title: Prediction of post-operative necrosis after mastectomy: a pilot study utilizing optical diffusion imaging spectroscopy.
abstract: BACKGROUND
  Flap necrosis and epidermolysis occurs in 18-30% of all mastectomies. Complications may be prevented by intra-operative detection of ischemia. Currently, no technique enables quantitative valuation of mastectomy skin perfusion. Optical Diffusion Imaging Spectroscopy (ViOptix T.Ox Tissue Oximeter) measures the ratio of oxyhemoglobin to deoxyhemoglobin over a 1 x 1 cm area to obtain a non-invasive measurement of perfusion (StO2).
  
  
  METHODS
  This study evaluates the ability of ViOptix T.Ox Tissue Oximeter to predict mastectomy flap necrosis. StO2 measurements were taken at five points before and at completion of dissection in 10 patients. Data collected included: demographics, tumor size, flap length/thickness, co-morbidities, procedure length, and wound complications.
  
  
  RESULTS
  One patient experienced mastectomy skin flap necrosis. Five patients underwent immediate reconstruction, including the patient with necrosis. Statistically significant factors contributing to necrosis included reduction in medial flap StO2 (p = 0.0189), reduction in inferior flap StO2 (p = 0.003), and flap length (p = 0.009).
  
  
  CONCLUSIONS
  StO2 reductions may be utilized to identify impaired perfusion in mastectomy skin flaps.
authors: Department of Surgery, Division of Surgical Oncology, University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9155, USA. Roshni.Rao@utsouthwestern.edu
authors: Roshni
authors: R
authors: Rao
authors: Michel
authors: M
authors: Saint-Cyr
authors: Aye Moe Thu
authors: AM
authors: Ma
authors: Monet
authors: M
authors: Bowling
authors: Daniel A
authors: DA
authors: Hatef
authors: Valerie
authors: V
authors: Andrews
authors: Xian-Jin
authors: XJ
authors: Xie
authors: Theresa
authors: T
authors: Zogakis
authors: Rod
authors: R
authors: Rohrich
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D009336:Necrosis; D055096:Optical Devices; D010100:Oxygen / Q000378:metabolism; D010865:Pilot Projects; D011182:Postoperative Care; D011379:Prognosis; D012867:Skin / Q000473:pathology*; D013524:Surgical Flaps / Q000473:pathology*; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D010100:Oxygen