Elution characteristics of teicoplanin-loaded biodegradable borate glass/chitosan composite.
Local antibiotic delivery system has an advantage over systemic antibiotic for osteomyelitis treatment due to the delivery of high local antibiotic concentration while avoiding potential systemic toxicity. Composite biomaterials with multifunctional roles, consisting of a controlled antibiotic release, a mechanical (load-bearing) function, and the ability to promote bone regeneration, gradually become the most active area of investigation and development of local antibiotic delivery vehicles. In the present study, a composite of borate glass and chitosan (designated BG/C) was developed as teicoplanin delivery vehicle. The in vitro elution kinetics and antibacterial activity of teicoplanin released from BG/C composite as a function of immersion time were determined. Moreover, the pH changes of eluents and the bioactivity of the composite were characterized using scanning electron microscopy coupled with energy-dispersive spectroscopy and X-ray diffraction analysis.
Jia
Wei-Tao
WT
Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Jiaotong University, No. 600, Yishan Road, Shanghai 200233, China.
Zhang
Xin
X
Zhang
Chang-Qing
CQ
Liu
Xin
X
Huang
Wen-Hai
WH
Rahaman
Mohamed N
MN
Day
Delbert E
DE
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D016723:Bone Remodeling / Q000187:drug effects; D001881:Borates / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D005898:Glass / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D010019:Osteomyelitis / Q000188:drug therapy; D017334:Teicoplanin / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D013997:Time Factors; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D001881:Borates; D003692:Delayed-Action Preparations; D017334:Teicoplanin; D048271:Chitosan