Palladium-catalyzed alkoxylation of N-methoxybenzamides via direct sp2 C-H bond activation.
The palladium-catalyzed ortho-alkoxylation of N-methoxybenzamides has been demonstrated. With the CONHOMe group as a directing group, the aromatic C-H bond can be functionalized efficiently to generate ortho-alkoxylated derivatives in moderate to good yields.
Wang
Guan-Wu
GW
CAS Key Laboratory of Soft Matter Chemistry, and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China. gwang@ustc.edu.cn
Yuan
Ting-Ting
TT