Mucous membrane grafting for lid margin keratinization in Stevens–Johnson syndrome: results.
OBJECTIVE
To study the efficacy of mucous membrane grafting asa surgical technique to address lid margin keratinization, an important cause for chronic blink-related microtrauma in Stevens–Johnson syndrome (SJS).


METHODS
The keratinized strip of conjunctiva along the lid margin was excised and replaced by lip mucous membrane using fibrin glue in 54 eyes of 31 patients with lid margin keratinization after SJS. This was a retrospective case series carried out between April 2005 and November 2006.


RESULTS
In 50 of 54 eyes (92.6%), there was improvement or stabilization in patient comfort, conjunctival hyperemia, ocular surface staining characteristics, and best-corrected visual acuity over a mean follow-up period of 6 months.


CONCLUSIONS
The authors describe the method of mucous membrane grafting for addressing lid margin keratinization, one of the important causes for persistent inflammation in SJS. This procedure not only improves patient comfort and visual acuity by reducing surface inflammation but also possibly prevents further deterioration of ocular surface in SJS.
Iyer
Geetha
G
Medical and Vision Research Foundation, Chennai, Tamil Nadu, India.  drgki@snmail.org
Pillai
Vinay S
VS
Srinivasan
Bhaskar
B
Guruswami
Sitalakshmi
S
Padmanabhan
Prema
P
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003229:Conjunctival Diseases / Q000601:surgery*; D005141:Eyelid Diseases / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000637:transplantation*; D009092:Mucous Membrane / Q000601:surgery; D012189:Retrospective Studies; D013262:Stevens-Johnson Syndrome / Q000601:surgery*; D014792:Visual Acuity; D055815:Young Adult