Grandmultiparity and pregnancy outcome in Aba, Nigeria: a case-control study.
OBJECTIVE
To compare the incidence of antenatal and intrapartum complications and perinatal outcomes among women who had delivered five or more times (grandmultiparous) with those of age-matched controls who had delivered two to four times (multiparous).


METHODS
A case-control study.


METHODS
A tertiary referral hospital in Aba, Nigeria.


METHODS
Seven hundred and thirty-four grandmultiparous women were compared with 734 age-matched multiparous controls.


METHODS
Maternal case records were retrieved from medical records department and analyzed with additional information obtained from the labor ward records. Statistical analysis was done using EPI info version 6; χ² test was used to analyze categorical variables.


RESULTS
Grandmultiparity was associated with a significantly higher risk of antenatal anemia (P < 0.05), multiple pregnancy (P < 0.01), fetal macrosomia (P < 0.01), perinatal mortality (P < 0.01), and primary postpartum hemorrhage (P < 0.05). A significantly higher rate of cesarean deliveries was observed in the multiparous controls (P < 0.01), than the grandmultiparous women.


CONCLUSIONS
Our study shows that there is an increased risk of antenatal anemia, multiple pregnancy, primary postpartum hemorrhage, and adverse perinatal outcomes in grandmultiparous women independent of maternal age.
Akwuruoha
E
E
Abia State University Teaching Hospital, Aba, Nigeria.
Kamanu
C
C
Onwere
Stephen
S
Chigbu
B
B
Aluka
C
C
Umezuruike
C
C
D000328:Adult; D016022:Case-Control Studies; D036861:Delivery, Obstetric; D004522:Educational Status; D005260:Female; D006801:Humans; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D010298:Parity; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000209:etiology; D011256:Pregnancy Outcome