title: Could Helicobacter pylori play an important role in axonal type of Guillain-Barré syndrome pathogenesis?
abstract: In this case-control study, ELISA and Western blot with whole bacterial protein lysate were performed on serum and cerebrospinal fluid (CSF) of 15 controls and 15 patients. According to Griffin subtypes, 10 of our patients were in acute inflammatory demyelinating polyradiculoneuropathy (AIDP) group, 3 in acute motor axonal neuropathy (AMAN) group, and 2 in acute motor sensory axonal neuropathy (AMSAN) subtype. 86.6% of patients were positive for Helicobacter pylori (H. pylori) IgG. Serum anti-H. pylori IgG of patients and controls were significantly different. CSF anti-H. pylori IgG was significantly higher in patients than controls. In patients, the titer of anti-H. pylori IgG in serum was significantly higher than CSF, which may indicate extra-neural antibody synthesis. CSF IgG titer was higher in patients having axonal pattern. Western blot was positive in CSF of 13 patients and negative in all controls. There was a correlation between the number of antibody types against H. pylori particles and the titer of anti-H. pylori IgG in CSF and serum. Also, antibody against cytotoxin associated protein (CagA) was associated with primary axonal pattern. The association between the presence of anti-CagA and primary axonal pattern, is in favor of the relation between axonal neuropathy and H. pylori infection.
authors.affiliation: Iranian Center of Neurological Research, Neurology Department, Tehran University of Medical Sciences, Iran.
authors.forename: Mojdeh
authors.initials: M
authors.lastname: Ghabaee
authors.forename: Davod
authors.initials: D
authors.lastname: Ghanbarian
authors.forename: Gholamreza Nikbakht
authors.initials: GN
authors.lastname: Brujeni
authors.forename: Saeed
authors.initials: S
authors.lastname: Bokaei
authors.forename: Farideh
authors.initials: F
authors.lastname: Siavoshi
authors.forename: Shahriar
authors.initials: S
authors.lastname: Gharibzadeh
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid; D000942:Antigens, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid; D001369:Axons / Q000473:pathology*; D001426:Bacterial Proteins / Q000097:blood / Q000134:cerebrospinal fluid; D015153:Blotting, Western; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D020275:Guillain-Barre Syndrome / Q000209:etiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D016481:Helicobacter Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D010525:Peripheral Nerves / Q000473:pathology; D012307:Risk Factors
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D007074:Immunoglobulin G; C080866:cagA protein, Helicobacter pylori