title: New isoprenylated 2-arylbenzofurans and pancreatic lipase inhibitory constituents from Artocarpus nitidus.
abstract: Two new isoprenylated 2-arylbenzofurans, artonitidin A (=(2'R)-2',3'-dihydro-2'-(1-hydroxy-1-methylethyl)-5',7-bis(3-methylbut-2-en-1-yl)-2,4'-bi-1-benzofuran-6,6'-diol; and artonitidin B (=5-[6-hydroxy-7-(3-methylbut-2-en-1-yl)-1-benzofuran-2-yl]-4-(3-methylbut-2-en-1-yl)benzene-1,3-diol; together with 14 known compounds, were isolated from the stems of Artocarpus nitidus Trec. The structures were elucidated by spectroscopic methods. Norartocarpin, cudraflavone C, brosimone I, artotonkin, albanin A, and artopetelin M showed inhibitory effects on pancreatic lipase with IC(50) values ranging from 1.8+/-0.1 to 63.8+/-3.6 microM.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, P. R. China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhao
authors.forename: Gui-Rui
authors.initials: GR
authors.lastname: Yan
authors.forename: Sheng-Li
authors.initials: SL
authors.lastname: Pan
authors.forename: He-Yao
authors.initials: HY
authors.lastname: Wang
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Hou
mesh_terms: D031622:Artocarpus / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008049:Lipase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018547:Plant Stems / Q000737:chemistry; D054876:Prenylation
chemical_list: C547373:2',3'-dihydro-2'-(1-hydroxy-1-methylethyl)-5',7-bis(3-methylbut-2-en-1-yl)-2,4'-bi-1-benzofuran-6,6'-diol; C547374:5-(6-hydroxy-7-(3-methylbut-2-en-1-yl)-1-benzofuran-2-yl)-4-(3-methylbut-2-en-1-yl)benzene-1,3-diol; D001572:Benzofurans; D008049:Lipase