The use of viral vectors in introducing genes into agricultural animal species.
The use of viral vectors is a method for introducing foreign genes into various animal species. Vectors based on retro-, adeno-, flavi-, and parvoviruses have been used for research in animal species of agricultural importance, such as chickens, quail, swine, cows, goats, sheep, fish, crustaceans, and mollusks. Viral vectors allow for efficient transgenic integration into host genome or for transient expression of the transgenic construct in somatic tissues. Because of that, viral vectors are important tools for research and potentially other biotechnology applications such as improving animal production qualities and introducing disease resistance, thus improving food quality and safety. Other uses may include generating animal models of human diseases and using animals as bioreactors for production of therapeutic proteins. Each vector type provides a unique set of advantages and limitations, which are in some cases specific to an animal species or a method of introduction. This article discusses viral vector characteristics and potential applications in agriculturally important animal species. It discusses advantages and disadvantages of using viral vectors in genetic engineering of agricultural animals.
Modric
Tomislav
T
Food and Drug Administration, Center for Veterinary Medicine, Rockville, Maryland, USA. tomislav.modric@fda.hhs.gov
Mergia
Ayalew
A
D000818:Animals; D000829:Animals, Domestic; D030801:Animals, Genetically Modified; D004279:DNA, Viral / Q000235:genetics*; D005260:Female; D018014:Gene Transfer Techniques; D005822:Genetic Vectors / Q000235:genetics*; D008297:Male; D012367:RNA, Viral / Q000235:genetics*
D004279:DNA, Viral; D012367:RNA, Viral