Integration of gene ontology pathways with North American Rheumatoid Arthritis Consortium genome-wide association data via linear modeling.
We describe an empirical Bayesian linear model for integration of functional gene annotation data with genome-wide association data. Using case-control study data from the North American Rheumatoid Arthritis Consortium and gene annotation data from the Gene Ontology, we illustrate how the method can be used to prioritize candidate genes for further investigation.
Lebrec
Jérémie Jp
JJ
Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, P,O, Box 9604, 2300 RC Leiden, The Netherlands. j.j.p.lebrec@lumc.nl.
Huizinga
Tom Wj
TW
Toes
René Em
RE
Houwing-Duistermaat
Jeanine J
JJ
van Houwelingen
Hans C
HC