Taste memory trace disruption by AP5 administration in basolateral amygdala.
N-methyl-D-aspartate receptor has been related to learning and memory processes. Its characteristics make it a key candidate in the modulation of associative processes at physiological level. Traditionally, the main efforts have been directed to show its role in excitatory conditioning. Nevertheless, the studies that have analyzed its implication in inhibitory learning are scarce. We present an experiment where a preexposure effect on the conditioning (latent inhibition) is disrupted by 2-amino-5-phosphonopentanoic acid administered in basolateral amygdala. This data shows interference on taste memory trace, and attenuation of the inhibition effect.
Traverso
Luis Miguel
LM
Department of Experimental Psychology, Lab Neurociencia de la Conducta, University of Seville, Spain.
Quintero
Esperanza
E
Vargas
Juan Pedro
JP
De la Casa
Luis Gonzalo
LG
Lopez
Juan Carlos
JC
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology*; D000679:Amygdala / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D001245:Association Learning / Q000187:drug effects / Q000502:physiology; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005108:Extinction, Psychological / Q000187:drug effects / Q000502:physiology; D018698:Glutamic Acid / Q000378:metabolism; D007266:Inhibition, Psychological; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D008569:Memory Disorders / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D009483:Neuropsychological Tests; D051381:Rats; D017208:Rats, Wistar; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D055697:Taste Perception / Q000187:drug effects* / Q000502:physiology
D018691:Excitatory Amino Acid Antagonists; D018698:Glutamic Acid; D015763:2-Amino-5-phosphonovalerate