Mucin complexes of nanomaterials: first biochemical encounter.
In recent years, the exposure of biological systems to various nanomaterials has become an issue of great public concern. Although living organisms have arrays of biological defense mechanisms against exposure to exogenous compounds, the biochemical mechanisms allowing various nanomaterials to enter the body are not well understood. A unique example of a typical mucosal glycoprotein capable of binding and solubilizing nanomaterials in physiological solution is provided, suggesting a possible route for entry into biological systems.
Belgorodsky
Bogdan
B
School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel.
Drug
Eyal
E
Fadeev
Ludmila
L
Hendler
Netta
N
Mentovich
Elad
E
Gozin
Michael
M
D000818:Animals; D002021:Buffers; D002417:Cattle; D002850:Chromatography, Gel; D037741:Fullerenes / Q000378:metabolism; D008024:Ligands; D008027:Light; D018625:Microscopy, Atomic Force; D016252:Microscopy, Scanning Tunneling; D009077:Mucins / Q000378:metabolism* / Q000648:ultrastructure; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D037742:Nanotubes, Carbon / Q000737:chemistry; D012542:Scattering, Radiation; D012996:Solutions; D013363:Submandibular Gland / Q000737:chemistry
D002021:Buffers; D037741:Fullerenes; D008024:Ligands; D009077:Mucins; D037742:Nanotubes, Carbon; D012996:Solutions