Wireless capsule endoscopy in enteropathy induced by nonsteroidal anti-inflammatory drugs in pigs.
OBJECTIVE
The aim of this study is to evaluate the diagnostic yield of capsule endoscopy in nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy in pigs.


METHODS
Indomethacin (400 mg/day) was administrated orally for 10 days to eight female pigs weighing 36.3+/-2.4 kg. Afterwards, capsule endoscopy was performed, using the EndoCapsule system (Olympus Optical Co., Tokyo, Japan). The following morning, pharmacological euthanasia and immediate autopsy were performed.


RESULTS
Small bowel injury compatible with NSAID-induced enteropathy was observed in 7/8 animals. The most common lesions were red spots and erosions. Ulcers and small intestinal bleeding were identified sporadically. Sensitivity and specificity of capsule endoscopy were 83.3% and 95.8%, respectively.


CONCLUSIONS
Our results indicate that wireless capsule endoscopy is a highly accurate noninvasive method for evaluation of experimental NSAID-induced enteropathy.
Tachecí
Ilja
I
Second Department of Internal Medicine, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Teaching Hospital, Hradec Králové, Czech Republic. tacheci@gmail.com
Kvetina
Jaroslav
J
Bures
Jan
J
Osterreicher
Jan
J
Kunes
Martin
M
Pejchal
Jaroslav
J
Rejchrt
Stanislav
S
Spelda
Stanislav
S
Kopácová
Marcela
M
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D053704:Capsule Endoscopy; D004195:Disease Models, Animal; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000175:diagnosis; D004386:Duodenum / Q000473:pathology; D005260:Female; D007082:Ileum / Q000473:pathology; D007213:Indomethacin; D007410:Intestinal Diseases / Q000139:chemically induced / Q000175:diagnosis*; D007413:Intestinal Mucosa / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology*; D007583:Jejunum / Q000473:pathology; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced / Q000175:diagnosis; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D034421:Sus scrofa
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin