Perioperative beta-blockers for vascular surgery patients.
Perioperative beta-blocker therapy has been a heavily investigated and controversial topic during the past decade. Prior national consensus statements that recommended the routine use of these medications in patients undergoing high-risk surgical procedures have been called into question because of the results of recent clinical trials that involved heterogeneous groups of surgical patients. This article reviews the evidence for perioperative beta-blocker usage as it pertains to patients undergoing vascular surgery procedures. The weight of evidence suggests that beta-blockers lower the perioperative risk of myocardial ischemia or infarction and cardiovascular death among patients with clinical risk factors undergoing major vascular surgery. However, there appears to be a concurrent risk of adverse events associated with these medications if patients are not monitored properly during the perioperative period. Perioperative beta-blockers should continue to occupy a prominent role in the therapeutic armamentarium for improving outcomes among high-risk patients undergoing major vascular surgery.
Brooke
Benjamin S
BS
Department of Surgery, Johns Hopkins Hospital, Baltimore, MD 21287, USA. bbrooke1@jhmi.edu
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D019317:Evidence-Based Medicine; D006801:Humans; D018579:Patient Selection; D019990:Perioperative Care; D017410:Practice Guidelines as Topic; D018570:Risk Assessment; D014656:Vascular Surgical Procedures / Q000009:adverse effects / Q000401:mortality
D000319:Adrenergic beta-Antagonists