title: Novel swine-origin (S-OIV) H1N1 influenza A pneumonia in a lung transplant patient: a case report and review of the literature on performance characteristics of rapid screening tests for the S-OIV.
abstract: Rapid screening tests are insensitive for detecting the novel swine-origin influenza A (H1N1) virus (S-OIV), and false negatives can delay the diagnosis and initiation of appropriate antiviral therapy. The case of a 26-year-old double lung transplant recipient presenting with fever, bilateral pulmonary infiltrates, and a negative influenza direct immunofluorescent antibody on bronchoalveolar lavage is presented. A diagnosis was made, and antiviral therapy was started 10 days after the initial bronchoalveolar lavage on receipt of a positive culture for S-OIV. The published literature on the performance characteristics of rapid screening tests for S-OIV is reviewed in this clinical context.
authors.affiliation: Critical Care and Sleep Medicine, Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430-9410, USA. rishi.raj@ttuhsc.edu
authors.forename: Rishi
authors.initials: R
authors.lastname: Raj
authors.forename: Mario
authors.initials: M
authors.lastname: Cerdan
authors.forename: Andresfelipe
authors.initials: A
authors.lastname: Yepeshurtado
authors.forename: Robert
authors.initials: R
authors.lastname: Kimbrough
authors.forename: Kenneth
authors.initials: K
authors.lastname: Nugent
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000821:virology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology* / Q000821:virology; D016040:Lung Transplantation / Q000009:adverse effects* / Q000276:immunology; D009894:Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000821:virology; D053139:Oseltamivir / Q000627:therapeutic use; D011024:Pneumonia, Viral / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology* / Q000821:virology; D014773:Virology / Q000379:methods*
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir