title: Development of renal and iliac aneurysms in a child with generalized infantile myofibromatosis.
abstract: Infantile myofibromatosis is a rare disorder characterized by the formation of tumors in the skin, soft tissues, bone, and viscera. We report the case of a 3-week-old girl who presented with severe hypertension due to generalized infantile myofibromatosis including renal involvement. The infant was treated by chemotherapy and showed progressive regression of the tumors. However, her evolution was marked by the development of aneurismal dilations of the renal and iliac arteries as observed in fibromuscular dysplasia. We discuss the possibility of a link between these two mesenchymal disorders.
authors.affiliation: Department of Pediatric Hematology and Oncology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10, Brussels, Belgium.
authors.forename: Benoit
authors.initials: B
authors.lastname: Brasseur
authors.forename: Christophe F
authors.initials: CF
authors.lastname: Chantrain
authors.forename: Nathalie
authors.initials: N
authors.lastname: Godefroid
authors.forename: Thierry
authors.initials: T
authors.lastname: Sluysmans
authors.forename: Christine
authors.initials: C
authors.lastname: Anslot
authors.forename: Renaud
authors.initials: R
authors.lastname: Menten
authors.forename: Philippe
authors.initials: P
authors.lastname: Clapuyt
authors.forename: Sophie
authors.initials: S
authors.lastname: Dupont
authors.forename: Christiane
authors.initials: C
authors.lastname: Vermylen
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Brichard
mesh_terms: D000783:Aneurysm / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D019917:Blood Vessel Prosthesis Implantation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D017543:Iliac Aneurysm / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D007231:Infant, Newborn; D018224:Myofibromatosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011859:Radiography; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000601:surgery; D012078:Renal Artery Obstruction / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D006435:Renal Dialysis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents