title: Fluorescence-guided surgery of metastatic brain tumors using fluorescein sodium.
abstract: We aimed to demonstrate the effectiveness of fluorescence-guided surgery of metastatic brain tumors using fluorescein sodium. The study comprised 38 patients with metastatic brain tumors who underwent tumor resection after intravenous injection of fluorescein sodium. The local recurrence rate was investigated in 36 of the 38 patients, and compared for patients who had undergone surgery only and surgery plus whole-brain radiotherapy (WBRT). In 31 of 36 patients, the tumors had been completely resected using fluorescence-guided surgery. Postoperative WBRT was not performed in 20 of the 31 patients who underwent gross total resection. Although the recurrence rate for these 20 patients was 20%, compared to 9.1% for the 11 patients who also underwent postoperative WBRT, the difference was not statistically significant. Use of fluorescein sodium in metastatic brain tumor surgery may reduce the rate of local recurrence, and thus help improve the quality of life for these patients.
authors.affiliation: Department of Neurosurgery, School of Medicine, Kinki University, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589 8511, Japan. Vince.g@nch.uni-wuerzburg.de
authors.forename: Takeshi
authors.initials: T
authors.lastname: Okuda
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kataoka
authors.forename: Tomonari
authors.initials: T
authors.lastname: Yabuuchi
authors.forename: Haruki
authors.initials: H
authors.lastname: Yugami
authors.forename: Amami
authors.initials: A
authors.lastname: Kato
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000503:physiopathology; D001932:Brain Neoplasms / Q000556:secondary* / Q000601:surgery*; D003131:Combined Modality Therapy; D003399:Craniotomy; D005260:Female; D019793:Fluorescein / Q000493:pharmacokinetics; D005453:Fluorescence; D006801:Humans; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000628:therapy; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control / Q000601:surgery; D019635:Neurosurgical Procedures / Q000379:methods*; D011878:Radiotherapy / Q000706:statistics & numerical data; D013194:Staining and Labeling / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D019793:Fluorescein