Clinical use of botulinum toxins in oral and maxillofacial surgery.
Botulinum toxin (BTX) is a bacterial toxin that could be used as a medicine. Clinical applications of BTX have been expanding over the last 30 years and novel applications reported. Its mechanism of inhibiting acetylcholine release at neuromuscular junctions following local injection is unique for the treatment of facial wrinkles. Other dose-dependent anti-neuroinflammatory effects and vascular modulating properties have extended its spectrum of applications. Conditions such as temporomandibular joint disorders, sialorrhea, headache and neuropathic facial pain, muscle movement disorders, and facial nerve palsy could also be treated with this drug. Further applications of BTX are likely to be developed. This paper reviews the established and emerging applications of BTX in the field of oral and maxillofacial surgery. An overview of the pharmacology, toxicity and preparations of the agent is given.
Majid
O W
OW
Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Mosul, Mosul, Iraq. omerw_majid@yahoo.co.uk <omerw_majid@yahoo.co.uk>
D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D005155:Facial Nerve Diseases / Q000188:drug therapy; D005157:Facial Pain / Q000188:drug therapy; D005158:Facial Paralysis / Q000188:drug therapy; D006261:Headache / Q000188:drug therapy; D006801:Humans; D009069:Movement Disorders / Q000188:drug therapy; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D009469:Neuromuscular Junction / Q000187:drug effects; D019647:Oral Surgical Procedures / Q000379:methods*; D012798:Sialorrhea / Q000188:drug therapy; D013705:Temporomandibular Joint Disorders / Q000188:drug therapy
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A