Peroxisomes are oxidative organelles.
Peroxisomes are multifunctional organelles with an important role in the generation and decomposition of reactive oxygen species (ROS). In this review, the ROS-producing enzymes, as well as the antioxidative defense system in mammalian peroxisomes, are described. In addition, various conditions leading to disturbances in peroxisomal ROS metabolism, such as abnormal peroxisomal biogenesis, hypocatalasemia, and proliferation of peroxisomes are discussed. We also review the role of mammalian peroxisomes in some physiological and pathological processes involving ROS that lead to mitochondrial abnormalities, defects in cell proliferation, and alterations in the central nervous system, alcoholic cardiomyopathy, and aging. Antioxid.
Antonenkov
Vasily D
VD
Department of Biochemistry, University of Oulu, Oulu, Finland. vasily.antonenkov@oulu.fi
Grunau
Silke
S
Ohlmeier
Steffen
S
Hiltunen
J Kalervo
JK
D000375:Aging / Q000235:genetics / Q000378:metabolism; D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology; D020675:Peroxisomes / Q000235:genetics / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species