Occupational factors and risk of Parkinson's disease: A population-based case-control study.
BACKGROUND
Parkinson's disease (PD) has been associated with various workplace factors, but the evidence is inconsistent.


OBJECTIVE
To estimate the risk of PD associated with various jobs and workplace exposures.


METHODS
We conducted a population-based, case-control study of 404 incident PD cases and 526 age and sex-matched controls, collecting self-reported work histories including job titles and exposures to various industrial toxicants. Relative risks of PD from these exposures were estimated with odds ratios (OR) and 95% confidence intervals (CI) using logistic regression.


RESULTS
Risk was not significantly affected by farming work, by metal work, or by exposure to pesticides, metals, or solvents.


CONCLUSIONS
These findings do not provide support for the hypothesis that workplace factors affect the risk of PD.
Firestone
Jordan A
JA
Department of Neurology, University of Washington, Seattle, USA. jfire@u.washington.edu
Lundin
Jessica I
JI
Powers
Karen M
KM
Smith-Weller
Terri
T
Franklin
Gary M
GM
Swanson
Phillip D
PD
Longstreth
W T
WT
Checkoway
Harvey
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D015386:Hazardous Substances / Q000633:toxicity; D006801:Humans; D015994:Incidence; D007221:Industry / Q000145:classification; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D016017:Odds Ratio; D010300:Parkinson Disease / Q000453:epidemiology / Q000209:etiology*; D010575:Pesticides / Q000009:adverse effects; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014861:Washington / Q000453:epidemiology; D017132:Workplace
D015386:Hazardous Substances; D010575:Pesticides