title: Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia.
abstract: The Philadelphia (Ph(1)) chromosome arising from the reciprocal t(9;22) translocation is found in more than 90% of chronic myeloid leukemia (CML) patients and results in the formation of the chimeric fusion gene BCR-ABL. However, a small proportion of patients with CML have simple or complex variants of this translocation, involving various breakpoints in addition to 9q34 and 22q11. We report five CML cases carrying variant Ph translocations involving both chromosomes 9 and 22 as well as chromosomes 3, 5, 7, 8, or 10. G-banding showed a reciprocal three-way translocation involving 3q21, 5q31, 7q32, 8q24, and 10q22 bands. BCR-ABL fusion signal on der(22) was found in all of the cases by FISH.
authors: Department of Hematology, La Fe University Hospital, 46009 Valencia, Spain.
authors: Ana
authors: A
authors: Valencia
authors: José
authors: J
authors: Cervera
authors: Esperanza
authors: E
authors: Such
authors: Eva
authors: E
authors: Barragán
authors: Pascual
authors: P
authors: Bolufer
authors: Oscar
authors: O
authors: Fuster
authors: Rosa
authors: R
authors: Collado
authors: Jesús
authors: J
authors: Martínez
authors: Miguel A
authors: MA
authors: Sanz