title: Methods to enhance laser speckle imaging of high-flow and low-flow vasculature.
abstract: The objective of this paper is to present two methods to extend the response range of laser speckle imaging (LSI). We report on the use of two methods (image exposure time control and magnetomotive actuation of exogenous contrast agents) to enhance characterization of high- and low-flow vasculature, respectively. With an exposure time of 10 and 0.01 ms, the linear response range extended to 10 and 280 mm/s, respectively. With application of an AC magnetic field to a solution of stagnant SPIO particles, an apparent increase of approximately 3x in speckle flow index was induced.
authors: Department of Biomedical Engineering, Beckman Laser Institute, University of California, Irvine, CA 92612, USA. choib@uci.edu
authors: Bernard
authors: B
authors: Choi
authors: Tyson L
authors: TL
authors: Ringold
authors: Jeehyun
authors: J
authors: Kim
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology; D003460:Crystallization; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007834:Lasers; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D019047:Phantoms, Imaging; D012039:Regional Blood Flow / Q000502:physiology; D013997:Time Factors
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide