Cytokine content in lymphoid and white adipose tissues after repeated CpG oligodeoxynucleotide administration in trained rats.
The increased threat of bioterrorism and the emergence of potentially fatal diseases underscores the need to improve treatments for protecting all segments of the human population including military personnel. New methods need to be developed. The ability of oligodeoxynucleotides containing the CpG motif (CpG ODNs) to promote the production of T(H)1-type pro-inflammatory cytokines suggest they might be useful as vaccine adjuvants, but their potential effects during exercise have not been widely studied. Repeated administration of CpG ODN in sedentary rats promoted the production of T(H)1-type pro-inflammatory cytokines in spleen, Peyer's patches and adipose tissues. However, such an increase was not observed in trained rats, suggesting that CpG would not be the best agent for vaccine adjuvants and immunomodulation in intensely trained rats.
Chennaoui
Mounir
M
Département des Environnements Opérationnels, Institut de Recherche Biomédicale des Armées, Antenne Brétigny s/Orge - IMASSA, Brétigny-sur-orge, France. mchennaoui@imassa.fr
Drogou
Catherine
C
Carpentier
Antoine F
AF
Guezennec
Charles-Yannick
CY
Gomez-Merino
Danielle
D
D052436:Adipose Tissue, White / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D016207:Cytokines / Q000032:analysis* / Q000276:immunology; D008297:Male; D009838:Oligodeoxyribonucleotides / Q000276:immunology*; D010581:Peyer's Patches / Q000276:immunology* / Q000378:metabolism; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000276:immunology / Q000378:metabolism; D018417:Th1 Cells / Q000276:immunology
C408982:CPG-oligonucleotide; D016207:Cytokines; D009838:Oligodeoxyribonucleotides