title: Assessment of synchronization measures for effective ventricular support by using the shape memory alloy fibred artificial myocardium in goats.
abstract: Thromboembolic and haemorrhagic complications are the primary causes of mortality and morbidity in patients with artificial hearts, which are known to be induced by the interactions between blood flow and artificial material surfaces. The authors have been developing a new mechanical artificial myocardial assist device by using a sophisticated shape memory alloy fibre in order to achieve the mechanical cardiac support from outside of the heart without a direct blood contacting surface. The original material employed as the actuator of artificial myocardial assist devices was 100um fibred-shaped, which was composed of covalent and metallic bonding structure and designed to generate 4-7 % shortening by Joule heating induced by the electric current input. In this study, we focused on the synchronization of the actuator with native cardiac function, and the phase delay parameter was examined in animal experiments using Saanen goats. Total weight of the device including the actuator was around 150g, and the electric power was supplied transcutaneously. The device could be successfully installed into thoracic cavity, which was able to be girdling the left ventricle. The contraction of the device could be controlled by the originally designed microcomputer. The mechanical contraction signal input had been transmitted with the phase delay of 50-200 msec after the R-wave of ECG, and hemodynamic changes were investigated. Cardiac output and systolic left ventricular pressure were elevated with 20% delay of cardiac cycle by 27% and 7%, respectively, although there was smaller difference under the condition of the delay of over 30%. Therefore, it was suggested that the synchronization measures should be examined in order to achieve sophisticated ventricular passive/active support on physiological demand.
authors: Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
authors: Y
authors: Y
authors: Shiraishi
authors: T
authors: T
authors: Yambe
authors: Y
authors: Y
authors: Saijo
authors: F
authors: F
authors: Sato
authors: A
authors: A
authors: Tanaka
authors: M
authors: M
authors: Yoshizawa
authors: T K
authors: TK
authors: Sugai
authors: Y
authors: Y
authors: Kaneko
authors: Y
authors: Y
authors: Sato
authors: M
authors: M
authors: Uematsu
authors: M
authors: M
authors: Umezu
authors: T
authors: T
authors: Fujimoto
authors: N
authors: N
authors: Masumoto
authors: H
authors: H
authors: Liu
authors: A
authors: A
authors: Baba
authors: S
authors: S
authors: Konno
authors: K
authors: K
authors: Tabayashi
authors: H
authors: H
authors: Sasada
authors: D
authors: D
authors: Homma
mesh_terms: D000497:Alloys; D000818:Animals; D005260:Female; D006041:Goats; D006339:Heart Rate; D006354:Heart, Artificial; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006470:Hemorrhage / Q000503:physiopathology; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D009206:Myocardium / Q000473:pathology*; D011474:Prosthesis Design; D011673:Pulsatile Flow / Q000502:physiology; D013923:Thromboembolism / Q000503:physiopathology
chemical_list: D000497:Alloys