title: Risk of spontaneous miscarriage in euthyroid women with thyroid autoimmunity undergoing IVF: a meta-analysis.
abstract: OBJECTIVE
  To investigate whether thyroid autoimmunity (TAI) is associated with increased risk for spontaneous miscarriage in subfertile, euthyroid women undergoing IVF.
  
  
  METHODS
  Meta-analysis of observational studies.
  
  
  METHODS
  Four prospective studies that reported data on 1098 subfertile women undergoing IVF (141 with TAI and 957 controls) were included in the meta-analysis.
  
  
  METHODS
  Miscarriage risk ratio (RR).
  
  
  METHODS
  Clinical pregnancy rate and delivery rate.
  
  
  RESULTS
  Euthyroid, subfertile women with TAI undergoing IVF demonstrated significantly higher risk for miscarriage compared with controls (four studies-fixed effects RR: 1.99, 95% confidence interval: 1.42- 2.79, P<0.001). No significant difference in clinical pregnancy and delivery rates was detected between groups.
  
  
  CONCLUSIONS
  Based on the currently available evidence, it appears that the presence of TAI is associated with an increased risk for spontaneous miscarriage in subfertile women achieving a pregnancy through an IVF procedure.
authors: Unit of Reproductive Endocrinology Unit for Human Reproduction, First Department of Obstetrics and Gynecology, Medical School, Papageorgiou General Hospital, Aristotle University, Ring Road, Nea Efkarpia, 56403 Thessaloniki, Greece. toulis@endo.gr
authors: Konstantinos A
authors: KA
authors: Toulis
authors: Dimitrios G
authors: DG
authors: Goulis
authors: Christos A
authors: CA
authors: Venetis
authors: Efstratios M
authors: EM
authors: Kolibianakis
authors: Roberto
authors: R
authors: Negro
authors: Basil C
authors: BC
authors: Tarlatzis
authors: Ioannis
authors: I
authors: Papadimas
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood / Q000209:etiology* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D013961:Thyroid Gland / Q000276:immunology*
chemical_list: D001323:Autoantibodies