title: Treatment of resistant obsessive-compulsive disorder with ventral capsular/ventral striatal gamma capsulotomy: a pilot prospective study.
abstract: A subgroup of obsessive-compulsive disorder (OCD) patients remains refractory to conventional treatments. For them, a new stereotactic radiosurgery has been recently developed: the ventral capsular/ventral striatal (VC/VS) gamma capsulotomy. The authors aim to report efficacy and adverse events of VC/VS gamma capsulotomy. Five refractory OCD patients were selected. The authors assessed OCD, anxiety and depressive symptoms, and side effects pre- and postoperatively. Three patients (60%) met response criteria 48 months after surgery. Adverse effects were episodic and transient. Ventral capsular/ventral striatal gamma capsulotomy holds therapeutic promise, with few adverse effects.
authors.affiliation: Obsessive Compulsive Spectrum Disorders Program (PROTOC), Department of Psychiatry, University of São Paulo School of Medicine, R. Dr. Ovídio Pires de Campos, 785, 3 degrees andar, sala 9, São Paulo, SP 01060-970, Brazil. antonioclopesmd@gmail.com
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Lopes
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Greenberg
authors.forename: Georg
authors.initials: G
authors.lastname: Norén
authors.forename: Miguel Montes
authors.initials: MM
authors.lastname: Canteras
authors.forename: Geraldo F
authors.initials: GF
authors.lastname: Busatto
authors.forename: Maria Eugênia
authors.initials: ME
authors.lastname: de Mathis
authors.forename: Anita
authors.initials: A
authors.lastname: Taub
authors.forename: Carina Chaubet
authors.initials: CC
authors.lastname: D'Alcante
authors.forename: Marcelo Queiroz
authors.initials: MQ
authors.lastname: Hoexter
authors.forename: Fernando Sauerbronn
authors.initials: FS
authors.lastname: Gouvea
authors.forename: Janaína Philippi
authors.initials: JP
authors.lastname: Cecconi
authors.forename: André F
authors.initials: AF
authors.lastname: Gentil
authors.forename: Ygor Arzeno
authors.initials: YA
authors.lastname: Ferrão
authors.forename: Daniel
authors.initials: D
authors.lastname: Fuentes
authors.forename: Cláudio Campi
authors.initials: CC
authors.lastname: de Castro
authors.forename: Cláudia C
authors.initials: CC
authors.lastname: Leite
authors.forename: João Victor
authors.initials: JV
authors.lastname: Salvajoli
authors.forename: Fábio L S
authors.initials: FL
authors.lastname: Duran
authors.forename: Steven
authors.initials: S
authors.lastname: Rasmussen
authors.forename: Eurípedes Constantino
authors.initials: EC
authors.lastname: Miguel
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D020772:Internal Capsule / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000601:surgery*; D010865:Pilot Projects; D011446:Prospective Studies; D016634:Radiosurgery; D016896:Treatment Outcome