Particulate antigen induced immune activation influences steroidogenesis in murine lymphoid organs with parallel increase in circulating IL-6.
The effect of sheep red blood cells (SRBC), live Escherichia coli cells administration and interleukin-6 (IL-6) treatment on steroidogenesis in murine lymphoid organs with concomitant changes in serum IL-6 levels were studied in the male Swiss albino mice. From the lymphoid tissue homogenate, the activities of 3betaHSD, 17betaHSD, corticosterone, testosterone and IL-6 levels of serum were estimated. The 3betaHSD activity in murine lymphoid organs, as well as the IL-6 levels in serum increased after administration of SRBC and live E. coli cells, as compared to control. Whereas the 17betaHSD activity was decreased in the murine lymphoid organs with a concomitant reduced serum testosterone level was found after particulate antigen administration or IL-6 treatment. The serum corticosterone and serum IL-6 level were also elevated.
Mukhopadhyay
Rupanjan
R
Immunology Laboratory, Department of Physiology, University of Calcutta, University Colleges of Science and Technology, 92 A.P.C. Road, Kolkata 700 009, India.
Bishayi
Biswadev
B
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D004912:Erythrocytes / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology*; D015850:Interleukin-6 / Q000008:administration & dosage / Q000097:blood*; D008208:Lymphatic System / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D012756:Sheep
D015850:Interleukin-6; D015096:3-Hydroxysteroid Dehydrogenases; D003345:Corticosterone