Flare-up of hand osteoarthritis caused by zoledronic acid infusion.
Zoledronic acid is effective for osteoporosis at a single annual intravenous dose. It usually causes few adverse effects; the most common are related to acute phase reactions. We reported the case of a 64-year-old woman who presented flare-up of hand osteoarthritis after zoledronic acid infusions. Despite the fact that arthralgia is a common side effect of intravenous bisphosphonates, development of inflammatory signs in osteoarthritic joints is a rare event. We hypothesized that this side effect is caused by a release of cytokines secondary to activation of gamma-delta T lymphocytes.
Werner de Castro
G R
GR
Rheumatology Unit, Hospital Governador Celso Ramos, Florianópolis, Brazil. castrogrwc@gmail.com
Neves
F S
FS
de Magalhães Souza Fialho
S C
SC
Pereira
I A
IA
Ribeiro
G
G
Zimmermann
A F
AF
D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D050823:Hand Joints; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D008875:Middle Aged; D010003:Osteoarthritis / Q000139:chemically induced*; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy; D000077211:Zoledronic Acid
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid