Imaging approaches for the study of cell-based cardiac therapies.
Despite promising preclinical data, the treatment of cardiovascular diseases using embryonic, bone-marrow-derived, and skeletal myoblast stem cells has not yet come to fruition within mainstream clinical practice. Major obstacles in cardiac stem cell investigations include the ability to monitor cell engraftment and survival following implantation within the myocardium. Several cellular imaging modalities, including reporter gene and MRI-based tracking approaches, have emerged that provide the means to identify, localize, and monitor stem cells longitudinally in vivo following implantation. This Review will examine the various cardiac cellular tracking modalities, including the combinatorial use of several probes in multimodality imaging, with a focus on data from the past 5 years.
Lau
Joe F
JF
The Zena and Michael A. Wiener Cardiovascular Institute and Marie-Josée and Henry R. Kravis Cardiovascular Health Center, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.
Anderson
Stasia A
SA
Adler
Eric
E
Frank
Joseph A
JA
D000818:Animals; D003287:Contrast Media; D003952:Diagnostic Imaging / Q000379:methods; D052203:Ferrosoferric Oxide; D005682:Gadolinium; D017930:Genes, Reporter; D006331:Heart Diseases / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009206:Myocardium / Q000473:pathology*; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D012038:Regeneration; D033581:Stem Cell Transplantation; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D003287:Contrast Media; D005682:Gadolinium; D052203:Ferrosoferric Oxide