title: Glutathione-S-transferase (GSTM1, GSTT1) and the risk of gastrointestinal cancer in a Korean population.
abstract: OBJECTIVE
  To evaluate the association of glutathione S-transferase mu (GSTM1) and glutathione S-transferase theta (GSTT1) null genotypes with the risk of gastric cancer (GC) and colorectal cancer (CRC) in a South Korean population.
  
  
  METHODS
  We conducted a population-based, large-scale case-control study including 2213 GCs, 1829 CRCs, and 1699 controls. Null and non-null genotypes of GSTM1 and GSTT1 were determined using real-time PCR.
  
  
  RESULTS
  The null genotypes of GSTM1 and GSTT1 were not significantly associated with elevated risk of gastric (OR = 1.070, 95% CI = 0.935-1.224; OR = 1.101, 95% CI = 0.963-1.259, respectively) or colorectal cancer (OR = 1.065, 95% CI = 0.923-1.228; OR = 1.041, 95% CI = 0.903-1.200, respectively). The frequency of the combined null GST genotype was not different between the two cancer groups and controls. Moreover, smoking, drinking, and age did not modify the association between these genotypes and the risk of gastric or colorectal cancer.
  
  
  CONCLUSIONS
  GSTM1 and GSTT1 null genotypes were not associated with increased risk of GC or CRC in Koreans.
authors: Department of Preventive Medicine, Chonnam National University Medical School, Donggu, Gwangju City, South Korea.
authors: Jin-Mei
authors: JM
authors: Piao
authors: Min-Ho
authors: MH
authors: Shin
authors: Sun-Seog
authors: SS
authors: Kweon
authors: Hee Nam
authors: HN
authors: Kim
authors: Jin-Su
authors: JS
authors: Choi
authors: Woo-Kyun
authors: WK
authors: Bae
authors: Hyun-Jeong
authors: HJ
authors: Shim
authors: Hyeong-Rok
authors: HR
authors: Kim
authors: Young-Kyu
authors: YK
authors: Park
authors: Yoo-Duk
authors: YD
authors: Choi
authors: Soo-Hyun
authors: SH
authors: Kim
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1