title: Characterization of pancreatic cancer and intra-abdominal lymph node malignancy using spectrum analysis of endoscopic ultrasound imaging.
abstract: This study assessed the ability of spectral analysis of endoscopic ultrasound (EUS) RF signals acquired in humans in vivo to distinguish between (1) benign and malignant intraabdominal and mediastinal lymph nodes and (2) pancreatic cancer, chronic pancreatitis, and normal pancreas. Mean midband fit, slope, intercept, and correlation coefficient from a linear regression of the calibrated RF power spectra were computed over regions of interest defined by the endoscopist. Linear discriminant analysis was then performed to develop a classification of the resulting spectral parameters. For lymph nodes, classification based on the midband fit and intercept provided 67% sensitivity, 82% specificity, and 73% accuracy for malignant vs. benign nodes. For pancreas, classification based on midband fit and correlation coefficient provided 95% sensitivity, 93% specificity, and 93% accuracy for diseased vs. normal pancreas and 85% sensitivity, 71% specificity, and 85% accuracy for pancreatic cancer vs. chronic pancreatitis. These promising results suggest that mean spectral parameters can provide a non-invasive method to quantitatively characterize pancreatic cancer and lymph malignancy in vivo.
authors: Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA. kumon@ieee.org
authors: Ronald E
authors: RE
authors: Kumon
authors: Michael J
authors: MJ
authors: Pollack
authors: Ashley L
authors: AL
authors: Faulx
authors: Kayode
authors: K
authors: Olowe
authors: Farees T
authors: FT
authors: Farooq
authors: Victor K
authors: VK
authors: Chen
authors: Yun
authors: Y
authors: Zhou
authors: Richard C K
authors: RC
authors: Wong
authors: Gerard A
authors: GA
authors: Isenberg
authors: Michael V
authors: MV
authors: Sivak
authors: Amitabh
authors: A
authors: Chak
authors: Cheri X
authors: CX
authors: Deng
mesh_terms: D000005:Abdomen; D002138:Calibration; D004067:Digestive System Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000401:mortality; D019160:Endosonography / Q000379:methods*; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008223:Lymphoma / Q000000981:diagnostic imaging*; D010179:Pancreas / Q000000981:diagnostic imaging; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D011237:Predictive Value of Tests; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014463:Ultrasonography / Q000379:methods*; D014481:United States / Q000453:epidemiology