title: Acetylcholinesterase activity, lipid peroxidation, and bioaccumulation in silver catfish (Rhamdia quelen) exposed to cadmium.
abstract: Cadmium is a metal with no biological function in superior organisms and it is very toxic even at very low concentrations. Thus the objective of this study was to verify some toxicological parameters in silver catfish (Rhamdia quelen) exposed to cadmium. In this study, silver catfish was exposed to 0 (control), 0.236, and 0.414 mg L(-1) cadmium for 7 and 14 days, followed by the same periods of recovery. The effects of cadmium on acetylcholinesterase (AChE) activity and metal accumulation in brain and muscle were verified. Thiobarbituric acid-reactive substance (TBARS) formation was evaluated in brain. An increase in TBARS levels was verified after exposure and recovery periods and AChE activity in brain was reduced after 14 days of exposure. These parameters did not return to control values after the recovery period. In muscle AChE was altered during both exposure periods. Alterations in AChE activity may be a good indicator of cadmium contamination in R. quelen.
authors: Adaptive Biochemistry Laboratory, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors: Alexandra
authors: A
authors: Pretto
authors: Vania Lucia
authors: VL
authors: Loro
authors: Vera Maria
authors: VM
authors: Morsch
authors: Bibiana Silveira
authors: BS
authors: Moraes
authors: Charlene
authors: C
authors: Menezes
authors: Bárbara
authors: B
authors: Clasen
authors: Lucélia
authors: L
authors: Hoehne
authors: Valderi
authors: V
authors: Dressler
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D002104:Cadmium / Q000493:pharmacokinetics / Q000633:toxicity*; D002397:Catfishes / Q000254:growth & development / Q000378:metabolism; D007928:Lethal Dose 50; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D018482:Muscle, Skeletal / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D017392:Thiobarbituric Acid Reactive Substances; D014874:Water Pollutants, Chemical; D002104:Cadmium; D000110:Acetylcholinesterase