title: A comprehensive cardiopulmonary simulation model for the analysis of hypercapnic respiratory failure.
abstract: We developed a new comprehensive cardiopulmonary model that takes into account the mutual interactions between the cardiovascular and the respiratory systems along with their short-term regulatory mechanisms. The model includes the heart, systemic and pulmonary circulations, lung mechanics, gas exchange and transport equations, and cardio-ventilatory control. Results show good agreement with published patient data in case of normoxic and hyperoxic hypercapnia simulations. In particular, simulations predict a moderate increase in mean systemic arterial pressure and heart rate, with almost no change in cardiac output, paralleled by a relevant increase in minute ventilation, tidal volume and respiratory rate. The model can represent a valid tool for clinical practice and medical research, providing an alternative way to experience-based clinical decisions.
authors: Philips Research North America, Briarcliff Manor, NY 10510, USA. chbat@philips.com
authors: Nicolas W
authors: NW
authors: Chbat
authors: Massimo
authors: M
authors: Giannessi
authors: Antonio
authors: A
authors: Albanese
authors: Mauro
authors: M
authors: Ursino
mesh_terms: D001794:Blood Pressure; D003198:Computer Simulation; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D006935:Hypercapnia / Q000150:complications / Q000503:physiopathology*; D008168:Lung / Q000503:physiopathology*; D008954:Models, Biological; D011659:Pulmonary Gas Exchange; D012131:Respiratory Insufficiency / Q000209:etiology / Q000503:physiopathology*