Hydrolase-catalyzed fast Henry reaction of nitroalkanes and aldehydes in organic media.
Nitroalkanes underwent fast additions to a variety of structurally diverse aldehydes under the catalysis of d-aminoacylase in DMSO. The influences of reaction conditions including solvents, temperature, enzyme concentration and molar ratio of substrates were systematically investigated. Seventeen products were obtained in short time with moderate to high yields. It is the first report on hydrolase-catalyzed fast Henry reaction in organic solvent.
Wang
Jun-Liang
JL
Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang, PR China.
Li
Xia
X
Xie
Hong-Yan
HY
Liu
Bo-Kai
BK
Lin
Xian-Fu
XF
D000447:Aldehydes / Q000378:metabolism*; D000473:Alkanes / Q000378:metabolism*; D001547:Benzaldehydes / Q000737:chemistry / Q000378:metabolism; D055162:Biocatalysis; D004980:Ethane / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D006867:Hydrolases / Q000378:metabolism*; D008956:Models, Chemical; D009574:Nitro Compounds / Q000378:metabolism*; D009595:Nitroparaffins / Q000737:chemistry / Q000378:metabolism; D012997:Solvents / Q000378:metabolism*; D013379:Substrate Specificity
D000447:Aldehydes; D000473:Alkanes; D001547:Benzaldehydes; D009574:Nitro Compounds; D009595:Nitroparaffins; D012997:Solvents; C029915:4-nitrobenzaldehyde; C014705:nitroethane; D006867:Hydrolases; D004980:Ethane