Glutathione-S-transferase (GSTM1, GSTT1) and the risk of gastrointestinal cancer in a Korean population.
OBJECTIVE
To evaluate the association of glutathione S-transferase mu (GSTM1) and glutathione S-transferase theta (GSTT1) null genotypes with the risk of gastric cancer (GC) and colorectal cancer (CRC) in a South Korean population.


METHODS
We conducted a population-based, large-scale case-control study including 2213 GCs, 1829 CRCs, and 1699 controls. Null and non-null genotypes of GSTM1 and GSTT1 were determined using real-time PCR.


RESULTS
The null genotypes of GSTM1 and GSTT1 were not significantly associated with elevated risk of gastric (OR = 1.070, 95% CI = 0.935-1.224; OR = 1.101, 95% CI = 0.963-1.259, respectively) or colorectal cancer (OR = 1.065, 95% CI = 0.923-1.228; OR = 1.041, 95% CI = 0.903-1.200, respectively). The frequency of the combined null GST genotype was not different between the two cancer groups and controls. Moreover, smoking, drinking, and age did not modify the association between these genotypes and the risk of gastric or colorectal cancer.


CONCLUSIONS
GSTM1 and GSTT1 null genotypes were not associated with increased risk of GC or CRC in Koreans.
Piao
Jin-Mei
JM
Department of Preventive Medicine, Chonnam National University Medical School, Donggu, Gwangju City, South Korea.
Shin
Min-Ho
MH
Kweon
Sun-Seog
SS
Kim
Hee Nam
HN
Choi
Jin-Su
JS
Bae
Woo-Kyun
WK
Shim
Hyun-Jeong
HJ
Kim
Hyeong-Rok
HR
Park
Young-Kyu
YK
Choi
Yoo-Duk
YD
Kim
Soo-Hyun
SH
D000368:Aged; D044466:Asian People / Q000235:genetics*; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1