Indicators of pretreatment suicidal ideation in adults with major depressive disorder.
OBJECTIVE
In order to evaluate the presence of treatment emergent suicidal ideation (SI), it becomes necessary to identify those patients with SI at the onset of treatment. The purpose of this report is to identify sociodemographic and clinical features that are associated with SI in major depressive disorder (MDD) patients prior to treatment with a selective serotonin reuptake inhibitor.


METHODS
This multisite study enrolled 265 out-patients with non-psychotic MDD. Sociodemographic and clinical features of participants with and without SI were compared post hoc.


RESULTS
Social phobia, bulimia nervosa, number of past depressive episodes, and race were independently associated with SI by one or more SI measure.


CONCLUSIONS
Concurrent social phobia and bulimia nervosa may be potential risk factors for SI in patients with non-psychotic MDD. Additionally, patients with more than one past depressive episode may also be at increased risk of SI.
Morris
D W
DW
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9119, USA. davidw.morris@utsouthwestern.edu
Trivedi
M H
MH
Husain
M M
MM
Fava
M
M
Budhwar
N
N
Wisniewski
S R
SR
Miyahara
S
S
Gollan
J K
JK
Davis
L L
LL
Daly
E J
EJ
Rush
A J
AJ
D000328:Adult; D000368:Aged; D000554:Ambulatory Care Facilities; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D052018:Bulimia Nervosa / Q000150:complications* / Q000175:diagnosis; D057186:Comparative Effectiveness Research; D003710:Demography; D003865:Major Depressive Disorder / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010698:Phobic Disorders / Q000150:complications* / Q000175:diagnosis; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D055502:Secondary Prevention; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D059020:Suicidal Ideation; D013406:Suicide, Attempted / Q000517:prevention & control / Q000523:psychology; D014481:United States; D055815:Young Adult
D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors