[The value of TNFalpha testing in evaluation of death due to drug anaphylactic shock].
OBJECTIVE
To analyze the changes of the serum TNFalpha level in cadavers of drug anaphylactic shock(DAS) and to explore the significance of the TNFalpha testing in evaluation of death caused by DAS.


METHODS
The level of serum TNFalpha from cardiac blood was determined by double antibody-sandwich ELISA method.


RESULTS
The level of TNFalpha in the experimental group was (131.6+/-9.4) pg/mL, while the level in the infectious diseases control group and the normal control group were (87.3+/-6.4) pg/mL and (17.2+/-4.5) pg/mL, respectively. There was statistically significant difference among the groups (P<0.05).


CONCLUSIONS
The serum TNFalpha level may be used as one of the indexes for evaluation of death caused by highly suspected drug anaphylactic shock.
Hu
Yong-Liang
YL
The Third Department of Medicine, Wannan Medical College, Wuhu, China. wanyi.hu@163.com
Zhu
Jian-Hua
JH
Jing
Hua-Lan
HL
D000293:Adolescent; D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000097:blood* / Q000473:pathology; D001344:Autopsy; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D004342:Drug Hypersensitivity; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D049429:Forensic Pathology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D055815:Young Adult
D014409:Tumor Necrosis Factor-alpha