title: Expression of endothelin receptor subtypes in the spiral ganglion neurons of the guinea pig.
abstract: OBJECTIVE
  Endothelin 1 has many biological activities including regulating the functions of auditory system. The present study aimed to investigate the expression of the endothelin receptors in spiral ganglion neurons and its significance in the auditory transmission.
  
  
  METHODS
  The cochleae of healthy guinea pigs were fixed, decalcified, embedded in paraffin and serially sectioned. The expression of endothelin receptor subunits, ET receptor A (ET-A) and ET receptor B (ET-B), was examined in the spiral ganglion neurons of guinea pig using immunohistochemical technique.
  
  
  RESULTS
  Different degrees of ET-A and ET-B positive reactivity appeared in all spiral ganglion neurons from the basal turn to the apical turn.
  
  
  CONCLUSIONS
  These findings support the suggestion that endothelin via the endothelin receptor may play a physiological role in the spiral ganglion neurons.
authors: Department of Otorhinolaryngology, Jinling Hospital, Clinical School of Nanjing, University, 305 East Zhongshan Road, Nanjing 210002, China.
authors: Ding-Yuan
authors: DY
authors: Xu
authors: Bo
authors: B
authors: Wu
authors: Zhe-Qin
authors: ZQ
authors: Li
authors: Qiu-Ping
authors: QP
authors: Wang
authors: Yong
authors: Y
authors: Zhang
authors: Fei
authors: F
authors: Xue
authors: Jun-Feng
authors: JF
authors: Ji
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D001306:Auditory Pathways / Q000166:cytology / Q000378:metabolism*; D019332:Endothelin-1 / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D007150:Immunohistochemistry; D008297:Male; D021381:Protein Transport; D044022:Receptor, Endothelin A / Q000276:immunology / Q000378:metabolism*; D044023:Receptor, Endothelin B / Q000276:immunology / Q000378:metabolism; D013136:Spiral Ganglion / Q000166:cytology / Q000378:metabolism*; D014132:Trachea / Q000166:cytology / Q000276:immunology / Q000378:metabolism
chemical_list: D000888:Antibodies, Anti-Idiotypic; D019332:Endothelin-1; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B