title: Evidence for maternal transmission of scrapie in naturally affected flocks.
abstract: It has been known for many years that the offspring of scrapie affected ewes are at increased risk of developing scrapie but whether this is simply the result of an increased genetic susceptibility or transmission of infection has always been unclear. To contribute to clarify this we analysed the data collected in a detailed study of scrapie occurrence in a number of naturally affected commercial sheep flocks in Great Britain (GB) to investigate the association between PrP genotype and parental scrapie status and the incidence of scrapie. Our analyses confirmed the strong association between PrP genotype and the incidence of scrapie found in previous studies and a low incidence of scrapie in animals carrying the ARR allele and a high risk in homozygous VRQ animals. However, we also demonstrate an increased incidence of scrapie in the offspring of scrapie affected ewes controlling for the confounding effect of PrP genotype, but no increased scrapie incidence in the offspring of scrapie affected sires. Our results suggest that some of the increased incidence of scrapie in the offspring of scrapie affected ewes is the result of transmission of infection from mother to offspring. Our results confirm that a breeding policy aimed at decreasing the genetic susceptibility of the population should decrease the incidence of scrapie and that removing the offspring of scrapie affected animals from affected flocks could contribute to the control of this disease.
authors: Centre for Epidemiology and Risk Analysis, Veterinary Laboratories Agency, New Haw, Addlestone, Surrey KT15 3NB, UK. Lindahoinville@ntlworld.com
authors: Linda J
authors: LJ
authors: Hoinville
authors: Susan C
authors: SC
authors: Tongue
authors: John W
authors: JW
authors: Wilesmith
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D004198:Disease Susceptibility / Q000662:veterinary; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015994:Incidence; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control / Q000662:veterinary*; D008297:Male; D011247:Pregnancy; D011328:Prions / Q000235:genetics* / Q000276:immunology; D012307:Risk Factors; D012608:Scrapie / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control / Q000635:transmission*; D012756:Sheep; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D011328:Prions