title: [An association study of brain-derived neurotrophic factor gene polymorphism in bipolar disorders].
abstract: OBJECTIVE
  To investigate the association between brain-derived neurotrophic factor (BDNF) gene polymorphism and bipolar disorder.
  
  
  METHODS
  Single nucleotide polymorphisms rs6265 and rs11030101 in BDNF gene were detected and compared between 228 patients with bipolar disorder and 361 healthy controls.
  
  
  RESULTS
  The genotypes, alleles and combinative genotype of BDNF gene single nucleotide polymorphism rs6265 and rs11030101 did not show significant differences between two groups. There were also no significant differences in genotypes and combinative genotypes between diagnostic subtypes, genders and on-set age of bipolar disorder and controls.
  
  
  CONCLUSIONS
  This study did not found that BDNF gene single nucleotide polymorphism rs6265 and rs11030101 are associated with bipolar disorders.
authors: Department of Psychiatry, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors: Chen-yu
authors: CY
authors: Ye
authors: Ye-qing
authors: YQ
authors: Xu
authors: Hua
authors: H
authors: Hu
authors: Shun-ying
authors: SY
authors: Yu
authors: Dong-xiang
authors: DX
authors: Wang
authors: Shen-xun
authors: SX
authors: Shi
authors: Li-wei
authors: LW
authors: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor