Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children.
Children aged 11 to <24 months received 2 intranasal doses of live attenuated influenza vaccine (LAIV) or placebo, 35+/-7 days apart. Dose 1 was administered concomitantly with a combined measles, mumps, and rubella vaccine (Priorix). Seroresponses to measles and mumps were similar between groups. Compared with placebo, response rates to rubella in LAIV+Priorix recipients were statistically lower at a 15 IU/mL threshold (83.9% vs 78.0%) and the prespecified noninferiority criteria were not met. In a post hoc analysis using an alternate widely accepted threshold of 10 IU/mL, the noninferiority criteria were met (93.4% vs 89.8%). Concomitant administration with Priorix did not affect the overall influenza protection rate of LAIV (78.4% and 63.8% against antigenically similar influenza strains and any strain, respectively).
Lum
Lucy Chai See
LC
Department of Pediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Borja-Tabora
Charissa Fay
CF
Breiman
Robert F
RF
Vesikari
Timo
T
Sablan
Benjamin P
BP
Chay
Oh Moh
OM
Tantracheewathorn
Taweewong
T
Schmitt
Heinz-Josef
HJ
Lau
Yu-Lung
YL
Bowonkiratikachorn
Piyaporn
P
Tam
John S
JS
Lee
Bee Wah
BW
Tan
Kah Kee
KK
Pejcz
Jerzy
J
Cha
Sungho
S
Gutierrez-Brito
Maricruz
M
Kaltenis
Petras
P
Vertruyen
Andre
A
Czajka
Hanna
H
Bojarskas
Jurgis
J
Brooks
W Abdullah
WA
Cheng
Sheau-Mei
SM
Rappaport
Ruth
R
Baker
Sherryl
S
Gruber
William C
WC
Forrest
Bruce D
BD
D000281:Administration, Intranasal; D000914:Antibodies, Viral / Q000097:blood; D004344:Drug Incompatibility; D005260:Female; D006801:Humans; D007223:Infant; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control; D008297:Male; D008457:Measles / Q000517:prevention & control; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000276:immunology*; D009107:Mumps / Q000517:prevention & control; D010919:Placebos / Q000008:administration & dosage; D012409:Rubella / Q000517:prevention & control; D014611:Vaccination / Q000379:methods*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D022542:Measles-Mumps-Rubella Vaccine; D010919:Placebos; D014613:Vaccines, Attenuated; D017778:Vaccines, Combined