Pharmacophore model of influenza neuraminidase inhibitors--a systematic review.
Recently, the worldwide spread of A/H5N1 avian influenza with high virulence has highlighted the potential threat of a human influenza pandemic. The viral surface glycoprotein, neuraminidase (NA), has been found to be a potential target to control influenza virus. With an understanding of the enzyme mechanism, the X-ray crystallographic structures of NA and its substrate or inhibitors, and progress in computational chemistry, the information about NA binding sites and pharmacophore models is derived from existing inhibitors and will serve as design guidelines of more potent agents against NA. This article gives a systematic review of the recent advances in this area.
Gong
Jian-Zhi
JZ
Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong, PR China. drgongjianzhi@yahoo.com.cn
Liu
Yu
Y
Xu
Wen-Fang
WF
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008956:Models, Chemical; D009439:Neuraminidase / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000201:enzymology*; D021281:Quantitative Structure-Activity Relationship; D014961:X-Ray Diffraction
D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D009439:Neuraminidase