title: Increasing incidence of post-kala-azar dermal leishmaniasis in a population-based study in Bangladesh.
abstract: Post-kala-azar dermal leishmaniasis (PKDL) occurs after kala-azar treatment and acts as a durable infection reservoir. On the basis of active case finding among 22,699 respondents, 813 (3.6%) had had kala-azar since 2002, of whom 79 (9.7%) developed PKDL. Eight additional patients with PKDL had no history of kala-azar. Annual kala-azar incidence peaked at 85 cases per 10,000 person-years in 2004 and fell to 46 cases per 10,000 person-years in 2007, but PKDL incidence rose from 1 case per 10,000 person-years in 2002-2004 to 21 cases per 10,000 person-years in 2007. The rising PKDL incidence threatens the regional visceral leishmaniasis elimination initiative and underscores the urgent need for more effective PKDL diagnosis and treatment.
authors: International Centre for Diarrhoeal Disease Research, Bangladesh.
authors: Kazi Mizanur
authors: KM
authors: Rahman
authors: Shamim
authors: S
authors: Islam
authors: Muhammad Waliur
authors: MW
authors: Rahman
authors: Eben
authors: E
authors: Kenah
authors: Chowdhury Mohammad
authors: CM
authors: Ghalib
authors: Chowdhury Mohammad
authors: CM
authors: Galive
authors: M M
authors: MM
authors: Zahid
authors: James
authors: J
authors: Maguire
authors: Mahmudur
authors: M
authors: Rahman
authors: Rashidul
authors: R
authors: Haque
authors: Stephen P
authors: SP
authors: Luby
authors: Caryn
authors: C
authors: Bern
mesh_terms: D000293:Adolescent; D000328:Adult; D001459:Bangladesh / Q000453:epidemiology; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D015994:Incidence; D016773:Leishmaniasis, Cutaneous / Q000453:epidemiology* / Q000209:etiology; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000453:epidemiology*; D008297:Male; D011795:Surveys and Questionnaires