Hypocupremia: an under recognized cause of subacute combined degeneration.
It is increasingly evident that a multitude of etiologies can give rise to signal abnormality in the dorsal and lateral columns of the spinal cord, apart from pernicious anemia. We report a case of dorsal and lateral columns signal abnormality related to hypocupremia resulting in progressive sensory ataxia and weakness in the lower and upper limbs, compounded by a recent diagnosis of Sjögren's syndrome.
Tan
Irene Y L
IY
Medical Imaging Department, St. Michael's Hospital, Toronto, Ontario, Canada.
de Tilly
Lyne Noël
LN
Gray
Trevor A
TA
D000368:Aged; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000008:administration & dosage; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D007706:Menkes Kinky Hair Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D052879:Subacute Combined Degeneration / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
D003300:Copper; D002570:Ceruloplasmin