Highly efficient cyanoimidation of aldehydes.
Cyanoimidation of aldehydes using cyanamide as a nitrogen source and using NBS as an oxidant was achieved in high yields without the addition of a catalyst. The method has several advantages, including mild conditions, simple workflow, and inexpensive reagents. The reaction proceeds in a one-pot manner, giving rise to the formation of intermolecular C-N and C-O bonds. Subsequently, the substituted N-cyanobenimidate products may also undergo a cyclization reaction to give l,2,4-triazole derivatives in high yields.
Yin
Ping
P
Key Laboratory of Drug-Targeting and Drug-Delivery Systems of the Ministry of Education, Department of Medicinal Chemistry,West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, 610041, PR China.
Ma
Wen-Bo
WB
Chen
Yue
Y
Huang
Wen-Cai
WC
Deng
Yong
Y
He
Ling
L
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D016877:Oxidants / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000447:Aldehydes; D009570:Nitriles; D016877:Oxidants; D014230:Triazoles