Rocuronium and vecuronium do not affect mandibular bone marrow and masseter muscular blood flow in rabbits.
OBJECTIVE
The goal of this study was to investigate the effect of rocuronium and vecuronium continuous infusion on oral tissue blood flow in rabbits.


METHODS
We used 8 male Japan White rabbits. The infusion rates of rocuronium were 7, 14, and 28 microg kg(-1) min(-1) for 20 minutes, in this order. After rocuronium was discontinued and body movement confirmed, continuous infusion of vecuronium was started. The infusion rates of vecuronium were 1.6, 3.2, and 6.4 microg kg(-1) min(-1) for 20 minutes, in this order. Observed variables were systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rate, common carotid artery blood flow, tongue mucosal blood flow, oxygen partial pressure of the mandibular bone marrow, and oxygen partial pressure of the masseter muscle.


RESULTS
Heart rate in both groups tended to decrease depending on the infusion rate. Common carotid artery blood flow in the rocuronium group was increased depending on the infusion rate. Tongue mucosal blood flow in the vecuronium group was decreased depending on the infusion rate. There were no differences in diastolic blood pressure, mean arterial pressure, oxygen partial pressure of the mandibular bone marrow, and oxygen partial pressure of the masseter muscle between the 2 groups. Systolic blood pressure in both groups showed no major change.


CONCLUSIONS
Rocuronium and vecuronium did not change mandibular bone marrow and masseter muscular blood flows. Vecuronium decreased tongue mucosal blood flow depending on the infusion rate.
Terakawa
Yui
Y
Department of Dental Anesthesiology, Tokyo Dental College, Mihama-ku, Chiba, Japan. terakawayui@tdc.ac.jp
Ichinohe
Tatsuya
T
Kaneko
Yuzuru
Y
D000732:Androstanols / Q000494:pharmacology*; D000768:Anesthesia, General; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001853:Bone Marrow / Q000098:blood supply*; D006339:Heart Rate / Q000187:drug effects; D007262:Infusions, Intravenous; D008297:Male; D008334:Mandible / Q000098:blood supply*; D008406:Masseter Muscle / Q000098:blood supply*; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism; D010313:Partial Pressure; D011817:Rabbits; D000077123:Rocuronium; D014059:Tongue / Q000098:blood supply; D014673:Vecuronium Bromide / Q000494:pharmacology*
D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D014673:Vecuronium Bromide; D010100:Oxygen; D000077123:Rocuronium