title: Development of the RTS,S/AS malaria candidate vaccine.
abstract: A vaccine against malaria which complements existing control tools is an urgent medical need. RTS,S/AS, a pre-erythrocytic candidate vaccine, which targets the circumsporozoite protein, is the most advanced in clinical development. The safety, immunogenicity and efficacy of this candidate vaccine have been investigated in a series of trials in children and infants in endemic African countries. The vaccine shows promise for providing important public health benefits and a multicenter Phase III trial has started in Africa, aiming to further characterize the efficacy of the candidate vaccine and generate the regulatory data required for the licensing approval of the vaccine.
authors.affiliation: GlaxoSmithKline Biologicals, 89 rue de l'Institut, 1330 Rixensart, Belgium. johan.vekemans@gskbio.com
authors.forename: Johan
authors.initials: J
authors.lastname: Vekemans
authors.forename: Amanda
authors.initials: A
authors.lastname: Leach
authors.forename: Joe
authors.initials: J
authors.lastname: Cohen
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D017780:Malaria Vaccines / Q000276:immunology*; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000276:immunology; D015800:Protozoan Proteins / Q000276:immunology
chemical_list: D017780:Malaria Vaccines; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan