Pharmacological evaluation of novel indole-2-carboxamides as potent lipid-lowering agents in Triton-WR-1339-induced hyperlipidemic rats.
The lipid-lowering effects of two novel antihyperlipidemic agents, BMI2C [N-(4-benzoylphenyl)-5-methoxy-1H-indole-2-carboxamide] and DDMI2C [N-(9,10-dihydro-9,10-dioxoanthracen-2-yl)-5-methoxy-1H-indole-2-carboxamide], were studied using hyperlipidemic rats as an experimental model; hyperlipidemia was developed by intraperitoneal injection of Triton WR-1339 (200 mg/kg body weight). At a dose of 15 mg/kg body weight, BMI2C and DDMI2C significantly reduced elevated plasma triglyceride levels after 7 and 24 h. Furthermore, BMI2C and DDMI2C significantly reduced elevated plasma total cholesterol levels after 24 h. Interestingly, high-density lipoprotein-cholesterol levels were significantly increased in all treated groups. These findings indicate that the two studied novel compounds have a promising potential in the treatment of hyperlipidemia and atherosclerosis.
Al-Qirim
Tariq
T
Faculty of Pharmacy, Al-Zaytoonah Private University, Amman 11733, Jordan. qirim70@yahoo.com
Shahwan
Moyad
M
Shattat
Ghassan
G
Al-Hiari
Yusuf
Y
Abu-Sheikha
Ghassan
G
Zaidi
Syed
S
D000577:Amides / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D006949:Hyperlipidemias / Q000139:chemically induced / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood / Q000145:classification; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
D000577:Amides; D000960:Hypolipidemic Agents; D008055:Lipids; D011092:Polyethylene Glycols; C016811:tyloxapol