[The assessment of remote cytogenetic effects in clean up workers of Chernobyl accident].
Cytogenetic study cohort of the liquidators of the consequences of Chernobyl accident over 4-6 years after clean-up working in the alienation zone was carried out by conventional method. For The results of study liquidators cohort of 1986-1987 years have shown decreasing the frequency of cells with unstable chromosome aberrations for 25-30% per each year of examination. The frequency of chromosomal and chromatid-type aberrations have been also decreasing. The increasing of frequency radiation markers (dicentrics and rings) was observed for liquidators who worked in Chernobyl in 1988 year. Significant distinctions on other cytogenetics parameters as well as for liquidators who worked in Chernobyl in 1989 year were not observed perhaps of small number of examined cohorts. Nevertheless level of chromosome aberrations observed in remote post radiation period was significantly higher then controls that may be caused by radiation-induced genome instability. Obtained data show the importance of cytogenetic examination of that cohort for estimation and the prognosis the risk of delayed negative consequences of exposure.
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D000328:Adult; D000368:Aged; D002478:Cells, Cultured; D047852:Chernobyl Nuclear Accident; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000473:pathology / Q000528:radiation effects; D008875:Middle Aged; D009784:Occupational Diseases / Q000235:genetics*; D016273:Occupational Exposure / Q000009:adverse effects*; D011832:Radiation Injuries / Q000209:etiology / Q000235:genetics*; D013997:Time Factors