Targeting polyamines and biogenic amines by green tea epigallocatechin-3-gallate.
Biogenic amines and polyamines are organic polycations derived from aromatic or cationic amino acids. They exert pleiotropic effects, more related to intercellular communication in the case of biogenic amines, and to intracellular signaling in the case of polyamines. The bioactive compound epigallocatechin-3-gallate (EGCG), a major component of green tea, has been shown to target key enzyme of biogenic amine and polyamine metabolic pathways. Herein, we review the specific effects of EGCG on concrete molecular targets of both biogenic amine and polyamine metabolic pathways, and discuss the relevance of these data to support the potential therapeutic interest of this compound.
Melgarejo
Esther
E
Procel Lab, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, 29071 Málaga, Spain.
Urdiales
José Luis
JL
Sánchez-Jiménez
Francisca
F
Medina
Miguel Angel
MA
D000818:Animals; D001679:Biogenic Amines / Q000096:biosynthesis*; D015317:Biogenic Polyamines / Q000096:biosynthesis; D053898:Biosynthetic Pathways / Q000187:drug effects; D028241:Camellia sinensis / Q000737:chemistry*; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D013662:Tea / Q000737:chemistry
D001679:Biogenic Amines; D015317:Biogenic Polyamines; D010936:Plant Extracts; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate