Adaptations of proteins to cellular and subcellular pH.
Bioinformatics-based searches for correlations between subcellular localization and pI or charge distribution of proteins have failed to detect meaningful correlations. Recent work published in BMC Biology finds that a physicochemical metric of charge distribution correlates better with subcellular pH than does pI. See research article http://www.biomedcentral.com/1741-7007/7/69.
Garcia-Moreno
Bertrand
B
Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA. bertrand@jhu.edu
D000220:Adaptation, Biological / Q000502:physiology*; D000818:Animals; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007425:Intracellular Membranes / Q000737:chemistry / Q000502:physiology*; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology*; D013347:Subcellular Fractions / Q000737:chemistry / Q000502:physiology*
D008565:Membrane Proteins