title: Cardiac arrest after intracisternal papaverine instillation during intracranial aneurysm surgery. Case report.
abstract: Cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage is still a leading cause of morbidity and death. This 50-year-old man underwent surgery for aneurysm clipping. After the aneurysm was clipped, papaverine was instilled into the surgical area. Bradycardia, hypotension, and sinus arrest developed in the first minute after applying the papaverine. Thus, the authors concluded that the application of papaverine to the surgical area can result in fatal bradycardia and hypotension.
authors: Department of Anaesthesiology and Reanimation, Ankara Training and Research Hospital, Ministry of Health, Ankara, Turkey.
authors: Bulent
authors: B
authors: Baltaci
authors: Hulya
authors: H
authors: Basar
authors: Ayse
authors: A
authors: Ozcan
authors: Yusuf
authors: Y
authors: Gulhan
authors: Cihan Sedat
authors: CS
authors: Aytunur
mesh_terms: D001919:Bradycardia / Q000139:chemically induced; D002946:Cisterna Magna; D017809:Fatal Outcome; D015600:Glasgow Coma Scale; D006323:Heart Arrest / Q000139:chemically induced*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007267:Injections; D002532:Intracranial Aneurysm / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010208:Papaverine / Q000008:administration & dosage* / Q000009:adverse effects*; D054138:Sinus Arrest, Cardiac / Q000139:chemically induced; D013345:Subarachnoid Hemorrhage / Q000601:surgery; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects*
chemical_list: D014665:Vasodilator Agents; D010208:Papaverine