[Vitamin D, cardiovascular disease and mortality in patients with kidney disease].
Chronic kidney disease is associated with an increased risk of cardiovascular disease. Vitamin D deficiency is common in patients with chronic kidney disease. In epidemiological studies, vitamin D deficiency and absence of treatment with vitamin D is associated with increased cardiovascular mortality. Several possible mechanisms may explain how vitamin D can influence the development of cardiovascular disease. Clinical intervention studies are needed to clarify whether treatment with vitamin D decreases the risk of cardiovascular disease in chronic kidney disease.
Hansen
Ditte
D
Medicinsk Afdeling, Roskilde Sygehus, DK-4000, Roskilde, Denmark. dhn@regionsjaelland.dk
Brandi
Lisbet
L
Rasmussen
Knud
K
D000818:Animals; D002114:Calcinosis / Q000209:etiology / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000209:etiology / Q000401:mortality* / Q000517:prevention & control; D006333:Heart Failure / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000378:metabolism; D006435:Renal Dialysis / Q000009:adverse effects; D012307:Risk Factors; D014652:Vascular Diseases / Q000209:etiology / Q000517:prevention & control; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism; D014808:Vitamin D Deficiency / Q000150:complications* / Q000188:drug therapy
D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D