Predictors of one-year disability and death in Chinese hospitalized women after ischemic stroke.
OBJECTIVE
Women have a worse functional outcome after stroke, but the specific factors associated with a poor outcome in women are rarely reported. This study was designed to investigate the clinical predictors of 1-year disability and death in women after ischemic stroke.


METHODS
Patients with ischemic stroke consecutively registered from March 2002 to July 2007 were followed prospectively for 1 year. Multivariate regression models were employed to analyze predictors of disability (defined as modified Rankin scale score, mRS, 3-5) and death.


RESULTS
A total of 2,774 ischemic stroke patients were included with 1,119 (40.3%) females (mean age 65 +/- 13.5 years). Among female patients, disability (mRS 3-5) is 1.68-fold higher and case fatality is 1.23-fold higher than in men at the 1-year follow-up. Diabetes is an independent predictor of 1-year disability among women (odds ratio, 1.56; 95% confidence interval, CI, 1.01-2.39). In-hospital acute renal failure (hazard ratio, HR, 7.26; 95% CI, 3.47-5.19), suboptimal antiplatelets (HR, 0.55; 95% CI, 0.37-0.83) and antihypertensive therapy (HR, 0.61; 95% CI, 0.42-0.90) are associated with death at 1 year after stroke among women.


CONCLUSIONS
The present study indicates that diabetes, in-hospital acute renal failure, suboptimal antiplatelets and antihypertensive therapy are the possible explanations for the poor 1-year outcome of women hospitalized with ischemic stroke.
Kong
Fan-Yi
FY
Stroke Clinical Research Unit, Department of Neurology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Tao
Wen-Dan
WD
Hao
Zi-Long
ZL
Liu
Ming
M
D058186:Acute Kidney Injury / Q000208:ethnology / Q000401:mortality; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D044466:Asian People / Q000706:statistics & numerical data*; D002545:Brain Ischemia / Q000150:complications / Q000175:diagnosis / Q000208:ethnology* / Q000401:mortality*; D002681:China / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000208:ethnology / Q000401:mortality; D004185:Disability Evaluation; D005260:Female; D017052:Hospital Mortality; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000208:ethnology* / Q000209:etiology / Q000401:mortality*; D013997:Time Factors; D016387:Women's Health / Q000208:ethnology*
D000959:Antihypertensive Agents; D010975:Platelet Aggregation Inhibitors