During transitions proteins make fleeting bonds.
How do proteins efficiently and precisely shift from one conformation to another? Gardino et al. (2009) show that transient hydrogen bonds are critical to the conformational transition of the nitrogen regulatory protein NtrC between its native state and its active state.
Boehr
David D
DD
Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.
D051922:PII Nitrogen Regulatory Proteins / Q000378:metabolism; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism
D051922:PII Nitrogen Regulatory Proteins; D011506:Proteins