Spirobisnaphthalenes from the endophytic fungus Dzf12 of Dioscorea zingiberensis and their antimicrobial activities.
Five spirobisnaphthalenes, namely palmarumycin CP17 (1), diepoxin kappa (2), diepoxin eta (3), diepoxin xi (4), and diepoxin gamma (5), were isolated from the endophytic fungus Dzf12 associated with the medicinal plant Dioscorea zingiberensis C. H. Wright. Their structures were identified by physicochemical and spectrometric analysis. Among these spirobisnaphthalenes, 2 was found to have antibacterial activity, and the mixture of 3 and 4 was detected to have both antibacterial and antifungal activities.
Cai
Xiaoyue
X
College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China.
Shan
Tijiang
T
Li
Peiqin
P
Huang
Yongfu
Y
Xu
Lijian
L
Zhou
Ligang
L
Wang
Mingan
M
Jiang
Weibo
W
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D027742:Dioscorea / Q000382:microbiology*; D005285:Fermentation; D005658:Fungi / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000302:isolation & purification / Q000494:pharmacology*; D013141:Spiro Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D013172:Spores, Fungal / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009281:Naphthalenes; D013141:Spiro Compounds