Biologic behavior and clinical outcome of 25 dogs with canine appendicular chondrosarcoma treated by amputation: a Veterinary Society of Surgical Oncology retrospective study.
OBJECTIVE
To characterize biologic behavior, clinical outcome, and effect of histologic grade on prognosis for dogs with appendicular chondrosarcoma treated by amputation alone.


METHODS
Case series.


METHODS
Dogs (n=25) with appendicular chondrosarcoma.


METHODS
Medical records were searched to identify dogs with appendicular chondrosarcoma treated by limb amputation alone. Information recorded included signalment, anatomic location, radiographic appearance, and development of metastasis. Histopathologic diagnosis was confirmed and graded (1, 2, or 3). Survival curves were generated by the Kaplan-Meier method and the association between covariates (gender, age, weight, and tumor grade) and survival were evaluated using the univariate proportional hazards model.


RESULTS
Histopathology slides were available for 25 dogs. Rates of pulmonary metastasis were as follows: grade 1-0%, grade 2-31%, and grade 3-50%. Overall median survival time (MST) was 979 days. Age, weight, and sex were not significantly associated with survival (P=.16; .33; and .31, respectively). Survival was significantly associated with tumor grade (P=.008), with dogs with tumor grade of 1, 2, and 3 having MSTs of 6, 2.7, and 0.9 years, respectively.


CONCLUSIONS
Canine appendicular chondrosarcoma can be treated effectively with amputation alone. Low to intermediate grade chondrosarcoma has a good prognosis, whereas high-grade tumors appear to behave aggressively.


CONCLUSIONS
The overall prognosis for appendicular chondrosarcoma is better than that of appendicular osteosarcoma treated by amputation alone or in combination with chemotherapy.
Farese
James P
JP
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0126, USA. faresej@mail.vetmed.ufl.edu
Kirpensteijn
Jolle
J
Kik
Marja
M
Bacon
Nicholas J
NJ
Waltman
Suzanne Shelly
SS
Seguin
Bernard
B
Kent
Michael
M
Liptak
Julius
J
Straw
Rod
R
Chang
Myron N
MN
Jiang
Yang
Y
Withrow
Stephen J
SJ
D000671:Amputation, Surgical / Q000523:psychology / Q000662:veterinary*; D000818:Animals; D001859:Bone Neoplasms / Q000601:surgery / Q000662:veterinary*; D002813:Chondrosarcoma / Q000601:surgery / Q000662:veterinary*; D004283:Dog Diseases / Q000523:psychology / Q000601:surgery*; D004285:Dogs / Q000523:psychology / Q000601:surgery; D005121:Extremities / Q000601:surgery; D005260:Female; D053208:Kaplan-Meier Estimate; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome