Evaluation of Brazilian plants on cancer chemoprevention targets in vitro.
Cancer is a leading cause of death worldwide. Cancer chemoprevention is one of the promising strategies to decrease its incidence and both plant extracts and natural products may constitute sources of new chemoprevention agents. Some Brazilian species popularly used to treat inflammatory conditions were selected for evaluation for cancer chemoprevention. A total of 32 extracts/fractions from Hancornia speciosa, Davilla elliptica, Jacaranda caroba, Mansoa hirsuta, Remija ferrugina, Solanum paniculatum and Xyris pterygoblephara, along with a mixture of ursolic and oleanolic acids obtained from J. caroba and a dihydroisocoumarin isolated from aerial parts of X. pterygoblephara were tested for their cancer chemoprevention activity [inhibition of 12-O-tetradecanoyl-13-acetate (TPA)-mediated NF-kappaB activation, ornithine decarboxylase (ODC) and cyclooxygenase-1 (COX-1); induction of antioxidant response element (ARE)]. Several extracts/fractions were active in more than one assay and those from H. speciosa, M. hirsuta and J. caroba mediated strong responses with NF-kappaB, COX-1 and ARE, respectively.
Endringer
Denise C
DC
Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Valadares
Ydia M
YM
Campana
Priscilla R V
PR
Campos
Jussara J
JJ
Guimarães
Keller G
KG
Pezzuto
John M
JM
Braga
Fernão C
FC
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001938:Brazil; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry*; D016328:NF-kappa B / Q000378:metabolism; D009955:Ornithine Decarboxylase / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D016861:Cyclooxygenase Inhibitors; D016328:NF-kappa B; D010936:Plant Extracts; D009955:Ornithine Decarboxylase