title: Optimum pyrolytic conditions for furan derivative formation from polyamino sugars.
abstract: Furan derivatives were prepared by hydrolysis of glucosamine derived from polyamino sugars assisted with pyrolysis in alkaline condition. Pyrolysis was carried out with autoclaving at 15 psi/121 degrees C/1 hour. The reaction was monitored by observing spectral characteristics at lambda(max) 545 nm with p-dimethylaminobenzaldehyde. Alkaline hydrolysis favors the formation of furan derivatives in N-acetylglucosamine, glucosamine, hyaluronic acid, but not in dermatan sulfate and chondroitin sulfate. These results indicate -OH group orientation in the cis position at C(4) of the Haworth projection formula of hexosamines may be playing a role in the formation of furans. This can be a useful method for estimation of the glucosamine in glycoprotein and urine.
authors.affiliation: Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore, India. badadani@gmail.com
authors.forename: Mallikarjun
authors.initials: M
authors.lastname: Badadani
authors.forename: K Taranath
authors.initials: KT
authors.lastname: Shetty
mesh_terms: D000606:Amino Sugars / Q000737:chemistry*; D005663:Furans / Q000737:chemistry*; D005944:Glucosamine / Q000737:chemistry*; D006868:Hydrolysis; D013053:Spectrophotometry
chemical_list: D000606:Amino Sugars; D005663:Furans; D005944:Glucosamine