title: Follicular-fluid anti-Mullerian hormone concentrations are predictive of assisted reproduction outcome in PCOS patients.
abstract: Serum anti-Mullerian hormone (AMH) concentrations constitute a sensitive marker for ovarian ageing. In addition, concentrations of AMH in the follicular fluid constitute a useful marker of embryo implantation in assisted reproduction cycles. The present study measured serum and follicular-fluid AMH concentrations on the day of oocyte retrieval. These data showed that clinical pregnancy rates (25.0, 34.1 and 42.1%, respectively, P < 0.001), embryo implantation rates (24.3, 35.0 and 44.4%, respectively, P < 0.001) and fertilization rates (59.2, 70.9 and 79.5%, respectively, P < 0.001) were markedly different among the low, moderate and high follicular-fluid AMH groups but not among the different serum AMH concentration groups. Follicular-fluid AMH concentrations were negatively correlated with follicular-fluid oestradiol concentrations. The results of this study suggest that follicular-fluid AMH concentration on the day of oocyte retrieval would appear to better reflect the reproductive outcome in PCOS patients undergoing assisted reproduction.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Ufuk University, Ankara, Turkey.
authors.forename: Recai
authors.initials: R
authors.lastname: Pabuccu
authors.forename: Cemil
authors.initials: C
authors.lastname: Kaya
authors.forename: Gamze Sinem
authors.initials: GS
authors.lastname: Cağlar
authors.forename: Efser
authors.initials: E
authors.lastname: Oztas
authors.forename: Hakan
authors.initials: H
authors.lastname: Satiroglu
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D010064:Embryo Implantation; D005260:Female; D005306:Fertilization; D015571:Follicular Fluid / Q000378:metabolism*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D054315:Oocyte Retrieval; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011247:Pregnancy; D011256:Pregnancy Outcome; D027724:Reproductive Techniques, Assisted
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone