Acetylcholinesterase inhibitory pyridine alkaloids of the leaves of Senna multijuga.
Two unusual pyridine alkaloids, 7'-multijuguinone (1) and 12'-hydroxy-7'-multijuguinone (2), were isolated from the leaves of Senna multijuga, together with the known flavonoid rutin. The structures of the new alkaloids were established on the basis of spectroscopic data interpretation. Compounds 1 and 2 exhibited moderate in vitro acetylcholinesterase (AChE) inhibitory activity, in comparison with the standard compound physostigmine.
Serrano
Maria A R
MA
Sao Paulo State University (UNESP), Araraquara, SP, Brazil.
Pivatto
Marcos
M
Francisco
Welington
W
Danuello
Amanda
A
Regasini
Luis O
LO
Lopes
Elaine M C
EM
Lopes
Marcia N
MN
Young
Maria C M
MC
Bolzani
Vanderlan S
VS
D000110:Acetylcholinesterase / Q000378:metabolism*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001938:Brazil; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029846:Senna Plant / Q000737:chemistry*
C548944:12'-hydroxy-7'-multijuguinone; C548943:7'-multijuguinone; D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D011725:Pyridines; D000110:Acetylcholinesterase