Modafinil effects on cognitive function in HIV+ patients treated for fatigue: a placebo controlled study.
Both mild cognitive impairment and fatigue are common among people with HIV/AIDS. This study examined the efficacy of modafinil for HIV+ patients who sought treatment for fatigue in a placebo-controlled double-blind 4-week trial. A battery of standard neuropsychological tests was administered at study entry and Week 4, and change in performance was compared for 59 patients receiving modafinil versus 44 patients receiving placebo. A significant effect on fatigue was observed. In addition, cognitive performance, as measured by a global change score, improved more in the modafinil than in the placebo group although the effect was not specific to any cognitive domain.
McElhiney
Martin
M
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA. mcelhin@pi.cpmc.columbia.edu
Rabkin
Judith
J
Van Gorp
Wilfred
W
Rabkin
Richard
R
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D015704:CD4 Antigens / Q000378:metabolism; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology*; D004311:Double-Blind Method; D005221:Fatigue / Q000150:complications / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D000077408:Modafinil; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D012328:RNA Viruses; D012720:Severity of Illness Index; D019562:Viral Load / Q000379:methods; D055815:Young Adult
D001559:Benzhydryl Compounds; D015704:CD4 Antigens; D000697:Central Nervous System Stimulants; D000077408:Modafinil