Mitosis: too much of a good thing (can be bad).
Recent studies reveal that the precise regulation of microtubule dynamics is essential for an error-free mitosis. Kinetochore microtubule attachments that are too stable increase the rate of chromosome mis-segregation, a leading cause of chromosomal instability in tumors.
Khodjakov
Alexey
A
Wadsworth Center, Albany, NY 12201-0509, USA. khodj@wadsworth.org
Rieder
Conly L
CL
D043171:Chromosomal Instability; D006801:Humans; D018386:Kinetochores; D008870:Microtubules; D008938:Mitosis