title: Production of a new type of amidepsine with a sugar moiety by static fermentation of Humicola sp. FO-2942.
abstract: Static fermentation of amidepsine-producing fungus Humicola sp. FO-2942 led to the production of six new amidepsines, including a new type of glycosylated congener. Non-glycosylated amidepsine J inhibited both human diacylglycerol acyltransferases 1 (DGAT1) and DGAT2 with the same IC(50) value of 40 muM, whereas glycosylated amidepsines F to I showed very weak inhibitory activity against DGAT1 and DGAT2.
authors: Graduate School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
authors: Junji
authors: J
authors: Inokoshi
authors: Yoichi
authors: Y
authors: Takagi
authors: Ryuji
authors: R
authors: Uchida
authors: Rokuro
authors: R
authors: Masuma
authors: Satoshi
authors: S
authors: Omura
authors: Hiroshi
authors: H
authors: Tomoda
mesh_terms: D001203:Ascomycota / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D051048:Diacylglycerol O-Acyltransferase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D005285:Fermentation; D006801:Humans; D062385:Hydroxybenzoates / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure
chemical_list: D004791:Enzyme Inhibitors; D062385:Hydroxybenzoates; D051048:Diacylglycerol O-Acyltransferase