UV spectrophotometric method for the identification and solubility determination of nevirapine.
An UV spectrophotometric method was developed for the quantitative determination of nevirapine in water, methanol and 0.1 N HCl. It was found that qualitative determination is also possible, due to a peak-shift observed with 0.1 N HCl. The solubility at 37 degrees C, for both the anhydrous and Hemihydrated forms of nevirapine, was determined in each of the three solvents.
Stieger
N
N
North-West University, Faculty of Health Sciences, Potchefstroom, South-Africa. nicole.stieger@nwu.ac.za
Liebenberg
W
W
Wessels
J C
JC
D006851:Hydrochloric Acid; D000432:Methanol; D019829:Nevirapine / Q000032:analysis / Q000737:chemistry*; D012015:Reference Standards; D012995:Solubility; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D014867:Water
D012997:Solvents; D014867:Water; D019829:Nevirapine; D006851:Hydrochloric Acid; D000432:Methanol