The uleine-rich fraction of Himatanthus lancifolius blocks proliferative responses of human lymphoid cells.
The purpose of the present work is to report the effects shown by the uleine-rich fraction extracted from the barks of Himatanthus lancifolius (Muell. Arg.) Woodson (Apocynaceae) on human peripheral blood mononuclear cells in which we were able to inhibit the proliferation of phytohemagglutinin-stimulated lymphocytes by blocking their transformation into blast-dividing cells. Furthermore, it inhibited the proliferation of Daudi and Reh cells, two leukemic cell lines of lymphoid origin. The present study widens the biological applications of H. lancifolius' alkaloids to include its possible use as a modulator of the immune system.
Nardin
Jeanine Marie
JM
Laboratory of Hematology, Department of Medical Pathology, Federal University of Paraná, 80210-070 Curitiba, Brazil.
Lima
Melissa Pires
MP
Machado
Julio Cesar
JC
Hilst
Luciana Farhat
LF
Santos
Cid Aimbiré de Moraes
CA
Weffort-Santos
Almeriane Maria
AM
D000470:Alkaloids / Q000032:analysis / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000032:analysis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects*; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*
D000470:Alkaloids; D001952:Bridged-Ring Compounds; D010936:Plant Extracts; C428545:uleine