Antiobesity mechanisms of action of conjugated linoleic acid.
Conjugated linoleic acid (CLA), a family of fatty acids found in beef, dairy foods and dietary supplements, reduces adiposity in several animal models of obesity and some human studies. However, the isomer-specific antiobesity mechanisms of action of CLA are unclear, and its use in humans is controversial. This review will summarize in vivo and in vitro findings from the literature regarding potential mechanisms by which CLA reduces adiposity, including its impact on (a) energy metabolism, (b) adipogenesis, (c) inflammation, (d) lipid metabolism and (e) apoptosis.
Kennedy
Arion
A
Department of Nutrition, University of North Carolina Greensboro, PO Box 26170, Greensboro, NC 27402-6170, USA.
Martinez
Kristina
K
Schmidt
Soren
S
Mandrup
Susanne
S
LaPoint
Kathleen
K
McIntosh
Michael
M
D050156:Adipogenesis; D050154:Adiposity; D000818:Animals; D017209:Apoptosis; D001835:Body Weight; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000378:metabolism; D019587:Dietary Supplements; D004734:Energy Metabolism; D006801:Humans; D007249:Inflammation; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage / Q000378:metabolism*; D050356:Lipid Metabolism; D009765:Obesity / Q000178:diet therapy*; D013045:Species Specificity
D004042:Dietary Fats, Unsaturated; D044243:Linoleic Acids, Conjugated