title: A novel p53-dependent apoptosis function of TARSH in tumor development.
abstract: A target of NESH-SH3/Abi3bp (TARSH) was originally identified as an SH3 domain-binding molecule of the NESH-SH3/Abi3 protein that is involved in Rac-dependent actin polymerization. In recent studies, TARSH gene expression was dramatically induced in mouse embryonic fibroblasts (MEFs) replicative senescence and suppressed in human lung carcinoma specimens and thyroid carcinomas. However, the molecular mechanism underlying the regulation of TARSH in tumorigenesis remains unclear. Here, we address a p53-dependent apoptosis function of the mouse TARSH gene using RNAi-mediated suppression of endogenous TARSH expression. Our results will be useful in the discovery of a novel therapeutic target in lung carcinoma.
authors.affiliation: Department of Mechanism of Aging, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Wakoh
authors.forename: Masataka
authors.initials: M
authors.lastname: Sugimoto
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Terauchi
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Shimada
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Maruyama
mesh_terms: D000818:Animals; D017209:Apoptosis; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D002453:Cell Cycle; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D041681:NIH 3T3 Cells; D009369:Neoplasms / Q000209:etiology* / Q000517:prevention & control; D012333:RNA, Messenger / Q000032:analysis; D034741:RNA, Small Interfering / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
chemical_list: C439569:ABI3BP protein, human; D002352:Carrier Proteins; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D016159:Tumor Suppressor Protein p53