title: Metalloproteinases and their inhibitors-diagnostic and therapeutic opportunities in orthopedics.
abstract: Matrix metalloproteinases (MMPs) and related enzymes (ADAMs, ADAMTS) and their inhibitors control matrix turnover and function. Recent advances in our understanding of musculoskeletal conditions such as tendinopathy, arthritis, Dupuytren's disease, degenerative disc disease, and bone and soft tissue healing suggest that MMPs have prominant roles. Importantly, MMPs are amenable to inhibition by cheap, safe, and widely available drugs such as the tetracycline antibiotics and the bisphosphonates. This indicates that these MMP inhibitors, if proven effective for any novel indication, may be quickly brought into clinical practice.
authors.affiliation: Orthopaedics and Sports Medicine, IKE, Linköping University, Linköping, Sweden. bjorn.pasternak@gmail.com
authors.forename: Björn
authors.initials: B
authors.lastname: Pasternak
authors.forename: Per
authors.initials: P
authors.lastname: Aspenberg
mesh_terms: D051722:ADAM Proteins / Q000378:metabolism / Q000627:therapeutic use; D000071097:ADAMTS1 Protein; D001857:Bone Matrix / Q000201:enzymology / Q000502:physiology; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000378:metabolism / Q000627:therapeutic use; D009140:Musculoskeletal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000201:enzymology*; D011379:Prognosis; D013754:Tetracyclines / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D004164:Diphosphonates; D061965:Matrix Metalloproteinase Inhibitors; D013754:Tetracyclines; D051722:ADAM Proteins; D000071097:ADAMTS1 Protein; C103859:ADAMTS1 protein, human; D020782:Matrix Metalloproteinases