New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities.
The synthesis of several (1,2,3,5,6,7-hexahydro-1,5:3,7-dimethano-4-benzoxonin-3-yl)amines and related compounds is reported. Several of them display very similar activity to memantine as NMDA receptor antagonists. Several derivatives showed a significant level of trypanocidal activity.
Duque
María D
MD
Laboratori de Química Farmacèutica, Unitat Associada al CSIC, Facultat de Farmàcia, and Institute of Biomedicine, Universitat de Barcelona, Av Diagonal, 643, Barcelona E-08028, Spain.
Camps
Pelayo
P
Torres
Eva
E
Valverde
Elena
E
Sureda
Francesc X
FX
López-Querol
Marta
M
Camins
Antoni
A
Prathalingam
S Radhika
SR
Kelly
John M
JM
Vázquez
Santiago
S
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000978:Antiparkinson Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D008559:Memantine / Q000494:pharmacology; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014344:Trypanocidal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects; D014352:Trypanosomiasis / Q000188:drug therapy
D000588:Amines; D000978:Antiparkinson Agents; D016194:Receptors, N-Methyl-D-Aspartate; D014344:Trypanocidal Agents; D008559:Memantine