Lymphocytic infundibuloneurohypophysitis: long-term follow-up of a case cured with glucocorticoid.
OBJECTIVE
To report a case of infundibuloneurohypophysitis treated with steroid.


METHODS
A 65-year-old woman who was well until 4 weeks before admission and was not taking any medication presented with acute development of polydipsia and polyuria. Urinary volume was increased to 4,500 ml/day. She showed elevated serum osmolality and low urine osmolality, together with shortage of antidiuretic hormone. Magnetic resonance imaging (MRI) of the pituitary revealed marked nodular thickening of the neurohypophysis. Endocrinologically, anterior pituitary function appeared normal. Based on these examinations, she was diagnosed as having central diabetes insipidus due to lymphocytic infundibuloneurohypophysitis.


METHODS
Prednisolone (1 mg/kg/day, p.o.) and D-deaminovasopressin (5 microg/day, intranasal) were commenced. Ten days after the administration of the agents, MRI showed a dramatic improvement in the thickening of the neurohypophysis. Ten weeks later, abnormalities found in earlier MRI had disappeared. The drugs were withdrawn gradually, and diabetes insipidus ceased 25 weeks later. Recurrence was not seen in the subsequent MRI, and the function of the posterior pituitary gland was completely normalized even 7 years after discontinuation of treatments.


CONCLUSIONS
This case shows that noninvasive diagnosis and appropriate steroid administration can effectively cure lymphocytic infundibuloneurohypophysitis; it is recommended with long-term follow-up.
Inaba
Hidefumi
H
Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine, Matsumoto, Japan. dinaba@shinshu-u.ac.jp
Suzuki
Satoru
S
Shigematsu
Satoshi
S
Takei
Masahiro
M
Miyamoto
Takahide
T
Takeda
Teiji
T
Yamauchi
Keishi
K
Hashizume
Kiyoshi
K
D000368:Aged; D000932:Antiemetics / Q000627:therapeutic use; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D020790:Diabetes Insipidus, Neurogenic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D010902:Pituitary Gland / Q000473:pathology*; D011239:Prednisolone / Q000627:therapeutic use*; D013256:Steroids / Q000627:therapeutic use*
D000932:Antiemetics; D013256:Steroids; D011239:Prednisolone; D003894:Deamino Arginine Vasopressin