title: [Hepcidin and Plasmodium falciparum malaria in anemic school children in Mali].
abstract: Hepcidin is a peptide produced by hepatocytes and detectable in blood and urine. Urinary hepcidin excretion appeared to be significantly increasing in humans with acute and chronic infections or inflammatory diseases. However, the effects of common tropical parasitic infections on hepcidin have not been sufficiently examined. We carried out a study in school children from Mali living in a neighborhood where Plasmodium falciparum malaria and Schistosoma haematobium infections are prevalent. Anemia (hemoglobin < 120 g/l) prevalence was very high among these children (68%); 24% had iron deficiency anemia. The prevalence of infections was also high (65% had at least one infection and 41% had C-reactive protein (CRP) levels > 10 mg/L). S. haematobium was diagnosed in 64%. We assessed first morning urine hepcidin excretion in a sub-sample of 15 children with either S. haematobium, P. falciparum malaria or none; 14 of these 15 children were included in the analyses. Children with P. falciparum malaria excreted significantly higher levels of hepcidin than those with S. haematobium (chi2 = 3.86; p = 0.05) or without any infection (chi2 = 5.95; p = 0.01). Urinary hepcidin correlated significantly with CRP (Spearman's r = 0.59; p = 0.001) and serum ferritin (Spearman's r = 0.73; p = 0.003). Our study confirms the still limited evidence of an association between human malaria and increased urinary hepcidin and points out the need for further studies to define the contribution of hepcidin to anemia associated with this disease.
authors: UNICEF, 73 Lodi Estate, New Delhi 110-003, India. mayoya@unicef.org
authors: M A
authors: MA
authors: Ayoya
authors: R J
authors: RJ
authors: Stoltzfus
authors: G M
authors: GM
authors: Spiekermann-Brouwer
authors: E
authors: E
authors: Nemeth
authors: A K
authors: AK
authors: Traoré
authors: T
authors: T
authors: Ganz
authors: C
authors: C
authors: Garza
mesh_terms: D000740:Anemia / Q000453:epidemiology / Q000209:etiology* / Q000652:urine; D018798:Anemia, Iron-Deficiency / Q000453:epidemiology / Q000209:etiology / Q000652:urine; D023181:Antimicrobial Cationic Peptides / Q000502:physiology / Q000652:urine*; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D003430:Cross-Sectional Studies; D019353:Endemic Diseases; D005260:Female; D064451:Hepcidins; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology; D019266:Iron, Dietary / Q000493:pharmacokinetics; D008099:Liver / Q000378:metabolism / Q000469:parasitology; D016778:Malaria, Falciparum / Q000097:blood / Q000150:complications* / Q000453:epidemiology / Q000652:urine; D008297:Male; D008302:Mali / Q000453:epidemiology; D008954:Models, Biological; D015995:Prevalence; D012553:Schistosomiasis haematobia / Q000097:blood / Q000150:complications / Q000453:epidemiology / Q000652:urine
chemical_list: D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D019266:Iron, Dietary; D002097:C-Reactive Protein