title: Hemorrhagic gastritis and duodenitis following celiac plexus neurolysis.
abstract: BACKGROUND
  Neurolytic celiac plexus block is a well established intervention to palliate pain, and it potentially improves quality of life in patients suffering from an upper abdominal malignancy, specifically pancreatic cancer.
  
  
  METHODS
  We describe a 61-year-old female with a history of pancreatic cancer, unexplained transfusion dependent anemia with a normal recent upper endoscopy, and abdominal pain, who had previously undergone gastrojejunostomy and a Roux-en-Y hepaticojejunostomy as well as chemotherapy and radiation therapy. She suffered from intractable abdominal pain and elected to undergo palliative celiac plexus neurolysis.
  
  
  RESULTS
  The patient initially appeared to tolerate celiac plexus block well, however, 45 minutes after the procedure, the patient had bright red blood per rectum followed by bloody diarrhea. Her abdomen was soft and non-tender with minimal distention and positive bowel sounds. The patient's hemoglobin decreased to 7.5 g/dl from 9.0 g/dl, and she received a blood transfusion. Upper endoscopy and enteroscopy demonstrated diffuse hemorrhagic gastritis and duodenitis. The bleeding was controlled and the patient remained hemodynamically stable. Ultimately, the patient did well and was discharged home.
  
  
  CONCLUSIONS
  We report a case of a patient with known history of gastritis and duodenitis, who developed severe upper GI bleeding immediately following the celiac plexus neurolysis. There are no published reports documenting similar cases. It is difficult to offer a precise physiologic explanation for this complication. However, we speculate that inhibition of sympathetic tone from the celiac plexus neurolysis caused increased blood flow to the GI system, and this resulted in active bleeding from previously indolent hemorrhagic gastritis and duodenitis.
  
  
  CONCLUSIONS
  It may be beneficial for patients with a history of gastritis, duodenitis or GI bleeding to undergo a careful upper GI evaluation prior to celiac plexus neurolysis.
authors: Department of Neurology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA. scott.pello@jeffersonhospital.org
authors: Scott
authors: S
authors: Pello
authors: Alan
authors: A
authors: Miller
authors: Tony
authors: T
authors: Ku
authors: Dajie
authors: D
authors: Wang
mesh_terms: D015746:Abdominal Pain / Q000209:etiology / Q000628:therapy; D001340:Autonomic Nerve Block / Q000009:adverse effects*; D002447:Celiac Plexus / Q000503:physiopathology; D004382:Duodenitis / Q000209:etiology*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications