title: Reproductive hormones in relation to polycyclic aromatic hydrocarbon (PAH) metabolites among non-occupational exposure of males.
abstract: A limited number of studies have suggested that exposure to PAHs may affect reproductive hormones. Subjects (n=642) in this study were from the affiliated hospitals of Nanjing Medical University. Individual exposures to PAHs were measured as spot urinary concentrations of four PAH metabolites, including 1-naphthol (1-N), 2-naphthol (2-N), 2-hydroxyfluorene (2-OF) and 1-hydroxypyrene (1-OP), which were adjusted by urinary creatinine (CR). Blood samples were collected to measure serum levels of reproductive hormones, including follicle-stimulating hormone (FSH), luteotrophic hormone (LH), estradiol (E2), testosterone (T) and prolactin (PRL). All of the subjects had detectable levels of the four metabolites of PAHs in their urine samples. The median concentrations of 1-N, 2-N, 2-OF and 1-OP were 2.440, 4.176, 2.843 and 1.148 microg/g of CR. There were significant P-values between increased CR-adjusted 1-N tertiles and E2 concentration, 2-OF tertiles and LH, FSH level, 1-OP and E2 level. The multivariate linear regression results also showed significant correlation between the levels of serum LH and 1-OP (the adjusting P-value was 0.048), but no correlations were found between other hormones and the level of PAH metabolites. These observed correlations between levels of hydroxy-PAH and some altered hormones indicated slight endocrine effects on adult men with PAH exposure.
authors: National Center for STD Control, Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, Nanjing, PR China.
authors: Yan
authors: Y
authors: Han
authors: Yankai
authors: Y
authors: Xia
authors: Pengfei
authors: P
authors: Zhu
authors: Shanlei
authors: S
authors: Qiao
authors: Rencheng
authors: R
authors: Zhao
authors: Nianzu
authors: N
authors: Jin
authors: Shoulin
authors: S
authors: Wang
authors: Ling
authors: L
authors: Song
authors: Guangbo
authors: G
authors: Fu
authors: Xinru
authors: X
authors: Wang
mesh_terms: D000328:Adult; D002681:China; D004781:Environmental Exposure / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods*; D004958:Estradiol / Q000097:blood; D005449:Fluorenes / Q000652:urine; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009284:Naphthols / Q000652:urine; D011084:Polycyclic Aromatic Hydrocarbons / Q000652:urine*; D011388:Prolactin / Q000097:blood; D011721:Pyrenes / Q000032:analysis; D012016:Reference Values; D013739:Testosterone / Q000097:blood
chemical_list: D005449:Fluorenes; D043373:Follicle Stimulating Hormone, Human; D006728:Hormones; D009284:Naphthols; D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes; C029350:1-naphthol; D013739:Testosterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; C477779:2-hydroxyfluorene; C033146:1-hydroxypyrene; C028405:2-naphthol