Multidisciplinary approach for in-deep assessment of joint prosthesis failure.
In spite of advancement in biomaterials and biomechanics, in development of new osteo-integrative materials and coatings, and in macro- micro- component design, a non negligible fraction of the implanted prosthesis fails before the expected lifetime. A prospective observational clinical study has been conducted to define and apply a set of experimental techniques to in-deep assess the failure of joint prosthesis. Microbiological, histological and micro-structural techniques were implemented to specifically address phenomena occurring at the tissue-implant interface. Results obtained from 27 cases of prosthetic joint failure are discussed in terms of sensitivity and specificity. A procedural flow-chart is finally proposed for the assessment of joint prosthesis failure.
Tessarolo
F
F
Interdepartmental Centre for Biotechnologies and Department of Physics, University of Trento, 35100, Trento, Italy. tessaro@science.unitn.it
Caola
I
I
Piccoli
F
F
Dorigotti
P
P
Demattè
E
E
Molinari
M
M
Malavolta
M
M
Barbareschi
M
M
Caciagli
P
P
Nollo
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019643:Arthroplasty, Replacement / Q000379:methods*; D001672:Biocompatible Materials / Q000737:chemistry; D001696:Biomechanical Phenomena; D005260:Female; D006801:Humans; D007595:Joint Prosthesis; D007596:Joints / Q000473:pathology; D008297:Male; D008422:Materials Testing; D008828:Microbiological Techniques; D008875:Middle Aged; D011446:Prospective Studies; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012107:Research Design
D001672:Biocompatible Materials