title: [Extraintestinal manifestations in Crohn's disease: risk factors and influence of intestinal surgery].
abstract: BACKGROUND
  Extraintestinal manifestations significantly affect the quality of life of patients with Crohn's disease. The aim of the present study is to define the risk factors for extraintestinal manifestations and the relative influence of intestinal surgery.
  
  
  METHODS
  In a cohort of 223 patients with Crohn's disease we analyzed the association between demographic/clinico-pathological factors and extraintestinal manifestations. In addition, we evaluated their association with the timing of appearance of the extraintestinal manifestations with respect to the intestinal surgery.
  
  
  RESULTS
  Fifty-seven patients (25.6%) developed 91 extraintestinal manifestations. Demographic and clinico-pathological variables significantly associated with extraintestinal manifestations were: female gender (OR 2.84, 95% CI: 1.37-5.90) and colonic involvement (OR 2.68, 95% CI: 1.06-6.76). In patients not undergoing surgery and in patients with extraintestinal manifestations present only before surgery, the latency period between the onset of Crohn'S disease and extraintestinal manifestations were 3.7 +/-8.2 and 2.1 +/- 6.3 years, respectively. In patients developed extraintestinal manifestations only after surgery, the latency between surgery and extraintestinal manifestations was 12.0 +/-10.0 years. In 5 patients with early onset of extraintestinal manifestations, these did not regress or recur after surgery.
  
  
  CONCLUSIONS
  Female gender and colonic involvement are confirmed as risk factors for the development of extraintestinal manifestations in Crohn's disease. Surgical treatment of the intestinal disease represents a therapeutic option for patients with extraintestinal manifestations, as it seems to prevent or delay these manifestations in most cases.
authors.affiliation: Università degli Studi di Brescia, Italia. nascimbr@med.unibs.it
authors.forename: Riccardo
authors.initials: R
authors.lastname: Nascimbeni
authors.forename: Francesco
authors.initials: F
authors.lastname: Di Fabio
authors.forename: Alberto
authors.initials: A
authors.lastname: Lanzini
authors.forename: Francesco
authors.initials: F
authors.lastname: Lanzarotto
authors.forename: Chiara
authors.initials: C
authors.lastname: Ricci
authors.forename: Claudio
authors.initials: C
authors.lastname: Casella
authors.forename: Bruno
authors.initials: B
authors.lastname: Salerni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003424:Crohn Disease / Q000150:complications* / Q000601:surgery; D003627:Data Interpretation, Statistical; D004893:Erythema Nodosum / Q000209:etiology*; D005260:Female; D006801:Humans; D007223:Infant; D007422:Intestines / Q000601:surgery*; D007592:Joint Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000209:etiology*; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors