Reproductive endocrinology of adolescent polycystic ovary syndrome.
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among reproductive-aged women, and it typically presents during adolescence. The objective of this review is to describe the clinical manifestations of PCOS in adolescent girls and the underlying basis for the altered reproductive physiology. Recognising adolescents at risk for PCOS and taking the appropriate steps to reduce circulating androgen levels is critical in reducing the clinical symptomatology of this disorder, and the development of adulthood infertility, diabetes, and metabolic syndrome in patients with PCOS.
Shayya
R
R
Division of Reproductive Endocrinology, Department of Reproductive Medicine, University of California, San Diego, CA, USA.
Chang
R J
RJ
D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000378:metabolism; D000858:Anovulation / Q000378:metabolism; D054304:Anti-Mullerian Hormone / Q000378:metabolism; D002648:Child; D003687:Dehydroepiandrosterone / Q000378:metabolism; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D006801:Humans; D017588:Hyperandrogenism / Q000378:metabolism* / Q000517:prevention & control; D006946:Hyperinsulinism / Q000378:metabolism; D007986:Luteinizing Hormone / Q000187:drug effects / Q000378:metabolism; D008597:Menstrual Cycle / Q000378:metabolism; D008599:Menstruation Disturbances / Q000378:metabolism / Q000503:physiopathology*; D009765:Obesity / Q000378:metabolism; D010053:Ovary / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology*; D011374:Progesterone / Q000494:pharmacology / Q000502:physiology; D011627:Puberty / Q000502:physiology*; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D014463:Ultrasonography
D000728:Androgens; D012738:Sex Hormone-Binding Globulin; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D003687:Dehydroepiandrosterone; D011374:Progesterone; D054304:Anti-Mullerian Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone