Chemical composition and antimicrobial activity of essential oil of Bupleurum montanum and B. plantagineum.
The hydrodistilled oils from the aerial parts of Bupleurum montanum and B. plantagineum, which are endemic to North Africa, including Algeria, were analyzed by gas chromatography-mass spectrometry (GC-MS). Ninety-eight compounds were detected in the oil of B. montanum, representing 98.6% of the total oil, and 68 in the oil of B. plantagineum, representing 99.8% of the total. Megastigma-4,6-(E),8(2)-triene was the major constituent of B. montana oil (25.3%). Other important compounds were myrcene, alpha-pinene and benzyl tiglate. Conversely, the major constituents of the oil of B. plantagineum were alpha-pinene (31.9%), cis-chrysanthenyl acetate (28.2%), and myrcene (24.8%), followed by the monoterpene hydrocarbon limonene (5.1%). The mutagenic, antiplasmodial and antimicrobial activities of the essential oils were individually evaluated against eleven microorganisms, using the agar diffusion method, by determination of MIC values. The investigated oils exhibited moderate antimicrobial activity. Maximum activity of the oils was observed against Nocardia asteroides, Staphylococcus aureus and Enterococcus faecalis. Fungicidal activity against Candida albicans was also found for both oils.
Laouer
Hocine
H
Laboratory of Natural Resources Valorization, Department of Biology, Ferhat Abbas University, Setif, Algeria. hocine_laouer@hotmail.com
Hirèche-Adjal
Yasmina
Y
Prado
Soizic
S
Boulaacheb
Nacira
N
Akkal
Salah
S
Singh
Gurdip
G
Singh
Pratibha
P
Isidorov
Valery A
VA
Szczepaniak
Lech
L
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D029972:Bupleurum / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects; D009822:Oils, Volatile / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects
D000890:Anti-Infective Agents; D000962:Antimalarials; D007202:Indicators and Reagents; D009822:Oils, Volatile