Production of nitrogen-13-labeled ammonia by using 11MeV medical cyclotron: our experience.
A method has been developed for the production of (13)N-labeled ammonia in usable quantities with negligible contamination. A system was developed and a process for the production of nitrogen-13 ammonium ions from a target material in the form of a dilute solution of ethanol in natural water, i.e. the bombardment of oxygen-16 with protons within the target material. The system includes a device for producing a proton beam which travels along a pre selected path and strikes the target material in a target chamber. This target chamber is positioned in the path of the proton beam such that subjection of the target material to the beam produces nitrogen-13 atoms and alpha particles. These nitrogen-13 atoms are converted in the aqueous solution to ammonium ions and oxides and are conducted from the target holder to a purification cartridge for collecting a purified product containing the ammonium ions.
Kumar
Rajeev
R
Siemens Ltd India, Healthcare Sector Imaging, New Delhi, India.
Singh
Harkirat
H
Jacob
Mattakaottu
M
Anand
Surendra Pal
SP
Bandopadhyaya
Guru Pad
GP
D000641:Ammonia / Q000737:chemistry* / Q000528:radiation effects*; D017357:Cyclotrons; D007553:Isotope Labeling / Q000379:methods*; D009590:Nitrogen Radioisotopes / Q000737:chemistry* / Q000528:radiation effects*
D009590:Nitrogen Radioisotopes; D000641:Ammonia