Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs.
BACKGROUND
Genome-wide linkage studies for Alzheimer's disease have implicated several chromosomal regions as potential loci for susceptibility genes.


METHODS
In the present study, we have combined a selection of affected relative pairs (ARPs) from the UK and the USA included in a previous linkage study by Myers et al. (Am J Med Genet, 2002), with ARPs from Sweden and Washington University. In this total sample collection of 397 ARPs, we have analyzed linkage to chromosomes 1, 9, 10, 12, 19 and 21, implicated in the previous scan.


RESULTS
The analysis revealed that linkage to chromosome 19q13 close to the APOE locus increased considerably as compared to the earlier scan. However, linkage to chromosome 10q21, which provided the strongest linkage in the previous scan could not be detected.


CONCLUSIONS
The present investigation provides yet further evidence that 19q13 is the only chromosomal region consistently linked to Alzheimer's disease.
Blom
Elin S
ES
Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. elin.blom@pubcare.uu.se
Giedraitis
Vilmantas
V
Arepalli
Sampath
S
Hamshere
Marian L
ML
Adighibe
Omanma
O
Goate
Alison
A
Williams
Julie
J
Lannfelt
Lars
L
Hardy
John
J
Vrièze
Fabienne Wavrant-De
FW
Glaser
Anna
A
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D018895:Microsatellite Repeats; D008875:Middle Aged; D006113:United Kingdom; D014481:United States
D001057:Apolipoproteins E