title: Seasonal influenza vaccine elicits heterosubtypic immunity against H5N1 that can be further boosted by H5N1 vaccination.
abstract: Recent findings indicate that seasonal influenza vaccination or infection of healthy humans may contribute to heterosubtypic immunity against new influenza A subtypes, such as H5N1. Here, we investigated whether seasonal influenza vaccination in a mouse model could induce any immunity against the H5N1 subtype. It could be demonstrated that, largely due to the H1N1 component strain A/NewCaledonia/20/99, parenteral immunization of mice with a trivalent seasonal influenza vaccine elicited heterosubtype H5-reactive antibodies able to confer partial protection against H5N1 influenza virus infection. Furthermore, the trivalent seasonal influenza vaccine was found to be compatible with a whole virus H5N1 vaccine in a heterologous prime-boost immunization regimen, achieving superior efficacy compared to a single immunization with an equivalent low-dose of the H5N1 vaccine.
authors.affiliation: Baxter Bioscience, Biomedical Research Centre, A-2304, Uferstrasse 15, Orth/Donau, Austria.
authors.forename: André
authors.initials: A
authors.lastname: van Maurik
authors.forename: Nicolas
authors.initials: N
authors.lastname: Sabarth
authors.forename: Helga Savidis
authors.initials: HS
authors.lastname: Dacho
authors.forename: Peter
authors.initials: P
authors.lastname: Brühl
authors.forename: Michael
authors.initials: M
authors.lastname: Schwendinger
authors.forename: Brian A
authors.initials: BA
authors.lastname: Crowe
authors.forename: P
authors.initials: P
authors.lastname: Noel Barrett
authors.forename: Otfried
authors.initials: O
authors.lastname: Kistner
authors.forename: M
authors.initials: M
authors.lastname: Keith Howard
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D000918:Antibody Specificity; D003429:Cross Reactions / Q000276:immunology; D005260:Female; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D007116:Immunization, Passive; D007117:Immunization, Secondary; D053124:Influenza A Virus, H5N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology; D015847:Interleukin-4 / Q000276:immunology; D051379:Mice; D009500:Neutralization Tests; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D015847:Interleukin-4; D007371:Interferon-gamma