title: Porphyrin-cyclodextrin conjugates as a nanosystem for versatile drug delivery and multimodal cancer therapy.
abstract: The porphyrin-cyclodextrin conjugates were prepared and tested for selective and effective multifunctional drug delivery and therapy. The porphyrin receptor system combines efficient binding of the selected drug to the cyclodextrin cavity and photosensitizing properties of the porphyrin moiety with high accumulation of the whole complex in cancer tissue. The combined effect of chemotherapy and photodynamic therapy is demonstrated by in vitro and in vivo studies.
authors: Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague 4, Czech Republic. kralv@vscht.cz
authors: Jarmila
authors: J
authors: Králová
authors: Zdenek
authors: Z
authors: Kejík
authors: Tomás
authors: T
authors: Bríza
authors: Pavla
authors: P
authors: Poucková
authors: Ales
authors: A
authors: Král
authors: Pavel
authors: P
authors: Martásek
authors: Vladimír
authors: V
authors: Král
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D003505:Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D036103:Nanotechnology; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D003505:Cyclodextrins; D011166:Porphyrins