Target Controlled Infusion algorithms for anesthesia: theory vs practical implementation.
Target Controlled Infusion (TCI) systems are based in drug pharmacokinetic and pharmacodynamic models implemented in an algorithm to drive an infusion pump. Infusion control algorithms have been designed, implemented and validated for several anesthetic drugs, devices and controllers. The maintenance phase in these algorithms is represented by an equation that compensates the loss of drug from the central compartment and maintains the set target concentration. The goal of the current study was to improve existing TCI software with a new method for the maintenance phase. We compared and analyzed two different methods to find the more efficient method for the maintenance phase in an open-loop control TCI system.
Bressan
Nadja
N
University of Porto, Faculty of Engineering, Department of Electrical and Computer Engineering, Portugal. nadja.bressan@fe.up.pt
Moreira
A Paulo
AP
Amorim
Pedro
P
Nunes
Catarina S
CS
D000465:Algorithms; D018681:Anesthetics, General / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D003198:Computer Simulation; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D006801:Humans; D007262:Infusions, Intravenous; D008954:Models, Biological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D018681:Anesthetics, General