[Noninvasive prenatal diagnosis from maternal plasma in serological conflicts in Poland: current practice and future prospects].
The principles and results of noninvasive prenatal diagnosis in serological conflicts in Poland were described in the following work. Noninvasive fetal genotyping from plasma of immunized mother identifies women carrying fetus without incompatible antigen and risk of hemolytic disease. The presence of fetal RHD gene or RHCE*c/E alleles in maternal plasma is examined routinely in Institute of Hematology and Blood Transfusion in Warsaw. Preliminary results of successful fetal KEL*1 genotyping from maternal blood were obtained.
Orzińska
Agnieszka
A
Zakład immunologii Hematologicznej i Transfuzjologicznej, Instytut Hematologii i Transfuzjologii w Warszawie. orzinska@ihit.waw.pl
Guz
Katarzyna
K
Brojer
Ewa
E
D000046:Academic Medical Centers; D000328:Adult; D001788:Blood Grouping and Crossmatching / Q000379:methods* / Q000639:trends; D004247:DNA / Q000097:blood; D004899:Erythroblastosis, Fetal / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D011044:Poland; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D015203:Reproducibility of Results; D012203:Rh Isoimmunization / Q000097:blood / Q000175:diagnosis*; D012204:Rh-Hr Blood-Group System / Q000235:genetics*; D012680:Sensitivity and Specificity
D012204:Rh-Hr Blood-Group System; C026410:Rho(D) antigen; D004247:DNA