A selective 'Off-On' fluorescent sensor for Zn(2+) based on hydrazone-pyrene derivative and its application for imaging of intracellular Zn(2+).
A simple and effective fluorescent sensor based on hydrazone-pyrene has been synthesized. This probe displays a highly selective fluorescent enhancement with Zn(2+), and application of this probe to detect the intrinsic Zn(2+) ions present in pancreatic beta-cells was successfully demonstrated.
Zhou
Ying
Y
Department of Chemistry and Nano Science Ewha Womans University, Seoul 120-750, Republic of Korea.
Kim
Ha Na
HN
Yoon
Juyoung
J
D045744:Cell Line, Tumor; D003952:Diagnostic Imaging; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D050417:Insulin-Secreting Cells / Q000378:metabolism; D010569:Perylene / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011721:Pyrenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013050:Spectrometry, Fluorescence; D015032:Zinc / Q000737:chemistry*
D005456:Fluorescent Dyes; D006835:Hydrazones; D011721:Pyrenes; D010569:Perylene; D015032:Zinc