De novo HLA sensitization and antibody mediated rejection following pregnancy in a heart transplant recipient.
Here we report a case wherein both donor-specific and third-party, paternal, HLA class II specific antibodies developed following a spontaneous miscarriage resulting in antibody-mediated rejection in a patient who had undergone an orthotopic cardiac transplant six years earlier.
O'Boyle
P J
PJ
Department of Cardiology, Harefield Hospital, Middlesex, UK.
Smith
J D
JD
Danskine
A J
AJ
Lyster
H S
HS
Burke
M M
MM
Banner
N R
NR
D000022:Abortion, Spontaneous / Q000209:etiology / Q000276:immunology; D000208:Acute Disease; D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006084:Graft Rejection / Q000209:etiology* / Q000276:immunology* / Q000473:pathology; D006680:HLA Antigens / Q000276:immunology*; D006681:HLA-D Antigens / Q000276:immunology; D006333:Heart Failure / Q000209:etiology; D016027:Heart Transplantation / Q000009:adverse effects* / Q000276:immunology* / Q000473:pathology; D006650:Histocompatibility Testing; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D018454:Spouses
D006680:HLA Antigens; D006681:HLA-D Antigens; D007519:Isoantigens