title: Formation of nanosized organic molecular crystals on engineered surfaces.
abstract: The pharmaceutical industry has great interest in organic molecular nanosized crystals because their enhanced solubility and dissolution rate can potentially enhance drug bioavailability. In this work, patterned engineered surfaces were used to crystallize glycine with a lateral dimension below 200 nm in a confined volume while controlling supersaturation. Bifunctional patterned surfaces with hydrophilic islands, as small as 500 nm, surrounded by hydrophobic regions were prepared using lithography and self assembled monolayers. Individual glycine crystals under 200 nm were formed from the confined solutions wetting each hydrophilic island, while supersaturation was controlled by slow antisolvent diffusion. Individual crystals were characterized with AFM and Raman spectroscopy and determined to be the metastable beta form. The solubility enhancement as a function of crystal size was measured, and the solubility of crystals with a radius of 100 nm or less was estimated.
authors: Department of Chemical and Biological Engineering, Illinois Institute of Technology, Chicago, Illinois 60616, USA.
authors: Kitae
authors: K
authors: Kim
authors: In Sung
authors: IS
authors: Lee
authors: Andrea
authors: A
authors: Centrone
authors: T Alan
authors: TA
authors: Hatton
authors: Allan S
authors: AS
authors: Myerson
mesh_terms: D003460:Crystallization / Q000379:methods*; D015195:Drug Design; D005998:Glycine; D018625:Microscopy, Atomic Force; D053758:Nanoparticles / Q000737:chemistry*; D012995:Solubility; D013059:Spectrum Analysis, Raman
chemical_list: D005998:Glycine