title: Diastereoselective synthesis of syn-1,3-diols by titanium-mediated reductive coupling of propargylic alcohols.
abstract: A titanium-mediated, hydroxy-directed reductive coupling reaction of propargylic alcohols and aldehydes/ketones is described. Excellent diastereoselectivity and synthetically useful yields have been obtained for a range of substrates. This transformation has enabled a highly convergent three-component approach to syn-1,3-diols using (trimethylsilyl)acetylene as a C1 linchpin.
authors: Depeartment of Chemistry, Texas A&M University, College Station, Texas 77842-3092, USA.
authors: Guo-Qiang
authors: GQ
authors: Tian
authors: Thomas
authors: T
authors: Kaiser
authors: Jiong
authors: J
authors: Yang
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry*; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
chemical_list: D000438:Alcohols; D009942:Organometallic Compounds; D014025:Titanium