title: Antimicrobial susceptibility of multidrug-resistant Streptococcus pneumoniae strains with penicillin MICs of 8 to 32 mg/L.
abstract: The in vitro activity of 22 antibiotics (including novobiocin) and beta-lactam/gentamicin combinations was assessed against 11 multidrug-resistant pneumococcal strains. Among orally administered drugs, only telithromycin, levofloxacin, and linezolid were active against all isolates, but their use is not indicated in pediatrics. Novobiocin could be a potential therapeutic alternative.
authors: Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundación Jiménez Díaz-Capio, 28040 Madrid, Spain. vrodriguez@cib.csic.es
authors: Violeta
authors: V
authors: Rodríguez-Cerrato
authors: Matilde
authors: M
authors: Gracia
authors: Gema
authors: G
authors: Del Prado
authors: Lorena
authors: L
authors: Huelves
authors: Plínio
authors: P
authors: Naves
authors: Vicente
authors: V
authors: Ruiz
authors: Carmen
authors: C
authors: Ponte
authors: Francisco
authors: F
authors: Soriano
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D011008:Pneumococcal Infections / Q000382:microbiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins