title: Dimeric guaianolides and sesquiterpenoids from Artemisia anomala.
abstract: A new dimeric guaianolide (8) and a new glaucolide (3), a seco-guaiaretic acid (4), two guaianolides (6 and 7), and five known sesquiterpene lactones (1, 2, 5, 9, and 10) were isolated from the aerial part of Artemisia anomala. Their structures were determined on the basis of chemical and spectroscopic analysis. In addition, their cytotoxic activities against five human cancer cell lines and anti-COX-2 effects in vitro were evaluated.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wen
authors.forename: Haiming
authors.initials: H
authors.lastname: Shi
authors.forename: Zhengren
authors.initials: Z
authors.lastname: Xu
authors.forename: Haitao
authors.initials: H
authors.lastname: Chang
authors.forename: Cunqin
authors.initials: C
authors.lastname: Jia
authors.forename: Ke
authors.initials: K
authors.lastname: Zan
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
authors.forename: Pengfei
authors.initials: P
authors.lastname: Tu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019306:Artemisia / Q000737:chemistry*; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D052246:Cyclooxygenase 2 Inhibitors; D004365:Drugs, Chinese Herbal; D007783:Lactones; D012717:Sesquiterpenes