Toxic effects of T-2 toxin on reproductive system in male mice.
The present study was conducted to evaluate the effects of T-2 toxin on semen quality, fertility and serum testosterone concentration in mice. Adult male mice were mated with sexually mature untreated female mice after being exposed to intraperitoneal injection of T-2 toxin at 0, 5, 10 or 15 mg/kg body weight daily for 7 successive days. Semen quality, serum testosterone concentration and fertility of treated mice were assessed. The results showed that the number of abnormal spermatozoa increased significantly and a significant decrease in spermatozoa with integrated acrosome was observed in males treated with T-2 toxin at all doses, As well, the amount of live spermatozoa decreased significantly in mice treated with 10 and 15 mg/kg body weight T-2 toxin. Low pregnancy rate and high fetal resorption rate were observed when females were mated with T-2 toxin-exposed males. Testicular and cauda epididymal sperm counts, efficiency of sperm production and serum testosterone concentration were significantly reduced in mice treated with T-2 toxin at all doses in a dose-dependent manner. In conclusion, these findings indicated that T-2 toxin presented toxic effects on reproductive system of adult male mice.
Yang
Jian Ying
JY
College of Medical Technology and Engineering, Henan University of Science and Technology, Luo Yang, Henan 471003, China.
Zhang
Yong Fa
YF
Liang
Ai Min
AM
Kong
Xiang Feng
XF
Li
Yuan Xiao
YX
Ma
Kai Wang
KW
Jing
Ai Hua
AH
Feng
Shu Ying
SY
Qiao
Xiao Lan
XL
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D012098:Reproduction / Q000187:drug effects*; D012661:Semen / Q000187:drug effects; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects; D013605:T-2 Toxin / Q000633:toxicity*; D013739:Testosterone / Q000097:blood; D018675:Toxicity Tests
D013739:Testosterone; D013605:T-2 Toxin