title: Esophageal cyst producing CA19-9 and CA125.
abstract: The patient was a 59-year-old woman in whom computed tomography revealed a posterior mediastinal cyst and ovarian cystoma at a medical check-up in March 2007. Blood tests showed high CA19-9 and CA125 levels. She underwent left adnexectomy for ovarian cystoma in July 2008 and histopathological examination led to a diagnosis of dermoid cyst. The postoperative levels of CA19-9 and CA125 remained high. She developed dysphagia in February 2009, and the posterior mediastinal cyst showed a tendency to enlarge. Therefore, she underwent tumorectomy through a small thoracotomy. The cyst contained greenish fluid with CA19-9 and CA125 contents of 65,000 and 78,000 U/ml, respectively. Histologically, the cyst had a thickened wall, which contained two muscle layers, and was lined by squamous and pseudostratified ciliated epithelium. No cartilage or bronchial glands were identified. These findings led to a diagnosis of esophageal cyst. On immunohistochemical staining, the cyst-lining epithelial cells were positive for CA19-9 and CA125. The serum CA19-9 and CA125 levels returned to normal two months after surgery. We report a resected case of esophageal cyst producing CA19-9 and CA125.
authors.affiliation: Department of General Thoracic Surgery, National Hospital Organization Tokyo Medical Center, Meguro-ku, Tokyo, Japan. tgoto@ntmc.hosp.go.jp
authors.forename: Taichiro
authors.initials: T
authors.lastname: Goto
authors.forename: Arafumi
authors.initials: A
authors.lastname: Maeshima
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Oyamada
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Kato
mesh_terms: D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood*; D003680:Deglutition Disorders / Q000209:etiology; D004934:Esophageal Cyst / Q000150:complications / Q000175:diagnosis / Q000276:immunology* / Q000601:surgery; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D010048:Ovarian Cysts / Q000276:immunology / Q000601:surgery; D013906:Thoracoscopy; D013908:Thoracotomy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins