Factors associated with persistence of arthralgia among Chikungunya virus-infected travellers: report of 42 French cases.
BACKGROUND
In 2005-2006, a major epidemic of CHIKV infection occurred in the Islands of the south-western Indian Ocean, and longstanding manifestations seemed to be more frequent than described before.


OBJECTIVE
To describe the frequency and related factors of late clinical manifestations of CHIKV infection among imported cases living in Aquitaine area, France.


METHODS
All patients recruited through the travel clinic and tropical medicine unit of the University Hospital Centre of Bordeaux with possible CHIKV infection were prospectively recorded, and confirmed cases of CHIKV infection were interviewed 2 years after infection. Factors associated with the persistence of symptoms were determined by multivariate logistic regression.


RESULTS
Among the 29 cases followed, 17 still suffered from arthralgia 2 years after infection, and most of them had never recovered from the initial phase of the condition. The risk of persistent arthralgia tended to be higher among subjects with low educational level, subjects infected in the Reunion Island, and when initial phase lasted 30 days or more and was characterised by a severe pain.


CONCLUSIONS
Consistent with previous studies, our findings showed worsened late manifestations among patients returning from Indian Ocean area. Persistence of symptoms tended to be linked with clinical burden during the acute phase, which can be informative for early recognition and management of patients at risk for developing persistent rheumatic symptoms. Cryoglobulins failed to be identified in seronegative patients with invalidating dengue-like syndrome.
Larrieu
Sophie
S
Cellule Interrégionale d'Epidémiologie d'Aquitaine, Bordeaux, France.
Pouderoux
Nicolas
N
Pistone
Thierry
T
Filleul
Laurent
L
Receveur
Marie-Catherine
MC
Sissoko
Daouda
D
Ezzedine
Khaled
K
Malvy
Denis
D
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018354:Alphavirus Infections / Q000453:epidemiology* / Q000821:virology; D000704:Analysis of Variance; D018771:Arthralgia / Q000453:epidemiology* / Q000821:virology; D002646:Chikungunya virus / Q000302:isolation & purification*; D003450:Cryoglobulins / Q000032:analysis; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D005260:Female; D005602:France / Q000208:ethnology; D006801:Humans; D007195:Indian Ocean Islands / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D014195:Travel / Q000706:statistics & numerical data*
D003450:Cryoglobulins