title: Cutaneous pseudallescheria boydii infection in a renal transplant patient: A case report.
abstract: We describe the case of a 59-year-old male renal transplant recipient who presented with a 1 month history of nodular, erythematous, and crusted lesions on the anterior surface of the left leg. There was no history of trauma. The patient had no systemic signs or symptoms. A skin biopsy revealed evidence of a deep fungal infection, with septate and branching hyphae amongst the dermal inflammatory infiltrate, but the culture was negative. Initial treatment with itraconazole proved ineffective and new lesions appeared. New tissue samples were obtained for culture, allowing the isolation of Pseudallescheria boydii. The patient underwent surgical excision of the lesions combined with voriconazole 400 mg/day for 2 months. After this period no new lesions appeared and the patient has remained without recurrence after 2 years of follow-up. Pseudallescheria boydii is an opportunistic fungus that can cause systemic infection mainly in immunocompromised patients that manifests as pulmonary, osteoarticular, ocular, vascular, cutaneous or central nervous system disease. Resistance to therapy can occur with infection progression and high mortality. Treatment with the combination of an antifungal agent, mainly voriconazole, and surgery, when feasible, probably provide the best results in cutaneous infections.
authors: Serviço de Dermatologia, Hospitais da Universidade de Coimbra, Coimbra, Portugal. ze_carlos_cardoso@yahoo.com.br
authors: José Carlos
authors: JC
authors: Cardoso
authors: David
authors: D
authors: Serra
authors: Raquel
authors: R
authors: Cardoso
authors: José Pedro
authors: JP
authors: Reis
authors: Oscar
authors: O
authors: Tellechea
authors: Américo
authors: A
authors: Figueiredo
mesh_terms: D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D008271:Mycetoma / Q000209:etiology*; D011541:Pseudallescheria