title: Modulation of antioxidative response in the therapy of hypertension and other cardiovascular diseases.
abstract: OBJECTIVE
  This paper reviews and compares major approaches and strategies to modulation of antioxidative response in the therapy of hypertension and cardiovascular diseases.
  
  
  METHODS
  There are two major strategies of modulation of antioxidative response in hypertension and cardiovascular diseases: (i) modulation of NO levels by NOS stimulation, increase of NO bioavailability, administration of NO, and NOS gene incorporation; (ii) scavenging of superoxide and suppression of oxidative stress by activation of antioxidant gene expression or by suppression of selected genes by RNA silencing. These strategies are accomplished by several concepts, including (1) delivery of external agents, (2) antioxidant gene therapy and RNA silencing, and (3) combined therapies and approaches.
  
  
  CONCLUSIONS
  Combined therapies and approches often achieve multiplicative effects and are the most promising attitude in antioxidant-oriented therapy of hypertension and cardiovascular diseases.
authors.affiliation: Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Slovakia. ima.dovinova@savba.sk
authors.forename: Ima
authors.initials: I
authors.lastname: Dovinova
authors.forename: Roman
authors.initials: R
authors.lastname: Gardlik
authors.forename: Roland
authors.initials: R
authors.lastname: Palffy
authors.forename: Frantisek
authors.initials: F
authors.lastname: Kristek
authors.forename: Sona
authors.initials: S
authors.lastname: Cacanyiova
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Vantova
authors.forename: Helena
authors.initials: H
authors.lastname: Paulikova
mesh_terms: D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000628:therapy*; D006801:Humans; D006973:Hypertension / Q000378:metabolism* / Q000628:therapy*
chemical_list: D000975:Antioxidants