Association between bone mineral density and metabolic syndrome in postmenopausal Korean women.
OBJECTIVE
We investigated the relationship between bone mineral density (BMD) of the femur neck or lumbar spine and metabolic syndrome or its parameters in postmenopausal Korean women.


METHODS
This study included 399 postmenopausal women, for whom the BMD of their L2s-L4s and femur necks were examined in association with metabolic syndrome.


RESULTS
Subjects with metabolic syndrome had a higher BMD of the femur neck than those without metabolic syndrome when adjusted for age (0.85 +/- 0.09 vs. 0.82 +/- 0.12 g/cm(2), p = 0.011), while there was no statistical difference at lumbar spine. When adjusted for age and BMI, high-density lipoprotein cholesterol (HDL-C) was weakly and negatively correlated with BMD of the lumbar and femur neck (r = -0.107, p = 0.033; r = -0.111, p = 0.028 respectively).


CONCLUSIONS
Metabolic syndrome was partly associated with higher BMD in our postmenopausal Korean women. Our study also showed that HDL-C levels were negatively associated with BMD of the lumbar spine and femur neck which means that subjects with lower HDL-C levels could have higher BMD. The results of our retrospective study revealed that metabolic syndrome could be associated with higher BMD in our postmenopausal Korean women.
Park
Kwan Kyu
KK
Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea.
Kim
Sung-Jae
SJ
Moon
Eun Su
ES
D000368:Aged; D015519:Bone Density; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005272:Femur Neck; D006801:Humans; D016014:Linear Models; D008159:Lumbar Vertebrae; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D010024:Osteoporosis / Q000453:epidemiology*; D017698:Postmenopause; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies
D008076:Cholesterol, HDL