[Structural and functional condition of the left ventricle in patients with type 2 diabetes mellitus complicated with diabetic autonomic neuropathy].
The authors have studied structural functional peculiarities of the left ventricle in patients with type 2 diabetes mellitus, dependent on the presence of cardiovascular form of diabetic autonomic neuropathy and dynamics of the studied parameters in patients with type 2 diabetes mellitus complicated with cardiovascular form of diabetic autonomic neuropathy treated with alpha-lipoic acid. The study included 82 patients with type 2 diabetes mellitus. The study has shown that the development of cardiovascular form of diabetic autonomic neuropathy results in dilatation and hypertrophy of the left ventricle walls, increase of its weight and impairment of diastolic function of the left ventricle manifesting itself by a decrease of early filling phase and an increase of myocardial hardness, as well as a decrease of cardiac rhythm variability and increase of QT-interval. Use of alpha-lipoic acid in complex treatment of diabetic autonomic neuropathy contributes to more effective influencing on diastolic function of the left ventricle and electrophysiological properties of the myocardium.
Sadykova
H G
HG
Nazhmutdinova
D K
DK
D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D004359:Drug Therapy, Combination; D015150:Echocardiography, Doppler; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000187:drug effects / Q000294:innervation / Q000503:physiopathology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D008063:Thioctic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects* / Q000502:physiology
D007004:Hypoglycemic Agents; D008063:Thioctic Acid