Co-existence of gastrointestinal stromal tumors with malign epithelial tumors: a report of two cases.
OBJECTIVE
To emphasize the importance of a detailed observation for incidental simultaneous tumoral masses during surgery for gastrointestinal stromal tumors (GISTs) at any location in the gastrointestinal system.


METHODS
Case 1: a 39-year-old female patient with an esophageal squamous cell carcinoma and a synchronous small intestinal GIST discovered incidentally during esophagectomy. Case 2: a 73-year-old female patient with a gastric GIST and a synchronous colorectal cancer detected incidentally during gastrectomy. In both cases, immunohistochemical examinations of the resected specimens confirmed the coexistences of GISTs and epithelial malignancies.


CONCLUSIONS
The coexistences of GISTs with epithelial tumors have been increasing in recent years. In any case of a GIST or gastrointestinal adenocarcinoma, the surgeon should be alert to recognize a possible coexistent tumor with different histological origin.
Firat
O
O
Department of General Surgery, Ege University School of Medicine, Izmir, Turkey. ozgur.firat@ege.edu.tr
Yazici
P
P
Makay
O
O
Aydin
A
A
Tuncyurek
M
M
Ersin
S
S
Guler
A
A
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology; D017809:Fatal Outcome; D005260:Female; D005743:Gastrectomy; D046152:Gastrointestinal Stromal Tumors / Q000453:epidemiology* / Q000378:metabolism / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D033162:Incidental Findings; D007580:Jejunal Neoplasms / Q000453:epidemiology*; D008113:Liver Neoplasms / Q000556:secondary; D016609:Neoplasms, Second Primary / Q000453:epidemiology*