[Estimation of diagnostic value of the middle cerebral artery peak systolic velocity in prediction of fetal anemia in pregnancies complicated by alloimmunisation].
The use of the middle cerebral artery peak systolic velocity (PSV) for the noninvasive diagnosis of fetal anemia in pregnancies complicated by alloimmunisation has the potential to reduce the number of invasive procedures.


OBJECTIVE
The study was undertaken to determine the detection of fetal anemia by fetal middle cerebral artery peak systolic velocity (MCA PSV).


METHODS
31 fetuses with red cell alloimmunisation were evaluated with Doppler ultrasongraphy. On the basis of ROC (AUC) analysis the cutoff point of MoM=1.215 with the highest sensitivity and specificity was established. We examined the relation between MoM=1.215 and neonatal hemoglobin level and the maternal antibody titre in the indirect antiglobulin test. Sensitivity specificity positive and negative value and statistical significance were calculated.


CONCLUSIONS
Data reported to date suggest that a threshold of 1.215 multiples of the median can be used to better diagnostic of fetal anemia.
Engel
Karina
K
Klinika Medycyny Matczyno Płodowej i Ginekologii PAM w Szczecinie. ronin@sci.pam.szczecin.pl
Kwiatek
Monika
M
Kłosowska
Magdalena
M
Bilar
Marek
M
Konefał
Halina
H
Orzińska
Agnieszka
A
Ronin-Walknowska
Elzbieta
E
D000740:Anemia / Q000097:blood / Q000000981:diagnostic imaging*; D001783:Blood Flow Velocity; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D005315:Fetal Diseases / Q000097:blood / Q000000981:diagnostic imaging*; D006801:Humans; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000000981:diagnostic imaging* / Q000276:immunology; D012372:ROC Curve; D012016:Reference Values; D018617:Ultrasonography, Doppler, Pulsed / Q000379:methods; D016216:Ultrasonography, Prenatal / Q000379:methods