Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW).
The 3.1-Mb genome of an outbreak methicillin-resistant Staphylococcus aureus (MRSA) strain (TW20) contains evidence of recently acquired DNA, including two large regions (635 kb and 127 kb). The strain is resistant to a wide range of antibiotics, antiseptics, and heavy metals due to resistance genes encoded on mobile genetic elements and also mutations in housekeeping genes.
Holden
Matthew T G
MT
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom. mh3@sanger.ac.uk
Lindsay
Jodi A
JA
Corton
Craig
C
Quail
Michael A
MA
Cockfield
Joshua D
JD
Pathak
Smriti
S
Batra
Rahul
R
Parkhill
Julian
J
Bentley
Stephen D
SD
Edgeworth
Jonathan D
JD
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D016680:Genome, Bacterial / Q000235:genetics*; D019216:Metals, Heavy / Q000633:toxicity; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000235:genetics*; D008957:Models, Genetic; D008969:Molecular Sequence Data
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D019216:Metals, Heavy