title: Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip.
abstract: Antitumor immunity plays an important role in the development of and protection against malignancy. In general, patients with cancer are known to be immunologically compromised. The objective of this study was to evaluate local immunity in squamous cell carcinomas (SCCs) of the tongue and lower lip by immunohistochemistry, using anti-CD3, -CD4, -CD8, -CD25 and -zeta antibodies. Immunoexpression at the invasive front was compared considering anatomical tumor location and metastasis. The CD4/CD8 ratio was calculated for each case and associated with the variables. CD3+, CD4+, CD8+ and CD25+ cell counts were higher in SCCs of the lower lip and anti-zeta immunostaining was more evident in non-metastatic cases. CD8+ and CD25+ cell counts were also significantly correlated with tumor location (p=0.004 and p=0.004, respectively), with the observation of a larger number of these cells in SCCs of the lower lip. The CD4/CD8 ratio showed no significant association with metastasis or anatomical location. In conclusion, the clinical behavior of the oral SCC cases studied might be partially related to the immunohistochemical profile of the inflammatory infiltrate present at the invasive front.
authors: Dentistry School, Federal University of Rio Grande do Norte, Natal-RN, Brazil. ericka_janine@yahoo.com.br
authors: Ericka Janine Dantas
authors: EJ
authors: da Silveira
authors: Márcia Cristina da Costa
authors: MC
authors: Miguel
authors: Kênio Costa
authors: KC
authors: Lima
authors: Roseana de Almeida
authors: Rde A
authors: Freitas
authors: Maria de Lourdes Silva Arruda
authors: Mde L
authors: de Morais
authors: Lélia Maria Guedes
authors: LM
authors: Queiroz
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D016516:CD4-CD8 Ratio; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000378:metabolism / Q000556:secondary; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008048:Lip Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D016131:Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014062:Tongue Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor