title: Neuroprotective activity of Matricaria recutita Linn against global model of ischemia in rats.
abstract: BACKGROUND
  Traditionally, the whole plant is used for various diseases, including neuronal disorders.
  
  
  OBJECTIVE
  To evaluate the neuroprotective effect of Matricaria recutita L. against global cerebral ischemia/reperfusion (I/R) injury-induced oxidative stress in rats.
  
  
  METHODS
  Neuroprotective activity was carried out by global cerebral ischemia on Sprague-Dawley rats by bilateral carotid artery (BCA) occlusion for 30 min followed by 60 min reperfusion. The antioxidant enzymatic and non-enzymatic levels were estimated along with cerebral infarction area and histopathological studies.
  
  
  RESULTS
  The Matricaria recutita L. methanolic extract showed dose-dependent neuroprotective activity by significant decrease in lipid peroxidation (LPO) and increase in the superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and total thiol levels in extract treated groups as compared to ischemia/reperfusion group. Cerebral infarction area was significantly reduced in extract treated groups as compared to ischemia/reperfusion group.
  
  
  CONCLUSIONS
  The methanolic extract of Matricaria recutita L. showed potent neuroprotective activity against global cerebral ischemia/reperfusion injury-induced oxidative stress in rats.
authors.affiliation: Department of Pharmacology, Hanagal Shri Kumareshawr College of Pharmacy, BVVS campus, Bagalkot-587101, Karnataka, India. chandupharm@yahoo.com
authors.forename: V M
authors.initials: VM
authors.lastname: Chandrashekhar
authors.forename: V L
authors.initials: VL
authors.lastname: Ranpariya
authors.forename: S
authors.initials: S
authors.lastname: Ganapaty
authors.forename: A
authors.initials: A
authors.lastname: Parashar
authors.forename: A A
authors.initials: AA
authors.lastname: Muchandi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism; D002544:Cerebral Infarction / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004798:Enzymes / Q000378:metabolism; D005260:Female; D056626:Inflorescence; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D031168:Matricaria; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control
chemical_list: D000975:Antioxidants; D004798:Enzymes; D018696:Neuroprotective Agents; D010936:Plant Extracts