Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity.
Mechanisms by which whole chromosome instability lead to tumorigenesis have eluded the cancer research field. In this issue of Cancer Cell, Baker et al. show that CIN induced by a defective mitotic checkpoint, under certain genetic and tissue contexts, leads to accelerated loss of heterozygosity of a tumor suppressor gene.
Sotillo
Rocio
R
Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Schvartzman
Juan-Manuel
JM
Benezra
Robert
R
D043171:Chromosomal Instability; D016147:Genes, Tumor Suppressor; D006801:Humans; D019656:Loss of Heterozygosity