title: Administration of copper oxide wire particles in a capsule or feed for gastrointestinal nematode control in goats.
abstract: Widespread anthelmintic resistance in small ruminants has necessitated alternative means of gastrointestinal nematode (GIN) control. The objective was to determine the effectiveness of copper oxide wire particles (COWP) administered as a gelatin capsule or in a feed supplement to control GIN in goats. In four separate experiments, peri-parturient does (n=36), yearling does (n=25), weaned kids (n=72), and yearling bucks (n=16) were randomly assigned to remain untreated or administered 2g COWP in a capsule (in Experiments 1, 2, and 3) or feed supplement (all experiments). Feces and blood were collected every 7 days between Days 0 and 21 (older goats) or Day 42 (kids) for fecal egg counts (FEC) and blood packed cell volume (PCV) analyses. A peri-parturient rise in FEC was evident in the untreated does, but not the COWP-treated does (COWP x date, P<0.02). In yearling does, FEC of the COWP-treated does tended to be lower than the untreated (COWP, P<0.02). FEC of COWP-treated kids were reduced compared with untreated kids (COWP x date, P<0.001). FEC of treated and untreated bucks were similar, but Haemonchus contortus was not the predominant nematode in these goats. However, total worms were reduced in COWP-fed bucks (P<0.03). In summary, it appeared that COWP in the feed was as effective as COWP in a gelatin capsule to reduce FEC in goats. COWP administration may have a limited effect where H. contortus is not the predominant nematode.
authors: Dale Bumpers Small Farms Research Center, USDA, ARS, Booneville, AR 72927, USA. joan.burke@ars.usda.gov
authors: J M
authors: JM
authors: Burke
authors: F
authors: F
authors: Soli
authors: J E
authors: JE
authors: Miller
authors: T H
authors: TH
authors: Terrill
authors: S
authors: S
authors: Wildeus
authors: S A
authors: SA
authors: Shaik
authors: W R
authors: WR
authors: Getz
authors: M
authors: M
authors: Vanguru
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002214:Capsules; D003300:Copper / Q000008:administration & dosage*; D005260:Female; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D015511:Goat Diseases / Q000188:drug therapy* / Q000469:parasitology* / Q000517:prevention & control; D006041:Goats; D008297:Male; D009348:Nematoda; D009349:Nematode Infections / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D011247:Pregnancy
chemical_list: D002214:Capsules; D003300:Copper; C030973:cupric oxide