New pH-dependent complexes, from mononuclear Pd(II) monomer to heteronuclear [Pd(II),K(I)]Polymer: DNA cleavage and cytotoxicity in vitro.
Two novel complexes, namely, [Pd(pdc)(2)].(dmp).6H(2)O (1) and [Pd(pdc)(2)K(H(2)O)(5).3H(2)O]n (2) [H(2)pdc=pyridine-2,3-dicarboxylate acid, dmp=2,9-Dimethyl-1,10-phenanthroline] were synthesized and characterized as pH-dependent products. Gel electrophoresis assay demonstrated the ability of the complexes to cleave the pBR 322 plasmid DNA. Values of IC(50) calculated for complexes 1 and 2 show that the two complexes exhibit good cytotoxic activity against different cell lines tested in general, especially more effective against HL-60 and A2780(cisR) cell lines.
Gao
En-Jun
EJ
Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang 110142, PR China. ejgao@yahoo.com.cn
Zhu
Ming-Chang
MC
Huang
Yun
Y
Liu
Lei
L
Liu
Hong-Yan
HY
Liu
Fu-Chun
FC
Ma
Shuang
S
Shi
Chun-Yue
CY
D000970:Antineoplastic Agents / Q000737:chemistry*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D053837:DNA Cleavage; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D006860:Hydrogen Bonding; D006863:Hydrogen-Ion Concentration; D020128:Inhibitory Concentration 50; D046911:Macromolecular Substances; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D000970:Antineoplastic Agents; D046911:Macromolecular Substances; D009944:Organoplatinum Compounds; D010165:Palladium