Cardiac diastolic dysfunction and metabolic syndrome in young women after placental syndrome.
OBJECTIVE
To estimate whether women with a recent history of a placental syndrome and concomitant metabolic syndrome have reduced cardiac diastolic function.


METHODS
In this cohort study, women with a history of a placental syndrome were included. We assessed body mass index, blood pressure, fasting serum lipids, glucose and insulin levels, and 24-hour urinary protein and albumin output after an interval of at least 6 months postpartum. Cardiac diastolic function was assessed by echocardiography.


RESULTS
Metabolic syndrome was found in 22% of the women evaluated. Diastolic dysfunction was seen in 24% of the women with the metabolic syndrome compared with 6.3% in those without (odds ratio 4.77, 95% confidence interval 2.18-10.41; adjusted odds ratio 6.09, 95% confidence interval 2.64-14.04). Univariable analysis showed that all the constituents of the metabolic syndrome related to diastolic dysfunction.


CONCLUSIONS
In women with a history of placental syndrome complicating pregnancy, the presence of metabolic syndrome increases the risk of cardiac diastolic dysfunction fourfold.


METHODS
II.
Zandstra
Mirjam
M
From the Departments of Obstetrics and Gynecology and Cardiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Stekkinger
Eva
E
van der Vlugt
Maureen J
MJ
van Dijk
Arie P
AP
Lotgering
Frederik K
FK
Spaanderman
Marc E A
MEA
D000328:Adult; D015897:Comorbidity; D003971:Diastole / Q000502:physiology; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology; D006801:Humans; D006946:Hyperinsulinism / Q000453:epidemiology; D024821:Metabolic Syndrome; D010922:Placenta Diseases / Q000453:epidemiology* / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D011379:Prognosis; D018754:Ventricular Dysfunction / Q000453:epidemiology* / Q000503:physiopathology*