title: Effect of sodium ferulate on the hyperalgesia mediated by P2X3 receptor in the neuropathic pain rats.
abstract: Neuropathic pain is usually persistent and there is no effective treatment. Activation of P2X(3) receptor subtype in primary sensory neurons is involved in neuropathic pain. Sodium ferulate (SF) is an active principle from Chinese herbal medicine and has anti-inflammatory activities. This study observed the effects of SF on the hyperalgesia mediated by P2X(3) receptor of rats after chronic constriction injury (CCI). Mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were measured and the expression of P2X(3) receptor immunoreactivity and protein in dorsal root ganglion (DRG) neurons was analyzed by immunohistochemistry and western blotting. In CCI rats treated with SF, the MWT and TWL were increased compared with CCI rats treated with normal saline. The expression of P2X(3) receptor in DRG neurons was increased after CCI. In CCI rats treated with SF, the up-regulated expression of P2X(3) receptor in DRG neurons was reduced. SF may reduce the thermal and mechanical hyperalgesia in CCI rat model by decreasing the pain transmitted by primary afferant neurons mediated by P2X(3) receptor during the chronic neuropathic pain injury.
authors.affiliation: Department of Physiology, Basic Medical College of Nanchang University, Nanchang, Jiangxi 330006, PR China.
authors.forename: Aixia
authors.initials: A
authors.lastname: Zhang
authors.forename: Yun
authors.initials: Y
authors.lastname: Gao
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Zhong
authors.forename: Changshui
authors.initials: C
authors.lastname: Xu
authors.forename: Guilin
authors.initials: G
authors.lastname: Li
authors.forename: Shuangmei
authors.initials: S
authors.lastname: Liu
authors.forename: Jiari
authors.initials: J
authors.lastname: Lin
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Han
authors.initials: H
authors.lastname: Liu
authors.forename: Shangdong
authors.initials: S
authors.lastname: Linag
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002908:Chronic Disease / Q000188:drug therapy; D003373:Coumaric Acids / Q000494:pharmacology*; D005727:Ganglia, Spinal / Q000187:drug effects / Q000378:metabolism; D006930:Hyperalgesia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D010147:Pain Measurement; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D010812:Physical Stimulation; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D018048:Receptors, Purinergic P2 / Q000378:metabolism*; D058477:Receptors, Purinergic P2X3; D013696:Temperature; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D000700:Analgesics; D003373:Coumaric Acids; C546410:P2rx3 protein, rat; D018048:Receptors, Purinergic P2; D058477:Receptors, Purinergic P2X3; C004999:ferulic acid