Baseline plasma glycemic profiles but not inflammatory biomarkers predict symptomatic restenosis after angioplasty of arteriovenous fistulas in patients with hemodialysis.
OBJECTIVE
The aim of the study was to evaluate the role of atherosclerosis risk factors and baseline inflammatory status in the development of restenosis after successful percutaneous transluminal angioplasty (PTA) of hemodialysis arteriovenous (AV) fistulas.


METHODS
We obtained baseline plasma biochemistry and inflammatory markers in 140 patients with dysfunctional AV fistulas before the PTA procedures. Patients were followed clinically for 6 months.


RESULTS
There was no significant difference in the baseline inflammatory markers between the restenosis and patency group. The Kaplan-Meier analysis showed that non-diabetic patients had higher patency rate than diabetic patients (69% vs. 48%, p=0.02) and diabetic patients with optimal glycemic control had higher patency rate than patients with suboptimal glycemic control (61% vs. 30%, p=0.01).


CONCLUSIONS
The presence of diabetes mellitus predicted restenosis of AV fistulas after PTA and optimal blood glucose control might be critical to the patency after PTA.
Wu
Chih-Cheng
CC
Department of Medicine, Hsinchu General Hospital, Hsinchu, Taiwan, ROC.
Wen
Szu-Chi
SC
Yang
Chung-Wei
CW
Pu
Shih-Yun
SY
Tsai
Kuei-Chin
KC
Chen
Jaw-Wen
JW
D000368:Aged; D000800:Angioplasty, Balloon / Q000009:adverse effects; D001166:Arteriovenous Shunt, Surgical / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000601:surgery; D005260:Female; D006083:Graft Occlusion, Vascular / Q000209:etiology*; D006801:Humans; D007249:Inflammation / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects; D014654:Vascular Patency
D015415:Biomarkers; D001786:Blood Glucose