title: Breast-conserving surgery in 201 very young patients (<35 years).
abstract: BACKGROUND
  Surgical treatment of breast cancer in very young patients (<35 years) is still a matter of debate, since age is a predictive factor of local recurrence after breast conservation.
  
  
  METHODS
  We retrospectively evaluated outcome and prognostic factors of 201 consecutive patients treated with breast conservation followed by whole breast irradiation between 1997 and 2004 with special attention paid to local control. The average follow up was 72 months (range 13-133 months).
  
  
  RESULTS
  The mean age was 32 years (Range 20-34). Invasive ductal carcinoma was found in 175 (87.1%) patients. Two (1%) patients had invasive lobular carcinoma. One-hundred and eighteen patients (58.7%) had tumors of 2 cm or smaller. Sentinel lymph node biopsy was performed in 105 (52.2%) patients. One-hundred and ten (54.7%) patients had node-negative disease, 68 (33.8%) patients had 1-3 positive nodes and 23 (11.4%) +4 positive nodes. Eighteen patients (9.0%) developed a local recurrence, 25 (12.5%) developed distant metastases and 23 patients (11.4%) died during follow up. The 5- and 10-year cumulative incidence of local events were 8.2% and 12,3% respectively. The univariate analysis did not identify any variables affecting local disease-free survival.
  
  
  CONCLUSIONS
  Breast conservation in very young patients achieves an acceptable local control rate. No prognostic factors were associated with local events.
authors: Division of Breast Surgery, European Institute of Oncology, Via Ripamonti 435, Milan, Italy. oreste.gentilini@ieo.it
authors: Oreste
authors: O
authors: Gentilini
authors: Edoardo
authors: E
authors: Botteri
authors: Nicole
authors: N
authors: Rotmensz
authors: Antonio
authors: A
authors: Toesca
authors: Helio
authors: H
authors: De Oliveira
authors: Claudia
authors: C
authors: Sangalli
authors: Marco
authors: M
authors: Colleoni
authors: Mattia
authors: M
authors: Intra
authors: Viviana
authors: V
authors: Galimberti
authors: Paolo
authors: P
authors: Veronesi
authors: Alberto
authors: A
authors: Luini
authors: Umberto
authors: U
authors: Veronesi
mesh_terms: D000328:Adult; D000367:Age Factors; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D015412:Mastectomy, Segmental / Q000706:statistics & numerical data*; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy / Q000706:statistics & numerical data; D016896:Treatment Outcome; D016387:Women's Health; D055815:Young Adult