title: Noninvasive neonatal thymus graft into the axillary cavity extends the lifespan of old mice.
abstract: Neonatal thymus grafts exert a rejuvenating action on various immunological and nonimmunological functions found altered in old mice. Commonly, half of a thymus is grafted under the kidney capsule. The invasiveness of the surgical procedure and the use of limited thymus tissue may explain why precedent survival kinetics remain unaffected. In this trial, we grafted two neonatal thymi into the axillary cavity of old mice, thus reducing the invasiveness of the intervention and increasing the amount of grafted neonatal tissue. Using a Piantanelli parametric model of survivorship, we found a significant change in mortality rate between the two groups (thymus graft and controls).
authors: INRCA, Scientific and Technological Research, Ancona, Italy.
authors: Andrea
authors: A
authors: Basso
authors: Marco
authors: M
authors: Malavolta
authors: Francesco
authors: F
authors: Piacenza
authors: Lory
authors: L
authors: Santarelli
authors: Fiorella
authors: F
authors: Marcellini
authors: Roberta
authors: R
authors: Papa
authors: Eugenio
authors: E
authors: Mocchegiani
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001365:Axilla; D008136:Longevity / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D019060:Minimally Invasive Surgical Procedures / Q000379:methods / Q000662:veterinary; D013534:Survival; D013950:Thymus Gland / Q000254:growth & development / Q000637:transplantation*; D013997:Time Factors; D016042:Transplantation, Heterotopic; D015854:Up-Regulation