title: Tissue-mediated control of immunopathology in coeliac disease.
abstract: Coeliac disease is an inflammatory disorder with autoimmune features that is characterized by destruction of the intestinal epithelium and remodelling of the intestinal mucosa following the ingestion of dietary gluten. A common feature of coeliac disease and many organ-specific autoimmune diseases is a central role for T cells in causing tissue destruction. In this Review, we discuss the emerging hypothesis that, in coeliac disease, intestinal tissue inflammation--induced either by infectious agents or by gluten--is crucial for activating T cells and eliciting their tissue-destructive effector functions.
authors: Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA. bjabri@bsd.uchicago.edu
authors: Bana
authors: B
authors: Jabri
authors: Ludvig M
authors: LM
authors: Sollid
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D002446:Celiac Disease / Q000235:genetics / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D005983:Glutens / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D005983:Glutens