title: Risk factors for treatment failure in orthopedic device-related methicillin-resistant Staphylococcus aureus infection.
abstract: The purpose of this study was to determine the clinical and microbiological risk factors for treatment failure of methicillin-resistant Staphylococcus aureus (MRSA) orthopedic device-related infection (ODRI). A retrospective cohort study of patients with MRSA ODRI who were treated at Geneva University Hospitals between 2000 and 2008 was undertaken. Stored MRSA isolates were retrieved for genetic characterization and determination of the vancomycin minimum inhibitory concentration (MIC). Fifty-two patients were included, of whom 23 (44%) had joint arthroplasty and 29 (56%) had osteosynthesis. All 41 of the retrieved MRSA isolates were susceptible to vancomycin (MIC <or= 2 mg/L) and 35 (85%) shared genetic characteristics of the South German clone (ST228). During a median follow-up of 391 days (range, 4-2,922 days), 18 patients (35%) experienced treatment failure involving MRSA persistence or recurrence. Microbiological factors such as infection with the predominant clone and a vancomycin MIC of 2 mg/L were not associated with treatment failure. Using a Cox proportional hazards model, implant retention (hazard ratio [HR], 4.9; 95% confidence interval [CI], 1.3-18.2; P = 0.017) and single-agent antimicrobial therapy (HR, 4.4; 95% CI, 1.2-16.3; P = 0.025) were independent predictors of treatment failure after debridement. Therapy using a combination of antimicrobials should be considered for patients with MRSA ODRI, especially when implant removal is not feasible.
authors: Infectious Diseases Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland. tristan.ferry@univ-lyon1.fr
authors: T
authors: T
authors: Ferry
authors: I
authors: I
authors: Uçkay
authors: P
authors: P
authors: Vaudaux
authors: P
authors: P
authors: François
authors: J
authors: J
authors: Schrenzel
authors: S
authors: S
authors: Harbarth
authors: F
authors: F
authors: Laurent
authors: L
authors: L
authors: Bernard
authors: F
authors: F
authors: Vandenesch
authors: J
authors: J
authors: Etienne
authors: P
authors: P
authors: Hoffmeyer
authors: D
authors: D
authors: Lew
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015373:Bacterial Typing Techniques; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000009:adverse effects; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D012189:Retrospective Studies; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013557:Switzerland; D017211:Treatment Failure; D014640:Vancomycin / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin