title: [PICK1 is associated with central nervous system diseases].
abstract: PICK1 (protein interacting with C kinase 1) contains a PDZ (PSD-95/Dlg/ZO1) domain and a BAR (Bin/amphiphysin/Rvs) domain. Via the PDZ domain, PICK1 interacts directly with more than 40 proteins. Among these interacting proteins, some are important for physiological and pathophysiological processes of central nervous system. In this review, recent findings about how PICK1 is associated with central nervous system diseases are summarize.
authors.affiliation: Institute of Neuroscience, College of Medicine, Zhejiang University, Hangzhou 310058, China.
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Lu
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Zhu
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D004827:Epilepsy / Q000378:metabolism*; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D012559:Schizophrenia / Q000378:metabolism; D020521:Stroke / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D009687:Nuclear Proteins; C498297:PICk1 protein, human