title: Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs.
abstract: BACKGROUND
  Genome-wide linkage studies for Alzheimer's disease have implicated several chromosomal regions as potential loci for susceptibility genes.
  
  
  METHODS
  In the present study, we have combined a selection of affected relative pairs (ARPs) from the UK and the USA included in a previous linkage study by Myers et al. (Am J Med Genet, 2002), with ARPs from Sweden and Washington University. In this total sample collection of 397 ARPs, we have analyzed linkage to chromosomes 1, 9, 10, 12, 19 and 21, implicated in the previous scan.
  
  
  RESULTS
  The analysis revealed that linkage to chromosome 19q13 close to the APOE locus increased considerably as compared to the earlier scan. However, linkage to chromosome 10q21, which provided the strongest linkage in the previous scan could not be detected.
  
  
  CONCLUSIONS
  The present investigation provides yet further evidence that 19q13 is the only chromosomal region consistently linked to Alzheimer's disease.
authors: Section of Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. elin.blom@pubcare.uu.se
authors: Elin S
authors: ES
authors: Blom
authors: Vilmantas
authors: V
authors: Giedraitis
authors: Sampath
authors: S
authors: Arepalli
authors: Marian L
authors: ML
authors: Hamshere
authors: Omanma
authors: O
authors: Adighibe
authors: Alison
authors: A
authors: Goate
authors: Julie
authors: J
authors: Williams
authors: Lars
authors: L
authors: Lannfelt
authors: John
authors: J
authors: Hardy
authors: Fabienne Wavrant-De
authors: FW
authors: Vrièze
authors: Anna
authors: A
authors: Glaser
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D018895:Microsatellite Repeats; D008875:Middle Aged; D006113:United Kingdom; D014481:United States
chemical_list: D001057:Apolipoproteins E