Innate versus acquired immune response in the pathogenesis of recurrent idiopathic pericarditis.
The pathogenesis of recurrent pericarditis is still poorly understood and may be related either to viral infections or autoimmune and autoinflammatory disorders. The immune system plays a major role in the pathogenesis of the disease, modulating individual responses to different noxa and explaining the variable reported recurrence rate (ranging from 20% to 50% of patients) following an attack of acute or recurrent pericarditis. Increasing interest is currently being devoted to autoinflammatory disorders, a group of conditions characterized by spontaneously relapsing and remitting bouts of systemic inflammation without apparent involvement of antigen-specific T cells or significant production of auto-antibodies. Ongoing basic and clinical research is needed to provide further evidence for the understanding of this common and troublesome disease, and to develop targeted and more efficacious therapies.
Cantarini
Luca
L
Interdepartmental Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena, Italy. cantariniluca@hotmail.com
Luca
Cantarini
C
Imazio
Massimo
M
Massimo
Imazio
I
Brucato
Antonio
A
Antonio
Brucato
B
Lucherini
Orso Maria
OM
Maria
Lucherini Orso
LO
Galeazzi
Mauro
M
Mauro
Galeazzi
G
D056704:Adaptive Immunity; D002311:Cardiomyopathy, Dilated / Q000209:etiology*; D010505:Familial Mediterranean Fever; D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate; D009205:Myocarditis / Q000150:complications / Q000235:genetics / Q000276:immunology*; D010496:Pericardium / Q000276:immunology*; D011110:Polymorphism, Genetic; D012008:Recurrence