Two new hepaprotective saponins from Semen celosiae.
Two new oleanolic acid saponins, namely celosin C (1) and celosin D (2), were isolated from the ethanol extract of Semen celosiae. Their structures were identified as celosin C (1) and celosin D (2) by spectroscopic and chemical analyses. The hepatoprotective activity of 1 and 2 with oral dose 1.0, 2.0 and 4.0 mg/kg, respectively, were investigated by carbon tetrachloride (CCl(4))-induced hepatotoxicity in mice. The results indicate that they have significant hepatoprotective effects (p<0.01).
Sun
Zhen-Liang
ZL
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, PR China.
Wang
Ying
Y
Guo
Mei-Li
ML
Li
Yu-Xian
YX
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D034762:Celosia / Q000737:chemistry*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D012639:Seeds
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D012503:Saponins; C554123:celosin C; C554122:celosin D