Kinetics of the lamellar gel-fluid transition in phosphatidylcholine membranes in the presence of sugars.
Phase diagrams are presented for dipalmitoylphosphatidylcholine (DPPC) in the presence of sugars (sucrose) over a wide range of relative humidities (RHs). The phase information presented here, determined by small angle X-ray scattering (SAXS), is shown to be consistent with previous results achieved by differential scanning calorimetry (DSC). Both techniques show a significant effect of sucrose concentration on the phase behaviour of this phospholipid bilayer. An experimental investigation into the effect of sugars on the kinetic behaviour of the gel to fluid transition is also presented showing that increasing the sugar content appears to slightly increase the rate at which the transition occurs.
Lenné
Thomas
T
Applied Physics, RMIT University, Melbourne, Vic 3001, Australia. Thomas.lenne@anu.edu.au
Garvey
Christopher J
CJ
Koster
Karen L
KL
Bryant
Gary
G
D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D005782:Gels / Q000737:chemistry*; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry*; D008560:Membrane Fluidity / Q000187:drug effects; D044367:Phase Transition; D013395:Sucrose / Q000737:chemistry* / Q000494:pharmacology
D005782:Gels; D008051:Lipid Bilayers; D015060:1,2-Dipalmitoylphosphatidylcholine; D013395:Sucrose