CMV infection presenting as a cavitary lung lesion in a patient with systemic lupus erythematosus receiving immunosuppressive therapy.
We report a case of cytomegalovirus (CMV) pneumonitis that presented as a cavitary lung lesion in a patient with systemic lupus erythematosus receiving immunosuppressive treatment. The lesion was confirmed by positive polymerase chain reaction (PCR) for CMV in bronchoalveolar lavage fluid (BALF) and CMV antigenemia. PCR for CMV in BALF was demonstrated to be useful for the diagnosis of CMV pneumonitis on the basis of high sensitivity and specificity. After initiating ganciclovir, the lesion gradually regressed. A cavitary lung lesion associated with CMV is extremely rare. This presentation suggests that the differential diagnosis of cavitary lung lesion in immunocompromised individuals should include CMV.
Azuma
Naoto
N
Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya. naoazuuh@hyo-med.ac.jp
Hashimoto
Naoaki
N
Yasumitsu
Akihiro
A
Fukuoka
Kazuya
K
Yokoyama
Kazunori
K
Sawada
Hisashi
H
Nishioka
Aki
A
Sekiguchi
Masahiro
M
Kitano
Masayasu
M
Kuroiwa
Takanori
T
Matsui
Kiyoshi
K
Sano
Hajime
H
D000998:Antiviral Agents / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000821:virology; D003586:Cytomegalovirus Infections / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
D000998:Antiviral Agents; D007166:Immunosuppressive Agents