title: [Minimize kidney failure in transplantation patients with proliferation signal inhibitors].
abstract: Chronic renal dysfunction is a multifactorial and frequent event after organ transplantation. The measurement or the estimation of glomerular filtration rate is essential to detect early progressive renal dysfunction. Proliferation signal inhibitors are nonnephrotoxic immunosuppressive drugs which may be useful to minimize calcineurin inhibitors-related side effects through a conversion strategy. Most studies in the setting of kidney transplantation showed improvement in glomerular filtration rate as high than conversion was early. Proliferation signal inhibitors may be included quickly in new immunosuppressive regimen for liver transplanted patients with chronic renal dysfunction.
authors.affiliation: Pôle de Néphrologie, Hôpital Albert Calmette, CHRU de Lille, Bd du Pr Leclercq, 59037 Lille cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Glowacki
authors.forename: S
authors.initials: S
authors.lastname: Dharancy
authors.forename: C
authors.initials: C
authors.lastname: Noël
authors.forename: M
authors.initials: M
authors.lastname: Hazzan
mesh_terms: D065095:Calcineurin Inhibitors; D016572:Cyclosporine / Q000008:administration & dosage; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors*; D007674:Kidney Diseases / Q000139:chemically induced; D016030:Kidney Transplantation / Q000379:methods; D016031:Liver Transplantation / Q000379:methods; D011183:Postoperative Complications / Q000517:prevention & control; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D011507:Proteinuria / Q000209:etiology; D051437:Renal Insufficiency / Q000209:etiology / Q000517:prevention & control*; D020123:Sirolimus / Q000008:administration & dosage / Q000009:adverse effects; D058570:TOR Serine-Threonine Kinases
chemical_list: D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D047908:Intracellular Signaling Peptides and Proteins; D016572:Cyclosporine; C546842:MTOR protein, human; D017346:Protein Serine-Threonine Kinases; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus