Optical reflectance spectroscopy for detection of human prostate cancer.
We present the method and application of optical reflectance spectroscopy to differentiate prostate cancer from normal tissue using a needle like, bifurcated, fiber-optic probe. An analytical expression to model light reflectance recently published by Zonios et. al. was used to derive optical properties of tissue. A total of 23 cases of human prostate specimens were investigated to analyze statistical differences between the respective cancerous tissues versus normal tissues. The results demonstrate that the derived hemodynamic parameters and optical properties can serve as good bio-markers to differentiate tumor tissue from normal tissue in human prostate.
Sharma
Vikrant
V
International Techlink Group, Inc, Arlington, TX 76010, USA. evikrant@gmail.com
Kashyap
Dheerendra
D
Mathker
Aditya
A
Narvenkar
Sweta
S
Bensalah
Karim
K
Kabbani
Wareef
W
Tuncel
Altug
A
Cadeddu
Jeffrey A
JA
Liu
Hanli
H
D000465:Algorithms; D014408:Biomarkers, Tumor / Q000032:analysis*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D008297:Male; D009391:Nephelometry and Turbidimetry / Q000379:methods*; D010100:Oxygen / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D013057:Spectrum Analysis / Q000379:methods*
D014408:Biomarkers, Tumor; D010100:Oxygen