title: [Association of genetic polymorphism in phenylethanolamine-N-methyl transferase with essential hypertension in Changsha Han people].
abstract: OBJECTIVE
  To investigate the association of phenylethanolamine-N-methyl transferase (PNMT) G-390A genetic polymorphism with risk of essential hypertension (EH) in Changsha Han people.
  
  
  METHODS
  A case-control association study was performed in 400 patients with essential hypertension (EH) and 388 normotensive subjects. PNMT G-390A was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-FRLP).
  
  
  RESULTS
  The genotype frequencies for the -390 GG, GA, and AA were 39.3%,50.0%, and 10.8%, respectively in EH patients, and were 43.6%,45.6%, and 10.8%, in normal subjects. No significant difference in either genotypic frequency (P=0.433) or allele frequency (P=0.378) of PNMT G-390A between EH patients and normals was observed. When by gender, there was significant difference in genotypic frequency (P<0.05) and allele frequency (P=0.046) of G-390A polymorphism between EH patients and normals in the male, but not in the female (P>0.05).
  
  
  CONCLUSIONS
  PNMT G-390A polymorphism is possibly associated with EH risk in male Chinese Han population in Changsha.
authors: Department of Cardiovasology, Central South University, Changsha 410008, China.
authors: An
authors: A
authors: Chen
authors: Xiaoping
authors: X
authors: Chen
authors: Ruizheng
authors: R
authors: Shi
authors: Yijie
authors: Y
authors: Guo
authors: Lujia
authors: L
authors: Chen
authors: Mingxuan
authors: M
authors: Xie
authors: Tianlun
authors: T
authors: Yang
authors: Guogang
authors: G
authors: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001483:Base Sequence; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010625:Phenylethanolamine N-Methyltransferase / Q000235:genetics*; D011110:Polymorphism, Genetic; D012737:Sex Factors
chemical_list: D010625:Phenylethanolamine N-Methyltransferase