title: [Multicenter report of nonmyeloablative allogeneic stem cell transplantation for hematologic diseases].
abstract: OBJECTIVE
  To observe the treatment effect and toxicity of nonmyeloablative allogeneic stem cell transplantation (NST) for hematologic diseases.
  
  
  METHODS
  A total of 243 hematologic diseases patients received HLA-identical NST were enrolled in this study from 9 transplant centers of NST Cooperative Group in China. Nonmyeloablative conditioning regimen was based on fludarabine (Flud), rabbit anti-human thymocyte globulin (ATG), cyclophosphamide (CTX) (FAC), and plus cytarabine or busulfan (BU) etc. Graft-versus-host disease (GVHD) prophylaxis included cyclosporin A (CsA) and mycophenolate mofetil (MMF).
  
  
  RESULTS
  Among the 243 patients, 219 (90.1%) achieved full donor chimerism (FDC), 2(0.8%) engraftment failure. 78 (32.1%) had mixture chimerism (MC) at 4 weeks after NST, out of which 56 switched to FDC, 16 remained MC and 6 (2.5%) developed graft rejection. The incidence of acute GVHD was 34.2%, including 6.6% of grade III-IV acute GVHD. Chronic GVHD developed in 78 (32.1%) patients. The follow-up durations were 3 - 99 months, 162 (66.7%) were still alive and the overall survival rates were 76.5%, 73.9%, 70.7%, and 27.8% for MDS/SAA, chronic myeloid leukemia, acute leukemia at first remission, and refractory or relapsed leukemia, respectively.
  
  
  CONCLUSIONS
  The nonmyeloablative allogeneic stem cell transplantation based on FAC conditioning results in sustained engraftment and mild aGVHD, providing a new feasible curative therapy for hematology diseases.
authors: Department of Hematology and Transplantation, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100085, China.
authors: Hui-sheng
authors: HS
authors: Ai
authors: Xiao-jun
authors: XJ
authors: Huang
authors: Zhen-hua
authors: ZH
authors: Qiao
authors: Jian-min
authors: JM
authors: Wang
authors: Bao-an
authors: BA
authors: Chen
authors: Hai
authors: H
authors: Bai
authors: Bao-fu
authors: BF
authors: Shi
authors: Ying-min
authors: YM
authors: Liang
authors: Wan-jun
authors: WJ
authors: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002681:China; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D006402:Hematologic Diseases / Q000601:surgery*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult