title: Adipokine profile and urinary albumin excretion in isolated growth hormone deficiency.
abstract: BACKGROUND
  GH deficiency (GHD) is often associated with cardiovascular risk factors, including abdominal fat accumulation, hypercholesterolemia, and increased C-reactive protein. Despite the presence of these risk factors, adults with congenital lifetime isolated GHD (IGHD) due to an inactivating mutation in the GHRH receptor gene do not have premature atherosclerosis.
  
  
  OBJECTIVE
  The aim was to study the serum levels of adiponectin and leptin (antiatherogenic and atherogenic adipokine, respectively), and the urinary albumin excretion (UAE) in these IGHD individuals.
  
  
  METHODS
  We conducted a cross-sectional study of 20 IGHD individuals (seven males; age, 50.8 +/- 14.6 yr) and 22 control subjects (eight males; age, 49.9 +/- 11.5 yr).
  
  
  METHODS
  Anthropometric factors, body composition, blood pressure, serum adiponectin, leptin, and UAE were measured.
  
  
  RESULTS
  Adiponectin was higher [12.8 (7.1) vs. 9.7 (5) ng/ml; P = 0.041] in IGHD subjects, whereas no difference was observed in leptin [7.3 (6.3) vs. 9.3 (18.7 ng/ml] and UAE [8.6 (13.8) vs. 8.5 (11.1) microg/min].
  
  
  CONCLUSIONS
  Subjects with lifetime untreated IGHD have an adipokine profile with high adiponectin and normal leptin levels that may delay vascular damage and lesions of the renal endothelium.
authors.affiliation: Division of Endocrinology, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA.
authors.forename: Carla R P
authors.initials: CR
authors.lastname: Oliveira
authors.forename: Roberto
authors.initials: R
authors.lastname: Salvatori
authors.forename: Rafael A
authors.initials: RA
authors.lastname: Meneguz-Moreno
authors.forename: Manuel H
authors.initials: MH
authors.lastname: Aguiar-Oliveira
authors.forename: Rossana M C
authors.initials: RM
authors.lastname: Pereira
authors.forename: Eugênia H A
authors.initials: EH
authors.lastname: Valença
authors.forename: Vanessa P
authors.initials: VP
authors.lastname: Araujo
authors.forename: Natália T
authors.initials: NT
authors.lastname: Farias
authors.forename: Débora C R
authors.initials: DC
authors.lastname: Silveira
authors.forename: Jose G H
authors.initials: JG
authors.lastname: Vieira
authors.forename: Jose A S
authors.initials: JA
authors.lastname: Barreto-Filho
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000652:urine*; D003430:Cross-Sectional Studies; D005260:Female; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018013:Receptors, Neuropeptide / Q000235:genetics; D018017:Receptors, Pituitary Hormone-Regulating Hormone / Q000235:genetics; D012044:Regression Analysis
chemical_list: D052242:Adiponectin; D020738:Leptin; D018013:Receptors, Neuropeptide; D018017:Receptors, Pituitary Hormone-Regulating Hormone; D019382:Human Growth Hormone; C048250:somatotropin releasing hormone receptor