Enantioselective Ag-Catalyzed Allylation of Aldimines.
A highly enantioselective synthesis of homoallylic amines, using allyltrimethoxysilane under Ag(I) catalytic conditions, has been developed. Among the chiral ligands investigated, a remarkable difference in the resulting Ag(I) complexes was observed. Under mild conditions and low catalyst loadings, homoallylamines were produced in high ee values (up to 80%) and good yields. The methodology can be further extended to a diastere- and enantioselective crotylation of aldimines.
Naodovic
Marina
M
Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA.
Wadamoto
Manabu
M
Yamamoto
Hisashi
H