[Estimation on disease burden related to hepatitis B virus infection in Shandong province of China].
OBJECTIVE
To comprehensively measure the burden of hepatitis B, liver cirrhosis and liver cancer in Shandong province, using disability-adjusted life years (DALYs) to estimate the disease burden attribute to hepatitis B virus (HBV) infection.


METHODS
Based on the mortality data of hepatitis B, liver cirrhosis and liver cancer derived from the third National Sampling Retrospective Survey for Causes of Death during 2004 and 2005, the incidence data of hepatitis B and the prevalence and the disability weights of liver cancer gained from the Shandong Cancer Prevalence Sampling Survey in 2007, we calculated the years of life lost (YLLs), years lived with disability (YLDs) and DALYs of three diseases following the procedures developed for the global burden of disease (GBD) study to ensure the comparability.


RESULTS
The total burden for hepatitis B, liver cirrhosis and liver cancer were 211,616 (39,377 YLLs and 172,239 YLDs), 16,783 (13,497 YLLs and 3286 YLDs) and 247,795 (240,236 YLLs and 7559 YLDs) DALYs in 2005 respectively, and men were 2.19, 2.36 and 3.16 times as that for women, respectively in Shandong province. The burden for hepatitis B was mainly because of disability (81.39%). However, most burden on liver cirrhosis and liver cancer were due to premature death (80.42% and 96.95%). The burden of each patient related to hepatitis B, liver cirrhosis and liver cancer were 4.8, 13.73 and 11.11 respectively.


CONCLUSIONS
Hepatitis B, liver cirrhosis and liver cancer caused considerable burden to the people living in Shandong province, indicating that the control of hepatitis B virus infection would bring huge potential benefits.
Qi
Wen-Ting
WT
School of Public Health, Shandong University, Jinan, China.
Sun
Jian-Dong
JD
Xu
Ai-Qiang
AQ
Zhang
Li
L
Li
Ren-Peng
RP
Ma
Ji-Xiang
JX
Guo
Xiao-Lei
XL
Fan
Qing-Ying
QY
Yang
He
H
D002681:China / Q000453:epidemiology; D017281:Cost of Illness; D005260:Female; D006306:Health Surveys; D006509:Hepatitis B / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D015994:Incidence; D008017:Life Expectancy; D008103:Liver Cirrhosis / Q000453:epidemiology* / Q000401:mortality; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000401:mortality; D008297:Male; D015995:Prevalence; D019057:Quality-Adjusted Life Years; D012189:Retrospective Studies; D012737:Sex Factors