title: Effects of oral creatine and resistance training on serum myostatin and GASP-1.
abstract: Myostatin is a catabolic regulator of skeletal muscle mass. The purpose of this study was to determine the effect of resistance training for 8 weeks in conjunction with creatine supplementation on muscle strength, lean body mass, and serum levels of myostatin and growth and differentiation factor-associated serum protein-1 (GASP-1). In a double-blinded design 27 healthy male subjects (23.42+/-2.2 years) were assigned to control (CON), resistance training+placebo (RT+PL) and resistance training+creatine supplementation (RT+CR) groups. The protocol consisted of 3 days per week of training for 8 weeks, each session including three sets of 8-10 repetitions at 60-70% of 1 RM for whole-body exercise. Blood sampling, muscular strength testing and body composition analysis (full body DEXA) were performed at 0, 4th and 8th weeks. Myostatin and GASP-1 was measured. Resistance training caused significant decrease in serum levels of myostatin and increase in that of GASP-1. Creatine supplementation in conjunction with resistance training lead to greater decreases in serum myostatin (p<0.05), but had not additional effect on GASP-1 (p>0.05). The effects of resistance training on serum levels of myostatin and GASP-1, may explain the increased muscle mass that is amplified by creatine supplementation.
authors.affiliation: Department of Sport Science, Arak University, Arak, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Saremi
authors.forename: R
authors.initials: R
authors.lastname: Gharakhanloo
authors.forename: S
authors.initials: S
authors.lastname: Sharghi
authors.forename: M R
authors.initials: MR
authors.lastname: Gharaati
authors.forename: B
authors.initials: B
authors.lastname: Larijani
authors.forename: K
authors.initials: K
authors.lastname: Omidfar
mesh_terms: D000284:Administration, Oral; D001823:Body Composition / Q000187:drug effects; D003401:Creatine / Q000008:administration & dosage* / Q000494:pharmacology* / Q000652:urine; D004032:Diet; D019587:Dietary Supplements; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D053580:Muscle Strength / Q000187:drug effects; D055435:Myostatin / Q000097:blood*; D011506:Proteins / Q000378:metabolism*; D055070:Resistance Training; D033921:Vesicular Transport Proteins / Q000097:blood*; D055815:Young Adult
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D055435:Myostatin; D011506:Proteins; D033921:Vesicular Transport Proteins; C424444:WFIKKN2 protein, human; D003401:Creatine