title: Comparison of Surgisis, AlloDerm, and Vicryl Woven Mesh grafts for abdominal wall defect repair in an animal model.
abstract: BACKGROUND
  Surgisis and AlloDerm, two biosynthetic materials, have been previously used with success in abdominal wall repairs in the setting of contaminated fields. Historically, Vicryl Woven Mesh, a synthetic material, has also been used in such settings as a temporary bridge for abdominal wall reconstruction. This study compares Surgisis and AlloDerm with Vicryl Woven Mesh with respect to tensile strength, collagen remodeling, and neovascularization using a rat hernia model.
  
  
  METHODS
  A prospective randomized trial of 54 Sprague-Dawley rats were assigned to the Surgisis, AlloDerm, or Vicryl Woven Mesh group with baseline, 30-day, and 60-day end points. A 1.5-cm x 5.0-cm defect was created in the right abdominis rectus muscle and repaired with an underlay bridge graft using the different treatment materials. Tensile strength was measured using an Instron tensiometer. Histologic specimens were evaluated for neovascularization, collagen deposition, and collagen organization at the 30- and 60-day time points.
  
  
  RESULTS
  Surgisis had significantly greater tensile strength compared to Vicryl Woven Mesh at the baseline time point (0.142 vs. 0.091 MPa, p < 0.05). There were no differences between groups tensile strength at 30 or 60 days postoperatively. The Vicryl Woven Mesh and AlloDerm groups showed increases in tensile strength at 30 days postoperatively versus baseline (p < 0.05). Vicryl Woven Mesh, Surgisis, and AlloDerm all showed increases in tensile strength at 60 days postoperatively compared to 30 days postoperatively and at baseline (p < 0.05). Surgisis and AlloDerm had significantly greater (p < 0.05) amounts of collagen deposition and organization at 30 and 60 days compared to Vicryl Woven Mesh. There was no significant difference between AlloDerm and Surgisis with respect to collagen deposition and organization. Surgisis and AlloDerm showed a significantly greater amount (p < 0.05) of neovascularization than Vicryl Woven Mesh at both time points. In addition, Surgisis had a significantly greater amount (p < 0.05) of neovascularization than AlloDerm at both 30 and 60 days.
  
  
  CONCLUSIONS
  Surgisis has increased baseline tensile strength compared to Vicryl Woven Mesh. Tensile strength in Vicryl Woven Mesh is equal to biosynthetic grafts after tissue incorporation. Biosynthetic grafts showed superior collagen deposition and organization. Surgisis mesh showed increased neovascularization over both AlloDerm and Vicryl Woven Mesh.
authors.affiliation: Department of General Surgery, Dwight D. Eisenhower Army Medical Center, Fort Gordon, GA 30905, USA. s6rrice@yahoo.com
authors.forename: Robert D
authors.initials: RD
authors.lastname: Rice
authors.forename: Farhan S
authors.initials: FS
authors.lastname: Ayubi
authors.forename: Zachary J
authors.initials: ZJ
authors.lastname: Shaub
authors.forename: David M
authors.initials: DM
authors.lastname: Parker
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Armstrong
authors.forename: John W
authors.initials: JW
authors.lastname: Tsai
mesh_terms: D034861:Abdominal Wall / Q000473:pathology* / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials; D003094:Collagen / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008297:Male; D011098:Polyglactin 910 / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013526:Surgical Mesh; D013537:Sutures; D013718:Tensile Strength
chemical_list: C440568:Alloderm; D001672:Biocompatible Materials; D011098:Polyglactin 910; D003094:Collagen