title: Systemic chemotherapy and its implications for resection of colorectal liver metastasis.
abstract: BACKGROUND
  Liver resection remains the only chance of cure for patients with colorectal liver metastasis. Modern chemotherapy can play a role in the management of these patients but is not without risk.
  
  
  METHODS
  The online databases Medline and Pubmed were searched to identify relevant articles. Keywords used in these searches were "colorectal cancer", "liver metastasis", "chemotherapy", "liver resection", "monoclonal antibody", "steatohepatitis", "sinusoidal obstruction" and "liver regeneration". Databases were searched for the period January 1970 to September 2009 inclusively. In addition hand referencing of retrieved articles was performed.
  
  
  RESULTS
  Modern chemotherapy regimens can effectively downstage initially unresectable disease such that surgical resection can be performed with the prospect of long term cure. There is insufficient evidence however to recommend its use in either the neoadjuvant or adjuvant setting in those with resectable disease from the outset.
  
  
  CONCLUSIONS
  Chemotherapy can be associated with significant changes to the hepatic parenchyma with subsequent increased risk of morbidity and mortality in the perioperative period. Much work needs to be done to understand the molecular mechanisms underlying these changes to make extended resections safer in patients who are at risk.
authors: Department of Hepatopancreatobiliary and Transplantation Surgery, The Freeman Hospital, Newcastle upon Tyne, Tyne and Wear, England. sturobinson@doctors.org.uk
authors: S
authors: S
authors: Robinson
authors: D M
authors: DM
authors: Manas
authors: I
authors: I
authors: Pedley
authors: D
authors: D
authors: Mann
authors: S A
authors: SA
authors: White
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D011379:Prognosis