title: Type I interferons as mediators of immune adjuvants for T- and B cell-dependent acquired immunity.
abstract: Originally identified as antiviral substances produced by infected cells, type I interferons (IFN-I) are now known to have a wide range of additional activities within both the innate and adaptive immune response. Here we review properties of IFN-I contributing to their 'natural immune adjuvant' character, and their important role for the function of complete Freund's adjuvant (CFA) and the TLR9-dependent immune adjuvant IC31. We show data to demonstrate that treatment with IFN-I boosts the ability of vaccine/adjuvant combinations to induce peptide-specific CTL in both young and old mice. We view these findings in the perspective of previous clinical applications of IFN-I for vaccination.
authors.affiliation: Department of Pharmacology, Medical University of Vienna, Austria; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
authors.forename: Michaela
authors.initials: M
authors.lastname: Prchal
authors.forename: Andreas
authors.initials: A
authors.lastname: Pilz
authors.forename: Olivia
authors.initials: O
authors.lastname: Simma
authors.forename: Karen
authors.initials: K
authors.lastname: Lingnau
authors.forename: Alexander
authors.initials: A
authors.lastname: von Gabain
authors.forename: Birgit
authors.initials: B
authors.lastname: Strobl
authors.forename: Mathias
authors.initials: M
authors.lastname: Müller
authors.forename: Thomas
authors.initials: T
authors.lastname: Decker
mesh_terms: D056704:Adaptive Immunity; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D004338:Drug Combinations; D005620:Freund's Adjuvant / Q000276:immunology; D007370:Interferon Type I / Q000276:immunology*; D051379:Mice; D009838:Oligodeoxyribonucleotides; D009842:Oligopeptides; D013601:T-Lymphocytes / Q000276:immunology*; D014612:Vaccines / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D004338:Drug Combinations; C544002:IC31 adjuvant; D007370:Interferon Type I; D009838:Oligodeoxyribonucleotides; D009842:Oligopeptides; D014612:Vaccines; D005620:Freund's Adjuvant