title: Detection of a new yellow fever virus lineage within the South American genotype I in Brazil.
abstract: Nucleotide sequences of two regions of the genomes of 11 yellow fever virus (YFV) samples isolated from monkeys or humans with symptomatic yellow fever (YF) in Brazil in 2000, 2004, and 2008 were determined with the objective of establishing the genotypes and studying the genetic variation. Results of the Bayesian phylogenetic analysis showed that sequences generated from strains from 2004 and 2008 formed a new subclade within the clade 1 of the South American genotype I. The new subgroup is here designated as 1E. Sequences of YFV strains recovered in 2000 belong to the subclade 1D, which comprises previously characterized YFV strains from Brazil. Molecular dating analyses suggested that the new subclade 1E started diversifying from 1D about 1975 and that the most recent 2004-2008 isolates arose about 1985.
authors: Serviço de Virologia do Instituto Adolfo Lutz, São Paulo, SP, Brazil.
authors: Renato P
authors: RP
authors: de Souza
authors: Peter G
authors: PG
authors: Foster
authors: Maria Anice M
authors: MA
authors: Sallum
authors: Terezinha L M
authors: TL
authors: Coimbra
authors: Adriana Y
authors: AY
authors: Maeda
authors: Vivian R
authors: VR
authors: Silveira
authors: Eduardo S
authors: ES
authors: Moreno
authors: Fernanda G
authors: FG
authors: da Silva
authors: Iray M
authors: IM
authors: Rocco
authors: Ivani B
authors: IB
authors: Ferreira
authors: Akemi
authors: A
authors: Suzuki
authors: Fabíola M
authors: FM
authors: Oshiro
authors: Selma M C N
authors: SM
authors: Petrella
authors: Luiz E
authors: LE
authors: Pereira
authors: Giselda
authors: G
authors: Katz
authors: Cilea H
authors: CH
authors: Tengan
authors: Melissa M
authors: MM
authors: Siciliano
authors: Cecília L S
authors: CL
authors: Dos Santos
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000818:Animals; D001499:Bayes Theorem; D001938:Brazil / Q000453:epidemiology; D019143:Evolution, Molecular; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D008992:Monkey Diseases / Q000453:epidemiology* / Q000821:virology; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D013020:South America; D014759:Viral Envelope Proteins; D015004:Yellow Fever / Q000453:epidemiology* / Q000662:veterinary / Q000821:virology; D015005:Yellow fever virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification
chemical_list: D020413:3' Untranslated Regions; D014759:Viral Envelope Proteins; C074932:prM protein, Flavivirus