title: Rhabdomyolysis due to primary hyperaldosteronism.
abstract: Rhabdomyolysis may be secondary to trauma, excessive muscle activity, hereditary muscle enzyme defects and other medical causes. Primary hyperaldosteronism is characterised by hypertension, hypokalemia, suppressed plasma renin activity, and increased aldosterone excretion. Rhabdomyolysis is not common in primary hyperaldosteronism. We report here a 42-year-old woman presenting with rhabdomyolysis as heralding symptom of primary hyperaldosteronism. We also carried out a search of the literature to identify all cases of rhabdomyolysis as the first-recognized expression of a primary hyperaldosteronism. Sixteen cases met the criteria for inclusion. When rhabdomyolysis occurs in a patient with hypokalemia and metabolic alkalosis, primary hyperaldosteronism has to be suspected: if confirmed, an aldosterone-producing adenoma is the most probable cause.
authors: Sección de Endocrinología y Nutrición, Complejo Hospitalario Universitario de Albacete, Facultad de Medicina, Universidad de Castilla-La Mancha, Albacete, España. jalfaro@ono.com
authors: José Joaquín Alfaro
authors: JJ
authors: Martínez
authors: Cristina Lamas
authors: CL
authors: Oliveira
authors: Amparo Lomas
authors: AL
authors: Meneses
authors: Silvia Aznar
authors: SA
authors: Rodríguez
authors: Pedro Pinés
authors: PP
authors: Corrales
authors: Antonio Hernández
authors: AH
authors: López
authors: Francisco Botella
authors: FB
authors: Romero
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D000315:Adrenalectomy; D000328:Adult; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006973:Hypertension / Q000209:etiology; D007008:Hypokalemia / Q000188:drug therapy / Q000209:etiology; D009123:Muscle Hypotonia / Q000209:etiology; D018908:Muscle Weakness / Q000209:etiology; D011188:Potassium / Q000627:therapeutic use; D012206:Rhabdomyolysis / Q000209:etiology*; D013148:Spironolactone / Q000627:therapeutic use
chemical_list: D013148:Spironolactone; D011188:Potassium