A new class of spinal interneurons: the origin and function of C boutons is solved.
C boutons, a major synaptic input to motor neurons, were first described years ago, but their origin and functional significance were unknown. In this issue of Neuron, a group of cholinergic interneurons located near the central canal is identified as the source of C boutons. The rhythmic activity in these neurons during locomotion increases motor neuronal excitability, thereby potentiating the strength of muscle contraction.
Frank
Eric
E
Department of Physiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA. eric.frank@tufts.edu
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D007839:Functional Laterality; D006801:Humans; D007395:Interneurons / Q000166:cytology / Q000502:physiology*; D008124:Locomotion / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D017729:Presynaptic Terminals / Q000502:physiology*; D013116:Spinal Cord / Q000166:cytology*
D000109:Acetylcholine