title: Expression and mutation analysis of her2 in head and neck squamous cell carcinoma.
abstract: We analyzed mutation and expression status of human epidermal growth factor receptor 2 (Her2) in head and neck squamous cell carcinoma (HNSCC) using single strand conformation polymorphism (SSCP) mutation analysis and immunohistochemistry (IHC). Mutations were absent in all 85 cases. Out of 57 cases available for IHC, Her2 protein expression was negative (0) in 40 tumors (70%). Seventeen tumors (29.8%) expressed Her2, among these 13 tumors (22.8%) showed a weak (+1) expression and 4 (7%) showed a moderate expression (+2), none showed a strong (+3) expression. There was not a significant association between expression and any of the patients' clinical variables or prognosis. Our results suggest that Her2 may not be useful as a molecular target in HNSCC.
authors.affiliation: Department of Oral Pathology and Medicine, Okayama University, Japan.
authors.forename: Mahmoud A L Sheikh
authors.initials: MA
authors.lastname: Ali
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gunduz
authors.forename: Esra
authors.initials: E
authors.lastname: Gunduz
authors.forename: Ryo
authors.initials: R
authors.lastname: Tamamura
authors.forename: Levent Bekir
authors.initials: LB
authors.lastname: Beder
authors.forename: Naoki
authors.initials: N
authors.lastname: Katase
authors.forename: Omer Faruk
authors.initials: OF
authors.lastname: Hatipoglu
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Fukushima
authors.forename: Noboru
authors.initials: N
authors.lastname: Yamanaka
authors.forename: Kenji
authors.initials: K
authors.lastname: Shimizu
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nagatsuka
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality; D004252:DNA Mutational Analysis; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation
chemical_list: D066246:ErbB Receptors