title: Radiofrequency coblation for treatment of advanced laryngotracheal recurrent respiratory papillomatosis.
abstract: BACKGROUND
  A variety of treatment modalities are currently used to treat recurrent respiratory papillomatosis. We aimed to study the efficacy of radiofrequency cold ablation (coblation) for the treatment of laryngotracheal recurrent respiratory papillomatosis, by comparing treatment intervals for coblation and CO2 laser vaporisation.
  
  
  METHODS
  Retrospective case series of adult patients with advanced laryngotracheal recurrent respiratory papillomatosis.
  
  
  RESULTS
  Six patients were treated for at least two years by CO2 laser vaporisation with or without intralesional cidofovir. All six subsequently underwent treatment with radiofrequency coblation with or without intralesional cidofovir. Coblation resulted in longer periods between interventions, compared with CO2 laser (p = 0.03).
  
  
  CONCLUSIONS
  Radiofrequency coblation appears to be an attractive alternative technique to CO2 laser for the surgical treatment of advanced laryngotracheal papillomata.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Flinders Medical Centre and Flinders University, Adelaide, South Australia, Australia.
authors.forename: A S
authors.initials: AS
authors.lastname: Carney
authors.forename: A S
authors.initials: AS
authors.lastname: Evans
authors.forename: S
authors.initials: S
authors.lastname: Mirza
authors.forename: A
authors.initials: A
authors.lastname: Psaltis
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017115:Catheter Ablation / Q000295:instrumentation / Q000379:methods*; D000077404:Cidofovir; D003131:Combined Modality Therapy; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D004724:Endoscopy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000601:surgery*; D054020:Lasers, Gas / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000627:therapeutic use; D010212:Papilloma / Q000188:drug therapy / Q000601:surgery*; D012008:Recurrence; D012189:Retrospective Studies; D014134:Tracheal Neoplasms / Q000188:drug therapy / Q000601:surgery*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir