title: Treatment of articular cartilage lesions of the knee joint using a modified AMIC technique.
abstract: This study describes a modified AMIC technique consisting of perforations according to Pridie, rather than microfractures, and the covering of the focus of the lesion with a biological collagen patch enriched with bone marrow blood drawn through the knee itself. This technique allows advantages of both the Pridie technique and the in situ proliferation of mesenchymal cells beneath a biological collagen membrane, 'augmented', with bone marrow blood. The collagen membrane forms the roof of a 'biological chamber', and serves to protect and contains the stem cells as they differentiate into chondrocytes, which will form a healthy regenerative cartilage.
authors.affiliation: Laboratorio di Chirurgia Artroscopica, Via Teodoro La Cava 36, Isernia, Italy. pascarel@tin.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Pascarella
authors.forename: Riccardo
authors.initials: R
authors.lastname: Ciatti
authors.forename: Fabio
authors.initials: F
authors.lastname: Pascarella
authors.forename: Carmine
authors.initials: C
authors.lastname: Latte
authors.forename: Mariano Giuseppe
authors.initials: MG
authors.lastname: Di Salvatore
authors.forename: Luciano
authors.initials: L
authors.lastname: Liguori
authors.forename: Germano
authors.initials: G
authors.lastname: Iannella
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000379:methods; D002356:Cartilage / Q000293:injuries* / Q000502:physiology / Q000601:surgery; D019902:Chondrocytes / Q000637:transplantation*; D003094:Collagen / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007718:Knee Injuries / Q000601:surgery; D007719:Knee Joint; D008279:Magnetic Resonance Imaging; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D008875:Middle Aged; D012038:Regeneration; D055815:Young Adult
chemical_list: D003094:Collagen