title: A comparison of posterolateral lumbar fusion comparing autograft, autogenous laminectomy bone with bone marrow aspirate, and calcium sulphate with bone marrow aspirate: a prospective randomized study.
abstract: METHODS
  A prospective clinical study.
  
  
  OBJECTIVE
  To evaluate whether the fusion rate of autogenous laminectomy bone chips and calcium sulfate pellets could be augmented by bone marrow aspirate (BMA) in one-level lumbar posterolateral fusion.
  
  
  BACKGROUND
  An in vivo animal study has indicated that BMA augments spinal arthrodesis.
  
  
  METHODS
  Forty-three patients undergoing surgery for instrumented one-level fusion with decompression were divided into 2 groups. Autologous iliac crest bone graft (ICBG) was placed in 1 posterolateral gutter (control), while on the other side (test), an equal quantity of laminectomy bone chips mixed with BMA while harvesting the iliac bone graft (group 1) or an equal quantity of calcium sulfate pellets soaked in BMA (group 2) was placed. Radiographic assessment was performed every 3 months (3-12 months) and then annually. The statuses of fusion on either side of the vertebra were compared.
  
  
  RESULTS
  For the 21 patients in group 1, 18 (85.7%) exhibited bone fusion on the test side, and 19 (90.5%) presented evidence of fusion on the control side. Thus, the test side with laminectomy bone chips and BMA achieved a fusion rate similar to that on the control side (P > 0.05). For the 22 patients in group 2, 20 (90.9%) exhibited bone fusion on the control side whereas only 10 (45.5%) demonstrated complete fusion on the test side (P < 0.05), where calcium sulfate and BMA was applied.
  
  
  CONCLUSIONS
  ICBG performs as expected with high fusion rates and laminectomy bone with BMA performs equally as well. Osteoset is significantly inferior to ICBG despite the addition of BMA, which is osteoinductive and has improved fusion rates and osteogenesis in other models.
authors: Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
authors: Chi-Chien
authors: CC
authors: Niu
authors: Tsung-Ting
authors: TT
authors: Tsai
authors: Tsai-Sheng
authors: TS
authors: Fu
authors: Po-Liang
authors: PL
authors: Lai
authors: Lih-Huei
authors: LH
authors: Chen
authors: Wen-Jer
authors: WJ
authors: Chen
mesh_terms: D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D016026:Bone Marrow Transplantation / Q000379:methods*; D016025:Bone Transplantation / Q000379:methods*; D002133:Calcium Sulfate / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007085:Ilium / Q000637:transplantation; D007593:Joint Instability / Q000503:physiopathology; D007796:Laminectomy / Q000379:methods*; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010012:Osteogenesis / Q000502:physiology; D011446:Prospective Studies; D011859:Radiography; D013123:Spinal Fusion / Q000379:methods*; D013130:Spinal Stenosis / Q000503:physiopathology / Q000601:surgery; D013168:Spondylolisthesis / Q000503:physiopathology / Q000601:surgery; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D002133:Calcium Sulfate