Highly enantioselective synthesis of tertiary alcohols: C2-symmetric N,N'-dioxide-Sc(III) complex promoted direct aldol reaction of alpha-ketoesters and diazoacetate esters.
A C(2)-symmetric N,N'-dioxide-Sc(III) complex has been developed to promote the asymmetric catalytic aldol reaction of alpha-ketoesters and diazoacetate esters to afford tertiary alcohols in good yields with excellent enantioselectivities.
Wang
Fei
F
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
Liu
Xiaohua
X
Zhang
Yulong
Y
Lin
Lili
L
Feng
Xiaoming
X