Anti-infective antibodies--reviving an old paradigm.
Antibody therapy for infections has a long history and the development of monoclonal antibody technologies, and of increasingly ingenious techniques for making these products, has brought about a major revival in interest. In this paper the field is reviewed with particular emphasis on two topics: the role that antibodies may have in combating pandemic flu; and the prospects for giving, as a food, antibodies derived from the ovalbumin of transgenic chicken eggs, as a prophylactic against diarrhoeal disease.
Lachmann
Peter
P
Emeritus Sheila Joan Smith Professor of Immunology, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom. pjl1000@cam.ac.uk
D000818:Animals; D030801:Animals, Genetically Modified; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002645:Chickens; D003967:Diarrhea / Q000517:prevention & control*; D004196:Disease Outbreaks / Q000517:prevention & control; D004531:Eggs; D006801:Humans; D007116:Immunization, Passive; D007251:Influenza, Human / Q000517:prevention & control*
D000911:Antibodies, Monoclonal