title: Postexposure prophylaxis of H1N1 with oseltamivir in a newly transplanted kidney recipient receiving intense immunosuppressive therapy.
abstract: Solid organ transplant recipients undergoing immunosuppressive therapy are considered to be at high risk for serious infectious complications. Recently in the United States, a pandemic of H1N1 flu infection has been reported with serious complications. We describe H1N1 infection in a living kidney donor and the 42-year-old kidney transplant recipient exposed to this kidney donor and undergoing intense immunosuppressive therapy. Postexposure prophylaxis with oseltamivir was effective to prevent H1N1 influenza A virus in a donor and a recipient.
authors.affiliation: Department of Pharmacy, Montefiore Medical Center, Bronx, New York, New York 10467, USA.
authors.forename: K
authors.initials: K
authors.lastname: Marfo
authors.forename: J
authors.initials: J
authors.lastname: Chapochnick-Friedmann
authors.forename: E
authors.initials: E
authors.lastname: Akalin
authors.forename: A
authors.initials: A
authors.lastname: Lu
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use*; D002585:Cesarean Section; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects*; D007251:Influenza, Human / Q000517:prevention & control* / Q000635:transmission; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000502:physiology*; D019520:Living Donors; D008487:Medical History Taking; D053139:Oseltamivir / Q000627:therapeutic use*; D011247:Pregnancy; D006435:Renal Dialysis; D012307:Risk Factors; D000069283:Rituximab; D035781:Siblings; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000961:Antilymphocyte Serum; D000998:Antiviral Agents; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D053139:Oseltamivir; D000069283:Rituximab