Comparison of cytogenetic changes between primary and relapsed patients with borderline tumors of the ovary.
The aim of this work was to compare cytogenetic changes in primary and relapsed borderline tumors of the ovary. We analyzed 11 tumors (6 primary and 5 relapsed) by conventional GTG banding analysis and fluorescence in situ hybridization. The tumors studied were clinical stages I and III. Genomic imbalances were detected in both investigated groups. In the primary tumors group, only simple chromosome changes were detected. There were gains of chromosome 12, 7, and 8. The presence of additional copies of chromosomes 12 and 7 was independent of histologic subtype, whereas trisomy 8 appeared only in serous tumors. In the group of relapsed borderline tumors, besides trisomies 7 and 12, the structural aberrations of chromosomes 1, 6q, 7q, and 10q were revealed. Gains of tested oncogenes (CCND1 and MYC) have been demonstrated in both groups of investigated tumors. Gains of CCNC1 and MYC genes could be of prognostic value in borderline tumors, but this assumption requires further research.
Grygalewicz
Beata
B
Cytogenetic Laboratory, Maria Sklodowska-Curie Memorial Cancer Centre and Institute, ul. Roentgena 5, 02-781 Warsaw, Poland. bgrygal@coi.waw.pl
Sobiczewski
Piotr
P
Krawczyk
Paulina
P
Woroniecka
Renata
R
Rygier
Jolanta
J
Pastwińska
Anna
A
Bidziński
Mariusz
M
Pieńkowska-Grela
Barbara
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002877:Chromosomes, Human; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D012008:Recurrence; D055815:Young Adult