Interleukin-1 gene -511 CT polymorphism and the risk of Alzheimer's disease in a Polish population.
Interleukin-1 is a potent proinflammatory cytokine involved in the pathophysiology of Alzheimer's disease (AD). We genotyped IL-1beta (-511 C/T) and the apolipoprotein E (APOE) common polymorphisms in a large case-controlled study in a Polish population. We included 332 patients with late-onset AD and 220 controls without any neurological deficit, cognitive complaints and history of neurological diseases, aged > or = 65 years. The distribution of the IL-1beta (-511 C/T) genotypes was similar to that in the controls (AD: C/C = 45.8%, C/T = 44.6%, T/T = 9.6% vs. controls: C/C = 53.9%, C/T = 38.3%, T/T = 7.3%, p > 0.05). Our study confirms previous reports that APOE epsilon4 is strongly related to the risk of AD (odds ratio = 6.60, 95% confidence interval 4.19-10.41). APOE status did not affect the distribution of the studied IL-1beta polymorphism. The IL-1beta (-511 C/T) polymorphism is not a risk factor for late-onset AD in a Polish population.
Klimkowicz-Mrowiec
A
A
Department of Neurology, University Hospital, Cracow, Poland. Aleksandra.Klimkowicz@mp.pl
Marona
M
M
Wołkow
P
P
Maruszak
A
A
Styczynska
M
M
Barcikowska
M
M
Zekanowski
C
C
Szczudlik
A
A
Slowik
A
A
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic; D012307:Risk Factors
D053327:Apolipoprotein E4; D053583:Interleukin-1beta