Carcinoma of the nasal cavity and paranasal sinuses in Denmark 1995-2004.
OBJECTIVE
To evaluate the treatment outcome for sino-nasal carcinomas in Denmark from 1995-2004 and compare the results to the previous Danish survey covering 1982-1991.


METHODS
Retrospective follow-up.


METHODS
In the five Danish head and neck oncology centres, charts of all consecutive patients with sino-nasal carcinomas were reviewed and data extracted to a common database. Altogether 242 patients from the period 1995-2004 were identified. Of these 162 (67%) were male and 80 (33%) female. Histologies included squamous cell carcinoma (55%), adenocarcinoma (28.5%), adenoid-cystic carcinoma (5.0%), undifferentiated carcinoma (4.5%), transitiocellular carcinoma (1.7%), mucoepidermoid carcinoma (0.8%), neuroendocrine carcinoma (2.5%), small cell carcinomas (1.2%) and carcinomas not otherwise specified (0.8%). Treatments included radiotherapy alone 79 (33%), surgery alone 29 (12%), combined surgery and radiotherapy 96 (40%), palliative/no treatment 38 (16%). A total of 204 (86%) patients were treated with curative intent.


RESULTS
Of the 204 patients treated with curative intent, 94 (46%) relapsed. Most failures were in T-site (63, 30%). N-site failures were 10 (5%) and M-site failures six (3%). Failure occurring in T+N-site, T+M-site, N+M-site and T+N+M-site were seven (3%), two (1%), one (0.5%) and five (3%) respectively. The 5-year actuarial local, nodal and loco-regional control rates were 55 + or - 4%, 86 + or - 3%, 49 + or - 4%, respectively. The overall 5-year actuarial survival rate for the entire cohort was 47 + or - 3%, and the corresponding cancer-specific 5-year actuarial survival rate was 57 + or - 3%. Female gender, nasal cavity tumour, adenocarcinoma and low clinical stage were significant positive prognostic factors in univariate analysis. A Cox multivariate analysis showed that only tumour site and clinical stage were independent significant prognostic factors.


CONCLUSIONS
The current series has confirmed stage and tumour site as independent prognostic factors. Compared to the previous Danish survey covering the period 1982-1991, the overall survival and cancer-specific survival rates have improved significantly.
Thorup
Christian
C
Department of Oncology, Aarhus University Hospital, Aarhus, Denmark. christianthorup@dadlnet.dk
Sebbesen
Lars
L
Danø
Hella
H
Leetmaa
Michael
M
Andersen
M
M
Buchwald
Christian
C
Kristensen
Claus A
CA
Bentzen
Jens
J
Godballe
Christian
C
Johansen
Jørgen
J
Grau
Cai
C
D000230:Adenocarcinoma / Q000453:epidemiology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000453:epidemiology* / Q000473:pathology; D018277:Carcinoma, Mucoepidermoid / Q000453:epidemiology; D018278:Carcinoma, Neuroendocrine / Q000453:epidemiology; D018288:Carcinoma, Small Cell / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology; D002295:Carcinoma, Transitional Cell / Q000453:epidemiology; D003536:Cystadenocarcinoma / Q000453:epidemiology; D003718:Denmark / Q000453:epidemiology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009669:Nose Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D016016:Proportional Hazards Models