Characterizations and anti-tumor activities of three acidic polysaccharides from Angelica sinensis (Oliv.) Diels.
In this study, three acidic polysaccharides (APS-3a, APS-3b and APS-3c) were obtained from Angelica sinensis (Oliv.) Diels. They displayed different structural features and anti-tumor activities. APS-3b and APS-3c significantly inhibited the growth of S180 tumors and increased the life spans of S180 tumor-bearing mice, whereas APS-3a had no significant effect. Further experiments showed that APS-3b and APS-3c could cause a concentration-dependent proliferation of the splenocytes, up-regulate IFN-gamma, IL-2 and IL-6 mRNA expressions in splenocytes and stimulate the productions of NO and TNF-alpha in peritoneal macrophages. Taken together, the three acidic polysaccharides displayed different anti-tumor activities which were associated with their different structural characteristics.
Cao
Wei
W
Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, 169 West Changle Road, Xi'an, Shaanxi 710032, China.
Li
Xiao-Qiang
XQ
Wang
Xiang
X
Li
Tao
T
Chen
Xi
X
Liu
Shui-Bing
SB
Mei
Qi-Bing
QB
D000143:Acids; D029971:Angelica sinensis / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002850:Chromatography, Gel; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D005786:Gene Expression Regulation / Q000187:drug effects; D008136:Longevity / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012510:Sarcoma 180; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology
D000143:Acids; D000970:Antineoplastic Agents; D016207:Cytokines; D011134:Polysaccharides; D012333:RNA, Messenger