title: Inhibitors target actin nucleators.
abstract: In this issue of Chemistry and Biology, Rizvi and colleagues indentify a small molecule that inhibits formin-mediated actin assembly. Together with recently characterized inhibitors of the Arp2/3 complex (Nolen et al., 2009) and formins (Gauvin et al., 2009), these small molecules provide useful laboratory tools to dissect the link between actin nucleators and actin-based structures in living cells.
authors: Institut de Recherches en Technologies et Sciences pour le Vivant, CNRS/CEA/INRA/UJF, Grenoble, France. laurent.blanchoin@cea.fr
authors: Laurent
authors: L
authors: Blanchoin
authors: Rajaa
authors: R
authors: Boujemaa-Paterski
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism; D000199:Actins / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D045744:Cell Line, Tumor; D003599:Cytoskeleton / Q000187:drug effects; D006801:Humans; D051379:Mice; D008840:Microfilament Proteins / Q000037:antagonists & inhibitors*; D041681:NIH 3T3 Cells; D017434:Protein Structure, Tertiary; D011744:Pyrimidinones / Q000737:chemistry / Q000494:pharmacology; D054852:Small Molecule Libraries; D013871:Thiones / Q000737:chemistry / Q000494:pharmacology*; D014498:Uracil / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D051376:Actin-Related Protein 2-3 Complex; D000199:Actins; D008840:Microfilament Proteins; D011744:Pyrimidinones; D054852:Small Molecule Libraries; D013871:Thiones; D014498:Uracil