Slow growing flat-type primary malignant melanoma of the esophagus treated with cap-assisted EMR.
We report a rare case of flat-type primary malignant melanoma of the esophagus treated with endoscopic mucosal resection (EMR). A 64-year-old woman was referred for examination of a small pigmented lesion located in the mid esophagus. On endoscopy, the lesion exhibited almost no change in size over the year. Cap-assisted EMR was performed en bloc. The histopathological findings showed atypical melanocyte proliferation in the basal layer, spindle cells, and epithelioid cell proliferation with nuclear enlargement and a few mitotic figures. Histopathological examination confirmed the diagnosis of primary malignant melanoma. Immunostaining for S-100 protein and HMB-45 antibody were positive, and the Ki-67 index was low. The patient was discharged without additional surgical resection and/or chemotherapy. The patient had no symptoms and no signs of recurrence 20 months after EMR. There has been no report on a slow growing esophageal melanoma. It is difficult to estimate the malignant behavior of this case.
Miyatani
Hiroyuki
H
Department of Gastroenterology, Jichi Medical University, Saitama Medical Center, Omiya, Saitama, Japan. miyatani@omiya.jichi.ac.jp
Yoshida
Yukio
Y
Ushimaru
Shinya
S
Sagihara
Noriyoshi
N
Yamada
Shigeki
S
D004724:Endoscopy; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008545:Melanoma / Q000473:pathology* / Q000601:surgery*; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology / Q000601:surgery