Base pair stacking in nucleosome DNA and bendability sequence pattern.
DNA deformation in the nucleosome involves partial unstacking between bases and base pairs. By adjusting orientations of different base-pair stacks relative to the histone octamer surface, the optimal set of stacks and their positions is derived, resulting in a sequence pattern, theoretically best suitable for nucleosome DNA. The sequence is very much consistent with available experimental data, thus, suggesting a common eukaryotic nucleosome DNA bendability sequence pattern based exclusively on the very basics of DNA.
Trifonov
Edward N
EN
Genome Diversity Center, Institute of Evolution, University of Haifa, Mount Carmel, Haifa 31905, Israel. trifonov@research.haifa.ac.il
D020029:Base Pairing; D004247:DNA / Q000235:genetics*; D009707:Nucleosomes / Q000235:genetics*
D009707:Nucleosomes; D004247:DNA