title: Secondary osteosarcoma arising after treatment for childhood hematologic malignancies.
abstract: Secondary osteosarcoma arising after the treatment of hematologic malignancies other than Hodgkin's lymphoma is rare. We report two cases of secondary osteosarcoma arising after treatment for childhood hematologic malignancies (non-Hodgkin's lymphoma and lymphoblastic leukemia). A 10-year-old boy, at the age of 3, was diagnosed with non-Hodgkin's lymphoma. He received chemotherapy, radiation, and bone-marrow transplantation and then was in complete remission. At 6 years, he complained of increasing pain of the right thigh and was diagnosed with osteoblastic osteosarcoma. A 26-year-old man, at the age of 6, was diagnosed as having acute lymphoblastic leukemia (ALL). He received chemotherapy, radiation, and peripheral blood stem cell transplantation (PBSCT). At 11 years after PBSCT, he visited with the complaint of left lumbar swelling. He was diagnosed with chondroblastic osteosarcoma. In both cases alkaline phosphatase (ALP) had already increased prior to the onset of the symptom. We should rule out secondary osteosarcoma at the abnormal elevation of ALP during clinical follow-up of patients after treatment of childhood hematologic malignancies.
authors: Department of Orthopaedic Surgery, Tohoku University School of Medicine, Miyagi, Japan.
authors: Atsushi
authors: A
authors: Okada
authors: Masahito
authors: M
authors: Hatori
authors: Masami
authors: M
authors: Hosaka
authors: Munenori
authors: M
authors: Watanuki
authors: Eiji
authors: E
authors: Itoi
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D001859:Bone Neoplasms / Q000175:diagnosis / Q000201:enzymology / Q000209:etiology*; D002648:Child; D019337:Hematologic Neoplasms / Q000628:therapy*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000628:therapy; D008297:Male; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000201:enzymology / Q000209:etiology*; D012516:Osteosarcoma / Q000175:diagnosis / Q000201:enzymology / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D000469:Alkaline Phosphatase