title: Quantitative measurements of absorption spectra in scattering media by low-coherence spectroscopy.
abstract: Low-coherence spectroscopy (LCS) is a spectroscopic method that allows for quantitative and localized assessment of absorption spectra by combining reflection spectroscopy with low-coherence interferometry. We describe absorption coefficient (mu(a)) measurements by LCS in tissue simulating phantoms with varying scattering and absorbing properties. We used LCS in the 455-680 nm wavelength range with a spectral resolution of 8 nm to obtain mu(a) spectra with +/-0.5 mm(-1) accuracy. We conclude that LCS is a promising technique for the in vivo determination of tissue chromophore concentrations.
authors: Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, P.O. Box 22700,NL-1100 DE Amsterdam, The Netherlands. n.bosschaart@amc.uva.nl
authors: Nienke
authors: N
authors: Bosschaart
authors: Maurice C G
authors: MC
authors: Aalders
authors: Dirk J
authors: DJ
authors: Faber
authors: Jelmer J A
authors: JJ
authors: Weda
authors: Martin J C
authors: MJ
authors: van Gemert
authors: Ton G
authors: TG
authors: van Leeuwen
mesh_terms: D000042:Absorption; D007368:Interferometry; D019047:Phantoms, Imaging; D011137:Polystyrenes / Q000737:chemistry; D012542:Scattering, Radiation; D013057:Spectrum Analysis / Q000379:methods*
chemical_list: D011137:Polystyrenes