title: Inherited defects in pedigree dogs. Part 2: Disorders that are not related to breed standards.
abstract: Recent debate concerning health problems in pedigree animals has highlighted gaps in current knowledge of the prevalence, severity and welfare implications of deleterious inherited traits within the pedigree-dog population. In this second part of a two-part review, inherited disorders in the top 50 UK Kennel Club registered breeds were researched using systematic searches of existing databases. A set of inclusion and exclusion criteria, including an evidence strength scale (SEHB), were applied to search results. A total of 312 non-conformation linked inherited disorders was identified, with German shepherd dogs and Golden retrievers associated with the greatest number of disorders. The most commonly reported mode of inheritance was autosomal recessive (71%; 57 breed-disorder combinations), and the most common primarily affected body system was the nervous sensory system. To provide a true assessment of the scale of inherited disorders in the pedigree dogs studied more effort is required to collect accurate prevalence data.
authors: Department of Veterinary Clinical Sciences, Royal Veterinary College, UK.
authors: Jennifer F
authors: JF
authors: Summers
authors: Department of Veterinary Clinical Sciences, Royal Veterinary College, UK.
authors: Gillian
authors: G
authors: Diesel
authors: Department of Veterinary Clinical Sciences, Royal Veterinary College, UK.
authors: Lucy
authors: L
authors: Asher
authors: Faculty of Veterinary Science, University of Sydney, Australia.
authors: Paul D
authors: PD
authors: McGreevy
authors: Department of Veterinary Clinical Sciences, Royal Veterinary College, UK. Electronic address: lcollins@rvc.ac.uk.
authors: Lisa M
authors: LM
authors: Collins
mesh_terms: D000827:Animal Welfare; D000818:Animals; D001947:Breeding / Q000379:methods; D004283:Dog Diseases / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D004285:Dogs / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D007178:Inbreeding; D008297:Male; D010375:Pedigree; D015995:Prevalence; D012720:Severity of Illness Index