title: Metabolic syndrome components in patients with autosomal-dominant polycystic kidney disease.
abstract: BACKGROUND
  The aim of this work was to compare the prevalence of the metabolic syndrome (MS) and its components between a group of autosomal-dominant polycystic kidney disease (ADPKD) patients with normal kidney function and no prior diagnosis of diabetes and healthy controls.
  
  
  METHODS
  Forty-nine patients with ADPKD (age 35.9 +/- 11.1 years) with serum creatinine <1.35 mg/dl and 50 healthy controls (36.7 +/- 9.2 years) were enrolled for the study. Physical examination, basic laboratory measurements and oral glucose tolerance test were performed in all subjects.
  
  
  RESULTS
  In the group of ADPKD patients, when compared to controls, the following values were significantly higher: waist-to-hip ratio (0.84 +/- 0.09 vs. 0.81 +/- 0.10, p = 0.046), systolic blood pressure (133.9 +/- 19.8 vs. 122.2 +/- 14.9 mm Hg, p = 0.0023), diastolic blood pressure (92.9 +/- 12.4 vs. 82.9 +/- 9.3 mm Hg, p < 0.0001), fasting glycemia (91.6 +/- 10.5 vs. 84.5 +/- 9.2 mg/dl, p = 0.04), and HbA(1C) (5.41 +/- 0.35 vs. 5.28 +/- 0.33%, p = 0.06, borderline significance). Adult Treatment Panel III criteria of MS were fulfilled by 14% of patients and 14% of controls, while International Diabetes Federation criteria were fulfilled by 22% of patients and 20% of controls, without any significant difference between the groups.
  
  
  CONCLUSIONS
  The presence of ADPKD with normal kidney function is associated with components of MS such as hypertension, abdominal obesity and higher fasting glycemia.
authors: Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland. mariola.nowacka@o2.pl
authors: Maria
authors: M
authors: Pietrzak-Nowacka
authors: Krzysztof
authors: K
authors: Safranow
authors: Elzbieta
authors: E
authors: Byra
authors: Agnieszka
authors: A
authors: Bińczak-Kuleta
authors: Andrzej
authors: A
authors: Ciechanowicz
authors: Kazimierz
authors: K
authors: Ciechanowski
mesh_terms: D000328:Adult; D000886:Anthropometry; D001786:Blood Glucose / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D001823:Body Composition / Q000502:physiology; D048909:Diabetes Complications / Q000453:epidemiology / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000378:metabolism*; D016891:Polycystic Kidney, Autosomal Dominant / Q000453:epidemiology / Q000378:metabolism*; D051437:Renal Insufficiency / Q000453:epidemiology / Q000378:metabolism; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin