title: Effects of metals on skin permeability barrier recovery.
abstract: We previously demonstrated that the electrical state of the skin surface influences epidermal permeability barrier homeostasis. At the interface between different materials, electrons are localized heterogeneously and induce electrical potential. In the present study, we evaluated the effects of metals on the barrier recovery. When we put pure gold plate on skin immediately after tape stripping, the barrier recovery rate was faster than the control. The acceleration of barrier recovery was blocked when the plate was earthed (grounded). When a plastic membrane was sandwiched between the plate and the skin, the recovery was delayed in comparison with the control. We then used a germanium diode to regulate the current flow between the plate and the earth. When the current was blocked, the barrier recovery was accelerated, but when the current was not blocked, the recovery was not accelerated. These results suggest that localization of electron might affect for the barrier recovery rate. The level of interfacial electric potential would be different due to the electrochemical property of metal. Thus, we next evaluated the effects of other metals. With samarium, zirconium, iridium and silver, the barrier recovery rate was faster than in the case of gold, while a platinum plate induced slower recovery than in the case of gold. There was a significant correlation between work function of each metal and barrier recovery rate. These results suggest that electron donation from outside accelerated the skin barrier recovery.
authors.affiliation: Shiseido Innovative Science Research & Development Center, Yokohama, Japan. mitsuhiro.denda@to.shiseido.co.jp
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Denda
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kumazawa
mesh_terms: D000818:Animals; D006046:Gold / Q000494:pharmacology; D006706:Homeostasis / Q000187:drug effects* / Q000502:physiology; D007495:Iridium / Q000494:pharmacology; D008297:Male; D008670:Metals / Q000494:pharmacology*; D051379:Mice; D008812:Mice, Hairless; D023421:Models, Animal; D010539:Permeability / Q000187:drug effects; D012493:Samarium / Q000494:pharmacology; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D015040:Zirconium / Q000494:pharmacology
chemical_list: D008670:Metals; D012493:Samarium; D007495:Iridium; D006046:Gold; D015040:Zirconium