title: Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers.
abstract: Epidemiological studies have suggested an inverse correlation between red wine consumption and the incidence of CVD. However, Champagne wine has not been fully investigated for its cardioprotective potential. In order to assess whether acute and moderate Champagne wine consumption is capable of modulating vascular function, we performed a randomised, placebo-controlled, cross-over intervention trial. We show that consumption of Champagne wine, but not a control matched for alcohol, carbohydrate and fruit-derived acid content, induced an acute change in endothelium-independent vasodilatation at 4 and 8 h post-consumption. Although both Champagne wine and the control also induced an increase in endothelium-dependent vascular reactivity at 4 h, there was no significant difference between the vascular effects induced by Champagne or the control at any time point. These effects were accompanied by an acute decrease in the concentration of matrix metalloproteinase (MMP-9), a significant decrease in plasma levels of oxidising species and an increase in urinary excretion of a number of phenolic metabolites. In particular, the mean total excretion of hippuric acid, protocatechuic acid and isoferulic acid were all significantly greater following the Champagne wine intervention compared with the control intervention. Our data suggest that a daily moderate consumption of Champagne wine may improve vascular performance via the delivery of phenolic constituents capable of improving NO bioavailability and reducing matrix metalloproteinase activity.
authors: Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK.
authors: David
authors: D
authors: Vauzour
authors: Emily J
authors: EJ
authors: Houseman
authors: Trevor W
authors: TW
authors: George
authors: Giulia
authors: G
authors: Corona
authors: Roselyne
authors: R
authors: Garnotel
authors: Kim G
authors: KG
authors: Jackson
authors: Christelle
authors: C
authors: Sellier
authors: Philippe
authors: P
authors: Gillery
authors: Orla B
authors: OB
authors: Kennedy
authors: Julie A
authors: JA
authors: Lovegrove
authors: Jeremy P E
authors: JP
authors: Spencer
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D018592:Cross-Over Studies; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005419:Flavonoids / Q000494:pharmacology; D006801:Humans; D007478:Iontophoresis; D017078:Laser-Doppler Flowmetry; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D016877:Oxidants / Q000097:blood; D010636:Phenols / Q000494:pharmacology / Q000652:urine; D059808:Polyphenols; D016037:Single-Blind Method; D019714:Tissue Inhibitor of Metalloproteinases / Q000097:blood; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014920:Wine; D055815:Young Adult
chemical_list: D005419:Flavonoids; D016877:Oxidants; D010636:Phenols; D059808:Polyphenols; D019714:Tissue Inhibitor of Metalloproteinases; D020780:Matrix Metalloproteinase 9