title: Fasting serum level of fatty-acid-binding protein 4 positively correlates with metabolic syndrome in patients with coronary artery disease.
abstract: BACKGROUND
  The serum level of fatty-acid-binding protein 4 (FABP4) increases in patients with metabolic syndrome (MetS), so the relationship between FABP4 and MetS among patients with coronary artery disease (CAD) was investigated in the present study.
  
  
  RESULTS
  Fasting blood samples were obtained from 98 CAD patients. MetS and its components were defined using the diagnostic criteria of the International Diabetes Federation; 50 CAD patients (51.0%) had MetS. The fasting level of FABP4 positively correlated with MetS (P=0.037) and serum levels of FABP4 correlated with a number of MetS criteria (P=0.035). Univariate linear regression analysis showed that body fat mass (R=0.234; P=0.020) and the levels of triglycerides (R=0.348; P<0.001), and low-density lipoprotein-cholesterol (R=0.217; P=0.032) positively correlated with the serum level of FABP4, whereas the level of high-density lipoprotein-cholesterol (R=-0.243; P=0.016) negatively correlated with it. Multivariate forward stepwise linear regression analysis of the significant variables showed that the level of triglycerides (beta=0.348, R(2)=0.121, P<0.001) was the independent predictor of fasting serum level of FABP4.
  
  
  CONCLUSIONS
  Among CAD patients in the present study, the fasting level of FABP4 positively correlated with MetS and serum levels of FABP4 correlated with a number of MetS criteria.
authors.affiliation: School of Medicine, Tzu Chi University, Hualien, Taiwan.
authors.forename: Bang-Gee
authors.initials: BG
authors.lastname: Hsu
authors.forename: Yu-Chih
authors.initials: YC
authors.lastname: Chen
authors.forename: Ru-Ping
authors.initials: RP
authors.lastname: Lee
authors.forename: Chia-Chi
authors.initials: CC
authors.lastname: Lee
authors.forename: Chung-Jen
authors.initials: CJ
authors.lastname: Lee
authors.forename: Ji-Hung
authors.initials: JH
authors.lastname: Wang
mesh_terms: D050154:Adiposity; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D023921:Coronary Stenosis / Q000097:blood*; D003430:Cross-Sectional Studies; D005215:Fasting / Q000097:blood; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D014280:Triglycerides