title: MELD score, child-pugh score, and decreased albumin as risk factors for gastric variceal bleeding.
abstract: OBJECTIVE
  Ruptured esophagogastric varices are commonly associated with bleeding in patients with portal hypertension. However, the prediction of esophageal variceal bleeding is not matched by means of predicting gastric variceal bleeding. The present study aim is to elucidate risk factors for gastric variceal bleeding.
  
  
  METHODS
  Twelve patients with gastric variceal bleeding and 18 patients receiving preventive treatment for gastric varices were included in the study.
  
  
  RESULTS
  The Child-Pugh (8.0 +/- 0.9 vs. 5.5 +/- 0.3; p = 0.0025) and Model for end-stage liver disease (MELD) (10.6 +/- 2.7 vs. 4.0 +/- 0.9; p = 0.0095) scores were significantly higher for patients with bleeding than for those receiving preventive treatment. Serum albumin concentration was significantly lower in bleeding than in preventive treatment cases, as determined by univariate (2.9 +/- 0.2 vs. 3.7 +/- 0.1 mg/dL; p < 0.0001) and multivariate analyses of serological data (odds ratio, 0.02, 95% confidence interval, 0.001-0.479; p = 0.0144).
  
  
  CONCLUSIONS
  The Child-Pugh and MELD scores were significantly higher for patients with gastric variceal bleeding than for those receiving preventive treatment, and multivariate analysis revealed that serum albumin was significantly lower in patients with gastric variceal bleeding. Control of serum albumin is important in preventing gastric variceal bleeding.
authors: Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kyoto, Japan. sogatti@koto.kpu-m.ac.jp
authors: Koichi
authors: K
authors: Soga
authors: Koichi
authors: K
authors: Tomikashi
authors: Ki-ichirou
authors: K
authors: Miyawaki
authors: Kohei
authors: K
authors: Fukumoto
authors: Naoki
authors: N
authors: Wakabayashi
authors: Hideyuki
authors: H
authors: Konishi
authors: Shoji
authors: S
authors: Mitsufuji
authors: Norimasa
authors: N
authors: Yoshida
authors: Satoshi
authors: S
authors: Kokura
authors: Yuji
authors: Y
authors: Naito
authors: Keisho
authors: K
authors: Kataoka
authors: Toshikazu
authors: T
authors: Yoshikawa
mesh_terms: D004932:Esophageal and Gastric Varices / Q000097:blood / Q000150:complications*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000209:etiology; D006503:Hepatic Veins / Q000503:physiopathology; D006801:Humans; D008297:Male; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis*; D012720:Severity of Illness Index; D014690:Venous Pressure
chemical_list: D012709:Serum Albumin