title: Re-irradiation of metastatic spinal cord compression: a feasibility study by volumetric-modulated arc radiotherapy for in-field recurrence creating a dosimetric hole on the central canal.
abstract: When local recurrences arise within an irradiated region involving metastatic spinal cord compression, the dose limit to the spinal cord reduces the chance to re-treat the patient by 3D-conformational RT technique. The possibility of using volumetric modulated arc RT by RapidArc was evaluated for dose sparing at spinal cord level and preserving target coverage. A clinically satisfactory PTV coverage and dose sparing to the spinal cord were obtained. An upcoming trial on patients will provide clinical outcomes.
authors.affiliation: IRCCS Istituto Clinico Humanitas, Radiation Oncology, Via Manzoni 56, 20098 Rozzano, Italy. pietro.mancosu@humanitas.it
authors.forename: Pietro
authors.initials: P
authors.lastname: Mancosu
authors.forename: Piera
authors.initials: P
authors.lastname: Navarria
authors.forename: Mario
authors.initials: M
authors.lastname: Bignardi
authors.forename: Luca
authors.initials: L
authors.lastname: Cozzi
authors.forename: Antonella
authors.initials: A
authors.lastname: Fogliata
authors.forename: Paola
authors.initials: P
authors.lastname: Lattuada
authors.forename: Armando
authors.initials: A
authors.lastname: Santoro
authors.forename: Gaetano
authors.initials: G
authors.lastname: Urso
authors.forename: Sabrina
authors.initials: S
authors.lastname: Vigorito
authors.forename: Marta
authors.initials: M
authors.lastname: Scorsetti
mesh_terms: D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D011874:Radiometry; D019233:Retreatment; D013117:Spinal Cord Compression / Q000209:etiology / Q000532:radiotherapy*; D016896:Treatment Outcome