title: Advantage of next-generation frequency-domain optical coherence tomography compared with conventional time-domain system in the assessment of coronary lesion.
abstract: BACKGROUND
  Intracoronary optical coherence tomography (OCT) is a high-resolution imaging modality used for evaluation of coronary lesion morphology. However, current time-domain OCT (TD-OCT) have a number of limitations with regard to both procedural usage and safety in the clinical setting. The next-generation frequency-domain OCT (FD-OCT), which has a much faster frame rate and pullback speed than TD-OCT, is expected to overcome these limitations. The aim of this study was to evaluate the feasibility and usability of next generation FD-OCT in the assessment of coronary lesions.
  
  
  METHODS
  A comparison study was performed between FD-OCT and TD-OCT from the aspect of usability (set-up time), qualitatively (rate of clear image segment), and safety (adverse event) in 14 ischemic heart disease patients with 20 previously implanted coronary stents.
  
  
  RESULTS
  The mean time of the OCT procedure in this study from setup to completion of image acquisition was 3.2 +/- 0.8 min for FD-OCT and 11.2 +/- 2.5 min for TD-OCT (P < 0.01). In qualitative image assessment, FD-OCT has the potential to yield a higher rate of clear image segments (CIS) than TD-OCT (99.4% vs. 80.8%, respectively; P < 0.01). In addition to these improved characteristics, there were no ischemic ECG changes or arrhythmia associated with FD-OCT.
  
  
  CONCLUSIONS
  The next-generation intracoronary FD-OCT has better performance in the clinical setting and the potential to overcome several limitations of conventional TD-OCT systems.
authors: Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan.
authors: Shigeho
authors: S
authors: Takarada
authors: Toshio
authors: T
authors: Imanishi
authors: Yong
authors: Y
authors: Liu
authors: Hideyuki
authors: H
authors: Ikejima
authors: Hiroto
authors: H
authors: Tsujioka
authors: Akio
authors: A
authors: Kuroi
authors: Kohei
authors: K
authors: Ishibashi
authors: Kenichi
authors: K
authors: Komukai
authors: Takashi
authors: T
authors: Tanimoto
authors: Yasushi
authors: Y
authors: Ino
authors: Hironori
authors: H
authors: Kitabata
authors: Takashi
authors: T
authors: Kubo
authors: Nobuo
authors: N
authors: Nakamura
authors: Kumiko
authors: K
authors: Hirata
authors: Atsushi
authors: A
authors: Tanaka
authors: Masato
authors: M
authors: Mizukoshi
authors: Takashi
authors: T
authors: Akasaka
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D018570:Risk Assessment; D015607:Stents; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome