Drug-induced myopathies.
The most common drugs currently in use that may cause myopathies were reviewed using the Medline database (U.S. National Library of Medicine, Bethesda, Maryland). Our review included results from epidemiologic and database surveys, clinical trials, and case reports. The clinical spectrum is wide, and presentations range from asymptomatic elevations in serum creatine phosphokinase levels to severe life-threatening rhabdomyolysis. Management of suspected drug-induced myopathy should include immediate discontinuation of the offending agent, as well as supportive care when needed. Earlier diagnosis and drug discontinuation raises the likelihood of resolution and recovery.
Mor
Adam
A
Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA. adam.mor@nyumc.org
Mitnick
Hal J
HJ
Pillinger
Michael H
MH
Wortmann
Robert L
RL
D016903:Drug Monitoring; D064420:Drug-Related Side Effects and Adverse Reactions; D042241:Early Diagnosis; D019317:Evidence-Based Medicine; D006801:Humans; D009135:Muscular Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D018570:Risk Assessment; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000150:complications*