Synthesis, characterization, bioactivities of copper complexes with N-allyl di(picolyl)amine.
Four copper(II) complexes with N-allyl di(picolyl)amine were synthesized and characterized by physico-chemical and spectroscopic methods. The spectrophotometric and fluorescence titration data indicate that the [(Aldpa)Cu(L)](ClO(4))(2) (L=dppz, dione, phen) with conjugated aromatic rings as coordinated ligands can be inserted into the base stacks of DNA more deeply than the [(Aldpa)CuCl(2)]. The copper(II) complexes [(Aldpa)Cu(L)](ClO(4))(2) (L=dppz, dione, phen) can inhibit the proliferation of the four cancer cells (Mcf-7, Eca-109, A549 and HeLa) with IC(50) 0.5-19.2 microM, which is larger than that (23.2-84.3 microM) of [(Aldpa)CuCl(2)], suggesting their inhibiting activities on the four cancer cells are correlated with their DNA-binding properties. However, the selectivity of [(Aldpa)CuCl(2)] to cancer cells is better than that of the other three complexes [(Aldpa)Cu(L)](ClO(4))(2), which indicates the substituents introduced on the secondary amino nitrogen atom of dpa have great contribution to the antitumor activities of these copper(II) complexes.
Chen
Qiu-Yun
QY
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, PR China. chenqy@ujs.edu.cn
Fu
Hai-Jian
HJ
Huang
Juan
J
Zhang
Rong-Xian
RX
D000498:Allyl Compounds / Q000737:chemistry* / Q000494:pharmacology; D000588:Amines / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
D000498:Allyl Compounds; D000588:Amines; D003300:Copper; D004247:DNA