title: Efficacy of transsphenoidal surgery on endocrinological status and serum chemistry parameters in dogs with Cushing's disease.
abstract: Postoperative changes in endocrinological status and serum chemistry during the 4 years after transsphenoidal surgery (TSS) in 25 dogs with Cushing's disease were investigated in a prospective study. In all 25 dogs, Cushing's disease was diagnosed from resected pituitary tissues as a corticotroph adenoma in the anterior lobe of the pituitary. Prior to TSS, all 25 dogs showed hypercortisolemia. After TSS, the ACTH stimulation test showed continued low serum cortisol concentrations in 21 dogs (84%). In addition, the serum thyroid stimulating hormone concentrations decreased sequentially, while the serum T4 concentrations tended to increase due to the postoperative hormone substitution therapy utilized to avoid secondary hypothyroidism. In regard to serum chemistry, alkaline phosphatase (ALP), alanine aminotransferase (ALT) and total cholesterol are commonly increased in canine Cushing's disease. In this study, ALP, ALT and total cholesterol were increased in 23 cases (92%), 19 cases (76%) and 20 cases (80%), respectively. However, postoperatively, these concentrations gradually decreased. The postoperative serum concentrations of ALP at 1 year, that of ALT at six months to 2 years and that of total cholesterol over the course of the 4 years decreased significantly compared with the concentrations before TSS. These results show that TSS is an effective treatment for canine Cushing's disease and for long-term improvement of hypercortisolemia. Moreover, TSS is effective in improvement of hypercortisolism, such as increased concentrations of serum ALP, ALT and total cholesterol.
authors.affiliation: Division of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo. hara@nvlu.ac.jp
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Hara
authors.forename: Takahiro
authors.initials: T
authors.lastname: Teshima
authors.forename: Takahiro
authors.initials: T
authors.lastname: Taoda
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Ishino
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nezu
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Harada
authors.forename: Takuya
authors.initials: T
authors.lastname: Yogo
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Masuda
authors.forename: Akira
authors.initials: A
authors.lastname: Teramoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tagawa
mesh_terms: D000236:Adenoma / Q000601:surgery / Q000662:veterinary; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004283:Dog Diseases / Q000097:blood / Q000401:mortality / Q000601:surgery*; D004285:Dogs; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D009919:Orchiectomy / Q000662:veterinary; D010052:Ovariectomy / Q000662:veterinary; D047748:Pituitary ACTH Hypersecretion / Q000097:blood / Q000401:mortality / Q000601:surgery / Q000662:veterinary*; D010900:Pituitary Diseases / Q000473:pathology / Q000601:surgery / Q000662:veterinary; D011184:Postoperative Period; D013100:Sphenoid Bone / Q000601:surgery; D015996:Survival Rate
chemical_list: D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D006854:Hydrocortisone