title: Association of abnormal vaginal flora and Ureaplasma species as risk factors for preterm birth: a cohort study.
abstract: OBJECTIVE
  To find out whether the presence of Ureaplasma species (U. spp.) in combination with an alteration of the normal vaginal flora is an independent risk factor for preterm delivery.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  Department of Obstetrics, University Hospital in Brussels.
  
  
  METHODS
  A total of 1,988 singleton pregnancies were included.
  
  
  METHODS
  From each woman, a cervical culture for U. spp. was obtained and the vaginal flora evaluated at the first prenatal visit. The presence of known risk factors for preterm delivery was recorded. Preterm birth was defined as delivery < 37 weeks.
  
  
  RESULTS
  There were 97 (4.9%) preterm births. In patients delivered before 37 weeks, abnormal vaginal flora was detected in 22.7% and U. spp. in 53.6% of these. The conditions were found together in 17.5%. In patients delivered at term, an abnormal vaginal flora was detected in 14.4% and U. spp. in 41.4% of these women, while they co-existed in 8.2%. Using a logistic regression analysis taking into account known risk factors for preterm birth and the microbiological parameters, preterm delivery was correlated with the presence of U. spp. (odds ratio (OR) 1.64; 95% confidence interval (CI) 1.08-2.48; p = 0.02) and abnormal vaginal flora in combination with U. spp. (OR 2.35; 95% CI 1.35-4.10; p = 0.003). No significant correlation between the presence of abnormal vaginal flora and preterm delivery (p = 0.09) was found.
  
  
  CONCLUSIONS
  Preterm delivery was significantly correlated with the presence of U. spp. The risk for preterm delivery increased when U. spp. was associated with an abnormal vaginal flora.
authors: Department of Obstetrics, University Hospital, Free University Brussels, Laarbeeklaan 1011090, Brussels, Belgium. mbreugel@uzbrussel.be
authors: Maria
authors: M
authors: Breugelmans
authors: Ellen
authors: E
authors: Vancutsem
authors: Anne
authors: A
authors: Naessens
authors: Monica
authors: M
authors: Laubach
authors: Walter
authors: W
authors: Foulon
mesh_terms: D001530:Belgium / Q000453:epidemiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors; D016869:Ureaplasma Infections / Q000453:epidemiology*; D014621:Vagina / Q000382:microbiology*