Antiplasmodial and cytotoxic activity of khellactone derivatives from Angelica purpuraefolia Chung.
The methanolic extract of the rhizomes parts of Agelica purpuraefolia was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method. Two natural khellactone, (+)-4'-Decanoyl-cis-khellactone (1) and (+)-3'-Decanoyl-cis-khellactone (2) were isolated from the rhizomes parts of A. purpuraefolia. Two compounds were evaluated for in vitro antiplasmodial activities as well as their cytotoxic potential on SK-OV-3 cancer cell line cells. Compounds 1, 2 showed notable growth inhibitory activity against chloroquine-sensitive strains of Plasmodium falciparum with IC(50) values from 1.5 and 2.4 microM. This compound showed no significant cytotoxicity (IC(50) > 100 microM) evaluated using SK-OV-3 cancer cell line cells. This is the first report on the antiplasmodial activity of the compounds from A. purpuraefolia.
Chung
Ill-Min
IM
Department of Applied Life Science, Kon Kuk University, Seoul, 143-701, South Korea.
Ghimire
Bimal Kumar
BK
Kang
Eun-Young
EY
Moon
Hyung-In
HI
D029969:Angelica / Q000737:chemistry*; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D003374:Coumarins; D010936:Plant Extracts; C520900:khellactone