Aesthetic cardiology: adipose-derived stem cells for myocardial repair.
Stem cell biology has increasingly gained scientific and public interest in recent years. In particular, the use of stem cells for treatment of heart disease has been strongly pursued within the scientific and medical communities. Significant effort has gone into the use of adult tissue-derived stem cells for cardiac repair including bone marrow, blood, and cardiac-derived cell populations. Significant interest in this area has been balanced by the difficulties of understanding stem cells, cardiac injury, and the amalgamation of these areas of investigation in translational medicine. Recent studies have emerged on adipose-derived stem cells which show the potential for cardiac lineage development in vitro and may have application in cell-mediated in vivo therapy for the diseased heart. This review provides a summary of current findings within the field of adipose-derived stem cell biology regarding their cardiac differentiation potential.
Palpant
Nathan J
NJ
Department of Integrative Biology & Physiology, University of Minnesota Medical School, 6-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA.
Metzger
Joseph M
JM
D000273:Adipose Tissue / Q000473:pathology*; D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D054338:Cell Transdifferentiation; D048091:Guided Tissue Regeneration; D006331:Heart Diseases / Q000473:pathology / Q000628:therapy*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000473:pathology; D055153:Stem Cell Niche / Q000473:pathology*; D033581:Stem Cell Transplantation; D023822:Tissue Engineering