Structural determination of aspericins A-C, new furan and pyran derivates from the marine-derived fungus Rhizopus sp. 2-PDA-61, by 1D and 2D NMR spectroscopy.
Three new furan and pyran derivatives named aspericins A-C (1-3), as well as a known asperic acid (4), have been isolated from the marine-derived fungus Rhizopus sp. 2-PDA-61. The complete (1)H and (13)C NMR assignments for the new compounds were carried out using (1)H, (13)C, DEPT, COSY, HMQC, HMBC, and NOESY NMR experiments. Compounds 1-3 were evaluated for their cytotoxic activities on P388, A549, HL-60, and BEL-7420 cell lines by the MTT and SRB methods.
Wang
Fazuo
F
Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, P. R. China.
Zhu
Tianjiao
T
Zhang
Min
M
Lin
Aiqun
A
Zhu
Weiming
W
Gu
Qianqun
Q
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D003903:Deuterium; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006537:Heptanoates / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012233:Rhizopus / Q000737:chemistry*; D013237:Stereoisomerism; D018675:Toxicity Tests
D000970:Antineoplastic Agents; D005663:Furans; D006537:Heptanoates; D011714:Pyrans; C548363:aspericin A; C548364:aspericin B; C548365:aspericin C; D003903:Deuterium