Vehicle influence on potassium replacement effectiveness in hypokalemic rats.
BACKGROUND
Patients who undergo cardiac surgery are commonly treated with diuretic therapy for the management of volume overload. The concern of hypokalemia important in the adult population submitted to cardiac surgery has been described. Intravenous potassium (K+) replacement dilution is only recommended with sodium chloride 0.9% solution (SF0.9%), likely due to the putative effects of glucose solution 5% (SG5%) on insulin secretion, which influence K+ replacement quality. However, it is not yet experimentally proved the influence of SF0.9% and SG5% on K+ replacement quality.


OBJECTIVE
To evaluate the effects of different vehicles of K+ replacement on blood K+ levels in furosemide hypokalemic rats.


METHODS
Male Wistar rats divided into four groups: K++SF, K++SG, SF and SG. Jugular vein was cannulation for K+ replacement and femoral vein was cannulated for blood analysis were performed. Furosemide (50mg/kg) was injected S.C. to induce hypokalemia. It was analyzed potassium plasmatic levels 24 hours before furosemide injection, 24 hours after furosemide injection and 30 minutes after post-replacement.


RESULTS
There was no significative difference in blood K+ levels when compared to the basal values (pre-furosemide) in all groups. However, the levels [K+] returned to baseline in both groups receiving K++SF or K++SG, which was not observed in groups receiving only SF and SG. Only K+SF presented increased after K+ replacement (P<0.05).


CONCLUSIONS
K+ replacement diluted both in SF and SG did not affect blood K+ levels in rats.
Petenusso
Márcio
M
Department of Physiology, ABC Medical School, Santo André, SP, Brazil.
Valenti
Vitor Engrácia
VE
Abreu
Luiz Carlos de
LC
Colombari
Eduardo
E
Fonseca
Fernando Luiz Affonso
FL
Sato
Monica Akemi
MA
D000818:Animals; D004195:Disease Models, Animal; D005665:Furosemide / Q000008:administration & dosage*; D005947:Glucose / Q000008:administration & dosage*; D007008:Hypokalemia / Q000139:chemically induced* / Q000378:metabolism; D008297:Male; D014677:Pharmaceutical Vehicles / Q000008:administration & dosage* / Q000145:classification; D011188:Potassium / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000008:administration & dosage*; D013997:Time Factors
D014677:Pharmaceutical Vehicles; D012965:Sodium Chloride; D005665:Furosemide; D005947:Glucose; D011188:Potassium