title: [Effect of direct hemoperfusion with a polymyxin B immobilized fiber column in acute exacerbation of interstitial pneumonia and serum indicators].
abstract: Acute exacerbation of interstitial pneumonia (IP-AE) can occasionally occur and has a poor prognosis. Direct hemoperfusion with a polymyxin B immobilized fiber column (PMX-DHP) has been shown to have a beneficial effect on acute respiratory distress syndrome, which has similar pathological features to that of IP-AE. This study was aimed to investigate the effects of PMX-DHP on IP-AE and serum indicators for epithelial damage. Nine patients with a clinical diagnosis of interstitial pneumonia, who developed acute exacerbation, were included in this study. Five patients had been given a diagnosis of idiopathic pulmonary fibrosis (IPF) and 3 cases were diagnosed as collagen vascular disease-associated interstitial pneumonia (CVD-IP). On days 30 and 60, 6 and 4 patients were surviving, respectively. On day 60, all 3 patients with CVD-IP were alive, while 4 of 5 patients with IPF had died. In 4 patients who survived for 60 days or longer, serum levels of LDH, CRP, and SP-D were significantly decreased after PMX-DHP, whereas KL-6 level was unchanged. In 5 patients, who died by day 60, no significant changes in the serum markers were observed. These data suggest that serum levels of LDH, CRP, and SP-D might be predictive of successful PMX-DHP treatment in cases of IP-AE.
authors.affiliation: Division of Pulmonary Medicine, Keio University School of Medicine.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Sadatomo
authors.initials: S
authors.lastname: Tasaka
authors.forename: Naoki
authors.initials: N
authors.lastname: Hasegawa
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kamata
authors.forename: Hiromi
authors.initials: H
authors.lastname: Shinoda
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kimizuka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kotake
authors.forename: Junzo
authors.initials: J
authors.lastname: Takeda
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Ishizaka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000628:therapy*; D008297:Male; D011112:Polymyxin B; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood
chemical_list: D015415:Biomarkers; D037663:Pulmonary Surfactant-Associated Protein D; D011112:Polymyxin B