Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity.
Despite a safe and effective vaccine, endemic rubella remains a problem in developing countries. Isolated cases and outbreaks can occur in areas with high vaccine coverage. Individuals, especially pregnant women who remain unimmunized or do not seroconvert, are susceptible to infection and their infants are at risk for congenital rubella syndrome (CRS). Both humoral and cellular immune responses contribute to immune protection. Classically, immunity to rubella has been assessed through the detection of rubella-specific antibody titers. In this study we examined correlates of both humoral and cellular immunity in a large population of immunized young adults in Olmsted County, MN. We were unable to find any significant correlation between cytokine production after in-vitro rubella stimulation and serum antibody titers.
Tosh
Pritish K
PK
Mayo Vaccine Research Group, Mayo Clinic , Rochester, Minnesota 55905, USA.
Kennedy
Richard B
RB
Vierkant
Robert A
RA
Jacobson
Robert M
RM
Poland
Gregory A
GA
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D002478:Cells, Cultured / Q000276:immunology / Q000378:metabolism / Q000821:virology; D002648:Child; D016207:Cytokines / Q000096:biosynthesis / Q000097:blood*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007156:Immunologic Memory; D007371:Interferon-gamma / Q000096:biosynthesis / Q000097:blood; D015850:Interleukin-6 / Q000096:biosynthesis / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000276:immunology*; D008910:Minnesota; D012412:Rubella virus / Q000276:immunology*; D012494:Sampling Studies; D014611:Vaccination; D055815:Young Adult
D000914:Antibodies, Viral; D016207:Cytokines; C508600:IL6 protein, human; D015850:Interleukin-6; D022542:Measles-Mumps-Rubella Vaccine; D007371:Interferon-gamma