title: Pseudometastasis secondary to histoplasmosis infection: false-positive PET/CT findings.
abstract: Positron emission computed tomography (PET)/CT is a common modality used in the workup of neoplastic conditions. However, false-positive results may be produced by underlying infectious processes. We report two cases of false-positive PET/CT studies secondary to histoplasmosis infections in both a pediatric and a young adult patient. After the diagnoses, one patient was observed with no therapy and the other received a complete course of itraconazole. In both cases biopsy results were positive for fungal elements consistent with histoplasmosis. Both patients were successfully managed and have had follow-up histoplasmosis titers that reveal resolving infections.
authors.affiliation: Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Ross
authors.initials: R
authors.lastname: Perko
authors.forename: Yoav
authors.initials: Y
authors.lastname: Messinger
authors.forename: Christopher
authors.initials: C
authors.lastname: Moertel
mesh_terms: D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000473:pathology; D003937:Diagnosis, Differential; D005189:False Positive Reactions; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology; D006660:Histoplasmosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008168:Lung / Q000382:microbiology / Q000473:pathology*; D008297:Male; D009362:Neoplasm Metastasis / Q000473:pathology*; D049268:Positron-Emission Tomography; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole