[Streptomyces globisporus 1912 mutants highly sensitive to ultraviolet radiation, their antibiotic activity and reparation ability].
Twenty five mutants defective in biosynthesis of antitumor antibiotic landomycin E and 22 mutants with higher level biosynthesis of this antibiotic were obtained after nitrosoguanidine mutagenic treatment of wild strain of Streptomyces globisporus 1912 spores. Six of them (5 mutants of LndE and 1 mutant of LndE+) were found to carry uvs-mutation responsible for high level UV-sensitivity. Uvs-mutants 1912-11 and 1912-16 were highly sensitive to the action of nitrous acid, hydrogen peroxide and methyl-methane-sulfonate.
Lavrinchuk
V Ia
VIa
Kushkina
A I
AI
Matseliukh
B P
BP
D000617:Aminoglycosides / Q000096:biosynthesis*; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D004260:DNA Repair; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D050296:Microbial Viability / Q000187:drug effects / Q000528:radiation effects; D009154:Mutation; D009608:Nitrous Acid / Q000494:pharmacology; D013171:Spores, Bacterial / Q000187:drug effects / Q000528:radiation effects; D013302:Streptomyces / Q000187:drug effects / Q000235:genetics / Q000378:metabolism / Q000528:radiation effects*; D014466:Ultraviolet Rays
D000617:Aminoglycosides; D000903:Antibiotics, Antineoplastic; C113593:landomycin E; D008741:Methyl Methanesulfonate; D006861:Hydrogen Peroxide; D009608:Nitrous Acid