Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels.
Besides their role in the generation of action potentials, voltage-gated potassium channels are implicated in cellular processes ranging from cell division to cell death. The K(+) channel regulator protein (KCNRG), identified as a putative tumor suppressor, reduces K(+) currents through human K(+) channels hKv1.1 and hKv1.4 expressed in Xenopus oocytes. Current attenuation requires the presence of the N-terminal T1 Domain and immunoprecipitation experiments suggest association of KCNRG with the N-terminus of the channel. Our data indicates that KCNRG is an ER-associated protein, which we propose regulates Kv1 family channel proteins by retaining a fraction of channels in endomembranes.
Usman
Hyder
H
National Centre for Biological Sciences, Tata Institute of Fundamental Research, UAS-GKVK Campus, Bellary Road, Bangalore-560065, India.
Mathew
M K
MK
D000200:Action Potentials; D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D047468:Immunoprecipitation; D051662:Kv1.1 Potassium Channel / Q000235:genetics / Q000378:metabolism*; D051665:Kv1.4 Potassium Channel / Q000235:genetics / Q000378:metabolism*; D009865:Oocytes; D015221:Potassium Channels / Q000235:genetics / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D014981:Xenopus
C496977:KCNA4 protein, human; C473317:KCNRG protein, human; D051665:Kv1.4 Potassium Channel; D015221:Potassium Channels; D051662:Kv1.1 Potassium Channel