[Immune status in hiv-infected patients with candidosis].
In order to identify changes in immune status in patients with HIV infection in combination with candidosis, 52 adult patients were investigated who were divided into three groups: HIV-positives with candidosis (n=22), HIV positives without concomitant disease (n=10) and control group (n=20). Immunological investigations included immunophenotyping of lymphocytes, assessment of activity of phagocytosis by NBT test, measuring levels of immunoglobulins and circulating immune complexes in the serum. It was shown that the reduction of the absolute numbers of CD3 + and CD4 + lymphocytes is accompanied by the disturbances in humoral immunity, which are expressed by the hyperproduction of IgG, IgM, IgA antibodies. In patients from both (1st and 2nd) groups an apparent decrease of immunoregulatory index (IRI) has been revealed in comparison to the control group. In HIV-infected patients with candidosis IRI value was 0.418+/-0.06 vs. 1.6+/-0.04 in controls. Increased levels of circulating immune complexes (CIC) and decline in NBT-test parameters were also observed. Phagocytic activity measured by NBT-test was lowered twice, and the level of CIC was 80.9+/-4.5 vs. 49.2+/-1.6 in controls.
Ibragimova
Sh G
ShG
Kadyrova
A A
AA
Nasrullaeva
G M
GM
Dadasheva
A E
AE
D000328:Adult; D017252:CD3 Complex / Q000276:immunology*; D002177:Candidiasis / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D007376:Interleukin-2 / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
D017252:CD3 Complex; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha