title: [Study advancement of calpain and apoptosis following cerebral ischemia].
abstract: Calpains, calcium-activated cysteine proteases with a neutral pH optimum, lead to degration of cystoskeletion and structural protein, and delayed neuronal death. The activation of calpains contribute to apoptosis. Calpain inhibitors provide a novel and potential treatment for cerebral ischemia due to improvement of cerebral infarct and ischemia.
authors: Institue of Acupuncture and Moxibustion, Frist Teaching Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors: Jian
authors: J
authors: Liu
authors: Junfeng
authors: J
authors: Xu
authors: Guangjun
authors: G
authors: Wang
authors: Mingxing
authors: M
authors: Yang
authors: Lin
authors: L
authors: Guo
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000627:therapeutic use*; D002154:Calpain / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D006801:Humans
chemical_list: D002135:Calcium-Binding Proteins; C033668:calpastatin; D002154:Calpain