Hypophysectomy for a dog with coexisting Cushing's disease and diabetes mellitus.
An 11-year-old male mixed breed dog diagnosed with Cushing's disease and diabetes mellitus was treated by hypophysectomy. After surgery, the hypercortisolemia disappeared and the diabetes status improved. The insulin requirement to control hyperglycemia gradually decreased. At 12 weeks after surgery, there was no requirement for insulin and we suspected the diabetes was completely resolved. In the present case, diabetes mellitus seems to be secondary to Cushing's disease. In conclusion, this mixed breed dog with coexisting Cushing's disease and diabetes mellitus is the first case showing the effectiveness of hypophysectomy to treat diabetes mellitus secondary to Cushing's disease in dogs.
Ishino
Hirokazu
H
Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan. hiro-ish@pp.iij4u.or.jp
Hara
Yasushi
Y
Teshima
Takahiro
T
Tanaka
Shigeki
S
Takekoshi
Susumu
S
Nezu
Yoshinori
Y
Harada
Yasuji
Y
Yogo
Takuya
T
Sako
Toshinori
T
Koyama
Hidekazu
H
Teramoto
Akira
A
Osamura
Robert Y
RY
Tagawa
Masahiro
M
D015096:3-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors; D000324:Adrenocorticotropic Hormone / Q000276:immunology; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D048909:Diabetes Complications / Q000601:surgery / Q000662:veterinary*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000662:veterinary*; D013196:Dihydrotestosterone / Q000031:analogs & derivatives / Q000627:therapeutic use; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007016:Hypophysectomy / Q000379:methods / Q000662:veterinary*; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D047748:Pituitary ACTH Hypersecretion / Q000150:complications / Q000601:surgery / Q000662:veterinary*; D010902:Pituitary Gland / Q000473:pathology
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D013196:Dihydrotestosterone; D000324:Adrenocorticotropic Hormone; D015096:3-Hydroxysteroid Dehydrogenases; C009954:trilostane