title: Angiogenesis inhibition by a lichen compound olivetoric acid.
abstract: Lichens have been used in folk medicine for centuries and are symbiotic organisms of fungi and algae that produce unique secondary metabolites. Olivetoric acid is one of these secondary metabolites. In the present study, the effect of olivetoric acid isolated from acetone extract of the lichen Pseudevernia furfuracea (var. ceratea) on angiogenesis was evaluated. It displayed potent anti-angiogenic activities in vitro: inhibited proliferation of rat adipose tissue endothelial cells (RATECs) and disrupted endothelial tube formation in a dose-dependent manner. Furthermore, dose-dependent depolymerization effects of olivetoric acid on F-actin stress fibers were observed. Decrease in the tube formation of RATECs by olivetoric acid might be explained by a disorganization of the actin cytoskeleton. These findings suggest that olivetoric acid is a new anti-angiogenic agent and can be developed as a new therapeutic agent for angiogenesis-related diseases.
authors: Department of Biology, Faculty of Science, Anadolu University, Eskişehir, Turkey. akoparal@anadolu.edu.tr
authors: A Tansu
authors: AT
authors: Koparal
authors: Gönül
authors: G
authors: Ulus
authors: Melih
authors: M
authors: Zeytinoğlu
authors: Turgay
authors: T
authors: Tay
authors: Ayşen Ozdemir
authors: AO
authors: Türk
mesh_terms: D000199:Actins / Q000187:drug effects; D000273:Adipose Tissue / Q000166:cytology; D020533:Angiogenesis Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D049109:Cell Proliferation; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000187:drug effects*; D008011:Lichens / Q000737:chemistry*; D051381:Rats; D012459:Salicylates / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000199:Actins; D020533:Angiogenesis Inhibitors; D012459:Salicylates; C514585:olivetoric acid