title: Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging.
abstract: In the domain of health, one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers. Most of the existing carrier materials show poor drug loading (usually less than 5 wt% of the transported drug versus the carrier material) and/or rapid release of the proportion of the drug that is simply adsorbed (or anchored) at the external surface of the nanocarrier. In this context, porous hybrid solids, with the ability to tune their structures and porosities for better drug interactions and high loadings, are well suited to serve as nanocarriers for delivery and imaging applications. Here we show that specific non-toxic porous iron(III)-based metal-organic frameworks with engineered cores and surfaces, as well as imaging properties, function as superior nanocarriers for efficient controlled delivery of challenging antitumoural and retroviral drugs (that is, busulfan, azidothymidine triphosphate, doxorubicin or cidofovir) against cancer and AIDS. In addition to their high loadings, they also potentially associate therapeutics and diagnostics, thus opening the way for theranostics, or personalized patient treatments.
authors.affiliation: Institut Lavoisier (CNRS 8180) Institut universitaire de France, Université de Versailles, 78035 Versailles Cedex, France. horcajada@chimie.uvsq.fr
authors.forename: Patricia
authors.initials: P
authors.lastname: Horcajada
authors.forename: Tamim
authors.initials: T
authors.lastname: Chalati
authors.forename: Christian
authors.initials: C
authors.lastname: Serre
authors.forename: Brigitte
authors.initials: B
authors.lastname: Gillet
authors.forename: Catherine
authors.initials: C
authors.lastname: Sebrie
authors.forename: Tarek
authors.initials: T
authors.lastname: Baati
authors.forename: Jarrod F
authors.initials: JF
authors.lastname: Eubank
authors.forename: Daniela
authors.initials: D
authors.lastname: Heurtaux
authors.forename: Pascal
authors.initials: P
authors.lastname: Clayette
authors.forename: Christine
authors.initials: C
authors.lastname: Kreuz
authors.forename: Jong-San
authors.initials: JS
authors.lastname: Chang
authors.forename: Young Kyu
authors.initials: YK
authors.lastname: Hwang
authors.forename: Veronique
authors.initials: V
authors.lastname: Marsaud
authors.forename: Phuong-Nhi
authors.initials: PN
authors.lastname: Bories
authors.forename: Luc
authors.initials: L
authors.lastname: Cynober
authors.forename: Sophie
authors.initials: S
authors.lastname: Gil
authors.forename: Gérard
authors.initials: G
authors.lastname: Férey
authors.forename: Patrick
authors.initials: P
authors.lastname: Couvreur
authors.forename: Ruxandra
authors.initials: R
authors.lastname: Gref
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D003952:Diagnostic Imaging; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D005260:Female; D006801:Humans; D008264:Macrophages / Q000187:drug effects; D008279:Magnetic Resonance Imaging; D051379:Mice; D049329:Nanostructures / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D010316:Particle Size; D016062:Porosity; D051381:Rats
chemical_list: D003287:Contrast Media; D004337:Drug Carriers; D009942:Organometallic Compounds