title: Emerging role of neuregulin as a modulator of muscle metabolism.
abstract: Neuregulin was described initially as a neurotrophic factor involved in the formation of the neuromuscular junction in skeletal muscle. However, in recent years, neuregulin has been reported to be a myokine that exerts relevant effects on myogenesis and the regulation of muscle metabolism. In this new context, the rapid and chronic metabolic effects of neuregulin appear to be related to muscle contraction. Indeed, the effects of neuregulin resemble those of exercise, which are accompanied by an improvement in insulin sensitivity. In this review, we challenge the classical role assigned to neuregulin in muscle and propound the emerging concept of its involvement in the regulation of energetic metabolism and insulin responsiveness.
authors.affiliation: Dept. of Biochemistry and Molecular Biology, Univ. of Barcelona, Spain. aguma@ub.edu
authors.forename: Anna
authors.initials: A
authors.lastname: Gumà
authors.forename: Vicente
authors.initials: V
authors.lastname: Martínez-Redondo
authors.forename: Iliana
authors.initials: I
authors.lastname: López-Soldado
authors.forename: Carles
authors.initials: C
authors.lastname: Cantó
authors.forename: Antonio
authors.initials: A
authors.lastname: Zorzano
mesh_terms: D000818:Animals; D015444:Exercise / Q000502:physiology; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009119:Muscle Contraction / Q000502:physiology; D009132:Muscles / Q000378:metabolism / Q000502:physiology*; D020880:Neuregulins / Q000378:metabolism / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology
chemical_list: D020880:Neuregulins; D011956:Receptors, Cell Surface