Silkmoth chorion gene regulation revisited: promoter architecture as a key player.
Regulation of silkmoth chorion genes has long been used as a model system for studying differential gene expression. The large numbers of genes, their overlapping expression patterns and the overall complexity of the system hinted towards an elaborate mechanism for transcriptional control. Recent studies, however, offer evidence of a molecular pathway governed by the interplay between two general transcription factors, CCAAT enhancer binding proteins (C/EBP) and GATA, an architectural protein, high mobility group A and a chromatin remodeller, chromo-helicase/ATPase-DNA binding protein 1. In this review we present a parsimonious model that adequately describes regulation of transcription across all temporally regulated chorion genes, and propose a role for promoter architecture.
Lecanidou
R
R
Molecular Biology Laboratory, Department of Biochemistry and Molecular Biology, National and Kapodistrian University of Athens, Athens, Greece. rlecanid@biol.uoa.gr
Papantonis
A
A
D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors / Q000235:genetics; D012831:Bombyx / Q000235:genetics* / Q000502:physiology; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics; D004527:Egg Proteins / Q000235:genetics*; D005260:Female; D050980:GATA Transcription Factors / Q000235:genetics; D015870:Gene Expression; D017344:Genes, Insect; D024003:HMGA Proteins / Q000235:genetics; D019476:Insect Proteins / Q000235:genetics*; D009707:Nucleosomes / Q000235:genetics; D009866:Oogenesis / Q000235:genetics; D011401:Promoter Regions, Genetic; D015398:Signal Transduction; D014818:Vitellogenesis / Q000235:genetics
D050976:Basic-Leucine Zipper Transcription Factors; D022762:CCAAT-Enhancer-Binding Proteins; D004527:Egg Proteins; D050980:GATA Transcription Factors; D024003:HMGA Proteins; D019476:Insect Proteins; D009707:Nucleosomes; C015753:chorion proteins