title: [Study on the association of the CRP gene +1444C/T polymorphism with symptomatic carotid artery stenosis].
abstract: OBJECTIVE
  To investigate the potential association of the C-reactive protein (CRP) gene +1444C/T polymorphism with symptomatic carotid artery stenosis.
  
  
  METHODS
  Polymerase chain reaction-restriction fragment length polymorphism was used for the detection of CRP +1444C/T genotypes in 192 patients with symptomatic carotid artery stenosis and 197 healthy controls. Serum high sensitivity-CRP (hs-CRP) levels were measured by routine method.
  
  
  RESULTS
  No TT genotype was detected in this study. Patients with >70% stenosis had higher CC genotype compared with those with <70% stenosis after adjusting for major cerebrovascular risk factors (OR: 2.958; 95% CI: 1.198 - 7.305; P=0.019). CRP levels were significantly higher in patients than in controls. Subgroup analysis according to clinical characteristics (single or double stenosis; >70% or <70% stenosis) did not show difference in CRP levels. There was no significant difference in the prevalence of CT genotype between patients and controls, or between single and double stenosis (P>0.05).
  
  
  CONCLUSIONS
  The CRP +1444 CC genotype is a risk factor for >70% carotid artery stenosis. The serum CRP level is associated with the presence of carotid stenosis. However, it is not associated with the number and severity of stenosis.
authors.affiliation: Center for Laboratory Diagnosis, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050 P.R. China.
authors.forename: Zhi-zhong
authors.initials: ZZ
authors.lastname: Liu
authors.forename: Xiu-rong
authors.initials: XR
authors.lastname: Ding
authors.forename: Hua-guang
authors.initials: HG
authors.lastname: Zheng
authors.forename: Guo
authors.initials: G
authors.lastname: Zhang
authors.forename: Rui-min
authors.initials: RM
authors.lastname: Wang
authors.forename: Xi-xiong
authors.initials: XX
authors.lastname: Kang
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000235:genetics* / Q000378:metabolism; D016893:Carotid Stenosis / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D002097:C-Reactive Protein