Toxoplasma gondii infection and cerebral toxoplasmosis in HIV-infected patients.
Cerebral toxoplasmosis is a major cause of morbidity and mortality among HIV-infected patients, particularly from developing countries. This article summarizes current literature on cerebral toxoplasmosis. It focuses on: Toxoplasma gondii genetic diversity and its possible relationship with disease presentation; host responses to the parasite antigens; host immunosupression in HIV and cerebral toxoplasmosis as well as different diagnostic methods; clinical and radiological features; treatment; and the direction that studies on cerebral toxoplasmosis will likely take in the future.
Pereira-Chioccola
Vera Lucia
VL
Laboratório de Parasitologia, Instituto Adolfo Lutz, CEP 01246-902, São Paulo, SP, Brazil. pchioccola@ial.sp.gov.br
Vidal
José Ernesto
JE
Su
Chunlei
C
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology* / Q000473:pathology; D000818:Animals; D035843:Biomedical Research / Q000639:trends; D014644:Genetic Variation; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D006801:Humans; D014122:Toxoplasma / Q000235:genetics / Q000472:pathogenicity; D016781:Toxoplasmosis, Cerebral / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology* / Q000473:pathology