Multi-scale modeling of excitation-contraction coupling in the normal and failing heart.
Here we describe new computational models of cardiac electromechanics starting from the cellular scale and building to the tissue, organ and system scales. We summarize application to human genetic diseases (LQT1 and LQT3) and to modeling of congestive heart failure.
Kerckhoffs
Roy C P
RC
Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA. roy@bioeng.ucsd.edu
Campbell
Stuart G
SG
Flaim
Sarah N
SN
Howard
Elliot J
EJ
Sierra-Aguado
Jazmin
J
Mulligan
L J
LJ
McCulloch
Andrew D
AD
D000465:Algorithms; D003198:Computer Simulation; D004594:Electrophysiology / Q000379:methods; D004867:Equipment Design; D006321:Heart / Q000503:physiopathology*; D006329:Heart Conduction System; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D008133:Long QT Syndrome; D008955:Models, Cardiovascular; D008957:Models, Genetic; D032342:Muscle Cells / Q000473:pathology; D009154:Mutation; D009200:Myocardial Contraction; D012984:Software