title: The uleine-rich fraction of Himatanthus lancifolius blocks proliferative responses of human lymphoid cells.
abstract: The purpose of the present work is to report the effects shown by the uleine-rich fraction extracted from the barks of Himatanthus lancifolius (Muell. Arg.) Woodson (Apocynaceae) on human peripheral blood mononuclear cells in which we were able to inhibit the proliferation of phytohemagglutinin-stimulated lymphocytes by blocking their transformation into blast-dividing cells. Furthermore, it inhibited the proliferation of Daudi and Reh cells, two leukemic cell lines of lymphoid origin. The present study widens the biological applications of H. lancifolius' alkaloids to include its possible use as a modulator of the immune system.
authors: Laboratory of Hematology, Department of Medical Pathology, Federal University of Paraná, 80210-070 Curitiba, Brazil.
authors: Jeanine Marie
authors: JM
authors: Nardin
authors: Melissa Pires
authors: MP
authors: Lima
authors: Julio Cesar
authors: JC
authors: Machado
authors: Luciana Farhat
authors: LF
authors: Hilst
authors: Cid Aimbiré de Moraes
authors: CA
authors: Santos
authors: Almeriane Maria
authors: AM
authors: Weffort-Santos
mesh_terms: D000470:Alkaloids / Q000032:analysis / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000032:analysis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects*; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D001952:Bridged-Ring Compounds; D010936:Plant Extracts; C428545:uleine