Radioisotopic imaging of neuroinflammation.
Inflammatory responses are closely associated with many neurologic disorders and influence their outcome. In vivo imaging can document events accompanying neuroinflammation, such as changes in blood flow, vascular permeability, tightness of the blood-to-brain barrier, local metabolic activity, and expression of specific molecular targets. Here, we briefly review current methods for imaging neuroinflammation, with special emphasis on nuclear imaging techniques.
Winkeler
Alexandra
A
CEA, I(2)BM, Service Hospitalier Frédéric Joliot, LIME, INSERM U803, 91400 Orsay, France.
Boisgard
Raphaël
R
Martin
Abraham
A
Tavitian
Bertrand
B
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002560:Cerebrovascular Circulation; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007249:Inflammation / Q000473:pathology; D008279:Magnetic Resonance Imaging; D017628:Microglia / Q000000981:diagnostic imaging; D009443:Neuritis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D049268:Positron-Emission Tomography; D011859:Radiography; D015899:Tomography, Emission-Computed, Single-Photon; D014657:Vasculitis / Q000000981:diagnostic imaging