Detection of a new yellow fever virus lineage within the South American genotype I in Brazil.
Nucleotide sequences of two regions of the genomes of 11 yellow fever virus (YFV) samples isolated from monkeys or humans with symptomatic yellow fever (YF) in Brazil in 2000, 2004, and 2008 were determined with the objective of establishing the genotypes and studying the genetic variation. Results of the Bayesian phylogenetic analysis showed that sequences generated from strains from 2004 and 2008 formed a new subclade within the clade 1 of the South American genotype I. The new subgroup is here designated as 1E. Sequences of YFV strains recovered in 2000 belong to the subclade 1D, which comprises previously characterized YFV strains from Brazil. Molecular dating analyses suggested that the new subclade 1E started diversifying from 1D about 1975 and that the most recent 2004-2008 isolates arose about 1985.
de Souza
Renato P
RP
Serviço de Virologia do Instituto Adolfo Lutz, São Paulo, SP, Brazil.
Foster
Peter G
PG
Sallum
Maria Anice M
MA
Coimbra
Terezinha L M
TL
Maeda
Adriana Y
AY
Silveira
Vivian R
VR
Moreno
Eduardo S
ES
da Silva
Fernanda G
FG
Rocco
Iray M
IM
Ferreira
Ivani B
IB
Suzuki
Akemi
A
Oshiro
Fabíola M
FM
Petrella
Selma M C N
SM
Pereira
Luiz E
LE
Katz
Giselda
G
Tengan
Cilea H
CH
Siciliano
Melissa M
MM
Dos Santos
Cecília L S
CL
D020413:3' Untranslated Regions / Q000235:genetics; D000818:Animals; D001499:Bayes Theorem; D001938:Brazil / Q000453:epidemiology; D019143:Evolution, Molecular; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D008992:Monkey Diseases / Q000453:epidemiology* / Q000821:virology; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D013020:South America; D014759:Viral Envelope Proteins; D015004:Yellow Fever / Q000453:epidemiology* / Q000662:veterinary / Q000821:virology; D015005:Yellow fever virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification
D020413:3' Untranslated Regions; D014759:Viral Envelope Proteins; C074932:prM protein, Flavivirus