[Concentration of serum leptin and age in Chinese women and comparison with other races].
OBJECTIVE
To determine the relationship between concentration of serum leptin and age in females, and to establish the reference value and compare it with other races.


METHODS
Serum leptin concentration of 690 adult healthy women (aged 20 approximately 81 years) was measured with ELISA.


RESULTS
The serum leptin concentration increased with age (r=0.224, P<0.001), and cubic regression was the best-fitting model. Leptin concentration had significant positive correlation with weight (r=0.574) and body mass index (r=0.618). The geometric mean of leptin concentration in normal weight, overweight and obesity was (8.94+/-1.82), (17.6+/-1.89), and (34.7+/-1.69) microg/L, respectively, with significant difference among the 3 groups (P<0.001). Leptin in pre-menopause, peri-menopause and post-menopause women was (9.68+/-1.81), (11.7+/-1.89), and (11.4+/-2.21) microg/L, respectively. The reference value of serum leptin in normal weight females was 5.30 approximately 12.6 microg/L. The curve-fitting of leptin with age in this group was significantly lower than American non Hispanic White (NHW), non Hispanic Black (NHB), and American Mexican (AM) females.


CONCLUSIONS
This study provides reliable reference value of serum leptin in adult women and discovers ethnic difference with American NHW, NHB, and AM females.
Zhang
Rong
R
Institute of Endocrinology and Metabolism, Central South University, Changsha 410011, China.
Liao
Eryuan
E
Wu
Xianping
X
Xie
Hui
H
Shan
Pengfei
P
Zhang
Hong
H
Luo
Xianghang
X
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002681:China / Q000208:ethnology; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D012016:Reference Values; D044465:White People; D055815:Young Adult
D020738:Leptin