Missense mutation of Abcg5 in stroke-prone spontaneously hypertensive rats does not influence lymphatic sitosterol absorption regardless of the dose: comparison with Wistar rats.
The lymphatic recovery of radiolabeled sitosterol administered in various amounts to the stomach was almost the same between stroke-prone spontaneously hypertensive rats (SHRSPs), a strain having a missense mutation in ATP binding cassette transporter g5 (Abcg5), and Wistar rats, a normal strain. The results suggest that the mutation of Abcg5 in SHRSPs, compared with Wistar rats, did not influence the ability for intestinal sitosterol absorption regardless of the dose.
Hamada
Tadateru
T
Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan.
Kodama
Yoko
Y
Imaizumi
Katsumi
K
Ikeda
Ikuo
I
D000071018:ATP Binding Cassette Transporter, Subfamily G, Member 5; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000042:Absorption; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000378:metabolism; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism*; D008074:Lipoproteins / Q000235:genetics*; D008208:Lymphatic System / Q000378:metabolism*; D008297:Male; D020125:Mutation, Missense; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D012855:Sitosterols / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D020521:Stroke
D000071018:ATP Binding Cassette Transporter, Subfamily G, Member 5; D018528:ATP-Binding Cassette Transporters; C480692:Abcg5 protein, rat; D008074:Lipoproteins; D012855:Sitosterols; C025473:gamma-sitosterol