title: Influence of up-regulated renin-angiotensin system on the exploration, anxiety-related behavior and object recognition.
abstract: The renin-angiotensin system (RAS) plays an important role in the development of hypertension and has serious consequences on behaviour. The aim of our study was to investigate the effect of hypertension, induced by up-regulated RAS, on the exploration, anxiety-related behaviour and object recognition in laboratory rats. In the experiment, 12 weeks old normotensive Sprague-Dawley (SD) and hypertensive TGR(mREN2)27 (TGR) male rats with up-regulated RAS were used. In the open-field test, the TGR rats were less active in ambulating, rearing and sniffing and more active in self-grooming and urinating than SD ones. In the elevated plus-maze test, the TGR rats showed lower frequency of total arm entries, closed arm entries and higher frequency of defecation than in controls. In the emergence test, TGR rats did not show significant differences. In the novel object recognition task, the TGR rats spent less time with exploration of both familiar and unfamiliar objects but preferred the novel object over the familiar one and exhibited higher percentage of the total exploring time spent with novel object exploration than SD rats. Our results indicate that the TGR rats are less actively exploring, show some modifications of emotional/anxiety-related behavior and exhibited better recognition abilities.
authors.affiliation: Comenius University Department of Animal Physiology and Ethology, Faculty of Natural Sciences 842 15 Bratislava Slovak Republic. krskova@fns.uniba.sk
authors.forename: Lucia
authors.initials: L
authors.lastname: Krsková
authors.forename: Michaela
authors.initials: M
authors.lastname: Vrabcová
authors.forename: Alzbeta
authors.initials: A
authors.lastname: Talarovicová
authors.forename: M
authors.initials: M
authors.lastname: Zeman
mesh_terms: D000818:Animals; D001007:Anxiety / Q000503:physiopathology*; D001522:Behavior, Animal / Q000502:physiology*; D004195:Disease Models, Animal; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology*; D008124:Locomotion / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D055647:Rats, Transgenic; D021641:Recognition, Psychology / Q000502:physiology*; D012083:Renin / Q000235:genetics / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000235:genetics / Q000502:physiology*; D015854:Up-Regulation; D014554:Urination / Q000502:physiology
chemical_list: C473112:Ren2 protein, mouse; D012083:Renin