Hypoxia affected SDF-1alpha-CXCR4 interaction between bone marrow stem cells and osteoblasts via osteoclast modulation.
Cho
Kyung-Ah
KA
Department of Microbiology, School of Medicine, Ewha Womans University, 911-1 Mok-6-Dong, Seoul, Korea.
Ju
Sun-Young
SY
Ryu
Kyung-Ha
KH
Woo
So-Youn
SY
D016475:3T3 Cells; D000818:Animals; D001483:Base Sequence; D056657:Cathepsin K / Q000235:genetics; D002450:Cell Communication; D002454:Cell Differentiation / Q000187:drug effects; D015687:Cell Hypoxia / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D002460:Cell Line; D054377:Chemokine CXCL12 / Q000378:metabolism*; D003035:Cobalt / Q000633:toxicity; D017931:DNA Primers / Q000235:genetics; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics; D066298:In Vitro Techniques; D020780:Matrix Metalloproteinase 9 / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D010006:Osteoblasts / Q000378:metabolism*; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D019718:Receptors, CXCR4 / Q000378:metabolism*; D015854:Up-Regulation
C514936:CXCR4 protein, mouse; D054377:Chemokine CXCL12; D017931:DNA Primers; C497443:Hif1a protein, mouse; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D012333:RNA, Messenger; D019718:Receptors, CXCR4; D003035:Cobalt; D056657:Cathepsin K; C534132:Ctsk protein, mouse; D020780:Matrix Metalloproteinase 9; C501830:Mmp9 protein, mouse; C018021:cobaltous chloride