Can statin be a novel pharmacophore for antidiabetic activity?
Currently, statins are in lime light due to their pleiotropic effects. One of their pleiotropic effects is on glucose metabolism. Various clinical and preclinical studies were designed to evaluate statins' effect on glucose metabolism. This review describes preclinical and clinical evidences of statins' action on glucose metabolism.
Parmar
S A
SA
L. M. College of Pharmacy, Ahmedabad, India- 380061.
Mehta
A A
AA
D000924:Anticholesteremic Agents / Q000737:chemistry* / Q000494:pharmacology; D003920:Diabetes Mellitus / Q000188:drug therapy; D005947:Glucose / Q000378:metabolism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology; D007333:Insulin Resistance; D012995:Solubility
D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007004:Hypoglycemic Agents; D005947:Glucose