title: Very preterm birth is a risk factor for increased systolic blood pressure at a young adult age.
abstract: Children born very prematurely who show intrauterine growth retardation (IUGR) are suggested to be at risk of developing high blood pressure as adults. Renal function may already be impaired by young adult age. To study whether very preterm birth affects blood pressure in young adults, we measured 24-h ambulatory blood pressure (Spacelabs 90207 device) and renin concentration in 50 very premature individuals (<32 weeks of gestation), either small (SGA) or appropriate (AGA) for gestational age (21 SGA, 29 AGA), and 30 full-term controls who all were aged 20 years at time of measurement. The mean (standard deviation) daytime systolic blood pressure in SGA and AGA prematurely born individuals, respectively, was 122.7 (8.7) and 123.1 (8.5) mmHg. These values were, respectively, 3.6 mmHg [95% confidence interval (CI) -0.9 to 8.0] and 4.2 mmHg (95% CI 0.4-8.0) higher than in controls [119.6 (7.6)]. Daytime diastolic blood pressure and nighttime blood pressure did not differ between groups. We conclude that individuals born very preterm have higher daytime systolic blood pressure and higher risk of hypertension at a young adult age.
authors.affiliation: Department of Pediatric Nephrology, Erasmus MC - Sophia Children's Hospital, University Medical Center Rotterdam, P.O. Box 2060, 3000 CB, Rotterdam, The Netherlands. m.keijzer-veen@erasmusmc.nl
authors.forename: Mandy G
authors.initials: MG
authors.lastname: Keijzer-Veen
authors.forename: Arzu
authors.initials: A
authors.lastname: Dülger
authors.forename: Friedo W
authors.initials: FW
authors.lastname: Dekker
authors.forename: Jeroen
authors.initials: J
authors.lastname: Nauta
authors.forename: Bert J
authors.initials: BJ
authors.lastname: van der Heijden
mesh_terms: D001724:Birth Weight / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D001827:Body Height; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000503:physiopathology; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007236:Infant, Small for Gestational Age; D007668:Kidney / Q000473:pathology; D007677:Kidney Function Tests; D008297:Male; D009929:Organ Size / Q000502:physiology; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult