[Trisomy 8 in chronic lymphocytic leukemia].
OBJECTIVE
To investigate the incidence of trisomy 8 in chronic lymphocytic leukemia (CLL) and its significance in prognosis.


METHODS
A panel of probes and fluorescence in situ hybridization (FISH) were used to detect trisomy 8 in 151 CLL patients combined with chromosome karyotype analysis.


RESULTS
There were 2 patients (1.3%) with trisomy 8 in the 151 CLL patients, and the number of trisomy 8 cells was 8% and 10% respectively. The karyotypes were 47,XY,+8[2]/49,XY,+14,+20,+21[2]/ 46,XY[16], and 47,XX,+8[2]/46,XX[18], respectively.


CONCLUSIONS
Trisomy 8 was rare in CLL, and its significance in prognosis of CLL still remains unknown.
Cao
Xin
X
Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029 P.R. China.
Xu
Wei
W
Liu
Qiong
Q
Zhu
Dan-xia
DX
Qiao
Chun
C
Wu
Yu-jie
YJ
Qiu
Hong-xia
HX
Li
Jian-yong
JY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014314:Trisomy