An unnatural PIP simulates growth factor signaling.
In this issue of Chemistry & Biology, Laketa et al. describe the synthesis of a membrane permeant phosphoinositide lipid that acts to stimulate PI(3,4,5)P(3)-dependent signaling without the need of growth factor stimulation.
Swan
Laura
L
Department of Cell Biology, Yale School of Medicine, New Haven, CT 06510, USA. laura.swan@yale.edu
D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D018129:Phosphatidylinositol Phosphates / Q000138:chemical synthesis / Q000737:chemistry; D010716:Phosphatidylinositols / Q000138:chemical synthesis / Q000737:chemistry*; D015398:Signal Transduction; D013329:Structure-Activity Relationship
D036341:Intercellular Signaling Peptides and Proteins; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; C060974:phosphatidylinositol 3,4,5-triphosphate; C060980:phosphatidylinositol 3,4-diphosphate; D019869:Phosphatidylinositol 3-Kinases