title: Maternal haemorrhage.
abstract: Maternal haemorrhage is the leading cause of preventable maternal death worldwide and encompasses antepartum, intrapartum, and postpartum bleeding. This review highlights factors that predispose to severe bleeding, its management, and the most recent treatment and guidelines. Advances in obstetric care have provided physicians with the diagnostic tools to detect, anticipate, and prevent severe life-threatening maternal haemorrhage in most patients who have had prenatal care. In an optimal setting, patients at high risk for haemorrhage are referred to tertiary care centres where multidisciplinary teams are prepared to care for and deal with known potential complications. However, even with the best prenatal care, unexpected haemorrhage occurs. The first step in management is stabilization of haemodynamic status, which involves securing large bore i.v. access, invasive monitoring, and aggressive fluid management and transfusion therapy. Care for the patient with maternal bleeding should follow an algorithm that goes through a rapid and successive sequence of medical and surgical approaches to stem bleeding and decrease morbidity and mortality. With the addition of potent uterotonic agents and the advent of minimally invasive interventional radiological techniques such as angiographic embolization and arterial ligation, definitive yet conservative management is now possible in an attempt to avoid hysterectomy in patients with severe peripartum bleeding. If these interventions are inadequate to control the bleeding, the decision to proceed to hysterectomy must be made expeditiously. Recombinant factor VIIa is a relatively new treatment that could prove useful for severe coagulopathy and intractable bleeding.
authors.affiliation: SUNY Downstate Medical Center, 450 Clarkson Ave., Box 6, Brooklyn, NY 11203, USA. menachem.walfish@downstate.edu
authors.forename: M
authors.initials: M
authors.lastname: Walfish
authors.forename: A
authors.initials: A
authors.lastname: Neuman
authors.forename: D
authors.initials: D
authors.lastname: Wlody
mesh_terms: D015942:Factor VIIa / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010922:Placenta Diseases / Q000628:therapy; D006473:Postpartum Hemorrhage / Q000209:etiology / Q000628:therapy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy; D011994:Recombinant Proteins / Q000627:therapeutic use; D012307:Risk Factors; D014592:Uterine Hemorrhage / Q000209:etiology* / Q000628:therapy
chemical_list: D011994:Recombinant Proteins; D015942:Factor VIIa