Red ginseng extract protects against aflatoxin B1 and fumonisins-induced hepatic pre-cancerous lesions in rats.
The current study was conducted to evaluate the chemoprevention effects of ginseng extract (GE) against pre-cancerous lesions in female Sprague-Dawley rats treated with aflatoxin B1 (AFB1) and fumonisin (FB). Six experimental groups treated for 12 weeks and included: the control group; the GE alone-treated group (150 mg/kg b.w); the group treated orally with AFB1 (17 microg/kg b.w) during the first 2 weeks and fed FB-contaminated diet (250 mg/kg diet) during the 6th to 8th weeks; the group treated with GE during the mycotoxin protocol and continued till week 10; the group treated with GE 2 weeks before AFB1 administration and continued till the end of FB treatment and the group treated with GE for 4 weeks after the toxin protocol stopped. The sequential mycotoxins treatment induced significant changes in serum biochemical parameters accompanied by severe histological and histochemical changes of the liver tissue. Treatment with GE during, before or after the treatment with the mycotoxins improved all biochemical parameters and histological picture of the liver. Moreover, treatment with GE after the administration of the mycotoxins was found to be more effective. It could be concluded that GE has a protective effects as pre-cancerous lesions and therapeutic effects as well.
Abdel-Wahhab
Mosaad A
MA
Food Toxicology and Contaminants Dept., National Research Center, Dokki, Cairo, Egypt. mosaad_abdelwahhab@yahoo.com
Hassan
Nabila S
NS
El-Kady
Ahmed A
AA
Khadrawy
Yasser A
YA
El-Nekeety
Aziza A
AA
Mohamed
Sherif R
SR
Sharaf
Hafiza A
HA
Mannaa
Fathia A
FA
D016604:Aflatoxin B1 / Q000633:toxicity; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D018890:Chemoprevention; D005260:Female; D037341:Fumonisins / Q000633:toxicity; D036145:Ginsenosides / Q000032:analysis; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008113:Liver Neoplasms / Q000097:blood / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011230:Precancerous Conditions / Q000097:blood / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley
D016588:Anticarcinogenic Agents; D037341:Fumonisins; D036145:Ginsenosides; D010936:Plant Extracts; D016604:Aflatoxin B1