Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes.
Quadruplex RNAs are less well understood than their DNA counterparts, yet of potentially high biological relevance. The interactions of several quadruplex-binding ligands with telomeric RNA quadruplexes are reported and compared with their binding to the analogous DNA quadruplexes.
Collie
Gavin
G
Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, UK WC1N 1AX.
Reszka
Anthony P
AP
Haider
Shozeb M
SM
Gabelica
Valérie
V
Parkinson
Gary N
GN
Neidle
Stephen
S
D001665:Binding Sites; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D006801:Humans; D008024:Ligands; D012313:RNA / Q000737:chemistry*; D016615:Telomere / Q000737:chemistry*
D008024:Ligands; D012313:RNA; D004247:DNA