title: Quercetin supplementation does not alter antioxidant status in humans.
abstract: This study measured the influence of ingesting quercetin on plasma measures for oxidative stress and antioxidant capacity. Male and female subjects (n = 1002) varying in age (18-85 years) and body mass index (BMI) (16.7-52.7 kg/m(2)) were studied. Subjects were randomized to one of three groups using double-blinded methods: placebo, 500 mg or 1000 mg quercetin/day with 125 mg or 250 mg vitamin C/day, respectively. Pre- and post-study fasting blood samples show that plasma quercetin increased in a dose-responsive manner. The pattern of change in plasma F(2)-isoprostanes, oxidized low density lipoprotein, reduced glutathione, ferric reducing ability of plasma (FRAP) and oxygen radical absorbance capacity (ORAC) did not differ between supplementation groups or after adjustment for gender, age, BMI and disease status. In summary, quercetin supplementation over 12 weeks in doses of 500 mg or 1000 mg/day significantly increased plasma quercetin levels, but had no influence on several measures of oxidative stress and antioxidant capacity.
authors: North Carolina Research Campus, Appalachian State University, Human Performance Laboratory, Plants for Human Health Building, 600 Laureate Way, Kannapolis, NC 28081, USA. shanelyra@appstate.edu
authors: R Andrew
authors: RA
authors: Shanely
authors: Amy M
authors: AM
authors: Knab
authors: David C
authors: DC
authors: Nieman
authors: Fuxia
authors: F
authors: Jin
authors: Steven R
authors: SR
authors: McAnulty
authors: Michael J
authors: MJ
authors: Landram
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D011794:Quercetin / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000975:Antioxidants; D011794:Quercetin