title: Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma.
abstract: Cutaneous T-cell lymphomas most commonly have a CD4(+) memory T-cell phenotype with relatively indolent course, but may in rare cases present with a CD8(+) cytotoxic phenotype exhibiting strikingly more aggressive clinical behavior. We present two cases of the clinically aggressive subtype of primary cutaneous epidermotropic CD8(+) cutaneous T-cell lymphoma and review the current literature, clinical behavior, and recommendations for treatment distinct from that of more common CD4(+) variants of cutaneous T-cell lymphoma.
authors: Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
authors: Rachel H
authors: RH
authors: Gormley
authors: Stephen D
authors: SD
authors: Hess
authors: Dipti
authors: D
authors: Anand
authors: Jacqueline
authors: J
authors: Junkins-Hopkins
authors: Alain H
authors: AH
authors: Rook
authors: Ellen J
authors: EJ
authors: Kim
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000077610:Bexarotene; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003131:Combined Modality Therapy; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D008297:Male; D012867:Skin / Q000276:immunology; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D013764:Tetrahydronaphthalenes / Q000627:therapeutic use
chemical_list: D013764:Tetrahydronaphthalenes; D000077610:Bexarotene