title: Molecular characteristics of occult hepatitis B virus from blood donors in southeast China.
abstract: The characteristics of 30 carriers with occult hepatitis B virus (HBV) infection (OBI) were compared with those of 30 individuals diagnosed as being HBV carriers at the time of blood donation, 60 asymptomatic carriers, and 60 chronic hepatitis patients. The prevalence of genotype C was significantly higher in carriers with OBIs than in any other HBsAg-positive (HBsAg(+)) group (P < 0.001). Specific amino acid substitutions in the regions from amino acids 117 to 121 and amino acids 144 to 147 located in the major hydrophilic region of the S gene were associated with carriers with OBIs (P < 0.01 for carriers with OBIs versus HBsAg(+) donors, carriers with OBIs versus HBsAg(+) asymptomatic carriers, and carriers with OBIs versus HBsAg(+) chronic hepatitis patients). G145R was the major variation in the HBV isolates responsible for local occult HBV infections.
authors: National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Science, Xiamen University, Xiamen, Fujian Province, China.
authors: Quan
authors: Q
authors: Yuan
authors: Shan-Hai
authors: SH
authors: Ou
authors: Chang-Rong
authors: CR
authors: Chen
authors: Sheng-Xiang
authors: SX
authors: Ge
authors: Bin
authors: B
authors: Pei
authors: Qing-Rui
authors: QR
authors: Chen
authors: Qiang
authors: Q
authors: Yan
authors: Yong-Cai
authors: YC
authors: Lin
authors: Hong-Ying
authors: HY
authors: Ni
authors: Cheng-Hao
authors: CH
authors: Huang
authors: Anthony E T
authors: AE
authors: Yeo
authors: James W K
authors: JW
authors: Shih
authors: Jun
authors: J
authors: Zhang
authors: Ning-Shao
authors: NS
authors: Xia
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D001782:Blood Donors; D002353:Carrier State / Q000821:virology*; D002681:China; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000821:virology*; D006514:Hepatitis B Surface Antigens / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics* / Q000302:isolation & purification*; D019694:Hepatitis B, Chronic / Q000821:virology; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens