title: Ranibizumab for coloboma-related choroidal neovascular membrane in a child.
abstract: Optic nerve and retinochoroidal coloboma are caused by incomplete closure of the embryonic fissure during fetal development.(1) Affected patients carry a risk for retinal detachment and less so for choroidal neovascular membranes (CNVM) secondary to the altered anatomy. Because of the rarity of this condition and the even more unusual occurrence of such complications, there are only a few case reports on the treatment of coloboma-related CNVM. Herein we report the results of ranibizumab and laser photocoagulation for coloboma-related CNVM in a child.
authors.affiliation: Ocular Oncology, Wills Eye Institute, Thomas Jefferson University, 840 Walnut Street, Philadelphia, PA 19107, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Goodwin
authors.forename: Carol L
authors.initials: CL
authors.lastname: Shields
authors.forename: Aparna
authors.initials: A
authors.lastname: Ramasubramanian
authors.forename: Gary C
authors.initials: GC
authors.lastname: Brown
authors.forename: Jerry A
authors.initials: JA
authors.lastname: Shields
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D002829:Choroid / Q000002:abnormalities*; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D003103:Coloboma / Q000150:complications*; D003131:Combined Modality Therapy; D005451:Fluorescein Angiography; D006801:Humans; D007223:Infant; D007267:Injections; D017075:Laser Coagulation; D008297:Male; D011379:Prognosis; D000069579:Ranibizumab; D012160:Retina / Q000002:abnormalities*; D019233:Retreatment; D014822:Vitreous Body
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000069579:Ranibizumab