[Effect of long-term sevoflurane anesthesia on markers of myocardial damage].
OBJECTIVE
To investigate the effect of long-term sevoflurane anesthesia on markers of myocardial damage or toxicity.


METHODS
Forty adult patients scheduled for upper abdominal surgery with general anesthesia for 4 hours or more were randomly divided into Group S and PR (n=20 each). After anesthesia induction, patients of Group S were maintained with only sevoflurane, and patients of Group PR with target-controlled infusion of propofol 2-4 microg/ml and remifentanil 4-8 ng/ml. Anesthesia was titrated to control blood pressure and heart rate change at less than 20 percent of baseline values. Blood samples were draw at pre-induction, 4 h and 24 h post-induction respectively. Serum level of cardiac troponin I, creatine kinase MB and myoglobin were analyzed.


RESULTS
There were no significant changes of troponin I, creatine kinase MB and myoglobin in Group S between pre-induction and 4 h or 24 h post-induction (P > 0.05). And there was also no significant differences as compared with Group PR (P > 0.05).


CONCLUSIONS
At the concentration range of 1.6%-3%, long-term sevoflurane anesthesia does not cause detectable changes of markers of myocardial damage or toxicity.
Zhang
Yun-long
YL
Department of Anesthesiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Guan
Cha-ying
CY
Hu
Shuang-fei
SF
Zhou
Da-chun
DC
D000328:Adult; D000368:Aged; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology*; D000077149:Sevoflurane; D019210:Troponin I / Q000378:metabolism
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D019210:Troponin I; D000077149:Sevoflurane