Il13 promoter (-1055) polymorphisms associated with chronic obstructive pulmonary disease in Taiwanese.
Interleukin-13 (IL13) -1055 polymorphism has been implicated in the development of chronic obstructive pulmonary disease (COPD) in various studies with conflicting results. The aims of this study are to investigate whether IL13 -1055 polymorphism is associated with the development of COPD in Taiwanese smokers; and to determine if IL13 -1055 polymorphism is associated with the severity of COPD. A case-control study was conducted on COPD patients (n = 85) and healthy smoker (n = 72). Genomic DNA was extracted for genotyping of IL13 sequencing and serum IL-13 was measured using by enzyme-linked immunosorbent assay (ELISA). After adjusting smoking index and age confounding, the T-allelic frequencies of the IL13 -1055 gene polymorphisms in COPD group are significantly higher than those in control group (18.8% versus 1.4%; P < .001; odds ratio [OR] = 29.3; 95% confidence interval [CI]: 5.9-145.3); and the frequencies of CT/TT genotypes in COPD group are significantly higher than those in control group (27.1% versus 2.8%; P < .001; OR = 20.0; 95% CI: 3.9-100.8). In COPD patients, stepwise linear regression shows IL13 -1055 T allele is the independent factor associated with forced expiratory volume in 1 second (P = .007), but not associated with serum IL-13. In conclusion, IL13 -1055 T allele is associated with the development and severity of COPD in Taiwanese smokers.
Liu
Shih-Feng
SF
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan.
Chen
Yung-Che
YC
Wang
Chin-Chou
CC
Fang
Wen-Feng
WF
Chin
Chien-Hung
CH
Su
Mao-Chang
MC
Lin
Meng-Chih
MC
D000368:Aged; D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers / Q000235:genetics; D005541:Forced Expiratory Volume; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D018793:Interleukin-13 / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000235:genetics* / Q000276:immunology* / Q000503:physiopathology; D012907:Smoking / Q000009:adverse effects; D013624:Taiwan
D017931:DNA Primers; D018793:Interleukin-13