Miltefosine treatment of Leishmania major infection: an observational study involving Dutch military personnel returning from northern Afghanistan.
In a retrospective, observational study involving 34 patients with Leishmania major infection, 31 of whom had experienced unsuccessful treatment with intralesional antimony (ilSb(v)), miltefosine proved effective. Thirty patients experienced cure after receipt of miltefosine, 3 after receipt of additional ilSb(v), and 1 after 28 daily intravenous injections of antimony. Temporary diminution of ejaculate volume was reported by 21 patients.
van Thiel
P P A M
PP
Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS and Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. p.p.vanthiel@amc.nl
Leenstra
T
T
Kager
P A
PA
de Vries
H J
HJ
van Vugt
M
M
van der Meide
W F
WF
Bart
A
A
Zeegelaar
J E
JE
van der Sluis
A
A
Schallig
H D F H
HD
van Gool
T
T
Faber
W R
WR
de Vries
P J
PJ
D000328:Adult; D000346:Afghanistan; D005260:Female; D006801:Humans; D018320:Leishmania major / Q000302:isolation & purification*; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D009426:Netherlands; D010767:Phosphorylcholine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012189:Retrospective Studies; D014195:Travel; D016896:Treatment Outcome
D010767:Phosphorylcholine; C039128:miltefosine