Osmolyte solutions and protein folding.
In this brief review we discuss the evolution of recent thought regarding the role and mechanism of osmolytes with respect to protein stability. Osmolytes are naturally occurring intracellular compounds that change the protein folding landscape. Contributions from experiments are considered in the context of current theory and simulation results.
Hu
Char Y
CY
Chemistry Department, University of Houston, Houston, TX 77204-5003, USA.
Pettitt
B Montgomery
BM
Roesgen
Joerg
J