WD40 repeats arrange histone tails for spreading of silencing.
Direct binding of WD40 repeat of Embryonic Ectoderm Development (EED) in the Polycomb Repressor Complex 2 (PRC2) to the histone H3 tail regulates the H3K27 methyltrasnferase activity of PRC2. The binding activity is required for the methylation of H3K27 over long distance of a Drosophila chromosome from the UBX (Hox gene) promoter to the PBX upstream enhancer region, implying EED initiates propagation of this repressive mark.
Suganuma
Tamaki
T
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Workman
Jerry L
JL
D000818:Animals; D020868:Gene Silencing; D006657:Histones / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D051379:Mice; D008954:Models, Biological; D063146:Polycomb-Group Proteins; D011485:Protein Binding; D020449:Repetitive Sequences, Amino Acid; D012097:Repressor Proteins / Q000378:metabolism
D006657:Histones; D063146:Polycomb-Group Proteins; D012097:Repressor Proteins