Novel detection system for plant protein production of pharmaceuticals and impact on conformational diseases.
tate-of-the-art biochemistry methods in combination with an automated phenotyping method demonstrate the high potential of transgenic tobacco plants in producing properly-folded therapeutic proteins for the treatment of protein-misfolding diseases (e.g., Alzheimer's disease). This molecular farming approach led to highest protein production of hydroponically-grown tobacco compared to other growth substrates generally used in plant cultivation.
Nagel
K A
KA
Institute of Chemistry and Dynamics of the Geosphere ICG-3: Phytosphere, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany. k.nagel@fz-juelich.de
Kastenholz
B
B
Gilmer
F
F
Schurr
U
U
Walter
A
A
D000544:Alzheimer Disease / Q000517:prevention & control*; D018533:Biomass; D001709:Biotechnology / Q000379:methods; D018527:Hydroponics / Q000379:methods; D009566:Nitrates / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D010940:Plant Proteins / Q000378:metabolism* / Q000627:therapeutic use*; D018520:Plant Shoots / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D030821:Plants, Genetically Modified; D000644:Quaternary Ammonium Compounds / Q000378:metabolism; D013678:Technology, Pharmaceutical / Q000379:methods; D013997:Time Factors; D014026:Nicotiana / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*
D009566:Nitrates; D004364:Pharmaceutical Preparations; D010710:Phosphates; D010940:Plant Proteins; D000644:Quaternary Ammonium Compounds; D009584:Nitrogen