title: Comparison of hemodynamics of intracranial aneurysms between MR fluid dynamics using 3D cine phase-contrast MRI and MR-based computational fluid dynamics.
abstract: BACKGROUND
  Hemodynamics is thought to play a very important role in the initiation, growth, and rupture of intracranial aneurysms. The purpose of our study was to compare hemodynamics of intracranial aneurysms of MR fluid dynamics (MRFD) using 3D cine PC MR imaging (4D-Flow) at 1.5 T and MR-based computational fluid dynamics (CFD).
  
  
  METHODS
  4D-Flow was performed for five intracranial aneurysms by a 1.5 T MR scanner. 3D TOF MR angiography was performed for geometric information. The blood flow in the aneurysms was modeled using CFD simulation based on the finite element method. We used MR angiographic data as the vascular models and MR flow information as boundary conditions in CFD. 3D velocity vector fields, 3D streamlines, shearing velocity maps, wall shear stress (WSS) distribution maps and oscillatory shear index (OSI) distribution maps were obtained by MRFD and CFD and were compared.
  
  
  RESULTS
  There was a moderate to high degree of correlation in 3D velocity vector fields and a low to moderate degree of correlation in WSS of aneurysms between MRFD and CFD using regression analysis. The patterns of 3D streamlines were similar between MRFD and CFD. The small and rotating shearing velocities and higher OSI were observed at the top of the spiral flow in the aneurysms. The pattern and location of shearing velocity in MRFD and CFD were similar. The location of high oscillatory shear index obtained by MRFD was near to that obtained by CFD.
  
  
  CONCLUSIONS
  MRFD and CFD of intracranial aneurysms correlated fairly well.
authors.affiliation: Department of Radiology, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan. hisoda@hama-med.ac.jp
authors.forename: Haruo
authors.initials: H
authors.lastname: Isoda
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Ohkura
authors.forename: Takashi
authors.initials: T
authors.lastname: Kosugi
authors.forename: Masaya
authors.initials: M
authors.lastname: Hirano
authors.forename: Marcus T
authors.initials: MT
authors.lastname: Alley
authors.forename: Roland
authors.initials: R
authors.lastname: Bammer
authors.forename: Norbert J
authors.initials: NJ
authors.lastname: Pelc
authors.forename: Hiroki
authors.initials: H
authors.lastname: Namba
authors.forename: Harumi
authors.initials: H
authors.lastname: Sakahara
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D002532:Intracranial Aneurysm / Q000175:diagnosis* / Q000503:physiopathology*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity