title: Roles of phospholipase C isozymes in organogenesis and embryonic development.
abstract: Phosphoinositide metabolism is an important intracellular signaling system that regulates a variety of cellular functions. Phospholipase C (PLC) is a key enzyme in this system. Recent studies on genetically manipulated mice have clarified the functions of PLC in vivo. This review focuses on the roles of PLC in organogenesis and embryonic development.
authors.affiliation: Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Fukami
mesh_terms: D000818:Animals; D005306:Fertilization / Q000502:physiology; D006413:Hematopoietic System / Q000196:embryology; D007107:Immune System / Q000196:embryology; D007527:Isoenzymes / Q000502:physiology; D051379:Mice; D038081:Organogenesis / Q000502:physiology*; D012867:Skin / Q000196:embryology; D010738:Type C Phospholipases / Q000502:physiology*
chemical_list: D007527:Isoenzymes; D010738:Type C Phospholipases