title: Pulmonary Embolism Severity Index and troponin testing for the selection of low-risk patients with acute symptomatic pulmonary embolism.
abstract: BACKGROUND
  The combination of the Pulmonary Embolism Severity Index (PESI) and troponin testing could help physicians identify appropriate patients with acute pulmonary embolism (PE) for early hospital discharge.
  
  
  METHODS
  This prospective cohort study included a total of 567 patients from a single center registry with objectively confirmed acute symptomatic PE. On the basis of the PESI, each patient was classified into one of five classes (I-V). At the time of hospital admission, patients had troponin I (cTnI) levels measured. The endpoint of the study was all-cause mortality within 30 days after diagnosis. We calculated the mortality rates in four patient groups: group 1, PESI class I-II plus cTnI < 0.1 ng mL(-1); group 2, PESI classes III-V plus cTnI < 0.1 ng mL(-1); group 3, PESI classes I-II plus cTnI > or = 0.1 ng mL(-1); and group 4, PESI classes III-V plus cTnI > or = 0.1 ng mL(-1).
  
  
  RESULTS
  The study cohort had a 30-day mortality of 10% [95% confidence interval (CI), 7.6-12.5%]. Mortality rates in the four groups were 1.3%, 14.2%, 0% and 15.4%, respectively. Compared with non-elevated cTnl, the low-risk PESI had a higher negative predictive value (NPV) (98.9% vs. 90.8%) and negative likelihood ratio (NLR) (0.1 vs. 0.9) for predicting mortality. The addition of non-elevated cTnI to low-risk PESI did not improve the NPV or the NLR compared with either test alone.
  
  
  CONCLUSIONS
  Compared with cTnl testing, PESI classification more accurately identified patients with PE who are at low risk of all-cause death within 30 days of presentation.
authors.affiliation: F. Edward Hebert School of Medicine, Uniformed Services University, Bethesda, MD, USA.
authors.forename: L
authors.initials: L
authors.lastname: Moores
authors.forename: D
authors.initials: D
authors.lastname: Aujesky
authors.forename: D
authors.initials: D
authors.lastname: Jiménez
authors.forename: G
authors.initials: G
authors.lastname: Díaz
authors.forename: V
authors.initials: V
authors.lastname: Gómez
authors.forename: D
authors.initials: D
authors.lastname: Martí
authors.forename: S
authors.initials: S
authors.lastname: Briongos
authors.forename: R
authors.initials: R
authors.lastname: Yusen
mesh_terms: D000208:Acute Disease; D000368:Aged; D000553:Ambulatory Care; D015415:Biomarkers / Q000097:blood; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D016013:Likelihood Functions; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010351:Patient Discharge; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000097:blood / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I