Optimum pyrolytic conditions for furan derivative formation from polyamino sugars.
Furan derivatives were prepared by hydrolysis of glucosamine derived from polyamino sugars assisted with pyrolysis in alkaline condition. Pyrolysis was carried out with autoclaving at 15 psi/121 degrees C/1 hour. The reaction was monitored by observing spectral characteristics at lambda(max) 545 nm with p-dimethylaminobenzaldehyde. Alkaline hydrolysis favors the formation of furan derivatives in N-acetylglucosamine, glucosamine, hyaluronic acid, but not in dermatan sulfate and chondroitin sulfate. These results indicate -OH group orientation in the cis position at C(4) of the Haworth projection formula of hexosamines may be playing a role in the formation of furans. This can be a useful method for estimation of the glucosamine in glycoprotein and urine.
Badadani
Mallikarjun
M
Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore, India. badadani@gmail.com
Shetty
K Taranath
KT
D000606:Amino Sugars / Q000737:chemistry*; D005663:Furans / Q000737:chemistry*; D005944:Glucosamine / Q000737:chemistry*; D006868:Hydrolysis; D013053:Spectrophotometry
D000606:Amino Sugars; D005663:Furans; D005944:Glucosamine