Exercise and insulin: Convergence or divergence at AS160 and TBC1D1?
Akt substrate of 160 kDa (called AS160 or TBC1D4) and TBC1D1, Rab GTPase-activating proteins that regulate glucose transport, become phosphorylated with exercise or insulin stimulation. Evidence suggests that this convergence may prove to be imperfect, and each stimulus will produce a unique phosphosignature, providing a plausible mechanism for their apparently unique and overlapping roles in exercise- and insulin-stimulated glucose transport.
Cartee
Gregory D
GD
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, 48109-2214, USA. gcartee@umich.edu
Funai
Katsuhiko
K
D000818:Animals; D020690:GTPase-Activating Proteins / Q000378:metabolism*; D051275:Glucose Transporter Type 4 / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D051379:Mice; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000378:metabolism; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*; D051381:Rats
D020690:GTPase-Activating Proteins; D051275:Glucose Transporter Type 4; D007328:Insulin; D011506:Proteins; C540572:TBC1D1 protein, rat; C533101:TBC1D4 protein, rat