Modeling electrical activities of a growing breast cancerous cell based on a semiconductor approach.
A two dimensional diffusion-drift model is developed to simulate the electrical activities of a breast cancerous cell during the hyperpolarization which occurs at the G1/S transition. The model focuses on calculating the temporal and the spatial patterns of the electric current densities and biopotentials generated at the cell boundary and its surroundings. Different durations for the hyperpolarization phase were studied. The results show that the electric signals generated in the tumor cell's surroundings increase as the duration of the hyperpolarization phase decreases or when the transition becomes faster.
Hassan
Ahmed
A
Electrical Engineering Department, University of Arkansas, Fayetteville, 72701, USA. amhassan@uark.edu
El-Shenawee
Magda
M
D000465:Algorithms; D001693:Biological Transport, Active; D001943:Breast Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor; D003198:Computer Simulation; D004058:Diffusion; D004563:Electrochemistry / Q000379:methods; D004574:Electromagnetic Fields; D004594:Electrophysiology / Q000379:methods*; D005260:Female; D006801:Humans; D007477:Ions; D015233:Models, Statistical; D008962:Models, Theoretical; D012666:Semiconductors
D007477:Ions