title: Should bladder cuff excision remain the standard of care at nephroureterectomy in patients with urothelial carcinoma of the renal pelvis? A population-based study.
abstract: BACKGROUND
  A large, multi-institutional, tertiary care center study suggested no benefit from bladder cuff excision (BCE) at nephroureterectomy in patients with upper tract urothelial carcinoma (UC).
  
  
  OBJECTIVE
  We tested and quantified the prognostic impact of BCE at nephroureterectomy on cancer-specific mortality (CSM) in a large population-based cohort of patients with UC of the renal pelvis.
  
  
  METHODS
  A cohort of 4210 patients with UC of the renal pelvis were treated with nephroureterectomy with (NUC) or without (NU) a BCE between 1988 and 2006 within 17 Surveillance, Epidemiology, and End Results registries.
  
  
  METHODS
  Cumulative incidence plots and competing risks regression models compared CSM after either NUC or NU. Covariates consisted of pathologic T and N stages, grade, age, year of surgery, gender, and race.
  
  
  CONCLUSIONS
  Respectively, 2492 (59.2%) and 1718 (40.8%) patients underwent a nephroureterectomy with or without BCE. In univariable and multivariable analyses, BCE omission increased CSM rates in patients with pT3N0/x, pT4N0/x, and pT(any)N1-3 UC of the renal pelvis. For example, in patients with pT3N0/x disease, holding all other variables constant, BCE omission increased CSM in a 1.25-fold fashion (p=0.04). Similarly, in patients with pT4N0/x disease, BCE omission resulted in a 1.45-fold increase (p=0.02). The main limitation of our study is the lack of data on disease recurrence.
  
  
  CONCLUSIONS
  Nephroureterectomy with BCE remains the standard of care in the treatment of UC of the renal pelvis and should invariably be performed in patients with locally advanced disease. Conversely, patients with pT1 and pT2 disease could be considered for NU without compromising CSM. However, recurrence data are needed to fully confirm the validity of this option.
authors.affiliation: Cancer Prognosis and Health Outcomes Unit, University of Montreal Health Center, Montreal, Québec, Canada.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lughezzani
authors.forename: Maxine
authors.initials: M
authors.lastname: Sun
authors.forename: Paul
authors.initials: P
authors.lastname: Perrotte
authors.forename: Shahrokh F
authors.initials: SF
authors.lastname: Shariat
authors.forename: Claudio
authors.initials: C
authors.lastname: Jeldres
authors.forename: Lars
authors.initials: L
authors.lastname: Budaus
authors.forename: Ahmed
authors.initials: A
authors.lastname: Alasker
authors.forename: Alain
authors.initials: A
authors.lastname: Duclos
authors.forename: Hugues
authors.initials: H
authors.lastname: Widmer
authors.forename: Mathieu
authors.initials: M
authors.lastname: Latour
authors.forename: Giorgio
authors.initials: G
authors.lastname: Guazzoni
authors.forename: Francesco
authors.initials: F
authors.lastname: Montorsi
authors.forename: Pierre I
authors.initials: PI
authors.lastname: Karakiewicz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009392:Nephrectomy / Q000379:methods* / Q000592:standards*; D017410:Practice Guidelines as Topic / Q000592:standards; D012044:Regression Analysis; D012189:Retrospective Studies; D014513:Ureter / Q000601:surgery*; D001743:Urinary Bladder / Q000601:surgery*; D019459:Urothelium / Q000473:pathology; D055815:Young Adult