Light-responsive biomaterials: development and applications.
Novel biomaterials are beneficial to the growing fields of drug delivery, cell biology, micro-devices, and tissue engineering. With recent advances in chemistry and materials science, light is becoming an attractive option as a method to control biomaterial behavior and properties. In this Feature Article, we explore some of the early and recent advances in the design of light-responsive biomaterials. Particular attention is paid to macromolecular assemblies for drug delivery, multi-component surface patterning for advanced cell assays, and polymer networks that undergo chemical or shape changes upon light exposure. We conclude with some remarks about future directions of the field.
Katz
Joshua S
JS
University of Pennsylvania, Department of Bioengineering, 210 South 33rd Street, 240 Skirkanich Hall, Philadelphia, PA 19104, USA.
Burdick
Jason A
JA
D001672:Biocompatible Materials / Q000737:chemistry* / Q000528:radiation effects*; D018929:Cell Culture Techniques / Q000379:methods; D016503:Drug Delivery Systems; D020100:Hydrogels / Q000737:chemistry / Q000528:radiation effects; D007259:Infrared Rays; D008027:Light; D008055:Lipids / Q000737:chemistry / Q000528:radiation effects; D008081:Liposomes / Q000737:chemistry / Q000528:radiation effects; D046911:Macromolecular Substances / Q000737:chemistry / Q000528:radiation effects; D008823:Micelles; D008968:Molecular Conformation / Q000528:radiation effects; D053758:Nanoparticles / Q000737:chemistry / Q000528:radiation effects; D055668:Photochemical Processes; D011108:Polymers / Q000737:chemistry / Q000528:radiation effects; D013499:Surface Properties / Q000528:radiation effects; D014466:Ultraviolet Rays
D001672:Biocompatible Materials; D020100:Hydrogels; D008055:Lipids; D008081:Liposomes; D046911:Macromolecular Substances; D008823:Micelles; D011108:Polymers