Stolonoxides E and F, cytotoxic metabolites from the marine ascidian Stolonica socialis.
Two new members of the stolonoxide family, stolonoxides E (1) and F (2), were isolated from samples of the marine ascidian Stolonica socialis collected in Cádiz (Spain). Their structures were determined by a combination of techniques, including (+)-HRESIMS, 1D and 2D NMR spectroscopy, and comparison with published data for the structurally related stolonoxides A-D (3-6). Both compounds displayed cytotoxicity against a panel of three human tumor cell lines.
Reyes
Fernando
F
Medicinal Chemistry Department, PharmaMar S.A.U., Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770-Colmenar Viejo, Madrid, Spain. jfreyes@pharmamar.com
Rodríguez-Acebes
Raquel
R
Fernández
Rogelio
R
Bueno
Santiago
S
Francesch
Andrés
A
Cuevas
Carmen
C
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004148:Dioxolanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014561:Urochordata / Q000737:chemistry*
D000970:Antineoplastic Agents; D004148:Dioxolanes; D005663:Furans; C546849:stolonoxide E