Morphologic patterns of human endometrial epithelium in women with uterine myomata treated with leuprorelin acetate.
OBJECTIVE
We studied morphologic modifications of the endometrium induced by leuprorelin acetate, a gonadotropin-releasing hormone agonist, in women with uterine myomata.


METHODS
Transmission and scanning electron microscopy observations were performed after 2 or 6 cycles of therapy (every 28 days).


RESULTS
A near-normal endometrium was observed after 2 months of therapy, while treatment with 6 cycles of leuprorelin acetate induced a uniform morphologic regression of the uterine mucosa.


CONCLUSIONS
The study demonstrates that leuprorelin acetate induces a unique and time-dependent regression of the endometrial mucous membrane.
Palmara
Vittorio
V
Department of Gynaecology, Obstetrics and Physiopathology of the Human Reproduction, University of Messina, Via Consolare Valeria, Messina, Italy. vipalmara@unime.it
Triolo
Onofrio
O
Benedetto
Vincenzo
V
Lo Re
Carmela
C
Sturlese
Emanuele
E
Retto
Giovanni
G
Santoro
Giuseppe
G
D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D004717:Endometrium / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy / Q000473:pathology* / Q000648:ultrastructure; D016729:Leuprolide / Q000008:administration & dosage*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000648:ultrastructure
D018931:Antineoplastic Agents, Hormonal; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide