Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis.
The iterative polyketide synthases from the biosynthetic pathways of three enediyne natural products were examined. The results established the all-trans conjugated pentadecaheptanene as the only major product shared by the PKSs. The experiments further revealed some intrinsic differences among the PKSs by demonstrating the formation of different by-products.
Sun
Huihua
H
School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.
Kong
Rong
R
Zhu
Di
D
Lu
Min
M
Ji
Qiang
Q
Liew
Chong Wai
CW
Lescar
Julien
J
Zhong
Guofu
G
Liang
Zhao-Xun
ZX
D001688:Biological Products / Q000096:biosynthesis / Q000737:chemistry; D053281:Enediynes / Q000737:chemistry* / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology*; D015394:Molecular Structure; D048630:Polyketide Synthases / Q000378:metabolism*
D001688:Biological Products; D053281:Enediynes; D048630:Polyketide Synthases