title: Severe seizures associated with traumatic brain injury managed by controlled hypothermia, pharmacologic coma, and mechanical ventilation in a dog.
abstract: OBJECTIVE
  To describe the management and outcome of a dog presenting with intractable seizures associated with traumatic brain injury.
  
  
  METHODS
  A spayed female Wheaten Terrier was presented to an emergency clinic with neurologic deficits (modified Glasgow coma scale of 10) shortly after a road traffic accident. Seizures were uncontrolled despite aggressive pharmacologic intervention. Controlled hypothermia to achieve a rectal temperature of 33-35 degrees C (91.4-95 degrees F) was initiated as a protective measure to reduce intracranial pressure and cerebral metabolic rate, and to assist with seizure control. Intubation and mechanical ventilation were required to protect the airway and manage hypercapnia associated with hypoventilation. The patient went on to make a full recovery, although behavioral changes were noted by the owners for an 8-week period following injury.
  
  
  CONCLUSIONS
  To the author's knowledge, this is the first instance of therapeutic hypothermia reported in the veterinary literature. A short review of this treatment modality is provided.
authors.affiliation: Emergency Department, Western Veterinary Specialist Centre, Calgary, AB, Canada T3C 0J8. galina@uoguelph.ca
authors.forename: Galina M
authors.initials: GM
authors.lastname: Hayes
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000150:complications / Q000662:veterinary*; D003128:Coma / Q000662:veterinary; D004285:Dogs / Q000293:injuries*; D005260:Female; D015600:Glasgow Coma Scale / Q000662:veterinary; D007036:Hypothermia, Induced / Q000662:veterinary*; D012121:Respiration, Artificial / Q000662:veterinary; D012640:Seizures / Q000175:diagnosis / Q000209:etiology / Q000628:therapy / Q000662:veterinary*; D016896:Treatment Outcome