title: Detection and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates in Canada: results from the Canadian Nosocomial Infection Surveillance Program, 1995-2006.
abstract: We describe the epidemiology of heterogeneously resistant Staphylococcus aureus (hVISA) identified in Canadian hospitals between 1995 and 2006. hVISA isolates were confirmed by the population analysis profiling-area under the curve method. Only 25 hVISA isolates (1.3% of all isolates) were detected. hVISA isolates were more likely to have been health care associated (odds ratio [OR], 5.1; 95% confidence interval [CI], 1.9 to 14.2) and to have been recovered from patients hospitalized in central Canada (OR, 3.0; 95% CI, 1.2 to 7.4). There has been no evidence of vancomycin "MIC creep" in Canadian strains of methicillin (meticillin)-resistant S. aureus, and hVISA strains are currently uncommon.
authors: Department of Laboratory Medicine & Pathobiology, University of Toronto, and Hospital for Sick Children, Toronto, Ontario, Canada.
authors: Heather J
authors: HJ
authors: Adam
authors: Lisa
authors: L
authors: Louie
authors: Christine
authors: C
authors: Watt
authors: Denise
authors: D
authors: Gravel
authors: Elizabeth
authors: E
authors: Bryce
authors: Mark
authors: M
authors: Loeb
authors: Anne
authors: A
authors: Matlow
authors: Allison
authors: A
authors: McGeer
authors: Michael R
authors: MR
authors: Mulvey
authors: Andrew E
authors: AE
authors: Simor
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002170:Canada / Q000453:epidemiology; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000453:epidemiology; D014640:Vancomycin / Q000627:therapeutic use*; D020713:Vancomycin Resistance / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin