Genome-wide gene-based analysis of rheumatoid arthritis-associated interaction with PTPN22 and HLA-DRB1.
The genes PTPN22 and HLA-DRB1 have been found by a number of studies to confer an increased risk for rheumatoid arthritis (RA), which indicates that both genes play an important role in RA etiology. It is believed that they not only have strong association with RA individually, but also interact with other related genes that have not been found to have predisposing RA mutations. In this paper, we conduct genome-wide searches for RA-associated gene-gene interactions that involve PTPN22 or HLA-DRB1 using the Genetic Analysis Workshop 16 Problem 1 data from the North American Rheumatoid Arthritis Consortium. MGC13017, HSPCAL3, MIA, PTPNS1L, and IGLVI-70, which showed association with RA in previous studies, have been confirmed in our analysis.
Qiao
Bo
B
Department of Statistics, Columbia University, 1255 Amsterdam Avenue, 10th Floor, MC4690, New York, New York 10027, USA. bq2108@columbia.edu.
Huang
Chien Hsun
CH
Cong
Lei
L
Xie
Jun
J
Lo
Shaw-Hwa
SH
Zheng
Tian
T