Synthesis of a new family of 2-ethylidene-gamma-unsaturated delta-amino esters via microwave activated Stille coupling.
A simple approach to a new family of enantiomerically enriched polyunsaturated t-Boc-protected-delta-amino esters is described, via microwave promoted Stille coupling of (Z)-methyl-2-bromobutenoate with stannylated allylamines. The reaction conditions are mild and selective and disclose a simple way to 1-substituted butenoates of defined geometry.
Consiglio
Gabriella Barozzino
GB
Dipartimento di Chimica Organica Ugo Schiff, University of Florence, via della Lastruccia 13, 50019, Sesto Fiorentino, Florence, Italy.
Gaggini
Francesca
F
Mordini
Alessandro
A
Reginato
Gianna
G
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D013237:Stereoisomerism
D000596:Amino Acids; D004952:Esters