title: Fear of falling has greater influence than other aspects of gait disorders on quality of life in patients with Parkinson's disease.
abstract: We assessed the influence of gait disorders (GD) on quality of life (QOL) in Parkinson's disease (PD). In a survey including the PDQ-39 and a new 8-item questionnaire of GD (8-QGD), 491 PD patients estimated their gait at the worst state, the effect of their GD on activities of daily living, compared the severity of GD with the other PD symptoms, evaluated the occurrence of freezing of gait (FOG), levodopa-resistant FOG, falls, activity limitation due to fear of falling (FOF), and the occurrence of injuries. Significant differences in PDQ-39 scores were found between three groups of patients divided with respect to the severity of GD. Linear multiple regression analysis showed that FOF had the highest impact on PDQ-39 scores (r=0.32, p<0.001). These results confirm that GD have a substantial impact upon the QOL in PD and suggest that FOF plays a major role in QOL deterioration.
authors.affiliation: Department of Neurology, 1st Medical Faculty and General Teaching Hospital, Charles University, Prague, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Brozova
authors.forename: Jan
authors.initials: J
authors.lastname: Stochl
authors.forename: Jan
authors.initials: J
authors.lastname: Roth
authors.forename: Evzen
authors.initials: E
authors.lastname: Ruzicka
mesh_terms: D000058:Accidental Falls; D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005239:Fear / Q000523:psychology*; D005260:Female; D020233:Gait Disorders, Neurologic / Q000503:physiopathology / Q000523:psychology*; D006304:Health Status; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology / Q000523:psychology*; D011788:Quality of Life; D012944:Social Support; D011795:Surveys and Questionnaires