title: Diagnostic imaging of esophageal epithelium with clinical endoscopic polarized scanning spectroscopy instrument.
abstract: This letter reports the development of an endoscopic polarized scanning spectroscopy (EPSS) instrument compatible with existing endoscopes. This instrument uses light scattering spectroscopy (LSS). In proof-of-principle studies using a single-point instrument, LSS has successfully demonstrated the ability to identify pre-cancer in the epithelial tissues of five different organs, including Barrett's esophagus (BE). The EPSS instrument can provide real time in vivo information on the location of otherwise invisible high grade dysplasia (HGD), a predictor of adenocarcinoma, and thus can serve as a guide for biopsy. It should greatly reduce the time and labor involved in performing screening and obtaining diagnoses, cause less patient discomfort and ensure that fewer biopsies are required for the reliable location of pre-cancerous lesions.
authors: Department of Obgyn and Reproductive Biology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA.
authors: Le
authors: L
authors: Qiu
authors: Ram
authors: R
authors: Chuttani
authors: Songhua
authors: S
authors: Zhang
authors: Jun
authors: J
authors: Feng
authors: Sara
authors: S
authors: Itani
authors: Hui
authors: H
authors: Fang
authors: Douglas
authors: D
authors: Pleskow
authors: Mandeep S
authors: MS
authors: Sawhney
authors: Saira
authors: S
authors: Salahuddin
authors: Mark D
authors: MD
authors: Modell
authors: Edward
authors: E
authors: Vitkin
authors: Eugene B
authors: EB
authors: Hanlon
authors: Irving
authors: I
authors: Itzkan
authors: Lev T
authors: LT
authors: Perelman
mesh_terms: D001471:Barrett Esophagus / Q000473:pathology*; D001706:Biopsy; D003952:Diagnostic Imaging; D004847:Epithelial Cells / Q000473:pathology; D004867:Equipment Design; D004938:Esophageal Neoplasms / Q000473:pathology*; D004945:Esophagoscopy / Q000379:methods*; D005336:Fiber Optic Technology; D006801:Humans; D008859:Microscopy, Polarization / Q000295:instrumentation / Q000379:methods*; D015203:Reproducibility of Results; D013057:Spectrum Analysis / Q000379:methods