[TGF-beta/Smad in prostate cancer: an update].
Tumorigenesis and cancer progression are closely associated with the transforming growth factor-beta (TGF-beta) and its downstream component Smad. The TGF-beta/Smad signaling pathway, which is activated in prostate cancer, has a regulatory effect on cell adhesion, the actin filament system and cell cycle, as well as the expression of specific genes. Meanwhile, other protein signals such as MAPK and PI3K/Akt/mTOR and some genes may act on the expression of the TGF-beta/Smad pathway. This article updates recent researches on the expression, action and regulatory effect of the TGF-beta/Smad signaling pathway in prostate cancer.
Zha
Ji
J
PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
Huang
Yu-feng
YF
D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism*; D015398:Signal Transduction; D051785:Smad Proteins / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D051785:Smad Proteins; D016212:Transforming Growth Factor beta