title: [Trisomy 8 in chronic lymphocytic leukemia].
abstract: OBJECTIVE
  To investigate the incidence of trisomy 8 in chronic lymphocytic leukemia (CLL) and its significance in prognosis.
  
  
  METHODS
  A panel of probes and fluorescence in situ hybridization (FISH) were used to detect trisomy 8 in 151 CLL patients combined with chromosome karyotype analysis.
  
  
  RESULTS
  There were 2 patients (1.3%) with trisomy 8 in the 151 CLL patients, and the number of trisomy 8 cells was 8% and 10% respectively. The karyotypes were 47,XY,+8[2]/49,XY,+14,+20,+21[2]/ 46,XY[16], and 47,XX,+8[2]/46,XX[18], respectively.
  
  
  CONCLUSIONS
  Trisomy 8 was rare in CLL, and its significance in prognosis of CLL still remains unknown.
authors.affiliation: Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029 P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Cao
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Liu
authors.forename: Dan-xia
authors.initials: DX
authors.lastname: Zhu
authors.forename: Chun
authors.initials: C
authors.lastname: Qiao
authors.forename: Yu-jie
authors.initials: YJ
authors.lastname: Wu
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Qiu
authors.forename: Jian-yong
authors.initials: JY
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014314:Trisomy