Dehydroconicasterol and aurantoic acid, a chlorinated polyene derivative, from the Indonesian sponge Theonella swinhoei.
The chlorinated polyene aurantoic acid (1) and the 4-methylene sterol dehydroconicasterol (2) were isolated from the Indonesian sponge Theonella swinhoei, and their structures were elucidated by interpretation of spectroscopic data. Aurantoic acid is a unique member in the class of naturally occurring conjugated polyene derivatives, while dehydroconicasterol is the likely biogenetic precursor of the major Theonella 4-methylene sterols.
Angawi
Rihab F
RF
Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
Calcinai
Barbara
B
Cerrano
Carlo
C
Dien
Henny Adeleida
HA
Fattorusso
Ernesto
E
Scala
Fernando
F
Taglialatela-Scafati
Orazio
O
D000818:Animals; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification*; D047232:Theonella / Q000737:chemistry*
D011090:Polyenes; C546304:aurantoic acid; C546305:dehydroconicasterol; D002784:Cholesterol