Fatty acids and immune function: relevance to inflammatory bowel diseases.
Fatty acids may influence immune function through a variety of mechanisms; many of these are associated with changes in fatty acid composition of immune cell membranes. Eicosanoids produced from arachidonic acid have roles in inflammation and immunity. Increased membrane content of n-3 fatty acids results in a changed pattern of production of eicosanoids, resolvins, and cytokines. Changing the fatty acid composition of immune cells also affects T cell reactivity and antigen presentation. Little attention has been paid to the influence of fatty acids on the gut-associated lymphoid tissue. However, there has been considerable interest in fatty acids and gut inflammation.
Calder
Philip C
PC
Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom. pcc@soton.ac.uk
D000818:Animals; D005227:Fatty Acids / Q000737:chemistry / Q000378:metabolism*; D015525:Fatty Acids, Omega-3 / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007109:Immunity / Q000276:immunology*; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000378:metabolism; D008954:Models, Biological; D015394:Molecular Structure; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D005227:Fatty Acids; D015525:Fatty Acids, Omega-3