Differential tissue distribution of sesaminol triglucoside and its metabolites in rats fed with lignan glycosides from sesame meal with or without nano/submicrosizing.
Lignan glycosides are important functional compounds in sesame meal. In the present study, we investigated whether the tissue distribution of nano/submicrosized lignan glycosides from sesame meal (N-LGSM) differs from lignan glycosides from sesame meal (LGSM). LGSM was nano/submicrosized with 0.3 mm zirconia beads as the milling media. The average particle size of the 4% LGSM aqueous suspension reduced rapidly from approximately 2 microm to 200 nm after media milling at an agitation speed of 3600 rpm for 30 min. We examined the tissue distribution of sesaminol triglucoside (ST), the main component in LGSM, in Sprague-Dawley (SD) rats. The concentrations of ST were determined in various tissues and plasma within a 24 h period after oral administration of N-LGSM and LGSM (800 mg/kg of body weight). The results showed that higher concentrations of ST and its metabolites (sesaminol, sesaminol sulfate, and sesaminol glucuronide) were found in N-LGSM compared to those in LGSM in most tissues, especially liver and small intestine. Sesaminol glucuronide was the main metabolite in rats. After 3 h of oral administration, around 70% higher concentration of sesaminol glucuronide was found in N-LGSM compared to that in LGSM. This study clearly showed that LGSM is more bioavailable after nano/submicrosizing.
Liao
Chia-Ding
CD
Graduate Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.
Hung
Wei-Lun
WL
Lu
Wen-Chien
WC
Jan
Kuo-Ching
KC
Shih
Daniel Yang-Chih
DY
Yeh
An-I
AI
Ho
Chi-Tang
CT
Hwang
Lucy Sun
LS
D000818:Animals; D005511:Food Handling; D005960:Glucosides / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D006027:Glycosides / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D017705:Lignans / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D010316:Particle Size; D028321:Plant Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D031685:Sesamum / Q000737:chemistry* / Q000378:metabolism; D014018:Tissue Distribution
D005960:Glucosides; D006027:Glycosides; D017705:Lignans; D028321:Plant Preparations; C518861:sesaminol triglucoside