title: Prolonged cold ischemia: risk factor for acute rejection in renal grafting of cadaveric kidney transplantation.
abstract: BACKGROUND
  Exposure of renal grafting to prolonged cold ischemia time (CIT) and the association with acute rejection (AR) are known. However, there is no evidence in Mexico about this topic. Thus, the objective of this study was to evaluate prolonged CIT as a risk factor for AR in renal grafting of cadaveric kidney transplantation in a Mexican population.
  
  
  METHODS
  A cross-sectional study was carried out. Clinical files of patients undergoing renal grafting using cadaveric kidneys were reviewed from July 1994-June 2004. Prolonged CIT (=12 h) as a risk factor for AR was evaluated. Other related variables were also examined.
  
  
  RESULTS
  From 425 kidney transplantations, only 33 cases were cadaveric. Ten patients had AR. Prolonged CIT (OR 8.4; CI 1.5-44.2, p = 0.02) and azathioprine (AZA)-prednisone (PDN)-cyclosporine (CSA) combination (OR 9.1; CI 1.5-49.4, p = 0.02) were risk factors for AR. Anti-CD25 use (OR 0.6; CI 0.009-0.37, p = 0.001) and mycofenolate mofetil (MMF)-PDN-CSA combination (OR 0.1; CI 0.02-0.65, p = 0.02) were protective factors for AR.
  
  
  CONCLUSIONS
  In a Mexican population, prolonged CIT and AZA-PDN-CSA combination were risk factors for AR. Meanwhile, anti- CD25 use and MMF-PDN-CSA combination were protective factors for AR in cadaveric kidney transplantations.
authors: Hospital Regional Universitario, Secretaria de Salud, Colima, México.
authors: Oscar Manuel
authors: OM
authors: Ruiz-George
authors: Benjamín
authors: B
authors: Trujillo-Hernández
authors: Rebeca Olivia
authors: RO
authors: Millán-Guerrero
authors: Clemente
authors: C
authors: Vásquez-Jiménez
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002102:Cadaver; D050377:Cold Ischemia / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D051799:Delayed Graft Function; D004359:Drug Therapy, Combination; D006084:Graft Rejection / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D007668:Kidney / Q000098:blood supply*; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D019520:Living Donors / Q000706:statistics & numerical data; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D014019:Tissue Donors / Q000706:statistics & numerical data; D020858:Tissue and Organ Harvesting / Q000379:methods*; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents