MPTP lesion causes neuroinflammation and deficits in object recognition in Wistar rats.
Animal models of Parkinson's disease with dementia would greatly facilitate research into the underlying causes of this disorder. Here, we showed that bilateral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the substantia nigra pars compacta (SNc) of Wistar rats caused degeneration of nigrostriatal dopaminergic neurons, cell loss in the hippocampal CA1 area, as well as microglial activation and increase of interleukin-2 levels in several brain regions. In addition, increase of anxiety-like behavior and impairment of object recognition were observed in the MPTP-lesioned rats. These findings suggest that neuroinflammation may contribute to MPTP-induced neurodegeneration and behavioral deficits, which is suggested as an animal model of Parkinson's disease dementia.
Wang
Wen-Fu
WF
Department of Neurology, Chang-Hua Christian Hospital, Taiwan, ROC.
Wu
Shey-Lin
SL
Liou
Ying-Ming
YM
Wang
An-Li
AL
Pawlak
Cornelius Rainer
CR
Ho
Ying-Jui
YJ
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology; D004298:Dopamine / Q000378:metabolism; D004660:Encephalitis / Q000139:chemically induced* / Q000473:pathology; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D007376:Interleukin-2 / Q000378:metabolism; D008297:Male; D009410:Nerve Degeneration / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D021641:Recognition, Psychology / Q000187:drug effects*; D013037:Spatial Behavior / Q000187:drug effects; D013997:Time Factors; D014741:Video Recording
D007376:Interleukin-2; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine