Comparison of antimicrobial efficacy of a fixed dose combination of ceftazidime + sulbactam with ceftazidime and sulbactam alone against five bacteria.
The efficacy of the agents was evaluated on the basis of minimum inhibitory concentration (MIC) and time-kill curve analysis in Pseudomonas aeruginosa, Staphylococcus aureus, Acinetobacter baumannii, Mycobacterium smegmatis, and Citrobacter braakii; MIC was found to be 0.5, 4.0, 0.015625, 0.0078125, and 0.0625 mg/L in FDC of ceftazidime + sulbactam, respectively, which is lower than ceftazidime and sulbactam individually. Time-kill curve analysis demonstrated maximum killing of bacteria after 4 h. A fixed dose combination of ceftazidime + sulbactam was found to have stronger antibacterial properties than ceftazidime and sulbactam alone at in vitro analysis.
Shrivastava
S M
SM
Venus Medicine Research Center, Hill Top, Industrial Estate, Jharmajri EPIP, Phase I (Extn) Bhatoli Kalan, Baddi, India. dgmtechnical@venusremedies.com
Shukla
S K
SK
Chaudhary
M
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002442:Ceftazidime / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013407:Sulbactam / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002442:Ceftazidime; D013407:Sulbactam