title: Cytotoxic and anti-infective sesquiterpenes present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae).
abstract: A pharmacological screening of the ethanol extract and fractions of two Peruvian medicinal plants, Plagiochila disticha and Ambrosia peruviana, led to the isolation and characterization of three ENT-2,3-secoaromadendrane-type sesquiterpenoids, named plagiochiline A ( 1), I ( 2), and R ( 3), as well as of two pseudoguaianolids, damsin ( 4) and confertin ( 5), which exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 1, 4, and 5 were also investigated for their in vitro antileishmanial, trypanocidal, and antituberculosis activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes, as well as against MDR and sensitive strains of Mycobacterium tuberculosis, respectively.
authors: Department of Chemistry, University of Louisville, Louisville, KY 40292, USA.
authors: José C
authors: JC
authors: Aponte
authors: Han
authors: H
authors: Yang
authors: Abraham J
authors: AJ
authors: Vaisberg
authors: Denis
authors: D
authors: Castillo
authors: Edith
authors: E
authors: Málaga
authors: Manuela
authors: M
authors: Verástegui
authors: Lavona K
authors: LK
authors: Casson
authors: Nicole
authors: N
authors: Stivers
authors: Paula J
authors: PJ
authors: Bates
authors: Rosario
authors: R
authors: Rojas
authors: Irma
authors: I
authors: Fernandez
authors: Walter H
authors: WH
authors: Lewis
authors: César
authors: C
authors: Sarasara
authors: Michel
authors: M
authors: Sauvain
authors: Robert H
authors: RH
authors: Gilman
authors: Gerald B
authors: GB
authors: Hammond
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D019659:Asteraceae / Q000737:chemistry*; D052176:Azulenes / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D004852:Epoxy Compounds / Q000302:isolation & purification*; D006801:Humans; D010568:Peru; D010946:Plants, Medicinal / Q000737:chemistry; D011714:Pyrans / Q000302:isolation & purification*; D012717:Sesquiterpenes / Q000302:isolation & purification*
chemical_list: D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D052176:Azulenes; D004852:Epoxy Compounds; D011714:Pyrans; D012717:Sesquiterpenes; C012266:damsin; C012259:confertin; C089886:plagiochilin A