title: Relationship between costs of lifestyle interventions and weight loss in overweight adults.
abstract: Lifestyle interventions in a healthcare setting are effective for weight loss, but it is unclear whether more expensive interventions result in more weight loss. Our objective was to explore the relationship between intervention costs and effectiveness in a systematic review of randomized trials. Intervention studies were selected from 14 reviews and from a systematic MEDLINE-search. Studies had to contain a dietary and a physical activity component and report data on measured weight loss in healthy Caucasian overweight adults. Intervention costs were calculated in a standardized way. The association between costs and percentage weight loss after 1 year was assessed using regression analysis. Nineteen original studies describing 31 interventions were selected. The relationship between weight loss and intervention costs was best described by an asymptotic regression model, which explained 47% of the variance in weight loss. A clinically relevant weight loss of 5% was already observed in interventions of approximately euro110. Results were similar in an intention-to-treat analysis. In conclusion, lifestyle interventions in health care for overweight adults are relatively cheap and higher intervention costs are associated with more weight loss, although the effect of costs on weight loss levels off with growing costs.
authors: Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, 3720 BA Bilthoven, the Netherlands. rik.bogers@rivm.nl
authors: R P
authors: RP
authors: Bogers
authors: J C M
authors: JC
authors: Barte
authors: C M A
authors: CM
authors: Schipper
authors: S M C
authors: SM
authors: Vijgen
authors: E L
authors: EL
authors: de Hollander
authors: L
authors: L
authors: Tariq
authors: I E J
authors: IE
authors: Milder
authors: W J E
authors: WJ
authors: Bemelmans
mesh_terms: D001521:Behavior Therapy; D003362:Cost-Benefit Analysis; D004035:Diet Therapy / Q000191:economics; D015444:Exercise / Q000502:physiology; D006801:Humans; D008019:Life Style; D050177:Overweight / Q000191:economics* / Q000628:therapy*; D016896:Treatment Outcome; D015431:Weight Loss