Modern lipid-, carbohydrate-, and peptide-based delivery systems for peptide, vaccine, and gene products.
Research related to peptide, vaccine, and gene delivery has grown exponentially over the last decade. In this review, we discuss the development of delivery systems for peptides, gene and vaccine products. Special focus is given to different lipidation and glycosylation strategies to improve the metabolic stability and membrane permeability of therapeutics, and their targeting to specific sites. The synthetic methods for preparation of the systems are also described.
Simerska
Pavla
P
School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, Australia.
Moyle
Peter M
PM
Toth
Istvan
I
D000818:Animals; D002241:Carbohydrates / Q000737:chemistry*; D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry*; D014612:Vaccines / Q000008:administration & dosage*
D002241:Carbohydrates; D008055:Lipids; D010455:Peptides; D014612:Vaccines