Low coherence interferometer for sensing retardance change during neural activity.
A variety of optical measurements, including retardance/birefringence change, have revealed transient optical and structural changes associated with action potential propagation. Those changes can be understood better by developing new techniques and improving the current approaches. To detect transient retardance changes in a stimulated nerve, we propose a differential phase technique utilizing two orthogonal polarization channels of a polarization-maintaining fiber based interferometer. The superior sensitivity of the system (10.4 pm) is promising to achieve a non-contact optical measurement of action potential propagation in reflection mode, and to study the transient retardance changes during neural activity.
Al-Kaisi
Muhammad K
MK
Department of Biomedical Engineering, University of Minnesota, Twin Cities, MN 55455, USA. alkai002@umn.edu
Landowne
David
D
Akkin
Taner
T
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation / Q000295:instrumentation*; D004566:Electrodes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D017859:Esocidae; D005336:Fiber Optic Technology / Q000295:instrumentation; D066298:In Vitro Techniques; D007368:Interferometry / Q000295:instrumentation*; D009832:Olfactory Nerve / Q000502:physiology*; D010783:Photometry / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D009435:Synaptic Transmission / Q000502:physiology*