Acute subdural hemorrhage associated with rifampicin-induced thrombocytopenia.
Thrombocytopenia is a major adverse effect of several drug treatments. Rifampicin has been recognized as a cause of immune thrombocytopenia. A 68-year-old woman diagnosed with pulmonary tuberculosis was taking the standard four-drug antituberculosis regimen for 4 months. She presented with decreased responsiveness and headache. Brain MRI revealed subdural hemorrhage along the falx cerebri and high convexity. The platelet count was 8,000 microL(-1). Intracranial hemorrhage due to rifampicin-induced thrombocytopenia has not, to our knowledge, been previously reported. We report a patient with acute subdural hemorrhage associated with rifampicin-induced thrombocytopenia.
Kang
Sa-Yoon
SY
Department of Neurology, College of Medicine, Cheju National University, Jeju, South Korea. neurokang@cheju.ac.kr
Choi
Jay Chol
JC
Kang
Ji-Hoon
JH
Lee
Jung Seok
JS
D000208:Acute Disease; D000368:Aged; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D005260:Female; D006408:Hematoma, Subdural / Q000150:complications* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D012293:Rifampin / Q000009:adverse effects* / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications* / Q000473:pathology; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
D000995:Antitubercular Agents; D012293:Rifampin