Molecular cytogenetics and comparative mapping in goats (Capra hircus, 2n = 60).
Few goat genome analysis projects have been developed in the last 10 years. The aim of this review was to compile and update all available cytogenetic mapping data, according to the last goat chromosome nomenclature, as well as human and cattle whole genome sequences. In particular, human regions homologous to most of the FISH-mapped microsatellites were identified in silico. This new goat cytogenetic map made it possible to refine delineation of conserved segments relative to the human and cattle genomic sequence. These improvements did not lead to detection of major new rearrangements within ruminants but confirmed the good conservation of synteny and the numerous intrachromosomal rearrangements observed between goats and humans.
Schibler
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INRA, UMR1313, Génétique Animale et Biologie Intégrative, Jouy-en-Josas, France. laurent.schibler @ jouy.inra.fr
Di Meo
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Cribiu
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EP
Iannuzzi
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D000818:Animals; D002874:Chromosome Mapping; D020732:Cytogenetic Analysis; D006041:Goats / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence