UR-60427, a novel H4 receptor-inverse agonist that shows good efficacy in a rat asthma model.
Alfón
J
J
Palau Pharma SA, Palau-solità i Plegamans, Barcelona, Spain. jalfon@palaupharma.com
Ardanaz
N
N
Gil-Torregrosa
B
B
Fernández
A
A
Balsa
D
D
Carceller
E
E
Gómez
Ll
L
Merlos
M
M
Cortijo
J
J
Morcillo
E
E
Bartrolí
X
X
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D001249:Asthma / Q000188:drug therapy*; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000503:physiopathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D016466:CHO Cells; D002452:Cell Count; D006224:Cricetinae; D003412:Cricetulus; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000494:pharmacology; D017442:Histamine Agonists / Q000494:pharmacology*; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000819:agonists*; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4; D012701:Serotonin / Q000494:pharmacology
D018927:Anti-Asthmatic Agents; D017442:Histamine Agonists; C498828:Hrh4 protein, rat; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4; D012701:Serotonin; D016244:Guanosine 5'-O-(3-Thiotriphosphate)