Surface segregation assessment in poly(epsilon-caprolactone)-poly(ethylene glycol) multiblock copolymer films.
The ability to predict the in vivo performance of multiblock-copolymer-based biomaterials is crucial for their applicability in the biomedical field. In this work, XPS analysis of PCL-PEG copolymers was carried out, as well as morphological and wettability evaluations by SEM and CA measurements, respectively. XPS analysis on films equilibrated in PBS demonstrated a further enrichment in the PEG component on the surface. Copolymer films obtained by casting using different solvents showed a dependence in segregation according to the solvent employed. Cell adhesion tests demonstrated the importance of copolymer segregation and rearrangement in a wet environment, with a dependence of these phenomena on the copolymer molecular weight.
Cometa
Stefania
S
Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab) UdR-INSTM, Department of Chemistry and Industrial Chemistry, University of Pisa, Via Vecchia Livornese 1291, 56010, S. Piero a Grado, Pisa, Italy.
Chiellini
Federica
F
Bartolozzi
Irene
I
Chiellini
Emo
E
De Giglio
Elvira
E
Sabbatini
Luigia
L
D000818:Animals; D048430:Cell Shape / Q000187:drug effects; D004622:Embryo, Mammalian / Q000166:cytology; D005026:Ethylene Glycols / Q000737:chemistry* / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D008422:Materials Testing / Q000379:methods*; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D056951:Photoelectron Spectroscopy; D011091:Polyesters / Q000737:chemistry* / Q000494:pharmacology; D012997:Solvents; D013499:Surface Properties / Q000187:drug effects; D013816:Thermodynamics
D005026:Ethylene Glycols; D011091:Polyesters; D012997:Solvents; C476300:poly(epsilon-caprolactone)-b-poly(ethylene glycol)