Aminocaprophenone- and pyrrolidine-type alkaloids from the leaves of Ficus septica.
Two new aminocaprophenone alkaloids, ficuseptamines A (1) and B (2), and a new pyrrolidine alkaloid, ficuseptamine C (3), together with 12 known alkaloids and a known acetophenone derivative were isolated from a methanolic extract of the leaves of Ficus septica. The structures of 1-3 were determined on the basis of their spectroscopic data. The compounds obtained were evaluated for cytotoxicity against two cancer cell lines.
Ueda
Jun-ya
JY
Biomedicinal Information Research Center, Japan Biological Informatics Consortium, 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan.
Takagi
Motoki
M
Shin-ya
Kazuo
K
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D030681:Ficus / Q000737:chemistry*; D006801:Humans; D007564:Japan; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D011759:Pyrrolidines; C546370:ficuseptamine A; C546371:ficuseptamine B; C546369:ficuseptamine C