title: Delivery of a baby with severe combined immunodeficiency at 31 weeks gestation following an extreme preterm prelabour spontaneous rupture of the membranes: a case report.
abstract: BACKGROUND
  If left untreated, severe combined immunodeficiency can lead to an acute susceptibility to infection. The intrauterine environment is sterile until the amniotic membranes rupture. The vaginal flora then ascends into the genital tract, thus increasing the risk of chorioamnionitis. An extremely premature and prolonged membrane rupture is associated with a dismal prognosis for an immunocompetent preterm fetus. There are no case reports to date that detail the outcome of an immunocompromised preterm baby following prolonged rupture of membranes.
  
  
  METHODS
  We present the case of a 32-year-old Indian woman who delivered a 31-week gestational baby who had a severe combined immunodeficiency following premature prelabour prolonged rupture of the membranes at the 14(th )week of gestation.
  
  
  CONCLUSIONS
  Extreme preterm prelabour spontaneous rupture of membranes in an underlying condition of severe combined immunodeficiency does not necessarily lead to an unfavourable outcome.
authors: Department of Obstetrics and Gynaecology, Princess Royal University Hospital, Farnborough, Kent, UK.
authors: Sally J
authors: SJ
authors: Watkinson
authors: Christopher Ct
authors: CC
authors: Lee
authors: Christopher V
authors: CV
authors: Steer