Structural and functional role of Staphylococcus aureus surface components recognizing adhesive matrix molecules of the host.
Staphylococcus aureus is a versatile and harmful human pathogen in both hospital- and community-acquired infections. S. aureus can initiate host infection by adhering to components of the extracellular matrix. Adherence is mediated by a variety of protein adhesins of the microbial surface component recognizing adhesive matrix molecule (MSCRAMM) family. In this article, we describe these MSCRAMMs in terms of structural organization and ligand-binding capacity and discuss their role as a possible target for immunotherapy.
Speziale
Pietro
P
Department of Biochemistry, 27100 Pavia, Italy. pspeziale@unipv.it
Pietrocola
Giampiero
G
Rindi
Simonetta
S
Provenzano
Maria
M
Provenza
Giulio
G
Di Poto
Antonella
A
Visai
Livia
L
Arciola
Carla Renata
CR
D018829:Adhesins, Bacterial / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D001422:Bacterial Adhesion; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D011485:Protein Binding; D020836:Protein Structure, Quaternary; D017434:Protein Structure, Tertiary; D013211:Staphylococcus aureus / Q000502:physiology*
D018829:Adhesins, Bacterial; D016326:Extracellular Matrix Proteins; C509820:MSCRAMM proteins, Staphylococcus