title: [Diagnostic value of transbronchial needle aspiration combined with transesophageal endoscopic ultrasound-guided fine needle aspiration in mediastinal and pulmonary hilar lesions].
abstract: OBJECTIVE
  To evaluate the value of transbronchial needle aspiration (TBNA) combined with transesophageal endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in the diagnosis of mediastinal and pulmonary hilar lesions as well as in the lymph node staging (N staging) of lung cancer.
  
  
  METHODS
  129 patients with mediastinal and pulmonary hilar lesions underwent either TBNA or EUS-FNA with cytological needle aspiration. The samples obtained from TBNA or EUS-FNA were examined by both cytologiy and histopathology.
  
  
  RESULTS
  Of the 129 patients, 59 underwent TBNA and 70 EUS-FNA. The diagnostic rate were 84.7% (50/59) by TBNA and 94.3% (66/70) by EUS-FNA, resepectively. The diagnosis of 116 (89.9%) patients were confirmed by either TBNA or EUS-FNA. The pathological and cytological diagnostic rates were 92.2% (107/116) and 88.0% (102/116), resepectively. The diagnostic rate was elevated by 8.4% (9/107) through pathological examination. The histological classification rates by cytological and pathological examination were 73.8% (76/116) and 89.3% (92/103), respectively. The diagnostic rate of histological classification was elevated by 35.5% (27/76) through pathological examination.
  
  
  CONCLUSIONS
  The combination of TBNA and EUS-FNA can improve the diagnostic rate for wider mediastinal and pulmlonary hilar lesions. Pathological examination of the samples obtained from the TBNA and EUS-FNA can elevate not only the rate of diagnosis but also the rate of histological classification.
authors: Department of Endoscopy, Cancer Hospital (Institute), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors: Xiao-Yan
authors: XY
authors: Li
authors: Gui-Yu
authors: GY
authors: Cheng
authors: Zhi-Hui
authors: ZH
authors: Zhang
authors: Ning
authors: N
authors: Lü
authors: Yue-Ming
authors: YM
authors: Zhang
authors: Shuang-Mei
authors: SM
authors: Zou
authors: Li-Yan
authors: LY
authors: Xue
authors: Lei
authors: L
authors: Zhang
authors: Xiao-Guang
authors: XG
authors: Ni
authors: Shao-Qing
authors: SQ
authors: Lai
authors: Shun
authors: S
authors: He
authors: Gui-Xiang
authors: GX
authors: Yu
authors: Feng-Huan
authors: FH
authors: Ju
authors: Hua-Ying
authors: HY
authors: Xun
authors: Rong-Rong
authors: RR
authors: Cheng
authors: Gui-Qi
authors: GQ
authors: Wang
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle / Q000379:methods*; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology; D019160:Endosonography / Q000379:methods; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary; D008482:Mediastinum; D008875:Middle Aged; D009367:Neoplasm Staging; D055752:Small Cell Lung Carcinoma / Q000000981:diagnostic imaging / Q000473:pathology*; D055815:Young Adult