title: Optimization of antitachycardia pacing protocols applied to atrial fibrillation: insights from a biophysical model.
abstract: We present a model-based systematic study of antitachycardia pacing protocols applied to atrial fibrillation, focusing on the ability to achieve and maintain capture during pacing, as a function of both pacing site and period. We observed that pacing sites located away from anatomical obstacles led to faster and more robust capture. Moreover, after comparing burst and ramp pacing, our results indicate that in order to get capture it is necessary to pace at a fixed optimal period over a sufficient long time.
authors: Signal Processing Laboratory of the Swiss Federal Institute of Technology, 1015 Lausanne, Switzerland. laurent.uldry@epfl.ch
authors: Laurent
authors: L
authors: Uldry
authors: Nathalie
authors: N
authors: Virag
authors: Lukas
authors: L
authors: Kappenberger
authors: Jean-Marc
authors: JM
authors: Vesin
mesh_terms: D000465:Algorithms; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001281:Atrial Fibrillation / Q000503:physiopathology* / Q000628:therapy; D001698:Biomedical Engineering / Q000379:methods; D001703:Biophysics / Q000379:methods*; D002304:Cardiac Pacing, Artificial / Q000379:methods; D003198:Computer Simulation; D004594:Electrophysiology / Q000379:methods; D004867:Equipment Design; D006801:Humans; D007700:Kinetics; D008279:Magnetic Resonance Imaging / Q000379:methods; D010138:Pacemaker, Artificial; D013610:Tachycardia / Q000628:therapy*
chemical_list: D000889:Anti-Arrhythmia Agents