[Effect of felodipine on the expression of NF-kappaB in rat model of atherosclerosis].
OBJECTIVE
To investigate the possible mechanism of felodipine on experimental atheroselerosis formation in rats.


METHODS
The rat model of atherosclerosis was established by the methods of intraperitoneal injection of Vitamin D3 and high-fat diet. Thirty male SD rats were randomly divided into normal group, atherosclerosis model group and felodipine treating group. At the end of 6 weeks, the expression of NF-kappaB (nuclear transcription fator-kappaB) in endothelial cells and smooth muscle cells of aorta were determined.


RESULTS
The positive rates of NF-kappaB in both atherosclerosis model group and felodipine treating group (46.59+/-5.68, 20.47+/-1.97) were higher than that of normal group (4.38+/-1.07, P<0.01). The expression of NF-kappaB in atherosclerosis model group was higher than that of felodipine treating group (P<0.01).


CONCLUSIONS
The mechanism of felodipine in relieving atheroselerosis may correlate with the inhibition of NF-kappaBp65 activation.
Du
Xiao-Dong
XD
Emergency Department, West China Hospital, Sichuan University, Chengdu, China.
Zhang
Shu
S
Cao
Yu
Y
Nie
Hu
H
D000818:Animals; D001011:Aorta / Q000378:metabolism; D050197:Atherosclerosis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D004041:Dietary Fats; D015736:Felodipine / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014807:Vitamin D
D002121:Calcium Channel Blockers; D004041:Dietary Fats; D016328:NF-kappa B; D014807:Vitamin D; D015736:Felodipine