Nephrogenic systemic fibrosis: report of an additional case with granulomatous inflammation.
Nephrogenic systemic fibrosis (NSF) is a novel disease entity described over the past 10 years. NSF is a progressive systemic fibrosing disorder that occurs arguably exclusively in patients with impaired renal function who have been exposed to gadolinium-containing contrast agents. As no single clinical or histopathologic finding is diagnostic of NSF, a careful review of the cumulative characteristics of each case is essential in making a correct diagnosis. The spectrum of histologic variants of NSF continues to expand, including a report of NSF mimicking erythema nodosum and several case reports of NSF with giant cells and calcification. We report an additional case of NSF with the uncommon pathologic features of granulomatous and lymphocytic inflammation in the fibrous septae similar to erythema nodosum.
Wilford
Casey
C
Division of Dermatology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. casey.wilford@vanderbilt.edu
Fine
Jo-David
JD
Boyd
Alan S
AS
Sanyal
Soma
S
Abraham
Jerrold L
JL
Kantrow
Sara M
SM
D000328:Adult; D003287:Contrast Media / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004893:Erythema Nodosum / Q000175:diagnosis; D005682:Gadolinium / Q000009:adverse effects*; D006099:Granuloma / Q000139:chemically induced / Q000473:pathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000009:adverse effects; D008297:Male; D054989:Nephrogenic Fibrosing Dermopathy / Q000139:chemically induced / Q000473:pathology*; D012867:Skin / Q000187:drug effects / Q000473:pathology
D003287:Contrast Media; D005682:Gadolinium