title: Tetraazaindenes derived from dihydropyrazines with DNA strand-breaking activity.
abstract: Dihydropyrazines (DHPs), which exhibit DNA strand-breaking activity and other biological activities associated with the generation of radical species, reacted with thiourea to give tetraazaindene (TAI) derivatives, despite thiourea is a well known radical scavenger. The structural determination of the TAIs was carried out and formation mechanism of TAI was investigated.
authors: Sojo University, Kumamoto, Japan.
authors: Kazuhide
authors: K
authors: Nakahara
authors: Shinji
authors: S
authors: Takechi
authors: Koki
authors: K
authors: Yamaguchi
authors: Kazunobu
authors: K
authors: Harano
authors: Tadatoshi
authors: T
authors: Yamaguchi
mesh_terms: D004249:DNA Damage / Q000187:drug effects*; D004925:Escherichia / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D011719:Pyrazines / Q000737:chemistry* / Q000494:pharmacology; D013778:Tetrazolium Salts / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D011719:Pyrazines; D013778:Tetrazolium Salts