title: Colloid vs. crystalloid infusions in gastrointestinal surgery and their different impact on the healing of intestinal anastomoses.
abstract: BACKGROUND
  The aim of this study was to investigate if colloid infusions have different effects on intestinal anastomotic healing when compared to crystalloid infusions depending on the amount of the administered volume.
  
  
  METHODS
  Twenty-eight Wistar rats were randomly assigned to four groups receiving different amounts of either a crystalloid (Cry) or a colloid (Col) infusion solution. Animals with volume restriction (Cry (-) or Col (-)) were treated with a low and animals with volume overcharge (Cry (+) or Col (+)) with a high flow rate. All animals received an infusion for a 60-min period, while an end-to-end small bowel anastomosis was performed. At reoperation, the anastomotic bursting pressure (millimeters of mercury) was measured, as well as anastomotic hydroxyproline concentration. The presence of bowel wall edema was assessed histologically.
  
  
  RESULTS
  Median bursting pressures were comparable in the Col (-) [118 mm Hg (range 113-170)], the Cry (-) [118 mm Hg (78-139)], and the Col (+) [97 mm Hg (65-152)] group. A significantly lower median bursting pressure was found in animals with crystalloid volume overload Cry (+) [73 mm Hg (60-101)]. Corresponding results were found for hydroxyproline concentration. Histology revealed submucosal edema in Cry (+) animals.
  
  
  CONCLUSIONS
  In case of a fixed, high-volume load, colloids seem to have benefits on intestinal anastomotic healing when compared to crystalloid infusions.
authors: Department of Surgery, University of Freiburg, Freiburg, Germany. goran.marjanovic@uniklinik-freiburg.de
authors: Goran
authors: G
authors: Marjanovic
authors: Christian
authors: C
authors: Villain
authors: Sylvia
authors: S
authors: Timme
authors: Axel
authors: A
authors: zur Hausen
authors: Jens
authors: J
authors: Hoeppner
authors: Frank
authors: F
authors: Makowiec
authors: Philipp
authors: P
authors: Holzner
authors: Ulrich Theodor
authors: UT
authors: Hopt
authors: Robert
authors: R
authors: Obermaier
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods*; D000818:Animals; D003102:Colloids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000077324:Crystalloid Solutions; D013505:Digestive System Surgical Procedures / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004487:Edema; D006909:Hydroxyproline; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011312:Pressure; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D003102:Colloids; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D006909:Hydroxyproline