title: In vitro cytotoxicity testing and the application of elastic interconnection technology for short-term implantable electronics.
abstract: An electronic device was fabricated consisting of 2 flexible electronic circuit islands, interconnected by a 7 cm long elastic interconnection, which could be elongated for at least 50%. This interconnection was based on gold conductor tracks following a 2-D spring pattern, embedded in a biocompatible silicone elastomer. The complete device was embedded in the same silicone elastomer. An in vitro cytotoxicity extraction test, executed on small test-samples in accordance with the ISO 10 993-1 guidelines, revealed that the applied silicone encapsulation to these samples functioned as a good seal for at least 8 days.
authors: CMST, IMEC/Ghent University, Gent-Zwijnaarde, Belgium. dominique.brosteaux@elis.ugent.be
authors: Dominique
authors: D
authors: Brosteaux
authors: Evi
authors: E
authors: Lippens
authors: Ria
authors: R
authors: Cornelissen
authors: Etienne
authors: E
authors: Schacht
authors: Riccardo
authors: R
authors: Carta
authors: Philippe
authors: P
authors: Jourand
authors: Robert
authors: R
authors: Puers
authors: Fabrice
authors: F
authors: Axisa
authors: Thomas
authors: T
authors: Vervust
authors: Frederick
authors: F
authors: Bossuyt
authors: Jan
authors: J
authors: Vanfleteren
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002645:Chickens; D004582:Electronics, Medical / Q000295:instrumentation* / Q000379:methods*; D019736:Prostheses and Implants / Q000009:adverse effects*; D012828:Silicones / Q000737:chemistry
chemical_list: D012828:Silicones