French recommendations on the management of invasive cervical cancer during pregnancy.
BACKGROUND
Cervical cancer is one of the most frequently diagnosed cancers during pregnancy, but the management of such cases remains unclear. A Working Group was set up in 2007 in France to propose national recommendations for the management of pregnant patients with invasive cervical carcinoma.


METHODS
The recommendations are based on this literature review conducted by the members of the Working Group.


RESULTS
Management of cervical cancer during pregnancy depends on 5 factors: stage of the disease (and the tumor size), nodal status, histological subtype of the tumor, term of the pregnancy, and whether the patient wishes to continue her pregnancy. In patients with early-stage disease diagnosed during the first 2 trimesters of pregnancy, there is an increasing tendency to preserve the pregnancy while awaiting fetal maturity in patients with absence of nodal involvement. The delivery (when the fetal maturity is attained) should be then performed using a cesarean section.


CONCLUSIONS
This article proposes recommendations for the management of pregnant patients with invasive cervical cancer. These recommendations have been validated by the 3 main scientific societies of gynecologic oncology, pelvic surgery, and obstetrics and gynecology in France.
Morice
Philippe
P
Department of Surgery, Institut Gustave Roussy, Villejuif, France. morice@igr.fr
Narducci
Febrice
F
Mathevet
Patrice
P
Marret
Henri
H
Darai
Emile
E
Querleu
Denis
D
D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D005260:Female; D005602:France; D005865:Gestational Age; D006287:Health Planning Guidelines; D006801:Humans; D009361:Neoplasm Invasiveness; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*