Drug delivery from ordered mesoporous matrices.
Research interest in silica-based ordered mesoporous materials (SMMs) as drug delivery systems has grown drastically in the last few years owing to the great versatility and stability of these mesoporous matrices. This review aims to resume the work carried out in this area so far and the possible applications in biomedical technologies. The different SMMs can be designed and tailored using different chemical strategies according to the drug and clinical necessity. The available channels of SMMs that can be used to store drugs can be opened and closed by different systems, in the so-called stimuli-responsive release devices. These systems could improve the therapeutic efficacy compared with conventional sustained release systems. SMMs offer such a great versatility that can be used both for oral and for local drug delivery, with huge possible applications in different clinical areas.
Manzano
Miguel
M
Universidad Complutense de Madrid, Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, E-28040-Madrid, Spain.
Colilla
Montserrat
M
Vallet-Regí
María
M
D000818:Animals; D020811:Biomedical Technology / Q000379:methods; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D008280:Magnetics; D053758:Nanoparticles; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D012822:Silicon Dioxide