title: Hypophysectomy for a dog with coexisting Cushing's disease and diabetes mellitus.
abstract: An 11-year-old male mixed breed dog diagnosed with Cushing's disease and diabetes mellitus was treated by hypophysectomy. After surgery, the hypercortisolemia disappeared and the diabetes status improved. The insulin requirement to control hyperglycemia gradually decreased. At 12 weeks after surgery, there was no requirement for insulin and we suspected the diabetes was completely resolved. In the present case, diabetes mellitus seems to be secondary to Cushing's disease. In conclusion, this mixed breed dog with coexisting Cushing's disease and diabetes mellitus is the first case showing the effectiveness of hypophysectomy to treat diabetes mellitus secondary to Cushing's disease in dogs.
authors: Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan. hiro-ish@pp.iij4u.or.jp
authors: Hirokazu
authors: H
authors: Ishino
authors: Yasushi
authors: Y
authors: Hara
authors: Takahiro
authors: T
authors: Teshima
authors: Shigeki
authors: S
authors: Tanaka
authors: Susumu
authors: S
authors: Takekoshi
authors: Yoshinori
authors: Y
authors: Nezu
authors: Yasuji
authors: Y
authors: Harada
authors: Takuya
authors: T
authors: Yogo
authors: Toshinori
authors: T
authors: Sako
authors: Hidekazu
authors: H
authors: Koyama
authors: Akira
authors: A
authors: Teramoto
authors: Robert Y
authors: RY
authors: Osamura
authors: Masahiro
authors: M
authors: Tagawa
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors; D000324:Adrenocorticotropic Hormone / Q000276:immunology; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D048909:Diabetes Complications / Q000601:surgery / Q000662:veterinary*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000662:veterinary*; D013196:Dihydrotestosterone / Q000031:analogs & derivatives / Q000627:therapeutic use; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007016:Hypophysectomy / Q000379:methods / Q000662:veterinary*; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D047748:Pituitary ACTH Hypersecretion / Q000150:complications / Q000601:surgery / Q000662:veterinary*; D010902:Pituitary Gland / Q000473:pathology
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D013196:Dihydrotestosterone; D000324:Adrenocorticotropic Hormone; D015096:3-Hydroxysteroid Dehydrogenases; C009954:trilostane