title: Clinical analysis of Castleman disease (hyaline vascular type) in parotid and neck region.
abstract: OBJECTIVE
  The aim of this study was to analyze a single institution's experience in clinical diagnosis, treatment, and prognosis of Castleman disease (hyaline vascular type) in the parotid and neck region.
  
  
  METHODS
  From 2004 to 2008, a total of 10 consecutive patients with Castleman disease (hyaline vascular type) in the parotid and neck region underwent surgery were included in this retrospective study. The preoperative examinations, clinical diagnosis, surgical treatment, and prognosis were recorded and analyzed.
  
  
  RESULTS
  Of the 10 patients, 4 were males and 6 female; their age ranged from 13 to 54 years with a mean of 26.6 years. The lesion occurred in the parotid region in 3 patients, in the neck region in 5 patients, and in both the parotid and neck regions in 2 patients. Their course of disease ranged from 3 months to 48 months with a mean of 12.5 months; 70% of the patients (7 out of 10) had a course of disease of <12 months. The patients always had no obvious complaint, and the laboratory examinations were almost within the normal limits. Magnetic resonance imaging/angiography were valuable on clinical diagnosis and differential diagnosis. All patients underwent surgical removal of the masses completely. During the follow-up period, which ranged from 9 months to 60 months with a mean of 38.9 months, no recurrence of the lesion occurred, and the quality of life of each patient was good.
  
  
  CONCLUSIONS
  Castleman disease (hyaline vascular type) in the parotid and neck region is rare, with clinical manifestation and physical examination the same as benign lesions. There is no specific indication in the laboratory tests and imaging examinations; however, magnetic resonance imaging/angiography has potential value on clinical diagnosis and differential diagnosis. Surgical resection is the choice of treatment with good prognosis.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Ninth People's Hospital, Shanghai, China.
authors.forename: Lai-ping
authors.initials: LP
authors.lastname: Zhong
authors.forename: Li-zhen
authors.initials: LZ
authors.lastname: Wang
authors.forename: Tong
authors.initials: T
authors.lastname: Ji
authors.forename: Yu-hua
authors.initials: YH
authors.lastname: Hu
authors.forename: Yong-jie
authors.initials: YJ
authors.lastname: Hu
authors.forename: Wei-min
authors.initials: WM
authors.lastname: Ye
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.forename: Han-guang
authors.initials: HG
authors.lastname: Zhu
authors.forename: Jiang
authors.initials: J
authors.lastname: Li
authors.forename: Chen-Ping
authors.initials: CP
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D005871:Castleman Disease / Q000145:classification / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000000981:diagnostic imaging; D010306:Parotid Gland; D011859:Radiography; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult