[Role of host genetic factors in gastric carcinogenesis].
Helicobacter pylori infection is the most common chronic bacterial infection worldwide and the most important acquired risk factor for gastric cancer. Bacterial, environmental and host genetic factors combine to define the degree of gastric damage. The most relevant and consistent genetic factors are in the interleukin-1B and tumor necrosis factor-A gene clusters. These cytokines play a key role in the gastric carcinogenesis and their roles have been confirmed in mouse models. More genetic factors have also been uncovered recently and certain cytokine and innate immune response gene polymorphisms appear to influence risk of gastric cancer and its precursor conditions. In the near future, we will be able to define a more comprehensive genetic profile that would identify high risk groups of developing gastric cancer.
Kudo
Takahiko
T
Division of Endoscopy, Toyama University Hospital.
Kane
Tatsuhiko
T
Fujinami
Haruka
H
Nishikawa
Jun
J
Miyazaki
Takako
T
Sugiyama
Toshiro
T
D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics; D005810:Multigene Family; D013274:Stomach Neoplasms / Q000209:etiology* / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha