Activity-dependent plasticity of spinal locomotion: implications for sensory processing.
The lumbosacral spinal cord of mammals contains the neural circuitry capable of generating full weight-bearing locomotion of the hind limbs without any supraspinal input. One or more interventions, for example, pharmacological, epidural stimulation, and/or locomotor training, however, are necessary to gain access to and modulate the properties of this circuitry and to facilitate recovery of full weight-bearing locomotion after spinal cord injury.
Edgerton
V Reggie
VR
Department of Physiological Science, Brain Research Institute, University of California, Los Angeles, 90095, USA. vre@ucla.edu
Roy
Roland R
RR
D000818:Animals; D002415:Cats; D056228:Feedback, Sensory; D007395:Interneurons / Q000502:physiology; D007858:Learning / Q000502:physiology; D008124:Locomotion / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology; D009415:Nerve Net / Q000502:physiology; D009473:Neuronal Plasticity; D051381:Rats; D013119:Spinal Cord Injuries / Q000534:rehabilitation*; D016474:Weight-Bearing / Q000502:physiology