title: The sequential building of chiral macrocyclic bis-beta-lactams by double staudinger-Cu-catalyzed azide-alkyne cycloadditions.
abstract: A novel approach for the synthesis of macrocyclic bis-beta-lactams based on the Cu-catalyzed alkyne-azide cycloaddition (CuAAC) is reported. The procedure is general and allows access to a full range of diastereomerically or enantiomerically pure macrocyclic cavities in good yields. The incorporation of chiral oxazolidinone fragments at C3 in the beta-lactam rings allows the total enantiocontrol of the process.
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad Complutense, 28040 Madrid, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Pellico
authors.forename: Mar
authors.initials: M
authors.lastname: Gómez-Gallego
authors.forename: Pedro
authors.initials: P
authors.lastname: Ramírez-López
authors.forename: María José
authors.initials: MJ
authors.lastname: Mancheño
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Sierra
authors.forename: M Rosario
authors.initials: MR
authors.lastname: Torres