Subdural fluid collections in patients with infantile neuronal ceroid lipofuscinosis.
OBJECTIVE
To describe subdural fluid collections on magnetic resonance imaging as part of the natural history of infantile neuronal ceroid lipofuscinosis.


METHODS
Case series.


METHODS
Program on Developmental Endocrinology and Genetics, The Clinical Center, National Institutes of Health, Bethesda, Maryland.


METHODS
Patients with infantile neuronal ceroid lipofuscinosis with subdural fluid collections.


METHODS
Neurodegeneration on magnetic resonance imaging.


RESULTS
During an ongoing bench-to-bedside clinical investigation, magnetic resonance imaging examinations led to the incidental discovery of subdural fluid collections in 4 of 9 patients with infantile neuronal ceroid lipofuscinosis. No particular event (such as trauma) or change in symptoms was linked to this finding, which was already in the chronic phase when discovered. Of the 4 patients, 1 was followed up for 7 years, 2 for 4 years, and 1 for 2.5 years. Over time, these collections remained stable or decreased in size.


CONCLUSIONS
Recognition that subdural fluid collections are part of the infantile neuronal ceroid lipofuscinosis disease process may obviate the necessity of additional workup as well as therapeutic interventions in these chronically sick children.
Levin
Sondra W
SW
Department of Pediatrics,Walter Reed Army Medical Center, Washington, DC, USA.
Baker
Eva H
EH
Gropman
Andrea
A
Quezado
Zenaide
Z
Miao
Ning
N
Zhang
Zhongjian
Z
Jollands
Alice
A
Di Capua
Matteo
M
Caruso
Rafael
R
Mukherjee
Anil B
AB
D002648:Child; D006801:Humans; D009472:Neuronal Ceroid-Lipofuscinoses / Q000150:complications* / Q000175:diagnosis*; D013353:Subdural Effusion / Q000150:complications* / Q000175:diagnosis*; D013355:Subdural Space / Q000473:pathology