Effect of second and third generation oral contraceptives on C-reactive protein, lipids and apolipoproteins in young, non-obese, non-smoking apparently healthy women.
OBJECTIVE
Third generation oral contraceptives (OC) may increase the risk of cardiovascular events in healthy young women.


METHODS
We assessed the effect of second and third generation OC on CRP, lipids and apolipoproteins in 128 women.


RESULTS
CRP was significantly higher in third generation contraceptive users. The main determinant of CRP in OC users was triglycerides.


CONCLUSIONS
Young women using oral contraceptives, especially third generation formulas, might not be free of cardiovascular risk having increased CRP concentration.
Krintus
Magdalena
M
Department of Laboratory Medicine, Collegium Medicum, Nicolaus Copernicus University, ul. M.Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland. krintus@wp.pl
Sypniewska
Grazyna
G
Kuligowska-Prusinska
Magdalena
M
D000328:Adult; D000367:Age Factors; D001053:Apolipoproteins / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D016022:Case-Control Studies; D003276:Contraceptives, Oral / Q000494:pharmacology*; D005260:Female; D006262:Health; D006801:Humans; D056865:Ideal Body Weight / Q000187:drug effects / Q000502:physiology; D008055:Lipids / Q000097:blood*; D009765:Obesity / Q000097:blood; D012307:Risk Factors; D012907:Smoking / Q000097:blood
D001053:Apolipoproteins; D003276:Contraceptives, Oral; D008055:Lipids; D002097:C-Reactive Protein