title: Adrenal failure caused by a retroperitoneal malignant mesothelioma.
abstract: A 62-year-old man presented with clinical signs of acute abdominal pain and adrenal insufficiency. Computerized tomographic scans revealed bilateral adrenal tumors and the left adrenal tumor was surgically resected. The patient was found to have retroperitoneal mesothelioma presenting as bilateral metastatic adrenal tumors, which were well controlled by systemic chemotherapy with CDDP and 5-FU. This case appears to be the first reported case in the literature of adrenal failure due to bilateral adrenal infiltration caused by retroperitoneal malignant mesothelioma.
authors.affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University. nomura@med.kyushu-u.ac.jp
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Nomura
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sasano
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Okada
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Watanabe
authors.forename: Shohei
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Sakiyama
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Sakamoto
authors.forename: Ichiro
authors.initials: I
authors.lastname: Abe
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Horiuchi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yanase
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Takayanagi
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D000309:Adrenal Insufficiency / Q000209:etiology*; D000971:Antineoplastic Combined Chemotherapy Protocols; D002945:Cisplatin / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D008875:Middle Aged; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*
chemical_list: D002945:Cisplatin; D005472:Fluorouracil