[Piezoelectric property of novel biological piezoelectric ceramic HALNK and its effect on the functional expression of rat osteoblast cells].
OBJECTIVE
To test the Piezoelectric property of novel biological piezoelectric ceramic HALNK and its effect on the proliferation and differentiation of rat osteoblast cells.


METHODS
The biological piezoelectric ceramic HALNK1/9 and HALNK5/5 were prepared by mixing Hydroxyapatite (HA) with lithium sodium potassium niobate (LNK) piezoelectric ceramic at a ratio of 1/9 and 5/5 (wt/wt), respectively. After poling treatment, the piezoelectric constants were measured. The osteoblast cells were then seeded on the surfaces of HALNK. The proliferation and differentiation activities of the osteoblast cells were evaluated by MTT assays, ALP activities and scanning electron microscopy examinations.


RESULTS
Cells grown on the surfaces of HALNK showed normal morphology, and had better proliferation and differentiation activities than the control. The growth of osteoblastic cells on the surface of HALNK1/9 was significantly better than others.


CONCLUSIONS
The surface of HALNK 1/9 possesses better piezoelectric property and osteogenesis potential than HALNK5/5.
Wang
Peng
P
Department of General Surgery, Affiliation Hospital of Hebei University, Baoding, China.
Zhang
Jin-Chao
JC
Zhang
Xiao-Zhou
XZ
Liu
Zhi-Qin
ZQ
Chen
Que-Ting
QT
Sun
Jing
J
Chen
Zhi-Qing
ZQ
D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation / Q000528:radiation effects; D049109:Cell Proliferation / Q000528:radiation effects; D002516:Ceramics; D017886:Durapatite / Q000737:chemistry; D004581:Electronics / Q000295:instrumentation; D004735:Energy Transfer; D004867:Equipment Design; D008094:Lithium / Q000737:chemistry; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D010006:Osteoblasts / Q000166:cytology* / Q000528:radiation effects; D051381:Rats; D012886:Skull / Q000166:cytology; D012964:Sodium / Q000737:chemistry
D017886:Durapatite; D008094:Lithium; D012964:Sodium