title: Endothelial dysfunction is associated with increased levels of biomarkers in essential hypertension.
abstract: To assess the correlation between endothelial dysfunction and the serum levels of biomarkers of inflammation, remodelling and oxidative stress in essential hypertension, 78 treatment-naïve essential hypertensives (mean age 43 years) underwent measurement of endothelial dysfunction, using the maximal acetylcholine-induced forearm vasodilation and serum levels of adhesion molecules, selectins, chemokines, metalloproteinases, copper, zinc, selenium, vitamins, homocysteine, malondialdehyde, erythrocyte glutathione peroxidase and erythrocyte superoxide dismutase. Mean (+/-s.e.m.) maximal acetylcholine-induced vasodilation was 367+/-20%. Patients with a more impaired acetylcholine-dependent vasodilation (first tertile) had increased levels of e-selectin (P=0.009), p-selectin (P<0.001), monocyte chemotactic protein type 1 (MCP-1; P=0.012) and the tissue inhibitor of metalloproteinases type 1 (TIMP-1; P=0.044), which in turn showed significant inverse correlations with maximal endothelium-dependent vasodilation. Serum levels of selenium (P=0.012), vitamin C (P=0.038), erythrocyte glutathione peroxidase (P<0.001) and superoxide dismutase (P=0.022) activities were reduced in patients with a more impaired endothelium-dependent vasodilation. Recently diagnosed treatment-naïve essential hypertensives showed a relationship between the endothelial dysfunction, serum markers of inflammation and remodelling and levels of antioxidant substances. These could be potentially helpful markers of high risk in hypertensive patients.
authors: Department of Internal Medicine, Hospital Mutua Terrassa, University of Barcelona, Terrassa, Spain. adelasierra@mutuaterrassa.es
authors: A
authors: A
authors: de la Sierra
authors: M
authors: M
authors: Larrousse
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood; D018925:Chemokines / Q000097:blood; D003300:Copper / Q000097:blood; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006710:Homocysteine / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D045726:Metalloproteases / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D012307:Risk Factors; D019087:Selectins / Q000097:blood; D012643:Selenium / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood; D014657:Vasculitis / Q000097:blood / Q000503:physiopathology*; D014664:Vasodilation / Q000187:drug effects*; D014815:Vitamins / Q000097:blood; D015032:Zinc / Q000097:blood
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; D018925:Chemokines; D019087:Selectins; D014815:Vitamins; D006710:Homocysteine; D008315:Malondialdehyde; D003300:Copper; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D045726:Metalloproteases; D012643:Selenium; D015032:Zinc; D000109:Acetylcholine