title: Comparison of sirolimus and paclitaxel-eluting stents for complex coronary lesions: an intravascular ultrasound study.
abstract: OBJECTIVE
  Recent intravascular ultrasound (IVUS) studies of sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) have demonstrated a significant reduction in neointimal hyperplasia (NIH) based on simple coronary lesions. In this study, we evaluated the efficacy of SES and PES using IVUS in complex coronary lesions.
  
  
  METHODS
  Eighty-seven patients in whom 95 drug-eluting stents (66 SES and 29 PES) were implanted in complex coronary lesions were enrolled in this study. Case selection was based on the availability of IVUS and quantitative coronary angiographic (QCA) examinations at the index procedure and at follow-up. The neointimal volume index (volume/length: NIVI) and percent neointimal volume (% NIV) were calculated. The longitudinal length of stented segments without IVUS-detectable NIH was also evaluated.
  
  
  RESULTS
  The baseline patient demographics were similar between the SES and PES groups. At follow-up, no significant differences were observed in the vessel, plaque, or stent volume indices between the two groups. However, the NIVI and % NIV were significantly lower in the SES group (p<0.01). The longitudinal length of stented segments without IVUS-detectable NIH was significantly higher in the SES group (p<0.01). The net gain was significantly larger in the SES group (2.3+/-0.7 vs. 2.0x0.6 mm, p=0.025), while the rate of major adverse cardiac events was similar between the two groups.
  
  
  CONCLUSIONS
  Although SES showed significantly greater suppression of NIH at follow-up, both stents were highly effective at inhibiting NIH in complex coronary lesions.
authors: Division of Cardiology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University College of Medicine, Jung-gu, Daegu, Korea.
authors: Yun-Kyeong
authors: YK
authors: Cho
authors: Seung-Ho
authors: SH
authors: Hur
authors: Hyun-Tae
authors: HT
authors: Kim
authors: In-Cheol
authors: IC
authors: Kim
authors: Hyoung-Seob
authors: HS
authors: Park
authors: Hyuck-Jun
authors: HJ
authors: Yoon
authors: Chang-Wook
authors: CW
authors: Nam
authors: Hyungseop
authors: H
authors: Kim
authors: Seong-Wook
authors: SW
authors: Han
authors: Yoon-Nyun
authors: YN
authors: Kim
authors: Kwon-Bae
authors: KB
authors: Kim
mesh_terms: D000328:Adult; D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D054855:Drug-Eluting Stents / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage*; D020123:Sirolimus / Q000008:administration & dosage*; D017539:Tunica Intima / Q000473:pathology; D018084:Ultrasonography, Interventional / Q000379:methods*
chemical_list: D017239:Paclitaxel; D020123:Sirolimus