title: Role of neuronal NMDA and non-NMDA glutamate receptors in medial vestibular nucleus in the regulation of respiratory rhythmogenesis in newborn rats in vitro.
abstract: We studied isolated pontobulbospinal preparations from newborn rat brain. In the early postnatal period, the rostral part of the medial vestibular nucleus produces a potent inhibitory effect on neuronal structures of the bulbar respiratory center via the glutamatergic system. Microinjection of L-glutamate (50 mmol/liter) into the rostral part of the vestibular nucleus completely blocks respiratory rhythmogenesis in 0-1-day-old rat pups and reduced the frequency of generation of inspiratory discharges in 2-3-day-old rats from 8.42+/-0.68 to 2.68+/-0.32 min(-1). It was found that the leading role in the mechanism of glutamatergic modulation of the respiratory rhythmogenesis by neurons of the medial vestibular nucleus is played by NMDA and, to a lesser extent, non-NMDA glutamate receptors.
authors.affiliation: Department of Normal Physiology, Samara State Medical University, Russia. tnl@samaramail.ru
authors.forename: N L
authors.initials: NL
authors.lastname: Tyurin
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D018698:Glutamic Acid / Q000008:administration & dosage / Q000494:pharmacology; D005973:Glutamine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology; D010507:Periodicity; D051381:Rats; D017470:Receptors, Glutamate / Q000187:drug effects / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology*; D012119:Respiration / Q000187:drug effects*; D012125:Respiratory Center / Q000187:drug effects / Q000378:metabolism*; D014726:Vestibular Nuclei / Q000187:drug effects / Q000378:metabolism*
chemical_list: D018691:Excitatory Amino Acid Antagonists; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D005973:Glutamine; D018698:Glutamic Acid; D007649:Ketamine; C042626:gamma-glutamylaminomethylsulfonic acid