title: Concise assembly of linear alpha(1-->6)-linked octamannan fluorescent probe.
abstract: Synthesis of a fluorescently labelled (dansylated) linear alpha(1-->6)-linked octamannan, using glycosyl fluoride donors and thioglycosyl acceptors is described. A selective and convergent two-stage activation progression was executed to construct di-, tetra and octa-mannosyl thioglycosides in three glycosylation steps with excellent yield. Further a 5-N,N-Dimethylaminonaphthalene-1-sulfonamidoethyl (dansyl) group was coupled to 1-azidoethyl octamannosyl thioglycoside. Global deprotection of the coupled product afforded the desired dansylated homo-linear alpha(1-->6)-linked octamannan.
authors.affiliation: Department of Chemistry, Western IllinoisUniversity, Macomb, IL 61455, USA.
authors.forename: Mohammad S
authors.initials: MS
authors.lastname: Aqueel
authors.forename: Vibha
authors.initials: V
authors.lastname: Pathak
authors.forename: Ashish K
authors.initials: AK
authors.lastname: Pathak