title: Hydrolase-catalyzed fast Henry reaction of nitroalkanes and aldehydes in organic media.
abstract: Nitroalkanes underwent fast additions to a variety of structurally diverse aldehydes under the catalysis of d-aminoacylase in DMSO. The influences of reaction conditions including solvents, temperature, enzyme concentration and molar ratio of substrates were systematically investigated. Seventeen products were obtained in short time with moderate to high yields. It is the first report on hydrolase-catalyzed fast Henry reaction in organic solvent.
authors: Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang, PR China.
authors: Jun-Liang
authors: JL
authors: Wang
authors: Xia
authors: X
authors: Li
authors: Hong-Yan
authors: HY
authors: Xie
authors: Bo-Kai
authors: BK
authors: Liu
authors: Xian-Fu
authors: XF
authors: Lin
mesh_terms: D000447:Aldehydes / Q000378:metabolism*; D000473:Alkanes / Q000378:metabolism*; D001547:Benzaldehydes / Q000737:chemistry / Q000378:metabolism; D055162:Biocatalysis; D004980:Ethane / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D006867:Hydrolases / Q000378:metabolism*; D008956:Models, Chemical; D009574:Nitro Compounds / Q000378:metabolism*; D009595:Nitroparaffins / Q000737:chemistry / Q000378:metabolism; D012997:Solvents / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D000447:Aldehydes; D000473:Alkanes; D001547:Benzaldehydes; D009574:Nitro Compounds; D009595:Nitroparaffins; D012997:Solvents; C029915:4-nitrobenzaldehyde; C014705:nitroethane; D006867:Hydrolases; D004980:Ethane