Bioactive sesquiterpenes isolated from the essential oil of Dalbergia odorifera T. Chen.
Investigation of the essential oil from the heartwood of Dalbergia odorifera T. Chen afforded the sesquiterpenes 1 and 2, that both showed anti-platelet activity. Their backbones were totally the same only with subtle difference in the chiral centre. Additionally, antithrombotic and anti-platelet activities of these two compounds were measured. The results showed that the antithrombotic activity of these two compounds was poor, while their anti-platelet activity was strong at middle and high concentrations.
Tao
Yi
Y
Institute of Pharmaceutical Informatics, Zhejiang University, Zijingang, Hangzhou, PR China.
Wang
Yi
Y
D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000991:Antithrombins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D035782:Dalbergia / Q000737:chemistry*; D008297:Male; D015394:Molecular Structure; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014934:Wood
D000925:Anticoagulants; D000991:Antithrombins; D009822:Oils, Volatile; D010936:Plant Extracts; D012717:Sesquiterpenes