Genetic influences on the cognitive biases associated with anxiety and depression symptoms in adolescents.
BACKGROUND
There is a substantial overlap between genes affecting anxiety and depression. Both anxiety and depression are associated with cognitive biases such as anxiety sensitivity and attributional style. Little, however, is known about the relationship between these variables and whether these too are genetically correlated.


METHODS
Self-reports of anxiety sensitivity, anxiety symptoms, attributional style and depression symptoms were obtained for over 1300 adolescent twin and sibling pairs at two time points. The magnitude of genetic and environmental influences on the measures was examined.


RESULTS
Strongest associations were found between anxiety sensitivity and anxiety ratings at both measurement times (r=.70, .72) and between anxiety and depression (r=.62 at both time points). Correlations between the cognitive biases were modest at time 1 (r=-.12) and slightly larger at time 2 (r=-.31). All measures showed moderate genetic influence. Generally genetic correlations reflected phenotypic correlations. Thus the highest genetic correlations were between anxiety sensitivity and anxiety ratings (.86, .87) and between anxiety and depression ratings (.77, .71). Interestingly, depression ratings also showed a high genetic correlation with anxiety sensitivity (.70, .76). Genetic correlations between the cognitive bias measures were moderate (-.31, -.46).


CONCLUSIONS
The sample consists primarily of twins, there are limitations associated with the twin design.


CONCLUSIONS
Cognitive biases associated with depression and anxiety are not as genetically correlated as anxiety and depression ratings themselves. Further research into the cognitive processes related to anxiety and depression will facilitate understanding of the relationship between bias and symptoms.
Zavos
Helena M S
HM
Social, Genetic, & Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, United Kingdom. Helena.zavos@kcl.ac.uk
Rijsdijk
Frühling V
FV
Gregory
Alice M
AM
Eley
Thalia C
TC
D000293:Adolescent; D001008:Anxiety Disorders / Q000235:genetics* / Q000523:psychology; D002648:Child; D003072:Cognition Disorders / Q000235:genetics* / Q000523:psychology; D003866:Depressive Disorder / Q000235:genetics* / Q000523:psychology; D004200:Diseases in Twins / Q000235:genetics* / Q000523:psychology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007389:Internal-External Control; D008137:Longitudinal Studies; D008297:Male; D010641:Phenotype; D012931:Social Environment; D013223:Statistics as Topic; D006113:United Kingdom; D055815:Young Adult