title: Synthesis and biological evaluation of N-aryl-1,4-dihydropyridines as novel antidyslipidemic and antioxidant agents.
abstract: N-aryl-1,4-dihydropyridines 2a-n were synthesized via iodine catalyzed three-component reaction of cinnamaldehydes, anilines and 2-keto esters in methanol. The synthesized compounds were screened for their antidyslipidemic and antioxidant activity in vivo and in vitro. Compounds 2a, 2g, and 2l have exhibited promising lipid and TG lowering activity, whereas compounds 2m and 2n have showed potent antioxidant activity.
authors: Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, UP 226001, India. dratulsax@gmail.com
authors: Atul
authors: A
authors: Kumar
authors: Ram Awatar
authors: RA
authors: Maurya
authors: Siddharth
authors: S
authors: Sharma
authors: Mukesh
authors: M
authors: Kumar
authors: Gitika
authors: G
authors: Bhatia
mesh_terms: D000818:Animals; D002384:Catalysis; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007455:Iodine / Q000737:chemistry; D008055:Lipids / Q000097:blood; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D051381:Rats
chemical_list: D004095:Dihydropyridines; D016166:Free Radical Scavengers; D000960:Hypolipidemic Agents; D008055:Lipids; C038806:1,4-dihydropyridine; D007455:Iodine