title: Nuclear factor-kappa B inhibition reduces markedly cell proliferation in Epstein-Barr virus-infected stomach cancer, but affects variably in Epstein-Barr virus-negative stomach cancer.
abstract: Nuclear factor-kappa B (NF-kappaB) inhibition by NF-kappaB p65-specific siRNA induced a near-cessation of cell proliferation in EBV-positive stomach cancer cell, and notably diminished cell proliferation in EBV- positive Raji lymphoma cell. In EBV-negative stomach cancer cells, NF-kappaB inhibition affected variably cell proliferation. Regardless of cell type, NF-kappaB inhibition suppressed antiapoptotic function of NF-kappaB, and tended to promote the nuclear accumulation of beta-catenin. This inverse relationship between NF-kappaB and beta-catenin was evident in 120 resected gastric carcinomas. Conclusively, NF-kappaB inhibition may be beneficial in the therapy of EBV-positive stomach cancer, but influence variously EBV-negative stomach cancer.
authors.affiliation: Center for Antimicrobial Resistance and Microbial Genetics, Department of Infectious Diseases, University of Ulsan College of Medicine, Seoul 138-736, Korea.
authors.forename: Jin-Yong
authors.initials: JY
authors.lastname: Jeong
authors.forename: Jun Hee
authors.initials: JH
authors.lastname: Woo
authors.forename: Yang Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Sangho
authors.initials: S
authors.lastname: Choi
authors.forename: Sang Oh
authors.initials: SO
authors.lastname: Lee
authors.forename: Seol-Ryoung
authors.initials: SR
authors.lastname: Kil
authors.forename: Chul Woo
authors.initials: CW
authors.lastname: Kim
authors.forename: Byung Lan
authors.initials: BL
authors.lastname: Lee
authors.forename: Woo Ho
authors.initials: WH
authors.lastname: Kim
authors.forename: Byung-Ho
authors.initials: BH
authors.lastname: Nam
authors.forename: Mee Soo
authors.initials: MS
authors.lastname: Chang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004854:Herpesvirus 4, Human; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D013274:Stomach Neoplasms / Q000821:virology; D014162:Transfection; D051176:beta Catenin / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D051176:beta Catenin