Design and evaluation of novel polyanhydride blends as nerve guidance conduits.
Implantable biodegradable nerve guidance conduits (NGCs) have the potential to align and support regenerating cells, as well as prevent scar formation. In this study in vitro bioassays and in vivo material evaluations were performed using a nerve guidance conduit material made from a novel polyanhydride blend. In vitro cytotoxicity studies with both fibroblasts and primary chick neurons demonstrated that the proposed polyanhydride blend was non-cytotoxic. Subcutaneous implantation for 7days in rats resulted in an initial fibrin matrix, minimal macrophage presence and angiogenesis in the surrounding tissues. Nerve guidance conduits fabricated from the proposed polyanhydride blend material may serve as favorable biocompatible tissue engineering devices.
Griffin
Jeremy
J
Department of Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ 08854, USA.
Carbone
Ashley
A
Delgado-Rivera
Roberto
R
Meiners
Sally
S
Uhrich
Kathryn E
KE
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D004867:Equipment Design; D005260:Female; D048091:Guided Tissue Regeneration / Q000295:instrumentation* / Q000379:methods*; D008422:Materials Testing; D009416:Nerve Regeneration / Q000502:physiology*; D010525:Peripheral Nerves / Q000254:growth & development*; D049388:Polyanhydrides / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D054457:Tissue Scaffolds
D001672:Biocompatible Materials; D049388:Polyanhydrides