title: Tryptase is not cleared by the kidneys into the urine.
abstract: BACKGROUND
  Patients with chronic kidney disease have been reported to have increased concentrations of blood tryptase. Detection of tryptase in the urine of healthy subjects has been reported.
  
  
  OBJECTIVE
  The objective is to determine whether tryptase is indeed cleared by the kidneys.
  
  
  METHODS
  Blood and urine collections were performed in healthy and systemic mastocytosis subjects. Total and mature tryptase concentrations in blood and total tryptase concentrations in urine were determined.
  
  
  RESULTS
  Total tryptase levels in urine were below the limit of detection in both healthy subjects and those with systemic mastocytosis, even after concentrating the urine 10-fold. Thus, both mature and protryptase levels in urine are <0.2 ng/ml.
  
  
  CONCLUSIONS
  Tryptase is not cleared by the kidneys into the urine.
authors: Allergy and Immunology Section, William Beaumont Hospital, Royal Oak, MI 48073, USA. mrsimonmd@sbcglobal.net
authors: Michael R
authors: MR
authors: Simon
authors: Mindy
authors: M
authors: Jan
authors: Jerry
authors: J
authors: Yee
authors: Uday S
authors: US
authors: Nori
authors: Jiang
authors: J
authors: Hu
authors: Cem
authors: C
authors: Akin
authors: Lawrence B
authors: LB
authors: Schwartz
mesh_terms: D000707:Anaphylaxis / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D034721:Mastocytosis, Systemic / Q000378:metabolism; D053802:Tryptases / Q000097:blood* / Q000652:urine*
chemical_list: D053802:Tryptases