title: High concentration of raltegravir in semen of HIV-infected men: results from a substudy of the EASIER-ANRS 138 trial.
abstract: Raltegravir concentrations and human immunodeficiency virus type 1 (HIV-1) RNA levels in semen samples from 10 treatment-experienced HIV-1-infected patients were measured after 24 weeks of raltegravir-based highly active antiretroviral therapy (HAART). Semen and plasma HIV-1 RNA levels were below 100 copies/ml and 50 copies/ml, respectively, in all samples. The median raltegravir concentrations in semen samples (n=10) and in plasma samples (n=9) drawn simultaneously were 345 (range, 83 to 707) ng/ml and 206 (range, 106 to 986) ng/ml, respectively. The median semen-to-plasma ratio of raltegravir concentration was 1.42 (range, 0.52 to 6.66), indicating good although variable levels of drug penetration of raltegravir in the seminal compartment.
authors.affiliation: Department of Clinical Pharmacy, Bicêtre Hospital, Assistance Publique Hôpitaux de Paris, 78 Rue du Général Leclerc, 94275 Le Kremlin Bicêtre, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Barau
authors.forename: Constance
authors.initials: C
authors.lastname: Delaugerre
authors.forename: Joséphine
authors.initials: J
authors.lastname: Braun
authors.forename: Nathalie
authors.initials: N
authors.lastname: de Castro
authors.forename: Valérie
authors.initials: V
authors.lastname: Furlan
authors.forename: Isabelle
authors.initials: I
authors.lastname: Charreau
authors.forename: Laurence
authors.initials: L
authors.lastname: Gérard
authors.forename: Caroline
authors.initials: C
authors.lastname: Lascoux-Combe
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Molina
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Taburet
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011760:Pyrrolidinones / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D000068898:Raltegravir Potassium; D012661:Semen / Q000378:metabolism*
chemical_list: D019380:Anti-HIV Agents; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium