title: Nonpathogenesis of simian immunodeficiency virus infection is associated with reduced inflammation and recruitment of plasmacytoid dendritic cells to lymph nodes, not to lack of an interferon type I response, during the acute phase.
abstract: Divergent Toll-like receptor 7 (TLR7) and TLR9 signaling has been proposed to distinguish pathogenic from nonpathogenic simian immunodeficiency virus infection in primate models. We demonstrate here that increased expression of type I interferon in pathogenic rhesus macaques compared to nonpathogenic African green monkeys was associated with the recruitment of plasmacytoid dendritic cells in the lymph nodes and the presence of an inflammatory environment early after infection, instead of a difference in the TLR7/9 response.
authors: INSERM U841, Faculté Créteil Henri Mondor, 8 Rue du Général Sarrail, 94010 Créteil, France.
authors: Laure
authors: L
authors: Campillo-Gimenez
authors: Mireille
authors: M
authors: Laforge
authors: Michèle
authors: M
authors: Fay
authors: Audrey
authors: A
authors: Brussel
authors: Marie-Christine
authors: MC
authors: Cumont
authors: Valérie
authors: V
authors: Monceaux
authors: Ousmane
authors: O
authors: Diop
authors: Yves
authors: Y
authors: Lévy
authors: Bruno
authors: B
authors: Hurtrel
authors: John
authors: J
authors: Zaunders
authors: Jacques
authors: J
authors: Corbeil
authors: Carole
authors: C
authors: Elbim
authors: Jérôme
authors: J
authors: Estaquier
mesh_terms: D000210:Acute-Phase Reaction / Q000276:immunology / Q000473:pathology; D000818:Animals; D002465:Cell Movement; D002522:Chlorocebus aethiops; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D007370:Interferon Type I / Q000378:metabolism*; D016898:Interferon-alpha / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000473:pathology; D015302:Simian Immunodeficiency Virus / Q000276:immunology* / Q000472:pathogenicity*; D013045:Species Specificity; D051199:Toll-Like Receptor 7 / Q000378:metabolism; D051217:Toll-Like Receptor 9 / Q000378:metabolism; D014774:Virulence / Q000276:immunology
chemical_list: D007370:Interferon Type I; D016898:Interferon-alpha; D016209:Interleukin-8; D051199:Toll-Like Receptor 7; D051217:Toll-Like Receptor 9