title: Engineering the mouse genome to model human disease for drug discovery.
abstract: Genetically engineered mice (GEM) have become invaluable tools for human disease modeling and drug development. Completion of the mouse genome sequence in combination with transgenesis and gene targeting in embryonal stem cells have opened up unprecedented opportunities. Advanced technologies for derivation of GEM models will be introduced and discussed.
authors.affiliation: Ozgene Pty. Ltd., Bentley DC, WA, Australia.
authors.forename: Frank
authors.initials: F
authors.lastname: Koentgen
authors.forename: Gabriele
authors.initials: G
authors.lastname: Suess
authors.forename: Dieter
authors.initials: D
authors.lastname: Naf
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D055808:Drug Discovery; D053595:Embryonic Stem Cells / Q000502:physiology; D055879:Gene Knock-In Techniques; D018390:Gene Targeting / Q000379:methods; D018014:Gene Transfer Techniques; D005818:Genetic Engineering / Q000379:methods; D016678:Genome; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D034622:RNA Interference