Oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus, Hong Kong, China.
Resistance to oseltamivir was observed in influenza A pandemic (H1N1) 2009 virus isolated from an untreated person in Hong Kong, China. Investigations showed a resistant virus with the neuraminidase (NA) 274Y genotype in quasi-species from a nasopharyngeal aspirate. Monitoring for the naturally occurring NA 274Y mutation in this virus is necessary.
Chen
Honglin
H
The University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.
Cheung
Chung Lam
CL
Tai
Hung
H
Zhao
Pengxi
P
Chan
Jasper F W
JF
Cheng
Vincent C C
VC
Chan
Kwok Hung
KH
Yuen
Kwok Yung
KY
D000293:Adolescent; D000998:Antiviral Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral; D005260:Female; D006723:Hong Kong; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects*; D009154:Mutation; D009439:Neuraminidase / Q000037:antagonists & inhibitors* / Q000235:genetics; D053139:Oseltamivir / Q000494:pharmacology*
D000998:Antiviral Agents; D053139:Oseltamivir; D009439:Neuraminidase