Robust preparation of novel imidazo[5,1-b][1,3,4]oxadiazoles.
Cyclodehydration of amino acid-derived acyl hydrazide amides to the corresponding oxadiazoles was followed by a second dehydration event, smoothly furnishing the novel imidazo[5,1-b][1,3,4]oxadiazole motif .
Tran
Tuan P
TP
Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA.
Patel
Nandini
N
Samas
Brian
B
Schwarz
Jacob B
JB
D000577:Amides / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D010069:Oxadiazoles / Q000138:chemical synthesis*
D000577:Amides; D000596:Amino Acids; D010069:Oxadiazoles