[Intracerebral infiltration by monoclonal plasmacytoid cells in Waldenstrom's macroglobulinemia: a case report and review of the literature].
OBJECTIVE
To sum up the clinical experience of the diagnosis and treatment of intracerebral infiltration by monoclonal plasmacytoid cells in Waldenstrom's macroglobulinemia(Bing-Neel syndrome).


METHODS
The clinical data of the diagnosis and treatment of a case of Bing-Neel syndrome was analyzed.


RESULTS
A 56-year-old male was diagnosed as Waldenstrom's macroglobulinemia one year ago, and presented with persistent headache during the treatment period. Magnetic resonance imaging showed a high intensity area on T2-weighed images in the right frontal lobe which was well enhanced by gadolinium-diethylenetriaminepenta-acetic acid. Infiltration of neoplastic cells was confirmed by biopsy. Immunohistochemical examination showed that mature plasmacytoid cells in the cerebral parenchyma were immunoglobulin M positive.


CONCLUSIONS
Infiltration in CNS (Bing-Neel syndrome) is uncommon in Waldenstrom's macroglobulinemia. As there is no effective therapy for this Bing-Neel syndrome, combination of radiation and chemotherapy should be considered for this situation.
Li
Jie-Ping
JP
Department of Hematology, Xinqiao Hospital, Third Military University, Chongqing 400037, China.
Yin
Xiao-Lin
XL
Kong
Pei-Yan
PY
Chen
Xing-Hua
XH
Zeng
Dong-Feng
DF
Xiang
Xi-Xi
XX
Peng
Xian-Gui
XG
D001921:Brain / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D008258:Waldenstrom Macroglobulinemia / Q000473:pathology*