title: A novel combination of mild electrical stimulation and hyperthermia: general concepts and applications.
abstract: This review discusses the basic concepts, effects and applications of hyperthermia and mild electrical stimulation (MES) using low-intensity direct current. It also proposes a novel combinatorial use of MES and hyperthermia, and briefly outlines the rationale and the effects of MES and hyperthermia combination treatment on certain diseases (diabetes, hepatic ischaemia/reperfusion injury and gastric ulcer). The integrated modalities of MES and hyperthermia might find therapeutic applications to stress-induced diseases and intractable diseases of dysregulated signalling pathways.
authors.affiliation: Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto, Japan. hirokai@gpo.kumamoto-u.ac.jp
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kai
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Suico
authors.forename: Saori
authors.initials: S
authors.lastname: Morino
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kondo
authors.forename: Mariko
authors.initials: M
authors.lastname: Oba
authors.forename: Mikiko
authors.initials: M
authors.lastname: Noguchi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Shuto
authors.forename: Eiichi
authors.initials: E
authors.lastname: Araki
mesh_terms: D000818:Animals; D004599:Electric Stimulation Therapy; D006979:Hyperthermia, Induced; D007328:Insulin / Q000502:physiology; D051379:Mice; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology; D015427:Reperfusion Injury / Q000628:therapy; D015398:Signal Transduction
chemical_list: D007328:Insulin; D051057:Proto-Oncogene Proteins c-akt