title: Novel metabolic pathway for salicylate biodegradation via phenol in yeast Trichosporon moniliiforme.
abstract: A novel metabolic pathway was found in the yeast Trichosporon moniliiforme WU-0401 for salicylate degradation via phenol as the key intermediate. When 20 mM salicylate was used as the sole carbon source for the growth of strain WU-0401, phenol was detected as a distinct metabolite in the culture broth. Analysis of the products derived from salicylate or phenol through reactions with resting cells and a cell-free extract of strain WU-0401 indicated that salicylate is initially decarboxylated to phenol and then oxidized to catechol, followed by aromatic ring cleavage to form cis-cis muconate.
authors.affiliation: Faculty of Science and Engineering, Department of Applied Chemistry, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo, 169-8555, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Gunji
authors.forename: Kuniki
authors.initials: K
authors.lastname: Kino
authors.forename: Takasumi
authors.initials: T
authors.lastname: Hattori
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Ishii
authors.forename: Kohtaro
authors.initials: K
authors.lastname: Kirimura
mesh_terms: D001673:Biodegradation, Environmental; D010084:Oxidation-Reduction; D019800:Phenol / Q000378:metabolism*; D020156:Salicylic Acid / Q000378:metabolism*; D014250:Trichosporon / Q000378:metabolism*
chemical_list: D019800:Phenol; D020156:Salicylic Acid