title: Current status of radioactive seed for localization of non palpable breast lesions.
abstract: BACKGROUND
  Wire-localized breast biopsy (WLBB) remains the standard method for the surgical excision of nonpalpable breast lesions. Because of many of its shortcomings, most important a high microscopic positive margin rate, alternative approaches have been described, including radioactive seed localization (RSL). This review highlights the literature regarding RSL, including safety, the ease of the procedure, billing, and oncologic outcomes.
  
  
  METHODS
  Medline and PubMed were searched using the terms "radioactive seed" and "breast." All peer-reviewed studies were included in this review.
  
  
  CONCLUSIONS
  RSL is a promising approach for the resection of nonpalpable breast lesions. It is a reliable and safe alternative to WLBB. RSL is at least equivalent compared with WLBB in terms of the ease of the procedure, removing the target lesion, the volume of breast tissue excised, obtaining negative margins, avoiding a second operative intervention, and allowing for simultaneous axillary staging.
authors: Department of Surgery, Mayo Clinic, Rochester, MN, USA. jakub.james@mayo.edu
authors: James W
authors: JW
authors: Jakub
authors: Richard J
authors: RJ
authors: Gray
authors: Amy C
authors: AC
authors: Degnim
authors: Judy C
authors: JC
authors: Boughey
authors: Mary
authors: M
authors: Gardner
authors: Charles E
authors: CE
authors: Cox
mesh_terms: D001365:Axilla; D001706:Biopsy / Q000191:economics / Q000379:methods*; D001941:Breast Diseases / Q000000981:diagnostic imaging; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000191:economics / Q000473:pathology / Q000601:surgery*; D003937:Diagnosis, Differential; D005260:Female; D005720:Gamma Rays; D006207:Half-Life; D006801:Humans; D007457:Iodine Radioisotopes / Q000191:economics; D015412:Mastectomy, Segmental / Q000191:economics / Q000379:methods*; D009367:Neoplasm Staging; D010330:Patents as Topic; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D021701:Sentinel Lymph Node Biopsy; D013667:Technetium / Q000191:economics; D014025:Titanium; D014481:United States
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D013667:Technetium; D014025:Titanium