title: [Molecular functions of polyamines in neoplastic growth and their role in control of the NF-kappaB transcription factor in experimental tumors cells].
abstract: PA were found to promote creation of the NF-kappaB complex with the correspondent DNA sequences (NRE), p50 NF-kappaB-subunit affinity with NRE is essentially magnified in PA presence. This is one of important demonstrations of PA involvement in transcription control. NF-kappaB activity in experimental mammary tumors cells was shown to depend on PA metabolism. Retardation of experimental mammary tumors growth caused by the inhibitors of PA biosynthesis was accompanied with decreased expression of protein products of the NF-kappaB-dependent genes such as c-myc, bcl-xl. It was hypothesized that under PA depletion not classic NF-kappaB (p50/p65 heterodimer) but p50/p50 homodimer is mainly created, and this homodimer, because of PA deficiency, is not able to promote transcription of the gene have been tested.
authors: S P
authors: SP
authors: Zalietok
authors: O A
authors: OA
authors: Orlovs'kyĭ
authors: S V
authors: SV
authors: Hohol'
authors: N O
authors: NO
authors: Aleksandrova
authors: O A
authors: OA
authors: Samoĭlenko
authors: N A
authors: NA
authors: Ihnatenko
authors: O O
authors: OO
authors: Klenov
authors: I V
authors: IV
authors: Malyts'ka
authors: V V
authors: VV
authors: Zhylenko
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D015317:Biogenic Polyamines / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*; D015153:Blotting, Western; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D003198:Computer Simulation; D000518:Eflornithine / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D051379:Mice; D008954:Models, Biological; D016328:NF-kappa B / Q000096:biosynthesis* / Q000235:genetics; D016133:Polymerase Chain Reaction; D014158:Transcription, Genetic
chemical_list: D000970:Antineoplastic Agents; D015317:Biogenic Polyamines; D016328:NF-kappa B; D000518:Eflornithine