title: [Optimized clinical use of vancomycin, a prospective observational study in a Paris teaching hospital].
abstract: BACKGROUND
  Vancomycin is still the cornerstone of antibiotic therapy for patients with suspected or proven invasive methicillin resistant Staphylococcus aureus infections. However, clinical and pharmacodynamic studies underline that appropriate doses depend on the infection site, the patient's weight, his renal function, and the bacterial susceptibility.
  
  
  OBJECTIVE
  In this prospective study made in a Paris teaching hospital, our two goals were to describe the modalities of infusion and serum concentration obtained during therapy, in our pediatrics and adults population.
  
  
  RESULTS
  In our hospital, vancomycin was administered every eight hours in 83 % (97/102) of the cases and the doses used were 30 mg/kg per day in 67 % of cases (68/102). Serum trough levels reached 15 mcg/ml and 20 mcg/ml in 36 % and 18 % of cases respectively. Moreover, despite adequate doses, trough levels of 15 mcg/ml were obtained in only 40 % of cases.
  
  
  CONCLUSIONS
  Vancomycin infusion use could be optimized, by defining optimal serum concentrations and monitoring made by a mobile team of infectious diseases specialists.
authors: Service de microbiologie - hygiène hospitalière, université Paris Descartes, CHU Necker-Enfants-Malades, AP-HP, France; Université Paris Descartes, CHU Necker-Enfants-Malades, AP-HP, équipe mobile d'infectiologie, France.
authors: F
authors: F
authors: Taieb
authors: A
authors: A
authors: Le Monnier
authors: E
authors: E
authors: Bille
authors: F
authors: F
authors: Lanternier
authors: F
authors: F
authors: Mechai
authors: F
authors: F
authors: Ribadeau-Dumas
authors: E
authors: E
authors: Maenulein
authors: C
authors: C
authors: Forge
authors: O
authors: O
authors: Corriol
authors: X
authors: X
authors: Nassif
authors: O
authors: O
authors: Lortholary
authors: J-R
authors: JR
authors: Zahar
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D006784:Hospitals, Teaching; D006801:Humans; D010297:Paris; D011446:Prospective Studies; D014640:Vancomycin / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin