title: A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotein 2.
abstract: Advanced stage papillary serous tumors of the ovary are responsible for the majority of ovarian cancer deaths, yet the molecular determinants modulating patient survival are poorly characterized. Here, we identify and validate a prognostic gene expression signature correlating with survival in a series of microdissected serous ovarian tumors. Independent evaluation confirmed the association of a prognostic gene microfibril-associated glycoprotein 2 (MAGP2) with poor prognosis, whereas in vitro mechanistic analyses demonstrated its ability to prolong tumor cell survival and stimulate endothelial cell motility and survival via the alpha(V)beta(3) integrin receptor. Increased MAGP2 expression correlated with microvessel density suggesting a proangiogenic role in vivo. Thus, MAGP2 may serve as a survival-associated target.
authors: Department of Gynecologic Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
authors: Samuel C
authors: SC
authors: Mok
authors: Tomas
authors: T
authors: Bonome
authors: Vinod
authors: V
authors: Vathipadiekal
authors: Aaron
authors: A
authors: Bell
authors: Michael E
authors: ME
authors: Johnson
authors: Kwong-kwok
authors: KK
authors: Wong
authors: Dong-Choon
authors: DC
authors: Park
authors: Ke
authors: K
authors: Hao
authors: Daniel K P
authors: DK
authors: Yip
authors: Howard
authors: H
authors: Donninger
authors: Laurent
authors: L
authors: Ozbun
authors: Goli
authors: G
authors: Samimi
authors: John
authors: J
authors: Brady
authors: Mike
authors: M
authors: Randonovich
authors: Cindy A
authors: CA
authors: Pise-Masison
authors: J Carl
authors: JC
authors: Barrett
authors: Wing H
authors: WH
authors: Wong
authors: William R
authors: WR
authors: Welch
authors: Ross S
authors: RS
authors: Berkowitz
authors: Michael J
authors: MJ
authors: Birrer
mesh_terms: D002448:Cell Adhesion; D002465:Cell Movement; D003285:Contractile Proteins / Q000235:genetics*; D005260:Female; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D009361:Neoplasm Invasiveness; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D011994:Recombinant Proteins / Q000235:genetics; D015398:Signal Transduction; D016019:Survival Analysis
chemical_list: D003285:Contractile Proteins; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; C115627:MFAP5 protein, human; D011994:Recombinant Proteins