title: Multivalent catanionic GalCer analogs derived from first generation dendrimeric phosphonic acids.
abstract: The synthesis and characterization of a new series of catanionic multivalent analogs of GalCer is described. These systems are based on phosphonic acid terminated dendrimers and N-hexadecylamino lactitol moieties. Despite important structural differences that affect the dendrimers' outer-shell, these supramolecular assemblies showed a fairly comparable anti-HIV-1 activity. All compounds have submicromolar IC(50) in a cell-based HIV-infection model but also a high general cytotoxicity.
authors: Laboratoire de Chimie de Coordination du CNRS, UPR 8241, 205 Route de Narbonne, F-31077 Toulouse, France.
authors: Alexandra
authors: A
authors: Pérez-Anes
authors: Cristina
authors: C
authors: Stefaniu
authors: Christine
authors: C
authors: Moog
authors: Jean-Pierre
authors: JP
authors: Majoral
authors: Muriel
authors: M
authors: Blanzat
authors: Cédric-Olivier
authors: CO
authors: Turrin
authors: Anne-Marie
authors: AM
authors: Caminade
authors: Isabelle
authors: I
authors: Rico-Lattes
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005699:Galactosylceramides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D063065:Organophosphonates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D050091:Dendrimers; D005699:Galactosylceramides; D063065:Organophosphonates