title: Comparison of cytogenetic changes between primary and relapsed patients with borderline tumors of the ovary.
abstract: The aim of this work was to compare cytogenetic changes in primary and relapsed borderline tumors of the ovary. We analyzed 11 tumors (6 primary and 5 relapsed) by conventional GTG banding analysis and fluorescence in situ hybridization. The tumors studied were clinical stages I and III. Genomic imbalances were detected in both investigated groups. In the primary tumors group, only simple chromosome changes were detected. There were gains of chromosome 12, 7, and 8. The presence of additional copies of chromosomes 12 and 7 was independent of histologic subtype, whereas trisomy 8 appeared only in serous tumors. In the group of relapsed borderline tumors, besides trisomies 7 and 12, the structural aberrations of chromosomes 1, 6q, 7q, and 10q were revealed. Gains of tested oncogenes (CCND1 and MYC) have been demonstrated in both groups of investigated tumors. Gains of CCNC1 and MYC genes could be of prognostic value in borderline tumors, but this assumption requires further research.
authors: Cytogenetic Laboratory, Maria Sklodowska-Curie Memorial Cancer Centre and Institute, ul. Roentgena 5, 02-781 Warsaw, Poland. bgrygal@coi.waw.pl
authors: Beata
authors: B
authors: Grygalewicz
authors: Piotr
authors: P
authors: Sobiczewski
authors: Paulina
authors: P
authors: Krawczyk
authors: Renata
authors: R
authors: Woroniecka
authors: Jolanta
authors: J
authors: Rygier
authors: Anna
authors: A
authors: Pastwińska
authors: Mariusz
authors: M
authors: Bidziński
authors: Barbara
authors: B
authors: Pieńkowska-Grela
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002877:Chromosomes, Human; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D012008:Recurrence; D055815:Young Adult