title: Reduced cerebellar diameter in very preterm infants with abnormal general movements.
abstract: BACKGROUND
  Abnormal General Movements (GMs) early in life are predictive of later neuromotor deficits and are related to white matter abnormalities on magnetic resonance imaging (MRI). However, other structural correlates of abnormal GMs have not been defined.
  
  
  OBJECTIVE
  The objective of this study was to explore brain-metrics (linear brain measurements on MRI representative of 3-D brain volumes) at term as a predictor of abnormal GMs at 1 and 3months' corrected age in preterm infants. It was hypothesized that abnormal GMs would be related to reduced brain-metrics in primary motor areas, namely the cerebellum and parietal lobes.
  
  
  METHODS
  Eighty three preterm infants (<30weeks' gestational age) were scanned at term-equivalent age. MRI was assessed for white matter abnormality and brain-metrics in six predefined brain regions (i.e. bifrontal, biparietal, lateral ventricles and transverse cerebellar diameters, and inter-hemispheric distance).
  
  
  METHODS
  At 1 and 3months' corrected age infants' GMs were assessed from video-taped footage and rated as normal or abnormal using standardized methodology.
  
  
  RESULTS
  At 1month, 63% (n=52) of infants had abnormal GMs with no association between any of the brain-metrics and abnormal GMs. At 3months, 23% (n=18) of infants had abnormal GMs (absent fidgety movements n=18; abnormal fidgety movements n=0). Reduced bifrontal, biparietal, and cerebellar transverse diameters, along with an increase in lateral ventricle sizes were associated with an increased risk of abnormal GMs at 3months' corrected age. After controlling for white matter abnormality and grade III/IV intraventricular haemorrhage, only the cerebellar transverse diameter was predictive of abnormal GMs at 3months.
  
  
  CONCLUSIONS
  Reduced cerebellar diameter at term equivalent age is related to abnormal GMs at 3months' corrected age, independent of white matter abnormality and intraventricular haemorrhage.
authors.affiliation: Murdoch Childrens Research Institute, Victoria, Australia. aspittle@unimelb.edu.au <aspittle@unimelb.edu.au>
authors.forename: Alicia J
authors.initials: AJ
authors.lastname: Spittle
authors.forename: Lex W
authors.initials: LW
authors.lastname: Doyle
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Anderson
authors.forename: Terrie E
authors.initials: TE
authors.lastname: Inder
authors.forename: Katherine J
authors.initials: KJ
authors.lastname: Lee
authors.forename: Roslyn N
authors.initials: RN
authors.lastname: Boyd
authors.forename: Jeanie L Y
authors.initials: JL
authors.lastname: Cheong
mesh_terms: D000367:Age Factors; D002531:Cerebellum / Q000473:pathology*; D020820:Dyskinesias / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008279:Magnetic Resonance Imaging; D009068:Movement; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D016017:Odds Ratio; D009929:Organ Size