An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging.
An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[(18)F]fluororibose, a novel [(18)F]-fluorinated sugar suitable for positron emission tomography (PET) applications.
Onega
Mayca
M
University of St Andrews, School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife, UKKY16 9ST. do1@st-andrews.ac.uk.
Domarkas
Juozas
J
Deng
Hai
H
Schweiger
Lutz F
LF
Smith
Timothy A D
TA
Welch
Andrew E
AE
Plisson
Christophe
C
Gee
Antony D
AD
O'Hagan
David
D
D001426:Bacterial Proteins / Q000378:metabolism*; D055162:Biocatalysis; D045744:Cell Line, Tumor; D005462:Fluorine Radioisotopes / Q000737:chemistry; D054879:Halogenation; D006801:Humans; D009699:N-Glycosyl Hydrolases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D049268:Positron-Emission Tomography; D012266:Ribose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
C547238:5-deoxy-5-(18F)fluororibose; D001426:Bacterial Proteins; D005462:Fluorine Radioisotopes; D012266:Ribose; D010088:Oxidoreductases; C495766:fluorinase; D009699:N-Glycosyl Hydrolases