title: [A case of 5-fluorouracil-induced hyperammmonia after chemotherapy for metastatic colon cancer].
abstract: A 79-year-old woman with colon cancer and multiple liver metastases was admitted to our hospital for systemic chemotherapy. She underwent first cycle of modified FOLFOX6 chemotherapy. She was confused on treatment day 5. Blood test revealed her serum ammonia level to be 121 microg/dl. We diagnosed 5-fluorouracil (5FU)-induced hyperammonemia. Conservative treatment resulted in improvement of metal status. The reason for hyperammonemia after administration of 5FU was the excess production of ammonium from metabolites of 5FU.
authors: Department of Internal Medicine, Okinawa Red Cross Hospital, Japan. mnakamura2@jin-aikai.or.jp
authors: Masamoto
authors: M
authors: Nakamura
authors: Kasen
authors: K
authors: Kobashikawa
authors: Jiro
authors: J
authors: Tamura
authors: Ryo
authors: R
authors: Takaki
authors: Masaru
authors: M
authors: Ohshiro
authors: Ryoji
authors: R
authors: Matayoshi
authors: Tetsuo
authors: T
authors: Hirata
authors: Fukunori
authors: F
authors: Kinjyo
authors: Jiro
authors: J
authors: Fujita
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D003110:Colonic Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D022124:Hyperammonemia / Q000139:chemically induced*; D002955:Leucovorin / Q000009:adverse effects; D008113:Liver Neoplasms / Q000556:secondary; D009944:Organoplatinum Compounds / Q000009:adverse effects
chemical_list: D000964:Antimetabolites, Antineoplastic; D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil