title: A new miniaturized system for extracorporeal membrane oxygenation in adult respiratory failure.
abstract: BACKGROUND
  Mortality of severe acute respiratory distress syndrome in adults is still unacceptably high. Extracorporeal membrane oxygenation (ECMO) could represent an important treatment option, if complications were reduced by new technical developments.
  
  
  METHODS
  Efficiency, side effects and outcome of treatment with a new miniaturized device for veno-venous extracorporeal gas transfer were analysed in 60 consecutive patients with life-threatening respiratory failure.
  
  
  RESULTS
  A rapid increase of partial pressure of arterial oxygen/fraction of inspired oxygen (PaO2/FiO2) from 64 (48 to 86) mmHg to 120 (84 to 171) mmHg and a decrease of PaCO2 from 63 (50 to 80) mmHg to 33 (29 to 39) mmHg were observed after start of the extracorporeal support (P < 0.001). Gas exchange capacity of the device averaged 155 (116 to 182) mL/min for oxygen and 210 (164 to 251) mL/min for carbon dioxide. Ventilatory parameters were reduced to a highly protective mode, allowing a fast reduction of tidal volume from 495 (401 to 570) mL to 336 (292 to 404) mL (P < 0.001) and of peak inspiratory pressure from 36 (32 to 40) cmH2O to 31 (28 to 35) cmH2O (P < 0.001). Transfusion requirements averaged 0.8 (0.4 to 1.8) units of red blood cells per day. Sixty-two percent of patients were weaned from the extracorporeal system, and 45% survived to discharge.
  
  
  CONCLUSIONS
  Veno-venous extracorporeal membrane oxygenation with a new miniaturized device supports gas transfer effectively, allows for highly protective ventilation and is very reliable. Modern ECMO technology extends treatment opportunities in severe lung failure.
authors.affiliation: Department of Medicine II, University Hospital Regensburg, 93053 Regensburg, Germany. thomas.mueller@klinik.uni-regensburg.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Müller
authors.forename: Alois
authors.initials: A
authors.lastname: Philipp
authors.forename: Andreas
authors.initials: A
authors.lastname: Luchner
authors.forename: Christian
authors.initials: C
authors.lastname: Karagiannidis
authors.forename: Thomas
authors.initials: T
authors.lastname: Bein
authors.forename: Michael
authors.initials: M
authors.lastname: Hilker
authors.forename: Leopold
authors.initials: L
authors.lastname: Rupprecht
authors.forename: Julia
authors.initials: J
authors.lastname: Langgartner
authors.forename: Markus
authors.initials: M
authors.lastname: Zimmermann
authors.forename: Matthias
authors.initials: M
authors.lastname: Arlt
authors.forename: Jan
authors.initials: J
authors.lastname: Wenger
authors.forename: Christof
authors.initials: C
authors.lastname: Schmid
authors.forename: Günter Aj
authors.initials: GA
authors.lastname: Riegger
authors.forename: Michael
authors.initials: M
authors.lastname: Pfeifer
authors.forename: Matthias
authors.initials: M
authors.lastname: Lubnow
mesh_terms: D000328:Adult; D000368:Aged; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008904:Miniaturization / Q000379:methods; D011014:Pneumonia / Q000150:complications; D011015:Pneumonia, Aspiration / Q000150:complications; D011175:Positive-Pressure Respiration; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy*; D018805:Sepsis / Q000150:complications; D013990:Tidal Volume; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000150:complications