Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents.
A series of N-alkylated derivatives of nitroimidazolyl oxazolidinones 6a-i with various substituent at N-1 position of the nitroimidazole were synthesized and their in-vitro antibacterial activities were evaluated against several Gram-positive and Gram-negative bacteria. The 6a was found to be most potent compound in the series with MIC at 0.097 microg/mL against Bacillus cereus MTCC 430.). Both 6a and 6f did not exhibit any toxicity towards mammalian cell L929.
Varshney
Vandana
V
Medicinal & Process Chemistry Division, Central Drug Research Institute, MG Road, PB No 173, Lucknow 226001, India.
Mishra
Nripendra N
NN
Shukla
Praveen K
PK
Sahu
Devi P
DP
D000478:Alkylation; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D024881:Drug Resistance, Bacterial; D051379:Mice; D009593:Nitroimidazoles / Q000737:chemistry*; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity
D000900:Anti-Bacterial Agents; D009593:Nitroimidazoles; D023303:Oxazolidinones