title: The GPIIbIIIa antagonist drugs eptifibatide and tirofiban do not induce activation of apoptosis executioner caspase-3 in resting platelets but inhibit caspase-3 activation in platelets stimulated with thrombin or calcium ionophore A23187.
authors.forename: Valery
authors.initials: V
authors.lastname: Leytin
authors.forename: Asuman
authors.initials: A
authors.lastname: Mutlu
authors.forename: Sergiy
authors.initials: S
authors.lastname: Mykhaylov
authors.forename: David J
authors.initials: DJ
authors.lastname: Allen
authors.forename: Armen V
authors.initials: AV
authors.lastname: Gyulkhandanyan
authors.forename: John
authors.initials: J
authors.lastname: Freedman
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000001:Calcimycin / Q000494:pharmacology*; D053148:Caspase 3 / Q000378:metabolism*; D003029:Coagulants / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D000077542:Eptifibatide; D005434:Flow Cytometry; D006801:Humans; D007476:Ionophores / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D013917:Thrombin / Q000494:pharmacology*; D000077466:Tirofiban; D014443:Tyrosine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D003029:Coagulants; D007476:Ionophores; D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D000001:Calcimycin; D014443:Tyrosine; D013917:Thrombin; D053148:Caspase 3; D000077466:Tirofiban; D000077542:Eptifibatide