The antioxidant properties of carnitine in vitro.
Many of the effects of carnitine are ascribed to its antioxidant properties. The aim of this study was to evaluate the antioxidant properties of carnitine in vitro. Carnitine was found to decolorize ABTS(*+), and to protect fluorescein against bleaching induced by AAPH-derived peroxyl radicals and peroxynitrite, thiol groups against oxidation induced by hydrogen peroxide, peroxyl radicals, hypochlorite and peroxynitrite, and erythrocytes against hemolysis induced by peroxyl radicals and hypochlorite. These results show that carnitine has a direct antioxidant action against physiologically relevant oxidants.
Solarska
Katarzyna
K
Department of Biochemistry and Cell Biology, University of Rzeszów, Pigonia 6, 35-959, Rzeszów, Poland.
Lewińska
Anna
A
Karowicz-Bilińska
Agata
A
Bartosz
Grzegorz
G
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D052160:Benzothiazoles / Q000737:chemistry / Q000378:metabolism; D002331:Carnitine / Q000737:chemistry / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D006461:Hemolysis; D006997:Hypochlorous Acid / Q000378:metabolism; D010545:Peroxides / Q000378:metabolism; D030421:Peroxynitrous Acid / Q000378:metabolism; D013451:Sulfonic Acids / Q000737:chemistry / Q000378:metabolism
D000975:Antioxidants; D052160:Benzothiazoles; D010545:Peroxides; D013451:Sulfonic Acids; D030421:Peroxynitrous Acid; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C049375:perhydroxyl radical; D006997:Hypochlorous Acid; D002331:Carnitine