[PICK1 is associated with central nervous system diseases].
PICK1 (protein interacting with C kinase 1) contains a PDZ (PSD-95/Dlg/ZO1) domain and a BAR (Bin/amphiphysin/Rvs) domain. Via the PDZ domain, PICK1 interacts directly with more than 40 proteins. Among these interacting proteins, some are important for physiological and pathophysiological processes of central nervous system. In this review, recent findings about how PICK1 is associated with central nervous system diseases are summarize.
Lu
Yu-Ting
YT
Institute of Neuroscience, College of Medicine, Zhejiang University, Hangzhou 310058, China.
Zhu
Li-Jun
LJ
D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D004827:Epilepsy / Q000378:metabolism*; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D012559:Schizophrenia / Q000378:metabolism; D020521:Stroke / Q000378:metabolism
D002352:Carrier Proteins; D009687:Nuclear Proteins; C498297:PICk1 protein, human