title: Assessment of pulsatile wall shear stress in compliant arteries: numerical model, validation and experimental data.
abstract: There is evidence that wall shear stress (WSS) is associated with vascular disease. In particular, it is widely accepted that vascular segments with low or oscillatory values of WSS are more probable to develop vascular disease. It is then necessary to establish a realistic model of the blood flow in blood vessels in order to determine precisely WSS. We proposed a numerical 1D model which takes into account the pulsatile nature of blood flow, the elasticity of the vessel, and its geometry. The model allows the calculation of shear stress. It was validated for stationary situations. Then, we computed the time-dependent WSS distribution from experimental data in the sheep thoracic aorta. Results showed that mean WSS calculated through steady flow and rigid walls models is overestimated. Peak WSS values for pulsatile flow must be considered since they resulted to be at least one order higher than mean values. Oscillations in shear stress in a period showed to be approximately of 40%. These findings show that the proposed model is suitable for estimating time-dependent WSS distributions, and confirm the need of using this kind of model when trying to evaluate realistic WSS in blood vessels.
authors: School of Engineering and Natural and Exact Sciences, Favaloro University, Buenos Aires, Argentina. fsalvucci@favaloro.edu.ar
authors: Fernando P
authors: FP
authors: Salvucci
authors: Carlos A
authors: CA
authors: Perazzo
authors: Juan G
authors: JG
authors: Barra
authors: Ricardo L
authors: RL
authors: Armentano
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology; D001158:Arteries / Q000473:pathology; D001698:Biomedical Engineering / Q000379:methods; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001808:Blood Vessels / Q000473:pathology; D003198:Computer Simulation; D004548:Elasticity; D018056:Hemorheology; D008962:Models, Theoretical; D009991:Oscillometry / Q000379:methods; D011673:Pulsatile Flow; D012756:Sheep; D013314:Stress, Mechanical