Novel metabolic pathway for salicylate biodegradation via phenol in yeast Trichosporon moniliiforme.
A novel metabolic pathway was found in the yeast Trichosporon moniliiforme WU-0401 for salicylate degradation via phenol as the key intermediate. When 20 mM salicylate was used as the sole carbon source for the growth of strain WU-0401, phenol was detected as a distinct metabolite in the culture broth. Analysis of the products derived from salicylate or phenol through reactions with resting cells and a cell-free extract of strain WU-0401 indicated that salicylate is initially decarboxylated to phenol and then oxidized to catechol, followed by aromatic ring cleavage to form cis-cis muconate.
Iwasaki
Yuichiro
Y
Faculty of Science and Engineering, Department of Applied Chemistry, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo, 169-8555, Japan.
Gunji
Hiroaki
H
Kino
Kuniki
K
Hattori
Takasumi
T
Ishii
Yoshitaka
Y
Kirimura
Kohtaro
K
D001673:Biodegradation, Environmental; D010084:Oxidation-Reduction; D019800:Phenol / Q000378:metabolism*; D020156:Salicylic Acid / Q000378:metabolism*; D014250:Trichosporon / Q000378:metabolism*
D019800:Phenol; D020156:Salicylic Acid