Mathematical modeling of triamcinolone acetonide drug release from the I-vation intravitreal implant (a controlled release platform).
In-vitro drug release of triamcinolone acetonide from the I-vation implant can be controlled and tuned by varying its formulation ingredients. These release characteristics can be modeled using a parabolic partial differential equation to describe one dimensional Fickian drug diffusion in a durable polymer matrix.
Barnett
Peter J
PJ
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003198:Computer Simulation; D016503:Drug Delivery Systems; D015195:Drug Design; D004867:Equipment Design; D015818:Eye Infections, Bacterial / Q000188:drug therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008962:Models, Theoretical; D011108:Polymers / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*; D014822:Vitreous Body / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D011108:Polymers; D014222:Triamcinolone Acetonide