Detecting population stratification using related individuals.
Although identification of cryptic population stratification is necessary for case/control association analyses, it is also vital for linkage analyses and family-based association tests when founder genotypes are missing. However, including related individuals in an analysis such as EIGENSTRAT can result in bias; using only founders or one individual per pedigree results in loss of data and inaccurate estimates of stratification. We examine a generalization of principal-component analyses to allow for the inclusion of related individuals by down-weighting the significance of individual comparisons.
Hinrichs
Anthony L
AL
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Campus Box 8134, St, Louis, Missouri 63110 USA. tony@silver.wustl.edu.
Culverhouse
Robert
R
Jin
Carol H
CH
Suarez
Brian K
BK