title: Reduction in systemic and VLDL triacylglycerol concentration after a 3-month Mediterranean-style diet in high-cardiovascular-risk subjects.
abstract: The first results of the PREDIMED (PREvencion con Dieta MEDiterranea) randomized trial, after 3-month intervention, showed that the Mediterranean Diet (MD), supplemented with either virgin olive oil (VOO) or nuts, reduced systolic blood pressure, serum cholesterol and triacylglycerol (TG) concentrations and increased high-density lipoprotein (HDL)-cholesterol when compared to a control (low-fat diet) group. Serum TG levels are an independent risk factor for coronary heart disease and are strongly determined by very low-density lipoprotein (VLDL) composition, which can be specifically modified by dietary lipid source. Within the context of the PREDIMED study, we assessed the VLDL composition in 50 participants after 3 months of intake of two MD, supplemented with VOO or nuts, compared with a low-fat diet. Total and low-density lipoprotein cholesterol concentrations were reduced in subjects on the MD+nuts, whereas HDL-cholesterol increased after consumption of the MD+VOO. Serum TG concentrations were significantly lowered in both intervention groups (either the MD+nuts or MD+VOO). However, only the MD+VOO reduced the VLDL-cholesterol and VLDL-TG content and the TG/apolipoprotein B ratio in VLDL, which was used to estimate particle size. Although VLDL-TG fatty acids were very slightly modified, VLDL-TG molecular species in VLDL after consumption of the MD+nuts were characterized by a higher presence of linoleic acid (18:2, n-6), whereas after the intake of MD+VOO, they were rich in oleic acid (18:1, n-9). Therefore, we conclude that the reduction in systemic TG concentrations observed after consumption of the MD may be explained by reduction of the lipid core of VLDL and a selective modification of the molecular species composition in the particle.
authors: Instituto de la Grasa, Consejo Superior de Investigaciones Cientificas, Sevilla, Spain.
authors: Javier S
authors: JS
authors: Perona
authors: María-Isabel
authors: MI
authors: Covas
authors: Montserrat
authors: M
authors: Fitó
authors: Rosana
authors: R
authors: Cabello-Moruno
authors: Fernando
authors: F
authors: Aros
authors: Dolores
authors: D
authors: Corella
authors: Emilio
authors: E
authors: Ros
authors: Maria
authors: M
authors: Garcia
authors: Ramon
authors: R
authors: Estruch
authors: Miguel A
authors: MA
authors: Martinez-Gonzalez
authors: Valentina
authors: V
authors: Ruiz-Gutierrez
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology*; D038441:Diet, Mediterranean; D004041:Dietary Fats / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008079:Lipoproteins, VLDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009754:Nuts; D000069463:Olive Oil; D010938:Plant Oils / Q000494:pharmacology; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D004041:Dietary Fats; D008079:Lipoproteins, VLDL; D000069463:Olive Oil; D010938:Plant Oils; D014280:Triglycerides; C030106:very low density lipoprotein triglyceride