title: Variation of treatment planning parameters (D90 HR-CTV, D 2cc for OAR) for cervical cancer tandem ring brachytherapy in a multicentre setting: comparison of standard planning and 3D image guided optimisation based on a joint protocol for dose-volume constraints.
abstract: OBJECTIVE
  To perform a qualitative and quantitative comparison of different treatment planning methods used in different centres for MRI-based brachytherapy (BT) of cervical cancer.
  
  
  METHODS
  Two representative patients with advanced cervical cancer (1 "limited volume case"; 1 "extensive volume case") were planned for brachytherapy (BT) with a tandem-ring applicator by six different centres. During a workshop all centres produced an institutional standard plan and an MRI-based adaptive treatment plan for each case. Optimisation was based on the fractionation schedule (HDR, PDR) and method according to the institutional protocol.
  
  
  RESULTS
  The loading pattern, dwell times, shape of the point A isodose varied considerably between institutional standard plans, as did dose-volume parameters for high risk CTV (HR-CTV) and also for the D(2cc) for OAR, violating the dose-volume constraints in many situations. During optimisation, the centres stayed as close as possible to the standard loading pattern and dwell times. The dose distributions and dose-volume parameters between the plans from the different centres became much more comparable after optimisation. The prescribed dose to the HR-CTV could be achieved in the limited volume case by all centres, in the extensive case only if additional needles were applied.
  
  
  CONCLUSIONS
  Treatment planning for gynaecologic brachytherapy based on different traditions shows less variation in regard to target coverage and OAR dose, when 3D image-based optimisation is performed with a uniform prescription protocol.
authors: Department of Radiation Oncology, University Medical Centre Utrecht, The Netherlands.
authors: Ina M
authors: IM
authors: Jürgenliemk-Schulz
authors: Stefan
authors: S
authors: Lang
authors: Kari
authors: K
authors: Tanderup
authors: Astrid
authors: A
authors: de Leeuw
authors: Christian
authors: C
authors: Kirisits
authors: Jacob
authors: J
authors: Lindegaard
authors: Primoz
authors: P
authors: Petric
authors: Robert
authors: R
authors: Hudej
authors: Richard
authors: R
authors: Pötter
mesh_terms: D001918:Brachytherapy / Q000592:standards; D005260:Female; D006801:Humans; D009929:Organ Size; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000592:standards; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*