title: Should we close hypoxaemic patent foramen ovale and interatrial shunts on a systematic basis?
abstract: BACKGROUND
  Rarely, hypoxaemia is associated with shunt reversal at the atrial level. Closure by interventional catheterization is the treatment of choice but indications and results have been studied insufficiently.
  
  
  OBJECTIVE
  To describe our experience with interventional closure of atrial right-to-left shunts described as hypoxaemic and the impact on patient oxygenation and clinical status.
  
  
  METHODS
  Retrospective study in two referral centres, including all patients undergoing closure of interatrial right-to-left shunt associated with hypoxaemia.
  
  
  RESULTS
  Since 2001, 21 consecutive patients underwent interventional shunt closure using the "Amplatzer((R)) device"; two patients had atrial septal defect and 19 had patent foramen ovale. Three patients had minor adverse events; two patients have a tiny residual shunt. Transcutaneous oxygen saturation and partial oxygen pressure increased significantly from 86+/-5 to 95+/-3% (p<0.001) and from 49.8+/-6.8 to 82.9+/-30.4mmHg (p=0.001), respectively. Seventeen (80%) patients reported clinical improvement. However, patients with chronic respiratory insufficiency remained more symptomatic, with three deaths after a median follow-up of 35 (6-97) months and 89% remaining in New York Heart Association class III/IV (vs 29% of patients without chronic respiratory insufficiency; p=0.035).
  
  
  CONCLUSIONS
  Hypoxaemic shunts are treated effectively by transcatheter closure, resulting in functional improvement in patients without respiratory insufficiency. When associated with chronic respiratory insufficiency, hypoxaemia often persists after shunt closure. In such cases, the right-to-left atrial shunt does not seem to be the main cause of hypoxaemia and the indication for closure is questionable.
authors: Service de cardiologie pédiatrique et congénitale, hôpital de la Timone-Enfants, rue Saint-Pierre, Marseille, France.
authors: Mohammad
authors: M
authors: El Tahlawi
authors: Bertrand
authors: B
authors: Jop
authors: Béatrice
authors: B
authors: Bonello
authors: Andreea
authors: A
authors: Dragulescu
authors: Francis
authors: F
authors: Rouault
authors: Gilbert
authors: G
authors: Habib
authors: Alain
authors: A
authors: Fraisse
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation*; D002908:Chronic Disease; D005260:Female; D054092:Foramen Ovale, Patent / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D005602:France / Q000453:epidemiology; D006344:Heart Septal Defects, Atrial / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D006439:Hemodynamics; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D018579:Patient Selection; D020127:Recovery of Function; D012131:Respiratory Insufficiency / Q000150:complications / Q000401:mortality; D012189:Retrospective Studies; D055989:Septal Occluder Device; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D010100:Oxygen