title: [Liquid-based cytology for esophageal carcinoma screening].
abstract: OBJECTIVE
  Cytologic screening of asymptomatic high risk individuals can detect curable esophageal carcinomas and has been used for several decades. However, the sensitivity of such screening is relatively low, which limits its wide use and development. This study was to investigate the utility of liquid-based cytology in esophageal carcinoma screening.
  
  
  METHODS
  A mass screening of esophageal carcinoma was performed for asymptomatic residents in Yaocun County, Linzhou City, Henan Province, China. Esophageal biopsy samples were put into a liquid buffer for cytologic diagnosis and subsequent endoscopic biopsies were made on all subjects. Cytologic categories were adapted from criteria of the Bethesda system (TBS). RESULTS of liquid-based cytology were compared with those from endoscopic biopsy. The sensitivity and the specificity of liquid-based cytology were evaluated.
  
  
  RESULTS
  Carcinomas in situ and carcinomas were identified in 17 (2.4%) of 710 subjects. Measured by ASC/AGC (atypical squamous cells or atypical glandular cells) as the detection threshold, the sensitivity and the specificity of liquid-based cytology were 76.5% and 76.0%, respectively.
  
  
  CONCLUSIONS
  In a hospital with a high level of conventional cytology, liquid-based technique can be used widely since the work load of reading slides may greatly decrease, although this technique do not significantly improve the sensitivity of screening.
authors: Department of Pathology, Cancer Hospital (Institute), Chinese Academy of Medical Sciences, Beijing, 100021, P. R. China.
authors: Hui-Qin
authors: HQ
authors: Guo
authors: Wen-Qiang
authors: WQ
authors: Wei
authors: Ning
authors: N
authors: Lu
authors: Jian
authors: J
authors: Cao
authors: Zhong-Lin
authors: ZL
authors: Li
authors: Nai-Peng
authors: NP
authors: Wang
authors: Guo-Qing
authors: GQ
authors: Wang
authors: Qin-Jing
authors: QJ
authors: Pan
authors: You-Lin
authors: YL
authors: Qiao
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000175:diagnosis*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D002681:China; D003581:Cytodiagnosis / Q000379:methods*; D004938:Esophageal Neoplasms / Q000175:diagnosis*; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis; D012680:Sensitivity and Specificity