XBP1: the last two decades.
The transcription factor X box-binding protein 1 (XBP1) was isolated two decades ago in a search for regulators of major histocompatibility complex (MHC) class II gene expression. Many years of research finally revealed a protein with many functions, none of them related to the MHC. This paper provided an overview of what this multifunctional transcription factor actually does.
Glimcher
L H
LH
Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Avenue, FXB 205, Boston, MA 02115, USA. lglimche@hsph.harvard.edu
D000818:Animals; D003424:Crohn Disease / Q000235:genetics; D004268:DNA-Binding Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D004751:Enteritis / Q000503:physiopathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007413:Intestinal Mucosa / Q000378:metabolism; D051379:Mice; D009154:Mutation; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D056811:Unfolded Protein Response / Q000502:physiology; D000071717:X-Box Binding Protein 1
D004268:DNA-Binding Proteins; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1; C000605543:XBP1 protein, human; C000605544:Xbp1 protein, mouse