title: Effect of a titration polysomnogram on treatment success with a mandibular repositioning appliance.
abstract: OBJECTIVE
  Mandibular repositioning appliance (MRA) therapy is a treatment option for patients with mild to moderate sleep apnea and for patients who do not tolerate continuous positive airway pressure. Titration of MRAs consists of sequential mandibular advancement guided by symptom improvement. The goal of the study was to determine if patients with an elevated apnea hypopnea index (AHI), despite the use of a subjectively optimized MRA, could achieve better results with additional titration during polysomnography (PSG).
  
  
  METHODS
  Patients were enrolled if they had an AHI > or = 15/h and were referred for MRA therapy. The MRAwas advanced until symptoms improved. During the PSG, the technologist monitored the patient's sleep and increased mandibular protrusion until the AHI was improved.
  
  
  RESULTS
  There was a significant improvement in AHI, minimum oxygen saturation, and total sleep time with the MRA before further advancement. At the final PSG, 65.2% of patients had an AHI < or = 10 associated with at least a 50% reduction in AHI. The incomplete responders had their appliance further titrated, and this improved the results of MRA therapy by 30.4% to a total success rate of 95.6%.
  
  
  CONCLUSIONS
  This study shows that it is possible to improve the results of MRA therapy by further advancing the appliance during a titration PSG in patients with an incomplete response. The titration night improved the results of the usual clinical advancement of the MRA with substantially more patients achieving a successful outcome.
authors: Faculty of Dentistry, The University of British Columbia, Vancouver, BC, Canada. falmeida@interchange.ubc.ca
authors: Fernanda R
authors: FR
authors: Almeida
authors: Jonathan A
authors: JA
authors: Parker
authors: James S
authors: JS
authors: Hodges
authors: Alan A
authors: AA
authors: Lowe
authors: Kathleen A
authors: KA
authors: Ferguson
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D019186:Mandibular Advancement / Q000295:instrumentation* / Q000379:methods*; D008875:Middle Aged; D009968:Orthodontic Appliances, Removable; D010100:Oxygen / Q000378:metabolism; D017286:Polysomnography / Q000379:methods* / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000534:rehabilitation*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D010100:Oxygen