Plant mitochondrial RNA editing: the Strasbourg chapter.
For 8 years, it was not understood why certain genes of plant mitochondria contain CGG (arginine) codons at positions where tryptophan codons (UGG) are present in the corresponding genes of nonplant species. Identification and sequencing of a tRNA(Trp) gene showed that it is not able to decode the CGG codon. Analysis of different discrepancies in the sequences of plant mitochondrial proteins prompted us to determine directly the corresponding RNA sequences. These experiments showed that plant mitochondrial transcripts are subject to RNA editing that changes C into U, resulting in a better phylogenetic conservation of protein sequences [Gualberto et al. (1989) Nature 341, 660-662].
Grienenberger
Jean Michel
JM
Institut de Biologie Moléculaire des Plantes du CNRS, Université de Strasbourg, 12 Rue du Général Zimmer, Strasbourg, France. jeanm.grienenberger@free.fr
D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism; D001671:Biochemistry / Q000266:history / Q000379:methods; D003062:Codon; D018076:DNA, Complementary / Q000378:metabolism; D019143:Evolution, Molecular; D005602:France; D018745:Genome, Plant; D049673:History, 20th Century; D010944:Plants / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D017393:RNA Editing; D000077278:RNA, Mitochondrial; D018749:RNA, Plant / Q000378:metabolism*; D012343:RNA, Transfer / Q000378:metabolism
D003062:Codon; D018076:DNA, Complementary; D000077278:RNA, Mitochondrial; D018749:RNA, Plant; D012313:RNA; D012343:RNA, Transfer; D000604:Amino Acyl-tRNA Synthetases