Lack of evidence of myocardial damage in children with Plasmodium falciparum severe and complicated malaria from an endemic area for endomyocardial fibrosis.
Malaria is among the factors thought to be involved in the pathogenesis of endomyocardial fibrosis (EMF), a restrictive cardiomyopathy of unclear etiology, with no specific therapy, which affects predominantly children and adolescents. In Africa, regions endemic with EMF are also areas with high prevalence of malaria. We studied 47 consecutive children aged 5- to 15-years old and concluded that myocardial damage and dysfunction are rare in severe and complicated Plasmodium falciparum malaria cases in children.
Mocumbi
Ana Olga
AO
Instituto do Coração, Moçambique. amocumbl@yahoo.com
Songane
Mário
M
Salomão
Cristolde
C
Ulibarri
Rogelio
R
Ferreira
Maria Beatriz
MB
Yacoub
Magdi H
MH
D000293:Adolescent; D000818:Animals; D015415:Biomarkers / Q000097:blood; D009202:Cardiomyopathies / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D019353:Endemic Diseases; D004719:Endomyocardial Fibrosis / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000469:parasitology* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007303:Insect Vectors; D016778:Malaria, Falciparum / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D009073:Mozambique / Q000453:epidemiology; D010963:Plasmodium falciparum / Q000302:isolation & purification; D015995:Prevalence; D012189:Retrospective Studies; D020107:Troponin T / Q000097:blood
D015415:Biomarkers; D020107:Troponin T