Enhanced cell permeability of kojic acid-phenylalanine amide with metal complex.
Kojic acid-phenylalanine amide (KA-F-NH(2)), which showed an excellent tyrosinase inhibitory activity, did not inhibit melanogenesis in melanocyte due to its low cell permeability. To enhance its cell permeability by increasing lipophilicity, we prepared metal coordination compounds of KA-F-NH(2) and characterized them by FT-IR and ICP analysis. The metal complex of KA-F-NH(2) inhibited mushroom tyrosinase activity as much as KA-F-NH(2) and reduced melanin contents in melanocyte efficiently.
Kwak
Seon-Yeong
SY
School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea.
Noh
Jin-Mi
JM
Park
So-Hee
SH
Byun
Jang-Woong
JW
Choi
Hye-Ryung
HR
Park
Kyoung-Chan
KC
Lee
Yoon-Sik
YS
D000818:Animals; D045744:Cell Line, Tumor; D002463:Cell Membrane Permeability / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008543:Melanins / Q000378:metabolism; D051379:Mice; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry; D011753:Pyrones / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
D056831:Coordination Complexes; D008543:Melanins; D011753:Pyrones; D010649:Phenylalanine; C020457:phenylalanine amide; C011890:kojic acid; D014442:Monophenol Monooxygenase