title: Monitoring intramyocardial reentry using alternating transillumination.
abstract: Intramyocardial reentry is implicated as a primary cause of the most deadly cardiac arrhythmias known as polymorphic ventricular tachycardia and ventricular fibrillation. However, the mechanisms involved in the triggering of such reentry and controlling its subsequent dynamics remain poorly understood. One of the major obstacles has been a lack of adequate tools that would enable 3D imaging of electrical excitation and reentry inside thick ventricular wall. Here, we present a new experimental technique, termed alternating transillumination (AT), aimed at filling this gap. The AT technique utilizes a recently synthesized near-infrared fluorescent voltage-sensitive dye, DI-4-ANBDQBS. We apply AT to study the dynamics of reentry during shock-induced polymorphic ventricular tachycardia in pig myocardium.
authors: State University of New York, Upstate Medical University, Syracuse, NY 13210, USA. mitreab@upstate.edu
authors: Bogdan G
authors: BG
authors: Mitrea
authors: Marcel
authors: M
authors: Wellner
authors: Arkady M
authors: AM
authors: Pertsov
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D001698:Biomedical Engineering / Q000379:methods; D004594:Electrophysiology / Q000379:methods; D004867:Equipment Design; D006329:Heart Conduction System / Q000503:physiopathology*; D006352:Heart Ventricles / Q000473:pathology; D008564:Membrane Potentials; D008955:Models, Cardiovascular; D015233:Models, Statistical; D009206:Myocardium / Q000473:pathology*; D013552:Swine; D013610:Tachycardia; D017180:Tachycardia, Ventricular / Q000473:pathology; D014172:Transillumination