Multivariate regression and discreminant calibration models for a novel optical non-invasive blood glucose measurement method named pulse glucometry.
A novel optical non-invasive in vivo blood glucose concentration (BGL) measurement technique, named "Pulse Glucometry", was combined with a kernel method; support vector machines. The total transmitted radiation intensity (I(lambda)) and the cardiac-related pulsatile changes superimposed on I(lambda) in human adult fingertips were measured over the wavelength range from 900 to 1700 nm using a very fast spectrophotometer, obtaining a differential optical density (DeltaOD(lambda)) related to the blood component in the finger tissues. Subsequently, a calibration model using paired data of a family of DeltaOD(lambda)s and the corresponding known BGLs was constructed with support vector machines (SVMs) regression instead of using calibration by a conventional primary component regression (PCR) and partial least squares regression (PLS). Secondly, SVM method was applied to make a nonlinear discriminant calibration model for "Pulse glucometry." Our results show that the regression calibration model based on the support vector machines can provide a good regression for the 101 paired data, in which the BGLs ranged from 89.0-219 mg/dl (4.94-12.2 mmol/l). The resultant regression was evaluated by the Clarke error grid analysis and all data points fell within the clinically acceptable regions (region A: 93%, region B: 7%). The discriminant calibration model using SVMs also provided a good result for classification (accuracy rate 84% in the best case).
Yamakoshi
Yasuhiro
Y
yu.sys Corporation, Kanazawa, Ishikawa, 920-1167, Japan. y@yusys.jp
Ogawa
Mitsuhiro
M
Yamakoshi
Takehiro
T
Tamura
Toshiyo
T
Yamakoshi
Ken-ichi
K
D000465:Algorithms; D001786:Blood Glucose / Q000032:analysis*; D002138:Calibration; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D003936:Diagnosis, Computer-Assisted / Q000379:methods / Q000592:standards; D016002:Discriminant Analysis; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007564:Japan; D015233:Models, Statistical; D015999:Multivariate Analysis; D017156:Photoplethysmography / Q000295:instrumentation* / Q000592:standards*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis / Q000295:instrumentation* / Q000592:standards*
D001786:Blood Glucose