title: Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships.
abstract: The gram-scale isolation of the major flavonolignan diastereoisomers from milk thistle ( Silybum marianum) extract provided an entree into the isolation of two related analogues that are present in extremely minute quantities. The isolation and structure elucidation of these two new compounds, which we have termed isosilybin C and isosilybin D due to their structural similarities to isosilybin A and isosilybin B, respectively, afforded a preliminary analysis of structure-activity relationships toward prostate cancer growth, survival, and apoptotic endpoints.
authors: Natural Products Laboratory, Research Triangle Institute, Research Triangle Park, North Carolina, USA.
authors: Arlene
authors: A
authors: Sy-Cordero
authors: Tyler N
authors: TN
authors: Graf
authors: Yuka
authors: Y
authors: Nakanishi
authors: Mansukh C
authors: MC
authors: Wani
authors: Rajesh
authors: R
authors: Agarwal
authors: David J
authors: DJ
authors: Kroll
authors: Nicholas H
authors: NH
authors: Oberlies
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D044947:Flavonolignans / Q000737:chemistry*; D006801:Humans; D008297:Male; D020944:Silybum marianum / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D011471:Prostatic Neoplasms; D012838:Silymarin / Q000031:analogs & derivatives* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D044947:Flavonolignans; D010936:Plant Extracts; D012838:Silymarin; C523198:isosilybin A