title: Automated control of blood glucose in the OR and surgical ICU.
abstract: A device which integrates existing intravenous continuous glucose monitors and infusion pumps into a central hub for automated intravenous intensive insulin therapy, targeting non-diabetic critically-ill patients is presented. Additionally, a fuzzy logic based controller that is capable of automatically making closed-loop decisions to achieve tight glycemic control between a euglycemic range of 90 to 120 mg/dl is presented. Initial bench top testing shows a significant improvement in glycemic control with fuzzy logic control when compared to manual infusion protocols currently used in hospitals; future animal testing will be performed to verify these results in vivo.
authors: Johns Hopkins University Department of Biomedical Engineering and The Johns Hopkins Bayview Medical Center Department of Surgery, Baltimore, MD 21218, USA. jason.hsu@jhu.edu
authors: Jason J
authors: JJ
authors: Hsu
authors: Joseph I
authors: JI
authors: Wang
authors: Amy
authors: A
authors: Lee
authors: Daniel Y
authors: DY
authors: Li
authors: Charlotte H
authors: CH
authors: Chen
authors: Stephanie
authors: S
authors: Huang
authors: Alex
authors: A
authors: Liu
authors: Bo-Kyung
authors: BK
authors: Yoon
authors: Sang-Keun
authors: SK
authors: Kim
authors: Tsung-Jui
authors: TJ
authors: Tsai
mesh_terms: D001331:Automation; D001698:Biomedical Engineering; D001774:Blood Chemical Analysis / Q000379:methods*; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D020000:Decision Support Systems, Clinical; D017143:Fuzzy Logic; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage; D007332:Insulin Infusion Systems; D007362:Intensive Care Units; D008991:Monitoring, Physiologic / Q000379:methods*; D009873:Operating Rooms
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin