title: The continuous real-time 13C-octanoate breath test for patients with nonalcoholic steatohepatitis using the BreathID system.
abstract: OBJECTIVE
  Hepatic mitochondrial beta-oxidation is considered to play a pivotal role in the pathogenesis of nonalcoholic steatohepatitis (NASH). The aim of this study was to determine whether there were differences between patients with NASH and healthy controls in a breath test with 13C-octanoate, a medium-chain fatty acid.
  
  
  METHODS
  The subjects were 8 patients (5 men, 3 women, median age 46.5 years) with histologically proven NASH and 6 healthy controls (5 men, 1 women, and median age 27.8 years). The 13C breath test was performed for 4 hours using the BreathID system with a 100 mL of water containing 100 mg 13C-octanoate.
  
  
  RESULTS
  There were no significant differences between NASH patients and controls about all breath test parameters.
  
  
  CONCLUSIONS
  NASH-mediated changes in breath test parameters after ingestion of 13C-octanoate were not observed in our study. The present study findings suggest the possible preservation of 13C-octanoate metabolism (mitochondrial beta-oxidation) in patients with NASH.
authors: Gastroenterology Division, Yokohama City University School of Medicine, Yokohama, Japan.
authors: Hironori
authors: H
authors: Mawatari
authors: Masahiko
authors: M
authors: Inamori
authors: Koji
authors: K
authors: Fujita
authors: Masato
authors: M
authors: Yoneda
authors: Hiroshi
authors: H
authors: Iida
authors: Hiroki
authors: H
authors: Endo
authors: Kunihiro
authors: K
authors: Hosono
authors: Yuichi
authors: Y
authors: Nozaki
authors: Kyoko
authors: K
authors: Yoneda
authors: Tomoyuki
authors: T
authors: Akiyama
authors: Hirokazu
authors: H
authors: Takahashi
authors: Ayumu
authors: A
authors: Goto
authors: Yasunobu
authors: Y
authors: Abe
authors: Hiroyuki
authors: H
authors: Kirikoshi
authors: Noritoshi
authors: N
authors: Kobayashi
authors: Kensuke
authors: K
authors: Kubota
authors: Satoru
authors: S
authors: Saito
authors: Atsushi
authors: A
authors: Nakajima
mesh_terms: D000328:Adult; D001944:Breath Tests / Q000379:methods*; D002210:Caprylates / Q000378:metabolism*; D002247:Carbon Isotopes; D005234:Fatty Liver / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002210:Caprylates; D002247:Carbon Isotopes; C031492:octanoic acid