Vitamin B metabolism in Plasmodium falciparum as a source of drug targets.
The malaria parasite Plasmodium falciparum depends primarily on nutrient sources from its human host. Most compounds, such as glucose, purines, amino acids, as well as cofactors and vitamins, are abundantly available in the host cell, and can be readily salvaged by the parasite. However, in some cases the parasite can also synthesize cofactors de novo in reactions that appear to be essential. Importantly, the three biosynthetic pathways that produce vitamins B(1), B(6) and B(9) are absent from the host, but are well established in P. falciparum. This review summarizes and updates the current knowledge of vitamin B de novo synthesis and salvage in P. falciparum and focuses on their potential as targets for drug intervention.
Müller
Ingrid B
IB
Department of Biochemistry, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. ibmueller@bni-hamburg.de
Hyde
John E
JE
Wrenger
Carsten
C
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D016503:Drug Delivery Systems / Q000379:methods*; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000378:metabolism*; D014803:Vitamin B Complex / Q000378:metabolism*
D000962:Antimalarials; D014803:Vitamin B Complex