title: The comparative antimalarial properties of weak base and neutral synthetic ozonides.
abstract: Thirty-three N-acyl 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. For these ozonides, weak base functional groups were not required for high antimalarial potency against Plasmodium falciparum in vitro, but were necessary for high antimalarial efficacy in Plasmodium berghei-infected mice. A wide range of LogP/D(pH)(7.4) values were tolerated, although more lipophilic ozonides tended to be less metabolically stable.
authors: College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE, USA.
authors: Yuanqing
authors: Y
authors: Tang
authors: Sergio
authors: S
authors: Wittlin
authors: Susan A
authors: SA
authors: Charman
authors: Jacques
authors: J
authors: Chollet
authors: Francis C K
authors: FC
authors: Chiu
authors: Julia
authors: J
authors: Morizzi
authors: Lisa M
authors: LM
authors: Johnson
authors: Josefina Santo
authors: JS
authors: Tomas
authors: Christian
authors: C
authors: Scheurer
authors: Chistopher
authors: C
authors: Snyder
authors: Lin
authors: L
authors: Zhou
authors: Yuxiang
authors: Y
authors: Dong
authors: William N
authors: WN
authors: Charman
authors: Hugues
authors: H
authors: Matile
authors: Heinrich
authors: H
authors: Urwyler
authors: Arnulf
authors: A
authors: Dorn
authors: Jonathan L
authors: JL
authors: Vennerstrom
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D051379:Mice; D010963:Plasmodium falciparum / Q000187:drug effects; D051381:Rats
chemical_list: C503429:1,2,4-trioxane; D000962:Antimalarials; D006571:Heterocyclic Compounds