NF-kappaB signalling: embracing complexity to achieve translation.
NF-kappaB is a dimeric transcription factor that has emerged as an important regulator of liver homeostasis and is mechanistically implicated in a variety of liver pathologies including hepatitis, steatosis, fibrosis, and hepatocellular carcinoma. The question remains as to whether NF-kappaB can really be exploited for the development of therapeutics for these pathologies in the diseased human liver. This review casts a critical eye on the experimental evidence gathered to date and in particular questions the rationale for the current focus on components of the upstream IKK complex as therapeutic targets. We make the argument that translation of NF-kappaB biology to new therapies is more likely to emerge from a re-focus of basic research back to the NF-kappaB/Rel subunit functions and the complexities of their post-translational modifications and context-dependent co-regulator interactions.
Chakraborty
Jayashree Bagchi
JB
Liver Research Group, Institute of Cellular Medicine, 4th Floor, Catherine Cookson Building, Medical School, Newcastle University, UK.
Mann
Derek A
DA
D000818:Animals; D006801:Humans; D051550:I-kappa B Kinase / Q000737:chemistry / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008107:Liver Diseases / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D016328:NF-kappa B / Q000737:chemistry / Q000378:metabolism*; D014176:Protein Biosynthesis; D021122:Protein Subunits; D015398:Signal Transduction
D016328:NF-kappa B; D021122:Protein Subunits; D051550:I-kappa B Kinase