title: CMV infection presenting as a cavitary lung lesion in a patient with systemic lupus erythematosus receiving immunosuppressive therapy.
abstract: We report a case of cytomegalovirus (CMV) pneumonitis that presented as a cavitary lung lesion in a patient with systemic lupus erythematosus receiving immunosuppressive treatment. The lesion was confirmed by positive polymerase chain reaction (PCR) for CMV in bronchoalveolar lavage fluid (BALF) and CMV antigenemia. PCR for CMV in BALF was demonstrated to be useful for the diagnosis of CMV pneumonitis on the basis of high sensitivity and specificity. After initiating ganciclovir, the lesion gradually regressed. A cavitary lung lesion associated with CMV is extremely rare. This presentation suggests that the differential diagnosis of cavitary lung lesion in immunocompromised individuals should include CMV.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya. naoazuuh@hyo-med.ac.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Azuma
authors.forename: Naoaki
authors.initials: N
authors.lastname: Hashimoto
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yasumitsu
authors.forename: Kazuya
authors.initials: K
authors.lastname: Fukuoka
authors.forename: Kazunori
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Hisashi
authors.initials: H
authors.lastname: Sawada
authors.forename: Aki
authors.initials: A
authors.lastname: Nishioka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sekiguchi
authors.forename: Masayasu
authors.initials: M
authors.lastname: Kitano
authors.forename: Takanori
authors.initials: T
authors.lastname: Kuroiwa
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Matsui
authors.forename: Hajime
authors.initials: H
authors.lastname: Sano
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000821:virology; D003586:Cytomegalovirus Infections / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents