Gomphostenins: two new antimalarial compounds from the leaves of Gomphostemma niveum.
Phytochemical investigation of CHCl(3) extract of the Gomphostemma niveum leaves led to the isolation of two new diterpene, compound 1 and 2. Their structures were elucidated by spectroscopic procedures and single crystal XRD. Compound 1 named as Gomphostenin 1 and structure was established as 8-ethyl (5H-furan-2-one, 14-hydroxy, 2-oxo 3, 20 Z(17) diene clerodane, while compound 2 named as Gomphostenin-A; was found to be the acetyl derivative of compound 1 and revealed as 8-ethyl (5H-furan-2-one, 14-acetoxy, 2-oxo 3, 20 Z(17) diene clerodane. In vitro antimalarial activity against Plasmodium falciparum showed that compound 2 was more active than compound 1 and CHCl(3) extract as well; with IC(50) value of 3.4 microg/mL.
Sathe
Manisha
M
Discovery Center, Process Technology Development Division, Defence R&D Establishment, Jhansi Road, Gwalior 474 002, MP, India.
Kaushik
M P
MP
D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002478:Cells, Cultured; D018360:Crystallography, X-Ray; D006801:Humans; D019686:Lamiaceae; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves; D010963:Plasmodium falciparum / Q000187:drug effects / Q000502:physiology
D000962:Antimalarials; D010936:Plant Extracts