Nonpathogenesis of simian immunodeficiency virus infection is associated with reduced inflammation and recruitment of plasmacytoid dendritic cells to lymph nodes, not to lack of an interferon type I response, during the acute phase.
Divergent Toll-like receptor 7 (TLR7) and TLR9 signaling has been proposed to distinguish pathogenic from nonpathogenic simian immunodeficiency virus infection in primate models. We demonstrate here that increased expression of type I interferon in pathogenic rhesus macaques compared to nonpathogenic African green monkeys was associated with the recruitment of plasmacytoid dendritic cells in the lymph nodes and the presence of an inflammatory environment early after infection, instead of a difference in the TLR7/9 response.
Campillo-Gimenez
Laure
L
INSERM U841, Faculté Créteil Henri Mondor, 8 Rue du Général Sarrail, 94010 Créteil, France.
Laforge
Mireille
M
Fay
Michèle
M
Brussel
Audrey
A
Cumont
Marie-Christine
MC
Monceaux
Valérie
V
Diop
Ousmane
O
Lévy
Yves
Y
Hurtrel
Bruno
B
Zaunders
John
J
Corbeil
Jacques
J
Elbim
Carole
C
Estaquier
Jérôme
J
D000210:Acute-Phase Reaction / Q000276:immunology / Q000473:pathology; D000818:Animals; D002465:Cell Movement; D002522:Chlorocebus aethiops; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D007370:Interferon Type I / Q000378:metabolism*; D016898:Interferon-alpha / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000473:pathology; D015302:Simian Immunodeficiency Virus / Q000276:immunology* / Q000472:pathogenicity*; D013045:Species Specificity; D051199:Toll-Like Receptor 7 / Q000378:metabolism; D051217:Toll-Like Receptor 9 / Q000378:metabolism; D014774:Virulence / Q000276:immunology
D007370:Interferon Type I; D016898:Interferon-alpha; D016209:Interleukin-8; D051199:Toll-Like Receptor 7; D051217:Toll-Like Receptor 9