[Advances in the researches of spermatogenic protein, Ropporin].
Ropporin has been identified as a spermatogenic cell-specific protein and may be involved in sperm maturation, motility, capacitation, hyperactivation and acrosome reaction. However, latest studies have shown that Ropporin is expressed weakly in normal non-testis tissues and highly in hematologic malignancies. Its highly conservative expression in mammalians demonstrates its importance to life. This paper updates the characterization, expression and its distribution, and biological function of Ropporin, and the advances in the clinical researches of the protein.
Chen
Jing
J
Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China. gzchenjing@yahoo.com.cn
Cai
Zhi-ming
ZM
Gui
Yao-ting
YT
D000818:Animals; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000502:physiology*; D013091:Spermatogenesis; D020741:rho GTP-Binding Proteins / Q000502:physiology*
D008565:Membrane Proteins; C404565:ROPN1 protein, human; D020741:rho GTP-Binding Proteins