title: Ligand-controlled enantioselective [2 + 2] cycloaddition of oxabicyclic alkenes with terminal alkynes using chiral iridium catalysts.
abstract: The first catalytic asymmetric [2 + 2] cycloaddition of oxabicyclic alkenes and terminal alkynes has been developed. This iridium-catalyzed enantioselective [2 + 2] cycloaddition allows the formation of four stereocenters in a single step with excellent enantioselectivity (94-->99% ee).
authors.affiliation: Open Laboratory of Chirotechnology, Institute of Molecular Technology for Drug Discovery and Synthesis, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Bao-Min
authors.initials: BM
authors.lastname: Fan
authors.forename: Xiao-Jiao
authors.initials: XJ
authors.lastname: Li
authors.forename: Fang-Zhi
authors.initials: FZ
authors.lastname: Peng
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Zhang
authors.forename: Albert S C
authors.initials: AS
authors.lastname: Chan
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Shao
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007495:Iridium / Q000737:chemistry*; D008024:Ligands; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000480:Alkynes; D001643:Bridged Bicyclo Compounds; D008024:Ligands; D009942:Organometallic Compounds; D007495:Iridium