Minor secondary metabolic products from the stem bark of Plumeria rubra Linn. displaying antimicrobial activities.
Four new iridoids viz., plumeridoids A, B, and C and epiplumeridoid C were isolated from the stem bark of Plumeria rubra Linn. together with twenty-four known compounds viz., 1-( P-hydroxyphenyl)propan-1-one, isoplumericin, plumericin, dihydroplumericin, allamcin, fulvoplumerin, allamandin, plumieride, P- E-coumaric acid, 2,6-dimethoxy- P-benzoquinone, scopoletin, cycloart-25-en-3 beta,24-diol, 2,4,6-trimethoxyaniline, ajunolic acid, ursolic acid, oleanolic acid, beta-amyrin acetate, betulinic acid, lupeol and its acetate, 2,3-dihydroxypropyl octacosanoate, glucoside of beta-sitosterol, and a mixture of common sterols (stigmasterol and beta-sitosterol). Their structures were determined by means of spectroscopic data including HREIMS, 1H NMR, 13C NMR, 2D NMR (HMQC, HMBC, NOESY) and by comparison with published data. All but one of thirteen tested compounds exhibited antifungal, antialgal, and/or antibacterial activities.
Kuigoua
Guy Merlin
GM
Department of Chemistry, University of Paderborn, Paderborn, Germany.
Kouam
Simeon F
SF
Ngadjui
Bonaventure T
BT
Schulz
Barbara
B
Green
Ivan R
IR
Choudhary
M Iqbal
MI
Krohn
Karsten
K
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D039823:Iridoids / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry* / Q000378:metabolism; D018547:Plant Stems / Q000737:chemistry* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D039823:Iridoids