[Liver fibrosis - pathogenesis and novel therapeutic approaches].
Chronic liver injury, such as viral hepatitis, alcohol, metabolic syndrome or other toxic damages, leads to an inflammatory response including the infiltration and activation of immune cells and to the proliferation and transdifferentiation of mesenchymal cells within the liver, especially of hepatic stellate cells. These cells produce an excess of extracellular matrix proteins that are deposited in the liver. Hepatic fibrosis may progress to liver cirrhosis and liver failure. This review aims at summarizing the current view on the pathogenic sequence during fibrogenesis highlighting the essential role of cytokines and chemokines. Understanding the complex cellular interactions in liver fibrosis may help to develop novel antifibrotic therapies in the near future.
Tacke
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F
Medizinische Klinik III, Universitätsklinikum Aachen, Pauwelsstrasse 30, 52074 Aachen, Deutschland. frank.tacke@gmx.net
Weiskirchen
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R
D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000503:physiopathology*
D007166:Immunosuppressive Agents