title: The effect of experimental diabetes on high mobility group box 1 protein expression in endotoxin-induced acute lung injury.
abstract: The incidence and prevalence of diabetes have recently increased. Hyperglycemia, which is commonly seen in intensive care medicine, is associated with increased morbidity and mortality. For instance, diabetes is associated with altered immune and hemostatic responses. High mobility group box 1 (HMGB1) protein plays a key role in various inflammatory diseases. This study investigated the increase in lung damage due to diabetes and the rise in HMGB1 levels in a lipopolysaccharide (LPS)-induced systemic inflammation rat model. Diabetes was induced by streptozotocin infusion 4 wk prior to LPS administration, followed by measurements of blood glucose and serum cytokine levels. Separate cohorts were sacrificed 12h post-LPS administration and analyzed for lung damage. Diabetic animals had significantly higher blood glucose and enhanced lung damage. In addition, levels of serum HMGB1, tumor necrosis factor-α, and interleukin-6 were increased in diabetic rats. Diabetes may exacerbate systemic inflammation as evidenced by higher serum HMGB1 and cytokine levels and enhanced lung damage in the rat systemic inflammation model.
authors: Department of Anesthesiology and Intensive Care Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan. saku@med.oita-u.ac.jp
authors: Satoshi
authors: S
authors: Hagiwara
authors: Hideo
authors: H
authors: Iwasaka
authors: Chihiro
authors: C
authors: Shingu
authors: Shigekiyo
authors: S
authors: Matumoto
authors: Akira
authors: A
authors: Hasegawa
authors: Takayuki
authors: T
authors: Noguchi
mesh_terms: D055371:Acute Lung Injury / Q000097:blood* / Q000139:chemically induced / Q000453:epidemiology*; D000818:Animals; D015897:Comorbidity; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000139:chemically induced / Q000453:epidemiology*; D004195:Disease Models, Animal; D004731:Endotoxins / Q000009:adverse effects; D024243:HMGB1 Protein / Q000097:blood*; D007328:Insulin / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000009:adverse effects; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D004731:Endotoxins; D024243:HMGB1 Protein; C104200:Hbp1 protein, rat; D007328:Insulin; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D013311:Streptozocin