title: The effect of age on the immune response of horses to vaccination.
abstract: Few studies have investigated immunosenescence in the horse, but it is accepted that the primary and secondary (anamnestic) immune responses may differ between aged and younger horses. The aim of the present study was to determine whether aged horses have a protective immune response post-vaccination. Thirty-four aged healthy horses (> or =20 years) and 29 younger adult horses (4-12 years) of various breeds were vaccinated with commercially produced killed rabies and influenza vaccines. Rabies serum neutralizing antibody titres and equine influenza virus specific antibody subclasses (immunoglobulin IgGa and IgGb) and single radial haemolysis titres were determined. Healthy aged horses mounted a primary immune response to rabies vaccine that was similar to that of younger adult horses. However, aged horses had a significantly reduced anamnestic response to influenza vaccination in comparison with the younger adult horses, even though the pre-vaccination antibody titres of aged horses were higher. Rabies antibody titres in both groups declined significantly by 6 months post-vaccination. Serum concentrations of selenium (Se) and vitamin E were measured to test for potential confounding effects. Significant numbers of horses had suboptimal serum Se concentrations, but Se status had no significant impact on antibody production after vaccination.
authors: Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada. tmuirhead@upei.ca
authors: T L
authors: TL
authors: Muirhead
authors: J T
authors: JT
authors: McClure
authors: J J
authors: JJ
authors: Wichtel
authors: H
authors: H
authors: Stryhn
authors: R J F
authors: RJ
authors: Markham
authors: D
authors: D
authors: McFarlane
authors: D P
authors: DP
authors: Lunn
mesh_terms: D000367:Age Factors; D000375:Aging / Q000276:immunology*; D000818:Animals; D006734:Horse Diseases / Q000276:immunology; D006736:Horses / Q000276:immunology*; D007117:Immunization, Secondary; D007156:Immunologic Memory / Q000276:immunology; D053123:Influenza A Virus, H3N8 Subtype / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000276:immunology; D011819:Rabies Vaccines / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary*
chemical_list: D007252:Influenza Vaccines; D011819:Rabies Vaccines