Quantitative determination and localization of cathepsin D and its inhibitors.
A literature survey was performed of the methods of quantitative assessment of the activity and concentration of cathepsin D and its inhibitors. Usefulness of non-modified and modified proteins and synthetic peptides as measurement substrates was evaluated. The survey includes also chemical and immunochemical methods used to determine the distribution of cathepsin D and its inhibitors in cells and tissues.
Minarowska
Alina
A
Department of Clinical Nursing, Medical University of Bialystok, Bialystok, Poland. minar@mp.pl
Karwowska
Alicja
A
Gacko
Marek
M
D000595:Amino Acid Sequence; D000818:Animals; D002402:Cathepsin D / Q000032:analysis* / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000032:analysis*; D007120:Immunochemistry; D008969:Molecular Sequence Data; D013154:Spleen / Q000201:enzymology; D013552:Swine
D004791:Enzyme Inhibitors; D002402:Cathepsin D