Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer.
BACKGROUND
The aim of this study was to estimate the relationship of glutathione S-transferases (GST)P1, GSTA1, GSTM1, and GSTT1 gene polymorphisms to oral cancer risk.


METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure these 4 gene polymorphisms in 274 controls and 164 oral cancer patients.


RESULTS
Individuals with at least 1 varied G allele of GSTP1 had a 1.53-fold risk (95% confidence interval [CI] = 1.01-2.31) of developing oral cancer compared with patients with wild-type A/A homozygotes. Oral cancer patients with at least 1 varied T allele of GSTA1 gene had a 0.42-fold risk (95% CI = 0.18-0.95) of having a tumor size >2 cm compared with patients with C/C homozygotes.


CONCLUSIONS
The varied G allele of GSTP1 may be considered as a factor contributing to increased susceptibility, whereas the T allele of GSTA1 could be a protective factor for tumor size progression in Taiwanese with oral cancer.
Chen
Mu-Kuan
MK
Department of Otorhinolaryngology-Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan.
Tsai
Hsiu-Ting
HT
Chung
Tsung-Te
TT
Su
Shih-Chi
SC
Kao
Te-Yu
TY
Tseng
Hsien-Chun
HC
Liu
Te-Hsiung
TH
Chiou
Hui-Ling
HL
Yang
Shun-Fa
SF
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology*; D009367:Neoplasm Staging; D011110:Polymorphism, Genetic / Q000235:genetics; D013624:Taiwan
D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1; C484555:GSTA1 protein, human; C496556:GSTP1 protein, human