Synthesis and spectroscopic and DNA-binding properties of fluorogenic acridine-containing cyanine dyes.
The synthesis of a new subclass of mono- and polymethine cyanine dyes that incorporate an acridinium moiety and that absorb in the orange to near-infrared region of the spectrum is reported. The mono-, tri-, and pentamethine dyes in particular exhibit promising fluorogenic properties. Their ability to aggregate in solution and to interact with B-DNA is also discussed.
Mahmood
Tariq
T
ISIS Université de Strasbourg 8, BP 70028, 67083 Strasbourg, France.
Paul
Alexis
A
Ladame
Sylvain
S
D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry*; D001483:Base Sequence; D001665:Binding Sites; D002232:Carbocyanines / Q000138:chemical synthesis* / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D008958:Models, Molecular; D011485:Protein Binding; D013050:Spectrometry, Fluorescence; D013057:Spectrum Analysis
D000166:Acridines; D002232:Carbocyanines; D005456:Fluorescent Dyes; D004247:DNA