Identification and characterization of an Ecl1-family gene in Saccharomyces cerevisiae.
We found that YGR146C of Saccharomyces cerevisiae encodes a functional homolog of Ecl1 that is involved in the chronological lifespan of Schizosaccharomyces pombe. When YGR146C is overexpressed, it extends the viability of wild-type S. cerevisiae cells after entry into the stationary phase, as in the case of Ecl1. We propose that Ecl1 family proteins are novel regulatory factors involved in chronological lifespan among yeasts.
Azuma
Kenko
K
Laboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University, Japan.
Ohtsuka
Hokuto
H
Mita
Satoka
S
Murakami
Hiroshi
H
Aiba
Hirofumi
H
D000595:Amino Acid Sequence; D002470:Cell Survival; D005800:Genes, Fungal / Q000235:genetics*; D005822:Genetic Vectors / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics; D010957:Plasmids / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000032:analysis / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
C547504:Ecl1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins