title: Antiplaque and antigingivitis effect of Lippia Sidoides: a double-blind clinical study in humans.
abstract: OBJECTIVE
  The antiplaque and antigingivitis effect of Lippia Sidoides (LS) was evaluated in this in vivo investigation.
  
  
  METHODS
  Twenty-three subjects participated in a cross-over, double-blind clinical study, using 21-day partial-mouth experimental model of gingivitis. A toothshield was constructed for each volunteer, avoiding the brushing of the 4 experimental posterior teeth in the lower left quadrant. The subjects were randomly assigned initially to use either the placebo gel (control group) or the test gel, containing 10% LS (test group).
  
  
  RESULTS
  The clinical results showed statistically significant differences for plaque index (PLI) (p<0.01) between days 0 and 21 in both groups, however only the control group showed statistically significant difference (p<0.01) for the bleeding (IB) and gingival (GI) index within the experimental period of 21 days. On day 21, the test group presented significantly better results than the control group with regard to the GI (p<0.05).
  
  
  CONCLUSIONS
  The test gel containing 10% LS was effective in the control of gingivitis.
authors: University of Fortaleza, Fortaleza, CE, Brazil.
authors: Italo Sarto Carvalho
authors: IS
authors: Rodrigues
authors: Vinícius Nascimento
authors: VN
authors: Tavares
authors: Sérgio Luís da Silva
authors: SL
authors: Pereira
authors: Flávio Nogueira da
authors: FN
authors: Costa
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005260:Female; D005782:Gels; D005884:Gingival Hemorrhage / Q000517:prevention & control; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D032411:Lippia; D008297:Male; D009822:Oils, Volatile / Q000008:administration & dosage / Q000627:therapeutic use*; D010512:Periodontal Index; D008517:Phytotherapy; D010919:Placebos; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D005782:Gels; D009822:Oils, Volatile; D010919:Placebos; D010936:Plant Extracts