title: Maternal flaxseed diet during lactation alters milk composition and programs the offspring body composition, lipid profile and sexual function.
abstract: We evaluated the effects of maternal dietary flaxseed during lactation on milk composition, body composition and sexual function of the adult female offspring. The dams were fed a control casein diet (C) or flaxseed diet (F, 25%) throughout lactation. F mothers showed higher serum 17beta-estradiol (E2) and leptin at weaning. F mother's milk had lower total cholesterol (TC) and higher E2 and leptin. The offspring of F dams showed lower body mass (BM), body fat mass (BFM), visceral fat mass (VFM), TC and triglycerides (TG) and higher serum leptin and E2 at 21 days. F offspring showed delayed puberty onset. At 150 days, these offspring presented higher BFM, VFM, TC, TG, E2 and lower relative uterine weight and lower progesterone. In conclusion, flaxseed during lactation did affect the lipid profile, adipose tissue and sexual function in adulthood, probably due hyperestrogenism and hyperleptinemia at weaning.
authors: Department of Physiological Sciences, State University of Rio de Janeiro, Brazil.
authors: A A
authors: AA
authors: Troina
authors: M S
authors: MS
authors: Figueiredo
authors: E G
authors: EG
authors: Moura
authors: G T
authors: GT
authors: Boaventura
authors: L L
authors: LL
authors: Soares
authors: L F M F
authors: LF
authors: Cardozo
authors: E
authors: E
authors: Oliveira
authors: P C
authors: PC
authors: Lisboa
authors: M A R F
authors: MA
authors: Passos
authors: M C F
authors: MC
authors: Passos
mesh_terms: D050154:Adiposity / Q000187:drug effects; D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D019587:Dietary Supplements / Q000009:adverse effects*; D030762:Estrous Cycle / Q000187:drug effects* / Q000502:physiology; D005260:Female; D019597:Flax / Q000009:adverse effects*; D007774:Lactation / Q000187:drug effects* / Q000502:physiology; D008055:Lipids / Q000097:blood*; D008892:Milk / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012741:Sexual Maturation / Q000187:drug effects* / Q000502:physiology
chemical_list: D008055:Lipids