title: Time-of-flight secondary ion mass spectrometry study on the distribution of alendronate sodium in drug-loaded ultra-high molecular weight polyethylene.
abstract: The aim of this study was to investigate the drug distribution in ultra-high molecular weight polyethylene (UHMWPE) loaded with alendronate sodium (ALN), which was developed to treat particle-induced osteolysis after artificial joint replacements, since the drug distribution in UHMWPE could play a key role in controlling drug release. A mixture of UHMWPE powder and ALN was dried and hot pressed to prepare UHMWPE loaded with ALN (UHMWPE-ALN). Fourier transform infrared spectroscopy analysis demonstrated that the hot press had no effect on the functional groups of ALN in UHMWPE-ALN. X-ray diffraction indicated that there was no phase change of the UHMWPE after hot pressing. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) spectra revealed the existence of characteristic elements and functional groups from ALN in UHMWPE-ALN, such as Na+, C3H8N+, PO3(-) and PO3H(-). In addition, SIMS images suggested that ALN did not agglomerate in UHMWPE-ALN. A small punch test and hardness test were carried out and the results indicated that ALN did not affect the mechanical properties at the present content level. The present study demonstrated that it was feasible to fabricate the un-agglomerated distributed drug in UHMWPE with good mechanical properties. This ALN loaded UHMWPE would have potential application in clinics.
authors: Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China.
authors: Xiaomin
authors: X
authors: Liu
authors: Shuxin
authors: S
authors: Qu
authors: Xiong
authors: X
authors: Lu
authors: Xiang
authors: X
authors: Ge
authors: Yang
authors: Y
authors: Leng
mesh_terms: D019386:Alendronate / Q000737:chemistry*; D019643:Arthroplasty, Replacement / Q000295:instrumentation* / Q000379:methods; D001672:Biocompatible Materials / Q000737:chemistry*; D016503:Drug Delivery Systems; D006245:Hardness Tests; D006801:Humans; D007477:Ions; D013058:Mass Spectrometry / Q000379:methods*; D008422:Materials Testing; D010014:Osteolysis / Q000378:metabolism; D011095:Polyethylenes / Q000737:chemistry*; D011208:Powders; D017550:Spectroscopy, Fourier Transform Infrared; D013314:Stress, Mechanical; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D007477:Ions; D011095:Polyethylenes; D011208:Powders; C111601:ultra-high molecular weight polyethylene; D019386:Alendronate