[The relationship between the expression of EGFR NF-kappaB and radiosensitivity in human nasopharyngeal carcinoma].
OBJECTIVE
To detect the expression of EGFR and NF-kappaB and the relationship between the two factors and radiosensitivity in human nasopharyngeal carcinoma.


METHODS
The expression of EGFR and NF-kappaB were detected with immunohistochemical staining SP methods in forty-one patients. The radiotherapy effect was assessed by follow up visit and clinical judgement. All of the forty-one patients were divided into three groups: the complete response group, the partial response (or the stable disease) group and the progressive disease group.


RESULTS
The expression of EGFR and NF-kappaB were detected in human nasopharyngeal carcinoma tissues, which were not in normal ones. EGFR and NF-kappaB were significant difference of the radiosensitivity in nasopharyngeal carcinoma tissues (P<0.05). The expression of EGFR and NF-kappaB in the complete response-group and the partial response (or the stable disease)-group were lower than the progressive disease-group (P<0.05), and there was no significant difference between the complete response-group and the partial response (or the stable disease)-group (P>0.05). The two factors' expression had negative correlation with radiosensitivity.


CONCLUSIONS
EGFR and NF-kappaB, as important targets, could predict the radiosensitivity of NPC, which could be helpful for targeting treatment and promote the effect of radiotherapy of NPC.
Yang
Chunni
C
Department of Otolaryngology, the First Affiliated Hospital of Kunming Medical College, Kunming.
Yang
Yibing
Y
Ai
Yiqin
Y
D000328:Adult; D000368:Aged; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000378:metabolism*; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy*; D011836:Radiation Tolerance; D055815:Young Adult
D016328:NF-kappa B; C512478:EGFR protein, human; D066246:ErbB Receptors