title: Clinicopathological analyses of fifty supracricoid laryngectomized specimens: evidence base supporting minimal margins.
abstract: OBJECTIVE
  Supracricoid laryngectomy (SCL) is a reliable laryngeal preservation surgery. However, close surgical margins are often inevitable. Based on clinicopathological analyses of supracricoid laryngectomized specimens, we evaluated the evidence base supporting minimal margins.
  
  
  METHODS
  The distance between tumor edge and resected margin was measured macro- and microscopically at the anterior, posterior, superior and inferior edges, using 50 surgical specimens. The margins were correlated with pathological T staging and the prognoses.
  
  
  RESULTS
  The anterior and posterior margins were the shortest, and the superior margin was the longest. The inferior margin was the only edge at which a positive margin was encountered. Cancer extending 10 mm below the glottal free edge significantly decreased the inferior margin.
  
  
  CONCLUSIONS
  The surgical potential of SCL with cricohyoidoepiglottopexy was confirmed to be able to cope with tumor extensions showing margins of a few millimeters at the anterior, posterior and superior ends. Accurate assessment and management at the inferior margin is the key to stable local control.
authors: Department of Otorhinolaryngology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. meijin@med.kitasato-u.ac.jp
authors: Meijin
authors: M
authors: Nakayama
authors: Christopher
authors: C
authors: Holsinger
authors: Makito
authors: M
authors: Okamoto
authors: Yutomo
authors: Y
authors: Seino
authors: Shunsuke
authors: S
authors: Miyamoto
authors: Masahiko
authors: M
authors: Takeda
authors: Satoru
authors: S
authors: Yokobori
authors: Takashi
authors: T
authors: Masaki
authors: Seiichi
authors: S
authors: Hayashi
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery*; D003413:Cricoid Cartilage / Q000473:pathology / Q000601:surgery; D004825:Epiglottis / Q000473:pathology / Q000601:surgery; D019317:Evidence-Based Medicine; D005260:Female; D005931:Glottis / Q000473:pathology / Q000601:surgery; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000517:prevention & control; D009367:Neoplasm Staging; D013957:Thyroid Cartilage / Q000473:pathology / Q000601:surgery