title: Enantioselective synthesis of functionalized fluorinated cyclohexenones via robinson annulation catalyzed by primary-secondary diamines.
abstract: Primary-secondary diamine catalysts were used to catalyze the asymmetric Robinson annulation to synthesize multiply substituted fluorinated chiral cyclohexenones with two contiguous stereogenic centers, one of which is a fluorinated quaternary chiral center, with excellent enantioselectivities and diastereoselectivities in moderate to good yields.
authors: Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, 345 Lingling Lu, Shanghai 200032, China.
authors: Hai-Feng
authors: HF
authors: Cui
authors: Ying-Quan
authors: YQ
authors: Yang
authors: Zhuo
authors: Z
authors: Chai
authors: Peng
authors: P
authors: Li
authors: Chang-Wu
authors: CW
authors: Zheng
authors: Shi-Zheng
authors: SZ
authors: Zhu
authors: Gang
authors: G
authors: Zhao
mesh_terms: D002384:Catalysis; D003512:Cyclohexanones / Q000138:chemical synthesis* / Q000737:chemistry; D003959:Diamines / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D013237:Stereoisomerism
chemical_list: D003512:Cyclohexanones; D003959:Diamines; D006845:Hydrocarbons, Fluorinated