title: [Preanalytical guidelines for clinical proteomics investigation of biological fluids].
abstract: Research of new diagnosis or prognosis biomarkers is a major challenge for the management of patients with complex pathologies like cancer. Clinical proteomics is one of the recent approaches to identify these biomarkers in biological fluids. Over the last five years, many problems related to the variability and the quality control of these analyses have been observed. This was notably related to the different preanalytical status of each sample. A strong need for standardization of the critical preanalytical phases (collection, transport, processing, storage...) has been therefore recognized. With this goal in mind, working groups of the "Institut national du cancer" (INCa) and the "Société française de biologie clinique" (SFBC) proposed here preanalytical proteomics guidelines for the most common biological fluids: plasma, serum, urine and cerebrospinal fluid. To goal is to provide the basis for the harmonization of the procedures in clinical laboratories and biobanks to allow an optimal use of biological collections.
authors: CHRU de Montpellier, Laboratoire de biochimie, Hôpital Saint Eloi, Montpellier, France. s-lehmann@chu-montpellier.fr
authors: S
authors: S
authors: Lehmann
authors: S
authors: S
authors: Roche
authors: Y
authors: Y
authors: Allory
authors: A
authors: A
authors: Barthelaix
authors: J-L
authors: JL
authors: Beaudeux
authors: F
authors: F
authors: Berger
authors: F
authors: F
authors: Betsou
authors: J
authors: J
authors: Borg
authors: A
authors: A
authors: Dupuy
authors: J
authors: J
authors: Garin
authors: M
authors: M
authors: Quillard
authors: G
authors: G
authors: Lizard
authors: K
authors: K
authors: Peoc'h
authors: M
authors: M
authors: Riviere
authors: P
authors: P
authors: Ducoroy
mesh_terms: D001774:Blood Chemical Analysis / Q000592:standards; D001826:Body Fluids / Q000502:physiology*; D019411:Clinical Laboratory Techniques / Q000592:standards*; D019937:Diagnostic Techniques and Procedures / Q000592:standards*; D006801:Humans; D017410:Practice Guidelines as Topic; D011379:Prognosis; D011507:Proteinuria / Q000175:diagnosis; D040901:Proteomics / Q000379:methods* / Q000592:standards; D014556:Urine / Q000737:chemistry