title: Gliotransmission: Exocytotic release from astrocytes.
abstract: Gliotransmitters are chemicals released from glial cells fulfilling a following set of criteria: (i) they are synthesized by and/or stored in glia; (ii) their regulated release is triggered by physiological and/or pathological stimuli; (iii) they activate rapid (milliseconds to seconds) responses in neighboring cells; and (iv) they play a role in (patho)physiological processes. Astrocytes can release a variety of gliotransmitters into the extracellular space using several different mechanisms. In this review, we focus on exocytotic mechanism(s) underlying the release of three classes of gliotransmitters: (i) amino acids, such as, glutamate and d-serine; (ii) nucleotides, like adenosine 5'-triphosphate; and (iii) peptides, such as, atrial natriuretic peptide and brain-derived neurotrophic factor. It is becoming clear that astrocytes are endowed with elements that qualify them as cells communicating with neurons and other cells within the central nervous system by employing regulated exocytosis.
authors: Department of Neurobiology, Center for Glial Biology in Medicine, Civitan International Research Center, Atomic Force Microscopy & Nanotechnology Laboratories, and Evelyn F. McKnight Brain Institute, University of Alabama, Birmingham, USA. vlad@uab.edu
authors: Vladimir
authors: V
authors: Parpura
authors: Robert
authors: R
authors: Zorec
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D001253:Astrocytes / Q000502:physiology*; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D010455:Peptides / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D000596:Amino Acids; D010455:Peptides; D000255:Adenosine Triphosphate