title: Preconditioning and postconditioning reduce hepatic ischemia-reperfusion injury in rats.
abstract: BACKGROUND
  Ischemia-reperfusion injury occurs when ischemic tissues or organs suffer from further functional and structural damage when their blood supply recovers. This study aimed to contrast the protective effects of ischemic preconditioning and ischemic postconditioning in hepatic ischemia-reperfusion injury in rats.
  
  
  METHODS
  Thirty-two healthy male Wistar rats were randomly divided into four groups: sham-operated (SO), ischemia-reperfusion (IR), ischemic preconditioning (I-pre), and ischemic postconditioning (I-post). Blood samples and hepatic tissue were taken from all groups after the experiments.
  
  
  RESULTS
  There were significant differences between the IR, I-pre and I-post groups in alanine aminotransferase and aspartate aminotransferase levels, NF-kappaB p65 expression, apoptosis index and superoxide dismutase activity in hepatic tissue. There were no significant differences between the I-pre and I-post groups.
  
  
  CONCLUSIONS
  Ischemic postconditioning and ischemic preconditioning reduce hepatic ischemia-reperfusion injury, but in clinical practice the former is a more appropriate choice.
authors.affiliation: Department of Hepatobiliary Surgery, Hebei Provincial General Hospital, Shijiazhuang 050051, China. zhangwx12@hotmail.com
authors.forename: Wan-Xing
authors.initials: WX
authors.lastname: Zhang
authors.forename: Wen
authors.initials: W
authors.lastname: Yin
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Lan-Hui
authors.initials: LH
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Bao
authors.forename: Hong-Fang
authors.initials: HF
authors.lastname: Tuo
authors.forename: Li-Fang
authors.initials: LF
authors.lastname: Zhou
authors.forename: Chun-Cheng
authors.initials: CC
authors.lastname: Wang
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D017209:Apoptosis; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D019194:Ischemic Preconditioning; D008099:Liver / Q000098:blood supply* / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism; D051996:Transcription Factor RelA / Q000378:metabolism
chemical_list: D015415:Biomarkers; C498145:Rela protein, rat; D051996:Transcription Factor RelA; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase