Neuroprotection in the newborn infant.
Neonatal brain injury is an important cause of death and disability, with pathways of oxidant stress, inflammation, and excitotoxicity that lead to damage that progresses over a long period of time. Therapies have classically targeted individual pathways during early phases of injury, but more recent therapies such as growth factors may also enhance cell proliferation, differentiation, and migration over time. More recent evidence suggests combined therapy may optimize repair, decreasing cell injury while increasing newly born cells.
Gonzalez
Fernando F
FF
Department of Pediatrics, University of California, 521 Parnassus Avenue, C215, Box 0663, San Francisco, CA 94143, USA.
Ferriero
Donna M
DM
D000975:Antioxidants / Q000627:therapeutic use*; D001930:Brain Injuries / Q000628:therapy*; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D007231:Infant, Newborn; D055495:Neurogenesis / Q000502:physiology*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D033581:Stem Cell Transplantation / Q000379:methods*; D016896:Treatment Outcome
D000975:Antioxidants; D018696:Neuroprotective Agents