title: Meningeal carcinomatosis from penile squamous cell carcinoma.
abstract: We report herein a clinical case of a patient with meningeal carcinomatosis from penile squamous cell carcinoma. A 68-year-old man presented with mental changes, headaches, and unstable gait. Examinations revealed brain metastases and infiltration of the leptomeninges and subarachnoid space by carcinoma cells. Only 11 months earlier the patient had been diagnosed with penile squamous cell carcinoma of poor differentiation and had underwent subtotal penectomy and adjuvant chemotherapy and radiation. Infiltration of the central nervous system with penile cancer is extremely rare, and only five cases with brain metastases have been described to date. This is the first report of a patient with penile cancer spread to the leptomeninges.
authors.affiliation: Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. skripuletz.thomas@mh-hannover.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Skripuletz
authors.forename: Refik
authors.initials: R
authors.lastname: Pul
authors.forename: Julian
authors.initials: J
authors.lastname: Herrmann
authors.forename: Eva
authors.initials: E
authors.lastname: Bueltmann
authors.forename: Ulrich
authors.initials: U
authors.lastname: Wurster
authors.forename: Martin
authors.initials: M
authors.lastname: Stangel
authors.forename: Corinna
authors.initials: C
authors.lastname: Trebst
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000473:pathology / Q000556:secondary*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D006801:Humans; D008297:Male; D055756:Meningeal Carcinomatosis / Q000473:pathology / Q000556:secondary*; D010412:Penile Neoplasms / Q000473:pathology*; D015898:Tomography Scanners, X-Ray Computed