ESR and electrochemical study of 1,2-disubstituted 5-nitroindazolin-3-ones and 2-substituted 3-alkoxy-5-nitro-2H-indazoles: reactivity and free radical production capacity in the presence of biological systems.
Two families of 5-nitroindazole derivatives were electrochemically studied in an aprotic solvent using cyclic voltammetry (CV) technique. The produced nitro-anion radical species were characterized using electron spin resonance spectroscopy (ESR). Also, we examined the interaction between the radical species generated from nitroindazole derivatives and glutathione (GSH). Moreover, the capacity of intraparasite and intramammals-free radical production, through ESR spectroscopy, was performed.
Folch-Cano
Christian
C
Departamento de Química Inorgánica y Analítica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.
Olea-Azar
Claudio
C
Arán
Vicente J
VJ
Diaz-Urrutia
Christian
C
D000818:Animals; D000838:Anions / Q000737:chemistry; D004563:Electrochemistry / Q000379:methods*; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D005609:Free Radicals / Q000737:chemistry; D005978:Glutathione / Q000737:chemistry; D006801:Humans; D007191:Indazoles / Q000737:chemistry* / Q000494:pharmacology; D008861:Microsomes / Q000187:drug effects; D015394:Molecular Structure; D010084:Oxidation-Reduction; D026361:Reactive Nitrogen Species / Q000737:chemistry; D014349:Trypanosoma cruzi / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
D000838:Anions; D005609:Free Radicals; D007191:Indazoles; D026361:Reactive Nitrogen Species; C530840:5-nitroindazole; D005978:Glutathione