[Level of steroid hormones in patients with bronchial asthma combined with hypertension and their dynamics after using antihypertensive medications].
59 patients with bronchial asthma (BA) combined with hypertension have been observed. The authors have studied the level changes of cortisol and sexual hormones. Considerable decrease in level of progesterone and cortisol, and also increase in the level of estradiol have been revealed in the patient's blood. It enhances maintenance and progression of bronchoobstructive a syndrome. The authors have also assessed the dynamics of sexual hormones against antihypertensive therapy of patients with BA. Increase in the level of progesterone against administration of amlodipin has been observed in women and increase in the level of testosterone against administration of of enalapril in men. Obtained data allows to optimize the choice of hypotensive medication in patients with BA combined with hypertension.
Lyzohub
V H
VH
Altunina
N V
NV
D000368:Aged; D017311:Amlodipine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001249:Asthma / Q000097:blood* / Q000150:complications; D004656:Enalapril / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D042341:Gonadal Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D042341:Gonadal Hormones; D017311:Amlodipine; D004656:Enalapril; D006854:Hydrocortisone