[Preventive effects of pueraria on presbycusis in rats].
OBJECTIVE
To investigate the preventive effects of Pueraria on presbycusis in rats.


METHODS
Thirty-two 24-26 month old Wistar rats were randomly divided into four groups, and were treated with different dosages of Pueraria (1, 2, 4, 0 g x kg(-1) x d(-1)) separately for 4 weeks. Auditory brainstem response (ABR) was used to detect the change of hearing threshold of rats. Hemorheological items of rats were checked in each group.


RESULTS
Compared with control group, the hearing threshold and hemorheological items of rats was significantly improved after treated with Pueraria (P<0.05). In addition, 2 g/(kg x d) was found to be the best dosage of Pueraria for rats, which can achieve ideal effect with minimum side effect.


CONCLUSIONS
Pueraria could improve tiny circulation, has good preventive effect on presbycusis of rats.
Chen
Wangyan
W
Department of Otorhinolaryngology, Chinese and Western Medicine Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China. meniere@163.com
Yao
Qi
Q
Liu
Weihong
W
Zhang
Bibo
B
Wang
Ying
Y
Liu
Bo
B
D000375:Aging; D000818:Animals; D001309:Auditory Threshold; D016057:Evoked Potentials, Auditory, Brain Stem; D018056:Hemorheology; D008517:Phytotherapy; D011304:Presbycusis / Q000188:drug therapy*; D029908:Pueraria / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar