Regulation of osteoclast apoptosis by Bcl-2 family protein Bim and Caspase-3.
Apopotosis of osteoclasts is regulated by the Bcl-2 family protein Bim. Bim is degraded in the course of osteoclast apoptosis, which is regulated by Caspase-3. Osteoclasts generated from caspase-3 -/- mice exhibited a shorter life span and a higher bone-resorbing activity than those generated from normal littermates. These results suggest the important role of Caspase-3-Bim axis in regulating both apoptosis and activation of osteoclasts.
Tanaka
Sakae
S
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan. tanakas-ort@h.u-tokyo.ac.jp
Wakeyama
Hidetoshi
H
Akiyama
Toru
T
Takahashi
Katsuhiko
K
Amano
Hitoshi
H
Nakayama
Keiichi I
KI
Nakamura
Kozo
K
D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D000072224:Bcl-2-Like Protein 11; D053148:Caspase 3 / Q000172:deficiency / Q000378:metabolism*; D002470:Cell Survival; D015536:Down-Regulation; D004622:Embryo, Mammalian / Q000166:cytology; D005347:Fibroblasts / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D010010:Osteoclasts / Q000166:cytology* / Q000201:enzymology*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*
D051017:Apoptosis Regulatory Proteins; D000072224:Bcl-2-Like Protein 11; C000606776:Bcl2l11 protein, mouse; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; D053148:Caspase 3