title: Synthesis of glycoside derivatives of hydroxyanthraquinone with ability to dissolve and inhibit formation of crystals of calcium oxalate. Potential compounds in kidney stone therapy.
abstract: Synthesis of glycosyl derivatives of hydroxyanthraquinones (6-10) potentially useful for kidney stone therapy is presented. These compounds were analyzed as inhibitors of calcium oxalate crystals formation as well as substances with the ability of dissolving crystalline calcium oxalate. In addition, the effect of the compounds obtained on real kidney stones was analyzed by ex vivo tests. The tests on L929 and A545 cell lines have shown that the compounds obtained were not cytotoxic.
authors.affiliation: Medicinal Chemistry and Microbiology Department, Wroclaw University of Technology, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Frackowiak
authors.forename: Przemysław
authors.initials: P
authors.lastname: Skibiński
authors.forename: Wiesław
authors.initials: W
authors.lastname: Gaweł
authors.forename: Ewa
authors.initials: E
authors.lastname: Zaczyńska
authors.forename: Anna
authors.initials: A
authors.lastname: Czarny
authors.forename: Roman
authors.initials: R
authors.lastname: Gancarz
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002129:Calcium Oxalate / Q000037:antagonists & inhibitors* / Q000737:chemistry; D002460:Cell Line; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007669:Kidney Calculi / Q000188:drug therapy; D051379:Mice; D015394:Molecular Structure; D012995:Solubility
chemical_list: D000880:Anthraquinones; D006027:Glycosides; D002129:Calcium Oxalate; C061208:1-hydroxyanthraquinone