An algorithm for managing warfarin resistance.
Some patients need higher-than-expected doses of warfarin (Coumadin) to get their international normalized ratio (INR) into the therapeutic range. The cause of warfarin resistance can be either acquired (eg, poor compliance, drug interactions, dietary interactions) or hereditary, but the genetic mechanisms of warfarin resistance are not well understood. This review offers an algorithm for the evaluation of patients with suspected warfarin resistance.
Osinbowale
Olusegun
O
Department of Cardiovascular Medicine, Section of Vascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Al Malki
Monzr
M
Schade
Andrew
A
Bartholomew
John R
JR
D000465:Algorithms; D000925:Anticoagulants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring / Q000379:methods*; D004351:Drug Resistance; D006801:Humans; D014859:Warfarin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
D000925:Anticoagulants; D014859:Warfarin