[Anti-alcoholic and anti-narcotic action of Methylobacteriim extorquens UCM B-3368].
The paper deals with action efficiency of microbial biomass on characteristic indicators at alcohol and morphine organism intoxication. The investigated microbial biomass affects the regulatory biochemical and physiological systems in experimental animals, normalizes activity of alcohol dehydrogenase and aldehide dehydrogenase, as well as the content of dophamine, disturbed under the effect of alcohol and morphine. Thus, the organism intoxication decreases. Except for the specific action, the above microbial biomass can be a source of protein, aminoacids, vitamins, microelements. So, the microbial preparation, made on its basis, can be used for the treatment of alcohol and morphine dependence in a form of biologically active dope. Thus the microbial drug intended for treatment of alcohol and opium dependence has been developed. One of its action mechanisms is based on the microorganisms capacity to transform alcohols and aldehides, owing to availability of alcohol and aldehide dehydrogenase, other its action mechanisms are at the stage of investigation.
Kryshtab
T P
TP
Romanovs'ka
V O
VO
Stohniĭ
N A
NA
Kovtun
T V
TV
Lebediev
D S
DS
Tyshchenko
H M
HM
D000426:Alcohol Dehydrogenase / Q000378:metabolism; D019973:Alcohol-Related Disorders / Q000201:enzymology / Q000378:metabolism / Q000517:prevention & control*; D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D000596:Amino Acids / Q000302:isolation & purification; D000818:Animals; D018533:Biomass; D002802:Cholinesterases / Q000378:metabolism; D019587:Dietary Supplements / Q000382:microbiology*; D004195:Disease Models, Animal; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D020601:Methylobacterium extorquens / Q000737:chemistry / Q000254:growth & development*; D009021:Morphine Dependence / Q000201:enzymology / Q000378:metabolism / Q000517:prevention & control*; D051381:Rats
D000596:Amino Acids; D008315:Malondialdehyde; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase; D002802:Cholinesterases