title: An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging.
abstract: An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[(18)F]fluororibose, a novel [(18)F]-fluorinated sugar suitable for positron emission tomography (PET) applications.
authors.affiliation: University of St Andrews, School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife, UKKY16 9ST. do1@st-andrews.ac.uk.
authors.forename: Mayca
authors.initials: M
authors.lastname: Onega
authors.forename: Juozas
authors.initials: J
authors.lastname: Domarkas
authors.forename: Hai
authors.initials: H
authors.lastname: Deng
authors.forename: Lutz F
authors.initials: LF
authors.lastname: Schweiger
authors.forename: Timothy A D
authors.initials: TA
authors.lastname: Smith
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Welch
authors.forename: Christophe
authors.initials: C
authors.lastname: Plisson
authors.forename: Antony D
authors.initials: AD
authors.lastname: Gee
authors.forename: David
authors.initials: D
authors.lastname: O'Hagan
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D055162:Biocatalysis; D045744:Cell Line, Tumor; D005462:Fluorine Radioisotopes / Q000737:chemistry; D054879:Halogenation; D006801:Humans; D009699:N-Glycosyl Hydrolases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D049268:Positron-Emission Tomography; D012266:Ribose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: C547238:5-deoxy-5-(18F)fluororibose; D001426:Bacterial Proteins; D005462:Fluorine Radioisotopes; D012266:Ribose; D010088:Oxidoreductases; C495766:fluorinase; D009699:N-Glycosyl Hydrolases