title: Delta(9)-tetrahydrocannabinol enhances an increase of plasma corticosterone levels induced by forced swim-stress.
abstract: The present study was designed to determine the effect of delta(9)-tetrahydrocannabinol (THC) on susceptibility to stress. We reported that THC significantly prolonged the immobility time during the forced swim-stress. The selective cannabinoid CB(1) receptor antagonist O-2050 significantly reduced the enhancement of immobility by THC. We investigated the effect of THC on levels of stress hormone corticosterone under non-stress and forced swim-stress conditions. THC did not affect plasma corticosterone levels under non-stress conditions. However, THC, together with forced swim-stress, significantly increased plasma corticosterone levels. This effect was inhibited by O-2050. This evidence suggests that THC, under stressful conditions, enhances the susceptibility of the hypothalamus-pituitary-adrenal-axis to stress via the CB(1) receptor, thereby increasing the risk of depression.
authors: Advanced Materials Institute, Fukuoka University, 8-19-1 Nanakuma, Fukuoka, 814-0180, Japan.
authors: Kazunori
authors: K
authors: Sano
authors: Emi
authors: E
authors: Koushi
authors: Keiichi
authors: K
authors: Irie
authors: Sei
authors: S
authors: Higuchi
authors: Ryota
authors: R
authors: Tsuchihashi
authors: Junei
authors: J
authors: Kinjo
authors: Nobuaki
authors: N
authors: Egashira
authors: Ryozo
authors: R
authors: Oishi
authors: Naoki
authors: N
authors: Uchida
authors: Hiroshi
authors: H
authors: Nagai
authors: Ryoji
authors: R
authors: Nishimura
authors: Hiroyuki
authors: H
authors: Tanaka
authors: Satoshi
authors: S
authors: Morimoto
authors: Kenichi
authors: K
authors: Mishima
authors: Katsunori
authors: K
authors: Iwasaki
authors: Michihiro
authors: M
authors: Fujiwara
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003345:Corticosterone / Q000097:blood*; D013759:Dronabinol / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D051346:Mobility Limitation; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000378:metabolism*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D043884:Receptor, Cannabinoid, CB1 / Q000037:antagonists & inhibitors; D013312:Stress, Physiological / Q000187:drug effects*; D013550:Swimming
chemical_list: D011619:Psychotropic Drugs; D043884:Receptor, Cannabinoid, CB1; D013759:Dronabinol; D003345:Corticosterone