title: Fosfluconazole for antifungal prophylaxis in very low birth weight infants.
abstract: We conducted a retrospective case series study to evaluate the safety of fosfluconazole prophylaxis for preventing invasive fungal infection in VLBW infants with a central vascular access. Fosfluconazole was administered intravenously at a dose of 6 mg/kg everyday during which time a central venous catheter was placed. A total of 23 infants met the criteria for enrollment in our study. No cases of fungal infection were detected during the central venous catheter placement in the group. None of the infants had an elevated beta-D-glucan, and all of them were still alive at discharge. Regarding the liver and renal function, no statistically significant differences were observed before and at the end of fosfluconazole prophylaxis. The results of this study demonstrate that fosfluconazole prophylaxis in preventing invasive fungal infection was well tolerated by VLBW infants. This is a first report to describe antifungal prophylaxis using fosfluconazole for VLBW infants.
authors: Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
authors: Daijiro
authors: D
authors: Takahashi
authors: Tomohiko
authors: T
authors: Nakamura
authors: Reiko
authors: R
authors: Shigematsu
authors: Miyu
authors: M
authors: Matsui
authors: Shunsuke
authors: S
authors: Araki
authors: Kazuyasu
authors: K
authors: Kubo
authors: Hiroshi
authors: H
authors: Sato
authors: Akira
authors: A
authors: Shirahata