title: An elevated level of physical activity is associated with normal lipoprotein(a) levels in individuals from Maracaibo, Venezuela.
abstract: Coronary artery disease is the main cause of death worldwide. Lipoprotein(a) [Lp(a)], is an independent risk factor for coronary artery disease in which concentrations are genetically regulated. Contradictory results have been published about physical activity influence on Lp(a) concentration. This research aimed to determine associations between different physical activity levels and Lp(a) concentration. A descriptive and cross-sectional study was made in 1340 randomly selected subjects (males = 598; females = 712) to whom a complete clinical history, the International Physical Activity Questionnaire, and Lp(a) level determination were made. Statistical analysis was carried out to assess qualitative variables relationship by chi2 and differences between means by one-way analysis of variance considering a P value <0.05 as statistically significant. Results are shown as absolute frequencies, percentages, and mean +/- standard deviation according to case. Physical activity levels were ordinal classified as follows: low activity with 24.3% (n = 318), moderate activity with 35.0% (n = 458), and high physical activity with 40.8% (n = 534). Lp(a) concentration in the studied sample was 26.28 +/- 12.64 (IC: 25.59-26.96) mg/dL. Lp(a) concentration according to low, moderate, and high physical activity levels were 29.22 +/- 13.74, 26.27 +/- 12.91, and 24.53 +/- 11.35 mg/dL, respectively, observing statistically significant differences between low and moderate level (P = 0.004) and low and high level (P < 0.001). A strong association (chi2 = 9.771; P = 0.002) was observed among a high physical activity level and a normal concentration of Lp(a) (less than 30 mg/dL). A lifestyle characterized by high physical activity is associated with normal Lp(a) levels.
authors.affiliation: Endocrine and Metabolic Diseases Research Center Dr. Félix Gómez, School of Medicine, University of Zulia, Maracaibo, Venezuela. valmore@gmail.com
authors.forename: Valmore
authors.initials: V
authors.lastname: Bermúdez
authors.forename: Daniel
authors.initials: D
authors.lastname: Aparicio
authors.forename: Edward
authors.initials: E
authors.lastname: Rojas
authors.forename: Lianny
authors.initials: L
authors.lastname: Peñaranda
authors.forename: Freddy
authors.initials: F
authors.lastname: Finol
authors.forename: Luis
authors.initials: L
authors.lastname: Acosta
authors.forename: Edgardo
authors.initials: E
authors.lastname: Mengual
authors.forename: Joselyn
authors.initials: J
authors.lastname: Rojas
authors.forename: Nailet
authors.initials: N
authors.lastname: Arráiz
authors.forename: Alexandra
authors.initials: A
authors.lastname: Toledo
authors.forename: Carlos
authors.initials: C
authors.lastname: Colmenares
authors.forename: Jesica
authors.initials: J
authors.lastname: Urribarí
authors.forename: Wireynis
authors.initials: W
authors.lastname: Sanchez
authors.forename: Carlos
authors.initials: C
authors.lastname: Pineda
authors.forename: Dalia
authors.initials: D
authors.lastname: Rodriguez
authors.forename: Judith
authors.initials: J
authors.lastname: Faria
authors.forename: Roberto
authors.initials: R
authors.lastname: Añez
authors.forename: Raquel
authors.initials: R
authors.lastname: Cano
authors.forename: Clímaco
authors.initials: C
authors.lastname: Cano
authors.forename: Luis
authors.initials: L
authors.lastname: Sorell
authors.forename: Manuel
authors.initials: M
authors.lastname: Velasco
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000818:Animals; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008019:Life Style; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014687:Venezuela; D055815:Young Adult
chemical_list: D017270:Lipoprotein(a)