title: Botulinium toxin, as bridge to transanal pullthrough in neonate with Hirschsprungs disease.
abstract: OBJECTIVE
  The aim of this study is to find easier way of home care while obviating the colostomy before single stage pull through operation.
  
  
  METHODS
  From August 2005 to December 2006, eight cases of neonatal Hirschsprung disease were treated. Mean age 4.5 (2-6) day/old with absent anorectal inhibitory reflex, rectosigmiod disease in Barium enema, positive Acetylcholine esterase (Ache) staining, good response to rectal washout. They underwent botulinium toxin injection (5 unit /kg/quadrant) in four quadrant intrasphincteric. They were followed until pull through operation in 8-10 weeks post injection.
  
  
  RESULTS
  Four of 8 (50%) cases only needed rectal washout for three to five days post injection until pull through operation, two had decrease in number of rectal washouts /day and the remaining two underwent colostomy five days post injection because of no response.
  
  
  CONCLUSIONS
  Botulinium toxin injection can help in palliative care in patients with Hirschsprung disease who are waiting for colostomy or definitive pullthrough. It gives an option of eaiser home care for these patients.
authors.affiliation: Department of Pediatric Surgery, Shiraz University Medical Science, Shiraz, Iran.
authors.forename: S M V
authors.initials: SM
authors.lastname: Hosseini
authors.forename: H R
authors.initials: HR
authors.lastname: Foroutan
authors.forename: S
authors.initials: S
authors.lastname: Zeraatian
authors.forename: B
authors.initials: B
authors.lastname: Sabet