Signal transduction in the human thyrocyte and its perversion in thyroid tumors.
The study of normal signal transduction pathways regulating the proliferation and differentiation of a cell type allows to predict and to understand the perversions of these pathways which lead to tumorigenesis. In the case of the human thyroid cell, three cascades are mostly involved in tumorigenesis: The pathways and genetic events affecting them are described. Caveats in the use of models and the interpretation of results are formulated and the still pending questions are outlined.
Roger
Pierre P
PP
I.R.I.B.H.M., Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B - 1070 Bruxelles, Belgium.
van Staveren
Wilma C G
WC
Coulonval
Katia
K
Dumont
Jacques E
JE
Maenhaut
Carine
C
D000818:Animals; D052138:Genes, Neoplasm / Q000235:genetics; D006801:Humans; D015398:Signal Transduction / Q000235:genetics; D013961:Thyroid Gland / Q000378:metabolism* / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*