Endocervical adenocarcinoma in situ with ovarian metastases: a unique variant with potential for long-term survival.
Adenocarcinoma in situ (AIS) of the endocervix is typically confined to the cervix, but may be extensive. We report 2 cases of extensive AIS-one with intraendometrial spread-that recurred after cone biopsy and were associated with ovarian metastases. In both cases, primary and metastatic tumors were positive for human papillomavirus 16. Both patients are currently disease-free and one has had no recurrence after a follow-up period of 145 months. Extensive, recurring AIS is a rare variant that may be unique for its risk of coincident ovarian involvement. However, ovarian spread, albeit rare, does not invariably result in an adverse outcome.
Chang
Martin C
MC
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Nevadunsky
Nicole S
NS
Viswanathan
Akila N
AN
Crum
Christopher P
CP
Feltmate
Colleen M
CM
D000230:Adenocarcinoma / Q000401:mortality / Q000556:secondary* / Q000821:virology; D000328:Adult; D002278:Carcinoma in Situ / Q000401:mortality / Q000473:pathology* / Q000821:virology; D005260:Female; D052162:Human papillomavirus 16; D006801:Humans; D010051:Ovarian Neoplasms / Q000401:mortality / Q000556:secondary* / Q000821:virology; D030361:Papillomavirus Infections / Q000150:complications; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology* / Q000821:virology