[Argyrophilic grain disease: synergistic component of dementia?].
BACKGROUND
Argyrophilic grain disease (AGD) is one cause of neurodegenerative dementia with a variable clinical spectrum. A neuropathology study is required for diagnosis.


METHODS
We report the case of a 68-year-old patient presenting with cognitive decline associating with frontal dysfunction and parkinsonism. Death occurred two years after onset. The neuropathology study revealed a status criblosus in the basal ganglia, neurofibrillary tangles and AGD.


CONCLUSIONS
We suggest that AGD could explain the atypical course of this dementia considering the fast cognitive decline, the clinical expression and the topography of the lesions.


CONCLUSIONS
This case illustrates the possible synergistic deleterious effect of this pathology on other causes of dementia.
Wallon
D
D
Service de Neurologie, Université de Rouen, CHU Charles-Nicolle, 1 Rue de Germont, 76031 Rouen Cedex, France. david.wallon@gmail.com
Sommervogel
C
C
Laquerrière
A
A
Martinaud
O
O
Lecourtois
M
M
Hannequin
D
D
D000368:Aged; D001479:Basal Ganglia / Q000473:pathology; D001480:Basal Ganglia Diseases / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D003071:Cognition / Q000502:physiology; D003704:Dementia / Q000473:pathology / Q000523:psychology*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D019636:Neurodegenerative Diseases / Q000473:pathology / Q000523:psychology*; D016874:Neurofibrillary Tangles / Q000473:pathology; D010300:Parkinson Disease / Q000150:complications / Q000523:psychology