title: Correlation between visual acuity and foveal microstructural changes in diabetic macular edema.
abstract: OBJECTIVE
  The purpose of this study was to investigate the correlation between best-corrected visual acuity and foveal microstructural changes of the external limiting membrane and the junction between the inner and outer segments of the photoreceptors in diabetic macular edema.
  
  
  METHODS
  The authors performed spectral-domain optical coherence tomography in all eyes. The authors defined central subfield thickness as the average retinal thickness of the 1-mm central scanned area. The length of disruption of the external limiting membrane and the inner and outer segments of the photoreceptors in the fovea (1.8 mm in diameter) were measured and graded according to their length as follows: 1) >1.4 mm; 2) >0.4 mm but <1.4 mm; or 3) <0.4 mm.
  
  
  RESULTS
  The best-corrected visual acuity was strongly associated with the external limiting membrane (r = 0.66) and inner and outer segments of the photoreceptor (r = 0.68) scores, whereas best-corrected visual acuity was weakly and negatively correlated with central subfield thickness (r = -0.23).
  
  
  CONCLUSIONS
  Spectral-domain optical coherence tomography showed that the integrity of the external limiting membrane and inner and outer segments of the photoreceptors was more strongly correlated with best-corrected visual acuity when compared with central subfield thickness in diabetic macular edema.
authors.affiliation: Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan. otanito@showa.gunma-u.ac.jp
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Otani
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Shoji
authors.initials: S
authors.lastname: Kishi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001485:Basement Membrane / Q000473:pathology; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D005260:Female; D005584:Fovea Centralis; D006801:Humans; D008269:Macular Edema / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D055211:Retinal Photoreceptor Cell Inner Segment / Q000473:pathology*; D055214:Retinal Photoreceptor Cell Outer Segment / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*