title: Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum.
abstract: In this study, we evaluated haplotypes of the bovine FCGRT (encoding the FcRn heavy chain) and their relationship to the IgG concentration in bovine colostrum. Four single nucleotide polymorphism (SNP), classified into five haplotypes, were identified in a total of 49 Holstein-Frisians cows. Haplotype 5 was found to be significantly associated with a high IgG level ([OR] = 9.90, 95%CI = 1.11-88.34, p = 0.016) and haplotype 2 exhibited a similar trend ([OR] = 2.89, 95%CI = 1.17-7.11, p = 0.019).
authors: State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, People's Republic of China.
authors: Ran
authors: R
authors: Zhang
authors: Zhihui
authors: Z
authors: Zhao
authors: Yaofeng
authors: Y
authors: Zhao
authors: Imre
authors: I
authors: Kacskovics
authors: Marjolein van der
authors: Mv
authors: Eijk
authors: Nanda de
authors: Nd
authors: Groot
authors: Ning
authors: N
authors: Li
authors: Lennart
authors: L
authors: Hammarstrom
mesh_terms: D000483:Alleles; D000818:Animals; D002417:Cattle / Q000235:genetics* / Q000276:immunology; D003126:Colostrum / Q000737:chemistry* / Q000276:immunology; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D011961:Receptors, Fc / Q000235:genetics* / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I; D007074:Immunoglobulin G; D011961:Receptors, Fc; C100688:Fc receptor, neonatal