title: Successful mobilization, harvest and transplant of peripheral blood stem cells using AMD3100 and G-CSF following high dose craniospinal irradiation for medulloblastoma in a young child.
abstract: Contemporary protocols for the treatment of malignant brain tumors such as medulloblastoma (MB) in children, often involve craniospinal irradiation (CSI) at diagnosis followed by serial courses of high dose chemotherapy and autologous hematopoietic stem cell support. Patients often require several pheresis procedures in order to collect sufficient stem cells for this type of treatment, particularly if they have already had CSI. We describe the successful mobilization, collection and subsequent transplant of a 7-year-old female with medulloblastoma after recent CSI using granulocyte colony stimulating factor (G-CSF) and the CXCR4 antagonist AMD3100 after a failed previous mobilization attempt using G-CSF alone.
authors.affiliation: Department of Pediatric Hematology Oncology, Petach Tikva, Israel. helent@clalit.org.il
authors.forename: Helen
authors.initials: H
authors.lastname: Toledano
authors.forename: Anat
authors.initials: A
authors.lastname: Yahel
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Cohen
authors.forename: Isaac
authors.initials: I
authors.lastname: Yaniv
authors.forename: Jerry
authors.initials: J
authors.lastname: Stein
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001596:Benzylamines; D002528:Cerebellar Neoplasms / Q000628:therapy*; D002648:Child; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D000080027:Cyclams; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006571:Heterocyclic Compounds / Q000627:therapeutic use*; D006801:Humans; D008527:Medulloblastoma / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors / Q000187:drug effects
chemical_list: D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D001596:Benzylamines; C527276:CXCR4 protein, human; D000080027:Cyclams; D006571:Heterocyclic Compounds; D019718:Receptors, CXCR4; D016179:Granulocyte Colony-Stimulating Factor; D002945:Cisplatin; C088327:plerixafor