Crystal structure of bucain, a three-fingered toxin from the venom of the Malayan krait (Bungarus candidus).
Bucain, a potent neurotoxin isolated from the venom of the Malayan krait (Bungarus candidus), induces paralysis and death. Its crystal structure has been determined at 2.10 A resolution and based on the molecular topology and hydrophobicity profile is structurally classified as a three-fingered alpha-neurotoxin possessing a positively charged AChR-binding site.
Murakami
M T
MT
Center of Structural & Molecular Biology, Department of Physics, IBILCE/UNESP, São Josë do Rio Preto, SP, Brazil.
Kini
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RM
Arni
R K
RK
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002038:Bungarotoxins / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D017838:Bungarus / Q000378:metabolism*; D003460:Crystallization; D018360:Crystallography, X-Ray; D004546:Elapid Venoms / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D017433:Protein Structure, Secondary; D011950:Receptors, Cholinergic / Q000378:metabolism; D016415:Sequence Alignment; D014118:Toxins, Biological / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism
D002038:Bungarotoxins; D004546:Elapid Venoms; D009498:Neurotoxins; D011950:Receptors, Cholinergic; D014118:Toxins, Biological; C472824:bucain; C419863:bucandin