title: [The expression and significance of nerve growth factor and its receptors in pancreatic ductal adenocarcinoma].
abstract: OBJECTIVE
  To investigate nerve growth factor (beta-NGF) and its receptors expression in human pancreatic ductal adenocarcinoma.
  
  
  METHODS
  Expression and distribution of beta-NGF, tyrosine kinase A (TrKA) and P75(NGFR) were detected in operation tissue specimens of pancreatic ductal adenocarcinoma with immunohistochemistry and real-time PCR. Relations of beta-NGF and its receptors with clinical pathological characters, especially nerve invasion were analyzed.
  
  
  RESULTS
  beta-NGF and TrKA expression are higher in pancreatic adenocarcinoma than normal pancreas, and the differences are significant (P < 0.01). beta-NGF and TrKA expression are associated with the differentiation grades (DG), lymphatic node metastasis, nerve invasion and surgical pathological stages. Poorer of DG and later stages, more expression of beta-NGF and TrKA. beta-NGF and TrKA expression have positive correlations. beta-NGF, TrKA and P75(NGFR) mRNA expression have significantly increased 3.84, 4.23 and 2.41 times than normal tissues by real-time PCR, respectively.
  
  
  CONCLUSIONS
  beta-NGF and TrKA might play potential roles in carcinogenesis for pancreatic cancer, have affinity with clinicopathological characters of pancreatic cancer. beta-NGF and TrKA may have mutual effect in signal transduction leading to perineural invasion of pancreatic carcinoma.
authors: Oncological Department, Rizhao People's Hospital, Rizhao Cancer Therapy Center, Rizhao 276826, China. menglx001623@163.com
authors: Ling-Xin
authors: LX
authors: Meng
authors: Zhao-Jun
authors: ZJ
authors: Ding
authors: Xi-Ping
authors: XP
authors: Chen
authors: Li-Sheng
authors: LS
authors: Fei
authors: Yu-Hua
authors: YH
authors: Chi
authors: Zhi-Gang
authors: ZG
authors: Zhao
authors: Xiao-Fang
authors: XF
authors: Wang
authors: Xi-Shan
authors: XS
authors: Hao
mesh_terms: D000328:Adult; D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020932:Nerve Growth Factor / Q000378:metabolism*; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism*; D020917:Receptor, trkA / Q000378:metabolism*
chemical_list: D020800:Receptor, Nerve Growth Factor; D020932:Nerve Growth Factor; D020917:Receptor, trkA