The role of Sirt1: at the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology.
Sirt1, a mammalian member of the sirtuin gene family, holds great potential for promoting longevity, preventing against disease and increasing cell survival. For example, studies suggest that the beneficial impact of caloric restriction in promoting longevity and cellular function may be mediated, in part, by Sirt1 through mechanisms involving PGC-1alpha, which plays important role in the regulation of cellular metabolism and inflammatory and antioxidant responses. Sirt1 may also interfere with mechanisms implicated in pathological disorders. We will present recent evidence indicating that Sirt1 may protect against Alzheimer's disease by interfering with the generation of beta-amyloid peptides. We will discuss Sirt1 as a potential novel target, in addition to the development of Sirt1 activators for the prevention and treatment of Alzheimer's disease.
Wang
Jun
J
Center of Excellence for Novel Approaches to Neurodiagnostics and Neurotherapeutics, Brain Institute, Center of Excellence for Research in Complementary and Alternative Medicine in Alzheimer's Disease, Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Fivecoat
Hayley
H
Ho
Lap
L
Pan
Yong
Y
Ling
Emi
E
Pasinetti
Giulio Maria
GM
D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000686:Amyloidosis / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D000818:Animals; D031204:Caloric Restriction; D006801:Humans; D008136:Longevity / Q000502:physiology*; D009243:NAD / Q000378:metabolism; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000378:metabolism*; D013267:Stilbenes / Q000494:pharmacology
D016564:Amyloid beta-Protein Precursor; D013267:Stilbenes; D009243:NAD; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D000077185:Resveratrol