Integrin signaling aberrations in prostate cancer.
Integrins are cell surface receptors for extracellular matrix proteins and play a key role in cell survival, proliferation, migration and gene expression. Integrin signaling has been shown to be deregulated in several types of cancer, including prostate cancer. This review is focused on integrin signaling pathways known to be deregulated in prostate cancer and known to promote prostate cancer progression.
Goel
Hira Lal
HL
Department of Cancer Biology, Prostate Cancer Discovery and Development Program, Cancer Center, University of Massachusetts Medical School Worcester, MA 01605, USA.
Alam
Naved
N
Johnson
Isaac N S
IN
Languino
Lucia R
LR