Properties of anti-washout-type calcium silicate bone cements containing gelatin.
Novel washout-resistant bone substitute materials consisting of gelatin-containing calcium silicate cements (CSCs) were developed. The washout resistance, setting time, diametral tensile strength (DTS), morphology, and phase composition of the hybrid cements were evaluated. The results indicated that the dominant phase of beta-Ca(2)SiO(4) for the SiO(2)-CaO powders increased with an increase in the CaO content of the sols. After mixing with water, the setting times of the CSCs ranged from 10 to 29 min, increasing with a decrease in the amount of CaO in the sols. Addition of gelatin into the CSC significantly prolonged (P < 0.05) the setting time by about 2 and 8 times, respectively, for 5% and 10% gelatin. However, the presence of gelatin appreciably improved the anti-washout and brittle properties of the cements without adversely affecting mechanical strength. It was concluded that 5% gelatin-containing CSC may be useful as bioactive bone repair materials.
Chen
Chun-Cheng
CC
Department of Dentistry, Chung-Shan Medical University Hospital, Taichung, Taiwan, Republic of China.
Lai
Meng-Heng
MH
Wang
Wei-Chung
WC
Ding
Shinn-Jyh
SJ
D001843:Bone Cements / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018786:Bone Substitutes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017610:Calcium Compounds / Q000737:chemistry*; D002484:Cementation; D019245:Compressive Strength / Q000187:drug effects; D005780:Gelatin / Q000737:chemistry* / Q000494:pharmacology; D006244:Hardness / Q000187:drug effects*; D008422:Materials Testing; D011208:Powders; D012823:Silicate Cement / Q000737:chemistry / Q000494:pharmacology; D017640:Silicates / Q000737:chemistry*; D013314:Stress, Mechanical; D013499:Surface Properties; D013718:Tensile Strength / Q000187:drug effects; D014867:Water / Q000494:pharmacology*; D014961:X-Ray Diffraction
D001843:Bone Cements; D018786:Bone Substitutes; D017610:Calcium Compounds; D011208:Powders; D017640:Silicates; D014867:Water; D012823:Silicate Cement; D005780:Gelatin; C031293:calcium silicate