Development of an oxazole conjunctive reagent and application to the total synthesis of siphonazoles.
The preparation of 4-carbethoxy-5-methyl-2-(phenylsulfonyl)methyloxazole and its use in the elaboration of more complex oxazoles are described. A total synthesis of the unique natural products siphonazoles A and B, illustrates an application of this building block. A discussion of the biological activity of the siphonazoles is also presented.
Zhang
Jianmin
J
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver BC V6T 1Z1, Canada.
Polishchuk
Elena A
EA
Chen
Jie
J
Ciufolini
Marco A
MA
D001688:Biological Products / Q000138:chemical synthesis; D007202:Indicators and Reagents; D008722:Methods; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry
D001688:Biological Products; D007202:Indicators and Reagents; D010080:Oxazoles; C520719:siphonazole