title: The effect of prophylactic dose of a low molecular weight heparin on skin wound healing of rats.
abstract: OBJECTIVE
  To investigate the effect of prophylactic dose of a low molecular weight heparin, enoxaparin, on skin wound healing of rats.
  
  
  METHODS
  Forty rats were used for the study. Rats were randomly assigned to two equal groups. Experimental group received prophylactic dose of enoxaparin. Physiologic saline was administered to the control group. Parameters of wound healing of experimental and control groups were compared. For comparison of the groups in terms of fibrosis, vascularization, inflammation, epithelization, and tensile strength test (Newton). Mann-Whitney-U test was used because variables were categorical data (fibrosis, vascularization, inflammation and epithelization). Differences between groups were analyzed with independent samples t-test (tensile strength). Significance was set at p<0.05.
  
  
  RESULTS
  Skin wound of the experimental group presented tensile strength significantly decreased (p<0.001), histopathologic examination revealed a significant (p<0.001) delayed epithelization and decreased in fibrosis, vascularization, inflammation (p<0.001) in the experimental group.
  
  
  CONCLUSIONS
  Enoxaparin delay wound healing by decreased inflammatory cells, fibroblast contents and their products (growth factors), and by promoted hemorrhage.
authors.affiliation: Experimental Animal Laboratory, Faculty of Medicine, University of Ankara, Yenimahalle, Ankara, Turkey. fuadoken@yahoo.com
authors.forename: Ozdamar Fuad
authors.initials: OF
authors.lastname: Oken
authors.forename: Ahmet Ozgur
authors.initials: AO
authors.lastname: Yildirim
authors.forename: Murat
authors.initials: M
authors.lastname: Gulcek
authors.forename: Vuslat Sema
authors.initials: VS
authors.lastname: Unal
authors.forename: Akin
authors.initials: A
authors.lastname: Karakuyu
authors.forename: Korhan
authors.initials: K
authors.lastname: Ozlu
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ucaner
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D017984:Enoxaparin / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects; D023421:Models, Animal; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D018709:Statistics, Nonparametric; D013718:Tensile Strength / Q000187:drug effects; D020246:Venous Thrombosis / Q000517:prevention & control*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin