Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis.
OBJECTIVE
To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1) gene in patients with spontaneous bacterial peritonitis (SBP).


METHODS
MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.


RESULTS
The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However, in the subgroup of patients with alcoholic cirrhosis (n = 80), carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%, P = 0.021).


CONCLUSIONS
In patients with alcoholic liver cirrhosis, the -2518 MCP-1 genotype AA is a risk factor for the development of SBP.
Gäbele
Erwin
E
Department of Internal Medicine I, University Medical Center Regensburg, Regensburg, Germany.
Mühlbauer
Marcus
M
Paulo
Hartwig
H
Johann
Monika
M
Meltzer
Christin
C
Leidl
Franz
F
Wodarz
Norbert
N
Wiest
Reiner
R
Schölmerich
Jürgen
J
Hellerbrand
Claus
C
D000328:Adult; D000483:Alleles; D001201:Ascites / Q000235:genetics / Q000382:microbiology; D001424:Bacterial Infections / Q000235:genetics* / Q000382:microbiology; D018932:Chemokine CCL2 / Q000235:genetics*; D005260:Female; D005355:Fibrosis / Q000175:diagnosis / Q000235:genetics; D005838:Genotype; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000235:genetics* / Q000382:microbiology; D011110:Polymorphism, Genetic; D012307:Risk Factors
D018932:Chemokine CCL2