title: [Infective endocarditis in a dermatology unit].
abstract: BACKGROUND
  Although often clinically suspected, infectious endocarditis (IE) is frequently difficult to diagnose with certainty. Although the dermatological signs of endocarditis can vary, they must be routinely sought where there is a suspicion of IE. The aim of this study was to reveal the diversity of clinical manifestations of IE in a dermatology unit.
  
  
  METHODS
  This retrospective study was conducted between May 2006 and May 2007 and included all patients hospitalized in the dermatology unit in whom an IE was diagnosed according to the modified Duke criteria.
  
  
  RESULTS
  Seven patients were included with a median age of 61 years. The reasons for hospital admission were: chronic ulcers (n=1), Sezary's syndrome (n=1), atopic dermatitis (n=1), epidermolysis bullosa acquisita (n=1) and purpura (n=1). Specific dermatological manifestations of IE included necrotic lesions on the lower limbs (n=2), purpura (n=5) and splinter haemorrhages (n=1). Blood cultures were positive in 3 cases (MSSA=2, MRSA=1). One patient had serological evidence of Coxiella burnetti IE. Cutaneous sources of IE were found in 6 cases, including acute dermohypodermitis or chronic dermatosis (3), peripheral venous catheter (n=2) and haemodialysis (n=1). Transthoracic echocardiography was negative in 6 patients, whereas transoesophageal echocardiography performed in 6 patients confirmed the diagnosis in 5 cases. The mean time to diagnosis was 21 days. Among these patients, 5 died after a mean period of 78 days.
  
  
  CONCLUSIONS
  Diagnosing IE remains a clinical challenge and must be routinely considered in the presence of unusual dermatological findings such as purpura or distal necrosis, but also in patients with partially or poorly controlled chronic dermatosis, which comprise an underestimated potential source of IE. Physicians treating such patients must consider the risk of IE, especially in the event of chronic dermatosis or of an invasive cutaneous procedure involving affected skin.
authors.affiliation: Service de dermatologie, hôpital Henri-Mondor, AP-HP, université Paris-XII, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France.
authors.forename: M-P
authors.initials: MP
authors.lastname: Konstantinou
authors.forename: L
authors.initials: L
authors.lastname: Valeyrie-Allanore
authors.forename: P
authors.initials: P
authors.lastname: Lesprit
authors.forename: S
authors.initials: S
authors.lastname: Terrazzoni
authors.forename: N
authors.initials: N
authors.lastname: Ortonne
authors.forename: J-C
authors.initials: JC
authors.lastname: Roujeau
authors.forename: M
authors.initials: M
authors.lastname: Bagot
mesh_terms: D003876:Dermatitis, Atopic / Q000150:complications; D004696:Endocarditis / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D016107:Epidermolysis Bullosa Acquisita / Q000150:complications; D006757:Hospital Units / Q000706:statistics & numerical data; D006801:Humans; D008875:Middle Aged; D009336:Necrosis; D012189:Retrospective Studies; D012751:Sezary Syndrome / Q000150:complications; D015996:Survival Rate; D016896:Treatment Outcome; D014456:Ulcer / Q000150:complications