title: Expedient construction of the Ziegler intermediate useful for the synthesis of forskolin via consecutive rearrangements.
abstract: The Ziegler intermediate, useful for the total synthesis of forskolin, was synthesized in 10 reaction steps starting from commercially available alpha-ionone. This highly efficient synthesis relies on the success of two consecutive highly regio- and stereoselective rearrangements. The current synthesis has not only established an efficient synthetic route to access the Ziegler intermediate but it has also paved a way to the structural optimization of forskolin.
authors: Laboratory of Molecular Engineering and Laboratory of Natural Product Synthesis, Guangzhou Institute of Biomedicine and Health, The Chinese Academy of Sciences, Guangzhou 510663, China.
authors: Heping
authors: H
authors: Ye
authors: Gang
authors: G
authors: Deng
authors: Jun
authors: J
authors: Liu
authors: Fayang G
authors: FG
authors: Qiu
mesh_terms: D031330:Coleus / Q000737:chemistry; D005576:Colforsin / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D045792:Norisoprenoids / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D045792:Norisoprenoids; D005576:Colforsin; C011879:alpha-ionone