title: Radionuclide imaging study of long-term pulmonary function after lobectomy in children with congenital cystic lung disease.
abstract: OBJECTIVE
  We evaluated the long-term pulmonary function after lobectomy for congenital cystic lung disease, in both infants and children, using radionuclide imaging (RI).
  
  
  METHODS
  We performed a retrospective review of 93 patients who underwent resection of cystic lung lesions between 1974 and 2001. The results of postoperative lung volume/perfusion scintigraphy at 1 (n = 64), 5 (n = 32), and 10 years (n = 18) after surgery (V1, 5, 10/Q1, 5, 10) and mean transit time (MTT-a marker for air-trapping) at 1, 5, and 10 years after surgery (MTT1, 5, 10) were compared with respect to age at operation, preoperative infection, underlying disease, and type of surgery.
  
  
  RESULTS
  Patients who were younger than 1 year at the time of surgery showed a significantly lower MTT5 (1.09 +/- 0.08) and MTT10 (1.15 +/- 0.11) than patients who were older than 1 year at the time of surgery (MTT5, 1.49 +/- 0.67; MTT10, 1.54 +/- 0.33). The noninfected group had significantly higher Q10 and lower MTT10 values (P < .05) compared to the infected group. No significant differences were observed between patients with single lobe vs multiple lobe resection.
  
  
  CONCLUSIONS
  The optimal age for surgery in patients with congenital cystic lung disease appears to be less than 1 year.
authors: Department of Surgery, Tokyo Metropolitan Kiyose Children's Hospital, Kiyose, Tokyo 204-8567, Japan.
authors: Koji
authors: K
authors: Komori
authors: Shoichiro
authors: S
authors: Kamagata
authors: Seiichi
authors: S
authors: Hirobe
authors: Miki
authors: M
authors: Toma
authors: Kenji
authors: K
authors: Okumura
authors: Mitsuru
authors: M
authors: Muto
authors: Shogo
authors: S
authors: Kasai
authors: Akira
authors: A
authors: Hayashi
authors: Mayumi
authors: M
authors: Suenaga
authors: Tomoo
authors: T
authors: Miyakawa
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D015615:Cystic Adenomatoid Malformation of Lung, Congenital / Q000601:surgery; D003560:Cysts / Q000151:congenital* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000002:abnormalities / Q000000981:diagnostic imaging* / Q000601:surgery; D008171:Lung Diseases / Q000151:congenital* / Q000601:surgery*; D008176:Lung Volume Measurements; D008297:Male; D011013:Pneumonectomy / Q000379:methods*; D011877:Radionuclide Imaging; D012129:Respiratory Function Tests / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes