Replication of a genome-wide association study of panic disorder in a Japanese population.
Panic disorder (PD) is an anxiety disorder characterized by recurrent and unexpected panic attacks, subsequent worry and phobic avoidance. Although a number of association and linkage studies have been conducted, no gene has been identified as a susceptibility locus. We previously conducted a genome-wide association analysis of PD in 200 Japanese patients and the same number of controls, using a 500 K single nucleotide polymorphisms (SNPs) chip. In this study, we report a replication analysis of PD using the DigTag2 assay. The second stage sample consisted of 558 Japanese patients and 566 controls. Thirty-two markers were tested in a replication sample. As a result, no significant association was found after correction for multiple testing. However, the difference was observed at the nominal allele P-value <0.05 for two SNPs (rs6733840 and rs132617). We also conducted haplotype analyses of SNPs in the APOL3 and CLU genes. Our results failed to show any significant association with PD in these genes. Further studies on these variants with a larger sample size may be worth testing to confirm the results.
Otowa
Takeshi
T
Department of Neuropsychiatry, the University of Tokyo, Japan. totowa-psy@umin.ac.jp
Tanii
Hisashi
H
Sugaya
Nagisa
N
Yoshida
Eiji
E
Inoue
Ken
K
Yasuda
Shin
S
Shimada
Takafumi
T
Kawamura
Yoshiya
Y
Tochigi
Mamoru
M
Minato
Takanobu
T
Umekage
Tadashi
T
Miyagawa
Taku
T
Nishida
Nao
N
Tokunaga
Katsushi
K
Okazaki
Yuji
Y
Kaiya
Hisanobu
H
Sasaki
Tsukasa
T
D001053:Apolipoproteins / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D051152:Clusterin / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007564:Japan; D008297:Male; D016584:Panic Disorder / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
D001053:Apolipoproteins; C495242:CLU protein, human; D051152:Clusterin