Preview. A shore sign of reprogramming.
Recent genome-wide descriptions of CpG methylation patterns in mammalian cells identified many differentially methylated regions (DMRs) located at CpG island "shores." Feinberg, Daley, and colleagues now report in Nature Genetics that reconfiguration of these DMRs occurs during induced reprogramming (Doi et al., 2009).
Pollard
Steven M
SM
Wellcome Trust Centre for Stem Cell Biology and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QR, UK; UCL Cancer Institute, University College London, London WC1E 6BT, UK.
Stricker
Stefan H
SH
Beck
Stephan
S