Incidence of seizures associated with iopamidol or iomeprol myelography in dogs with intervertebral disk disease: 161 cases (2000-2002).
OBJECTIVE
To compare the incidence of seizures in dogs with intervertebral disk disease after iopamidol or iomeprol myelography, and to assess whether the incidence of seizures differed between the 2 agents when severity of neurological deficits, location of cord compression, duration of anesthesia, site of myelogram, volume of contrast, and concentration of contrast were evaluated.


METHODS
Retrospective study.


METHODS
Veterinary teaching hospital.


METHODS
One hundred and sixty-one client-owned dogs with intervertebral disk disease.


METHODS
Subarachnoid injection of contrast medium.


RESULTS
One hundred and sixty-one dogs with intervertebral disk disease were subjected to myelography using iopamidol (n=74) or iomeprol (n=87). Cranial myelography was performed in 31 dogs, caudal myelography in 125 and both cranial and caudal myelography in 5. Seizures occurred in 23 of 161 (14%) dogs. There was no significant difference overall between iopamidol and iomeprol myelography. However, in dogs with thoracolumbar disk extrusion and paraplegia, seizures occurred more frequently after caudal myelography using iopamidol compared with iomeprol.


CONCLUSIONS
Both iomeprol and iopamidol are suitable for myelography in dogs. Iomeprol is recommended for caudal myelography in paraplegic dogs with thoracolumbar disk extrusion due to the higher incidence of seizures in this group when iopamidol was used.
Lexmaulova
Leona
L
Department of Surgery and Orthopedics, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic. rauseroval@vfu.cz
Zatloukal
Josef
J
Proks
Pavel
P
Dvorak
Milan
M
Srnec
Robert
R
Rauser
Petr
P
Kecova
Helga
H
Necas
Alois
A
D000818:Animals; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging; D003287:Contrast Media / Q000009:adverse effects*; D004283:Dog Diseases / Q000139:chemically induced* / Q000453:epidemiology*; D004285:Dogs; D005260:Female; D007405:Intervertebral Disc Displacement / Q000000981:diagnostic imaging / Q000662:veterinary; D007479:Iopamidol / Q000009:adverse effects* / Q000031:analogs & derivatives*; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D015999:Multivariate Analysis; D009192:Myelography / Q000009:adverse effects / Q000662:veterinary*; D010264:Paraplegia / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D012582:Schools, Veterinary; D012640:Seizures / Q000139:chemically induced / Q000453:epidemiology / Q000662:veterinary*
D003287:Contrast Media; C057937:iomeprol; D007479:Iopamidol