Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition.
OBJECTIVE
To examine the relation of amyloid-beta peptide (Abeta) levels in the cerebral cortex with structural brain integrity and cognitive performance in cognitively healthy older people.


METHODS
Longitudinal study from May 22, 1985, through October 15, 2008.


METHODS
Washington University Alzheimer Disease Research Center.


METHODS
A total of 135 individuals aged 65 to 88 years with a Clinical Dementia Rating of 0.


METHODS
The relations between mean cortical carbon 11 ((11)C)-labeled Pittsburgh compound B (PiB) binding potential values, proportional to the density of fibrillar Abeta binding sites in the brain, concurrent regional brain volumes as assessed by magnetic resonance imaging, and both concurrent and longitudinal cognitive performance in multiple domains.


RESULTS
Elevated cerebral Abeta levels, in some cases comparable to those seen in individuals with Alzheimer disease, were observed in 29 participants, who also had smaller regional volumes in the hippocampus, temporal neocortex, anterior cingulate, and posterior cingulate. Concurrent cognitive performance was unrelated to Abeta levels but was related to regional brain volumes with the exception of the caudate. Longitudinal cognitive decline in episodic and working memory and visuospatial ability was associated with elevated Abeta levels and decreased hippocampal volume.


CONCLUSIONS
The in vivo measure of cerebral amyloidosis known as [(11)C]PiB is associated with cross-sectional regionally specific brain atrophy and longitudinal cognitive decline in multiple cognitive domains that occur before the clinical diagnosis of Alzheimer disease. These findings contribute to the understanding of the cognitive and structural consequences of Abeta levels in cognitively healthy older adults.
Storandt
Martha
M
Department of Psychology, School of Arts and Sciences, Washington University, St Louis, Missouri 63108, USA.
Mintun
Mark A
MA
Head
Denise
D
Morris
John C
JC
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000814:Aniline Compounds; D001921:Brain / Q000473:pathology; D002250:Carbon Radioisotopes; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D009929:Organ Size; D010446:Peptide Fragments / Q000378:metabolism; D011485:Protein Binding; D011877:Radionuclide Imaging; D013844:Thiazoles
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D002250:Carbon Radioisotopes; D010446:Peptide Fragments; D013844:Thiazoles