title: 8-OHdG in cerebrospinal fluid as a marker of oxidative stress in various neurodegenerative diseases.
abstract: BACKGROUND
  The 8-hydroxy-2 deoxyguanosine (8-OHdG) is a product of nucleoside oxidation of DNA and a reliable marker of oxidative stress markers. Increased levels of oxidative stress have been reported in the cerebrospinal fluid (CSF) of patients with various neurodegenerative disorders.
  
  
  OBJECTIVE
  In search of a biochemical indicator of Parkinson's disease (PD), we analyzed the levels 8-OHdG in the CSF of 99 patients, using ELISA to assess the differences between various neurodegenerative disorders.
  
  
  RESULTS
  Statistically significant higher CSF levels (p = 0.022) of 8-OHdG in non-demented PD patients as compared to the control group were observed. No differences between CSF 8-OHdG levels and age at the time of lumbar puncture, presence or severity of dementia, or gender were found.
  
  
  CONCLUSIONS
  8-OHdG levels could be potentially useful in the neurochemically supported diagnosis of PD.
authors: Department of Neurology, Georg August University, DE-37075 Goettingen, Germany.
authors: K
authors: K
authors: Gmitterová
authors: U
authors: U
authors: Heinemann
authors: J
authors: J
authors: Gawinecka
authors: D
authors: D
authors: Varges
authors: B
authors: B
authors: Ciesielczyk
authors: P
authors: P
authors: Valkovic
authors: J
authors: J
authors: Benetin
authors: I
authors: I
authors: Zerr
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000368:Aged; D000369:Aged, 80 and over; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000134:cerebrospinal fluid* / Q000145:classification / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology*; D012189:Retrospective Studies
chemical_list: D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine