Treatment of resistant obsessive-compulsive disorder with ventral capsular/ventral striatal gamma capsulotomy: a pilot prospective study.
A subgroup of obsessive-compulsive disorder (OCD) patients remains refractory to conventional treatments. For them, a new stereotactic radiosurgery has been recently developed: the ventral capsular/ventral striatal (VC/VS) gamma capsulotomy. The authors aim to report efficacy and adverse events of VC/VS gamma capsulotomy. Five refractory OCD patients were selected. The authors assessed OCD, anxiety and depressive symptoms, and side effects pre- and postoperatively. Three patients (60%) met response criteria 48 months after surgery. Adverse effects were episodic and transient. Ventral capsular/ventral striatal gamma capsulotomy holds therapeutic promise, with few adverse effects.
Lopes
Antonio Carlos
AC
Obsessive Compulsive Spectrum Disorders Program (PROTOC), Department of Psychiatry, University of São Paulo School of Medicine, R. Dr. Ovídio Pires de Campos, 785, 3 degrees andar, sala 9, São Paulo, SP 01060-970, Brazil. antonioclopesmd@gmail.com
Greenberg
Benjamin D
BD
Norén
Georg
G
Canteras
Miguel Montes
MM
Busatto
Geraldo F
GF
de Mathis
Maria Eugênia
ME
Taub
Anita
A
D'Alcante
Carina Chaubet
CC
Hoexter
Marcelo Queiroz
MQ
Gouvea
Fernando Sauerbronn
FS
Cecconi
Janaína Philippi
JP
Gentil
André F
AF
Ferrão
Ygor Arzeno
YA
Fuentes
Daniel
D
de Castro
Cláudio Campi
CC
Leite
Cláudia C
CC
Salvajoli
João Victor
JV
Duran
Fábio L S
FL
Rasmussen
Steven
S
Miguel
Eurípedes Constantino
EC
D000328:Adult; D001479:Basal Ganglia / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D020772:Internal Capsule / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000601:surgery*; D010865:Pilot Projects; D011446:Prospective Studies; D016634:Radiosurgery; D016896:Treatment Outcome