Bone mineral density in children with steroid-sensitive nephrotic syndrome.
OBJECTIVE
To observe the influence of prednisolone treatment on bone mineral density (BMD) in children with idiopathic nephrotic syndrome.


METHODS
Duel-energy X-ray absorptiometry of lumbar spine (L1-L4) was performed on 40 patients (18 first episode and 22 relapsers) of steroid sensitive idiopathic nephrotic syndrome.


RESULTS
Patients of first episode and relapsers had comparable values of mean age, weight, height, body mass index, serum calcium, phosphate, spine area, bone mineral content (BMC) and BMD. Relapsing nephrotic syndrome patients received significantly higher mean total cumulative dose of prednisolone in comparison to first episode (p<0.001). The BMD Z-scores were normal in 39 of 40 (97.5%) patients. On regression analysis, it was found that both BMC and BMD did not correlate with cumulative dose of prednisolone, when other co-variants such as age, weight, height and spine area were adjusted.


CONCLUSIONS
Bone mineral density in steroid sensitive nephrotic syndrome is unaffected by cumulative dose of prednisolone therapy both in first episode as well as relapser group of patients.
Mishra
O P
OP
Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. opmpedia@yahoo.co.uk
Meena
S K
SK
Singh
S K
SK
Prasad
R
R
Mishra
R N
RN
D015502:Absorptiometry, Photon; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D018488:Bone Demineralization, Pathologic / Q000139:chemically induced* / Q000209:etiology; D015519:Bone Density / Q000187:drug effects*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D012008:Recurrence; D012044:Regression Analysis
D000893:Anti-Inflammatory Agents; D011239:Prednisolone