title: Effect of stimulation on the input parameters of stochastic leaky integrate-and-fire neuronal model.
abstract: The Ornstein-Uhlenbeck neuronal model is specified by two types of parameters. One type corresponds to the properties of the neuronal membrane, whereas the second type (local average rate of the membrane depolarization and its variability) corresponds to the input of the neuron. In this article, we estimate the parameters of the second type from an intracellular record during neuronal firing caused by stimulation (audio signal). We compare the obtained estimates with those from the spontaneous part of the record. As predicted from the model construction, the values of the input parameters are larger for the periods when neuron is stimulated than for the spontaneous ones. Finally, the firing regimen of the model is checked. It is confirmed that the neuron is in the suprathreshold regimen during the stimulation.
authors: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic. lansky@biomed.cas.cz
authors: Petr
authors: P
authors: Lansky
authors: Pavel
authors: P
authors: Sanda
authors: Jufang
authors: J
authors: He
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D004569:Electroencephalography; D006168:Guinea Pigs; D008564:Membrane Potentials / Q000502:physiology; D008959:Models, Neurological; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000145:classification / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D013269:Stochastic Processes; D013997:Time Factors