Prognostic value of anti-cyclic citrullinated peptide antibodies and rheumatoid factor in patients with rheumatoid arthritis.
OBJECTIVE
To determine the predictive value for radiological damage of anti-cyclic citrullinated peptide antibodies (anti-CCP) and rheumatoid factor (RF) in patients with rheumatoid arthritis (RA).


METHODS
Ninety patients with RA were enrolled in this study. All patients had symptom duration of at least one year. Anti-CCP and IgM-RF were evaluated with enzyme linked immunosorbent assay and nephelometry methods, respectively. Radiological damage was assessed by Larsen score.


RESULTS
In forward stepwise logistic regression analysis, anti-CCP positivity and RF positivity were seen as significant independent predictors of the radiological outcomes (p = 0.01, p < 0.05, respectively). The combination of these antibodies had the highest risk for erosive joint damage (odds ratio = 25.71; 95% confidence interval, 4.7 to 140.13; p = 0.001).


CONCLUSIONS
Our results suggest that the combined use of RF and anti-CCP has greater predictive value for erosive RA than anti-CCP or RF alone, and may facilitate to make a decision about the individual treatment in RA (Tab. 4, Ref. 37). Full Text (Free, PDF) www.bmj.sk.
Kuru
Omer
O
Ondokuz Mayis University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Samsun, Turkey.
Bilgici
Ayhan
A
Birinci
Asuman
A
Ulusoy
Hasan
H
Durupinar
Belma
B
D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D001323:Autoantibodies / Q000097:blood*; D005384:Finger Joint / Q000000981:diagnostic imaging; D006801:Humans; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*; D011379:Prognosis; D011859:Radiography; D012217:Rheumatoid Factor / Q000097:blood*; D012680:Sensitivity and Specificity
D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor