Protective effects of different antioxidants against endosulfan-induced oxidative stress and immunotoxicity in albino rats.
Endosulfan exposure (8 and 16 mg/kg) to rats significantly decreased the activities of superoxide dismutase and catalase, level of reduced glutathione and increased lipid peroxidation. The primary and secondary antiSRBC antibody titers, plaque forming cells counts and delayed hypersensivity reaction, and the TH1 or TH2 cytokines levels were significantly suppressed in a dose dependent manner. L-ascorbic acid and alpha-tocopherol produced a synergistic reversal of oxidative stress parameters following endosulfan exposure. N-acetylcysteine produced significant reversal of altered oxidative stress parameters and immune response after endosulfan exposure. A significant attenuation of the oxidative stress markers and immunotoxicity with a combined therapy of L-ascorbic acid plus alpha-tocopherol and with N-acetylcysteine was clearly demonstrated by the present results.
Pal
Rishi
R
Environmental Biochemistry and Immunology Laboratory, Department of Biochemistry, University College of Medical Sciences and G.T.B. Hospital (University of Delhi), Dilshad Garden, Delhi 110 095, India.
Ahmed
Tanzeel
T
Kumar
Vivek
V
Suke
Sanvidhan G
SG
Ray
Arunabha
A
Banerjee
B D
BD
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004726:Endosulfan / Q000633:toxicity*; D004912:Erythrocytes / Q000276:immunology; D005978:Glutathione / Q000378:metabolism; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D007306:Insecticides / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep; D013154:Spleen / Q000187:drug effects* / Q000276:immunology*; D013482:Superoxide Dismutase / Q000378:metabolism; D024502:alpha-Tocopherol / Q000494:pharmacology*
D000975:Antioxidants; D016207:Cytokines; D007306:Insecticides; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D024502:alpha-Tocopherol; D004726:Endosulfan; D001205:Ascorbic Acid