title: Decreased serum prolidase activity and increased oxidative stress in early pregnancy loss.
abstract: OBJECTIVE
  To compare the levels of serum prolidase activity and oxidative stress markers including total oxidative status (TOS), total antioxidant capacity (TAC), lipid hydroperoxide (LOOH) and total free sulfhydryl (-SH) in healthy pregnant women without early pregnancy loss (EPL) and women with EPL.
  
  
  METHODS
  Serum samples were obtained from 45 healthy first-trimester pregnancies and 45 pregnancies complicated with EPL. We have measured serum prolidase activity, TAC, TOS, -SH and LOOH levels spectrophotometrically.
  
  
  RESULTS
  Serum prolidase, TAC and -SH levels were significantly lower in the women with EPL than in the women without EPL (p <0.001, p = 0.001, p < 0.001, respectively), whereas TOS and LOOH levels were significantly higher (p < 0.001, p = 0.004, respectively). Prolidase activity was negatively correlated with TOS and LOOH levels (r = -0.299, p = 0.004; r = -0.323, p = 0.002, respectively), while positively correlated with TAC and -SH levels (r = 0.232, p = 0.028, and r = 0.418, p <0.001, respectively)
  
  
  CONCLUSIONS
  Findings of this study have shown that serum prolidase activity and oxidative stress are significantly associated with the presence of EPL, and the correlation between serum prolidase activity and the markers of oxidative stress was reflected in increased serum TOS and LOOH levels and decreased serum TAC and -SH levels.
authors: Department of Obstetrics and Gynecology, School of Medicine, Harran University, Yenisehir Kampusu No: 23/2, Sanliurfa, Turkey. haruntoy@hotmail.com
authors: Harun
authors: H
authors: Toy
authors: Hakan
authors: H
authors: Camuzcuoglu
authors: Aysun
authors: A
authors: Camuzcuoglu
authors: Hakim
authors: H
authors: Celik
authors: Nurten
authors: N
authors: Aksoy
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood / Q000201:enzymology*; D000328:Adult; D000975:Antioxidants / Q000032:analysis; D004150:Dipeptidases / Q000097:blood*; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D011247:Pregnancy; D018709:Statistics, Nonparametric; D013438:Sulfhydryl Compounds / Q000097:blood
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D013438:Sulfhydryl Compounds; D004150:Dipeptidases; C022449:proline dipeptidase