Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes.
The effects of Brazilian green propolis ethanol extract on Cry j1-induced cys-leukotrienes and histamine release from peripheral leukocytes of patients with allergic rhinitis were investigated. One of the key mechanisms for the anti-allergic properties of the extract was revealed to be the suppression of cys-LTs release. Furthermore, a series of propolis components and their phenethyl esters were synthesized and evaluated as inhibitors of cys-LTs release. Artepillin C, baccharin, and kaempferide were the major active components of the ethanol extract. The inhibitory activity of artepillin C phenethyl ester was comparable to that of existing LT synthesis inhibitors.
Tani
Hiroko
H
Institute for Bee Products and Health Science, Yamada Apiculture Center, Inc, 194 Ichiba, Kagamino 708-0393, Japan. ht0807@yamada-bee.com
Hasumi
Keiko
K
Tatefuji
Tomoki
T
Hashimoto
Ken
K
Koshino
Hiroyuki
H
Takahashi
Shunya
S
D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001516:Bees / Q000737:chemistry; D045744:Cell Line, Tumor; D003545:Cysteine / Q000276:immunology*; D006632:Histamine / Q000276:immunology; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology; D015289:Leukotrienes / Q000276:immunology*; D011429:Propolis / Q000737:chemistry* / Q000494:pharmacology*; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*
D018926:Anti-Allergic Agents; D015289:Leukotrienes; C112381:cysteinyl-leukotriene; D006632:Histamine; D011429:Propolis; D003545:Cysteine