[Progress of chronic ocular hypertensive glaucoma in rodents].
Glaucoma is characterized by progressive loss of retinal ganglion cell (RGCs), optic nerve atrophy, cupping of the optic disc, and specific visual field deficits. Elevated intraocular pressure (IOP) is considered to be a major risk factor associated with the development of this neuropathy, therefore, elevated IOP has been induced in animals to simulate key aspects of human glaucoma, in order to unlock the mechanism of this disease and seek out new therapeutic strategies. In the following review: (1) models used for the study of hypertensive glaucomatous neuropathy in rodents, (2) assessment of these animal models and (3) their usage will be described.
Liu
Li-Fang
LF
STU/CUHK Joint Shantou International Eye Center, Shantou 515041, China.
Zhang
Ming-Zhi
MZ
D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D005901:Glaucoma; D007429:Intraocular Pressure; D051379:Mice; D009798:Ocular Hypertension; D051381:Rats; D012165:Retinal Ganglion Cells