title: [Acute T cells lymphoblastic leukemia with a t(1;19)(q23;p13) and E2A-PBX1 in an adult: one case report and literature review].
abstract: OBJECTIVE
  To report a case of T cell acute lymphoblastic leukemia (ALL) with t(1;19)(q23;pl3) and E2A-PBX1 fusion gene, which is a characteristic translocation of childhood B cell ALL (B-ALL).
  
  
  METHODS
  The chromosome, karyotype, immunophenotype and mRNA for fusion gene of the leukemic cells were examined by cytogenetic analysis, flow cytometry (FCM) and reverse transcriptase PCR (RT-PCR), respectively.
  
  
  RESULTS
  The cytogenetic karyotype of the patient was 47, XY, 9p+, 15p+, 17q-, der(19), t(1;19)(q23;pl3)\[5\]/46, XY\[15\], and E2A-PBX1 was positive. The leukemic cells expressed T cell markers. The patient was induced with hyper CVAD regimen (cyclophosphamide, vincristine, adriamycin, and dexamethasone), and achieved complete remission with normal cytogenetic karyotype 46 XY\[10\], and negative E2A-PBX1.
  
  
  CONCLUSIONS
  t(1;19)E2A-PBX1(+) can be implicated in adult T-ALL, besides childhood B-ALL.
authors: The First Affiliated Hospital of Soochow University, Jiangsu Insititute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Suzhou 215006, China.
authors: Guang-Sheng
authors: GS
authors: He
authors: Xu-Hui
authors: XH
authors: Zhang
authors: Li
authors: L
authors: Yao
authors: Ri
authors: R
authors: Zhang
authors: Zi-Xing
authors: ZX
authors: Chen
authors: De-Pei
authors: DP
authors: Wu
authors: Ai-Ning
authors: AN
authors: Sun
authors: Zheng-Ming
authors: ZM
authors: Jin
authors: Hui-Ying
authors: HY
authors: Qiu
authors: Xiao-Hui
authors: XH
authors: Hu
mesh_terms: D000328:Adult; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D018398:Homeodomain Proteins; D015514:Oncogene Proteins, Fusion; C089847:E2A-Pbx1 fusion protein