title: A stiff blow from the stroma: collagen crosslinking drives tumor progression.
abstract: Matrix stiffness is an important microenvironmental cue that regulates cell growth, motility, and differentiation. In a recent Cell report, Weaver and colleagues implicate lysyl-oxidase-mediated collagen crosslinking as a contributor to tumor matrix stiffening, which leads to enhanced integrin signaling and invasive behavior in tumors.
authors: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
authors: Mei Rosa
authors: MR
authors: Ng
authors: Joan S
authors: JS
authors: Brugge
mesh_terms: D003094:Collagen / Q000378:metabolism*; D018450:Disease Progression; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000378:metabolism; D006801:Humans; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D010766:Phosphorylation; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism
chemical_list: D003094:Collagen; D008249:Protein-Lysine 6-Oxidase; D051416:Focal Adhesion Protein-Tyrosine Kinases