title: A personalized and optimal approach for dosing contrast material at coronary computed tomography angiography.
abstract: A method for constructing a personalized contrast medium protocol at contrast enhanced, Coronary CT Angiography (CCTA) is presented. A one compartment pharmacokinetic model is parameterized and identified with a minimal data set from a test-bolus injection. A direct-search optimization is performed to construct a protocol that achieves target enhancement in the cardiac structures. Clinical results demonstrating the method's ability to achieve prospectively chosen image enhancement levels while reducing contrast medium dose are presented.
authors: MEDRAD Inc, Indianola, PA 15051, USA. jkalafut@medrad.com
authors: John F
authors: JF
authors: Kalafut
authors: Corey A
authors: CA
authors: Kemper
authors: Pal
authors: P
authors: Suryani
authors: U
authors: U
authors: Schoepf
mesh_terms: D000465:Algorithms; D000792:Angiography / Q000379:methods*; D001011:Aorta / Q000473:pathology; D003287:Contrast Media / Q000494:pharmacology*; D017023:Coronary Angiography / Q000295:instrumentation* / Q000379:methods; D006321:Heart / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007455:Iodine / Q000493:pharmacokinetics; D015233:Models, Statistical; D010599:Pharmacokinetics; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D007455:Iodine