Kinetic and thermodynamic solubility values of some bioactive compounds.
Thermodynamic solubility is a decisive physicochemical property in drug development. The Chasing Equilibrium method offers an alternative to the classical procedures to measure the solubility of compounds with acid-base properties. The method is fast and yields accurate results. In this work, the solubility of several compounds including acids and bases was determined through the Chasing Equilibrium approach. A study of experimental conditions in terms of sample weight was performed to measure solubilities. The study shows that only a limited range of weights, depending on the nature and solubility of the compounds, is adequate to obtain reliable results.
Shoghi
Elham
E
Departament de Química Analítica and Institut de Biomedicina (IBUB), Universitat de Barcelona, Martí i Franquès 1-11, ES-08028 Barcelona.
Fuguet
Elisabet
E
Ràfols
Clara
C
Bosch
Elisabeth
E
D000143:Acids; D000465:Algorithms; D000468:Alkalies; D002851:Chromatography, High Pressure Liquid; D007700:Kinetics; D008012:Lidocaine / Q000737:chemistry; D010226:Parabens / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility; D013816:Thermodynamics
D000143:Acids; D000468:Alkalies; D010226:Parabens; D004364:Pharmaceutical Preparations; D008012:Lidocaine