title: Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors.
abstract: A series of imidazopyrimidine derivatives with the general formula I was synthesized and identified as potent inhibitors of iNOS dimer formation, a prerequisite for proper functioning of the enzyme. Stille and Negishi coupling reactions were used as key steps to form the carbon-carbon bond connecting the imidazopyrimidine core to the central cycloalkenyl, cycloalkyl and phenyl ring templates.
authors: Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA.
authors: Guo-Hua
authors: GH
authors: Chu
authors: Bertrand
authors: B
authors: Le Bourdonnec
authors: Minghua
authors: M
authors: Gu
authors: Christopher W
authors: CW
authors: Ajello
authors: Lara K
authors: LK
authors: Leister
authors: Ian
authors: I
authors: Sellitto
authors: Joel A
authors: JA
authors: Cassel
authors: Paul A
authors: PA
authors: Tuthill
authors: Heather
authors: H
authors: O' Hare
authors: Robert N
authors: RN
authors: Dehaven
authors: Roland E
authors: RE
authors: Dolle