title: Effects of resistance training on resistin, leptin, cytokines, and muscle force in elderly post-menopausal women.
abstract: It may be that resistance exercise can be used to prevent the degenerative processes and inflammation associated with ageing. Thus, the aim of the present study was to evaluate the effects of resistance training on cytokines, leptin, resistin, and muscle strength in post-menopausal women. Thirty-five sedentary women (mean age 63.18 years, s = 4.8; height 1.64 m, s = 0.07; body mass 57.84 kg, s = 7.70) were recruited. The 16 weeks of periodized resistance training consisted of two weekly sessions of three sets of 6-14 repetition maximum. Maximal strength was tested in bench press, 45 degrees leg press, and arm curl. Plasma tumour necrosis factor-alpha, interleukin-6, interleukin-15, leptin, and resistin were determined by enzyme-linked immunosorbent assay. Maximal strength on all measures was increased after 16 weeks. There were minor or no modifications in tumour necrosis factor-alpha and interleukin-15. Interleukin-6 was decreased 48 h after compared with baseline and declined after 16 weeks. Leptin decreased 24 h after compared with baseline and was reduced at baseline and 48 h after compared with pre-training. There was a decrease in resistin after 24 and 48 h compared with baseline and a decline in baseline and immediately after levels compared with pre-training. A possible explanation of the results of the present study is a lower production of pro-inflammatory cytokines by the innate immune system. Periodized resistance training seems to be an important intervention to reduce systemic inflammation in this population.
authors.affiliation: Physiological Sciences, Federal University of Sao Carlos, Sao Carlos.
authors.forename: Jonato
authors.initials: J
authors.lastname: Prestes
authors.forename: Gilberto
authors.initials: G
authors.lastname: Shiguemoto
authors.forename: Joao Paulo
authors.initials: JP
authors.lastname: Botero
authors.forename: Anelena
authors.initials: A
authors.lastname: Frollini
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Dias
authors.forename: Richard
authors.initials: R
authors.lastname: Leite
authors.forename: Guilherme
authors.initials: G
authors.lastname: Pereira
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Magosso
authors.forename: Vilmar
authors.initials: V
authors.lastname: Baldissera
authors.forename: Claudia
authors.initials: C
authors.lastname: Cavaglieri
authors.forename: Sergio
authors.initials: S
authors.lastname: Perez
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D019409:Interleukin-15 / Q000097:blood; D015848:Interleukin-5 / Q000097:blood; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000502:physiology; D017698:Postmenopause / Q000502:physiology*; D055070:Resistance Training; D052243:Resistin / Q000097:blood*; D057185:Sedentary Behavior; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D016207:Cytokines; D019409:Interleukin-15; D015848:Interleukin-5; D020738:Leptin; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha