Identification of two novel variants in PRKAG2 gene in Tunisian type 2 diabetic patients with family history of cardiovascular disease.
We report the identification of two novel polymorphisms in the PRKAG2 gene and preliminary association study between 5'-UTR and exon 1 polymorphisms with susceptibility to type 2 diabetes. No association with type 2 diabetes was identified. However, one of these newly identified polymorphisms (p.Ser20Ile) is likely associated with cardiac disease.
Nouira
S
S
Institut Pasteur de Tunis, Tunisia.
Arfa
I
I
Kammoun
I
I
Abid
A
A
Ouragini
H
H
Dorboz
I
I
Ghazouani
W
W
Fadhel
S Ben
SB
Zorgati
M M
MM
Ammar
S Ben
SB
Blousa-Chabchoub
S
S
Kachboura
S
S
Abdelhak
S
S
D020121:5' Untranslated Regions / Q000235:genetics; D055372:AMP-Activated Protein Kinases / Q000235:genetics*; D017668:Age of Onset; D000368:Aged; D001483:Base Sequence; D002318:Cardiovascular Diseases / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D003925:Diabetic Angiopathies / Q000235:genetics*; D005091:Exons / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D008487:Medical History Taking; D008875:Middle Aged; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D012016:Reference Values; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D014416:Tunisia
D020121:5' Untranslated Regions; C526223:PRKAG2 protein, human; D055372:AMP-Activated Protein Kinases