title: CD137 promotes proliferation and survival of human B cells.
abstract: CD137 (4-1BB)-mediated costimulation plays an important role in directing the fate of Ag-stimulated T cells and NK cells, yet the role of CD137 in mediating B cell function is unknown. We found that CD137 is expressed in vitro on anti-Ig-stimulated peripheral blood B cells and in vivo on tonsillar B cells with an activated phenotype. In vitro CD137 expression is enhanced by CD40 stimulation and IFN-gamma and is inhibited by IL-4, -10, and -21. The expression of CD137 on activated human B cells is functionally relevant because engagement with its ligand at the time of activation stimulates B cell proliferation, enhances B cell survival, and induces secretion of TNF-alpha and -beta. Our study suggests that CD137 costimulation may play a role in defining the fate of Ag-stimulated human B cells.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA. xzhang@smail.umaryland.edu
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Zhang
authors.forename: Caroline J
authors.initials: CJ
authors.lastname: Voskens
authors.forename: Michelle
authors.initials: M
authors.lastname: Sallin
authors.forename: Amudhan
authors.initials: A
authors.lastname: Maniar
authors.forename: Carolina L
authors.initials: CL
authors.lastname: Montes
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Lin
authors.forename: Guoyan
authors.initials: G
authors.lastname: Li
authors.forename: Erin
authors.initials: E
authors.lastname: Burch
authors.forename: Ming
authors.initials: M
authors.lastname: Tan
authors.forename: Ronna
authors.initials: R
authors.lastname: Hertzano
authors.forename: Andrei I
authors.initials: AI
authors.lastname: Chapoval
authors.forename: Koji
authors.initials: K
authors.lastname: Tamada
authors.forename: Brian R
authors.initials: BR
authors.lastname: Gastman
authors.forename: Dan H
authors.initials: DH
authors.lastname: Schulze
authors.forename: Scott E
authors.initials: SE
authors.lastname: Strome
mesh_terms: D000941:Antigens / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D001773:Blood Cells; D019013:CD40 Antigens; D049109:Cell Proliferation; D002470:Cell Survival; D006801:Humans; D007378:Interleukins; D008213:Lymphocyte Activation; D008233:Lymphotoxin-alpha / Q000378:metabolism; D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9 / Q000819:agonists / Q000037:antagonists & inhibitors / Q000276:immunology / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000941:Antigens; D019013:CD40 Antigens; D007378:Interleukins; D008233:Lymphotoxin-alpha; D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9; D014409:Tumor Necrosis Factor-alpha