title: 2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study.
abstract: For the development of novel antitumor agents, 2,6-dithienyl-4-furyl pyridine derivatives were prepared and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against several human cancer cell lines. Among the 21 prepared compounds, compound 24 exhibited strong topoisomerase I inhibitory activity. In addition, a docking study with topoisomerase I and compound 24 was performed.
authors: College of Pharmacy, Yeungnam University, Kyongsan 712-749, Republic of Korea.
authors: Arjun
authors: A
authors: Basnet
authors: Pritam
authors: P
authors: Thapa
authors: Radha
authors: R
authors: Karki
authors: Hoyoung
authors: H
authors: Choi
authors: Jae Hun
authors: JH
authors: Choi
authors: Minho
authors: M
authors: Yun
authors: Byeong-Seon
authors: BS
authors: Jeong
authors: Yurngdong
authors: Y
authors: Jahng
authors: Younghwa
authors: Y
authors: Na
authors: Won-Jea
authors: WJ
authors: Cho
authors: Youngjoo
authors: Y
authors: Kwon
authors: Chong-Soon
authors: CS
authors: Lee
authors: Eung-Seok
authors: ES
authors: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D001665:Binding Sites; D045744:Cell Line, Tumor; D003198:Computer Simulation; D004264:DNA Topoisomerases, Type I / Q000378:metabolism*; D004250:DNA Topoisomerases, Type II / Q000378:metabolism*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors
chemical_list: D000970:Antineoplastic Agents; D011725:Pyridines; D013876:Thiophenes; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D004264:DNA Topoisomerases, Type I; D004250:DNA Topoisomerases, Type II