title: Fibrin clot properties in acute ischemic stroke: relation to neurological deficit.
abstract: BACKGROUND
  Hypercoagulable state occurs in patients with acute vascular events. We wondered whether clot structure/function is altered in acute ischemic stroke (AIS), like in acute myocardial infarction.
  
  
  METHODS
  In 45 consecutive patients with AIS (24M, 21F), aged 67.4+/-10.9 years, and 45 healthy controls matched for age and sex, we investigated plasma fibrin clot structure/function by permeation, turbidity, and efficiency of fibrinolysis.
  
  
  RESULTS
  Compared to controls, AIS patients produced clots that had 30.5% less porous network (p<0.0001), were less susceptible to fibrinolysis (10.8% longer lysis time, p=0.001), were 20.5% more compact (p<0.0001), had 17.1% higher clot mass (p<0.0001), and showed increased (by 10.2%) overall fiber thickness (p<0.0001) with 8% shorter lag phase of fibrin formation (p=0.0002). Maximum rate of D-dimer release from clots was similar. Multiple regression analyses for all subjects (n=90) showed that being a stroke patient (p<0.0001), fibrinogen (p<0.0001) and lipoprotein(a) (p=0.0075) were independent predictors of clot permeability (model R2 0.79). Only fibrinogen (p<0.0001) and lipoprotein(a) (p=0.0026) predicted lysis time. All other fibrin parameters were predicted only by being a stroke patient. Clot compaction was associated with neurological deficit on admission (r=-0.81; p<0.0001) and at discharge (r=-0.69; p<0.0001). Patients with 0 or 1 point in the modified Rankin scale (n=19) had 13.3% higher clot permeability compared to the remainder (p=0.02).
  
  
  CONCLUSIONS
  This study is the first to show that AIS is associated with unfavorably altered fibrin clot properties that might correlate with neurological deficit.
authors: Institute of Cardiology, Jagiellonian University School of Medicine, Cracow, Poland. mmundas@cyf-kr.edu.pl
authors: Anetta
authors: A
authors: Undas
authors: Agnieszka
authors: A
authors: Slowik
authors: Pawel
authors: P
authors: Wolkow
authors: Andrzej
authors: A
authors: Szczudlik
authors: Wiesława
authors: W
authors: Tracz
mesh_terms: D000208:Acute Disease; D000368:Aged; D001780:Blood Coagulation Tests; D005190:Family; D005260:Female; D005337:Fibrin / Q000378:metabolism*; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000235:genetics; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D020767:Intracranial Thrombosis; D007511:Ischemia; D008297:Male; D008875:Middle Aged; D010539:Permeability; D020521:Stroke / Q000097:blood*; D013927:Thrombosis / Q000097:blood
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D005337:Fibrin; D005340:Fibrinogen