A novel ruthenium(III) complex with a tridentate dianionic P,O,O-ligand showing high cytotoxic activity.
Tris(o-anisyl)phosphane was reacted with ruthenium(III) chloride forming a novel Ru(III) complex of formula [Ru(PAn(3))(P(An)(phenolate)(2))Cl] containing a tridentate dianionic P,O,O-ligand and a bidentate neutral P,O ligand. The tridentate ligand was formed by elimination of two methyl groups from the starting ligand in the reaction with the ruthenium salt. The molecular structure was determined by single crystal X-ray diffraction analysis. The compound shows a high cytotoxic activity in ovarian cancer cell lines comparable with cisplatin and overcoming cisplatin-resistance.
van Rijn
Jimmy A
JA
Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, 2300 Leiden, The Netherlands.
Marqués-Gallego
Patricia
P
Reedijk
Jan
J
Lutz
Martin
M
Spek
Anthony L
AL
Bouwman
Elisabeth
E
D000838:Anions / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry / Q000633:toxicity*; D018360:Crystallography, X-Ray; D006801:Humans; D008024:Ligands; D008968:Molecular Conformation; D010100:Oxygen / Q000737:chemistry*; D010758:Phosphorus / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
D000838:Anions; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D010758:Phosphorus; D012428:Ruthenium; D010100:Oxygen