title: Endoscopic approach for excision of juvenile nasopharyngeal angiofibroma: complications and outcomes.
abstract: The purposes of this study are to report the efficacy of the endoscopic approach for juvenile nasopharyngeal angiofibroma (JNA) and to compare its related intra- and postoperative complications with findings from traditional approaches in the literatures. This study is a retrospective report of 47 cases of JNA that were treated with nasal endoscopic surgery between 1998 and 2005. According to the staging system by Radkowski et al (Arch Otolaryngol Head Neck Surg. 1996;122:122-129), the staging of the included patients were the following: 21 in stages IA to IIB, 22 in IIC, 3 in IIIA, and 1 in IIIB. Five patients were embolized before surgery. The mean blood hemorrhage in embolized patients was 770 mL, whereas in nonembolized patients, it was 1403.6 mL. In the follow-up period (mean, 2.5 years), the recurrence was found in 9 patients (19.1%), and mean time of recurrence was 17 months after surgery. The rupture of cavernous sinus occurred in 2 cases with no mortality. The mean hospital stay was 3.1 days in all cases and 1.8 days in embolized patients. The findings of this study demonstrate that endoscopic resection of JNA is a safe and effective technique because of decrease in blood loss, hospitalization, and recurrence rate, especially in tumors that are not extended through intracranial space. It is therefore strongly recommended that this modality is implemented as the first surgical step for tumors with stages I to IIIA of the Radkowski's staging system.
authors.affiliation: Otolaryngology, Head and Neck Surgery, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mojtaba Mohammadi
authors.initials: MM
authors.lastname: Ardehali
authors.forename: Seyed-Hadyi
authors.initials: SH
authors.lastname: Samimi Ardestani
authors.forename: Nasrin
authors.initials: N
authors.lastname: Yazdani
authors.forename: Hassan
authors.initials: H
authors.lastname: Goodarzi
authors.forename: Shahin
authors.initials: S
authors.lastname: Bastaninejad
mesh_terms: D000293:Adolescent; D000328:Adult; D018322:Angiofibroma / Q000473:pathology / Q000628:therapy*; D002648:Child; D004621:Embolization, Therapeutic; D004724:Endoscopy / Q000009:adverse effects; D006801:Humans; D007902:Length of Stay; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging; D019106:Postoperative Hemorrhage; D011300:Preoperative Care; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult