title: Oxidative status and lipid profile in metabolic syndrome: gender differences.
abstract: BACKGROUND
  Metabolic syndrome is associated with cardiovascular disease and oxidative stress. The aim of this study was to investigate the differences of novel oxidative stress parameters and lipid profiles in men and women with metabolic syndrome.
  
  
  METHODS
  The study population included 88 patients with metabolic syndrome, consisting of 48 postmenauposal women (group I) and 40 men (group II). Premenauposal women were excluded. Plasma levels of total antioxidant status (TAS) and total oxidative status (TOS) were determined by using the Erel automated measurement method, and oxidative stress index (OSI) was calculated. To perform the calculation, the resulting unit of TAS, mmol Trolox equivalent/L, was converted to micromol equivalent/L and the OSI value was calculated as: OSI = [(TOS, micromol/L)/(TAS, mmol Trolox equivalent/L) x 100]. The Student t-test, Mann-Whitney-U test, and chi-squared test were used for statistical analysis; the Pearson correlation coefficient and Spearman rank test were used for correlation analysis. P < or = 0.05 was considered to be statistically significant.
  
  
  RESULTS
  Both women and men had similar properties regarding demographic characteristics and biochemical work up. Group II had significantly lower levels of antioxidant levels of TAS and lower levels of TOS and OSI compared with group I (P = 0.0001, P = 0.0035, and P = 0,0001). Apolipoprotein A (ApoA) levels were significantly higher in group I compared with group II.
  
  
  CONCLUSIONS
  Our findings indicate that women with metabolic syndrome have a better antioxidant status and higher ApoA levels compared with men. Our findings suggest the existence of a higher oxidative stress index in men with metabolic syndrome. Considering the higher risk of atherosclerosis associated with men, these novel oxidative stress parameters may be valuable in the evaluation of patients with metabolic sydrome.
authors: Biochemistry Department, Institute of Cardiology, Istanbul University, Istanbul 34303, Turkey.
authors: Aysem
authors: A
authors: Kaya
authors: Isil
authors: I
authors: Uzunhasan
authors: Murat
authors: M
authors: Baskurt
authors: Alev
authors: A
authors: Ozkan
authors: Esra
authors: E
authors: Ataoglu
authors: Baris
authors: B
authors: Okcun
authors: Zerrin
authors: Z
authors: Yigit
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D001054:Apolipoproteins A / Q000378:metabolism; D001331:Automation; D005260:Female; D006801:Humans; D006973:Hypertension; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D008875:Middle Aged; D008954:Models, Biological; D009765:Obesity; D018384:Oxidative Stress; D017698:Postmenopause; D012737:Sex Factors
chemical_list: D000975:Antioxidants; D001054:Apolipoproteins A