Obsessive-compulsive disorder associated with parietal white matter multiple sclerosis plaques.
We report the case of a patient who developed obsessive-compulsive symptoms after being diagnosed with multiple sclerosis. In this patient, obsessive-compulsive symptoms deteriorated with the emergence of a right parietal white matter multiple sclerosis plaque. The involvement of parietal white matter abnormalities in the pathophysiology of obsessive-compulsive disorder remains largely unexplored. Our case report raises the possibility that parietal lobe white matter microstructure plays a role in mediating obsessions and compulsions through disruptions of the functional connectivity between cortical-cortical and/or cortical-subcortical brain regions implicated in the pathophysiology of obsessive-compulsive disorder.
Douzenis
Athanassios
A
National and Kapodistrian University of Athens, Medical School, Second Department of Psychiatry, Attikon General Hospital, Athens, Greece.
Michalopoulou
Panayiota G
PG
Voumvourakis
Constantine
C
Typaldou
Maria
M
Michopoulos
Ioannis
I
Lykouras
Lefteris
L
D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000150:complications* / Q000473:pathology*; D009771:Obsessive-Compulsive Disorder / Q000150:complications* / Q000175:diagnosis*; D010296:Parietal Lobe / Q000473:pathology*