Longitudinal analysis of the depressive effects of intravenous amiodarone on depolarization and repolarization: a case report.
Intravenous amiodarone (AMD) induces multiple antiarrhythmic effects via blocking of Na(+), Ca(2+), and IKr channels, and beta receptors. A patient on chronic dialysis was administered AMD for nonsustained ventricular tachycardia after successful cardiopulmonary resuscitation. QT prolongation occurred 5 h after AMD administration. AMD was withdrawn at 24 h because of prolonged QTc interval (716 ms), which persisted for a further 48 h (661 ms). Ventricular premature contraction (VPC) was significantly decreased at 7h; however, VPC increased again after discontinuing AMD. Depolarization changes induced by the Na(+)-channel blocking action of AMD were analyzed. There was increasing filtered QRS-duration and duration of low-amplitude signals at voltage <40 µV, and decreasing root-mean-square voltage of signals in the last 40 ms of ventricular late potentials (LPs) within 7 h. However after stopping AMD, LPs were reversed. The blood concentration of AMD reached the effective level within 10 min but decreased immediately to an ineffective level. Onset and disappearance of the VPC-inhibiting effect corresponded to the depressive effect on depolarization but not with the increase in the prolonged repolarization effect and blood concentration. Even if the QT interval is sufficiently prolonged, the Na(+)-channel blocking action is required for AMD to induce the antiarrhythmic effect.
Yoshioka
Koichiro
K
Department of Cardiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Kanagawa, Japan. ko1@is.icc.u-tokai.ac.jp
Amino
Mari
M
Matsuzaki
Atsushi
A
Shima
Makiyoshi
M
Fujii
Toshiharu
T
Kanda
Shigetaka
S
Deguchi
Yoshiaki
Y
Kodama
Itsuo
I
Tanabe
Teruhisa
T
D000638:Amiodarone / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D016887:Cardiopulmonary Resuscitation; D003864:Depression, Chemical; D015716:Electrocardiography, Ambulatory; D006801:Humans; D007262:Infusions, Intravenous; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D026941:Sodium Channel Blockers; D017180:Tachycardia, Ventricular / Q000503:physiopathology* / Q000628:therapy*; D013997:Time Factors; D016276:Ventricular Function / Q000187:drug effects
D000889:Anti-Arrhythmia Agents; D026941:Sodium Channel Blockers; D000638:Amiodarone