[The modulating effect of the horn extract from the saiga of different age on the organothypic lymphoid tissue culture].
The horn extracts from the saiga of different age were used to investigate its effect on organotypic tissue culture of explants from the rat spleen. From 4 to 10 amino acids were detected in the different extract fractions. The horn extracts from the young saiga, at the effective concentration 1 ng/ml, showed stimulating effect in spleen tissue cultures as compared to the control explants. No effect of extracts from the old saiga was observed in tissue culture. Possibly, a stimulation of the cellular proliferation is due to the great amino acid content in saiga horn; however this phenomenon is decreased by the aging.
Chalisova
N I
NI
Romanov
O E
OE
Morozova
P Iu
PIu
Balykina
N A
NA
Lesniak
V V
VV
Sukhonos
Iu A
IuA
Zhekalov
A N
AN
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D006733:Horns / Q000737:chemistry* / Q000254:growth & development; D009924:Organ Culture Techniques; D051381:Rats; D017208:Rats, Wistar; D012418:Ruminants / Q000254:growth & development*; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D014020:Tissue Extracts / Q000302:isolation & purification / Q000494:pharmacology*
D014020:Tissue Extracts