title: Intravascular large B-cell lymphoma of the uterus: a case with favorable clinical outcome.
abstract: Intravascular lymphoma (IVL) of the uterus, a rare manifestation of malignant lymphoma, was diagnosed in a 71-year-old woman, who had fever, edema, and genital bleeding. Only 4 cases of uterine IVL have been reported in detail in the literature in English, to the author's knowledge. The patient was treated with total hysterectomy with bilateral salpingo-oophorectomy, accompanied by subsequent chemotherapy in combination with rituximab. Preoperative endometrial cytology and biopsy showed atypical lymphocytes intermingled with nonneoplastic epithelial cells. Intravascular proliferation of atypical lymphocytes was detected by histological examination of the resected materials, in which almost the entire uterine structure, including a large endometrial polyp, ovaries, and uterine tubes were involved. Immunohistochemically, tumor cells were positive for CD20 and CD79a and negative for CD5 and CD10. In situ hybridization for Epstein-Barr virus was negative. IVL generally has a poor prognosis. However, in the present case, the patient has been disease free for at least 51 months, and a favorable outcome can be expected.
authors: Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan. sheto@research.twmu.ac.jp
authors: Tomoko
authors: T
authors: Yamamoto
authors: Kazuo
authors: K
authors: Morita
authors: Noriyoshi
authors: N
authors: Iriyama
authors: Kiyotaka
authors: K
authors: Wakui
authors: Atsuko
authors: A
authors: Hiroi
authors: Tatsuo
authors: T
authors: Sawada
authors: Akihiro
authors: A
authors: Masuda
authors: Makio
authors: M
authors: Kobayashi
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D007044:Hysterectomy; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D010052:Ovariectomy; D058994:Salpingectomy; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*