title: Conjunctival melanoma arising from primary acquired melanosis in a patient with neurofibromatosis type I.
abstract: OBJECTIVE
  To describe a case of conjunctival malignant melanoma (MM) arising from primary acquired melanosis in a patient with neurofibromatosis type 1 (NF-1).
  
  
  METHODS
  Case report and literature review.
  
  
  RESULTS
  A 66-year-old woman with a history of NF-1 presented with extensive pigmentation of the left bulbar conjunctiva. Conjunctival biopsies demonstrated MM arising from primary acquired melanosis with atypia. Two excision and cryotherapy procedures did not completely eradicate the conjunctival pigment, which was then treated with topical mitomycin C. Subsequent biopsies and clinical examinations have revealed no remaining tumor.
  
  
  CONCLUSIONS
  Conjunctival MM is uncommon in patients with NF-1 and can be successfully treated with excision, cryotherapy, and topical mitomycin C.
authors.affiliation: Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard School of Medicine, Boston, MA 02114, USA.
authors.forename: Rebecca C
authors.initials: RC
authors.lastname: Stacy
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Kenyon
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Jakobiec
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Colby
mesh_terms: D000368:Aged; D003230:Conjunctival Neoplasms / Q000473:pathology* / Q000601:surgery; D017679:Cryotherapy; D005260:Female; D006801:Humans; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D008548:Melanosis / Q000473:pathology*; D009456:Neurofibromatosis 1 / Q000473:pathology*