[Update of asthenospermia-related genes and proteins].
One of the most common causes of male infertility is asthenospermia, whose pathogenesis, however, is not yet clear. Recent researches have found that some genes (such as tektin-2, DNAI1, DNAH5, DNAH11, AKAP4, SEPT4 and Smcp) and proteins (such as sperm proteins ACTB, ANXA5, PRM1, PRM2 and SABP and seminal proteins Tf, PSA, PAP and Fractalkine) are associated with asthenospermia. The finding of these molecular markers has provided a base for the explanation of the molecular mechanism of asthenospermia, and these markers may become the diagnostic and therapeutic targets of the disease.
Zhou
Qi-zhao
QZ
Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China. zhou1224@fimmu.com
Feng
Chun-qiong
CQ
Mao
Xiang-ming
XM
D054758:A Kinase Anchor Proteins / Q000235:genetics; D000818:Animals; D053627:Asthenozoospermia / Q000235:genetics* / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000235:genetics; D019175:DNA Methylation / Q000235:genetics; D020558:GTP Phosphohydrolases / Q000235:genetics; D006801:Humans; D008297:Male; D009154:Mutation; D058112:Septins
D054758:A Kinase Anchor Proteins; C485480:AKAP4 protein, human; D003598:Cytoskeletal Proteins; D020558:GTP Phosphohydrolases; C492027:SEPTIN4 protein, human; D058112:Septins