Interleukin-6 polymorphisms modify the risk of periodontitis: a systematic review and meta-analysis.
OBJECTIVE
To clarify the association of IL-6 polymorphisms and periodontitis, a meta-analysis of case-control studies and a systemic review were conducted.


METHODS
We performed a literature search using PubMed and Medline database to May 2009, with no restrictions. We also reviewed references from all retrieved articles. Six case-control studies involving 1 093 periodontitis cases and 574 controls were selected for meta-analysis to assess the purported associations between IL-6 polymorphisms and the risk of periodontitis. IL-6 -174 G/C and -572 C/G polymorphisms were included in the present meta-analysis, and the association between IL-6 -6331 T/C polymorphism and the risk of periodontitis was adequately reviewed as well.


CONCLUSIONS
The present meta-analysis indicates that the IL-6 -174 G allele could not modify the risk of chronic periodontitis, but increased the risk of aggressive periodontitis. And -572 C/G polymorphism is associated with the pathogenesis of periodontitis, including chronic periodontitis or aggressive periodontitis.
Shao
Mei-ying
MY
State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
Huang
Ping
P
Cheng
Ran
R
Hu
Tao
T
D000483:Alleles; D016022:Case-Control Studies; D002908:Chronic Disease; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D010518:Periodontitis / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic; D012306:Risk
D015850:Interleukin-6