Hippocampal damage produces retrograde but not anterograde amnesia for a cued location in a spontaneous exploratory task in rats.
Performance in several memory tasks is known to be unaffected by hippocampal damage sustained before learning, but is severely disrupted if the same damage occurs after learning. Memories for preferred locations, or home bases, in exploratory tasks can be formed by rats with hippocampal damage, but it is unknown if the memory for a home base survives hippocampal damage. To examine this question, for 30 min each day for five consecutive days, rats explored a circular open field containing one local cue. By Day 5 the rats preferentially went directly to that location, spent the majority of their time at that location, made rapid direct trips to that location when returning from an excursion and so demonstrated that the location was a home base. Memory for the cued location was examined after a 24 h or 14-day interval with the cue removed. In Experiments 1 and 2, control rats and rats with prior N-methyl-D-aspartic acid hippocampal lesions demonstrated memory of the home base location by making direct trips to that location. In Experiment 3, rats that had first explored the open field and cue and then received hippocampal lesions showed no memory for the cued location. The absence of anterograde impairment vs. the presence of retrograde impairment for memory of a spatial home base confirms a role for the hippocampus in the retention of spatial memory acquired during exploration.
Travis
Scott G
SG
Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
Sparks
Fraser T
FT
Arnold
Tyrell
T
Lehmann
Hugo
H
Sutherland
Robert J
RJ
Whishaw
Ian Q
IQ
D020324:Amnesia, Anterograde / Q000209:etiology* / Q000473:pathology*; D000648:Amnesia, Retrograde / Q000209:etiology* / Q000473:pathology*; D000818:Animals; D001925:Brain Damage, Chronic / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D003463:Cues; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000502:physiology*; D006624:Hippocampus / Q000473:pathology*; D008569:Memory Disorders / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar