[The evolutionary role of nitric oxide in circadian activity and defense of the organism from cosmic rays].
The cosmic rays are one of the constantly acting factors influencing on genetic apparatus and depending from sun activity, which have the circadian rhythm. The nature creates a number of mechanisms, which defend the organism from cosmic rays and free radicals as consequence. However, the malfunctions of these mechanisms damage the genetic apparatus, accelerate the aging and bring to a number of illnesses. It is supposed that to neutralise the free radicals as cosmic rays consequence the organism uses its own free radicals, which have the physiological functions, for example, the nitric oxide. To limit the nitric oxide production, the mechanism of melatonin formation is used, which has a circadian rhythm.
Iamshanov
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D000222:Adaptation, Physiological / Q000528:radiation effects*; D000375:Aging / Q000378:metabolism / Q000528:radiation effects; D000818:Animals; D005075:Biological Evolution; D002940:Circadian Rhythm / Q000528:radiation effects*; D003359:Cosmic Radiation / Q000009:adverse effects*; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008550:Melatonin / Q000096:biosynthesis* / Q000097:blood; D009569:Nitric Oxide / Q000096:biosynthesis / Q000502:physiology*
D005609:Free Radicals; D009569:Nitric Oxide; D008550:Melatonin