The preventive effect of mitomycin-C on the external auditory canal fibrosis in an experimentally induced animal model.
OBJECTIVE
The aim of this study was to investigate the preventive effect of mitomycin-C (MMC) on external auditory canal (EAC) fibrosis in an animal model.


METHODS
This is a randomized, controlled animal study.


METHODS
Sixteen guinea pigs were used for this study. After the skin of cartilaginous EAC was injured with an electrocautery, the cottonoid soaked in MMC solution with concentration of 0.4 mg/mL was topically applied for 5 minutes to the injured EAC in an MMC-treated group (n = 8). In addition, saline was applied in the control group (n = 8). At 4 weeks after injury, postsurgical changes of EAC were evaluated by histologic examination.


RESULTS
External auditory canal fibrosis was induced by injury with electrocautery. The MMC-treated group showed less degree of fibrosis without differences in epithelialization and inflammatory cell infiltration.


CONCLUSIONS
This study suggests that MMC can be helpful in preventing EAC fibrosis after injury.
Yoon
Yeo-Hoon
YH
Department of Otolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Park
Jae Yong
JY
Park
Yong Ho
YH
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D003251:Constriction, Pathologic / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D004195:Disease Models, Animal; D004424:Ear Canal / Q000473:pathology* / Q000601:surgery; D004564:Electrocoagulation; D005355:Fibrosis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D006168:Guinea Pigs; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use*; D014945:Wound Healing
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin