title: Plant-derived alternative treatments for the aging male: facts and myths.
abstract: Soy- or red clover- derived products containing isoflavones have been amply studied in climacteric and postmenopausal women, and confusing contradicting results have been published. The beneficial effects on climacteric complaints, cholesterol and the development of osteoporosis are marginally at best and there are no uterine and mammary safety studies. In males, however, isoflavones may protect the prostate to make them less prone to develop cancer. Cell biological and animal experimental data support this notion. Clinical data about possible beneficial effects on cholesterol or in the bone are largely missing. Hence, soy or red clover products containing the mild estrogenic isoflavones with a slightly higher affinity to the estrogen receptor of the beta in comparison to the alpha subtype may prove to have some beneficial effects in males.
authors: Department of Endocrinology, University Medical Center Goettingen, Germany. ufkendo@med.uni-goettingen.de <ufkendo@med.uni-goettingen.de>
authors: Wolfgang
authors: W
authors: Wuttke
authors: Hubertus
authors: H
authors: Jarry
authors: Dana
authors: D
authors: Seidlova-Wuttke
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology; D008297:Male; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology* / Q000627:therapeutic use; D011467:Prostate / Q000187:drug effects; D011471:Prostatic Neoplasms / Q000517:prevention & control; D013025:Glycine max; D029921:Trifolium
chemical_list: D007529:Isoflavones; D028321:Plant Preparations