Inhibition of Vascular Endothelial Growth Factor Receptor-1/Wnt/{beta}-catenin Crosstalk Leads to Tumor Cell Death.
Two genes are considered synthetic lethal if mutation of either alone allows cell viability, whereas simultaneous mutation leads to cell death. A synthetic lethal screen unveiled the dependency of Wnt/beta-catenin-addicted colorectal cancer cells on vascular endothelial growth factor receptor-1 kinase activity and suggested a novel therapeutic approach for this malignancy. (Clin Cancer Res 2009;15(24):7453-5).
Zeitlin
Benjamin D
BD
Authors' Affiliations: Angiogenesis Research Laboratory, Department of Restorative Sciences, School of Dentistry; Department of Biomedical Engineering, College of Engineering; Department of Otolaryngology, School of Medicine, University of Michigan, Ann Arbor, Michigan; and Departments of Surgical Oncology and Cancer Biology, Maryland Anderson Cancer Center, University of Texas, Houston, Texas.
Ellis
Lee M
LM
Nör
Jacques E
JE