title: Toward cell therapy using placenta-derived cells: disease mechanisms, cell biology, preclinical studies, and regulatory aspects at the round table.
abstract: Among the many cell types that may prove useful to regenerative medicine, mounting evidence suggests that human term placenta-derived cells will join the list of significant contributors. In making new cell therapy-based strategies a clinical reality, it is fundamental that no a priori claims are made regarding which cell source is preferable for a particular therapeutic application. Rather, ongoing comparisons of the potentiality and characteristics of cells from different sources should be made to promote constant improvement in cell therapies, and such comparisons will likely show that individually tailored cells can address disease-specific clinical needs. The principle underlying such an approach is resistance to the notion that comprehensive characterization of any cell type has been achieved, neither in terms of phenotype nor risks-to-benefits ratio. Tailoring cell therapy approaches to specific conditions also requires an understanding of basic disease mechanisms and close collaboration between translational researchers and clinicians, to identify current needs and shortcomings in existing treatments. To this end, the international workshop entitled "Placenta-derived stem cells for treatment of inflammatory diseases: moving toward clinical application" was held in Brescia, Italy, in March 2009, and aimed to harness an understanding of basic inflammatory mechanisms inherent in human diseases with updated findings regarding biological and therapeutic properties of human placenta-derived cells, with particular emphasis on their potential for treating inflammatory diseases. Finally, steps required to allow their future clinical application according to regulatory aspects including good manufacturing practice (GMP) were also considered. In September 2009, the International Placenta Stem Cell Society (IPLASS) was founded to help strengthen the research network in this field.
authors: Centro di Ricerca E. Menni, Brescia, Italy. ornella.parolini@tin.it
authors: Ornella
authors: O
authors: Parolini
authors: Francesco
authors: F
authors: Alviano
authors: Irene
authors: I
authors: Bergwerf
authors: Diana
authors: D
authors: Boraschi
authors: Cosimo
authors: C
authors: De Bari
authors: Peter
authors: P
authors: De Waele
authors: Massimo
authors: M
authors: Dominici
authors: Marco
authors: M
authors: Evangelista
authors: Werner
authors: W
authors: Falk
authors: Simone
authors: S
authors: Hennerbichler
authors: David C
authors: DC
authors: Hess
authors: Giacomo
authors: G
authors: Lanzoni
authors: Bing
authors: B
authors: Liu
authors: Fabio
authors: F
authors: Marongiu
authors: Colin
authors: C
authors: McGuckin
authors: Stefan
authors: S
authors: Mohr
authors: Maria Luisa
authors: ML
authors: Nolli
authors: Racheli
authors: R
authors: Ofir
authors: Peter
authors: P
authors: Ponsaerts
authors: Luca
authors: L
authors: Romagnoli
authors: Abraham
authors: A
authors: Solomon
authors: Maddalena
authors: M
authors: Soncini
authors: Stephen
authors: S
authors: Strom
authors: Daniel
authors: D
authors: Surbek
authors: Sankar
authors: S
authors: Venkatachalam
authors: Susanne
authors: S
authors: Wolbank
authors: Steffen
authors: S
authors: Zeisberger
authors: Andy
authors: A
authors: Zeitlin
authors: Andreas
authors: A
authors: Zisch
authors: Cesar V
authors: CV
authors: Borlongan
mesh_terms: D000818:Animals; D002469:Cell Separation / Q000379:methods; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000628:therapy; D010920:Placenta / Q000166:cytology*; D011247:Pregnancy; D013234:Stem Cells / Q000166:cytology* / Q000276:immunology