Pyridyl-substituted corrole isomers: synthesis and their regulation to G-quadruplex structures.
G-quadruplex DNA plays an important role in the potential therapeutic target for the design and development of anticancer drugs. As various G-quadruplex sequences in the promoter regions or telomeres can form different secondary structural modes and display a diversity of biology functions, variant G-quadruplex interactive agents may be necessary to cure different disease by differentiating variant types of G-quadruplexes. We synthesize five cationic methylpyridylium corroles and compare the interactions of corroles with different types of G-quadruplexes such as cmyc, htelo, and bcl2 by using surface plasmon resonance. Because of the importance of human telomere G-quadruplex DNA, we focus on the biological properties of the interactions between human telomere G-quadruplex DNA and corrole isomers using CD, T(m), PCR-stop (PCR= polymerase chain reaction), and polymerase-stop assay, which demonstrate the excellent ability of the corrole to induce and stabilize the G-quadruplex. This study provides the first experimental insight into how selectivity might be achieved for different G-quadruplexes by a single group of methylpyridylium corrole isomers that may be optimized for potential selective cancer therapy.
Ma
Heng
H
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P.R. China.
Zhang
Ming
M
Zhang
Dan
D
Huang
Rong
R
Zhao
Yang
Y
Yang
Hao
H
Liu
Yijing
Y
Weng
Xiaocheng
X
Zhou
Yangyang
Y
Deng
Minggang
M
Xu
Liang
L
Zhou
Xiang
X
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002942:Circular Dichroism; D054856:G-Quadruplexes; D007536:Isomerism; D007700:Kinetics; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*; D020349:Surface Plasmon Resonance; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000378:metabolism; D044366:Transition Temperature
D000970:Antineoplastic Agents; D011166:Porphyrins; D011725:Pyridines; C431863:corrole; D019098:Telomerase; C023666:pyridine