title: Catalytic enantioselective hydrophosphonylation of ketimines using cinchona alkaloids.
abstract: Organocatalytic enantioselective hydrophosphonylation of ketimines using cinchona alkaloids and Na(2)CO(3) afforded products with high enantioselectivity. Both enantiomers of alpha-amino phosphonates can be prepared by using pseudoenantiomeric cinchona alkaloids. The catalyst loading of cinchona alkaloids can be reduced to 0.5 mol % without a significant loss of enantioselectivity.
authors: Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan. snakamur@nitech.ac.jp
authors: Shuichi
authors: S
authors: Nakamura
authors: Masashi
authors: M
authors: Hayashi
authors: Yuichi
authors: Y
authors: Hiramatsu
authors: Norio
authors: N
authors: Shibata
authors: Yasuhiro
authors: Y
authors: Funahashi
authors: Takeshi
authors: T
authors: Toru
mesh_terms: D002384:Catalysis; D002930:Cinchona Alkaloids / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry*; D063065:Organophosphonates / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002930:Cinchona Alkaloids; D007097:Imines; D009570:Nitriles; D063065:Organophosphonates; C542835:ketimine