[Sporotrichosis and dematiaceous fungal skin infections].
Sporotrichosis is a chronic infectious granuloma of skin. The detection of fungal elements in pathological examination and the isolation of Sporothrix schenckii from the lesion are requisite for diagnosis. The sporotrichin test is useful as an auxiliary examination, but a false-negative reaction might occur in some cases. Oral potassium iodide is first choice of treatment, because of its modest cost and usefulness, although gastrointestinal disorder is a frequent side effect. Itraconazole should be the second selection, and then terbinafine. Local thermotherapy is also effective as an additional therapy. Dematiaceous fungal skin infections are divided into two groups by their parasitic form, chromoblastomycosis and phaeohyphomycosis. Chromoblastomycosis is also called chromomycosis in Japan. It is most important for clinical diagnosis to detect dark brown spores in the scale of chromoblastomycosis and dark brown hyphae in the pus of phaeohyphomycosis by microscopic examination. Both morphological and molecular biological approaches are recommended for identification of fungi. In treatment, the drug appropriate in each case should be selected, and the combination of surgical excision, local thermotherapy, laser therapy or cryotherapy must be considered.
Kusuhara
Masahiro
M
KUSUHARA Dermatology Clinic.
D000284:Administration, Oral; D002862:Chromoblastomycosis / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy*; D003131:Combined Modality Therapy; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008853:Microscopy; D009281:Naphthalenes / Q000627:therapeutic use; D011193:Potassium Iodide / Q000008:administration & dosage / Q000009:adverse effects; D013175:Sporothrix / Q000302:isolation & purification / Q000648:ultrastructure; D013174:Sporotrichosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D000077291:Terbinafine
D009281:Naphthalenes; D011193:Potassium Iodide; D017964:Itraconazole; D000077291:Terbinafine