Evaluation of healing prosthetic materials polyester mesh resorbable film and collagen elastin matrix /polypropylene used in rabbits abdominal wall defects.
OBJECTIVE
To compare polyester with absorbable layer prosthesis with collagen-elastin/polypropylene prosthesis in the repair of abdominal wall defects.


METHODS
The 16 studied rabbits were divided in groups A and B (euthanized on the 30th and 60th days, after the implant of the mesh). The animals underwent laparotomy and received a 2 cm wall 'defect' on each side of the Alba linea. The repair was made with the suture of a polyester mesh with absorbable film on the left side of the Alba Linea and with collagen-elastin/polypropylene mesh on the right side. Adherences were classified according to Nair Score and microscopic evaluation observing types I and III collagen formation and other immunohistochemical analyses.


RESULTS
There were no significant differences in adhesion formation. The collagen type I showed higher deposition in polyester with absorbable layer. In group B, the difference between the meshes was significant, with higher collagen III deposition in polyester with absorbable layer (60 masculine P.O.). About the metalloproteinases, the presence of MMP -1 and MMP-8 were about the same; the expression of MMP-13 increased near to the 60th day.


CONCLUSIONS
There is no significant difference between the two meshes in adhesion formation and immunohistochemical evaluation. The polyester mesh resorbable film presented a higher deposition of collagen.
Schulz
Danielle Duck
DD
Institute of Medical Research, Post-Graduate Program in Principles of Surgery, Curitiba Evangelic University Hospital -Evangelical School of Parana, Curitiba-PR, Brazil. ipem@evangelico.org.br
Czeczko
Nicolau Gregori
NG
Malafaia
Osvado
O
Schulz
Gustavo Justo
GJ
Czeczko
Leticia Elizabeth A
LE
Garcia
Larissa Santin
LS
Dietz
Ulrich Andreas
UA
D034861:Abdominal Wall / Q000601:surgery*; D020341:Absorbable Implants; D000704:Analysis of Variance; D000818:Animals; D003094:Collagen / Q000032:analysis; D024042:Collagen Type I / Q000032:analysis; D024061:Collagen Type III / Q000032:analysis; D004549:Elastin; D005260:Female; D008422:Materials Testing; D053509:Matrix Metalloproteinase 13 / Q000032:analysis; D023421:Models, Animal; D011091:Polyesters; D011126:Polypropylenes; D011817:Rabbits; D018709:Statistics, Nonparametric; D013526:Surgical Mesh / Q000009:adverse effects* / Q000145:classification; D000267:Tissue Adhesions / Q000473:pathology; D014945:Wound Healing / Q000502:physiology*
D024042:Collagen Type I; D024061:Collagen Type III; D011091:Polyesters; D011126:Polypropylenes; D003094:Collagen; D004549:Elastin; D053509:Matrix Metalloproteinase 13