title: [Transesophageal endoscopic ultrasonography guided-fine needle aspiration for the diagnosis of sarcoidosis].
abstract: Sarcoidosis is a multi-organ disorder of unknown etiology characterized by noncaseating epithelioid cell granulomas. The specimen for histopathological diagnosis is usually obtained by transbronchial lung biopsy (TBLB), but the diagnostic accuracy rate of TBLB is not satisfactory, especially for stage I patients. Since hilar and mediastinal lymphadenopathy is a common finding in patients with sarcoidosis, an approach to lymph nodes is expected to have a good diagnosis yield. We present 3 sarcoidosis patients in whom specimens obtained by TBLB, transbronchial needle aspiration (TBNA) and transesophageal endoscopic ultrasonography guided-fine needle aspiration (EUS-FNA). The histopathological appearance of specimens obtained by EUS-FNA for swollen mediastinal lymph nodes showed noncaseating epithelioid granulomas which are characteristic of sarcoidosis in all 3 patients. On the other hand, no specific findings were recognized in the specimens obtained by TBLB and TBNA in 2 out of 3 patients. These results suggest that EUS-FNA is useful to obtain diagnostic specimens in cases of sarcoidosis.
authors.affiliation: Department of Pulmonary Medicine, School of Medicine, Fukushima Medical University.
authors.forename: Kazue
authors.initials: K
authors.lastname: Saito
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Tanino
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Inokoshi
authors.forename: Suguru
authors.initials: S
authors.lastname: Sato
authors.forename: Kengo
authors.initials: K
authors.lastname: Oshima
authors.forename: Taeko
authors.initials: T
authors.lastname: Ishii
authors.forename: Naoko
authors.initials: N
authors.lastname: Nakagawa
authors.forename: Atsuro
authors.initials: A
authors.lastname: Fukuhar
authors.forename: Kenya
authors.initials: K
authors.lastname: Kanazawa
authors.forename: Junpei
authors.initials: J
authors.lastname: Saito
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishida
authors.forename: Takuto
authors.initials: T
authors.lastname: Hikichi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Irisawa
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Ohira
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Munakata
mesh_terms: D000368:Aged; D044963:Biopsy, Fine-Needle / Q000379:methods*; D019160:Endosonography / Q000379:methods*; D004947:Esophagus; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000473:pathology*