title: Haplotype association analysis of North American Rheumatoid Arthritis Consortium data using a generalized linear model with regularization.
abstract: The Genetic Analysis Workshop 16 rheumatoid arthritis data include a set of 868 cases and 1194 controls genotyped at 545,080 single-nucleotide polymorphisms (SNPs) from the Illumina 550 k chip. We focus on investigating chromosomes 6 and 18, which have 35,574 and 16,450 SNPs, respectively. Association studies, including single SNP and haplotype-based analyses, were applied to the data on those two chromosomes. Specifically, we conducted a generalized linear model with regularization (rGLM) approach for detecting disease-haplotype association using unphased SNP data. A total of 444 and 43 four-SNP tests were found to be significant at the Bonferroni corrected 5% significance level on chromosome 6 and 18, respectively.
authors.affiliation: Department of Statistics, The Ohio State University, Columbus, Ohio 43210 USA. guowei@stat.osu.edu.
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.forename: Chin-Yuan
authors.initials: CY
authors.lastname: Liang
authors.forename: Shili
authors.initials: S
authors.lastname: Lin