title: A new anthraquinone derivative from the marine endophytic fungus Fusarium sp. (No. b77).
abstract: A new anthraquinone compound, 5-acetyl-2-methoxy-1,4,6-trihydroxy-anthraquinone (1), together with four known naphthoquinones (2-5), were isolated from the culture of the mangrove fungus (No. b77). All the isolated compounds (1-5) and the acetyl derivative (1a) were established by comprehensive analysis of the spectral data, especially 1D- and 2D-NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 showed strong inhibitory effects on the growth of hepG2 and hep2 cells, with IC(50) values of 1.0 and 2.5 microg mL(-1), respectively.
authors.affiliation: School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P.R. China.
authors.forename: Changlun
authors.initials: C
authors.lastname: Shao
authors.forename: Changyun
authors.initials: C
authors.lastname: Wang
authors.forename: Caijuan
authors.initials: C
authors.lastname: Zheng
authors.forename: Zhigang
authors.initials: Z
authors.lastname: She
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Gu
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000880:Anthraquinones / Q000737:chemistry* / Q000302:isolation & purification; D001681:Biological Assay; D003470:Culture Media / Q000737:chemistry; D005670:Fusarium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: C547247:5-acetyl-2-methoxy-1,4,6-trihydroxy-anthraquinone; D000880:Anthraquinones; D003470:Culture Media