title: Exceptional bone metastasis of basal cell carcinoma in Gorlin-Goltz syndrome.
abstract: BACKGROUND
  Basal cell carcinoma (BCC), the most prevalent form of cancer worldwide, is a malignant skin neoplasm. It is locally invasive, with an exceptional incidence of reported metastasis. It can also be part of the Gorlin-Goltz syndrome, an autosomal dominant genetic disorder with high penetrance and variable expressivity, which is principally characterized by cutaneous BCC, odontogenic keratocysts, palmar and/or plantar pits, and falx cerebri calcification.
  
  
  METHODS
  We report the exceptional clinical observation of a 54-year-old man presenting bone metastasis from BCC in Gorlin-Goltz syndrome.
  
  
  CONCLUSIONS
  Less than 300 cases of metastatic BCC have been reported in the literature. The present case is the second associated with Gorlin-Goltz syndrome.
authors.affiliation: Gérontopôle, Department of Geriatric Medicine, CHU Toulouse, Toulouse, France.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Lamon
authors.forename: Stephane
authors.initials: S
authors.lastname: Gerard
authors.forename: Nicolas
authors.initials: N
authors.lastname: Meyer
authors.forename: Benjamin
authors.initials: B
authors.lastname: Losfeld
authors.forename: Gabor
authors.initials: G
authors.lastname: Abellan van Kan
authors.forename: Laurent
authors.initials: L
authors.lastname: Balardy
authors.forename: Bruno
authors.initials: B
authors.lastname: Vellas
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D002280:Basal Cell Carcinoma / Q000000981:diagnostic imaging / Q000556:secondary*; D005489:Focal Dermal Hypoplasia / Q000235:genetics / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010146:Pain / Q000209:etiology; D000072079:Patched Receptors; D011859:Radiography; D011956:Receptors, Cell Surface / Q000235:genetics; D012878:Skin Neoplasms / Q000473:pathology*; D044465:White People
chemical_list: D000072079:Patched Receptors; D011956:Receptors, Cell Surface