Hyperinsulinism and diabetes: genetic dissection of beta cell metabolism-excitation coupling in mice.
The role of metabolism-excitation coupling in insulin secretion has long been apparent, but in recent years, in parallel with studies of human hyperinsulinism and diabetes, genetic manipulation of proteins involved in glucose transport, metabolism, and excitability in mice has brought the central importance of this pathway into sharp relief. We focus on these animal studies and how they provide important insights into not only metabolic and electrical regulation of insulin secretion, but also downstream consequences of alterations in this pathway and the etiology and treatment of insulin-secretion diseases in humans.
Remedi
Maria Sara
MS
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA. mremedi@wustl.edu
Nichols
Colin G
CG
D000818:Animals; D003920:Diabetes Mellitus / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D005947:Glucose / Q000235:genetics / Q000378:metabolism; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D007328:Insulin / Q000235:genetics / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism; D051379:Mice; D015398:Signal Transduction
D007328:Insulin; D007473:Ion Channels; D005947:Glucose