Diagnostic imaging of esophageal epithelium with clinical endoscopic polarized scanning spectroscopy instrument.
This letter reports the development of an endoscopic polarized scanning spectroscopy (EPSS) instrument compatible with existing endoscopes. This instrument uses light scattering spectroscopy (LSS). In proof-of-principle studies using a single-point instrument, LSS has successfully demonstrated the ability to identify pre-cancer in the epithelial tissues of five different organs, including Barrett's esophagus (BE). The EPSS instrument can provide real time in vivo information on the location of otherwise invisible high grade dysplasia (HGD), a predictor of adenocarcinoma, and thus can serve as a guide for biopsy. It should greatly reduce the time and labor involved in performing screening and obtaining diagnoses, cause less patient discomfort and ensure that fewer biopsies are required for the reliable location of pre-cancerous lesions.
Qiu
Le
L
Department of Obgyn and Reproductive Biology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA.
Chuttani
Ram
R
Zhang
Songhua
S
Feng
Jun
J
Itani
Sara
S
Fang
Hui
H
Pleskow
Douglas
D
Sawhney
Mandeep S
MS
Salahuddin
Saira
S
Modell
Mark D
MD
Vitkin
Edward
E
Hanlon
Eugene B
EB
Itzkan
Irving
I
Perelman
Lev T
LT
D001471:Barrett Esophagus / Q000473:pathology*; D001706:Biopsy; D003952:Diagnostic Imaging; D004847:Epithelial Cells / Q000473:pathology; D004867:Equipment Design; D004938:Esophageal Neoplasms / Q000473:pathology*; D004945:Esophagoscopy / Q000379:methods*; D005336:Fiber Optic Technology; D006801:Humans; D008859:Microscopy, Polarization / Q000295:instrumentation / Q000379:methods*; D015203:Reproducibility of Results; D013057:Spectrum Analysis / Q000379:methods