Through the "gatekeeper door": exploiting the active kinase conformation.
Zuccotto
Fabio
F
Department of Chemical Core Technologies, Nerviano Medical Sciences, Oncology, Viale Pasteur 10, Nerviano 20014, Italy. Fabio.Zuccotto@Nervianoms.com
Ardini
Elena
E
Casale
Elena
E
Angiolini
Mauro
M
D015195:Drug Design; D006801:Humans; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D011494:Protein Kinases / Q000737:chemistry* / Q000378:metabolism*; D013379:Substrate Specificity
D047428:Protein Kinase Inhibitors; D011494:Protein Kinases