Effect of the coating morphology on the drug release from engineered drug-polymer nanocomposites.
The ElectroNanospray process (Nanocopoeia, Inc) transforms drugs and polymers into many nanoscale material states including powders, liquids, encapsulated particles, and coatings. This enabling technology platform allows application of polymers and drugs to the surface of medical devices such as coronary stents in a single-stage process. Modification of ElectroNanospray process parameters resulted in surface coatings with rich morphologies ranging in appearance from smooth and heterogeneous to highly porous and rough (open matrix). The traditional approach of measuring percent release over time by HPLC shows that the drug release profiles change significantly with coating morphology. In this study, we employed high resolution imaging techniques such as SEM, Atomic Force Microscopy (AFM) and Confocal Raman Microscopy to elucidate the drug release process on these coatings in situ, indicating a correlation of release kinetics with coating morphology.
Dong
Jinping
J
Characterization Facility, Institute of Technology, University of Minnesota, 12 Shepherd Labs, 100 Union St SE, Minneapolis, MN 55455, USA. carena@vt.edu
Frethem
Chris
C
Haugstad
Greg
G
Hoerr
Robert A
RA
Foley
John D
JD
Matuszewski
Michael J
MJ
Puskas
Judit E
JE
D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004058:Diffusion; D004339:Drug Compounding / Q000379:methods; D008422:Materials Testing; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties
D020099:Coated Materials, Biocompatible; D053769:Nanocapsules; D004364:Pharmaceutical Preparations; D011108:Polymers