Modulation of arousal regulation with central thalamic deep brain stimulation.
To investigate the effects of central thalamic deep brain stimulation (CT/DBS) on behavior and frontal cortical function, we conducted experiments in an awake, behaving macaque monkey performing tasks that required sustained attention and working memory. Results of this preliminary study revealed that CT/DBS can lead to an improvement, a decrement, a mixed or have no effect on behavior.
Shah
Sudhin A
SA
Physiology, Biophysics and Systems Biology Department, Weill Cornell Graduate School of Biomedical Sciences, NY, NY 10021, USA. sut2006@med.cornell.edu
Baker
Jonathan L
JL
Ryou
Jae-Wook
JW
Purpura
Keith P
KP
Schiff
Nicholas D
ND
D000328:Adult; D000818:Animals; D001143:Arousal; D001288:Attention; D001519:Behavior; D001522:Behavior, Animal; D001921:Brain / Q000473:pathology*; D046690:Deep Brain Stimulation / Q000379:methods*; D004594:Electrophysiology / Q000379:methods; D006801:Humans; D008251:Macaca; D008297:Male; D008570:Memory, Short-Term; D009434:Neural Pathways; D009474:Neurons / Q000473:pathology