Symptomatic hypocalcemia in primary hyperaldosteronism: a case report.
The metabolic alterations caused by hyperaldosteronism are being increasingly recognized and have generated considerable interest among the medical fraternity. Hyperaldosteronism is suspected to have a pivotal role in the patho-physiology of congestive cardiac failure where it has been studied extensively. But its effects on calcium metabolism, parathyroid metabolism and renal handling of calcium are less well described. Recent experimental models have shed light into the roles played by previously unknown mechanisms in causing these metabolic alterations. We hereby report a case of primary hyperaldosteronism due to adrenal adenoma (Conn's syndrome) who presented with a myriad of clinical features including symptomatic hypocalcemia, significant weight loss along with uncontrolled hypertension for a prolonged period before eventually detected to have primary hyperaldosteronism. Surgical removal of the causative tumor resulted in prompt disappearance of all the symptoms and signs and regain of lost weight.
Pai
Sachin G
SG
Department of Medicine, Kasturba Medical College, Manipal, Karnataka, India. sachingpai@gmail.com
Shivashankara
K N
KN
Pandit
V
V
Sheshadri
S
S
D000306:Adrenal Cortex Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D018246:Adrenocortical Adenoma / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D000328:Adult; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000209:etiology / Q000503:physiopathology; D006996:Hypocalcemia / Q000209:etiology*; D011247:Pregnancy; D016896:Treatment Outcome