Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives.
Benzo[b]thiophene molecules are found to be important tools in synthetic medicinal chemistry. They are of current interest due to their wide spectrum of pharmacological properties. In view of the biological activities of benzo[b]thiophene containing molecules, in this present research work, we propose the synthesis of some new benzo[b]thiophene derivatives such as thiadiazoles, oxadiazoles, pyrazolin & diaryl pyrazoles starting from 3-chlorobenzo[b]thiophene-2-carboxyl chloride. These newly synthesized compounds were characterized by elemental analyses, I.R, NMR and Mass spectral studies. Some of the selected compounds were screened for their antibacterial, antifungal and anti-inflammatory studies. Many of the molecules were found to be potent.
Isloor
Arun M
AM
Department of Chemistry, National Institute of Technology-Karnataka, Surathkal, Mangalore 575 025, India. isloor@yahoo.com
Kalluraya
Balakrishna
B
Sridhar Pai
K
K
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy; D005658:Fungi / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013057:Spectrum Analysis; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D013876:Thiophenes; C088015:benzothiophene