Timing matters.
Cells are entities in space and time. Systems biology strives to understand their composition, structural organization as well as dynamic behavior under different conditions. Here, measures for dynamic properties such as characteristic times, time hierarchy and time-dependent response are reviewed. Using a number of examples from yeast and micro-organism systems biology, the importance of considering the timing in experimental and theoretical research is discussed.
Klipp
Edda
E
Theoretical Biophysics, Humboldt-Universität Berlin, Berlin, Germany. edda.klipp@rz.hu-berlin.de
D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D049490:Systems Biology / Q000379:methods*; D013997:Time Factors; D015003:Yeasts / Q000378:metabolism*