Dydrogesterone support in threatened miscarriage.
BACKGROUND
The aim of this study was to determine whether dydrogesterone helps to preserve pregnancy in women with threatened miscarriage.


METHODS
146 women who presented with mild or moderate vaginal bleeding during the first trimester of pregnancy were randomised to receive oral dydrogesterone (10mg b.i.d.) (n=86) or no treatment (n=60). Dydrogesterone was continued until 1 week after the bleeding had stopped. All women received standard supportive care.


RESULTS
The incidence of miscarriage was significantly lower in the dydrogesterone group than in the untreated group (17.5% vs. 25%; p<0.05). There were no statistically significant differences between the groups with respect to pregnancy complications or congenital abnormalities.


CONCLUSIONS
Dydrogesterone appears to have beneficial effects in women with threatened miscarriage.
El-Zibdeh
Mazen Y
MY
Department of Obstetrics and Gynaecology, Islamic Hospital, Amman, Jordan. drmazen@go.com.jo
Yousef
Lama T
LT
D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000517:prevention & control*; D000033:Abortion, Threatened / Q000188:drug therapy*; D000328:Adult; D000013:Congenital Abnormalities / Q000453:epidemiology; D004394:Dydrogesterone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015994:Incidence; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011372:Progestins / Q000627:therapeutic use*; D012102:Reproductive Control Agents / Q000627:therapeutic use*; D055815:Young Adult
D011372:Progestins; D012102:Reproductive Control Agents; D004394:Dydrogesterone