Cheng
Jiang
J
D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D002614:Chelating Agents / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D005292:Ferricyanides / Q000737:chemistry; D054879:Halogenation; D006859:Hydrogen / Q000737:chemistry*; D008956:Models, Chemical; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*
D001555:Benzene Derivatives; D002614:Chelating Agents; D003486:Cyanides; D005292:Ferricyanides; D009570:Nitriles; D011720:Pyrazoles; D011725:Pyridines; D010165:Palladium; D002244:Carbon; D006859:Hydrogen; C028033:potassium ferricyanide