Definition of reference ranges for the platelet distribution width (PDW): a local need.
BACKGROUND
Automated hematological analyzers have contributed to more precise and faster results. They also make it possible to measure several blood cell parameters automatically. Among the parameters provided, platelet indices are probably the most ignored by clinical laboratories due to the difficulty of standardization, as well as being affected by a range of methodological problems. It has been suggested that each laboratory determines its own reference intervals with the equipment used.


METHODS
Our goal was to determine the reference range of platelet distribution width (PDW) in venous blood samples from 231 patients using the Pentra 120 ABX hematology analyzer.


RESULTS
The PDW median was 13.3%, with a reference range of 10.0%-17.9% for the 5th-95th percentiles, with a confidence interval of 95%.


CONCLUSIONS
Among all indices, the PDW has been receiving attention due to its usefulness for distinguishing between reactive thrombocytosis and thrombocytosis associated with myeloproliferative disorder. Determination of the PDW reference range is fundamental, and the association of this parameter with the platelet number and mean platelet volume may be used for the diagnosis and differentiation of several pathologies.
Farias
Mariela Granero
MG
Unidade de Hematologia, Serviço de Patologia Clínica do Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. mg.farias@yahoo.com.br
Schunck
Elias Guilherme
EG
Dal Bó
Suzane
S
de Castro
Simone Martins
SM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000166:cytology*; D005260:Female; D006405:Hematology / Q000295:instrumentation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000097:blood / Q000175:diagnosis; D010976:Platelet Count / Q000295:instrumentation / Q000592:standards; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013922:Thrombocytosis / Q000097:blood / Q000175:diagnosis; D055815:Young Adult