Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes.
We investigated the hypoglycemic and hypolipidemic effects of two hesperertin glycosides, namely, hesperidin and cyclodextrin (CD)-clathrated hesperetin, in Goto-Kakizaki (GK) weanling rats with type 2 diabetes. We demonstrated that hesperidin and CD-hesperetin normalized glucose metabolism by altering the activities of glucose-regulating enzymes and reducing the levels of lipids in the serum and liver of the GK rats. These effects of hesperidin glycosides were partly produced by altering the expression of genes encoding the peroxisome proliferator-activated receptors, 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, and the low-density lipoprotein receptor.
Akiyama
Satoko
S
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Japan.
Katsumata
Shin-ichi
S
Suzuki
Kazuharu
K
Nakaya
Yumi
Y
Ishimi
Yoshiko
Y
Uehara
Mariko
M
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003505:Cyclodextrins / Q000494:pharmacology* / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D005786:Gene Expression Regulation / Q000187:drug effects; D006569:Hesperidin / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051381:Rats
D001786:Blood Glucose; D003505:Cyclodextrins; D000960:Hypolipidemic Agents; D006569:Hesperidin