Pollen allergens do not come alone: pollen associated lipid mediators (PALMS) shift the human immune systems towards a T(H)2-dominated response.
Pollen allergy is characterized by a T(H)2-biased immune response to pollen-derived allergens. However, pollen-exposed epithelia do not encounter pure allergen but rather a plethora of protein and non-protein substances. We demonstrated that pollen liberate lipids with chemical and functional similarities to leukotriens and prostaglandins--the pollen associated lipid mediators (PALMs). To date, two main groups of PALMs have been characterized: The immunostimulatory PALMs activating innate immune cells such as neutrophils and eosinophils, and the immunomodulatory E(1)-phytoprostanes blocking IL-12 production of dendritic cells, resulting in the preferential induction of T(H)2 responses. This article reviews our work in the field of PALMs and their effects on cells of the innate and adoptive immune system. From recent results a general picture starts to emerge in which PALMs (and possibly other pollen-associated substances) may--independently from protein allergens--propagate an overall T(H)2 favoring micromilieu in pollen exposed tissue of predisposed individuals.
Gilles
Stefanie
S
ZAUM-Center for Allergy and Environment, Division of Environmental Dermatology, Biedersteiner Str. 29, 80802 Munich, Germany. Stefanie.Gilles@lrz.tum.de
Mariani
Valentina
V
Bryce
Martina
M
Mueller
Martin J
MJ
Ring
Johannes
J
Behrendt
Heidrun
H
Jakob
Thilo
T
Traidl-Hoffmann
Claudia
C