Plasma CA-125 level is related to both sides of the heart: a retrospective analysis.
OBJECTIVE
CA-125 is an old marker, recently shown to be associated with systolic heart failure. We aimed to search for factors influencing its plasma level.


METHODS
430 patients with one available CA-125 level were investigated retrospectively. 150 patients who had echocardiographic records were enrolled into final analysis. Patients were followed up, hospitalization and mortality were noted.


RESULTS
CA-125 levels were negatively correlated with ejection fraction (r=-0.269, p=0.001) and positively correlated with systolic pulmonary artery pressure (r=0.370, p<0.001). In the whole group, patients with right ventricular dilatation (n=68) had significantly higher CA-125 levels compared to those without right ventricular dilatation (n=82) (125.8±118.4 U/ml vs.16.9±16.5 U/ml, p<0.001). Presence of depressed ejection fraction (B=1.837, p=0.004), presence of right ventricular dilatation (B=4.294, p=0.002) and presence of pericardial effusion (B=1.913, p=0.018) were independent predictors of high CA-125 levels. After follow up, patients with high CA-125 level encountered more frequent hospitalization and mortality, and atrial fibrillation was more frequent among those with high CA-125.


CONCLUSIONS
Our data suggests that plasma levels of CA-125 seem to be determined by left ventricular ejection fraction, right ventricular dilatation and presence of pericardial effusion in a group of all comers. It seems prudent to consider these factors before integrating CA-125 into clinical practice.
Yilmaz
Mehmet Birhan
MB
Cumhuriyet University School of Medicine, Department of Cardiology, Sivas, Turkey. cardioceptor@gmail.com
Zorlu
Ali
A
Tandogan
Izzet
I
D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000097:blood / Q000401:mortality; D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D004452:Echocardiography; D005260:Female; D054143:Heart Failure, Systolic / Q000097:blood* / Q000000981:diagnostic imaging / Q000401:mortality*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D010490:Pericardial Effusion / Q000097:blood / Q000000981:diagnostic imaging / Q000401:mortality; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013318:Stroke Volume; D018497:Ventricular Dysfunction, Right / Q000097:blood* / Q000000981:diagnostic imaging / Q000401:mortality*
D015415:Biomarkers; D018394:CA-125 Antigen