[Comprehensive study of the major morphological forms of gastric cancer in relation to the indices of their prognostic assessment].
The results of a comparative study of a complex of clinical, morphological, prognostic, and immunohistochemical features and parenchymatous-stromal relations in gastric cancer (GC) suggest the rationality of identifying three basic classification histological forms of GC: intestinal, diffuse, and mixed, rather than two forms. The proposed additional identification of the mixed form of GC (MGC) encompasses a significant, early unclassified, tumors of complex structure with the heterodirectional differentiation of the cancerous epithelium, by the type of P. Correa's cascade. When there is tumor growth, this feature completely realizes individual cell kinetic regularities. The decreased tumor parenchymal maturity, which is characteristic of MGC, with complicated and/or distorted parenchymatous-stromal relations at different levels and stages of tumor growth may affect the lower therapy indices. It is obvious that the standard of an inpatient study of GC as a particular cancer nosological entity should take into account the indices of not only the pTNM system, but also the perfected group histological classification of this tumor.
Danilova
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Anichkov
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D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy