title: Supramolecular interactions between library members modulate the behavior of dynamic combinatorial libraries.
abstract: The presence of a supramolecular network of interactions between library members can lead to very different responses when libraries with identical molecular composition are exposed to the same template. Numerical simulations demonstrate that supramolecular interactions between library members of covalent dynamic combinatorial libraries (DCLs) can affect both degree and selectivity of the response of the library when a template molecule is added.
authors: Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.
authors: A Gastón
authors: AG
authors: Orrillo
authors: Ricardo L E
authors: RL
authors: Furlan
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D046911:Macromolecular Substances / Q000737:chemistry*; D056004:Molecular Dynamics Simulation
chemical_list: D046911:Macromolecular Substances