[Correlation between neuroretinal rim area/retinal nerve fiber layer thickness and differential light sensitivity in visual field in primary open angle glaucoma].
OBJECTIVE
To explore the relationship between neuroretinal rim area (RA) /retinal nerve fiber layer (RNFL) thickness and differential light sensitivity (DLS) in visual field in primary open angle glaucoma (POAG).


METHODS
Fifty-one eyes of 51 patients with POAG were examined with HRT II, GDx VCC, and Octopus 101 for RA, RNFL thickness, and DLS. Their correlations were evaluated with linear and logarithmic regression models globally and for individual sectors.


RESULTS
In all the considered patients, visual field DLS was significantly correlated with neuroretinal RA or RNFL thickness globally and in individual sectors. Logarithmic fits were significantly better than linear fits for the global data and in most sectors. In preperimetric glaucoma, such correlations were weak and linear (R2 = 0.01-0.26). However, in perimetric glaucoma, the correlations were much stronger and curvilinear model gave the better fit (R2 = 0.15-0.84). Neuroretinal RA and RNFL thickness were linearly correlated.


CONCLUSIONS
Neuroretinal RA, RNFL thickness, and DLS in visual field were well correlated in POAG.
Li
Lüe
L
Department of Ophthalmology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Zhao
Jia-Liang
JL
Liu
Xiao-Li
XL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005902:Glaucoma, Open-Angle / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000473:pathology; D020795:Photophobia / Q000209:etiology*; D012044:Regression Analysis; D012160:Retina / Q000473:pathology*; D014794:Visual Fields / Q000502:physiology; D055815:Young Adult