title: The oxidative state of children with cyanotic and acyanotic congenital heart disease.
abstract: OBJECTIVE
  The type of congenital heart disease, early diagnosis, and treatment modality all play an important role in the morbidity and mortality of these diseases. This study examined the relationship between congenital heart disease and oxidative stress in children with cyanotic and acyanotic congenital heart disease.
  
  
  METHODS
  In this case-controlled cross-sectional study, the study groups consisted of 29 patients with cyanotic heart disease, 30 patients with acyanotic heart disease, and a control group of 32 healthy individuals. For all groups, the total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) were calculated. Of the cyanotic group, 12 were diagnosed with tetralogy of Fallot, 7 with transposition of the great arteries, 4 with tricuspid atresia, 4 with double outlet right ventricle and 2 with truncus arteriosus. In the acyanotic group 19 patients had ventricular septal defect (VSD), 5 atrial septal defect (ASD) and 6 patent ductus arteriosus (PDA). Statistical analyses were performed using Chi-square, Mann-Whitney U and Kruskal-Wallis tests.
  
  
  RESULTS
  The plasma TAS, TOS, and OSI were significantly higher in the cyanotic group than in the acyanotic group (p<0.0001, p<0.01, and p<0.01, respectively) and controls (p<0.0001, p<0.0001, and p<0.0001, respectively). A comparison between the acyanotic and control groups showed no statistical differences.
  
  
  CONCLUSIONS
  The level of oxidative stress in patients with cyanotic congenital heart disease was significantly higher than in the acyanotic and control groups, which were similar.
authors: Department of Pediatrics, Harran University School of Medicine, Sanliurfa, Turkey.
authors: Sümeyye
authors: S
authors: Ercan
authors: Alpay
authors: A
authors: Cakmak
authors: Mustafa
authors: M
authors: Kösecik
authors: Ozcan
authors: O
authors: Erel
mesh_terms: D017668:Age of Onset; D000975:Antioxidants / Q000378:metabolism; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000145:classification / Q000453:epidemiology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003490:Cyanosis / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D008297:Male; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress; D012016:Reference Values
chemical_list: D000975:Antioxidants; D016877:Oxidants