title: Association of TGFBR2 polymorphism with risk of sudden cardiac arrest in patients with coronary artery disease.
abstract: BACKGROUND
  Transforming growth factor ss (TGFss) signaling has been shown to promote myocardial fibrosis and remodeling with coronary artery disease (CAD), and previous studies show a major role for fibrosis in the initiation of malignant ventricular arrhythmias (VA) and sudden cardiac arrest (SCA). Common single nucleotide polymorphisms (SNPs) in TGFss pathway genes may be associated with SCA.
  
  
  OBJECTIVE
  We examined the association of common SNPs among 12 candidate genes in the TGFss pathway with the risk of SCA.
  
  
  METHODS
  SNPs (n = 617) were genotyped in a case-control study comparing 89 patients with CAD and SCA caused by VA to 520 healthy control subjects.
  
  
  RESULTS
  Nineteen SNPs among 5 genes (TGFB2, TGFBR2, SMAD1, SMAD3, SMAD6) were associated with SCA after adjustment for age and sex. After permutation analysis to account for multiple testing, a single SNP in TGFBR2 (rs9838682) was associated with SCA (odds ratio: 1.66, 95% confidence interval: 1.08 to 2.54, P = .02).
  
  
  CONCLUSIONS
  We show an association between a common TGFBR2 polymorphism and risk of SCA caused by VA in the setting of CAD. If validated, these findings support the role of genetic variation in TGFss signaling in SCA susceptibility.
authors: Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143-1354, USA. zhtseng@medicine.ucsf.edu
authors: Zian H
authors: ZH
authors: Tseng
authors: Eric
authors: E
authors: Vittinghoff
authors: Stacy L
authors: SL
authors: Musone
authors: Feng
authors: F
authors: Lin
authors: Dean
authors: D
authors: Whiteman
authors: Ludmila
authors: L
authors: Pawlikowska
authors: Pui-Yan
authors: PY
authors: Kwok
authors: Jeffrey E
authors: JE
authors: Olgin
authors: Bradley E
authors: BE
authors: Aouizerat
mesh_terms: D000368:Aged; D002140:California / Q000453:epidemiology; D016022:Case-Control Studies; D016001:Confidence Intervals; D003324:Coronary Artery Disease / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D015398:Signal Transduction; D017180:Tachycardia, Ventricular / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha; D014481:United States / Q000453:epidemiology; D014693:Ventricular Fibrillation / Q000453:epidemiology / Q000235:genetics
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II