title: Spirobisnaphthalenes from the endophytic fungus Dzf12 of Dioscorea zingiberensis and their antimicrobial activities.
abstract: Five spirobisnaphthalenes, namely palmarumycin CP17 (1), diepoxin kappa (2), diepoxin eta (3), diepoxin xi (4), and diepoxin gamma (5), were isolated from the endophytic fungus Dzf12 associated with the medicinal plant Dioscorea zingiberensis C. H. Wright. Their structures were identified by physicochemical and spectrometric analysis. Among these spirobisnaphthalenes, 2 was found to have antibacterial activity, and the mixture of 3 and 4 was detected to have both antibacterial and antifungal activities.
authors.affiliation: College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China.
authors.forename: Xiaoyue
authors.initials: X
authors.lastname: Cai
authors.forename: Tijiang
authors.initials: T
authors.lastname: Shan
authors.forename: Peiqin
authors.initials: P
authors.lastname: Li
authors.forename: Yongfu
authors.initials: Y
authors.lastname: Huang
authors.forename: Lijian
authors.initials: L
authors.lastname: Xu
authors.forename: Ligang
authors.initials: L
authors.lastname: Zhou
authors.forename: Mingan
authors.initials: M
authors.lastname: Wang
authors.forename: Weibo
authors.initials: W
authors.lastname: Jiang
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D027742:Dioscorea / Q000382:microbiology*; D005285:Fermentation; D005658:Fungi / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000302:isolation & purification / Q000494:pharmacology*; D013141:Spiro Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D013172:Spores, Fungal / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009281:Naphthalenes; D013141:Spiro Compounds