[Hepatotoxicity of antineoplastic agents].
The influence of various antineoplastic preparations (farmorubicin, paclitaxel, etoposide, platidiam) on morphological and functional status of the liver in experimental animals was studied. It is shown, that all these antineoplastic drugs possess strong hepatotoxic activity and thereby cause toxic hepatitis and increase activity of hepatic enzymes. Biochemical parameters were normalized within 30 days after treatment whereas morphological changes persisted somewhat longer.
Karpova
G V
GV
Fomina
T I
TI
Vetoshkina
T V
TV
Dubskaia
T Iu
TIu
Ermolaeva
L A
LA
Churin
A A
AA
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051381:Rats; D012307:Risk Factors
D000970:Antineoplastic Agents