title: A novel ruthenium(III) complex with a tridentate dianionic P,O,O-ligand showing high cytotoxic activity.
abstract: Tris(o-anisyl)phosphane was reacted with ruthenium(III) chloride forming a novel Ru(III) complex of formula [Ru(PAn(3))(P(An)(phenolate)(2))Cl] containing a tridentate dianionic P,O,O-ligand and a bidentate neutral P,O ligand. The tridentate ligand was formed by elimination of two methyl groups from the starting ligand in the reaction with the ruthenium salt. The molecular structure was determined by single crystal X-ray diffraction analysis. The compound shows a high cytotoxic activity in ovarian cancer cell lines comparable with cisplatin and overcoming cisplatin-resistance.
authors.affiliation: Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, 2300 Leiden, The Netherlands.
authors.forename: Jimmy A
authors.initials: JA
authors.lastname: van Rijn
authors.forename: Patricia
authors.initials: P
authors.lastname: Marqués-Gallego
authors.forename: Jan
authors.initials: J
authors.lastname: Reedijk
authors.forename: Martin
authors.initials: M
authors.lastname: Lutz
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Spek
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Bouwman
mesh_terms: D000838:Anions / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry / Q000633:toxicity*; D018360:Crystallography, X-Ray; D006801:Humans; D008024:Ligands; D008968:Molecular Conformation; D010100:Oxygen / Q000737:chemistry*; D010758:Phosphorus / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000838:Anions; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D010758:Phosphorus; D012428:Ruthenium; D010100:Oxygen