Differences in the distribution of subtypes according to the WHO classification 2008 between Japanese and German patients with refractory anemia according to the FAB classification in myelodysplastic syndromes.
We reported the different clinical features between Japanese and German refractory anemia (RA) patients in FAB classification. We re-analyzed the clinical features by WHO classification revised in 2008. The frequencies of refractory cytopenia with unilineage dysplasia (RCUD) and myelodysplastic syndrome-unclassified (MDS-U) with pancytopenia in Japanese patients were higher than in German patients (p<0.001). Refractory cytopenia with multilineage dysplasia patients showed the most unfavorable prognosis in both countries. The higher frequencies of MDS-U with pancytopenia and RCUD in Japanese patients may influence the different clinical characteristics between Japanese and German FAB-RA patients.
Matsuda
Akira
A
Department of Hematology, Saitama International Medical Center, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, Japan. amatsu@saitama-med.ac.jp
Germing
Ulrich
U
Jinnai
Itsuro
I
Araseki
Kayano
K
Kuendgen
Andrea
A
Strupp
Corinna
C
Iwanaga
Masako
M
Miyazaki
Yasushi
Y
Hata
Tomoko
T
Bessho
Masami
M
Gattermann
Norbert
N
Tomonaga
Masao
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000753:Anemia, Refractory / Q000145:classification* / Q000208:ethnology* / Q000473:pathology; D044466:Asian People; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000145:classification* / Q000208:ethnology* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D014944:World Health Organization; D055815:Young Adult