A preliminary controlled trial of cognitive behavioral therapy in clozapine-resistant schizophrenia.
The use of cognitive-behavior therapy (CBT) in addition to antipsychotic regimen to treat persistent psychotic symptoms of schizophrenia is growing. The aim of this study was to compare the efficacy of CBT to a befriending (BF) control group in patients with schizophrenia who are refractory to clozapine. Twenty-one patients completed the 21-week trial. In comparison with the control group, the CBT group showed a significant improvement in the General Psychopathology and total score of the Positive and Negative Syndrome Scale, as well as an improvement of Quality of Life scale. The improvement in psychopathology persisted at 6-month follow-up assessment.
Barretto
Eliza Martha de Paiva
EM
Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo, SP-05403-010, Brazil.
Kayo
Monica
M
Avrichir
Belquiz S
BS
Sa
Antonio Reis
AR
Camargo
Maria das Gracas Miquelutti
Md
Napolitano
Isabel Cristina
IC
Nery
Fabiano Gonçalves
FG
Pinto
Jony Arrais
JA
Bannwart
Silvia
S
Scemes
Silvia
S
Di Sarno
Elaine
E
Elkis
Helio
H
D000328:Adult; D003024:Clozapine / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D004351:Drug Resistance; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D055815:Young Adult
D003024:Clozapine