title: Study on the impact of morselized bones on biological binding of HA-coated femoral stem in dogs.
abstract: The impact of the dog's morselized autologous bone implantation into femoral medullary cavity on binding in the hydroxyapatite-coated femoral stem prosthesis-bone interface was studied. Twenty-four adult mongrel dogs were divided into 2 groups: experimental and control. The experimental group's medullary cavity was filled with morselized autologous bone. Artificial femoral-stem replacements at the right side were then carried out. At 1, 3, and 6 months postoperatively, computed tomography (CT) values reflecting changes in bone density were measured. A histological observation to check prosthesis-bone interface contact ratios and bone growth was conducted. Analysis of radiographs of slices was made using Interactive Data Language (IDL; ITT Visual Information Solutions, Boulder, Colorado) software. Results showed that the experimental group fared better than the control group, and the difference was statistically significant (P<.05). Stereomicroscope-based observation showed that the number of trabecular bones in the experimental group was larger than that of the control group, and bone growth of the experimental group was also better than that of the control group. Inverted microscope observation showed that the binding degree between prosthesis and trabecular bone of the experimental group was higher than that of the control group. Comparatively, the experimental group's trabecular bone had more osteogenic cells. The binding between morselized autologous bone and hydroxyapatite-coated femoral stem prosthesis can improve direct bone-contact ratios, and the experimental group's number of newly formed trabecular bone was significantly larger than that of the control group.
authors.affiliation: Department of Orthopedic Surgery, First Clinical Hospital of Harbin Medical University, Youzheng Harbin, Heilongjiang 150001, China.
authors.forename: Ke-guan
authors.initials: KG
authors.lastname: Song
authors.forename: De-sheng
authors.initials: DS
authors.lastname: Ma
authors.forename: Cheng-Kung
authors.initials: CK
authors.lastname: Cheng
authors.forename: Jing-long
authors.initials: JL
authors.lastname: Yan
mesh_terms: D000268:Adhesiveness; D000818:Animals; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004285:Dogs; D019544:Equipment Failure Analysis; D005260:Female; D005269:Femur / Q000502:physiology* / Q000601:surgery*; D008297:Male; D016348:Osseointegration / Q000502:physiology*; D011208:Powders; D011474:Prosthesis Design
chemical_list: D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D011208:Powders