title: An atypical peripheral nerve sheath tumour with pseudoglandular architecture in a dog.
abstract: This case describes a subcutaneous soft tissue tumour in a German Shepherd dog. Histologically, the lesion was characterized by proliferating ovoid cells, loosely arranged in a collagenous to myxoid stroma, and by numerous pseudoglandular structures lined by neoplastic cells. Immunohistochemically, neoplastic cells were labelled with vimentin, glial fibrillary acidic protein and S100 antibodies, but not with cytokeratin, desmin and smooth muscle actin antibodies. Ultrastructurally, neoplastic cells were characterized by numerous mitochondria surrounded by endoplasmic reticulum and contained few secondary lysosomes. This tumour was diagnosed as a subcutaneous peripheral nerve sheath tumour (PNST) with pseudoglandular architecture. This case illustrates the morphological diversity of PNST and provides new insight into the differential diagnosis of cutaneous tumours of similar morphology in the dog.
authors: Department of Pathology, National Veterinary School of Alfort, 7 avenue du Général de Gaulle, 94704 Maisons-Alfort Cedex, France. c.volmer@hotmail.fr
authors: Christelle
authors: C
authors: Volmer
authors: Laura
authors: L
authors: Caplier
authors: Edouard
authors: E
authors: Reyes-Gomez
authors: Hélène
authors: H
authors: Huet
authors: Roger A
authors: RA
authors: Owen
authors: Jean-Jacques
authors: JJ
authors: Fontaine
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D046529:Microscopy, Electron, Transmission / Q000662:veterinary; D018317:Nerve Sheath Neoplasms / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*