In vitro cytotoxicity testing and the application of elastic interconnection technology for short-term implantable electronics.
An electronic device was fabricated consisting of 2 flexible electronic circuit islands, interconnected by a 7 cm long elastic interconnection, which could be elongated for at least 50%. This interconnection was based on gold conductor tracks following a 2-D spring pattern, embedded in a biocompatible silicone elastomer. The complete device was embedded in the same silicone elastomer. An in vitro cytotoxicity extraction test, executed on small test-samples in accordance with the ISO 10 993-1 guidelines, revealed that the applied silicone encapsulation to these samples functioned as a good seal for at least 8 days.
Brosteaux
Dominique
D
CMST, IMEC/Ghent University, Gent-Zwijnaarde, Belgium. dominique.brosteaux@elis.ugent.be
Lippens
Evi
E
Cornelissen
Ria
R
Schacht
Etienne
E
Carta
Riccardo
R
Jourand
Philippe
P
Puers
Robert
R
Axisa
Fabrice
F
Vervust
Thomas
T
Bossuyt
Frederick
F
Vanfleteren
Jan
J
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002645:Chickens; D004582:Electronics, Medical / Q000295:instrumentation* / Q000379:methods*; D019736:Prostheses and Implants / Q000009:adverse effects*; D012828:Silicones / Q000737:chemistry
D012828:Silicones