Immune and virological benefits of 10 years of permanent viral control with antiretroviral therapy.
The effects of a 10-year control of HIV replication without viral blips with antiretroviral therapy were examined in progressors. CD4 cell counts did not plateau but showed a continuous increase until the 10th year. Ultrasensitive techniques showed very low plasma HIV RNA and cell-associated DNA levels. Robust memory T cell responses to HIV-p24 were higher than in 3-year treated patients and comparable to those of Elite controllers, whereas interferon-gamma-producing HIV-specific T cells were infrequent. Long-term and efficient antiretroviral therapy provides continuous benefits both on the immune system and on the HIV reservoirs.
Guihot
Amélie
A
UPMC Univ Paris 06, INSERM, UMR945, AP-HP, Laboratoire d'Immunologie Cellulaire et Tissulaire, Hôpital Pitié-Salpêtrière, Paris, France.
Tubiana
Roland
R
Breton
Guillaume
G
Marcelin
Anne-Geneviève
AG
Samri
Assia
A
Assoumou
Lambert
L
Goncalves
Emilia
E
Bricaire
François
F
Costagliola
Dominique
D
Calvez
Vincent
V
Rouzioux
Christine
C
Autran
Brigitte
B
Katlama
Christine
C
Carcelain
Guislaine
G
D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019562:Viral Load; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents