title: Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages.
abstract: The adrenal cortex is a critical steroidogenic endocrine tissue, generated at least in part from the coelomic epithelium of the urogenital ridge. Neither the intercellular signals that regulate cortical development and maintenance nor the lineage relationships within the adrenal are well defined. We have explored adrenal Shh activity and found that Shh is expressed in relatively undifferentiated steroidogenic cells, which signal to the overlying capsule and subjacent nonsteroidogenic mesenchyme cells that we also find are progenitors of steroidogenic lineages. Shh-expressing cells also generate all steroidogenic cell types, but not nonsteroidogenic ones. Shh mutant adrenals have a thin capsule and small cortex. Our findings both support a novel dual lineage, Shh-independent and Shh-dependent, model of adrenocortical development, and identify distinct populations of adrenocortical progenitor and candidate stem cells.
authors: William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom.
authors: Peter
authors: P
authors: King
authors: Alex
authors: A
authors: Paul
authors: Ed
authors: E
authors: Laufer
mesh_terms: D000302:Adrenal Cortex / Q000737:chemistry / Q000254:growth & development*; D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D053823:Hedgehog Proteins / Q000032:analysis / Q000502:physiology*; D051741:Kruppel-Like Transcription Factors / Q000032:analysis; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology*; D013256:Steroids / Q000096:biosynthesis*; D000071676:Zinc Finger Protein GLI1
chemical_list: C498520:Gli1 protein, mouse; C498521:Gli1 protein, rat; D053823:Hedgehog Proteins; D051741:Kruppel-Like Transcription Factors; C465570:Shh protein, mouse; C546888:Shh protein, rat; D013256:Steroids; D000071676:Zinc Finger Protein GLI1