title: Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis.
abstract: A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide 17 which exhibited low micromolar inhibitory potency against T. brucei and selectivity towards both malaria and mammalian cells.
authors: St Jude Children's Hospital, Department of Chemical Biology and Therapeutics, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA.
authors: Jong Yeon
authors: JY
authors: Hwang
authors: David
authors: D
authors: Smithson
authors: Michele
authors: M
authors: Connelly
authors: Julie
authors: J
authors: Maier
authors: Fangyi
authors: F
authors: Zhu
authors: Kiplin R
authors: KR
authors: Guy
mesh_terms: D001549:Benzamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D055808:Drug Discovery; D006801:Humans; D021261:Parasitic Sensitivity Tests; D014344:Trypanocidal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D014346:Trypanosoma brucei brucei / Q000187:drug effects; D014353:Trypanosomiasis, African / Q000188:drug therapy
chemical_list: C549132:2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide; D001549:Benzamides; D014344:Trypanocidal Agents