title: [Retrospective cohort study on the rate of mother-to-child transmission among mothers infected with human immunodeficiency virus type 1 through blood transfusion].
abstract: OBJECTIVE
  To study the rate of mother-to-child transmission (MTCT) on HIV-1.
  
  
  METHODS
  All local residents from 8 townships in a region were screened for mothers who had a history of only one blood transfusion and 63 were found HIV-1 positive. A further study on these HIV-1 positive mothers and their children was conducted with the emphasis on the date of receiving blood transfusion, date and type of nationality, history regarding breastfeeding and so on. Sera specimens from 84 children born from 63 HIV-1 positive mothers were screened, using ELISA for HIV-1 antibody, and positive specimens were confirmed by Western-blot.
  
  
  RESULTS
  The rate of MTCT was 32.1% (27/84) for children with all risk factors related to MTCT. Another 36.8% (7/19) were related to factors on intrauterine, intrapartum and breastfeeding, 35.7% (5/14) to intrapartum and breastfeeding factors, 14.3% (2/14) to intrauterine and intrapartum factors, 37.9% (11/29) to breastfeeding factor alone. By group combination analysis, the MTCT rate was 36.9% (24/65) with breastfeeding, 11.8% (2/17) with artificial feeding, and the former was significantly higher than the latter.
  
  
  CONCLUSIONS
  HIV-1 MTCT rate among mothers caused by a single blood transfusion varied with different risk factors. Breastfeeding played an important role in MTCT, appeared in our study.
authors: Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, China. chensuliang@sina.com
authors: Su-Liang
authors: SL
authors: Chen
authors: Hong-Ru
authors: HR
authors: Zhao
authors: Xiao-Mei
authors: XM
authors: Li
authors: Yu-Qi
authors: YQ
authors: Zhang
authors: Guang-Sheng
authors: GS
authors: Jin
authors: Cui-Ying
authors: CY
authors: Zhao
authors: Yan-Ping
authors: YP
authors: Zhang
authors: Guang-Yi
authors: GY
authors: Bai
authors: Bao-Jun
authors: BJ
authors: Li
authors: Liang
authors: L
authors: Liang
authors: Zhi-Qiang
authors: ZQ
authors: Chen
authors: Yan-Liang
authors: YL
authors: Hui
authors: Fu-Bao
authors: FB
authors: Liu
authors: Zhi-Xian
authors: ZX
authors: Xu
authors: Jian-Guo
authors: JG
authors: Zhu
authors: Yu-Rong
authors: YR
authors: Mao
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D015153:Blotting, Western; D001942:Breast Feeding / Q000009:adverse effects; D002648:Child; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission*; D015528:HIV Seroprevalence; D015497:HIV-1 / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D012189:Retrospective Studies; D012307:Risk Factors; D065227:Transfusion Reaction
chemical_list: D000914:Antibodies, Viral