title: Morphologic patterns of human endometrial epithelium in women with uterine myomata treated with leuprorelin acetate.
abstract: OBJECTIVE
  We studied morphologic modifications of the endometrium induced by leuprorelin acetate, a gonadotropin-releasing hormone agonist, in women with uterine myomata.
  
  
  METHODS
  Transmission and scanning electron microscopy observations were performed after 2 or 6 cycles of therapy (every 28 days).
  
  
  RESULTS
  A near-normal endometrium was observed after 2 months of therapy, while treatment with 6 cycles of leuprorelin acetate induced a uniform morphologic regression of the uterine mucosa.
  
  
  CONCLUSIONS
  The study demonstrates that leuprorelin acetate induces a unique and time-dependent regression of the endometrial mucous membrane.
authors.affiliation: Department of Gynaecology, Obstetrics and Physiopathology of the Human Reproduction, University of Messina, Via Consolare Valeria, Messina, Italy. vipalmara@unime.it
authors.forename: Vittorio
authors.initials: V
authors.lastname: Palmara
authors.forename: Onofrio
authors.initials: O
authors.lastname: Triolo
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Benedetto
authors.forename: Carmela
authors.initials: C
authors.lastname: Lo Re
authors.forename: Emanuele
authors.initials: E
authors.lastname: Sturlese
authors.forename: Giovanni
authors.initials: G
authors.lastname: Retto
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Santoro
mesh_terms: D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D004717:Endometrium / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy / Q000473:pathology* / Q000648:ultrastructure; D016729:Leuprolide / Q000008:administration & dosage*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D018931:Antineoplastic Agents, Hormonal; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide