title: Treatment of late-life depression alleviates caregiver burden.
abstract: OBJECTIVE
  To describe the burden experienced by family caregivers of older adults with depression and to examine the positive effects on caregivers of treating late-life depression.
  
  
  METHODS
  Two-phase treatment study for major depressive disorder (MDD) that included 6 weeks of open treatment with antidepressant medication for all older patients followed by 16 weeks of randomized treatment for patients who were partial responders, comparing a combination of medication and interpersonal psychotherapy with medication alone.
  
  
  METHODS
  Primary care and university late-life mental health research clinic.
  
  
  METHODS
  Adults aged 60 and older participating in a randomized trial for treatment of MDD who enrolled in a family caregiver study and their caregiver (N=244 dyads).
  
  
  METHODS
  Improvement in patient symptoms during open treatment (lower scores on the Hamilton Rating Scale for Depression (HRSD)) and remission of depression during randomized treatment (3 consecutive weekly HRSD scores of < or =7) were examined as predictors of lower general caregiver burden and burden specific to patient depression.
  
  
  RESULTS
  Caregivers reported a moderate to high level of general caregiver burden on average. Change in patient depression during open treatment was associated with significantly decreased depression-specific burden (beta=-0.22, P=.001) and a trend toward lower general burden (beta=-0.08, P=.08). Caregivers of patients who remitted showed significantly decreased depression-specific burden (F (1,76)=4.27, P=.04).
  
  
  CONCLUSIONS
  Treatment of late-life depression has benefits that extend to the family members on whom patients depend. Caregiver education and support may strengthen these effects.
authors: Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA. Martire@pitt.edu
authors: Lynn M
authors: LM
authors: Martire
authors: Richard
authors: R
authors: Schulz
authors: Charles F
authors: CF
authors: Reynolds
authors: Jordan F
authors: JF
authors: Karp
authors: Ariel G
authors: AG
authors: Gildengers
authors: Ellen M
authors: EM
authors: Whyte
mesh_terms: D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D017028:Caregivers; D017281:Cost of Illness; D003863:Depression / Q000628:therapy*; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D011613:Psychotherapy
chemical_list: D000928:Antidepressive Agents