title: Semi-synthesis of dihydrochalcone derivatives and their in vitro antimicrobial activities.
abstract: We describe the semi-synthesis of dihydrochalcone derivatives and their IN VITRO antimicrobial activities. These compounds were prepared by modifying two naturally occurring antimicrobial dihydrochalcones, erioschalcones A and B, reported by us earlier. The structures of the compounds were assigned on the basis of spectroscopic evidence and by comparing their physical and spectroscopic data with those reported in the literature. All the compounds were subjected to IN VITRO antimicrobial assays against a panel of pathogenic microorganisms, including gram-positive and gram-negative bacteria, and fungi. The antimicrobial efficacies of this class of compounds were established by correlating the activity profile of each compound with its structure and by comparing the activities of all the compounds with each other based on their structure. This should enable the development of other derivatives of the dihydrochalcone family that would serve as more potent antimicrobial agents against specific pathogens.
authors: Laboratory of Natural Products Chemistry, Department of Chemistry, University of Dschang, Dschang, Cameroon.
authors: Maurice D
authors: MD
authors: Awouafack
authors: Souvik
authors: S
authors: Kusari
authors: Marc
authors: M
authors: Lamshöft
authors: Dieudonne
authors: D
authors: Ngamga
authors: Pierre
authors: P
authors: Tane
authors: Michael
authors: M
authors: Spiteller
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D047188:Chalcones / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D047188:Chalcones; C015812:dihydrochalcone