title: Association of anti-Helicobacter pylori neutrophil-activating protein antibody response with anti-aquaporin-4 autoimmunity in Japanese patients with multiple sclerosis and neuromyelitis optica.
abstract: There are two distinct subtypes of multiple sclerosis (MS) in Asians: opticospinal (OSMS) and conventional (CMS). OSMS has similar features to neuromyelitis optica (NMO) and half of OSMS patients have the NMO-Immunoglobulin G (IgG)/ anti-aquaporin-4 (AQP4) antibody. We reported that Helicobacter pylori (H. pylori) infection was significantly less common in CMS patients than controls. To reveal the immune responses to the H. pylori neutrophil-activating protein (HP-NAP) in Japanese MS patients, according to anti-AQP4 antibody status, sera from 162 MS patients, 37 patients with other inflammatory neurological diseases (OIND), and 85 healthy subjects were assayed for anti-H. pylori antibodies, anti-HP-NAP antibodies, and myeloperoxidase (MPO) by enzyme immunoassays. H. pylori seropositivity rates were significantly higher in anti-AQP4 antibody-positive MS/NMO (AQP4 + /MS) patients (19/27, 70.4%) than anti-AQP4 antibody-negative CMS (AQP4 - /CMS) patients (22/83, 26.5%). Among H. pylori-infected individuals, the anti-HP-NAP antibody was significantly more common in AQP4 + /MS and AQP4 - /OSMS patients than healthy subjects (36.8%, 34.6% versus 2.8%). Among the AQP4 + /MS patients, a significant positive correlation between anti-HP-NAP antibody levels and the final Kurtzke's Expanded Disability Status Scale scores was found, and MPO levels were higher in anti-HP-NAP antibody-positive patients than anti-HP-NAP antibody-negative ones. Therefore, HP-NAP may be associated with the pathology of anti-AQP4 antibody-related neural damage in MS/NMO patients.
authors: Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
authors: Wei
authors: W
authors: Li
authors: Motozumi
authors: M
authors: Minohara
authors: Hua
authors: H
authors: Piao
authors: Takuya
authors: T
authors: Matsushita
authors: Katsuhisa
authors: K
authors: Masaki
authors: Takeshi
authors: T
authors: Matsuoka
authors: Noriko
authors: N
authors: Isobe
authors: Jen Jen
authors: JJ
authors: Su
authors: Yasumasa
authors: Y
authors: Ohyagi
authors: Jun-ichi
authors: J
authors: Kira
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D051401:Aquaporin 4 / Q000276:immunology*; D044466:Asian People; D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity; D001426:Bacterial Proteins / Q000276:immunology*; D004185:Disability Evaluation; D005260:Female; D016481:Helicobacter Infections / Q000208:ethnology / Q000276:immunology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000208:ethnology / Q000276:immunology* / Q000382:microbiology / Q000628:therapy; D009471:Neuromyelitis Optica / Q000208:ethnology / Q000276:immunology* / Q000382:microbiology / Q000628:therapy; D009195:Peroxidase / Q000097:blood; D015995:Prevalence; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: C496030:AQP4 protein, human; D000907:Antibodies, Bacterial; D051401:Aquaporin 4; D001323:Autoantibodies; D001426:Bacterial Proteins; C092412:neutrophil-activating protein A, Helicobacter pylori; D009195:Peroxidase