title: Secondary metabolites from the mangrove endophytic fungus Penicillium sp. (SBE-8).
abstract: A new metabolite, 7-hydroxyjanthinone (1), was isolated from the mangrove endophytic fungus Penicillium sp. (SBE-8), together with two known compounds, janthinone (2) and citrinin (3). The structures of these compounds were identified by spectroscopic methods. Compounds 1 and 2 showed no cytotoxicity against KB and KBv cell lines when tested by the MTT method, but compound 3 was weakly active.
authors.affiliation: Hubei Key Laboratory of Natural Products Research and Development (China Three Gorges University), Yichang, Hubei Province 443002, People's Republic of China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Guo
authors.forename: Fan
authors.initials: F
authors.lastname: Cheng
authors.forename: Kun
authors.initials: K
authors.lastname: Zou
authors.forename: Junzhi
authors.initials: J
authors.lastname: Wang
authors.forename: Zhigang
authors.initials: Z
authors.lastname: She
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000737:chemistry*; D004396:Coloring Agents; D005285:Fermentation; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D010407:Penicillium / Q000737:chemistry* / Q000378:metabolism*; D043982:Rhizophoraceae / Q000382:microbiology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: C546646:7-hydroxyjanthinone; D000903:Antibiotics, Antineoplastic; D004396:Coloring Agents; D006575:Heterocyclic Compounds, 3-Ring; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue