title: The porcine small intestinal submucosa (SIS) patch in foot and ankle reconstruction.
abstract: We undertook a retrospective cohort study of 54 patients who underwent foot and ankle soft tissue reconstructive surgery augmented with a porcine small intestinal submucosal (SIS) patch. The mean patient age was 44 (range 17 to 68) years, there were 21 (38.89%) males in the cohort, and the mean follow-up duration was 1080 (range 365 to 1943) days. Clinical outcomes were considered excellent in 46 (85.19%) patients, good/fair in 3 (5.56%) patients, and poor in 5 (9.26%) patients; and no adverse events attributable to the xenograft were observed. Direct SIS patch failure, resulting in stretching of the repair, re-tear, or tendon stenosis, occurred in 3 (5.56%) patients, and delayed incision healing occurred in 6 (11.11%) patients. Based on our observations, we concluded that the porcine SIS xenograft, when used to augment cellular and vascular in-growth, is a viable adjunct to musculoskeletal reconstructions of the foot and ankle.
authors.affiliation: Foot & Ankle Section, Department of Orthopaedics, Marshfield Clinic, Marshfield, WI, USA. bibbo.christopher@marshfieldclinic.org
authors.forename: Christopher
authors.initials: C
authors.lastname: Bibbo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000842:Ankle / Q000601:surgery*; D001705:Bioprosthesis / Q000009:adverse effects; D005260:Female; D005528:Foot / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019651:Plastic Surgery Procedures / Q000379:methods; D013710:Tendons / Q000601:surgery; D014945:Wound Healing; D055815:Young Adult