[Proteolytic activity of placenta with EPH-gestosis].
Essential edema-proteinuria-hypertension (EPH) gestosis still represents an important obstetrical problem. We have investigated the activity of carboxypeptidase H (CPH), phenylmethylsulfonyl fluoride inhibited carboxypeptidase (PMSF-CP), carboxypeptidase M (CPM) and angiotensin-converting enzyme (ACE), the main carboxypeptidases in human placenta under normal conditions and mild EPH-gestosis. Gestosis was accompanied by the decrease in activity of the enzymes involved into metabolism of regulatory peptides (ACE, CPH, PMSF-CP, CPM) compared with their activity in placenta under physiological pregnancy. Correlation analysis revealed positive correlation between placental CPH and CPM (r = 0.2735*) in EPH-gestosis. These findings suggest involvement of placental proteases into formation of compensatory-adaptive reactions in the fetoplacental complex at EPH-gestosis; the data obtained may be also employed for the development of methods of prophylaxis and corrections of metabolic impairments in pathology of pregnancy.
Petrushova
O P
OP
Gengin
M T
MT
Smetanin
V A
VA
Kuznetsova
A V
AV
D000328:Adult; D005260:Female; D006801:Humans; D010447:Peptide Hydrolases / Q000378:metabolism*; D010920:Placenta / Q000201:enzymology* / Q000473:pathology; D011225:Pre-Eclampsia / Q000201:enzymology* / Q000473:pathology; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000378:metabolism*
D011257:Pregnancy Proteins; D010447:Peptide Hydrolases