Hypertension in aortic coarctation.
Patients with aortic coarctation are prone to develop arterial hypertension at various stages throughout life. There are at least three different pathophysiologic pathways: re-stenosis at the aortic isthmus, paradoxical hypertension, and late hypertension at long-term follow-up. As the most common causes of death reported for coarctation patients are linked to hypertension, it is important to differentiate these pathways of hypertension carefully to provide optimal treatment for hypertensive coarctation patients. This review summarizes the actual data about those different pathologic pathways, about how to differentiate them from each other, and how to treat them adequately.
Hager
A
A
Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Technische Universität München, Germany. a-hager@web.de
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001017:Aortic Coarctation / Q000145:classification / Q000150:complications* / Q000196:embryology / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology / Q000601:surgery; D001024:Aortic Valve Stenosis; D017704:Baroreflex / Q000502:physiology; D002318:Cardiovascular Diseases / Q000453:epidemiology; D004232:Diuretics / Q000627:therapeutic use; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000145:classification / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D007223:Infant; D008019:Life Style; D008279:Magnetic Resonance Imaging; D008297:Male; D012737:Sex Factors; D013997:Time Factors; D036542:Tomography, Spiral Computed
D000959:Antihypertensive Agents; D004232:Diuretics