title: Staphylococcus aureus Panton-Valentine leukocidin targets muscle tissues in a child with myositis and necrotizing fasciitis.
abstract: The incidence of myositis has been increasing since the advent of the epidemic of community-associated methicillin-resistant Staphylococcus aureus infection, and Panton-Valentine leukocidin has been implicated as a factor contributing to more-severe muscle injury. We report a case of severe myositis accompanying septic osteomyelitis and necrotizing fasciitis caused by a Panton-Valentine leukocidin-positive S. aureus strain. Immunostaining showed strong binding of the Panton-Valentine leukocidin toxin to necrotic muscle tissues.
authors.affiliation: Division of Pediatric Infectious Diseases, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
authors.forename: Deborah
authors.initials: D
authors.lastname: Lehman
authors.forename: Ching Wen
authors.initials: CW
authors.lastname: Tseng
authors.forename: Samantha
authors.initials: S
authors.lastname: Eells
authors.forename: Loren G
authors.initials: LG
authors.lastname: Miller
authors.forename: Xuemo
authors.initials: X
authors.lastname: Fan
authors.forename: David O
authors.initials: DO
authors.lastname: Beenhouwer
authors.forename: George Y
authors.initials: GY
authors.lastname: Liu
mesh_terms: D001427:Bacterial Toxins / Q000378:metabolism*; D002648:Child; D005098:Exotoxins / Q000378:metabolism*; D019115:Fasciitis, Necrotizing / Q000188:drug therapy / Q000382:microbiology*; D006651:Histocytochemistry; D006801:Humans; D007956:Leukocidins / Q000378:metabolism*; D008297:Male; D009220:Myositis / Q000188:drug therapy / Q000382:microbiology*; D016133:Polymerase Chain Reaction; D011859:Radiography; D012782:Shoulder / Q000000981:diagnostic imaging / Q000382:microbiology; D013211:Staphylococcus aureus / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*
chemical_list: D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin