[Detoxification gene polymorphisms and potential role of selection].
Based on published data on the occurrence of GST genes in various groups and populations, the authors have analyzed the potential role of polymorphism in the process of adaptation. The estimated dynamics of the occurrence of normal or deleted alleles makes it possible to assess a selection factor (S) in favor of heterozygotes / homozygotes by normal alleles. Its value can be 0.2-0.3.
Atniukova
O E
OE
Pakhomov
A Iu
AIu
Khandogina
E K
EK
D000222:Adaptation, Physiological / Q000235:genetics / Q000528:radiation effects*; D000293:Adolescent; D005787:Gene Frequency; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012641:Selection, Genetic
C413545:glutathione S-transferase T1; D005982:Glutathione Transferase