title: Differences between tuberculosis cases infected with Mycobacterium africanum, West African type 2, relative to Euro-American Mycobacterium tuberculosis: an update.
abstract: Mycobacterium africanum (MAF) is a common cause of human pulmonary tuberculosis in West Africa. We previously described phenotypic differences between MAF and Mycobacterium tuberculosis (MTB) among 290 patients. In the present analysis, we compared 692 tuberculosis patients infected with the two most common lineages within the (MTB) complex found in the Gambia, namely MAF West African type 2 (39% prevalence) and Euro-American MTB (55% prevalence). We identified additional phenotypic differences between infections with these two organisms. MAF patients were more likely to be older and HIV infected. In addition, they had worse disease on chest X-ray, despite complaining of cough for an equal duration, and were more likely severely malnourished. In this cohort, the prevalence of MAF did not change significantly over a 7-year period.
authors.affiliation: Bacterial Diseases Programme, MRC Laboratories, Banjul, The Gambia. bdejong@mrc.gm
authors.forename: Bouke C
authors.initials: BC
authors.lastname: de Jong
authors.forename: Ifedayo
authors.initials: I
authors.lastname: Adetifa
authors.forename: Brigitte
authors.initials: B
authors.lastname: Walther
authors.forename: Philip C
authors.initials: PC
authors.lastname: Hill
authors.forename: Martin
authors.initials: M
authors.lastname: Antonio
authors.forename: Martin
authors.initials: M
authors.lastname: Ota
authors.forename: Richard A
authors.initials: RA
authors.lastname: Adegbola
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D000328:Adult; D000569:Americas / Q000453:epidemiology; D005060:Europe / Q000453:epidemiology; D005260:Female; D005714:Gambia / Q000453:epidemiology; D005838:Genotype; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology / Q000821:virology; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000150:complications / Q000453:epidemiology; D009161:Mycobacterium / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D010641:Phenotype; D015995:Prevalence; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D055815:Young Adult