title: [Investigation on the changes of dependent signal on the amplitude of low frequency fluctuations at blood oxygen level in brain after acupuncture Neiguan (PC 6)].
abstract: OBJECTIVE
  To investigate the relationship of the acupoint and its functional location in the brain.
  
  
  METHODS
  Ten healthy participants were examined with the resting state functional magnetic resonance imaging (fM-RI). The scanning includes the resting state 1 (R 1), acupuncture stimulating (AP) Neiguan (PC 6) and the resting state 2 (R 2). All data were analyzed with the amplitude of low frequency fluctuations (ALFF).
  
  
  RESULTS
  1) During the R1, the regions with active signal on the ALFF contained bilateral superior frontal gyrus, medial frontal gyrus and some part of cerebellum (including right declive, culme, tonsil and left uvula), as well as left precuneus, right superiour temporal gyrus. 2) As for AP, the active regions with higher ALFF were bilateral superior frontal gyrus and right cuneus, as well as left middle frontal gyrus, declivis and right semi-lunar lobule. 3) The main difference on ALFF between R1 and AP appeared within bilateral cingulated gyrus and declivis, left lingualgurus, and cuneus, as well as right precuneus, fusiform gyrus, superior frontal gyrus, medial frontal gyrus and superior temporal gyrus, etc.
  
  
  CONCLUSIONS
  After acupuncture stimulating the left Neiguan (PC 6), the active regions on ALFF are detected on bilateral cingulated gyrus, right superior frontal gyrus and medial frontal gyrus, as well as bilateral declivis and left lingual gurus, etc. These regions have the close relationship with the mental disorder and nervous diseases, which might be the possible neural mechanism of acupuncture stimulating Neiguan (PC 6) for treating some of related mental disorder and nervous diseases.
authors: The Third Affiliated Hospital of Henan Colloge of TCM, Zhengzhou, China.
authors: Yong-yan
authors: YY
authors: Han
authors: Hao
authors: H
authors: Yin
authors: You-long
authors: YL
authors: Zhou
authors: Gang
authors: G
authors: Zhang
authors: Yun-hu
authors: YH
authors: Wu
authors: Wei
authors: W
authors: Xing
authors: Fei
authors: F
authors: Sun
authors: Xiang-yu
authors: XY
authors: Jin
authors: Hong-zhou
authors: HZ
authors: Xu
mesh_terms: D015669:Acupuncture Points; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood*; D011859:Radiography; D055815:Young Adult
chemical_list: D010100:Oxygen