Radionuclide imaging study of long-term pulmonary function after lobectomy in children with congenital cystic lung disease.
OBJECTIVE
We evaluated the long-term pulmonary function after lobectomy for congenital cystic lung disease, in both infants and children, using radionuclide imaging (RI).


METHODS
We performed a retrospective review of 93 patients who underwent resection of cystic lung lesions between 1974 and 2001. The results of postoperative lung volume/perfusion scintigraphy at 1 (n = 64), 5 (n = 32), and 10 years (n = 18) after surgery (V1, 5, 10/Q1, 5, 10) and mean transit time (MTT-a marker for air-trapping) at 1, 5, and 10 years after surgery (MTT1, 5, 10) were compared with respect to age at operation, preoperative infection, underlying disease, and type of surgery.


RESULTS
Patients who were younger than 1 year at the time of surgery showed a significantly lower MTT5 (1.09 +/- 0.08) and MTT10 (1.15 +/- 0.11) than patients who were older than 1 year at the time of surgery (MTT5, 1.49 +/- 0.67; MTT10, 1.54 +/- 0.33). The noninfected group had significantly higher Q10 and lower MTT10 values (P < .05) compared to the infected group. No significant differences were observed between patients with single lobe vs multiple lobe resection.


CONCLUSIONS
The optimal age for surgery in patients with congenital cystic lung disease appears to be less than 1 year.
Komori
Koji
K
Department of Surgery, Tokyo Metropolitan Kiyose Children's Hospital, Kiyose, Tokyo 204-8567, Japan.
Kamagata
Shoichiro
S
Hirobe
Seiichi
S
Toma
Miki
M
Okumura
Kenji
K
Muto
Mitsuru
M
Kasai
Shogo
S
Hayashi
Akira
A
Suenaga
Mayumi
M
Miyakawa
Tomoo
T
D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D015615:Cystic Adenomatoid Malformation of Lung, Congenital / Q000601:surgery; D003560:Cysts / Q000151:congenital* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000002:abnormalities / Q000000981:diagnostic imaging* / Q000601:surgery; D008171:Lung Diseases / Q000151:congenital* / Q000601:surgery*; D008176:Lung Volume Measurements; D008297:Male; D011013:Pneumonectomy / Q000379:methods*; D011877:Radionuclide Imaging; D012129:Respiratory Function Tests / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes