[Models and methods of evaluation of geroprotective activity of pharmacological drugs].
Current approaches to evaluation of efficacy and safety of potential life span extending drugs (geroprotectors) are reviewed in the paper. The methods and protocol of evaluating the effect of pharmacological drugs on aging and life span in mice which have used by the authors are described in details. Principles and criteria of evaluation of degree of evidence the experimental studies in rodents as well as a possibility of extrapolation to humans are discussed.
Anisimov
V N
VN
Zabezhinskiĭ
M A
MA
Popovich
I G
IG
D000375:Aging / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D008136:Longevity / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D023421:Models, Animal; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*
D004364:Pharmaceutical Preparations