Vigabatrin: a comprehensive review of drug properties including clinical updates following recent FDA approval.
BACKGROUND
Vigabatrin (Sabril) was approved in the USA in mid-2009 for the adjunctive treatment of refractory complex partial seizures and as treatment of infantile spasms. Vigabatrin's more than 30-year history of research and development is condensed into a clinically relevant review pertaining to this 2009 approval.
A review of the scientific literature was conducted with special focus given to the drug molecule, its mechanism of action, its effects on living systems (e.g., pharmacokinetic, pharmacologic and toxicologic), and its anticipated role among antiepileptic drugs in the USA.


CONCLUSIONS
The recent approval of vigabatrin makes a significant addition to antiepileptic drug options. The FDA implemented a Risk Evaluation and Mitigation Strategy to control for the possibility of severe adverse drug events.
Tolman
Justin A
JA
Creighton University School of Pharmacy and Health Professions, Omaha, NE 68178, USA. justintolman@creighton.edu
Faulkner
Michele A
MA
D000328:Adult; D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D017277:Drug Approval; D017029:Epilepsy, Complex Partial / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008875:Middle Aged; D012042:Registries; D013036:Spasms, Infantile / Q000188:drug therapy; D014481:United States; D020888:Vigabatrin / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D014786:Vision Disorders / Q000139:chemically induced; D055815:Young Adult
D000927:Anticonvulsants; D020888:Vigabatrin