Impact of ethanol on the developing GABAergic system.
Alcohol intake during pregnancy has a tremendous impact on the developing brain. Embryonic and early postnatal alcohol exposures have been investigated experimentally to elucidate the fetal alcohol spectrum disorders' (FASD) milieu, and new data have emerged to support a devastating effect on the GABAergic system in the adult and developing nervous system. GABA is a predominantly inhibitory neurotransmitter that during development excites neurons and orchestrates several developmental processes such as proliferation, migration, differentiation, and synaptogenesis. This review summarizes and brings new data on neurodevelopmental aspects of the GABAergic system with FASD in experimental telencephalic models.
Isayama
Ricardo Noboro
RN
Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Leite
Paulo Emilio Correa
PE
Lima
Jean Pierre Mendes
JP
Uziel
Daniela
D
Yamasaki
Edna Nanami
EN
D020268:Alcohol-Induced Disorders, Nervous System / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000633:toxicity; D004195:Disease Models, Animal; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D051379:Mice; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009434:Neural Pathways / Q000187:drug effects / Q000196:embryology / Q000254:growth & development; D055495:Neurogenesis / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D013687:Telencephalon / Q000187:drug effects* / Q000196:embryology* / Q000254:growth & development; D005680:gamma-Aminobutyric Acid / Q000187:drug effects* / Q000378:metabolism
D002492:Central Nervous System Depressants; D000431:Ethanol; D005680:gamma-Aminobutyric Acid