title: Cytotoxicity and biocompatibility of direct and indirect pulp capping materials.
abstract: There are several studies about the cytotoxic effects of dental materials in contact with the pulp tissue, such as calcium hydroxide (CH), adhesive systems, resin composite and glass ionomer cements. The aim of this review article was to summarize and discuss the cytotoxicity and biocompatibility of materials used for protection of the dentin-pulp complex, some components of resin composites and adhesive systems when placed in direct or indirect contact with the pulp tissue. A large number of dental materials present cytotoxic effects when applied close or directly to the pulp, and the only material that seems to stimulate early pulp repair and dentin hard tissue barrier formation is CH.
authors.affiliation: Department of Operative Dentistry, Endodontics and Dental Materials, University of São Paulo, Bauru, Brazil.
authors.forename: Karin Cristina da Silva
authors.initials: KC
authors.lastname: Modena
authors.forename: Leslie Caroll
authors.initials: LC
authors.lastname: Casas-Apayco
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Atta
authors.forename: Carlos Alberto de Souza
authors.initials: CA
authors.lastname: Costa
authors.forename: Josimeri
authors.initials: J
authors.lastname: Hebling
authors.forename: Carla Renata
authors.initials: CR
authors.lastname: Sipert
authors.forename: Maria Fidela de Lima
authors.initials: MF
authors.lastname: Navarro
authors.forename: Carlos Ferreira
authors.initials: CF
authors.lastname: Santos
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000633:toxicity*; D003738:Dental Cements / Q000737:chemistry / Q000633:toxicity; D003764:Dental Materials / Q000737:chemistry / Q000633:toxicity*; D003782:Dental Pulp / Q000187:drug effects*; D003785:Dental Pulp Capping; D003804:Dentin / Q000187:drug effects; D006801:Humans
chemical_list: D001672:Biocompatible Materials; D003738:Dental Cements; D003764:Dental Materials