title: Graph-theoretic characterizations of monotonicity of chemical networks in reaction coordinates.
abstract: This paper derives new results for certain classes of chemical reaction networks, linking structural to dynamical properties. In particular, it investigates their monotonicity and convergence under the assumption that the rates of the reactions are monotone functions of the concentrations of their reactants. This is satisfied for, yet not restricted to, the most common choices of the reaction kinetics such as mass action, Michaelis-Menten and Hill kinetics. The key idea is to find an alternative representation under which the resulting system is monotone. As a simple example, the paper shows that a phosphorylation/dephosphorylation process, which is involved in many signaling cascades, has a global stability property. We also provide a global stability result for a more complicated example that describes a regulatory pathway of a prevalent signal transduction module, the MAPK cascade.
authors: Dipartimento di Sistemi e Informatica, University of Florence, Florence, Italy. angeli@dsi.unifi.it
authors: David
authors: D
authors: Angeli
authors: Patrick
authors: P
authors: De Leenheer
authors: Eduardo
authors: E
authors: Sontag
mesh_terms: D004815:Epidermal Growth Factor / Q000502:physiology; D007700:Kinetics; D020935:MAP Kinase Signaling System / Q000502:physiology*; D008954:Models, Biological; D008956:Models, Chemical; D010766:Phosphorylation / Q000502:physiology
chemical_list: D004815:Epidermal Growth Factor