Immunogenicity of a psoralen-inactivated dengue virus type 1 vaccine candidate in mice.
We evaluated a novel psoralen-inactivated dengue virus type 1 (DENV-1) vaccine candidate in Mus musculus mice. Mice received intradermal alum or 5 to 10 ng of psoralen-inactivated virus. Anti-DENV-1 neutralizing antibody was detectable in 10/11 mice receiving a 10-ng dose at 90 days. Psoralen-inactivated DENV-1 is immunogenic in mice.
Maves
Ryan C
RC
U.S. Naval Medical Research Center Detachment, Lima, Peru. Ryan.Maves@med.navy.mil
Castillo Oré
Roger M
RM
Porter
Kevin R
KR
Kochel
Tadeusz J
TJ
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000534:Alum Compounds / Q000008:administration & dosage; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D053059:Dengue Vaccines / Q000008:administration & dosage / Q000276:immunology*; D003716:Dengue Virus / Q000187:drug effects* / Q000276:immunology*; D005363:Ficusin / Q000494:pharmacology*; D007271:Injections, Intradermal; D051379:Mice; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology
D000276:Adjuvants, Immunologic; D000534:Alum Compounds; D000890:Anti-Infective Agents; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D053059:Dengue Vaccines; D015164:Vaccines, Inactivated; C041524:aluminum sulfate; D005363:Ficusin