title: Molluscicidal activity of Hammada scoparia (Pomel) Iljin leaf extracts and the principal alkaloids isolated from them against Galba truncatula.
abstract: The molluscicidal activity of Hammada scoparia leaf extracts and the principal alkaloids isolated from them (carnegine and N-methylisosalsoline) were tested against the mollusc gastropod, Galba truncatula, the intermediate host of Fasciola hepatica in Tunisia. The results indicated that the molluscicidal activity was correlated with the presence of alkaloids. A significant molluscicidal value, according to the World Health Organization, was found with the methanol extract (LC50 = 28.93 ppm). Further fractionation of the methanolic extract led to the isolation of two principal alkaloids: carnegine and N-methylisosalsoline. These alkaloids are isoquinolines that have not previously been characterised for their molluscicidal activity. The N-methylisosalsoline possesses the highest molluscicidal activity (LC50 = 0.47 microM against G. truncatula).
authors.affiliation: Laboratory of Natural Substances Chemistry, Faculty of Science, Sfax, Tunisia.
authors.forename: R
authors.initials: R
authors.lastname: Mezghani-Jarraya
authors.forename: H
authors.initials: H
authors.lastname: Hammami
authors.forename: A
authors.initials: A
authors.lastname: Ayadi
authors.forename: M
authors.initials: M
authors.lastname: Damak
mesh_terms: D000470:Alkaloids / Q000145:classification / Q000302:isolation & purification; D000818:Animals; D007546:Isoquinolines / Q000145:classification / Q000302:isolation & purification; D008975:Molluscacides / Q000737:chemistry; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012908:Snails / Q000187:drug effects*
chemical_list: D000470:Alkaloids; D007546:Isoquinolines; D008975:Molluscacides; D010936:Plant Extracts