title: Study of acute hepatotoxicity of Equisetum arvense L. in rats.
abstract: OBJECTIVE
  To evaluate the acute hepatotoxicity of Equisentum arvense L. in rats.
  
  
  METHODS
  Fifty Wistar rats were used, these being divided in four groups, one being the control (receiving only water) and the other groups receiving graded doses of Equisentum arvense L. (30, 50, and 100mg/kg respectively) for 14 days. Blood samples were obtained to determine TGO, TGP, FA, DHL and GT-gamma activities. After that, hepatic tissue samples were collected for the anatomopathologic analysis.
  
  
  RESULTS
  The anatomopathologic exam of the hepatic tissue showed organ with preserved lobular structure. In the same way, there was no significant change in the seric activities of the hepatic enzymes when compared to control group.
  
  
  CONCLUSIONS
  The oral treatment with graded doses of Equisentum arvense L. was not able to produce hepatic changes. Further studies are necessary to evaluate the chronic hepatotoxicity of Equisentum arvense L. in rats.
authors.affiliation: Itajubá School of Medicine, Rua Marechal Juarez Távora 180, Itajubá, Minas Gerais, Brazil. nilocvbaracho@yahoo.com.br
authors.forename: Nilo César do Vale
authors.initials: NC
authors.lastname: Baracho
authors.forename: Bruno Battiston Vilela
authors.initials: BB
authors.lastname: Vicente
authors.forename: Guilherme D'Andréa Saba
authors.initials: GD
authors.lastname: Arruda
authors.forename: Brunno Cezar Framil
authors.initials: BC
authors.lastname: Sanches
authors.forename: Jarbas de
authors.initials: Jd
authors.lastname: Brito
mesh_terms: D000818:Animals; D020829:Equisetum / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D023421:Models, Animal; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric
chemical_list: D010936:Plant Extracts