title: Changes in stone composition according to age in Tunisian pediatric patients.
abstract: The epidemiology of renal stones has changed all over the world toward a predominance of calcium oxalate stones. However, studies evaluating the influence of age and gender on the distribution of the various types of urinary calculi are scarce. We will present the results of a study based on 205 calculi (from 122 boys and 83 girls) analyzed by infrared spectroscopy between 1993 and 2007. 90% of stones were collected by surgery, whereas only 6% by spontaneous passage. The biological exploration was performed in only 126 cases. Etiology was metabolic in 13.5%. 10.7% of stones were infectious, 13.1% were endemic and 54.9% were idiopathic. 7.8% were secondary to urinary stasis with malformation but no infection. Calcium oxalate (CaOx) was the predominant constituent in 54.7% of stones, followed by calcium phosphate and purines 14.6% in each of the cases. We found an increasing prevalence of calcium oxalate stones with age in both genders (42.9% in infant vs. 59.3% in child) (P < 0.05). Struvite stones were more frequent in infant than children. Purine stones were predominant in 20% of cases, but its prevalence decreases with age. The increase in calcium oxalate stone in school age children and the decrease in struvite and purine stones confirm the change on the etiology of urolithiasis according to age.
authors: Department of Biochemistry and Toxicology, University Hospital, 5000 Monastir, Tunisia. akram_alaya@yahoo.co.uk
authors: Akram
authors: A
authors: Alaya
authors: Mohamed F
authors: MF
authors: Najjar
authors: Abdellatif
authors: A
authors: Nouri
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002129:Calcium Oxalate / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000737:chemistry*; D017616:Magnesium Compounds / Q000032:analysis; D008297:Male; D010710:Phosphates / Q000032:analysis; D011687:Purines / Q000032:analysis; D013055:Spectrophotometry, Infrared; D000069877:Struvite; D014416:Tunisia
chemical_list: D017616:Magnesium Compounds; D010710:Phosphates; D011687:Purines; D002129:Calcium Oxalate; D000069877:Struvite; C030985:purine