Altered open field behavior in rats induced by acute administration of 3-nitropropionic acid: possible glutamatergic and dopaminergic involvement.
3-nitropropionic acid (3-NP), a substance used for modelling Huntington's disease, was given to male Wistar rats in a single 20 mg/kg b.w. dose, and the resulting behavioral alterations in spontaneous locomotor activity were measured after 30 minutes. To detect the involvement of neurotransmitter systems in this immediate effect, the NMDA antagonist MK-801 (0.8 mg/kg); as well as an agonist, quinpirole (QP, 5 mg/kg) and an antagonist, sulpiride (SP, 80 mg/kg) of the dopamine D2 receptors, were given before 3-NP to separate groups of rats. Controls were given saline. All substances were injected ip. 3-NP decreased the rats' locomotor, especially vertical, activity, whereas local activity was increased. Based on the further changes of 3-NP effects in the combination groups it could be concluded that dopaminergic rather than glutamatergic mechanisms were possibly involved in the acute behavioral effect of 3-NP.
Lukács
Anita
A
University of Szeged Department of Public Health Szeged Hungary.
Szabó
Andrea
A
Papp
A
A
Vezér
Tünde
T
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D004195:Disease Models, Animal; D016291:Dizocilpine Maleate / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D018683:Excitatory Amino Acid Agents / Q000494:pharmacology; D006816:Huntington Disease / Q000503:physiopathology; D008297:Male; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors; D009574:Nitro Compounds / Q000494:pharmacology*; D011422:Propionates / Q000494:pharmacology*; D019257:Quinpirole / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000819:agonists; D017470:Receptors, Glutamate / Q000187:drug effects* / Q000502:physiology; D013469:Sulpiride / Q000494:pharmacology
D015259:Dopamine Agents; D065127:Dopamine D2 Receptor Antagonists; D018683:Excitatory Amino Acid Agents; D009574:Nitro Compounds; D011422:Propionates; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D017470:Receptors, Glutamate; D019257:Quinpirole; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate; D013469:Sulpiride; C015392:3-nitropropionic acid