Human papillomavirus in rare unilateral benign intranasal tumours.
BACKGROUND
Inverted papilloma (IP), oncocytic papilloma (OP), respiratory epithelial adenomatoid hamartoma (REAH) and capillary hemangioma (CH) are benign and rare tumours. OP and IP are associated with squamous cell carcinoma (SCC). Human papillomavirus (HPV) may play a role in malignant transformation.


OBJECTIVE
We aimed to investigate the presence of HPV, inflammation, epithelial dysplasia, and prognostic markers including proliferative cell nuclear antigen (PCNA), epidermal growth fac- tor receptor (EGFR) and p53 in tissue specimens from rare unilateral intranasal benign tumours.


METHODS
Presence of HPV DNA was detected by PCR. Proliferative cell nuclear antigen, EGFR, p53 expression and the presence of HPV type 16 in tissues were determined by immuno-histochemical analysis.


RESULTS
We determined the presence of HPV DNA in 2 of 6 IP cases, in one CH patient and one OP patient, but the REAH patient was negative. Histologically, only one specimen with IP was positive for HPV type 16 being the high risk type. The remaining cases were considered as low risk type HPV.


CONCLUSIONS
Although our patient numbers are limited, there is a significant association between IP and HPV. This is the first study showing the cooccurrence of CH and OP with HPV.
Kirdar
Sevin
S
Department of Microbiology and Clinical Microbiology, School of Medicine, Adnan Menderes University, Aydin, Turkey.
Basak
Sema
S
Odobasi
Onur
O
Doger
Furuzan Kacar
FK
Erpek
Gokhan
G
D000328:Adult; D000368:Aged; D052685:Alphapapillomavirus / Q000302:isolation & purification* / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D004279:DNA, Viral / Q000032:analysis; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D018324:Hemangioma, Capillary / Q000821:virology*; D052162:Human papillomavirus 16 / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000821:virology; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D004279:DNA, Viral; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53; C512478:EGFR protein, human; D066246:ErbB Receptors