title: Cu(II) ion interaction with teicoplanin-vancomycin's analog.
abstract: Teicoplanin, a member of the "last chance" antibiotic family has a similar structure and the same mechanism of action as parent drug vancomycin, which is proved to be an effective binder of Cu(II) ions. However, the potentiometric and spectroscopic studies (UV-visible, CD, NMR) have shown that the modification of the N-terminal structure of the peptide backbone in teicoplanin affects considerably the binding ability towards Cu(II) ions. While vancomycin forms almost instantly the stable 3N complex species involving the N-terminal and two amide nitrogen donors, in case of teicoplanin only two nitrogen donors derived from the N-terminal amino group and adjacent peptide bond are coordinated to Cu(II) ion within the whole pH range studied. The major factor influencing the binding mode is most likely the structure of the N-terminus of the peptide unit in the antibiotic ligand.
authors: Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, 50-383 Wrocław, Poland.
authors: Magdalena
authors: M
authors: Brzezowska
authors: Marzena
authors: M
authors: Kucharczyk-Klamińska
authors: Francesca
authors: F
authors: Bernardi
authors: Daniela
authors: D
authors: Valensin
authors: Nicola
authors: N
authors: Gaggelli
authors: Elena
authors: E
authors: Gaggelli
authors: Gianni
authors: G
authors: Valensin
authors: Małgorzata
authors: M
authors: Jezowska-Bojczuk
mesh_terms: D000192:Actinomycetales / Q000737:chemistry; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D001665:Binding Sites; D002412:Cations / Q000737:chemistry / Q000378:metabolism; D002942:Circular Dichroism; D056831:Coordination Complexes / Q000737:chemistry; D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011199:Potentiometry; D011522:Protons; D013053:Spectrophotometry; D017334:Teicoplanin / Q000737:chemistry* / Q000378:metabolism; D014640:Vancomycin / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D002412:Cations; D056831:Coordination Complexes; D011522:Protons; D017334:Teicoplanin; D014640:Vancomycin; D003300:Copper