title: Toxic effects of T-2 toxin on reproductive system in male mice.
abstract: The present study was conducted to evaluate the effects of T-2 toxin on semen quality, fertility and serum testosterone concentration in mice. Adult male mice were mated with sexually mature untreated female mice after being exposed to intraperitoneal injection of T-2 toxin at 0, 5, 10 or 15 mg/kg body weight daily for 7 successive days. Semen quality, serum testosterone concentration and fertility of treated mice were assessed. The results showed that the number of abnormal spermatozoa increased significantly and a significant decrease in spermatozoa with integrated acrosome was observed in males treated with T-2 toxin at all doses, As well, the amount of live spermatozoa decreased significantly in mice treated with 10 and 15 mg/kg body weight T-2 toxin. Low pregnancy rate and high fetal resorption rate were observed when females were mated with T-2 toxin-exposed males. Testicular and cauda epididymal sperm counts, efficiency of sperm production and serum testosterone concentration were significantly reduced in mice treated with T-2 toxin at all doses in a dose-dependent manner. In conclusion, these findings indicated that T-2 toxin presented toxic effects on reproductive system of adult male mice.
authors: College of Medical Technology and Engineering, Henan University of Science and Technology, Luo Yang, Henan 471003, China.
authors: Jian Ying
authors: JY
authors: Yang
authors: Yong Fa
authors: YF
authors: Zhang
authors: Ai Min
authors: AM
authors: Liang
authors: Xiang Feng
authors: XF
authors: Kong
authors: Yuan Xiao
authors: YX
authors: Li
authors: Kai Wang
authors: KW
authors: Ma
authors: Ai Hua
authors: AH
authors: Jing
authors: Shu Ying
authors: SY
authors: Feng
authors: Xiao Lan
authors: XL
authors: Qiao
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D012098:Reproduction / Q000187:drug effects*; D012661:Semen / Q000187:drug effects; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects; D013605:T-2 Toxin / Q000633:toxicity*; D013739:Testosterone / Q000097:blood; D018675:Toxicity Tests
chemical_list: D013739:Testosterone; D013605:T-2 Toxin