[Changes of the brain stem neurocytes in newborn rats in the conditions of experimental model of hypoxia during neuroprotective correction].
The work includes a research of morphological and immune-histochemical specifics of baby rats' cerebral structures in the conditions of experimental hypoxia model and with the administration of Cerebrocurin. It was ascertained that the most pronounced changes in the form of pericellular and perivascular edema, spongiform loci and loci of necrosis, with the phenomena of apoptosis and aponeuroses, occurred during severe hypoxia. Administration of Cerebrocurin in baby rats, which experienced moderate hypoxia, causes a decrease in pathological changes in cerebral structures and the approximation of the level of CD95 APO-1/Fas and Bcl-21 gene expression to their level in intact animals.
Znamens'ka
T K
TK
Pokhyl'ko
V I
VI
Koval'ova
O M
OM
Zadorozhna
T D
TD
Archakova
T M
TM
Rozova
K V
KV
D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis / Q000187:drug effects; D001927:Brain Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D001933:Brain Stem / Q000187:drug effects / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D015870:Gene Expression / Q000187:drug effects; D000860:Hypoxia / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D009474:Neurons / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D051381:Rats; D019014:fas Receptor / Q000235:genetics / Q000378:metabolism
D018696:Neuroprotective Agents; D019253:Proto-Oncogene Proteins c-bcl-2; D019014:fas Receptor