Circulating miRNA and cancer diagnosis.
miRNAs are a class of small RNA molecules with regulatory function, and play an important role in tumor development and progression. It has been demonstrated that tumor-derived miRNAs exist in the circulating nucleic acids of cancer patients. This phenomenon implies that detection of the circulating miRNA may be an effective method for non-invasive diagnosis of cancer. In this review, we summarize the applications of the circulating miRNA as biomarkers in cancer diagnosis, as well as the latest research progress in this area.
Tie
Yi
Y
Beijing Institute of Radiation Medicine, Bejing, China.
Liu
BinDong
B
Fu
HanJiang
H
Zheng
XiaoFei
X
D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor; D035683:MicroRNAs