Management of newly diagnosed symptomatic multiple myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus guidelines.
Multiple myeloma is a malignant plasma cell neoplasm that affects more than 20,000 people each year and is the second most common hematologic malignancy. It is part of a spectrum of monoclonal plasma cell disorders, many of which do not require active therapy. During the past decade, considerable progress has been made in our understanding of the disease process and factors that influence outcome, along with development of new drugs that are highly effective in controlling the disease and prolonging survival without compromising quality of life. Identification of well-defined and reproducible prognostic factors and introduction of new therapies with unique modes of action and impact on disease outcome have for the first time opened up the opportunity to develop risk-adapted strategies for managing this disease. Although these risk-adapted strategies have not been prospectively validated, enough evidence can be gathered from existing randomized trials, subgroup analyses, and retrospective studies to develop a working framework. This set of recommendations represents such an effort-the development of a set of consensus guidelines by a group of experts to manage patients with newly diagnosed disease based on an interpretation of the best available evidence.
Kumar
Shaji K
SK
Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. kumar.shaji@mayo.edu
Mikhael
Joseph R
JR
Buadi
Francis K
FK
Dingli
David
D
Dispenzieri
Angela
A
Fonseca
Rafael
R
Gertz
Morie A
MA
Greipp
Philip R
PR
Hayman
Suzanne R
SR
Kyle
Robert A
RA
Lacy
Martha Q
MQ
Lust
John A
JA
Reeder
Craig B
CB
Roy
Vivek
V
Russell
Stephen J
SJ
Short
Kristen E Detweiler
KE
Stewart
A Keith
AK
Witzig
Thomas E
TE
Zeldenrust
Steven R
SR
Dalton
Robert J
RJ
Rajkumar
S Vincent
SV
Bergsagel
P Leif
PL
D000971:Antineoplastic Combined Chemotherapy Protocols; D014408:Biomarkers, Tumor / Q000235:genetics; D006801:Humans; D009101:Multiple Myeloma / Q000473:pathology / Q000628:therapy*; D017410:Practice Guidelines as Topic; D018570:Risk Assessment; D033581:Stem Cell Transplantation
D014408:Biomarkers, Tumor