title: Use of a novel autologous cell-harvesting device to promote epithelialization and enhance appropriate pigmentation in scar reconstruction.
abstract: BACKGROUND
  Epidermal replacement is an important step in the management of patients with post-traumatic and iatrogenic scars. Skin-colour variation from disease or trauma causes significant changes in self-image and appearance.
  
  
  OBJECTIVE
  The aim of our study was to analyse the results obtained with a novel autologous cell-harvesting system (ReCell) for epidermal replacement in patients with post-traumatic scars that had not improved with any other surgical procedure.
  
  
  METHODS
  We recruited 30 patients with post-traumatic or iatrogenic scars admitted to our department over 2 years. The primary endpoints of the study were: (i) time for complete epithelialization (both treated area and biopsy site) and (ii) aesthetic and functional quality of the epitheliaization (colour, joint contractures). Infections, inflammations or any adverse effects of the procedure were also reported.
  
  
  RESULTS
  In total, 30 patients were analysed. The aesthetic and functional outcomes were rated by both patient and surgeon. Pigmentation was rated by the Vancouver Scar Scale. Most (80%) of the patients had an excellent or good outcome, with pigmentation rated as normal in 60% of the group.
  
  
  CONCLUSIONS
  The procedure is a feasible, simple and safe technique. It gives similar results to skin grafting but because it harvests from much smaller areas, can open possible future applications in the management of patients with large scars.
authors: Department of Plastic and Reconstructive Surgery, University Tor Vergata, Rome, Italy. valeriocervelli@libero.it
authors: V
authors: V
authors: Cervelli
authors: B
authors: B
authors: De Angelis
authors: D
authors: D
authors: Spallone
authors: L
authors: L
authors: Lucarini
authors: A
authors: A
authors: Arpino
authors: A
authors: A
authors: Balzani
mesh_terms: D000328:Adult; D001706:Biopsy; D002921:Cicatrix / Q000473:pathology / Q000601:surgery*; D004817:Epidermis / Q000637:transplantation*; D004954:Esthetics; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012867:Skin / Q000473:pathology; D012880:Skin Pigmentation; D020858:Tissue and Organ Harvesting / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult