Polyacetylenes from Bupleurum longiradiatum.
Eight new polyacetylenes (1-8) and six known polyacetylenes were isolated from the entire parts of Bupleurum longiradiatum, a poisonous plant. The structures of the new compounds were determined by spectroscopic data interpretation. The absolute configuration of the known compound bupleurotoxin (9) was established by the modified Mosher's method. All isolates were also tested for their cytotoxicity against a human leukemia cell line (HL-60).
Huang
Hai-Qiang
HQ
Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China.
Zhang
Xi
X
Shen
Yun-Heng
YH
Su
Juan
J
Liu
Xiao-Hua
XH
Tian
Jun-Min
JM
Lin
Sheng
S
Shan
Lei
L
Zhang
Wei-Dong
WD
D000480:Alkynes; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029972:Bupleurum / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification; D053279:Polyynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000480:Alkynes; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D011090:Polyenes; C055767:bupleurotoxin; D053279:Polyynes