Wound healing potential of methanolic extract of Trichosanthes dioica Roxb (fruits) in rats.
OBJECTIVE
The present study provides a scientific evaluation for the wound healing potential of methanolic (MeOH) extract of TDR fruits.


METHODS
Excision and incision wounds were inflicted upon three groups of six rats each. Group I was assigned as control (ointment base), Group II was treated with standard silver sulfadiazine (0.01%) cream. Group III was treated with 5% MeOH extract ointment. The parameters observed were percentage of wound contraction, epithelialization period, hydroxyproline content, tensile strength including histopathological studies.


RESULTS
It was noted that the effect produced by the extract ointment showed significant (P<0.01) healing in both the wound models when compared with control group. All parameters such as wound contraction, epithelialization period, hydroxyproline content, tensile strength and histopathological studies showed significant changes when compared to control.


CONCLUSIONS
The result shows that TDR extract ointment demonstrates wound healing potential in both excision and incision models.
Shivhare
Yogesh
Y
Division of Phytochemistry and Pharmacognosy, VNS Institute of Pharmacy, Neelbud, Bhopal, MP, India.
Singour
Pradeep K
PK
Patil
U K
UK
Pawar
R S
RS
D000279:Administration, Cutaneous; D000818:Animals; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005638:Fruit; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D012837:Silver Sulfadiazine / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D013718:Tensile Strength / Q000187:drug effects; D029778:Trichosanthes / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000378:metabolism
D003879:Dermatologic Agents; D010936:Plant Extracts; D006909:Hydroxyproline; D012837:Silver Sulfadiazine