Antihyperglycemic and antihyperlipidemic effects of Ziziphus vulgaris L. on streptozocin-induced [corrected] diabetic adult male Wistar rats.
Herbal medicine and medical plants such as Ziziphus vulgaris L. are widely used for the treatment of diseases such as diabetes mellitus. We investigated the effects of water extracts of Ziziphus vulgaris L. fruit on serum glucose, triglycerides, LDL-cholesterol, HDL-cholesterol and activities of aminotransferase enzymes inreptozocin-induced diabetic adult male rats. Continuous supplementation of this water extract by gavage at doses of 0.25, 0.5, 1, 1.5 and 2 g/kg in 0.5 ml distilled water in diabetic rats resulted in a significant decrease of fasting blood glucose and LDL-cholesterol and triglyceride levels after 14 days. The levels of HDL-cholesterol and insulin, and activities of serum aminotransaminase enzymes, alanine aminotransferase and aspartate aminotransferase were not changed significantly in the extract-supplemented group compared to the control group.
Solati
Jalal
J
Young Researchers Club, Islamic Azad University-Karaj branch, PO Box 31485-312, Karaj, Iran. Solati@kiau.ac.ir
Soleimani
Nastaran
N
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D000960:Hypolipidemic Agents / Q000008:administration & dosage*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D031957:Ziziphus / Q000737:chemistry*
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D013311:Streptozocin