title: Absence of the exon 1 coding sequence of the androgen receptor gene associated with teratozoospermia in a Brazilian population.
abstract: The androgen receptor (AR) is a protein encoded by the AR gene, which when mutated may affect spermatogenesis, the process in which spermatozoa are produced; thus, AR mutations could lead to male infertility. We examined exon 1 of the AR gene in men with idiopathic infertility. Blood or semen samples from 111 infertile, oligozoospermic (N = 31), asthenozoospermic (N = 23), teratozoospermic (N = 33), and azoospermic (N = 24) men were analyzed. The extracted DNA was amplified for the exon 1 region of the AR gene. There was a significant correlation between the absence of exon 1 in the AR gene and spermatogenesis defects (P = 0.015). This association was significant in teratozoospermic men (51.5% of the sample). We found that lack of amplification of exon 1 of the AR gene by polymerase chain reaction is associated with morphological defects in the spermogram.
authors: Departamento de Biologia, Universidade Católica de Goiás, Goiânia, GO, Brasil. wyara_castro@yahoo.com.br
authors: W E J C
authors: WE
authors: Mesquita
authors: M S
authors: MS
authors: Approbato
authors: K K V O
authors: KK
authors: Moura
authors: R S A
authors: RS
authors: Jesuíno
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000235:genetics*; D001938:Brazil; D005091:Exons; D006801:Humans; D008297:Male; D011944:Receptors, Androgen / Q000235:genetics*
chemical_list: D011944:Receptors, Androgen