Helicase multitasking in ribosome assembly.
In this issue of Molecular Cell, Bohnsack et al. (2009) identify multiple binding sites of the RNA helicase Prp43 on preribosomal RNA. The target regions suggest distinct functions of Prp43 in ribosome biogenesis.
Guenther
Ulf-Peter
UP
Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA.
Jankowsky
Eckhard
E
D053487:DEAD-box RNA Helicases / Q000172:deficiency / Q000378:metabolism*; D008954:Models, Biological; D011485:Protein Binding; D012322:RNA Precursors / Q000378:metabolism; D012331:RNA, Fungal / Q000737:chemistry / Q000235:genetics; D012335:RNA, Ribosomal / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
D012322:RNA Precursors; D012331:RNA, Fungal; D012335:RNA, Ribosomal; D029701:Saccharomyces cerevisiae Proteins; C109034:PRP43 protein, S cerevisiae; D053487:DEAD-box RNA Helicases