title: Complete genome sequence and taxonomic position of anguillid herpesvirus 1.
abstract: Eel herpesvirus or anguillid herpesvirus 1 (AngHV1) frequently causes disease in freshwater eels. The complete genome sequence of AngHV1 and its taxonomic position within the family Alloherpesviridae were determined. Shotgun sequencing revealed a 249 kbp genome including an 11 kbp terminal direct repeat that contains 7 of the 136 predicted protein-coding open reading frames. Twelve of these genes are conserved among other members of the family Alloherpesviridae and another 28 genes have clear homologues in cyprinid herpesvirus 3. Phylogenetic analyses based on amino acid sequences of five conserved genes, including the ATPase subunit of the terminase, confirm the position of AngHV1 within the family Alloherpesviridae, where it is most closely related to the cyprinid herpesviruses. Our analyses support a recent proposal to subdivide the family Alloherpesviridae into two sister clades, one containing AngHV1 and the cyprinid herpesviruses and the other containing Ictalurid herpesvirus 1 and the ranid herpesviruses.
authors.affiliation: Central Veterinary Institute of Wageningen UR, PO Box 65, 8200 AB Lelystad, The Netherlands.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: van Beurden
authors.forename: Alex
authors.initials: A
authors.lastname: Bossers
authors.forename: Michal H A
authors.initials: MH
authors.lastname: Voorbergen-Laarman
authors.forename: Olga L M
authors.initials: OL
authors.lastname: Haenen
authors.forename: Sander
authors.initials: S
authors.lastname: Peters
authors.forename: Marleen H C
authors.initials: MH
authors.lastname: Abma-Henkens
authors.forename: Ben P H
authors.initials: BP
authors.lastname: Peeters
authors.forename: Peter J M
authors.initials: PJ
authors.lastname: Rottier
authors.forename: Marc Y
authors.initials: MY
authors.lastname: Engelsma
mesh_terms: D000818:Animals; D001483:Base Sequence; D004524:Eels / Q000821:virology*; D016679:Genome, Viral; D006564:Herpesviridae / Q000145:classification* / Q000235:genetics; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010802:Phylogeny