title: In vivo dynamic optical coherence elastography using a ring actuator.
abstract: We present a novel sample arm arrangement for dynamic optical coherence elastography based on excitation by a ring actuator. The actuator enables coincident excitation and imaging to be performed on a sample, facilitating in vivo operation. Sub-micrometer vibrations in the audio frequency range were coupled to samples that were imaged using optical coherence tomography. The resulting vibration amplitude and microstrain maps are presented for bilayer silicone phantoms and multiple skin sites on a human subject. Contrast based on the differing elastic properties is shown, notably between the epidermis and dermis. The results constitute the first demonstration of a practical means of performing in vivo dynamic optical coherence elastography on a human subject.
authors.affiliation: School of Electrical, Electronic and Computer Engineering, The University of Western Australia, Crawley, Western Australia, Australia. brendank@ee.uwa.edu.au
authors.forename: Brendan F
authors.initials: BF
authors.lastname: Kennedy
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Hillman
authors.forename: Robert A
authors.initials: RA
authors.lastname: McLaughlin
authors.forename: Bryden C
authors.initials: BC
authors.lastname: Quirk
authors.forename: David D
authors.initials: DD
authors.lastname: Sampson
mesh_terms: D000328:Adult; D000465:Algorithms; D054459:Elasticity Imaging Techniques / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007368:Interferometry / Q000379:methods; D008297:Male; D019047:Phantoms, Imaging; D012542:Scattering, Radiation; D012867:Skin / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*