[Thromboelastographic characteristics of different infusion therapy regimens in healthy bone marrow donors].
Infusion solutions are able to change the hemostatic system. Thromboelastography (TEG) is an integral technique to evaluate the hemostatic system. TEG was used to evaluate the effect of three infusion solutions (6% hydroxyexyethyl starch (HES) 200/0.5 - Hemohes; HES 130/0.4 - Voluven; modified gelatin solution - Gelofusin) on the hemostatic system in 36 bone marrow donors (healthy individuals). The solutions were used in combination with crystalloid solutions during a procedure to compensate for intraoperative blood loss. Hemostatic changes were noted by the end of an operation in all groups; however, these were less pronounced when Voluven was administered. Thus, all colloid infusion solutions have varying effects on the hemostatic system, with a tendency toward both hypo- and hypercoagulation. According to TEG, HES 130/0.4 (Voluven) has a minimal effect on the hemostatic system.
Bulanov
A Iu
AIu
Shulutko
E M
EM
Shcherbakova
O V
OV
Liubimova
L S
LS
Zhelnova
E I
EI
D000328:Adult; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001853:Bone Marrow; D000077324:Crystalloid Solutions; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage; D008297:Male; D010952:Plasma Substitutes / Q000008:administration & dosage*; D011446:Prospective Studies; D013916:Thrombelastography / Q000379:methods*; D014019:Tissue Donors
D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D010952:Plasma Substitutes