Live birth after polar body array comparative genomic hybridization prediction of embryo ploidy-the future of IVF?
OBJECTIVE
To ascertain meiotic aneuploidy of the human egg using array comparative genomic hybridization to evaluate the 23-paired chromosome copy number of first polar body as an objective prognosticator of embryo viability for embryo transfer in the same cycle.


METHODS
Case report.


METHODS
Independent-sector IVF program.


METHODS
A 41-year-old woman with a history of 13 failed cycles of IVF.


METHODS
Polar body biopsy of metaphase II eggs.


METHODS
Birth.


RESULTS
Two of the nine eggs were euploid, and the resulting embryos, although morphologically inferior to sibling embryos, were selected for transfer to the uterus, resulting in the birth of a normal healthy baby.


CONCLUSIONS
Selection of euploid eggs, as an objective parameter of subsequent embryo viability and with the opportunity to transfer embryos in the same cycle could maximise the opportunity for live birth after IVF even in cases with poor prognosis.
Fishel
Simon
S
CARE Fertility, John Webster House, 6 Lawrence Drive, Nottingham Business Park, Nottingham NG8 6PZ, United Kingdom. simon.fishel@carefertility.com
Gordon
Anthony
A
Lynch
Colleen
C
Dowell
Ken
K
Ndukwe
George
G
Kelada
Ehab
E
Thornton
Simon
S
Jenner
Lucy
L
Cater
Ellen
E
Brown
Anthony
A
Garcia-Bernardo
Jose
J
D000328:Adult; D001706:Biopsy; D055028:Comparative Genomic Hybridization; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000639:trends*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D050498:Live Birth; D008297:Male; D011003:Ploidies; D011237:Predictive Value of Tests; D019836:Preimplantation Diagnosis / Q000639:trends*