Multimethod adherence assessment in children with perinatally acquired HIV-1: the influence of off-schedule dosing in predicting biological markers.
To improve upon adherence assessment in children with HIV, multimethod adherence strategies (pill count, missed doses, off-schedule dosing) were conducted concurrent with viral load and CD4% biomarker assays. Off-schedule dosing predicted both health status markers, while the more common strategies did not. Findings support inclusion of off-schedule dosing concurrent with collection of biomarkers to assess adherence in children with HIV.
Garvie
Patricia A
PA
Department of Behavioral Medicine, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. patti.garvie@stjude.org
Wilkins
Megan L
ML
Kolivas
Elizabeth D
ED
Young
J Christopher
JC
D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D018791:CD4 Lymphocyte Count; D017028:Caregivers; D002648:Child; D003430:Cross-Sectional Studies; D004334:Drug Administration Schedule; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000635:transmission / Q000821:virology; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D007407:Interviews as Topic; D008297:Male; D055118:Medication Adherence; D010349:Patient Compliance / Q000706:statistics & numerical data*; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D019562:Viral Load / Q000502:physiology*
D019380:Anti-HIV Agents