Asymmetric synthesis of anticancer beta-lactams via Staudinger reaction: utilization of chiral ketene from carbohydrate.
We describe herein asymmetric synthesis of a novel anticancer beta-lactam following Staudinger reaction with chiral carbohydrate as the ketene component with an achiral imine. The in vitro cytotoxicity studies of these beta-lactams are also reported here.
Banik
Bimal K
BK
Department of Chemistry, The University of Texas Pan American, 1201 West University Drive, Edinburg, TX 78539, USA. banik@panam.edu
Banik
Indrani
I
Becker
Frederick F
FF
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002241:Carbohydrates / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005030:Ethylenes / Q000737:chemistry*; D006801:Humans; D007659:Ketones / Q000737:chemistry*; D013237:Stereoisomerism; D047090:beta-Lactams / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D002241:Carbohydrates; D005030:Ethylenes; D007659:Ketones; D047090:beta-Lactams; C008223:ketene