title: Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity.
abstract: Mechanisms by which whole chromosome instability lead to tumorigenesis have eluded the cancer research field. In this issue of Cancer Cell, Baker et al. show that CIN induced by a defective mitotic checkpoint, under certain genetic and tissue contexts, leads to accelerated loss of heterozygosity of a tumor suppressor gene.
authors: Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors: Rocio
authors: R
authors: Sotillo
authors: Juan-Manuel
authors: JM
authors: Schvartzman
authors: Robert
authors: R
authors: Benezra
mesh_terms: D043171:Chromosomal Instability; D016147:Genes, Tumor Suppressor; D006801:Humans; D019656:Loss of Heterozygosity