[Oral sedation with midazolam in blepharoplasty].
OBJECTIVE
To evaluate the safety and usefulness of the use of oral sedation with midazolam (15 mg) in patients submitted to blepharoplasty.


METHODS
Randomized double-blind prospective study of 42 patients (surgical risk ASA I and II) divided into three groups of 14 patients each: Group M (midazolam 15 mg), group P (placebo) and group SM (no medication). All patients were evaluated according to the degree of sedation and pain during surgery and the variation of anxiety between the preoperative and intraoperative period, arterial pressure (systolic-SAP and diastolic-DAP), respiratory frequency (RF) and pulsation.


RESULTS
Unifatorial variance analysis with Tukey test demonstrated that the use of midazolam provoked a significant SAP and RF reduction during the intraoperative period. These effects were not pronounced and were accompanied by a reduction of pain perception and anxiety and mild sedation.


CONCLUSIONS
Oral sedation with midazolam in patients that had undergone eyelid surgical procedures is safe and easy to perform with minimal systemic effects.
Gonçalves
Rejane Dantas Rodrigues
RD
Departamento de Oftalmologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
Cruz
Antonio Augusto Velasco E
AA
D000759:Adjuvants, Anesthesia / Q000008:administration & dosage*; D000284:Administration, Oral; D001007:Anxiety / Q000378:metabolism; D019882:Blepharoplasty; D001794:Blood Pressure / Q000187:drug effects; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008874:Midazolam / Q000008:administration & dosage*; D010146:Pain / Q000378:metabolism; D011300:Preoperative Care; D012119:Respiration / Q000187:drug effects
D000759:Adjuvants, Anesthesia; D008874:Midazolam