title: [The effect of high-fat diet and catch-up growth on gastric emptying and plasma glucagon-like peptide-1 concentration in rats].
abstract: OBJECTIVE
  To investigate the effect of high-fat diet and catch-up growth on gastric emptying and plasma glucagon-like peptide-1 (GLP-1) concentration in rats.
  
  
  METHODS
  Sixty SD rats were randomly divided into four groups, i. e. normal control group (NC group), refed with normal diet group (RN group), high fat diet group (HF group) and refed with high fat diet group (RH group). The weight and diet of rats were recorded. At the onset of refeeding (4 weeks ) and after 2 or 4 weeks of refeeding (6 or 8 weeks), animals were sacrificed and then gastric emptying study test and the assessment of plasma GLP-1 concentration were carried out.
  
  
  RESULTS
  Compared with NC group, rats in HF group possessed accelerated gastric emptying rate (95.61% vs 96.16%, 94.24% vs 96.11%, 93.08% vs 95.50%) and increased GLP-1 concentration (12.02 pmol/L vs 16.27 pmol/L, 10.77 pmol/L vs 13.93 pmol/L, 9.47 pmol/L vs 11.53 pmol/L) at 4, 6, 8 weeks respectively. Similarly, compared with NC group, RN group possessed slowed gastric emptying rate (95.61% vs 87.60%) and decreased GLP-1 concentration (12.02 pmol/L vs 9.69 pmol/L) at 4 weeks, but accelerated gastric emptying rate (94.24% vs 96.11%, 93.08% vs 94.52%) and increased GLP-1 concentration (10.77 pmol/L vs 12.57 pmol/L, 9.47 pmol/L vs 9.80 pmol/L) at 6 and 8 weeks respectively. Compared with HF group, RH group obtained slowed gastric emptying rate (96.16% vs 90.70%) and decreased GLP-1 concentration (16.27 pmol/L vs 9.69 pmol/L) at 4 weeks, but accelerated gastric emptying rate(96.11% vs 98.02%) and slightly lower GLP-1 concentration (13.93 pmol/L vs 13.44 pmol/L) at 6 weeks, and further slowed gastric emptying rate (96.50% vs 92.57%) and lower GLP-1 concentration (11.53 pmol/L vs 10.00 pmol/L).
  
  
  CONCLUSIONS
  Although both high-fat diet and catch-up growth affect the gastrointestinal function, the latter has a greater impact, which could account for some pathophysiological changes caused by catch-up growth.
authors: Department of Endocrinology, Xiehe Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China. cheria_chen@126.com
authors: Lu-Lu
authors: LL
authors: Chen
authors: Wei-Hong
authors: WH
authors: Yang
authors: Juan
authors: J
authors: Zheng
authors: Ling
authors: L
authors: Yue
authors: Xiang
authors: X
authors: Hu
mesh_terms: D000818:Animals; D004041:Dietary Fats; D005746:Gastric Emptying; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004041:Dietary Fats; D052216:Glucagon-Like Peptide 1