title: Outbreak of skin infections in college football team members due to an unusual strain of community-acquired methicillin-susceptible Staphylococcus aureus.
abstract: We report a skin and soft-tissue infection outbreak among football team members due to a USA300 methicillin-susceptible Staphylococcus aureus (MRSA) strain with genes coding for Panton-Valentine leukocidin and the arginine catabolic mobile element. We postulate that the strain is a community-associated USA300 MRSA strain that lost methicillin resistance but retained important virulence factors.
authors.affiliation: Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA. jmfontanilla@yahoo.com
authors.forename: Jose-Mario
authors.initials: JM
authors.lastname: Fontanilla
authors.forename: Kathryn B
authors.initials: KB
authors.lastname: Kirkland
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Talbot
authors.forename: Kenton E
authors.initials: KE
authors.lastname: Powell
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Schwartzman
authors.forename: Richard V
authors.initials: RV
authors.lastname: Goering
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Parsonnet
mesh_terms: D056352:Athletes; D001426:Bacterial Proteins / Q000235:genetics; D001427:Bacterial Toxins / Q000235:genetics; D015373:Bacterial Typing Techniques; D017714:Community-Acquired Infections / Q000453:epidemiology* / Q000382:microbiology; D016172:DNA Fingerprinting; D004196:Disease Outbreaks; D016521:Electrophoresis, Gel, Pulsed-Field; D005098:Exotoxins / Q000235:genetics; D006801:Humans; D020071:Interspersed Repetitive Sequences; D007956:Leukocidins / Q000235:genetics; D008297:Male; D016106:Methicillin Resistance; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D013207:Staphylococcal Skin Infections / Q000453:epidemiology* / Q000382:microbiology; D013334:Students; D037521:Virulence Factors / Q000235:genetics; D055815:Young Adult
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D037521:Virulence Factors