Photophysical properties of clozapine and determination of its concentration by using Eu(III)-dipicolinic acid complex as photo probe.
Clozapine drug is photo-stable under irradiation of light for a long time, so we can store it in difficult and hot conditions. In addition the activity of clozapine is inhibited of the absorption spectra in the presence of glucose and enhanced in the presence of iron(III). We succeeded in detecting the concentration of clozapine in the range 1-60x10(-9)M using Eu(III)-dipicolinic acid complex as photo probe type and using Stern-Völmer equation to determine the Stern-Völmer constant, critical radius and the mechanism of quenching of luminescence of Eu(III)-dipicolinic acid complex is found to be of dipolar-dipolar interaction.
Bakir
Esam
E
Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt. Esambakir99@yahoo.com
D014150:Antipsychotic Agents / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry*; D003024:Clozapine / Q000737:chemistry*; D005063:Europium / Q000737:chemistry*; D015394:Molecular Structure; D010777:Photochemistry / Q000379:methods*; D010848:Picolinic Acids / Q000737:chemistry*
D014150:Antipsychotic Agents; D002614:Chelating Agents; D010848:Picolinic Acids; D005063:Europium; D003024:Clozapine; C004860:dipicolinic acid