title: Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components.
abstract: OBJECTIVE
  To investigate the effect of severe acute pancreatitis (SAP) on pharmacokinetics of Da-Cheng-Qi Decoction (DCQD) components in rats.
  
  
  METHODS
  Rats were divided into SAP group and sham-operation group as a control group (n = 6). Rhein, chrysophanol, rheochrysidin, magnolol, hesperidin and naringin in DCQD were quantified in rat serum by high performance liquid chromatography tandem mass spectrometry for studying their pharmacokinetics.
  
  
  RESULTS
  Early absorption of each DCQD component was tended to degrade in SAP group after treatment with DCQD by gavage. The C(max) (chrysophanol, P = 0.0059; rheochrysidin, P = 0.0288; magnolol, P = 0.0487; hesperidin, P = 0.0277; naringin, P = 0.0023) and AUC (rhein, P = 0.0186; chrysophanol, P = 0.0013; magnolol, P = 0.001; hesperidin, P = 0.0081; naringin, P = 0.0272) of DCQD component were obviously lower in SAP group than in control group. The T(1/2alpha) of chrysophanol and rheochrysidin (P = 0.0467 and 0.0005, respectively) and T(max) of chrysophanol and rheochrysidin (P = 0.0101 and 0.0037, respectively) lasted longer in SAP group than in control group.
  
  
  CONCLUSIONS
  SAP can significantly impact the absorption of DCQD components in rats and their pharmacokinetic parameters.
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
authors.forename: Han-Lin
authors.initials: HL
authors.lastname: Gong
authors.forename: Wen-Fu
authors.initials: WF
authors.lastname: Tang
authors.forename: Qin
authors.initials: Q
authors.lastname: Yu
authors.forename: Jin
authors.initials: J
authors.lastname: Xiang
authors.forename: Qing
authors.initials: Q
authors.lastname: Xia
authors.forename: Guang-Yuan
authors.initials: GY
authors.lastname: Chen
authors.forename: Xi
authors.initials: X
authors.lastname: Huang
authors.forename: Mao-Zhi
authors.initials: MZ
authors.lastname: Liang
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000097:blood; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood; D001713:Biphenyl Compounds / Q000097:blood; D004791:Enzyme Inhibitors / Q000097:blood; D044950:Flavanones / Q000097:blood; D005960:Glucosides / Q000097:blood; D006569:Hesperidin / Q000097:blood; D006801:Humans; D017705:Lignans / Q000097:blood; D008297:Male; D015394:Molecular Structure; D009153:Mutagens / Q000378:metabolism; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood / Q000188:drug therapy*; D010936:Plant Extracts / Q000378:metabolism / Q000493:pharmacokinetics*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000880:Anthraquinones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D044950:Flavanones; D005960:Glucosides; D017705:Lignans; D009153:Mutagens; D010936:Plant Extracts; C477169:dachengqi decoction; C005498:magnolol; C089997:rheochrysin; D006569:Hesperidin; C027113:chrysophanic acid; C005274:naringin; C020491:rhein