Selective micro preconcentration of propofol for anesthetic depth monitoring by using seedless electroplated gold as adsorbent.
This communication presents selective preconcentration of the anesthetic agent (Propofol) and the elimination of unwanted species from a representative sample of human breath. In this approach, a micro preconcentrator (microPC) consisting of embedded high-aspect-ratio pillars (30 microm x 120 microm chi 240 microm), an outer dimensions of 7 mm x 7 mm (encompass more than 3500 micro pillars), total inner surface area of approximately 10 m(2), and a total inner volume of approximately 6.5 microL was used to selectively preconcentrate Propofol. The microPC has on-chip thermal desorption capability and was coated by electrodeposited gold as an adsorbent material. Experimental evaluations showed successful preconcentration of trace level of Propofol from a mixture containing several volatile organic compounds diluted in water-like solvent (1-propanol) and the efficient removal of non-polar compounds present in the mixture.
Alfeeli
Bassam
B
VTMEMS Laboratory, Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. alfeeli@vt.edu
Zareian-Jahromi
Mohammad A
MA
Agah
Masoud
M
D000433:1-Propanol / Q000737:chemistry; D000327:Adsorption; D000777:Anesthetics / Q000494:pharmacology*; D004595:Electroplating; D018274:Electroporation; D004867:Equipment Design; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D008904:Miniaturization; D016343:Monitoring, Intraoperative / Q000295:instrumentation* / Q000379:methods; D055095:Optics and Photonics; D015742:Propofol / Q000494:pharmacology*; D012997:Solvents / Q000737:chemistry; D013499:Surface Properties
D000777:Anesthetics; D012997:Solvents; D006046:Gold; D000433:1-Propanol; D015742:Propofol