Cytotoxic and anti-infective sesquiterpenes present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae).
A pharmacological screening of the ethanol extract and fractions of two Peruvian medicinal plants, Plagiochila disticha and Ambrosia peruviana, led to the isolation and characterization of three ENT-2,3-secoaromadendrane-type sesquiterpenoids, named plagiochiline A ( 1), I ( 2), and R ( 3), as well as of two pseudoguaianolids, damsin ( 4) and confertin ( 5), which exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 1, 4, and 5 were also investigated for their in vitro antileishmanial, trypanocidal, and antituberculosis activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes, as well as against MDR and sensitive strains of Mycobacterium tuberculosis, respectively.
Aponte
José C
JC
Department of Chemistry, University of Louisville, Louisville, KY 40292, USA.
Yang
Han
H
Vaisberg
Abraham J
AJ
Castillo
Denis
D
Málaga
Edith
E
Verástegui
Manuela
M
Casson
Lavona K
LK
Stivers
Nicole
N
Bates
Paula J
PJ
Rojas
Rosario
R
Fernandez
Irma
I
Lewis
Walter H
WH
Sarasara
César
C
Sauvain
Michel
M
Gilman
Robert H
RH
Hammond
Gerald B
GB
D000890:Anti-Infective Agents / Q000302:isolation & purification*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D019659:Asteraceae / Q000737:chemistry*; D052176:Azulenes / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D004852:Epoxy Compounds / Q000302:isolation & purification*; D006801:Humans; D010568:Peru; D010946:Plants, Medicinal / Q000737:chemistry; D011714:Pyrans / Q000302:isolation & purification*; D012717:Sesquiterpenes / Q000302:isolation & purification*
D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D052176:Azulenes; D004852:Epoxy Compounds; D011714:Pyrans; D012717:Sesquiterpenes; C012266:damsin; C012259:confertin; C089886:plagiochilin A