The cerebellar microcircuit as an adaptive filter: experimental and computational evidence.
Initial investigations of the cerebellar microcircuit inspired the Marr-Albus theoretical framework of cerebellar function. We review recent developments in the experimental understanding of cerebellar microcircuit characteristics and in the computational analysis of Marr-Albus models. We conclude that many Marr-Albus models are in effect adaptive filters, and that evidence for symmetrical long-term potentiation and long-term depression, interneuron plasticity, silent parallel fibre synapses and recurrent mossy fibre connectivity is strikingly congruent with predictions from adaptive-filter models of cerebellar function. This congruence suggests that insights from adaptive-filter theory might help to address outstanding issues of cerebellar function, including both microcircuit processing and extra-cerebellar connectivity.
Dean
Paul
P
Department of Psychology, University of Sheffield, Western Bank, Sheffield, S10 2TP, UK.
Porrill
John
J
Ekerot
Carl-Fredrik
CF
Jörntell
Henrik
H
D000818:Animals; D002531:Cerebellum / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D013569:Synapses / Q000502:physiology