[A comparative study on early toxicity of conditioning regimen with or without antithymocyte globulin].
OBJECTIVE
To evaluate the toxicity of conditioning regimens of modified Bu/Cy +/- antithymocyte (ATG) in early stage after allogeneic hematopoietic stem cell transplantation (allo-HSCT).


METHODS
A hundred patients with hematological malignancies undergoing allo-HSCT were assessed. Forty-two patients (group A) were conditioned with modified Bu/Cy regimen, 58 (group B) with modified Bu/Cy+ATG regimen. The occurrence of toxicity during the early stage after transplantation was evaluated and compared, including non-infectious fever, diarrhea, hepatotoxicity, mucositis and hematological toxicity.


RESULTS
In group A and B, the incidence of non-infectious fever was 4.8% vs 81.0%, transaminase elevation 59.5% vs 65.5%, bilirubin elevation 16.7% vs 48.3%, diarrhea 59.5% vs 79.3% and mucositis 45.2% vs 37.9%, respectively, white blood cells reached zero occurred at a median of +3 d and -3 d, the rate of red cell and platelet transfusion-dependence, within 10 days before transplantation was 11.9% vs 32.8 and 16.7% vs 82.8%, respectively.


CONCLUSIONS
Significant higher incidence of non-infectious fever, diarrhea, hepatotoxicity, leukopenia, and transfusion dependence is found and considered to be related to the administration of ATG in the conditioning regimen.
Liu
Dai-hong
DH
Institute of Hematology of Peking University, People's Hospital, Beijing 100044, China.
Liu
Jing
J
Liu
Kai-yan
KY
Xu
Lan-ping
LP
Chen
Huan
H
Chen
Yu-hong
YH
Han
Wei
W
Wang
Yu
Y
Zhang
Xiao-hui
XH
Huang
Xian-jun
XJ
D000293:Adolescent; D000328:Adult; D000961:Antilymphocyte Serum / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D019337:Hematologic Neoplasms / Q000601:surgery; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D019172:Transplantation Conditioning / Q000009:adverse effects / Q000379:methods*; D014184:Transplantation, Homologous; D055815:Young Adult
D000961:Antilymphocyte Serum