title: Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies.
abstract: BACKGROUND
  Chikungunya fever is an emerging arboviral disease characterized by an algo-eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to years. Up to now, the pathophysiology of the chronic stage is poorly understood.
  
  
  METHODS
  We report the first case of CHIKV infection with chronic associated rheumatism in a patient who developed progressive erosive arthritis with expression of inflammatory mediators and persistence of specific IgM antibodies over 24 months following infection.
  
  
  CONCLUSIONS
  Understanding the specific features of chikungunya virus as well as how the virus interacts with its host are essential for the prevention, treatment or cure of chikungunya disease.
authors.affiliation: Travel Clinics and Tropical Disease Unit, Department of Internal Medicine, Infectious Diseases and Tropical Medicine, University Hospital Center, Bordeaux, F-33075 France. denis.malvy@chu-bordeaux.fr
authors.forename: Denis
authors.initials: D
authors.lastname: Malvy
authors.forename: Khaled
authors.initials: K
authors.lastname: Ezzedine
authors.forename: Maria
authors.initials: M
authors.lastname: Mamani-Matsuda
authors.forename: Brigitte
authors.initials: B
authors.lastname: Autran
authors.forename: Hugues
authors.initials: H
authors.lastname: Tolou
authors.forename: Marie-Catherine
authors.initials: MC
authors.lastname: Receveur
authors.forename: Thierry
authors.initials: T
authors.lastname: Pistone
authors.forename: Jérome
authors.initials: J
authors.lastname: Rambert
authors.forename: Daniel
authors.initials: D
authors.lastname: Moynet
authors.forename: Djavad
authors.initials: D
authors.lastname: Mossalayi
mesh_terms: D018354:Alphavirus Infections / Q000097:blood / Q000150:complications* / Q000276:immunology; D000914:Antibodies, Viral / Q000097:blood*; D001170:Arthritis, Infectious / Q000097:blood / Q000209:etiology* / Q000276:immunology; D002646:Chikungunya virus / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M