title: Does regional lymph node irradiation improve the outcome of N0 and pN0 breast cancer?
abstract: This study compares the outcome of 76 patients with N0 breast carcinoma, node-negative at axillary lymph node dissection (pN0) after neoadjuvant chemotherapy (NeoCT), treated with (RLNI+, 39 patients) or without (RLNI-, 37 patients) elective regional lymph node areas irradiation. For RLNI- and RLNI+ groups respectively at 10 years, survival without local-regional recurrence was 95% and 91% (p = .59), survival without distant metastasis was 97% and 78% (p = .018) and overall survival was 96% and 75% (p = .013). Clinical size < 4 cm was a strong pronostic factor.
authors.affiliation: Department of Radiation Oncology, Centre Jean Perrin, Clermont-Ferrand F-63011, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Gilliot
authors.forename: Xavier
authors.initials: X
authors.lastname: Durando
authors.forename: Catherine
authors.initials: C
authors.lastname: Abrial
authors.forename: Aurélie
authors.initials: A
authors.lastname: Bellière
authors.forename: Pierre
authors.initials: P
authors.lastname: Gimbergues
authors.forename: Emilie
authors.initials: E
authors.lastname: Thivat
authors.forename: Eloïse
authors.initials: E
authors.lastname: Planchat
authors.forename: Michel
authors.initials: M
authors.lastname: Lapeyre
authors.forename: Fabrice
authors.initials: F
authors.lastname: Kwiatkowski
authors.forename: Ivan
authors.initials: I
authors.lastname: Toledano
authors.forename: Philippe
authors.initials: P
authors.lastname: Chollet
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Nabholtz
authors.forename: Pierre
authors.initials: P
authors.lastname: Verrelle
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000532:radiotherapy*; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D018714:Radiotherapy, Adjuvant; D016019:Survival Analysis