title: Malignant appendiceal GIST: case report and review of the literature.
abstract: BACKGROUND
  Gastro-intestinal stromal tumors (GISTs) of the appendix are a rare entity. To date, only a handful has been described in the literature, all of which have been of the benign type.
  
  
  METHODS
  We present the first reported case of a malignant appendiceal GIST. The tumor was discovered when the patient presented with a peri-appendiceal abscess which appeared suspicious on CT. The abscess was drained and managed medically. The patient responded to antibiotic treatment but subsequent CT and biopsy confirmed the diagnosis of appendiceal GIST, and the patient was started on treatment with imatinab mesylate.
  
  
  CONCLUSIONS
  One week after initiation of therapy, the patient returned with frank peritonitis necessitating surgery. Abdominal exploration revealed an appendiceal GIST locally invading and perforating adjacent bowel. We describe the complex presentation and course of the case as well as a literature review of the appendiceal GISTs and the current approach to treatment.
authors: Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors: Ram
authors: R
authors: Elazary
authors: Avraham
authors: A
authors: Schlager
authors: Abed
authors: A
authors: Khalaileh
authors: Liat
authors: L
authors: Appelbaum
authors: Miklosh
authors: M
authors: Bala
authors: Mahmoud
authors: M
authors: Abu-Gazala
authors: Areej
authors: A
authors: Khatib
authors: Tzahi
authors: T
authors: Neuman
authors: Avraham I
authors: AI
authors: Rivkind
authors: Gidon
authors: G
authors: Almogy
mesh_terms: D000038:Abscess / Q000209:etiology / Q000601:surgery; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001063:Appendiceal Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D001549:Benzamides; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D046152:Gastrointestinal Stromal Tumors / Q000150:complications / Q000473:pathology* / Q000628:therapy; D006801:Humans; D006973:Hypertension / Q000150:complications; D000068877:Imatinib Mesylate; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate