title: Model based reconstruction for simultaneously imaging cerebral blood flow and De-oxygen hemoglobin distribution.
abstract: Laser speckle imaging (LSI) and optical intrinsic signal (OIS) imaging are shown to produce high resolution information of cerebral blood flow(CBF) and de-oxygen hemoglobin(dHb) respectively. However, the cortex curvature and non-uniform illumination always result in the inhomo-geneous impact and thus distort the CBF and dHb results. In this paper, we propose to extract both CBF and dHb images from raw speckle images. A parametric model for such inhomogeneity is estimated by adaptive window median-mean filtering and curve fitting technique to reconstruct the CBF and dHb image.
authors: Med-X Research Institute, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China.
authors: Peng
authors: P
authors: Miao
authors: Nan
authors: N
authors: Li
authors: Abhishek
authors: A
authors: Rege
authors: Shanbao
authors: S
authors: Tong
authors: Nitish
authors: N
authors: Thakor
mesh_terms: D000465:Algorithms; D000818:Animals; D001698:Biomedical Engineering / Q000379:methods; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004867:Equipment Design; D005260:Female; D006454:Hemoglobins / Q000737:chemistry* / Q000378:metabolism; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007834:Lasers; D008027:Light; D008029:Lighting; D016011:Normal Distribution; D010100:Oxygen / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D006454:Hemoglobins; D010100:Oxygen