title: In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones.
abstract: The in vitro screening of 43 polysubstituted chalcones against Leishmania amazonensis axenic amastigotes, led to the evaluation of 9 of them in a macrophage-infected model with the two other most infectious Leishmania species prevalent in Peru (L. braziliensis and L. peruviana). The five most active and selective chalcones were studied in vivo, resulting on the identification of two chalcones with high reduction parasite burden percentages.
authors: Department of Chemistry, University of Louisville, KY 40292, USA.
authors: José C
authors: JC
authors: Aponte
authors: Denis
authors: D
authors: Castillo
authors: Yannick
authors: Y
authors: Estevez
authors: German
authors: G
authors: Gonzalez
authors: Jorge
authors: J
authors: Arevalo
authors: Gerald B
authors: GB
authors: Hammond
authors: Michel
authors: M
authors: Sauvain
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007891:Leishmania / Q000187:drug effects; D008264:Macrophages / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D021261:Parasitic Sensitivity Tests
chemical_list: D000981:Antiprotozoal Agents; D047188:Chalcones