title: Spectrum of CD30+ lymphoid proliferations in the eyelid lymphomatoid papulosis, cutaneous anaplastic large cell lymphoma, and anaplastic large cell lymphoma.
abstract: OBJECTIVE
  To report the clinicopathologic features of 3 patients with CD30(+) lymphoid proliferations of the eyelid.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  Patients with cutaneous CD30(+) lymphoproliferative lesions of the eyelid.
  
  
  METHODS
  Three patients with CD30(+) non-mycosis fungoides T-cell lymphoid infiltrates of the eyelid were identified. The histories, clinical findings, pathologic features including immunohistochemical staining, treatments, and outcomes were reviewed and compared.
  
  
  METHODS
  Pathologic findings including immunohistochemical analysis.
  
  
  RESULTS
  The patients included an 81-year-old man, an 18-year-old man, and a 42-year-old woman with CD30(+) lymphoid proliferations of the eyelid and adjacent soft tissue. The first patient had an isolated crateriform eyelid lesion that was classified as lymphomatoid papulosis (LyP). The second patient had an isolated multinodular lesion of the eyelid that was classified as cutaneous anaplastic large cell lymphoma (cALCL). The third patient presented with eyelid edema with an underlying mass and was found to have widely disseminated anaplastic large cell lymphoma (ALCL). Diagnoses were dependent on clinical findings.
  
  
  CONCLUSIONS
  The CD30(+) lymphoid proliferations represent a spectrum of conditions ranging from indolent LyP, to moderately aggressive cALCL, to highly aggressive ALCL. Interpretation of the pathologic findings in CD30(+) lymphoid proliferations is based in part on clinical findings.
  
  
  BACKGROUND
  The authors have no proprietary or commercial interest in any material discussed in this article.
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
authors.forename: R Krishna
authors.initials: RK
authors.lastname: Sanka
authors.forename: Ralph C
authors.initials: RC
authors.lastname: Eagle
authors.forename: Ted H
authors.initials: TH
authors.lastname: Wojno
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Neufeld
authors.forename: Hans E
authors.initials: HE
authors.lastname: Grossniklaus
mesh_terms: D000293:Adolescent; D000328:Adult; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D005142:Eyelid Neoplasms / Q000737:chemistry / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis; D017728:Lymphoma, Large-Cell, Anaplastic / Q000737:chemistry / Q000473:pathology*; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000737:chemistry / Q000473:pathology*; D017731:Lymphomatoid Papulosis / Q000378:metabolism / Q000473:pathology*; D008297:Male; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D017730:Ki-1 Antigen