In vitro emulsification assessment of new silicone oils.
OBJECTIVE
To investigate whether the emulsification of conventional silicone oils can be reduced by adding small amounts of silicone molecules of a very long chain length.


METHODS
Siluron 1000, Siluron 2000, Siluron 5000, Acri.Sil-Ol 5000, Oxane 5700, Densiron 68 LV, Densiron 68 and Densiron 68 HV (0.5 ml) were each tested along with either plasma or serum (0.5 ml) in a glass cuvette. Emulsification was induced by sonication and documented by photography. The total area of emulsified oil was assessed using the ImageJ software.


RESULTS
The addition of small amounts of very-long-chain silicone molecules significantly reduced the emulsification for 1000 cSt silicone oil (Siluron 2000) and for 1000 cSt silicone oil with an admixture of F6H8 (Densiron 68 HV).


CONCLUSIONS
New low-viscosity silicone oils show a reduced emulsification similar to that of 5000 cSt oils. In future, it may be possible to avoid using 5000 cSt oils. The findings may foster silicone oil surgery in general, and in particular the application of small-incision techniques.
Caramoy
Albert
A
University of Cologne, Center of Ophthalmology, Department of Vitreo-Retinal Surgery, Kerpener Str. 62, Cologne 50924, Germany. acaramoy@yahoo.co.uk
Schröder
Sabine
S
Fauser
Sascha
S
Kirchhof
Bernd
B
D045703:Emulsifying Agents / Q000494:pharmacology*; D004655:Emulsions / Q000737:chemistry; D006801:Humans; D010949:Plasma; D044967:Serum; D012827:Silicone Oils / Q000737:chemistry*; D012828:Silicones / Q000737:chemistry*
D045703:Emulsifying Agents; D004655:Emulsions; D012827:Silicone Oils; D012828:Silicones