title: A new 5-acyl-2-methylpyrrole from the endophytic fungus S20 of Cephalotaxus hainanensis.
abstract: A new 5-acyl-2-methylpyrrole, isolated from the endophytic fungus S20 of Cephalotaxus hainanensis, was elucidated as 1-(5-methyl-1H-pyrrol-2-yl)-2-((2S*,3R*)-3-((E)-prop-1-enyl)oxiran-2-yl)ethanone (1) on the basis of spectroscopic evidence, including 1D- and 2D-NMR (HMQC, 1H-1H COSY, HMBC and ROESY) and MS analysis. Compound 1 showed inhibitory effects on Staphylococcus aureus and methicillin-resistant S. aureus by the filter paper disc agar diffusion method.
authors.affiliation: Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, Hainan, PR China.
authors.forename: Wen-jun
authors.initials: WJ
authors.lastname: Dai
authors.forename: Hao-fu
authors.initials: HF
authors.lastname: Dai
authors.forename: Jiao
authors.initials: J
authors.lastname: Wu
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Wen-li
authors.initials: WL
authors.lastname: Mei
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D032483:Cephalotaxus / Q000382:microbiology*; D005027:Ethylene Oxide / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000737:chemistry* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: C546647:1-(5-methyl-1H-pyrrol-2-yl)-2-((2S,3R)-3-((E)-prop-1-enyl)oxiran-2-yl)ethanone; D000900:Anti-Bacterial Agents; D011758:Pyrroles; D005027:Ethylene Oxide