Target genes suitable for silencing approaches and protein product interference in ovarian epithelial cancer.
Gene expression profiling studies and conventional approaches for the identification of genes involved in the initiation and progression of ovarian cancer have identified a plethora of potential therapeutic targets. This review summarizes the targets that show promise for specific interference in cancer cells, groups them according to their subcellular localization and involved biological processes and discusses their impact on experimental, pre-clinical and clinical therapy.
Malek
Anastasia
A
Institute of Pathology, Charité Universitätsmedizin Berlin, Germany.
Schäfer
Reinhold
R
Tchernitsa
Oleg
O
D017209:Apoptosis / Q000235:genetics; D048708:Cell Growth Processes / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D020868:Gene Silencing; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology