title: Immune and virological benefits of 10 years of permanent viral control with antiretroviral therapy.
abstract: The effects of a 10-year control of HIV replication without viral blips with antiretroviral therapy were examined in progressors. CD4 cell counts did not plateau but showed a continuous increase until the 10th year. Ultrasensitive techniques showed very low plasma HIV RNA and cell-associated DNA levels. Robust memory T cell responses to HIV-p24 were higher than in 3-year treated patients and comparable to those of Elite controllers, whereas interferon-gamma-producing HIV-specific T cells were infrequent. Long-term and efficient antiretroviral therapy provides continuous benefits both on the immune system and on the HIV reservoirs.
authors: UPMC Univ Paris 06, INSERM, UMR945, AP-HP, Laboratoire d'Immunologie Cellulaire et Tissulaire, Hôpital Pitié-Salpêtrière, Paris, France.
authors: Amélie
authors: A
authors: Guihot
authors: Roland
authors: R
authors: Tubiana
authors: Guillaume
authors: G
authors: Breton
authors: Anne-Geneviève
authors: AG
authors: Marcelin
authors: Assia
authors: A
authors: Samri
authors: Lambert
authors: L
authors: Assoumou
authors: Emilia
authors: E
authors: Goncalves
authors: François
authors: F
authors: Bricaire
authors: Dominique
authors: D
authors: Costagliola
authors: Vincent
authors: V
authors: Calvez
authors: Christine
authors: C
authors: Rouzioux
authors: Brigitte
authors: B
authors: Autran
authors: Christine
authors: C
authors: Katlama
authors: Guislaine
authors: G
authors: Carcelain
mesh_terms: D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019562:Viral Load; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents