TBP2 is a general transcription factor specialized for female germ cells.
The complexity of the core promoter transcription machinery has emerged as an additional level of transcription regulation that is used during vertebrate development. Recent studies, including one published in BMC Biology, provide mechanistic insights into how the TATA binding protein (TBP) and its vertebrate-specific paralog TBP2 (TRF3) switch function during the transition from the oocyte to the embryo. See research article http://www.biomedcentral.com/1741-7007/7/45.
Müller
Ferenc
F
Department of Medical and Molecular Genetics, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK. f.mueller@bham.ac.uk
Tora
Làszlò
L
D000818:Animals; D005260:Female; D005854:Germ Cells / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D009865:Oocytes / Q000378:metabolism / Q000502:physiology*; D035182:TATA Box Binding Protein-Like Proteins / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
D009687:Nuclear Proteins; D035182:TATA Box Binding Protein-Like Proteins; C480637:TBPL2 protein, human; D014157:Transcription Factors