title: Studies on chemical constituents of the leaves of Smallantus sonchifolius (yacon): structures of two new diterpenes.
abstract: The extract from the leaves of Smallantus sonchifolius (yacon) was found to show potent anti-diabetic activity. Two new diterpenes, named ent-kaurane-3beta,16beta,17, 19-tetrol (1) and ent-kaurane-16beta,17,18,19-tetrol (2), were isolated from the extract, together with six known compounds. The structures of the new compounds were determined on the basis of chemical and physicochemical evidence.
authors.affiliation: College of Pharmacy, Liaoning University of Traditional Chinese Medicine, 77 Life One Road, Dalian 116600, China.
authors.forename: De-Qiang
authors.initials: DQ
authors.lastname: Dou
authors.forename: Fang
authors.initials: F
authors.lastname: Tian
authors.forename: Ying-Kun
authors.initials: YK
authors.lastname: Qiu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xiang
authors.forename: Bi Xia
authors.initials: BX
authors.lastname: Xu
authors.forename: Ting Guo
authors.initials: TG
authors.lastname: Kang
authors.forename: Feng
authors.initials: F
authors.lastname: Dong
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D002236:Carbohydrate Conformation; D002851:Chromatography, High Pressure Liquid; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D004224:Diterpenes / Q000737:chemistry*; D045786:Diterpenes, Kaurane / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008958:Models, Molecular; D018515:Plant Leaves / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004224:Diterpenes; D045786:Diterpenes, Kaurane; C547242:ent-kaurane-16beta,17,18,19-tetrol; C547241:ent-kaurane-3beta,16beta,17,19-tetrol