[Study on the association of the CRP gene +1444C/T polymorphism with symptomatic carotid artery stenosis].
OBJECTIVE
To investigate the potential association of the C-reactive protein (CRP) gene +1444C/T polymorphism with symptomatic carotid artery stenosis.


METHODS
Polymerase chain reaction-restriction fragment length polymorphism was used for the detection of CRP +1444C/T genotypes in 192 patients with symptomatic carotid artery stenosis and 197 healthy controls. Serum high sensitivity-CRP (hs-CRP) levels were measured by routine method.


RESULTS
No TT genotype was detected in this study. Patients with >70% stenosis had higher CC genotype compared with those with <70% stenosis after adjusting for major cerebrovascular risk factors (OR: 2.958; 95% CI: 1.198 - 7.305; P=0.019). CRP levels were significantly higher in patients than in controls. Subgroup analysis according to clinical characteristics (single or double stenosis; >70% or <70% stenosis) did not show difference in CRP levels. There was no significant difference in the prevalence of CT genotype between patients and controls, or between single and double stenosis (P>0.05).


CONCLUSIONS
The CRP +1444 CC genotype is a risk factor for >70% carotid artery stenosis. The serum CRP level is associated with the presence of carotid stenosis. However, it is not associated with the number and severity of stenosis.
Liu
Zhi-zhong
ZZ
Center for Laboratory Diagnosis, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050 P.R. China.
Ding
Xiu-rong
XR
Zheng
Hua-guang
HG
Zhang
Guo
G
Wang
Rui-min
RM
Kang
Xi-xiong
XX
D000368:Aged; D002097:C-Reactive Protein / Q000235:genetics* / Q000378:metabolism; D016893:Carotid Stenosis / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D002097:C-Reactive Protein