title: Current state of coenzyme Q(10) production and its applications.
abstract: Coenzyme Q(10) (CoQ(10)), an obligatory cofactor in the aerobic respiratory electron transfer for energy generation, is formed from the conjugation of a benzoquinone ring with a hydrophobic isoprenoid chain. CoQ(10) is now used as a nutritional supplement because of its antioxidant properties and is beneficial in the treatment of several human diseases when administered orally. Bioprocesses have been developed for the commercial production of CoQ(10) because of its increased demand, and these bioprocesses depend on microbes that produce high levels of CoQ(10) naturally. However, as knowledge of the biosynthetic enzymes and the regulatory mechanisms modulating CoQ(10) production increases, approaches arise for the genetic engineering of CoQ(10) production in Escherichia coli and Agrobacterium tumefaciens. This review focused on approaches for CoQ(10) production, strategies used to engineer CoQ(10) production in microbes, and potential applications of CoQ(10).
authors.affiliation: Department of Chemical Engineering, Konkuk University, Seoul 143-701, South Korea.
authors.forename: Marimuthu
authors.initials: M
authors.lastname: Jeya
authors.forename: Hee-Jung
authors.initials: HJ
authors.lastname: Moon
authors.forename: Jeong-Lim
authors.initials: JL
authors.lastname: Lee
authors.forename: In-Won
authors.initials: IW
authors.lastname: Kim
authors.forename: Jung-Kul
authors.initials: JK
authors.lastname: Lee
mesh_terms: D016960:Agrobacterium tumefaciens / Q000235:genetics / Q000378:metabolism*; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism; D019149:Bioreactors; D019587:Dietary Supplements; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D005285:Fermentation; D005818:Genetic Engineering; D006801:Humans; D007218:Industrial Microbiology; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry
chemical_list: D000975:Antioxidants; D014451:Ubiquinone; C024989:coenzyme Q10