Induction of abortion with aglepristone in cats on day 45 and 46 after mating.
The aim of this study was to test for the efficacy and safety of the use of aglepristone for pregnancy termination on day 45 in cats. Six healthy cats were treated with 10 mg/kg aglepristone sc on day 45 and 46 after mating; six other cats served as untreated controls. The effect of treatment was monitored by general examination, vaginal cytology, ultrasonography and blood sampling for haematology and progesterone determination. Besides, interoestrus interval and next pregnancy including litter size were recorded. The efficacy of treatment was approximately 67% (4/6) with abortion occurring 4-7 days after the first injection and a sanguineous discharge and erythrocytes in vaginal smears for at least 6 days afterwards. The two treated cats that did not abort gave birth to two kittens on day 67 and had a stillbirth of a single kitten on day 71, respectively. As expected enlargement of the mammary glands and lactation were observed in all treated cats. No other treatment-induced side effects were observed. Progesterone levels at abortion were high (30-140 nmol/l), but were decreased on day 55. Aglepristone treatment did not affect fertility in following cycles. Finally, it can be concluded that late-term pregnancy termination with aglepristone is possible but due to a success rate of 67% an ultrasonographical examination 7 days after treatment is an inherent necessity to control the effect of treatment.
Georgiev
P
P
Clinic for Obstetrics, Reproduction and Reproductive Disorders of Veterinary Faculty of the Trakian University, Stara Zagora, Bulgaria.
Bostedt
H
H
Goericke-Pesch
S
S
Dimitrov
M
M
Petkov
P
P
Stojanthev
K
K
Tsoneva
V
V
Wehrend
A
A
D000019:Abortifacient Agents / Q000627:therapeutic use*; D000034:Abortion, Veterinary / Q000139:chemically induced*; D000818:Animals; D002415:Cats; D004963:Estrenes / Q000627:therapeutic use*; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D013997:Time Factors; D014621:Vagina / Q000166:cytology
D000019:Abortifacient Agents; D004963:Estrenes; C419063:aglepristone; D011374:Progesterone