An [11]cytochalasin derivative from the marine-derived fungus Xylaria sp. PSU-F100.
A new [11]cytochalasin derivative, xylarisin (1), was isolated from the marine-derived fungus Xylaria sp. PSU-F100 along with six known metabolites: three mellein derivatives (2-4), one pyrone derivative (5) and two carboxylic acids (6,7). The structure and stereochemistry of 1 were determined by NMR and X-ray diffraction analyses. All isolated compounds showed mild antibacterial activity against standard Staphylococcus aureus ATCC 25923 and methicillin-resistant strain.
Rukachaisirikul
Vatcharin
V
Department of Chemistry and Center for Innovation in Chemistry, Prince of Songkla University, Hat Yai, Songkhla, Thailand. vatcharin.r@psu.ac.th
Khamthong
Nanthaphong
N
Sukpondma
Yaowapa
Y
Pakawatchai
Chaveng
C
Phongpaichit
Souwalak
S
Sakayaroj
Jariya
J
Kirtikara
Kanyawim
K
D018360:Crystallography, X-Ray; D003572:Cytochalasins / Q000737:chemistry* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012623:Seawater; D013098:Xylariales / Q000737:chemistry*
D003572:Cytochalasins; C547851:xylarisin