title: [Hepatotoxicity of antineoplastic agents].
abstract: The influence of various antineoplastic preparations (farmorubicin, paclitaxel, etoposide, platidiam) on morphological and functional status of the liver in experimental animals was studied. It is shown, that all these antineoplastic drugs possess strong hepatotoxic activity and thereby cause toxic hepatitis and increase activity of hepatic enzymes. Biochemical parameters were normalized within 30 days after treatment whereas morphological changes persisted somewhat longer.
authors.forename: G V
authors.initials: GV
authors.lastname: Karpova
authors.forename: T I
authors.initials: TI
authors.lastname: Fomina
authors.forename: T V
authors.initials: TV
authors.lastname: Vetoshkina
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Dubskaia
authors.forename: L A
authors.initials: LA
authors.lastname: Ermolaeva
authors.forename: A A
authors.initials: AA
authors.lastname: Churin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051381:Rats; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents