Norepinephrine content in the hypothalamus and medulla oblongata of ISIAH rats is regulated by several genetic loci.
Five genetic loci regulating epinephrine content in rat hypothalamus and two loci in the medulla oblongata were identified using polymorphic microsatellite DNA markers. Allele polymorphism of these loci determines the differences between norepinephrine levels in brain compartments of hypertensive ISIAH and normotensive WAG rats. The interactions between the detected epinephrine-regulating loci are additive.
Redina
O E
OE
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. oredina@bionet.nsc.ru
Smolenskaya
S E
SE
Jacobson
G S
GS
Markel
A L
AL
D000818:Animals; D005786:Gene Expression Regulation / Q000235:genetics; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D007031:Hypothalamus / Q000378:metabolism*; D008526:Medulla Oblongata / Q000378:metabolism*; D018895:Microsatellite Repeats / Q000235:genetics*; D009638:Norepinephrine / Q000235:genetics* / Q000378:metabolism*; D011110:Polymorphism, Genetic / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000235:genetics* / Q000502:physiology
D009638:Norepinephrine