title: Enantioselective total synthesis of (-)-(S)-stepholidine.
abstract: Enantioselective total synthesis of (-)-(S)-stepholidine, a drug candidate for the treatment of schizophrenia and/or drug abuse, is described. Asymmetric transfer hydrogenation of imines with use of Noyori's catalyst was used as the key step and (-)-(S)-stepholidine was synthesized in 6 steps, with 42% overall yield and >99% ee.
authors: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
authors: Jian-Jun
authors: JJ
authors: Cheng
authors: Yu-She
authors: YS
authors: Yang
mesh_terms: D014150:Antipsychotic Agents; D001599:Berberine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006865:Hydrogenation; D007097:Imines; D013237:Stereoisomerism
chemical_list: D014150:Antipsychotic Agents; D007097:Imines; D001599:Berberine; C010513:stepholidine