Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma.
Cutaneous T-cell lymphomas most commonly have a CD4(+) memory T-cell phenotype with relatively indolent course, but may in rare cases present with a CD8(+) cytotoxic phenotype exhibiting strikingly more aggressive clinical behavior. We present two cases of the clinically aggressive subtype of primary cutaneous epidermotropic CD8(+) cutaneous T-cell lymphoma and review the current literature, clinical behavior, and recommendations for treatment distinct from that of more common CD4(+) variants of cutaneous T-cell lymphoma.
Gormley
Rachel H
RH
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Hess
Stephen D
SD
Anand
Dipti
D
Junkins-Hopkins
Jacqueline
J
Rook
Alain H
AH
Kim
Ellen J
EJ
D000368:Aged; D000369:Aged, 80 and over; D000077610:Bexarotene; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003131:Combined Modality Therapy; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D008297:Male; D012867:Skin / Q000276:immunology; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D013764:Tetrahydronaphthalenes / Q000627:therapeutic use
D013764:Tetrahydronaphthalenes; D000077610:Bexarotene