[Key problems in using ultrasonic cavitating bubble as a gene or drug vector].
Ultrasound, serveing as an oscillating source, can induce cavitation in liquids; and the bubble produced in this process is a very promising kind of vector for gene delivery and drug target release, owing to its unique properties. This article involves the cavitation mechanism, the control over sonoporation, and the influence of ultrasound contrast agent. The status quo of research and the challenges encountered are discussed. This overview is devoted to providing a theoretical basis for clinical use of cavitating bubble vector.
Zhang
Yiwei
Y
State Key Laboratory of Hydroscience and Engineering, Tsinghua University, Beijing 100084, China.
Chen
Tiejun
T
Lin
Shuhong
S
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D045423:Microbubbles; D014464:Ultrasonic Therapy / Q000379:methods; D014465:Ultrasonics
D003287:Contrast Media; D008081:Liposomes