Metastasis: wherefore arf thou?
The small GTP-binding protein Arf6 is known to be an important regulator of the actin cytoskeleton and of cell motility associated with metastasis. A recent study identifies yet another role for Arf6 in metastasis - as a regulator of plasma-membrane-derived microvesicle release.
Premont
Richard T
RT
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. Richard.Premont@Duke.edu
Schmalzigaug
Robert
R
D000089982:ADP-Ribosylation Factor 6; D020727:ADP-Ribosylation Factors / Q000235:genetics / Q000502:physiology*; D000818:Animals; D005804:Genes, Lethal; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D015398:Signal Transduction
D000089982:ADP-Ribosylation Factor 6; D020727:ADP-Ribosylation Factors; C000715348:ARF6 protein, human; C000715727:Arf6 protein, mouse