title: Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.
abstract: Undifferentiated pleomorphic sarcoma/Malignant Fibrous Histiocytoma (MFH) is one of the most common subtypes of human soft tissue sarcoma. Using cross species genomic analysis, we define a geneset from the LSL-Kras(G12D); Trp53(Flox/Flox) mouse model of soft tissue sarcoma that is highly enriched in human MFH. With this mouse geneset as a filter, we identify expression of the RAS target FOXM1 in human MFH. Expression of Foxm1 is elevated in mouse sarcomas that metastasize to the lung and tissue microarray analysis of human MFH correlates overexpression of FOXM1 with metastasis. These results suggest that genomic alterations present in human MFH are conserved in the LSL-Kras(G12D); p53(Flox/Flox) mouse model of soft tissue sarcoma and demonstrate the utility of this pre-clinical model.
authors: Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America.
authors: Jeffrey K
authors: JK
authors: Mito
authors: Richard F
authors: RF
authors: Riedel
authors: Leslie
authors: L
authors: Dodd
authors: Guy
authors: G
authors: Lahat
authors: Alexander J
authors: AJ
authors: Lazar
authors: Rebecca D
authors: RD
authors: Dodd
authors: Lars
authors: L
authors: Stangenberg
authors: William C
authors: WC
authors: Eward
authors: Francis J
authors: FJ
authors: Hornicek
authors: Sam S
authors: SS
authors: Yoon
authors: Brian E
authors: BE
authors: Brigman
authors: Tyler
authors: T
authors: Jacks
authors: Dina
authors: D
authors: Lev
authors: Sayan
authors: S
authors: Mukherjee
authors: David G
authors: DG
authors: Kirsch
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D020869:Gene Expression Profiling / Q000379:methods; D016158:Genes, p53; D016678:Genome; D023281:Genomics; D005838:Genotype; D051677:Histiocytoma, Malignant Fibrous / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D046228:Microarray Analysis; D009362:Neoplasm Metastasis; D012509:Sarcoma / Q000378:metabolism*; D012983:Soft Tissue Neoplasms / Q000378:metabolism; D013045:Species Specificity