title: Synthesis of 2-hydroxymethyl ketones by ruthenium hydride-catalyzed cross-coupling reaction of alpha,beta-unsaturated aldehydes with primary alcohols.
abstract: The cross-coupling reaction of alpha,beta-unsaturated aldehydes with primary alcohols to give 2-hydroxymethyl ketones was achieved using RuHCl(CO)(PPh(3))(3) as a catalyst. This atom-economical reaction is likely to proceed via the hydroruthenation of alpha,beta-unsaturated aldehydes followed by an aldol reaction of the resultant enolates with aldehydes to give alpha-formylated ketones, which undergo transfer hydrogenation with primary alcohols leading to alpha-hydroxymethyl ketones. The reduction step can generate aldehydes, participating in the next catalytic cycle.
authors: Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.
authors: Aurélien
authors: A
authors: Denichoux
authors: Takahide
authors: T
authors: Fukuyama
authors: Takashi
authors: T
authors: Doi
authors: Jiro
authors: J
authors: Horiguchi
authors: Ilhyong
authors: I
authors: Ryu