Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum.
In this study, we evaluated haplotypes of the bovine FCGRT (encoding the FcRn heavy chain) and their relationship to the IgG concentration in bovine colostrum. Four single nucleotide polymorphism (SNP), classified into five haplotypes, were identified in a total of 49 Holstein-Frisians cows. Haplotype 5 was found to be significantly associated with a high IgG level ([OR] = 9.90, 95%CI = 1.11-88.34, p = 0.016) and haplotype 2 exhibited a similar trend ([OR] = 2.89, 95%CI = 1.17-7.11, p = 0.019).
Zhang
Ran
R
State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, People's Republic of China.
Zhao
Zhihui
Z
Zhao
Yaofeng
Y
Kacskovics
Imre
I
Eijk
Marjolein van der
Mv
Groot
Nanda de
Nd
Li
Ning
N
Hammarstrom
Lennart
L
D000483:Alleles; D000818:Animals; D002417:Cattle / Q000235:genetics* / Q000276:immunology; D003126:Colostrum / Q000737:chemistry* / Q000276:immunology; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D011961:Receptors, Fc / Q000235:genetics* / Q000276:immunology
D015395:Histocompatibility Antigens Class I; D007074:Immunoglobulin G; D011961:Receptors, Fc; C100688:Fc receptor, neonatal