Deficits in the automatic activation of religious concepts in patients with Parkinson's disease.
Religion is central to the lives of billions of people worldwide. To probe processing dynamics of religious cognition and its potential brain correlates, we used a novel priming procedure to assess the integrity of religious and control semantic networks in patients with Parkinson's disease (PD) and controls. Priming for control, but not religious, concepts was intact in PD patients. Patients with left-onset (right-forebrain disease) evidenced severe impairment activating religious concepts. We next modeled the priming performance with modified cable equations. These analyses suggested that deficient performance of PD patients on activation of religious concepts was due to a change in the time constants governing gain and rate of decay of activation in these semantic networks. These modeling results are consistent with dopaminergic dysfunction in right-sided striatal-prefrontal networks. We conclude that right striatal-prefrontal dopaminergic networks support activation of complex religious concepts but not equally complex and related control concepts.
Butler
Paul M
PM
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA. pmbutler@bu.edu
McNamara
Patrick
P
Durso
Raymon
R
D001332:Automatism; D001921:Brain / Q000503:physiopathology*; D003342:Corpus Striatum / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000503:physiopathology; D012069:Religion and Psychology; D012720:Severity of Illness Index
D004298:Dopamine