title: Interleukin-10: a key cytokine in depression?
abstract: An increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytokine IL-10 is a putative link between two of the most widely reported phenomenon observed in depressed patients: the disruption of the hypothalamic-pituitary-adrenal axis and the imbalanced production of cytokines. If so, IL-10 might represent a novel target for antidepressant therapy.
authors: Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal.
authors: Susana
authors: S
authors: Roque
authors: Margarida
authors: M
authors: Correia-Neves
authors: Ana Raquel
authors: AR
authors: Mesquita
authors: Joana Almeida
authors: JA
authors: Palha
authors: Nuno
authors: N
authors: Sousa