title: Diabetes mellitus is associated with high early-mortality and poor prognosis in patients with autoimmune hemolytic anemia.
abstract: The incidence of autoimmune hemolytic anemia (AIHA) is highest among the elderly, and thus it is frequently associated with co-morbidities such as diabetes mellitus (DM). However, there have been few reports on the impact of these co-morbidities on survival in patients with AIHA. Therefore, we retrospectively reviewed the records of 53 consecutive AIHA patients and assessed the impact of DM on survival. Eighteen of the 53 patients had DM. The estimated 4-year overall survival (4y-OS) for all patients was 84.9%. Infection was the most frequent cause of death, and fatal infections were exclusively observed in patients with DM. The deaths in DM patients occurred frequently within 1 year, to give significantly poor survival (4y-OS; 69.3% versus 93.6%, P=0.0064). The presence of DM was identified as the only significant risk factor for survival. A large prospective investigation is warranted to assess the impact of co-morbidities on survival in patients with AIHA.
authors: Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
authors: Hideki
authors: H
authors: Nakasone
authors: Shinichi
authors: S
authors: Kako
authors: Hiroshi
authors: H
authors: Endo
authors: Ayumu
authors: A
authors: Ito
authors: Miki
authors: M
authors: Sato
authors: Kiriko
authors: K
authors: Terasako
authors: Shinya
authors: S
authors: Okuda
authors: Yukie
authors: Y
authors: Tanaka
authors: Rie
authors: R
authors: Yamazaki
authors: Kumi
authors: K
authors: Oshima
authors: Aki
authors: A
authors: Tanihara
authors: Michiko
authors: M
authors: Kida
authors: Takakazu
authors: T
authors: Higuchi
authors: Koji
authors: K
authors: Izutsu
authors: Junji
authors: J
authors: Nishida
authors: Akio
authors: A
authors: Urabe
authors: Kensuke
authors: K
authors: Usuki
authors: Yoshinobu
authors: Y
authors: Kanda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000401:mortality*; D048909:Diabetes Complications / Q000401:mortality*; D003920:Diabetes Mellitus / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors