Application of charged single isomer derivatives of cyclodextrins in capillary electrophoresis for chiral analysis.
The review focuses on the role of ionic or ionisable single isomer derivatives (SIDs) of cyclodextrins on the separation of chiral analytes in capillary electrophoresis (CE), covering the period since the year 2000. The advantages of using pure compounds are discussed, as well as the ways to optimise the separations in the context of a rational approach to these techniques. Specific attention is paid to the modulation of the selector-analyte interaction. The advantage due to a detailed knowledge of equilibria occurring in solution during the CE run is underlined, particularly in the case of the presence of metal complexes, as occurs in chiral ligand exchange capillary electrophoresis (CLECE).
Cucinotta
Vincenzo
V
Department of Chemical Sciences, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy. ecucinotta@unict.it
Contino
Annalinda
A
Giuffrida
Alessandro
A
Maccarrone
Giuseppe
G
Messina
Marianna
M
D000838:Anions / Q000737:chemistry; D002412:Cations / Q000737:chemistry; D003505:Cyclodextrins / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods*; D008958:Models, Molecular; D013237:Stereoisomerism
D000838:Anions; D002412:Cations; D003505:Cyclodextrins