title: Regulation of bone formation and immune cell development by Schnurri proteins.
abstract: Although identified over a decade ago, the function and physiological significance of the mammalian Schnurri protein family remained largely unknown. However, the recent generation and characterization of mice bearing null mutations in the individual Schnurri genes has led to the discovery of unexpected yet central roles for these large zinc-finger proteins in several biological processes. Here, we review findings of these studies and discuss the importance of the Schnurri protein family in regulating both the immune and skeletal systems.
authors: Department of Infectious Disease and Immunology, Harvard School of Public Health, Boston, MA, USA. djones@hsph.harvard.edu
authors: Dallas C
authors: DC
authors: Jones
authors: Laurie H
authors: LH
authors: Glimcher
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D007107:Immune System / Q000166:cytology* / Q000378:metabolism*; D010012:Osteogenesis
chemical_list: D004268:DNA-Binding Proteins