Synthesis and Characterization of Anionic Triazine Dendrimers with a Labile Disulfide Core.
Anionic dendrimers based on melamine with disulfide bonds at the core were prepared to investigate the solubility of these architectures, the ability of these molecules to solubilize pyrene as a model drug, and the ability of these architectures to undergo thiol-disulfide exchange. The ability to solubilize pyrene is directly correlated with molecular weight of the dendrimer-aggregation of dendrons does not occur. Thiol-disulfide exchange occurs rapidly using dithiothreitol as the reductant to yield dendrimers with thiol cores that can undergo oxidation in air to yield the original dendrimer.
Zhang
Wen
W
Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA.
Lalwani
Sanjiv
S
Chouai
Abdellatif
A
Simanek
Eric E
EE