title: Frequent allelic loss of Dkk-1 locus (10q11.2) is related with low distant metastasis and better prognosis in head and neck squamous cell carcinomas.
abstract: Head and neck squamous cell carcinoma (HNSCC) is a frequently occurring cancer worldwide. Dickkopf (Dkk)-1 gene is suggested to function as tumor suppressor gene (TSG) in several kinds of malignancies. In this study, we performed loss of heterozygosity (LOH) analysis of Dkk-1 and examined the correlation between LOH status and clinicopathological parameters for the first time. A pretty high LOH ratio (50%) was detected. Interestingly, in the cases with Dkk-1 retention group showed less distant metastasis and a tendency of longer disease free survival. These results indicate that Dkk-1 can play a role in HNSCC carcinogenesis and it may also be related to distant metastasis.
authors.affiliation: Department of Oral pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8525, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Katase
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gunduz
authors.forename: Levent Bekir
authors.initials: LB
authors.lastname: Beder
authors.forename: Esra
authors.initials: E
authors.lastname: Gunduz
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Al Sheikh Ali
authors.forename: Ryo
authors.initials: R
authors.lastname: Tamamura
authors.forename: Kursat Oguz
authors.initials: KO
authors.lastname: Yaykasli
authors.forename: Noboru
authors.initials: N
authors.lastname: Yamanaka
authors.forename: Kenji
authors.initials: K
authors.lastname: Shimizu
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nagatsuka
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality / Q000556:secondary / Q000628:therapy; D002879:Chromosomes, Human, Pair 10; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005787:Gene Frequency; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000401:mortality / Q000556:secondary / Q000628:therapy; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D053208:Kaplan-Meier Estimate; D019656:Loss of Heterozygosity; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: C501126:DKK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins