title: A case report of an uncommon sex-cord stromal tumor consisted of luteal and sertoli cells in a spayed bitch.
abstract: We report a rare case of benign sex cord-stromal tumor consisted largely of luteoma with minor portion of Sertoli cell tumor located at the position of the left ovary excision in an 11-year-old ovariectomized bitch. Granulosa cell component was lacking, and both luteal and Sertoli cell portions were entirely positive for inhibin alpha and neuron-specific enolase, whereas luteoma portion alone was positive for Wilms' tumor-1 (WT1), immunohistochemically. The results suggest that this tumor is a possible complication of incomplete ovarian excision at the time of ovariectomy and consisted of uncommon hybrid of luteal and Sertoli cells to be diagnosed as an unclassified sex cord-stromal tumor if applied in human cases. WT1-expression pattern suggested the signature of the difference in the phenotype of these cell types.
authors: Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan.
authors: Ryohei
authors: R
authors: Ichimura
authors: Makoto
authors: M
authors: Shibutani
authors: Sayaka
authors: S
authors: Mizukami
authors: Terumasa
authors: T
authors: Suzuki
authors: Yuko
authors: Y
authors: Shimada
authors: Kunitoshi
authors: K
authors: Mitsumori
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008184:Luteal Cells / Q000473:pathology; D008297:Male; D010051:Ovarian Neoplasms / Q000473:pathology / Q000662:veterinary*; D012708:Sertoli Cells / Q000473:pathology; D018312:Sex Cord-Gonadal Stromal Tumors / Q000473:pathology / Q000662:veterinary*