title: Bone mineral and body composition alterations in paediatric cystic fibrosis patients.
abstract: BACKGROUND
  With the increased life span of cystic fibrosis (CF) patients, CF-related bone diseases could have an increased prevalence and morbidity in this group. In children, previous retrospective and prospective studies have yielded conflicting results on bone mineralization.
  
  
  OBJECTIVE
  To monitor body composition and bone mineral status of children with CF.
  
  
  METHODS
  We reviewed the dual-energy X-ray absorptiometry (DXA) data of 161 children with CF (age 10 +/- 4.8 years). Total body bone mineral content (BMCt), total lean tissue mass (LTMt) and total fat mass (FMt) were measured and compared to expected data calculated from ideal weight for height (Wi; e.g. BMCti, LTMti, FMti). The bt (BMCt/BMCti), lt (LTMt/LTMti) and ft (FMt/FMti) ratios were used as quantitative variables.
  
  
  RESULTS
  Low bt ratio was found at all ages (mean bt ratio 0.94 +/- 0.10; P < 0.001), even in children <6 years of age. However, the children's BMCt was satisfactorily adapted to their weight. lt and ft ratios were not constant across age groups. Children <10 years had 8% reduction of their lt ratio, maintaining normal levels thereafter. The opposite trend was found for ft ratio. Poor clinical, nutritional status and vitamin A levels were correlated with bt and lt ratios.
  
  
  CONCLUSIONS
  Our results indicate that children with CF could have early alterations in their bone status and that lt and ft ratios did not have constant values across ages. Interpreting DXA data using this approach is suitable in children with CF.
authors: Service de Pédiatrie, Pneumologie, Allergologie, Mucoviscidose, Hôpital Femme Mère Enfant, 59 boulevard Pinel, Bron cedex, France. philippe.reix@chu-lyon.fr
authors: Philippe
authors: P
authors: Reix
authors: Gabriel
authors: G
authors: Bellon
authors: Pierre
authors: P
authors: Braillon
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D001823:Body Composition; D015519:Bone Density; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity