Protein kinase Czeta: not-so-innocent bystander or unusual suspect in kidney transplant rejection?
Antibodies against non-HLA targets are increasingly recognized in the context of transplant rejection. However, their specific role remains largely elusive, as evidence exists supporting both their occurrence as an epiphenomenon and their actual pathogenicity in the rejection process. Sutherland et al. describe protein kinase Czeta as a novel, non-HLA antigenic target in the setting of graft rejection.
Goebel
Jens W D
JW
Nephrology and Hypertension Section, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. jens.goebel@cchmc.org
D000941:Antigens; D006084:Graft Rejection / Q000201:enzymology / Q000209:etiology* / Q000276:immunology; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D021962:Membrane Microdomains / Q000201:enzymology / Q000276:immunology; D018448:Models, Immunological; D011493:Protein Kinase C / Q000276:immunology*; D000099221:Protein Kinase C zeta
D000941:Antigens; D011493:Protein Kinase C; D000099221:Protein Kinase C zeta