title: Role of Toll-like receptors, NOD-like receptors and RIG-I-like receptors in endothelial cells and systemic infections.
abstract: Bacteraemia and viraemia are characterised by pathogens entering the bloodstream. Endothelial cells are among the first cells coming into contact with the microbes and also some endogenous molecules which are released by tissue damage. As part of the innate immune system, endothelial cells respond to these contacts by producing inflammatory mediators and expressing surface molecules. The initial sensing of microbial and endogenous danger-associated molecules is mediated by so-called pattern recognition receptors (PRRs). PRRs can be classified in different protein families such as the Toll-like receptors, the NOD-like receptors and the RIG-I-like receptors. By activating inflammatory gene transcription and posttranslational processing, PRRs control the immediate innate immune reaction and also the subsequent adaptive immune response. Here we describe the current knowledge of extra- and intracellular PRRs in endothelial cells and their potential role in sepsis and vascular diseases.
authors: Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany. bastian.opitz@charite.de
authors: Bastian
authors: B
authors: Opitz
authors: Julia
authors: J
authors: Eitel
authors: Karolin
authors: K
authors: Meixenberger
authors: Norbert
authors: N
authors: Suttorp
mesh_terms: D056704:Adaptive Immunity; D016470:Bacteremia / Q000276:immunology; D053487:DEAD-box RNA Helicases / Q000502:physiology*; D042783:Endothelial Cells / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D018448:Models, Immunological; D053472:Nod Signaling Adaptor Proteins / Q000502:physiology*; D018805:Sepsis / Q000276:immunology*; D051193:Toll-Like Receptors / Q000502:physiology*; D014766:Viremia / Q000276:immunology
chemical_list: D053472:Nod Signaling Adaptor Proteins; D051193:Toll-Like Receptors; D053487:DEAD-box RNA Helicases