title: Proteomic analysis of mitochondria in Raji cells following exposure to radiation: implications for radiotherapy response.
abstract: Radioresistance represents a major obstacle to a successful outcome for the treatment of non-Hodgkin's lymphoma (NHL). Here we performed a global differential proteome analysis of the mitochondria in Raji cells exposed to radiation. The results showed that 23 differentially expressed proteins were identified. Furthermore, GAPDH, RECQL4, MKI67, and ATAD3B could serve as potential biomarkers of radioresistance.
authors.affiliation: Department of Hematology, Provincial Hospital Affiliated to Shandong University, Shandong, China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Jiang
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaosheng
authors.initials: X
authors.lastname: Fang
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism / Q000528:radiation effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000528:radiation effects; D019295:Computational Biology; D005434:Flow Cytometry; D015972:Gene Expression Regulation, Neoplastic / Q000528:radiation effects; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D008928:Mitochondria / Q000378:metabolism* / Q000528:radiation effects*; D020543:Proteome / Q000528:radiation effects*; D040901:Proteomics / Q000379:methods; D011878:Radiotherapy; D015203:Reproducibility of Results
chemical_list: D014408:Biomarkers, Tumor; D020543:Proteome