title: Olfactory bulb volume in Taiwanese patients with posttraumatic anosmia.
abstract: BACKGROUND
  Olfactory bulb (OB) volume has been shown to be an indicator of olfactory function. However, few studies have been done in Asia to investigate the influence of different disorders on OB volume.
  
  
  METHODS
  Data from patients with posttraumatic anosmia were collected in our department. Their olfactory thresholds were assessed by the phenyl ethyl alcohol threshold test. They were treated with a course of high-dose steroid, and followed up for at least 3 months without any olfactory improvement. Magnetic resonance imaging was subsequently used to measure patients' OB volumes. Subjects who self-reported their olfactory function was normal were also included in the control group for comparison.
  
  
  RESULTS
  Fifty-four patients with posttraumatic anosmia and 30 subjects who self-reported their olfactory function was normal were enrolled in this study. The mean right OB volume was 45.2 mm3, and the mean left OB volume was 46.3 mm3 in patients with posttraumatic anosmia. The mean right OB volume was 59.7 mm3, and the mean left OB volume was 66.0 mm3 in control subjects. The OB volumes were significantly lower in patients with posttraumatic anosmia.
  
  
  CONCLUSIONS
  OB volumes were significantly lower in Taiwanese patients with posttraumatic anosmia.
authors: Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan.
authors: Rong-San
authors: RS
authors: Jiang
authors: Jyh-Wen
authors: JW
authors: Chai
authors: Wen-Hsien
authors: WH
authors: Chen
authors: Wen-Bin
authors: WB
authors: Fuh
authors: Chin-Ming
authors: CM
authors: Chiang
authors: Clayton Chi-Chang
authors: CC
authors: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D006259:Craniocerebral Trauma / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D009830:Olfactory Bulb / Q000473:pathology*; D055696:Olfactory Perception; D009929:Organ Size; D012684:Sensory Thresholds; D013256:Steroids / Q000627:therapeutic use; D013624:Taiwan
chemical_list: D013256:Steroids