[The influence of immunocorrection on the state of the anti-endotoxin immunity in children with systemic inflammatory response syndrome and gram-negative infection].
There were examined 34 children, in whom systemic inflammatory answer syndrome (SIAS) was diagnosed. In 16 children pathogenetically substantiated immunocorrection, using donor's plasma, enhanced by antibodies (AB) to endotoxin (ET), was conducted; in 18 children--the conventional complex therapy. While presence of gram-negative infection in children, suffering SIAS, the activation o the inborn nonspeciphic factors (LBP, sCD14) and speciphic low-affinic AB (anti-ET-IgM, anti-ET-IgA) the antiendotoxin immunity in combination with selective immunodeficiency of anti-ET-IgG were revealed. While the donor's plasm application, enhanced by AB to ET, the titer of anti-ET-IgG, anti-ET-IgM, anti-ET-IgA and LBP have had achieved normal values and did not differ from such in the control on the 14th day.
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D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D000915:Antibody Affinity; D002648:Child; D004731:Endotoxins / Q000276:immunology*; D016905:Gram-Negative Bacterial Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D010951:Plasma Exchange; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D004731:Endotoxins