title: Primary malignant melanoma of the lung with rapid progression.
abstract: This report presents a case of primary malignant melanoma of the lung with rapid progression in a 68-year-old man. During a regular checkup, a chest roentgenogram revealed an abnormal shadow in the left lower lung field. Computed tomography (CT) of the chest revealed an ill-defined tumor shadow measuring 4 x 3 cm in the left upper lobe. A CT-guided lung biopsy suggested a large-cell carcinoma, and left upper lobectomy was performed. Histopathologically, the tumor was comprised of malignant epithelial tumor cells with large amounts of acidophilic cytoplasm and prominent nuclei. A dark brown pigment was observed in the tumor cells. Immunohistochemical staining was positive for S-100 protein and HMB45; staining for cytokeratin, CAM5.2, and chromogranin was negative. The final diagnosis was malignant melanoma of the lung. Two months later, multiple brain metastases developed, and he died of the disease 6 months after the surgery.
authors.affiliation: Matsue Red Cross Hospital, Horomachi, Shimane, Japan. ryomaedamatsue@yahoo.co.jp
authors.forename: Ryo
authors.initials: R
authors.lastname: Maeda
authors.forename: Noritaka
authors.initials: N
authors.lastname: Isowa
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Onuma
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miura
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tokuyasu
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kawasaki
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D001932:Brain Neoplasms / Q000556:secondary*; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D033162:Incidental Findings; D008175:Lung Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000737:chemistry / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary; D011013:Pneumonectomy; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor