In vitro adsorption of gentamicin and netilmicin by polyacrylonitrile and polyamide hemofiltration filters.
Adsorption of gentamicin and netilmicin by new polyacrylonitrile and polyamide hemofiltration filters was studied over 4 h, using a single-compartment in vitro continuous venovenous hemofiltration model. After the first dose (16.6 mg of gentamicin, 19.3 mg of netilmicin), 14.9 mg of gentamicin and 19.2 mg of netilmicin were adsorbed to polyacrylonitrile filters in vitro. Adsorption by polyacrylonitrile filters was rapid and irreversible and could be increased by repeated dosing. Adsorption by polyamide filters was substantially less.
K N Lam
Philip
P
Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T., Hong Kong.
Tian
Qi
Q
Ip
Margaret
M
Gomersall
Charles D
CD
D000180:Acrylic Resins / Q000737:chemistry*; D000327:Adsorption; D005839:Gentamicins / Q000737:chemistry*; D006440:Hemofiltration / Q000295:instrumentation*; D008567:Membranes, Artificial; D009428:Netilmicin / Q000737:chemistry*; D009757:Nylons / Q000737:chemistry*
D000180:Acrylic Resins; D005839:Gentamicins; D008567:Membranes, Artificial; D009757:Nylons; C010504:polyacrylonitrile; D009428:Netilmicin