title: [Efficacy of two methods of administration of salbutamol-ipratropium bromide in asthma crises].
abstract: BACKGROUND
  Asthma acute crisis is one of the most frequent pediatric emergencies. Quick treatment with an efficient inhaled therapy may diminish considerably the number of hospitalizations and time of crises.
  
  
  OBJECTIVE
  To compare the efficacy of administration of salbutamol and ipratropium bromide by nebulization with supplementary oxygen vs salbutamol and ipratropium bromide administered in device of measured doses with space chamber for treatment of asthmatic crises in children.
  
  
  METHODS
  45 children from 1 to 12 years of age were randomly selected; they were divided into two groups and were classified according to respiratory difficulty degree. Then inhaled therapy proposed was administered three times, and oximetry and hospitalization criteria were determined.
  
  
  RESULTS
  Pediatric patients with non-severe asthma crisis had a better course with salbutamol and ipratropium bromide combination administered by device of measures doses and space chamber than with the same drugs nebulized with supplementary oxygen, and percentage of hospitalizations of children with asthma crises was reduced (p = 0.037).
  
  
  CONCLUSIONS
  Administration of salbutamol and ipratropium bromide with device of measured doses was more efficient that their administration nebulized with supplementary oxygen for treating asthmatic crises in children.
authors.affiliation: Hospital Infantil Eva Sámano, Michoacán, México.
authors.forename: H
authors.initials: H
authors.lastname: Ponce Castro
authors.forename: R
authors.initials: R
authors.lastname: Rodríguez Gaytán
authors.forename: Alain R
authors.initials: AR
authors.lastname: Rodríguez Orozco
mesh_terms: D000420:Albuterol / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D009241:Ipratropium / Q000008:administration & dosage*; D008297:Male; D009330:Nebulizers and Vaporizers; D011446:Prospective Studies; D012720:Severity of Illness Index
chemical_list: D001993:Bronchodilator Agents; D009241:Ipratropium; D000420:Albuterol