title: [Pharmacokinetics and bioavailability of cantharidin in beagle dogs].
abstract: OBJECTIVE
  To study the pharmacokinetics and bioavailability of cantharidin in beagle dogs to evaluate the pharmacokinetic parameters and bioavailability of cantharidin in beagle dogs by determining dose-time curve and by comparing with the pharmacokinetics of cantharidin injection.
  
  
  METHODS
  Six beagle dogs, after protein precipitation by hydrochloric acid, ethyl acetate was applied to extract cantharidin from plasma The plasma concentration of cantharidin in beagle dogs was determined by GC-MS. The WinNonLin program was used to calculate the pharmacokinetic parameters and bioavailability.
  
  
  RESULTS
  The main pharmacokinetic parameters of cantharidin by iv in dogs (34 mL x h(-1) x kg(-1)) were AUC (203.5 +/- 23.8) h x microg x L(-1), CL (168.8 +/- 18.6) mL x h(-1) x kg(-1), t1/2 (0.69 +/- 0.03) h. The main pharmacokinetic parameters of cantharidin by op (102 microg x kg(-1)) were: AUC (160.4 +/- 26.9) h x microg x L(-1), CL (649.1 +/- 97.7) mL x h(-1) x kg(-1), t1/2 (0.38 +/- 0.1) h., F (bioavailability) = 26.7% comparing to injection.
  
  
  CONCLUSIONS
  As compared with cantharidin injection, the absorption of catharidin by op is poor and the bioavailability is also low, indicating that enhancement of the bioavailability will be beneficial to the clinical application.
authors: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100093, China.
authors: Yunjie
authors: Y
authors: Dang
authors: Chunyan
authors: C
authors: Zhu
mesh_terms: D000818:Animals; D001682:Biological Availability; D002193:Cantharidin / Q000493:pharmacokinetics*; D001517:Coleoptera / Q000737:chemistry*; D004285:Dogs; D008297:Male; D023421:Models, Animal
chemical_list: D002193:Cantharidin