Gastroprotective flavonoid constituents from Oroxylum indicum Vent.
Chemical investigation of the stem bark of Oroxylum indicum resulted in the isolation and characterization of two new flavonoid glycosides (1, 2), along with seven known compounds (3-9). Their structures were established on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by the comparison with spectroscopic data reported in the literature. In addition, all the compounds were tested for their ulcer protective effects against various gastric ulceritis inducing models in rats.
Hari Babu
T
T
Natural Products Laboratory, Organic Division-I, Indian Institute of Chemical Technology, Hyderabad 500 607, India.
Manjulatha
K
K
Suresh Kumar
G
G
Hymavathi
A
A
Tiwari
Ashok K
AK
Purohit
Muraleedhar
M
Madhusudana Rao
J
J
Suresh Babu
K
K
D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D029402:Bignoniaceae / Q000737:chemistry*; D004195:Disease Models, Animal; D044950:Flavanones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D051381:Rats
D000897:Anti-Ulcer Agents; D044950:Flavanones; D047309:Flavones; D005419:Flavonoids