Advantage of next-generation frequency-domain optical coherence tomography compared with conventional time-domain system in the assessment of coronary lesion.
BACKGROUND
Intracoronary optical coherence tomography (OCT) is a high-resolution imaging modality used for evaluation of coronary lesion morphology. However, current time-domain OCT (TD-OCT) have a number of limitations with regard to both procedural usage and safety in the clinical setting. The next-generation frequency-domain OCT (FD-OCT), which has a much faster frame rate and pullback speed than TD-OCT, is expected to overcome these limitations. The aim of this study was to evaluate the feasibility and usability of next generation FD-OCT in the assessment of coronary lesions.


METHODS
A comparison study was performed between FD-OCT and TD-OCT from the aspect of usability (set-up time), qualitatively (rate of clear image segment), and safety (adverse event) in 14 ischemic heart disease patients with 20 previously implanted coronary stents.


RESULTS
The mean time of the OCT procedure in this study from setup to completion of image acquisition was 3.2 +/- 0.8 min for FD-OCT and 11.2 +/- 2.5 min for TD-OCT (P < 0.01). In qualitative image assessment, FD-OCT has the potential to yield a higher rate of clear image segments (CIS) than TD-OCT (99.4% vs. 80.8%, respectively; P < 0.01). In addition to these improved characteristics, there were no ischemic ECG changes or arrhythmia associated with FD-OCT.


CONCLUSIONS
The next-generation intracoronary FD-OCT has better performance in the clinical setting and the potential to overcome several limitations of conventional TD-OCT systems.
Takarada
Shigeho
S
Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
Imanishi
Toshio
T
Liu
Yong
Y
Ikejima
Hideyuki
H
Tsujioka
Hiroto
H
Kuroi
Akio
A
Ishibashi
Kohei
K
Komukai
Kenichi
K
Tanimoto
Takashi
T
Ino
Yasushi
Y
Kitabata
Hironori
H
Kubo
Takashi
T
Nakamura
Nobuo
N
Hirata
Kumiko
K
Tanaka
Atsushi
A
Mizukoshi
Masato
M
Akasaka
Takashi
T
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D018570:Risk Assessment; D015607:Stents; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome