title: Kinematic improvement following Botulinum Toxin-A injection in upper-limb spasticity due to stroke.
abstract: Background Focal spasticity is a significant motor disorder following stroke, and Botulinum Toxin Type-A (BoNT-A) is a useful treatment for this. The authors evaluated kinematic modifications induced by spasticity, and whether or not there is any improvement following injection of BoNT-A. Methods Eight patients with stroke with upper-limb spasticity, showing a flexor pattern, were evaluated using kinematics before and after focal treatment with BoNT-A. A group of sex- and age-matched normal volunteers acted as a control group. Results Repeated-measures ANOVA showed that patients with stroke performed more slowly than the control group. Following treatment with BoNT-A, there was a significant improvement in kinematics in patients with stroke, while in the control group, performance remained unchanged. Conclusions Focal treatment of spasticity with BoNT-A leads to an adaptive change in the upper limb of patients with spastic stroke.
authors: Neurorehabilitation Section and Spasticity Clinic, Neurology Department, Institute for Neurological Research, FLENI, Montaneses 2325, Buenos Aires C1428AQK, Argentina. efridman@fleni.org.ar
authors: Esteban A
authors: EA
authors: Fridman
authors: Marcos
authors: M
authors: Crespo
authors: Santiago
authors: S
authors: Gomez Argüello
authors: Lorena
authors: L
authors: Degue
authors: Mirta
authors: M
authors: Villarreal
authors: Stephan
authors: S
authors: Bohlhalter
authors: Lewis
authors: L
authors: Wheaton
authors: Mark
authors: M
authors: Hallett
mesh_terms: D001696:Biomechanical Phenomena / Q000187:drug effects* / Q000502:physiology*; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D013035:Spasm / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D020521:Stroke / Q000150:complications*; D034941:Upper Extremity / Q000503:physiopathology*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A