Proliferation and tumor suppression: not mutually exclusive for Eph receptors.
Eph receptors are important but controversial regulators of cancer development. A recent study reported in Cell reveals that in the intestinal epithelium, EphB2 enhances proliferation through a kinase-dependent pathway and inhibits migration independent of its kinase activity. These separate pathways simultaneously promote proliferation but suppress invasive growth of intestinal adenomas.
Noberini
Roberta
R
Burnham Institute for Medical Research, La Jolla, CA 92037, USA.
Pasquale
Elena B
EB
D000236:Adenoma / Q000473:pathology*; D000818:Animals; D049109:Cell Proliferation; D006801:Humans; D007414:Intestinal Neoplasms / Q000473:pathology*; D051379:Mice; D018345:Mice, Knockout; D036183:Receptor, EphB2 / Q000502:physiology*
D036183:Receptor, EphB2