Characterization of enteroglial cells and denervation process in chagasic patients with and without megaesophagus.
Chagas disease is caused by infestation with the parasite Trypanosoma cruzi, and some patients who are serologically positive develop chronic megaesophagus, whereas others are symptom-free. Gastrointestinal form of Chagas disease involves an inflammatory invasion of the enteric plexuses and degeneration of enteric neurons and previous works related that enteroglial cells would be involved in enteric inflammatory responses. Because of this, the aims of this study were to determine the relation of enteroglial cells with the denervation process in chagasic patients with and without megaesophagus and seronegative individuals. Our results indicated that the innervation of the esophageal muscle was substantially reduced in patients with megaesophagus, but asymptomatic seropositive subjects were not different to seronegative controls. Besides, patients with megaesophagus had significant decreased of enteroglial cells labeled with S-100 and glial fibrillary acidic protein, whereas patients without megaesophagus presented an increased of both labels. We believe that enteroglial cells would operate a mechanism of defense in the enteric nervous system against the Trypanosoma cruzi infection, which could prevent the organ denervation and preserve the esophagus function.
Nascimento
Rodolfo Duarte
RD
Department of Morphology, ICB, Universidade Federal de Minas Gerais, CEP 31.270-901, Brazil.
de Souza Lisboa
André
A
Fujiwara
Ricardo Toshio
RT
de Freitas
Michelle Aparecida Ribeiro
MA
Adad
Sheila Jorge
SJ
Oliveira
Rodrigo Correa
RC
d'Avila Reis
Débora
D
da Silveira
Alexandre Barcelos Morais
AB
D014355:Chagas Disease / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D017615:Enteric Nervous System / Q000473:pathology*; D004931:Esophageal Achalasia / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D004941:Esophagitis / Q000276:immunology / Q000473:pathology; D004947:Esophagus / Q000276:immunology / Q000294:innervation*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009457:Neuroglia / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism
D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins