title: Selective phenol hydrogenation to cyclohexanone over a dual supported Pd-Lewis acid catalyst.
abstract: Cyclohexanone is an industrially important intermediate in the synthesis of materials such as nylon, but preparing it efficiently through direct hydrogenation of phenol is hindered by over-reduction to cyclohexanol. Here we report that a previously unappreciated combination of two common commercial catalysts-nanoparticulate palladium (supported on carbon, alumina, or NaY zeolite) and a Lewis acid such as AlCl3-synergistically promotes this reaction. Conversion exceeding 99.9% was achieved with >99.9% selectivity within 7 hours at 1.0-megapascal hydrogen pressure and 50 degrees C. The reaction was accelerated at higher temperature or in a compressed CO(2) solvent medium. Preliminary kinetic and spectroscopic studies suggest that the Lewis acid sequentially enhances the hydrogenation of phenol to cyclohexanone and then inhibits further hydrogenation of the ketone.
authors: Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors: Huizhen
authors: H
authors: Liu
authors: Tao
authors: T
authors: Jiang
authors: Buxing
authors: B
authors: Han
authors: Shuguang
authors: S
authors: Liang
authors: Yinxi
authors: Y
authors: Zhou