title: [Bioinformatic search of plant protein kinases, participating in microtubule protein phosphorylation and cell division regulation].
abstract: Bioinformatic search of plant homologues of human protein kinases SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK2 and PASK participating in microtubular protein phosphorylation and cell division regulation is carried out. The homologues of protein kinases SLK, MAST2 and AURKA were identified. It is found that closest homologue of human AURKA protein kinase is a protein with unknown function A7PY12_VITVI (STALK--Serine-Threonine Aurora-Like Kinase) from grape (Vitis vinifera). Reconstruction and analysis of three-dimensional structure of STALK protein confirmed its relation to the group of AURKA-like protein kinases.
authors: P A
authors: PA
authors: Karpov
authors: E S
authors: ES
authors: Nadezhdina
authors: A I
authors: AI
authors: Emets
authors: V G
authors: VG
authors: Matusov
authors: A Iu
authors: AIu
authors: Nyporko
authors: N Iu
authors: NIu
authors: Shashina
authors: Ia B
authors: IaB
authors: Blium
mesh_terms: D000595:Amino Acid Sequence; D064096:Aurora Kinase A; D064127:Aurora Kinases; D020134:Catalytic Domain; D002455:Cell Division / Q000502:physiology*; D019295:Computational Biology; D030562:Databases, Protein; D006801:Humans; D008868:Microtubule Proteins / Q000737:chemistry / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism / Q000502:physiology*; D008969:Molecular Sequence Data; D010766:Phosphorylation; D010802:Phylogeny; D010940:Plant Proteins / Q000737:chemistry / Q000502:physiology*; D011494:Protein Kinases / Q000737:chemistry / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000502:physiology; D017386:Sequence Homology, Amino Acid; D027843:Vitis / Q000166:cytology / Q000378:metabolism
chemical_list: D008868:Microtubule Proteins; D010940:Plant Proteins; D011494:Protein Kinases; C576917:AURKA protein, human; D064096:Aurora Kinase A; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases