Cell cycle regulators in the control of metabolism.
We recently showed that the CDK4-pRB-E2F1 cell cycle regulators directly regulate the expression of Kir6.2, which is a key component of the K(ATP) channel involved in the regulation of glucose-induced insulin secretion. There is enough evidence to indicate that the CDK4-pRB-E2F1 regulatory pathway is involved in general glucose homeostasis, and metabolism. In this article we discuss which are the metabolic implications of these findings.
Blanchet
Emilie
E
INSERM U896 and IRCM, Institut de Recherche en Cancérologie de Montpellier and University Montpellier 1, Montpellier, France.
Annicotte
Jean-Sébastien
JS
Fajas
Lluis
L
D017667:Adipocytes / Q000166:cytology* / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002453:Cell Cycle / Q000502:physiology*; D051358:Cyclin-Dependent Kinase 4 / Q000378:metabolism; D050687:E2F1 Transcription Factor / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology
D001786:Blood Glucose; D050687:E2F1 Transcription Factor; D051358:Cyclin-Dependent Kinase 4