Hypoxic-ischemic brain injury in neonatal piglets with different histological outcomes: An amplitude-integrated EEG study.
To test the reliability of amplitude-integrated electroencephalogram (aEEG) in cerebral hypoxic ischemia (HI), 12 neonatal piglets subjected to different levels of HI are divided into three groups based on the histological outcomes obtained 4 days after experiment. Results show that concomitant with the increased severity of brain injury, the upper and lower margins of aEEG decrease significantly (p < 0.05) during early recovery period after HI (about 2 hours post-resuscitation). We conclude that aEEG method reliably reflects hypoxic-ischemic cerebral injury and constitutes a valuable monitoring tool in neonatal intensive care unit (NICU).
Zhang
Dandan
D
Department of Biomedical Engineering, Tsinghua University, Beijing, 100084 China. zhangdd05@gmail.com
Hathi
Manan
M
Yang
Zeng-Jin
ZJ
Ding
Haiyan
H
Koehler
Raymond
R
Thakor
Nitish
N
D000818:Animals; D000831:Animals, Newborn; D001238:Asphyxia Neonatorum / Q000175:diagnosis; D001698:Biomedical Engineering; D001930:Brain Injuries / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D007231:Infant, Newborn; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D013552:Swine