[A prospective study on the association between dyslipidemia and hypertension].
OBJECTIVE
To discuss the risks of hypertension development with relation to the level of lipid variables among populations who had normal blood pressure at baseline study.


METHODS
In April 2000, under the support of project "prevention of metabolic syndrome and multi-metabolic disorders in Jiangsu province", a cohort study was performed to obtain the baseline data among 8685 persons from age 34 to 74. In June of 2006, a follow-up investigation was carried out among those who had been in the study for 5 years after the baseline study started. 2603 persons who met the selection criteria and showed normal blood pressure during baseline study, were recruited in this investigation. The interval from the baseline to the follow-up studies was 6.38 years on average. Relationship between the risk of developing hypertension and the baseline level of lipid variables were analyzed.


RESULTS
Relations between baseline lipid levels and the incidence of hypertension during the follow-up was discovered. In gender and age adjusted model, the lipid variables were all associated with hypertension (trend test, P<0.01). In multivariable-adjusted model, HDL-C [aRR=0.71 (95%CI: 0.61-0.99)], non-HDL-C [aRR=1.28 (95%CI: 1.14-1.83)], TC/HDL-C ratio [aRR=1.41 (95%CI: 1.25-2.03)] and TG [aRR=1.49 (95%CI: 1.30-2.13)] were again associated with hypertension (trend test, P<0.05). Even the aRR was much weakened after the baseline SBP, DBP were adjusted with Cox model, the significant relation of hypertension to HDL-C, TC/HDL-C ratio and TG still existed. Excluding the two factors of obesity (BMI> or =28) and diabetes which had been recognized in marked linking with hypertension, lipid variables were still associated with hypertension.


CONCLUSIONS
Dyslipidemia might occur before being hypertensive. Hypertension was associated with HDL-C, TC/HDL-C and TG or even exclusion of obesity, diabetes and factors of smoking and drinking or baseline level of SBP, DBP were adjusted.
Guo
Zhi-Rong
ZR
School of Radiological Medicine and Public Health, Soochow University, Suzhou, China.
Hu
Xiao-Shu
XS
Wu
Ming
M
Zhou
Ming-Hao
MH
Zhou
Zheng-Yuan
ZY
D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D050171:Dyslipidemias / Q000150:complications*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology*; D015994:Incidence; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D002784:Cholesterol