title: Health risk assessment of ochratoxin A for all age-sex strata in a market economy.
abstract: In order to manage risk of ochratoxin A (OTA) in foods, we re-evaluated the tolerable daily intake (TDI), derived the negligible cancer risk intake (NCRI), and conducted a probabilistic risk assessment. A new approach was developed to derive 'usual' probabilistic exposure in the presence of highly variable occurrence data, such as encountered with low levels of OTA. Canadian occurrence data were used for various raw food commodities or finished foods and were combined with US Department of Agriculture (USDA) food consumption data, which included data on infants and young children. Both variability and uncertainty in input data were considered in the resulting exposure estimates for various age/sex strata. Most people were exposed to OTA on a daily basis. Mean adjusted exposures for all age-sex groups were generally below the NCRI of 4 ng OTA kg bw(-1), except for 1-4-year-olds as a result of their lower body weight. For children, the major contributors of OTA were wheat-based foods followed by oats, rice, and raisins. Beer, coffee, and wine also contributed to total OTA exposure in older individuals. Predicted exposure to OTA decreased when European Commission maximum limits were applied to the occurrence data. The impact on risk for regular eaters of specific commodities was also examined.
authors.affiliation: Health Canada, HPFB, Food Directorate, Bureau of Chemical Safety, Ottawa, ON, K1A 0L2, Canada. kuiper.tineke@gmail.com
authors.forename: T
authors.initials: T
authors.lastname: Kuiper-Goodman
authors.forename: C
authors.initials: C
authors.lastname: Hilts
authors.forename: S M
authors.initials: SM
authors.lastname: Billiard
authors.forename: Y
authors.initials: Y
authors.lastname: Kiparissis
authors.forename: I D K
authors.initials: ID
authors.lastname: Richard
authors.forename: S
authors.initials: S
authors.lastname: Hayward
mesh_terms: D000367:Age Factors; D000818:Animals; D002170:Canada; D015197:Carcinogenicity Tests; D005260:Female; D005506:Food Contamination; D006801:Humans; D008297:Male; D009152:Mutagenicity Tests; D009183:Mycotoxins / Q000633:toxicity*; D009793:Ochratoxins / Q000633:toxicity*; D018570:Risk Assessment; D012737:Sex Factors
chemical_list: D009183:Mycotoxins; D009793:Ochratoxins; C025589:ochratoxin A