PC3 is involved in the shift from proliferation to differentiation and maturation in spiral ganglion neurons.
PC3 is a member of the BTG/Tob family of antiproliferative genes. Here, we report the results of an analysis of PC3 protein expression in spiral ganglion neurons of the rat cochlea at embryonic days 16 (E16) and 20 (E20), and postnatal days 4 (P4) and 7 (P7). PC3 expression was observed in the cytoplasm of ganglion neurons at E16 and E20, and this protein had translocated to the nucleus by P4. The expression of Ki-67, a nuclear antigen expressed by dividing cells, was detected in ganglion neurons at E16 and E20, but not at P4 or P7. These results suggest that PC3 is involved in the shift from proliferation to differentiation and maturation in the ganglion neurons of the rat cochlea.
Hayashida
Momoko
M
Department of Otolaryngology-Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, 1-1-1 Honjo, Kumamoto city, Japan.
Minoda
Ryosei
R
Shinmyo
Yohei
Y
Ohta
Kunimasa
K
Tanaka
Hideaki
H
Yumoto
Eiji
E
D021581:Active Transport, Cell Nucleus / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism; D049109:Cell Proliferation; D003051:Cochlea / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D017874:Immediate-Early Proteins / Q000235:genetics / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000235:genetics / Q000378:metabolism; D055495:Neurogenesis / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011984:Sensory Receptor Cells / Q000166:cytology / Q000378:metabolism*; D013136:Spiral Ganglion / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
C521959:BTG2 protein, rat; D017874:Immediate-Early Proteins; D019394:Ki-67 Antigen; D025521:Tumor Suppressor Proteins