Integration column: Microfluidic high-throughput screening.
Biology has always been a heavily technology limited field. Burgeoning fields such as systems biology require the development and implementation of new technologies, enabling high-throughput and high-fidelity measurements of large systems. Microfluidics promises to fulfil many of the requirements put forth. Here I will discuss the various approaches employed to date for performing high-throughput screening experiments on-chip, encompassing biochemical, biophysical, and cell-based assays.
Maerkl
Sebastian J
SJ
Ecole Polytechnique Fédérale de Lausanne, Institute of Bioengineering, Switzerland. Sebastian.maerkl@epfl.ch
D001681:Biological Assay / Q000295:instrumentation* / Q000639:trends; D018929:Cell Culture Techniques / Q000295:instrumentation* / Q000639:trends; D004867:Equipment Design; D017022:Flow Injection Analysis / Q000295:instrumentation* / Q000639:trends; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000639:trends