A comparative analysis of two different sets of Y-chromosome short tandem repeats (Y-STRs) on a common population panel.
A comparative analysis of two Y-STR loci sets was conducted on a population sample of 224 individuals, 114 Caucasians and 110 African Americans. One set of loci, designated the OSU 10-locus set, comprises variable, single copy, male-specific loci that are dispersed across the Y-chromosome. Parallel evaluations were performed using the 10 Y-chromosome loci most frequently used for forensic analysis, the loci chosen as the SWGDAM Y-STR loci. The OSU 10-locus set had a greater average number of alleles per locus and higher average gene diversity than the SWGDAM loci. The OSU 10-locus set found 220 unique haplotypes in 224 individuals. In approximately 6000 pairwise haplotype comparisons for each population with each set of loci, the OSU 10-locus set also yielded a greater average number of allelic differences per pair than the SWGDAM loci. Finally, the overall linkage disequilibrium levels were lower for the OSU 10-locus set in the Caucasian population. In general, the OSU 10-locus set revealed a higher power of discrimination than the SWGDAM set.
Maybruck
Julie L
JL
Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA. maybruck.2@osu.edu
Hanson
Erin
E
Ballantyne
Jack
J
Budowle
Bruce
B
Fuerst
Paul A
PA
D044383:Black People / Q000235:genetics; D041322:Chromosomes, Human, Y; D004247:DNA / Q000235:genetics; D016172:DNA Fingerprinting; D017931:DNA Primers; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D016133:Polymerase Chain Reaction; D020080:Tandem Repeat Sequences; D044465:White People / Q000235:genetics; D001741:Black or African American
D017931:DNA Primers; D004247:DNA