title: In vitro adhesion measurements between skin and micropatterned poly(dimethylsiloxane) surfaces.
abstract: Micropatterned adhesive surfaces may have potential in reconstructive surgery. The adhesion performance of mice ear skin to micropatterned poly(dimethylsiloxane) (PDMS) was investigated, under in vitro conditions, and compared to flat substrates. No significant difference in separation force F was observed between flat substrates and micropatterned surfaces with pillar arrays. However, the energy necessary for separation of the substrate from the skin was sensitive to the topography. Furthermore, our results show that the force-displacement curves depended on the wetness of the skin: Highest force values were obtained for fresh skin while the forces decreased as the skin dried out. The results are encouraging for further studies on the potential of patterned PDMS in biomedical applications.
authors: INM, Leibniz-Institut für Neue Materialien gGmbH, Campus D2, 2D-66123 Saarbrücken, Germany. emersonjose.desouza@inm-gmbh.de
authors: E J
authors: EJ
authors: De Souza
authors: M
authors: M
authors: Kamperman
authors: G
authors: G
authors: Castellanos
authors: E
authors: E
authors: Kroner
authors: V
authors: V
authors: Armbruester
authors: M S
authors: MS
authors: Romann
authors: B
authors: B
authors: Schick
authors: E
authors: E
authors: Arzt
mesh_terms: D000268:Adhesiveness; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D019544:Equipment Failure Analysis; D008422:Materials Testing; D051379:Mice; D009757:Nylons / Q000737:chemistry*; D011474:Prosthesis Design; D012879:Skin Physiological Phenomena; D017768:Skin, Artificial; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D009757:Nylons; C085707:poly(dimethylsiloxane)-polyamide copolymer