title: Separation anxiety: detachment from the extracellular matrix induces metabolic changes that can stimulate tumorigenesis.
abstract: One of the earliest stages of tumor progression involves the ability of cells to survive and proliferate when not attached to the extracellular matrix (ECM). New research using a physiologically relevant breast cancer model reveals how separation from the ECM stimulates metabolic changes characteristic of developing tumors.
authors.affiliation: Mayo Clinic Cancer Center, Jacksonville, FL 32225, USA.
authors.forename: Magdalena A
authors.initials: MA
authors.lastname: Cichon
authors.forename: Derek C
authors.initials: DC
authors.lastname: Radisky
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D002460:Cell Line; D002470:Cell Survival; D018450:Disease Progression; D005109:Extracellular Matrix / Q000378:metabolism*; D005260:Female; D006801:Humans; D009857:Oncogenes; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species