[Analysis of clinical risk factors in progression from acute lung injury to acute respiratory distress syndrome in severe trauma patients].
OBJECTIVE
To investigate the potential risk factors of affecting progression from acute lung injury (ALI) to acute respiratory distress syndrome in severe trauma population.


METHODS
Twenty potential risk factors of affecting progression of acute lung injury were examined by univariate and multivariate logistic analyses among the severe trauma patients in a retrospective study.


RESULTS
All of 375 specially severe trauma patients with ALI were included for analysis. The six risk factors that affected the progression from acute lung injury to acute respiratory distress syndrome were sepsis, duration of trauma, APACHE II score, DIC, aspiration of gastric contents, and advanced age. Specific risk factors also affected different patient subpopulations at different degrees.


CONCLUSIONS
Impact of sepsis, DIC and duration of trauma that predict progression of ALI exists throughout the entire treatment period while aspiration of gastric contents and APACHE II score might affect aggravation of ALI only during the early period; due to deterioration of pulmonary function and severely traumatic injury, advanced age is still an independent risk factor; patients with these risk factors need aggressive supportive cares as early as possible in order to prevent further aggravations.
Wu
Jun-song
JS
Emergency Department, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. wjs128@sohu.com
Sheng
Lei
L
Ma
Yue-feng
YF
Wang
Shen-hua
SH
Zhou
Wen
W
Chen
Jin-ming
JM
Zhang
Mao
M
Xu
Shao-wen
SW
Jiang
Guan-yu
GY
D000063:Accidents, Traffic; D055371:Acute Lung Injury / Q000150:complications*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D012128:Respiratory Distress Syndrome / Q000175:diagnosis / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors