[Simple screening method for judging the complex formation between drug and aluminum (III)].
We examined a simple screening method for judging the complex formation between a drug and aluminum(III) on a spot plate. As few drug had color reaction by basing on the binary complex formation of drug-aluminum(III), the ternary complex formation of drug-aluminum(III)-dye was studied this time using 50 kinds of drugs. The dyes used were Chromazurol S and Erythrosin. As a result, in the drug that the complex formation with aluminum(III) was assumed, a remarkable coloration difference was recognized in comparison with the blank prepared under the same conditions. The proposed simple screening method should be very useful for judging instantly the complex formation between a drug and aluminum(III).
Miyachi
Kanako
K
Department of Hospital Pharmacy School of Medicine, Kinki University, Osaka-Sayama, Japan.
Nakao
Masahiro
M
Kurokawa
Hisashi
H
Tomida
Mayu
M
Kamino
Shinichiro
S
Moriyama
Kenzo
K
Yamaguchi
Takako
T
Fujita
Yoshikazu
Y
D000535:Aluminum / Q000032:analysis*; D003124:Colorimetry / Q000379:methods*; D056831:Coordination Complexes / Q000032:analysis*; D004923:Erythrosine; D062385:Hydroxybenzoates; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations / Q000032:analysis*
D056831:Coordination Complexes; D062385:Hydroxybenzoates; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; C015076:chrome azurol S; D000535:Aluminum; D004923:Erythrosine