Neurobehavioral effects of cyclohexane in rat and human.
The neurobehavioral effects of inhaled cyclohexane in rats and humans are investigated to define relationships between internal doses and acute central nervous system effects. Rats are exposed for 3 consecutive days at target concentrations of 0, 1.4, 8, and 28 g/m(3), 8 h/d. Measurements include standardized observational measures, spontaneous motor activity assessments, and learned visual discrimination performance. Cyclohexane concentrations in blood and brain are measured to assess internal exposure. Human volunteers are exposed for 4 hours to 86 or 860 mg/m(3) in 2 test sessions. Neurobehavioral effects are measured using a computerized neurobehavioral test battery. In rats, there are slight reductions in psychomotor speed in the high-exposure group but minimal central nervous system effects. In humans, there are no significant treatment-related effects at the levels tested.
Lammers
J H C M
JH
TNO Quality of Life, Zeist, The Netherlands.
Emmen
H H
HH
Muijser
H
H
Hoogendijk
E M G
EM
McKee
R H
RH
Owen
D E
DE
Kulig
B M
BM
D000328:Adult; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D003510:Cyclohexanes / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D004192:Discrimination, Psychological / Q000187:drug effects; D056344:Executive Function / Q000187:drug effects; D006304:Health Status; D006801:Humans; D008297:Male; D008954:Models, Biological; D009043:Motor Activity / Q000187:drug effects; D009483:Neuropsychological Tests; D020258:Neurotoxicity Syndromes / Q000473:pathology* / Q000523:psychology*; D010599:Pharmacokinetics; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000493:pharmacokinetics / Q000633:toxicity*; D013045:Species Specificity; D014825:Vocabulary; D055815:Young Adult
D003510:Cyclohexanes; D012997:Solvents; C506365:Cyclohexane