title: Nematodetoxic aurovertin-type metabolites from a root-knot nematode parasitic fungus Pochonia chlamydosporia.
abstract: Chemical investigation of one fungal strain P. chlamydosporia YMF 1.00613 isolated from root knots of tobacco infected by Meloidogyne incognita led to the isolation and identification of four aurovertin-type metabolites, which include a new compound, aurovertin I (A1), and three known metabolites, aurovertins E, F and D (A2-A4). Their structures were established by spectroscopic studies such as 1D- and 2D-NMR and MS analysis. Aurovertin I (A1) is the first natural product with an aurovertin skeleton with one less carbon. Compounds A3 and A4 showed the toxicity to the worms of the free-living nematode Panagrellus redivevus with the LC(50) values 88.6 and 41.7 microg/mL at 48 h, respectively. All four aurovertins did not show obvious inhibitory effects on egg hatch of root knot nematode Meloidogyne incognita. The results suggested that the aurovertin-type metabolites produced by P. chlamydosporia might be one of the pathogenic factors involved in the suppression of nematodes.
authors.affiliation: Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming 650091, PR China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Niu
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Wang
authors.forename: Yan-Sheng
authors.initials: YS
authors.lastname: Chu
authors.forename: Hua-Xi
authors.initials: HX
authors.lastname: Xue
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Lu-Xia
authors.initials: LX
authors.lastname: Wei
authors.forename: Ming-He
authors.initials: MH
authors.lastname: Mo
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D001313:Aurovertins / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D006999:Hypocreales / Q000737:chemistry / Q000378:metabolism*; D009348:Nematoda / Q000187:drug effects / Q000502:physiology; D010935:Plant Diseases / Q000469:parasitology; D014026:Nicotiana / Q000469:parasitology; D014431:Tylenchoidea / Q000187:drug effects / Q000382:microbiology*
chemical_list: D000969:Antinematodal Agents; D001313:Aurovertins