title: Extracytoplasmic PAS-like domains are common in signal transduction proteins.
abstract: We present the crystal structure of the extracytoplasmic domain of the Bacillus subtilis PhoR sensor histidine kinase, part of a two-component system involved in adaptation to low environmental phosphate concentrations. In addition to the PhoR structure, we predict that the majority of the extracytoplasmic domains of B. subtilis sensor kinases will adopt a fold similar to the ubiquitous PAS domain.
authors.affiliation: Biosciences Division, Argonne National Laboratory, Argonne, Illinois 60439, USA.
authors.forename: Changsoo
authors.initials: C
authors.lastname: Chang
authors.forename: Christine
authors.initials: C
authors.lastname: Tesar
authors.forename: Minyi
authors.initials: M
authors.lastname: Gu
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Babnigg
authors.forename: Andrzej
authors.initials: A
authors.lastname: Joachimiak
authors.forename: P Raj
authors.initials: PR
authors.lastname: Pokkuluri
authors.forename: Hendrik
authors.initials: H
authors.lastname: Szurmant
authors.forename: Marianne
authors.initials: M
authors.lastname: Schiffer
mesh_terms: D000595:Amino Acid Sequence; D001412:Bacillus subtilis / Q000737:chemistry* / Q000235:genetics; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011494:Protein Kinases / Q000737:chemistry* / Q000235:genetics; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment
chemical_list: D001426:Bacterial Proteins; C061279:PhoR protein, Bacteria; D011494:Protein Kinases