title: [Some fundamental notions of oncomorphology in the light of modern molecular biology advances].
abstract: Introduction of molecular biological studies into oncomorphology has made investigators reconsider many fundamental notions of the histogenesis, morphogenesis, and microscopic structure of human neoplasms. Tumor cell differentiation is a more dynamic process, a less fixed concept; hence it is necessary to do away with the rigid frameworks of cancer nosological entities and with a number of postulates on tumor histogenesis, including the rudiments of blastemic tissue changed during embryogenesis. The morphogenesis of a tumor has proven to be frequently determined by the variants of the specific translocations that may, in addition to its miscroscopic structure, affect a great variety of the clinical manifestations of disease. The molecular portrait of a tumor, the result of gene expression peculiarities can substitute for traditional cancer nosological entities although new classifications should be based on advances in oncomorphology.
authors: A I
authors: AI
authors: Karseladze
mesh_terms: D000818:Animals; D047108:Embryonic Development / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D052138:Genes, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000145:classification / Q000235:genetics / Q000378:metabolism / Q000473:pathology