A 90-day intravenous administration toxicity study of CaO-SiO2-P2O5-B2O3 glass-ceramics (BGS-7) in rat.
CaO-SiO(2)-P(2)O(5)-B(2)O(3) glass ceramics directly bond to bone and have potential use as a bone substitute material. The present study evaluated the toxicity from subchronic intravenous administration of CaO-SiO(2)-P(2)O(5)-B(2)O(3) glass ceramics to male and female Sprague-Dawley rats. The rats were divided into four groups, each consisting of 10 male and 10 female rats, and administered different amounts of CaO-SiO(2)-P(2)O(5)-B(2)O(3) glass ceramics (aqueous extract 5, 2.5, and 1.25 mL/kg body weight/day and saline) 7 days per week for 90 consecutive days. During the experiment, no deaths were observed in any groups, and there were no remarkable changes in clinical signs, body weight, food and water intake, hematological and serum biochemical parameters, organ weight, and histopathological findings between the control and treated groups. The results show no adverse toxic effects of CaO-SiO(2)-P(2)O(5)-B(2)O(3) glass ceramics (aqueous extract 5 mL/kg body weight/day) to rats of either sex.
Lee
Jae Hyup
JH
Department of Orthopedic Surgery, College of Medicine and Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, SMG-SNUH Boramae Medical Center, Seoul, Korea. spinelee@snu.ac.kr
Ryu
Hyun-Seung
HS
Seo
Jun-Hyuk
JH
Chang
Bong-Soon
BS
Lee
Choon-Ki
CK
D000818:Animals; D018786:Bone Substitutes / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D001896:Boron Compounds / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D018675:Toxicity Tests
D018786:Bone Substitutes; D001896:Boron Compounds; C416205:calcium oxide-silicon dioxide-diphosphorus pentoxide glass; C042168:boron oxide