Socio-psychological impact of infused iron chelation therapy with deferoxamine in metropolitan France: ISOSFER study results.
Deferoxamine (DFO) is an iron chelator used to treat iron overload in patients receiving chronic blood transfusions, and is usually administered as overnight subcutaneous infusions. ISOSFER was a prospective, observational, cross-sectional study conducted in metropolitan France that evaluated patient characteristics, quality of life (QoL), compliance and patient satisfaction with DFO monotherapy. Of 70 patients with either thalassemia, sickle cell disease or myelodysplastic syndromes, 30% were 'satisfied' or 'very satisfied' with DFO. Patients' SF-36 scores were lower than those of the general French population, and lower among patients with comorbidities and those dissatisfied with treatment. Although 72% of patients had good compliance to DFO, 57% reported missing at least one infusion in the previous month, and 82% of patients expressed a preference for oral therapy. These results suggest that QoL is severely compromised in patients receiving DFO, and that compliance is not optimal.
Thuret
Isabelle
I
CHU Timone, Marseille, France. isabelle.thuret@mail.ap-hm.fr
Hacini
Maya
M
Pégourié-Bandelier
Brigitte
B
Gardembas-Pain
Martine
M
Bisot-Locard
Ségolène
S
Merlat-Guitard
Annabelle
A
Bachir
Dora
D
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001803:Blood Transfusion / Q000523:psychology; D015913:Chelation Therapy / Q000009:adverse effects / Q000523:psychology*; D002648:Child; D003430:Cross-Sectional Studies; D003676:Deferoxamine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005602:France; D006402:Hematologic Diseases / Q000523:psychology / Q000628:therapy; D006801:Humans; D019190:Iron Overload / Q000188:drug therapy / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011446:Prospective Studies; D011788:Quality of Life; D017262:Siderophores / Q000009:adverse effects / Q000627:therapeutic use*; D065227:Transfusion Reaction
D017262:Siderophores; D003676:Deferoxamine