Can focused US with a diagnostic US contrast agent favorably affect renal function?
Focused ultrasonography (US) with simultaneous administration of a US microbubble contrast agent was used to transiently increase the glomerular filtration rate while altering the sieving properties of glomeruli in normal rabbits. In its current form, this process has very limited application potential to states of abnormal renal function.
Sica
Domenic A
DA
Division of Nephrology, Virginia Commonwealth University Health System, Box 980160, MCV Station, Richmond, VA 23298-0160, USA. dsica@mcvh-vcu.edu
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003404:Creatinine / Q000652:urine; D003911:Dextrans / Q000652:urine; D005466:Fluorocarbons / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000528:radiation effects*; D007668:Kidney / Q000187:drug effects / Q000528:radiation effects*; D007674:Kidney Diseases / Q000000981:diagnostic imaging*; D045423:Microbubbles; D011817:Rabbits; D014465:Ultrasonics; D014463:Ultrasonography; D014554:Urination
D003287:Contrast Media; D003911:Dextrans; D005466:Fluorocarbons; D003404:Creatinine; C042852:perflutren