Processing of limb kinematics in the interpositus nucleus.
Neural representations of limb movement kinematic parameters are common among central nervous system structures involved in motor control, such as the interpositus nucleus of the cerebellum. Much experimental evidence indicates that neurons in the interpositus may encode limb kinematic parameters both during active, voluntary actions and during limb motion imposed passively, which entrains only sensory afferents. With respect to the sensory processing of information related to movement kinematics, we show that interpositus neuronal activity can parse out the directional from the scalar component (i.e., the movement speed) of the velocity vector. Moreover, a differential role for the anterior and posterior portion of interpositus in encoding these parameters emerged from these data, since the activity of the posterior interpositus was specifically associated to changes of movement speed. Limb movement representations in the interpositus nucleus may be instrumental for the control of goal-directed movements such as shaping hand during grasping or precise foot placement during gait. Finally, we discuss the idea that sensory information about the movement kinematics contribute to both feedback and anticipatory processes for limb movement control.
Casabona
Antonino
A
Department of Physiological Sciences, University of Catania, viale Andrea Doria 6, Catania, Italy.
Bosco
Gianfranco
G
Perciavalle
Vincenzo
V
Valle
Maria Stella
MS
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001696:Biomechanical Phenomena / Q000502:physiology*; D002529:Cerebellar Nuclei / Q000502:physiology*; D005121:Extremities / Q000294:innervation / Q000502:physiology*; D056228:Feedback, Sensory / Q000502:physiology; D006801:Humans; D009068:Movement / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology