Brief communication: mitochondrial haplotype C4c confirmed as a founding genome in the Americas.
Mitochondrial DNA analysis of 31 unrelated Shuswap speakers from a previously poorly sampled region of North America revealed two individuals with haplogroups rarely found in the Americas, C4c and C1d. Comparison of the complete genomes of the two individuals with others found in the literature confirms that C4c is a founding haplotype and gives insight into the evolution of the C1d haplotype. This study demonstrates the importance of collecting and analyzing data from Native North Americans when addressing hypotheses about the peopling of the Americas.
Malhi
Ripan S
RS
Department of Anthropology, Animal Biology and Institute for Genomic Biology, University of Illinois Urbana-Champaign, IL 61801, USA. malhi@uiuc.edu
Cybulski
Jerome S
JS
Tito
Raul Y
RY
Johnson
Jesse
J
Harry
Harold
H
Dan
Carrie
C
D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D004272:DNA, Mitochondrial / Q000235:genetics*; D018703:Founder Effect; D005784:Gene Amplification; D015894:Genome, Human; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008928:Mitochondria / Q000235:genetics*; D009154:Mutation; D009656:North America; D010802:Phylogeny; D012463:Saliva / Q000737:chemistry
D004272:DNA, Mitochondrial; D004247:DNA