Two new isopimarane diterpenes from the feces of Trogopterus xanthipes.
Chemical investigation of Trogopterus Feces has led to the isolation of two new isopimarane diterpenes, wulingzhic acid A (1) and wulingzhic acid B (2). Their structures were elucidated by chemical and extensive spectral analysis. Compounds 1 and 2 exhibited weak activity of antithrombin and moderate activity of antiplatelet aggregation in vitro.
Yang
Nian-Yun
NY
Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Traditional Chinese Medicine, Nanjing, China.
Tao
Wei-Wei
WW
Zhu
Min
M
Duan
Jin-Ao
JA
Jiang
Jian-Guo
JG
D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000991:Antithrombins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005243:Feces / Q000737:chemistry*; D008516:Medicine, Chinese Traditional; D010974:Platelet Aggregation / Q000187:drug effects*; D012589:Sciuridae
D000925:Anticoagulants; D000991:Antithrombins; D004224:Diterpenes; C554151:wulingzhic acid A; C554152:wulingzhic acid B