title: A simplified three-times weekly daptomycin dosing regimen for chronic hemodialysis patients.
abstract: Approximately 2.3 million patients worldwide are undergoing chronic renal replacement therapy. In that population, acute infections substantially contribute to the excessive morbidity and mortality. The risk for invasive methicillin-resistant Staphylococcus aureus infections in this population is approximately 100-fold higher than in the general population, therefore dialysis patients currently account for up to approximately 15% of all invasive methicillin-resistant Staphylococcus aureus infections. A simplified three-times weekly dosing regimen for hemodialysis patients now allows for practical, hassle-free and effective treatment with daptomycin, which is licensed for the treatment of complicated skin and soft tissue infections, including resistant strains of Staphylococcus aureus and life-threatening Gram-positive infections, vancomycin-resistant enterococcal infections and right-sided endocarditis.
authors.affiliation: Department of Pulmonary Medicine, Medical School Hannover, Germany. burkhardt.olaf@mh-hannover.de
authors.forename: Olaf
authors.initials: O
authors.lastname: Burkhardt
authors.forename: Jan T
authors.initials: JT
authors.lastname: Kielstein