title: Normal growth hormone secretion in overweight young adults with Down syndrome.
abstract: Down syndrome (DS) is associated with short stature and obesity. Adults with DS have several features in common with growth hormone (GH) deficient adult subjects. The aim of this study was to investigate GH secretion in young adults with DS and its relation to body composition as well as glucose and lipid metabolism. Ten young adults with DS (aged 24-32 years; 5 F) and ten controls matched for age and sex were examined regarding spontaneous nocturnal GH secretion and body composition. Stable isotope tracers were used to study glucose and lipid metabolism in the DS subjects. There was no difference in secretion of GH between the DS subjects and controls. The DS subjects had a higher BMI, fat mass proportion and HOMA (homeostasis model assessment) index compared with the controls. The rates of production of glucose and glycerol (reflecting lipolysis) in the DS subjects were increased (15.5+/-5.07 and 3.5+/-1.68 micromol/kg/min, respectively). The DS subjects showed normal GH secretion despite increased BMI and fat mass. The increased HOMA index and high rate of glucose production indicate peripheral and hepatic insulin resistance in adult DS subjects.
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. asa.myrelid@kbh.uu.se
authors.forename: A
authors.initials: A
authors.lastname: Myrelid
authors.forename: P
authors.initials: P
authors.lastname: Frisk
authors.forename: M
authors.initials: M
authors.lastname: Stridsberg
authors.forename: G
authors.initials: G
authors.lastname: Annerén
authors.forename: J
authors.initials: J
authors.lastname: Gustafsson
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D001827:Body Height; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology; D016022:Case-Control Studies; D002940:Circadian Rhythm / Q000502:physiology; D004314:Down Syndrome / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D005260:Female; D019382:Human Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D009929:Organ Size; D050177:Overweight / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin; D019382:Human Growth Hormone