title: [Oral sedation with midazolam in blepharoplasty].
abstract: OBJECTIVE
  To evaluate the safety and usefulness of the use of oral sedation with midazolam (15 mg) in patients submitted to blepharoplasty.
  
  
  METHODS
  Randomized double-blind prospective study of 42 patients (surgical risk ASA I and II) divided into three groups of 14 patients each: Group M (midazolam 15 mg), group P (placebo) and group SM (no medication). All patients were evaluated according to the degree of sedation and pain during surgery and the variation of anxiety between the preoperative and intraoperative period, arterial pressure (systolic-SAP and diastolic-DAP), respiratory frequency (RF) and pulsation.
  
  
  RESULTS
  Unifatorial variance analysis with Tukey test demonstrated that the use of midazolam provoked a significant SAP and RF reduction during the intraoperative period. These effects were not pronounced and were accompanied by a reduction of pain perception and anxiety and mild sedation.
  
  
  CONCLUSIONS
  Oral sedation with midazolam in patients that had undergone eyelid surgical procedures is safe and easy to perform with minimal systemic effects.
authors.affiliation: Departamento de Oftalmologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
authors.forename: Rejane Dantas Rodrigues
authors.initials: RD
authors.lastname: Gonçalves
authors.forename: Antonio Augusto Velasco E
authors.initials: AA
authors.lastname: Cruz
mesh_terms: D000759:Adjuvants, Anesthesia / Q000008:administration & dosage*; D000284:Administration, Oral; D001007:Anxiety / Q000378:metabolism; D019882:Blepharoplasty; D001794:Blood Pressure / Q000187:drug effects; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008874:Midazolam / Q000008:administration & dosage*; D010146:Pain / Q000378:metabolism; D011300:Preoperative Care; D012119:Respiration / Q000187:drug effects
chemical_list: D000759:Adjuvants, Anesthesia; D008874:Midazolam