title: Inflammation and central nervous system Lyme disease.
abstract: Lyme disease, caused by the bacterium Borrelia burgdorferi, can cause multi-systemic signs and symptoms, including peripheral and central nervous system disease. This review examines the evidence for and mechanisms of inflammation in neurologic Lyme disease, with a specific focus on the central nervous system, drawing upon human studies and controlled research with experimentally infected rhesus monkeys. Directions for future human research are suggested that may help to clarify the role of inflammation as a mediator of the chronic persistent symptoms experienced by some patients despite antibiotic treatment for neurologic Lyme disease.
authors: Department of Psychiatry, Columbia University, New York, NY 10032, USA. baf1@columbia.edu
authors: Brian A
authors: BA
authors: Fallon
authors: Elizabeth S
authors: ES
authors: Levin
authors: Pernilla J
authors: PJ
authors: Schweitzer
authors: David
authors: D
authors: Hardesty
mesh_terms: D000818:Animals; D020274:Autoimmune Diseases of the Nervous System / Q000469:parasitology / Q000473:pathology / Q000503:physiopathology*; D002490:Central Nervous System / Q000469:parasitology / Q000473:pathology / Q000503:physiopathology*; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004679:Encephalomyelitis / Q000276:immunology / Q000469:parasitology / Q000503:physiopathology*; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology; D020852:Lyme Neuroborreliosis / Q000276:immunology / Q000503:physiopathology*; D008253:Macaca mulatta / Q000276:immunology / Q000469:parasitology; D017628:Microglia / Q000502:physiology
chemical_list: D016207:Cytokines