Rhodium-catalyzed asymmetric addition of arylboronic acids to beta-phthaliminoacrylate esters toward the synthesis of beta-amino acids.
Rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to beta-phthaliminoacrylate esters took place efficiently to give high yields of beta-aryl-beta-amino acid esters with 96-99% enantioselectivity, which was realized by use of a hydroxorhodium/chiral diene complex.
Nishimura
Takahiro
T
Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan. tnishi@kuchem.kyoto-u.ac.jp
Wang
Jun
J
Nagaosa
Makoto
M
Okamoto
Kazuhiro
K
Shintani
Ryo
R
Kwong
Fuk-yee
FY
Yu
Wing-yiu
WY
Chan
Albert S C
AS
Hayashi
Tamio
T
D000179:Acrylates / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010795:Phthalic Acids / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D000179:Acrylates; D000596:Amino Acids; D001897:Boronic Acids; D009942:Organometallic Compounds; D010795:Phthalic Acids; C547805:beta-phthaliminoacrylate ester; D012238:Rhodium