[Regulation of human dendrite cells' physiological functions with the recombinant heat shock protein Hsp70].
Reference literature review. The dendrite cells (DC) are the most important antigen-representing cells of the organism. They are the target for various vaccines, and on the basis of the DC cellular anti-tumour and anti-viral vaccines (DC vaccines) have been developed. At the same time, the DC can be a convenient model for studying activity and action mechanisms of different immune-therapeutic preparations. One of the aspects of the DC use optimization for induction of antigen-specific immune response might involve use of the heat shock proteins (Hsp), the Hsp70 in particular. This protein can be used for administration of protein antigens into the DC and for regulation of the DC activity. Knowledge of the DC physiology and specifics of interrelationship among the Hsp70 and its complexes with the DC antigens of different differentiation degree is an important aspect for implementation of these ideas. Human Hsp70 has been shown both to bring antigens to the DC and to regulate activity of the DC as well as to optimize induction of antigen-specific cellular immune response.
Pal'tsev
M A
MA
Severin
S E
SE
Danilevskiĭ
M I
MI
Moskaleva
E Iu
EIu
D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology* / Q000494:pharmacology; D003713:Dendritic Cells / Q000276:immunology*; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology* / Q000494:pharmacology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000502:physiology; D011994:Recombinant Proteins / Q000276:immunology* / Q000494:pharmacology; D014765:Viral Vaccines / Q000276:immunology* / Q000494:pharmacology
D019496:Cancer Vaccines; D018840:HSP70 Heat-Shock Proteins; D011994:Recombinant Proteins; D014765:Viral Vaccines