Ifosfamide-induced encephalopathy and movement disorder.
Ifosfamide is a widely used chemotherapeutic agent for the treatment of a broad spectrum of solid tumors. CNS toxicity is a well-described side effect of ifosfamide, but the mechanism of ifosfamide-induced neurotoxicity remains poorly defined. We present two pediatric cases of hemiballismic limb movements in the setting of ifosfamide-associated encephalopathy. To our knowledge, there have been no prior reports of ifosfamide-induced hemiballism in pediatric patients. One of our patient's encephalopathy and abnormal movements may have improved after the administration of methylene blue and thiamine.
Ames
Bethany
B
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA. bethany.l.ames@hitchcock.org
Lewis
Lionel D
LD
Chaffee
Sara
S
Kim
Julie
J
Morse
Richard
R
D000293:Adolescent; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy; D001927:Brain Diseases / Q000139:chemically induced*; D002648:Child; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects*; D008297:Male; D009069:Movement Disorders / Q000209:etiology*; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D012516:Osteosarcoma / Q000188:drug therapy
D018906:Antineoplastic Agents, Alkylating; D007069:Ifosfamide