[First line chemotherapy of advanced epithelial ovarian cancer].
The treatment of the advanced ovarian adenocarcinoma, most frequently stage at diagnostic, relies on association of surgery and chemotherapy. The current standard is the association carboplatine-paclitaxel. In spite of this treatment, relapses are frequent, and the prognosis thus remains very reserved. Presently the current areas of research aim at both improving the efficiency of treatments and decreasing their toxicity. So the various trials dealt with the use of the other cytotoxics having proved efficiency against relapses either in double-agent therapy or in association in the current standard, or in the administration of the chemotherapy by intra peritoneal way. They also investigated the possibility of pursuing the therapeutic sequence by a treatment of maintenance or consolidation. As for numerous cancerous pathologies, the targeted therapies, notably the antiangiogenic one, represent an important hope in the treatment of the ovarian cancer.
Lhommé
C
C
Institut Gustave-Roussy, Comité de Gynécologie, 39 Rue Camille-Desmoulins, 94805 Villejuif, France. lhomme@igr.fr
Even
C
C
Morice
P
P
Balleyguier
C
C
Petrella
Mc
M
Gouy
S
S
Uzan
C
C
Duvillard
P
P
Pautier
P
P
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous / Q000592:standards; D007263:Infusions, Parenteral / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control / Q000601:surgery; D017239:Paclitaxel / Q000008:administration & dosage; D017410:Practice Guidelines as Topic
D016190:Carboplatin; D017239:Paclitaxel