[Retrospective cohort study on the rate of mother-to-child transmission among mothers infected with human immunodeficiency virus type 1 through blood transfusion].
OBJECTIVE
To study the rate of mother-to-child transmission (MTCT) on HIV-1.


METHODS
All local residents from 8 townships in a region were screened for mothers who had a history of only one blood transfusion and 63 were found HIV-1 positive. A further study on these HIV-1 positive mothers and their children was conducted with the emphasis on the date of receiving blood transfusion, date and type of nationality, history regarding breastfeeding and so on. Sera specimens from 84 children born from 63 HIV-1 positive mothers were screened, using ELISA for HIV-1 antibody, and positive specimens were confirmed by Western-blot.


RESULTS
The rate of MTCT was 32.1% (27/84) for children with all risk factors related to MTCT. Another 36.8% (7/19) were related to factors on intrauterine, intrapartum and breastfeeding, 35.7% (5/14) to intrapartum and breastfeeding factors, 14.3% (2/14) to intrauterine and intrapartum factors, 37.9% (11/29) to breastfeeding factor alone. By group combination analysis, the MTCT rate was 36.9% (24/65) with breastfeeding, 11.8% (2/17) with artificial feeding, and the former was significantly higher than the latter.


CONCLUSIONS
HIV-1 MTCT rate among mothers caused by a single blood transfusion varied with different risk factors. Breastfeeding played an important role in MTCT, appeared in our study.
Chen
Su-Liang
SL
Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, China. chensuliang@sina.com
Zhao
Hong-Ru
HR
Li
Xiao-Mei
XM
Zhang
Yu-Qi
YQ
Jin
Guang-Sheng
GS
Zhao
Cui-Ying
CY
Zhang
Yan-Ping
YP
Bai
Guang-Yi
GY
Li
Bao-Jun
BJ
Liang
Liang
L
Chen
Zhi-Qiang
ZQ
Hui
Yan-Liang
YL
Liu
Fu-Bao
FB
Xu
Zhi-Xian
ZX
Zhu
Jian-Guo
JG
Mao
Yu-Rong
YR
D000914:Antibodies, Viral / Q000097:blood; D015153:Blotting, Western; D001942:Breast Feeding / Q000009:adverse effects; D002648:Child; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission*; D015528:HIV Seroprevalence; D015497:HIV-1 / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D012189:Retrospective Studies; D012307:Risk Factors; D065227:Transfusion Reaction
D000914:Antibodies, Viral