title: Differential complication rates following radical cystectomy in the irradiated and nonirradiated pelvis.
abstract: BACKGROUND
  Reports suggest that cystectomy following pelvic irradiation is associated with a higher morbidity and mortality than in primary cases. However, such reports are from an era when postcystectomy complication rates were higher than are currently reported.
  
  
  OBJECTIVE
  This study evaluates perioperative complications and mortality in primary radical and postradiation salvage cystectomy.
  
  
  METHODS
  Patients treated with cystectomy for bladder cancer or advanced pelvic malignancies involving the bladder were studied.
  
  
  METHODS
  Perioperative complications and mortality were analysed for 426 primary and 420 salvage cystectomies performed at a single institution between 1970 and 2005.
  
  
  CONCLUSIONS
  The 30- and 60-d mortality in the 2000-2005 cohort were 0% and 1.2%, respectively, in the primary group and 1.4% and 4.3%, respectively, in the salvage cystectomy group. Thirty-day mortality between 1970 and 2005 was not statistically significant in the primary and salvage groups (4.2% and 7.1%, respectively).
  
  
  CONCLUSIONS
  This large series from a high-volume centre demonstrates no difference in perioperative mortality in primary or postradiation salvage radical cystectomy. Similarly, there was no significant difference in the incidence of most of the surgical or medical complications in either group, although the stomal stenosis rate was higher postradiation.
authors.affiliation: The Christie Hospital NHS Foundation Trust, Manchester, United Kingdom. vacramani@gmail.com
authors.forename: Vijay A C
authors.initials: VA
authors.lastname: Ramani
authors.forename: Satish B
authors.initials: SB
authors.lastname: Maddineni
authors.forename: Ben R
authors.initials: BR
authors.lastname: Grey
authors.forename: Noel W
authors.initials: NW
authors.lastname: Clarke
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery*; D002295:Carcinoma, Transitional Cell / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery*; D015653:Cystectomy / Q000009:adverse effects* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010385:Pelvic Exenteration / Q000009:adverse effects* / Q000401:mortality; D011183:Postoperative Complications; D018714:Radiotherapy, Adjuvant; D012086:Reoperation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D016879:Salvage Therapy; D001749:Urinary Bladder Neoplasms / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery*