title: Secondhand smoke exposure and depressive symptoms.
abstract: OBJECTIVE
  To evaluate the association between secondhand smoke (SHS) exposure and depression. Tobacco smoking and depression are strongly associated, but the possible effects of SHS have not been evaluated.
  
  
  METHODS
  The 2005 to 2006 National Health and Nutrition Examination Survey (NHANES) is a cross-sectional sample of the noninstitutionalized civilian U.S. population. SHS exposure was measured in adults aged > or =20 years by serum cotinine and depressive symptoms by the Patient Health Questionnaire. Zero-inflated Poisson regression analyses were completed with adjustment for survey design and potential confounders.
  
  
  RESULTS
  Serum cotinine-documented SHS exposure was positively associated with depressive symptoms in never-smokers, even after adjustment for age, race/ethnicity, gender, education, alcohol consumption, and medical comorbidities. The association between SHS exposure and depressive symptoms did not vary by gender, nor was there any association between SHS smoke exposure and depressive symptoms in former smokers.
  
  
  CONCLUSIONS
  Findings from the present study suggest that SHS exposure is positively associated with depressive symptoms in never-smokers and highlight the need for further research to establish the mechanisms of association.
authors: Department of Epidemiology and Public Health, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
authors: Frank C
authors: FC
authors: Bandiera
authors: Kristopher L
authors: KL
authors: Arheart
authors: Alberto J
authors: AJ
authors: Caban-Martinez
authors: Lora E
authors: LE
authors: Fleming
authors: Kathryn
authors: K
authors: McCollister
authors: Noella A
authors: NA
authors: Dietz
authors: William G
authors: WG
authors: Leblanc
authors: Evelyn P
authors: EP
authors: Davila
authors: John E
authors: JE
authors: Lewis
authors: Berrin
authors: B
authors: Serdar
authors: David J
authors: DJ
authors: Lee
mesh_terms: D016902:Air Pollution, Indoor / Q000009:adverse effects; D002908:Chronic Disease; D003367:Cotinine / Q000097:blood; D003863:Depression / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D003865:Major Depressive Disorder / Q000097:blood / Q000201:enzymology / Q000453:epidemiology; D004781:Environmental Exposure; D005260:Female; D006291:Health Policy; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires; D014028:Tobacco Smoke Pollution / Q000009:adverse effects* / Q000706:statistics & numerical data; D014481:United States / Q000453:epidemiology; D017132:Workplace / Q000706:statistics & numerical data; D005680:gamma-Aminobutyric Acid / Q000097:blood
chemical_list: D014028:Tobacco Smoke Pollution; D005680:gamma-Aminobutyric Acid; D003367:Cotinine