title: Coagulopathy in critically ill patients: part 1: platelet disorders.
abstract: Abnormalities of platelet number and function are the most common coagulation disorders seen among ICU patients. This article reviews the most frequent causes of thrombocytopenia by providing an overview of the following most common mechanisms: impaired production; sequestration; dilution; and destruction. Guidelines for treating thrombocytopenia and platelet dysfunction are also provided.
authors.affiliation: Medical Intensive Care Unit, Vanderbilt University Medical Center, Nashville, TN.
authors.forename: Todd W
authors.initials: TW
authors.lastname: Rice
authors.affiliation: Medical Intensive Care Unit, Vanderbilt University Medical Center, Nashville, TN; Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN. Electronic address: art.wheeler@vanderbilt.edu.
authors.forename: Arthur P
authors.initials: AP
authors.lastname: Wheeler
mesh_terms: D001778:Blood Coagulation Disorders / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D001791:Blood Platelet Disorders / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D001792:Blood Platelets / Q000502:physiology; D016638:Critical Illness; D006801:Humans; D007362:Intensive Care Units; D013921:Thrombocytopenia / Q000209:etiology / Q000503:physiopathology / Q000628:therapy