title: [Expression and significance of CD147 protein in prostate cancer].
abstract: OBJECTIVE
  To investigate the expression of CD147 in prostate cancer and discuss its diagnostic value in prostate cancer.
  
  
  METHODS
  The method of immunohistochemical SP was employed to detect the expression of CD147 in 101 cases of prostate cancer, 90 cases of benign prostatic hyperplasia, 36 cases of normal prostate and 15 cases of embryonic prostate by so as to evaluate its clinical significance in the histological classification and prognosis of prostate cancer.
  
  
  RESULTS
  The CD147 expression was positively expressed in 67/101 (66.3%) of prostate cancer, 21/90 (23.3%) of benign prostatic hypertrophy, 2/36 (5.6%) of normal prostate and 0/15 (0.0) of embryonic prostate respectively. A positive expression of CD147 was dramatically associated with TNM stage (P < 0.001), the depth of prostatic capsule invasion (P = 0.002) and histological grade (P = 0.006).
  
  
  CONCLUSIONS
  The detection of CD147 is helpful to raise the early diagnosis rate of prostate cancer. It will become a tumor marker of reflecting the malignant degree and predicting the prognosis of prostate cancer.
authors: Department of Urology, First Municipal People's Hospital Affiliated to Guangzhou Medical College, Guangzhou 510182, China.
authors: Hui-Chan
authors: HC
authors: He
authors: Zhao-Dong
authors: ZD
authors: Han
authors: Qi-Shan
authors: QS
authors: Dai
authors: Jun
authors: J
authors: Zou
authors: Yang
authors: Y
authors: Zhang
authors: Zheng
authors: Z
authors: Zhang
authors: Yu-Xiang
authors: YX
authors: Liang
authors: Yong-Kang
authors: YK
authors: Ye
authors: Zhi-Nan
authors: ZN
authors: Chen
authors: Wei-De
authors: WD
authors: Zhong
mesh_terms: D000368:Aged; D051926:Basigin / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D011467:Prostate / Q000378:metabolism* / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D051926:Basigin