title: Structural and functional role of Staphylococcus aureus surface components recognizing adhesive matrix molecules of the host.
abstract: Staphylococcus aureus is a versatile and harmful human pathogen in both hospital- and community-acquired infections. S. aureus can initiate host infection by adhering to components of the extracellular matrix. Adherence is mediated by a variety of protein adhesins of the microbial surface component recognizing adhesive matrix molecule (MSCRAMM) family. In this article, we describe these MSCRAMMs in terms of structural organization and ligand-binding capacity and discuss their role as a possible target for immunotherapy.
authors.affiliation: Department of Biochemistry, 27100 Pavia, Italy. pspeziale@unipv.it
authors.forename: Pietro
authors.initials: P
authors.lastname: Speziale
authors.forename: Giampiero
authors.initials: G
authors.lastname: Pietrocola
authors.forename: Simonetta
authors.initials: S
authors.lastname: Rindi
authors.forename: Maria
authors.initials: M
authors.lastname: Provenzano
authors.forename: Giulio
authors.initials: G
authors.lastname: Provenza
authors.forename: Antonella
authors.initials: A
authors.lastname: Di Poto
authors.forename: Livia
authors.initials: L
authors.lastname: Visai
authors.forename: Carla Renata
authors.initials: CR
authors.lastname: Arciola
mesh_terms: D018829:Adhesins, Bacterial / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D001422:Bacterial Adhesion; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D011485:Protein Binding; D020836:Protein Structure, Quaternary; D017434:Protein Structure, Tertiary; D013211:Staphylococcus aureus / Q000502:physiology*
chemical_list: D018829:Adhesins, Bacterial; D016326:Extracellular Matrix Proteins; C509820:MSCRAMM proteins, Staphylococcus