New polyketides from the marine-derived fungus Phaeosphaeria spartinae.
The fungus Phaeosphaeria spartinae is an endophyte of the marine alga Ceramium sp. Investigation of this marine-derived fungus led to the isolation of the new natural products spartinol A (1), B (2), C (3) and D (4). The structures of these closely related compounds were established from extensive spectroscopic investigations. Compound 3 showed weak inhibition of human leukocyte elastase (HLE).
Elsebai
Mahmoud Fahmi
MF
Institute for Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany.
Kehraus
Stefan
S
Gütschow
Michael
M
König
Gabriele M
GM
D001203:Ascomycota / Q000737:chemistry* / Q000145:classification / Q000254:growth & development; D018533:Biomass; D003470:Culture Media; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D053491:Proteinase Inhibitory Proteins, Secretory / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D003470:Culture Media; D018942:Macrolides; D053491:Proteinase Inhibitory Proteins, Secretory