Structural determination of two new triterpenoids biotransformed from glycyrrhetinic acid by Mucor polymorphosporus.
Five hydroxylated derivatives of glycyrrhetinic acid by Mucor polymorphosporus were isolated. Among them, 6beta, 7beta-dihydroxyglycyrrhentic acid (2) and 27-hydroxyglycyrrhentic acid (3) are new compounds. Their chemical structures were identified by spectral methods including 2D-NMR.
Xin
Xiu Lan
XL
Biotechnology Application Center, Beijing Vocational College of Electronic Science and Technology, Beijing, P. R. China.
Yang
Guowei
G
Gou
Zhan Ping
ZP
Yao
Ji Hong
JH
Lan
Rong
R
Ma
Xiao Chi
XC
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001711:Biotransformation; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009089:Mucor / Q000378:metabolism*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology
C548369:27-hydroxyglycyrrhentic acid; C548368:6,7-dihydroxyglycyrrhentic acid; D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; D006034:Glycyrrhetinic Acid