title: Discordance in nuchal translucency measurements in monochorionic diamniotic twins as predictor of twin-to-twin transfusion syndrome.
abstract: OBJECTIVE
  Discordance in nuchal translucency measurements in monochorionic diamniotic twin pregnancies was assessed as predictor of Twin-to-Twin Transfusion Syndrome.
  
  
  METHODS
  A total of 61 monochorionic diamniotic twins were enrolled. Nuchal translucency (NT) and crown-rump-length (CRL) discordance was calculated as the percentage of delta NT and CRL (absolute difference NT/CRL fetus 1 and fetus 2) of the largest measurement, and correlated with subsequent development of Twin-to-Twin Transfusion Syndrome.
  
  
  RESULTS
  Twin-to-Twin Transfusion Syndrome developed in 14/61 (23%) of cases. A NT discordance of 20% or more best predicted Twin-to-Twin Transfusion Syndrome development, with a sensitivity of 64% and a specificity of 78%. We found a positive predictive value of 50% and negative predicted value of 86% for Twin-to-Twin Transfusion Syndrome development if NT discordance was 20% or more.
  
  
  CONCLUSIONS
  NT discordance of more than 20% in monochorionic diamniotic twins is associated with an increased risk for subsequent development of Twin-to-Twin Transfusion Syndrome, and with earlier presentation of symptoms.
authors: Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, The Netherlands. I.Linskens@vumc.nl
authors: Ingeborg H
authors: IH
authors: Linskens
authors: Yolanda M
authors: YM
authors: de Mooij
authors: Jos W
authors: JW
authors: Twisk
authors: Willem J
authors: WJ
authors: Kist
authors: Dick
authors: D
authors: Oepkes
authors: John M
authors: JM
authors: van Vugt
mesh_terms: D000328:Adult; D005260:Female; D005330:Fetofetal Transfusion / Q000175:diagnosis / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D048208:Nuchal Translucency Measurement; D011237:Predictive Value of Tests; D011247:Pregnancy; D014427:Twins