title: Patient-specific wall stress analysis in cerebral aneurysms using inverse shell model.
abstract: Stress analyses of patient-specific vascular structures commonly assume that the reconstructed in vivo configuration is stress free although it is in a pre-deformed state. We submit that this assumption can be obviated using an inverse approach, thus increasing accuracy of stress estimates. In this paper, we introduce an inverse approach of stress analysis for cerebral aneurysms modeled as nonlinear thin shell structures, and demonstrate the method using a patient-specific aneurysm. A lesion surface derived from medical images, which corresponds to the deformed configuration under the arterial pressure, is taken as the input. The wall stress in the given deformed configuration, together with the unstressed initial configuration, are predicted by solving the equilibrium equations as opposed to traditional approach where the deformed geometry is assumed stress free. This inverse approach also possesses a unique advantage, that is, for some lesions it enables us to predict the wall stress without accurate knowledge of the wall elastic property. In this study, we also investigate the sensitivity of the wall stress to material parameters. It is found that the in-plane component of the wall stress is indeed insensitive to the material model.
authors: Department of Mechanical and Industrial Engineering, Center for Computer Aided Design, The University of Iowa, Iowa City, IA 52242, USA.
authors: Xianlian
authors: X
authors: Zhou
authors: Madhavan L
authors: ML
authors: Raghavan
authors: Robert E
authors: RE
authors: Harbaugh
authors: Jia
authors: J
authors: Lu
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D002536:Cerebral Arteries / Q000503:physiopathology*; D003198:Computer Simulation; D055119:Elastic Modulus; D006801:Humans; D002532:Intracranial Aneurysm / Q000503:physiopathology*; D008955:Models, Cardiovascular; D033081:Shear Strength; D013314:Stress, Mechanical