[Effects of clobenpropit and histidine on reinstatement of morphine-induced conditioned place preference].
To investigate the effects of clobenpropit and histidine on reinstatement of morphine-induced conditioned place preference (CPP) in rats.



The persistence, extinction and reinstatement of morphine-induced CPP were established.In clobenpropit group three different doses of clobenpropit (2, 5 and 10 microg/rat, i.c.v.) were administered 15 min after morphine (1 mg/kg, i.p.) was injected. In histidine group histidine (100, 200, 500 mg/kg) was given 1 h prior to morphine treatment (1 mg/kg i.p).



The CPP was reinstated by priming injection of 1 mg/kg morphine. Clobenpropit (5, 10 microg/rat) significantly inhabited the reinstatement by a priming dose of morphine-induced CPP compared with the morphine control group; histidine (100, 200, 500 mg/kg) significantly inhibited the reinstatement in a dose-dependent manner.



Clobenpropit and histidine inhibit the revival of morphine-induced CPP in a dose dependent manner, indicating that endogenous histamine may inhibit relapse of morphine to some extent.
Wang
Hui-Juan
HJ
Department of Pharmacy, The Affiliated Children's Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
Lu
Min
M
Gong
Ying-Xia
YX
Chen
Zhong
Z
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D006639:Histidine / Q000378:metabolism*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D009021:Morphine Dependence / Q000503:physiopathology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology; D013890:Thiourea / Q000031:analogs & derivatives* / Q000494:pharmacology
D007093:Imidazoles; D011956:Receptors, Cell Surface; D006639:Histidine; D013890:Thiourea; C086108:clobenpropit