Infectious mononucleosis hepatitis in young adults: two case reports.
Infectious mononucleosis due to Epstein-Barr virus (EBV) infection sometimes causes acute hepatitis, which is usually self-limiting with mildly elevated transaminases, but rarely with jaundice. Primary EBV infection in children is usually asymptomatic, but in a small number of healthy individuals, typically young adults, EBV infection results in a clinical syndrome of infectious mononucleosis with hepatitis, with typical symptoms of fever, pharyngitis, lymphadenopathy, and hepatosplenomegaly. EBV is rather uncommonly confirmed as an etiologic agent of acute hepatitis in adults. Here, we report two cases: the first case with acute hepatitis secondary to infectious mononucleosis and a second case, with acute hepatitis secondary to infectious mononucleosis concomitantly infected with hepatitis A. Both cases involved young adults presenting with fever, pharyngitis, lymphadenopathy, hepatosplenomegaly, and atypical lymphocytosis confirmed by serologic tests, liver biopsy and electron microscopic study.
Kang
Min-Jung
MJ
Department of Internal Medicine, Clinical Research Institute, Ewha Womans University School of Medicine, Seoul, Korea.
Kim
Tae-Hun
TH
Shim
Ki-Nam
KN
Jung
Sung-Ae
SA
Cho
Min-Sun
MS
Yoo
Kwon
K
Chung
Kyu Won
KW
D000208:Acute Disease; D000328:Adult; D018414:CD8-Positive T-Lymphocytes / Q000821:virology; D005260:Female; D006505:Hepatitis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications*; D008099:Liver / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D055815:Young Adult