Electron transfer photoredox catalysis: intramolecular radical addition to indoles and pyrroles.
The utilization of the photoredox catalyst, tris(2,2'-bipyridyl)ruthenium dichloride, and a household light bulb to effect radical cyclizations onto indoles and pyrroles at room temperature is reported. A reactive free radical intermediate is generated via the reduction of an activated C-Br bond by the single electron reductant, Ru(I), generated in a visible light induced photocatalytic cycle. This system represents an expansion of the application of photoredox catalysis in conventional free radical processes.
Tucker
Joseph W
JW
Department of Chemistry, Boston University, Boston, Massachusetts 02215, USA.
Narayanam
Jagan M R
JM
Krabbe
Scott W
SW
Stephenson
Corey R J
CR