[Clinical implications of undercarboxylated osteocalcin].
Importance of vitamin K has been suggested to maintain and improve bone strength. The serum concentration of undercarboxylated osteocalcin (ucOC) is utilized to assess the vitamin K status in bone metabolism. The clinical threshold for ucOC has been determined to discriminate the people at risk for fragility fractures from the view points of vitamin K metabolism. The measurement of ucOC would be useful to select the patients who require vitamin K(2) regimen and to assess the effectiveness of vitamin K(2) therapy.
Hosoi
Takayuki
T
Department of Clinical Research and Development, National Center for Geriatrics and Gerontology, Japan.
D015415:Biomarkers / Q000097:blood; D001842:Bone and Bones / Q000378:metabolism*; D005598:Fractures, Spontaneous / Q000175:diagnosis / Q000517:prevention & control*; D006801:Humans; D015675:Osteocalcin / Q000097:blood* / Q000502:physiology; D010024:Osteoporosis / Q000175:diagnosis* / Q000188:drug therapy / Q000517:prevention & control*; D012306:Risk; D024482:Vitamin K 2 / Q000008:administration & dosage* / Q000378:metabolism
D015415:Biomarkers; D015675:Osteocalcin; D024482:Vitamin K 2