Scopolamine-induced convulsions in fasted mice after food intake: evaluation of the sedative effect in the suppression of convulsions.
Food intake triggers convulsions in fasted mice and rats treated with antimuscarinic drugs, scopolamine or atropine. Most of the drugs produced anticonvulsant efficacy in these convulsions have sedative effects. Thus, the present study was performed to evaluate the contribution of sedation in the suppression of convulsions by using sedative drugs chlorpromazine, morphine, amitriptyline and diphenhydramine. Mice fasted for 24h and treated with 3mg/kg scopolamine developed convulsions soon after refeeding. Treatment of chlorpromazine and morphine during food deprivation did not provide a preventive effect in the development of convulsions observed after food intake in fasted animals. Pretreatment of amitriptyline, but not diphenhydramine, before scopolamine treatment suppressed the incidence of convulsions. Present results could not clearly demonstrate the role played by sedative effect in suppression of convulsions in fasted animals.
Enginar
Nurhan
N
Department of Pharmacology and Clinical Pharmacology, Istanbul Faculty of Medicine, 34390, Capa, Istanbul, Turkey. engnur@istanbul.edu.tr
Nurten
Asiye
A
Karamürsel
Yeşim
Y
Zengin
Asli
A
Baran
Elif
E
D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D001835:Body Weight / Q000502:physiology; D002746:Chlorpromazine / Q000494:pharmacology; D004155:Diphenhydramine / Q000494:pharmacology; D004435:Eating / Q000187:drug effects*; D005508:Food Deprivation; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D012601:Scopolamine; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy*
D006993:Hypnotics and Sedatives; D000639:Amitriptyline; D009020:Morphine; D004155:Diphenhydramine; D012601:Scopolamine; D002746:Chlorpromazine