title: [Automated synthesis of 2-[(18)F]-fluoro-2-deoxy-D-glucose by on-column hydrolysis].
abstract: OBJECTIVE
  To study automated synthesis of 2-[(18)F]-fluoro-2-deoxy-D-glucose ((18)F-FDG) via on-column hydrolysis.
  
  
  METHODS
  Automated synthesis of (18)F-FDG was performed by the on-column hydrolysis procedure in TRACERlab FXF-N synthesizer. (18)F-FDG injection was obtained via nucleophilic fluorination of 1, 3, 4, 6-tetra-O-acetyl-2-O-trifluoromethanesulfony-beta-D-mannopyranose as the precursor molecule with (18)F-fluoride, hydrolysis of the (18)F-labeled intermediate on SEP-PAK C18 cartridges with 2 mol/L NaOH solution, and purification and neutralization with SEP-PAK cartridges.
  
  
  RESULTS
  The uncorrected radiochemical yield of (18)F-FDG was more than 60% within the total synthesis time shorter than 20 min. The radiochemical purity of (18)F-FDG was above 99%.
  
  
  CONCLUSIONS
  On-column hydrolysis is simple and practical for the automated synthesis of (18)F-FDG. (18)F-FDG injection produced by this procedure can be used in clinical PET imaging.
authors: PET-CT Centre, Hunan Tumour Hospital, Changsha 410013,China.
authors: Lei
authors: L
authors: Luo
authors: Ganghua
authors: G
authors: Tang
authors: Xiaolan
authors: X
authors: Tang
mesh_terms: D000328:Adult; D000368:Aged; D001331:Automation / Q000379:methods; D019788:Fluorodeoxyglucose F18 / Q000138:chemical synthesis*; D006801:Humans; D006868:Hydrolysis; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000000981:diagnostic imaging; D008297:Male; D049268:Positron-Emission Tomography; D011859:Radiography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18