Gefitinib trial in a fanconi's anemia patient with multiple squamous cell carcinomas and hepatocellular carcinoma.
FA (Fanconi's Anemia) is an autosomal recessive disorder that is characterized by pancytopenia with bone marrow hypoplasia, diverse congenital abnormalities and an increased predisposition towards malignancy. The mainstay of the treatment for these cancers has been surgery, because of the hypersensitive reactions of FA patients to DNA cross- linking agents or radiation. Therefore, there has been no effective therapy for advanced squamous cell carcinoma. We report here on a patient suffering from advanced multiple squamous cell carcinoma and hepatocellular carcinoma along with an FA, and this patient was treated with gefitinib.
Jung
Hae Sun
HS
Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea.
Byun
Gun-Woo
GW
Lee
Kyoung-Eun
KE
Mun
Yeung Chul
YC
Nam
Seung Hyun
SH
Kwon
Jung Mi
JM
Lee
Shi Nae
SN
Im
Seock-Ah
SA
Seong
Chu-Myong
CM
Lee
Soon Nam
SN