title: Mid-life blood pressure levels and the 8-year incidence of type 2 diabetes mellitus: the Rancho Bernardo Study.
abstract: Type 2 diabetes mellitus (T2DM) and hypertension frequently occur together. We examined whether blood pressure (BP) levels predict 8-year incident diabetes. Participants were community-dwelling older adults who had BP measured twice and an oral glucose tolerance test at baseline and again 8.3 years later. At baseline, participants were classified as normotensive (systolic blood pressure (SBP) <120 mm Hg and diastolic blood pressure (DBP) <80 mm Hg; n=242); prehypertensive (SBP>or=120 and <140 mm Hg or DBP>or=80 and <90 mm Hg; n=426); or hypertensive (SBP>or=140 mm Hg or DBP>or=90 mm Hg or using anti-hypertensive medication; n=457). There were 1125 participants (mean age 66.0 years; 44.3% men) who attended the baseline and follow-up visit, of whom 85 had new onset T2DM. Participants who developed T2DM had higher mean body mass index (BMI) and BP levels than those who did not develop diabetes. In logistic regression models adjusted for age, sex, BMI, and physical activity, the odds of incident T2DM was greater in prehypertensives (odds ratio (OR) 2.32 95% confidence interval (CI) 1.05-5.1, P=0.03) and hypertensives (OR 3.5 95% CI 1.50-8.0, P=0.002) compared with normotensives. Excluding participants who used anti-hypertensive medications did not change results. In conclusion, mid-life hypertension and prehypertension predicted future diabetes, independent of BMI. Glucose surveillance should be encouraged in adults with prehypertension or hypertension.
authors.affiliation: Division of Epidemiology, Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0607, USA.
authors.forename: C K
authors.initials: CK
authors.lastname: Kramer
authors.forename: D
authors.initials: D
authors.lastname: von Mühlen
authors.forename: E
authors.initials: E
authors.lastname: Barrett-Connor
mesh_terms: D017677:Age Distribution; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D002140:California / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology; D011237:Predictive Value of Tests; D012372:ROC Curve; D012307:Risk Factors