Ubiquitous RNA-dependent RNA polymerase and gene silencing.
The discovery of a novel RNA-dependent RNA polymerase activity with a eukaryote-wide distribution raises new questions about the roles and mechanisms of gene silencing by small RNAs.
Birchler
James A
JA
Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA. BirchlerJ@Missouri.edu.
D000818:Animals; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D004330:Drosophila; D020868:Gene Silencing; D006801:Humans; D008957:Models, Genetic; D012319:RNA Polymerase II / Q000235:genetics; D034741:RNA, Small Interfering / Q000235:genetics*; D016601:RNA-Binding Proteins; D012324:RNA-Dependent RNA Polymerase / Q000235:genetics*; D012568:Schizosaccharomyces / Q000235:genetics; D014158:Transcription, Genetic; D019076:Transgenes / Q000235:genetics
D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D034741:RNA, Small Interfering; D016601:RNA-Binding Proteins; C547653:elpc-1 proteins, C elegans; D012319:RNA Polymerase II; D012324:RNA-Dependent RNA Polymerase