The Midas touch in cancer chemotherapy: from platinum- to gold-dithiocarbamato complexes.
The unquestionable therapeutic success of the anticancer drug cisplatin and its second- and third-generation analogues has triggered, in the past forty years, the development of several metal-based potential chemotherapeutic agents, most of which have failed to enter clinical trials. In this context, during the last decade, our research group has been making quite an effort to design a number of metal-dithiocarbamato derivatives that were expected, at least in principle, to resemble the main features of cisplatin together with higher activity, improved selectivity and bioavailability, and lower side-effects. Among all, gold(III) complexes have shown outstanding in vitro and in vivo antitumour properties and reduced or no systemic and renal toxicity, compared to the reference drug. Here, we summarize the results achieved to date, focusing on the mechanistic studies and the potential future developments opened up by our research work.
Ronconi
Luca
L
Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131, Padova, Italy. luca.ronconi@unipd.it
Fregona
Dolores
D
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D006046:Gold / Q000737:chemistry*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D010984:Platinum / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry; D013859:Thiocarbamates / Q000737:chemistry*
D000970:Antineoplastic Agents; D056831:Coordination Complexes; D013859:Thiocarbamates; D010984:Platinum; D006046:Gold; D012428:Ruthenium