Biomarkers identification and detection based on GMR sensor and sub 13 nm magnetic nanoparticles.
In this paper, we present a ultra high sensitive (Zeptomole, 10(-21)) technique to enable the detection of any potential low abundance biomarkers. We demonstrated for the first time the detection of sub 13nm high-moment magnetic nanoparticle and the implementation of a novel magnetoresistive (GMR) biosensor concept with higher sensitivity and 10 times lower external field in real biomarker sensing schemes. A potential lung cancer biomarker, interleukin-6 (IL-6), was successfully detected with extremely low concentration (as few as only 200 pieces of IL-6). Together with other features of GMR sensor systems like low-cost, portability, easy-to-use, our demonstrated device may lead to future family-based personalized medicine for cancer prevention.
Li
Yuanpeng
Y
Department of Electrical and Computer Engineering, Minneapolis, MN 55455, USA.
Jing
Ying
Y
Yao
Xiaofeng
X
Srinivasan
Balasubramanian
B
Xu
Yunhao
Y
Xing
Chengguo
C
Wang
Jian-Ping
JP
D015415:Biomarkers / Q000032:analysis*; D015374:Biosensing Techniques / Q000295:instrumentation*; D017097:Electric Impedance; D008280:Magnetics / Q000295:instrumentation*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D019809:Streptavidin / Q000737:chemistry
D015415:Biomarkers; D019809:Streptavidin