Structural basis of alpha-fucosidase inhibition by iminocyclitols with K(i) values in the micro- to picomolar range.
Wu
Hsing-Ju
HJ
Institute of Biological Chemistry, CBMB, Taiwan International Graduate Program, Academia Sinica, 128 Section 2, Academia Road, Nankang, Taipei 11529, Taiwan.
Ho
Ching-Wen
CW
Ko
Tzu-Ping
TP
Popat
Shinde D
SD
Lin
Chun-Hung
CH
Wang
Andrew H-J
AH
D017485:1-Deoxynojirimycin; D001419:Bacteria / Q000201:enzymology; D001665:Binding Sites / Q000187:drug effects; D018360:Crystallography, X-Ray; D054812:Cyclitols / Q000138:chemical synthesis* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D013329:Structure-Activity Relationship; D013816:Thermodynamics; D005644:alpha-L-Fucosidase / Q000037:antagonists & inhibitors* / Q000737:chemistry
D054812:Cyclitols; D004791:Enzyme Inhibitors; D017485:1-Deoxynojirimycin; D005644:alpha-L-Fucosidase