Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective.
The origins of the adaptive immune system and the basis for its unique association with vertebrate species have been a source of considerable speculation. In light of recent advances in our understanding of the developmental and functional links between the induced regulatory T cell and T helper 17 cell lineages, and their specialized relationship to the gut, we speculate that the co-evolution of these adaptive immune pathways might have given primitive vertebrates a means to benefit from the diversification of their commensal microbiota.
Weaver
Casey T
CT
Department of Pathology, BBRB 870, University Station, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. cweaver@uab.edu
Hatton
Robin D
RD
D056704:Adaptive Immunity / Q000276:immunology*; D000818:Animals; D005075:Biological Evolution; D019070:Cell Lineage / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D020381:Interleukin-17