title: Telomerase gene mutation screening in Chinese patients with aplastic anemia.
abstract: To study the incidence of telomerase gene mutations in Chinese patients with acquired bone marrow failure (BMF) and explore its relationship with telomere shortening. Blood samples from 66 patients with aplastic anemia (AA) in northern China were collected and TERC mutation analysis was performed. Two TERC mutations were identified. The incidence of telomerase gene mutations in Chinese people with acquired AA is similar to that of the western people.
authors: Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, No. 1, Shuai Fuyuan, Dongcheng District, Beijing 100730, China. hanbing_li@sina.com.cn
authors: Bing
authors: B
authors: Han
authors: Bo
authors: B
authors: Liu
authors: Wei
authors: W
authors: Cui
authors: Xuan
authors: X
authors: Wang
authors: Jie
authors: J
authors: Lin
authors: Yongqiang
authors: Y
authors: Zhao
mesh_terms: D000741:Anemia, Aplastic / Q000201:enzymology / Q000235:genetics*; D001855:Bone Marrow Diseases; D002681:China / Q000453:epidemiology; D004252:DNA Mutational Analysis; D005787:Gene Frequency; D006801:Humans; D015994:Incidence; D009154:Mutation; D019098:Telomerase / Q000235:genetics*; D016615:Telomere / Q000648:ultrastructure
chemical_list: C509186:TERT protein, human; D019098:Telomerase