title: [Severe systemic lupus erythematosus induced by isoniazide].
abstract: The authors report a rare case of low register systemic lupus erythematosus with renal attack and neurological armature by isoniazid. The patient was a 23-year-old woman presenting a lupus induced by isoniazid 1 month after the treatment of pleural tuberculosis. Antinuclear antibodies, anti-native DNA, anti-ENA, anti-Sm, anti-SSa, anti-SSb and antihistone were present. The symptoms included arthralgia, fever, anaemia, pleural effusion, pericarditis and anasarca. She presented a renal and neurological attack, accounting for the gravity of the disease. The treatment consisted of the interruption of the isoniazid and a bolus of methyl-prednisolone during 3 days relayed by an oral corticosteroid. The evolution was favourable after 8 months of corticosteroids.
authors.affiliation: Unité de soins, de formations et de recherches de pneumologie, CHU d'Antananarivo, Antananarivo, Madagascar. jrakotoson@yahoo.fr
authors.forename: J L
authors.initials: JL
authors.lastname: Rakotoson
authors.forename: D
authors.initials: D
authors.lastname: Randriamanana
authors.forename: J R
authors.initials: JR
authors.lastname: Rakotomizao
authors.forename: R
authors.initials: R
authors.lastname: Andrianasolo
authors.forename: R
authors.initials: R
authors.lastname: Rakotoarivelo
authors.forename: A C F
authors.initials: AC
authors.lastname: Andrianarisoa
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000097:blood; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects* / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D008181:Lupus Nephritis / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy; D008270:Madagascar; D008775:Methylprednisolone / Q000627:therapeutic use; D014396:Tuberculosis, Pleural / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D000974:Antibodies, Antinuclear; D000995:Antitubercular Agents; D007538:Isoniazid; D008775:Methylprednisolone