Serologic response to rabies pre-exposure vaccination in persons with potential occupational exposure in Singapore.
Sixty-six animal workers received primary rabies vaccination with purified Vero cell vaccine (PVRV, Verorab). One year later, 26 (39%) demonstrated antibody titers below the recommended minimum of 0.5 IU/ml, and required a booster. All 15 of a separate group reporting primary vaccination with at least one booster had titers above 0.5 IU/ml 1 year later, demonstrating long-term boostable immunity. Rabies antibody titers should be checked 1 year after primary rabies vaccination in persons at high risk of frequent rabies exposure. If access to serological surveillance is unavailable, such high-risk individuals should receive booster vaccination.
Lim
Poh Lian
PL
Department of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433 Singapore. pllim@post.harvard.edu
Barkham
Timothy M S
TM
D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002522:Chlorocebus aethiops; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D011818:Rabies / Q000276:immunology / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology*; D012846:Singapore; D014709:Vero Cells
D000914:Antibodies, Viral; D011819:Rabies Vaccines