Adult final height after GH therapy for irradiation-induced GH deficiency in childhood survivors of brain tumors: the Belgian experience.
OBJECTIVE
The treatment of brain tumors in childhood is frequently complicated by growth retardation with a high proportion of irradiation (Irr)-induced GH deficiency (GHD) resulting in reduced adult final height (AFH) even after GH therapy (GHT). In order to optimize future GHT protocols, more information on the factors influencing the growth response to GH in these children is needed. This retrospective study evaluated AFH and influencing auxological and treatment factors of a standardized daily biosynthetic GHT in childhood survivors of brain tumors with documented GHD after brain Irr.


METHODS
From the Belgian GH Registry, 57 children survivors of a brain tumor outside the hypothalamo-pituitary area with available AFH were stratified into two groups depending on cranial (C-Irr; n=25) or craniospinal (CS-Irr; n=32) Irr.


RESULTS
In the C-Irr patients, results showed an AFH of -0.8 (-2.5, 1.4) SDS (median (range)) and in the CS-Irr patients, results showed a significantly (P<0.001) lower AFH of -1.8 (-4.2, 0.0) SDS. AFH SDS corrected for mid-parental height (MPH) in the C-Irr group was -0.5 (-2.2, 0.9) and -1.5 (-3.6, 0.0) SDS in the CS-Irr group. AFH was positively correlated with age at end of tumor therapy, height SDS at start GHT, height gain SDS first year GHT, and negatively correlated with CS-Irr.


CONCLUSIONS
GHT failed to restore adult height to MPH in nearly half of Irr-induced GHD patients for brain tumor, especially those receiving CS-Irr, irradiated at a younger age or shorter at start GHT.
Beckers
D
D
Division of Pediatric Endocrinology, Department of Pediatrics, Catholic University of Louvain, Avenue G. Therasse, B-5530 Yvoir, Belgium. dominique.beckers@uclouvain.be
Thomas
M
M
Jamart
J
J
Francois
I
I
Maes
M
M
Lebrethon
M C
MC
De Waele
K
K
Tenoutasse
S
S
De Schepper
J
J
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001530:Belgium; D001827:Body Height / Q000187:drug effects* / Q000528:radiation effects; D001932:Brain Neoplasms / Q000532:radiotherapy*; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D005260:Female; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology*; D007223:Infant; D008297:Male; D018579:Patient Selection; D010902:Pituitary Gland / Q000503:physiopathology / Q000528:radiation effects*; D011878:Radiotherapy / Q000009:adverse effects*; D012044:Regression Analysis; D012189:Retrospective Studies; D012737:Sex Factors; D018709:Statistics, Nonparametric; D017741:Survivors
D019382:Human Growth Hormone