[Long-term results of surgical plus chemotherapy for stage I lung adenocarcinoma].
OBJECTIVE
Observe the effect of operation plus post-operative chemotherapy for long-term results of stage I lung adenocarcinoma.


METHODS
From January 1994 to January 2005, 427 patients with stage I lung adenocarcinoma underwent surgical resection therapy. The comparison of long-term survival rates was made between post-chemotherapy and surgical resection alone.


RESULTS
The analyses disclosed that the stage I a 1, 3, 5 and 10-year survival rate of post-chemotherapy was 100.00%, 92.34%, 86.17% and 74.82%, respectively, while in surgical resection alone was 96.63%, 88.11%, 79.52% and 65.85%, respectively. The stage I b 1, 3, 5 and 10-year survival rate of post-chemotherapy was 96.84%, 77.99%, 69.56% and 64.36%, respectively, while in surgical resection alone was 85.65%, 67.11%, 59.56% and 53.06%, respectively. There was statistically significant difference between 1 year survival rate of stage I a patients with post-chemotherapy and those with surgical resection alone (P < 0.05); 1 year survival rate of stage I b patients with post-chemotherapy and those with surgical resection alone (P < 0.01).


CONCLUSIONS
The operation plus post-operative chemotherapy is better than surgical resection alone in stage I a and I b. Surgical plus post-operative chemotherapy mode is indispensable for better prognosis of stage I a and I b lung adenocarcinoma.
Duan
Yong
Y
Beijing Research Institute of Tuberculosis and Thoracic Tumors, Beliing Chest Hospital, Chest Surgery Department, Beijing 101149, China.
Bai
Lian-qi
LQ
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate