title: Bionic autonomic neuromodulation revolutionizes cardiology in the 21st century.
abstract: In this invited session, we would like to address the impact of bionic neuromodulation on cardiovascular diseases. It has been well established that cardiovascular dysregulation plays major roles in the pathogenesis of cardiovascular diseases. This is the reason why most drugs currently used in cardiology have significant pharmacological effects on the cardiovascular regulatory system. Since the ultimate center for cardiovascular regulation is the brainstem, it is conceivable that autonomic neuromodulation would have significant impacts on cardiovascular diseases. On the basis of this framework, we first developed a bionic, neurally regulated artificial pacemaker. We then substituted the brainstem by CPU and developed a bionic artificial baroreflex system. We further developed a bionic brain that achieved better regulatory conditions than the native brainstem in order to improve survival in animal model with heart failure. We recently developed a bionic neuromodulation system to reduce infarction size following acute myocardial infarction. We believe that the bionic neuromodulation will inspire even more intricate applications in cardiology in the 21(st) century.
authors: Kenji
authors: K
authors: Sunagawa
mesh_terms: D001701:Bionics / Q000379:methods / Q000639:trends; D002309:Cardiology / Q000379:methods* / Q000639:trends*; D002320:Cardiovascular Physiological Phenomena; D004599:Electric Stimulation Therapy / Q000379:methods* / Q000639:trends; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy; D006706:Homeostasis; D006801:Humans; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000628:therapy