title: [Preparation and transdermal diffusion of flexible nanoliposomes of ginkgolide B].
abstract: OBJECTIVE
  To prepare flexible nanoliposomes of Ginkgolid B (GB) and study the transdermal diffusion law.
  
  
  METHODS
  Flexible nanoliposomes of GB were prepared by film dispersion method, and the shape and particle size of nanoliposomes were analyzed. GB permeation tests in vitro through the skin of rats were performed in modified Franz diffusion cell. The accumulated permeation amounts of GB alcoholic solution, flexible nanoliposomes of GB and ordinary nanoliposomes of GB were compared.
  
  
  RESULTS
  The average encapsulation percentage, the particle size, and the Zata potential of the flexible nanoliposomes were (89.52 +/- 1.76)%, and was (208.3 +/- 25.49) nm, and was -49.2 mV, respectively. The accumulated permeation amount of flexible nanoliposomes in 8 hours was 189.97 microg x cm(-2), and its transdermal permeability in 8 hours was 23.75 microg x cm(-2) x h(-1).
  
  
  CONCLUSIONS
  The encapsulation percentage of the flexible nanoliposomes is good,and the stability of the GB nanoliposomes is fine. Flexible nanoliposomes can significantly enhance the diffusion rate of GB through the skin of rats.
authors: College of Life Science, Northwest University, Xi'an 710069, China. liu-_-ting@163.com
authors: Ting
authors: T
authors: Liu
authors: Xiaolong
authors: X
authors: Zhen
authors: Hao
authors: H
authors: Cheng
authors: Weize
authors: W
authors: Li
authors: Baohua
authors: B
authors: Hao
mesh_terms: D000818:Animals; D005260:Female; D046934:Ginkgolides / Q000737:chemistry* / Q000493:pharmacokinetics; D007783:Lactones / Q000737:chemistry* / Q000493:pharmacokinetics; D008081:Liposomes / Q000737:chemistry* / Q000493:pharmacokinetics; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010539:Permeability; D011897:Random Allocation; D012869:Skin Absorption
chemical_list: D046934:Ginkgolides; D007783:Lactones; D008081:Liposomes; C045856:ginkgolide B