Aliphatic hyperbranched polyester: a new building block in the construction of multifunctional nanoparticles and nanocomposites.
Herein we report the design and synthesis of multifunctional hyperbranched polyester-based nanoparticles and nanocomposites with properties ranging from magnetic, fluorescence, antioxidant and X-ray contrast. The fabrication of these nanostructures was achieved using a novel aliphatic and biodegradable hyperbranched polyester (HBPE) synthesized from readily available diethyl malonate. The polymer's globular structure with functional surface carboxylic groups and hydrophobic cavities residing in the polymer's interior allows for the formation of multifunctional polymeric nanoparticles, which are able to encapsulate a diversity of hydrophobic cargos. Via simple surface chemistry modifications, the surface carboxylic acid groups were modified to yield nanoparticles with a variety of surface functionalizations, such as amino, azide and propargyl groups, which mediated the conjugation of small molecules. This capability achieved the engineering of the HBPE nanoparticle surface for specific cell internalization studies and the formation of nanoparticle assemblies for the creation of novel nanocomposites that retained, and in some cases enhanced, the properties of the parental nanoparticle building blocks. Considering these results, the HBPE polymer, nanoparticles and composites should be ideal for biomedical, pharmaceutical, nanophotonics applications.
Santra
Santimukul
S
Nanoscience Technology Center, College of Medicine, University of Central Florida, 12424 Research Parkway, Orlando, Florida 32826, USA.
Kaittanis
Charalambos
C
Perez
J Manuel
JM
D000818:Animals; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005434:Flow Cytometry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018613:Microscopy, Confocal; D008962:Models, Theoretical; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared
D011091:Polyesters; D017239:Paclitaxel