title: Vaccination against the influenza virus and mortality due to cardiovascular diseases in the city of Sao Paulo.
abstract: BACKGROUND
  The effect of vaccination against the influenza virus on the mortality due to cardiovascular diseases (CVD) remains controversial.
  
  
  OBJECTIVE
  To analyze the mortality by CVD before and after the start of the vaccination against the Influenza virus in the city of Sao Paulo, Brazil.
  
  
  METHODS
  We analyzed the mortality due to ischemic heart diseases (IHD), cerebrovascular diseases (CbVD) and external causes (EC) in the population of the metropolitan region of the city of Sao Paulo, Brazil, aged > or = 60 years, before and after the start of the vaccination program against Influenza. The population estimates and mortality data were obtained, respectively, from the Brazilian Institute of Geography and Statistics (IBGE; www.ibge.gov.br) and from the Brazilian Ministry of Health (www.datasus.gov.br) for the period between 1980 and 2006. The risk of death was adjusted by the direct method, using the 1960 world standard population.
  
  
  RESULTS
  The comparisons between the inclinations of the regression lines were similar for CbVD (p = 0.931) and EC (p = 0.941); however, for IHD (p = 0.022), a significant decrease was observed in the regression line of the post-vaccination period, when compared to the pre-vaccination period. A change in the tendency towards mortality after 1996 was significant only for the IHD (p = 0.022), remaining unaltered for the CbVD (p = 0.931) and EC (p = 0.941).
  
  
  CONCLUSIONS
  The vaccination against the Influenza virus was associated with a significant decrease in the mortality due to IHD.
authors: Instituto do Coração, HC, FM, USP, São Paulo, SP, Brasil. pmansur@cardiol.br
authors: Antonio de Padua
authors: Ade P
authors: Mansur
authors: Desidério
authors: D
authors: Favarato
authors: José Antonio F
authors: JA
authors: Ramires
mesh_terms: D001938:Brazil / Q000453:epidemiology; D002423:Cause of Death / Q000639:trends; D002561:Cerebrovascular Disorders / Q000401:mortality; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000517:prevention & control*; D016014:Linear Models; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000401:mortality*; D013997:Time Factors
chemical_list: D007252:Influenza Vaccines