title: Correlation of autoantibodies and CD5+ B cells in ocular adnexal marginal zone B cell lymphomas.
abstract: OBJECTIVE
  To determine the clinicopathological properties of ocular adnexal marginal zone B cell lymphomas (MZBLs) with CD5+ B cells.
  
  
  METHODS
  This study determined the clinicopathological properties of MZBL samples from 97 patients with ocular adnexal MZBLs and searched for hallmarks of systemic autoimmunity in these patients.
  
  
  RESULTS
  Two elderly female patients were found to have ocular adnexal MZBLs with CD5+ B cells; flow cytometry analysis suggested that one of these MZBLs had CD5+ B cell clonal proliferation. The levels of anti-single stranded (SS)-DNA and anti-SS-A/Ro antibodies in these two patients were significantly higher than those in controls that were matched for age, gender and disease (2/2 versus 0/14; p = 0.008) and controls without MZBL (2/2 versus 0/30; p = 0.002). The genes from the immunoglobulin heavy-chain variable region for one of the patients showed a V3-21 segment. In addition, another patient with ocular adnexal reactive lymphoid hyperplasia with CD5+ B cells also had anti-SS-DNA antibodies.
  
  
  CONCLUSIONS
  Patients with ocular adnexal MZBLs with CD5+ B cells may have a background of systemic conditions with CD5+ B-cell-related autoantibodies.
authors.affiliation: Department of Ophthalmology, National Hospital Organization, Nagoya Medical Center, Japan. ganiky@nnh.hosp.go.jp
authors.forename: T
authors.initials: T
authors.lastname: Kubota
authors.forename: S
authors.initials: S
authors.lastname: Moritani
authors.forename: T
authors.initials: T
authors.lastname: Yoshino
authors.forename: H
authors.initials: H
authors.lastname: Nagai
authors.forename: H
authors.initials: H
authors.lastname: Terasaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D018956:CD5 Antigens / Q000097:blood*; D016022:Case-Control Studies; D049109:Cell Proliferation; D004277:DNA, Single-Stranded / Q000276:immunology; D005260:Female; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000276:immunology* / Q000473:pathology
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D018956:CD5 Antigens; D004277:DNA, Single-Stranded