title: The relationship of pulp polyp with the presence and concentration of immunoglobulin E, histamine, interleukin-4 and interleukin-12.
abstract: The aim of this study was to evaluate the relationship between pulp polyp formation and immunoglobulin E (IgE), histamine and interleukin-4 (IL-4) as the most important mediators which are involved in allergy. Thirty-two samples including 16 pulp polyps and 16 normal pulps were gathered. After homogenising the pulpal tissue samples, enzyme-linked immunosorbent assay (ELISA) techniques were used to assess the concentration of IgE, histamine, IL-4 and IL-12. The two groups showed statistically significant differences in terms of both the concentration and presence of IgE, histamine and IL-4 (P < 0.001); both presence and concentration of IgE, histamine and IL-4 were higher in pulp polyps than in normal pulps. There is not any significant difference between case and control groups regarding IL-12. The results of this study give rise to the possibility of type I hypersensitivity reaction being involved in pulp polyp's pathogenesis.
authors: Department of Immunology, Medical School, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Iran.
authors: Mandana
authors: M
authors: Sattari
authors: Ali K
authors: AK
authors: Haghighi
authors: Hasan D
authors: HD
authors: Tamijani
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D003782:Dental Pulp / Q000276:immunology; D005260:Female; D006632:Histamine / Q000032:analysis*; D006801:Humans; D006965:Hyperplasia; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007073:Immunoglobulin E / Q000032:analysis*; D018664:Interleukin-12 / Q000032:analysis*; D015847:Interleukin-4 / Q000032:analysis*; D008297:Male; D011671:Pulpitis / Q000276:immunology*
chemical_list: D018664:Interleukin-12; D015847:Interleukin-4; D007073:Immunoglobulin E; D006632:Histamine