[Study advancement of calpain and apoptosis following cerebral ischemia].
Calpains, calcium-activated cysteine proteases with a neutral pH optimum, lead to degration of cystoskeletion and structural protein, and delayed neuronal death. The activation of calpains contribute to apoptosis. Calpain inhibitors provide a novel and potential treatment for cerebral ischemia due to improvement of cerebral infarct and ischemia.
Liu
Jian
J
Institue of Acupuncture and Moxibustion, Frist Teaching Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Xu
Junfeng
J
Wang
Guangjun
G
Yang
Mingxing
M
Guo
Lin
L
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000627:therapeutic use*; D002154:Calpain / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D006801:Humans
D002135:Calcium-Binding Proteins; C033668:calpastatin; D002154:Calpain