CD8(+)HLA-G(+) regulatory T cells are expanded in HIV-1-infected patients.
It has been recently reported that CD8(+) T cells from healthy human peripheral blood express the tolerogenic HLA-G molecule originally described in trophoblasts. The majority of these CD8(+)HLA-G(+) cells exhibit a naïve phenotype and are FoxP3 negative, and they have been classified as a novel subset of regulatory T cells based on their potent suppressive function. We have investigated if this new cell population is expanded during HIV-1 infection. The results presented here show an increase in the percentage of CD8(+)HLA-G(+) cells within the total CD8 T-cell population in HIV-1(+) patients. As in healthy controls, these CD8(+)HLA-G(+) are mostly naïve T cells. However, we have also observed that only in HIV-1-infected patients are there effector and effector memory cells that express HLA-G.
Lozano
Jose Manuel
JM
Servicio de Inmunología, Hospital Reina Sofía, 14004 Córdoba, Spain. fi1pemaj@uco.es
González
Rafael
R
Luque
Juan
J
Frias
Mario
M
Rivero
Antonio
A
Peña
Jose
J
D023241:Antiretroviral Therapy, Highly Active; D016827:CD8 Antigens / Q000032:analysis; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D051858:Forkhead Transcription Factors / Q000032:analysis; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D015497:HIV-1; D006680:HLA Antigens / Q000032:analysis; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D006801:Humans; D007108:Immune Tolerance; D016130:Immunophenotyping; D018655:Lymphocyte Count; D016176:T-Lymphocyte Subsets / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D019562:Viral Load
D016827:CD8 Antigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I