Reduction of percutaneous absorption of toxic chemicals by dendrimers.
Polyamidoamine (PAMAM) dendrimer, a reactive nanoparticle, was investigated as a potential protectant against percutaneous absorption of chemicals. Permeation of furfural (model toxicant) through rat skin from a 1-mg/mL solution was studied in the absence and presence of PAMAM dendrimer, which was applied either as 1, 4, and 6 mg/mL in furfural solution (cotreatment) or 2.2 mg/cm(2) deposited on skin surface before furfural application (pretreatment). Furfural flux, about 70 microg/cm(2)/h in untreated samples, was decreased by PAMAM dendrimer in a concentration-dependent manner up to 12 times with the cotreatment methods and 2.3 times with the pretreatment method, indicating PAMAM's protective ability against cutaneous toxicants.
Moghimi
Hamid R
HR
Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti Medical University, Tehran, Iran. hrmoghimi@yahoo.com
Varshochian
Reyhaneh
R
Kobarfard
Farzad
F
Erfan
Mohammad
M
D000279:Administration, Cutaneous; D000818:Animals; D050091:Dendrimers / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005662:Furaldehyde / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity; D007700:Kinetics; D008297:Male; D010539:Permeability; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects*
D050091:Dendrimers; C104700:PAMAM Starburst; D020011:Protective Agents; D005662:Furaldehyde