title: Fine-tuning of GPCR activity by receptor-interacting proteins.
abstract: G protein-coupled receptors (GPCRs) mediate physiological responses to various ligands, such as hormones, neurotransmitters and sensory stimuli. The signalling and trafficking properties of GPCRs are often highly malleable depending on the cellular context. Such fine-tuning of GPCR function can be attributed in many cases to receptor-interacting proteins that are differentially expressed in distinct cell types. In some cases these GPCR-interacting partners directly mediate receptor signalling, whereas in other cases they act mainly as scaffolds to modulate G protein-mediated signalling. Furthermore, GPCR-interacting proteins can have a big impact on the regulation of GPCR trafficking, localization and/or pharmacological properties.
authors: Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
authors: Stefanie L
authors: SL
authors: Ritter
authors: Randy A
authors: RA
authors: Hall
mesh_terms: D000818:Animals; D006801:Humans; D008024:Ligands; D021381:Protein Transport; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008024:Ligands; D043562:Receptors, G-Protein-Coupled; D053422:Receptor-Interacting Protein Serine-Threonine Kinases