title: Highly functionalized daphnane diterpenoids from Trigonostemon thyrsoideum.
abstract: Trigonothyrins A-C (1-3), which are highly functionalized daphnane diterpenoids, were isolated from the stems of Trigonostemon thyrsoideum. Compounds 1-3 represent the first examples of daphnanes with an oxygen-bridged four-membered-ring system, and a linkage mode of 12,13,14-orthoester. Compound 3 was observed to inhibit HIV-1 induced cytopathic effects. The EC(50) value was 2.19 microg/mL, and the therapeutic index (TI) was more than 90.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Rong-Hua
authors.initials: RH
authors.lastname: Luo
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Meng-Yuan
authors.initials: MY
authors.lastname: Jiang
authors.forename: Ze-Jun
authors.initials: ZJ
authors.lastname: Dong
authors.forename: Liu-Meng
authors.initials: LM
authors.lastname: Yang
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D004224:Diterpenes; C547176:trigonothyrin A; C547177:trigonothyrin B; C547178:trigonothyrin C