The renaissance of alpha-methylene-gamma-butyrolactones: new synthetic approaches.
The amount of research activity concerning alpha-methylene-gamma-butyrolactones and alpha-alkylidene-gamma-butyrolactones has increased dramatically in recent years. This Review summarizes the structural types, biological activities, and biosynthesis of these compounds, concentrating on publications from the past 10 years. Traditional approaches to alpha-methylene-gamma-butyrolactones and alpha-alkylidene-gamma-butyrolactones are then reviewed together with novel approaches, including those from our own research group, reported more recently.
Kitson
Russell R A
RR
Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
Millemaggi
Alessia
A
Taylor
Richard J K
RJ
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000138:chemical synthesis / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D015394:Molecular Structure; D013329:Structure-Activity Relationship
C014096:alpha-methylene gamma-butyrolactone; D015107:4-Butyrolactone