The effect of maternal body mass index on neonatal outcome in women receiving a single course of antenatal corticosteroids.
OBJECTIVE
The aim of this study was to determine the effect of maternal body mass index on the incidence of neonatal prematurity morbidities in those who receive corticosteroids.


METHODS
This was a secondary analysis of a trial of corticosteroids in women at risk for preterm birth. Women receiving a single course of corticosteroids were classified by their prepregnancy body mass index (<25 and > or = 25) and compared on a composite outcome comprised of several neonatal morbidities and on each individual outcome.


RESULTS
Of 183 eligible women, 96 (52.5%) had a body mass index of <25 and 87 (47.5%) had a body mass index of > or = 25. The composite outcome occurred more frequently in the body mass index of > or = 2 5 group (28.7%), compared with those with a body mass index of <25 (18.8%), although this was not statistically significant (odds ratio, 1.75; 95% confidence interval, 0.83-3.72). Body mass index was not associated with outcomes after adjusting for confounding.


CONCLUSIONS
Maternal body mass index did not affect neonatal prematurity morbidities in those receiving corticosteroids.
Hashima
Jason N
JN
Department of Obstetrics, Oregon Health & Science University, Portland, OR, USA. hashimaj@ohsu.edu
Lai
Yinglei
Y
Wapner
Ronald J
RJ
Sorokin
Yoram
Y
Dudley
Donald J
DJ
Peaceman
Alan
A
Spong
Catherine Y
CY
Iams
Jay D
JD
Leveno
Kenneth J
KJ
Harper
Margaret
M
Caritis
Steve N
SN
Varner
Michael
M
Miodovnik
Menachem
M
Mercer
Brian M
BM
Thorp
John M
JM
O'Sullivan
Mary J
MJ
Ramin
Susan M
SM
Carpenter
Marshall
M
Rouse
Dwight J
DJ
Sibai
Baha
B
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D001623:Betamethasone / Q000627:therapeutic use; D015992:Body Mass Index; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology / Q000517:prevention & control; D003907:Dexamethasone / Q000627:therapeutic use; D020345:Enterocolitis, Necrotizing / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology* / Q000517:prevention & control*; D007273:Injections, Intramuscular; D020300:Intracranial Hemorrhages / Q000453:epidemiology / Q000517:prevention & control; D007969:Leukomalacia, Periventricular / Q000453:epidemiology / Q000517:prevention & control; D009765:Obesity / Q000453:epidemiology; D011247:Pregnancy; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology / Q000517:prevention & control; D012178:Retinopathy of Prematurity / Q000453:epidemiology / Q000517:prevention & control
D000305:Adrenal Cortex Hormones; D003907:Dexamethasone; D001623:Betamethasone