[Leptin serum levels in cachectic and non-cachectic lung cancer patients].
BACKGROUND
Leptin, protein taking part in body mass regulation, might play a role in cancer cachexia development. The aim of the study was to measure leptin serum levels in cachectic, non-cachectic lung cancer patients, healthy controls and to correlate leptin concentration with nutritional status markers.


METHODS
40 lung cancer patients were enrolled into the study: 20 with cachexia, 20 without cachexia, and 10 healthy controls. Leptin serum concentration, body mass, BMI, arm circumference and skin triceps fold thickness were measured in each subject.


RESULTS
Serum leptin level in cachectic cancer patients was significantly lower than in non-cachectic and healthy controls. Leptin concentration correlated with body mass, arm circumference and skin triceps fold thickness.


CONCLUSIONS
Cachectic lung cancer patients have significantly lower serum leptin concentrations than non-cachectic patients and healthy controls which may suggest, that leptin does not play an important role in cancer cachexia development. Leptin levels positively correlate with good nutritional status markers. Non-cachectic lung cancer patients have similar leptin serum levels as healthy controls.
Weryńska
Bozena
B
Kosacka
Monika
M
Gołecki
Marcin
M
Jankowska
Renata
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002100:Cachexia / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D055815:Young Adult
D015415:Biomarkers; D020738:Leptin