Tetranortriterpenoids from Chisocheton paniculatus.
Seven new tetranortriterpenoids (1-7), named chisonimbolinins A-G, were isolated from twigs of Chisocheton paniculatus. Their structures were elucidated on the basis of extensive spectroscopic analyses, and the structure of 1 was confirmed by a single-crystal X-ray diffraction study. Cytotoxic activity of compounds 1-7 was evaluated using HeLa and SMMC-7721 tumor cell lines.
Yang
Ming-Hua
MH
Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Wang
Jun-Song
JS
Luo
Jian-Guang
JG
Wang
Xiao-Bing
XB
Kong
Ling-Yi
LY
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029582:Meliaceae / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D036701:Limonins