Overexpression of Kif2a promotes the progression and metastasis of squamous cell carcinoma of the oral tongue.
The aim of this study was to examine the Kif2a expression and its role in tumor progression, invasion and metastasis in squamous cell carcinoma of the oral tongue (SCCOT). The study included 44 cases of primary tumor and the corresponding adjacent tissues, 20 cases of primary tumor with lymph node metastasis. Immunohistochemistry was used to observe the Kif2a expression and its correlation with clinicopathologic factors in oral tongue cancer. The immunohistochemistry showed that Kif2a expression was stronger in oral tongue cancer tissues than in paired adjacent tissues (P<0.01), and the higher expression of Kif2a was also significantly associated with lymph node metastasis (P<0.01), tumor clinical stage (P<0.01). In addition, in vitro results from transwell chamber assay showed that Tca8113 cells transfected with Kif2a-siRNA had a decreased migratory ability (P<0.01) compared to nonsense-siRNA-transfected cells. Therefore we speculate the overexpression of Kif2a might be involved in the progression, invasion and metastasis of SCCOT and Kif2a should be as a predictor for prognosis.
Wang
Cheng-Qin
CQ
Department of Pathology, The School of Stomatology, Shandong University, Jinan, Shandong 250012, People's Republic of China.
Qu
Xun
X
Zhang
Xiao-Ying
XY
Zhou
Cheng-Jun
CJ
Liu
Gui-Xiang
GX
Dong
Zuo-Qing
ZQ
Wei
Feng-Cai
FC
Sun
Shan-Zhen
SZ
D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016547:Kinesins / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014062:Tongue Neoplasms / Q000378:metabolism* / Q000473:pathology
D014408:Biomarkers, Tumor; C509805:KIF2A protein, human; D016547:Kinesins