title: Antimicrobials and BRD.
abstract: Pharmacodynamics is limited with respect to its ability to provide precise predictions to guide therapy because of complications related to the bound versus unbound state of the agent, tissue versus plasma concentrations, drug degradation over time, variations among microorganisms, and factors associated with the specific environment at the infection site. Antimicrobial susceptibility testing is likewise imprecise when applied to an individual animal; however, it is valuable on an animal population basis.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA. mapley@ksu.edu
authors.forename: Mike
authors.initials: M
authors.lastname: Apley
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D048090:Bovine Respiratory Disease Complex / Q000188:drug therapy* / Q000382:microbiology; D002417:Cattle; D008826:Microbial Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents