Increased functional and structural skin capillary density in type 1 diabetes patients with vascular complications.
The present study was designed to study skin capillary density and recruitment of the upper and lower extremities in patients with type 1 diabetes with vascular complications, when compared to patients without complications and healthy subjects. We used intravital video-microscopy to measure basal and maximal (during venous congestion) skin capillary densities as well as capillary recruitment using post-occlusive reactive hyperemia (PORH) in the dorsum of the fingers and toes.Our results showed that besides microvascular vasodilation and loss of autoregulatory capacity, patients with type 1 diabetes with vascular complications present increased skin capillary density in both extremities.
Tibiriçá
Eduardo
E
Department of Medicine, Diabetes Unit, State University of Rio de Janeiro, Rio de Janeiro, Brazil. etibi@ioc.fiocruz.br
Rodrigues
Elba
E
Cobas
Roberta
R
Gomes
Marilia B
MB