title: In situ follicular lymphoma associated with progressive transformation of germinal centers.
abstract: The authors report here a case of in situ follicular lymphoma (FL) associated with progressive transformation of the germinal center (PTGC). A 39-year-old Japanese male developed a mass in the right cervical region. Biopsy of the enlarged lymph node led to a diagnosis of PTGC. Then, 5 years later, the lymphadenopathy recurred. The second biopsy specimens contained numerous germinal centers, including PTGC. Although most follicles were cytologically reactive, a few GCs appeared to be somewhat monotonous, composed predominantly of centrocytes and lacking mitotic figures and tangible body macrophages. Immunohistochemical studies demonstrated that these atypical GCs were CD10+, CD20+, and bcl-2+, with λ-light-chain restriction. A previous report emphasized the differential diagnostic problem between PTGC and the floral variant of FL. However, the present case indicated that in situ FL should be added to the list of differential diagnoses for PTGC.
authors: Dokkyo Medical University School of Medicine, Mibu, Japan. t-handa@dokkyomed.ac.jp
authors: Tomoyuki
authors: T
authors: Handa
authors: Kazuhiro
authors: K
authors: Maki
authors: Asuki
authors: A
authors: Segawa
authors: Nobuhide
authors: N
authors: Masawa
authors: Kinuko
authors: K
authors: Mitani
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D018858:Germinal Center / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007142:Immunoglobulin gamma-Chains / Q000235:genetics / Q000378:metabolism; D008224:Lymphoma, Follicular / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009333:Neck; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; D007142:Immunoglobulin gamma-Chains; D019253:Proto-Oncogene Proteins c-bcl-2