title: Effectiveness of a mouthwash containing Triclosan and Gantrez in the reduction of biofilm and gingivitis: a clinical pilot study.
abstract: OBJECTIVE
  The aim of this pilot study was to evaluate the effectiveness of a mouthwash containing Triclosan and Gantrez in the reduction of bacterial biofilm and gingivitis.
  
  
  METHODS
  Thirty patients were assigned to control and experimental groups. The visible plaque index and the marginal bleeding index were determined at the baseline, and at the second and third months, at which time a percentage of bacterial plaque and bleeding was obtained for each patient. All patients were given unlabeled toothpaste without Triclosan and Gantrez and soft-bristle toothbrushes. Additionally, the experimental group patients used unlabeled mouthwash with Triclosan and Gantrez. The participants were instructed to rinse for 60 seconds after brushing, twice a day.
  
  
  RESULTS
  At the baseline, the control and experimental group's bacterial plaque and marginal bleeding indices were close to each other (46.61% and 50.75% respectively; 7.62% and 9.59% respectively). At the third month, the experimental group presented bacterial plaque and marginal bleeding indices of 6.56% and 0.43% respectively, while the control presented 11.37% and 2.41% respectively. There were no significant differences between the two groups (p>0.05), with a discrete tendency to better results in the experimental group for both variables. However, there were significant differences among the experimental periods (p<0.05), except between the second and third months of observation.
  
  
  CONCLUSIONS
  The mouthwash did not bring forth an additional advantage when combined with brushing. Additional studies where the observation period may be prolonged and the number of subjects increased are recommended.
  
  
  CONCLUSIONS
  It is important to understand the role chemical control of supragingival plaque can play as an aid in the treatment of periodontal diseases. Since bacterial biofilm is the primary etiological factor in gingivitis and periodontitis, it is essential to know how to control it in order to provide a more complete therapeutic strategy for patient care.
authors.affiliation: Department of Periodontics, School of Dentistry, Universidad Evangélica de El Salvador, San Salvador, El Salvador. acevedoroberto@hotmail.com
authors.forename: Roberto
authors.initials: R
authors.lastname: Andrade Acevedo
authors.forename: Lourdes
authors.initials: L
authors.lastname: Machón
authors.forename: Natália
authors.initials: N
authors.lastname: Chávez
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001565:Benzoates / Q000737:chemistry / Q000627:therapeutic use; D018441:Biofilms / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D003741:Dental Deposits / Q000188:drug therapy* / Q000517:prevention & control; D005260:Female; D005891:Gingivitis / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D008297:Male; D008298:Maleates / Q000737:chemistry / Q000627:therapeutic use*; D009067:Mouthwashes / Q000737:chemistry / Q000627:therapeutic use*; D010865:Pilot Projects; D011109:Polymethacrylic Acids / Q000737:chemistry / Q000627:therapeutic use; D011145:Polyvinyls / Q000737:chemistry / Q000627:therapeutic use*; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry / Q000627:therapeutic use; D016896:Treatment Outcome; D014260:Triclosan / Q000737:chemistry / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D001565:Benzoates; D003692:Delayed-Action Preparations; D008298:Maleates; D009067:Mouthwashes; C070868:Plax; D011109:Polymethacrylic Acids; D011145:Polyvinyls; C516721:poly(1-vinylimidazole-co-methyl methacrylate) copolymer; C058026:polyvinylmethoxyethylene-maleic anhydride copolymer; D012967:Sodium Dodecyl Sulfate; D014260:Triclosan