Cobalt-catalyzed regioselective synthesis of pyrrolidinone derivatives by reductive coupling of nitriles and acrylamides.
A convenient and highly regioselective method for the synthesis of 5-methylenepyrrolidinone derivatives from various nitriles and acrylamides via a cobalt-catalyzed reductive coupling reaction is described. A possible mechanism that involves the formation of a cobaltaazacyclopentene intermediate from nitrile and acrylamide, protonation, keto-amide cyclization, and dehydration is proposed.
Wong
Ying-Chieh
YC
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
Parthasarathy
Kanniyappan
K
Cheng
Chien-Hong
CH