[The relationship between monocyte chemoattractant protein-1 gene polymorphisms and the susceptibility to pulmonary tuberculosis].
OBJECTIVE
To explore the possible relationship between the -2518 A/G single nucleotide polymorphisms in monocyte chemoattractant protein-1 (MCP-1) gene of Chinese Han population and the susceptibility to pulmonary tuberculosis.


METHODS
A 1:1 matched case-control study was conducted from March 2008 to August 2008. The - 2518 MCP-1 A/G polymorphisms were detected in 167 pairs of subjects by reaction-restriction fragment length polymorphism (PCR-RLFP) technique. General characteristics, current disease history, past medical history and related environmental factors of tuberculosis were collected using a questionnaire designed by ourselves. Univariate analyses and multivariate conditional logistic analyses were conducted.


RESULTS
The genotype frequencies of AA, GA and GG in the case group and the control group were 21/167 (12.6%), 62/167 (37.1%), 84/167 (50.3%) and 42/167 (25.2%), 83/167 (49.7%), 42/167 (25.1%), respectively. There was a significant difference in genotype frequencies between the case and the control groups in the univariate analysis (chi2 = 24.041, P<0.01). The significant association remained after adjusting environmental factors between genotype GG (OR 1.989, 95% CI 1.154 - 3.428, chi2 = 6.124, P<0.05) and the susceptibility to pulmonary tuberculosis.


CONCLUSIONS
The -2518 MCP-1 GG genotype might be associated with susceptibility to pulmonary tuberculosis in Chinese Han population.
Yang
Ben-fu
BF
Department of Epidemiology, School of Public Health, Jining Medical College, Jining 272013, China.
Zhuang
Bin
B
Li
Fang
F
Zhang
Chun-zhi
CZ
Song
Ai-qin
AQ
D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D018932:Chemokine CCL2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014397:Tuberculosis, Pulmonary / Q000235:genetics*; D055815:Young Adult
C111835:CCL2 protein, human; D018932:Chemokine CCL2