The insulin-like growth factor-1 axis and its potential as a therapeutic target in central nervous system (CNS) disorders.
The insulin-like growth factor-1 (IGF-1) is a pleiotropic factor. Many studies have revealed its importance in the development and maintenance of the central nervous system (CNS). This review will discuss the IGF-1 axis, from the factor itself to the signalling pathways it activates, and its tight regulation. Particular focus will be brought on potential therapeutic targets of the IGF-1 axis in CNS disorders, including brain tumours and neurodegenerative diseases affecting neurons and oligodendrocytes.
Bibollet-Bahena
Olivia
O
Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir-William-Osler, Montreal, Quebec, Canada.
Cui
Qiao-Ling
QL
Almazan
Guillermina
G
D000375:Aging / Q000502:physiology; D000818:Animals; D001321:Autistic Disorder / Q000276:immunology; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D002490:Central Nervous System / Q000503:physiopathology*; D002493:Central Nervous System Diseases / Q000150:complications / Q000235:genetics / Q000473:pathology; D003071:Cognition / Q000502:physiology; D003670:Deer; D015316:Genetic Therapy; D018392:Genomic Imprinting; D019382:Human Growth Hormone / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009416:Nerve Regeneration / Q000276:immunology* / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D009836:Oligodendroglia; D015398:Signal Transduction
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I