Calprotectin, RAGE and TNF-α in hypertensive disorders in pregnancy: expression and significance.
OBJECTIVE
To investigate the expression of calprotectin, the receptor of advanced glycation end products (RAGE) and tumor necrosis factor-α (TNF-α) in hypertensive disorders in pregnancy as well as the significance of their expression.


METHODS
The research assessed levels of plasma calprotectin and TNF-α using the enzyme-linked immunosorbent assay, and expression of calprotectin, RAGE and TNF-α in placenta tissues using the immunohistochemistry streptavidin-peroxidase (S-P) method in 60 women with hypertensive disorders in pregnancy and 32 women with normal pregnancy (as the controls).


RESULTS
Compared with the control group, the levels of calprotectin, RAGE and TNF-α were elevated in plasma or placenta tissues in the group with hypertensive disorders in pregnancy, and were positively correlated with severity of hypertensive disorders in pregnancy. The levels of calprotectin were consistent with TNF-α in plasma and placenta tissues in the group with hypertensive disorders in pregnancy.


CONCLUSIONS
Changes in calprotectin, RAGE and TNF-α levels in maternal serum and placental tissue correlate to the pathogenesis and disease progression of hypertensive disorders in pregnancy.
Feng
Chong
C
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, 110004, Shenyang, Liaoning, China.
Tao
Yongjian
Y
Shang
Tao
T
Yu
Miao
M
D000328:Adult; D005260:Female; D017127:Glycation End Products, Advanced; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000378:metabolism*; D007150:Immunohistochemistry; D039841:Leukocyte L1 Antigen Complex / Q000097:blood / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000378:metabolism*
D017127:Glycation End Products, Advanced; D039841:Leukocyte L1 Antigen Complex; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D014409:Tumor Necrosis Factor-alpha