Central leptin receptor action and resistance in obesity.
The discovery of leptin in 1994 has led to remarkable advances in obesity research. We now know that leptin is a cytokinelike hormone that is produced in adipose tissue and plays a pivotal role in regulation of energy balance and in a variety of additional processes via actions in the central nervous system. This symposium review covers current understandings of neuronal leptin receptor signaling and mechanisms of obesity-related leptin resistance in the central nervous system and provides recent insights into the regulation of peripheral glucose balance by central leptin action in rodents.
Bjørbaek
Christian
C
Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. cbjorbae@bidmc.harvard.edu
D000818:Animals; D001921:Brain / Q000502:physiology; D004351:Drug Resistance / Q000235:genetics; D020738:Leptin / Q000502:physiology; D009765:Obesity / Q000235:genetics / Q000503:physiopathology*; D011333:Pro-Opiomelanocortin / Q000502:physiology; D054411:Receptors, Leptin / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction
D020738:Leptin; D054411:Receptors, Leptin; D011333:Pro-Opiomelanocortin