Proteomics profile of cellular response to chiral drugs: prospects for pharmaceutical applications.
Chiral drugs account for a large proportion of drugs available in the market. There is increasing awareness of the importance of drug chirality and the role it plays in explaining the oftentimes dramatic differences in biological activities in the current drug development portfolio. Using recently developed chiral drugs-cell interaction system, several examples of protein profiles induced by chiral drugs were illustrated in detail on the platform of 2-D LC interfaced with MS/MS system. In addition, the background of chiral drug investigation from which contemporary drug chirality research has emerged, the techniques involved in proteomics technology, the application of proteomics in this exciting area, and the perspectives in future applications are also discussed.
Bun Ching
Chi
C
School of Chemical and Biomedical Engineering, College of Engineering, Nanyang Technological University, Singapore.
Zhang
Jianhua
J
Sui
Jianjun
J
Ning Chen
Wei
W
D000818:Animals; D002477:Cells / Q000378:metabolism; D002626:Chemistry, Pharmaceutical; D002853:Chromatography, Liquid; D015195:Drug Design; D006801:Humans; D008968:Molecular Conformation; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011506:Proteins / Q000187:drug effects* / Q000378:metabolism; D040901:Proteomics / Q000379:methods*; D053719:Tandem Mass Spectrometry
D004364:Pharmaceutical Preparations; D011506:Proteins