Telomerase gene mutation screening in Chinese patients with aplastic anemia.
To study the incidence of telomerase gene mutations in Chinese patients with acquired bone marrow failure (BMF) and explore its relationship with telomere shortening. Blood samples from 66 patients with aplastic anemia (AA) in northern China were collected and TERC mutation analysis was performed. Two TERC mutations were identified. The incidence of telomerase gene mutations in Chinese people with acquired AA is similar to that of the western people.
Han
Bing
B
Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, No. 1, Shuai Fuyuan, Dongcheng District, Beijing 100730, China. hanbing_li@sina.com.cn
Liu
Bo
B
Cui
Wei
W
Wang
Xuan
X
Lin
Jie
J
Zhao
Yongqiang
Y
D000741:Anemia, Aplastic / Q000201:enzymology / Q000235:genetics*; D001855:Bone Marrow Diseases; D002681:China / Q000453:epidemiology; D004252:DNA Mutational Analysis; D005787:Gene Frequency; D006801:Humans; D015994:Incidence; D009154:Mutation; D019098:Telomerase / Q000235:genetics*; D016615:Telomere / Q000648:ultrastructure
C509186:TERT protein, human; D019098:Telomerase