title: Adhesions and incisional hernias following laparoscopic versus open surgery for colorectal cancer in the CLASICC trial.
abstract: BACKGROUND
  This study investigated adhesive intestinal obstruction (AIO) and incisional hernia (IH) in patients undergoing laparoscopically assisted and open surgery for colorectal cancer.
  
  
  METHODS
  In a case-note review of patients randomized to the Medical Research Council's Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer (CLASICC) trial, primary and key secondary endpoints were AIO and IH admission rates respectively.
  
  
  RESULTS
  Of 411 patients, 11 were admitted for AIO: four (3.1 per cent) of 131 patients in the open arm of the trial versus seven (2.5 per cent) of 280 in the laparoscopic arm (difference 0.6 (95 per cent confidence interval (c.i.) - 2.9 to 4.0) per cent). Thirty-six patients developed IH: 12 (9.2 per cent) after open versus 24 (8.6 per cent) after laparoscopic surgery (difference 0.6 (95 per cent c.i. - 5.3 to 6.5) per cent). Results by actual procedure showed higher AIO and IH rates in the 24.5 per cent of patients who converted from laparoscopic to open surgery (AIO: 2.3, 2.0 and 6 per cent; IH: 8.6, 7.4 and 11 per cent-for open, laparoscopic and converted operations respectively).
  
  
  CONCLUSIONS
  Although this study has not confirmed that laparoscopic surgery reduces rates of AIO and IH after colorectal cancer surgery, trends suggest that a reduction in conversion to open surgery and elimination of port-site hernias may produce such an effect. Registration number for CLASICC trial: ISRCTN74883561 (http://www.controlled-trials.com).
authors.affiliation: Academic Unit of Medicine, Surgery and Anaesthesia, St James's University Hospital, Leeds, UK.
authors.forename: G W
authors.initials: GW
authors.lastname: Taylor
authors.forename: D G
authors.initials: DG
authors.lastname: Jayne
authors.forename: S R
authors.initials: SR
authors.lastname: Brown
authors.forename: H
authors.initials: H
authors.lastname: Thorpe
authors.forename: J M
authors.initials: JM
authors.lastname: Brown
authors.forename: S C
authors.initials: SC
authors.lastname: Dewberry
authors.forename: M C
authors.initials: MC
authors.lastname: Parker
authors.forename: P J
authors.initials: PJ
authors.lastname: Guillou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000601:surgery*; D005260:Female; D006555:Hernia, Ventral / Q000209:etiology*; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology*; D010535:Laparoscopy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000601:surgery*; D012189:Retrospective Studies; D000267:Tissue Adhesions / Q000209:etiology