A first-generation haplotype map of maize.
Maize is an important crop species of high genetic diversity. We identified and genotyped several million sequence polymorphisms among 27 diverse maize inbred lines and discovered that the genome was characterized by highly divergent haplotypes and showed 10- to 30-fold variation in recombination rates. Most chromosomes have pericentromeric regions with highly suppressed recombination that appear to have influenced the effectiveness of selection during maize inbred development and may be a major component of heterosis. We found hundreds of selective sweeps and highly differentiated regions that probably contain loci that are key to geographic adaptation. This survey of genetic diversity provides a foundation for uniting breeding efforts across the world and for dissecting complex traits through genome-wide association studies.
Gore
Michael A
MA
United States Department of Agriculture-Agriculture Research Service (USDA-ARS), USA.
Chia
Jer-Ming
JM
Elshire
Robert J
RJ
Sun
Qi
Q
Ersoz
Elhan S
ES
Hurwitz
Bonnie L
BL
Peiffer
Jason A
JA
McMullen
Michael D
MD
Grills
George S
GS
Ross-Ibarra
Jeffrey
J
Ware
Doreen H
DH
Buckler
Edward S
ES
D001947:Breeding; D002874:Chromosome Mapping; D032461:Chromosomes, Plant / Q000235:genetics; D019143:Evolution, Molecular; D014644:Genetic Variation; D018745:Genome, Plant; D055106:Genome-Wide Association Study; D006239:Haplotypes; D006579:Heterozygote; D006823:Hybrid Vigor; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA; D045868:Sorghum / Q000235:genetics; D003313:Zea mays / Q000235:genetics*