title: Proton magnetic resonance spectroscopy imaging in the study of human brain cancer.
abstract: Magnetic resonance spectroscopic imaging (MRSI) is a non-invasive imaging technique that provides metabolic information on brain tumor. This biochemical information can be processed and presented as density maps of several metabolites, among them N-acetylaspartate (marker of neuronal viability), choline (marker of membrane turnover), creatine (related to the energy state of the cells), myo-Inositol (exclusively found in astrocytes), lipids and lactate (observed in necrosis and other pathological processes) which mean relevant information in the context of brain tumors. Thus, this technique is a multiparametrical molecular imaging method that can complete the magnetic resonance imaging (MRI) study enabling the detection of biochemical patterns of different features and aspects of brain tumors. In this article, the role of MRSI as a molecular imaging technique to provide biochemical information on human brain tumors is reviewed. The most frequent questions and situations in the study of human brain tumors in clinical settings will be considered, as well as the distinction of neoplastic lesions from non neoplastic, the tumor type identification, the study of heterogeneity and infiltration of normal appearing white matter and the therapy following with detection of side effects. The great amount of data in MRSI acquisition compared to the single voxel techniques requires the use of automated methods of quantification, but the possibility to obtain self-reference in the non-affected areas allows different strategies for data handling and interpretation, as presented in the literature. The combination of MRSI with other physiological MRI techniques and positron emission tomography is also included in this review.
authors.affiliation: Networking Research Center on Bioengineering Biomaterials and Nanomedicine (CIBER-BBN), Valencia, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Martínez-Bisbal
authors.forename: B
authors.initials: B
authors.lastname: Celda
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D002794:Choline / Q000737:chemistry; D003404:Creatinine / Q000737:chemistry; D005909:Glioblastoma / Q000473:pathology; D006801:Humans; D007294:Inositol / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009103:Multiple Sclerosis / Q000473:pathology; D009336:Necrosis; D049268:Positron-Emission Tomography / Q000379:methods; D011522:Protons
chemical_list: D011522:Protons; D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003404:Creatinine; D002794:Choline