title: Furosemide infusion prevents the requirement of renal replacement therapy after cardiac surgery.
abstract: OBJECTIVE
  Acute kidney injury (AKI) is a devastating complication following cardiac surgery and the ideal management is controversial. This prospective, randomized, open-label and double-blinded study analyzed the renoprotective effects of furosemide infusion and intermittent bolus therapy administered with dopamine infusion in cardiac surgical patients.
  
  
  METHODS
  Between August 1, 2007 and July 31, 2008, 100 adult patients undergoing elective coronary artery bypass surgery (CABG) surgery with normal renal function (creatinine <1.4 mg/dl) were enrolled in the study. The patients were randomized for the comparison of intermittent (Group 1, n=50, 1mg-3mg/kg) and continuous infusion of furosemide (Group 2, n=50, 10mg/ml). Continuous variables were expressed as mean+/- SD and compared by unpaired Student's t test or ANOVA for repeated measures. Statistical significance was assumed if p value was <0.05.
  
  
  RESULTS
  Renal replacement therapy (RRT) was used in 5% of patients (all in group 1, p=0.028). The 30-day mortality was 5%. Only 2 patients became hemodialysis dependent in group 1. Group 2 patients showed a continuous and higher urine output postoperatively than group 1 (p<0.001). Both groups had significant increase in peak postoperative serum creatinine values (p<0.001), however peak postoperative creatinine-clearance was significantly lower in group 1 (p<0.001).
  
  
  CONCLUSIONS
  Acute kidney injury necessitating RRT makes a small percentage of patients undergoing cardiac surgery and if RRT is not required the survival is excellent. Continuous infusion of furosemide seems to be effective in promoting diuresis and decreasing the need for RRT. However further multicenter studies with different doses of furosemide are required to confirm these results.
authors: Department of Cardiovascular Surgery, Bahçelievler Medicana Hospital, Istanbul, Turkey. atikemd@gmail.com
authors: Atike Tekeli
authors: AT
authors: Kunt
authors: Serdar
authors: S
authors: Akgün
authors: Nazan
authors: N
authors: Atalan
authors: Nazan
authors: N
authors: Bitir
authors: Sinan
authors: S
authors: Arsan
mesh_terms: D000328:Adult; D000368:Aged; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000379:methods; D003404:Creatinine / Q000097:blood; D003920:Diabetes Mellitus / Q000453:epidemiology; D004231:Diuresis; D004232:Diuretics / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005665:Furosemide / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D007262:Infusions, Intravenous; D007668:Kidney / Q000293:injuries; D007674:Kidney Diseases / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D017582:Renal Replacement Therapy / Q000379:methods* / Q000401:mortality
chemical_list: D004232:Diuretics; D005665:Furosemide; D003404:Creatinine