Multiscale finite element modeling of the lamina cribrosa microarchitecture in the eye.
In this paper, we describe a new method for constructing macro-scale models of the posterior pole of the eye to investigate the role of intraocular pressure in the development and progression of glaucoma. We also describe a method and present results from micro-scale finite element models of the lamina cribrosa microarchitecture that are derived from parent macro-scale continuum models using a novel multiscale substructuring approach. The laminar micro-scale models capture the biomechanical behavior of the laminar trabeculae in a way that cannot be estimated using macro-scale techniques, and predict much higher stresses and strains than those calculated within macro-scale models of the coincident region in the same eye.
Downs
J Crawford
JC
Ocular Biomechanics Laboratory, Devers Eye Institute, 1225 NE 2nd Avenue, Portland, OR 97232, USA. cdowns@deverseye.org
Roberts
Michael D
MD
Burgoyne
Claude F
CF
Hart
Richard T
RT
D000818:Animals; D016880:Anisotropy; D001369:Axons; D001696:Biomechanical Phenomena; D018450:Disease Progression; D004548:Elasticity; D005123:Eye / Q000503:physiopathology*; D020342:Finite Element Analysis; D005901:Glaucoma / Q000473:pathology* / Q000503:physiopathology; D000882:Haplorhini; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007429:Intraocular Pressure; D012984:Software