title: A rice variety (HYJA-Ri4) enhances arterial thrombus formation in an animal model of thrombosis.
abstract: Epidemiological evidence exists for a causative role of inappropriate diets in the development and clinical outcome of thrombotic diseases. Our previous studies have shown that some fruits and vegetables have antithrombotic activity. As rice is a principal ingredient of everyday food in Japan, the aim of the present study was to determine rice varieties with antithrombotic effect. Western-style high-fat diet containing flour prepared from whole-grain rice of different varieties was fed to atherosclerosis-prone (apolipoprotein E- and low density lipoprotein receptor-deficient) mice for 3 months. A laser-induced carotid-artery thrombosis model was used. None of the five tested rice varieties showed an antithrombotic effect. The effect of HYJA-Ri1, HYJA-Ri2, HYJA-Ri3 and HYJA-Ri5 rice on experimental thrombus formation did not differ significantly from the controls. However, HYJA-Ri4 rice significantly enhanced the thrombotic reaction (p = 0.0078), thus having a prothrombotic effect. Our findings suggest that HYJA-Ri4 rice should not be included in an antithrombotic diet.
authors.affiliation: Laboratory of Physiology, Faculty of Nutrition and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 651-2180, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Naemura
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Ijiri
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Kodama
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Honda
authors.forename: Junichiro
authors.initials: J
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency; D002340:Carotid Artery Diseases; D004032:Diet; D004195:Disease Models, Animal; D051379:Mice; D012275:Oryza / Q000009:adverse effects*; D011973:Receptors, LDL / Q000172:deficiency; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control*
chemical_list: D001057:Apolipoproteins E; D011973:Receptors, LDL