Effect of successive increase in alcohol chains on reaction with isocyanates and isothiocyanates.
The reaction of isocyanates and isothiocyanates with long-chain alcohols, e.g. n-hexanol, n-heptanol and n-octanol, exclusively gave N-aryl-O-alkyl carbamates, while N-aryl-O-alkyl carbamates were formed along with symmetrical 1,3-disubstituted ureas and thioureas when the same reactions were carried out with small-chain alcohols at room temperature without using any solvent.
Perveen
Shahnaz
S
PCSIR Laboratories Complex, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi, Pakistan. dr_shahnaz_perveen@yahoo.com
Yasmin
Arfa
A
Khan
Khalid Mohammed
KM
D002219:Carbamates / Q000138:chemical synthesis; D002855:Chromatography, Thin Layer; D005233:Fatty Alcohols / Q000737:chemistry*; D007202:Indicators and Reagents; D017953:Isocyanates / Q000737:chemistry*; D017879:Isothiocyanates / Q000737:chemistry*; D012997:Solvents; D013696:Temperature; D013890:Thiourea / Q000737:chemistry; D014508:Urea / Q000737:chemistry
D002219:Carbamates; D005233:Fatty Alcohols; D007202:Indicators and Reagents; D017953:Isocyanates; D017879:Isothiocyanates; D012997:Solvents; D014508:Urea; D013890:Thiourea