The hepatocyte growth factor receptor (MET) gene is not associated with refractive error and ocular biometrics in a Caucasian population.
OBJECTIVE
The purpose of this study was to determine if genetic variants in the hepatocyte growth factor receptor (MET) gene are associated with refractive error and ocular biometric measures in a Caucasian cohort.


METHODS
A case-control association study using 818 Caucasian adults (37.2% male, 62.8% female; average age: 51.21+/-17.17 years) was undertaken. All individuals were genotyped for 16 tag single nucleotide polymorphisms (tSNPs) across the MET gene region. Myopia was defined as -0.5 DS or worse in both eyes and divided into high myopia (<or=-6.0 DS) and low/moderate myopia (-0.5 DS to -5.99 DS). Hypermetropia was defined as at least +1.0 DS in both eyes. Genotyping results were analyzed using PLINK, comparing cases (all myopia, high myopia, low/moderate myopia, and hypermetropia) to controls (emmetropia). Association tests were also performed using the quantitative traits of refraction, axial length, anterior chamber depth, and corneal curvature.


RESULTS
No statistically significant genetic associations were detected for any of the 16 tSNPs with refractive error (myopia and hypermetropia) or ocular biometric measures.


CONCLUSIONS
These data indicate there is likely no genetic association of the MET gene with myopia, axial length, anterior chamber depth, and corneal curvature in this cohort.
Schache
M
M
Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia. mschache@unimelb.edu.au
Chen
C Y
CY
Dirani
M
M
Baird
P N
PN
D001699:Biometry; D003315:Cornea / Q000473:pathology; D003710:Demography; D005091:Exons / Q000235:genetics; D005123:Eye / Q000473:pathology*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D006956:Hyperopia / Q000150:complications / Q000235:genetics; D007438:Introns / Q000235:genetics; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D019859:Proto-Oncogene Proteins c-met / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D012030:Refractive Errors / Q000150:complications / Q000235:genetics*; D044465:White People / Q000235:genetics*
D019859:Proto-Oncogene Proteins c-met