title: Influence of cytokine gene polymorphisms on prostate-specific antigen recurrence in prostate cancer after radical prostatectomy.
abstract: OBJECTIVE
  Evidence is accumulating indicating that chronic inflammation plays an important role in prostate cancer. We investigated the potential prognostic roles of IL-6, IL-8 and IL-10 polymorphisms in clinical localized prostate cancer after radical prostatectomy.
  
  
  METHODS
  A total of 116 clinically localized prostate cancer patients undergoing curative radical prostatectomy were included in this study. The IL-6, IL-8 and IL-10 polymorphisms were determined by the TaqMan real-time PCR method. Their prognostic significance on prostate-specific antigen (PSA) recurrence was assessed using Kaplan-Meier analysis and Cox regression model.
  
  
  RESULTS
  The IL-6 polymorphism (rs2066992) T/G and G/G genotype cases were associated with a higher percentage of preoperative PSA levels of > or =10 ng/ml; higher risk of positive surgical margin, and higher risk of extraprostatic extension compared to the T/T genotype. The IL-10 polymorphism (rs1800871) A/A genotype was associated with a higher risk of PSA recurrence compared with the A/G + G/G genotypes and significantly poorer PSA-free survival (log-rank test, p = 0.019). After considering other covariates in a Cox proportional hazard model, the IL-10A/A genotype and high Gleason score (8-10) were still independent predictors of poor PSA-free survival.
  
  
  CONCLUSIONS
  Our results suggest that the IL-10 polymorphism may be a prognostic factor for PSA recurrence after radical prostatectomy.
authors.affiliation: Department of Urology, Kaohsiung Medical University and Hospital, Kaohsiung, Taiwan.
authors.forename: Han-Ching
authors.initials: HC
authors.lastname: Lin
authors.forename: Chia-Chu
authors.initials: CC
authors.lastname: Liu
authors.forename: Wan-Yi
authors.initials: WY
authors.lastname: Kang
authors.forename: Chia-Cheng
authors.initials: CC
authors.lastname: Yu
authors.forename: Tony T
authors.initials: TT
authors.lastname: Wu
authors.forename: Jyh-Seng
authors.initials: JS
authors.lastname: Wang
authors.forename: Wen-Jeng
authors.initials: WJ
authors.lastname: Wu
authors.forename: Chun-Hsiung
authors.initials: CH
authors.lastname: Huang
authors.forename: Ming-Tsang
authors.initials: MT
authors.lastname: Wu
authors.forename: Shu-Pin
authors.initials: SP
authors.lastname: Huang
mesh_terms: D000368:Aged; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D016209:Interleukin-8 / Q000235:genetics*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000235:genetics* / Q000601:surgery
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8; D016753:Interleukin-10; D017430:Prostate-Specific Antigen