[Granulocytic sarcoma, a diagnostic challenge: 3 pediatric cases].
Granulocytic sarcoma (GS) is a rare extramedullary tumor frequently associated with acute myeloblastic leukemia (AML). We report 3 cases of pediatric granulocytic sarcomas with various locations: skin, orbit, and bowel. Cases 1 and 2 were associated with AML; case 3 was isolated. In all 3 cases, the diagnosis was delayed or initially missed. Pathology and immunohistochemistry data identified the disease. GS is treated with chemotherapy, like AML. The prognosis of GS seems better than that of isolated AML.
Rénard
C
C
Institut d'hématologie et d'oncologie pédiatrique, 1, place Joseph-Renaut, 69008 Lyon, France. cecilerenard@wanadoo.fr
Girard
S
S
Pracros
J P
JP
Dijoud
F
F
André
J-M
JM
Mialou
V
V
Bertrand
Y
Y
D000971:Antineoplastic Combined Chemotherapy Protocols; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003951:Diagnostic Errors; D005153:Facial Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007414:Intestinal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D007421:Intestine, Small; D015456:Leukemia, Biphenotypic, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D023981:Sarcoma, Myeloid / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D014057:Tomography, X-Ray Computed