title: Are elite endurance athletes genetically predisposed to lower disease risk?
abstract: We compared a polygenic profile that combined 33 disease risk-related mutations and polymorphisms among nonathletic healthy control subjects and elite endurance athletes. The study sample comprised 100 healthy Spanish male nonathletic (sedentary) control subjects and 100 male elite endurance athletes. We analyzed 33 disease risk-related mutations and polymorphisms. We computed a health-related total genotype score (TGS, 0-100) from the accumulated combination of the 33 variants. We did not observe significant differences in genotype or allele distributions among groups, except for the rs4994 polymorphism (P < 0.001). The computed health-related TGS was similar among groups (23.8 +/- 1.0 vs. 24.2 +/- 0.8 in control subjects and athletes, respectively; P = 0.553). Similar results were obtained when computing specific TGSs for each main disease category (cardiovascular disease and cancer). We observed no evidence that male elite endurance athletes are genetically predisposed to have lower disease risk than matched nonathletic control subjects.
authors.affiliation: Universidad Europea de Madrid, Madrid, Spain.
authors.forename: Félix
authors.initials: F
authors.lastname: Gómez-Gallego
authors.forename: Jonatan R
authors.initials: JR
authors.lastname: Ruiz
authors.forename: Amaya
authors.initials: A
authors.lastname: Buxens
authors.forename: Signe
authors.initials: S
authors.lastname: Altmäe
authors.forename: Marta
authors.initials: M
authors.lastname: Artieda
authors.forename: Catalina
authors.initials: C
authors.lastname: Santiago
authors.forename: Marta
authors.initials: M
authors.lastname: González-Freire
authors.forename: Zoraida
authors.initials: Z
authors.lastname: Verde
authors.forename: David
authors.initials: D
authors.lastname: Arteta
authors.forename: Antonio
authors.initials: A
authors.lastname: Martínez
authors.forename: Diego
authors.initials: D
authors.lastname: Tejedor
authors.forename: José I
authors.initials: JI
authors.lastname: Lao
authors.forename: Joaquin
authors.initials: J
authors.lastname: Arenas
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucia
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006262:Health; D006801:Humans; D008297:Male; D010807:Physical Endurance / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D013030:Spain; D044465:White People / Q000235:genetics; D055815:Young Adult