title: Giant, solid, invasive prolactinoma in a prepubescent boy with gynecomastia.
abstract: Pituitary adenomas are extremely rare in prepubescent children. Most of these tumors are functioning adenomas, but can also present with vision disturbances and changes in body morphology. We discuss the presentation, management, and outcome of a giant, solid, invasive prolactinoma in a 7-year-old boy who presented with visual disturbances and gynecomastia. The child demonstrated significant improvement in vision and a reduction in size of the tumor after subtotal tumor decompression and treatment with oral bromocriptine for 4 months. Tumor decompression and oral dopamine agonist therapy comprise the accepted treatment for pediatric prolactinomas. To our knowledge, only two previous reports described a giant prolactinoma in a prepubescent child. The relevant literature on pediatric pituitary tumours and prolactinoma is reviewed.
authors.affiliation: Department of Neurosurgery, Sri Satya Sai Institute of Higher Medical Sciences, Bangalore, Karnataka 560066, India. sunilvf@gmail.com
authors.forename: Sunil V
authors.initials: SV
authors.lastname: Furtado
authors.forename: Narayanam A
authors.initials: NA
authors.lastname: Saikiran
authors.forename: Nandita
authors.initials: N
authors.lastname: Ghosal
authors.forename: Alangar S
authors.initials: AS
authors.lastname: Hegde
mesh_terms: D017668:Age of Onset; D002648:Child; D018491:Dopamine Agonists / Q000627:therapeutic use; D005500:Follow-Up Studies; D006177:Gynecomastia / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D006728:Hormones / Q000097:blood; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010902:Pituitary Gland / Q000473:pathology / Q000601:surgery; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D015175:Prolactinoma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D011627:Puberty; D016896:Treatment Outcome; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology / Q000628:therapy
chemical_list: D018491:Dopamine Agonists; D006728:Hormones