[Anti-ulcerative effect of non-starch polysaccharides].
Standard models of experimental ulceration (of neurogenic origin, H. Shay ulcer, indomethacine-, ethanol-, prednisolone-, histamine- and acetate-induced ulcers) were used to demonstrate protective effect of non-starch polysaccharides (potassium alginate, potassium pectate, low-esterified pectin). Potassium pectate proved to be the most efficacious protector. Mechanism of its anti-ulcerative action is attributable to antacidic, cytoprotective, and reparative activity. It appeals to optimally stimulate the motor-evacuation function and, besides, exhibits marked anti-inflammatory activity.
Krylova
S G
SG
Efimova
L A
LA
Zueva
E P
EP
Khotimchenko
Iu S
IuS
Razina
T G
TG
Amosova
E N
EN
Lopatina
K A
KA
Fomina
T I
TI
D000284:Administration, Oral; D000464:Alginates / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000930:Antidiarrheals / Q000008:administration & dosage / Q000627:therapeutic use; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004337:Drug Carriers; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D020723:Glucuronic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D006603:Hexuronic Acids / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D051379:Mice; D010368:Pectins / Q000008:administration & dosage / Q000627:therapeutic use*; D011134:Polysaccharides / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
D000464:Alginates; D000930:Antidiarrheals; D001672:Biocompatible Materials; D004337:Drug Carriers; D006603:Hexuronic Acids; D011134:Polysaccharides; D010368:Pectins; D020723:Glucuronic Acid