Short nucleotide sequences signal spliceosomal binding in nucleic acids.
We have explored the region around the splice sites of the human intron and exons from the exon-intron database (EID) and located a number of short 6-nucleotide and 7-nucleotide sequences that are relatively common in the regions. These short sequences, we expect play an important role in the selection of the appropriate splicing process. We propose that the external signals via short recognition sequences play the deterministic role in the actual splicing process. We have obtained 50 such sequences each from the exon and intron from the beginning and from the ending and noted a number of common features.
Reddy
K Rupa
KR
Department of Biochemistry, University of Hyderabad, Hyderabad 500 046, India.
Mitra
Chanchal K
CK
D001483:Base Sequence; D001665:Binding Sites; D017124:Conserved Sequence; D030541:Databases, Genetic; D005091:Exons / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D009696:Nucleic Acids / Q000235:genetics* / Q000378:metabolism*; D012326:RNA Splicing; D017422:Sequence Analysis, DNA; D017381:Spliceosomes / Q000235:genetics* / Q000378:metabolism*
D009696:Nucleic Acids