title: Third trimester fetal intracranial hemorrhage owing to vitamin K deficiency associated with hyperemesis gravidarum.
abstract: In rare cases, severe fetal vitamin K deficiency bleeding may occur in utero as a result of insufficient vitamin K placental transfer. We present a case of a 32-week-preterm infant born with severe intracranial hemorrhage to a pregnant woman who suffered from hyperemesis gravidarum. Neonatal hematologic status was compatible with vitamin K deficiency whereas the maternal coagulation function was normal. This case emphasizes the potential risk of fetal bleeding owing to vitamin K deficiency in pregnancies complicated with hyperemesis gravidarum. These women should be closely monitored and vitamin K prophylaxis might be considered.
authors: Department of Neonatology, Kaplan Medical Center, Rehovot and Hebrew University, Jerusalem, Israel.
authors: Smadar
authors: S
authors: Eventov-Friedman
authors: Gil
authors: G
authors: Klinger
authors: Eric S
authors: ES
authors: Shinwell
mesh_terms: D000328:Adult; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D005260:Female; D005315:Fetal Diseases / Q000209:etiology* / Q000517:prevention & control; D005865:Gestational Age; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000209:etiology* / Q000473:pathology; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D014812:Vitamin K / Q000627:therapeutic use; D014813:Vitamin K Deficiency / Q000209:etiology* / Q000517:prevention & control
chemical_list: D000933:Antifibrinolytic Agents; D014812:Vitamin K