The Relationships Between Loss of Standard CD44 Expression and Lymph Node, Liver Metastasis in T3 Colorectal Carcinoma.
OBJECTIVE
The aim of the present study was to evaluate the standard CD44 (CD44s) expression in colorectal cancer (CRC) with invasion to the subserosal layer (T3), its relationship with clinicopathological characteristics, and its potential metastatic significance.


METHODS
CD44s expression was measured on immunohistochemistry in tumors from 65 patients with primary colorectal carcinomas. CD44s expression was estimated at the deepest invaded area of the tumor in subserosal layer.


RESULTS
CD44s was demonstrated in 35.4% (23/65). CD44s expression showed no significant relationship with the clinicopathological characteristics such as age, gender, tumor location, tumor size, and macroscopic/microscopic classification. However, the CD44s expression showed significantly adverse relationship with lymph node metastasis (p < 0.05) and liver metastasis (p < 0.01), respectively.


CONCLUSIONS
The loss of CD44s expression in cancer cells in the deepest invaded area is a good marker for predicting potential metastasis to lymph nodes and liver in T3 CRC.
Kunimura
Toshiaki
T
First Department of Pathology, Showa University School of Medicine, 5 Hatanodai-1, Shinagawa-ku, Tokyo 142-8666, Japan. kunimura@med.showa-u.ac.jp
Yoshida
Tomohiko
T
Sugiyama
Tomoko
T
Morohoshi
Toshio
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000378:metabolism* / Q000556:secondary*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis*; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000556:secondary*; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
D014408:Biomarkers, Tumor; D018960:Hyaluronan Receptors