Study of antimycotic activity of lyticase.
Laboratory studies of lyticase (enzymatic drug) as an antimycotic agent were carried out. The enzyme reduced optical density of Candida albicans test culture, inhibited adhesion of yeast-like fungi on vaginal epitheliocytes, stimulated the formation of germinative tubes, and made Candida albicans more available for phagocytosis.
Sachivkina
N P
NP
Department of Microbiology and Virology, Russian University of Peoples' Friendship, Moscow, Russia.
Kravtsov
E G
EG
Vasilyeva
E A
EA
Anokhina
I V
IV
Dalin
M V
MV
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects* / Q000502:physiology; D002177:Candidiasis / Q000188:drug therapy; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000382:microbiology; D005260:Female; D004693:Glucan Endo-1,3-beta-D-Glucosidase / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D009097:Multienzyme Complexes / Q000494:pharmacology* / Q000627:therapeutic use; D010447:Peptide Hydrolases / Q000494:pharmacology* / Q000627:therapeutic use; D010587:Phagocytosis; D014621:Vagina / Q000166:cytology
D000935:Antifungal Agents; D009097:Multienzyme Complexes; C025310:lyticase; D004693:Glucan Endo-1,3-beta-D-Glucosidase; D010447:Peptide Hydrolases