title: Differences in the distribution of subtypes according to the WHO classification 2008 between Japanese and German patients with refractory anemia according to the FAB classification in myelodysplastic syndromes.
abstract: We reported the different clinical features between Japanese and German refractory anemia (RA) patients in FAB classification. We re-analyzed the clinical features by WHO classification revised in 2008. The frequencies of refractory cytopenia with unilineage dysplasia (RCUD) and myelodysplastic syndrome-unclassified (MDS-U) with pancytopenia in Japanese patients were higher than in German patients (p<0.001). Refractory cytopenia with multilineage dysplasia patients showed the most unfavorable prognosis in both countries. The higher frequencies of MDS-U with pancytopenia and RCUD in Japanese patients may influence the different clinical characteristics between Japanese and German FAB-RA patients.
authors.affiliation: Department of Hematology, Saitama International Medical Center, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, Japan. amatsu@saitama-med.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuda
authors.forename: Ulrich
authors.initials: U
authors.lastname: Germing
authors.forename: Itsuro
authors.initials: I
authors.lastname: Jinnai
authors.forename: Kayano
authors.initials: K
authors.lastname: Araseki
authors.forename: Andrea
authors.initials: A
authors.lastname: Kuendgen
authors.forename: Corinna
authors.initials: C
authors.lastname: Strupp
authors.forename: Masako
authors.initials: M
authors.lastname: Iwanaga
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hata
authors.forename: Masami
authors.initials: M
authors.lastname: Bessho
authors.forename: Norbert
authors.initials: N
authors.lastname: Gattermann
authors.forename: Masao
authors.initials: M
authors.lastname: Tomonaga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000753:Anemia, Refractory / Q000145:classification* / Q000208:ethnology* / Q000473:pathology; D044466:Asian People; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000145:classification* / Q000208:ethnology* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D014944:World Health Organization; D055815:Young Adult