Changes in metabolic parameters following a switch to aripiprazole in Japanese patients with schizophrenia: One-year follow-up study.
The purpose of the present study was to evaluate changes in metabolic parameters after switching to aripiprazole in Japanese population. In this 1-year observation study, following a switch to aripiprazole, 32 patients with schizophrenia were observed and assessment was done of bodyweight, total cholesterol, triglyceride, serum prolactin level, and corrected QT (QTc) interval. Significant reductions were observed in these parameters other than QTc interval. Given known detrimental metabolic and hormonal effects of some atypical antipsychotics, a switch to aripiprazole may warrant serious consideration also in Asian patients who suffer those side-effects.
Takeuchi
Hiroyoshi
H
Department of Neuropsychiatry, Keio University, School of Medicine, Tokyo, Japan.
Uchida
Hiroyuki
H
Suzuki
Takefumi
T
Watanabe
Koichiro
K
Kashima
Haruo
H
D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000068180:Aripiprazole; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000187:drug effects; D006728:Hormones / Q000097:blood; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000009:adverse effects / Q000627:therapeutic use*; D011388:Prolactin / Q000097:blood; D015363:Quinolones / Q000009:adverse effects / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy* / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
D014150:Antipsychotic Agents; D006728:Hormones; D010879:Piperazines; D015363:Quinolones; D014280:Triglycerides; D000068180:Aripiprazole; D011388:Prolactin; D002784:Cholesterol