Palladium-catalyzed cross coupling reactions of 4-bromo-6H-1,2-oxazines.
A number of 4-aryl- and 4-alkynyl-substituted 6H-1,2-oxazines 8 and 9 have been prepared in good yields via cross coupling reactions of halogenated precursors 2, which in turn are easily accessible by bromination of 6H-1,2-oxazines 1. Lewis-acid promoted reaction of 1,2-oxazine 9c with 1-hexyne provided alkynyl-substituted pyridine derivative 12 thus demonstrating the potential of this approach for the synthesis of pyridines.
Zimmer
Reinhold
R
Freie Universität Berlin, Institut für Chemie und Biochemie, Takustrasse 3, D-14195 Berlin, Germany. rzimmer@chemie.fu-berlin.de
Schmidt
Elmar
E
Andrä
Michal
M
Duhs
Marcel-Antoine
MA
Linder
Igor
I
Reissig
Hans-Ulrich
HU