title: Clinical experience of patients with ductal carcinoma in situ of the breast treated with breast-conserving surgery plus radiotherapy: a preliminary report.
abstract: OBJECTIVE
  Breast-conserving therapy (BCT) is a practical alternative to mastectomy for treating ductal carcinoma in situ (DCIS). We reviewed our experience for treating patients with DCIS of the breast to evaluate the outcome after performing breast-conserving surgery plus radiotherapy (BCS-RT).
  
  
  METHODS
  Between January 1983 and December 2002, 25 patients with clinically or mammographically detected DCIS were treated by BCS-RT. One patient was diagnosed with bilateral DCIS. Thirteen cases (50%) had symptomatic lesions at presentation. All 26 cases of 25 patients underwent BCS such as lumpectomy, partial mastectomy or quadrantectomy. All of them received whole breast irradiation to a median dose of 50.4 Gy. Twenty-four cases (92.3%) received a boost to the tumor bed for a median total dose of 59.4 Gy. The median follow up period was 67 months (range: 38 to 149 months).
  
  
  RESULTS
  Two cases (7.7%) experienced ipsilateral breast tumor recurrence (IBTR) after BCS-RT. The histology results at the time of IBTR showed invasive ductal carcinoma (IDC), and the median time to IBTR was 25.5 months. On the univariate analysis, there were no significant factors associated with IBTR in the DCIS patients. The three-year local recurrence free survival rate was 96.0% and the overall survival rate was 96.3%.
  
  
  CONCLUSIONS
  After the treatment for DCIS, the IBTR rate in our study was similar to other previous studies. Considering that we included patients who had many symptomatic lesions, close or positive margins and less that complete early data, our result is comparable to the previous studies. We could not find the prognostic significant factors associated with IBTR after BCS-RT. A longer follow up period with more patients would be required to evaluate the role of any predictive factors and to confirm these short-term results.
authors: Department of Radiation Oncology, Chosun University Hospital, Gwangju, Korea.
authors: Ji-Young
authors: JY
authors: Jang
authors: Mi-Ryeong
authors: MR
authors: Ryu
authors: Sung-Whan
authors: SW
authors: Kim
authors: Chul-Seung
authors: CS
authors: Kay
authors: Yeon-Sil
authors: YS
authors: Kim
authors: Yoon-Kyeong
authors: YK
authors: Oh
authors: Hyung-Chul
authors: HC
authors: Kwon
authors: Sei-Chul
authors: SC
authors: Yoon
authors: Woo-Chan
authors: WC
authors: Park
authors: Byung-Joo
authors: BJ
authors: Song
authors: Se-Jeong
authors: SJ
authors: Oh
authors: Sang-Seol
authors: SS
authors: Jung
authors: Jong-Man
authors: JM
authors: Won
authors: Seung-Nam
authors: SN
authors: Kim
authors: Su-Mi
authors: SM
authors: Chung