title: Alcohol consumption and risk of incident human immunodeficiency virus infection: a meta-analysis.
abstract: OBJECTIVE
  To analyze the relationship between alcohol consumption and incident HIV infection.
  
  
  METHODS
  Articles were identified via electronic and hand searches. Inclusion criteria were: incident HIV infection, preceding alcohol consumption, and association relating the two. The DerSimonian and Laird random effects model was used. For studies with more than one estimate of a given type, estimates were combined using the inverse variance weighted method. Publication bias was assessed using Begg's and Egger's tests. Heterogeneity was assessed using Q and I (2) statistics.
  
  
  RESULTS
  Ten studies were included. Overall alcohol consumption (any of the three types identified) increased the risk of HIV (RR 1.98, 95% CI 1.59-2.47). Alcohol consumers were at 77% higher risk (RR 1.77, 95% CI 1.43-2.19). Those consuming alcohol prior to, or at the time of, sexual relations were at an 87% increased risk (RR 1.87, 95% CI 1.39-2.50). For binge drinkers, the risk was double that of non-binge drinkers (RR 2.20, 95% CI 1.29-3.74).
  
  
  CONCLUSIONS
  Alcohol consumption is associated with an increased risk of incident HIV infection. Additional research is required to further investigate a possible causal role.
authors: University of Toronto, 33 Russell St, Rm 2035, Toronto, ON M5S2S1, Canada. dolly.baliunas@utoronto.ca
authors: Dolly
authors: D
authors: Baliunas
authors: Jürgen
authors: J
authors: Rehm
authors: Hyacinth
authors: H
authors: Irving
authors: Paul
authors: P
authors: Shuper
mesh_terms: D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors; D055815:Young Adult