Liver and kidney transplantation in HIV-infected patients.
HIV infection has evolved into a chronic condition as a result of improvements in therapeutic options. Chronic exposure with HIV and associated co-pathogens as well as toxicities from prolonged therapy with antiviral medications has resulted in increased morbidity and mortality rates from end-stage liver and kidney disease in the HIV-infected population. Since the definitive treatment for end-stage organ failure is transplantation, demand has increased among HIV-infected patients. Although the transplant community has been slow to recognize HIV as a chronic condition, many transplant centers have eliminated HIV infection as a contraindication to transplantation as a result of better patient management and demand. This review examines the current clinical strategies and issues surrounding liver and kidney transplantation in HIV-infected patients.
Tan-Tam
Clara C
CC
Department of Surgery, University of California, San Francisco, CA, USA.
Frassetto
Lynda A
LA
Stock
Peter G
PG
D015658:HIV Infections / Q000150:complications*; D048550:Hepatic Insufficiency / Q000601:surgery*; D006801:Humans; D016030:Kidney Transplantation; D016031:Liver Transplantation; D051437:Renal Insufficiency / Q000601:surgery*