Urologic chronic pelvic pain syndrome--looking back and looking forward.
Urologic chronic pelvic pain syndrome (UCPPS) is a symptom-based umbrella term for interstitial cystitis/painful bladder syndrome (IC/PBS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men. Unfortunately, no gold standard for diagnosis or treatment of UCPPS exists. We review several emerging theories on the etiology and pathogenesis of UCPPS with a special emphasis on genomic and proteomic technologies. We also propose a systems-biology approach to elucidating the pathogenetic mechanisms implicated in UCPPS and the discovery and validation of new biomarkers for UCPPS. Using data gleaned from high-throughput genomic and proteomic screens can help develop effective treatments for this enigmatic chronic pelvic pain syndrome.
Dimitrakov
Jordan
J
Urological Diseases Research Center, Harvard Medical School, Children's Hospital, Boston, USA. Jordan.Dimitrakov@childrens.harvard.edu
Dimitrakova
Elena
E
D002908:Chronic Disease; D018856:Cystitis, Interstitial / Q000209:etiology; D023281:Genomics; D006801:Humans; D008297:Male; D017699:Pelvic Pain / Q000209:etiology*; D011472:Prostatitis / Q000209:etiology; D040901:Proteomics; D013577:Syndrome; D049490:Systems Biology