[Contribution of molecular biology and Aspergillus galactomannan antigen assay for the diagnosis of histoplasmosis].
We report a case of a pulmonary histoplasmosis in an HIV-positive patient usually living in Cambodia, with a positive Aspergillus galactomannan antigenemia resulting from a cross-reaction, that decreased after antifungal therapy. We discuss the potential interest of the detection of fungal DNA by PCR and Aspergillus galactomannan antigenemia for the diagnosis of histoplasmosis, especially in countries where Histoplasma capsulatum antigen testing is not available.
Pineau
S
S
Service des Maladies Infectieuses et Tropicales, CHU Hôtel-Dieu, 1 place Alexis-Ricordeau, 44093 Nantes cedex 1, France.
Talarmin
J-P
JP
Morio
F
F
Grossi
O
O
Boutoille
D
D
Léauté
F
F
Le Pape
P
P
Gay-Andrieu
F
F
Miegeville
M
M
Raffi
F
F
D000946:Antigens, Fungal / Q000097:blood*; D001230:Aspergillus / Q000276:immunology*; D005690:Galactose / Q000031:analogs & derivatives; D006660:Histoplasmosis / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D008351:Mannans / Q000276:immunology*; D008875:Middle Aged; D008967:Molecular Biology
D000946:Antigens, Fungal; D008351:Mannans; C012990:galactomannan; D005690:Galactose