Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction.
Bach
Anders
A
Department of Medicinal Chemistry, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Chi
Celestine N
CN
Pang
Gar F
GF
Olsen
Lars
L
Kristensen
Anders S
AS
Jemth
Per
P
Strømgaard
Kristian
K
D000595:Amino Acid Sequence; D001665:Binding Sites; D003198:Computer Simulation; D019281:Dimerization; D015195:Drug Design; D006801:Humans; D008024:Ligands; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D010949:Plasma / Q000378:metabolism; D017434:Protein Structure, Tertiary; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism*
D008024:Ligands; D009419:Nerve Tissue Proteins; D010455:Peptides; D016194:Receptors, N-Methyl-D-Aspartate; C033652:postsynaptic density proteins