title: 18F-FDG PET imaging of progressive massive fibrosis.
abstract: OBJECTIVE
  This study was to evaluate (18)F-FDG PET features of progressive massive fibrosis (PMF) and to determine the ability of FDG PET to differentiate pure PMF from PMF-associated lung cancer.
  
  
  METHODS
  (18)F-FDG PET and chest computed tomography (CT) scans were performed in 9 patients with pneumoconiosis and PMF. Patients who showed active pulmonary tuberculosis on CT scan were excluded. Pure PMF was confirmed via either fine needle aspiration biopsy (n = 6) or 12 months follow-up CT scan (n = 3). CT features and PET findings were evaluated for distribution of fibrotic masses, consolidations, and nodules on CT scan and mean and maximum standardized uptake values (SUVs) of abnormalities depicted on PET scan.
  
  
  RESULTS
  14 masses were detected from nine patients. On chest CT scan, PMF masses were noted with surrounding small nodules and distortion of parenchyma. The size of the lesions ranged from 1.2 to 6.4 cm in maximum diameter. FDG PET scans identified metabolically active lesions in all patients. Maximal SUV ranged from 3.1 to 14.6 and mean SUV ranged from 1.4 to 8.5.
  
  
  CONCLUSIONS
  FDG PET can identify PMF lesions as hypermetabolic lesions even without associated malignancy or tuberculosis. Therefore, it might have a limited role in the diagnosis of PMF with possible concurrent granulomatous inflammation or lung cancer.
authors: Department of Diagnostic Radiology, Yongin Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Yongin, Kyunggi-Do, Republic of Korea.
authors: Soo Yoon
authors: SY
authors: Chung
authors: Jae Hoon
authors: JH
authors: Lee
authors: Tae Hoon
authors: TH
authors: Kim
authors: Sang Jin
authors: SJ
authors: Kim
authors: Hyung Joong
authors: HJ
authors: Kim
authors: Young Hoon
authors: YH
authors: Ryu
mesh_terms: D000368:Aged; D044963:Biopsy, Fine-Needle; D003937:Diagnosis, Differential; D005260:Female; D005355:Fibrosis; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000473:pathology*; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D013902:Radiography, Thoracic; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18