title: A novel L-ascorbic acid and peptide conjugate with increased stability and collagen biosynthesis.
abstract: L-ascorbic acid (Vitamin C) and peptide are both useful compounds for collagen biosynthesis in cosmeceuticals (cosmetic and pharmaceutical fields). The instability of these compounds, however, limit their application in these industries. In this report, we describe the development of a novel compound, Stabilized Ascorbyl Pentapeptide (SAP), which physically is much more stable than L-ascorbic acid in water. The inhibitory effects of this SAP compound on tyrosinase and melanin synthesis is comparable to that of L-ascorbic acid. Importantly, the SAP compound displays no cytotoxicity at a high concentration (5 mM). The ability of SAP to promote collagen biosynthesis is greater than that of L-ascorbic acid or the KTTKS peptide alone. Considering the in vitro stability and functional effects, our data strongly suggest that the SAP compound is a good candidate not only as a cosmetic ingredient, but also as a wound healing agent.
authors: Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
authors: Ho-Il
authors: HI
authors: Choi
authors: Jong-Il
authors: JI
authors: Park
authors: Heung-Jae
authors: HJ
authors: Kim
authors: Dong-Won
authors: DW
authors: Kim
authors: Soung-Soo
authors: SS
authors: Kim
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003094:Collagen / Q000096:biosynthesis*; D008543:Melanins / Q000378:metabolism; D051379:Mice; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D010455:Peptides / Q000494:pharmacology*
chemical_list: D008543:Melanins; D010455:Peptides; D003094:Collagen; D014442:Monophenol Monooxygenase; D001205:Ascorbic Acid