title: Effect of meal ingestion on ileocolonic and colonic transit in health and irritable bowel syndrome.
abstract: BACKGROUND
  Postprandial symptoms in irritable bowel syndrome (IBS) have been associated with increased bowel contractility.
  
  
  OBJECTIVE
  To compare ileocolonic and colonic responses to feeding in health and IBS.
  
  
  METHODS
  We prospectively analyzed data from separate research trials in 122 IBS patients and 41 healthy volunteers. Ileocolonic transit (ICT) was evaluated before (colonic filling [CF]3h) and immediately after (CF4 h) a standard lunch at 3 h 45 min, and 2 h thereafter. The colonic geometric center (GC) was calculated 2 h (GC6 h) after lunch ingested at 4 h (GC4 h) and directly after (GC8 h) a standard dinner ingested at 7 h 45 min.
  
  
  RESULTS
  ICT immediately after eating was higher in IBS diarrhea predominant (IBS-D) patients than in the healthy cohort (23.1 +/- 2.4 vs. 17.5 +/- 2.8%, P = 0.059). ICT 2 h after lunch was similar between groups (P = 0.55). There was significant overall group differences in colonic transit 2 h post-lunch (P = 0.045), particularly in the IBS constipation predominant (IBS-C; GC6-GC4, delta 0.29 +/- 0.08) patients versus healthy volunteers (delta 0.56 +/- 0.12 GC units).
  
  
  CONCLUSIONS
  After feeding, ICT is increased in IBS-D, whereas colonic transit is blunted in IBS-C.
authors: Clinical Enteric Neuroscience Translational and Epidemiological Research, College of Medicine, Mayo Clinic, Charlton 8-110, 200 First St SW, Rochester, MN 55905, USA.
authors: Annemie
authors: A
authors: Deiteren
authors: Michael
authors: M
authors: Camilleri
authors: Duane
authors: D
authors: Burton
authors: Sanna
authors: S
authors: McKinzie
authors: Archana
authors: A
authors: Rao
authors: Alan R
authors: AR
authors: Zinsmeister
mesh_terms: D000284:Administration, Oral; D000328:Adult; D003106:Colon / Q000502:physiology*; D004435:Eating / Q000502:physiology*; D005260:Female; D005502:Food; D005772:Gastrointestinal Transit / Q000502:physiology*; D006801:Humans; D007082:Ileum / Q000502:physiology*; D043183:Irritable Bowel Syndrome / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D011877:Radionuclide Imaging; D012016:Reference Values; D013667:Technetium / Q000008:administration & dosage
chemical_list: D013667:Technetium