Stem cell therapy for the treatment of acute myocardial infarction.
The last decade has been accompanied by great optimism and interest in the concept of cell or tissue regeneration in the postinfarction myocardium. However, despite the promise, progress was slow. Data derived from multiple controlled studies in hundreds of patients postmyocardial infarction have shown hints of potential benefit but not of the magnitude anticipated. The complexity and hurdles to repair the damaged myocardium have been more daunting than originally estimated. In the end analysis, progress will be made incrementally. The promise for cell therapy continues to be significant, but so are the challenges ahead. This article takes a fresh look at the progress in myocardial regeneration. The authors look at the postmyocardial environment for cues that may guide repair and they look closely at the clinical data for evidence of cardiac regeneration. This evidence is used for suggestions on how to best proceed with future work.
Dinsmore
Jonathan H
JH
Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA.
Dib
Nabil
N
D000818:Animals; D006801:Humans; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy*; D033581:Stem Cell Transplantation; D020257:Ventricular Remodeling