Effect of Coenzyme Q10 in mitigating oxidative DNA damage in Down syndrome patients, a double blind randomized controlled trial.
Down syndrome (DS) is a chromosomal abnormality (trisomy 21) associated with a complex phenotype. Oxidative stress is known to play a major role in this pathology both due to genetic and epigenetic factors, suggesting that oxidative imbalance contributes to the clinical manifestation of DS. In particular, the implications of oxidative DNA damage in Down syndrome has been linked with neurodegeneration. Here we report the results of a double blind controlled trial aimed at investigating the protective effect of Coenzyme Q(10) on DNA oxidation in this clinical setting using the single cell gel electrophoresis technique.
Tiano
L
L
Department of Biochemistry Biology and Genetics, Polytechnic University of Marche, Via Ranieri, 60100 Ancona, Italy. luca.tiano@unicam.it
Carnevali
P
P
Padella
L
L
Santoro
L
L
Principi
F
F
Brugè
F
F
Carle
F
F
Gesuita
R
R
Gabrielli
O
O
Littarru
G P
GP
D000328:Adult; D004249:DNA Damage / Q000187:drug effects*; D004311:Double-Blind Method; D004314:Down Syndrome / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*; D016896:Treatment Outcome; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D014451:Ubiquinone; C024989:coenzyme Q10