title: A comparison of retinal prosthesis electrode array substrate materials.
abstract: Simulations of artificial vision suggest that 1000 electrodes may be required to restore vision to individuals with diseases of the outer retina. In order to achieve such an implant, new technology is needed, since the state-of-the-art implantable neural stimulator has at most 22 contacts with neural tissue. A critical component of this system is the multi-channel, stimulating electrode array. This array must meet very challenging, competing requirements for manufacturing, integration, surgical handling, and biocompatibility. Our lab has evaluated 3 polymers as retinal prosthesis substrates: polyimide, parylene, and silicone.
authors: Doheny Eye Institute, Los Angeles, California, USA.
authors: James D
authors: JD
authors: Weiland
authors: Mark S
authors: MS
authors: Humayun
authors: Helmut
authors: H
authors: Eckhardt
authors: Stefan
authors: S
authors: Ufer
authors: Lucien
authors: L
authors: Laude
authors: Brooke
authors: B
authors: Basinger
authors: Yu-Chong
authors: YC
authors: Tai
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D004285:Dogs; D004558:Electric Stimulation; D004566:Electrodes; D004567:Electrodes, Implanted; D004867:Equipment Design; D006801:Humans; D007834:Lasers; D011108:Polymers / Q000737:chemistry; D019736:Prostheses and Implants; D011474:Prosthesis Design; D012160:Retina / Q000601:surgery; D012164:Retinal Diseases / Q000601:surgery* / Q000628:therapy; D012171:Retinal Vessels / Q000601:surgery; D012828:Silicones / Q000737:chemistry; D013499:Surface Properties; D014992:Xylenes / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D012828:Silicones; D014992:Xylenes; C011055:parylene