[Choice of statistical approaches and analysis of blood serum proteome profiles in an experiment with 24-hour head-down tilt (-15 degrees)].
Variability analysis of normal human proteoma requires a valid and crisp algorithm for mass-spectrometry data analysis. The goal was to test methods of statistical analysis of blood serum proteoma profiles in an experiment with 24-hr. HDT using the small sample nonparametric criteria. The investigation revealed peaks that appear to be a molecular response of organism to simulated microgravity. Further identification of fiducially mobile peaks with the help of tandem mass-spectrometry will enable disclosure of subtle mechanisms of adaptation to the spaceflight factors and improvement of human health evaluation in space missions of varying length.
Pakharukova
N A
NA
Nosovskiĭ
A M
AM
Pastushkova
L Kh
LKh
Trifonova
O P
OP
Larina
I M
IM
D000222:Adaptation, Physiological; D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D002940:Circadian Rhythm / Q000502:physiology*; D005500:Follow-Up Studies; D018475:Head-Down Tilt / Q000502:physiology*; D006801:Humans; D015233:Models, Statistical; D020543:Proteome / Q000502:physiology*; D044967:Serum / Q000502:physiology*; D055815:Young Adult
D001798:Blood Proteins; D020543:Proteome