title: Impact of genome assembly status on ChIP-Seq and ChIP-PET data mapping.
abstract: BACKGROUND
  ChIP-Seq and ChIP-PET can potentially be used with any genome for genome wide profiling of protein-DNA interaction sites. Unfortunately, it is probable that most genome assemblies will never reach the quality of the human genome assembly. Therefore, it remains to be determined whether ChIP-Seq and ChIP-PET are practicable with genome sequences other than a few (e.g. human and mouse).
  
  
  RESULTS
  Here, we used in silico simulations to assess the impact of completeness or fragmentation of genome assemblies on ChIP-Seq and ChIP-PET data mapping.
  
  
  CONCLUSIONS
  Most currently published genome assemblies are suitable for mapping the short sequence tags produced by ChIP-Seq or ChIP-PET.
authors.affiliation: Department Evolution des Régulation Endocriniennes, Museum National d'Histoire Naturelle, 7, Rue Cuvier, 75231 Paris Cedex 05, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Buisine
authors.forename: Laurent
authors.initials: L
authors.lastname: Sachs