Cell based-gene delivery approaches for the treatment of spinal cord injury and neurodegenerative disorders.
Cell based-gene delivery has provided an important therapeutic strategy for different disorders in the recent years. This strategy is based on the transplantation of genetically modified cells to express specific genes and to target the delivery of therapeutic factors, especially for the treatment of cancers and neurological, immunological, cardiovascular and heamatopoietic disorders. Although, preliminary reports are encouraging, and experimental studies indicate functionally and structurally improvements in the animal models of different disorders, universal application of this strategy for human diseases requires more evidence. There are a number of parameters that need to be evaluated, including the optimal cell source, the most effective gene/genes to be delivered, the optimal vector and method of gene delivery into the cells and the most efficient route for the delivery of genetically modified cells into the patient. Also, some obstacles have to be overcome, including the safety and usefulness of the approaches and the stability of the improvements. Here, recent studies concerning with the cell-based gene delivery for spinal cord injury and some neurodegenerative disorders such as amyotrophic lateral sclerosis, Parkinson's disease and Alzheimer's disease are briefly reviewed, and their exciting consequences are discussed.
Taha
Masoumeh Fakhr
MF
Department of Medical Genetic, National Institute of Genetic Engineering and Biotechnology, Shahrak-e-Pajoohesh, 15th Km, Tehran-Karaj Highway, PO Box: 14965 -161, Tehran, Iran. mftaha@nigeb.ac.ir
D000818:Animals; D017690:Cell Transplantation; D019610:Cytoprotection; D004195:Disease Models, Animal; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans; D009414:Nerve Growth Factors / Q000235:genetics / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D009474:Neurons / Q000473:pathology; D020127:Recovery of Function; D012190:Retroviridae / Q000235:genetics; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D013234:Stem Cells / Q000378:metabolism* / Q000473:pathology; D019076:Transgenes / Q000235:genetics
D009414:Nerve Growth Factors