Two Rabs for exosome release.
Exosomes are endosome-derived membrane vesicles that are key for intercellular communication in the immune system and elsewhere. Rab27A and Rab27B GTPases and two of their cognate effector proteins seem to be needed to drive the physiologically important exosome-release process in certain cell types.
Pfeffer
Suzanne R
SR
D002450:Cell Communication; D011992:Endosomes; D055354:Exosomes / Q000502:physiology*; D006801:Humans; D020691:rab GTP-Binding Proteins / Q000378:metabolism*; D000075745:rab27 GTP-Binding Proteins
D000075745:rab27 GTP-Binding Proteins; C066694:RAB27A protein, human; C512960:Rab27B protein, human; D020691:rab GTP-Binding Proteins