title: Hyperlipidemia: a new therapeutic target for diabetic neuropathy.
abstract: Emerging data establish dyslipidemia as a significant contributor to the development of diabetic neuropathy. In this review, we discuss how separate metabolic imbalances, including hyperglycemia and hyperlipidemia, converge on mechanisms leading to oxidative stress in dorsal root ganglia (DRG) sensory neurons. We conclude with suggestions for novel therapeutic strategies to prevent or reverse diabetes-induced nerve degeneration.
authors.affiliation: Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA. andreav@umich.edu
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Vincent
authors.forename: Lucy M
authors.initials: LM
authors.lastname: Hinder
authors.forename: Rodica
authors.initials: R
authors.lastname: Pop-Busui
authors.forename: Eva L
authors.initials: EL
authors.lastname: Feldman
mesh_terms: D000818:Animals; D003929:Diabetic Neuropathies / Q000503:physiopathology* / Q000628:therapy*; D005727:Ganglia, Spinal / Q000503:physiopathology; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology / Q000628:therapy; D006949:Hyperlipidemias / Q000503:physiopathology* / Q000628:therapy*; D018384:Oxidative Stress / Q000502:physiology; D011984:Sensory Receptor Cells / Q000502:physiology