title: Total synthesis and biological evaluation of methylgerambullone.
abstract: First total synthesis of methylgerambullone (MGB, 1) isolated from Glycosmis angustifolia was completed via a convergent route. The effect of MGB on the contractile responses of the isolated guinea-pig ileum induced by acetylcholine was investigated. As a result, it showed a potent relaxation rate (78.66+/-4.30% at 100mg/L) in a concentration-dependent manner on longitudinal smooth muscle contraction of isolated guinea-pig ileum induced by 1microM acetylcholine.
authors: Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors: Jong Taik
authors: JT
authors: Moon
authors: Sung Hoon
authors: SH
authors: Ha
authors: So Hyung
authors: SH
authors: Lee
authors: Tae Hui
authors: TH
authors: Kwon
authors: Chun Rim
authors: CR
authors: Oh
authors: Young Deuk
authors: YD
authors: Kim
authors: Jungahn
authors: J
authors: Kim
authors: Dong Joon
authors: DJ
authors: Choo
authors: Jae Yeol
authors: JY
authors: Lee
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000178:Acrylamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006168:Guinea Pigs; D007085:Ilium / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D027821:Rutaceae / Q000737:chemistry; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000178:Acrylamides; D001688:Biological Products; D013450:Sulfones; C549129:methylgerambullone; D000109:Acetylcholine