title: Response of coronary heart disease risk factors to changes in body fat during diet-induced weight reduction in Japanese obese men: A pilot study.
abstract: OBJECTIVE
  Serial measurements were used to examine the response of coronary heart disease (CHD) risk factors to regional fat changes during weight reduction.
  
  
  METHODS
  Nine Japanese obese men participated in a diet-induced weight loss program. Regional fat masses, abdominal visceral fat area (VFA), subcutaneous fat area (SFA) and CHD risk factors, including total (TC), high (HDLC)- and low-density lipoprotein cholesterol (LDLC), triglycerides (TG), fasting plasma glucose, immunoreactive insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and glycosylated hemoglobin A(1c) (HbA(1c)) were assessed at baseline and after 1, 2 and 3 months.
  
  
  RESULTS
  Meanweight reduction during the study was -11.9 +/- 4.2 kg, which was associated with a gradual, significant decrease (p < 0.05) in arm, leg and trunk fat masses, VFA and SFA. The levels of TC, LDLC and TG decreased significantly within 1 month and remained at these values, whereas HDLC, HOMA-IR, and HbA(1c) did not change. There was no significant correlation between changes in regional fat masses and CHD risk factors in any period studied.
  
  
  CONCLUSIONS
  CHD risk factors do not necessarily respond in the same manner as changes in body fat during diet-induced moderate weight reduction.
authors: National Institute of Health and Nutrition, Tokyo, Japan. ohkawara@nih.go.jp
authors: Kazunori
authors: K
authors: Ohkawara
authors: Yoshio
authors: Y
authors: Nakata
authors: Shigeharu
authors: S
authors: Numao
authors: Hiroyuki
authors: H
authors: Sasai
authors: Yasutomi
authors: Y
authors: Katayama
authors: Tomoaki
authors: T
authors: Matsuo
authors: Tomohiro
authors: T
authors: Okura
authors: Kiyoji
authors: K
authors: Tanaka
mesh_terms: D000328:Adult; D000886:Anthropometry; D050218:Body Fat Distribution; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D002149:Energy Intake; D015444:Exercise; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology / Q000628:therapy*; D012307:Risk Factors; D050151:Subcutaneous Fat / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
chemical_list: D002784:Cholesterol; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D014280:Triglycerides