Intracerebral progression of Hodgkin lymphoma in a man with HIV.
Intracerebral relapse of Hodgkin lymphoma is a rare occurrence, with a reported incidence of < 0.5%. To the best of our knowledge, only 4 cases have been reported in the literature. We report the case of a human immunodeficiency virus (HIV)-seropositive man with disseminated Hodgkin lymphoma who presented with left facial weakness and sensory abnormalities as the only symptoms of disease progression 3 months after chemotherapy-induced disease remission. Because of the relative rarity of the condition, there are no randomized controlled trials or evidence-based strategies for managing patients with HIV and intracerebral Hodgkin lymphoma. The diagnostic difficulty of this case emphasizes the necessity for a high index of suspicion for the diagnosis of HIV-associated intracerebral lymphoma in the appropriate clinical setting. In the post-genomic era, the development of sophisticated clinical and/or molecular biomarkers could contribute to earlier diagnosis and potentially improve disease prognosis.
Saloura
Vassiliki
V
Department of Internal Medicine, Hahnemann University Hospital/Drexel University College of Medicine, Philadelphia, PA 19102, USA.
Grivas
Petros D
PD
Mapow
David
D
Kazmi
Khuran
K
Ward
Kristine
K
Styler
Michael
M
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy / Q000821:virology*; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D015658:HIV Infections / Q000150:complications*; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy / Q000821:virology*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D012008:Recurrence