Last-observation-carried-forward imputation method in clinical efficacy trials: review of 352 antidepressant studies.
OBJECTIVE
To determine the prevalence, over 40 years, of using the last-observation-carried-forward (LOCF) imputation method in clinical trials, the association between use of LOCF and how the trials were conducted, and the extent of information about attrition and LOCF use in published reports.


METHODS
Retrospective analysis of the reports of randomized antidepressant efficacy trials published over a 40-year period (1965-2004).


METHODS
MEDLINE database, Cochrane reviews, reference- and bibliography-based manual search, and publication list services.


RESULTS
A total of 352 trials met the following criteria for analysis: antidepressant comparative efficacy trial, randomized design, patients with major depressive disorder, English-language article, published during 1965-2004, and first report of a trial. Design, attrition, and data analysis characteristics were recorded by investigators and trained assistants. Analyses included descriptive statistics of the trial size, duration, and number of patients who dropped out in LOCF versus non-LOCF studies, as well as the extent to which dropouts and the potential bias associated with attrition was discussed in the published report. The frequency of published antidepressant clinical trials increased from less than 1 trial/year (1965-1974) to 19 trials/year (1990-1994). Trials using the LOCF method were significantly larger than non-LOCF trials (p<0.01), and the proportion of subjects dropping out was significantly greater (p<0.05) in LOCF versus non-LOCF trials. The proportion of subjects dropping out remained relatively constant over time (approximately 30%) but was significantly greater among LOCF (30.9%) than non-LOCF (28.8%) trials (p<0.01). The LOCF study articles were more likely to report dropouts, but only 7% of these articles reported outcomes recorded for subjects before they dropped out. Less than 16% of articles discussed bias associated with dropouts, 6.8% discussed the direction of bias, and only about 2% suggested the magnitude of the bias.


CONCLUSIONS
The percentage of clinical antidepressant trials using the LOCF method and the percentage of study subjects' data imputed by using LOCF increased many-fold during 1965-2004. Published reports of trials provided little information to allow readers to assess possible bias introduced by use of the LOCF method.
Woolley
Stephen B
SB
Burlingame Center for Psychiatric Research and Education, The Institute of Living, Hartford Hospital, Hartford, Connecticut 06106, USA.
Cardoni
Alex A
AA
Goethe
John W
JW
D000928:Antidepressive Agents / Q000627:therapeutic use*; D015982:Bias; D003627:Data Interpretation, Statistical; D003865:Major Depressive Disorder / Q000188:drug therapy*; D006801:Humans; D010352:Patient Dropouts; D016032:Randomized Controlled Trials as Topic / Q000379:methods* / Q000639:trends; D012107:Research Design; D012189:Retrospective Studies
D000928:Antidepressive Agents