A personalized and optimal approach for dosing contrast material at coronary computed tomography angiography.
A method for constructing a personalized contrast medium protocol at contrast enhanced, Coronary CT Angiography (CCTA) is presented. A one compartment pharmacokinetic model is parameterized and identified with a minimal data set from a test-bolus injection. A direct-search optimization is performed to construct a protocol that achieves target enhancement in the cardiac structures. Clinical results demonstrating the method's ability to achieve prospectively chosen image enhancement levels while reducing contrast medium dose are presented.
Kalafut
John F
JF
MEDRAD Inc, Indianola, PA 15051, USA. jkalafut@medrad.com
Kemper
Corey A
CA
Suryani
Pal
P
Schoepf
U
U
D000465:Algorithms; D000792:Angiography / Q000379:methods*; D001011:Aorta / Q000473:pathology; D003287:Contrast Media / Q000494:pharmacology*; D017023:Coronary Angiography / Q000295:instrumentation* / Q000379:methods; D006321:Heart / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007455:Iodine / Q000493:pharmacokinetics; D015233:Models, Statistical; D010599:Pharmacokinetics; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*
D003287:Contrast Media; D007455:Iodine