Predicting the advent of ascites and other complications in primary biliary cirrhosis: a staged model approach.
BACKGROUND
Current survival models for primary biliary cirrhosis have limited precision for medium and long-term survival. Aim To describe a prognostic model for the advent of complications in primary biliary cirrhosis as the first approach to a staged prognostic model.


METHODS
From an established database of 289 consecutive primary biliary cirrhosis patients referred to Royal Free Hospital over 12 years (mean follow-up of 4.1 years), baseline characteristics at referral were evaluated by Cox-proportional hazards regression modelling.


RESULTS
The following complications occurred de novo: 85 ascites/peripheral oedema, 40 oesophagogastric varices, 63 encephalopathy, 29 spontaneous bacterial peritonitis and/or septicaemia, 59 symptomatic urinary tract infections. Age, albumin, log(10)(bilirubin), presence of ascites at referral, variceal bleeding within 6 weeks before referral, detection of oesophagogastric varices at or before referral were significant at multivariate analysis with different combinations and coefficients for each complication. The model for predicting ascites and/or peripheral oedema best fitted the observed data (ROC = 0.7682, S.E. = 0.0385).


CONCLUSIONS
The known prognostic factors in primary biliary cirrhosis also model the advent of complications. In view of the prognostic importance of ascites and its more robust statistical model, ascites and/or peripheral oedema could represent, following validation, the most suitable staged model in primary biliary cirrhosis to improve precision in survival modelling.
Chan
C-W
CW
The Royal Free Sheila Sherlock Liver Centre and Division of Surgery, Royal Free Hospital, Hampstead, London, UK.
Tsochatzis
E A
EA
Carpenter
J R
JR
Rigamonti
C
C
Gunsar
F
F
Burroughs
A K
AK
D000328:Adult; D000368:Aged; D001201:Ascites / Q000209:etiology / Q000401:mortality*; D015331:Cohort Studies; D018450:Disease Progression; D004487:Edema / Q000209:etiology / Q000401:mortality*; D004932:Esophageal and Gastric Varices / Q000209:etiology / Q000401:mortality; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000401:mortality*; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D015233:Models, Statistical; D010538:Peritonitis / Q000209:etiology / Q000401:mortality; D011379:Prognosis; D012307:Risk Factors; D018805:Sepsis / Q000209:etiology / Q000401:mortality; D016019:Survival Analysis; D014552:Urinary Tract Infections / Q000209:etiology / Q000401:mortality