[Bioinformatic search of plant protein kinases, participating in microtubule protein phosphorylation and cell division regulation].
Bioinformatic search of plant homologues of human protein kinases SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK2 and PASK participating in microtubular protein phosphorylation and cell division regulation is carried out. The homologues of protein kinases SLK, MAST2 and AURKA were identified. It is found that closest homologue of human AURKA protein kinase is a protein with unknown function A7PY12_VITVI (STALK--Serine-Threonine Aurora-Like Kinase) from grape (Vitis vinifera). Reconstruction and analysis of three-dimensional structure of STALK protein confirmed its relation to the group of AURKA-like protein kinases.
Karpov
P A
PA
Nadezhdina
E S
ES
Emets
A I
AI
Matusov
V G
VG
Nyporko
A Iu
AIu
Shashina
N Iu
NIu
Blium
Ia B
IaB
D000595:Amino Acid Sequence; D064096:Aurora Kinase A; D064127:Aurora Kinases; D020134:Catalytic Domain; D002455:Cell Division / Q000502:physiology*; D019295:Computational Biology; D030562:Databases, Protein; D006801:Humans; D008868:Microtubule Proteins / Q000737:chemistry / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism / Q000502:physiology*; D008969:Molecular Sequence Data; D010766:Phosphorylation; D010802:Phylogeny; D010940:Plant Proteins / Q000737:chemistry / Q000502:physiology*; D011494:Protein Kinases / Q000737:chemistry / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000502:physiology; D017386:Sequence Homology, Amino Acid; D027843:Vitis / Q000166:cytology / Q000378:metabolism
D008868:Microtubule Proteins; D010940:Plant Proteins; D011494:Protein Kinases; C576917:AURKA protein, human; D064096:Aurora Kinase A; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases