title: A platform for in silico modeling of physiological systems III.
abstract: Physiome and systems biology have been recognized as emerging and important research areas that can integrate quantitatively growing knowledge about biological structure and physiological functions at multiple scales of time and space. For the integration, it is important to build physiologically plausible and sharable mathematical models that can be used for dynamic simulations of functions at multi-scale and multi-level. Here we describe new features of our open platform insilicoML (ISML) and insilicoIDE (ISIDE) that have been presented previously. The platform can support reuse existing mathematical models of physiological functions in the model databases, to construct brand new models, and to simulate models. The major new features of the platform include improvement of the capabilities to incorporate experimentally obtained data such as time-series and morphological data with dynamic simulation of models that may be driven by the data, and extension of variety of model types that can be described by ISML and simulated on ISIDE, such as multi agent systems and models described by partial differential equations that are solved by the finite element method.
authors: Graduate School of Engineering Science at Osaka University, Toyonaka, Osaka 560-8531, Japan. suzuki@bpe.es.osaka-u.ac.jp
authors: Yasuyuki
authors: Y
authors: Suzuki
authors: Yoshiyuki
authors: Y
authors: Asai
authors: Hideki
authors: H
authors: Oka
authors: Eric
authors: E
authors: Heien
authors: Takahito
authors: T
authors: Urai
authors: Tatsuhide
authors: T
authors: Okamoto
authors: Yosuke
authors: Y
authors: Yumikura
authors: Keisuke
authors: K
authors: Tominaga
authors: Yoshiyuki
authors: Y
authors: Kido
authors: Masao
authors: M
authors: Nakanishi
authors: Kenichi
authors: K
authors: Hagihara
authors: Yoshihisa
authors: Y
authors: Kurachi
authors: Taishin
authors: T
authors: Nomura
mesh_terms: D019295:Computational Biology / Q000379:methods*; D003196:Computer Graphics; D003198:Computer Simulation; D020342:Finite Element Analysis; D006321:Heart / Q000502:physiology; D006801:Humans; D008390:Markov Chains; D008954:Models, Biological; D008962:Models, Theoretical; D011381:Programming Languages; D012984:Software; D012985:Software Design; D014584:User-Computer Interface