Characterization of adipose-derived stem cells: an update.
Adipose tissue is an attractive source of multipotent adult stem cells due to its wide-spread availability, accessibility, and ease of harvest. Adipose-derived stem cells (ASCs), the adherent stromal cell population present within adipose tissue, are easily expanded in culture, able to differentiate along multiple cell-lineage pathways, and have been shown to provide therapeutic benefit in models of injury and disease through immunomodulation, structural integation, and/or trophic support. Recent developments in the characterization of ASCs, specifically their isolation, gene and protein expression, differentiation, and expansion, are reviewed in this article.
Bailey
Alexander M
AM
Department of Plastic Surgery, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Kapur
Sahil
S
Katz
Adam J
AJ
D000273:Adipose Tissue / Q000473:pathology*; D000818:Animals; D002454:Cell Differentiation; D015687:Cell Hypoxia; D018925:Chemokines / Q000378:metabolism; D017228:Hepatocyte Growth Factor / Q000235:genetics / Q000378:metabolism; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism* / Q000473:pathology; D009924:Organ Culture Techniques; D055153:Stem Cell Niche / Q000473:pathology*; D054457:Tissue Scaffolds; D019076:Transgenes / Q000235:genetics
D018925:Chemokines; C066855:HGF protein, human; D017228:Hepatocyte Growth Factor