title: Session 4: CVD, diabetes and cancer: A dietary portfolio for management and prevention of heart disease.
abstract: CHD is the leading cause of worldwide mortality. The prevalence of heart disease has been linked to the adoption of a sedentary lifestyle and the increased dietary dependence on saturated fats from animal sources and the intake of refined foods. Elevated blood cholesterol level is one of the major risk factors for CHD. While cholesterol-lowering drug therapy (statins) has been effective in reducing the risk of heart disease, there are those individuals who are unwilling or because of muscle pains or raised levels of liver or muscle enzymes are unable to take cholesterol-lowering medication. Fortunately, there is evidence linking a number of dietary components to CHD risk reduction. The strength of this evidence has prompted various regulatory bodies to advocate diet as the first line of defence for primary prevention of heart disease. It was therefore decided to combine four dietary components that have been shown to lower blood cholesterol concentrations (nuts, plant sterols, viscous fibre and vegetable protein) in a dietary portfolio in order to determine whether the combined effect is additive. In a metabolically-controlled setting this dietary portfolio has proved to be as effective as a starting dose of a first-generation statin cholesterol-lowering medication in reducing the risk of CHD. The dietary portfolio has also been shown to be effective in sustaining a clinically-significant effect in the long term under a 'real-world' scenario. However, success of the diet depends on compliance and despite the accessibility of the foods adherence has been found to vary greatly. Overall, the evidence supports the beneficial role of the dietary portfolio in reducing blood cholesterol levels and CHD risk.
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 3E2, Canada.
authors.forename: Amin
authors.initials: A
authors.lastname: Esfahani
authors.forename: David J A
authors.initials: DJ
authors.lastname: Jenkins
authors.forename: Cyril W C
authors.initials: CW
authors.lastname: Kendall
mesh_terms: D002784:Cholesterol / Q000097:blood*; D003327:Coronary Disease / Q000178:diet therapy / Q000209:etiology / Q000517:prevention & control*; D003920:Diabetes Mellitus; D004032:Diet; D004043:Dietary Fiber / Q000627:therapeutic use; D004044:Dietary Proteins / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms; D009754:Nuts; D010840:Phytosterols / Q000627:therapeutic use; D008517:Phytotherapy; D010940:Plant Proteins / Q000627:therapeutic use; D012307:Risk Factors; D014675:Vegetables
chemical_list: D004043:Dietary Fiber; D004044:Dietary Proteins; D010840:Phytosterols; D010940:Plant Proteins; D002784:Cholesterol