title: Follow-up study of the GIGYF2 gene in French families with Parkinson's disease.
abstract: Meeus et al. (2009) reported no pathogenic mutations in a comprehensive genetic analysis of the entire GRB10-interacting GYF protein-2 gene (GIGYF2) in a Belgian series of both familial and sporadic patients with Parkinson's disease (PD). Although we initially proposed that GIGYF2 corresponds to the PARK11 locus, in familial PD, we found no causative variations in a follow-up study in which GIGYF2 was screened in an independent series of 185 patients with autosomal dominant PD, mostly of French origin. Together, these results do not support a major role of GIGYF2 in PD.
authors.affiliation: INSERM, UMR_S975 (Formerly UMR_S679), Hôpital de la Salpêtrière, Paris, France.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Lesage
authors.forename: Christel
authors.initials: C
authors.lastname: Condroyer
authors.forename: Ebba
authors.initials: E
authors.lastname: Lohman
authors.forename: André
authors.initials: A
authors.lastname: Troiano
authors.forename: François
authors.initials: F
authors.lastname: Tison
authors.forename: François
authors.initials: F
authors.lastname: Viallet
authors.forename: Philippe
authors.initials: P
authors.lastname: Damier
authors.forename: Christine
authors.initials: C
authors.lastname: Tranchant
authors.forename: Marie
authors.initials: M
authors.lastname: Vidhaillet
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Ouvrard-Hernandez
authors.forename: Alexandra
authors.initials: A
authors.lastname: Dürr
authors.forename: Alexis
authors.initials: A
authors.lastname: Brice
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002352:Carrier Proteins / Q000235:genetics*; D005192:Family Health; D005260:Female; D005500:Follow-Up Studies; D005602:France; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D055815:Young Adult
chemical_list: D002352:Carrier Proteins; C478016:GIGYF2 protein, human