title: Glucose-6-phosphate dehydrogenase deficiency and severe neonatal hyperbilirubinemia: a complexity of interactions between genes and environment.
abstract: Glucose-6-phosphate dehydrogenase deficiency is a commonly occurring genetic condition, likely to be encountered today in virtually any corner of the globe. Sudden episodes of hemolysis associated with the condition may result in exponential increases in serum total bilirubin concentrations to levels at which bilirubin-induced neurologic damage may occur. The hyperbilirubinemia is the result of complex interactions between genes and environment. Neonatal screening programs coupled with parental and medical caretaker education may be successful in limiting the severity of disease.
authors: Department of Neonatology, Shaare Zedek Medical Center, Faculty of Medicine of the Hebrew University, Jerusalem, Israel. kaplan@cc.huji.ac.il
authors: Michael
authors: M
authors: Kaplan
authors: Cathy
authors: C
authors: Hammerman
mesh_terms: D001663:Bilirubin / Q000097:blood*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006461:Hemolysis / Q000502:physiology; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000097:blood / Q000201:enzymology* / Q000473:pathology; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening
chemical_list: D005954:Glucosephosphate Dehydrogenase; D001663:Bilirubin