Increasing the hydrophobicity and electrospray response of glycans through derivatization with novel cationic hydrazides.
Novel tags are used to increase the hydrophobicity of glycans and impart a permanent charge yielding as great as a approximately 5-fold increase in electrospray response from both a standard and complex mixture.
Bereman
Michael S
MS
W.M. Keck FTICR Mass Spectrometry Laboratory, Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA.
Comins
Daniel L
DL
Muddiman
David C
DC