Multiphoton autofluorescence microscopy and second harmonic generation microscopy of oral epithelial neoplasms.
The objective of this study was to evaluate the nonlinear optical microscopy techniques of multiphoton autofluorescence microscopy (MPAM) and second harmonic generation microscopy (SHGM) for noninvasive imaging of oral epithelial carcinogenesis. In vivo imaging was performed in a hamster model for oral carcinogenesis to characterize optical and morphometric alterations during neoplastic transformation. Data is presented showing alterations in morphometry and collagen density during the precancerous phase of neoplastic transformation.
Vargas
Gracie
G
University of Texas Medical Branch, USA. grvargas@utmb.edu
Shilagard
Tuya
T
Ho
Ki-Hong
KH
McCammon
Susan
S
D000818:Animals; D006224:Cricetinae; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008647:Mesocricetus; D009062:Mouth Neoplasms / Q000473:pathology*; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity