title: [Impact of a health safety warning on strontium ranelate utilization].
abstract: OBJECTIVE
  To evaluate changes in the use of strontium ranelate following a health safety warning in November 2007 on the risks of the development of DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) with the use of this medicine.
  
  
  METHODS
  Monthly strontium ranelate DHD (daily defined doses/1,000 inhabitants/day) were calculated between 2006 and 2008 in a health area of Spain. The data were analyzed graphically and through a multiple regression model.
  
  
  RESULTS
  Graphical representation showed a long-term rising trend throughout the study period, although growth slowed after the safety warning was issued. The multiple regression model showed that the health warning was statistically significant.
  
  
  CONCLUSIONS
  The use of strontium ranelate continues to grow after the issue of the health safety warning, although at a slower pace than previously.
authors.affiliation: Area Sanitaria de Santiago de Compostela, Servicio Gallego de Salud, Santiago de Compostela, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Carracedo-Martínez
authors.forename: Agustín
authors.initials: A
authors.lastname: Pía-Morandeira
mesh_terms: D004363:Drug Utilization / Q000706:statistics & numerical data; D006801:Humans; D050316:Medical Order Entry Systems; D009942:Organometallic Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies; D012449:Safety; D013030:Spain; D013876:Thiophenes / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D009942:Organometallic Compounds; D013876:Thiophenes; C081587:strontium ranelate