Activation of the C-H bond by electrophilic attack: theoretical study of the reaction mechanism of the aerobic oxidation of alcohols to aldehydes by the Cu(bipy)(2+)/2,2,6,6-tetramethylpiperidinyl-1-oxy cocatalyst system.
We have investigated the reaction mechanism of the selective aerobic oxidation of primary alcohols into aldehydes using a bipy-copper complex and the 2,2,6,6-tetramethylpiperidinyl-1-oxy (TEMPO) radical as cocatalysts (Gamez et al. Chem. Commun. 2003, 2412-2415) and compared it to the well-known oxidation by the TEMPO(+) ion. Our theoretical investigation shows that (a) the oxidation of alcohols to aldehydes by uncoordinated TEMPO(+) takes place by electrophilic attack on the C-H(alpha) bond of the alcohol; (b) the Cu(bipy)(2+) complex has two functions, namely, (1) it acts as a template that brings TEMPO and the (deprotonated) alcohol in proximity by coordinating these moieties in adjacent coordination sites, and (2) it oxidizes the TEMPO radical to (coordinated) TEMPO(+) ion. The H abstraction from alcohol by TEMPO(+) then proceeds as an intramolecular reaction, very much analogous to one of the reaction pathways with free TEMPO(+) and with a remarkably low barrier. We stress that compared to other A-H bonds (A = C, N, O, F), the relatively high-lying C-H bonds are particularly susceptible to electrophilic attack, and notably the C-H(alpha) bond next to the O in an alcohol is so because it is pushed up by an O lone pair. Electrophilic attack, being common to the particular catalytic system studied in this paper and the well-known biotic and abiotic oxidation catalysis by heme and non-heme complexes of the ferryl (Fe(IV)O(2+)) ion, appears to be a unifying electronic structure principle of C-H(alpha) hydroxylation and oxidation reactions.
Michel
Carine
C
Theoretical Chemistry, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
Belanzoni
Paola
P
Gamez
Patrick
P
Reedijk
Jan
J
Baerends
Evert Jan
EJ
D000438:Alcohols / Q000737:chemistry*; D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003198:Computer Simulation; D003300:Copper / Q000737:chemistry; D018360:Crystallography, X-Ray; D003497:Cyclic N-Oxides / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*
D000438:Alcohols; D000447:Aldehydes; D003497:Cyclic N-Oxides; D005609:Free Radicals; D009942:Organometallic Compounds; D010087:Oxides; D003300:Copper; C003959:TEMPO