title: Genome sequence analysis of the first human West Nile virus isolated in Italy in 2009.
abstract: In 2009, six new human cases of West Nile neuroinvasive disease (WNND) were identified in Veneto region, following the six cases already reported in 2008. A human West Nile virus (WNV) isolate was obtained for the first time from an asymptomatic blood donor. Whole genome sequence of the human WNV isolate showed close phylogenetic relatedness to the Italy-1998-WNV strain and to other WNV strains recently isolated in Europe, with the new acquisition of the NS3-Thr249Pro mutation, a trait associated with avian virulence, increased virus transmission, and the occurrence of outbreaks in humans.
authors: Department of Histology, Microbiology, and Medical Biotechnologies, University of Padua, Padua, Italy.
authors: L
authors: L
authors: Barzon
authors: E
authors: E
authors: Franchin
authors: L
authors: L
authors: Squarzon
authors: E
authors: E
authors: Lavezzo
authors: S
authors: S
authors: Toppo
authors: T
authors: T
authors: Martello
authors: S
authors: S
authors: Bressan
authors: S
authors: S
authors: Pagni
authors: M
authors: M
authors: Cattai
authors: A
authors: A
authors: Piazza
authors: M
authors: M
authors: Pacenti
authors: R
authors: R
authors: Cusinato
authors: G
authors: G
authors: Palù
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004196:Disease Outbreaks; D016678:Genome; D006801:Humans; D007558:Italy; D008969:Molecular Sequence Data; D010802:Phylogeny; D014901:West Nile Fever / Q000453:epidemiology; D014902:West Nile virus / Q000235:genetics* / Q000302:isolation & purification*