The Effect of Caffeic Acid on Wound Healing in Skin-incised Mice.
This study was carried out to investigate the wound healing effect of caffeic acid in skin-incised mice. Caffeic acid showed significant effects on anti-inflammatory activity and wound healing, such as myeloperoxidase activity, lipid peroxidation, phospholipase A(2) activity and collagen-like polymer synthesis, in incised-wound tissue. On the other hand, it significantly stimulated collagen-like polymer synthesis in NIH 3T3 fibroblast cells, while inhibited both silica-induced reactive oxygen species generation and melittin-induced arachidonic acid release and PGE(2) production in Raw 264.7 cells, and histamine release in RBL 2H3 cells stimulated by melittin or arachidonic acid. Therefore, caffeic acid appears to have a potent antioxidant and anti-inflammatory effect in cell culture system, which may be related to wound healing in skin-incised mice.
Song
Ho Sun
HS
Department of Pathophysiology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
Park
Tae Wook
TW
Sohn
Uy Dong
UD
Shin
Yong Kyoo
YK
Choi
Byung Chul
BC
Kim
Chang Jong
CJ
Sim
Sang Soo
SS