Autoimmune pancreatitis associated with various extrapancreatic lesions during a long-term clinical course successfully treated with azathioprine and corticosteroid maintenance therapy.
Autoimmune pancreatitis (AIP) is often associated with systemic extrapancreatic lesions, and the concept of IgG4-related autoimmune disease has been proposed. We report a 62-year-old woman with AIP associated with various extrapancreatic lesions during a long-term clinical course. These extrapancreatic lesions occurred after the withdrawal of steroid therapy. Sclerosing sialadenitis occurred before AIP, whereas autoimmune sensorineural hearing loss, allergic purpura and endocapillary proliferative glomerulonephritis occurred after AIP. However, no relapse was observed for 5 years after the start of maintenance therapy with prednisolone and azathioprine.
Naitoh
Itaru
I
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya.
Nakazawa
Takahiro
T
Ohara
Hirotaka
H
Sano
Hitoshi
H
Ando
Tomoaki
T
Hayashi
Kazuki
K
Tanaka
Hajime
H
Okumura
Fumihiro
F
Miyabe
Katsuyuki
K
Yoshida
Michihiro
M
Takahashi
Satoru
S
Joh
Takashi
T
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D001379:Azathioprine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D006801:Humans; D011695:IgA Vasculitis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D010195:Pancreatitis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D012793:Sialadenitis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D001379:Azathioprine