Shock induced electrical activation in structurally detailed models of pig left-ventricular tissue.
Detailed models of sample specific structures in pig left-ventricular tissue have been constructed. These models include epicardial and endocardial surfaces, fiber and sheet orientations, vessels and cleavage planes with significant dimensions. This work shows that it is possible to extract from 3D tissue images reduced dimension descriptions of cleavage planes in the heart wall. These descriptions are used to analyze the response of tissue to electrical shocks of varying strengths. The presence of explicit discontinuities in the heart significantly reduces the time required for transmural activation and provides a basis for understanding successful defibrillation.
Trew
Mark L
ML
Auckland Bioengineering Institute, University of Auckland, New Zealand. m.trew@auckland.ac.nz
Ashton
Jesse L
JL
Caldwell
Bryan J
BJ
Smaill
Bruce H
BH
D000818:Animals; D004554:Electric Countershock / Q000379:methods*; D004594:Electrophysiology / Q000379:methods*; D004699:Endocardium / Q000473:pathology*; D006321:Heart / Q000502:physiology*; D006329:Heart Conduction System; D006352:Heart Ventricles / Q000473:pathology*; D021621:Imaging, Three-Dimensional; D008954:Models, Biological; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D010496:Pericardium / Q000473:pathology; D012769:Shock / Q000503:physiopathology*; D013552:Swine; D013997:Time Factors