Highly functionalized daphnane diterpenoids from Trigonostemon thyrsoideum.
Trigonothyrins A-C (1-3), which are highly functionalized daphnane diterpenoids, were isolated from the stems of Trigonostemon thyrsoideum. Compounds 1-3 represent the first examples of daphnanes with an oxygen-bridged four-membered-ring system, and a linkage mode of 12,13,14-orthoester. Compound 3 was observed to inhibit HIV-1 induced cytopathic effects. The EC(50) value was 2.19 microg/mL, and the therapeutic index (TI) was more than 90.
Zhang
Ling
L
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Luo
Rong-Hua
RH
Wang
Fei
F
Jiang
Meng-Yuan
MY
Dong
Ze-Jun
ZJ
Yang
Liu-Meng
LM
Zheng
Yong-Tang
YT
Liu
Ji-Kai
JK
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D004224:Diterpenes; C547176:trigonothyrin A; C547177:trigonothyrin B; C547178:trigonothyrin C