title: Overcoming the drug resistance in breast cancer cells by rational design of efficient glutathione S-transferase inhibitors.
abstract: A new type of competitive human GST inhibitors has been developed via the bioisostere and structure activity profile strategies; we report their discovery, preparation, inhibitory activity, and synergetic effect in combination with chemotherapy drugs against breast cancer cells.
authors: Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan. wenshan@chem.sinica.edu.tw
authors: Wen-Shan
authors: WS
authors: Li
authors: Wing See
authors: WS
authors: Lam
authors: Kung-Cheng
authors: KC
authors: Liu
authors: Chie-Hong
authors: CH
authors: Wang
authors: Hui Chuan
authors: HC
authors: Chang
authors: Ya Ching
authors: YC
authors: Jen
authors: Yu-Ting
authors: YT
authors: Hsu
authors: Sachin S
authors: SS
authors: Shivatare
authors: Shu-Chuan
authors: SC
authors: Jao
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics; D015195:Drug Design; D019008:Drug Resistance, Neoplasm / Q000187:drug effects* / Q000235:genetics; D005260:Female; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D013329:Structure-Activity Relationship
chemical_list: D005982:Glutathione Transferase