GLI1 genotypes do not predict basal cell carcinoma risk: a case control study.
BACKGROUND
Susceptibility to basal cell carcinoma results from complex interactions between ultraviolet radiation exposure and genetic factors. The GLI1 oncogene is believed to play a role in the genesis of these tumors. We determined whether GLI1 polymorphisms were risk factors for developing basal cell carcinoma, either alone or in combination with patterns of past sun exposure, and whether there were functional differences among different GLI1 haplotypes.


RESULTS
GLI1 genotypes at c.2798 and c.3298 from 201 basal cell carcinoma patients were compared to 201 age and sex-matched controls. Neither genotype nor haplotype frequencies differed between cases and controls. However, the odds of developing basal cell carcinoma on the trunk compared to the head/neck appeared somewhat lower with carriers of the c.3298GC than the CC genotype. There was no evidence for interactions between skin type, childhood sunburning, average adult sun exposure, adult sunbathing, or intermittency of sun exposure and GLI1 haplotype. Additionally, we found no significant differences in transcription activation or cell transforming ability among the four GLI1 haplotypes.


CONCLUSIONS
These results suggest that different GLI1 genotypes alone or in combination with past sun exposure patterns as assessed in this study do not affect basal cell carcinoma risk.
Watson
Andrea
A
1Department of Pediatrics, University of Minnesota - Duluth, Minnesota, USA. Awatson1@smdc.org
Kent
Paul
P
Alam
Murad
M
Paller
Amy S
AS
Umbach
David M
DM
Yoon
Joon Won
JW
Iannaccone
Philip M
PM
Walterhouse
David O
DO
D000328:Adult; D000368:Aged; D002280:Basal Cell Carcinoma / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics*; D013472:Sunlight; D014157:Transcription Factors / Q000235:genetics*; D055815:Young Adult; D000071676:Zinc Finger Protein GLI1
C400551:GLI1 protein, human; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1