title: Sinus floor augmentation surgery using autologous bone grafts from various donor sites: a meta-analysis of the total bone volume.
abstract: BACKGROUND
  To date, no studies have been published that evaluated histomorphometric data from a large number of patients while comparing different sites and methods of autologous bone grafting in sinus floor augmentation procedures. A meta-analysis of the English literature from January 1995 till April 2009 was carried out.
  
  
  METHODS
  PubMed search engine and the following journals were explored: Clinical Oral Implant Research, International Journal of Oral and Maxillofacial Implants, International Journal of Periodontics and Restorative Dentistry, and the Journal of Periodontology.
  
  
  RESULTS
  Out of 147 titles, according to our criteria, 25 articles were left for analysis. The majority were prospective controlled studies (21) and 2 randomized clinical trials, 1 pilot study and 1 case series. A reference value of 47% for total bone volume (TBV) was found while using iliac bone grafting as a standard. Use of intraoral bone grafts increases the TBV, with 11% for chin bone and 14% for bone grafted from other intraoral sites. Particulation of the bone graft has a negative effect on the TBV of 18%. Surprisingly, no correlation between TBV and the time of graft healing was found. Histological section thickness seemed to be a significant variable, as every micron increase of section thickness leads to an increase of 0.4% of TBV.
  
  
  CONCLUSIONS
  Bone grafting from the iliac crest resulted in a significantly lower TBV compared with intraoral bone grafting. However, due to the limited availability of intraoral bone to be harvested, iliac grafts still have to be considered the gold standard in augmenting the severely atrophic maxilla.
authors: Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors: Reinoud J
authors: RJ
authors: Klijn
authors: Gert J
authors: GJ
authors: Meijer
authors: Ewald M
authors: EM
authors: Bronkhorst
authors: John A
authors: JA
authors: Jansen
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods*; D016025:Bone Transplantation / Q000379:methods*; D001842:Bone and Bones / Q000166:cytology*; D002986:Clinical Trials as Topic / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D008443:Maxillary Sinus / Q000601:surgery*; D009929:Organ Size / Q000502:physiology; D014019:Tissue Donors / Q000706:statistics & numerical data; D014182:Transplantation, Autologous