CTX-M beta-lactamase production and virulence of Escherichia coli K1.
We report a patient with neonatal meningitis caused by a CTX-M-1-producing Escherichia coli K1 strain. The influence of CTX-M production on virulence was investigated in cell culture and a newborn mouse model of meningitis. CTX-M production had no influence on virulence but was a major factor in clinical outcome.
Dubois
Damien
D
University of Auvergne, Clermont-Ferrand F-63001, France.
Prasadarao
Nemani V
NV
Mittal
Rahul
R
Bret
Laurent
L
Roujou-Gris
Marie
M
Bonnet
Richard
R
D000328:Adult; D000818:Animals; D004926:Escherichia coli / Q000201:enzymology* / Q000472:pathogenicity; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016920:Meningitis, Bacterial / Q000209:etiology*; D051379:Mice; D011247:Pregnancy; D014774:Virulence; D001618:beta-Lactamases / Q000096:biosynthesis*
C055184:beta-lactamase TEM-3; D001618:beta-Lactamases