title: Detection method and toxicity study of a new disinfection by-product, 2,2,4-trichloro-5-methoxycyclopenta-4-ene-1,3-dione (TCMCD), in chlorinated drinking water.
abstract: The detection method of 2,2,4-trichloro-5-methoxycyclopenta-4-ene-1,3-dione (TCMCD), a new disinfection by-product, was established and optimized. Drinking water samples from eight cities in Jiangsu Province, China, were analyzed and TCMCD was detected ranging from 42 to 171 ng/L among the water samples from the three cities. Toxicity of TCMCD was studied using the exposure of zebrafish and the human peripheral blood lymphocyte micronucleus assay. The results showed that TCMCD is fatal to zebrafish embryos and is a potential mutagen to human beings.
authors: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, PR China.
authors: Xing
authors: X
authors: Shen
authors: Zhijuan
authors: Z
authors: Shao
authors: Qiming
authors: Q
authors: Xian
authors: Huixian
authors: H
authors: Zou
authors: Shixiang
authors: S
authors: Gao
authors: Jinqi
authors: J
authors: Zhang
mesh_terms: D000818:Animals; D002681:China; D003517:Cyclopentanes / Q000032:analysis* / Q000302:isolation & purification / Q000633:toxicity*; D004203:Disinfection; D004625:Embryo, Nonmammalian / Q000187:drug effects; D005843:Geography; D054879:Halogenation / Q000187:drug effects*; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000032:analysis* / Q000302:isolation & purification / Q000633:toxicity*; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects; D009152:Mutagenicity Tests; D016019:Survival Analysis; D023382:Toxicity Tests, Acute / Q000379:methods*; D014881:Water Supply / Q000032:analysis*; D015027:Zebrafish / Q000196:embryology
chemical_list: C510750:2,2,4-trichloro-5-methoxycyclopent-4-ene-1,3-dione; D003517:Cyclopentanes; D006843:Hydrocarbons, Chlorinated