Synthesis and anti-glioma activity of 25(R)-spirostan-3beta,5alpha,6beta,19-tetrol.
Malignant gliomas are common and aggressive brain tumours in adults. The rapid proliferation and diffuse brain migration are the main obstacles to successful treatment. Here, we show 25(R)-spirostan-3beta,5alpha,6beta,19-tetrol, a polyhydroxy steroid, is capable of suppressing proliferation and migration of C6 malignant glioma cells in a concentration-dependent manner. The compound 25(R)-spirostan-3beta,5alpha,6beta,19-tetrol was synthesised by seven steps starting from diosgenin in 8.55% overall yield. The structures of the synthetic compounds were characterised by infrared (IR), (1)H nuclear magnetic resonance (NMR), (13)C NMR spectra and EA.
Leng
TianDong
T
Department of Pharmacology, Zhong-Shan Medical College, Sun Yat-Sen University, Guangzhou, 74 Zhongshan Road II, Guangzhou 510080, China.
Zhang
JingXia
J
Xie
Jun
J
Zhou
ShuJia
S
Huang
YiJun
Y
Zhou
YueHan
Y
Zhu
WenBo
W
Yan
GuangMei
G
D000328:Adult; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005910:Glioma / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D015394:Molecular Structure; D051381:Rats; D013150:Spirostans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
C549475:25-spirostan-3,5,6,19-tetrol; D000970:Antineoplastic Agents; D013150:Spirostans