Ureide catabolism in Arabidopsis thaliana and Escherichia coli.
The availability of whole genome sequences boosts the identification of biochemical pathways conserved across species using tools of comparative genomics. A cross-organism protein association analysis allowed us to identify two enzymes, ureidoglycine aminohydrolase and ureidoglycolate amidohydrolase, that catalyze the final reactions of purine degradation in the model plant Arabidopsis thaliana. A similar pathway was found in Escherichia coli, while an alternative metabolic route via ureidoglycine transaminase can be predicted for other organisms.
Werner
Andrea K
AK
Freie Universität Berlin, Institut für Biologie, Abteilung Biochemie der Pflanzen, Berlin, Germany.
Romeis
Tina
T
Witte
Claus-Peter
CP
D000481:Allantoin / Q000737:chemistry; D019760:Amidine-Lyases / Q000737:chemistry*; D000619:Aminohydrolases / Q000737:chemistry*; D017360:Arabidopsis / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000737:chemistry*; D002384:Catalysis; D030562:Databases, Protein; D004926:Escherichia coli / Q000378:metabolism*; D023281:Genomics; D008190:Lyases / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008954:Models, Biological; D009584:Nitrogen / Q000737:chemistry; D040901:Proteomics / Q000379:methods; D012984:Software; D013045:Species Specificity
D029681:Arabidopsis Proteins; D000481:Allantoin; D000619:Aminohydrolases; C546345:ureidoglycine aminohydrolase, Arabidopsis; D008190:Lyases; D019760:Amidine-Lyases; C033757:ureidoglycollate lyase; D009584:Nitrogen