[Endocrine and metabolic effects of antiepileptic drugs].
The antiepileptic drugs (AED) have been widely used for a great deal of people--in the treatment of epilepsy and other diseases--throughout the world. Continuous and prolonged use of AED may be associated with adverse effects in different systems, including a variety of endocrine and metabolic abnormalities. In this review, the relationship of AED with alterations in bone mineral metabolism, energy balance and body weight, gonadal function and thyroid metabolism was revised, as well as their clinical utility in the treatment of diabetic neuropathy.
Bortolini
Luis Gustavo C
LG
Hospital das Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil.
Kulak
Carolina A M
CA
Borba
Victoria Z C
VZ
Silvado
Carlos E
CE
Boguszewski
Cesar L
CL
D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D003929:Diabetic Neuropathies / Q000188:drug therapy; D004702:Endocrine Glands / Q000187:drug effects* / Q000378:metabolism; D006801:Humans
D000927:Anticonvulsants