title: Membrane homeostasis requires intact pst in extraintestinal pathogenic Escherichia coli.
abstract: In extraintestinal pathogenic Escherichia coli (ExPEC) strains, mutation in the PstSCAB inorganic phosphate transporter results in multiple sensitivity phenotypes and loss of virulence. Here, we show that a pst mutant is subject to an increased outer membrane permeability and that pst copy number influences fatty acids regulation. Such perturbations are likely to participate in the impaired response of pst mutants to their environment.
authors: INRS-Institut Armand-Frappier, Laval, QC, Canada. martin.lamarche@iaf.inrs.ca
authors: Martin G
authors: MG
authors: Lamarche
authors: Josée
authors: J
authors: Harel
mesh_terms: D002462:Cell Membrane / Q000502:physiology*; D002463:Cell Membrane Permeability; D004926:Escherichia coli / Q000235:genetics / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D018628:Gene Dosage; D006706:Homeostasis; D009154:Mutation; D028061:Phosphate Transport Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D029968:Escherichia coli Proteins; D005227:Fatty Acids; D028061:Phosphate Transport Proteins