title: [Severe hypercalcemia complicated in acute lymphoblastic leukemia (ALL) with E2A-HLF fusion gene: report of two cases and literature review].
abstract: OBJECTIVE
  To improve the understanding of severe hypercalcemia complicated in acute lymphoblastic leukemia (ALL) with E2A-HLF fusion gene, and to explore the mechanism of pathogenesis and the relationship between the special gene translocation and severe hypercalcemia.
  
  
  METHODS
  Two patients with severe hypercalcemia complicated in ALL were reported.
  
  
  RESULTS
  Two patients with E2A-HLF fusion gene, which is generated by t(17;19) (q22, p13) translocation, suffered relapse of leukemia three months after chemotherapy, and developed severe hypercalcemia. After further chemotherapy, the hypercalcemia symptoms were corrected or alleviated.
  
  
  CONCLUSIONS
  Severe hypercalcemia is one of rare complications of ALL. In B cell lymphoblastic leukemia with E2A-HLF fusion gene, the fusion gene showed be closely monitored for evaluating the disease situation.
authors: The Hematology Center of Beijing Children Hospital, Capital Medical University, Beijing 100045, China.
authors: Jun
authors: J
authors: Yang
authors: Xuan
authors: X
authors: Zhou
authors: Bin
authors: B
authors: Wang
authors: Chao
authors: C
authors: Gao
authors: Rui-dong
authors: RD
authors: Zhang
authors: Bin
authors: B
authors: Li
mesh_terms: D002648:Child; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology* / Q000235:genetics; D007223:Infant; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000235:genetics*; D011379:Prognosis; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C076554:E2a-Hlf fusion protein, human; D015514:Oncogene Proteins, Fusion; D014157:Transcription Factors