Diffusion imaging for therapy response assessment of brain tumor.
Advanced imaging provides insight into biophysical, physiologic, metabolic, or functional properties of tissues. Because water mobility is sensitive to cellular homeostasis, cellular density, and microstructural organization, it is considered a valuable tool in the advanced imaging arsenal. This article summarizes diffusion imaging concepts and highlights clinical applications of diffusion MR imaging for oncologic imaging. Diffusion tensor imaging and its derivative maps of diffusion anisotropy allow assessment of tumor compression or destruction of adjacent normal tissue anisotropy and may aid to assess tumor infiltration and aid presurgical planning.
Chenevert
Thomas L
TL
Department of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA. tlchenev@umich.edu
Ross
Brian D
BD
D001932:Brain Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D038524:Diffusion Magnetic Resonance Imaging / Q000639:trends*; D006801:Humans; D017063:Outcome Assessment, Health Care / Q000379:methods*; D011379:Prognosis; D016896:Treatment Outcome