title: Obsessive-compulsive disorder associated with parietal white matter multiple sclerosis plaques.
abstract: We report the case of a patient who developed obsessive-compulsive symptoms after being diagnosed with multiple sclerosis. In this patient, obsessive-compulsive symptoms deteriorated with the emergence of a right parietal white matter multiple sclerosis plaque. The involvement of parietal white matter abnormalities in the pathophysiology of obsessive-compulsive disorder remains largely unexplored. Our case report raises the possibility that parietal lobe white matter microstructure plays a role in mediating obsessions and compulsions through disruptions of the functional connectivity between cortical-cortical and/or cortical-subcortical brain regions implicated in the pathophysiology of obsessive-compulsive disorder.
authors.affiliation: National and Kapodistrian University of Athens, Medical School, Second Department of Psychiatry, Attikon General Hospital, Athens, Greece.
authors.forename: Athanassios
authors.initials: A
authors.lastname: Douzenis
authors.forename: Panayiota G
authors.initials: PG
authors.lastname: Michalopoulou
authors.forename: Constantine
authors.initials: C
authors.lastname: Voumvourakis
authors.forename: Maria
authors.initials: M
authors.lastname: Typaldou
authors.forename: Ioannis
authors.initials: I
authors.lastname: Michopoulos
authors.forename: Lefteris
authors.initials: L
authors.lastname: Lykouras
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000150:complications* / Q000473:pathology*; D009771:Obsessive-Compulsive Disorder / Q000150:complications* / Q000175:diagnosis*; D010296:Parietal Lobe / Q000473:pathology*