Recurrent ischemic stroke in a patient with idiopathic thrombocytopenic purpura.
Recurrent cerebral infarctions developed in a patient with idiopathic thrombocytopenic purpura (ITP). At the time of the first stroke, there were large thrombi in the right proximal internal carotid artery (ICA) and an occlusion of the right terminal ICA. The occlusion was recanalized by intra-arterial infusion of urokinase. After 20 months, he suffered another ischemic attack. The autoantibodies in ITP directed against antigens presented on both platelets and endothelial cells might induce the endothelial damage, thrombus formation, and embolic occlusion of the artery.
Rhee
Hak Young
HY
Department of Neurology, Kyung Hee University East-West Neo Medical Center, Kyunghee Univ #149, Sangil-dong, Gangdong-gu, Seoul, South Korea. azzo73@gmail.com
Choi
Hye-Yeon
HY
Kim
Sang-Beom
SB
Shin
Won-Chul
WC
D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage; D001323:Autoantibodies / Q000097:blood; D002545:Brain Ischemia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D002533:Cerebral Angiography; D038524:Diffusion Magnetic Resonance Imaging; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D020767:Intracranial Thrombosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D012008:Recurrence; D020521:Stroke / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D015912:Thrombolytic Therapy; D016896:Treatment Outcome; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage
D000925:Anticoagulants; D001323:Autoantibodies; D005343:Fibrinolytic Agents; D006493:Heparin; D014568:Urokinase-Type Plasminogen Activator