Novel neofusapyrones isolated from Verticillium dahliae as potent antifungal substances.
Novel fusapyrone analogs, deoxyneofusapyrone and 7-desmethyldeoxyneofusapyrone were isolated from a pathogenic fungus, Verticillium dahliae, which causes Verticillium wilt disease in Helianthus annuus. Spectral analyses revealed that these are 2-pyrone type analogs of deoxyfusapyrone and its 7-desmethyl derivative, respectively. Biological assay disclosed that 10microg of deoxyneofusapyrone inhibited the growth of MRSA clinical isolate 87-7927.
Honma
Miho
M
Faculty of Agriculture and Life Science, Hirosaki University, 3 Bunkyo-Cho, Hirosaki, Aomori 036-8561, Japan.
Kudo
Shinji
S
Takada
Noboru
N
Tanaka
Kazuaki
K
Miura
Tomisato
T
Hashimoto
Masaru
M
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008956:Models, Chemical; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D020172:Verticillium / Q000737:chemistry*
C548718:7-desmethyldeoxyneofusapyrone; D000935:Antifungal Agents; D005960:Glucosides; D011753:Pyrones; C548717:deoxyneofusapyrone; C088397:fusapyrone