title: The cerebellar microcircuit as an adaptive filter: experimental and computational evidence.
abstract: Initial investigations of the cerebellar microcircuit inspired the Marr-Albus theoretical framework of cerebellar function. We review recent developments in the experimental understanding of cerebellar microcircuit characteristics and in the computational analysis of Marr-Albus models. We conclude that many Marr-Albus models are in effect adaptive filters, and that evidence for symmetrical long-term potentiation and long-term depression, interneuron plasticity, silent parallel fibre synapses and recurrent mossy fibre connectivity is strikingly congruent with predictions from adaptive-filter models of cerebellar function. This congruence suggests that insights from adaptive-filter theory might help to address outstanding issues of cerebellar function, including both microcircuit processing and extra-cerebellar connectivity.
authors.affiliation: Department of Psychology, University of Sheffield, Western Bank, Sheffield, S10 2TP, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Dean
authors.forename: John
authors.initials: J
authors.lastname: Porrill
authors.forename: Carl-Fredrik
authors.initials: CF
authors.lastname: Ekerot
authors.forename: Henrik
authors.initials: H
authors.lastname: Jörntell
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D013569:Synapses / Q000502:physiology