title: Successful living donor liver transplantation for severe hepatic GVHD histologically resembling autoimmune hepatitis after bone marrow transplantation from the same sibling donor.
abstract: A 30-year-old woman developed severe liver dysfunction 1 year after bone marrow transplantation (BMT) from an HLA-identical sibling donor for B lymphoblastic leukemia (B-ALL) during the tapering of cyclosporin A. The histologic picture resembled autoimmune hepatitis (AIH), although neither autoantibody nor hypergammaglobulinemia was detected. She entered hepatic coma, and underwent living donor liver transplantation from the same donor on day 421 after BMT. She is well 18 months after the procedure, showing normal liver function and hematopoiesis. AIH-like hepatic graft-versus-host disease (GVHD) has not been documented. This patient is the second case of living donor liver transplantation for hepatic GVHD from the same donor.
authors.affiliation: Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital, Kobe, Japan.
authors.forename: Minako
authors.initials: M
authors.lastname: Mori
authors.forename: Sumie
authors.initials: S
authors.lastname: Tabata
authors.forename: Hisako
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Daichi
authors.initials: D
authors.lastname: Inoue
authors.forename: Takaharu
authors.initials: T
authors.lastname: Kimura
authors.forename: Sonoko
authors.initials: S
authors.lastname: Shimoji
authors.forename: Yuya
authors.initials: Y
authors.lastname: Nagai
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Togami
authors.forename: Kiminari
authors.initials: K
authors.lastname: Itoh
authors.forename: Akiko
authors.initials: A
authors.lastname: Matsushita
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nagai
authors.forename: Eiji
authors.initials: E
authors.lastname: Ikeda
authors.forename: Naoya
authors.initials: N
authors.lastname: Kimoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Uryuhara
authors.forename: Satoru
authors.initials: S
authors.lastname: Kaihara
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Imai
authors.forename: Masafumi
authors.initials: M
authors.lastname: Itoh
authors.forename: Takayuki
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D001706:Biopsy; D016026:Bone Marrow Transplantation / Q000379:methods*; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology* / Q000628:therapy; D006680:HLA Antigens / Q000737:chemistry; D006410:Hematopoiesis; D019693:Hepatitis, Autoimmune / Q000209:etiology / Q000276:immunology*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology; D016130:Immunophenotyping; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015456:Leukemia, Biphenotypic, Acute / Q000150:complications / Q000628:therapy; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors
chemical_list: D006680:HLA Antigens; D007166:Immunosuppressive Agents