title: Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents.
abstract: This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.
authors.affiliation: Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan.
authors.forename: Wen-Shan
authors.initials: WS
authors.lastname: Li
authors.forename: Shivaji V
authors.initials: SV
authors.lastname: More
authors.forename: Chie-Hong
authors.initials: CH
authors.lastname: Wang
authors.forename: Ya Ching
authors.initials: YC
authors.lastname: Jen
authors.forename: Ching-Fa
authors.initials: CF
authors.lastname: Yao
authors.forename: Tein-Fu
authors.initials: TF
authors.lastname: Wang
authors.forename: Chin-Chun
authors.initials: CC
authors.lastname: Hung
authors.forename: Shu-Chuan
authors.initials: SC
authors.lastname: Jao
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003958:Diamide / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000627:therapeutic use; D005663:Furans / Q000138:chemical synthesis* / Q000627:therapeutic use; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; D003958:Diamide