Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components.
OBJECTIVE
To investigate the effect of severe acute pancreatitis (SAP) on pharmacokinetics of Da-Cheng-Qi Decoction (DCQD) components in rats.


METHODS
Rats were divided into SAP group and sham-operation group as a control group (n = 6). Rhein, chrysophanol, rheochrysidin, magnolol, hesperidin and naringin in DCQD were quantified in rat serum by high performance liquid chromatography tandem mass spectrometry for studying their pharmacokinetics.


RESULTS
Early absorption of each DCQD component was tended to degrade in SAP group after treatment with DCQD by gavage. The C(max) (chrysophanol, P = 0.0059; rheochrysidin, P = 0.0288; magnolol, P = 0.0487; hesperidin, P = 0.0277; naringin, P = 0.0023) and AUC (rhein, P = 0.0186; chrysophanol, P = 0.0013; magnolol, P = 0.001; hesperidin, P = 0.0081; naringin, P = 0.0272) of DCQD component were obviously lower in SAP group than in control group. The T(1/2alpha) of chrysophanol and rheochrysidin (P = 0.0467 and 0.0005, respectively) and T(max) of chrysophanol and rheochrysidin (P = 0.0101 and 0.0037, respectively) lasted longer in SAP group than in control group.


CONCLUSIONS
SAP can significantly impact the absorption of DCQD components in rats and their pharmacokinetic parameters.
Gong
Han-Lin
HL
Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Tang
Wen-Fu
WF
Yu
Qin
Q
Xiang
Jin
J
Xia
Qing
Q
Chen
Guang-Yuan
GY
Huang
Xi
X
Liang
Mao-Zhi
MZ
D000818:Animals; D000880:Anthraquinones / Q000097:blood; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood; D001713:Biphenyl Compounds / Q000097:blood; D004791:Enzyme Inhibitors / Q000097:blood; D044950:Flavanones / Q000097:blood; D005960:Glucosides / Q000097:blood; D006569:Hesperidin / Q000097:blood; D006801:Humans; D017705:Lignans / Q000097:blood; D008297:Male; D015394:Molecular Structure; D009153:Mutagens / Q000378:metabolism; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood / Q000188:drug therapy*; D010936:Plant Extracts / Q000378:metabolism / Q000493:pharmacokinetics*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D000880:Anthraquinones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D044950:Flavanones; D005960:Glucosides; D017705:Lignans; D009153:Mutagens; D010936:Plant Extracts; C477169:dachengqi decoction; C005498:magnolol; C089997:rheochrysin; D006569:Hesperidin; C027113:chrysophanic acid; C005274:naringin; C020491:rhein