title: Missense mutation of Abcg5 in stroke-prone spontaneously hypertensive rats does not influence lymphatic sitosterol absorption regardless of the dose: comparison with Wistar rats.
abstract: The lymphatic recovery of radiolabeled sitosterol administered in various amounts to the stomach was almost the same between stroke-prone spontaneously hypertensive rats (SHRSPs), a strain having a missense mutation in ATP binding cassette transporter g5 (Abcg5), and Wistar rats, a normal strain. The results suggest that the mutation of Abcg5 in SHRSPs, compared with Wistar rats, did not influence the ability for intestinal sitosterol absorption regardless of the dose.
authors: Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
authors: Tadateru
authors: T
authors: Hamada
authors: Yoko
authors: Y
authors: Kodama
authors: Katsumi
authors: K
authors: Imaizumi
authors: Ikuo
authors: I
authors: Ikeda
mesh_terms: D000071018:ATP Binding Cassette Transporter, Subfamily G, Member 5; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000042:Absorption; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000378:metabolism; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism*; D008074:Lipoproteins / Q000235:genetics*; D008208:Lymphatic System / Q000378:metabolism*; D008297:Male; D020125:Mutation, Missense; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D012855:Sitosterols / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D020521:Stroke
chemical_list: D000071018:ATP Binding Cassette Transporter, Subfamily G, Member 5; D018528:ATP-Binding Cassette Transporters; C480692:Abcg5 protein, rat; D008074:Lipoproteins; D012855:Sitosterols; C025473:gamma-sitosterol