title: Chronic impact of topiramate on acid-base balance and potassium in childhood.
abstract: Topiramate, which is commonly prescribed for seizure disorders and migraine prophylaxis, sometimes causes metabolic acidosis and hypokalemia. Since the effects of topiramate on acid-base balance and potassium levels have not been well explored in children, acid-base balance, anion gap and potassium were assessed in 24 patients (8 females and 16 males) aged between 4.6 and 19 years on topiramate for more than 12 months and in an age-matched control group. Plasma bicarbonate (21.7 versus 23.4 mmol/L; P<0.03), carbon dioxide pressure (39.7 versus 43.2mm Hg; P<0.05), and potassium (3.7 versus 4.0 mmol/L; P<0.03) were on the average lower and chloride (109 versus 107 mmol/L; P<0.03) higher in patients treated with topiramate than in controls. Blood pH, plasma sodium and the anion gap were similar in patients on topiramate and in controls. In patients on topiramate no significant correlation was observed between the dosage of this agent and plasma bicarbonate or potassium as well as between topiramate blood level and the mentioned electrolytes. In conclusion long-term topiramate treatment is associated with a mild, statistically significant tendency towards compensated normal anion gap metabolic acidosis and hypokalemia.
authors.affiliation: Department of Pediatrics, Bellinzona and Mendrisio, and University of Bern, Switzerland.
authors.forename: Eva A
authors.initials: EA
authors.lastname: Belotti
authors.forename: Ilaria
authors.initials: I
authors.lastname: Taddeo
authors.forename: Monica
authors.initials: M
authors.lastname: Ragazzi
authors.forename: Rosanna
authors.initials: R
authors.lastname: Pifferini
authors.forename: Giacomo D
authors.initials: GD
authors.lastname: Simonetti
authors.forename: Mario G
authors.initials: MG
authors.lastname: Bianchetti
authors.forename: Gian P
authors.initials: GP
authors.lastname: Ramelli
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000138:Acidosis / Q000139:chemically induced; D000293:Adolescent; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D001639:Bicarbonates / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002712:Chlorides / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004573:Electrolytes / Q000097:blood*; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced; D008297:Male; D011188:Potassium / Q000097:blood*; D000077236:Topiramate; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D001639:Bicarbonates; D002712:Chlorides; D004573:Electrolytes; D000077236:Topiramate; D005632:Fructose; D011188:Potassium