Low grade cerebellar T-cell lymphoma: a novel response to treatment; a case report.
Low-grade primary T-cell lymphoma of the central nervous system is extremely rare. We present a case developing in a previously fit young woman presenting with symptoms of raised intracranial pressure and found on CT to have a cerebellar mass. Biopsy of this lesion revealed features of non-Hodgkin's lymphoma with histochemical analysis confirming T-cell phenotype and a Ki67 proliferation index of only 1%. Contrary to the prevailing view in the literature, the patient's clinical condition deteriorated following high-dose intravenous methotrexate and improved after a short course of whole-brain radiotherapy.
Corns
Robert
R
Departments of Neurosurgery, King's College Hospital, Denmark Hill, London SE5 9RS, UK. cilfodan@hotmail.com
Crocker
Matthew
M
Kumar
Atul
A
Salisbury
Jon
J
Tolias
Christos
C
Sadler
Gill
G
Hill
Mark
M
D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D002531:Cerebellum / Q000473:pathology; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D003907:Dexamethasone / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D019394:Ki-67 Antigen / Q000032:analysis; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use*; D009460:Neurologic Examination; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed
D000964:Antimetabolites, Antineoplastic; D018931:Antineoplastic Agents, Hormonal; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D003907:Dexamethasone; D008727:Methotrexate