[Advances in adults' gliomas biology, imaging and treatment].
A better understanding of gliomas biology is now leading to a combined histo-molecular classification of these tumors. In anaplastic gliomas ongoing studies depend on 1p/19q codeletion status and in glioblastomas on MGMT methylation status. Advanced brain tumor imaging elicits a better identification of gliomas evolutive potential of. In low-grade gliomas, the importance of maximal resection and the role of chemotherapy are being increasingly recognized. In anaplastic gliomas, phase III studies have clarified the respective roles of chemotherapy and radiotherapy. In glioblastomas concomitant chemoradiotherapy is the standard. Most targeted therapies, namely anti-EGFR therapies have failed to demonstrate efficacy but anti-angiogenics are promising. The aim of this review is to discuss the main advances in adults' gliomas biology, imaging and treatment.
Ducray
F
F
Université Claude-Bernard-Lyon-I, Service de Neuro-Oncologie, Groupe Hospitalier Est, 8 Avenue Rockefeller, 69373 Lyon, France.
Dutertre
G
G
Ricard
D
D
Gontier
E
E
Idbaih
A
A
Massard
C
C
D000328:Adult; D001254:Astrocytoma / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D001932:Brain Neoplasms / Q000145:classification / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D003131:Combined Modality Therapy / Q000379:methods; D003952:Diagnostic Imaging / Q000379:methods; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D005910:Glioma / Q000145:classification / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D006801:Humans; D009837:Oligodendroglioma / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors
D066246:ErbB Receptors; D040262:Receptors, Vascular Endothelial Growth Factor