title: [A case of subarachnoid hemorrhage complicated by acquired hemophilia].
abstract: We report a rare case of subarachnoid hemorrhage (SAH) in a man who acquired factor VIII inhibitor and suffered coagulopathy a month after disease onset. Acquired factor VIII inhibitors in patients without hemophilia is a rare disease characterized by severe bleeding as a result of antibody against factor VIII. A 61-year-old male, who had a past history of hypertension, underwent resection for colon cancer at the local hospital. Ten days after surgery he suffered septic shock that required intensive use of antibiotics. Two days after this episode, he had a sudden loss-of-consciousness attack, and was referred to our hospital with the diagnosis of SAH. Emergency angiography revealed a dissecting aneurysm at the right intracranial vertebral artery distal to the origin of the posterior inferior cerebellar artery. The aneurysm was successfully treated with endovascular parent artery occlusion. However, after a placing ventriculo-peritoneal shunt a month later, he developed severe coagulopathy due to acquired factor VIII inhibitor.
authors.affiliation: Department of Neurosurgery, Saitama Red Cross Hospital, Japan.
authors.forename: Ryuta
authors.initials: R
authors.lastname: Saito
authors.forename: Toshie
authors.initials: T
authors.lastname: Takahashi
authors.forename: Hidenori
authors.initials: H
authors.lastname: Endo
authors.forename: Naoto
authors.initials: N
authors.lastname: Kimura
authors.forename: Uichi
authors.initials: U
authors.lastname: Kaneko
mesh_terms: D003110:Colonic Neoplasms / Q000601:surgery; D006467:Hemophilia A / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000601:surgery