title: CRP polymorphisms and progression of chronic kidney disease in African Americans.
abstract: OBJECTIVE
  Chronic inflammation may play a role in chronic kidney disease (CKD) progression. CRP gene polymorphisms are associated with serum C-reactive protein (CRP) concentrations. It is unknown if CRP polymorphisms are associated with CKD progression or modify the effectiveness of anti-hypertensive therapy in delaying CKD progression.
  
  
  METHODS
  We genotyped 642 participants with CKD from the African American Study of Kidney Disease and Hypertension (AASK), selecting five tag polymorphisms: rs2808630, rs1205, rs3093066, rs1417938, and rs3093058. We compared the minor allele frequencies (MAF) of single nucleotide polymorphisms (SNPs) in AASK to MAFs of African Americans from NHANES III. Among AASK participants, we evaluated the association of SNPs with CRP levels and prospectively with a composite: halving the GFR, ESRD, or death.
  
  
  RESULTS
  The MAF was higher for the rs2808630_G allele (P = 0.03) and lower for the rs1205_A allele (P = 0.03) in the AASK compared with NHANES III. Among AASK participants, the rs3093058_T allele predicted higher CRP concentrations (P < 0.0001) but not CKD progression. The rs2808630_GG genotype was associated with higher risk of the composite endpoint compared with the AA genotype (P = 0.002). Participants with the rs2808630_GG genotype on angiotensin converting enzyme inhibitors (ACEIs) versus beta blockers had increased risk of progression (P = 0.03).
  
  
  CONCLUSIONS
  CRP SNPs that were associated with higher levels of CRP did not predict CKD progression. The rs2808630_GG genotype was associated with higher risk of CKD progression, and in patients with this genotype, ACEIs did not slow progression.
authors: Vanderbilt University Medical Center, 1161 21st Avenue South & Garland, Division of Nephrology, S-3223 MCN, Nashville, TN 37232-2372, USA. Adriana.hung@vanderbilt.edu
authors: Adriana M
authors: AM
authors: Hung
authors: Dana C
authors: DC
authors: Crawford
authors: Marie R
authors: MR
authors: Griffin
authors: Kristin
authors: K
authors: Brown-Gentry
authors: Michael S
authors: MS
authors: Lipkowitz
authors: Edward D
authors: ED
authors: Siew
authors: Kerri
authors: K
authors: Cavanaugh
authors: Julia B
authors: JB
authors: Lewis
authors: T Alp
authors: TA
authors: Ikizler
mesh_terms: D001741:Black or African American; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002097:C-Reactive Protein / Q000235:genetics*; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011446:Prospective Studies
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002097:C-Reactive Protein