[Antibiotic prophylaxis in breast surgery. Preliminary resuls of a multicenter randomized study on 1400 cases].
Breast surgery is classified among the procedures performed in clean surgery and is associated with a low incidence of wound infection (3-15%). The objective of this study was to evaluate the advantages antibiotic prophylaxis in patients undergoing breast surgery. A multicenter randomized controlled study was performed between January 2008 and November 2008. One thousand four hundred patients were enrolled in prospective randomized study; surgical wound infection was found in 41 patients (2.93%). In our RCT we have shown that in breast surgery antibiotic prophylaxis does not present significant advantages in patients with potential risk of infection (17 patients, 2.42%, subjected to antibiotic prophylaxis vs 24 patients, 3.43%, without antibiotic prophylaxis) (P = 0.27). In patients with drainage there is a significant minor incidence of wound infections in patients receiving antibiotic prophylaxis (5 patients, 0.92%, subjected to antibiotic prophylaxis vs 14 patients, 3.09%, without antibiotic prophylaxis) (P = 0.02).


CONCLUSIONS
This study is only a preliminary RCT to be followed by a study which should be enrolled more patients in order to get the results as statistically significant.
Sanguinetti
Alessandro
A
SC Chirurgia Endocrina, Università degli Studi di Perugia. cirrocchiroberto@yahoo.it
Rosato
Lodovico
L
Cirocchi
Roberto
R
Barberini
Francesco
F
Pezzolla
Angela
A
Cavallaro
Giuseppe
G
Parmeggiani
Domenico
D
Ruggiero
Roberto
R
Docimo
Giovanni
G
Procaccini
Eugenio
E
Santoriello
Antonio
A
Rulli
Antonio
A
Gubitosi
Adelmo
A
Canonico
Silvestro
S
Taffurelli
Mario
M
Sciannameo
Francesco
F
Barbarisi
Alfonso
A
Docimo
Ludovico
L
Agresti
Massimo
M
De Toma
Giorgio
G
Noya
Giuseppe
G
Parmeggiani
Umberto
U
Avenia
Nicola
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001941:Breast Diseases / Q000601:surgery*; D001943:Breast Neoplasms / Q000601:surgery*; D002437:Cefazolin / Q000008:administration & dosage / Q000627:therapeutic use*; D019818:Clavulanic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D015409:Mastectomy, Radical; D015412:Mastectomy, Segmental; D008875:Middle Aged; D016017:Odds Ratio; D018579:Patient Selection; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000517:prevention & control*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D019818:Clavulanic Acid; D000658:Amoxicillin; D002437:Cefazolin