title: Extracorporeal shock wave treatment in ischemic tissues: what is the appropriate number of shock wave impulses?
abstract: The dose-dependent effect of extracorporeal shock wave technology (ESWT) was evaluated using a murine skin flap model. Thirty-six Sprague-Dawley rats were divided into six groups (ESWT groups 1 through 5 and a control group). After surgery, shock wave impulses doses were administered: 200 (group 1), 500 (group 2), 1500 (group 3), 2500 (group 4), 5000 (group 5), and 0 (control group 6). Flap viability was evaluated on day 7. Overall, significantly smaller percentages of necrotic zones were observed in groups 2, 3, and 4 compared with groups 1, 5, and the control group ( P < 0.05). ESWT treatment with 200 impulses was found to be ineffective. ESWT treatment of 5000 impulses resulted in a significant increase in the percentage of necrosis compared with other ESWT groups ( P < 0.05). However, ESWT treatments between 500 and 2500 impulses at 0.11 mJ/mm (2) enhanced epigastric skin flap survival significantly.
authors.affiliation: Medical University of Innsbruck, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Florian
authors.initials: F
authors.lastname: Kamelger
authors.forename: Markus
authors.initials: M
authors.lastname: Oehlbauer
authors.forename: Hildegunde
authors.initials: H
authors.lastname: Piza-Katzer
authors.forename: Romed
authors.initials: R
authors.lastname: Meirer
mesh_terms: D000818:Animals; D019074:Epigastric Arteries; D006085:Graft Survival; D019220:High-Energy Shock Waves / Q000627:therapeutic use*; D007511:Ischemia / Q000209:etiology / Q000628:therapy*; D008297:Male; D009336:Necrosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D018709:Statistics, Nonparametric; D013524:Surgical Flaps / Q000098:blood supply*