Inherited dyslipidaemic disorders contributing to coronary heart disease.
BACKGROUND
Lipoprotein (a) [Lp (a)] is an established independent risk factor for premature myocardial infarction (MI)/coronary artery disease (CAD). The study was conducted to determine the value of Lp (a) in prediction of CAD or MI in the offspring at risk.


METHODS
A total of 160 subjects were investigated. Serum Lp (a) was measured by ELISA, serum total cholesterol, triglycerides (TG) and HDL-Cholesterol by enzymatic colorimetric methods using standard kits.


RESULTS
Differences in levels of total Lp (a) and cholesterol were observed between patients and controls. Both Lp (a) (16.23 +/-1.95 mg/dL) and cholesterol (175.00 +/- 7.60 mg/dL) of group A (patients) were higher than the corresponding controls. However an opposite trend in results was noted for serum HDL-Cholesterol in patients vs. controls.


CONCLUSIONS
Persons found to have elevated levels of Lp (a) should focus on controlling the known modifiable risk factor for heart disease, especially smoking, hypercholesterolemia, obesity, hypertension and sedentary life style.
Attaullah
Salma
S
Department of Chemical Pathology, Hayatabad Medical Complex, Peshawar, Pakistan.
Bangash
Rahim
R
Amanullah
Ahmed
Zahoor
Z
Rehman
Jamilur
J
D000328:Adult; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood / Q000235:genetics; D003324:Coronary Artery Disease / Q000097:blood / Q000235:genetics*; D050171:Dyslipidemias / Q000097:blood / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D017270:Lipoprotein(a); D002784:Cholesterol