Conditions and drugs interfering with thyroxine absorption.
Food, dietary fibre and espresso coffee interfere with the absorption of levothyroxine. Malabsorptive disorders reported to affect the absorption of levothyroxine include coeliac disease, inflammatory bowel disease, lactose intolerance as well as Helicobacter pylori (H. pylori) infection and atrophic gastritis. Many commonly used drugs, such as bile acid sequestrants, ferrous sulphate, sucralfate, calcium carbonate, aluminium-containing antacids, phosphate binders, raloxifene and proton-pump inhibitors, have also been shown to interfere with the absorption of levothyroxine.
Liwanpo
Llanyee
L
Department of Endocrinology, VA Greater Los Angeles Healthcare System, Endocrinology 111D, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA. liwanpol@cshs.org
Hershman
Jerome M
JM
D000536:Aluminum Hydroxide / Q000009:adverse effects; D000818:Animals; D000863:Antacids / Q000009:adverse effects; D001682:Biological Availability; D002119:Calcium Carbonate / Q000009:adverse effects; D002446:Celiac Disease / Q000503:physiopathology; D003069:Coffee / Q000009:adverse effects; D004043:Dietary Fiber / Q000009:adverse effects; D004347:Drug Interactions; D005260:Female; D005502:Food; D005757:Gastritis, Atrophic / Q000503:physiopathology; D016481:Helicobacter Infections / Q000503:physiopathology; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007787:Lactose Intolerance / Q000503:physiopathology; D008286:Malabsorption Syndromes / Q000503:physiopathology; D013974:Thyroxine / Q000493:pharmacokinetics*
D000863:Antacids; D003069:Coffee; D004043:Dietary Fiber; D000536:Aluminum Hydroxide; D002119:Calcium Carbonate; D013974:Thyroxine