Promoting developmental transcription.
Animal growth and development depend on the precise control of gene expression at the level of transcription. A central role in the regulation of developmental transcription is attributed to transcription factors that bind DNA enhancer elements, which are often located far from gene transcription start sites. Here, we review recent studies that have uncovered significant regulatory functions in developmental transcription for the TFIID basal transcription factors and for the DNA core promoter elements that are located close to transcription start sites.
Ohler
Uwe
U
Institute for Genome Sciences & Policy, Departments of Biostatistics & Bioinformatics and Computer Science, Duke University, Durham, NC 27708, USA.
Wassarman
David A
DA
D000818:Animals; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008954:Models, Biological; D011401:Promoter Regions, Genetic / Q000235:genetics; D035362:Transcription Factor TFIID / Q000235:genetics*; D024363:Transcription Initiation Site; D014158:Transcription, Genetic / Q000235:genetics*
D035362:Transcription Factor TFIID