Negative chronotropic effect of proton pump inhibitors on frog-heart preparation.
Proton pump inhibitors (PPIs) have been known to cause bradycardia. We evaluated the effect of three PPIs, i.e. omeprazole, rabeprazole and pantoprazole on the heart rate of frog. The in situ frog heart preparation was set up. Heart rate and amplitude of contraction were studied following administration of different doses of the three PPIs. Statistical analysis was done by using Graphpad statistical software system. After 1 mg of omeprazole and rabeprazole, and 2 mg pantoprazole, the heart rate was similar as compared to baseline (p >0.05). After 2 mg of omeprazole and rabeprazole, and 4 mg pantoprazole, the reduction in heart rate was significant (p <0.05). In addition, pantoprazole caused negative ionotropic effect. The three PPIs showed a dose-dependent negative chronotropic effect in the frog heart prepration.
Gautam
Chander Shekhar
CS
Department of Pharmacology, Government Medical College and Hospital, Chandigarh 160 030, India. csgautam_06@yahoo.co.in
Utreja
Amita
A
Goel
Divya
D
Sandhu
Gurpreet
G
Gogia
Nidhi
N
D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000494:pharmacology; D000818:Animals; D001001:Anura; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D009853:Omeprazole / Q000494:pharmacology; D000077402:Pantoprazole; D054328:Proton Pump Inhibitors / Q000494:pharmacology*; D064750:Rabeprazole
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D054328:Proton Pump Inhibitors; D064750:Rabeprazole; D000077402:Pantoprazole; D009853:Omeprazole