title: Acute pulmonary toxicity following intralesional administration of bleomycin for a lymphovenous malformation.
abstract: OBJECTIVE
  To describe the clinical course and treatment of an infant with acute pulmonary toxicity following intralesional administration of bleomycin for a lymphovenous malformation.
  
  
  METHODS
  Case report.
  
  
  METHODS
  A tertiary care University-affiliated hospital.
  
  
  RESULTS
  An 8-month-old girl developed acute respiratory distress with profound hypoxemia complicated by pneumothorax and pneumomediastinum 1 day following intralesional administration of bleomycin. She was treated with bilateral chest tube insertion, systemic corticosteroids, pentoxifylline, and supportive care. At the most recent follow-up 5 months after the onset of the respiratory event, the patient is active, walks, and talks without any evidence of pulmonary diseases clinically. This is the youngest infant reported, to date, with acute bleomycin pulmonary toxicity following intralesional administration of bleomycin resulting in acute respiratory insufficiency followed by complete recovery.
  
  
  CONCLUSIONS
  This case illustrates the importance of early recognition and aggressive treatment of acute bleomycin toxicity resulting from intralesional administration of this medication for lymphovenous malformations.
authors: Pediatric Critical Care Medicine, Tawam Hospital in Affiliation with Johns Hopkins Medicine, Al Ain, United Arab Emirates.
authors: Khalid
authors: K
authors: Atwa
authors: Said
authors: S
authors: Abuhasna
authors: Zuhair
authors: Z
authors: Shihab
authors: Nidal
authors: N
authors: Hashaykeh
authors: Rashed
authors: R
authors: Hasan
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000402:Airway Obstruction / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007223:Infant; D015552:Injections, Intralesional; D044148:Lymphatic Abnormalities / Q000188:drug therapy*; D010431:Pentoxifylline / Q000627:therapeutic use; D011859:Radiography; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; D010431:Pentoxifylline