title: [Novel MYBPC3 mutations in Chinese patients with hypertrophic cardiomyopathy].
abstract: OBJECTIVE
  To screen the MYBPC3 gene mutations in Han Chinese patients with hypertrophic cardiomyopathy (HCM).
  
  
  METHODS
  Sixty-six patients with HCM were enrolled for the study. The exons in the functional regions of MYBPC3 were amplified with PCR and the products were sequenced.
  
  
  RESULTS
  Four novel mutations and four common polymorphisms were identified in this patient cohort. A Lys301fs mutation in exon10 was evidenced in a H30, and when he was 47 years old, he had the chest tightness, shortness of breath with septal hypertrophy of 18.7mm; a Asp463stop mutation in exon17 was detected in a H48, he was 24 years old 24-year-old when a medical examination showed ventricular septal hypertrophy of 15.4 mm; both Gly523Arg mutation in exon18 and Tyr847His mutation in exon26 were found in a H53 with onset age 36 years old, feeling chest tightness after excise and his ventricular septal hypertrophy was 27 mm that time. MYBPC3 mutations occurred in 4.5% patients in this cohort. These mutations were not found in 100 non-HCM control patients.
  
  
  CONCLUSIONS
  MYBPC3 mutation is presented in a small portion of Han Chinese patients with HCM.
authors.affiliation: Department of Cardiology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Zhan-feng
authors.initials: ZF
authors.lastname: Ma
authors.forename: Wen-ling
authors.initials: WL
authors.lastname: Liu
authors.forename: Da-yi
authors.initials: DY
authors.lastname: Hu
authors.forename: Wen-li
authors.initials: WL
authors.lastname: Xie
authors.forename: Tian-gang
authors.initials: TG
authors.lastname: Zhu
authors.forename: Yi-hong
authors.initials: YH
authors.lastname: Sun
authors.forename: Song-na
authors.initials: SN
authors.lastname: Yang
authors.forename: Cui-lan
authors.initials: CL
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Xiao-yun
authors.initials: XY
authors.lastname: Nie
authors.forename: Jin-gang
authors.initials: JG
authors.lastname: Yang
authors.forename: Tian-chang
authors.initials: TC
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Bian
authors.forename: Qi-guang
authors.initials: QG
authors.lastname: Tong
authors.forename: Jie
authors.initials: J
authors.lastname: Xiao
authors.forename: Guo-hong
authors.initials: GH
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.forename: Rui-yun
authors.initials: RY
authors.lastname: Fan
authors.forename: Yun-tian
authors.initials: YT
authors.lastname: Li
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D002312:Cardiomyopathy, Hypertrophic / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D004252:DNA Mutational Analysis; D005091:Exons; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010641:Phenotype; D012333:RNA, Messenger / Q000235:genetics; D000099163:Myosin Binding Protein C
chemical_list: D002352:Carrier Proteins; D012333:RNA, Messenger; D000099163:Myosin Binding Protein C