title: Transurethral resection of the prostate for the treatment of lower urinary tract symptoms related to benign prostatic hyperplasia: how much should be resected?
abstract: OBJECTIVE
  To assess the impact of the percent of resected tissue on the improvement of urinary symptoms.
  
  
  METHODS
  The study included a prospective analysis of 88 men with benign prostatic hyperplasia. Patients were divided in three groups according to the percent of resected tissue: Group 1 < 30%; Group 2, 30% to 50%; and Group 3, > 50%. Each patient was re-evaluated 3 months after surgery. We assessed the international prostatic symptom score, nocturia and serum prostate specific antigen levels.
  
  
  RESULTS
  All patients presented a significant decrease on mean International Prostate System Score (IPSS) (23 to 5.9), Quality of Life (QoL) (4.9 to 1.0) and nocturia (3.2 to 1.9). Variation in the IPSS was 16.7, 16.6 and 18.4 for patients from Group 1, 2 and 3 respectively (P = 0.504). Although the three groups presented a significant decrease in QoL, patients in Group 3 presented a significantly greater decrease when compared to Group 1. Variation in QoL was 3.1, 3.9 and 4.2 for patients from Group 1, 2 and 3 respectively (p = 0.046). There was no significant difference in nocturia variation according to the percent of resected tissue (p = 0.504). Median pre and postoperative PSA value was 3.7 and 1.9 ng/mL respectively. Patients from Group 1 did not show a significant variation (p = 0.694). Blood transfusions were not required in any group.
  
  
  CONCLUSIONS
  Resection of less than 30% of prostatic tissue seems to be sufficient to alleviate lower urinary tract symptoms related to benign prostate hyperplasia. However, these patients may not show a significant decrease in serum PSA level.
authors.affiliation: Division of Urology, University of Sao Paulo Medical School, Sao Paulo, SP, Brazil. antunesuro@uol.com.br
authors.forename: Alberto A
authors.initials: AA
authors.lastname: Antunes
authors.forename: Miguel
authors.initials: M
authors.lastname: Srougi
authors.forename: Rafael F
authors.initials: RF
authors.lastname: Coelho
authors.forename: Katia R
authors.initials: KR
authors.lastname: Leite
authors.forename: Geraldo de C
authors.initials: Gde C
authors.lastname: Freire
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000097:blood / Q000150:complications / Q000601:surgery*; D020728:Transurethral Resection of Prostate; D016896:Treatment Outcome; D014555:Urination Disorders / Q000209:etiology / Q000601:surgery*
chemical_list: D017430:Prostate-Specific Antigen