title: Antiviral flavonoids from Mosla scabra.
abstract: An ethanolic extract and ethyl acetate fraction (EFMS) prepared from Mosla scabra showed potential inhibition against influenza viruses. The compounds isolated from EFMS were elucidated to be ursolic acid (1), 5-hydroxy-6,7-dimethoxyflavone (2), 5-hydroxy-7,8-dimethoxyflavone (3), apigenin (4) and acacetin (5) based on their spectral analysis. Compounds 2, 3, 4 and 5 showed significant anti-influenza viruses activities. Compared with ribavirin, EFMS appeared to have similar efficacy against influenza viruses, was considered to be less toxic and may warrant further evaluation as a possible agent for the treatment of influenza.
authors.affiliation: College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, China. wqfyjm@sina.com
authors.forename: Qiaofeng
authors.initials: Q
authors.lastname: Wu
authors.forename: Chenhuan
authors.initials: C
authors.lastname: Yu
authors.forename: Yunliang
authors.initials: Y
authors.lastname: Yan
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Chunchun
authors.initials: C
authors.lastname: Zhang
authors.forename: Xinxin
authors.initials: X
authors.lastname: Wen
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D047310:Apigenin / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D004285:Dogs; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D009980:Influenza A virus / Q000187:drug effects*; D019686:Lamiaceae / Q000737:chemistry*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000821:virology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D012254:Ribavirin; D014315:Triterpenes / Q000302:isolation & purification; D000097245:Ursolic Acid
chemical_list: D000998:Antiviral Agents; D047310:Apigenin; D047309:Flavones; D010936:Plant Extracts; D012254:Ribavirin; D014315:Triterpenes; D000097245:Ursolic Acid; C023717:acacetin