Differentiation of two distinct clusters among currently circulating influenza A(H1N1)v viruses, March-September 2009.
Analysis of all complete genome sequences of the pandemic influenza A(H1N1)v virus available as of 10 September 2009 revealed that two closely related but distinct clusters were circulating in most of the affected countries at the same time. The characteristic differences are located in genes encoding the two surface proteins - haemagglutinin and neuraminidase - and four internal proteins - the polymerase PB2 subunit, nucleoprotein, matrix protein M1 and the non-structural protein NS1. Phylogenetic inference was demonstrated by neighbour joining, maximum likelihood and Bayesian trees analyses of the involved genes and by tree construction of concatenated sequences.
Fereidouni
S R
SR
Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany. sasan.fereidouni@fli.bund.de
Beer
M
M
Vahlenkamp
T
T
Starick
E
E
D001499:Bayes Theorem; D004196:Disease Outbreaks; D005060:Europe / Q000453:epidemiology; D016679:Genome, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D007251:Influenza, Human / Q000453:epidemiology / Q000821:virology*; D016013:Likelihood Functions; D008800:Mexico / Q000453:epidemiology; D009439:Neuraminidase / Q000235:genetics; D019590:Nucleocapsid Proteins; D010802:Phylogeny; D016601:RNA-Binding Proteins / Q000235:genetics; D012324:RNA-Dependent RNA Polymerase / Q000235:genetics; D012621:Seasons; D017385:Sequence Homology; D014481:United States / Q000453:epidemiology; D014758:Viral Core Proteins / Q000235:genetics; D014763:Viral Matrix Proteins / Q000235:genetics; D017361:Viral Nonstructural Proteins / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics
D019267:Hemagglutinin Glycoproteins, Influenza Virus; C085820:INS1 protein, influenza virus; C488936:M1 protein, Influenza A virus; C048842:NP protein, Influenza A virus; D019590:Nucleocapsid Proteins; C057027:PB2 protein, Influenzavirus A; D016601:RNA-Binding Proteins; D014758:Viral Core Proteins; D014763:Viral Matrix Proteins; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; C483468:hemagglutinin, human influenza A virus; D012324:RNA-Dependent RNA Polymerase; D009439:Neuraminidase