title: Speckle myocardial imaging modalities for early detection of myocardial impairment in isolated left ventricular non-compaction.
abstract: OBJECTIVE
  To examine the hypothesis that speckle myocardial imaging (SMI) modalities, including longitudinal, radial and circumferential systolic (s) and diastolic (d) myocardial velocity imaging, displacement (D), strain rate (SR) and strain (S), as well as left ventricular (LV) rotation/torsion are sensitive for detecting early myocardial dysfunction in isolated LV non-compaction (iLVNC).
  
  
  RESULTS
  Twenty patients with iLVNC diagnosed by cardiac magnetic resonance (15) or echocardiography (5) were included. Patients were divided into two groups: ejection fraction (EF)>50% (n=10) and EF<or=50% (n=10). Standard measures of systolic and diastolic function including pulsed wave tissue Doppler Imaging (PWTDI) were obtained. Longitudinal, radial and circumferential SMI, and LV rotation/torsion were compared with values for 20 age/sex-matched controls. EF, PWTDI E', E/E' and all of the SMI modalities were significantly abnormal for patients with EF<or=50% compared with controls. In contrast, EF and PWTDI E', E/E' were not significantly different between controls and patients with iLVNC (EF>50%). However, SMI-derived longitudinal sS, sSR, sD and radial sS, as well as LV rotation/torsion values, were all reduced in iLVNC (EF>50%) compared with controls. Measurements with the highest discriminating power between iLVNC (EF>50%) and controls were longitudinal sS mean of the six apical segments (area under the curve (AUC)=0.94), sS global average (AUC=0.94), LV rotation apical mean (AUC=0.94); LV torsion (AUC=0.93) LV torsion rate (AUC=0.94).
  
  
  CONCLUSIONS
  LV SMI values are reduced in patients with iLVNC, even those with normal EF and PWTDI. The most accurate SMI modalities to discriminate between patients and controls are longitudinal sS mean of the six apical segments, LV apical rotation or LV torsion rate.
authors: Cardiovascular Division, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
authors: Diego
authors: D
authors: Bellavia
authors: Hector I
authors: HI
authors: Michelena
authors: Matthew
authors: M
authors: Martinez
authors: Patricia A
authors: PA
authors: Pellikka
authors: Charles J
authors: CJ
authors: Bruce
authors: Heidi M
authors: HM
authors: Connolly
authors: Hector R
authors: HR
authors: Villarraga
authors: Gabriella
authors: G
authors: Veress
authors: Jae K
authors: JK
authors: Oh
authors: Fletcher A
authors: FA
authors: Miller
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D056830:Isolated Noncompaction of the Ventricular Myocardium / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results; D013318:Stroke Volume; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology; D055815:Young Adult