STING-ing the antiviral pathway.
The cytosolic DNA sensing pathway has remained poorly defined thus far. A recent study by Ishikawa et al. demonstrates that STING is essential for DNA-mediated type I IFN production and host defence against DNA pathogens.
Nakhaei
Peyman
P
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, QC, Canada.
Hiscott
John
J
Lin
Rongtuan
R
D000818:Animals; D004267:DNA Viruses / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D007113:Immunity, Innate; D016899:Interferon-beta / Q000096:biosynthesis*; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D012328:RNA Viruses / Q000502:physiology*; D015398:Signal Transduction; D000099197:STING Protein
D016899:Interferon-beta; D008565:Membrane Proteins; C530855:Sting1 protein, mouse; D000099197:STING Protein