title: [The modulating effect of the horn extract from the saiga of different age on the organothypic lymphoid tissue culture].
abstract: The horn extracts from the saiga of different age were used to investigate its effect on organotypic tissue culture of explants from the rat spleen. From 4 to 10 amino acids were detected in the different extract fractions. The horn extracts from the young saiga, at the effective concentration 1 ng/ml, showed stimulating effect in spleen tissue cultures as compared to the control explants. No effect of extracts from the old saiga was observed in tissue culture. Possibly, a stimulation of the cellular proliferation is due to the great amino acid content in saiga horn; however this phenomenon is decreased by the aging.
authors: N I
authors: NI
authors: Chalisova
authors: O E
authors: OE
authors: Romanov
authors: P Iu
authors: PIu
authors: Morozova
authors: N A
authors: NA
authors: Balykina
authors: V V
authors: VV
authors: Lesniak
authors: Iu A
authors: IuA
authors: Sukhonos
authors: A N
authors: AN
authors: Zhekalov
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D006733:Horns / Q000737:chemistry* / Q000254:growth & development; D009924:Organ Culture Techniques; D051381:Rats; D017208:Rats, Wistar; D012418:Ruminants / Q000254:growth & development*; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D014020:Tissue Extracts / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D014020:Tissue Extracts