title: [Association of male infertility with (CAG)n polymorphism of the androgen receptor gene: a meta-analysis].
abstract: OBJECTIVE
  To assess the association of male infertility with CAG repeat polymorphism of the androgen receptor (AR) gene by meta-analysis.
  
  
  METHODS
  We identified the case-control studies on the relationship of male infertility with CAG repeats of the AR gene by searching Medline/PubMed and CBM databases, and conducted meta-analysis on the data obtained with the RevMan 4.2 software.
  
  
  RESULTS
  Thirty-two eligible articles were selected in this study, including 3,153 idiopathic infertile men and 2,314 controls. The combined data statistics showed that all the infertile men had a significantly higher mean of CAG repeats than the controls (SMD = 0.27, 95% CI: 0.17-0.37, P < 0.01). The specific SMD between the infertile patients and controls was 0.29, 95% CI: 0.08-0.50 for the azoospermic men, 0.27, 95% CI: 0.13-0.41 for the moderate oligozoospermic men, and 0.18, 95% CI: 0.02-0.33 for the severe oligozoospermic cases. The results of sensitivity analyses were consistent with those mentioned above.
  
  
  CONCLUSIONS
  The increased length of CAG repeats in the AR gene may be correlated with the risk of the impairment of spermatogenesis.
authors: Department of Biochemistry and Molecular Biology, Chengdu Medical College, Chengdu, Sichuan 610081, China.
authors: Ya
authors: Y
authors: Li
authors: Lun-an
authors: LA
authors: Wang
authors: Tai-xiang
authors: TX
authors: Wu
mesh_terms: D006801:Humans; D007248:Infertility, Male / Q000209:etiology* / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D011944:Receptors, Androgen / Q000235:genetics*; D018911:Trinucleotide Repeats
chemical_list: D011944:Receptors, Androgen