Corneal thickness and endothelial cell characteristics in patients with myotonic dystrophy.
OBJECTIVE
To compare the characteristics of the endothelial cells of patients with myotonic dystrophy and those of normal subjects to determine if thicker corneas in patients with myotonic dystrophy are the result of their having abnormal endothelial cells leading to corneal edema.


METHODS
Prospective, comparative case series.


METHODS
Fifty-two eyes of patients with myotonic dystrophy and 52 eyes of normal age- and gender-matched subjects.


METHODS
Central corneal thickness (CCT) and endothelial cell counts and shape were measured with an SP 3000P specular microscope (Topcon, Tokyo, Japan) in patients with myotonic dystrophy and were compared with those of age- and gender-matched healthy subjects.


METHODS
Central corneal thickness, endothelial cell counts, pleomorphism, and coefficient of variation (CoV).


RESULTS
In patients with myotonic dystrophy, the mean+/-standard deviation CCT measurement was 533+/-38 microm; the mean+/-standard deviation cell count was 2601+/-365 cell/mm(2); and the mean+/-standard deviation CoV was 23.3+/-4.4 (P<0.001). The mean+/-standard deviation pleomorphism was 64.4+/-8.4%. In healthy subjects, the mean+/-standard deviation CCT measurement was 514+/-27 microm (P = 0.002); the mean+/-standard deviation cell count was 2649+/-363 cell/mm(2) (P = 0.48); the mean+/-standard deviation CoV was 27.6+/-5.5 (P<0.001); and the mean+/-standard deviation pleomorphism was 61.1+/-8.6% (P = 0.04).


CONCLUSIONS
Thicker corneas found in patients with myotonic dystrophy are not related to endothelial number or appearance as assessed in this study.
Rosa
Nicola
N
Centro Grandi Apparecchiature, Second University of Naples, Naples, Italy. nicola.rosa@unina2.it
Lanza
Michele
M
Borrelli
Maria
M
Filosa
Maria Luisa
ML
De Bernardo
Maddalena
M
Ventriglia
Vega Maria
VM
Cecio
Maria Rosaria
MR
Politano
Luisa
L
D000328:Adult; D001837:Body Weights and Measures; D002452:Cell Count; D048430:Cell Shape; D003315:Cornea / Q000473:pathology*; D003316:Corneal Diseases / Q000150:complications* / Q000175:diagnosis; D004728:Endothelium, Corneal / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000150:complications* / Q000473:pathology; D011446:Prospective Studies