Metastasis of gestational trophoblastic neoplasia to the spinal canal: a case report.
BACKGROUND
Spinal canal metastasis secondary to gestational trophoblastic neoplasia (GTN) is a rare condition.


METHODS
A 21-year-old female presented with symptoms of cauda equina compression by an extradural metastasis from GTN. The patient received multiagent chemotherapy combined with intrathecal methotrexate administration. Her neurologic symptoms improved remarkably after the cessation of chemotherapy. During the 21-month follow-up period, she was asymptomatic and has shown overall improvement in well-being.


CONCLUSIONS
Spinal canal metastasis of GTN is a possibility that must be considered in young women with a history of hydatidiform mole who have neurologic symptoms or signs, which were improved completely by chemotherapy alone in this case.
Feng
Fengzhi
F
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, and Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China.
Xiang
Yang
Y
Cao
Yang
Y
D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood / Q000187:drug effects; D003609:Dactinomycin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage; D031901:Gestational Trophoblastic Disease / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000008:administration & dosage; D011247:Pregnancy; D013115:Spinal Canal / Q000473:pathology; D013125:Spinal Neoplasms / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D014594:Uterine Neoplasms / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D014750:Vincristine / Q000008:administration & dosage; D055815:Young Adult
D000970:Antineoplastic Agents; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005467:Floxuridine; D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D008727:Methotrexate