[Anticonvulsants as bioantioxidants under stress conditions].
The action of heterocyclic amides series (ethosuximide, phenytoin, primidone) on lipid peroxidation and membrane bound monoamine oxidases A and B under stress condition has been studied. The intraperitoneal injection of the drugs resulted in enhancement of SOD, decrease of brain malondialdehyde content and mitochondrial activity of monoamine oxidases A and B.
Bogdanov
G N
GN
Mishchenko
D V
DV
Kotel'nikova
R A
RA
Frog
E S
ES
Faĭngol'd
I I
II
Tat'ianenko
L V
LV
Dorokhotova
O V
OV
Nartsissov
Ia R
IaR
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D005013:Ethosuximide / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008563:Membrane Lipids / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism; D010672:Phenytoin / Q000494:pharmacology; D011324:Primidone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
D000927:Anticonvulsants; D000975:Antioxidants; D008563:Membrane Lipids; D011324:Primidone; D005013:Ethosuximide; D010672:Phenytoin; D013482:Superoxide Dismutase; D008995:Monoamine Oxidase