[Comparative estimation of efficiency and safety of racemic amlodipine and its S-enantiomer in hypertensive patients].
The authors conducted comparative estimation of efficiency and safety of racemic (R+S-) AMLODIPINE and sinistrorotatory isomer--S(-)AMLODIPINE besylate in 63 hypertensive patients from which 32 patients were administered (R+S-) amlodipine and 31--S(-)amlodipine besylate. It was established identity of antihypertensive effect according daily monitoring of blood pressure and monitoring of blood pressure in the office. However, daily dose of S(-)enantiomer was two times less than the dose of (R+S-) amlodipine. Adverse effects (headache, excessive heartbeat, peripheral edema) were less in patients who have received S(-)AMLODIPINE besylate that contributed to more expressed positive clinical dynamic of the state of patients of this group.
Sierkova
V K
VK
Kuz'minova
N V
NV
Alshantti
Iaser S Kh
IS
D000328:Adult; D017311:Amlodipine / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013237:Stereoisomerism; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D017311:Amlodipine