Sesamol down-regulates the lipopolysaccharide-induced inflammatory response by inhibiting nuclear factor-kappa B activation.
We examined the effects of sesamol on the lipopolysaccharide (LPS)-induced inflammatory response. Sesamol inhibited serum tumor necrosis factor (TNF)-α, interleukin (IL)-1β and nitrite production in LPS-treated mice, and inhibited LPS-induced inducible nitric oxide synthase expression in mouse leukocytes. Sesamol also down-regulated TNF-α, IL-1β, and nitrite production as well as inducible nitric oxide synthase expression in LPS-treated RAW 264.7 cells. Further, sesamol inhibited LPS-induced nuclear factor (NF)-κB translocation and inhibitor (I)κB-α phosphorylation in RAW 264.7 cells. By inhibiting TNF-α, IL-1β, and nitrite levels, and interfering with the NFκB pathway, sesamol down-regulated the LPS-initiated inflammatory response.
Chu
Pei-Yi
PY
Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.
Hsu
Dur-Zong
DZ
Hsu
Pin-Yen
PY
Liu
Ming-Yie
MY
D000818:Animals; D052117:Benzodioxoles / Q000008:administration & dosage* / Q000494:pharmacology; D002460:Cell Line; D015536:Down-Regulation; D018836:Inflammation Mediators / Q000378:metabolism; D053583:Interleukin-1beta / Q000235:genetics / Q000378:metabolism; D008070:Lipopolysaccharides / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D016328:NF-kappa B / Q000276:immunology / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II / Q000235:genetics / Q000378:metabolism; D010636:Phenols / Q000008:administration & dosage* / Q000494:pharmacology; D015533:Transcriptional Activation / Q000187:drug effects / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
D052117:Benzodioxoles; D018836:Inflammation Mediators; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D016328:NF-kappa B; D010636:Phenols; D014409:Tumor Necrosis Factor-alpha; C025583:sesamol; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse