title: Indian hedgehog, a neglected member of hedgehog pathway, may offer a novel avenue for colorectal cancer therapy.
abstract: Published data on hedgehog (Hh) pathway activation in colorectal cancer (CRC) are conflicting, and the effect of the Hh pathway inhibitor on the viability of colon cancer cells is controversial. This article focuses attention on the often-neglected, yet likely, critical role of Indian Hh in the course of colonic tumor progression and hypothesizes that upregulation of Indian Hh expression may offer a novel therapeutic approach against CRC through inducing differentiation of tumor cells and through abrogating the Sonic Hh signaling that drives CRC growth.
authors: Department of Gastroenterology, The People's Hospital of Deyang City, Deyang, Sichuan, China.
authors: Xiangsheng
authors: X
authors: Fu
authors: Xiatong
authors: X
authors: Yang
authors: Luping
authors: L
authors: Zhao
mesh_terms: D000236:Adenoma / Q000235:genetics / Q000473:pathology; D002454:Cell Differentiation; D003106:Colon / Q000502:physiology; D003110:Colonic Neoplasms / Q000235:genetics / Q000473:pathology; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015536:Down-Regulation; D005786:Gene Expression Regulation; D053823:Hedgehog Proteins / Q000235:genetics / Q000627:therapeutic use*; D006801:Humans; D010641:Phenotype; D015854:Up-Regulation
chemical_list: D053823:Hedgehog Proteins