title: [Optimization of riboflavin sodium phosphate loading to calcium alginate floating microspheres by response surface methodology].
abstract: OBJECTIVE
  To investigate the preparation, optimization and in vitro properties of riboflavin sodium phosphate floating microspheres.
  
  
  METHODS
  The floating microspheres composed of riboflavin sodium phosphate and calcium alginate were prepared using ion gelatin-oven drying method.
  
  
  RESULTS
  The properties of the microspheres were investigated, including the buoyancy, release, appearance and entrapment efficiency. The formulation was optimized by response surface methodology (RSM).
  
  
  CONCLUSIONS
  The optimized microspheres were round. The entrapment efficiency was 57.49%. All the microspheres could float on the artificial gastric juice over 8 hours. The release of the drug from the microspheres complied with Fick's diffusion.
authors.affiliation: Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100191, China.
authors.forename: An-yang
authors.initials: AY
authors.lastname: Zhang
authors.forename: Tian-yuan
authors.initials: TY
authors.lastname: Fan
mesh_terms: D000464:Alginates / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008863:Microspheres; D010710:Phosphates / Q000737:chemistry*; D012256:Riboflavin / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000464:Alginates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D010710:Phosphates; D020723:Glucuronic Acid; C018279:sodium phosphate; D012256:Riboflavin