title: The Relationship between Changes in Weight Status and Insulin Resistance in Youth.
abstract: This study examined changes in insulin resistance (IR) in 120 youth over two years. IR was quantified via homeostatic model (HOMA-IR), and weight status changes were quantified via body mass index (BMI). When all participants were considered, the mean HOMA-IR and BMI increased 13.4% and 1.65 units, respectively. Change in BMI z-score and percent change in HOMA-IR were moderately associated (r = 0.39). Follow-up analyses were performed for the following weight groups: NN (normal at baseline and two years later), NO (normal to overweight), ON (overweight to normal), and OO (overweight at both points). The NO group had a greater change in HOMA-IR (+50%) compared to other groups: ON (-8%), NN (+2%), and OO (-0.1%) (P < .05). The association between changes in BMI z-score and HOMA-IR was r = 0.49 when only the NO and ON groups were included. These results reinforce the importance of preventing youth from becoming overweight to control IR.
authors: Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, 209 Fetzer Gym CB# 8700, Chapel Hill, NC 27599, USA.
authors: Kristin S
authors: KS
authors: Ondrak
authors: Robert G
authors: RG
authors: McMurray
authors: Claudio L
authors: CL
authors: Battaglini
authors: Kelly R
authors: KR
authors: Evenson
authors: Joanne S
authors: JS
authors: Harrell