title: Computed tomography perfusion assessment of radiation therapy effects on spinal cord hemodynamics.
abstract: OBJECTIVE
  We used computed tomography (CT) perfusion to evaluate the acute and late effect of radiation therapy (RT) on spinal cord (SC) hemodynamics in patients without symptoms of myelopathy. We hypothesized that SC perfusion could be acutely altered during RT.
  
  
  METHODS
  We analyzed neck CT perfusion studies of 36 head-and-neck cancer patients (N1), 16 of whom had previously undergone RT. In a separate group of 6 patients (N2), CT perfusion studies were obtained before RT, after 40 Gy, and after treatment completion.
  
  
  RESULTS
  In the N1 group, SC blood flow (BF), blood volume (BV), mean transit time (MTT), and capillary permeability (CP) maps were not significantly different between RT-treated and RT-naive patients. In the N2 group, BF and CP were significantly increased during treatment compared with the baseline and post-RT studies.
  
  
  CONCLUSIONS
  Radiation therapy of the head and neck may cause transient perturbations of SC perfusion that seem to reverse after treatment. There are no definite chronic effects of RT on SC perfusion observeable at the typical doses administered during treatment of head and neck malignancies.
authors.affiliation: Department of Radiology, Medical University of South Carolina, Charleston, SC, USA. spampin@musc.edu
authors.forename: Maria Vittoria
authors.initials: MV
authors.lastname: Spampinato
authors.forename: Sotirios
authors.initials: S
authors.lastname: Bisdas
authors.forename: Anand K
authors.initials: AK
authors.lastname: Sharma
authors.forename: Daniel
authors.initials: D
authors.lastname: McDonald
authors.forename: Primoz
authors.initials: P
authors.lastname: Strojan
authors.forename: Zoran
authors.initials: Z
authors.lastname: Rumboldt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity / Q000502:physiology / Q000528:radiation effects; D001810:Blood Volume / Q000502:physiology / Q000528:radiation effects; D002199:Capillary Permeability / Q000502:physiology / Q000528:radiation effects; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012039:Regional Blood Flow / Q000502:physiology / Q000528:radiation effects; D013116:Spinal Cord / Q000098:blood supply* / Q000528:radiation effects*; D014057:Tomography, X-Ray Computed / Q000379:methods*