Epidermal growth factor receptor overexpressed malignant fibrous histiocytoma associated with recurrent meningothelial meningioma.
A 71-year-old woman presented with a rare case of malignant fibrous histiocytoma (MFH) associated with recurrent meningothelial meningioma. The neuroimaging findings were consistent with a diagnosis of recurrent meningioma. Surgical removal was performed. Histological and immunohistochemical examinations detected meningothelial and MFH tumor components. The MFH component showed diffuse 3+ staining for epidermal growth factor receptor protein, predominantly located on the cell membrane and to a lesser extent within the cytoplasm. However, a fluorescein isothiocyanate analysis detected no amplification of epidermal growth factor receptor gene.
Caltabiano
Rosario
R
Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Catania, Italy.
Parisi
Giuseppe
G
Albanese
Vincenzo
V
Lanzafame
Salvatore
S
D000368:Aged; D001037:Aphasia / Q000209:etiology; D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism*; D066246:ErbB Receptors / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D005260:Female; D016650:Fluorescein-5-isothiocyanate; D005784:Gene Amplification; D006423:Hemianopsia / Q000209:etiology; D051677:Histiocytoma, Malignant Fibrous / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000601:surgery; D008578:Meninges / Q000473:pathology / Q000601:surgery; D008579:Meningioma / Q000473:pathology* / Q000601:surgery; D008940:Mitotic Index; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D010291:Paresis / Q000209:etiology; D010296:Parietal Lobe / Q000473:pathology / Q000601:surgery
D014408:Biomarkers, Tumor; D066246:ErbB Receptors; D016650:Fluorescein-5-isothiocyanate