Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice.
Recent studies point out the important role of IGF and insulin-related signaling pathways in the control of longevity of laboratory animals. The Ames dwarf mouse is a murine model of circulating GH and IGF-1 deficiency that exhibits dwarf phenotype characteristics and significantly extends lifespan. It is interesting to know that Ames dwarf mice do not experience an age-related decline in cognitive function when compared to their young counterparts. In this study, the most recent works on local GH and IGF-1 expression in the hippocampus of Ames mice are briefly reviewed.
Sun
Liou Y
LY
Department of Pediatrics, Division of Endocrinology, University of North Carolina at Chapel Hill, Campus Box #7039 , 3341 MBRB, Chapel Hill, North Carolina 27599-7039, USA. leeosun@gmail.com