[A case of 5-fluorouracil-induced hyperammmonia after chemotherapy for metastatic colon cancer].
A 79-year-old woman with colon cancer and multiple liver metastases was admitted to our hospital for systemic chemotherapy. She underwent first cycle of modified FOLFOX6 chemotherapy. She was confused on treatment day 5. Blood test revealed her serum ammonia level to be 121 microg/dl. We diagnosed 5-fluorouracil (5FU)-induced hyperammonemia. Conservative treatment resulted in improvement of metal status. The reason for hyperammonemia after administration of 5FU was the excess production of ammonium from metabolites of 5FU.
Nakamura
Masamoto
M
Department of Internal Medicine, Okinawa Red Cross Hospital, Japan. mnakamura2@jin-aikai.or.jp
Kobashikawa
Kasen
K
Tamura
Jiro
J
Takaki
Ryo
R
Ohshiro
Masaru
M
Matayoshi
Ryoji
R
Hirata
Tetsuo
T
Kinjyo
Fukunori
F
Fujita
Jiro
J
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D003110:Colonic Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D022124:Hyperammonemia / Q000139:chemically induced*; D002955:Leucovorin / Q000009:adverse effects; D008113:Liver Neoplasms / Q000556:secondary; D009944:Organoplatinum Compounds / Q000009:adverse effects
D000964:Antimetabolites, Antineoplastic; D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil