title: Replication of a genome-wide association study of panic disorder in a Japanese population.
abstract: Panic disorder (PD) is an anxiety disorder characterized by recurrent and unexpected panic attacks, subsequent worry and phobic avoidance. Although a number of association and linkage studies have been conducted, no gene has been identified as a susceptibility locus. We previously conducted a genome-wide association analysis of PD in 200 Japanese patients and the same number of controls, using a 500 K single nucleotide polymorphisms (SNPs) chip. In this study, we report a replication analysis of PD using the DigTag2 assay. The second stage sample consisted of 558 Japanese patients and 566 controls. Thirty-two markers were tested in a replication sample. As a result, no significant association was found after correction for multiple testing. However, the difference was observed at the nominal allele P-value <0.05 for two SNPs (rs6733840 and rs132617). We also conducted haplotype analyses of SNPs in the APOL3 and CLU genes. Our results failed to show any significant association with PD in these genes. Further studies on these variants with a larger sample size may be worth testing to confirm the results.
authors: Department of Neuropsychiatry, the University of Tokyo, Japan. totowa-psy@umin.ac.jp
authors: Takeshi
authors: T
authors: Otowa
authors: Hisashi
authors: H
authors: Tanii
authors: Nagisa
authors: N
authors: Sugaya
authors: Eiji
authors: E
authors: Yoshida
authors: Ken
authors: K
authors: Inoue
authors: Shin
authors: S
authors: Yasuda
authors: Takafumi
authors: T
authors: Shimada
authors: Yoshiya
authors: Y
authors: Kawamura
authors: Mamoru
authors: M
authors: Tochigi
authors: Takanobu
authors: T
authors: Minato
authors: Tadashi
authors: T
authors: Umekage
authors: Taku
authors: T
authors: Miyagawa
authors: Nao
authors: N
authors: Nishida
authors: Katsushi
authors: K
authors: Tokunaga
authors: Yuji
authors: Y
authors: Okazaki
authors: Hisanobu
authors: H
authors: Kaiya
authors: Tsukasa
authors: T
authors: Sasaki
mesh_terms: D001053:Apolipoproteins / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D051152:Clusterin / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007564:Japan; D008297:Male; D016584:Panic Disorder / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D001053:Apolipoproteins; C495242:CLU protein, human; D051152:Clusterin