title: Excessive appetitive arousal in Prader-Willi syndrome.
abstract: This study focused on genetic and behavioural aspects of one important component of the motivation to eat - how appetitive arousal is elicited through the presentation of food-associated stimuli. Individuals with Prader-Willi syndrome, a genetic disorder associated with hyperphagia, and control participants completed a computerised response task in the presence of motivational stimuli. In controls, appetitive arousal was specific to particular stimuli. In contrast, individuals with PWS showed a non-specific pattern of arousal. Over-activation of the anticipatory motivation system may be one consequence of the genetic disorder in PWS.
authors.affiliation: Wales Institute of Cognitive Neuroscience, School of Psychology, Cardiff University, Park Place, Cardiff CF103AT, UK. hintone@cardiff.ac.uk
authors.forename: E C
authors.initials: EC
authors.lastname: Hinton
authors.forename: A R
authors.initials: AR
authors.lastname: Isles
authors.forename: N M
authors.initials: NM
authors.lastname: Williams
authors.forename: J A
authors.initials: JA
authors.lastname: Parkinson
mesh_terms: D000328:Adult; D001066:Appetite; D001143:Arousal; D003463:Cues; D005247:Feeding Behavior / Q000523:psychology*; D005260:Female; D006801:Humans; D006815:Hunger; D006963:Hyperphagia / Q000150:complications / Q000523:psychology*; D008297:Male; D009042:Motivation; D010775:Photic Stimulation / Q000379:methods; D011218:Prader-Willi Syndrome / Q000150:complications / Q000523:psychology*; D011795:Surveys and Questionnaires; D013647:Task Performance and Analysis