Detecting interacting genetic loci with effects on quantitative traits where the nature and order of the interaction are unknown.
Standard techniques for single marker quantitative trait mapping perform poorly in detecting complex interacting genetic influences. When a genetic marker interacts with other genetic markers and/or environmental factors to influence a quantitative trait, a sample of individuals will show different effects according to their exposure to other interacting factors. This paper presents a Bayesian mixture model, which effectively models heterogeneous genetic effects apparent at a single marker. We compute approximate Bayes factors which provide an efficient strategy for screening genetic markers (genome-wide) for evidence of a heterogeneous effect on a quantitative trait. We present a simulation study which demonstrates that the approximation is good and provide a real data example which identifies a population-specific genetic effect on gene expression in the HapMap CEU and YRI populations. We advocate the use of the model as a strategy for identifying candidate interacting markers without any knowledge of the nature or order of the interaction. The source of heterogeneity can be modeled as an extension.
Davies
Joanna L
JL
Department of Statistics, University of Oxford, 1 South Parks Road, Oxford, United Kingdom. davies@stats.ox.ac.uk
Hein
Jotun
J
Holmes
Chris C
CC
D000465:Algorithms; D000483:Alleles; D001499:Bayes Theorem; D003198:Computer Simulation; D004777:Environment; D056426:Genetic Loci; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D016017:Odds Ratio; D040641:Quantitative Trait Loci; D012984:Software
D005819:Genetic Markers