Vasospastic heart failure: multiple spasm may cause transient heart failure?
BACKGROUND
There have been no reports concerning the correlation between heart failure and coronary artery spasm.


RESULTS
From January 2000 to December 2007, 201 patients with heart failure were hospitalized at our institution. We could perform coronary arteriography and spasm provocation tests in 37 (22 men, 67±11 years) out of 201 patients with heart failure before discharge. Atrial fibrillation was observed in 13 patients (35%). After controlling heart failure and 24h cessation of vasoactive drugs, pharmacological spasm provocation tests were performed. Positive spasm was defined as >90%. Coronary spasm was observed in 12 patients (32%) and multiple spasm was recognized in 10 (83%) out of 12 patients. Though ejection fraction on admission was not different between the two groups (42±18% vs. 43±11%, ns), left ventricular end-diastolic and end-systolic dimension after medical therapy over 1 year was significantly smaller in patients with positive spasm than that in patients with negative spasm. There was no difference concerning medications except the administration of nitrate and nicorandil between two groups.


CONCLUSIONS
Coronary artery spasm, especially multiple spasm, may cause transient heart failure in a small part of unknown origin heart failure in Japan.
Sueda
Shozo
S
Department of Cardiology, Saiseikai Saijo Hospital, Saijo, Japan. EZF03146@nifty.com
Kohno
Hiroaki
H
Oshita
Akira
A
Izoe
Yousuke
Y
Nomoto
Takahiko
T
Fukuda
Hiroshi
H
D000210:Acute-Phase Reaction; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D000368:Aged; D044466:Asian People; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use; D003329:Coronary Vasospasm / Q000150:complications* / Q000175:diagnosis; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines; D011758:Pyrroles; D012307:Risk Factors; D013318:Stroke Volume; D016277:Ventricular Function, Left
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; C555354:EC 144; D011743:Pyrimidines; D011758:Pyrroles