title: Intraluminal versus infiltrating gallbladder carcinoma: clinical presentation, ultrasound and computed tomography.
abstract: OBJECTIVE
  To compare clinical presentation and ultrasound (US) and computed tomography (CT) sensitivity between intraluminal and infiltrating gallbladder carcinoma (GBCA).
  
  
  METHODS
  This retrospective study evaluated 65 cases of GBCA that were categorized morphologically into the intraluminal-GBCA (n = 37) and infiltrating-GBCA (n = 28) groups. The clinical and laboratory findings, presence of gallstones, gallbladder size, T-staging, nodal status, sensitivity of preoperative US and CT studies, and outcome were compared between the two groups.
  
  
  RESULTS
  There were no significant differences between the two groups with respect to female predominance, presence of abdominal pain, serum aminotransferases level, T2-T4 staging, and regional metastatic nodes. Compared with the patients with intraluminal-GBCA, those with infiltrating-GBCA were significantly older (65.49 +/- 1.51 years vs 73.07 +/- 1.90 years), had a higher frequency of jaundice (3/37 patients vs 13/28 patients) and fever (3/37 patients vs 10/28 patients), higher alkaline phosphatase (119.36 +/- 87.80 IU/L vs 220.68 +/- 164.84 IU/L) and total bilirubin (1.74 +/- 2.87 mg/L vs 3.50 +/- 3.51 mg/L) levels, higher frequency of gallstones (12/37 patients vs 22/28 patients), smaller gallbladder size (length, 7.47 +/- 1.70 cm vs 6.47 +/- 1.83 cm; width, 4.21 +/- 1.43 cm vs 2.67 +/- 0.93 cm), and greater proportion of patients with < 12 mo survival (16/37 patients vs 18/28 patients). The sensitivity for diagnosing intraluminal-GBCA with and without gallstones was 63.6% and 91.3% by US, and 80% and 100% by CT, respectively. The sensitivity for diagnosing infiltrating-GBCA with and without gallstones was 12.5% and 25% by US, and 71.4% and 75% by CT, respectively.
  
  
  CONCLUSIONS
  In elderly women exhibiting small gallbladder and gallstones on US, especially those with jaundice, fever, high alkaline phosphatase and bilirubin levels, CT may reveal concurrent infiltrating-GBCA.
authors: Department of Radiology, Chang Gung University, College of Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Niao-Sung Hsiang, Kaohsiung Hsien, Taiwan, China.
authors: Tze-Yu
authors: TY
authors: Lee
authors: Sheung-Fat
authors: SF
authors: Ko
authors: Chung-Cheng
authors: CC
authors: Huang
authors: Shu-Hang
authors: SH
authors: Ng
authors: Jiun-Lung
authors: JL
authors: Liang
authors: Hsuan-Ying
authors: HY
authors: Huang
authors: Min-Chi
authors: MC
authors: Chen
authors: Shyr-Ming
authors: SM
authors: Sheen-Chen
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005334:Fever / Q000209:etiology; D005704:Gallbladder / Q000473:pathology; D005706:Gallbladder Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*; D042882:Gallstones / Q000209:etiology / Q000473:pathology; D006801:Humans; D007565:Jaundice / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography