title: Tumor doubling time in two cases of main duct intraductal papillary-mucinous neoplasms of the pancreas.
abstract: The present study reports the growth rate in two cases of main duct pancreatic intraductal papillary-mucinous neoplasms (MD-IPMNs) demonstrating significant changes over several years' observation. The first patient was a 74-year-old woman with an incidental finding of diffuse dilatation of the main pancreatic duct (MPD). Endoscopic retrograde pancreatography (ERP) identified a 5 mm filling defect. Three years later computed tomography (CT) revealed a 20 mm mass occupying the MPD. The second patient was a 67-year-old woman who presented with back pain. Abdominal CT revealed a 5 mm mass in the dilated MPD. Five years later, CT and ERP showed a 20 mm mass occupying the markedly dilated MPD. Both patients subsequently underwent pancreatectomy. Histologically, the tumors showed an intraductal papillary growth occupying the dilated MPD and comprised of mucin-containing columnar epithelial cells. The tumor volume doubling time of these MD-IPMNs was 141 and 304 days in patient 1 and 2, respectively, with a mean of 222.5 days. The present reports demonstrate the ability of benign MD-IPMNs to grow at a significant rate, supporting the current consensus guidelines that MD-IPMNs require surgical resection.
authors: Department of General Medicine, Asahikawa Medical College, Asahikawa, Japan. tanno1se@asahikawa-med.ac.jp
authors: Satoshi
authors: S
authors: Tanno
authors: Junpei
authors: J
authors: Sasajima
authors: Kazuya
authors: K
authors: Koizumi
authors: Nobuyuki
authors: N
authors: Yanagawa
authors: Yasuhiro
authors: Y
authors: Nakano
authors: Manabu
authors: M
authors: Osanai
authors: Yusuke
authors: Y
authors: Mizukami
authors: Tsuneshi
authors: T
authors: Fujii
authors: Takeshi
authors: T
authors: Obara
authors: Toshikatsu
authors: T
authors: Okumura
authors: Yutaka
authors: Y
authors: Kohgo
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology*; D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000473:pathology; D002291:Carcinoma, Papillary / Q000473:pathology*; D005260:Female; D006801:Humans; D010183:Pancreatic Ducts; D010190:Pancreatic Neoplasms / Q000473:pathology*; D013997:Time Factors