title: [Relationship between the intima-media complex thickness, the risk factors of cardiovascular diseases, and the level of C-reactive protein in gouty patients].
abstract: OBJECTIVE
  To estimate a relationship between the intima-media thickness (TIM), cardiovascular risk (CVR) factors, and the level of C-reactive protein (CRP) in gouty patients.
  
  
  METHODS
  Eighty-nine patients at an interattack interval were examined. The patients' mean age was 46.0 +/- 11.4 years; the duration of the disease was 5.2 (3.0; 8.9) years. The traditional CVR factors were analyzed. Carotid ultrasound scanning was performed to detect vascular atherosclerotic lesion. The serum CRP concentration was measured by a highly sensitive immunonefelometric assay.
  
  
  RESULTS
  According to the TIM, the patients were divided into 2 groups: 1) 37 patients with signs of carotid atherosclerotic lesion (TIM > or = 0.9 mm); 2) 52 patients with a TIM of less than 0.9 mm. The ages at the moment of examination and at the onset of the disease, the duration of the disease, as well as systolic blood pressure, and the risk of myocardial ischemia were greater in Group 1 than those in Group 2. In patients with atherosclerosis, the concentration of CRP was statistically significantly higher than that in patients without this condition.
  
  
  CONCLUSIONS
  By complementing the classical CVR factors, CRP may be a predictor of cardiovascular diseases and their complications in patients with gout at an interattack interval.
authors: A E
authors: AE
authors: Il'ina
authors: E I
authors: EI
authors: Varfolomeeva
authors: A V
authors: AV
authors: Volkov
authors: E S
authors: ES
authors: Mach
authors: E N
authors: EN
authors: Aleksandrova
authors: A A
authors: AA
authors: Novikov
authors: E V
authors: EV
authors: Il'inykh
authors: V G
authors: VG
authors: Barskova
authors: E L
authors: EL
authors: Nasonov
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000473:pathology; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D006073:Gout / Q000097:blood / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013997:Time Factors; D017539:Tunica Intima / Q000000981:diagnostic imaging* / Q000473:pathology; D017540:Tunica Media / Q000000981:diagnostic imaging* / Q000473:pathology; D014463:Ultrasonography
chemical_list: D002097:C-Reactive Protein