[A case of rectal GIST treated with imatinib mesylate neoadjuvant therapy to preserve the anus].
A 64-year-old man was admitted to our hospital with anal pain on evacuation. MRI revealed a large rectal submucosal tumor, more than 6 cm in diameter. Fine needle histological diagnosis indicated GIST with moderate risk. The patient was treated with imatinib mesylate in order to preserve the anus. The anal pain and tumor size decreased. Trans-anal local excision was performed. This case suggests that imatinib mesylate can make it possible to treat large rectal GIST cases by preserving anus, if neoadjuvant chemotherapy can be effective.
Sekoguchi
Satoru
S
Department of Gastroenterology, Kyoto First Red Cross Hospital, Japan. satoru-sekoguchi@kyoto1-jrc.org
Okuyama
Yusuke
Y
Enoki
Yasuyuki
Y
Kawakami
Takumi
T
Tomie
Akira
A
Yamada
Nobuhisa
N
Yoriki
Hiroyuki
H
Fukui
Akifumi
A
Hattori
Takeshi
T
Kamata
Kazuhiro
K
Tomatsuri
Naoya
N
Nakamura
Hideki
H
Sato
Hideki
H
Kimura
Hiroyuki
H
Yoshida
Norimasa
N
Shioaki
Yasuhiro
Y
Fujimoto
Sotaro
S
D001003:Anal Canal; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy*; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D012004:Rectal Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate