title: Unexpected neoplasia in autopsies: potential implications for tissue and organ safety.
abstract: BACKGROUND
  -Medical examiner cases are increasingly used as tissue donor referral sources to meet the ever-growing need for transplant tissues. The assumption is often made that traumatic and sudden deaths have minimal risk of unsuspected neoplasia. An autopsy of a registered tissue donor with strong preautopsy clinical assessment of a saddle pulmonary embolus revealed unsuspected acute lymphoblastic leukemia, prompting a review of the incidence of unsuspected neoplasia from a regional forensic autopsy practice.
  
  
  OBJECTIVE
  -To determine the incidence of (1) unsuspected neoplasia, (2) clinical concordance of known neoplasia, and (3) potential donor referral in a regional forensic autopsy service.
  
  
  METHODS
  -A retrospective, 5-year review of 412 autopsies from a regional, primarily forensic, autopsy service to determine the incidence of unsuspected neoplasia, clinical concordance of known neoplasia, and the preautopsy assessment of potential donor referral suitability.
  
  
  RESULTS
  -Unsuspected neoplasia rate at autopsy was 7% (29 of 412 patients); cancer was the cause of death in 41% (12 of 29 patients) of these individuals. In patients with a history of cancer, the discordance of cancer diagnosis was 44% (4 of 9 patients [11 patients with known cancer, 2 who refused medical evaluation were excluded from the study]). Nearly 60% (17 of 29 patients) of the unsuspected cancer cases had no apparent reason for deferral of tissue procurement before the autopsy examination.
  
  
  CONCLUSIONS
  -The 7% incidence of unsuspected cancer in a forensic autopsy practice raises concern for the potential introduction of neoplastic tissue in the donor pool. To ensure the safety of this vital resource, mandatory complete autopsies on deceased donors are advocated as well as a tissue-recipient registry to track donor-related neoplasia.
authors: Department of Pathology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58202-9037, USA. msens@medicine.nodak.edu
authors: Mary Ann
authors: MA
authors: Sens
authors: XuDong
authors: X
authors: Zhou
authors: Timothy
authors: T
authors: Weiland
authors: A Marvin
authors: AM
authors: Cooley
mesh_terms: D000368:Aged; D001344:Autopsy / Q000379:methods / Q000706:statistics & numerical data*; D002423:Cause of Death; D003334:Coroners and Medical Examiners; D003645:Death, Sudden; D017809:Fatal Outcome; D005260:Female; D049429:Forensic Pathology / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000401:mortality; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000175:diagnosis*; D012189:Retrospective Studies; D014019:Tissue Donors