title: Multivalent supramolecular dendrimer-based drugs.
abstract: Supramolecular complexes consisting of a hydrophobic dendrimer host [DAB-dendr-(NHCONH-Ad)(64)] as well as solubilizing and bioactive guest molecules have been synthesized using a noncovalent approach. The guest-host supramolecular assembly is first preassembled in chloroform and transferred via the neat phase to aqueous solution. The bioactive guest molecules can bind to a natural (serotonin 5-HT(3)) receptor with nanomolar affinity as well as to the synthetic dendrimer receptor in aqueous solution, going toward a dynamic multivalent supramolecular construct capable of adapting itself to a multimeric receptor motif.
authors: Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Universitàà di Siena, Via A. Moro, 53100 Siena, Italy.
authors: Simone
authors: S
authors: Galeazzi
authors: Thomas M
authors: TM
authors: Hermans
authors: Marco
authors: M
authors: Paolino
authors: Maurizio
authors: M
authors: Anzini
authors: Laura
authors: L
authors: Mennuni
authors: Antonio
authors: A
authors: Giordani
authors: Gianfranco
authors: G
authors: Caselli
authors: Francesco
authors: F
authors: Makovec
authors: E W
authors: EW
authors: Meijer
authors: Salvatore
authors: S
authors: Vomero
authors: Andrea
authors: A
authors: Cappelli
mesh_terms: D050091:Dendrimers / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D044406:Receptors, Serotonin, 5-HT3 / Q000378:metabolism*; D014867:Water / Q000737:chemistry* / Q000378:metabolism
chemical_list: D050091:Dendrimers; D044406:Receptors, Serotonin, 5-HT3; D014867:Water