title: The effect of radiofrequency ablation on different organs: ex vivo and in vivo comparative studies.
abstract: OBJECTIVE
  The purposes of this study are to evaluate the ex vivo and in vivo efficacy of radiofrequency ablation (RFA) on different porcine tissues by the ablation of three different sites simultaneously.
  
  
  METHODS
  A multichannel RFA system, enables three separate tumors to be ablated simultaneously, was used. RFA procedures were applied to normal porcine liver, kidney, and muscle together ex vivo (n=12) and in vivo (n=17). Pre-impedances, defined as baseline systemic impedances of tissues before beginning RFA, and the areas of ablation zones were measured and compared.
  
  
  RESULTS
  The areas of ablation zones among three organs had a significant difference in decreasing order as follows: liver, muscle, and kidney in the ex vivo study (p=0.001); muscle, liver, and kidney in the in vivo study (p<0.0001). The areas of ablation zones between ex vivo and in vivo had a significant difference in the liver and muscle (each p<0.05). There was no significant correlation between the areas of ablation zones and pre-impedances in both studies.
  
  
  CONCLUSIONS
  Renal RFA produced the smallest ablation zone in both in vivo and ex vivo studies. Muscular RFA demonstrated the largest ablation zone in the in vivo study, and hepatic RFA showed the largest ablation zone in the ex vivo study. This variability in the tissues should be considered for performing an optimized RFA for each organ site.
authors.affiliation: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-Ku, Seoul 135-710, Republic of Korea.
authors.forename: Yoo Na
authors.initials: YN
authors.lastname: Kim
authors.forename: Hyunchul
authors.initials: H
authors.lastname: Rhim
authors.forename: Dongil
authors.initials: D
authors.lastname: Choi
authors.forename: Young-sun
authors.initials: YS
authors.lastname: Kim
authors.forename: Min Woo
authors.initials: MW
authors.lastname: Lee
authors.forename: Ilsoo
authors.initials: I
authors.lastname: Chang
authors.forename: Won Jae
authors.initials: WJ
authors.lastname: Lee
authors.forename: Hyo K
authors.initials: HK
authors.lastname: Lim
mesh_terms: D000818:Animals; D017115:Catheter Ablation / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D004867:Equipment Design; D005260:Female; D066298:In Vitro Techniques; D007668:Kidney / Q000601:surgery*; D008099:Liver / Q000601:surgery*; D018482:Muscle, Skeletal / Q000601:surgery*; D009336:Necrosis; D018709:Statistics, Nonparametric; D013552:Swine