title: Innovations in radiotherapy planning of head and neck cancers: role of PET.
abstract: Modern radiotherapy techniques heavily rely on high-quality medical imaging. PET provides biologic information about the tumor, complementary to anatomic imaging. Integrated PET/CT has found its way into the practice of radiation oncology, and (18)F-FDG PET is being introduced for radiotherapy planning. The functional information possibly augments accurate delineation and treatment of the tumor and its extensions while reducing the dose to surrounding healthy tissues. In addition to (18)F-FDG, other PET tracers are available for imaging specific biologic tumor characteristics determining radiation resistance. For head and neck cancer, the potential gains of PET are increasingly being recognized. This review describes the current role of PET and perspectives on its future use for selection and delineation of radiotherapy target volumes and for biologic characterization of this tumor entity. Furthermore, the potential role of PET for early response monitoring, treatment modification, and patient selection is addressed in this review.
authors.affiliation: Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands. e.troost@rther.umcn.nl
authors.forename: Esther G C
authors.initials: EG
authors.lastname: Troost
authors.forename: Dominic A X
authors.initials: DA
authors.lastname: Schinagl
authors.forename: Johan
authors.initials: J
authors.lastname: Bussink
authors.forename: Otto C
authors.initials: OC
authors.lastname: Boerman
authors.forename: Albert J
authors.initials: AJ
authors.lastname: van der Kogel
authors.forename: Wim J G
authors.initials: WJ
authors.lastname: Oyen
authors.forename: Johannes H A M
authors.initials: JH
authors.lastname: Kaanders
mesh_terms: D015687:Cell Hypoxia; D049109:Cell Proliferation; D019788:Fluorodeoxyglucose F18; D006258:Head and Neck Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics; D010347:Patient Care Planning; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow; D014057:Tomography, X-Ray Computed
chemical_list: D009363:Neoplasm Proteins; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18