title: Efficacy and safety of travoprost/timolol vs dorzolamide/timolol in patients with open-angle glaucoma or ocular hypertension.
abstract: OBJECTIVE
  To compare the intraocular pressure- (IOP-) lowering efficacy of fixed combinations travoprost 0.004%/timolol 0.5% and dorzolamide 2%/timolol 0.5% in patients with ocular hypertension or open-angle glaucoma.
  
  
  METHODS
  In this prospective, multicenter, double-masked, randomized clinical trial, 319 qualifying patients received either travoprost/timolol once daily in the morning (n = 157) or dorzolamide/timolol twice daily (n = 162). IOP was assessed morning and evening at 2 and 6 weeks. The primary outcome measure was mean diurnal IOP.
  
  
  RESULTS
  Baseline mean IOP values were similar between groups. Mean pooled diurnal IOP was significantly lower in the travoprost/timolol group (16.5 mmHg +/- 0.23) than in the dorzolamide/timolol group (17.3 mmHg +/- 0.23; P = 0.011). Mean IOP was significantly lower in the travoprost/timolol group compared to the dorzolamide/timolol group at the 9 AM time point both at Week 2 (P = 0.006) and Week 6 (P = 0.002). The travoprost/timolol combination produced mean IOP reductions from baseline of 35.3% to 38.5%, while the dorzolamide/timolol combination produced mean IOP reductions from baseline of 32.5% to 34.5%.
  
  
  CONCLUSIONS
  The fixed combination travoprost 0.004%/timolol 0.5% dosed once daily in the morning demonstrated superior mean diurnal IOP-lowering efficacy compared to dorzolamide 2%/timolol 0.5% dosed twice daily in patients with ocular hypertension or open-angle glaucoma.
authors.affiliation: Hospital Príncipe de Astúrias, Universidad de Alcalá, Madrid, Spain. mtg00003@teleline.es
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Teus
authors.forename: Stefano
authors.initials: S
authors.lastname: Miglior
authors.forename: Guna
authors.initials: G
authors.lastname: Laganovska
authors.forename: Lāsma
authors.initials: L
authors.lastname: Volksone
authors.forename: Bozena
authors.initials: B
authors.lastname: Romanowska-Dixon
authors.forename: Roman
authors.initials: R
authors.lastname: Gos
authors.forename: Gábor
authors.initials: G
authors.lastname: Holló