Pushing and pulling: microtubules mediate meiotic pairing and synapsis.
Meiotic pairing in the nematode Caenorhabditis elegans is facilitated by chromosomal sites known as pairing centers that are tethered to the nuclear envelope. Sato et al. (2009) and Penkner et al. (2009) provide insight into how proteins linking pairing centers and the microtubule cytoskeleton mediate homolog pairing and restrict synapsis to homologous pairs of chromosomes.
Jaspersen
Sue L
SL
Stowers Institute for Medical Research, Kansas City, MO, USA. slj@stowers.org
Hawley
R Scott
RS
D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D023902:Chromosome Pairing; D002875:Chromosomes / Q000378:metabolism; D008540:Meiosis; D008870:Microtubules / Q000378:metabolism*; D009685:Nuclear Envelope / Q000378:metabolism
D029742:Caenorhabditis elegans Proteins