A stiff blow from the stroma: collagen crosslinking drives tumor progression.
Matrix stiffness is an important microenvironmental cue that regulates cell growth, motility, and differentiation. In a recent Cell report, Weaver and colleagues implicate lysyl-oxidase-mediated collagen crosslinking as a contributor to tumor matrix stiffening, which leads to enhanced integrin signaling and invasive behavior in tumors.
Ng
Mei Rosa
MR
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Brugge
Joan S
JS
D003094:Collagen / Q000378:metabolism*; D018450:Disease Progression; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000378:metabolism; D006801:Humans; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D010766:Phosphorylation; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism
D003094:Collagen; D008249:Protein-Lysine 6-Oxidase; D051416:Focal Adhesion Protein-Tyrosine Kinases