title: [Identification of susceptibility genes for age-related macular degeneration--a success story of molecular genetics].
abstract: The number of persons over 70 years of age with advanced age-related macular degeneration in Finland can be estimated to be approximately 50,000. Milder forms are additionally present in a considerably larger group. Smoking and age are undisputed non-genetic risk factors of age-related macular degeneration. Of the genetic factors, polymorphisms of the complement factor H (CFH) and LOC387715 genes have a strong impact on the risk of developing the disease, whereas alleles of the C3, CFB, and the C1 inhibitor SERPING1 genes of the complement system exhibit only minor effects.
authors.affiliation: HUS:n silmäsairaala, Haartmaninkatu 2, 00290 Helsinki, ja Helsingin yliopisto, Biomedicum, lääketieteellisen, genetiikan osasto.
authors.forename: Sanna
authors.initials: S
authors.lastname: Seitsonen
authors.forename: Päivi
authors.initials: P
authors.lastname: Onkamo
authors.forename: Ilkka
authors.initials: I
authors.lastname: Immonen
authors.forename: Irma
authors.initials: I
authors.lastname: Järvelä
mesh_terms: D003174:Complement C1 Inactivator Proteins / Q000235:genetics; D050718:Complement C1 Inhibitor Protein; D017242:Complement Factor H / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D003174:Complement C1 Inactivator Proteins; D050718:Complement C1 Inhibitor Protein; C469952:SERPING1 protein, human; D017242:Complement Factor H