Enantioselective Friedel-Crafts alkylation of pyrroles catalyzed by PYBOX-DIPH-Zn(II) complexes.
A highly enantioselective Friedel-Crafts alkylation of pyrroles with 2-enoylpyridine N-oxides catalyzed by chiral PYBOX-DIPH-Zn(II) complexes has been developed. The catalyst offers substantial substrate scope and furnished alkylated pyrroles in excellent yields (up to 99%) and enantioselectivities (up to >99% ee).
Singh
Pradeep K
PK
Department of Chemistry, Indian Institute of Technology, Kanpur, India 208 016.
Singh
Vinod K
VK