title: Highly enantio- and diastereoselective synthesis of alpha-trifluoromethyldihydropyrans using a novel bifunctional piperazine-thiourea catalyst.
abstract: The first enantioselective Michael addition of alpha-cyanoketones to alpha,beta-unsaturated trifluoromethyl ketones using a novel piperazine-thiourea catalyst was described. The resulting alpha-trifluoromethyldihydropyrans were obtained in high yields and with up to 95% ee within a short reaction time. A useful transformation of the chiral adduct was also illustrated.
authors.affiliation: Key Laboratory of Organofluorine Chemistry and Key Laboratory of Modern Synthetic Organic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, 200032, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Chai
authors.forename: Sheng-Li
authors.initials: SL
authors.lastname: Zhao
authors.forename: Ying-Quan
authors.initials: YQ
authors.lastname: Yang
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Wang
authors.forename: Chang-Wu
authors.initials: CW
authors.lastname: Zheng
authors.forename: Yue-Peng
authors.initials: YP
authors.lastname: Cai
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
authors.forename: Shi-Zheng
authors.initials: SZ
authors.lastname: Zhu