Transmitting the message: intracellular mRNA localization.
The intracellular localization of mRNA is an important mechanism for targeting proteins to their sites of function. Localized transcripts play key roles ranging from body axis determination to synapse plasticity, and recent studies highlight how common localized transcripts are in a variety of model organisms. In this review, we consider the full range of known mechanisms for delivering transcripts and anchoring them at their site of function. Finally, we evaluate the progress that has been made in the nervous system in understanding the mechanism and function of mRNA localization and translation regulation.
Meignin
Carine
C
Department of Biochemistry, New Biochemistry Building, The University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
Davis
Ilan
I
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D012333:RNA, Messenger