title: Prevalence of gastroduodenal mucosal injury in asymptomatic patients taking antiplatelet agents in Japan.
abstract: OBJECTIVE
  There is little knowledge regarding the prevalence of mucosal injury (MI) in Japanese patients receiving antiplatelet therapy. This study estimated the prevalence of gastroduodenal MI in asymptomatic Japanese patients taking antiplatelet agents and nonsteroidal anti-inflammatory drugs (NSAIDs).
  
  
  METHODS
  Among patients who underwent an upper gastrointestinal endoscopy at Teikyo University Hospital (Tokyo, Japan), 382 asymptomatic patients taking either low-dose aspirin, ticlopidine, cilostazol, or other NSAIDs and 119 people not taking any of these agents were included. Endoscopic records were evaluated for the presence of MI.
  
  
  RESULTS
  Aspirin and NSAIDs users showed a higher prevalence of MI than controls (Aspirin, OR = 2.6 (95% CI = 1.4 - 4.9), NSAIDs, 2.9 (1.4 - 4.4)). Concomitant use of aspirin and NSAIDs increased the prevalence of MI (11.2 (2.8 - 44.8)). Ticlopidine and cilostazol were less likely to cause injury than aspirin and other NSAIDs, the difference remained insignificant due to small sample number (ticlopidine, 0.8 (0.2 - 4.0), cilostazol, 1.3 (0.3 - 4.8)).
  
  
  CONCLUSIONS
  In asymptomatic Japanese patients receiving low-dose aspirin, the prevalence of the gastroduodenal MI was the same as that in patients taking NSAIDs and higher than that in controls.
authors: Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan. ymmt@med.teikyo-u.ac.jp
authors: T
authors: T
authors: Yamamoto
authors: A
authors: A
authors: Isono
authors: T
authors: T
authors: Ebato
authors: Y
authors: Y
authors: Mishina
authors: Y
authors: Y
authors: Shirasaki
authors: K
authors: K
authors: Abe
authors: K
authors: K
authors: Hattori
authors: T
authors: T
authors: Ishii
authors: Y
authors: Y
authors: Kuyama
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004382:Duodenitis / Q000139:chemically induced / Q000453:epidemiology*; D005260:Female; D005756:Gastritis / Q000139:chemically induced / Q000453:epidemiology*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000453:epidemiology*; D016481:Helicobacter Infections / Q000097:blood / Q000453:epidemiology; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D015995:Prevalence
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010975:Platelet Aggregation Inhibitors