Adaptive improved element free Galerkin method for quasi- or multi-spectral bioluminescence tomography.
Bioluminescence tomography (BLT) has become a powerful tool for whole-body small animal imaging. In this contribution, an adaptive improved element free Galerkin method (IEFGM) is presented to perform a quantitative reconstruction of the internal light source using quasi- or multi-spectral information, which not only can avoid the time-consuming mesh generation but also can reduce the ill-posedness of BLT effectively. In the algorithm, the reconstruction can be largely enhanced by an adaptive technology based on a posteriori error estimation. Finally, the numerical and physical phantom experiment results show that the bioluminescent source can be recovered accurately.
Qin
Chenghu
C
Institute of Automation, Chinese Academy of Sciences, Beijing, China.
Yang
Xin
X
Feng
Jinchao
J
Liu
Kai
K
Liu
Junting
J
Yan
Guorui
G
Zhu
Shouping
S
Xu
Min
M
Tian
Jie
J
D000465:Algorithms; D000818:Animals; D020342:Finite Element Analysis; D007091:Image Processing, Computer-Assisted; D049449:Luminescence; D015233:Models, Statistical; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D013050:Spectrometry, Fluorescence / Q000295:instrumentation* / Q000379:methods; D013997:Time Factors; D014054:Tomography / Q000379:methods*