title: [Compound huangdai tablet as induction therapy for 193 patients with acute promyelocytic leukemia].
abstract: OBJECTIVE
  To report the results of curative and adverse effects of compound huangdai tablet (CHDT) as induction therapy for 193 patients with acute promyelocytic leukemia (APL).
  
  
  METHODS
  CHDT was administered 1.25 g orally three times a day after meal for three days, then the dosage was gradually increased to 7.5 g/d.
  
  
  RESULTS
  One hundred and ninety-three patients achieved complete remission (CR), 78.8% of whom in 30 to 60 days with an average time of 44.3 d. No serious infection, bleeding or DIC occurred during the treatment course. The major adverse effects were gastrointestinal symptoms. There was no change in lanine transaminase, urea, creatinine or electrocardiographic QTc interval in 110 APL patients observed before and after the treatment.
  
  
  CONCLUSIONS
  CHDT therapy is a modality of higher CR rate, good safety and tolerance without bone marrow suppression for APL patients.
authors: Department of Traditional Chinese Medicine & Hematology, 210th Hospital of PLA, Dalian 116021, China.
authors: Yang
authors: Y
authors: Xiang
authors: Xiao-Bo
authors: XB
authors: Wang
authors: Shu-Jun
authors: SJ
authors: Sun
authors: Ai-Xia
authors: AX
authors: Guo
authors: Ai-Hong
authors: AH
authors: Wei
authors: Yu-Bin
authors: YB
authors: Cheng
authors: Shi-Lin
authors: SL
authors: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy / Q000009:adverse effects; D028321:Plant Preparations / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D028321:Plant Preparations