title: Novel, tunable, and efficient chiral bisdihydrobenzooxaphosphole ligands for asymmetric hydrogenation.
abstract: A series of novel, efficient, air-stable, and tunable chiral bisdihydrobenzooxaphosphole ligands (BIBOPs) were developed for rhodium-catalyzed hydrogenations of various functionalized olefins such as alpha-arylenamides, alpha-(acylamino)acrylic acid derivatives, beta-(acylamino)acrylates, and dimethyl itaconate with excellent enantioselectivities (up to 99% ee) and reactivities (up to 2000 TON).
authors: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut 06877, USA. wenjun.tang@boerhinger-ingelheim.com
authors: Wenjun
authors: W
authors: Tang
authors: Bo
authors: B
authors: Qu
authors: Andrew G
authors: AG
authors: Capacci
authors: Sonia
authors: S
authors: Rodriguez
authors: Xudong
authors: X
authors: Wei
authors: Nizar
authors: N
authors: Haddad
authors: Bikashandarkoil
authors: B
authors: Narayanan
authors: Shengli
authors: S
authors: Ma
authors: Nelu
authors: N
authors: Grinberg
authors: Nathan K
authors: NK
authors: Yee
authors: Dhileep
authors: D
authors: Krishnamurthy
authors: Chris H
authors: CH
authors: Senanayake
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006865:Hydrogenation; D008024:Ligands; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000179:Acrylates; D000475:Alkenes; D008024:Ligands; D009943:Organophosphorus Compounds; D012238:Rhodium