title: Nutritional status of selenium in Alzheimer's disease patients.
abstract: Studies have shown that various antioxidants are decreased in different age-related degenerative diseases and thus, oxidative stress would have a central role in the pathogenesis of many disorders that involve neuronal degeneration, including Alzheimer's disease (AD). The present study aimed to assess the nutritional status of Se in AD patients and to compare with control subjects with normal cognitive function. The case-control study was carried out on a group of elderly with AD (n 28) and compared with a control group (n 29), both aged between 60 and 89 years. Se intake was evaluated by using a 3-d dietary food record. Se was evaluated in plasma, erythrocytes and nails by using the method of hydride generation atomic absorption spectroscopy. Deficient Se intake was largely observed in the AD group. AD patients showed significantly lower Se levels in plasma, erythrocytes and nails (32.59 microg/l, 43.74 microg/l and 0.302 microg/g) when compared with the control group (50.99 microg/l, 79.16 microg/l and 0.400 microg/g). The results allowed us to suggest that AD has an important relation with Se deficiency.
authors: PRONUT (Program of Applied Human Nutrition)-FSP/FCF/FEA, Faculty of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, Brazil. barbaracardoso@usp.br
authors: Bárbara Rita
authors: BR
authors: Cardoso
authors: Thomas Prates
authors: TP
authors: Ong
authors: Wilson
authors: W
authors: Jacob-Filho
authors: Omar
authors: O
authors: Jaluul
authors: Maria Isabel d'Avila
authors: MI
authors: Freitas
authors: Silvia M Franciscato
authors: SM
authors: Cozzolino
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood*; D016022:Case-Control Studies; D004032:Diet; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D009262:Nails / Q000737:chemistry; D009752:Nutritional Status; D012643:Selenium / Q000008:administration & dosage / Q000032:analysis / Q000097:blood*; D013054:Spectrophotometry, Atomic
chemical_list: D012643:Selenium