Early induction of hypothermia during cardiac arrest improves neurological outcomes in patients with out-of-hospital cardiac arrest who undergo emergency cardiopulmonary bypass and percutaneous coronary intervention.
BACKGROUND
Therapeutic hypothermia for comatose survivors of out-of-hospital cardiac arrest has demonstrated neurological benefits. Although early cooling during cardiac arrest enhances efficacy in animal studies, few clinical studies are available.


RESULTS
The 171 patients who failed to respond to conventional cardiopulmonary resuscitation were studied prospectively. Patients underwent emergency cardiopulmonary bypass (CPB) plus intra-aortic balloon pumping, with subsequent percutaneous coronary intervention (PCI) if needed. Mild hypothermia (34 degrees C for 3 days) was induced during cardiac arrest or after return of spontaneous circulation. Of the 171 patients, 21 (12.3%) had a favorable neurological outcome at hospital discharge. An unadjusted rate of favorable outcome decreased in a stepwise fashion for increasing quartiles of collapse-to-34 degrees C interval (P=0.016). An adjusted odds ratio for favorable outcome after collapse-to-CPB interval was 0.89 (95% confidence interval (CI) 0.82-0.97) and after CPB-to-34 degrees C interval, 0.99 (95%CI 0.98-0.99) when collapse-to-34 degrees C interval was divided into 2 components. Favorable neurological accuracy of a collapse-to-CPB interval at a cutoff of 55.5 min and CPB-to-34 degrees C interval at a cutoff of 21.5 min was 85.4% and 89.5%, respectively.


CONCLUSIONS
Early attainment of a core temperature had neurological benefits for patients with out-of-hospital cardiac arrest who underwent CPB and PCI. (Circ J 2010; 74: 77 - 85).
Nagao
Ken
K
Department of Cardiology, Resuscitation and Emergency Cardiovascular Care, Surugadai Nihon University Hospital, Japan. kennagao@med.nihon-u.ac.jp
Kikushima
Kimio
K
Watanabe
Kazuhiro
K
Tachibana
Eizo
E
Tominaga
Yoshiteru
Y
Tada
Katsushige
K
Ishii
Mitsuru
M
Chiba
Nobutaka
N
Kasai
Asuka
A
Soga
Taketomo
T
Matsuzaki
Masakazu
M
Nishikawa
Kei
K
Tateda
Yutaka
Y
Ikeda
Harumi
H
Yagi
Tsukasa
T
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D001831:Body Temperature / Q000502:physiology; D002315:Cardiopulmonary Bypass; D016887:Cardiopulmonary Resuscitation; D005112:Extracorporeal Circulation; D005260:Female; D006323:Heart Arrest / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology / Q000517:prevention & control*; D016017:Odds Ratio; D010045:Outpatients; D011446:Prospective Studies; D012372:ROC Curve; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome