title: An outbreak of early-onset endophthalmitis caused by Fusarium species following cataract surgery.
abstract: OBJECTIVE
  This study aimed to report an outbreak of early-onset endophthalmitis caused by Fusarium species following cataract surgery.
  
  
  METHODS
  The study was designed retrospectively to review microbiologic and medical records of eight cases of endophthalmitis caused by Fusarium species after cataract surgery performed in the same operating room and on the same date by different surgeons at Beyoğlu Eye Training and Research Hospital in Istanbul, Turkey. Seven patients had phacoemulsification and intraocular lens implantation surgery. Intracapsular cataract extraction was performed in one patient. The common feature of these surgeries was the use of intracameral injections of cefuroxime (1 mg in 0.1-ml balanced salt solution-BSS) solutions, which were preoperatively prepared from the same BSS bottle.
  
  
  RESULTS
  The duration between cataract surgery and the diagnosis of endophthalmitis was four days. Aqueous and vitreous specimens obtained from the patients grew fungus colonies that were identified according to their morphologic features and considered to be Fusarium solani. All patients underwent multiple vitrectomies with silicone oil injections. Patients were given local and systemic antifungal agents (amphotericin B and voriconazole). One patient with corneal involvement underwent evisceration despite a variety of treatments. One patient with unregulated diabetes was prephthisic without recurrence of infection. The final visual acuity of patients was between light perception and 20/100.
  
  
  CONCLUSIONS
  Fusarium should be considered in the differential diagnosis of early-onset endophthalmitis after cataract surgery. An aggressive treatment with local and systemic antifungal agents and multiple vitrectomies with silicone oil injection is helpful in the management of postoperative early-onset Fusarium endophthalmitis. In the prevention of such outbreaks, it is important to use solutions prepared differently for each patient.
authors: Beyoglu Eye Training and Research Hospital, Istanbul, Turkey.
authors: Mehmet
authors: M
authors: Cakir
authors: Serhat
authors: S
authors: Imamoğlu
authors: Osman
authors: O
authors: Cekiç
authors: Ercüment
authors: E
authors: Bozkurt
authors: Neşe
authors: N
authors: Alagöz
authors: Lütfiye
authors: L
authors: Oksüz
authors: Omer F
authors: OF
authors: Yilmaz
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004196:Disease Outbreaks; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000453:epidemiology* / Q000382:microbiology / Q000628:therapy; D017234:Eye Evisceration; D015821:Eye Infections, Fungal / Q000453:epidemiology* / Q000382:microbiology / Q000628:therapy; D005260:Female; D005670:Fusarium / Q000302:isolation & purification*; D006801:Humans; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000453:epidemiology* / Q000382:microbiology / Q000628:therapy; D018918:Phacoemulsification; D011183:Postoperative Complications; D011743:Pyrimidines / Q000627:therapeutic use; D012189:Retrospective Studies; D014230:Triazoles / Q000627:therapeutic use; D014421:Turkey / Q000453:epidemiology; D014792:Visual Acuity; D014821:Vitrectomy; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D065819:Voriconazole