title: [Amplification effects in nerve regeneration after different segment injury: experiment with rabbit median nerve].
abstract: OBJECTIVE
  To investigate the impact of different section injury on the median nerve during peripheral nerve regeneration.
  
  
  METHODS
  18 New-Zealand rabbits were divided into 3 groups. We took the proximal, intermediate and distal nerve segment as donor nerve, the restore ratio of the number of donator fibers to recipient fibers is 1:4. We took the corresponding right side nerve as control, the restore ratio of the number of donator fibers to recipient fibers is 1:1. We then observed the general condition of regenerated nerve, counted the number of regenerated fibers, measured its conduction of velocity and wet weights of musculus flexor digitorum sublimis 3 months after operation.
  
  
  RESULTS
  The numbers of recipient fiber of 3 different groups were as follows: group I: 1747 +/- 375, group I: 1785 +/- 442, group III: 1863 +/- 321; Control goup I: 2234 +/- 364, control group II: 2319 +/- 237, control group III: 2346 +/- 308. The results of conduction of velocity were: group I: 19.5 m/s, group II: 19.9 m/s, group III: 21.3 m/s; Control group I: 57.1 +/- 3.7 m/s, control group I: 56.4 +/- 2.5 m/s, control group III: 56.8 +/- 2.3 m/s. The results of wet weights of musculus flexor digitorum sublines were as follows: group I: 1.7247 +/- 0.0891 g, group II:1.7239 +/- 0.0903 g, group III: 1.7253 +/- 0.0798 g. Control group I: 2.0448 +/- 0.1013 g, control group II: 2.0433 +/- 0.0861 g, control group III: 2.0456 +/- 0.0947 g.
  
  
  CONCLUSIONS
  The amplification phenomenon exist in every group, the amplified ratio augment according to the distance of the site from neuron, but the conduction of velocity is decreased gradually . The wet weights of musculus flexor digitorum sublines has no significant difference between 3 groups.
authors: Department of Orthopedic Trauma, People's Hospital, Peking University, Beijing, China.
authors: Yan-hua
authors: YH
authors: Wang
authors: Dian-ying
authors: DY
authors: Zhang
authors: Pei-xun
authors: PX
authors: Zhang
authors: Xiao-feng
authors: XF
authors: Yin
authors: Yu-hu
authors: YH
authors: Kou
authors: Jing
authors: J
authors: Wang
authors: Kai
authors: K
authors: Yu
authors: Xuan
authors: X
authors: Li
authors: Hong-bo
authors: HB
authors: Zhang
authors: Bao-guo
authors: BG
authors: Jiang
mesh_terms: D000818:Animals; D008297:Male; D008475:Median Nerve / Q000293:injuries* / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D011817:Rabbits