title: [A histopathological study: chronic rhinosinusitis in adolescents versus adults].
abstract: OBJECTIVE
  To conduct a histopathology study of adolescents with chronic rhinosinusitis (CRS) to compare the sinus mucosa with adult CRS and to explore their different pathological characteristics and lesion patterns.
  
  
  METHODS
  Twenty cases of adolescents (median age: 14 years; range: 11-16 years) and 16 cases of adult CRS (median age: 36 years; range: 21-56 years) were performed functional endoscopy operation despite conventional medical therapy, histopathology of uncinate process mucosa were analyzed for inflammatory cell and morphologic studies. Archival tissue from adolescents and adults with CRS were stained with HE, AB-PAS (alcian blue-periodic acid-schiff) as well as Van Gieson. Statistical analysis t-test was performed using SPSS.
  
  
  RESULTS
  Adolescents CRS sinus mucosa, as compared with adult CRS control, had a higher density of submucosal lymphocytes (t = 2.09, P = 0.04), higher density of submucosal plasma cell (t = 2.46, P = 0.02), lower density of submucosal eosinophils (t = -3.72, P = 0.01), thinner basement membranes and more intact epithelium (t = -2.50, P = 0.02 and t = 5.63, P = 0.00 respectively) and fewer submucosal mucous glands (t = -2.13, P = 0.04). There were significant differences between two groups.
  
  
  CONCLUSIONS
  Lymphocytes were the predominant inflammatory cell type in the sinus mucosa of adolescents with CRS. But it has less eosinophilic inflammation, more plasma cell infiltration, basement membrane thickening, and mucus gland hyperplasia in characteristic adult CRS. Differences between adolescents and adult CRS suggest differing pathogenic mechanisms or progression in the inflammatory response with a protracted disease.
authors: Department of Otorhinolaryngology, Head & Neck Surgery, Beijing Tongren Hospital Affiliated to Capital University of Medical Sciences, Key Laboratory Otolaryngology, Head & Neck Surgery, Beijing 100730, China.
authors: Hong-Rui
authors: HR
authors: Zang
authors: Tong
authors: T
authors: Wang
authors: Yun-Chuan
authors: YC
authors: Li
authors: Pu
authors: P
authors: Li
authors: Sheng-Zhong
authors: SZ
authors: Zhang
authors: Er-Zhong
authors: EZ
authors: Fan
authors: Ying
authors: Y
authors: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002908:Chronic Disease; D004804:Eosinophils / Q000378:metabolism; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000473:pathology*; D012852:Sinusitis / Q000378:metabolism* / Q000473:pathology*; D055815:Young Adult