Comparison of treatment effect of sodium valproate, propranolol and tricyclic antidepressants in migraine.
This study was conducted to evaluate and compare the efficacy and treatment effect of sodium valprovate with propranolol and tricyclic antidepressive drugs. This piece is a rarandomized clinical trial conducted on 126 migraine patients admitted to brain and nerves clinic in Arak, Iran. Patients were divided in two groups then randomized to study treatments. Data were gathered using a checklist and a complete examination. They were analyzed by Chi square and exact test. In patients with normal and abnormal encephalogram the effectiveness rate of two treatments were 35, 61.9, 95.6 and 28.6%, respectively. This difference between two treatments was statistically significant (p<0.001). But didn't observe significant differences between two sex groups (p>0.05). For treatment and control of the migraine, in patients with normal encephalogram, propranolol with tricyclic antidepressive drugs advised and for abnormal encephalogram sodium valprovate can be the better treatment for management and reduction of headache attacks.
Keyvan
Ghasami
G
Faculty of Medical, Arak University of Medical Sciences, Arak, Iran.
Abolfazl
Mohammad-Beigi
MB
D000927:Anticonvulsants / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy*; D011433:Propranolol / Q000627:therapeutic use*; D016896:Treatment Outcome; D014635:Valproic Acid / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D000927:Anticonvulsants; D000929:Antidepressive Agents, Tricyclic; D014665:Vasodilator Agents; D014635:Valproic Acid; D011433:Propranolol