[Preparation and properties of novel human-like collagen-silk fibroin scaffold for blood vessel].
In order to improve tensile property of vascular scaffold, we blended silk fibroin with novel human-like collagen with the mass ratio of 9:1, 7:3 and 5:5 (W/W), and then fabricated blood vessel tubular graft by freeze-drying process. We studied microstructure, mechanical properties, elements composites, degradability and biocompatibility of vascular scaffolds. These results showed that tubular scaffold with mass ratio 7:3 exhibited interconnected porous structure with pore size at (60 +/- 5) microm and porosity of 85%; achieved the desirable mechanical property (strain of 50% +/- 5% and stress of 332 +/- 16 kPa); had relatively slow degradation rate; could enhance cell adhesion and proliferation and had superior biocompatibility.
Zhu
Chenhui
C
Shaanxi Key Laboratory of Degradable Biomedical Materials, Northwest University, Xi'an 710069, China.
Fan
Daidi
D
Ma
Xiaoxuan
X
Xue
Wenjiao
W
Hui
Junfeng
J
Chen
Lan
L
Duan
Zhiguang
Z
Ma
Pu
P
D001672:Biocompatible Materials / Q000737:chemistry; D001696:Biomechanical Phenomena; D001808:Blood Vessels / Q000502:physiology*; D003094:Collagen / Q000737:chemistry*; D005349:Fibroins / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D016062:Porosity; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds
D001672:Biocompatible Materials; D003094:Collagen; D005349:Fibroins