Thymic squamous cell carcinoma producing granulocyte colony-stimulating factor associated with a high serum level of interleukin 6.
Granulocyte colony-stimulating factor (G-CSF)-producing thymic carcinoma is extremely rare. A-66-year-old man presented with an anterior mediastinal mass, and underwent surgical biopsy. He had marked leukocytosis, and his serum levels of G-CSF and interleukin-6 were elevated. Histologically, the tumor consisted of squamous cell carcinoma, which showed positive immunoreactivity for G-CSF. He was treated with thoracic radiotherapy, and chest imaging revealed a marked reduction of tumor size. He was doing well at 8 months after tumor diagnosis.
Ayabe
Eriko
E
Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho, Shizuoka 411-8777, Japan.
Kaira
Kyoichi
K
Takahashi
Toshiaki
T
Murakami
Haruyasu
H
Tsuya
Asuka
A
Nakamura
Yukiko
Y
Naito
Tateaki
T
Endo
Masahiro
M
Yamamoto
Nobuyuki
N
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000175:diagnosis / Q000378:metabolism*; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D013953:Thymus Neoplasms / Q000097:blood / Q000175:diagnosis / Q000378:metabolism*
D015850:Interleukin-6; D016179:Granulocyte Colony-Stimulating Factor