title: An economic evaluation of rosuvastatin treatment in systolic heart failure: evidence from the CORONA trial.
abstract: OBJECTIVE
  To estimate the cost-effectiveness of 10 mg rosuvastatin daily for older patients with systolic heart failure in the Controlled Rosuvastatin Multinational Study in Heart Failure (CORONA) trial.
  
  
  RESULTS
  This within trial analysis of CORONA used major cardiovascular (CV) events as the outcome measure. Resource use was valued and the costs of hospitalizations, procedures, and statin use compared. Cost-effectiveness was estimated as cost per major CV event avoided. There were significantly fewer major CV events in the rosuvastatin group compared with the placebo group (1.04 vs. 1.20 per patient; difference 0.164; 95% CI: 0.075-0.254, P < 0.001). The average cost of CV hospitalizations and procedures was significantly lower for those receiving rosuvastatin ( pound1531 vs. pound1769; difference pound238; 95% CI: pound73-403, P = 0.005); the additional cost of the statin resulted in significantly higher total costs for the rosuvastatin group ( pound1769 vs. pound2072; difference pound303; 95% CI: pound138-468, P < 0.001). Overall, rosuvastatin was found to cost pound1840 (95% CI: pound562-6028) per major CV event avoided.
  
  
  CONCLUSIONS
  This economic analysis showed that a significant reduction in major CV events with rosuvastatin led to significantly reduced costs of CV hospitalizations and procedures. The reduction in associated costs for major CV events was found to offset partially (by 44%) the cost of rosuvastatin treatment in patients with systolic heart failure.
authors.affiliation: Section of Public Health and Health Policy, Faculty of Medicine, University of Glasgow, Glasgow G12 8RZ, UK.
authors.forename: Paula K
authors.initials: PK
authors.lastname: Lorgelly
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Briggs
authors.forename: Hans
authors.initials: H
authors.lastname: Wedel
authors.forename: Peter
authors.initials: P
authors.lastname: Dunselman
authors.forename: Ake
authors.initials: A
authors.lastname: Hjalmarson
authors.forename: John
authors.initials: J
authors.lastname: Kjekshus
authors.forename: Finn
authors.initials: F
authors.lastname: Waagstein
authors.forename: John
authors.initials: J
authors.lastname: Wikstrand
authors.forename: András
authors.initials: A
authors.lastname: Jánosi
authors.forename: Dirk J
authors.initials: DJ
authors.lastname: van Veldhuisen
authors.forename: Vivencio
authors.initials: V
authors.lastname: Barrios
authors.forename: Cândida
authors.initials: C
authors.lastname: Fonseca
authors.forename: John J V
authors.initials: JJ
authors.lastname: McMurray
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass / Q000706:statistics & numerical data; D003362:Cost-Benefit Analysis; D003365:Costs and Cost Analysis; D005260:Female; D005464:Fluorobenzenes / Q000191:economics* / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy / Q000191:economics*; D016027:Heart Transplantation / Q000706:statistics & numerical data; D017052:Hospital Mortality; D006760:Hospitalization / Q000191:economics* / Q000706:statistics & numerical data; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000191:economics* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011743:Pyrimidines / Q000191:economics* / Q000627:therapeutic use; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000191:economics* / Q000627:therapeutic use
chemical_list: D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011743:Pyrimidines; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium