Glycodelin-A modulates cytokine production of peripheral blood natural killer cells.
Glycodelin-A increased the secretion of interleukin-6, interleukin-13, and granulocyte-macrophage colony-stimulating factor from natural killer cells in the peripheral blood but does not affect their viability, cell death, and cytotoxicity. These data suggest that glycodelin-A contributes to the cytokine shift in early pregnancy.
Lee
Cheuk-Lun
CL
Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong, People's Republic of China.
Chiu
Philip C N
PC
Lam
Kevin K W
KK
Chan
Rachel W S
RW
Chu
Ivan K
IK
Koistinen
Riitta
R
Koistinen
Hannu
H
Seppälä
Markku
M
Lee
Kai-Fai
KF
Yeung
William S B
WS
D016923:Cell Death / Q000276:immunology; D002470:Cell Survival / Q000276:immunology; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D003656:Decidua / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins / Q000276:immunology* / Q000378:metabolism / Q000494:pharmacology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000276:immunology / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D018793:Interleukin-13 / Q000276:immunology / Q000378:metabolism; D015850:Interleukin-6 / Q000276:immunology / Q000378:metabolism; D007694:Killer Cells, Natural / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000276:immunology* / Q000378:metabolism / Q000494:pharmacology; D011261:Pregnancy Trimester, First / Q000276:immunology / Q000378:metabolism; D014327:Trophoblasts / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines; D000071816:Glycodelin; D006023:Glycoproteins; C508600:IL6 protein, human; D018793:Interleukin-13; D015850:Interleukin-6; C045246:PAEP protein, human; D011257:Pregnancy Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor