Iron-catalyzed, microwave-promoted, one-pot synthesis of 9-substituted xanthenes by a cascade benzylation-cyclization process.
An efficient iron-catalyzed, microwave-promoted cascade benzylation-cyclization of phenols is reported. Benzyl acetates, benzyl bromides, and benzyl carbonates are suitable benzylating reagents. The reactions proceed to afford both 9-aryl and 9-alkyl xanthene derivatives in good to high yields using FeCl(3) as the catalyst under MW irradiation conditions.
Xu
Xiaobing
X
Institute of Medicinal Chemistry, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, PR China.
Xu
Xiaolei
X
Li
Hongfeng
H
Xie
Xin
X
Li
Yanzhong
Y
D002384:Catalysis; D002712:Chlorides; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D005290:Ferric Compounds / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D014966:Xanthenes / Q000138:chemical synthesis* / Q000737:chemistry
D002712:Chlorides; D005290:Ferric Compounds; D014966:Xanthenes; C024555:ferric chloride