title: Synthesis and SAR of sulfonyl- and phosphoryl amidine compounds as anti-resorptive agents.
abstract: Sulfonyl amidines (1) and phosphoryl amidines (2), which were efficiently synthesized via a Cu-catalyzed one pot reaction, showed potent anti-bone resorptive activity in vitro. Structure activity relationship studies led to the identification of numerous osteoclast differentiation inhibitors.
authors.affiliation: Department of Chemistry and Medical Chemistry, Yonsei University, Wonju 220-710, Republic of Korea.
authors.forename: Myung Yun
authors.initials: MY
authors.lastname: Lee
authors.forename: Myung Hee
authors.initials: MH
authors.lastname: Kim
authors.forename: Jinho
authors.initials: J
authors.lastname: Kim
authors.forename: Seok Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Bum Tae
authors.initials: BT
authors.lastname: Kim
authors.forename: In Howa
authors.initials: IH
authors.lastname: Jeong
authors.forename: Sukbok
authors.initials: S
authors.lastname: Chang
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Sung-Youn
authors.initials: SY
authors.lastname: Chang
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000578:Amidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D007527:Isoenzymes / Q000378:metabolism; D051379:Mice; D063065:Organophosphonates / Q000737:chemistry*; D010010:Osteoclasts / Q000187:drug effects; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000737:chemistry*; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D000578:Amidines; D007527:Isoenzymes; D063065:Organophosphonates; D013450:Sulfones; D003300:Copper; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase