title: New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities.
abstract: The synthesis of several (1,2,3,5,6,7-hexahydro-1,5:3,7-dimethano-4-benzoxonin-3-yl)amines and related compounds is reported. Several of them display very similar activity to memantine as NMDA receptor antagonists. Several derivatives showed a significant level of trypanocidal activity.
authors: Laboratori de Química Farmacèutica, Unitat Associada al CSIC, Facultat de Farmàcia, and Institute of Biomedicine, Universitat de Barcelona, Av Diagonal, 643, Barcelona E-08028, Spain.
authors: María D
authors: MD
authors: Duque
authors: Pelayo
authors: P
authors: Camps
authors: Eva
authors: E
authors: Torres
authors: Elena
authors: E
authors: Valverde
authors: Francesc X
authors: FX
authors: Sureda
authors: Marta
authors: M
authors: López-Querol
authors: Antoni
authors: A
authors: Camins
authors: S Radhika
authors: SR
authors: Prathalingam
authors: John M
authors: JM
authors: Kelly
authors: Santiago
authors: S
authors: Vázquez
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000978:Antiparkinson Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D008559:Memantine / Q000494:pharmacology; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014344:Trypanocidal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects; D014352:Trypanosomiasis / Q000188:drug therapy
chemical_list: D000588:Amines; D000978:Antiparkinson Agents; D016194:Receptors, N-Methyl-D-Aspartate; D014344:Trypanocidal Agents; D008559:Memantine