title: Analgesic and anticonvulsant effects of saponin isolated from the leaves of Clerodendrum infortunatum Linn. in mice.
abstract: Saponin (SN1) isolated from C. infortunatum leaves in doses of 30, 50, 75 and 100 mg/kg, ip provided 36.28, 60.47, 90.71, 100% protection respectively from writhing induced by 1.2% v/v acetic acid. In hot plate method, SN1 not only produced analgesia in mice but also potentiated the analgesic action of pentazocine and aspirin. The anticonvulsant activity was tested by leptazol-induced seizures. SN1 decreased the duration of seizures and gave protection in a dose dependent manner against leptazol-induced convulsions. The results suggest that saponin has significant analgesic and anticonvulsant effects.
authors: Natural Products Research Laboratory, Department of Pharmaceutical Chemistry, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj 757 086, Orissa, India. drdilip2003@yahoo.co.in
authors: Dilipkumar
authors: D
authors: Pal
authors: Santanu
authors: S
authors: Sannigrahi
authors: Upal Kanti
authors: UK
authors: Mazumder
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D032409:Clerodendrum; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry*; D012503:Saponins / Q000627:therapeutic use*; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D010936:Plant Extracts; D012503:Saponins