An atypical peripheral nerve sheath tumour with pseudoglandular architecture in a dog.
This case describes a subcutaneous soft tissue tumour in a German Shepherd dog. Histologically, the lesion was characterized by proliferating ovoid cells, loosely arranged in a collagenous to myxoid stroma, and by numerous pseudoglandular structures lined by neoplastic cells. Immunohistochemically, neoplastic cells were labelled with vimentin, glial fibrillary acidic protein and S100 antibodies, but not with cytokeratin, desmin and smooth muscle actin antibodies. Ultrastructurally, neoplastic cells were characterized by numerous mitochondria surrounded by endoplasmic reticulum and contained few secondary lysosomes. This tumour was diagnosed as a subcutaneous peripheral nerve sheath tumour (PNST) with pseudoglandular architecture. This case illustrates the morphological diversity of PNST and provides new insight into the differential diagnosis of cutaneous tumours of similar morphology in the dog.
Volmer
Christelle
C
Department of Pathology, National Veterinary School of Alfort, 7 avenue du Général de Gaulle, 94704 Maisons-Alfort Cedex, France. c.volmer@hotmail.fr
Caplier
Laura
L
Reyes-Gomez
Edouard
E
Huet
Hélène
H
Owen
Roger A
RA
Fontaine
Jean-Jacques
JJ
D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D046529:Microscopy, Electron, Transmission / Q000662:veterinary; D018317:Nerve Sheath Neoplasms / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*