Hyaluronidase in the correction of hyaluronic acid-based fillers: a review and a recommendation for use.
BACKGROUND
Hyaluronic acid (HA) preparations are the most commonly used injectable fillers in esthetic medicine. In contrast to other injectable fillers with hyaluronidase, there is a tool available to reduce unwanted depots of this filler.


OBJECTIVE
The aim of this paper is to give an overview on the present literature and in addition to give some recommendations for use based on the experience of the authors.


METHODS
The overview is based on a literature search.


RESULTS
There is some evidence from two smaller clinical trials that hyaluronidase will effectively decrease injected depots of HA. It has further been shown from case series and case reports that this reduction is clinically relevant. There is less evidence that hyaluronidase is also helpful in adverse reactions to HA-based fillers.


CONCLUSIONS
The reports suggest that the treatment is safe. However, adverse reactions to hyaluronidase such as allergic reactions have been reported. Patient should be informed about that before treatment.
Rzany
Berthold
B
Division of Evidence-based Medicine, Klinik für Dermatologie, Charité Universitätsmedizin, Berlin, Deutschland. berthold.rzany@charite.de
Becker-Wegerich
Petra
P
Bachmann
Frank
F
Erdmann
Ricardo
R
Wollina
Uwe
U
D003357:Cosmetic Techniques; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects*; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic
D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase