Evaluation of the anti-stress and anticonvulsant activities of leaf extract of Alchornea cordifolia in mice.
OBJECTIVE
The extract of the leaves of Alchornea cordifolia (AC) is extensively used in ethnomedicine for ulcers, rheumatic pains, febrile convulsions and for enhancing physical performance. In this study, the anti-stress and anticonvulsant activities of the aqueous leaf extract of Alchornea cordifolia were investigated in mice.


METHODS
The anti-stress activity was assessed based on the ability of the extract to alter the duration of immobility, in the forced swim endurance test, whilst a picrotoxin-treated animal, was employed as the model for convulsive seizures.


RESULTS
The extract (100-400 mg/kg) given orally was found to significantly (p<0.05) reduce the duration of immobility, which suggest an anti-stress/anti-fatigue property. However, AC when tested at doses between 100 and 400 mg/kg did not prevent convulsions induced by picrotoxin in mice. The acute toxicity study carried out in mice revealed that the extract was well tolerated by the animals, as no death was observed at oral doses of 500-4000 mg/kg.


CONCLUSIONS
The results of this preliminary study provide evidence, which may support the use of Alchornea cordifolia against stress or fatigue in ethnomedicine.
Umukoro
Solomon
S
Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria. umusolo@yahoo.com
Aladeokin
Aderemi Caleb
AC
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D019665:Euphorbiaceae / Q000737:chemistry*; D005221:Fatigue / Q000188:drug therapy*; D005260:Female; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010852:Picrotoxin; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D013315:Stress, Psychological / Q000188:drug therapy*; D013550:Swimming
D000927:Anticonvulsants; D010852:Picrotoxin; D010936:Plant Extracts