title: Making mixtures to solve structures: structural elucidation via combinatorial synthesis.
abstract: A domino Horner-Wadsworth-Emmons olefination strategy has been used to prepare homologous series of (polyen)ones, and through combinatorial elaboration, corresponding families of highly branched hydrocarbons. Gas chromatography-mass spectrometry of the mixtures has enabled the rapid and unambiguous identification of several highly branched alkanes of geochemical importance. This is the first example of the use of combinatorial synthesis for the elucidation of structural connectivity.
authors.affiliation: Chemistry, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Perth, Western Australia 6009, Australia.
authors.forename: Nigel A
authors.initials: NA
authors.lastname: Lengkeek
authors.forename: Paul F
authors.initials: PF
authors.lastname: Greenwood
authors.forename: Blake
authors.initials: B
authors.lastname: Nguyen
authors.forename: George A
authors.initials: GA
authors.lastname: Koutsantonis
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Piggott
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D018360:Crystallography, X-Ray; D008401:Gas Chromatography-Mass Spectrometry; D015394:Molecular Structure; D011126:Polypropylenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000473:Alkanes; D011126:Polypropylenes