title: Maize inbreds exhibit high levels of copy number variation (CNV) and presence/absence variation (PAV) in genome content.
abstract: Following the domestication of maize over the past approximately 10,000 years, breeders have exploited the extensive genetic diversity of this species to mold its phenotype to meet human needs. The extent of structural variation, including copy number variation (CNV) and presence/absence variation (PAV), which are thought to contribute to the extraordinary phenotypic diversity and plasticity of this important crop, have not been elucidated. Whole-genome, array-based, comparative genomic hybridization (CGH) revealed a level of structural diversity between the inbred lines B73 and Mo17 that is unprecedented among higher eukaryotes. A detailed analysis of altered segments of DNA conservatively estimates that there are several hundred CNV sequences among the two genotypes, as well as several thousand PAV sequences that are present in B73 but not Mo17. Haplotype-specific PAVs contain hundreds of single-copy, expressed genes that may contribute to heterosis and to the extraordinary phenotypic diversity of this important crop.
authors: Department of Plant Biology, University of Minnesota, Saint Paul, Minnesota, USA.
authors: Nathan M
authors: NM
authors: Springer
authors: Kai
authors: K
authors: Ying
authors: Yan
authors: Y
authors: Fu
authors: Tieming
authors: T
authors: Ji
authors: Cheng-Ting
authors: CT
authors: Yeh
authors: Yi
authors: Y
authors: Jia
authors: Wei
authors: W
authors: Wu
authors: Todd
authors: T
authors: Richmond
authors: Jacob
authors: J
authors: Kitzman
authors: Heidi
authors: H
authors: Rosenbaum
authors: A Leonardo
authors: AL
authors: Iniguez
authors: W Brad
authors: WB
authors: Barbazuk
authors: Jeffrey A
authors: JA
authors: Jeddeloh
authors: Daniel
authors: D
authors: Nettleton
authors: Patrick S
authors: PS
authors: Schnable
mesh_terms: D001483:Base Sequence; D018556:Crops, Agricultural / Q000235:genetics; D018628:Gene Dosage; D017343:Genes, Plant; D014644:Genetic Variation; D018745:Genome, Plant; D005838:Genotype; D006239:Haplotypes; D017384:Sequence Deletion; D003313:Zea mays / Q000235:genetics*