title: The efficacy of ribavirin in the treatment of Crimean-Congo hemorrhagic fever in Eastern Black Sea region in Turkey.
abstract: BACKGROUND
  The efficiency of ribavirin for treatment of Crimean-Congo hemorrhagic fever (CCHF) is unknown. In the literature, prospective randomized studies investigating the efficacy of ribavirin are not found.
  
  
  OBJECTIVE
  To investigate the efficacy of ribavirin in treatment of patients with CCHF.
  
  
  METHODS
  In this prospective randomized cohort study 136 cases were included between June 2004 and August 2007. The diagnosis was confirmed in the CCHF reference laboratory of Refik Saydam National Hygiene Central Institute of the Turkish Ministry of Health. Patients either received ribavirin plus supportive treatment (Group A) (n=64) or only supportive treatment (Group B) (n=72). For the evaluation of efficacy of ribavirin, various parameters were compared between Group A and Group B.
  
  
  RESULTS
  As well as the similarity of demographic features between the two groups, there were no statistical differences in incubation time; hospitalization time; patients requiring platelet replacement therapy; the time taken for platelet levels to return to normal levels and mortality. In Group B, the rate of tick contact was higher (p=0.03). In Group A, leukocyte levels took longer to return to the normal levels (p=0.02).
  
  
  CONCLUSIONS
  In our study, there was no positive effect determined on clinical or laboratory parameters in CCHF patients treated with ribavirin, also it was observed that leukocyte levels took longer to return to normal (p=0.02) and, while not statistically significant, the longer period of hospitalization (p=0.09) needed was observed as a negative effect. Because of these reasons, it is thought that the use of ribavirin makes no significant contribution to the prognosis of the CCHF disease.
authors: Department of Infectious Disease and Clinical Microbiology, Karadeniz Technical University School of Medicine, 61080 Trabzon, Turkey. iftihar@yahoo.com
authors: Iftihar
authors: I
authors: Koksal
authors: Gurdal
authors: G
authors: Yilmaz
authors: Firdevs
authors: F
authors: Aksoy
authors: Hava
authors: H
authors: Aydin
authors: Ilknur
authors: I
authors: Yavuz
authors: Serap
authors: S
authors: Iskender
authors: Korhan
authors: K
authors: Akcay
authors: Sukru
authors: S
authors: Erensoy
authors: Rahmet
authors: R
authors: Caylan
authors: Kemalettin
authors: K
authors: Aydin
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D003225:Hemorrhagic Fever Virus, Crimean-Congo; D006479:Hemorrhagic Fever, Crimean / Q000188:drug therapy*; D006801:Humans; D007958:Leukocyte Count; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012254:Ribavirin / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome; D014421:Turkey
chemical_list: D000998:Antiviral Agents; D012254:Ribavirin