Fast intra-axonal transport: Beginning, development and post-genome advances.
The review describes the initial experiments suggesting a fast intra-axonal transport of transmitter related substances, in addition to the "classic" slow flow. Early experiments were mainly conducted in the peripheral adrenergic system, focusing on transport of amine storage granules, the extent of the vast sympathetic adrenergic system and the importance of axonal transport of amine granules for the adrenergic system. Further, it describes important advances obtained from studies of other neuron systems regarding local axonal protein synthesis, motor proteins and new insights regarding relation between faults in the transport machinery and some neuropathological conditions.
Dahlstrom
Annica B
AB
Hults Gata 98, S-436 44 ASKIM Gothenburg-Askim, Sweden. annica.dahlstrom@anatcell.gu.se
D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D001679:Biogenic Amines / Q000378:metabolism; D016678:Genome / Q000502:physiology*; D006651:Histocytochemistry / Q000266:history / Q000379:methods; D049673:History, 20th Century; D049674:History, 21st Century; D008959:Models, Neurological; D009420:Nervous System / Q000166:cytology*; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure*; D018377:Neurotransmitter Agents / Q000235:genetics / Q000378:metabolism*
D001679:Biogenic Amines; D018377:Neurotransmitter Agents