Interval timing disruptions in subjects with cerebellar lesions.
The cerebellum has long been implicated in time perception, particularly in the subsecond range. The current set of studies examines the role of the cerebellum in suprasecond timing, using analysis of behavioral data in subjects with cerebellar lesions. Eleven cerebellar lesion subjects and 17 controls were tested on temporal estimation, reproduction and production, for times ranging from 2 to 12s. Cerebellar patients overproduced times on both the reproduction and production tasks; the effect was greatest at the shortest duration. A subset of patients also underestimated intervals. Cerebellar patients were significantly more variable on the estimation and reproduction tasks. No significant differences between normal and cerebellar patients were found on temporal discrimination tasks with either sub- or suprasecond times. Patients with damage to the lateral superior hemispheres or the dentate nuclei showed more significant impairments than those with damage elsewhere in the cerebellum, and patients with damage to the left cerebellum had more significant differences from controls than those with damage to the right. These data suggest that damage to the middle-to-superior lobules or the left hemisphere is especially detrimental to timing suprasecond intervals. We suggest that this region be considered part of a network of brain structures including the DLPFC that is crucial for interval timing.
Gooch
Cynthia M
CM
Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce St., 2 Gibson/4283, Philadelphia, PA 19104, USA. cgooch@mail.med.upenn.edu
Wiener
Martin
M
Wencil
Elaine B
EB
Coslett
H Branch
HB
D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000150:complications; D016022:Case-Control Studies; D002529:Cerebellar Nuclei / Q000473:pathology / Q000503:physiopathology; D002531:Cerebellum / Q000473:pathology* / Q000503:physiopathology*; D004192:Discrimination, Psychological; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D013998:Time Perception