Identification and characterization of rabbit hemorrhagic disease virus genetic variants isolated in Korea.
Nine isolates of rabbit hemorrhagic disease virus (RHDV) were used for the genetic characterization of RHDV strains collected from rabbits in Korea between 2006 and 2008. A phylogenetic analysis of the complete VP60 region was performed and the sequences were divided mainly into two groups. The one group consisted of original RHDV and the other contained antigenic variant strain known as RHDVa strains. Most of the Korean isolates clustered with Chinese RHDV strains and belonged to the RHDVa subtype. A comparison of the amino acid sequences among RHDVa strains and original RHDV strains revealed significant substitutions of two amino acids in the A region, two in the B region, two in the F region, and nine amino acids in the E region. Taken together, the recent RHDVa strains have gradually replaced the original RHDV and are the predominant strains in Korea.
OEM
Jae-Ku
JK
National Veterinary Research and Quarantine Service, Ministry of Agriculture, Animal Disease Diagnostic Center Division, Anayang, Republic of Korea. jku0622@nvrqs.go.kr
LEE
Kwang-Nyeong
KN
ROH
In Soon
IS
LEE
Kyoung-Ki
KK
KIM
Seong-Hee
SH
KIM
Hye-Ryoung
HR
PARK
Choi-Kyu
CK
JOO
Yi-Seok
YS
D000595:Amino Acid Sequence; D000818:Animals; D017250:Caliciviridae Infections / Q000662:veterinary* / Q000821:virology; D014644:Genetic Variation; D017929:Hemorrhagic Disease Virus, Rabbit / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D011817:Rabbits; D056910:Republic of Korea / Q000453:epidemiology; D015678:Viral Structural Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D015678:Viral Structural Proteins; C081149:viral protein 60, rabbit hemorrhagic disease virus