Controlling reactive oxygen species in skin at their source to reduce skin aging.
Activity of an age-related, superoxide-forming, cell-surface oxidase (arNOX) comparing dermis, epidermis, serum, and saliva from female and male subjects ages 28-72 years measured spectrophotometrically using reduction of ferricytochrome c correlated with oxidative skin damage as estimated from autofluoresence of skin using an Advanced Glycation End products Reader (AGE-Reader; DiagnOptics B.V., Netherlands). By reducing arNOX activity in skin with arNOX-inhibitory ingredients (NuSkin's ageLOC technology), skin appearance was improved through decreased protein cross-linking and an accelerated increase in collagen.
Kern
Dale G
DG
Nu Skin International, Provo, Utah 84601, USA.
Draelos
Zoe D
ZD
Meadows
Christiaan
C
James Morré
D
D
Morré
Dorothy M
DM
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood / Q000378:metabolism* / Q000502:physiology* / Q000652:urine; D001592:Benzyl Alcohols / Q000494:pharmacology; D016922:Cellular Senescence / Q000187:drug effects / Q000502:physiology; D004311:Double-Blind Method; D015536:Down-Regulation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D005960:Glucosides; D006801:Humans; D008297:Male; D008875:Middle Aged; D009247:NADH, NADPH Oxidoreductases / Q000032:analysis / Q000037:antagonists & inhibitors / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010919:Placebos; D011506:Proteins / Q000032:analysis / Q000378:metabolism; D016032:Randomized Controlled Trials as Topic; D017382:Reactive Oxygen Species / Q000097:blood / Q000378:metabolism* / Q000652:urine; D012463:Saliva / Q000378:metabolism; D012867:Skin / Q000378:metabolism*; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000494:pharmacology
D001592:Benzyl Alcohols; D004791:Enzyme Inhibitors; D005960:Glucosides; D010919:Placebos; D011506:Proteins; D017382:Reactive Oxygen Species; D014451:Ubiquinone; C005696:salicin; D009247:NADH, NADPH Oxidoreductases; C431909:tumor-associated NADH oxidase; C024989:coenzyme Q10