title: Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes.
abstract: Quadruplex RNAs are less well understood than their DNA counterparts, yet of potentially high biological relevance. The interactions of several quadruplex-binding ligands with telomeric RNA quadruplexes are reported and compared with their binding to the analogous DNA quadruplexes.
authors.affiliation: Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, UK WC1N 1AX.
authors.forename: Gavin
authors.initials: G
authors.lastname: Collie
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Reszka
authors.forename: Shozeb M
authors.initials: SM
authors.lastname: Haider
authors.forename: Valérie
authors.initials: V
authors.lastname: Gabelica
authors.forename: Gary N
authors.initials: GN
authors.lastname: Parkinson
authors.forename: Stephen
authors.initials: S
authors.lastname: Neidle
mesh_terms: D001665:Binding Sites; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D006801:Humans; D008024:Ligands; D012313:RNA / Q000737:chemistry*; D016615:Telomere / Q000737:chemistry*
chemical_list: D008024:Ligands; D012313:RNA; D004247:DNA