[Diagnosis of H. pylori infection in children].
There are two types of diagnostic tests used to detect H. pylori infection: non-invasive and invasive in children. Non-invasive tests include the urea breath test, stool antigen tests, and blood or urine serologic assays which detect the presence or absence of infection. The urea breath test and stool antigen test have adequate sensitivity and specificity in children and recommended to detect active H. pylori infection before and after eradication therapy. Invasive tests include the performance of upper gastrointestinal endoscopy with gastric biopsy. The histopathology can determine both presence or absence of infection and the extent and severity of mucosal injury (i.e., disease). Culture of gastric tissue has 100% specificity and the antimicrobial susceptibility test is available. Non-invasive tests are developed for use in children, the use of upper gastrointestinal endoscopy with gastric biopsy remains the diagnostic strategy of choice in symptomatic children.
Nakayama
Yoshiko
Y
Department of Pediatrics, Shinshu University School of Medicine.
Hidaka
Nao
N
Kato
Sawako
S
Horiuch
Akira
A
Koike
Kenichi
K
D002648:Child; D016099:Endoscopy, Gastrointestinal; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori; D006801:Humans; D012680:Sensitivity and Specificity