title: Clinicopathological study of 13 cases of squamous cell carcinoma complicating hidradenitis suppurativa.
abstract: BACKGROUND
  To the best of our knowledge, only 52 cases of squamous cell carcinoma (SCC) complicating hidradenitis suppurativa (HS) have been reported since 1958. We describe 13 new cases.
  
  
  METHODS
  We propose a clinical and histological analysis of our cases. We include these results in a review of previously reported cases to analyze a total of 65 patients. In our series of 13 cases, we also investigate the presence of human papillomavirus (HPV) in tumor samples, by polymerase chain reaction (PCR) on paraffin-embedded material.
  
  
  RESULTS
  Malignant transformation affects mainly men with a long-term history of genitoanal HS. Although our cases were 7 well-differentiated carcinomas and 6 verrucous carcinomas, lymphatic and visceral metastasis occurred in 2 and 3 cases, respectively. With PCR, we demonstrated presence of HPV in genitoanal tumoral lesions, principally HPV-16.
  
  
  CONCLUSIONS
  SCC complicating HS evolves poorly, despite a good histological prognosis. Our results sustain the implication of HPV in the malignant transformation of HS.
authors.affiliation: Université de Lille 2 et Clinique de Dermatologie, CHRU de Lille, Lille, France.
authors.forename: C
authors.initials: C
authors.lastname: Lavogiez
authors.forename: E
authors.initials: E
authors.lastname: Delaporte
authors.forename: S
authors.initials: S
authors.lastname: Darras-Vercambre
authors.forename: E
authors.initials: E
authors.lastname: Martin De Lassalle
authors.forename: C
authors.initials: C
authors.lastname: Castillo
authors.forename: X
authors.initials: X
authors.lastname: Mirabel
authors.forename: F
authors.initials: F
authors.lastname: Laurent
authors.forename: P
authors.initials: P
authors.lastname: Patenotre
authors.forename: T
authors.initials: T
authors.lastname: Gheit
authors.forename: J C
authors.initials: JC
authors.lastname: Talmant
authors.forename: M
authors.initials: M
authors.lastname: Beylot-Barry
authors.forename: V
authors.initials: V
authors.lastname: Martinot
authors.forename: F
authors.initials: F
authors.lastname: Piette
authors.forename: F
authors.initials: F
authors.lastname: Aubin
authors.forename: L
authors.initials: L
authors.lastname: Mortier
mesh_terms: D000293:Adolescent; D000328:Adult; D001005:Anus Neoplasms / Q000150:complications / Q000473:pathology* / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology* / Q000821:virology; D018289:Carcinoma, Verrucous / Q000150:complications / Q000473:pathology / Q000821:virology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005260:Female; D017497:Hidradenitis Suppurativa / Q000150:complications / Q000473:pathology* / Q000821:virology; D052162:Human papillomavirus 16; D006801:Humans; D008297:Male; D030361:Papillomavirus Infections / Q000150:complications / Q000473:pathology*; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects; D014565:Urogenital Neoplasms / Q000150:complications / Q000473:pathology* / Q000821:virology; D055815:Young Adult