The pharmacokinetics of a long-acting OROS hydromorphone formulation.
BACKGROUND
New formulations of opiods can provide round-the-clock pain relief to improve pain management and quality of life for patients with chronic pain.


METHODS
Information and comments on the pharmacokinetic processes associated with a new once-daily formulation of the potent opiod hydromorphone.


RESULTS
This review presents an overview of data from several small pharmacokinetic studies to gain a better perspective on the pharmacokinetic properties of a new long-acting formulation of hydromorphone.


CONCLUSIONS
The development of advanced oral formulation that deliver analgesic drugs over an extended period provides new solutions to improve pain management and quality of life for patients with chronic pain.
Turgeon
J
J
Centre Hospitalier de l'Université de Montréal, Hôtel-Dieu, Masson Pavilion, 3850 Saint-Urbain Street, Room 8-109, Montreal, Quebec H2W 1T7, Canada. Jacques.turgeon.chum@ssss.gouv.qc.ca
Gröning
R
R
Sathyan
G
G
Thipphawong
J
J
Richarz
U
U
D000284:Administration, Oral; D002908:Chronic Disease; D003692:Delayed-Action Preparations; D006801:Humans; D004091:Hydromorphone / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy
D003692:Delayed-Action Preparations; D004091:Hydromorphone