Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.
A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron isotropic resolution. The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies.
Samei
Ehsan
E
Duke University, Durham, NC, USA. samei@duke.edu
Saunders
Robert S
RS
Badea
Cristian T
CT
Ghaghada
Ketan B
KB
Hedlund
Laurence W
LW
Qi
Yi
Y
Yuan
Hong
H
Bentley
Rex C
RC
Mukundan
Srinivasan
S
D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media; D005260:Female; D007479:Iopamidol / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D015674:Mammary Neoplasms, Animal / Q000000981:diagnostic imaging*; D008327:Mammography / Q000379:methods*; D053758:Nanoparticles; D011856:Radiographic Image Enhancement / Q000379:methods*; D051381:Rats; D011916:Rats, Inbred F344; D014057:Tomography, X-Ray Computed / Q000379:methods*
D003287:Contrast Media; D008081:Liposomes; D007479:Iopamidol