title: Stereotactic spine radiosurgery for intradural and intramedullary metastasis.
abstract: OBJECTIVE
  Stereotactic radiosurgery (SRS) has become an important treatment alternative to surgery for a variety of spinal lesions. However, the use of SRS in the management of intradural intramedullary (IDIM) metastasis remains controversial. The aim of this study was to determine the clinical efficacy and safety of SRS for treatment of IDIM metastasis.
  
  
  METHODS
  Nine patients with 11 IDIM metastases treated with SRS at Henry Ford Hospital were retrospectively reviewed. The mean age at presentation was 50 years, with a range of 14-71 years. There were 4 intradural extramedullary and 7 intramedullary lesions. The radiosurgery procedure used techniques of image-guided and intensitymodulated radiation. The mean treatment dose was 13.8 Gy, with a range of 10-16 Gy. All patients had clinical follow-up (except in 1 lesion), with an emphasis on initial symptoms and ambulatory status, and 8 patients (9 lesions) had imaging studies. The median follow-up duration was 10 months.
  
  
  RESULTS
  The presenting symptoms were improved in 8 (80%) of 10 evaluable lesions, unchanged in 1 case, and worsened in 1 case. Radiographic responses were seen as follows: complete response in 2 (22%) of 9; partial response in 3 (33%) of 9; stable disease in 3 (33%) of 9; and progressive disease in 1 (11%) of 9. After radiosurgery, 7 patients (78%) remained ambulatory until the last follow-up visit. The overall median survival time after SRS was 8 months, with a range of 2-19 months. No radiation toxicity was detected clinically during the follow-up period.
  
  
  CONCLUSIONS
  Despite the fact that this was a small series of patients with IDIM metastasis who had limited treatment options, SRS appears to be an effective and safe method of treating patients with these lesions.
authors: Department of Neurosurgery, CHA University, Pochon, Republic of Korea.
authors: Dong Ah
authors: DA
authors: Shin
authors: Ryoong
authors: R
authors: Huh
authors: Sang Sup
authors: SS
authors: Chung
authors: Jack
authors: J
authors: Rock
authors: Samuel
authors: S
authors: Ryu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology; D004388:Dura Mater / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D016634:Radiosurgery / Q000379:methods*; D013120:Spinal Cord Neoplasms; D013125:Spinal Neoplasms / Q000556:secondary* / Q000601:surgery*; D016896:Treatment Outcome