title: Infectious mononucleosis hepatitis in young adults: two case reports.
abstract: Infectious mononucleosis due to Epstein-Barr virus (EBV) infection sometimes causes acute hepatitis, which is usually self-limiting with mildly elevated transaminases, but rarely with jaundice. Primary EBV infection in children is usually asymptomatic, but in a small number of healthy individuals, typically young adults, EBV infection results in a clinical syndrome of infectious mononucleosis with hepatitis, with typical symptoms of fever, pharyngitis, lymphadenopathy, and hepatosplenomegaly. EBV is rather uncommonly confirmed as an etiologic agent of acute hepatitis in adults. Here, we report two cases: the first case with acute hepatitis secondary to infectious mononucleosis and a second case, with acute hepatitis secondary to infectious mononucleosis concomitantly infected with hepatitis A. Both cases involved young adults presenting with fever, pharyngitis, lymphadenopathy, hepatosplenomegaly, and atypical lymphocytosis confirmed by serologic tests, liver biopsy and electron microscopic study.
authors: Department of Internal Medicine, Clinical Research Institute, Ewha Womans University School of Medicine, Seoul, Korea.
authors: Min-Jung
authors: MJ
authors: Kang
authors: Tae-Hun
authors: TH
authors: Kim
authors: Ki-Nam
authors: KN
authors: Shim
authors: Sung-Ae
authors: SA
authors: Jung
authors: Min-Sun
authors: MS
authors: Cho
authors: Kwon
authors: K
authors: Yoo
authors: Kyu Won
authors: KW
authors: Chung
mesh_terms: D000208:Acute Disease; D000328:Adult; D018414:CD8-Positive T-Lymphocytes / Q000821:virology; D005260:Female; D006505:Hepatitis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications*; D008099:Liver / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D055815:Young Adult