Synthesis of pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones.
A solid-phase synthesis of 5-aminopyrazole has been developed and applied to the preparation of pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones. In this strategy, a one-pot reaction from 5-aminopyrazoles to the pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones which provided the compounds in good yields was demonstrated. Using this synthetic strategy, we prepared a representative set of 16 pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones.
Gao
Yaojun
Y
Department of Chemistry, National University of Singapore, Singapore.
Lam
Yulin
Y
D020650:Combinatorial Chemistry Techniques / Q000379:methods; D015394:Molecular Structure; D047069:Pyrazolones / Q000138:chemical synthesis* / Q000737:chemistry; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry
D047069:Pyrazolones; D013777:Tetrazoles