title: Multidisciplinary approach for in-deep assessment of joint prosthesis failure.
abstract: In spite of advancement in biomaterials and biomechanics, in development of new osteo-integrative materials and coatings, and in macro- micro- component design, a non negligible fraction of the implanted prosthesis fails before the expected lifetime. A prospective observational clinical study has been conducted to define and apply a set of experimental techniques to in-deep assess the failure of joint prosthesis. Microbiological, histological and micro-structural techniques were implemented to specifically address phenomena occurring at the tissue-implant interface. Results obtained from 27 cases of prosthetic joint failure are discussed in terms of sensitivity and specificity. A procedural flow-chart is finally proposed for the assessment of joint prosthesis failure.
authors: Interdepartmental Centre for Biotechnologies and Department of Physics, University of Trento, 35100, Trento, Italy. tessaro@science.unitn.it
authors: F
authors: F
authors: Tessarolo
authors: I
authors: I
authors: Caola
authors: F
authors: F
authors: Piccoli
authors: P
authors: P
authors: Dorigotti
authors: E
authors: E
authors: Demattè
authors: M
authors: M
authors: Molinari
authors: M
authors: M
authors: Malavolta
authors: M
authors: M
authors: Barbareschi
authors: P
authors: P
authors: Caciagli
authors: G
authors: G
authors: Nollo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019643:Arthroplasty, Replacement / Q000379:methods*; D001672:Biocompatible Materials / Q000737:chemistry; D001696:Biomechanical Phenomena; D005260:Female; D006801:Humans; D007595:Joint Prosthesis; D007596:Joints / Q000473:pathology; D008297:Male; D008422:Materials Testing; D008828:Microbiological Techniques; D008875:Middle Aged; D011446:Prospective Studies; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012107:Research Design
chemical_list: D001672:Biocompatible Materials