title: Assessment of serum N-terminal pro-B-type natriuretic peptide concentration for differentiation of congestive heart failure from primary respiratory tract disease as the cause of respiratory signs in dogs.
abstract: OBJECTIVE
  To determine whether serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration is useful in discriminating between cardiac and noncardiac (ie, primary respiratory tract disease) causes of respiratory signs (ie, coughing, stertor, stridor, excessive panting, increased respiratory effort, tachypnea, or overt respiratory distress) in dogs.
  
  
  METHODS
  Multicenter cross-sectional study.
  
  
  METHODS
  P 115 dogs with respiratory signs.
  
  
  METHODS
  Dogs with respiratory signs were solicited for study. Physical examination, thoracic radiography, and echocardiography were used to determine whether respiratory signs were the result of cardiac (ie, congestive heart failure) or noncardiac (ie, primary respiratory tract disease) causes. Serum samples for NT-proBNP assay were obtained at time of admission for each dog. Receiver-operating characteristic curves were constructed to determine the ability of serum NT-proBNP concentration to discriminate between cardiac and noncardiac causes of respiratory signs.
  
  
  RESULTS
  Serum NT-proBNP concentration was significantly higher in dogs with cardiac versus noncardiac causes of respiratory signs. In dogs with primary respiratory tract disease, serum NT-proBNP concentration was significantly higher in those with concurrent pulmonary hypertension than in those without. A serum NT-proBNP cutoff concentration > 1,158 pmol/L discriminated between dogs with congestive heart failure and dogs with primary respiratory tract disease with a sensitivity of 85.5% and a specificity of 81.3%.
  
  
  CONCLUSIONS
  Measuring serum NT-proBNP concentration in dogs with respiratory signs helps to differentiate between congestive heart failure and primary respiratory tract disease as an underlying cause.
authors: Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. maoyama@vet.upenn.edu
authors: Mark A
authors: MA
authors: Oyama
authors: John E
authors: JE
authors: Rush
authors: Elizabeth A
authors: EA
authors: Rozanski
authors: Philip R
authors: PR
authors: Fox
authors: Caryn A
authors: CA
authors: Reynolds
authors: Sonya G
authors: SG
authors: Gordon
authors: Barret J
authors: BJ
authors: Bulmer
authors: Bonnie K
authors: BK
authors: Lefbom
authors: Bill A
authors: BA
authors: Brown
authors: Linda B
authors: LB
authors: Lehmkuhl
authors: Robert
authors: R
authors: Prosek
authors: Michael B
authors: MB
authors: Lesser
authors: Marc S
authors: MS
authors: Kraus
authors: Maribeth J
authors: MJ
authors: Bossbaly
authors: Gregg S
authors: GS
authors: Rapoport
authors: Jean-Sebastien
authors: JS
authors: Boileau
mesh_terms: D000818:Animals; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis*; D004285:Dogs; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012140:Respiratory Tract Diseases / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D012680:Sensitivity and Specificity
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain