title: Nardostachys jatamansi protects against cerulein-induced acute pancreatitis.
abstract: OBJECTIVE
  Nardostachys jatamansi belonging to the family Valerianaceae has been used as a remedy for stomach and skin ailments in Korea. The effect of N. jatamansi on acute pancreatitis (AP) has not been defined. Therefore, we investigated the effect of N. jatamansi on cerulein-induced AP.
  
  
  METHODS
  In the pretreatment group, N. jatamansi was administered orally to mice at 10 and 20 mg/kg for 5 days, and the mice were intraperitoneally injected with the stable cholecystokinin analogue cerulein hourly for 6 hours. In the posttreatment group, cerulein was injected hourly for 6 hours, and N. jatamansi was administered at the indicated time (1, 3, and 5 hours after the first cerulein injection) and dose (10 and 20 mg/kg) during the cerulein injection. Blood samples were taken 6 hours later to determine the serum amylase, the lipase, and the cytokine levels. The pancreas and the lung were rapidly removed for morphologic examination, myeloperoxidase assay, and real-time reverse transcription polymerase chain reaction.
  
  
  RESULTS
  Nardostachys jatamansi treatment attenuated the AP, as shown by the histological examination results of the pancreas and the lung, reductions in pancreatic edema, neutrophil infiltration, serum amylase and lipase levels, serum cytokine levels, and messenger RNA expressions of inflammatory mediators.
  
  
  CONCLUSIONS
  These results suggest that N. jatamansi attenuates the severity of AP and pancreatitis-associated lung injury.
authors: Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, South Korea.
authors: Gi-Sang
authors: GS
authors: Bae
authors: Hee-Je
authors: HJ
authors: Park
authors: Do-Yun
authors: DY
authors: Kim
authors: Je-Moon
authors: JM
authors: Song
authors: Tae-Hyeon
authors: TH
authors: Kim
authors: Hyo-Jeong
authors: HJ
authors: Oh
authors: Ki-Jung
authors: KJ
authors: Yun
authors: Rae-Kil
authors: RK
authors: Park
authors: Jung-Ho
authors: JH
authors: Lee
authors: Byung-Cheul
authors: BC
authors: Shin
authors: Hee-Jung
authors: HJ
authors: Sim
authors: Seon-Pyo
authors: SP
authors: Hong
authors: Ho-Joon
authors: HJ
authors: Song
authors: Sung-Joo
authors: SJ
authors: Park
mesh_terms: D000208:Acute Disease; D000681:Amylases / Q000097:blood; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002108:Ceruletide; D016207:Cytokines / Q000097:blood / Q000235:genetics; D004789:Enzyme Activation / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D008049:Lipase / Q000097:blood; D051379:Mice; D008810:Mice, Inbred C57BL; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D032404:Nardostachys / Q000737:chemistry*; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D010195:Pancreatitis / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D009195:Peroxidase / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D016207:Cytokines; D010936:Plant Extracts; D002108:Ceruletide; D009195:Peroxidase; D020928:Mitogen-Activated Protein Kinases; D008049:Lipase; D000681:Amylases