title: Neural correlates of inhibitory deficits in depression.
abstract: The present study used functional magnetic resonance imaging to examine neural correlates of inhibitory dysfunction in individuals diagnosed with major depressive disorder (MDD). Twelve MDD participants and 12 never-depressed controls completed the negative affective priming (NAP) task in the scanner. Results indicated that, in depressed participants, increased activation in the rostral anterior cingulate cortex (rACC) is associated with inhibition of negative, but not positive, words; in contrast, in nondepressed participants, inhibition of positive, but not negative, words is associated with increased activation in the rACC. These findings indicate that abnormalities in neural function, especially in the rACC, may underlie difficulties experienced by depressed individuals in inhibiting negative thoughts. These results underscore the importance of continuing to examine the relation between cognitive and neural functioning in depression in order to gain a broader and more integrative understanding of this disorder.
authors: Department of Psychology, Concordia University, Montréal, Québec, Canada.
authors: Fanny
authors: F
authors: Eugène
authors: Jutta
authors: J
authors: Joormann
authors: Rebecca E
authors: RE
authors: Cooney
authors: Lauren Y
authors: LY
authors: Atlas
authors: Ian H
authors: IH
authors: Gotlib
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000503:physiopathology*; D003866:Depressive Disorder / Q000503:physiopathology*; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D007175:Impulsive Behavior / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D011930:Reaction Time