title: Anti-inflammatory and immunomodulatory effects of Ulomoides dermestoides on induced pleurisy in rats and lymphoproliferation in vitro.
abstract: The following study aimed to evaluate, in vitro and in vivo, the anti-inflammatory effect of Ulomoides dermestoides, a beetle commonly used as a remedy for a variety of diseases including respiratory disorders and asthma. We used an acute inflammation model of injury, injection of carrageenan into the pleural cavity of rats. The rats were treated intraperitoneally with the aqueous extract of U. dermestoides 8 and 16 mg/kg. The exudate volume, protein concentration, polymorphonuclear leukocytes (PMNs) and total leukocyte were measured. The peripheral blood mononuclear cells (PBMCs) were isolated from the blood of healthy subjects and we investigated the immunomodulatory and cytotoxic effect of aqueous extract of U. dermestoides. In conclusion, in vitro we observed a non-cytotoxic effect and antiproliferative activity on the dose of 12.5 mg/dL. In vivo, this paper clarifies the great clinical relevance of the aqueous extract of U. dermestoides in elucidating its role as an anti-inflammatory agent.
authors.affiliation: Laboratório de Microbiologia Clínica, Centro Universitário Franciscano (UNIFRA), Santa Maria, Rio Grande do Sul, Brasil.
authors.forename: Roberto Christ Vianna
authors.initials: RC
authors.lastname: Santos
authors.forename: Adroaldo
authors.initials: A
authors.lastname: Lunardelli
authors.forename: Eduardo
authors.initials: E
authors.lastname: Caberlon
authors.forename: Carolina Maria Alves
authors.initials: CM
authors.lastname: Bastos
authors.forename: Fernanda Bordignon
authors.initials: FB
authors.lastname: Nunes
authors.forename: Melissa Guerra Simões
authors.initials: MG
authors.lastname: Pires
authors.forename: Vanderlei
authors.initials: V
authors.lastname: Biolchi
authors.forename: Elisiane Lozza
authors.initials: EL
authors.lastname: Paul
authors.forename: Francesco Breno Campolongo
authors.initials: FB
authors.lastname: Vieira
authors.forename: Alzira
authors.initials: A
authors.lastname: Resende do Carmo Aquino
authors.forename: Elio
authors.initials: E
authors.lastname: Corseuil
authors.forename: Jarbas Rodrigues
authors.initials: JR
authors.lastname: de Oliveira
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001938:Brazil; D002351:Carrageenan / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects / Q000276:immunology; D002478:Cells, Cultured; D001517:Coleoptera; D045424:Complex Mixtures / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005122:Exudates and Transudates / Q000276:immunology; D005260:Female; D019476:Insect Proteins / Q000276:immunology / Q000494:pharmacology*; D008519:Medicine, Traditional; D010998:Pleurisy / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D045424:Complex Mixtures; D019476:Insect Proteins; D002351:Carrageenan