Tunable antibacterial coatings that support mammalian cell growth.
Bacterial infections present an enormous problem causing human suffering and cost burdens to healthcare systems worldwide. Here we present novel tunable antibacterial coatings which completely inhibit bacterial colonization by Staphylococcus epidermidis but allow normal adhesion and spreading of osteoblastic cells. The coatings are based on amine plasma polymer films loaded with silver nanoparticles. The method of preparation allows flexible control over the amount of loaded silver nanoparticles and the rate of release of silver ions.
Vasilev
Krasimir
K
Mawson Institute, University of South Australia, Mawson Lakes, Adelaide, SA 5095, Australia. krasimir.vasilev@unisa.edu.au
Sah
Vasu
V
Anselme
Karine
K
Ndi
Chi
C
Mateescu
Mihaela
M
Dollmann
Björn
B
Martinek
Petr
P
Ys
Hardi
H
Ploux
Lydie
L
Griesser
Hans J
HJ
D000268:Adhesiveness; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001424:Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control*; D002448:Cell Adhesion; D018929:Cell Culture Techniques; D006801:Humans; D007477:Ions; D053768:Metal Nanoparticles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods; D010006:Osteoblasts / Q000166:cytology / Q000382:microbiology; D011108:Polymers / Q000737:chemistry; D012834:Silver / Q000737:chemistry; D013212:Staphylococcus epidermidis / Q000187:drug effects
D000890:Anti-Infective Agents; D007477:Ions; D011108:Polymers; D012834:Silver