title: Regulation of osteoclast apoptosis by Bcl-2 family protein Bim and Caspase-3.
abstract: Apopotosis of osteoclasts is regulated by the Bcl-2 family protein Bim. Bim is degraded in the course of osteoclast apoptosis, which is regulated by Caspase-3. Osteoclasts generated from caspase-3 -/- mice exhibited a shorter life span and a higher bone-resorbing activity than those generated from normal littermates. These results suggest the important role of Caspase-3-Bim axis in regulating both apoptosis and activation of osteoclasts.
authors: Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan. tanakas-ort@h.u-tokyo.ac.jp
authors: Sakae
authors: S
authors: Tanaka
authors: Hidetoshi
authors: H
authors: Wakeyama
authors: Toru
authors: T
authors: Akiyama
authors: Katsuhiko
authors: K
authors: Takahashi
authors: Hitoshi
authors: H
authors: Amano
authors: Keiichi I
authors: KI
authors: Nakayama
authors: Kozo
authors: K
authors: Nakamura
mesh_terms: D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D000072224:Bcl-2-Like Protein 11; D053148:Caspase 3 / Q000172:deficiency / Q000378:metabolism*; D002470:Cell Survival; D015536:Down-Regulation; D004622:Embryo, Mammalian / Q000166:cytology; D005347:Fibroblasts / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D010010:Osteoclasts / Q000166:cytology* / Q000201:enzymology*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*
chemical_list: D051017:Apoptosis Regulatory Proteins; D000072224:Bcl-2-Like Protein 11; C000606776:Bcl2l11 protein, mouse; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; D053148:Caspase 3