title: Pyridine containing M(1) positive allosteric modulators with reduced plasma protein binding.
abstract: Incorporation of pyridines and diazines into the biphenyl region of quinolone carboxylic acid derived M(1) positive allosteric modulators was investigated as a means of lowering plasma protein binding to enhance CNS exposure.
authors: Department of Medicinal Chemistry, Merck Research Laboratories, Sumneytown Pike, PO Box 4, West Point, PA 19486, USA. scott_d_kuduk@merck.com
authors: Scott D
authors: SD
authors: Kuduk
authors: Christina N
authors: CN
authors: Di Marco
authors: Victoria
authors: V
authors: Cofre
authors: Daniel R
authors: DR
authors: Pitts
authors: William J
authors: WJ
authors: Ray
authors: Lei
authors: L
authors: Ma
authors: Marion
authors: M
authors: Wittmann
authors: Matthew A
authors: MA
authors: Seager
authors: Matthew
authors: M
authors: Seager
authors: Kenneth
authors: K
authors: Koeplinger
authors: Chuck D
authors: CD
authors: Thompson
authors: George D
authors: GD
authors: Hartman
authors: Mark T
authors: MT
authors: Bilodeau
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000494:Allosteric Regulation; D000818:Animals; D001798:Blood Proteins / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D011485:Protein Binding; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D043643:Receptor, Muscarinic M1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D001798:Blood Proteins; D011725:Pyridines; D043643:Receptor, Muscarinic M1