title: Multi-scale modeling of excitation-contraction coupling in the normal and failing heart.
abstract: Here we describe new computational models of cardiac electromechanics starting from the cellular scale and building to the tissue, organ and system scales. We summarize application to human genetic diseases (LQT1 and LQT3) and to modeling of congestive heart failure.
authors: Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA. roy@bioeng.ucsd.edu
authors: Roy C P
authors: RC
authors: Kerckhoffs
authors: Stuart G
authors: SG
authors: Campbell
authors: Sarah N
authors: SN
authors: Flaim
authors: Elliot J
authors: EJ
authors: Howard
authors: Jazmin
authors: J
authors: Sierra-Aguado
authors: L J
authors: LJ
authors: Mulligan
authors: Andrew D
authors: AD
authors: McCulloch
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004594:Electrophysiology / Q000379:methods; D004867:Equipment Design; D006321:Heart / Q000503:physiopathology*; D006329:Heart Conduction System; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D008133:Long QT Syndrome; D008955:Models, Cardiovascular; D008957:Models, Genetic; D032342:Muscle Cells / Q000473:pathology; D009154:Mutation; D009200:Myocardial Contraction; D012984:Software