title: Impaired erythrocyte filterability of spontaneously hypertensive rats: investigation by nickel filtration technique.
abstract: BACKGROUND
  Deformability of erythrocytes plays a key role in the impairment of the microcirculation in hypertension. However, erythrocyte deformability in spontaneously hypertensive rats (SHR) during development of hypertension has not been fully investigated so far.
  
  
  RESULTS
  Erythrocyte filterability (whole cell deformability) was investigated in relation to blood pressure measured by the tail-cuff method in SHR and age-matched Wistar-Kyoto rats (WKY), using a highly sensitive and reproducible nickel mesh filtration technique. Impaired erythrocyte filterability was marked (37.0+/-17.5%) in prehypertensive young SHR (7 weeks of age) and sustained (51.6+/-13.3%) in hypertensive mature SHR (18 weeks of age), when compared with that of age-matched WKY (62.1+/-7.2% in 7 weeks of age, P<0.005, and 71.1+/-3.9% in 18 weeks of age, P<0.005, respectively). This impairment in SHR could not be explained by the mean corpuscular volume or mean corpuscular hemoglobin concentration of erythrocytes, but the erythrocyte count was significantly (P<0.005) greater in SHR than in the age-matched WKY.
  
  
  CONCLUSIONS
  Although the precise mechanisms remain to be elucidated, markedly impaired erythrocyte filterability in SHR is considered to contribute to the development and maintenance of genetic hypertension. (Circ J 2010; 74: 129 - 136).
authors: Department of Medicine & Biosystemic Science, Kyushu University, Japan.
authors: Kyoko
authors: K
authors: Ariyoshi
authors: Toru
authors: T
authors: Maruyama
authors: Keita
authors: K
authors: Odashiro
authors: Koichi
authors: K
authors: Akashi
authors: Takehiko
authors: T
authors: Fujino
authors: Nobuhiro
authors: N
authors: Uyesaka
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D004195:Disease Models, Animal; D004906:Erythrocyte Count; D004907:Erythrocyte Deformability / Q000235:genetics* / Q000502:physiology*; D005374:Filtration; D006339:Heart Rate / Q000502:physiology; D006973:Hypertension / Q000097:blood* / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008833:Microcirculation / Q000502:physiology; D009532:Nickel; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D009532:Nickel