Critical care issues in oncological surgery patients.
As life expectancy increases and advances in cancer treatment more often convert deadly conditions into more chronic diseases, the surgical intensivist can expect to be faced with greater numbers of oncology patients undergoing aggressive surgical treatments for curative intent, prolonging survival, or primarily palliation by alleviating obstruction, infection, bleeding, or pain. Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) are a paradigm for the emerging field of multimodal aggressive oncological surgery. This article describes the CRS/HIPEC technique, and discusses the most common postoperative complications and critical care issues in these patients, including anastomotic leaks, intestinal perforation, abscesses, and intra-abdominal bleeding. The leading cause of mortality is sepsis leading to multiple organ failure, and such patients are at particularly higher risk due to the extensive CRS and HIPEC. The intensivist must be vigilant to ensure that source control is not overlooked. This process is a very difficult one, made even more challenging by the blunting of physiologic responses and the frequent absence of the classic acute abdomen.
Ahmed
Sanam
S
Division of Critical Care Medicine, Department of Surgery, The Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Oropello
John M
JM
D000008:Abdominal Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003422:Critical Care / Q000379:methods*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007263:Infusions, Parenteral; D007362:Intensive Care Units; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D018805:Sepsis / Q000209:etiology; D013514:Surgical Procedures, Operative / Q000009:adverse effects / Q000379:methods
D000970:Antineoplastic Agents