Comparison of interferon gamma and interferon gamma-inducible protein-10 secretion in HIV-tuberculosis patients.
Interferon gamma (IFNgamma)-based in-vitro assays have suboptimal sensitivity, especially in immunocompromised individuals, which emphasizes the need for alternative markers for tuberculosis (TB) diagnosis. We compared TB antigens-specific IFNgamma and IFNgamma-inducible protein-10 levels in culture of whole blood samples from HIV-TB patients. We report that IFNgamma-inducible protein-10 detects a greater number of HIV-TB cases than IFNgamma and suggest that IFNgamma-inducible protein-10 may be a better alternative marker for latent TB infection diagnosis among immunocompromised individuals.
Kabeer
Basirudeen S A
BS
Department of Immunology, Tuberculosis Research Centre, India.
Sikhamani
Rajasekaran
R
Raja
Alamelu
A
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000276:immunology; D015415:Biomarkers / Q000378:metabolism; D054357:Chemokine CXCL10 / Q000378:metabolism*; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D014376:Tuberculosis / Q000175:diagnosis* / Q000276:immunology
D015415:Biomarkers; D054357:Chemokine CXCL10; D007371:Interferon-gamma