[Pathogenesis and clinical significance of interleukin-8 and tumor necrosis factor-alpha in cervicitis].
OBJECTIVE
To investigate the relationship between local immune status of vagina and the occurrence of disease in patients with cervicitis.


METHODS
ELISA were used to detect the level of interleukin (IL)-8 and tumor necrosis factor (TNF)alpha in vaginal douche of patients with cervicitis due to ureaplasma urealyticum, mycoplasma hominis, chlamydia trachomatis, neisseria gonorrhoeae and cervical erosion.


RESULTS
Compared with the control group, the level of IL-8 in vaginal douche of patients with mycoplasma hominis cervicitis, chlamydia trachomatis cervicitis and neisseria gonorrhoeae cervicitis was significantly higher and there was significant difference ng/L: 371 +/- 34, 369 +/- 31, 339 +/- 36, vs 341 +/- 32, 338 +/- 33, 316 +/- 24, (all P < 0.01). Comparing the level of IL-8 in vaginal douche of patients with ureaplasma urealyticum cervicitis and cervical erosion with that of control group, there was no statistical difference (all P > 0.05). The level of TNF-alpha in vaginal douche of each group was remarkably higher than that of control group except for patients with cervical erosion. And statistically significant difference was found between them (all P < 0.01).


CONCLUSIONS
With regards to the pathogenesis of cervicitis, local immune mechanism of vagina plays an important role in the occurrence of cervicitis. The role of IL-8 in pathogenesis of mycoplasma hominis cervicitis, chlamydia trachomatis cervicitis and neisseria gonorrhoeae cervicitis is likely to be more important.
Ning
Yu-Mei
YM
Department of Obstetrics & Gynecology, Second Affiliated Hospital, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310005, China. ningyumei1002@sina.com
Wang
Yin
Y
Lü
Ling
L
Li
Rui-Lan
RL
Liu
Chun-Juan
CJ
Jiang
Yan-Jiao
YJ
Zhu
Xiu-Zhi
XZ
D000328:Adult; D016022:Case-Control Studies; D002692:Chlamydia trachomatis; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000032:analysis*; D008875:Middle Aged; D019535:Mycoplasma hominis; D009344:Neisseria gonorrhoeae; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D016990:Ureaplasma urealyticum; D002575:Uterine Cervicitis / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*; D014621:Vagina / Q000276:immunology*; D055815:Young Adult
D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha