[Biomarkers in the modern medical and biologic practice].
The lecture deals with biomarkers, a newly introduced direction in biomedical research. The following terms, definitions, and characteristics were proposed to describe biomarkers: diagnostic tools, clinical endpoints and surrogate endpoints. Examples of predictors for cardiovascular diseases, acute-phase of inflammation and malignant tumors are represented. The special attention is given to the characteristic of the widespread biomarkers: homocysteine, transthyretin and C-reactive protein. Modern methods of identification, qualitative and quantitative determination of biomarkers are considered: mass spectrometric methods, immunoassay. The relationships between the latest achievements in the field of genomics, proteomics, bioinformatics and biomarker's investigations are established. The perspectives of biomarkers are discussed.
Miroshnichenko
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II
Ptitsyna
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D015415:Biomarkers / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000175:diagnosis; D023281:Genomics; D006801:Humans; D007249:Inflammation / Q000175:diagnosis; D008991:Monitoring, Physiologic / Q000379:methods; D009369:Neoplasms / Q000175:diagnosis; D011379:Prognosis; D012016:Reference Values; D018570:Risk Assessment / Q000379:methods
D015415:Biomarkers