title: Synthesis and Characterization of Anionic Triazine Dendrimers with a Labile Disulfide Core.
abstract: Anionic dendrimers based on melamine with disulfide bonds at the core were prepared to investigate the solubility of these architectures, the ability of these molecules to solubilize pyrene as a model drug, and the ability of these architectures to undergo thiol-disulfide exchange. The ability to solubilize pyrene is directly correlated with molecular weight of the dendrimer-aggregation of dendrons does not occur. Thiol-disulfide exchange occurs rapidly using dithiothreitol as the reductant to yield dendrimers with thiol cores that can undergo oxidation in air to yield the original dendrimer.
authors: Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA.
authors: Wen
authors: W
authors: Zhang
authors: Sanjiv
authors: S
authors: Lalwani
authors: Abdellatif
authors: A
authors: Chouai
authors: Eric E
authors: EE
authors: Simanek