Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies.
BACKGROUND
Chikungunya fever is an emerging arboviral disease characterized by an algo-eruptive syndrome, inflammatory polyarthralgias, or tenosynovitis that can last for months to years. Up to now, the pathophysiology of the chronic stage is poorly understood.


METHODS
We report the first case of CHIKV infection with chronic associated rheumatism in a patient who developed progressive erosive arthritis with expression of inflammatory mediators and persistence of specific IgM antibodies over 24 months following infection.


CONCLUSIONS
Understanding the specific features of chikungunya virus as well as how the virus interacts with its host are essential for the prevention, treatment or cure of chikungunya disease.
Malvy
Denis
D
Travel Clinics and Tropical Disease Unit, Department of Internal Medicine, Infectious Diseases and Tropical Medicine, University Hospital Center, Bordeaux, F-33075 France. denis.malvy@chu-bordeaux.fr
Ezzedine
Khaled
K
Mamani-Matsuda
Maria
M
Autran
Brigitte
B
Tolou
Hugues
H
Receveur
Marie-Catherine
MC
Pistone
Thierry
T
Rambert
Jérome
J
Moynet
Daniel
D
Mossalayi
Djavad
D
D018354:Alphavirus Infections / Q000097:blood / Q000150:complications* / Q000276:immunology; D000914:Antibodies, Viral / Q000097:blood*; D001170:Arthritis, Infectious / Q000097:blood / Q000209:etiology* / Q000276:immunology; D002646:Chikungunya virus / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged
D000914:Antibodies, Viral; D007075:Immunoglobulin M