Association of preoperative symptom profile with psychiatric symptoms following subthalamic nucleus stimulation in patients with Parkinson's disease.
In order to evaluate the severity of behavioral complications after deep brain stimulation of the subthalamic nucleus (STN-DBS) for Parkinson's disease and to explore possible predictive factors, the authors evaluated 22 patients for pre- and postoperative symptoms using a neurobehavioral battery. Compared to the time before STN-DBS, several behavioral symptoms had worsened in terms of prevalence and severity and appeared de novo in other patients. Apathy, anxiety, and suicidal ideation increased significantly, while depressive symptoms appeared stable. Compared with patients who improved, patients who had deteriorated behaviorally had similar prevalence and severity of preoperative behavioral symptoms but significantly shorter disease duration.
Porat
Omer
O
Department of Neurology & The Movement Disorders Unit, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel.
Cohen
Oren S
OS
Schwartz
Roseline
R
Hassin-Baer
Sharon
S
D000339:Affect; D000368:Aged; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D003863:Depression / Q000175:diagnosis; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000628:therapy*; D017060:Patient Satisfaction; D018579:Patient Selection; D011788:Quality of Life; D012307:Risk Factors; D012720:Severity of Illness Index; D012917:Social Adjustment; D018709:Statistics, Nonparametric; D020531:Subthalamic Nucleus / Q000601:surgery*; D016896:Treatment Outcome