title: Enhanced cell permeability of kojic acid-phenylalanine amide with metal complex.
abstract: Kojic acid-phenylalanine amide (KA-F-NH(2)), which showed an excellent tyrosinase inhibitory activity, did not inhibit melanogenesis in melanocyte due to its low cell permeability. To enhance its cell permeability by increasing lipophilicity, we prepared metal coordination compounds of KA-F-NH(2) and characterized them by FT-IR and ICP analysis. The metal complex of KA-F-NH(2) inhibited mushroom tyrosinase activity as much as KA-F-NH(2) and reduced melanin contents in melanocyte efficiently.
authors: School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea.
authors: Seon-Yeong
authors: SY
authors: Kwak
authors: Jin-Mi
authors: JM
authors: Noh
authors: So-Hee
authors: SH
authors: Park
authors: Jang-Woong
authors: JW
authors: Byun
authors: Hye-Ryung
authors: HR
authors: Choi
authors: Kyoung-Chan
authors: KC
authors: Park
authors: Yoon-Sik
authors: YS
authors: Lee
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002463:Cell Membrane Permeability / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008543:Melanins / Q000378:metabolism; D051379:Mice; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry; D011753:Pyrones / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D056831:Coordination Complexes; D008543:Melanins; D011753:Pyrones; D010649:Phenylalanine; C020457:phenylalanine amide; C011890:kojic acid; D014442:Monophenol Monooxygenase