title: Homocysteine, fibrinogen and anti-ox-LDL antibody levels as markers of atherosclerosis in prepubertal obese children.
abstract: BACKGROUND
  Homocysteine, fibrinogen and antibodies to oxidised LDL were shown to be important markers of atherosclerosis in adults.
  
  
  OBJECTIVE
  To investigate the levels of these three risk factors in prepubertal obese children.
  
  
  METHODS
  Fasting homocysteine, fibrinogen and antibodies to oxidised LDL, plasma lipids, insulin, HbA1c and blood glucose levels were investigated in 30 prepubertal obese and 28 control children 6-9 years old. Investigations in the obese group were repeated after an oral glucose tolerance test.
  
  
  RESULTS
  Fasting fibrinogen levels of the obese children were found to be significantly higher than those in the controls. Anti-ox-LDL antibody levels increased significantly after an oral glucose tolerance test.
  
  
  CONCLUSIONS
  Fasting fibrinogen and postload ox-LDL levels which could act as important markers of coronary heart disease in later life could also be important risk factors in prepubertal obese children.
authors.affiliation: Department of Pediatrics, Gazi University Faculty of Medicine, Ankara, Turkey. fezgu@gazi.edu.tr
authors.forename: Fatih
authors.initials: F
authors.lastname: Ezgü
authors.forename: Leyla
authors.initials: L
authors.lastname: Tümer
authors.forename: Ferda
authors.initials: F
authors.lastname: Ozbay
authors.forename: Alev
authors.initials: A
authors.lastname: Hasanoglu
authors.forename: Gürsel
authors.initials: G
authors.lastname: Biberoğlu
authors.forename: Cemalettin
authors.initials: C
authors.lastname: Aybay
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis*; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D002648:Child; D003327:Coronary Disease / Q000175:diagnosis; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006442:Glycated Hemoglobin / Q000032:analysis; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D009765:Obesity / Q000097:blood* / Q000150:complications
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D005340:Fibrinogen; D006442:Glycated Hemoglobin; D006710:Homocysteine; D008077:Lipoproteins, LDL; C517652:hemoglobin A1c protein, human; C099252:oxidized low density lipoprotein