Innate immunity and gut-microbe mutualism in Drosophila.
Metazoan guts face a wide variety of microorganisms upon exposure to the environment, including beneficial symbionts, non-symbionts, food-borne microbes and life-threatening pathogens. Recent evidence has shown that the innate immunity of gut epithelia, such as anti-microbial peptide- and reactive oxygen species-based immune systems, actively participate in gut-microbe homeostasis by shaping the commensal community while efficiently eliminating unwanted bacteria. Therefore, elucidation of the regulatory mechanism by which gut innate immunity occurs at the molecular level will provide a novel perspective of gut-microbe mutualisms as well as of gut diseases caused by alterations in the innate immunity.
Ryu
Ji-Hwan
JH
Division of Life and Pharmaceutical Science, Department of Life Science, Department of Bioinspired Science, and National Creative Research Initiative Center for Symbiosystem, Ewha Woman's University, Seoul 120-750, South Korea.
Ha
Eun-Mi
EM
Lee
Won-Jae
WJ
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000276:immunology; D004330:Drosophila / Q000382:microbiology* / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000382:microbiology*; D015971:Gene Expression Regulation, Enzymologic; D054884:Host-Pathogen Interactions; D007113:Immunity, Innate; D017382:Reactive Oxygen Species / Q000276:immunology; D015398:Signal Transduction; D013559:Symbiosis
D023181:Antimicrobial Cationic Peptides; D017382:Reactive Oxygen Species