title: [Toxic maculopathy caused by antimalarial drugs: detection using spectral domain OCT: case reports].
abstract: Antimalarial drugs, such as chloroquine, are useful in the management of rheumatic diseases, but may cause a potentially blinding condition known as toxic maculopathy. This report describes the findings on standard and on high-resolution spectral domain ocular coherence tomography performed in a CirrusTM HD-OCTdevice in two patients with chloroquine maculopathy. In one case, a very similar aspect of retinal pigment epithelium (RPE) plaque atrophy occured in both angiographic and HD-OCT images obtained by 'en-face' (coronal) segmentation. In another patient with clinical signs of maculopathy and no angiographic abnormalities, signs of RPE atrophy could also be observed in HD-OCT scans, raising the possibility that this technique may allow the early detection of the disease.
authors.affiliation: Escola de Medicina, Santa Casa de Misericórdia de Vitória, Vitória, ES, Brasil. biccas@terra.com.br
authors.forename: Laurentino
authors.initials: L
authors.lastname: Biccas Neto
authors.forename: Arthur Silva de
authors.initials: AS
authors.lastname: Mesquita
mesh_terms: D000962:Antimalarials / Q000009:adverse effects*; D002738:Chloroquine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012164:Retinal Diseases / Q000139:chemically induced*; D055213:Retinal Pigment Epithelium / Q000187:drug effects* / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods
chemical_list: D000962:Antimalarials; D002738:Chloroquine