title: Illness during pregnancy and bacterial vaginosis are associated with in-utero HIV-1 transmission.
abstract: HIV-1 transmission in utero accounts for 20-30% of vertical transmission events in breast-feeding populations. In a prospective study of 463 HIV-1-infected mothers and infants, illness during pregnancy was associated with 2.6-fold increased risk of in-utero HIV-1 transmission [95% confidence interval (CI) 1.2-5.8] and bacterial vaginosis with a three-fold increase (95% CI 1.0-7.0) after adjusting for maternal HIV-1 viral load. Interventions targeting these novel risk factors could lead to more effective prevention of transmission during pregnancy.
authors: Department of Medicine, University of Washington, 325 Ninth Avenue, Box 359909, Seattle, WA 98104, USA. cfarq@u.washington.edu
authors: Carey
authors: C
authors: Farquhar
authors: Dorothy
authors: D
authors: Mbori-Ngacha
authors: Julie
authors: J
authors: Overbaugh
authors: Dalton
authors: D
authors: Wamalwa
authors: Jennifer
authors: J
authors: Harris
authors: Rose
authors: R
authors: Bosire
authors: Grace
authors: G
authors: John-Stewart
mesh_terms: D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000635:transmission*; D015497:HIV-1; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D007630:Kenya / Q000453:epidemiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012307:Risk Factors; D016585:Vaginosis, Bacterial / Q000150:complications* / Q000453:epidemiology*