title: New hemostatic agents in the combat setting.
abstract: BACKGROUND
  Hemorrhage is a leading cause of potentially preventable death in both civilian and military trauma patients. Animal data have shown that hemostatic bandages reduce hemorrhage and improve survival. This article reports recent clinical observations regarding the efficacy and evolution of use of two new hemostatic bandages employed in the global war on terrorism.
  
  
  METHODS
  We performed a retrospective cohort review of soldiers treated with either the QuikClot or HemCon hemostatic bandages between April and October 2006. Hemostatic dressings were placed on wounds either in the field or at the combat support hospital (CSH).
  
  
  RESULTS
  During the 6-month study period, 1691 trauma patients were admitted to the CSH. Fifty uses of hemostatic dressings in 44 patients (2.6% of admissions) were identified. Forty patients were treated with HemCon dressings, three patients with QuikClot, and one with both QuikClot and HemCon. Eighteen percent of the dressings were used in the field, predominantly on extremity wounds (7/8). In contrast, most dressings used in the CSH were for truncal wounds (26/36 patients). Hemostatic dressings were applied to extremity wounds in prehospital and hospital settings, either alone or in conjunction with tourniquets. In surviving patients (95%), the treating surgeon determined that the hemorrhage was either stopped or greatly decreased by use of hemostatic dressings. Two of the four patients treated with QuikClot had burns from exothermic reactions, while no adverse reactions were noted with HemCon.
  
  
  CONCLUSIONS
  Hemostatic agents stop or decrease bleeding. Whereas HemCon appears to be safe, QuikClot may produce superficial burns. These new hemostatic agents have a place in the surgical armamentarium to assist in controlling internal hemorrhage from truncal and pelvic hemorrhage, especially during damage-control surgery.
authors: U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas 78234-6315, USA.
authors: E Darrin
authors: ED
authors: Cox
authors: Martin A
authors: MA
authors: Schreiber
authors: John
authors: J
authors: McManus
authors: Charles E
authors: CE
authors: Wade
authors: John B
authors: JB
authors: Holcomb
mesh_terms: D001458:Bandages; D002056:Burns; D015331:Cohort Studies; D005107:Explosions; D006470:Hemorrhage / Q000517:prevention & control* / Q000628:therapy; D006489:Hemostatic Techniques; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008889:Military Personnel; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D014857:Warfare; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D006490:Hemostatics