title: Alginate-chitosan/hydroxyapatite polyelectrolyte complex porous scaffolds: preparation and characterization.
abstract: Porous scaffolds composed of alginate (AG) and chitosan (CS) were fabricated by combining the formation of polyelectrolyte complex (PEC) with freeze-drying. The AG scaffold was used as a framework with uniformly distributed and interconnected pore structure. The chitosan or chitosan/hydroxyapatite (CS/HA) composite solution was introduced into the pores of AG scaffold to form PEC scaffolds. FT-IR, XRD and XPS analysis confirmed that CS or CS/HA was coated on the AG scaffold surface. Microstructure, porosity, mechanical strength and thermal stability of PEC scaffolds were also investigated. The AG-CS PEC scaffold and Ca2+ crosslinked AG scaffold showed smaller average pore diameter and lower porosity than those of uncrosslinked AG scaffold. Moreover, compared with Ca2+ crosslinked AG scaffold, AG-CS PEC scaffold exhibited higher mechanical strength and better thermal stability.
authors: State Key Laboratory of Chemical Resource Engineering, The Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors: Jing
authors: J
authors: Han
authors: Ziyou
authors: Z
authors: Zhou
authors: Ruixue
authors: R
authors: Yin
authors: Dongzhi
authors: D
authors: Yang
authors: Jun
authors: J
authors: Nie
mesh_terms: D000464:Alginates / Q000138:chemical synthesis* / Q000737:chemistry*; D048271:Chitosan / Q000138:chemical synthesis* / Q000737:chemistry*; D019245:Compressive Strength; D017886:Durapatite / Q000138:chemical synthesis* / Q000737:chemistry*; D004573:Electrolytes; D020723:Glucuronic Acid / Q000138:chemical synthesis / Q000737:chemistry; D006603:Hexuronic Acids / Q000138:chemical synthesis / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D056951:Photoelectron Spectroscopy; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D054457:Tissue Scaffolds / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000464:Alginates; D004573:Electrolytes; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D048271:Chitosan; D017886:Durapatite