[Dynamic observation of applying repairing laryngeal mucosal defect with heterogeneous acellular dermal matrix].
OBJECTIVE
To study the clinical effect of heterogeneity (cattle) acellular dunal matrix in repairing mucosa defect in laryngeal surgery.


METHODS
Eighteen cancer patients with mucosa defect in central vocal area accepted treatment with heterogeneity acellular dunal matrix after surgery. There were two methods to repair mucosa defect. One was simple use of acellular dunal matrix, the second was combined use of acellular dunal matrix and muscle lamella or muscle and tendon film lamella. 18 cases had cancer in central vocal area: T2N0M0 (8), T3N1M0 (5), T3N2M0 (4), T4N2M0 (1). All were squamous cell carcinoma. Ten cancer patients accepted radiation after surgery. The radiotherapy volume was 60-80 Gy. After the operation, the patients were checked by fibrolaryngoscope four or five times after half a year, observing the dynamic development.


RESULTS
All 18 patients were healed, rechecked by endoscope after 0.5-6 months, heterogeneity acellular dunal matrix mingled with mucosa within 30-60 d, no allergy and irritation were found. The laryngeal function, including breathing, pronouncing and swallowing, was recovered. The survival rate (1 year) was 100%, and 10 patients survived after 2 years. After radiotherapy, the process of recovery was not affected.


CONCLUSIONS
Heterogeneity acellular dunal matrix can be easily obtained and it is a new method to repair mucosa defect. The operative procedure is easy to perform and worthwhile to use clinically.
Zhang
Qing-Quan
QQ
Department of Otorhinolaryngology Head and Neck Surgery, Yuhuangding Hospital of Medical School of Qingdao University, Yantai 264000, China. ytebhzqq@163.com
Sun
Yan
Y
Song
Xi-Cheng
XC
Zhang
Hua
H
Wang
Qiang
Q
Wang
Xi-Wen
XW
Zhu
Yu-Hong
YH
Chen
Xiu-Mei
XM
Jiang
Shao-Hong
SH
D000328:Adult; D000368:Aged; D000818:Animals; D001672:Biocompatible Materials; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D002417:Cattle; D020405:Dermis / Q000166:cytology*; D005260:Female; D006801:Humans; D007820:Laryngeal Mucosa / Q000473:pathology*; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D014945:Wound Healing
D001672:Biocompatible Materials