title: Isotretinoin (13-cis-retinoic acid)-associated premature ventricular contractions.
abstract: Isotretinoin (13-cis-retinoic acid), a synthetic vitamin A derivative, is used to treat a wide variety of dermatologic conditions including severe acne. Isotretinoin can trigger premature ventricular contractions (PVCs). We describe a 17-year-old boy who presented with PVCs on electrocardiogram during isotretinoin (Roaccutane, Roche) treatment for nodular facial acne. Presence of documented PVCs -on electrocardiogram and Holter monitoring- and the disappearance of these PVCs after cessation of the treatment strongly suggest isotretinoin-related PVCs in our case. The impact of isotretinoin on ventricular rhythm can not be ruled out in our case as we have revealed the presence of the temporal association of isotretinoin and documented PVCs. Thus, clinicians should be aware of possible arrhythmogenic effect(s) of isotretinoin.
authors: Pediatric Cardiology Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors: Esra
authors: E
authors: Kiliç
authors: Murat
authors: M
authors: Sahin
authors: Sedef
authors: S
authors: Sahin
authors: Sema
authors: S
authors: Ozer
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D003879:Dermatologic Agents / Q000009:adverse effects*; D004562:Electrocardiography; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D008297:Male; D018879:Ventricular Premature Complexes / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin