title: [Epidemiological, clinical and therapeutic aspects of severe malaria in adults in hospital in Antananarivo, Madagascar].
abstract: Few data are available about severe malaria in Madagascar. Our aims were to describe epidemiological, clinical and therapeutic aspects of severe malaria in patients in Antananarivo. We conducted a retrospective study from 1 March 2006 to 31 March 2008 at the infectious disease department. We recorded 61 cases of severe malaria among 1,803 in patients. Sex ratio was 2 and average age was 35.3 years old. Three pregnant women were recorded among women (15.8%). Self-medication was registered in 23%. Among 35 patients who received first medical care, no one had parasitological examination. The treatment was inadequate for all patients (n = 19). Conscience impairment (65.6%), jaundice (24.6%), seizure (18%) and prostration (14.8%) were the major severe signs. Diagnosis was made 6.54 days after the onset of the disease. Mortality rate was 11.5%. Self-medication, inappropriate primary care and delayed diagnosis represented risk factors for severe malaria in our cohort.
authors: USFR des maladies infectieuses, CHUA HJR de Befelatanana, 101 Antananarivo, Madagascar. rakotoarivelo.rivo@yahoo.fr
authors: R A
authors: RA
authors: Rakotoarivelo
authors: H F R
authors: HF
authors: Raveloson
authors: R
authors: R
authors: Andrianasolo
authors: S H
authors: SH
authors: Razafimahefa
authors: M J D
authors: MJ
authors: Randria
mesh_terms: D000328:Adult; D000962:Antimalarials; D003244:Consciousness Disorders / Q000209:etiology; D042241:Early Diagnosis; D005260:Female; D017052:Hospital Mortality; D006785:Hospitals, University / Q000706:statistics & numerical data; D006786:Hospitals, Urban / Q000706:statistics & numerical data; D006801:Humans; D007565:Jaundice / Q000209:etiology; D008270:Madagascar / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000401:mortality; D012189:Retrospective Studies; D012640:Seizures / Q000209:etiology; D012651:Self Medication; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000962:Antimalarials