title: CD9 gene variations are not associated with female infertility in humans.
abstract: OBJECTIVE
  To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans.
  
  
  METHODS
  We sequenced the entire coding region of this gene in 86 Japanese women with unexplained infertility and further conducted a case-control study of six tagging single nucleotide polymorphisms (SNPs) in this gene using an additional 164 samples obtained from a fertile control group.
  
  
  RESULTS
  No disease-causing mutation in the CD9 gene was evident in these samples and no significant association between the tagging SNPs and the studied cohort was identified.
  
  
  CONCLUSIONS
  Our findings do not support the hypothesis that genetic alterations of the CD9 gene cause female infertility in humans.
authors: Division of Molecular Genetics, Institute for Comprehensive Medical Science, Toyoake, Japan.
authors: Sachie
authors: S
authors: Nishiyama
authors: Taro
authors: T
authors: Kishi
authors: Takema
authors: T
authors: Kato
authors: Machiko
authors: M
authors: Suzuki
authors: Haruki
authors: H
authors: Nishizawa
authors: Kanako
authors: K
authors: Pryor-Koishi
authors: Tomio
authors: T
authors: Sawada
authors: Yukio
authors: Y
authors: Nishiyama
authors: Nakao
authors: N
authors: Iwata
authors: Yasuhiro
authors: Y
authors: Udagawa
authors: Hiroki
authors: H
authors: Kurahashi
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007247:Infertility, Female / Q000235:genetics*; D007564:Japan; D008562:Membrane Glycoproteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D060245:Tetraspanin 29
chemical_list: D015703:Antigens, CD; C554869:CD9 protein, human; D008562:Membrane Glycoproteins; D060245:Tetraspanin 29; D004247:DNA