[Effects of perindopril and spirolactone on plasma aldosterone and left atrial remodeling in a canine model of atrial fibrillation].
OBJECTIVE
To investigate the effects of perindopril and spirolactone on plasma aldosterone (Ald) and left atrial remodeling and function in a canine model of atrial fibrillation (AF).


METHODS
Adult dogs were randomly assigned to receive normal diet (group A), perindopril (group B, 1 mgxkg(-1)xd(-1)) and spironolactone (group C, 10 mgxkg(-1)xd(-1), n = 6 each) and rapid paced (500 beats/min) for 8 weeks. Plasma Ald levels as well as atrial dimension and function at baseline and at 4 and 8 weeks after pacing were measured by RIA and echocardiography, respectively. Incidence of maintained AF and AF duration were recorded when pacing was stopped after 8 weeks of pacing. Left and right atrial tissues were collected for measurements of tissue Ald levels and fibrosis.


RESULTS
Plasma Ald was similar among groups at baseline (P > 0.05) and significantly increased post 4 and 8 weeks pacing in group A (P < 0.05) while remained unchanged post pacing in group B and C (P > 0.05) compared to respective baseline level. Atrial Ald was significantly lower in group B and C compared that in group A post 8 weeks pacing (P < 0.05). Left atrial dimension, end-systolic and end-diastolic volume were significantly increased while left atrial ejection fraction (LAEF) was significantly reduced post pacing in group A (all P < 0.05 vs. baseline) and thses changes were significantly attenuated in group B and C (P < 0.05 vs. group A). Incidence of maintained AF and AF duration post pacing as well as interstitial collagen volume fraction were significantly lower in group B and C compared those in group A (P < 0.05).


CONCLUSIONS
Increased Ald might be an important pathogenesis for AF formation and progression, spironolactone and perindopril could attenuate atrial remodeling and improve atrial function by reducing plasma and tissue Ald levels in this model.
Luo
Tai-yang
TY
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Liu
Xiao-hui
XH
DU
Xin
X
Liu
Xing-peng
XP
Lei
Tao
T
Wang
Hai-yun
HY
Shi
Jia-hai
JH
D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D001281:Atrial Fibrillation / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D016275:Atrial Function; D004195:Disease Models, Animal; D004285:Dogs; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology; D020913:Perindopril / Q000494:pharmacology*; D013148:Spironolactone / Q000494:pharmacology*
D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone; D000450:Aldosterone; D020913:Perindopril