Microfluidic neurotransmiter-based neural interfaces for retinal prosthesis.
Natural inter-neuronal communication is mediated primarily via neurotransmitter-gated ion channels. While most of the methods for neural interfacing have been based upon electrical stimulation, neurotransmitter-based approaches for the spatially and temporally controlled delivery of neurotransmitters are relatively new. Methods of neurotransmitter stimulation retinal prosthesis may provide new ways to control neural excitation. Experimental results for retinal ganglion cell stimulation demonstrate the feasibility of a neurotransmitter-based retinal prosthesis.
Iezzi
Raymond
R
Mayo Clinic, Rochester, MN 55902, USA. iezzi.raymond@mayo.edu
Finlayson
Paul
P
Xu
Yong
Y
Katragadda
Rakesh
R
D000818:Animals; D004558:Electric Stimulation / Q000379:methods*; D005071:Evoked Potentials / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D012160:Retina; D012165:Retinal Ganglion Cells / Q000502:physiology*; D013997:Time Factors
D018377:Neurotransmitter Agents; D018698:Glutamic Acid