APOE-epsilon3 and APOE-219G haplotypes increase the risk for schizophrenia in sibling pairs.
To investigate the role of the apolipoprotein E (APOE) gene in schizophrenia, the authors analyzed 60 families with this mental disorder. An association in the presence of linkage test (APL) and haplotypes analysis were undertaken using the APL v1.1 software. A global allelic transmitted was significant for APOE-epsilon3 (chi(2)=6.24, p=0.01); this allele is mainly carried by female patients (chi(2)=8.33, p=0.003), whereas APOE-219G is preferentially transmitted in males (p=0.02). Furthermore, our results show that haplotypes APOE-epsilon3/APOE-219G are associated with schizophrenia (chi(2)=11.61, p=0.01). These results provide evidence that the APOE gene may play a significant role in the etiology of schizophrenia in the Mexican population.
Tovilla-Zarate
Carlos
C
Universidad Autónoma de la Ciudad de México, Escuela de Ciencias Genómicas, México D. F., México.
Medellin
Beatriz Camarena
BC
Fresan
Ana
A
Apiquian
Rogelio
R
Dassori
Albana
A
Rolando
Medina
M
Escamilla
Michael
M
Nicolini
Humberto
H
D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008800:Mexico; D018579:Patient Selection; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012559:Schizophrenia / Q000235:genetics*; D035781:Siblings
D001057:Apolipoproteins E