title: [Effects of heroin and purine nucleotide compensation on neutral alpha-glucosidase in rat epididymides].
abstract: OBJECTIVE
  To study the changes of neutral alpha-glucoside activity in the epididymis of heroin-dependent and heroin-withdrawal rats, and to investigate the effects of intervention with purine nucleotide (AMP and GMP).
  
  
  METHODS
  Eighty Wistar rats were randomly divided into 8 groups of equal number, control, nucleotide, heroin, heroin + nucleotide, 3 d withdrawal, 9 d withdrawal, 3 d nucleotide (nucleotide administrated for 3 days after heroin withdrawal) and 9 d nucleotide (nucleotide administrated for 9 days after heroin withdrawal). Neutral alpha-glucosidase activity in the epididymis was detected in each group of rats.
  
  
  RESULTS
  Compared with the control group, neutral alpha-glucoside activity was markedly decreased in the heroin group (P < 0.05), and also in the 3 d and 9 d withdrawal groups, although with no significant differences (P > 0.05).
  
  
  CONCLUSIONS
  Heroin reduces neutral alpha-glucoside activity in the epididymis of rats, and this effect may continue for some time after drug withdrawal, while purine nucleotide can keep neutral alpha-glucosidase activity in a relatively stable state.
authors: Department of Histology and Embryology, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin 130021, China. cuijiayue@jlu.edu.cn
authors: Jia-yue
authors: JY
authors: Cui
authors: Jia-ying
authors: JY
authors: Zhang
authors: Wen-jing
authors: WJ
authors: Zuo
authors: Zhong-shan
authors: ZS
authors: Wang
authors: Min
authors: M
authors: Hong
mesh_terms: D000818:Animals; D004822:Epididymis / Q000737:chemistry*; D003932:Heroin / Q000009:adverse effects*; D006556:Heroin Dependence / Q000378:metabolism*; D008297:Male; D011685:Purine Nucleotides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000520:alpha-Glucosidases / Q000378:metabolism*
chemical_list: D011685:Purine Nucleotides; D003932:Heroin; D000520:alpha-Glucosidases