title: Prevention of steatosis by hepatic JNK1.
abstract: Nonalcoholic steatosis (fatty liver) is a major cause of liver dysfunction that is associated with insulin resistance and metabolic syndrome. The cJun NH(2)-terminal kinase 1 (JNK1) signaling pathway is implicated in the pathogenesis of hepatic steatosis and drugs that target JNK1 may be useful for treatment of this disease. Indeed, mice with defects in JNK1 expression in adipose tissue are protected against hepatic steatosis. Here we report that mice with specific ablation of Jnk1 in hepatocytes exhibit glucose intolerance, insulin resistance, and hepatic steatosis. JNK1 therefore serves opposing actions in liver and adipose tissue to both promote and prevent hepatic steatosis. This finding has potential implications for the design of JNK1-selective drugs for the treatment of metabolic syndrome.
authors: Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA.
authors: Guadalupe
authors: G
authors: Sabio
authors: Julie
authors: J
authors: Cavanagh-Kyros
authors: Hwi Jin
authors: HJ
authors: Ko
authors: Dae Young
authors: DY
authors: Jung
authors: Susan
authors: S
authors: Gray
authors: John Y
authors: JY
authors: Jun
authors: Tamera
authors: T
authors: Barrett
authors: Alfonso
authors: A
authors: Mora
authors: Jason K
authors: JK
authors: Kim
authors: Roger J
authors: RJ
authors: Davis
mesh_terms: D000818:Animals; D005234:Fatty Liver / Q000378:metabolism*; D018149:Glucose Intolerance / Q000378:metabolism*; D022781:Hepatocytes / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D048055:Mitogen-Activated Protein Kinase 8 / Q000235:genetics* / Q000378:metabolism*; D009928:Organ Specificity; D015398:Signal Transduction / Q000502:physiology
chemical_list: D048055:Mitogen-Activated Protein Kinase 8