title: ATP transport in saccular cerebral aneurysms at arterial bends.
abstract: ATP acts as an extracellular signaling molecule in purinergic signaling that regulates vascular tone. ATP binds purinergic P2 nucleotide receptors on endothelial cells. Understanding the mass transport of ATP to endothelial cells by blood flow is thus important to predict functional changes in aneurysmal walls. While some clinical observations indicate a difference of wall pathology between ruptured and unruptured aneurysms, no study has focused on the mass transport in aneurysms. We investigated the characteristics of ATP concentration at aneurysmal wall using a numerical model of ATP transport in aneurysms formed at arterial bends. The magnitude of ATP concentration at the aneurysmal wall was significantly smaller than that at the arterial wall. In particular, significantly low concentration was predicted at the proximal side of the aneurysmal sac. A strong correlation was revealed between the inflow flux at the aneurysmal neck and the resultant concentration at the aneurysmal wall.
authors.affiliation: Department of Bioengineering and Robotics, Tohoku University, 6-6-01 Aramaki Aza Aoba, Aoba-ku, Sendai-shi, Miyagi, 980-8579, Japan. yimai@pfsl.mech.tohoku.ac.jp
authors.forename: Yohsuke
authors.initials: Y
authors.lastname: Imai
authors.forename: Kodai
authors.initials: K
authors.lastname: Sato
authors.forename: Takuji
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Andrew
authors.initials: A
authors.lastname: Comerford
authors.forename: Tim
authors.initials: T
authors.lastname: David
authors.forename: Takami
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D001693:Biological Transport, Active; D002536:Cerebral Arteries / Q000503:physiopathology*; D003198:Computer Simulation; D006801:Humans; D002532:Intracranial Aneurysm / Q000503:physiopathology*; D008955:Models, Cardiovascular
chemical_list: D000255:Adenosine Triphosphate