title: The utility of delayed-enhancement magnetic resonance imaging for identifying nonischemic myocardial fibrosis in asymptomatic patients with biopsy-proven systemic sarcoidosis.
abstract: BACKGROUND
  The pathophysiology of sarcoidosis includes infiltrative inflammatory injury, as well as interstitial fibrosis formation. Delayed-enhancement (DE) magnetic resonance imaging (MRI) techniques have been shown to identify fibrotic tissue as areas of hyperenhancement. To test the hypothesis that DE-MRI can be used to identify myocardial fibrosis resulting from cardiac sarcoidosis, we assessed this method in asymptomatic patients with biopsy-proven systemic sarcoidosis.
  
  
  METHODS
  Thirty-one patients with biopsy-confirmed systemic sarcoidosis and no known history of heart disease or sarcoid cardiac involvement underwent DE-MRI after gadolinium-chelate administration. The location and extent of DE were quantified by 2 radiologists experienced at evaluating cardiovascular MRI images.
  
  
  RESULTS
  According to DE-MRI, 8 (26%) of the 31 patients had nonischemic fibrosis, as evidenced by abnormal DE patterns. Unlike characteristic ischemic injuries, most of the fibrosis was mid-myocardial, extending to the adjacent endocardium, epicardium, or both. The most frequent site of fibrosis was the basal inferoseptum, followed by the basal inferolateral wall.
  
  
  CONCLUSIONS
  In asymptomatic patients with systemic sarcoidosis, DE-MRI may provide a novel, noninvasive method for the early identification of myocardial fibrosis.
authors: Department of Radiology, Texas Heart Institute at St. Luke's Episcopal Hospital, Houston, Texas 77030, USA. bcheong@sleh.com
authors: B Y C
authors: BY
authors: Cheong
authors: R
authors: R
authors: Muthupillai
authors: M
authors: M
authors: Nemeth
authors: B
authors: B
authors: Lambert
authors: D
authors: D
authors: Dees
authors: S
authors: S
authors: Huber
authors: R
authors: R
authors: Castriotta
authors: S D
authors: SD
authors: Flamm
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D009202:Cardiomyopathies / Q000473:pathology*; D003287:Contrast Media; D042241:Early Diagnosis; D004699:Endocardium / Q000473:pathology; D005260:Female; D005355:Fibrosis; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D009942:Organometallic Compounds; D010496:Pericardium / Q000473:pathology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012507:Sarcoidosis / Q000473:pathology*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C112666:gadoversetamide