Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect.
BACKGROUND
Theta cordance is a novel quantitative electroencephalography (QEEG) measure that correlates with cerebral perfusion. A series of clinical studies has demonstrated that the prefrontal theta cordance value decreases after 1 week of treatment in responders to antidepressants and that this effect precedes clinical improvement. Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, has a unique rapid antidepressant effect but its influence on theta cordance is unknown.


METHODS
In a double-blind, cross-over, placebo-controlled experiment we studied the acute effect of ketamine (0.54 mg/kg within 30 min) on theta cordance in a group of 20 healthy volunteers.


RESULTS
Ketamine infusion induced a decrease in prefrontal theta cordance and an increase in the central region theta cordance after 10 and 30 min. The change in prefrontal theta cordance correlated with ketamine and norketamine blood levels after 10 min of ketamine infusion.


CONCLUSIONS
Our data indicate that ketamine infusion immediately induces changes similar to those that monoamineric-based antidepressants induce gradually. The reduction in theta cordance could be a marker and a predictor of the fast-acting antidepressant effect of ketamine, a hypothesis that could be tested in depressive patients treated with ketamine.
Horacek
J
J
Prague Psychiatric Centre, Prague, Czech Republic. horacek@pcp.lf3.cuni.cz
Brunovsky
M
M
Novak
T
T
Tislerova
B
B
Palenicek
T
T
Bubenikova-Valesova
V
V
Spaniel
F
F
Koprivova
J
J
Mohr
P
P
Balikova
M
M
Hoschl
C
C
D000328:Adult; D000339:Affect / Q000187:drug effects; D000778:Anesthetics, Dissociative / Q000097:blood / Q000494:pharmacology*; D015415:Biomarkers; D018592:Cross-Over Studies; D003866:Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D007649:Ketamine / Q000031:analogs & derivatives / Q000097:blood / Q000494:pharmacology*; D008297:Male; D011237:Predictive Value of Tests; D017397:Prefrontal Cortex / Q000187:drug effects*; D013826:Theta Rhythm / Q000187:drug effects*
D000778:Anesthetics, Dissociative; D015415:Biomarkers; D007649:Ketamine; C033419:norketamine