Association between SOD2 T-9C and MTHFR C677T polymorphisms and longevity: a study in Jordanian population.
BACKGROUND
Aging in animals is associated with high body oxidative stress, which might affect susceptibility and onset of age-related diseases, and the subsequent life span. Therefore, genes that modulate oxidative stress might play a role in determining longevity. In this study, we investigated whether the gene pool relevant to the SOD2-9T/C and MTHFR 677C/T polymorphisms changes as the Jordanian population ages.


METHODS
Polymorphisms were genotyped in 130 elderly subjects (57 females and 73 males, mean age: 90.01 years) and 135 young control subjects (67 females and 68 males, mean age: 33.43 years).


RESULTS
No significant differences were found in the genotype and allele frequencies of examined SOD2 and MTHFR gene variants between the elderly group and young controls (P > 0.05), nor when each gender was considered separately (P > 0.05).


CONCLUSIONS
SOD2-9T/C and MTHFR 677C/T gene polymorphisms do not seem to be important in Jordanian population for longevity phenotype.
Khabour
Omar F
OF
Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan. khabour@just.edu.jo
Abdelhalim
Essa S
ES
Abu-Wardeh
Ahmad
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018912:Arabs / Q000235:genetics* / Q000706:statistics & numerical data; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006801:Humans; D007597:Jordan; D008136:Longevity / Q000235:genetics*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013482:Superoxide Dismutase / Q000235:genetics*; D055815:Young Adult; D000099156:Superoxide Dismutase 2
D042965:Methylenetetrahydrofolate Reductase (NADPH2); D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2