title: Acetylcholinesterase inhibitory pyridine alkaloids of the leaves of Senna multijuga.
abstract: Two unusual pyridine alkaloids, 7'-multijuguinone (1) and 12'-hydroxy-7'-multijuguinone (2), were isolated from the leaves of Senna multijuga, together with the known flavonoid rutin. The structures of the new alkaloids were established on the basis of spectroscopic data interpretation. Compounds 1 and 2 exhibited moderate in vitro acetylcholinesterase (AChE) inhibitory activity, in comparison with the standard compound physostigmine.
authors.affiliation: Sao Paulo State University (UNESP), Araraquara, SP, Brazil.
authors.forename: Maria A R
authors.initials: MA
authors.lastname: Serrano
authors.forename: Marcos
authors.initials: M
authors.lastname: Pivatto
authors.forename: Welington
authors.initials: W
authors.lastname: Francisco
authors.forename: Amanda
authors.initials: A
authors.lastname: Danuello
authors.forename: Luis O
authors.initials: LO
authors.lastname: Regasini
authors.forename: Elaine M C
authors.initials: EM
authors.lastname: Lopes
authors.forename: Marcia N
authors.initials: MN
authors.lastname: Lopes
authors.forename: Maria C M
authors.initials: MC
authors.lastname: Young
authors.forename: Vanderlan S
authors.initials: VS
authors.lastname: Bolzani
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001938:Brazil; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029846:Senna Plant / Q000737:chemistry*
chemical_list: C548944:12'-hydroxy-7'-multijuguinone; C548943:7'-multijuguinone; D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D011725:Pyridines; D000110:Acetylcholinesterase