title: Asymmetric synthesis of alpha-tocopherol.
abstract: Alpha-tocopherol was synthesized from a chiral intermediate alpha-hydroxy ester by means of two ring-closing methods to yield the chromanol in 94% diastereomeric excess.
authors.affiliation: Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland.
authors.forename: Urs
authors.initials: U
authors.lastname: Hengartner
authors.forename: Antoinette
authors.initials: A
authors.lastname: Chougnet
authors.forename: Kegang
authors.initials: K
authors.lastname: Liu
authors.forename: Wolf-D
authors.initials: WD
authors.lastname: Woggon
mesh_terms: D002839:Chromans / Q000737:chemistry; D003500:Cyclization; D013237:Stereoisomerism; D024502:alpha-Tocopherol / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D002839:Chromans; C029141:2,2,5,7,8-pentamethyl-1-hydroxychroman; D024502:alpha-Tocopherol