Antimicrobial susceptibility of multidrug-resistant Streptococcus pneumoniae strains with penicillin MICs of 8 to 32 mg/L.
The in vitro activity of 22 antibiotics (including novobiocin) and beta-lactam/gentamicin combinations was assessed against 11 multidrug-resistant pneumococcal strains. Among orally administered drugs, only telithromycin, levofloxacin, and linezolid were active against all isolates, but their use is not indicated in pediatrics. Novobiocin could be a potential therapeutic alternative.
Rodríguez-Cerrato
Violeta
V
Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundación Jiménez Díaz-Capio, 28040 Madrid, Spain. vrodriguez@cib.csic.es
Gracia
Matilde
M
Del Prado
Gema
G
Huelves
Lorena
L
Naves
Plínio
P
Ruiz
Vicente
V
Ponte
Carmen
C
Soriano
Francisco
F
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D011008:Pneumococcal Infections / Q000382:microbiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D010406:Penicillins