title: Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.
abstract: A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron isotropic resolution. The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies.
authors.affiliation: Duke University, Durham, NC, USA. samei@duke.edu
authors.forename: Ehsan
authors.initials: E
authors.lastname: Samei
authors.forename: Robert S
authors.initials: RS
authors.lastname: Saunders
authors.forename: Cristian T
authors.initials: CT
authors.lastname: Badea
authors.forename: Ketan B
authors.initials: KB
authors.lastname: Ghaghada
authors.forename: Laurence W
authors.initials: LW
authors.lastname: Hedlund
authors.forename: Yi
authors.initials: Y
authors.lastname: Qi
authors.forename: Hong
authors.initials: H
authors.lastname: Yuan
authors.forename: Rex C
authors.initials: RC
authors.lastname: Bentley
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Mukundan
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media; D005260:Female; D007479:Iopamidol / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D015674:Mammary Neoplasms, Animal / Q000000981:diagnostic imaging*; D008327:Mammography / Q000379:methods*; D053758:Nanoparticles; D011856:Radiographic Image Enhancement / Q000379:methods*; D051381:Rats; D011916:Rats, Inbred F344; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D008081:Liposomes; D007479:Iopamidol