title: The C-terminal portion of an archaeal toxin, aRelE, plays a crucial role in protein synthesis inhibition.
abstract: Mutations of amino acids in the C-terminal region of an archaeal toxin, aRelE, from Pyrococcus horikoshii were characterized with respect to protein synthesis inhibitory activity and 70S ribosome-binding activity. The results suggest that basic residues at the C-terminal region in aRelE play a crucial role both in 70S ribosome binding and in protein synthesis inhibition activities.
authors: Laboratory of Structural Biology, Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan.
authors: Chie
authors: C
authors: Kikutake
authors: Masaaki
authors: M
authors: Shinohara
authors: Hisanori
authors: H
authors: Takagi
authors: Takashi
authors: T
authors: Nakashima
authors: Makoto
authors: M
authors: Kimura
mesh_terms: D019943:Amino Acid Substitution; D019843:Archaeal Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism / Q000633:toxicity*; D008958:Models, Molecular; D014176:Protein Biosynthesis / Q000187:drug effects*; D011487:Protein Conformation; D043902:Pyrococcus horikoshii; D012270:Ribosomes / Q000378:metabolism; D014118:Toxins, Biological / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism / Q000633:toxicity*
chemical_list: D019843:Archaeal Proteins; D014118:Toxins, Biological