Nanoparticle enhanced thermal therapies.
Thermal therapies such as hyperthermia, radiofrequency ablation, cryoablation, etc. have shown great potential and are gaining increasing clinical acceptance in the treatment of solid tumors. However, these treatment modalities are limited by the size of tumor that can be treated, incomplete tumor kill, and damage to adjacent normal tissues. To address these limitations, the concept of adjuvant-assisted thermal therapies has been proposed and tested to enhance the tumor destructive effects of thermal therapies. CYT-6091, a pegylated colloidal gold nanoparticle containing TNF-alpha bound to its surface, has been extensively investigated in our lab as an adjuvant to enhance thermal therapies. This paper describes our investigations of nanoparticle enhanced thermal therapies in various preclinical and translational models of solid tumors.
Shenoi
Mithun M
MM
Biomedical Engineering Department, University of Minnesota, Minneapolis, MN 55455 USA. mshenoi@umn.edu
Anderson
J
J
Bischof
John C
JC
D000818:Animals; D005260:Female; D005354:Fibrosarcoma / Q000628:therapy; D017979:Gold Colloid / Q000627:therapeutic use*; D006979:Hyperthermia, Induced; D008325:Mammary Neoplasms, Experimental / Q000628:therapy; D051379:Mice; D008805:Mice, Inbred A; D053758:Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000628:therapy; D012513:Sarcoma, Experimental / Q000628:therapy; D014409:Tumor Necrosis Factor-alpha / Q000627:therapeutic use
D017979:Gold Colloid; D014409:Tumor Necrosis Factor-alpha