title: Voxel-based analysis of diffusion tensor imaging in mild traumatic brain injury in adolescents.
abstract: OBJECTIVE
  DTI of normal-appearing WM as evaluated by conventional MR imaging in mTBI has the potential to identify important regional abnormalities that relate to PCS. VBA was used to examine WM changes in acute mTBI.
  
  
  METHODS
  WM was assessed between 1 and 6 days postinjury with voxel-based DTI analyses in 10 adolescent patients with mTBI and 10 age-matched control participants. In addition to the voxel-based group, analysis used to identify brain pathology across all patients with mTBI, 2 voxel-based linear regressions were performed. These analyses investigated the relation between 1) the ADC and PCS severity scores, and 2) ADC and scores on the BSI of emotional symptoms associated with mTBI. We hypothesized that frontotemporal WM changes would relate to symptoms associated with PCS and endorsed on the BSI.
  
  
  RESULTS
  Patients with mTBI demonstrated significant reductions in ADC in several WM regions and in the left thalamus. As expected, no increases in ADC were found in any region of interest. All injury-affected regions showed decreased radial diffusivity, unchanged AD, and increased FA, which is consistent with axonal cytotoxic edema, reflective of acute injury.
  
  
  CONCLUSIONS
  Whole-brain WM DTI measures can detect abnormalities in acute mTBI associated with PCS symptoms in adolescents.
authors: E B Singleton Department of Diagnostic Imaging, Texas Children's Hospital, Houston, TX 77030, USA. zxchu@texaschildrens.org
authors: Z
authors: Z
authors: Chu
authors: E A
authors: EA
authors: Wilde
authors: J V
authors: JV
authors: Hunter
authors: S R
authors: SR
authors: McCauley
authors: E D
authors: ED
authors: Bigler
authors: M
authors: M
authors: Troyanskaya
authors: R
authors: R
authors: Yallampalli
authors: J M
authors: JM
authors: Chia
authors: H S
authors: HS
authors: Levin
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D001929:Brain Edema / Q000473:pathology; D001930:Brain Injuries / Q000473:pathology*; D002648:Child; D056324:Diffusion Tensor Imaging / Q000379:methods*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D015599:Trauma Severity Indices