[Study on the swelling and release properties of pectinate gel beads crosslinked with different metal ions].
This study was aimed to reveal how the swelling properties and release behavior of a model drug from pectin gel beads were influenced by its crosslinking with different metal ions. Coomassie Brilliant Blue G-250 was chosen as the model drug. Pectinate beads were prepared by the dropping method and crosslinked with Ca2+, Fe3+, Zn2+, Ba2+, respectively. The release behavior and swelling properties were investigated. The results showed that there were significant differences between the pectinate beads that were crosslinked with different ions. Pectinate gel beads, as a potential cell microencapsulation and drug vehicle, could be acquired for different release profile by crosslinking with different ions.
Zhang
Liangke
L
Chongqing Key Laboratory of Biochemistry & Molecular Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China. zlkdyx@sina.com
Yuan
Pei
P
Tian
Rui
R
Ling
Xu
X
Yu
Ruijie
R
D002118:Calcium / Q000737:chemistry / Q000494:pharmacology; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry / Q000494:pharmacology; D005782:Gels / Q000737:chemistry*; D008670:Metals / Q000737:chemistry* / Q000494:pharmacology; D008863:Microspheres; D010368:Pectins / Q000737:chemistry*
D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005290:Ferric Compounds; D005782:Gels; D008670:Metals; D010368:Pectins; D002118:Calcium