Chemo-enzymatic synthesis and functional analysis of natural and modified glycostructures.
The advancing field of glycomics is driven by the development of new analysis and synthesis techniques and novel strategies such as metabolic glyco-labeling. In this review we will present strategies for tailoring chemo-enzymatic glycosyltransfer reactions, screening methods such as carbohydrate-based micro-arrays, and metabolic glyco-engineering as a strategy to visualize biological recognition processes for the development of carbohydrate-based vaccines.
Homann
Arne
A
Department of Organic Chemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.
Seibel
Jürgen
J
D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D006027:Glycosides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D016695:Glycosyltransferases / Q000378:metabolism*; D015394:Molecular Structure
D001688:Biological Products; D006027:Glycosides; D016695:Glycosyltransferases