Influence of cytokine gene polymorphisms on prostate-specific antigen recurrence in prostate cancer after radical prostatectomy.
OBJECTIVE
Evidence is accumulating indicating that chronic inflammation plays an important role in prostate cancer. We investigated the potential prognostic roles of IL-6, IL-8 and IL-10 polymorphisms in clinical localized prostate cancer after radical prostatectomy.


METHODS
A total of 116 clinically localized prostate cancer patients undergoing curative radical prostatectomy were included in this study. The IL-6, IL-8 and IL-10 polymorphisms were determined by the TaqMan real-time PCR method. Their prognostic significance on prostate-specific antigen (PSA) recurrence was assessed using Kaplan-Meier analysis and Cox regression model.


RESULTS
The IL-6 polymorphism (rs2066992) T/G and G/G genotype cases were associated with a higher percentage of preoperative PSA levels of > or =10 ng/ml; higher risk of positive surgical margin, and higher risk of extraprostatic extension compared to the T/T genotype. The IL-10 polymorphism (rs1800871) A/A genotype was associated with a higher risk of PSA recurrence compared with the A/G + G/G genotypes and significantly poorer PSA-free survival (log-rank test, p = 0.019). After considering other covariates in a Cox proportional hazard model, the IL-10A/A genotype and high Gleason score (8-10) were still independent predictors of poor PSA-free survival.


CONCLUSIONS
Our results suggest that the IL-10 polymorphism may be a prognostic factor for PSA recurrence after radical prostatectomy.
Lin
Han-Ching
HC
Department of Urology, Kaohsiung Medical University and Hospital, Kaohsiung, Taiwan.
Liu
Chia-Chu
CC
Kang
Wan-Yi
WY
Yu
Chia-Cheng
CC
Wu
Tony T
TT
Wang
Jyh-Seng
JS
Wu
Wen-Jeng
WJ
Huang
Chun-Hsiung
CH
Wu
Ming-Tsang
MT
Huang
Shu-Pin
SP
D000368:Aged; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D016209:Interleukin-8 / Q000235:genetics*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000235:genetics* / Q000601:surgery
D015850:Interleukin-6; D016209:Interleukin-8; D016753:Interleukin-10; D017430:Prostate-Specific Antigen