title: Efficiency of fractional anisotropy and apparent diffusion coefficient on diffusion tensor imaging in prognosis of neonates with hypoxic-ischemic encephalopathy: a methodologic prospective pilot study.
abstract: OBJECTIVE
  The DTI parameters (FA and ADC) reflect the properties of the brain microstructure. Decreased anisotropy is a common feature of cerebral tissue abnormalities. Our study investigates the neurologic prognostic efficiency of these parameters in white (PLIC, CP) and gray matter (PP) in the first days of life in term neonates with HIE. We hypothesize that lesions in related brain areas could be part of a physiopathologic substratum supporting neurologic deficiencies in this population.
  
  
  METHODS
  A total of 22 neonates (13 girls and 9 boys; mean gestational age, 40 weeks +/- 9 days; birth weight, 3203 +/- 584 g) underwent brain MR imaging between day 1 and day 6 after birth; 6-noncollinear direction DTI was performed. FA and ADC were measured on specific brain areas. Amiel-Tison score was performed on day 8.5 +/- 4 (group A, favorable outcome [n = 16]; group B, unfavorable outcome [n = 6]).
  
  
  RESULTS
  Intraobserver and interobserver comparison in DTI parameter measurements showed a coefficient of variability of less than 5%. In PLIC and PP, the ADC values were lower in group B compared with group A (P = .000027), whereas in PLIC and CP, the FA values were lower in group B compared with group A (P < .02).
  
  
  CONCLUSIONS
  These findings indicate that a poor early neurologic outcome in neonates with HIE is associated with lower FA or ADC values in specific areas of white or gray matter. The difference in ADC/FA changes in the different brain areas explored may support possibly different pathologic processes.
authors: Université de Bordeaux, Bordeaux, France. olivier.brissaud@chu-bordeaux.fr
authors: O
authors: O
authors: Brissaud
authors: M
authors: M
authors: Amirault
authors: F
authors: F
authors: Villega
authors: O
authors: O
authors: Periot
authors: J F
authors: JF
authors: Chateil
authors: M
authors: M
authors: Allard
mesh_terms: D001921:Brain / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods* / Q000706:statistics & numerical data*; D004185:Disability Evaluation; D005260:Female; D005865:Gestational Age; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000473:pathology*; D007231:Infant, Newborn; D008297:Male; D015588:Observer Variation; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies