title: [Glyoxal: a possible polyvalent substitute for formaldehyde in pathology?].
abstract: The quest for formaldehyde substitutes is motivated by two fundamental developments: the OSHA regulation standard declaring it hazardous and advocating its substitution with less dangerous chemicals and the fact that formalin is a poor preserver of nucleic acids. Among the non-alcoholic formalin substitute, glyoxal has been hailed as the best alternative. In this work, we showed that glyoxal-containing fixatives are not plausible polyvalent substitution options.
authors.affiliation: Equipe d'accueil signalisation et génomique fonctionnelle en recherche translationnelle oncologique, service d'anatomie et cytologie pathologiques, hôpitaux de Brabois, CHU de Nancy, université de Nancy, 5, allée du Morvan, 54511 Vandoeuvre-lès-Nancy, France. n.marcon@chu-nancy.fr
authors.forename: Nathalie
authors.initials: N
authors.lastname: Marcon
authors.forename: Aude
authors.initials: A
authors.lastname: Bressenot
authors.forename: Karine
authors.initials: K
authors.lastname: Montagne
authors.forename: Claire
authors.initials: C
authors.lastname: Bastien
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Champigneulle
authors.forename: Nathalie
authors.initials: N
authors.lastname: Monhoven
authors.forename: Eliane
authors.initials: E
authors.lastname: Albuisson
authors.forename: François
authors.initials: F
authors.lastname: Plénat
mesh_terms: D004202:Disinfectants; D005404:Fixatives; D005557:Formaldehyde / Q000031:analogs & derivatives*; D006037:Glyoxal / Q000737:chemistry*; D009696:Nucleic Acids / Q000737:chemistry; D011310:Preservatives, Pharmaceutical / Q000592:standards*; D016707:Tissue Fixation / Q000592:standards; D014481:United States; D014489:United States Occupational Safety and Health Administration / Q000331:legislation & jurisprudence
chemical_list: D004202:Disinfectants; D005404:Fixatives; D009696:Nucleic Acids; D011310:Preservatives, Pharmaceutical; D005557:Formaldehyde; D006037:Glyoxal