[Severe systemic lupus erythematosus induced by isoniazide].
The authors report a rare case of low register systemic lupus erythematosus with renal attack and neurological armature by isoniazid. The patient was a 23-year-old woman presenting a lupus induced by isoniazid 1 month after the treatment of pleural tuberculosis. Antinuclear antibodies, anti-native DNA, anti-ENA, anti-Sm, anti-SSa, anti-SSb and antihistone were present. The symptoms included arthralgia, fever, anaemia, pleural effusion, pericarditis and anasarca. She presented a renal and neurological attack, accounting for the gravity of the disease. The treatment consisted of the interruption of the isoniazid and a bolus of methyl-prednisolone during 3 days relayed by an oral corticosteroid. The evolution was favourable after 8 months of corticosteroids.
Rakotoson
J L
JL
Unité de soins, de formations et de recherches de pneumologie, CHU d'Antananarivo, Antananarivo, Madagascar. jrakotoson@yahoo.fr
Randriamanana
D
D
Rakotomizao
J R
JR
Andrianasolo
R
R
Rakotoarivelo
R
R
Andrianarisoa
A C F
AC
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000097:blood; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects* / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D008181:Lupus Nephritis / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy; D008270:Madagascar; D008775:Methylprednisolone / Q000627:therapeutic use; D014396:Tuberculosis, Pleural / Q000188:drug therapy*; D055815:Young Adult
D000893:Anti-Inflammatory Agents; D000974:Antibodies, Antinuclear; D000995:Antitubercular Agents; D007538:Isoniazid; D008775:Methylprednisolone