title: Sarcomatoid renal cell carcinoma in a renal transplant recipient.
abstract: The incidence of transplanted kidneys derived from elderly donors is increasing because of the larger waiting lists and greater age of patients with end-stage renal failure. Compared with young donors, one of the problems is the heightened risk of neoplasm transmission. We report 2 cases of kidney recipients, both of whom developed a sarcomatoid renal cell carcinoma after receiving a kidney transplant from the same 68-year-old male donor, who did not show signs of a neoplasm on a previous abdominal ultrasound or a pretransplant biopsy. The first recipient was a 66-year-old woman who developed a kidney mass with several urologic obstructive complications, tumor dissemination, and death at 9 months after kidney transplantation. The second recipient was a 48-year-old asymptomatic man with normal renal function, who was studied after the results of the first recipient, revealing another renal tumor. Transplant nephrectomy was performed and a peritoneal implant was resected. The patient is alive without evidence of a neoplasm after 18 months. Herein we have discussed the mechanisms of neoplasm transmission in kidney transplantation and possible strategies for its prevention and treatment.
authors.affiliation: Department of Nephrology University Hospital of Albacete, Hnos Falce 37, Albacete 02006, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Llamas
authors.forename: E
authors.initials: E
authors.lastname: Gallego
authors.forename: A
authors.initials: A
authors.lastname: Salinas
authors.forename: J
authors.initials: J
authors.lastname: Virseda
authors.forename: J
authors.initials: J
authors.lastname: Pérez
authors.forename: A
authors.initials: A
authors.lastname: Ortega
authors.forename: S H
authors.initials: SH
authors.lastname: Nam
authors.forename: C
authors.initials: C
authors.lastname: Gómez
mesh_terms: D000328:Adult; D002292:Carcinoma, Renal Cell / Q000473:pathology* / Q000523:psychology / Q000601:surgery*; D003863:Depression / Q000150:complications; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000150:complications / Q000601:surgery; D007680:Kidney Neoplasms / Q000473:pathology* / Q000523:psychology / Q000601:surgery*; D008297:Male; D013119:Spinal Cord Injuries / Q000150:complications; D014019:Tissue Donors; D001750:Urinary Bladder, Neurogenic / Q000209:etiology; D014547:Urinary Diversion