Severe atopic dermatitis treated with everolimus.
BACKGROUND
Patients with severe atopic dermatitis (AD) often require treatment with oral immunosuppressive drugs. Everolimus is a rapamycin-derived macrolide with immunosuppressive and antiproliferative effects. Everolimus demonstrated efficacy not only in the prophylaxis of organ rejection in kidney transplant patients, but also in decreasing disease activity in psoriasis patients.


OBJECTIVE
To evaluate whether everolimus is an effective treatment in patients with severe AD.


METHODS
Two patients with severe AD were treated with everolimus in combination with low-dose cyclosporin A (CsA) or prednisone. During treatment, a disease activity and safety laboratory examination was performed.


RESULTS
Everolimus either in combination with prednisone or with CsA did not result in improvement of disease activity in two patients with severe AD.


CONCLUSIONS
Everolimus does not seem to be an effective treatment in these two AD patients, either in combination with prednisone or with CsA.
Van Velsen
Sara Gertrudes Anna
SG
Department of Dermatology and Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands. s.g.a.vanvelsen@umcutrecht.nl
Haeck
Inge Marjet
IM
Bruijnzeel-Koomen
Catharina Ansfrieda Francisca Maria
CA
D016572:Cyclosporine / Q000627:therapeutic use; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000473:pathology*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D000068338:Everolimus; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008875:Middle Aged; D012720:Severity of Illness Index; D020123:Sirolimus / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017211:Treatment Failure
D003879:Dermatologic Agents; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D000068338:Everolimus; D020123:Sirolimus