A facile construction strategy of stable lipid nanoparticles for drug delivery using a hydrogel-thickened microemulsion system.
We report a novel facile method for preparing stable nanoparticles with inner spherical solid spheres and an outer hydrogel matrix using a hot O/W hydrogel-thickened microemulsion with spontaneous stability. The nanoparticles with average diameters of about 30.0 nm and 100.0 nm were constructed by cooling the hot hydrogel-thickened microemulsion at different temperatures, respectively. We explained the application of these nanoparticles by actualizing the cutaneous delivery of drug-loaded nanoparticles. The in vitro skin permeation studies showed that the nanoparticles could significantly reduce the penetration of model drugs through skin and resulted in their dermal uptakes in skin. The sol-gel process of TEOS was furthermore used in the template of HTM to regulate the particle size of nanoparticles. The coating of silica on the surface of nanoparticles could regulate the penetration of drug into skin from dermal delivery to transdermal delivery. This strategy provides a facile method to produce nanoparticles with long-term stability and ease of manufacture, which might have a promising application in drug delivery.
Chen
Huabing
H
College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, People's Republic of China.
Xiao
Ling
L
Du
Danrong
D
Mou
Dongsheng
D
Xu
Huibi
H
Yang
Xiangliang
X
D000818:Animals; D004224:Diterpenes / Q000008:administration & dosage / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D004655:Emulsions; D004852:Epoxy Compounds / Q000008:administration & dosage / Q000378:metabolism; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D066298:In Vitro Techniques; D008055:Lipids / Q000008:administration & dosage / Q000737:chemistry*; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D010616:Phenanthrenes / Q000008:administration & dosage / Q000378:metabolism; D011034:Podophyllotoxin / Q000008:administration & dosage / Q000378:metabolism; D051381:Rats; D012822:Silicon Dioxide / Q000737:chemistry; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D014961:X-Ray Diffraction
D004224:Diterpenes; D004655:Emulsions; D004852:Epoxy Compounds; D008055:Lipids; D010616:Phenanthrenes; C001899:triptolide; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D012822:Silicon Dioxide; D011034:Podophyllotoxin