title: [Lanzoptol efficiency for heartburn alleviation in patients with NERD].
abstract: Now you can find a growing interest in modern proton pump inhibitors. This article presents results of Lanzoptol (lansoprazol company "Krka", Slovenia) drug study. This study involved 30 people including 13 women and 17 men. Study included patients with NERD aged from 18 to 65 years with clinical manifestations like pyrosis, regurgitation, epigastrium pain and in with absence of esophageal ulcers and erosions at endoscopic study. Duration of disease ranged from 2 months to 20 years. Results of the therapy: completely stopped heartburn for 4 weeks of treatment at 26 people (87%), partly--at 4. 9 patients got acute pharmacological test with 48-hour pH meter. The average time percentage at pH <4 decreased in 2 times, amount of acid esophageal reflux at pH <4--decreased in 4,5 times, the number of long-Esophageal Reflux decreased in 1,5 times. De Meester combined ratio decreased in 2 times. According to the daily pH meter speed of antisecretory effect on the average was 135 minutes. Lanzopotol portability is good, side effects hasn't been identified. So, Lanzoptol demonstrated a high rate of antisecretory effect and high clinical efficacy with an excellent portability.
authors: M F
authors: MF
authors: Osipenko
authors: E A
authors: EA
authors: Bikbulatova
authors: Iu D
authors: IuD
authors: Shakalite
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy*; D006356:Heartburn / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D064747:Lansoprazole; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D054328:Proton Pump Inhibitors; D064747:Lansoprazole