Synthesis of N-succinyl-L,L-diaminopimelic acid mimetics via selective protection.
The search for potential inhibitors that target so far unexplored bacterial enzyme mono-N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) has stimulated a development of methodology for quick and efficient preparation of mono-N-acylated 2,6-diaminopimelic acid (DAP) derivatives bearing the different carboxyl groups or lipophilic moieties on their amino group.
Vanek
V
V
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
Pícha
J
J
Budesínský
M
M
Sanda
M
M
Jirácek
J
J
Holz
R C
RC
Hlavácek
J
J
D000215:Acylation; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D003960:Diaminopimelic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D053858:Metabolic Networks and Pathways; D008958:Models, Molecular; D021241:Spectrometry, Mass, Electrospray Ionization; D013386:Succinates / Q000138:chemical synthesis* / Q000737:chemistry; D051277:Succinyldiaminopimelate Transaminase / Q000037:antagonists & inhibitors / Q000378:metabolism
D013386:Succinates; D003960:Diaminopimelic Acid; D051277:Succinyldiaminopimelate Transaminase