Prostate cancer epigenetics: a review on gene regulation.
Prostate cancer is the most common cancer in men in western countries, and its incidence is increasing steadily worldwide. Molecular changes including both genetic and epigenetic events underlying the development and progression of this disease are still not well understood. Epigenetic events are involved in gene regulation and occur through different mechanisms such as DNA methylation and histone modifications. Both DNA methylation and histone modifications affect gene regulation and play important roles either independently or by interaction in tumor initiation and progression. This review will discuss the genes associated with epigenetic alterations in prostate cancer progression: their regulation and importance as possible markers for the disease.
Diaw
Lena
L
SAIC-Frederick, Inc., National Cancer Institute/Advanced Technology Center, 8717 Grovemont Circle, Bethesda, Maryland 20892-4605, USA. diawl@mail.nih.gov
Woodson
Karen
K
Gillespie
John W
JW