title: Clavispora lusitaniae and Chaetomium atrobrunneum as rare agents of cutaneous infection.
abstract: We describe the first case of cutaneous infection caused by Chaetomium atrobrunneum and Clavispora lusitaniae in a one-and-a-half-year-old boy with acute and severe inflammation around his left eyelid. He presented to our outpatient center with a 6-day history and previously ineffective antibacterial therapy. Scanning electron microscopy (SEM) revealed hyphae and spores were on the surface of the crusty exudates and also penetrated into it, and the microbiology study further showed their characteristic cultural features. Fungal isolates were identified by the amplification and sequencing of the 26S RNA gene and of the ITS region, as C. lusitaniae and C. atrobrunneum. Up until now, most known clinical records of these rare species have shown them as agents of deep mycosis. Due to the emergency situation, medications were administered promptly and confirmed by subsequent fungal identification and successful therapeutic outcome. This article illustrates the importance of recognizing fungal infections, especially those caused by uncommon pathogens. Limitations in the routine identification procedures and therapeutic options of this emerging opportunistic agent are also discussed in this report.
authors.affiliation: Department of Dermatology, Sichuan University West China Hospital, Chengdu, China. dr.zhanghao@126.com
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Yuping
authors.initials: Y
authors.lastname: Ran
authors.forename: Dongming
authors.initials: D
authors.lastname: Li
authors.forename: Yongfang
authors.initials: Y
authors.lastname: Liu
authors.forename: Yun
authors.initials: Y
authors.lastname: Xiang
authors.forename: Ruifeng
authors.initials: R
authors.lastname: Zhang
authors.forename: Yaling
authors.initials: Y
authors.lastname: Dai
mesh_terms: D001762:Blepharitis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D002597:Chaetomium / Q000235:genetics / Q000302:isolation & purification*; D021903:DNA, Ribosomal Spacer / Q000235:genetics; D003881:Dermatomycoses / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D003937:Diagnosis, Differential; D006801:Humans; D007223:Infant; D008297:Male; D012331:RNA, Fungal / Q000235:genetics; D012335:RNA, Ribosomal / Q000235:genetics; D004718:Saccharomycetales / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D021903:DNA, Ribosomal Spacer; D012331:RNA, Fungal; D012335:RNA, Ribosomal; C065096:RNA, ribosomal, 26S