The roles of tetraspanins in HIV-1 replication.
Tetraspanins are small integral membrane proteins that are known to control a variety of cellular processes, including signaling, migration and cell-cell fusion. Research over the past few years established that they are also regulators of various steps in the HIV-1 replication cycle, but the mechanisms through which these proteins either enhance or repress virus spread remain largely unknown.
Thali
Markus
M
Department of Microbiology and Molecular Genetics, College of Medicine and CALS, University of Vermont, 318 Stafford Hall, 95 Carrigan Drive, Burlington, VT 05405-0084, USA. markus.thali@uvm.edu
D000818:Animals; D015703:Antigens, CD / Q000502:physiology*; D015497:HIV-1 / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D010980:Platelet Membrane Glycoproteins / Q000502:physiology*; D060225:Tetraspanin 28; D060245:Tetraspanin 29; D060149:Tetraspanin 30; D014158:Transcription, Genetic; D053586:Virus Internalization; D014779:Virus Replication
D015703:Antigens, CD; C554586:CD63 protein, human; C554798:CD81 protein, human; C554869:CD9 protein, human; D008562:Membrane Glycoproteins; D010980:Platelet Membrane Glycoproteins; D060225:Tetraspanin 28; D060245:Tetraspanin 29; D060149:Tetraspanin 30