title: Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila.
abstract: Studies in a broad spectrum of model organisms have reported that dietary restriction (DR) is associated with an increase in mitochondrial electron transport chain (ETC) function. However, the question of whether ETC function is required for DR-mediated longevity remains controversial. Here, we report that genetic and pharmacological interventions that target mitochondrial complex V affect Drosophila lifespan in a nutrient-dependent manner. These findings support a requirement for mitochondrial complex V in DR-mediated longevity in flies.
authors.affiliation: Department of Physiological Science, University of California, Los Angeles, CA 90095-1527, USA.
authors.forename: Sepehr
authors.initials: S
authors.lastname: Bahadorani
authors.forename: Jae H
authors.initials: JH
authors.lastname: Hur
authors.forename: Thomas
authors.initials: T
authors.lastname: Lo
authors.forename: Kevin
authors.initials: K
authors.lastname: Vu
authors.forename: David W
authors.initials: DW
authors.lastname: Walker
mesh_terms: D000818:Animals; D031204:Caloric Restriction; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000201:enzymology* / Q000235:genetics; D005786:Gene Expression Regulation; D008136:Longevity; D008928:Mitochondria / Q000201:enzymology*
chemical_list: D029721:Drosophila Proteins