title: Purpura fulminans in a newborn infant with galactosemia.
abstract: An 11-day-old neonate presented with purpura fulminans and was subsequently diagnosed with galactosemia. Neonatal purpura fulminans occurs predominantly in patients suffering from inherited protein C deficiency or disseminated intravascular coagulation associated with septicemia. Hemostatic changes in patients with liver disease may result in bleeding or, rarely, thrombosis. We suppose that in the present patient, deficiency of protein C, secondary to liver disease, was responsible for the development of purpura fulminans. Treatment consisted of blood and blood products and galactose-free formula. The patient recovered with residual mild psychomotor retardation and the lesions with minimal scarring. In conclusion, galactosemia also should be kept in mind as an uncommon cause of purpura fulminans in newborn infants.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Dr. Sami Ulus Maternity and Children's Hospital, Babur Street, No: 44, Altindag, 06080, Ankara, Turkey.
authors.forename: Aysegul
authors.initials: A
authors.lastname: Zenciroglu
authors.forename: Mehmet Sah
authors.initials: MS
authors.lastname: Ipek
authors.forename: Mustafa
authors.initials: M
authors.lastname: Aydin
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Kara
authors.forename: Nurullah
authors.initials: N
authors.lastname: Okumus
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kilic
mesh_terms: D005260:Female; D005693:Galactosemias / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D009154:Mutation; D011486:Protein C / Q000378:metabolism; D055665:Purpura Fulminans / Q000209:etiology*
chemical_list: D011486:Protein C; D042965:Methylenetetrahydrofolate Reductase (NADPH2)