title: An organism arises from every nucleus.
abstract: The fact that, cloning using somatic cell nuclear transfer (SCNT) method has been performed, opened new horizons for cloning, and changed the way of our understanding and approach to cell and nucleus. The progress in cloning technology, brought the anticipation of the ability to clone an organism from each somatic cell nucleus. Therefore, the 'Cell Theory' is about to take the additional statement as "An organism arises from every nucleus". The development of gene targeting procedures which can be applied with SCNT, showed us that it may be possible to obtain different versions of the original genetic constitution of a cell. Because of this opportunity which is provided by SCNT, in reproductive cloning, it would be possible to clone enhanced organisms which can adapt to different environmental conditions and survive. Furthermore, regaining the genetic characteristics of ancestors or reverse herediter variations would be possible. On the other hand, in therapeutic cloning, more precise and easily obtainable alternatives for cell replacement therapy could be presented. However, while producing healthier or different organisms from a nucleus, it is hard to foresee the side effects influencing natural processes in long term is rather difficult.
authors.affiliation: Faculty of Dentistry, Department of Histology and Embryology, Istanbul University, Istanbul, Turkey. nkeklik@istanbul.edu.tr
authors.forename: Nurullah
authors.initials: N
authors.lastname: Keklikoglu
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics; D019976:Cloning, Organism; D053652:Nuclear Transfer Techniques