title: Distribution of CCR5-Delta32, CCR5m303A, CCR2-64I and SDF1-3'A in HIV-1 infected and uninfected high-risk Uighurs in Xinjiang, China.
abstract: BACKGROUND
  Genetic variants of the genes encoding HIV-1 co-receptors and their ligands, CCR5-Delta32, CCR5m303A, CCR2-64I and SDF1-3'A, are implicated in the susceptibility to HIV-1 infection, and the prevalence of these mutations varies by ethnicity. However, little is known about their distribution in Uighurs.
  
  
  OBJECTIVE
  This study aimed at characterizing the frequency of these HIV-related gene variants in a high-risk Uighur population.
  
  
  METHODS
  A total of 251 HIV-1 seropositive and 238 seronegative high-risk Uighurs were recruited and their genotypes of CCR5-Delta32, CCR5m303A, CCR2-64I and SDF1-3'A were analyzed by PCR and PCR-ligase detection reaction (PCR-LDR).
  
  
  RESULTS
  The allelic frequency of CCR5-Delta32, CCR5m303A, CCR2-64I and SDF1-3'A was 4.40%, 2.66%, 25.66% and 57.36%, respectively, in this population. Apparently, the Uighur population has low frequency of CCR5-Delta32 and CCR5m303A, but high frequency of CCR2-64I and SDF1-3'A. While there was no significant difference in the frequency of CCR5-Delta32, CCR2-64I and SDF1-3' A between HIV-1 seropositive and seronegative groups the frequency of CCR5m303A in HIV-1 seropositive group was significantly higher than that in seronegative group (P=0.006, OR=3.982 and 95%CI 1.514-10.476).
  
  
  CONCLUSIONS
  Our data suggest that the CCR5-Delta32, CCR2-64I and SDF1-3'A variants may have limited effect on protecting from HIV-1 infection in Uighurs. Rather, the CCR5m303A may be associated with the risk for HIV-1 infection in high-risk Uighurs.
authors: Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University, Xinjiang 832002, PR China.
authors: Xiao-hua
authors: XH
authors: Tan
authors: Jing-yu
authors: JY
authors: Zhang
authors: Chun-hong
authors: CH
authors: Di
authors: Ao-rong
authors: AR
authors: Hu
authors: Lei
authors: L
authors: Yang
authors: Shen
authors: S
authors: Qu
authors: Rong-li
authors: RL
authors: Zhao
authors: Pei-rong
authors: PR
authors: Yang
authors: Shu-xia
authors: SX
authors: Guo
mesh_terms: D000293:Adolescent; D000328:Adult; D054377:Chemokine CXCL12 / Q000235:genetics*; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D015995:Prevalence; D054390:Receptors, CCR2 / Q000235:genetics*; D019713:Receptors, CCR5 / Q000235:genetics*
chemical_list: C515334:CCR2 protein, human; D054377:Chemokine CXCL12; D054390:Receptors, CCR2; D019713:Receptors, CCR5