Fibre optic microarrays.
This tutorial review describes how fibre optic microarrays can be used to create a variety of sensing and measurement systems. This review covers the basics of optical fibres and arrays, the different microarray architectures, and describes a multitude of applications. Such arrays enable multiplexed sensing for a variety of analytes including nucleic acids, vapours, and biomolecules. Polymer-coated fibre arrays can be used for measuring microscopic chemical phenomena, such as corrosion and localized release of biochemicals from cells. In addition, these microarrays can serve as a substrate for fundamental studies of single molecules and single cells. The review covers topics of interest to chemists, biologists, materials scientists, and engineers.
Walt
David R
DR
Department of Chemistry, Tufts University, Medford, MA 02116, USA. david.walt@tufts.edu
D000818:Animals; D006801:Humans; D046228:Microarray Analysis / Q000295:instrumentation / Q000379:methods*; D057054:Molecular Imaging; D020411:Oligonucleotide Array Sequence Analysis; D055100:Optical Fibers; D040081:Protein Array Analysis; D046888:Tissue Array Analysis