Administration of human immunoglobulin suppresses development of murine systemic vasculitis induced with Candida albicans water-soluble fraction: an animal model of Kawasaki disease.
We investigated the inhibitory effect of human immunoglobulin (h-Ig) on the development of coronary arteritis in a murine model of vasculitis induced with a Candida albicans water-soluble fraction (CAWS). CAWS was intraperitoneally injected to C57BL/6 mice for 5 days. Then h-Ig was administered according to various schedules. The animals were sacrificed in week 5, and the status of vasculitis in the coronary arteries and the aortic root was investigated histologically. The groups in which h-Ig was administered for 5 days from day 3 and from day 5 of the experiment showed a significant reduction in the incidence of panvasculitis. In addition, the scope and severity of the inflammation of the aortic root and the coronary arteries were reduced in both groups. In the group administered h-Ig for 5 days from day 1 and the group administered a high dose of h-Ig once on day 1 or day 3, no suppression of development of vasculitis was observed. The h-Ig acted by suppressing the generation and progression of vasculitis in this CAWS-induced murine vasculitis model.
Takahashi
Kei
K
Department of Pathology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro, Tokyo, 153-8515, Japan. keitak@oha.toho-u.ac.jp
Oharaseki
Toshiaki
T
Yokouchi
Yuki
Y
Miura
Noriko N
NN
Ohno
Naohito
N
Okawara
Akiko I
AI
Murata
Hisao
H
Naoe
Shiro
S
Suzuki
Kazuo
K
D000818:Animals; D000946:Antigens, Fungal; D001167:Arteritis / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D002176:Candida albicans; D003324:Coronary Artery Disease / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D004195:Disease Models, Animal; D006801:Humans; D007116:Immunization, Passive; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D009080:Mucocutaneous Lymph Node Syndrome / Q000276:immunology*; D013997:Time Factors
D000946:Antigens, Fungal; D016756:Immunoglobulins, Intravenous