Ménétrier disease in an acquired immunodeficiency syndrome patient.
Ménétrier disease is a rare disorder of unknown etiology. An overexpression of TGF-alpha has been proposed to play a role in the pathophysiology. HIV-1 tat gene product has been shown to stimulate TGF-alpha production leading to a positive feedback autocrine loop. The case of a 41-year-old male with AIDS who presented with weight loss, abdominal pain, ascites, edema, nausea, vomiting, and diarrhea is discussed. A computed tomography (CT) scan of the abdomen showed avid enhancement of the stomach mucosa. Magnetic resonance angiography revealed gastric and small bowel distention with diffuse wall thickening. Biopsies of the stomach showed marked foveolar hyperplasia with active inflammation and gland changes consistent with Ménétrier disease.
Duprey
Kevin M
KM
Department of Medicine, Lehigh Valley Hospital, Penn State University College of Medicine, Allentown, PA, USA.
Ahmed
Shameer
S
Mishriki
Yehia Yousri
YY
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005758:Gastritis, Hypertrophic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D008297:Male; D015282:Octreotide / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D005765:Gastrointestinal Agents; D015282:Octreotide; D011241:Prednisone