Mononuclear phagocytes in head and neck squamous cell carcinoma.
The head and neck squamous cell carcinoma microenvironments contain many immune cells and their secretory products. Many of these cells belong to the mononuclear phagocyte system. The aim of this review is to study the interactions between mononuclear phagocytes and head and neck squamous cell carcinoma tissue. The role of inflammation in tumours and the cytokine interleukin-6 will be highlighted. Future therapy strategies in the treatment of head and neck cancer might be directed towards mononuclear phagocytes and their cytokine production.
Kross
Kenneth Wilfried
KW
Department of Otolaryngology, Head and Neck Surgery, Maastricht University Medical Centre, PP Box 5800, 6202 AZ, Maastricht, The Netherlands. kenneth.kross@mumc.nl
Heimdal
John-Helge
JH
Aarstad
Hans Jørgen
HJ
D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D018836:Inflammation Mediators / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D009000:Monocytes / Q000276:immunology / Q000473:pathology; D012157:Mononuclear Phagocyte System / Q000276:immunology* / Q000473:pathology; D009367:Neoplasm Staging; D010039:Otorhinolaryngologic Neoplasms / Q000276:immunology* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D010587:Phagocytosis / Q000276:immunology; D010844:Picibanil / Q000627:therapeutic use; D011379:Prognosis; D047368:Tumor Burden
D000970:Antineoplastic Agents; D016207:Cytokines; D018836:Inflammation Mediators; D015850:Interleukin-6; D010844:Picibanil