title: [Association of serotonin and norepinephrine transporter gene polymorphisms with the susceptibility to depression].
abstract: OBJECTIVE
  To determine whether the serotonin transporter (5-HTT) and norepinephrine transporter (NET) gene polymorphisms were associated with the susceptibility to depression.
  
  
  METHODS
  Five hundred and seventy-nine patients with depression, evaluated using a 17-item Hamilton Depression Rating Scale for Depression (HAMD), and 437 healthy controls, all of Chinese Han origin, were genotyped by polymerase chain reaction.
  
  
  RESULTS
  Both genotype distributions (P=0.033) and allele frequencies (P=0.023, OR = 1.250, 95% CI = 1.031-1.517) of NET-T182C were significantly different between patients and controls, where the T allele was associated with the onset of depression. Both NET-T182C T- and 5- HTTLPR L-carriers had higher baseline HAMD scores (P=0.032 and 0.023, respectively). There was an interaction between NET-T182C and 5-HTTLPR, where the combined genotype distributions were associated with both onset of depression (P=0.006) and the baseline HAMD scores (P=0.007).
  
  
  CONCLUSIONS
  This study suggested a positive relationship between the NET-T182C polymorphism and the susceptibility to depression, and a positive relationship between NET-T182C/5-HTTLPR polymorphisms and the severity of depression.
authors.affiliation: Center for Psychological Health, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P.R. China.
authors.forename: Wen-jiao
authors.initials: WJ
authors.lastname: Min
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Ma
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Xue-li
authors.initials: XL
authors.lastname: Sun
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003863:Depression / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: D050484:Norepinephrine Plasma Membrane Transport Proteins; D050486:Serotonin Plasma Membrane Transport Proteins