title: [The expression and significance of immunity associated genes mRNA in patients with pulmonary embolism].
abstract: OBJECTIVE
  To investigate the molecular alteration of immunity associated genes in patients with pulmonary embolism (PE) so as to preliminarily elucidate its pathogenetic mechanism.
  
  
  METHODS
  Human cDNA microarray analysis was employed in this study, random variance model (RVM) corrected t-test was used for the statistical data analysis of differential gene expression.
  
  
  RESULTS
  In comparison with control, mRNA expression of functional genes of neutrophils, monophagocytes, IFN regulating factors, TNF, adhesion molecules and T cells were significantly different in PE patients. However, gene expressions of B cell immune function and complement activation associated factors were not significantly different between two groups.
  
  
  CONCLUSIONS
  Unbalance expression of immune function associated genes, especially down-regulated expression of T cell mediated function genes, in patients with PE indicates that the etiology of PE might be related to viral infection.
authors: Hospital of Tongji University, Shanghai 200065, China.
authors: Zhu
authors: Z
authors: Gong
authors: Ai-Bin
authors: AB
authors: Liang
authors: Le-Min
authors: LM
authors: Wang
authors: Xiao-Yu
authors: XY
authors: Zhang
authors: Qiang
authors: Q
authors: Wang
authors: Chun-Yu
authors: CY
authors: Huang
authors: Hao-Ming
authors: HM
authors: Song
authors: Hao
authors: H
authors: Wang
authors: Yu-Qin
authors: YQ
authors: Shen
authors: Heng-Jun
authors: HJ
authors: Gao
authors: Xiao-Ying
authors: XY
authors: Shen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015536:Down-Regulation; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007694:Killer Cells, Natural; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D011655:Pulmonary Embolism / Q000235:genetics* / Q000276:immunology*; D012333:RNA, Messenger / Q000235:genetics; D016176:T-Lymphocyte Subsets
chemical_list: D012333:RNA, Messenger