Efficient synthesis of functionalized aziridinium salts.
Various aziridinium salts were efficiently prepared from bromination of a series of backbone substituted N,N-bisubstituted beta-amino alcohols and isolated via flash column chromatography. The effect of C-substitution, N-substitution, solvent, leaving group, and counteranions on formation of the isolable aziridinium salts was investigated.
Chong
Hyun-Soon
HS
Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, Chicago, Illinois 60616, USA. chong@iit.edu
Song
Hyun A
HA
Dadwal
Mamta
M
Sun
Xiang
X
Sin
Inseok
I
Chen
Yunwei
Y
D000605:Amino Alcohols / Q000737:chemistry*; D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012492:Salts / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents; D013237:Stereoisomerism
D000605:Amino Alcohols; D001388:Aziridines; D007202:Indicators and Reagents; D012492:Salts; D012997:Solvents