title: Polyacetylenes from Bupleurum longiradiatum.
abstract: Eight new polyacetylenes (1-8) and six known polyacetylenes were isolated from the entire parts of Bupleurum longiradiatum, a poisonous plant. The structures of the new compounds were determined by spectroscopic data interpretation. The absolute configuration of the known compound bupleurotoxin (9) was established by the modified Mosher's method. All isolates were also tested for their cytotoxicity against a human leukemia cell line (HL-60).
authors.affiliation: Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China.
authors.forename: Hai-Qiang
authors.initials: HQ
authors.lastname: Huang
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Juan
authors.initials: J
authors.lastname: Su
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Liu
authors.forename: Jun-Min
authors.initials: JM
authors.lastname: Tian
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Lei
authors.initials: L
authors.lastname: Shan
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000480:Alkynes; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029972:Bupleurum / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification; D053279:Polyynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000480:Alkynes; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D011090:Polyenes; C055767:bupleurotoxin; D053279:Polyynes