title: Fragmentation of calcified plaque after carotid artery stenting in heavily calcified circumferential stenosis.
abstract: BACKGROUND
  We assessed the morphological change of calcified plaque after carotid artery stenting (CAS) in vessels with heavily calcified circumferential lesions and discuss the possible mechanisms of stent expansion in these lesions.
  
  
  METHODS
  We performed 18 CAS procedures in 16 patients with severe carotid artery stenosis accompanied by plaque calcification involving more than 75% of the vessel circumference. All patients underwent multidetector-row computed tomography (MDCT) to evaluate lesion calcification before and within 3 months after intervention. The angiographic outcome immediately after CAS and follow-up angiographs obtained 6 months post-CAS were examined.
  
  
  RESULTS
  The preoperative mean arc of the calcifications was 320.1 +/- 24.5 degrees (range 278-360 degrees ). In all lesions, CAS procedures were successfully carried out; excellent dilation with residual stenosis <or=30% was achieved in all lesions. Post-CAS MDCT demonstrated multiple fragmentations of the calcifications in 17 of 18 lesions (94.4%), but only cracks in the calcified plaque without fragmentation in one (5.6%). Angiographic study performed approximately 6 months post-CAS detected severe restenosis in one lesion (5.6%) without fragmentation of calcified plaque.
  
  
  CONCLUSIONS
  Excellent stent expansion may be achieved and maintained in heavily calcified circumferential carotid lesions by disruption and fragmentation of the calcified plaques.
authors: Department of Neurosurgery and Neuroradiology, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
authors: Masanori
authors: M
authors: Tsutsumi
authors: Tomonobu
authors: T
authors: Kodama
authors: Hiroshi
authors: H
authors: Aikawa
authors: Masanari
authors: M
authors: Onizuka
authors: Minoru
authors: M
authors: Iko
authors: Kouhei
authors: K
authors: Nii
authors: Shuko
authors: S
authors: Hamaguchi
authors: Housei
authors: H
authors: Etou
authors: Kimiya
authors: K
authors: Sakamoto
authors: Ritsurou
authors: R
authors: Inoue
authors: Hiroya
authors: H
authors: Nakau
authors: Kiyoshi
authors: K
authors: Kazekawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography; D001807:Blood Vessel Prosthesis; D002114:Calcinosis / Q000000981:diagnostic imaging* / Q000601:surgery*; D016893:Carotid Stenosis / Q000000981:diagnostic imaging* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D015607:Stents; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome