title: Comparing eccentric resistance exercise in prostate cancer survivors on and off hormone therapy: a pilot study.
abstract: OBJECTIVE
  To determine the feasibility of an eccentric resistance exercise training protocol in men with prostate cancer and to assess whether men with prostate cancer who are receiving androgen deprivation therapy (ADT) have a blunted effect from the training as compared with prostate cancer survivors not receiving ADT.
  
  
  METHODS
  Prospective pilot study.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  Sixteen men with prostate cancer (Gleason scores 3+3 to 4+4) were initially enrolled. Ten men (mean age 66, range 48-86) completed the study, 5 were currently receiving ADT. Analysis was performed on these 10 men.
  
  
  METHODS
  Subjects were evaluated at baseline. All men underwent a 12-week resistance exercise training protocol using a recumbent, high-force eccentric, leg cycle ergometer 3 times per week at a "somewhat hard" perceived exertion for 12 to 15 minutes. Preexercise and postexercise training changes were examined within and between groups.
  
  
  METHODS
  Quadriceps muscle volume (magnetic resonance imaging), isometric knee extension strength, functional mobility (Timed Up and Go Test [TUG] and 6-minute walk [6MW]), health-related quality of life (FACT-P), and fatigue (FACIT-fatigue scale).
  
  
  RESULTS
  The ADT group demonstrated significant within-group improvements in the 6MW (P = .01) and isometric knee extension strength (P = .03). This group also demonstrated a clinically relevant change in the FACT-P; however, this did not meet statistical significance. The non-ADT group demonstrated significant within-group improvements in the physical subscale of the FACT-P (P = .03) and an increase in muscle volume (P = .04). Their improvements in the TUG approached significance (P = .08). No between-group differences existed.
  
  
  CONCLUSIONS
  Eccentric resistance exercise was well tolerated, and both groups derived some benefits in strength and functional mobility. Men receiving ADT did not appear to have a blunted response to the exercise as compared with prostate cancer survivors not receiving ADT.
authors: Department of Physical Medicine and Rehabilitation, University of Utah and Huntsman Cancer Hospital, 590 Wakara Way, Salt Lake City, UT 84108, USA. pamela.hansen@hsc.utah.edu
authors: Pamela A
authors: PA
authors: Hansen
authors: Christopher B
authors: CB
authors: Dechet
authors: Christina A
authors: CA
authors: Porucznik
authors: Paul C
authors: PC
authors: LaStayo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000008:administration & dosage*; D005240:Feasibility Studies; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018763:Muscle Fatigue / Q000502:physiology; D053580:Muscle Strength / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology; D010865:Pilot Projects; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000534:rehabilitation*; D011788:Quality of Life; D055070:Resistance Training / Q000379:methods*; D011795:Surveys and Questionnaires; D017741:Survivors; D016896:Treatment Outcome
chemical_list: D000726:Androgen Antagonists