title: Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus.
abstract: Based on the promising drug resistance profile and potent anti-HIV activity of beta-d-3'-azido-2',3'-dideoxyguanosine, a series of purine modified nucleosides were synthesized by a chemical transglycosylation reaction and evaluated for their antiviral activity, cytotoxicity, and intracellular metabolism. Among the synthesized compounds, several show potent and selective anti-HIV activity in primary lymphocytes.
authors: Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Veterans Affairs Medical Center, Atlanta, GA 30033, USA.
authors: Hong-Wang
authors: HW
authors: Zhang
authors: Steven J
authors: SJ
authors: Coats
authors: Lavanya
authors: L
authors: Bondada
authors: Franck
authors: F
authors: Amblard
authors: Mervi
authors: M
authors: Detorio
authors: Ghazia
authors: G
authors: Asif
authors: Emilie
authors: E
authors: Fromentin
authors: Sarah
authors: S
authors: Solomon
authors: Aleksandr
authors: A
authors: Obikhod
authors: Tony
authors: T
authors: Whitaker
authors: Nicolas
authors: N
authors: Sluis-Cremer
authors: John W
authors: JW
authors: Mellors
authors: Raymond F
authors: RF
authors: Schinazi
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D006031:Glycosylation; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; C051073:3'-azido-2',3'-dideoxyguanosine; D054303:HIV Reverse Transcriptase