Fungal BRCA2 ortholog Brh2 brings 5' end strand invasion back on stage.
In this issue of Molecular Cell, Mazloum and Holloman (2009b) propose that 5' end strand invasion promoted by collaboration between Rad51 and Brh2 could be used for bypassing lesions during DNA replication, potentially advancing understanding of BRCA2 tumor suppressor function.
Llorente
Bertrand
B
CNRS, Unité Propre de Recherche, Laboratory of Genome Instability and Carcinogenesis, conventionné par l'Université d'Aix-Marseille, France. bllorente@ifr88.cnrs-mrs.fr
Modesti
Mauro
M
D024682:BRCA2 Protein / Q000737:chemistry / Q000378:metabolism*; D004271:DNA, Fungal / Q000737:chemistry / Q000378:metabolism*; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D051135:Rad51 Recombinase / Q000378:metabolism; D011995:Recombination, Genetic; D017386:Sequence Homology, Amino Acid; D014588:Ustilago / Q000235:genetics*
D024682:BRCA2 Protein; D004271:DNA, Fungal; D005656:Fungal Proteins; D051135:Rad51 Recombinase