title: A novel method for patient exit and entrance dose prediction based on water equivalent path length measured with an amorphous silicon electronic portal imaging device.
abstract: In vivo dosimetry is one of the quality assurance tools used in radiotherapy to monitor the dose delivered to the patient. Electronic portal imaging device (EPID) images for a set of solid water phantoms of varying thicknesses were acquired and the data fitted onto a quadratic equation, which relates the reduction in photon beam intensity to the attenuation coefficient and material thickness at a reference condition. The quadratic model is used to convert the measured grey scale value into water equivalent path length (EPL) at each pixel for any material imaged by the detector. For any other non-reference conditions, scatter, field size and MU variation effects on the image were corrected by relative measurements using an ionization chamber and an EPID. The 2D EPL is linked to the percentage exit dose table, for different thicknesses and field sizes, thereby converting the plane pixel values at each point into a 2D dose map. The off-axis ratio is corrected using envelope and boundary profiles generated from the treatment planning system (TPS). The method requires field size, monitor unit and source-to-surface distance (SSD) as clinical input parameters to predict the exit dose, which is then used to determine the entrance dose. The measured pixel dose maps were compared with calculated doses from TPS for both entrance and exit depth of phantom. The gamma index at 3% dose difference (DD) and 3 mm distance to agreement (DTA) resulted in an average of 97% passing for the square fields of 5, 10, 15 and 20 cm. The exit dose EPID dose distributions predicted by the algorithm were in better agreement with TPS-calculated doses than phantom entrance dose distributions.
authors.affiliation: Radiotherapy Physics, Department of Clinical Physics and Bioengineering, Beatson West of Scotland Cancer Center, NHS Greater Glasgow & Clyde, 1053 Great Western Road, Glasgow, G12 0YN, UK. kavuma.awusi@ggc.scot.nhs.uk
authors.forename: Awusi
authors.initials: A
authors.lastname: Kavuma
authors.forename: Martin
authors.initials: M
authors.lastname: Glegg
authors.forename: Mohamed
authors.initials: M
authors.lastname: Metwaly
authors.forename: Garry
authors.initials: G
authors.lastname: Currie
authors.forename: Alex
authors.initials: A
authors.lastname: Elliott
mesh_terms: D000465:Algorithms; D001842:Bone and Bones / Q000528:radiation effects; D008168:Lung / Q000528:radiation effects; D019047:Phantoms, Imaging; D017785:Photons; D011874:Radiometry / Q000379:methods*; D011878:Radiotherapy / Q000295:instrumentation / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D012542:Scattering, Radiation; D012825:Silicon; D014867:Water / Q000737:chemistry*
chemical_list: D014867:Water; D012825:Silicon