Overcoming inhibition in the spindle checkpoint.
Spindle checkpoint silencing is a critical step during mitosis that initiates chromosome segregation, yet surprisingly little is known about its mechanism. Protein phosphatase I (PP1) was shown recently to be a key player in this process, and in this issue of Genes & Deverlopment, Akiyoshi and colleagues (pp. 2887-2899) identify budding yeast Fin1p as a kinetochore-localized regulator of PP1 activity toward checkpoint targets. Here we review recent mechanistic insights and propose a working model for spindle checkpoint silencing.
Vanoosthuyse
Vincent
V
Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom. vvanoost@staffmail.ed.ac.uk
Hardwick
Kevin G
KG
D015966:Gene Expression Regulation, Fungal; D018386:Kinetochores / Q000378:metabolism; D008954:Models, Biological; D054645:Protein Phosphatase 1 / Q000378:metabolism; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000378:metabolism*; D015003:Yeasts / Q000201:enzymology / Q000235:genetics
D054645:Protein Phosphatase 1