title: Loa loa microfilarial periodicity in ivermectin-treated patients: comparison between those developing and those free of serious adverse events.
abstract: The main risk factor of post-ivermectin serious adverse events (SAEs) is the presence of a high Loa loa microfilaremia. However, the majority of patients with such high loads do not develop SAEs, suggesting that co-factors may be involved. An infection with simian Loa parasites, whose microfilariae show a nocturnal periodicity, might be such a co-factor. The periodicity of Loa microfilariae was compared, using cosinor methodology, in 4 patients who had developed a post-ivermectin neurologic SAE, 4 patients who had experienced a non-neurologic SAE, and 14 control individuals. The periodicity was similar in all three groups, with a peak of microfilaremia occurring between 12:30 and 2:00 PM. The results of this study, which for the first time characterizes the periodicity of Loa microfilariae mathematically, suggest that post-ivermectin SAEs are not related to an infection with a Loa simian strain.
authors.affiliation: Filariasis Research Centre, Yaoundé, Cameroon. jkamgno@yahoo.fr
authors.forename: Joseph
authors.initials: J
authors.lastname: Kamgno
authors.forename: Sébastien D
authors.initials: SD
authors.lastname: Pion
authors.forename: Charles D
authors.initials: CD
authors.lastname: Mackenzie
authors.forename: Björn
authors.initials: B
authors.lastname: Thylefors
authors.forename: Michel
authors.initials: M
authors.lastname: Boussinesq
mesh_terms: D000328:Adult; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D006801:Humans; D007559:Ivermectin / Q000627:therapeutic use*; D008117:Loa / Q000502:physiology*; D008118:Loiasis / Q000097:blood / Q000188:drug therapy* / Q000469:parasitology; D008875:Middle Aged; D010507:Periodicity; D055815:Young Adult
chemical_list: D000871:Anthelmintics; D007559:Ivermectin