title: Drug-induced liver injury caused by the histrelin (Vantus) subcutaneous implant.
abstract: Drug-induced liver injury (DILI) is the leading cause of acute hepatic failure in the United States. Up to 13% of acute liver failure cases occur due to drugs other than acetaminophen. This clinical diagnosis, made after other causes of liver injury have been excluded, requires establishing a causal relationship between drug exposure and liver injury. The case of a patient with liver injury following a subcutaneous histrelin (Vantus) implant as therapy for advanced prostate cancer is presented.
authors.affiliation: Department of Gastroenterology, Wilford Hall Medical Center, Lackland AFB, TX, USA. doctorntraining2004@yahoo.com
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Ricker
authors.forename: William F
authors.initials: WF
authors.lastname: Foody
authors.forename: Nathan M
authors.initials: NM
authors.lastname: Shumway
authors.forename: Janet C
authors.initials: JC
authors.lastname: Shaw
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D004343:Drug Implants; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male
chemical_list: D018931:Antineoplastic Agents, Hormonal; D004343:Drug Implants; D007987:Gonadotropin-Releasing Hormone; C029256:histrelin