title: Low-frequency BOLD fluctuations demonstrate altered thalamocortical connectivity in diabetic neuropathic pain.
abstract: BACKGROUND
  In this paper we explored thalamocortical functional connectivity in a group of eight patients suffering from peripheral neuropathic pain (diabetic pain), and compared it with that of a group of healthy subjects. We hypothesized that functional interconnections between the thalamus and cortex can be altered after years of ongoing chronic neuropathic pain.
  
  
  RESULTS
  Functional connectivity was studied through a resting state functional magnetic resonance imaging (fMRI) paradigm: temporal correlations between predefined regions of interest (primary somatosensory cortex, ventral posterior lateral thalamic nucleus, medial dorsal thalamic nucleus) and the rest of the brain were systematically investigated. The patient group showed decreased resting state functional connectivity between the thalamus and the cortex.
  
  
  CONCLUSIONS
  This supports the idea that chronic pain can alter thalamocortical connections causing a disruption of thalamic feedback, and the view of chronic pain as a thalamocortical dysrhythmia.
authors: CCS fMRI, Koelliker Hospital, Corso Galileo Ferraris, Turin, Italy. franco.cauda@unito.it
authors: Franco
authors: F
authors: Cauda
authors: Katiuscia
authors: K
authors: Sacco
authors: Federico
authors: F
authors: D'Agata
authors: Sergio
authors: S
authors: Duca
authors: Dario
authors: D
authors: Cocito
authors: Giuliano
authors: G
authors: Geminiani
authors: Filippo
authors: F
authors: Migliorati
authors: Gianluca
authors: G
authors: Isoardo
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology; D009434:Neural Pathways / Q000503:physiopathology; D010146:Pain / Q000503:physiopathology*; D011795:Surveys and Questionnaires; D013788:Thalamus / Q000503:physiopathology*