title: Prognostic usefulness of lymph node ratio in understaged gastric cancer.
abstract: OBJECTIVE
  Gastric cancer staging based on the number of positive lymph nodes is not reliable in patients undergoing limited lymphadenectomies. The aim of the present study was to determine the prognostic influence of lymph node ratio (LR)--defined as the number of metastatic nodes divided by total of obtained nodes--in patients with less than 16 analyzed lymph nodes.
  
  
  METHODS
  Seventy-two gastric cancer patients underwent surgery with a curative intention, obtaining less than <16 nodes. The pN (TNM 5th Ed) and LR were studied in a multivariate analysis (Cox regression). LR was classified in four groups: 0, <40%, 40-79%, and >80%, according to a previous study carried out by the authors.
  
  
  RESULTS
  Neither the number of affected lymph nodes nor LR behaved as independent prognostic factors. Nevertheless, when locally advanced tumors were studied separately, the lymph node ratio gave more precise prognostic information, resulting in the identification a group of patients with the same pN stage who presented with different prognoses.
  
  
  CONCLUSIONS
  LR offers better prognostic information than the number of affected lymph nodes in patients with locally advanced gastric tumors undergoing limited lymphadenectomies. Further studies are needed to confirm these results and standardize the stratification of LR.
authors: Hospital Mutua de Terrassa, Servicio de Cirugia General y digestiva, Plaça del Doctor Robert 1. 08221 Terrassa, Spain. 25533jrs@comb.es
authors: Joaquin Rodriguez
authors: JR
authors: Santiago
authors: Javier
authors: J
authors: Osorio
authors: Israel
authors: I
authors: Gutierrez
authors: Noelia
authors: N
authors: Perez
authors: Emilio
authors: E
authors: Mufioz
authors: Enrique
authors: E
authors: Veloso
authors: Constancio
authors: C
authors: Marco
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000473:pathology*