Cytotoxicity of natural compounds isolated from the seeds of Garcinia afzelii.
The new compounds guttiferone O ( 1) and 3-methoxycheffouxanthone ( 2) have been isolated from the seeds of Garcinia afzelii Engl., together with nine known compounds: 2-hydroxy-1,7-dimethoxyxanthone ( 3), smeathxanthone A ( 4), 1,5-dihydroxyxanthone ( 5), 1,6-dihydroxy-5-methoxyxanthone ( 6), cheffouxanthone ( 7), 1,3,5-trihydroxyxanthone ( 8), smeathxanthone B ( 9), isoxanthochymol ( 10) and guttiferone E ( 11). Their structures were elucidated by means of 1D and 2D-NMR techniques. All the isolates showed high cytotoxic activity and were found inactive when tested against HIV and influenza viruses.
Lannang
Alain Meli
AM
Department of Chemistry, Higher Teachers' Training College, University of Maroua, Maroua, Cameroon.
Louh
Gabin Nselapi
GN
Biloa
Bernadette Messi
BM
Komguem
Justin
J
Mbazoa
Celine Djama
CD
Sondengam
Beiban Luc
BL
Naesens
Lieve
L
Pannecouque
Christophe
C
De Clercq
Erik
E
Sayed El Ashry
El H
el H
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D000998:Antiviral Agents / Q000302:isolation & purification; D001577:Benzophenones / Q000302:isolation & purification*; D004353:Drug Evaluation, Preclinical; D029760:Garcinia / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D044004:Xanthones / Q000302:isolation & purification*
D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D001577:Benzophenones; D044004:Xanthones; C544371:guttiferone O