title: Enantioselective synthesis of 3,4-dihydroisoquinolin-1(2H)-ones by nickel-catalyzed denitrogenative annulation of 1,2,3-benzotriazin-4(3H)-ones with allenes.
abstract: A denitrogenative annulation reaction of 1,2,3-benzotriazin-4(3H)-ones with allenes catalyzed by a nickel-phosphine complex to produce a variety of substituted 3,4-dihydroisoquinolin-1(2H)-ones in a regioselective manner is described. A highly enantioselective version, as well as structural evidence for the mechanistic course of this reaction, is also presented.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Katsura, Kyoto 615-8510, Japan.
authors.forename: Motoshi
authors.initials: M
authors.lastname: Yamauchi
authors.forename: Masao
authors.initials: M
authors.lastname: Morimoto
authors.forename: Tomoya
authors.initials: T
authors.lastname: Miura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Murakami