title: Modeling cerebral blood flow and regulation.
abstract: Cerebral autoregulation is a homeostatic mechanism which maintains blood flow despite changes in blood pressure in order to meet local metabolic demands. Several mechanisms play a role in cerebral autoregulation in order to adjust vascular tone and caliber of the cerebral vessels, but the exact etiology of the dynamics of these mechanism is not well understood. In this study, we discuss two patient specific models predicting cerebral blood flow velocity during postural change from sitting to standing. One model characterises cerebral autoregulation, the other describes the beat-to-beat distribution of blood flow to the major regions of the brain. Both models have been validated against experimental data from a healthy young subject.
authors: Biomathematics Program, North Carolina State University, Raleigh, NC 26795, USA. mcaoi@ncsu.edu
authors: Mikio
authors: M
authors: Aoi
authors: Pierre
authors: P
authors: Gremaud
authors: Hien T
authors: HT
authors: Tran
authors: Vera
authors: V
authors: Novak
authors: Mette S
authors: MS
authors: Olufsen
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D002536:Cerebral Arteries / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003198:Computer Simulation; D025461:Feedback, Physiological / Q000502:physiology*; D006801:Humans; D008954:Models, Biological