The novel function of nesfatin-1: anti-hyperglycemia.
Nesfatin-1 is recently reported as a satiety molecule to suppress food intake via the melanocortin signaling in hypothalamus when injected centrally and peripherally. Here we report that nesfatin-1 is also anti-hyperglycemic. It was found that the intravenous injection of nesfatin-1 significantly reduced blood glucose in hyperglycemic db/db mice. This anti-hyperglycemic effect of nesfatin-1 was time-, dose-, insulin-dependent and peripheral.
Su
Yijing
Y
Institute of Molecular & Experimental Therapeutics, East China Normal University, Shanghai 200062, China.
Zhang
Jing
J
Tang
Yanchun
Y
Bi
Feng
F
Liu
Jian-Ning
JN
D000813:Anilides / Q000494:pharmacology; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects*; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D004435:Eating / Q000187:drug effects; D006943:Hyperglycemia / Q000378:metabolism*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D051379:Mice; D008817:Mice, Mutant Strains; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins; D036361:Peptide Hormones / Q000096:biosynthesis / Q000235:genetics / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D054411:Receptors, Leptin / Q000235:genetics; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology
C457499:2-chloro-5-nitrobenzanilide; D000813:Anilides; D001067:Appetite Depressants; D001786:Blood Glucose; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D000960:Hypolipidemic Agents; D007328:Insulin; D009419:Nerve Tissue Proteins; C000630651:Nucb1 protein, mouse; D000080866:Nucleobindins; D036361:Peptide Hormones; D011720:Pyrazoles; D011743:Pyrimidines; D054411:Receptors, Leptin; D045162:Thiazolidinediones; C515447:leptin receptor, mouse; D000077154:Rosiglitazone; C516138:dorsomorphin