[Expression and significance of CD147 protein in prostate cancer].
OBJECTIVE
To investigate the expression of CD147 in prostate cancer and discuss its diagnostic value in prostate cancer.


METHODS
The method of immunohistochemical SP was employed to detect the expression of CD147 in 101 cases of prostate cancer, 90 cases of benign prostatic hyperplasia, 36 cases of normal prostate and 15 cases of embryonic prostate by so as to evaluate its clinical significance in the histological classification and prognosis of prostate cancer.


RESULTS
The CD147 expression was positively expressed in 67/101 (66.3%) of prostate cancer, 21/90 (23.3%) of benign prostatic hypertrophy, 2/36 (5.6%) of normal prostate and 0/15 (0.0) of embryonic prostate respectively. A positive expression of CD147 was dramatically associated with TNM stage (P < 0.001), the depth of prostatic capsule invasion (P = 0.002) and histological grade (P = 0.006).


CONCLUSIONS
The detection of CD147 is helpful to raise the early diagnosis rate of prostate cancer. It will become a tumor marker of reflecting the malignant degree and predicting the prognosis of prostate cancer.
He
Hui-Chan
HC
Department of Urology, First Municipal People's Hospital Affiliated to Guangzhou Medical College, Guangzhou 510182, China.
Han
Zhao-Dong
ZD
Dai
Qi-Shan
QS
Zou
Jun
J
Zhang
Yang
Y
Zhang
Zheng
Z
Liang
Yu-Xiang
YX
Ye
Yong-Kang
YK
Chen
Zhi-Nan
ZN
Zhong
Wei-De
WD
D000368:Aged; D051926:Basigin / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D011467:Prostate / Q000378:metabolism* / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology
D014408:Biomarkers, Tumor; D051926:Basigin