title: A new gene-based association test for genome-wide association studies.
abstract: Genome-wide association studies are widely used today to discover genetic factors that modify the risk of complex diseases. Usually, these methods work in a SNP-by-SNP fashion. We present a gene-based test that can be applied in the context of genome-wide association studies. We compare both strategies, SNP-based and gene-based, in a sample of cases and controls for rheumatoid arthritis.We obtained different results using each strategy. The SNP-based test found the PTPN22 gene while the gene-based test found the PHF19-TRAF1-C5 region. That suggests that no single strategy performs better than another in all cases and that a certain underlying genetic architecture can be delineated more easily with one strategy rather than with another.
authors.affiliation: Unitat de Genomica de Malalties Complexes, Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Barcelona, 08025, Spain. abuil@santpau.cat.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Buil
authors.forename: Angel
authors.initials: A
authors.lastname: Martinez-Perez
authors.forename: Alexandre
authors.initials: A
authors.lastname: Perera-Lluna
authors.forename: Leonor
authors.initials: L
authors.lastname: Rib
authors.forename: Pere
authors.initials: P
authors.lastname: Caminal
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Soria