title: Highly enantioselective 3-furylation of ketones using (3-furyl)titanium nucleophile.
abstract: A novel asymmetric 3-furyl addition of (3-furyl)Ti(O(i)Pr)(3) to ketones in the presence of 10 mol % (S)-BINOL is reported. The catalytic system works excellently for aromatic ketones, alpha- or beta-halophenones, alpha,beta-unsaturated ketones, and acetylfuran, affording products in high yields with excellent enantioselectivities of up to 97% ee.
authors: Department of Chemistry, National Chung Hsing University, Taichung 402, Taiwan.
authors: Shuangliu
authors: S
authors: Zhou
authors: Chi-Ren
authors: CR
authors: Chen
authors: Han-Mou
authors: HM
authors: Gau