title: Detecting alterations in cell ultrastructure with optical imaging.
abstract: Understanding cell functioning at the nanoscale has been hampered in part by the diffraction limited resolution of optical microscopy. We developed partial wave spectroscopic (PWS) microscopy that is capable of quantifying statistical properties of cell structure at the nanoscale. Our animal and human studies demonstrated that alterations in the nanoscale cell architecture is one of the earliest events in carcinogenesis and precedes any other known morphological changes at larger length scales (i.e. microarchitecture).
authors: Northwestern University, Evanston, IL 60208, USA. backman@northwestern.edu
authors: Vadim
authors: V
authors: Backman
authors: Hariharan
authors: H
authors: Subramanian
authors: Prabhakar
authors: P
authors: Pradhan
authors: Yang
authors: Y
authors: Liu
authors: Ilker
authors: I
authors: Capoglu
authors: Jeremy D
authors: JD
authors: Rogers
authors: Hemant K
authors: HK
authors: Roy
authors: Allen
authors: A
authors: Taflove
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000473:pathology* / Q000648:ultrastructure*; D007089:Image Enhancement / Q000379:methods*; D007414:Intestinal Neoplasms / Q000473:pathology* / Q000648:ultrastructure*; D007422:Intestines / Q000648:ultrastructure*; D051379:Mice; D012031:Refractometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity