Phagocytic activity of alveolar macrophages in the presence of liposomal "biene".
Phagocytic activity of alveolar macrophages isolated from rat bronchoalveolar lavage fluid was studied during their reaction with multilamellar liposomes containing biene (a complex of unsaturated fatty acids). Liposomes with incorporated biene significantly stimulated phagocytic activity of freshly isolated macrophages and primary culture of these cells (judging from the increase in phagocytic index and phagocytic number). A quantitative relationship between the phagocytic number and phagocytic index, on the one hand, and the concentration of liposomal biene, on the other, was detected. The effects of liposomes containing incorporated biene, liposomes of similar composition without biene, and pure biene substance on cell suspension were compared.
Bushmakina
I M
IM
Laboratory of Cell Biophysics and Engineering, Institute of Cell Biophysics and Engineering, National Academy of Sciences of Belarus, Minsk, Belarus. bushm-im@yandex.ru
Drozdova
N I
NI
Martynova
M A
MA
D000818:Animals; D002478:Cells, Cultured; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D008081:Liposomes / Q000737:chemistry / Q000494:pharmacology*; D016676:Macrophages, Alveolar / Q000166:cytology / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects*; D051381:Rats
D005231:Fatty Acids, Unsaturated; D008081:Liposomes