title: [Intracerebral infiltration by monoclonal plasmacytoid cells in Waldenstrom's macroglobulinemia: a case report and review of the literature].
abstract: OBJECTIVE
  To sum up the clinical experience of the diagnosis and treatment of intracerebral infiltration by monoclonal plasmacytoid cells in Waldenstrom's macroglobulinemia(Bing-Neel syndrome).
  
  
  METHODS
  The clinical data of the diagnosis and treatment of a case of Bing-Neel syndrome was analyzed.
  
  
  RESULTS
  A 56-year-old male was diagnosed as Waldenstrom's macroglobulinemia one year ago, and presented with persistent headache during the treatment period. Magnetic resonance imaging showed a high intensity area on T2-weighed images in the right frontal lobe which was well enhanced by gadolinium-diethylenetriaminepenta-acetic acid. Infiltration of neoplastic cells was confirmed by biopsy. Immunohistochemical examination showed that mature plasmacytoid cells in the cerebral parenchyma were immunoglobulin M positive.
  
  
  CONCLUSIONS
  Infiltration in CNS (Bing-Neel syndrome) is uncommon in Waldenstrom's macroglobulinemia. As there is no effective therapy for this Bing-Neel syndrome, combination of radiation and chemotherapy should be considered for this situation.
authors: Department of Hematology, Xinqiao Hospital, Third Military University, Chongqing 400037, China.
authors: Jie-Ping
authors: JP
authors: Li
authors: Xiao-Lin
authors: XL
authors: Yin
authors: Pei-Yan
authors: PY
authors: Kong
authors: Xing-Hua
authors: XH
authors: Chen
authors: Dong-Feng
authors: DF
authors: Zeng
authors: Xi-Xi
authors: XX
authors: Xiang
authors: Xian-Gui
authors: XG
authors: Peng
mesh_terms: D001921:Brain / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D008258:Waldenstrom Macroglobulinemia / Q000473:pathology*