title: [Anti-ulcerative effect of non-starch polysaccharides].
abstract: Standard models of experimental ulceration (of neurogenic origin, H. Shay ulcer, indomethacine-, ethanol-, prednisolone-, histamine- and acetate-induced ulcers) were used to demonstrate protective effect of non-starch polysaccharides (potassium alginate, potassium pectate, low-esterified pectin). Potassium pectate proved to be the most efficacious protector. Mechanism of its anti-ulcerative action is attributable to antacidic, cytoprotective, and reparative activity. It appeals to optimally stimulate the motor-evacuation function and, besides, exhibits marked anti-inflammatory activity.
authors.forename: S G
authors.initials: SG
authors.lastname: Krylova
authors.forename: L A
authors.initials: LA
authors.lastname: Efimova
authors.forename: E P
authors.initials: EP
authors.lastname: Zueva
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Khotimchenko
authors.forename: T G
authors.initials: TG
authors.lastname: Razina
authors.forename: E N
authors.initials: EN
authors.lastname: Amosova
authors.forename: K A
authors.initials: KA
authors.lastname: Lopatina
authors.forename: T I
authors.initials: TI
authors.lastname: Fomina
mesh_terms: D000284:Administration, Oral; D000464:Alginates / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000930:Antidiarrheals / Q000008:administration & dosage / Q000627:therapeutic use; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004337:Drug Carriers; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D020723:Glucuronic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D006603:Hexuronic Acids / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D051379:Mice; D010368:Pectins / Q000008:administration & dosage / Q000627:therapeutic use*; D011134:Polysaccharides / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D000464:Alginates; D000930:Antidiarrheals; D001672:Biocompatible Materials; D004337:Drug Carriers; D006603:Hexuronic Acids; D011134:Polysaccharides; D010368:Pectins; D020723:Glucuronic Acid