Palladium-catalyzed decarboxylative benzylation of diphenylglycinate imines.
General reaction conditions for the Pd-catalyzed decarboxylative benzylation of benzyl diphenylglycinate imines are described. The overall procedure requires a simple catalyst/ligand combination to form a new Csp(3)-Csp(3) bond. Microwave irradiation greatly accelerated the transformation. Moreover, various heteroaromatic moieties are tolerated in both the imine and ester components.
Fields
Wendy H
WH
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904-4319, USA.
Chruma
Jason J
JJ
D002384:Catalysis; D003653:Decarboxylation; D005998:Glycine / Q000031:analogs & derivatives / Q000737:chemistry*; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D007097:Imines; D009942:Organometallic Compounds; D010165:Palladium; D005998:Glycine