Cell signaling in space and time: where proteins come together and when they're apart.
Signal transduction can be defined as the coordinated relay of messages derived from extracellular cues to intracellular effectors. More simply put, information received on the cell surface is processed across the plasma membrane and transmitted to intracellular targets. This requires that the activators, effectors, enzymes, and substrates that respond to cellular signals come together when they need to.
Scott
John D
JD
Department of Pharmacology, Howard Hughes Medical Institute, Box 357750, University of Washington School of Medicine, Seattle, WA 98195, USA. scottjdw@u.washington.edu
Pawson
Tony
T
D000818:Animals; D002451:Cell Compartmentation; D002462:Cell Membrane / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism*; D004798:Enzymes / Q000378:metabolism; D006801:Humans; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000378:metabolism; D054730:Protein Interaction Domains and Motifs; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction; D013997:Time Factors; D014158:Transcription, Genetic
D004798:Enzymes; D046912:Multiprotein Complexes; D011506:Proteins