Plasma PLTP activity is inversely associated with HDL-C levels.
Phospholipid transfer protein (PLTP) is an important modulator of lipoprotein metabolism, including interparticle phospholipid transfer, remodeling of HDL, cholesterol and phospholipid efflux from peripheral tissues, and the production of hepatic VLDL. PLTP also plays an important role in inflammation and oxidative stress. Accordingly, PLTP has been implicated in the development of atherosclerosis. In this study, we evaluated the association between PLTP activity and lipoprotein metabolism in a Chinese patients cohort with or without coronary heart disease (CHD group n = 407, control group n = 215), the PLTP activity was measured and PLTP genotyping was screened for sequence anomalies by PCR. We found that human plasma PLTP activity was negatively associated with plasma HDL and apoA-I levels, and positively associated with plasma TG, apoB and apoE levels. We also found that PLTP rs2294213 polymorphism was tended to be associated with increased plasma PLTP activity.
Chen
Xueying
X
Institute of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, PR China.
Sun
Aijun
A
Institute of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, PR China.
Mansoor
Ather
A
Division of Cardiovascular Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Zou
Yunzeng
Y
Institute of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, PR China.
Ge
Junbo
J
Institute of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, PR China.
Lazar
Jason M
JM
Division of Cardiovascular Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Jiang
Xian-Cheng
XC
Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY, USA.