Oriented synthesis and in vitro anticancer activity of biquinazoline-2,2'-diones.
The synthesis of a series of biquinazoline-2,2'-diones starting from o-nitrobenzaldehydes, anilines, and triphosgene is presented. This general approach features a novel and easy way for access to the target products. The mechanistic course of the reaction suggests the involvement of reduction, coupling, and cyclization by one-pot. These compounds were also investigated in vitro for anticancer activity, and some were found to have good anticancer activity.
Dou
Guolan
G
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, PR China.
Shi
Daqing
D
Li
Yonghai
Y
D000814:Aniline Compounds / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D001547:Benzaldehydes / Q000737:chemistry; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008113:Liver Neoplasms / Q000188:drug therapy; D015394:Molecular Structure; D010705:Phosgene / Q000031:analogs & derivatives / Q000737:chemistry; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use
D000814:Aniline Compounds; D000970:Antineoplastic Agents; D001547:Benzaldehydes; D011799:Quinazolines; D010705:Phosgene; C111044:bis(trichloromethyl) carbonate; C043850:2-nitrobenzaldehyde; C023650:aniline