title: A candidate gene study of canine joint diseases.
abstract: Canine osteoarthritis (OA) commonly occurs in association with articular diseases, such as hip dysplasia (HD), elbow dysplasia (ED), or cranial cruciate ligament rupture (CCLR). We hypothesized that a common genomic risk for the development of canine joint disease and canine OA would be identified by evaluating the allele frequencies of candidate gene single nucleotide polymorphisms (SNPs) in dogs with OA associated with different articular diseases when compared with a general population of breed-matched dogs. DNA was extracted from blood samples obtained from Labrador Retrievers and Golden Retrievers surgically treated for ED, HD, and CCLR and confirmed to have radiographic evidence of OA. One hundred and thirteen SNPs in 20 candidate genes were genotyped. No significant associations were identified for SNPs or haplotypes in the candidate genes for the diseases evaluated. The candidate gene approach for the study of genetic association is unlikely to be successful for complex canine diseases such as OA without prior trait mapping evaluation.
authors: Division of Veterinary Clinical Sciences, The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, UK. dylan.clements@ed.ac.uk
authors: Dylan N
authors: DN
authors: Clements
authors: Andrea D
authors: AD
authors: Short
authors: Annette
authors: A
authors: Barnes
authors: Lorna J
authors: LJ
authors: Kennedy
authors: John F
authors: JF
authors: Ferguson
authors: Steven J
authors: SJ
authors: Butterworth
authors: Noel
authors: N
authors: Fitzpatrick
authors: Matthew
authors: M
authors: Pead
authors: David
authors: D
authors: Bennett
authors: John F
authors: JF
authors: Innes
authors: Stuart D
authors: SD
authors: Carter
authors: William E R
authors: WE
authors: Ollier
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D007592:Joint Diseases / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide