title: Effects of leg blood flow restriction during walking on cardiovascular function.
abstract: BACKGROUND
  Exercise with limb blood flow restriction (BFR) is a very popular exercise modality in Japan and is spreading widely to the rest of the world. The underlying principle of this training modality is that under the conditions of restricted blood flow, even low-intensity exercise can provide significant muscle strength and hypertrophy. One concern, however, is that BFR during exercise may place unnecessary burden on those with compromised cardiac function.
  
  
  METHODS
  We determined the impact of leg BFR during walking on cardiovascular function in 17 young (26 ± 1 yr) healthy volunteers. Each subject underwent five bouts of 2-min treadmill walking at 2 miles·h(-1) with 1-min interval either with or without tourniquet cuffs inflated on both thighs.
  
  
  RESULTS
  Heart rate increased more during the BFR session, whereas stroke volume decreased greater during the BFR session. Blood pressure increased significantly and substantially during the BFR session. Consequently, an increase in double product, an index of myocardial oxygen demand, was more than threefold higher in the BFR condition. Systemic arterial compliance evaluated by stroke volume/pulse pressure ratio significantly increased during the control session by 14% but reduced during the BFR condition by 19%. Popliteal artery flow-mediated vasodilation decreased significantly after the exercise with BFR but not after the control session.
  
  
  CONCLUSIONS
  Even at low intensity, the aerobic exercise with BFR requires a greater cardiac work and decreases endothelial function. Limb BFR during exercise may need to be more cautiously prescribed to those with compromised cardiac conditions.
authors: Cardiovascular Aging Research Laboratory, Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, USA.
authors: Christopher P
authors: CP
authors: Renzi
authors: Hirofumi
authors: H
authors: Tanaka
authors: Jun
authors: J
authors: Sugawara
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D005080:Exercise Test / Q000379:methods; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007511:Ischemia / Q000209:etiology*; D007564:Japan; D007866:Leg / Q000098:blood supply*; D008297:Male; D012039:Regional Blood Flow / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology; D014111:Tourniquets; D016138:Walking / Q000502:physiology*; D055815:Young Adult