[Effectiveness of ezetimibe in improving lipid goal attainment in patients with coronary heart diseases treated with statin].
OBJECTIVE
To investigate the efficacy and safety of ezetimibe on uncontrolled LDL-C when added to ongoing statin therapy in patients with coronary heart diseases (CHD) and diabetes mellitus (DM).


METHODS
61 patients with LDL-C level exceeding target goal (<2.07 mmol/L) after 12 weeks' treatment with statins, received ezetimibe in addition to their ongoing statin therapy for 8 weeks. Lipid parameters, alanine aminotransferase (ALT), aspartic aminotransferase (AST) and creatine kinase (CK) were compared before and after the adding of ezetimibe.


RESULTS
LDL-C before and after the adding of ezetimibe was (2.74+/-0.43) mmol/L and (2.19+/-0.32) mmol/L, respectively (P=0.03) in 61 patients. Ezetimibe added to statin therapy significantly reduced the LDL-C level and TC level by additional 20.1% and 19.1%, respectively (P<0.05). 74% (45/61) patients treated with ezetimibe added to statin reached their target LDL-C goal. No change of TG and HDL-C was observed and no change of AST, ALT and CK was found either.


CONCLUSIONS
Ezetimibe added to statin therapy lowered LDL-C level further and improved the goal attainment in patients with CHD and DM.
Cheng
Shu-Juan
SJ
Beijing Anzhen Hospital Affiliated to the Capital University of Medical Science, Beijing, China.
Yan
Hong-Bing
HB
Ma
Qin
Q
Xu
Fang-Xing
FX
D000410:Alanine Transaminase / Q000097:blood; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D001219:Aspartate Aminotransferases / Q000097:blood; D001384:Azetidines / Q000627:therapeutic use*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000150:complications*; D003402:Creatine Kinase / Q000097:blood; D048909:Diabetes Complications / Q000097:blood*; D004359:Drug Therapy, Combination; D000069438:Ezetimibe; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D000924:Anticholesteremic Agents; D001384:Azetidines; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D000069438:Ezetimibe