title: Hydrofiber dressing with silver for the management of split-thickness donor sites: a randomized evaluation of two protocols of care.
abstract: BACKGROUND
  This randomized, open-label study evaluated Aquacel Ag Hydrofiber dressing with silver (HDS; ConvaTec, Skillman, NJ, USA) with an adherent or gelled protocol in the management of split-thickness donor sites.
  
  
  METHODS
  HDS was the primary dressing in the adherent group (gauze as secondary covering) and gelled group (transparent film as secondary covering). Dressings were changed on study day 1 or 2 and study days 5 (optional), 10 (optional), and 14. The primary outcome was healing (>or=90% re-epithelialization) at study day 14.
  
  
  RESULTS
  Seventy subjects were treated (36 adherent, 34 gelled). By study day 14, 77% of donor sites had healed (67% adherent, 88% gelled). Pain scores decreased over time in both treatment groups. Investigators were "very satisfied" or "satisfied" with (adherent, gelled) time required to manage dressing change (89%, 79% of subjects), minimization of donor-site pain (64%, 82%), ease of application (97%, 94%), management of drainage (92%, 82%), ease of removal (77%, 85%), and ability of dressing to remain in place (69%, 76%). Thirty-nine (56%) subjects had adverse events, most commonly non-donor-site infection (11%) and gastrointestinal events (11%).
  
  
  CONCLUSIONS
  In this randomized, open-label study, HDS was well-tolerated, versatile, and effective in the management of split-thickness donor sites.
authors.affiliation: Lehigh Valley Hospital, Regional Burn Center, Allentown, PA 18103-6218, USA. sigri.blome-eberwein@lvh.com
authors.forename: S
authors.initials: S
authors.lastname: Blome-Eberwein
authors.forename: R M
authors.initials: RM
authors.lastname: Johnson
authors.forename: S F
authors.initials: SF
authors.lastname: Miller
authors.forename: D M
authors.initials: DM
authors.lastname: Caruso
authors.forename: M H
authors.initials: MH
authors.lastname: Jordan
authors.forename: S
authors.initials: S
authors.lastname: Milner
authors.forename: E E
authors.initials: EE
authors.lastname: Tredget
authors.forename: K M
authors.initials: KM
authors.lastname: Sittig
authors.forename: L
authors.initials: L
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001458:Bandages; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004337:Drug Carriers; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain; D018030:Silver Compounds / Q000627:therapeutic use*; D016038:Skin Transplantation; D014945:Wound Healing; D014947:Wounds and Injuries / Q000601:surgery*; D055815:Young Adult
chemical_list: D004337:Drug Carriers; D018030:Silver Compounds; D002266:Carboxymethylcellulose Sodium