Epidemiology of bloodstream infections in patients with haematological malignancies with and without neutropenia.
All bacterial isolates from 7058 patients admitted to haemato-oncology wards at National Taiwan University Hospital between 2002 and 2006 were characterized. In total 1307 non-duplicate bloodstream isolates were made from all patients with haematological malignancy; 853 (65%) of these were from neutropenic patients. Gram-negative bacteria predominated (60%) in neutropenic isolates with Escherichia coli (12%), Klebsiella pneumoniae (10%), Acinetobacter calcoaceticus-baumannii complex (6%), and Stenotrophomonas maltophilia (6%) the most frequent. Coagulase-negative staphylococci (19%) and Staphylococcus aureus (4%) were the most common Gram-positive pathogens. Resistance to ciprofloxacin was found in 50% of E. coli and 20% of K. pneumoniae isolates from neutropenic patients. Extensively drug-resistant A. calcoaceticus-baumannii complex and vancomycin-resistant enterococci were also found during the study period. Emerging antimicrobial resistant pathogens are an increasing threat to neutropenic cancer patients.
Chen
C-Y
CY
Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Tsay
W
W
Tang
J-L
JL
Tien
H-F
HF
Chen
Y-C
YC
Chang
S-C
SC
Hsueh
P-R
PR
D000151:Acinetobacter Infections / Q000453:epidemiology; D040981:Acinetobacter baumannii / Q000302:isolation & purification; D016470:Bacteremia / Q000150:complications / Q000453:epidemiology* / Q000382:microbiology; D004927:Escherichia coli Infections / Q000453:epidemiology; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology; D019337:Hematologic Neoplasms / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007710:Klebsiella Infections / Q000453:epidemiology; D007711:Klebsiella pneumoniae / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D009503:Neutropenia / Q000150:complications* / Q000453:epidemiology; D013203:Staphylococcal Infections / Q000453:epidemiology; D020615:Stenotrophomonas maltophilia / Q000302:isolation & purification; D013624:Taiwan / Q000453:epidemiology