title: ESR and electrochemical study of 1,2-disubstituted 5-nitroindazolin-3-ones and 2-substituted 3-alkoxy-5-nitro-2H-indazoles: reactivity and free radical production capacity in the presence of biological systems.
abstract: Two families of 5-nitroindazole derivatives were electrochemically studied in an aprotic solvent using cyclic voltammetry (CV) technique. The produced nitro-anion radical species were characterized using electron spin resonance spectroscopy (ESR). Also, we examined the interaction between the radical species generated from nitroindazole derivatives and glutathione (GSH). Moreover, the capacity of intraparasite and intramammals-free radical production, through ESR spectroscopy, was performed.
authors: Departamento de Química Inorgánica y Analítica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.
authors: Christian
authors: C
authors: Folch-Cano
authors: Claudio
authors: C
authors: Olea-Azar
authors: Vicente J
authors: VJ
authors: Arán
authors: Christian
authors: C
authors: Diaz-Urrutia
mesh_terms: D000818:Animals; D000838:Anions / Q000737:chemistry; D004563:Electrochemistry / Q000379:methods*; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D005609:Free Radicals / Q000737:chemistry; D005978:Glutathione / Q000737:chemistry; D006801:Humans; D007191:Indazoles / Q000737:chemistry* / Q000494:pharmacology; D008861:Microsomes / Q000187:drug effects; D015394:Molecular Structure; D010084:Oxidation-Reduction; D026361:Reactive Nitrogen Species / Q000737:chemistry; D014349:Trypanosoma cruzi / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
chemical_list: D000838:Anions; D005609:Free Radicals; D007191:Indazoles; D026361:Reactive Nitrogen Species; C530840:5-nitroindazole; D005978:Glutathione