Spontaneous and reversible self-assembly of a polypeptide fragment of insulin-like growth factor binding protein-2 into fluorescent nanotubular structures.
In this communication, we report the spontaneous and reversible in vitro self-assembly of a polypeptide fragment derived from the C-terminal domain of Insulin-like Growth Factor Binding Protein (IGFBP-2) into soluble nanotubular structures several micrometres long via a mechanism involving inter-molecular disulfide bonds and exhibiting enhanced fluorescence.
Swain
Monalisa
M
NMR Research Centre, Indian Institute of Science, Bangalore-560012, India.
Thirupathi
R
R
Krishnarjuna
B
B
Eaton
Erin M
EM
Kibbey
Megan M
MM
Rosenzweig
Steven A
SA
Atreya
Hanudatta S
HS
D019943:Amino Acid Substitution; D005456:Fluorescent Dyes / Q000737:chemistry*; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008856:Microscopy, Fluorescence; D016297:Mutagenesis, Site-Directed; D043942:Nanotubes / Q000737:chemistry*; D017510:Protein Folding
D005456:Fluorescent Dyes; D018971:Insulin-Like Growth Factor Binding Protein 2