Catalytic enantioselective formation of chiral-bridged dienes which are themselves ligands for enantioselective catalysis.
This paper reports a method for highly enantioselective Diels-Alder reaction with an acetylene equivalent to produce chiral-bridged dienes. These dienes, by coordination to Rh(I), can serve as catalysts for the enantioselective addition of vinyl or aryl groups to alpha,beta-unsaturated ketones.
Brown
M Kevin
MK
Department of Chemistry and Chemical Biology, Harvard Univeristy, Cambdrige, Massachusetts 02138, USA.
Corey
E J
EJ
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D013237:Stereoisomerism
D000475:Alkenes; D007659:Ketones; D008024:Ligands