title: N-methyl-D-aspartate receptor antibodies in pediatric dyskinetic encephalitis lethargica.
abstract: Encephalitis lethargica (EL) describes an encephalitis with psychiatric, sleep, and extrapyramidal movement disorders. Dyskinetic and parkinsonian forms have been described. EL shares clinical features with the anti-N-methyl-D-aspartate receptor (NMDAR-Ab) encephalitis. We studied 20 sera from pediatric patients with contemporary EL. Ten sera (from 2 males and 8 females, aged 1.3-13 years) and 6/6 cerebrospinal fluid samples were positive for NMDAR-Ab. NMDAR-Ab-positive patients had dyskinesias, agitation, seizures, and insomnia, whereas parkinsonism and somnolence dominated in the NMDAR-Ab-negative children. We were unable to identify any tumors. The dyskinetic form of EL is an NMDAR-Ab encephalitis and can affect very young children.
authors: Neuroinflammation Group, Institute for Neuroscience and Muscle Research, the Kids Research Institute at the Children's Hospital at Westmead, University of Sydney, Westmead, Australia.
authors: Russell C
authors: RC
authors: Dale
authors: Sarosh R
authors: SR
authors: Irani
authors: Fabienne
authors: F
authors: Brilot
authors: Sekhar
authors: S
authors: Pillai
authors: Richard
authors: R
authors: Webster
authors: Deepak
authors: D
authors: Gill
authors: Bethan
authors: B
authors: Lang
authors: Angela
authors: A
authors: Vincent
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000096:biosynthesis* / Q000378:metabolism; D001666:Binding Sites, Antibody; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009474:Neurons / Q000276:immunology; D010301:Parkinson Disease, Postencephalitic / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000276:immunology*; D010641:Phenotype; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology* / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D024642:Potassium Channels, Voltage-Gated; D016194:Receptors, N-Methyl-D-Aspartate