title: Vascular endothelial growth factor (VEGF) serum levels are associated with survival in early stages of lung cancer patients.
abstract: OBJECTIVE
  Evaluate the serum vascular endothelial growth factor (VEGF) levels in the prognosis of lung cancer patients.
  
  
  METHODS
  Fifty-four serum samples were analyzed for VEGF concentrations (79.3% nonsmall cell lung cancer (NSCLC) and 20.7% small cell lung cancer).
  
  
  RESULTS
  Patients with serum VEGF-A levels higher than the mean of the patients studied (434.93 pg/mL) presented a shorter median survival time than those with lower levels (p =.04), as in patients with NSCLC tumors (p =.04) and in those with stages I-II (p <.05), and high serum VEGF-A levels.
  
  
  CONCLUSIONS
  Elevated VEGF serum levels have a negative prognostic impact on survival in NSCLC and early stages of lung cancer patients.
authors.affiliation: Research Department, Ramón y Cajal Hospital, Madrid, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Carrillo-de Santa Pau
authors.forename: Fernando
authors.initials: F
authors.lastname: Carrillo Arias
authors.forename: Enrique
authors.initials: E
authors.lastname: Caso Pelaez
authors.forename: Ignacio
authors.initials: I
authors.lastname: Muguruza Trueba
authors.forename: Ignacio
authors.initials: I
authors.lastname: Sánchez Hernández
authors.forename: Gemma María
authors.initials: GM
authors.lastname: Muñoz Molina
authors.forename: Ramón
authors.initials: R
authors.lastname: Moreno Balsalobre
authors.forename: Silvia
authors.initials: S
authors.lastname: Sacristán López
authors.forename: Alejandro
authors.initials: A
authors.lastname: Gómez-Pinillos
authors.forename: Maria del Val
authors.initials: Mdel V
authors.lastname: Toledo Lobo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D042461:Vascular Endothelial Growth Factor A