Tetraazaindenes derived from dihydropyrazines with DNA strand-breaking activity.
Dihydropyrazines (DHPs), which exhibit DNA strand-breaking activity and other biological activities associated with the generation of radical species, reacted with thiourea to give tetraazaindene (TAI) derivatives, despite thiourea is a well known radical scavenger. The structural determination of the TAIs was carried out and formation mechanism of TAI was investigated.
Nakahara
Kazuhide
K
Sojo University, Kumamoto, Japan.
Takechi
Shinji
S
Yamaguchi
Koki
K
Harano
Kazunobu
K
Yamaguchi
Tadatoshi
T
D004249:DNA Damage / Q000187:drug effects*; D004925:Escherichia / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D011719:Pyrazines / Q000737:chemistry* / Q000494:pharmacology; D013778:Tetrazolium Salts / Q000737:chemistry* / Q000494:pharmacology
D011719:Pyrazines; D013778:Tetrazolium Salts