Schweinfurthins I and J from Macaranga schweinfurthii.
Demand for the experimental antineoplastic agent schweinfurthin A, for developmental testing, prompted a re-collection of leaf material of Macaranga schweinfurthii from the original collection site in Cameroon. During chromatographic purification of the organic solvent extract, analytical UPLC-PDA-TOFMS of stilbene-enriched fractions revealed the presence of six known schweinfurthins and two previously unknown stilbenes. The structures of these new compounds, schweinfurthins I and J (1 and 2), were elucidated by 1D- and 2D-NMR techniques.
Klausmeyer
Paul
P
Natural Products Support Group, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA.
Van
Que N
QN
Jato
Johnson
J
McCloud
Thomas G
TG
Beutler
John A
JA
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002163:Cameroon; D019665:Euphorbiaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; C548941:schweinfurthin I; C548942:schweinfurthin J