Controlling biological networks by time-delayed signals.
This paper describes the use of time-delayed feedback to regulate the behaviour of biological networks. The general ideas on specific transcriptional regulatory and neural networks are demonstrated. It is shown that robust yet tunable controllers can be constructed that provide the biological systems with model-engineered inputs. The results indicate that time delay modulation may serve as an efficient biocompatible control tool.
Orosz
Gábor
G
Department of Mechanical Engineering, University of California, Santa Barbara, CA 93106, USA. gabor@engineering.ucsb.edu
Moehlis
Jeff
J
Murray
Richard M
RM
D000465:Algorithms; D057005:Bioengineering; D025461:Feedback, Physiological; D053263:Gene Regulatory Networks; D016571:Neural Networks, Computer; D015398:Signal Transduction; D049490:Systems Biology; D013997:Time Factors