title: Granulocyte colony-stimulating factor increases the platelet volume in peripheral stem cell apheresis donors.
abstract: We investigated the short-term influence of granulocyte colony-stimulating factor (G-CSF) administration on platelet counts and platelet indices in 12 donors (8 males and 4 females; median age 34 years, range 16-49) for peripheral stem cell transplantation using an automated blood cell analyzer. On day 3 (D3) compared with D0, 11 donors with normal laboratory and physical findings showed increases in platelet indices (chi(2) = 12.0, p = 0.0025). Furthermore, mean platelet volume (MPV) was significantly increased (p = 0.04). Also, platelet count decreased, and platelet distribution width and platelet-large cell ratio were increased, but these were not significant. On the contrary, 1 donor with abnormal laboratory findings who had large platelets (MPV 11.4 fl) before G-CSF administration showed decreases in platelet indices (MPV 10.3 fl) on D3, although platelet count (18.2 x 10(4)/microl) decreased after G-CSF administration. G-CSF administration induces an inflammatory process with endothelial cell activation. This is probably the reason why platelet volume increases after G-CSF use. This is the first report showing that G-CSF administration immediately induces increases in large platelets in peripheral stem cell transplant donors before harvest.
authors.affiliation: Department of Hematology, Fukuyama Chuo Hospital, Hiroshima, Japan. a-ihara @ ken-o-gr.jp
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ihara
authors.forename: Keiko
authors.initials: K
authors.lastname: Matsui
authors.forename: Ryouta
authors.initials: R
authors.lastname: Minami
authors.forename: Shuzou
authors.initials: S
authors.lastname: Uchida
authors.forename: Shuji
authors.initials: S
authors.lastname: Ueda
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nishiura
mesh_terms: D000293:Adolescent; D000328:Adult; D001772:Blood Cell Count / Q000295:instrumentation; D001781:Blood Component Removal / Q000379:methods*; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects*; D048430:Cell Shape / Q000187:drug effects; D048429:Cell Size / Q000187:drug effects; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D010976:Platelet Count; D013997:Time Factors; D055815:Young Adult
chemical_list: D016179:Granulocyte Colony-Stimulating Factor