title: [Histopathological observation of bone remodeling in rabbit sinusitis model].
abstract: OBJECTIVE
  To observe the histopathological finding of bone remodeling in rabbit sinusitis model at different time and the tendency, and to discuss the effect of bone in the pathogenesis of sinusitis.
  
  
  METHODS
  First, the rabbit sinusitis model was made, then the experimental animals were divided into 3 groups according to the time of infection. There were 8 rabbits in each experimental group, and 4 rabbits in the control group. The sinus specimen were collected, embedded and stained. The bone in the inoculating side and noninoculating side was scored, and the bone in inoculating side was evaluated quantitatively and semiquantitatively. The parameters included the thickness of mucosa, mucoperiosteum, the density of osteoblast, the amount of osteoclast.
  
  
  RESULTS
  The average bone score in the inoculating side was 2.250, 2.875, 2.875; in the noninoculating side was 1.625, 2.250, 2.500. Between group A and the control group, the difference of all three parameters had statistical significance. Between group B and group A, the difference of the thickness of mucosa and the density of osteoblast had statistical significance. Between group C and group B, none of the three parameters had statistical significance.
  
  
  CONCLUSIONS
  Bacterial sinusitis can lead to bone remodeling, obvious bone destroy can occur at the early phase, then the bone proliferation follows. These results demonstrate that bone remodeling is one of the basic histopathological characters of CRS and might be the reason to lead CRS to a constant and chronic process of inflammation.
authors: Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing, China.
authors: Jing
authors: J
authors: Zhang
authors: Bing
authors: B
authors: Zhou
authors: Sheng-Zhong
authors: SZ
authors: Zhang
authors: Zhong-Lin
authors: ZL
authors: Liu
authors: Shu-Ling
authors: SL
authors: Li
authors: Er-Zhong
authors: EZ
authors: Fan
authors: Shun-Jiu
authors: SJ
authors: Cui
mesh_terms: D000818:Animals; D016723:Bone Remodeling; D004195:Disease Models, Animal; D007249:Inflammation; D009295:Nasal Bone / Q000473:pathology; D011817:Rabbits; D012852:Sinusitis / Q000473:pathology*