[Experimental study on cytochrome P450 enzymes after receiving ferment powder caterpillar fungus].
OBJECTIVE
To study the effect of ferment powder caterpillar fungus on cytochrome P450 isozymes CYP1A2, CYP3A4 and CYP2E1.


METHODS
The methods of Cocktail probe drugs were used. The rats were randomly divided into two groups. One group were given ferment powder caterpillar fungus once daily orally for ten days. Another group received orally normal saline one daily as the blank control. After ten days of treatment, the rats were given probe drugs of coffine, dapsone and chlorzoxazone and the blood was taken out by femoral catheterization. The plasma concentration of probe drugs were determined by HPLC. Data of plasma drug level-time were disposed with DAS Ver 2.0.


RESULTS
The metabolism of caffeine and dapsone speeded up after receiving ferment powder caterpillar fungus, but the metabolism of chlorzoxazone was hardly changed.


CONCLUSIONS
It suggested that ferment powder caterpillar fungus tended to be the inducer of CYP1A2 and CYP3A4. But the CYP2E1 was hardly affected.
Jia
Hai
H
The People's Hospital of Gansu Province, Lanzhou 730000, China.
Xu
Aixia
A
Yuan
Jiyong
J
Gao
Xiang
X
Gao
Jun
J
D000818:Animals; D002110:Caffeine / Q000378:metabolism; D002753:Chlorzoxazone / Q000378:metabolism; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003622:Dapsone / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005285:Fermentation; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D065607:Cytochrome P-450 Enzyme Inhibitors; D004365:Drugs, Chinese Herbal; D002110:Caffeine; D003622:Dapsone; D003577:Cytochrome P-450 Enzyme System; D002753:Chlorzoxazone