Rotavirus and adenovirus frequency among patients with acute gastroenteritis and their relationship to clinical parameters: a retrospective study in Turkey.
Diarrhea is the third leading cause of death related to infectious diseases all over the world. The diseases related to viral gastroenteritis are gradually increasing, particularly in the developed countries. The purpose of our study was to determine the frequency and to investigate the clinical manifestations of acute rotavirus and adenovirus gatroenteritis and to assess the diagnostic value of the related clinical findings.



In 2007-2008 patients with diarrhea and/or vomiting attended to Yeditepe University Hospital and related clinics, Istanbul, were studied. The rotavirus and/or adenovirus antigen in stool of these patients were investigated. Data regarding clinical findings were collected from the electronic records, retrospectively. Age, gender, symptoms, fever, antibiotic use, vomiting, number of vomiting and diarrhaeae, dehydration, abdominal pain, the other pathological physical examination findings were analyzed by the physicians in the study group. To investigate the rotavirus and adenovirus antigen CerTest Rota-Adeno Blister Test (CerTest, Biotec, Spain), a qualitative immunochromotographic assay was used. Statistical analysis wasperformed with SPSS v. 11,5 statistical software. X2 test was used for bivariate and logistic regression analysis was used for multivariate analysis.



Rotavirus positivity was 18,7% (n = 126). Concomitantly, in 596 cases adenovirus antigen test were also performed. Adenovirus positivity was 8,9% (n = 53) and rota-adenovirus co-infection was 4,4% (n = 26). Most of rotavirus positive cases were seen in December, January, February and March (p < 0.001). In clinical parameters, there was a significant difference between rotavirus positive cases and negative cases regarding to vomiting, dehydration and vomiting and diarrhea coexistence (respectively p = 0.010, p < 0.00, p = 0.007).



Rotavirus can be seen in all age groups, but more frequently in childhood. Although there is no clinical gold standard to distinguish the rotavirus cases from the other gastroenteritis agents, the findings of dehydration and vomiting-diarrhea coexistence, considering months of referral may lead clinician to perform rapid antigen tests and affect approach to the treatment. Prospective studies with representative samples are needed to determine the rotavirus and adenovirus incidence and to develop safe and reliable protective policies in our country.
Akan
Hülya
H
Department of Family Medicine, Yeditepe University Faculty of Medicine, İnönü Mahallesi, Kayışdağı Cad, 26 Ağustos Yerleşimi, 34755 Kadıköy, İstanbul, Turkey.
İzbırak
Güldal
G
Department of Family Medicine, Yeditepe University Faculty of Medicine, İnönü Mahallesi, Kayışdağı Cad, 26 Ağustos Yerleşimi, 34755 Kadıköy, İstanbul, Turkey.
Gürol
Yesim
Y
Department of Microbiology and Clinical Microbiology, Yeditepe University Faculty of Medicine, İnönü Mahallesi, Kayışdağı Cad, 26 Ağustos Yerleşimi, 34755 Kadıköy, İstanbul, Turkey.
Sarıkaya
Sezgin
S
Department of Emergency Medicine, Yeditepe University Faculty of Medicine, İnönü Mahallesi, Kayışdağı Cad, 26 Ağustos Yerleşimi, 34755 Kadıköy, İstanbul, Turkey.
Gündüz
Tehlile S
TS
Department of Microbiology and Clinical Microbiology, Yeditepe University Faculty of Medicine, İnönü Mahallesi, Kayışdağı Cad, 26 Ağustos Yerleşimi, 34755 Kadıköy, İstanbul, Turkey.
Yılmaz
Gülden
G
Department of Microbiology and Clinical Microbiology, Yeditepe University Faculty of Medicine, İnönü Mahallesi, Kayışdağı Cad, 26 Ağustos Yerleşimi, 34755 Kadıköy, İstanbul, Turkey.
Hayran
Osman
O
Faculty of Health Sciences, Yeditepe University Faculty of Medicine, İnönü Mahallesi, Kayışdağı Cad, 26 Ağustos Yerleşimi, 34755 Kadıköy, İstanbul, Turkey.
Vitrinel
Ayca
A
Department of Pediatric Child Health and Diseases, Yeditepe University Faculty of Medicine, İnönü Mahallesi, Kayışdağı Cad, 26 Ağustos Yerleşimi, 34755 Kadıköy, İstanbul, Turkey.