Pharmacological study on some new 3-[(1-methylpyrrol-2-yl)-methyl]-4-substituted 4,5-dihydro-1H-1,2,4-triazol-5-ones.
3-[(1-Methylpyrrol-2-yl)methyl]-4-substituted 4,5-dihydro-1H-1,2,4-triazol-5-ones were obtained by the cyclization reaction of 1-[(1-methylpyrrol-2-yl)acetyl]-4-substituted semicarbazides in alkaline medium. The effects of the synthesized compounds of the central nervous system of mice were studied.
Pitucha
Monika
M
Department of Organic Chemistry, Medical University, Staszica 6, 20-081 Lublin, Poland. monika.pitucha@am.lublin.pl
Chodkowska
Anna
A
Duda
Renata
R
Jagiełło-Wójtowicz
Ewa
E
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D007103:Immobilization; D008297:Male; D051379:Mice; D011597:Psychomotor Performance / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013874:Thiopental / Q000494:pharmacology; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology*
D000700:Analgesics; D014230:Triazoles; D013874:Thiopental