The hypolipidemic effect of Hibiscus sabdariffa polyphenols via inhibiting lipogenesis and promoting hepatic lipid clearance.
Hibiscus sabdariffa extract (HSE) was shown to lower the plasma lipid level and reduce the liver damage. In the present study, we investigated if Hibiscus sabdariffa polyphenols (HPE) exerted a hypolipidemic effect and its putative mechanism on liver. HPE exhibited more potency to decrease plasma cholesterol and LDL cholesterol than the crude extract HSE, and increased HDL cholesterol dose-dependently. It decreased the lipid content of hepatocyte through the activation of AMPK and reduction of SREBP-1, thus inhibiting the expression of fatty acid synthase and HMG-CoA reductase. LDLR and LDL binding of HepG2 cells were enhanced when treated with HPE. In conclusion, HPE is worthy of being further investigated and could be developed as an adjunctive for hepatic lipid control and hypolipidemic therapy.
Yang
Mon-Yuan
MY
Institute of Biochemistry and Biotechnology, Chung-Shan Medical University, Taichung 402, Taiwan.
Peng
Chiung-Huei
CH
Chan
Kuei-Chuan
KC
Yang
Yi-Sun
YS
Huang
Chien-Ning
CN
Wang
Chau-Jong
CJ
D000818:Animals; D006224:Cricetinae; D015536:Down-Regulation; D064429:Fatty Acid Synthases / Q000235:genetics / Q000378:metabolism; D005419:Flavonoids / Q000008:administration & dosage*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D056945:Hep G2 Cells; D031584:Hibiscus / Q000737:chemistry*; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000008:administration & dosage*; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000096:biosynthesis; D050155:Lipogenesis / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D010636:Phenols / Q000008:administration & dosage*; D010936:Plant Extracts / Q000008:administration & dosage*; D059808:Polyphenols
D005419:Flavonoids; D000960:Hypolipidemic Agents; D008055:Lipids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D006903:Hydroxymethylglutaryl CoA Reductases; D064429:Fatty Acid Synthases