title: Adaptive improved element free Galerkin method for quasi- or multi-spectral bioluminescence tomography.
abstract: Bioluminescence tomography (BLT) has become a powerful tool for whole-body small animal imaging. In this contribution, an adaptive improved element free Galerkin method (IEFGM) is presented to perform a quantitative reconstruction of the internal light source using quasi- or multi-spectral information, which not only can avoid the time-consuming mesh generation but also can reduce the ill-posedness of BLT effectively. In the algorithm, the reconstruction can be largely enhanced by an adaptive technology based on a posteriori error estimation. Finally, the numerical and physical phantom experiment results show that the bioluminescent source can be recovered accurately.
authors.affiliation: Institute of Automation, Chinese Academy of Sciences, Beijing, China.
authors.forename: Chenghu
authors.initials: C
authors.lastname: Qin
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.forename: Jinchao
authors.initials: J
authors.lastname: Feng
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.forename: Junting
authors.initials: J
authors.lastname: Liu
authors.forename: Guorui
authors.initials: G
authors.lastname: Yan
authors.forename: Shouping
authors.initials: S
authors.lastname: Zhu
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
mesh_terms: D000465:Algorithms; D000818:Animals; D020342:Finite Element Analysis; D007091:Image Processing, Computer-Assisted; D049449:Luminescence; D015233:Models, Statistical; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D013050:Spectrometry, Fluorescence / Q000295:instrumentation* / Q000379:methods; D013997:Time Factors; D014054:Tomography / Q000379:methods*