Putting the brakes on dietary fat breakdown.
Dietary lipid digestion is critical for body fat storage control, but little is known about the regulation of genes involved in fat breakdown and absorption in the gastrointestinal tract. A Drosophila study (Sieber and Thummel, 2009 [this issue of Cell Metabolism]) now demonstrates that the orphan nuclear receptor DHR96 adjusts fat storage in flies by tuning gastric lipase expression.
Kühnlein
Ronald P
RP
Department of Molecular Developmental Biology, Max-Planck-Institut für biophysikalische Chemie, 37077 Göttingen, Germany. rkuehnl@gwdg.de