title: Human papillomavirus in rare unilateral benign intranasal tumours.
abstract: BACKGROUND
  Inverted papilloma (IP), oncocytic papilloma (OP), respiratory epithelial adenomatoid hamartoma (REAH) and capillary hemangioma (CH) are benign and rare tumours. OP and IP are associated with squamous cell carcinoma (SCC). Human papillomavirus (HPV) may play a role in malignant transformation.
  
  
  OBJECTIVE
  We aimed to investigate the presence of HPV, inflammation, epithelial dysplasia, and prognostic markers including proliferative cell nuclear antigen (PCNA), epidermal growth fac- tor receptor (EGFR) and p53 in tissue specimens from rare unilateral intranasal benign tumours.
  
  
  METHODS
  Presence of HPV DNA was detected by PCR. Proliferative cell nuclear antigen, EGFR, p53 expression and the presence of HPV type 16 in tissues were determined by immuno-histochemical analysis.
  
  
  RESULTS
  We determined the presence of HPV DNA in 2 of 6 IP cases, in one CH patient and one OP patient, but the REAH patient was negative. Histologically, only one specimen with IP was positive for HPV type 16 being the high risk type. The remaining cases were considered as low risk type HPV.
  
  
  CONCLUSIONS
  Although our patient numbers are limited, there is a significant association between IP and HPV. This is the first study showing the cooccurrence of CH and OP with HPV.
authors: Department of Microbiology and Clinical Microbiology, School of Medicine, Adnan Menderes University, Aydin, Turkey.
authors: Sevin
authors: S
authors: Kirdar
authors: Sema
authors: S
authors: Basak
authors: Onur
authors: O
authors: Odobasi
authors: Furuzan Kacar
authors: FK
authors: Doger
authors: Gokhan
authors: G
authors: Erpek
mesh_terms: D000328:Adult; D000368:Aged; D052685:Alphapapillomavirus / Q000302:isolation & purification* / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D004279:DNA, Viral / Q000032:analysis; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D018324:Hemangioma, Capillary / Q000821:virology*; D052162:Human papillomavirus 16 / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000821:virology; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D004279:DNA, Viral; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53; C512478:EGFR protein, human; D066246:ErbB Receptors