Enhancement of the immune response to chronic myeloid leukaemia via controlled treatment scheduling.
We study the differential equations describing the chronic myeloid leukaemia. We propose a novel drug scheduling method to enhance the T-cell mediated immune response. The control strategy relies on the understanding of the immune boosting mechanism. The feasibility of the strategy is illustrated via simulations.
Chang
H
H
Department of Electrical and Electronic Engineering, Imperial College, London, UK. hj.chang05@ic.ac.uk
Astolfi
A
A
D000465:Algorithms; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D019496:Cancer Vaccines; D019295:Computational Biology / Q000379:methods; D003198:Computer Simulation; D004334:Drug Administration Schedule; D004358:Drug Therapy / Q000379:methods*; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects; D015233:Models, Statistical; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors
D000970:Antineoplastic Agents; D019496:Cancer Vaccines