title: Pharmacogenomic adaptation of antiretroviral therapy: overcoming the failure of lopinavir in an African infant with CYP2D6 ultrarapid metabolism.
authors: Matthias
authors: M
authors: Gorny
authors: Stephanie
authors: S
authors: Röhm
authors: Stephanie
authors: S
authors: Läer
authors: Nezihe
authors: N
authors: Morali
authors: Tim
authors: T
authors: Niehues
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D044383:Black People; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism*; D065690:Cytochrome P-450 CYP2D6 Inhibitors; D004347:Drug Interactions; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007223:Infant; D061466:Lopinavir; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D011744:Pyrimidinones / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D019438:Ritonavir / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D017211:Treatment Failure
chemical_list: D065690:Cytochrome P-450 CYP2D6 Inhibitors; D011744:Pyrimidinones; D061466:Lopinavir; D019389:Cytochrome P-450 CYP2D6; D019438:Ritonavir