HLA-DRB association in neuromyelitis optica is different from that observed in multiple sclerosis.
Until recently, neuromyelitis optica (NMO) was considered to be a sub-type of multiple sclerosis (MS), which has a strong predilection for Caucasian populations, whereas NMO is more frequent in non-Caucasian individuals. The objective of this study was to compare the HLA-DRB profile in Brazilian Mulatto patients with NMO spectrum disorders (NMOSDs) with that observed for Mulatto MS patients and healthy Mulatto controls. Twenty seven NMOSD patients (20 women), all seropositive for NMO-IgG, 29 MS patients and 28 Mulatto healthy blood donors were evaluated for HLA-DRB allele groups. HLA-DRB1*03 allele group was overrepresented in NMO patients compared with healthy controls (p = 0.0401; OR = 3.23, 95%CI: 1.07-9.82). In contrast, the HLA-DRB1*15 allele group was overrepresented in Brazilian MS patients (OR = 15.89, 95%CI: 3.51-71.85; p < 0.0001). DRB3 was overrepresented in NMO (p = 0.0064), and DRB5 overrepresented in MS patients (p = 0.0001). The low frequency of HLA-DRB1*15 alleles was associated with the presence of long and central cord lesions at magnetic resonance. In addition, DRB1*15 alleles were associated with the fulfillment of the Barkhof criteria. In conclusion, these results indicate that the DRB profile of NMO patients is different from that observed for MS patients, further corroborating the distinction between NMO and MS.
Brum
Doralina Guimaraães
DG
Division Neurology, Department of Neurosciences, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Barreira
Amilton Antunes
AA
dos Santos
Antonio Carlos
AC
Kaimen-Maciel
Damacio Ramon
DR
Matiello
Marcelo
M
Costa
Roberta Martins
RM
Deghaide
Neifi Hassan Saloun
NH
Costa
Laudo Silva
LS
Louzada-Junior
Paulo
P
Diniz
Paula Rejane Beserra
PR
Comini-Frota
Elizabeth Regina
ER
Mendes-Junior
Celso Teixeira
CT
Donadi
Eduardo Antonio
EA
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000483:Alleles; D001782:Blood Donors; D001938:Brazil / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D009471:Neuromyelitis Optica / Q000453:epidemiology / Q000235:genetics*
D006684:HLA-DR Antigens; D007074:Immunoglobulin G