title: Synthesis and bioimmunological efficiency of poly(2-oxazolines) containing a free amino group.
abstract: Novel amphiphilic copolymers on the basis of 2-oxazolines containing a free amino group were prepared. The copolymers were synthesized by the living cationic polymerization of 2-ethyl-2-oxazoline (ETOX) and 2-(4-aminophenyl)-2-oxazoline (APOX). The main goal of this work was the synthesis of water soluble polymer material with the defined number of functional groups necessary for the attachment of proteins and polysaccharides. A high concentration of free amino groups allows immobilization of various biosubstances, e.g. drugs, proteins or polysaccharides. Thermal properties have been studied with respect to the composition of the copolymers. Cytotoxicity and the bioimmunological efficiency of the selected copolymer were studied.
authors: Polymer Institute, Centre of Excellence GLYCOMED, Slovak Academy of Sciences, Dubravska cesta 9, 84236, Bratislava, Slovakia. juraj.kronek@savba.sk
authors: J
authors: J
authors: Kronek
authors: J
authors: J
authors: Luston
authors: Z
authors: Z
authors: Kroneková
authors: E
authors: E
authors: Paulovicová
authors: P
authors: P
authors: Farkas
authors: N
authors: N
authors: Petrencíková
authors: L
authors: L
authors: Paulovicová
authors: I
authors: I
authors: Janigová
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002470:Cell Survival; D008264:Macrophages / Q000378:metabolism; D008422:Materials Testing; D051379:Mice; D010080:Oxazoles / Q000737:chemistry*; D010587:Phagocytosis; D011108:Polymers / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D016897:Respiratory Burst; D013696:Temperature; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology; D013997:Time Factors
chemical_list: C552863:2-(4-aminophenyl)-2-oxazoline; D001672:Biocompatible Materials; D010080:Oxazoles; D011108:Polymers; D011134:Polysaccharides; D011506:Proteins; D013778:Tetrazolium Salts; D013844:Thiazoles; C552862:2-ethyl-2-oxazoline; C022616:thiazolyl blue