title: A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han population.
abstract: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with complex genetic inheritance. Recently, single-nucleotide polymorphisms (SNPs) in tumor necrosis factor (TNF) superfamily gene TNFSF4 have been shown to be associated with SLE in European and Hong Kong Chinese populations. But it is unknown whether it is also associated with the disease in Mainland Chinese Han population. We genotyped the SNPs rs1234315 near the TNFSF4 gene in 1,344 SLE patients and 4,315 controls of Chinese Han population and confirmed the association between the SNP and the SLE [odds ratios (ORs) of 1.45 and P values of 1.5 × 10(-16)]. The stratification analyses showed that rs1234315 was more strongly associated with SLE patients with arthritis. Our study not only suggested that the TNFSF4 gene was associated with SLE in Chinese Han population, but also implied that it might be a common genetic factor predisposing to the development of SLE in multiple populations.
authors.affiliation: Department of Dermatology, Institute of Dermatology, No. 1 Hospital, Anhui Medical University, 69 Meishan Road, 230032, Hefei, Anhui, China.
authors.forename: Sheng-Quan
authors.initials: SQ
authors.lastname: Zhang
authors.forename: Jian-Wen
authors.initials: JW
authors.lastname: Han
authors.forename: Liang-Dan
authors.initials: LD
authors.lastname: Sun
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Lu
authors.forename: Xian-Yong
authors.initials: XY
authors.lastname: Yin
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D053278:OX40 Ligand / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D053278:OX40 Ligand; C089251:TNFSF4 protein, human