Proliferation and survival of rat C6 glioma culture in the presence of implants coated with modified carbon-based films.
The survival of rat C6 glioma decreased in the presence of implants from VT-16 titanium alloy. Diamond-like carbon coating of VT-16 alloy slightly increased cell death on day 5 of the experiment (39.9+/-2.1%). The percentage of dead C6 glioma cells inside titanium rings with diamond-like carbon coating, incorporating up to 3.5 atom.% Ag nanoparticles, was 53.7+/-4.3% on day 5 of culturing, while after doping to 6.7 atom.% Ag cell death reached 66.7+/-3.2% (p<0.05). The maximum toxic effect towards C6 glioma was detected in the specimens coated with diamond-like film with silver nanoparticles.
Pozdniak
L V
LV
Department of Physiology and General Pathology, Institute of Physiology, National Academy of Sciences of Belarus, Minsk, Russia.
Chernov
A N
AN
Chekan
N M
NM
Beliauski
N M
NM
Akulich
V V
VV
Poljanskaya
G G
GG
Gordienko
A I
AI
Kulchitsky
V A
VA
D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D002244:Carbon / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005910:Glioma / Q000473:pathology*; D053768:Metal Nanoparticles / Q000633:toxicity; D051381:Rats; D012834:Silver / Q000737:chemistry; D014025:Titanium / Q000633:toxicity*
D001672:Biocompatible Materials; D012834:Silver; D002244:Carbon; D014025:Titanium