Are GRIK3 (T928G) gene variants in schizophrenia patients different from those in their first-degree relatives?
We examined whether the GRIK3 (T928G) polymorphic variants in patients with schizophrenia are different from those of their first-degree relatives and healthy controls. The study population was composed of 256 patients with schizophrenia, 305 first-degree relatives of schizophrenia patients and 242 healthy control subjects. The GRIK3 (T928G) polymorphism was determined by restriction fragment length polymorphism. The frequency of the TT genotype was predominant, whereas the GG genotype was rare among all groups. The frequencies of GRIK3 (T928G) genotype distributions in the patients with schizophrenia were similar to those of their relatives. The frequency of the GG genotype was significantly higher in patients than in healthy controls. Similarly, GG genotype distribution in relatives was elevated compared with that in controls, but this value did not reach statistical significance. On the other hand, the subgroups of schizophrenia patients did not show a significant association with the GRIK3 (T928G) gene. It appears that the patients share the same (GRIK3) T928G gene variants with their relatives. One interpretation of our findings is that the relatives are at risk for the development of schizophrenia in the future.
Kilic
Gamze
G
Department of Genetics, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Ismail Kucukali
Cem
C
Orhan
Nurcan
N
Ozkok
Elif
E
Zengin
Asli
A
Aydin
Makbule
M
Kara
Ihsan
I
D000328:Adult; D005190:Family; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics*; D018092:Kainic Acid Receptors / Q000235:genetics*; D012044:Regression Analysis; D012559:Schizophrenia / Q000235:genetics*; D000097808:GluK3 Kainate Receptor
D018092:Kainic Acid Receptors; D000097808:GluK3 Kainate Receptor