title: An automatic quantification and registration strategy to create a gene expression atlas of zebrafish embryogenesis.
abstract: In order to properly understand and model the gene regulatory networks in animals development, it is crucial to obtain detailed measurements, both in time and space, about their gene expression domains. In this paper, we propose a complete computational framework to fulfill this task and create a 3D Atlas of the early zebrafish embryogenesis annotated with both the cellular localizations and the level of expression of different genes at different developmental stages. The strategy to construct such an Atlas is described here with the expression pattern of 5 different genes at 6 hours of development post fertilization.
authors: Biomedical Image Technologies, ETSIT, Universidad Politécnica de Madrid, Madrid 28040 Spain. ccastro@die.upm.es
authors: C
authors: C
authors: Castro
authors: M A
authors: MA
authors: Luengo-Oroz
authors: S
authors: S
authors: Desnoulez
authors: L
authors: L
authors: Duloquin
authors: L
authors: L
authors: Fernandez-de-Manuel
authors: S
authors: S
authors: Montagna
authors: M J
authors: MJ
authors: Ledesma-Carbayo
authors: P
authors: P
authors: Bourgine
authors: N
authors: N
authors: Peyrieras
authors: A
authors: A
authors: Santos
mesh_terms: D000818:Animals; D001331:Automation; D018507:Gene Expression Regulation, Developmental; D015027:Zebrafish / Q000196:embryology*