Novel/conceptual floating pulsatile system using high internal phase emulsion based porous material intended for chronotherapy.
The aim of the present study was to design a novel/conceptual delivery system using ibuprofen, anticipated for chronotherapy in arthritis with porous material to overcome the formulation limits (multiple steps, polymers, excipients) and to optimize drug loading for a desired release profile suitable for in vitro investigations. The objective of this delivery system lies in the availability of maximum drug amount for absorption in the wee hours as recommended. Drug loading using 3(2) factorial design on porous carrier, synthesized by high internal phase emulsion technique using styrene and divinylbenzene, was done via solvent evaporation using methanol and dichloromethane. The system was evaluated in vitro for drug loading, encapsulation efficiency, and surface characterization by scanning electron, atomic force microscopy, and customized drug release study. This study examined critical parameters such as solvent volume, drug amount, and solvent polarity on investigations related to drug adsorption and release mostly favoring low-polarity solvent dichloromethane. Overall release in all batches ranged 0.98-52% in acidic medium and 71-94% in basic medium. These results exhibit uniqueness in achieving the least drug release of 0.98%, an ideal one, without using any release modifiers, making it distinct from other approaches/technologies for time and controlled release and for chronotherapy.
Sher
Praveen
P
Department of Pharmaceutics, Bharati Vidyapeeth University, Poona College of Pharmacy and Research Centre, Erandwane, Pune, 411038, Maharashtra, India. sherpraveen@gmail.com
Ingavle
Ganesh
G
Ponrathnam
Surendra
S
Benson
James R
JR
Li
Nai-Hong
NH
Pawar
Atmaram P
AP
D000327:Adsorption; D055870:Drug Chronotherapy; D016503:Drug Delivery Systems; D004655:Emulsions; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry; D000432:Methanol / Q000008:administration & dosage; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D012995:Solubility
D004655:Emulsions; D007052:Ibuprofen; D000432:Methanol