title: The impact of nutritional deficit on mortality of in-patients with pulmonary tuberculosis.
abstract: METHODS
  A metropolitan governmental medical centre, Seoul, Republic of Korea.
  
  
  OBJECTIVE
  To elucidate the impact of the nutritional deficit assessed by the Nutritional Risk Score (NRS) on the outcomes of in-patients with pulmonary tuberculosis (PTB).
  
  
  METHODS
  All hospitalised patients with microbiologically confirmed PTB were enrolled. A four-point NRS included low body mass index (<18.5 kg/m(2)), hypoalbuminaemia (<30.0 g/l), hypocholesterolaemia (<2.33 mmol/l) and severe lymphocytopaenia (<7 x 10(5) cells/l). The primary outcome was overall in-hospital mortality. The degree of radiographical resolution after anti-tuberculosis treatment was also evaluated.
  
  
  RESULTS
  In a total of 156 patients, the male to female ratio was 1.6:1. The overall mortality was 13.5% and tuberculosis-specific fatality was 3.9%. Predisposing factors and high NRS (> or = 3 points) were independent risk factors for in-hospital death after adjusting for the severity of PTB. High NRS (OR = 16.8, P < 0.001) and predisposing factors (OR = 5.4, P = 0.032) were independent risk factors for 30-day survival. The NRS was not associated with radiographic improvement.
  
  
  CONCLUSIONS
  Regardless of disease severity, the high NRS was a significant negative predictor among in-patients with PTB; this finding should therefore be considered in the management of PTB despite the current era of effective anti-tuberculosis chemotherapy.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Kim
authors.forename: C-H
authors.initials: CH
authors.lastname: Lee
authors.forename: S
authors.initials: S
authors.lastname: Shin
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
authors.forename: Y W
authors.initials: YW
authors.lastname: Kim
authors.forename: H S
authors.initials: HS
authors.lastname: Chung
authors.forename: S K
authors.initials: SK
authors.lastname: Han
authors.forename: Y-S
authors.initials: YS
authors.lastname: Shim
authors.forename: D K
authors.initials: DK
authors.lastname: Kim
mesh_terms: D000046:Academic Medical Centers / Q000706:statistics & numerical data; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007297:Inpatients / Q000706:statistics & numerical data; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009748:Nutrition Disorders / Q000150:complications*; D011859:Radiography; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality*