Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver.
OBJECTIVE
To investigate the effects of a novel Leukotriene B(4) receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model.


METHODS
Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus (1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus).


RESULTS
There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more significantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls.


CONCLUSIONS
This study demonstrated that pretreatment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver ischemia-reperfusion injury.
Takeichi
Takayuki
T
Department of Transplantation and Pediatric Surgery, Postgraduate School of Medical Science, Kumamoto University, Kumamoto, Japan. ttakeichi@fc.kuh.kumamoto-u.ac.jp
Uemoto
Shinji
S
Minamiguchi
Sachiko
S
Takeyoshi
Izumi
I
Inomata
Yukihiro
Y
Tanaka
Koichi
K
Kobayashi
Eiji
E
D000818:Animals; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology*; D008297:Male; D009195:Peroxidase / Q000378:metabolism; D010666:Phenylpropionates / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew; D015427:Reperfusion Injury / Q000473:pathology / Q000517:prevention & control*; D016559:Tacrolimus / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D010666:Phenylpropionates; C067523:ONO-LB 457; D009195:Peroxidase; D016559:Tacrolimus