Brain biomarkers of motor adaptation using phase synchronization.
A growing number of brain monitoring tools for medical and biomedical applications such as surgery have been developed. Although many assistive technologies (e.g., brain computer interface (BCI) systems) aiming to restore cognitive-motor deficits are under development, no functional neural indicator or brain biomarker able to track the cortical dynamics of the brain when interacting with new tools and/or novel environments in ecological situations are available. Therefore this study aimed to investigate potential biomarkers reflecting the dynamic cognitive-motor states of subjects who had to learn a new tool. These biomarkers were derived from phase synchronization measures of electroencephalographic (EEG) signals (coherence, phase locking value (PLV)). The findings indicate a linear decrease of phase synchronization for both movement planning and execution as subjects adapt during tool learning. These changes were correlated with enhanced kinematics as the task progressed. These non-invasive biomarkers may play a role in bioengineering applications and particularly in BCI systems, allowing the establishment of co-adaptation/cooperation between the user's brain and the decoding algorithm to design adaptive neuroprostheses.
Gentili
Rodolphe J
RJ
Department of Kinesiology and Graduate Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD 20742, USA. rodolphe@umd.edu
Bradberry
Trent J
TJ
Hatfield
Bradley D
BD
Contreras-Vidal
Jose L
JL
D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D003344:Cortical Synchronization; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D013647:Task Performance and Analysis