[Progress on the subcellular localization of Daxx].
As a highly conserved nuclear protein, death domain-associated protein(Daxx) plays an important role in transcriptional control, carcinogenesis, resistance to virus infection, and so on. Daxx can be localized in promyleocytic leukaemia protein oncogenic domains, nucleoplasm, nucleolus, cytoplasm, and heterochromatin. The subcellular localization of Daxx can be changed by modification or interacting with other proteins. Under cellular stress, Daxx can interact with many kinds of molecules, and thus affect its downstream signaling pathway. The purpose of this review was to discuss Daxx's subcellular localization in different conditions and its translocation between subcellular compartments.
Chen
Su-Fang
SF
Institute of Pathogenic Biology,University of South China, Hengyang, Hunan, 421001,P. R. China.
Zhu
Cui-Ming
CM
Wan
Yan-Ping
YP
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism / Q000502:physiology; D045744:Cell Line, Tumor; D002466:Cell Nucleolus / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D056970:Co-Repressor Proteins; D003593:Cytoplasm / Q000378:metabolism; D006570:Heterochromatin / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism / Q000502:physiology; D018832:Molecular Chaperones; D009687:Nuclear Proteins / Q000378:metabolism* / Q000502:physiology; D018384:Oxidative Stress; D000071156:Promyelocytic Leukemia Protein; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D056970:Co-Repressor Proteins; C106985:DAXX protein, human; C491473:Daxx protein, mouse; D006570:Heterochromatin; D047908:Intracellular Signaling Peptides and Proteins; D018832:Molecular Chaperones; D009687:Nuclear Proteins; D000071156:Promyelocytic Leukemia Protein; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; C070576:PML protein, human