title: Cramér-Rao bound analysis of echo time selection for (1)H-MR spectroscopy.
abstract: The choice of echo time (TE) is a complicated and controversial issue in proton MR spectroscopy, and represents a balancing act between signal-to-noise ratio and signal complexity. The TE values used in previous literature were selected either heuristically or based on limited empirical studies. In this work, we reconsider this problem from an estimation theoretic perspective. Specifically, we analyze the Crame r-Rao lower bound on estimated spectral parameters as a function of TE, which serves as a metric to quantify the reliability of the estimation procedure. This analysis reveals that a good choice of TE often depends on the particular metabolite of interest, and is a function of both the coupling properties of the metabolites and the general complexity of the spectrum.
authors: Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. hnguyen6@illinois.edu
authors: Hien M
authors: HM
authors: Nguyen
authors: Zhubin J
authors: ZJ
authors: Gahvari
authors: Justin P
authors: JP
authors: Haldar
authors: Minh N
authors: MN
authors: Do
authors: Zhi-Pei
authors: ZP
authors: Liang
mesh_terms: D000465:Algorithms; D001921:Brain / Q000378:metabolism; D001931:Brain Mapping / Q000379:methods*; D001330:Electronic Data Processing; D018698:Glutamic Acid / Q000737:chemistry; D005973:Glutamine / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D015233:Models, Statistical; D016011:Normal Distribution; D012815:Signal Processing, Computer-Assisted; D012984:Software; D013997:Time Factors
chemical_list: D005973:Glutamine; D018698:Glutamic Acid