IVF outcome in women with PCOS, PCO and normal ovarian morphology.
OBJECTIVE
To examine the outcome of IVF in women who have normal ovaries, ovulatory PCO or PCOS.


METHODS
Analysis of a prospectively collected database in an assisted conception unit in a university teaching hospital including 290 women <37 years of age undergoing their first IVF cycle. The main outcome measure was severe OHSS requiring hospitalization.


RESULTS
Severe OHSS rates were significantly higher in women with PCO (12.6%) and PCOS (15.4%) compared to those with normal ovaries (2.7%). Coasting was used significantly more often. Live birth rates per cycle started are similar among women with PCO (38%), PCOS (37%) and normal ovaries (40%).


CONCLUSIONS
Women with ovaries of polycystic morphology are at increased risk of developing severe OHSS and of requiring avoidance techniques such as coasting, regardless of ovulatory status. However, live birth rates per cycle are similar to women with normal ovaries.
Swanton
Alexander
A
Royal Berkshire Hospital, Reading, RG1 5AN, UK.
Story
Lisa
L
Oxford Fertility Unit, Institute of Reproductive Sciences, Oxford Business Park North, Oxford, Oxfordshire, OX4 2HW, UK.
McVeigh
Enda
E
Oxford Fertility Unit, Institute of Reproductive Sciences, Oxford Business Park North, Oxford, Oxfordshire, OX4 2HW, UK.
Child
Tim
T
Oxford Fertility Unit, Institute of Reproductive Sciences, Oxford Business Park North, Oxford, Oxfordshire, OX4 2HW, UK. Electronic address: tim.child@obs-gyn.ox.ac.uk.
D000328:Adult; D016208:Databases, Factual; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D016471:Ovarian Hyperstimulation Syndrome / Q000000981:diagnostic imaging / Q000209:etiology*; D010053:Ovary / Q000000981:diagnostic imaging*; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000000981:diagnostic imaging; D011446:Prospective Studies; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D014463:Ultrasonography