title: [Antibiotic prophylaxis in breast surgery. Preliminary resuls of a multicenter randomized study on 1400 cases].
abstract: Breast surgery is classified among the procedures performed in clean surgery and is associated with a low incidence of wound infection (3-15%). The objective of this study was to evaluate the advantages antibiotic prophylaxis in patients undergoing breast surgery. A multicenter randomized controlled study was performed between January 2008 and November 2008. One thousand four hundred patients were enrolled in prospective randomized study; surgical wound infection was found in 41 patients (2.93%). In our RCT we have shown that in breast surgery antibiotic prophylaxis does not present significant advantages in patients with potential risk of infection (17 patients, 2.42%, subjected to antibiotic prophylaxis vs 24 patients, 3.43%, without antibiotic prophylaxis) (P = 0.27). In patients with drainage there is a significant minor incidence of wound infections in patients receiving antibiotic prophylaxis (5 patients, 0.92%, subjected to antibiotic prophylaxis vs 14 patients, 3.09%, without antibiotic prophylaxis) (P = 0.02).
  
  
  CONCLUSIONS
  This study is only a preliminary RCT to be followed by a study which should be enrolled more patients in order to get the results as statistically significant.
authors.affiliation: SC Chirurgia Endocrina, Università degli Studi di Perugia. cirrocchiroberto@yahoo.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sanguinetti
authors.forename: Lodovico
authors.initials: L
authors.lastname: Rosato
authors.forename: Roberto
authors.initials: R
authors.lastname: Cirocchi
authors.forename: Francesco
authors.initials: F
authors.lastname: Barberini
authors.forename: Angela
authors.initials: A
authors.lastname: Pezzolla
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cavallaro
authors.forename: Domenico
authors.initials: D
authors.lastname: Parmeggiani
authors.forename: Roberto
authors.initials: R
authors.lastname: Ruggiero
authors.forename: Giovanni
authors.initials: G
authors.lastname: Docimo
authors.forename: Eugenio
authors.initials: E
authors.lastname: Procaccini
authors.forename: Antonio
authors.initials: A
authors.lastname: Santoriello
authors.forename: Antonio
authors.initials: A
authors.lastname: Rulli
authors.forename: Adelmo
authors.initials: A
authors.lastname: Gubitosi
authors.forename: Silvestro
authors.initials: S
authors.lastname: Canonico
authors.forename: Mario
authors.initials: M
authors.lastname: Taffurelli
authors.forename: Francesco
authors.initials: F
authors.lastname: Sciannameo
authors.forename: Alfonso
authors.initials: A
authors.lastname: Barbarisi
authors.forename: Ludovico
authors.initials: L
authors.lastname: Docimo
authors.forename: Massimo
authors.initials: M
authors.lastname: Agresti
authors.forename: Giorgio
authors.initials: G
authors.lastname: De Toma
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Noya
authors.forename: Umberto
authors.initials: U
authors.lastname: Parmeggiani
authors.forename: Nicola
authors.initials: N
authors.lastname: Avenia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001941:Breast Diseases / Q000601:surgery*; D001943:Breast Neoplasms / Q000601:surgery*; D002437:Cefazolin / Q000008:administration & dosage / Q000627:therapeutic use*; D019818:Clavulanic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D015409:Mastectomy, Radical; D015412:Mastectomy, Segmental; D008875:Middle Aged; D016017:Odds Ratio; D018579:Patient Selection; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D019818:Clavulanic Acid; D000658:Amoxicillin; D002437:Cefazolin