title: New polyketides from the marine-derived fungus Phaeosphaeria spartinae.
abstract: The fungus Phaeosphaeria spartinae is an endophyte of the marine alga Ceramium sp. Investigation of this marine-derived fungus led to the isolation of the new natural products spartinol A (1), B (2), C (3) and D (4). The structures of these closely related compounds were established from extensive spectroscopic investigations. Compound 3 showed weak inhibition of human leukocyte elastase (HLE).
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany.
authors.forename: Mahmoud Fahmi
authors.initials: MF
authors.lastname: Elsebai
authors.forename: Stefan
authors.initials: S
authors.lastname: Kehraus
authors.forename: Michael
authors.initials: M
authors.lastname: Gütschow
authors.forename: Gabriele M
authors.initials: GM
authors.lastname: König
mesh_terms: D001203:Ascomycota / Q000737:chemistry* / Q000145:classification / Q000254:growth & development; D018533:Biomass; D003470:Culture Media; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D053491:Proteinase Inhibitory Proteins, Secretory / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D003470:Culture Media; D018942:Macrolides; D053491:Proteinase Inhibitory Proteins, Secretory