title: Relationship between renal resistive index and inflammation in untreated hypertensive patients.
abstract: The aim of this study was to evaluate the relationship between renal resistive index and inflammation in untreated hypertensive patients. Sixty-one hypertensive patients (male/female: 38/23, aged 45.8 +/- 8.3 years, and mean hypertension duration 28.2 +/- 35.6 months) and 40 (male/female: 23/17, aged 42.7 +/- 8.5 years) healthy control subjects were included in the study. Renal resistive index was positively correlated with age (P = 0.016, r = 0.308), pulse pressure (P = 0.022, r = 0.294), C-reactive protein (P = 0.00, r = 0.757), urinary albumin excretion (P = 0.003, r = 0.371) and negatively correlated with creatinine clearance (P = 0.042, r = -0.262) in the hypertensive group. The hypertensive group was further divided in two groups according to the renal resistive index; < 0.60 and > 0.60. In the > 0.60 group, age (48.0 +/- 7.3 versus 42.8 +/- 8.9 years, P = 0.01) and C-reactive protein levels (7.4 +/- 1.5 versus 4.0 +/- 1.6 mg/L, P = 0.01) were higher, and creatinine clearance (95.5 +/- 22.1 versus 109.1 +/- 25.3 mL/min, P = 0.04) was lower than the < 0.60 group. Renal resistive index was higher in the nondippers than the dippers (0.61 +/- 0.04 versus 0.58 +/- 0.03, P = 0.003). Renal resistive index is associated with inflammation and may be a useful marker, together with albuminuria, in hypertensive patients when evaluating hypertensive renal damage.
authors: Department of Nephrology, Baskent University Faculty of Medicine, Adana Teaching and Medical Research Center, Yuregir, Ankara, Turkey.
authors: Ruya
authors: R
authors: Ozelsancak
authors: Dilek
authors: D
authors: Torun
authors: Zafer
authors: Z
authors: Koc
authors: Siren
authors: S
authors: Sezer
authors: Fatma Nurhan
authors: FN
authors: Ozdemir
authors: Emin Alp
authors: EA
authors: Niron
mesh_terms: D000367:Age Factors; D000419:Albuminuria / Q000652:urine; D002097:C-Reactive Protein / Q000032:analysis; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D011674:Pulse; D012077:Renal Artery / Q000502:physiology*
chemical_list: D002097:C-Reactive Protein; D003404:Creatinine