Effect of honey versus intergel in intraperitoneal adhesion prevention and colonic anastomotic healing: a randomized controlled study in rats.
BACKGROUND
Intra-abdominal adhesion formation and reformation after surgery are still an unavoidable event in spite of modern surgical techniques and are a cause of significant morbidity, resulting in infertility, pain and intestinal obstruction.


OBJECTIVE
To investigate the effect of honey in adhesion prevention and colonic anastomotic healing in rats.


METHODS
In the present study, 75 male Sprague-Dawley rats were used and divided into 3 groups for study: [25 rats for each], the intergel, honey and control groups. After the scheduled two-week's post-operative period, all survived rats were reopened for second-look laparotomy to detect the following parameters: a - adhesion, b - manometric study, c - histopathological study.


RESULTS
The author found that the total adhesion score, the manometric values and the histopathological study among the three studied groups showed statistically significant difference and in favor of the honey-treated rats.


CONCLUSIONS
Honey surpasses the intergel for the healing power and adhesion prevention.
Saber
Aly
A
Port-Fouad General Hospital, Department of General Surgery, Port-Fouad, Port-Said, Egypt. alysaber54@gmail.com
D000464:Alginates / Q000008:administration & dosage*; D000704:Analysis of Variance; D000714:Anastomosis, Surgical / Q000009:adverse effects* / Q000379:methods; D000818:Animals; D001707:Biopsy, Needle; D003082:Colectomy / Q000009:adverse effects / Q000379:methods; D004195:Disease Models, Animal; D005290:Ferric Compounds / Q000008:administration & dosage*; D005782:Gels; D006722:Honey; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007150:Immunohistochemistry; D008297:Male; D008365:Manometry; D010532:Peritoneal Diseases / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D010537:Peritoneum / Q000187:drug effects; D011336:Probability; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012680:Sensitivity and Specificity; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*; D014945:Wound Healing / Q000187:drug effects*
D000464:Alginates; D005290:Ferric Compounds; D005782:Gels; C118495:hyaluronate alginate; C550243:intergel; D006820:Hyaluronic Acid