title: Successful treatment of refractory advanced nasal NK/T cell lymphoma with unrelated cord blood stem cell transplantation incorporating focal irradiation.
abstract: Nasal natural killer (NK)/T cell lymphoma is a rare disease with a poor prognosis. We report the case of a 52-year-old woman with progressive advanced nasal NK/T cell lymphoma, with local invasiveness and bone marrow involvement, who was successfully treated with unrelated cord blood transplantation (UCBT). The patient was initially refractory to conventional chemotherapy. She was therefore treated with local irradiation, which induced a partial response. The patient then underwent UCBT using a conditioning regimen consisting of cyclophosphamide and total body irradiation. Acute graft-versus-host disease involving the skin was observed, but it was well controlled without systemic administration of corticosteroids. The patient remained in complete remission for 18 months after UCBT. Although the observation period has been relatively short and longer follow-up is needed, our observations suggest that incorporating focal irradiation to conditioning regimen for local control might be an effective treatment option for advanced nasal NK/T cell lymphoma in the setting of UCBT.
authors: Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. velcade@intmed1.med.kyushu-u.ac.jp
authors: Yasuo
authors: Y
authors: Mori
authors: Takatoshi
authors: T
authors: Aoki
authors: Katsuto
authors: K
authors: Takenaka
authors: Takuji
authors: T
authors: Yamauchi
authors: Asataro
authors: A
authors: Yamamoto
authors: Kenjiro
authors: K
authors: Kamezaki
authors: Hiromi
authors: H
authors: Iwasaki
authors: Naoki
authors: N
authors: Harada
authors: Toshihiro
authors: T
authors: Miyamoto
authors: Koji
authors: K
authors: Nagafuji
authors: Takanori
authors: T
authors: Teshima
authors: Koichi
authors: K
authors: Akashi
mesh_terms: D003131:Combined Modality Therapy; D036101:Cord Blood Stem Cell Transplantation; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural; D054391:Lymphoma, Extranodal NK-T-Cell / Q000175:diagnosis / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009669:Nose Neoplasms / Q000628:therapy*; D049268:Positron-Emission Tomography; D012074:Remission Induction; D014057:Tomography, X-Ray Computed; D014916:Whole-Body Irradiation