Rhabdomyolysis due to primary hyperaldosteronism.
Rhabdomyolysis may be secondary to trauma, excessive muscle activity, hereditary muscle enzyme defects and other medical causes. Primary hyperaldosteronism is characterised by hypertension, hypokalemia, suppressed plasma renin activity, and increased aldosterone excretion. Rhabdomyolysis is not common in primary hyperaldosteronism. We report here a 42-year-old woman presenting with rhabdomyolysis as heralding symptom of primary hyperaldosteronism. We also carried out a search of the literature to identify all cases of rhabdomyolysis as the first-recognized expression of a primary hyperaldosteronism. Sixteen cases met the criteria for inclusion. When rhabdomyolysis occurs in a patient with hypokalemia and metabolic alkalosis, primary hyperaldosteronism has to be suspected: if confirmed, an aldosterone-producing adenoma is the most probable cause.
Martínez
José Joaquín Alfaro
JJ
Sección de Endocrinología y Nutrición, Complejo Hospitalario Universitario de Albacete, Facultad de Medicina, Universidad de Castilla-La Mancha, Albacete, España. jalfaro@ono.com
Oliveira
Cristina Lamas
CL
Meneses
Amparo Lomas
AL
Rodríguez
Silvia Aznar
SA
Corrales
Pedro Pinés
PP
López
Antonio Hernández
AH
Romero
Francisco Botella
FB
D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D000315:Adrenalectomy; D000328:Adult; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006973:Hypertension / Q000209:etiology; D007008:Hypokalemia / Q000188:drug therapy / Q000209:etiology; D009123:Muscle Hypotonia / Q000209:etiology; D018908:Muscle Weakness / Q000209:etiology; D011188:Potassium / Q000627:therapeutic use; D012206:Rhabdomyolysis / Q000209:etiology*; D013148:Spironolactone / Q000627:therapeutic use
D013148:Spironolactone; D011188:Potassium