NFATc1 in inflammatory and musculoskeletal conditions.
The nuclear factor of activated T-cells (NFAT) family of transcription factors specify developmental pathways and cell fate in vertebrates. NFATc1, in particular, is crucial to multiple seemingly unrelated biologic processes, including heart valve formation, T-cell activation, osteoclast development, and the mitigation of hair follicle stem cell proliferation. Here, we review how our recently generated NFATc1 conditional knockout mouse has contributed to our understanding of this transcription factor in inflammatory and musculoskeletal conditions and their treatment.
Aliprantis
Antonios O
AO
Department of Medicine, Harvard School of Public Health, Boston, MA, USA. aaliprantis@partners.org
Glimcher
Laurie H
LH
D000818:Animals; D019703:Calcineurin / Q000378:metabolism; D065095:Calcineurin Inhibitors; D018859:Hair Follicle / Q000254:growth & development; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D009140:Musculoskeletal Diseases / Q000378:metabolism*; D050778:NFATC Transcription Factors / Q000378:metabolism*; D010012:Osteogenesis
D065095:Calcineurin Inhibitors; D050778:NFATC Transcription Factors; D019703:Calcineurin