Noninvasive three-dimensional cardiac activation imaging on a rabbit model.
Three-dimensional cardiac activation imaging (3-DCAI) aims at imaging the activation sequence throughout the 3-D myocardium. In the present study, the performance of 3-DCAI was validated through both in vivo animal experiments and computer simulations under a pacing protocol. The non-invasively imaged activation sequence from body surface potential maps (BSPMs) was quantitatively compared with the measured activation sequence obtained from the simultaneous intramural recording using a 3-D intra-cardiac mapping technique in a rabbit model. In addition, computer simulations were conducted to provide further assessment of the performance of the 3-DCAI algorithm in a realistic-geometry rabbit heart-torso model. The encouraging results suggest that 3-DCAI can non-invasively image the activation sequence and localize the origin of activation with good accuracy.
Han
Chengzong
C
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA. hanxx158@umn.edu
Liu
Chenguang
C
Pogwizd
Steven
S
He
Bin
B
D000465:Algorithms; D000818:Animals; D001703:Biophysics / Q000379:methods; D018780:Body Surface Potential Mapping / Q000379:methods; D003198:Computer Simulation; D003952:Diagnostic Imaging / Q000379:methods; D006321:Heart / Q000502:physiology*; D006329:Heart Conduction System / Q000502:physiology; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008953:Models, Anatomic; D009206:Myocardium / Q000473:pathology; D011817:Rabbits; D015203:Reproducibility of Results