Insights into resistance against lincosamide antibiotics.
Bacteria utilize multiple strategies to circumvent antibiotics, producing broad specificity exporters or enzymes that catalyze the modification of either antibiotics or their targets. A report in this issue of Structure provides the structural and catalytic mechanisms of LinB, an adenylyltransferase of E. faecium that confers resistance to the lincosamide antibiotic clindamycin.
Sundlov
Jesse A
JA
Department of Structural Biology, Hauptman-Woodward Medical Research Institute, State University of New York at Buffalo, Buffalo, NY, USA.
Gulick
Andrew M
AM
Department of Structural Biology, Hauptman-Woodward Medical Research Institute, State University of New York at Buffalo, Buffalo, NY, USA. Electronic address: gulick@hwi.buffalo.edu.
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002981:Clindamycin / Q000737:chemistry / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics*; D016984:Enterococcus faecium / Q000187:drug effects*; D008958:Models, Molecular
D000900:Anti-Bacterial Agents; D002981:Clindamycin