Stress induced cognitive deficit is differentially modulated in BALB/c and C57Bl/6 mice: correlation with Th1/Th2 balance after stress exposure.
This work shows a comparative study on the effects of chronic mild stress upon learning and memory and immunity, in BALB/c and C57BL/6 mice. Stressed BALB/c, but not C57Bl/6 mice, showed a poor learning performance, morphological alterations in the hippocampus with an increase in oxidative stress. A correlation between poor memory performance and the increase of the Th2/Th1 balance was found. Our results suggest that vulnerability to cognitive deficit associated with stress exposition could be related to a differential regulation of Th1/Th2 cytokine balance, suggesting a better learning performance for individuals that produce Th1 type cytokine after stress exposition.
Palumbo
M L
ML
CEFYBO-CONICET, 1(a). Cátedra de Farmacología, Facultad de Medicina, UBA, 1121 Ciudad de Buenos Aires, Argentina.
Canzobre
M C
MC
Pascuan
C G
CG
Ríos
H
H
Wald
M
M
Genaro
A M
AM
D000818:Animals; D002469:Cell Separation; D003072:Cognition Disorders / Q000235:genetics / Q000276:immunology* / Q000523:psychology*; D016207:Cytokines / Q000276:immunology; D005434:Flow Cytometry; D020022:Genetic Predisposition to Disease; D006624:Hippocampus / Q000276:immunology / Q000473:pathology; D018782:Maze Learning; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress / Q000276:immunology; D017382:Reactive Oxygen Species / Q000276:immunology / Q000378:metabolism; D013315:Stress, Psychological / Q000235:genetics / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D016207:Cytokines; D017382:Reactive Oxygen Species