title: Biochemical and histopathological evidences for beneficial effects of satureja khuzestanica jamzad essential oil on the mouse model of inflammatory bowel diseases.
abstract: The essential oil from Satureja Khuzestanica Jamzad (SKEO), an endemic plant from Iran, was evaluated for its activity against inflammatory bowel disease (IBD). SKEO was examined on the experimental mouse model of inflammatory bowel disease, which is acetic acid-induced colitis. Prednisolone was used as the standard drug for comparison. Biochemical, macroscopic, and microscopic examinations of colon were performed. Lipid peroxidation significantly increased in acetic acid-treated mice in comparison to the normal group (4.88 vs. 3.02 mumol/g) and was significantly restored by SKEO (500, 1000, 1500 ppm) and prednisolone treatment. The mean percentage of decreases of lipid peroxidation in SKEO (500, 1000, 1500 ppm)- and prednisolone-treated groups were 10.5, 28.5, 42.85, and 33.33 of control, respectively. The myeloperoxidase activity significantly increased in acetic acid-treated mice in comparison to the normal group (4.1 vs. 0.8 U/g) and significantly restored in SKEO (1000 and 1500 ppm)- and prednisolone-treated groups. The mean percentage of decreases of myeloperoxidase activity in SKEO (1000 and 1500 ppm)- and prednisolone-treated groups were 24.56, 50, and 52.63 of control, respectively. SKEO (1000 and 1500 ppm)- and prednisolone-treated groups showed significantly lower score values of macroscopic and microscopic characters when compared to the acetic acid-treated group. The beneficial effect of SKEO (1500 ppm) was comparable to that of prednisolone. Known antioxidant, antimicrobial, antiinflammatory, and antispasmodic potentials of Satureja Khuzestanica may be the mechanisms by which this plant protects animals against experimentally induced IBD. Proper clinical investigation should be carried out to confirm the activity in human disease.
authors.affiliation: Laboratory of Toxicology, Department of Toxicology & Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ghazal
authors.initials: G
authors.lastname: Ghazanfari
authors.forename: Bagher
authors.initials: B
authors.lastname: Minaie
authors.forename: Narges
authors.initials: N
authors.lastname: Yasa
authors.forename: Leila Ashtaral
authors.initials: LA
authors.lastname: Nakhai
authors.forename: Azadeh
authors.initials: A
authors.lastname: Mohammadirad
authors.forename: Shekoufeh
authors.initials: S
authors.lastname: Nikfar
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Dehghan
authors.forename: Vahid Shetab
authors.initials: VS
authors.lastname: Boushehri
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Jamshidi
authors.forename: Reza
authors.initials: R
authors.lastname: Khorasani
authors.forename: Alinazar
authors.initials: A
authors.lastname: Salehnia
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi