Cytotoxic triterpene dilactones from the stems of Kadsura ananosma.
Six new triterpene dilactones with a rare rearranged pentacyclic skeleton, longipedlactones K-P (1-6), and seven known analogues (7-13) were isolated from the stems of Kadsura ananosma. Compound 1 was found to possess a unique peroxide bridge between C-1 and C-9 in rings A and B. The structures of these new compounds were established on the basis of spectroscopic data analysis, especially of their 2D NMR spectra. In the evaluation of the in vitro cytotoxicity of these compounds against a small panel of human cancer cell lines, compounds 3, 7, 9, and 13 were found to be the most potent against HL-60 acute leukemia cell.
Yang
Jian-Hong
JH
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Pu
Jian-Xin
JX
Wen
Jin
J
Li
Xiao-Nian
XN
He
Fei
F
Xue
Yong-Bo
YB
Wang
Yuan-Yuan
YY
Li
Yan
Y
Xiao
Wei-Lie
WL
Sun
Han-Dong
HD
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D032135:Kadsura / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D007783:Lactones; D014315:Triterpenes