Dietary resistant starch reduces histone acetylation on the glucose-dependent insulinotropic polypeptide gene in the jejunum.
We have reported that dietary resistant starch (RS) reduces glucose-dependent insulinotropic polypeptide (GIP) mRNA levels along the jejunoileum in both normal and diabetic rats. In this study, we found that jejunal reduction of the GIP gene by feeding normal rats dietary RS was associated with decreases in histone H3 and H4 acetylation on the promoter/enhancer region of the gene.
Shimada
Masaya
M
Laboratory of Nutritional Physiology, Graduate School of Nutritional and Environmental Sciences, Global COE Program, University of Shizuoka, Shizuoka-shi, Japan.
Mochizuki
Kazuki
K
Goda
Toshinao
T
D000107:Acetylation / Q000187:drug effects; D000818:Animals; D004032:Diet; D050991:GATA4 Transcription Factor / Q000378:metabolism; D005749:Gastric Inhibitory Polypeptide / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006657:Histones / Q000378:metabolism*; D007583:Jejunum / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D051381:Rats; D013213:Starch / Q000378:metabolism* / Q000494:pharmacology*
D050991:GATA4 Transcription Factor; D006657:Histones; D005749:Gastric Inhibitory Polypeptide; D013213:Starch