Transcriptional and post-translational regulation of adiponectin.
Adiponectin is an adipose-tissue-derived hormone with anti-diabetic, anti-atherogenic and anti-inflammatory functions. Adiponectin circulates in the bloodstream in trimeric, hexameric and high-molecular-mass species, and different forms of adiponectin have been found to play distinct roles in the regulation of energy homoeostasis. The serum levels of adiponectin are negatively correlated with obesity and insulin resistance, yet the underlying mechanisms remain elusive. In the present review, we summarize recent progress made on the mechanisms regulating adiponectin gene transcription, multimerization and secretion. We also discuss the potential relevance of these studies to the development of new clinical therapy for insulin resistance, Type 2 diabetes and other obesity-related metabolic disorders.
Liu
Meilian
M
Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Liu
Feng
F
D052242:Adiponectin / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D000818:Animals; D006801:Humans; D008954:Models, Biological; D011401:Promoter Regions, Genetic / Q000235:genetics; D055503:Protein Multimerization; D011499:Protein Processing, Post-Translational; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
D052242:Adiponectin; D014157:Transcription Factors