[An association study of brain-derived neurotrophic factor gene polymorphism in bipolar disorders].
OBJECTIVE
To investigate the association between brain-derived neurotrophic factor (BDNF) gene polymorphism and bipolar disorder.


METHODS
Single nucleotide polymorphisms rs6265 and rs11030101 in BDNF gene were detected and compared between 228 patients with bipolar disorder and 361 healthy controls.


RESULTS
The genotypes, alleles and combinative genotype of BDNF gene single nucleotide polymorphism rs6265 and rs11030101 did not show significant differences between two groups. There were also no significant differences in genotypes and combinative genotypes between diagnostic subtypes, genders and on-set age of bipolar disorder and controls.


CONCLUSIONS
This study did not found that BDNF gene single nucleotide polymorphism rs6265 and rs11030101 are associated with bipolar disorders.
Ye
Chen-yu
CY
Department of Psychiatry, Huashan Hospital, Fudan University, Shanghai 200040, China.
Xu
Ye-qing
YQ
Hu
Hua
H
Yu
Shun-ying
SY
Wang
Dong-xiang
DX
Shi
Shen-xun
SX
Wang
Li-wei
LW
D000328:Adult; D000368:Aged; D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
D019208:Brain-Derived Neurotrophic Factor