title: Changes in regional blood flow induced by unilateral subthalamic nucleus stimulation in patients with Parkinson's disease.
abstract: Changes in regional cerebral blood flow (rCBF) induced by unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) were investigated in 7 consecutive patients with Parkinson's disease, 4 men and 3 women (mean age 62.3 +/- 8.1 years), who underwent rCBF measurement by N-isopropyl-p-(iodine-123)-iodoamphetamine single photon emission computed tomography at rest before and after unilateral STN DBS preoperatively in the on-drug condition, and postoperatively in the on-drug and on-stimulation condition. Statistical parametric mapping was used to identify significant changes in rCBF from the preoperative to the postoperative conditions. rCBF was increased in the bilateral cingulate cortices and bilateral cerebellar hemispheres. rCBF was decreased in the bilateral medial frontal cortices and left superior temporal cortex. Unilateral STN DBS produced rCBF changes in the bilateral cingulate cortices, cerebellar hemispheres, and medial frontal cortices. These findings indicate that unilateral STN DBS affects rCBF in both hemispheres.
authors: Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi.
authors: Takafumi
authors: T
authors: Tanei
authors: Yasukazu
authors: Y
authors: Kajita
authors: Takashi
authors: T
authors: Nihashi
authors: Yoshiki
authors: Y
authors: Kaneoke
authors: Shigenori
authors: S
authors: Takebayashi
authors: Daisuke
authors: D
authors: Nakatsubo
authors: Toshihiko
authors: T
authors: Wakabayashi
mesh_terms: D000368:Aged; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D002531:Cerebellum / Q000098:blood supply / Q000000981:diagnostic imaging / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006179:Gyrus Cinguli / Q000098:blood supply / Q000000981:diagnostic imaging / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000502:physiology*; D013702:Temporal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging / Q000502:physiology; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D016896:Treatment Outcome; D015854:Up-Regulation / Q000502:physiology
chemical_list: D007457:Iodine Radioisotopes