title: A preliminary study on pro- and anti-inflammatory cytokine profiles in Plasmodium vivax malaria patients from central zone of India.
abstract: The aim of this preliminary study was to investigate the plasma cytokine profiles in a group of patients suffering from Plasmodium vivax malaria during the peak of its transmission season. Plasma samples of 173 P. vivax patients and 34 healthy individuals were analyzed for IFN-gamma, TNF-alpha, IL-10 and IP-10 levels by ELISA. Levels of both pro- and anti-inflammatory cytokines were significantly higher in P. vivax patients compared to controls. Children with P. vivax infection had significantly higher levels of IFN-gamma than adults (P=0.017). Asexual parasitaemia versus TNF-alpha (r=-0.31, P=0.01), IL-10 (r=-0.30, P=0.015) and gametocytaemia versus IFN-gamma (r=-0.26; P=0.034) levels showed significant negative correlation in children compared to adults. The median concentrations of IFN-gamma (P=0.001), IL-10 (P=0.032) and IP-10 (P</=0.05) were higher in children reported with chills and rigors, whereas in adults only IFN-gamma levels was higher (P<0.0001). The median plasma concentrations of IFN- gamma (P=0.02), IL-10 (P<0.0001) and IP-10 (P=0.068) were higher in patients with mild anaemia compared to non-anaemic patients. The results indicated that both pro- and anti-inflammatory cytokine responses are associated with clinical signs of mild anaemia and paroxysm during symptomatic P. vivax malaria in Central India.
authors: National Institute of Malaria Research, FS-Jabalpur, MP, India.
authors: Vidhan
authors: V
authors: Jain
authors: Puspendra P
authors: PP
authors: Singh
authors: Nipun
authors: N
authors: Silawat
authors: Rakesh
authors: R
authors: Patel
authors: Ajay
authors: A
authors: Saxena
authors: Praveen K
authors: PK
authors: Bharti
authors: Manmohan
authors: M
authors: Shukla
authors: Sukla
authors: S
authors: Biswas
authors: Neeru
authors: N
authors: Singh
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D007194:India; D016780:Malaria, Vivax / Q000276:immunology* / Q000473:pathology; D008297:Male; D018512:Parasitemia; D010949:Plasma / Q000737:chemistry; D010966:Plasmodium vivax / Q000276:immunology*; D055815:Young Adult
chemical_list: D016207:Cytokines