Hemoperfusion with an immobilized polymyxin B fiber column decreases macrophage and monocyte activity.
We investigated whether direct hemoperfusion with a polymyxin B column (DHP-PMX) was able to decrease macrophage and monocyte activity in patients with sepsis. Nineteen patients with sepsis were enrolled in the study. They all had signs of systemic inflammatory response syndrome (SIRS) due to infection and a mean arterial blood pressure > or =65 mm Hg (irrespective of the use of catecholamines). A thermodilution catheter was inserted prior to DHP-PMX for intravenous infusion, and DHP-PMX was performed twice within 24 h for 3 h each time. Serum neopterin was measured four times: before DHP-PMX, and 24, 48, 72 h after it had begun. The serum concentrations of neopterin were 654 +/- 234 nmol/L prior to DHP-PMX vs. 573 +/- 196 nmol/L at 24 h, 452 +/- 161 nmol/L at 48 h, and 372 +/- 139 nmol/L at 72 h, showing a significant decrease from 48 h onwards compared with before treatment. These data suggest that DHP-PMX decreases macrophage and monocyte activity.
Kushi
Hidehiko
H
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, 1-8-13 Kanda, Surugadai, Chiyoda-ku, Tokyo 101-8306, Japan. hkushi@med.nihonu.ac.jp
Miki
Takahiro
T
Sakagami
Yuichiro
Y
Sato
Jun
J
Saito
Takeshi
T
Tanjoh
Katsuhisa
K
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D008264:Macrophages / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism; D019798:Neopterin / Q000097:blood*; D011112:Polymyxin B / Q000737:chemistry*; D011446:Prospective Studies; D018805:Sepsis / Q000628:therapy*; D013815:Thermodilution / Q000379:methods
D019798:Neopterin; D011112:Polymyxin B