Hypoxic-ischemic encephalopathy in the term infant.
Hypoxia-ischemia in the perinatal period is an important cause of cerebral palsy and associated disabilities in children. There has been significant research progress in hypoxic-ischemic encephalopathy over the last 2 decades, and many new molecular mechanisms have been identified. Despite all these advances, therapeutic interventions are still limited. In this article the authors discuss several molecular pathways involved in hypoxia-ischemia, and potential therapeutic targets.
Fatemi
Ali
A
Kennedy Krieger Institute, Department of Neurology, Johns Hopkins Medical Institutions, 707 N Broadway, Baltimore, MD 21205, USA.
Wilson
Mary Ann
MA
Johnston
Michael V
MV
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D017209:Apoptosis; D002547:Cerebral Palsy / Q000209:etiology* / Q000517:prevention & control; D003952:Diagnostic Imaging; D019988:Children with Disabilities; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods; D020925:Hypoxia-Ischemia, Brain / Q000150:complications / Q000378:metabolism / Q000628:therapy; D007231:Infant, Newborn; D018384:Oxidative Stress / Q000502:physiology; D011379:Prognosis
D000975:Antioxidants