Modulation of antioxidative response in the therapy of hypertension and other cardiovascular diseases.
OBJECTIVE
This paper reviews and compares major approaches and strategies to modulation of antioxidative response in the therapy of hypertension and cardiovascular diseases.


METHODS
There are two major strategies of modulation of antioxidative response in hypertension and cardiovascular diseases: (i) modulation of NO levels by NOS stimulation, increase of NO bioavailability, administration of NO, and NOS gene incorporation; (ii) scavenging of superoxide and suppression of oxidative stress by activation of antioxidant gene expression or by suppression of selected genes by RNA silencing. These strategies are accomplished by several concepts, including (1) delivery of external agents, (2) antioxidant gene therapy and RNA silencing, and (3) combined therapies and approaches.


CONCLUSIONS
Combined therapies and approches often achieve multiplicative effects and are the most promising attitude in antioxidant-oriented therapy of hypertension and cardiovascular diseases.
Dovinova
Ima
I
Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Slovakia. ima.dovinova@savba.sk
Gardlik
Roman
R
Palffy
Roland
R
Kristek
Frantisek
F
Cacanyiova
Sona
S
Vantova
Zuzana
Z
Paulikova
Helena
H
D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000628:therapy*; D006801:Humans; D006973:Hypertension / Q000378:metabolism* / Q000628:therapy*
D000975:Antioxidants