Increased tibiofemoral cartilage contact deformation in patients with anterior cruciate ligament deficiency.
OBJECTIVE
To investigate the in vivo cartilage contact biomechanics of the tibiofemoral joint following anterior cruciate ligament (ACL) injury.


METHODS
Eight patients with an isolated ACL injury in 1 knee, with the contralateral side intact, participated in the study. Both knees were imaged using a specific magnetic resonance sequence to create 3-dimensional models of knee bone and cartilage. Next, each patient performed a lunge motion from 0 degrees to 90 degrees of flexion as images were recorded with a dual fluoroscopic system. The three-dimensional knee models and fluoroscopic images were used to reproduce the in vivo knee position at each flexion angle. With this series of knee models, the location of the tibiofemoral cartilage contact, size of the contact area, cartilage thickness at the contact area, and magnitude of the cartilage contact deformation were compared between intact and ACL-deficient knees.


RESULTS
Rupture of the ACL changed the cartilage contact biomechanics between 0 degrees and 60 degrees of flexion in the medial compartment of the knee. Compared with the contralateral knee, the location of peak cartilage contact deformation on the tibial plateaus was more posterior and lateral, the contact area was smaller, the average cartilage thickness at the tibial cartilage contact area was thinner, and the resultant magnitude of cartilage contact deformation was increased. Similar changes were observed in the lateral compartment, with increased cartilage contact deformation from 0 degrees to 30 degrees of knee flexion in the presence of ACL deficiency.


CONCLUSIONS
ACL deficiency alters the in vivo cartilage contact biomechanics by shifting the contact location to smaller regions of thinner cartilage and by increasing the magnitude of the cartilage contact deformation.
Van de Velde
Samuel K
SK
Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114, USA.
Bingham
Jeffrey T
JT
Hosseini
Ali
A
Kozanek
Michal
M
DeFrate
Louis E
LE
Gill
Thomas J
TJ
Li
Guoan
G
D000328:Adult; D016118:Anterior Cruciate Ligament / Q000473:pathology* / Q000503:physiopathology; D000070598:Anterior Cruciate Ligament Injuries; D001696:Biomechanical Phenomena; D005080:Exercise Test; D005260:Female; D005269:Femur / Q000473:pathology / Q000503:physiopathology; D005471:Fluoroscopy; D006801:Humans; D007718:Knee Injuries / Q000473:pathology* / Q000503:physiopathology; D007719:Knee Joint / Q000473:pathology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D013977:Tibia / Q000473:pathology / Q000503:physiopathology; D016474:Weight-Bearing; D055815:Young Adult