Chemosensory organs as models of neuronal synapses.
Neuronal synapses are important microstructures that underlie complex cognitive capacities. Recent studies, primarily in Caenorhabditis elegans and Drosophila melanogaster, have revealed surprising parallels between these synapses and the 'chemosensory synapses' that reside at the tips of chemosensory cells that respond to environmental stimuli. Similarities in the structures, mechanisms of action and specific molecules found at these sites extend to the presynaptic, postsynaptic and glial entities composing both synapse types. In this article I propose that chemosensory synapses may serve as useful models of neuronal synapses, and consider the possibility that the two synapse types derive from a common ancestral structure.
Shaham
Shai
S
Laboratory of Developmental Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. shaham@rockefeller.edu
D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology; D004331:Drosophila melanogaster / Q000502:physiology; D009415:Nerve Net / Q000502:physiology*; D009457:Neuroglia / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology*