title: Modeling and simulation of ion channels and action potentials in taste receptor cells.
abstract: Based on patch clamp data on the ionic currents of rat taste receptor cells, a mathematical model of mammalian taste receptor cells was constructed to simulate the action potentials of taste receptor cells and their corresponding ionic components, including voltage-gated Na(+) currents and outward delayed rectifier K(+) currents. Our simulations reproduced the action potentials of taste receptor cells in response to electrical stimuli or sour tastants. The kinetics of ion channels and their roles in action potentials of taste receptor cells were also analyzed. Our prototype model of single taste receptor cell and simulation results presented in this paper provide the basis for the further study of taste information processing in the gustatory system.
authors: Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China.
authors: PeiHua
authors: P
authors: Chen
authors: Xiao-dong
authors: XD
authors: Liu
authors: Wei
authors: W
authors: Zhang
authors: Jun
authors: J
authors: Zhou
authors: Ping
authors: P
authors: Wang
authors: Wei
authors: W
authors: Yang
authors: JianHong
authors: J
authors: Luo
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D015640:Ion Channel Gating / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D008959:Models, Neurological; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000378:metabolism*; D051381:Rats; D015222:Sodium Channels / Q000378:metabolism*; D013649:Taste / Q000502:physiology; D013650:Taste Buds / Q000166:cytology / Q000502:physiology
chemical_list: D015221:Potassium Channels; D015222:Sodium Channels