title: Proteolytic regulatory mechanism of chemerin bioactivity.
abstract: Chemerin is a novel chemoattractant recognized by chemokine-like receptor 1 (CMKLR1), a serpentine receptor expressed primarily by plasmacytoid dendritic cells, natural killer cells, and macrophages. Human prochemerin circulates in plasma as an inactive precursor. Its chemotactic activity is expressed upon cleavage of the C-terminal amino acid residues by proteases of the coagulation, fibrinolytic, and inflammatory system. The C-terminal cleavage site of prochemerin is highly conservative, indicating that the proteolytic regulation of chemerin bioactivity is a common mechanism undertaken by different species. In this review, we summarized chemerin-proteases interactions, chemerin receptors, and their importance in normal and pathologic conditions.
authors.affiliation: Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA. duxiaoyan@hotmail.com
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Du
authors.forename: Lawrence L K
authors.initials: LL
authors.lastname: Leung
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001685:Biological Factors / Q000235:genetics / Q000502:physiology*; D018925:Chemokines / Q000737:chemistry / Q000378:metabolism*; D020536:Enzyme Activators / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008969:Molecular Sequence Data; D010447:Peptide Hydrolases / Q000276:immunology / Q000378:metabolism*; D019707:Receptors, Chemokine / Q000276:immunology / Q000378:metabolism*
chemical_list: D001685:Biological Factors; D018925:Chemokines; D020536:Enzyme Activators; D019707:Receptors, Chemokine; D010447:Peptide Hydrolases