Dunaliella as an attractive candidate for molecular farming.
Pharmaceutical recombinant proteins are widely used in human healthcare. At present, several protein expression systems are available to generate therapeutic proteins. These conventional systems have distinct advantages and disadvantages in protein yielding; in terms of ease of manipulation, the time required from gene transformation to protein purification, cost of production and scaling-up capitalization, proper folding and stability of active proteins. Depending on the research goal and priorities, a special system may be selected for protein expression. However, considering the limited variety of organisms currently used and their usage restrictions, there are still much more pharmaceutical proteins waiting to be economically and efficiently produced. Distinguished biological and technical features of microalgae Dunaliella such as inexpensive medium requirement, fast growth rate, the ease of manipulation, easy scaling up procedure, facility of milking in bioreactors and the ability of post-translational modifications make this microorganism an attractive candidate for molecular farming.
Barzegari
Abolfazl
A
Department of Food Biotechnology, Branch of West and North-West Region of Iran (Tabriz), Agricultural Biotechnology Research Institute of Iran, Karaj, Iran. Tabriz.biotechnology@gmail.com
Hejazi
Mohammad Amin
MA
Hosseinzadeh
Nahid
N
Eslami
Solat
S
Mehdizadeh Aghdam
Elnaz
E
Hejazi
Mohammad Saeid
MS
D015870:Gene Expression; D058086:Microalgae / Q000378:metabolism*; D058634:Molecular Farming / Q000379:methods*