Towards an asymmetric synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin.
Studies towards the synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin are reported. The synthetic approach features an organocatalytic access to the alpha,alpha-disubstituted amino acid unit and results in the synthesis of an advanced intermediate which already contains all functionalities of fumimycin.
Hartmann
Caroline E
CE
Institut für Organische Chemie, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany.
Gross
Patrick J
PJ
Nieger
Martin
M
Bräse
Stefan
S
D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D000596:Amino Acids / Q000737:chemistry; D001572:Benzofurans / Q000138:chemical synthesis*
D000596:Amino Acids; D001572:Benzofurans; C522224:fumimycin; D000581:Amidohydrolases; C084507:peptide deformylase