Going viral: fusiform vertebrobasilar and internal carotid aneurysms with varicella angiitis and common variable immunodeficiency.
Intracranial aneurysms in the pediatric population are relatively rare entities. Immunocompromised patients (often from HIV/AIDS or pharmacological immunosuppression) represent a significant fraction of children with cerebral aneurysms. One proposed mechanism of aneurysm formation in these patients is from direct infection of the affected arteries. In this study, the authors report on a case of a 14-year-old girl with common variable immunodeficiency with T-cell dysfunction and a CSF polymerase chain reaction test positive for varicella-zoster virus who underwent evaluation for carotid and basilar artery fusiform aneurysms.
Daugherty
Wilson P
WP
Department of Neurosurgery, Mayo Clinic, 200 1st Street Southwest, Rochester, Minnesota 55905, USA. daugherty.wilson@mayo.edu
Clarke
Michelle J
MJ
Cloft
Harry J
HJ
Lanzino
Giuseppe L
GL
D000212:Acyclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D000293:Adolescent; D000783:Aneurysm / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D015901:Angiography, Digital Subtraction; D000998:Antiviral Agents / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D001488:Basilar Artery; D002340:Carotid Artery Diseases / Q000150:complications; D002343:Carotid Artery, Internal; D002533:Cerebral Angiography; D017074:Common Variable Immunodeficiency / Q000150:complications*; D005260:Female; D006562:Herpes Zoster / Q000188:drug therapy; D006801:Humans; D007091:Image Processing, Computer-Assisted; D002532:Intracranial Aneurysm / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D018810:Magnetic Resonance Angiography; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology; D014057:Tomography, X-Ray Computed; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives / Q000627:therapeutic use; D014657:Vasculitis / Q000150:complications* / Q000821:virology*; D014711:Vertebral Artery
D000998:Antiviral Agents; D010975:Platelet Aggregation Inhibitors; D014633:Valine; D000077483:Valacyclovir; D001241:Aspirin; D000212:Acyclovir