title: A preliminary controlled trial of cognitive behavioral therapy in clozapine-resistant schizophrenia.
abstract: The use of cognitive-behavior therapy (CBT) in addition to antipsychotic regimen to treat persistent psychotic symptoms of schizophrenia is growing. The aim of this study was to compare the efficacy of CBT to a befriending (BF) control group in patients with schizophrenia who are refractory to clozapine. Twenty-one patients completed the 21-week trial. In comparison with the control group, the CBT group showed a significant improvement in the General Psychopathology and total score of the Positive and Negative Syndrome Scale, as well as an improvement of Quality of Life scale. The improvement in psychopathology persisted at 6-month follow-up assessment.
authors.affiliation: Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo, SP-05403-010, Brazil.
authors.forename: Eliza Martha de Paiva
authors.initials: EM
authors.lastname: Barretto
authors.forename: Monica
authors.initials: M
authors.lastname: Kayo
authors.forename: Belquiz S
authors.initials: BS
authors.lastname: Avrichir
authors.forename: Antonio Reis
authors.initials: AR
authors.lastname: Sa
authors.forename: Maria das Gracas Miquelutti
authors.initials: Md
authors.lastname: Camargo
authors.forename: Isabel Cristina
authors.initials: IC
authors.lastname: Napolitano
authors.forename: Fabiano Gonçalves
authors.initials: FG
authors.lastname: Nery
authors.forename: Jony Arrais
authors.initials: JA
authors.lastname: Pinto
authors.forename: Silvia
authors.initials: S
authors.lastname: Bannwart
authors.forename: Silvia
authors.initials: S
authors.lastname: Scemes
authors.forename: Elaine
authors.initials: E
authors.lastname: Di Sarno
authors.forename: Helio
authors.initials: H
authors.lastname: Elkis
mesh_terms: D000328:Adult; D003024:Clozapine / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D004351:Drug Resistance; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D055815:Young Adult
chemical_list: D003024:Clozapine