title: Two novel neo-clerodane diterpenoids from Scutellaria barbata.
abstract: Two novel neo-clerodane diterpenoids, barbatellarines A (1) and B (2), were isolated from the whole plants of Scutellaria barbata, along with the known compound scutebarbatine F (3). The chemical structures and relative stereochemistry of the isolated compounds were established by NMR (1D and 2D) and mass spectroscopic analyses. Compounds 2 and 3 were evaluated for in vitro cytotoxic activity against the HL-60 (human leukemia), MCF7 (human breast cancer), and LLC (Lewis lung carcinoma) cancer cell lines. Compound 2 exhibited weak cytotoxic activity against HL-60 cells, with an IC(50) value of 41.4microM.
authors: School of Biotechnology, Yeungnam University, 214-1 Dae-dong, Gyeongsan, Gyeongbuk 712-749, South Korea.
authors: Hanna
authors: H
authors: Lee
authors: Yujin
authors: Y
authors: Kim
authors: Inho
authors: I
authors: Choi
authors: Byung Sun
authors: BS
authors: Min
authors: Sang Hee
authors: SH
authors: Shim
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D031363:Scutellaria / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045785:Diterpenes, Clerodane; C549134:barbatellarine A; C549135:barbatellarine B