title: Bis-4-aminobenzamidines: versatile, fluorogenic A/T-selective dsDNA binders.
abstract: N(1),N(3)-Bis(4-amidinophenyl)propane-1,3-diamine (BAPPA, R = H) is a bisaminobenzamidine fluorogenic derivative that displays a large increase in its emission fluorescence when bound to the minor groove of specific A/T DNA sites (K(d) for an AATT site approximately 79 +/- 6 nM). Moreover, the structural characteristics of BAPPA allow the easy introduction of functional groups that protrude out of the DNA surface.
authors.affiliation: Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
authors.forename: Olalla
authors.initials: O
authors.lastname: Vázquez
authors.forename: Mateo I
authors.initials: MI
authors.lastname: Sánchez
authors.forename: José
authors.initials: J
authors.lastname: Martínez-Costas
authors.forename: M Eugenio
authors.initials: ME
authors.lastname: Vázquez
authors.forename: José L
authors.initials: JL
authors.lastname: Mascareñas
mesh_terms: D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D003959:Diamines / Q000138:chemical synthesis / Q000737:chemistry*; D005453:Fluorescence; D015394:Molecular Structure; D011407:Propane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D003959:Diamines; C547492:N1,N3-bis(4-amidinophenyl)propane-1,3-diamine; D004247:DNA; D011407:Propane