title: Cobalt-catalyzed regioselective synthesis of pyrrolidinone derivatives by reductive coupling of nitriles and acrylamides.
abstract: A convenient and highly regioselective method for the synthesis of 5-methylenepyrrolidinone derivatives from various nitriles and acrylamides via a cobalt-catalyzed reductive coupling reaction is described. A possible mechanism that involves the formation of a cobaltaazacyclopentene intermediate from nitrile and acrylamide, protonation, keto-amide cyclization, and dehydration is proposed.
authors: Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors: Ying-Chieh
authors: YC
authors: Wong
authors: Kanniyappan
authors: K
authors: Parthasarathy
authors: Chien-Hong
authors: CH
authors: Cheng