title: Expanding the scope of cinchona alkaloid-catalyzed enantioselective alpha-aminations of oxindoles: a versatile approach to optically active 3-amino-2-oxindole derivatives.
abstract: A cinchona alkaloid-catalyzed, highly enantioselective, alpha-amination of oxindoles has been developed. The reaction is general, operationally simple, and affords the desired products in high yields with good to excellent enantioselectivity. Significantly, this study provides a general catalytic method for the construction of a C-N bond at the C3 position of oxindoles as well as for the creation of a nitrogen-containing, tetrasubstituted chiral center.
authors: Department of Chemistry, The Scripps Research Institute.
authors: Tommy
authors: T
authors: Bui
authors: Mar
authors: M
authors: Borregan
authors: Carlos F
authors: CF
authors: Barbas
mesh_terms: D000586:Amination; D002384:Catalysis; D002930:Cinchona Alkaloids / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D000078183:Oxindoles; D013237:Stereoisomerism
chemical_list: D002930:Cinchona Alkaloids; D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole