[Effect of volemic status on brain oxygenation and metabolism in patients with intracranial hemorrhages].
The paper analyzes the impact of the volemic status and its correction on systemic hemodynamic parameters (transpulmonary thermodilution PiCCO plus technique), the value of intracranial pressure and the biochemical composition of brain interstitial fluid (tissue microdialysis) in the affected and conditionally intact hemisphere in 8 patients with intracranial hemorrhages and a reduced awakening level up to 4-8 scores by the Glasgow coma scale. It has been shown that in patients with significant metabolic disturbance in the involved hemisphere, hypovolemia correction using hydroxyethyl starch 130/0.4 is accompanied by activated oxidative phosphorylation and a lower lactate/pyruvate ratio, without changing the of blood pressure and increasing pulmonary extravascular water.
Petrikov
S S
SS
Titova
Iu V
IuV
Guseĭnova
Kh T
KhT
Solodov
A A
AA
Krylov
V V
VV
D000328:Adult; D001921:Brain / Q000378:metabolism*; D045604:Extracellular Fluid / Q000378:metabolism; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage / Q000627:therapeutic use; D020896:Hypovolemia / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D020300:Intracranial Hemorrhages / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D007427:Intracranial Pressure; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D010952:Plasma Substitutes / Q000008:administration & dosage / Q000627:therapeutic use; D019289:Pyruvic Acid / Q000378:metabolism
C485123:HES 130-0.4; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D019344:Lactic Acid; D019289:Pyruvic Acid; D010100:Oxygen