title: Unilateral radiotherapy for tonsil cancer: potential dose distribution optimization with a simple two-field intensity-modulated radiation therapy beam arrangement.
abstract: OBJECTIVE
  To evaluate the feasibility and dosimetric optimization potential of a unilateral two-field intensity-modulated radiotherapy (IMRT) technique in the curative treatment of lateralized tonsil cancer.
  
  
  METHODS
  Six patients with lateralized tonsillar carcinoma were treated unilaterally with a two-field IMRT technique (oblique-anterior and oblique-posterior fields, with or without collimator and couch rotation). Alternative IMRT plans using seven non-opposed coplanar fields were compared with the two-field plans for each patient.
  
  
  RESULTS
  Planning target volume (PTV) coverage was excellent with the two-field technique, using a relatively low number of monitor units (MU) (median, 441; range, 309-550). Dose constraints were respected for all organs at risk (OAR). Mean doses to contralateral parotid and submandibular glands were 3.9 and 17.7 Gy, respectively. Seven-field IMRT provided similar PTV coverage, with statistically significant better dose homogeneity and conformality. However, the mean delivered dose to the contralateral parotid (3.9 vs. 9.0 Gy, p=0.001) as well as the mean number of MU (437 vs. 814, p=0.002) and consequently machine time were lower with two-field IMRT.
  
  
  CONCLUSIONS
  Unilateral two-field IMRT is a simple and feasible technique providing excellent tumor coverage and optimal OAR sparing while reducing the number of MU and treatment time.
authors.affiliation: Department of Radiation Oncology, Geneva University Hospital, Geneva, Switzerland. Thomas.Zilli@hcuge.ch
authors.forename: Thomas
authors.initials: T
authors.lastname: Zilli
authors.forename: Philippe
authors.initials: P
authors.lastname: Nouet
authors.forename: Nathalie
authors.initials: N
authors.lastname: Casanova
authors.forename: Michael
authors.initials: M
authors.lastname: Betz
authors.forename: Giovanna
authors.initials: G
authors.lastname: Dipasquale
authors.forename: Michel
authors.initials: M
authors.lastname: Rouzaud
authors.forename: Raymond
authors.initials: R
authors.lastname: Miralbell
authors.forename: Mahmut
authors.initials: M
authors.lastname: Ozsahin
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated; D014067:Tonsillar Neoplasms / Q000473:pathology / Q000532:radiotherapy*