[Histopathological observation of bone remodeling in rabbit sinusitis model].
OBJECTIVE
To observe the histopathological finding of bone remodeling in rabbit sinusitis model at different time and the tendency, and to discuss the effect of bone in the pathogenesis of sinusitis.


METHODS
First, the rabbit sinusitis model was made, then the experimental animals were divided into 3 groups according to the time of infection. There were 8 rabbits in each experimental group, and 4 rabbits in the control group. The sinus specimen were collected, embedded and stained. The bone in the inoculating side and noninoculating side was scored, and the bone in inoculating side was evaluated quantitatively and semiquantitatively. The parameters included the thickness of mucosa, mucoperiosteum, the density of osteoblast, the amount of osteoclast.


RESULTS
The average bone score in the inoculating side was 2.250, 2.875, 2.875; in the noninoculating side was 1.625, 2.250, 2.500. Between group A and the control group, the difference of all three parameters had statistical significance. Between group B and group A, the difference of the thickness of mucosa and the density of osteoblast had statistical significance. Between group C and group B, none of the three parameters had statistical significance.


CONCLUSIONS
Bacterial sinusitis can lead to bone remodeling, obvious bone destroy can occur at the early phase, then the bone proliferation follows. These results demonstrate that bone remodeling is one of the basic histopathological characters of CRS and might be the reason to lead CRS to a constant and chronic process of inflammation.
Zhang
Jing
J
Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing, China.
Zhou
Bing
B
Zhang
Sheng-Zhong
SZ
Liu
Zhong-Lin
ZL
Li
Shu-Ling
SL
Fan
Er-Zhong
EZ
Cui
Shun-Jiu
SJ
D000818:Animals; D016723:Bone Remodeling; D004195:Disease Models, Animal; D007249:Inflammation; D009295:Nasal Bone / Q000473:pathology; D011817:Rabbits; D012852:Sinusitis / Q000473:pathology*