Patch-basis electrocortical source imaging in epilepsy.
In this study, we developed numerical methods for investigating the sources of epileptic activity from intracranial EEG recordings acquired from intracranial subdural electrodes (iEEG) in patients undergoing pre-surgical evaluation at the epilepsy center of the Mayo Clinic (Rochester, MN). The data were analyzed using independent component analysis (ICA), which identifies and isolates maximally independent signal components in multi-channel recordings. A realistic individual head model was constructed for a patient undergoing pre-surgical evaluation. Structural models of gray matter, white matter, CSF, skull, and scalp were extracted from pre-surgical MR and post-surgical CT images. The electromagnetic source localization forward problem was solved using the Boundary Element Method (BEM). Source localization was performed using the Sparse Bayesian Learning (SBL) algorithm. The multiscale patch-basis source space constructed for this purpose includes a large number of dipole elements on the cortical layer oriented perpendicular to the local cortical surface. These source dipoles are combined into overlapping multi-scalepatches. Using this approach, we were able to detect seizure activity on sulcal walls and on gyrus of the cortex.
Acar
Zeynep Akalin
ZA
Swartz Center for Computational Neuroscience, Institute for Neural Computation, University of California San Diego, La Jolla, CA, USA. [zeynep,scott]@sccn.ucsd.edu
Worrell
Gregory
G
Makeig
Scott
S
D000465:Algorithms; D001499:Bayes Theorem; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000378:metabolism; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016011:Normal Distribution; D018408:Patch-Clamp Techniques; D025341:Principal Component Analysis; D011827:Radiation; D012640:Seizures / Q000503:physiopathology; D012815:Signal Processing, Computer-Assisted; D014057:Tomography, X-Ray Computed