title: Mydriasis associated with local dysfunction of parasympathetic nerves in two dogs.
abstract: In clinical practice, photophobia resulting from persistent mydriasis may be associated with dysfunction of ocular parasympathetic nerves or primary iris lesions. We encountered a 5-year-old Miniature Dachshund and a 7-year-old Shih Tzu with mydriasis, abnormal pupillary light reflexes, and photophobia. Except for sustained mydriasis and photophobia, no abnormalities were detected on general physical examination or ocular examination of either dog. We performed pharmacological examinations using 0.1% and 2% pilocarpine to evaluate and diagnose parasympathetic denervation of the affected pupillary sphincter muscles. On the basis of the results, we diagnosed a pupillary abnormality due to parasympathetic dysfunction and not to overt primary iris lesions. The test revealed that neuroanatomic localization of the lesion was postciliary ganglionic in the first dog.
authors.affiliation: Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, 4-101, Koyama-minami, Tottori 680-8553, Japan.
authors.forename: Teppei
authors.initials: T
authors.lastname: Kanda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tsuji
authors.forename: Keiko
authors.initials: K
authors.lastname: Hiyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsuka
authors.forename: Saburo
authors.initials: S
authors.lastname: Minami
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Hikasa
authors.forename: Toshinori
authors.initials: T
authors.lastname: Furukawa
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Okamoto
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D007249:Inflammation / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary; D008297:Male; D008540:Meiosis; D008916:Miotics / Q000627:therapeutic use; D015878:Mydriasis / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology / Q000662:veterinary*; D020795:Photophobia / Q000209:etiology / Q000662:veterinary; D010862:Pilocarpine / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D008916:Miotics; D010862:Pilocarpine; D011239:Prednisolone