title: Comparing the effects of acupuncture and electroacupuncture at Zusanli and Baihui on cell proliferation and neuroblast differentiation in the rat hippocampus.
abstract: We compared the effects of acupuncture and electroacupuncture on cell proliferation and neuroblast differentiation using specific markers, Ki67 and doublecortin (DCX), in the subgranular zone of the dentate gyrus (SZDG) in 13-week old Wistar rats. Acupuncture and electroacupuncture were applied simultaneously in the acu-points, ST36 (Zusanli) and GV20 (Baihui), once a day for 3 weeks. Acupuncture and electroacupuncture at these acu-points significantly increased the number of Ki67-positive cells and DCX-immunoreactive neuroblasts compared to the control or sham acupuncture group. Electroacupuncture treatment significantly increased the number of well-developed (tertiary) dendrites in the SZDG compared to acupuncture treatment. These results suggest that both acupuncture and electroacupuncture increase neurogenesis in the normal, but that electroacupuncture has greater effects on neuroblast plasticity than acupuncture in the dentate gyrus.
authors: Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, South Korea.
authors: In Koo
authors: IK
authors: Hwang
authors: Jin Young
authors: JY
authors: Chung
authors: Dae Young
authors: DY
authors: Yoo
authors: Sun Shin
authors: SS
authors: Yi
authors: Hwa Young
authors: HY
authors: Youn
authors: Je Kyung
authors: JK
authors: Seong
authors: Yeo Sung
authors: YS
authors: Yoon
mesh_terms: D026881:Acupuncture / Q000379:methods*; D015669:Acupuncture Points; D015670:Acupuncture Therapy; D000818:Animals; D002545:Brain Ischemia / Q000628:therapy; D002454:Cell Differentiation; D002455:Cell Division / Q000502:physiology*; D018891:Dentate Gyrus / Q000166:cytology; D000089662:Doublecortin Protein; D015671:Electroacupuncture / Q000379:methods*; D004827:Epilepsy / Q000628:therapy; D006624:Hippocampus / Q000166:cytology*; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: C000714848:Dcx protein, rat; D000089662:Doublecortin Protein; D019394:Ki-67 Antigen