Adult-type granulosa cell tumors and FOXL2 mutation.
Little is known about the pathogenesis of ovarian granulosa cell tumors. Recently, we reported the identification of a somatic FOXL2 402C-->G mutation that is present in virtually all adult-type granulosa cell tumors, but not in a wide range of other tumor types. This finding has important implications for the diagnosis and classification of ovarian sex cord-stromal tumors, provides insight into the pathogenesis of adult-type granulosa cell tumors, and opens possibilities for the development of targeted therapies.
Köbel
Martin
M
Department of Pathology, University of Calgary, Canada.
Gilks
C Blake
CB
Huntsman
David G
DG
D000328:Adult; D005260:Female; D000074842:Forkhead Box Protein L2; D051858:Forkhead Transcription Factors / Q000235:genetics*; D006106:Granulosa Cell Tumor / Q000235:genetics*; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*
C421604:FOXL2 protein, human; D000074842:Forkhead Box Protein L2; D051858:Forkhead Transcription Factors