title: Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats.
abstract: Collagen, a major extracellular matrix macromolecule, is widely used for biomedical purposes. We investigated the absorption mechanism of low molecular weight collagen hydrolysate (LMW-CH) and its effects on osteoporosis in rats. When administered to Wistar rats with either [(14)C]proline (Pro group) or glycyl-[(14)C]prolyl-hydroxyproline (CTp group), LMW-CH rapidly increased plasma radioactivity. LMW-CH was absorbed into the blood of Wistar rats in the peptide form. Glycyl-prolyl-hydroxyproline tripeptide remained in the plasma and accumulated in the kidney. In both groups, radioactivity was retained at a high level in the skin until 14 days after administration. Additionally, the administration of LMW-CH to ovariectomized stroke-prone spontaneously hypertensive rats increased the organic substance content and decreased the water content of the left femur. Our findings show that LMW-CH exerts a beneficial effect on osteoporosis by increasing the organic substance content of bone.
authors: Laboratory of Nutrition, Department of Science of Food Function and Health, Graduate School of Agricultural Science, Tohoku University 1-1 Tsutsumidori-Amamiyamachi, Sendai 981-8555, Japan.
authors: Mari
authors: M
authors: Watanabe-Kamiyama
authors: Muneshige
authors: M
authors: Shimizu
authors: Shin
authors: S
authors: Kamiyama
authors: Yasuki
authors: Y
authors: Taguchi
authors: Hideyuki
authors: H
authors: Sone
authors: Fumiki
authors: F
authors: Morimatsu
authors: Hitoshi
authors: H
authors: Shirakawa
authors: Yuji
authors: Y
authors: Furukawa
authors: Michio
authors: M
authors: Komai
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D002645:Chickens; D003094:Collagen / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D004195:Disease Models, Animal; D005260:Female; D005269:Femur / Q000378:metabolism; D006801:Humans; D008970:Molecular Weight; D010024:Osteoporosis / Q000188:drug therapy* / Q000378:metabolism; D010052:Ovariectomy; D011492:Protein Hydrolysates / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011492:Protein Hydrolysates; D003094:Collagen