Insulin-like growth factor I signaling in skeletal muscle and the potential for cytokine interactions.
Recent research has demonstrated that intracellular signaling components associated with several proinflammatory cytokines have the potential to interact with signaling pathways that regulate anabolic processes in skeletal muscle. This presentation and the ensuing brief review are intended to present a selection of the potential interactions between these two critical processes.
Adams
Gregory R
GR
Department of Physiology and Biophysics, University of California, Irvine, CA 92697-4560, USA. gradams@uci.edu
D000222:Adaptation, Physiological; D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D018482:Muscle, Skeletal / Q000254:growth & development / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D020239:Receptor Cross-Talk / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D058570:TOR Serine-Threonine Kinases
D016207:Cytokines; D047908:Intracellular Signaling Peptides and Proteins; D007334:Insulin-Like Growth Factor I; C546842:MTOR protein, human; D017346:Protein Serine-Threonine Kinases; D058570:TOR Serine-Threonine Kinases; D048049:Extracellular Signal-Regulated MAP Kinases