A review of the potential effect of electroacupuncture and moxibustion on cell repair and survival: the role of heat shock proteins.
In recent years, a considerable amount of research has been focused on the underlying mechanisms of electroacupuncture and moxibustion assisted tissue repair. Intracellular protein denaturation is a significant pathological step of acute conditions such as stroke, myocardial infarction and acute pancreatitis. Protein aggregation can be observed after the protein denaturation step in chronic diseases of the central nervous system like Alzheimer's and Parkinson's disease, and also in other chronic system diseases including cataract formation. Heat shock proteins (HSPs) are fundamental for intracellular protein repair and work by preventing protein aggregation and assisting denaturated proteins to refold. Further, HSPs can also function for extracellular cell signalling. The focus of this review is to analyse the data studying electroacupuncture and moxibustion induced HSPs, and how acupuncture can survive cells from apoptosis under stress.
Cakmak
Yusuf Ozgur
YO
Medical Acupuncture Center, Medical Park Hospital, Istanbul, Turkey. ycakmak@marmara.edu.tr
D000544:Alzheimer Disease / Q000517:prevention & control; D017209:Apoptosis; D049109:Cell Proliferation; D002470:Cell Survival; D015671:Electroacupuncture / Q000379:methods*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D009071:Moxibustion / Q000379:methods*; D019636:Neurodegenerative Diseases / Q000517:prevention & control*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000517:prevention & control; D012038:Regeneration / Q000502:physiology
D006360:Heat-Shock Proteins