Bioactive diterpenes from the aerial parts of Anisochilus harmandii.
Two new diterpenes, 4- EPI-triptobenzene L ( 1) and 12- O-deacetyl-6- O-acetyl-19- acetyloxycoleon Q ( 2), as well as eight known diterpenes ( 3- 10) were isolated from the aerial parts of Anisochilus hamandii. Structures of the isolated compounds were identified from spectroscopic evidence. Compounds 1, 2, 5, and 10 exhibited antiplasmodial activity against Plasmodium falciparum (IC (50) 4.70, 2.90, 3.03, and 7.20 microg/mL, respectively), while 3, 5, and 7 showed antimycobacterial activity against Mycobacterium tuberculosis (MIC 50 microg/mL). In addition, only 10 showed strong cytotoxicity against NCI-H187 cells (IC (50) 4.43 microg/mL).
Lekphrom
Ratsami
R
Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Kanokmedhakul
Somdej
S
Kanokmedhakul
Kwanjai
K
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D000962:Antimalarials / Q000302:isolation & purification*; D004224:Diterpenes / Q000302:isolation & purification*; D004353:Drug Evaluation, Preclinical; D019686:Lamiaceae / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000962:Antimalarials; D004224:Diterpenes