title: Chelation-assisted palladium-catalyzed cascade bromination/cyanation reaction of 2-arylpyridine and 1-arylpyrazole C-H bonds.
abstract: A chelation-assisted palladium-catalyzed cascade bromination/cyanation reaction of 2-arylpyridine and 1-arylpyrazole C-H bonds has been developed. Notably, the reaction employs K(3)[Fe(CN)(6)] as a safe and nontoxic cyanide source, providing aromatic nitriles in moderate to good yields in one-pot. The procedure tolerates methoxy, chloro, fluoro, cyano, trifluoromethyl, and carbomethoxy groups.
authors: College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325027, PR China.
authors: Xiaofei
authors: X
authors: Jia
authors: Dongpeng
authors: D
authors: Yang
authors: Wenhui
authors: W
authors: Wang
authors: Fang
authors: F
authors: Luo
authors: Jiang
authors: J
authors: Cheng
mesh_terms: D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D002614:Chelating Agents / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D005292:Ferricyanides / Q000737:chemistry; D054879:Halogenation; D006859:Hydrogen / Q000737:chemistry*; D008956:Models, Chemical; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001555:Benzene Derivatives; D002614:Chelating Agents; D003486:Cyanides; D005292:Ferricyanides; D009570:Nitriles; D011720:Pyrazoles; D011725:Pyridines; D010165:Palladium; D002244:Carbon; D006859:Hydrogen; C028033:potassium ferricyanide