title: Innate versus acquired immune response in the pathogenesis of recurrent idiopathic pericarditis.
abstract: The pathogenesis of recurrent pericarditis is still poorly understood and may be related either to viral infections or autoimmune and autoinflammatory disorders. The immune system plays a major role in the pathogenesis of the disease, modulating individual responses to different noxa and explaining the variable reported recurrence rate (ranging from 20% to 50% of patients) following an attack of acute or recurrent pericarditis. Increasing interest is currently being devoted to autoinflammatory disorders, a group of conditions characterized by spontaneously relapsing and remitting bouts of systemic inflammation without apparent involvement of antigen-specific T cells or significant production of auto-antibodies. Ongoing basic and clinical research is needed to provide further evidence for the understanding of this common and troublesome disease, and to develop targeted and more efficacious therapies.
authors: Interdepartmental Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena, Italy. cantariniluca@hotmail.com
authors: Luca
authors: L
authors: Cantarini
authors: Cantarini
authors: C
authors: Luca
authors: Massimo
authors: M
authors: Imazio
authors: Imazio
authors: I
authors: Massimo
authors: Antonio
authors: A
authors: Brucato
authors: Brucato
authors: B
authors: Antonio
authors: Orso Maria
authors: OM
authors: Lucherini
authors: Lucherini Orso
authors: LO
authors: Maria
authors: Mauro
authors: M
authors: Galeazzi
authors: Galeazzi
authors: G
authors: Mauro
mesh_terms: D056704:Adaptive Immunity; D002311:Cardiomyopathy, Dilated / Q000209:etiology*; D010505:Familial Mediterranean Fever; D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate; D009205:Myocarditis / Q000150:complications / Q000235:genetics / Q000276:immunology*; D010496:Pericardium / Q000276:immunology*; D011110:Polymorphism, Genetic; D012008:Recurrence