8-azapurine nucleus: a versatile scaffold for different targets.
-Azapurine nucleus is a bioisoster of the purine nucleus. Variously substituted 8-azapurines have been synthesised and studied for their interactions with many enzymes and receptors and for their antitumor and antiviral activity. In this paper the main results of the studies made in these last years on this topic are reported.
Giorgi
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I
Univesita di Pisa, Dipartimento di Scienze Farmaceutiche, Via Bonanno, 6-56126 Pisa - Italy. igiorgi@farm.unipi.it
Scartoni
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D000243:Adenosine Deaminase / Q000378:metabolism; D058892:Adenosine Deaminase Inhibitors; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011687:Purines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018047:Receptors, Purinergic P1 / Q000378:metabolism; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism
D058892:Adenosine Deaminase Inhibitors; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D011687:Purines; D018047:Receptors, Purinergic P1; C015008:triazolopyrimidinone; D014969:Xanthine Oxidase; D000243:Adenosine Deaminase