Prompt-gamma compensation in Rb-82 myocardial perfusion 3D PET/CT.
OBJECTIVE
To compare the diagnostic accuracy of Rb-82 myocardial perfusion three-dimensional (3D) PET with and without prompt-gamma compensation (PGC).


RESULTS
Retrospective, single center study of 76 patients who had rest and adenosine stress Rb-82 myocardial perfusion 3D PET. All studies were acquired using a Siemens Biograph-40 PET/CT scanner and were reconstructed with and without PGC. Fifty-seven patients (mean age 63 +/- 11 years, 26 men) had coronary angiography within 40 days of Rb-82 imaging. Nineteen patients (mean age 43 +/- 7 years, 10 men) had low likelihood of coronary artery disease (CAD). All PET images were scored by consensus of two blinded readers on a standard 5-point scale using a 17-segment left ventricular model. A normal PET test was defined as a summed stress score of less than four. Obstructive CAD at coronary angiography was used as the gold-standard and was defined as luminal stenoses > or =50% in one or more major coronary arteries. The prevalence of obstructive disease at coronary angiography was 68% (39/57). The mean summed stress score was 12 +/- 12 for PGC images and was 18 +/- 14 for non-PGC images. Sensitivity and specificity for obstructive CAD were 90% (95% CI 88-99) and 72% (95% CI 52-93) for PGC images and 95% (95% CI 88-100) and 22% (95% CI 3-41) for non-PGC images.


CONCLUSIONS
PGC in Rb-82 3D PET improves the specificity for obstructive CAD at coronary angiography with no significant loss in sensitivity.
Esteves
Fabio P
FP
Department of Radiology, Emory University School of Medicine, 1364 Clifton Road, NE, Atlanta, GA 30322, USA. festeve@emory.edu
Nye
Jonathan A
JA
Khan
Akbar
A
Folks
Russell D
RD
Halkar
Raghuveer K
RK
Garcia
Ernest V
EV
Schuster
David M
DM
Lerakis
Stamatios
S
Raggi
Paolo
P
Votaw
John R
JR
D000328:Adult; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000000981:diagnostic imaging; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D010477:Perfusion; D049268:Positron-Emission Tomography / Q000379:methods*; D012189:Retrospective Studies; D012414:Rubidium Radioisotopes / Q000737:chemistry; D012542:Scattering, Radiation; D014057:Tomography, X-Ray Computed / Q000379:methods*
D012414:Rubidium Radioisotopes