title: Thrombopoietin in normal and neoplastic stem cell development.
abstract: It has been known for sometime that thrombopoietin acts on megakaryocytic progenitor cells to stimulate platelet production. It has recently been discovered that it also stimulates the self-renewal and expansion of normal murine and human haematopoietic stem cells (HSCs) by acting on its cognate receptor, the product of the myeloproliferative leukaemia (c-MPL) proto-oncogene. The c-MPL receptor may also play an important role in the development of human myeloproliferative disorders, essential thrombocythemia, myelofibrosis and polycythemia vera, cooperating with the dysregulated Janus kinase JAK2V(617)F.
authors: University of California San Diego Medical Center, San Diego, CA 92103-8811, USA. mal@urmc.rochester.edu
authors: Kenneth
authors: K
authors: Kaushansky
authors: Helen M
authors: HM
authors: Ranney
mesh_terms: D000818:Animals; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D009196:Myeloproliferative Disorders / Q000378:metabolism*; D000090063:Proto-Oncogene Mas; D053628:Receptors, Thrombopoietin / Q000378:metabolism; D013926:Thrombopoietin / Q000378:metabolism*
chemical_list: C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D053628:Receptors, Thrombopoietin; D013926:Thrombopoietin