title: Poisson mixture model for measurements using counting.
abstract: Starting with the basic Poisson statistical model of a counting measurement process, 'extraPoisson' variance or 'overdispersion' are included by assuming that the Poisson parameter representing the mean number of counts itself comes from another distribution. The Poisson parameter is assumed to be given by the quantity of interest in the inference process multiplied by a lognormally distributed normalising coefficient plus an additional lognormal background that might be correlated with the normalising coefficient (shared uncertainty). The example of lognormal environmental background in uranium urine data is discussed. An additional uncorrelated background is also included. The uncorrelated background is estimated from a background count measurement using Bayesian arguments. The rather complex formulas are validated using Monte Carlo. An analytical expression is obtained for the probability distribution of gross counts coming from the uncorrelated background, which allows straightforward calculation of a classical decision level in the form of a gross-count alarm point with a desired false-positive rate. The main purpose of this paper is to derive formulas for exact likelihood calculations in the case of various kinds of backgrounds.
authors: Los Alamos National Laboratory, Los Alamos, NM, USA. guthrie@lanl.gov
authors: Guthrie
authors: G
authors: Miller
authors: Alan
authors: A
authors: Justus
authors: Vadim
authors: V
authors: Vostrotin
authors: Donald
authors: D
authors: Dry
authors: Luiz
authors: L
authors: Bertelli
mesh_terms: D000465:Algorithms; D004781:Environmental Exposure; D005189:False Positive Reactions; D006801:Humans; D016013:Likelihood Functions; D008954:Models, Biological; D008962:Models, Theoretical; D009010:Monte Carlo Method; D016012:Poisson Distribution; D011874:Radiometry / Q000592:standards*; D014501:Uranium / Q000652:urine*
chemical_list: D014501:Uranium