N-Heterocyclic carbene-catalyzed intramolecular aldehyde-nitrile cross coupling: an easy access to 3- aminochromones.
An immense effort has been made to develop an efficient strategy for the carbon-carbon bond formation between aldehyde and nitrile intramolecularly using an N-heterocyclic carbene catalyst to derive 3-aminochromone derivatives in good to excellent yields (80-95%).
Vedachalam
Seenuvasan
S
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.
Zeng
Jing
J
Gorityala
Bala Kishan
BK
Antonio
Meraldo
M
Liu
Xue-Wei
XW
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D002867:Chromones / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*
D000447:Aldehydes; D002867:Chromones; D006571:Heterocyclic Compounds; D009570:Nitriles; C030011:carbene; D008697:Methane