Assessment of the validity of the frequently used lipid indices for predicting LDL peak particle diameter in a large cohort of 1955 normal and dyslipidemic subjects.
OBJECTIVE
To assess the relationship between commonly used lipid indices and LDL peak particle diameter (LDL-PPD) in a large cohort of 1955 subjects.


METHODS
Four statistical methods were used for comparison: correlation, concordance analysis, kappa statistics and receiver operating characteristic curve (ROC) analysis.


RESULTS
Plasma triglyceride (TG) levels, TG/HDL-C, LDL-C/apoB, total cholesterol (TC)/TG, LDL-C/TG, and TG/apoB ratios were best correlated with LDL-PPD but none of these ratios accounted for more than 45% of the variation in LDL-PPD. Moreover, across the range of the lipid indices and LDL-PPD quintiles, just under 40% of the values were concordant, with kappas varying between 0.20 and 0.25. Finally, plasma TG levels and the lipid ratios yielded areas under the ROC curve between 0.78 and 0.80.


CONCLUSIONS
The present study does not support the concept that plasma TG levels and the commonly used lipid indices may be considered as adequate surrogates for the small dense LDL phenotype. Our data also indicate that various lipid indices are not superior to plasma TG levels alone as a clinical tool for prediction of the small dense LDL phenotype.
Décary
Simon
S
Lipid Research Center, CHUL Research Center, 2705 Laurier boulevard, S-102, Québec, Qc, Canada G1V 4G2.
Dumont
Geneviève
G
Lamarche
Benoît
B
Hogue
Jean-Charles
JC
Tremblay
André J
AJ
Bergeron
Jean
J
Couture
Patrick
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D008078:Cholesterol, LDL / Q000097:blood* / Q000737:chemistry*; D015331:Cohort Studies; D050171:Dyslipidemias / Q000097:blood*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D010641:Phenotype; D012372:ROC Curve; D054928:Validation Studies as Topic; D055815:Young Adult
D008078:Cholesterol, LDL