Odorant-linked ROS-GC subfamily membrane guanylate cyclase transduction system.
This review focuses on the principles of the Ca(2+)-modulated ROS-GC subfamily transduction system linked with the mammalian olfactory transduction field, its historical development, and the present day status on its constitution and operational mechanisms controlling the process of olfactory-transduction. Beginning parts of this article are freely borrowed from the earlier reviews of the authors (Sharma RK, Duda T, Venkataraman V, Koch KW, Curr Topics Biochem Res 6:111-144, 2004; Duda T, Venkataraman V, Sharma RK, Neuronal calcium sensor proteins, pp 91-113, Nova Science Publishers, Inc., 2007).
Sharma
Rameshwar K
RK
Research Divisions of Biochemistry and Molecular Biology, The Unit of Regulatory and Molecular Biology, Salus University, Elkins Park, PA 19027, USA. rsharma@salus.edu
Duda
Teresa
T
D000818:Animals; D006162:Guanylate Cyclase / Q000502:physiology*; D006801:Humans; D009812:Odorants; D009833:Olfactory Pathways; D012374:Rod Cell Outer Segment / Q000201:enzymology; D015398:Signal Transduction
D006162:Guanylate Cyclase