Fatty-Acid-induced apoptosis in ehrlich ascites tumor cells.
The unsaturated fatty acids oleic acid and arachidonic acid induced typical apoptosis in Ehrlich ascites tumor cells harvested at the stationary growth phase. Arachidonic acid was a more potent inducer than oleic acid. Apoptosis was induced by concentrations of oleic and arachidonic acids that produced only partial uncoupling of the oxidative phosphorylation. The first symptoms of fatty-acid-induced apoptosis included externalization of phosphatidylserine in the plasma membrane, whereas massive release of cytochrome c from mitochondria to the cytosol followed later on.
Dymkowska
Dorota
D
Nencki Institute of Experimental Biology, Warsaw, Poland.
Szczepanowska
Joanna
J
Wojtczak
Lech
L