title: A first-generation haplotype map of maize.
abstract: Maize is an important crop species of high genetic diversity. We identified and genotyped several million sequence polymorphisms among 27 diverse maize inbred lines and discovered that the genome was characterized by highly divergent haplotypes and showed 10- to 30-fold variation in recombination rates. Most chromosomes have pericentromeric regions with highly suppressed recombination that appear to have influenced the effectiveness of selection during maize inbred development and may be a major component of heterosis. We found hundreds of selective sweeps and highly differentiated regions that probably contain loci that are key to geographic adaptation. This survey of genetic diversity provides a foundation for uniting breeding efforts across the world and for dissecting complex traits through genome-wide association studies.
authors: United States Department of Agriculture-Agriculture Research Service (USDA-ARS), USA.
authors: Michael A
authors: MA
authors: Gore
authors: Jer-Ming
authors: JM
authors: Chia
authors: Robert J
authors: RJ
authors: Elshire
authors: Qi
authors: Q
authors: Sun
authors: Elhan S
authors: ES
authors: Ersoz
authors: Bonnie L
authors: BL
authors: Hurwitz
authors: Jason A
authors: JA
authors: Peiffer
authors: Michael D
authors: MD
authors: McMullen
authors: George S
authors: GS
authors: Grills
authors: Jeffrey
authors: J
authors: Ross-Ibarra
authors: Doreen H
authors: DH
authors: Ware
authors: Edward S
authors: ES
authors: Buckler
mesh_terms: D001947:Breeding; D002874:Chromosome Mapping; D032461:Chromosomes, Plant / Q000235:genetics; D019143:Evolution, Molecular; D014644:Genetic Variation; D018745:Genome, Plant; D055106:Genome-Wide Association Study; D006239:Haplotypes; D006579:Heterozygote; D006823:Hybrid Vigor; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA; D045868:Sorghum / Q000235:genetics; D003313:Zea mays / Q000235:genetics*