[Expression of angiotensin II receptor subtypes in atrial fibrillation underlying rheumatic heart disease].
OBJECTIVE
To examine the expression of angiotensin II (Ang II) receptor subtypes in human left and right atrial tissue in atrial fibrillation underlying rheumatic heart disease.


METHODS
Atrial tissue samples were obtained from 39 patients with rheumatic heart disease, 25 with atrial fibrillation (AF) and 14 with sinus rhythm(SR) during open heart surgery. AT1 and AT2 mRNA levels were measured with semi-quantitative reverse transcription polymerase chain reaction techniques. AT1 and AT2 protein levels were measured with immunohistochemical techniques.


RESULTS
Compared with that of the SR group, left atrial inner diameter was significantly increased in the patients of the AF group. The AT1 mRNA and protein levels in the LA significantly increased in patients with AF compared with those in patients with SR (P < 0.05), whereas AT2 mRNA and protein were not significantly altered. Investigations of Ang II receptor subtypes' mRNA and protein levels in the RA did not exhibit any significant changes either in AT1 or AT2 in patients with AF and SR.


CONCLUSIONS
AF is associated with an up-regulation of AT1 in LA, but does not appear to influence the AT2 expression. This may indicate a possible pathophysiologic role for renin-angiotensin system in the development of AF. The series of effects mediated by AT1 activation may be one of the molecular mechanisms involved in the process of atrial remodeling.
Jiang
Hua
H
Department of Cardiology, Tianjin Chest Hospital, Tianjin Cardiology Research Institute, Tianjin 300051, China.
Ma
Li-Jun
LJ
Cong
Hong-Liang
HL
Jiang
Nan
N
Mao
Yong-Min
YM
Xu
Mei-Lin
ML
Cui
Rang-Zhuang
RZ
D000328:Adult; D001281:Atrial Fibrillation / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011945:Receptors, Angiotensin / Q000378:metabolism*; D012084:Renin-Angiotensin System; D012214:Rheumatic Heart Disease / Q000150:complications / Q000378:metabolism*
D011945:Receptors, Angiotensin