Deep magnetic capture of magnetically loaded cells for spatially targeted therapeutics.
Magnetic targeting has recently demonstrated potential in promoting magnetically loaded cell delivery to target lesion, but its application is limited by magnetic attenuation. For deep magnetic capture of cells for spatial targeting therapeutics, we designed a magnetic pole, in which the magnetic field density can be focused at a distance from the pole. As flowing through a tube served as a model of blood vessels, the magnetically loaded mesenchymal stem cells (MagMSCs) were highly enriched at the site distance from the magnetic pole. The cell capture efficiency was positively influenced by the magnetic flux density, and inversely influenced by the flow velocity, and well-fitted with the deductive value by theoretical considerations. It appeared to us that the spatially-focused property of the magnetic apparatus promises a new deep targeting strategy to promote homing and engraftment for cellular therapy.
Huang
Zheyong
Z
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai 200032, China.
Pei
Ning
N
Wang
Yanyan
Y
Xie
Xinxing
X
Sun
Aijun
A
Shen
Li
L
Zhang
Shuning
S
Liu
Xuebo
X
Zou
Yunzeng
Y
Qian
Juying
J
Ge
Junbo
J
D000818:Animals; D001808:Blood Vessels / Q000033:anatomy & histology; D002478:Cells, Cultured; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D016503:Drug Delivery Systems; D006801:Humans; D008280:Magnetics / Q000295:instrumentation / Q000379:methods; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D053768:Metal Nanoparticles; D008953:Models, Anatomic; D008962:Models, Theoretical; D051381:Rats; D017207:Rats, Sprague-Dawley
D004337:Drug Carriers