High prevalence of autoantibodies against phosphoglycerate mutase 1 in patients with autoimmune central nervous system diseases.
We identified the autoantibody against phosphoglycerate mutase 1 (PGAM1), which is a glycolytic enzyme, in sera from multiple sclerosis (MS) patients by proteomics-based analysis. We further searched this autoantibody in sera from patients with other neurological diseases. The prevalence of the anti-PGAM1 antibody is much higher in patients with MS and neuromyelitis optica (NMO) than in those with other neurological diseases and in healthy controls. It was reported that the anti-PGAM1 antibody is frequently detected in patients with autoimmune hepatitis (AIH). Results of our study suggest that the anti-PGAM1 antibody is not only a marker of AIH but also a nonspecific marker of central nervous system autoimmune diseases.
Kimura
A
A
Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan. kimura1@gifu-u.ac.jp
Sakurai
T
T
Koumura
A
A
Yamada
M
M
Hayashi
Y
Y
Tanaka
Y
Y
Hozumi
I
I
Tanaka
R
R
Takemura
M
M
Seishima
M
M
Inuzuka
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D020278:Demyelinating Autoimmune Diseases, CNS / Q000097:blood* / Q000145:classification / Q000453:epidemiology / Q000276:immunology*; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D008875:Middle Aged; D009422:Nervous System Diseases / Q000097:blood / Q000276:immunology; D010736:Phosphoglycerate Mutase / Q000276:immunology*; D051381:Rats; D055815:Young Adult
D001323:Autoantibodies; D010736:Phosphoglycerate Mutase