title: Cerebrospinal fluid progranulin levels in patients with different multiple sclerosis subtypes.
abstract: Progranulin has recently attracted attention due to the discovery of mutations in its encoding gene (GRN) in several cases of frontotemporal lobar degeneration, but also for a possible role in inflammatory processes. In adult central nervous system, GRN mRNA is expressed in forebrain, olfactory bulbs and spinal cord. Progranulin cerebrospinal fluid (CSF) levels were evaluated in 55 patients with multiple sclerosis (MS) as well as in 35 subjects with non-inflammatory neurological diseases (NIND), 7 individuals with other inflammatory neurological disease (OIND) and 8 controls (CON), matched for ethnic background, gender and age. No statistically significant differences were found in patients compared with either NIND, OIND or CON (P>0.05), even stratifying according to disease subtype or gender. A positive correlation between progranulin CSF levels and age was observed in patients (rho=0.29, P=0.03). According to these data, progranulin does not likely play a major role in the pathogenesis of MS.
authors: Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, via F. Sforza, 35, 20122 Milan, Italy.
authors: Milena
authors: M
authors: De Riz
authors: Daniela
authors: D
authors: Galimberti
authors: Chiara
authors: C
authors: Fenoglio
authors: Laura M
authors: LM
authors: Piccio
authors: Diego
authors: D
authors: Scalabrini
authors: Eliana
authors: E
authors: Venturelli
authors: Anna
authors: A
authors: Pietroboni
authors: Mirko
authors: M
authors: Piola
authors: Robert T
authors: RT
authors: Naismith
authors: Becky J
authors: BJ
authors: Parks
authors: Giorgio
authors: G
authors: Fumagalli
authors: Nereo
authors: N
authors: Bresolin
authors: Anne H
authors: AH
authors: Cross
authors: Elio
authors: E
authors: Scarpini
mesh_terms: D000328:Adult; D000367:Age Factors; D001927:Brain Diseases / Q000134:cerebrospinal fluid; D005006:Ethnicity; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000134:cerebrospinal fluid*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000134:cerebrospinal fluid*; D000077153:Progranulins; D012737:Sex Factors
chemical_list: C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins