Expression of interferon-alpha and Mx protein in the livers of pigs experimentally infected with swine hepatitis E virus.
Expression of interferon-alpha (IFN-alpha) and Mx protein in the livers of pigs experimentally infected with swine hepatitis E virus (HEV) was examined immunohistochemically. Five infected and five non-infected pigs were killed at 3, 7, 14, 21, 29 and 50 days post-inoculation (dpi). Tissues were collected from each pig at necropsy. Multifocal lymphoplasmacytic hepatitis (P=0.042) and focal hepatocellular necrosis (P=0.037) were significantly more frequent in the swine HEV-infected pigs than in the non-infected control pigs. Immunohistochemical analysis detected expression of IFN-alpha and Mx protein by macrophages/Kupffer cells, lymphocytes and hepatocytes in the livers of infected pigs.
Lee
Y H
YH
Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of South Korea.
Ha
Y
Y
Chae
C
C
D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism*; D016751:Hepatitis E / Q000378:metabolism / Q000662:veterinary* / Q000821:virology; D016752:Hepatitis E virus; D006524:Hepatitis, Viral, Animal / Q000378:metabolism / Q000821:virology; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D016898:Interferon-alpha / Q000235:genetics / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000821:virology; D064547:Myxovirus Resistance Proteins; D012333:RNA, Messenger / Q000378:metabolism; D013552:Swine; D013553:Swine Diseases / Q000378:metabolism* / Q000821:virology
D016898:Interferon-alpha; D064547:Myxovirus Resistance Proteins; D012333:RNA, Messenger; D019204:GTP-Binding Proteins