8-OHdG in cerebrospinal fluid as a marker of oxidative stress in various neurodegenerative diseases.
BACKGROUND
The 8-hydroxy-2 deoxyguanosine (8-OHdG) is a product of nucleoside oxidation of DNA and a reliable marker of oxidative stress markers. Increased levels of oxidative stress have been reported in the cerebrospinal fluid (CSF) of patients with various neurodegenerative disorders.


OBJECTIVE
In search of a biochemical indicator of Parkinson's disease (PD), we analyzed the levels 8-OHdG in the CSF of 99 patients, using ELISA to assess the differences between various neurodegenerative disorders.


RESULTS
Statistically significant higher CSF levels (p = 0.022) of 8-OHdG in non-demented PD patients as compared to the control group were observed. No differences between CSF 8-OHdG levels and age at the time of lumbar puncture, presence or severity of dementia, or gender were found.


CONCLUSIONS
8-OHdG levels could be potentially useful in the neurochemically supported diagnosis of PD.
Gmitterová
K
K
Department of Neurology, Georg August University, DE-37075 Goettingen, Germany.
Heinemann
U
U
Gawinecka
J
J
Varges
D
D
Ciesielczyk
B
B
Valkovic
P
P
Benetin
J
J
Zerr
I
I
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000368:Aged; D000369:Aged, 80 and over; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000134:cerebrospinal fluid* / Q000145:classification / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology*; D012189:Retrospective Studies
D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine