title: [Short-term efficacy evaluation of chronic pulmonary aspergillosis treated with micafangin and maintenance therapy of itraconazole].
abstract: We evaluated both the short-and long-term efficacy of micafungin in patients with chronic pulmonary aspergillosis (CPA). We treated 26 patients with CPA, 19 with chronic necrotizing pulmonary aspergillosis (CNPA) and 7 with aspergilloma, with micafungin between February 2003 and September 2005. On completion of treatment (short-term efficacy evaluation), the efficacy rates of micafungin for CNPA and aspergilloma were 52.6% (10/19) and 71.4% (5/7), respectively, and the overall efficacy rate was 57.7% (15/26). Long-term efficacy was evaluable in 25 of 26 patients, and 15 patients, who responded favorably to micafungin, received maintenance therapy with itraconazole (200mg). In long-term efficacy evaluation, 10 patients were unchanged, but in 5 patients symptoms were exacerbated after 1.8 months (median time). This result suggests that establishing effective maintenance therapy, as well as acute-phase therapy, is important in the treatment of patients with CPA.
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Nagara Medical Center.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Yasuda
authors.forename: Ryoko
authors.initials: R
authors.lastname: Ohnishi
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kimiyasu
authors.initials: K
authors.lastname: Sano
authors.forename: Tatuo
authors.initials: T
authors.lastname: Kato
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D054714:Echinocandins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D055666:Lipopeptides / Q000627:therapeutic use*; D008297:Male; D000077551:Micafungin; D008875:Middle Aged; D055732:Pulmonary Aspergillosis / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D017964:Itraconazole; D000077551:Micafungin