title: Synthesis and antileishmanial activity of lipidic amino alcohols.
abstract: In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC(50) below 10 microm. Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms.
authors.affiliation: Departamento de Parasitologia, Microbiologia e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Cidade Universitária, MG, Brazil.
authors.forename: Elaine S
authors.initials: ES
authors.lastname: Coimbra
authors.forename: Mauro V
authors.initials: MV
authors.lastname: de Almeida
authors.forename: Celso O R
authors.initials: CO
authors.lastname: Júnior
authors.forename: Aline F
authors.initials: AF
authors.lastname: Taveira
authors.forename: Cristiane F
authors.initials: CF
authors.lastname: da Costa
authors.forename: Ana C
authors.initials: AC
authors.lastname: de Almeida
authors.forename: Elaine F C
authors.initials: EF
authors.lastname: Reis
authors.forename: Adilson D
authors.initials: AD
authors.lastname: da Silva
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000666:Amphotericin B / Q000494:pharmacology; D006801:Humans; D007891:Leishmania / Q000187:drug effects* / Q000254:growth & development; D014344:Trypanocidal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000605:Amino Alcohols; D014344:Trypanocidal Agents; D000666:Amphotericin B