title: Colonoscopy screening for individuals aged 40-49 years with a family history of stomach cancer in Korea.
abstract: BACKGROUND
  For asymptomatic individuals aged 40-49 years, screening for colorectal cancer is recommended only if individuals are at an increased risk. A family history of colon cancer (FHCRC) is considered to increase risk, however, whether family history of stomach cancer (FHSC) increases the risk of adenoma is not well known. We aimed to see whether FHSC increases the risk in asymptomatic individuals aged 40-49 years in Korea.
  
  
  METHODS
  Among asymptomatic individual aged 40-49 years who underwent colonoscopy screening, risk of adenoma was assessed according to FHCRC or FHSC.
  
  
  RESULTS
  Of 3,160 individuals, male comprised 1,602 individuals (50.7%). FHCRC and FHSC was noticed in 163 (5.2%) and 227 (7.0%) individuals, respectively. Prevalence of adenoma was 31.9 %, 28.8%, and 22.3% for individuals with FHCRC, individuals with FHSC, and individuals without family history of cancer, respectively. FHSC was an independent risk factor for adenoma (odds ratio, 1.38; 95% confidence interval, 1.02-1.87, P = 0.039) in asymptomatic individuals aged 40-49 years. Compared with individuals with FHCRC, individuals with FHSC showed no difference in risk for adenoma (P = 0.347).
  
  
  CONCLUSIONS
  As with individuals with FHCRC, individuals with FHSC might need to be considered as an individual with increased risk for adenoma. Therefore, earlier screening might be needed for asymptomatic individuals aged 40-49 years with FHSC in Korea.
authors.affiliation: Department of Gastroenterology, Daehang Hospital, Seoul, South Korea. yschoi71@dreamwiz.com
authors.forename: Yong Sung
authors.initials: YS
authors.lastname: Choi
authors.forename: Jung Pil
authors.initials: JP
authors.lastname: Suh
authors.forename: Doo Seok
authors.initials: DS
authors.lastname: Lee
authors.forename: Eui Gon
authors.initials: EG
authors.lastname: Youk
authors.forename: In Taek
authors.initials: IT
authors.lastname: Lee
authors.forename: Suk Hee
authors.initials: SH
authors.lastname: Lee
authors.forename: Do Sun
authors.initials: DS
authors.lastname: Kim
authors.forename: Doo Han
authors.initials: DH
authors.lastname: Lee
mesh_terms: D000236:Adenoma / Q000453:epidemiology*; D000328:Adult; D003110:Colonic Neoplasms / Q000453:epidemiology*; D003113:Colonoscopy / Q000706:statistics & numerical data*; D005192:Family Health; D005260:Female; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008403:Mass Screening / Q000379:methods* / Q000706:statistics & numerical data; D008875:Middle Aged; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology*