Role of testosterone/estradiol ratio in predicting the efficacy of tamoxifen citrate treatment in idiopathic oligoasthenoteratozoospermic men.
OBJECTIVE
It was the aim of this study to investigate the effect of a low testosterone/estradiol (T/E2) ratio and the normalization of this ratio by an aromatase inhibitor, anastrozole, on the treatment results of tamoxifen citrate (TAM) in idiopathic oligoasthenoteratozoospermic patients with a normal T/E2 ratio.


METHODS
127 normogonadotropic men were included in this study. TAM (10 mg twice daily) was applied to 103 of the patients (group 1). The control group consisted of 25 patients who did not receive any treatment (group 2). After 3 months, TAM therapy was continued in 42 of the patients with a normal T/E2 ratio (group 1A). Of the remaining 61 patients with low ratios, 30 continued with TAM (group 1BTAM), while the remaining 31 patients underwent additional anastrozole therapy (1 mg/day) to TAM (group 1BANA).


RESULTS
In the 3rd month of the study, while the sperm concentration and motility were found significantly improved in group 1 (p < 0.05), they were significantly lower in groups 1BTAM and 1BANA than in group 1A (p < 0.01). In the 6th month of the study, the mean T/E2 ratio was normal in group 1A and group 1BANA, but was lower than normal ranges in group 1BTAM. The sperm concentration and motility significantly increased in groups 1A and 1BANA (p < 0.05).


CONCLUSIONS
A significant decrease in the T/E2 ratio was seen in the majority of the patients during TAM treatment. Normalization of this ratio by addition of anastrozole to the treatment regimen improved the treatment outcomes. However, a placebo-controlled study is needed to confirm our results.
Cakan
Murat
M
Department of 2nd Urology, SB Ankara Dişkapi Training Hospital, Ankara, Turkey. muratcakandr@yahoo.com
Aldemir
Mustafa
M
Topcuoglu
Murat
M
Altuğ
Uğur
U
D000328:Adult; D000077384:Anastrozole; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood*; D006801:Humans; D008297:Male; D009570:Nitriles / Q000627:therapeutic use*; D009845:Oligospermia / Q000097:blood* / Q000188:drug therapy*; D011237:Predictive Value of Tests; D013081:Sperm Motility; D013094:Spermatozoa / Q000002:abnormalities*; D013629:Tamoxifen / Q000627:therapeutic use*; D013739:Testosterone / Q000097:blood*; D014230:Triazoles / Q000627:therapeutic use*
D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D013629:Tamoxifen; D000077384:Anastrozole; D013739:Testosterone; D004958:Estradiol