Response of coronary heart disease risk factors to changes in body fat during diet-induced weight reduction in Japanese obese men: A pilot study.
OBJECTIVE
Serial measurements were used to examine the response of coronary heart disease (CHD) risk factors to regional fat changes during weight reduction.


METHODS
Nine Japanese obese men participated in a diet-induced weight loss program. Regional fat masses, abdominal visceral fat area (VFA), subcutaneous fat area (SFA) and CHD risk factors, including total (TC), high (HDLC)- and low-density lipoprotein cholesterol (LDLC), triglycerides (TG), fasting plasma glucose, immunoreactive insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and glycosylated hemoglobin A(1c) (HbA(1c)) were assessed at baseline and after 1, 2 and 3 months.


RESULTS
Meanweight reduction during the study was -11.9 +/- 4.2 kg, which was associated with a gradual, significant decrease (p < 0.05) in arm, leg and trunk fat masses, VFA and SFA. The levels of TC, LDLC and TG decreased significantly within 1 month and remained at these values, whereas HDLC, HOMA-IR, and HbA(1c) did not change. There was no significant correlation between changes in regional fat masses and CHD risk factors in any period studied.


CONCLUSIONS
CHD risk factors do not necessarily respond in the same manner as changes in body fat during diet-induced moderate weight reduction.
Ohkawara
Kazunori
K
National Institute of Health and Nutrition, Tokyo, Japan. ohkawara@nih.go.jp
Nakata
Yoshio
Y
Numao
Shigeharu
S
Sasai
Hiroyuki
H
Katayama
Yasutomi
Y
Matsuo
Tomoaki
T
Okura
Tomohiro
T
Tanaka
Kiyoji
K
D000328:Adult; D000886:Anthropometry; D050218:Body Fat Distribution; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D002149:Energy Intake; D015444:Exercise; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology / Q000628:therapy*; D012307:Risk Factors; D050151:Subcutaneous Fat / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
D002784:Cholesterol; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D014280:Triglycerides