Simultaneous determination of rabeprazole sodium and itopride hydrochloride in capsule dosage form by spectrophotometry.
Three methods viz. Absorbance Ratio Method (I), Dual Wavelength Method (II) and First Order Derivative Spectroscopic Method (III) for simultaneous estimation of Rabeprazole sodium and Itopride hydrochloride have been developed. The drugs obey Beer's law in the concentration range 2-20 microg/ml for RAB and 5-75 microg/ml for ITO. The results of analysis of drugs have been validated statistically and by recovery studies.
Sabnis
Shweta S
SS
Department of Pharmaceutical Analysis, A.I.S.S.M.S. College of Pharmacy, Kennedy Road, Near R.T.O., Pune - 411 001.
Gandhi
Santosh V
SV
Madgulkar
A R
AR
Bothara
K G
KG
D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000032:analysis*; D000897:Anti-Ulcer Agents / Q000032:analysis; D001549:Benzamides / Q000032:analysis*; D001593:Benzyl Compounds / Q000032:analysis*; D002214:Capsules; D004338:Drug Combinations; D005765:Gastrointestinal Agents / Q000032:analysis; D054328:Proton Pump Inhibitors / Q000032:analysis; D064750:Rabeprazole; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D001549:Benzamides; D001593:Benzyl Compounds; D002214:Capsules; D004338:Drug Combinations; D005765:Gastrointestinal Agents; D054328:Proton Pump Inhibitors; D064750:Rabeprazole; C102254:itopride