title: Administration of human immunoglobulin suppresses development of murine systemic vasculitis induced with Candida albicans water-soluble fraction: an animal model of Kawasaki disease.
abstract: We investigated the inhibitory effect of human immunoglobulin (h-Ig) on the development of coronary arteritis in a murine model of vasculitis induced with a Candida albicans water-soluble fraction (CAWS). CAWS was intraperitoneally injected to C57BL/6 mice for 5 days. Then h-Ig was administered according to various schedules. The animals were sacrificed in week 5, and the status of vasculitis in the coronary arteries and the aortic root was investigated histologically. The groups in which h-Ig was administered for 5 days from day 3 and from day 5 of the experiment showed a significant reduction in the incidence of panvasculitis. In addition, the scope and severity of the inflammation of the aortic root and the coronary arteries were reduced in both groups. In the group administered h-Ig for 5 days from day 1 and the group administered a high dose of h-Ig once on day 1 or day 3, no suppression of development of vasculitis was observed. The h-Ig acted by suppressing the generation and progression of vasculitis in this CAWS-induced murine vasculitis model.
authors: Department of Pathology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro, Tokyo, 153-8515, Japan. keitak@oha.toho-u.ac.jp
authors: Kei
authors: K
authors: Takahashi
authors: Toshiaki
authors: T
authors: Oharaseki
authors: Yuki
authors: Y
authors: Yokouchi
authors: Noriko N
authors: NN
authors: Miura
authors: Naohito
authors: N
authors: Ohno
authors: Akiko I
authors: AI
authors: Okawara
authors: Hisao
authors: H
authors: Murata
authors: Shiro
authors: S
authors: Naoe
authors: Kazuo
authors: K
authors: Suzuki
mesh_terms: D000818:Animals; D000946:Antigens, Fungal; D001167:Arteritis / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D002176:Candida albicans; D003324:Coronary Artery Disease / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D004195:Disease Models, Animal; D006801:Humans; D007116:Immunization, Passive; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D009080:Mucocutaneous Lymph Node Syndrome / Q000276:immunology*; D013997:Time Factors
chemical_list: D000946:Antigens, Fungal; D016756:Immunoglobulins, Intravenous