From meiosis to postmeiotic events: the secrets of histone disappearance.
One of the most obscure phenomena in modern biology is the near genome-wide displacement of histones that occurs during the postmeiotic phases of spermatogenesis in many species. Here we review the literature to show that, during spermatogenic differentiation, three major molecular mechanisms come together to 'prepare' the nucleosomes for facilitated disassembly and histone removal.
Gaucher
Jonathan
J
INSERM, U823, Université Joseph Fourier, Institut Albert Bonniot, Grenoble, France.
Reynoird
Nicolas
N
Montellier
Emilie
E
Boussouar
Fayçal
F
Rousseaux
Sophie
S
Khochbin
Saadi
S
D000107:Acetylation; D000818:Animals; D002843:Chromatin / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology; D006655:Histone Deacetylases / Q000235:genetics; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008297:Male; D008540:Meiosis / Q000502:physiology*; D051379:Mice; D009707:Nucleosomes / Q000187:drug effects / Q000378:metabolism*; D011479:Protamines / Q000378:metabolism; D013087:Spermatids / Q000378:metabolism; D013091:Spermatogenesis / Q000235:genetics
D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; D009707:Nucleosomes; D011479:Protamines; C053886:spermatid transition proteins; D006655:Histone Deacetylases