PI3K regulatory subunits lose control in cancer.
The PI3K signaling axis is frequently activated in cancer resulting from inactivation of its negative regulator PTEN or activating mutations of the p110alpha catalytic subunit of PI3K. In this issue of Cancer Cell, Jaiswal et al. report that mutations in the p85alpha regulatory subunit of PI3K can also activate this pathway in cancer.
Berenjeno
Inma Martin
IM
Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Martin-Berenjeno
Inma
I
Vanhaesebroeck
Bart
B
D020134:Catalytic Domain; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000201:enzymology*; D019869:Phosphatidylinositol 3-Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
D019869:Phosphatidylinositol 3-Kinases