title: Acute phase response in porcine reproductive and respiratory syndrome virus infection.
abstract: This study was focused on the changes observed in the serum concentration of haptoglobin (Hp), C-reactive protein (CRP), serum amyloid A (SAA) and Pig-major acute protein (Pig-MAP), during experimental porcine reproductive and respiratory syndrome virus (PRRSV) infection and in their relationship with the expression of interleukin 1β (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α). Hp and Pig-MAP serum levels were increased at 10 dpi, but CRP and SAA showed a delayed and highly variable increase. All three proinflammatory cytokines were poorly expressed, and only a mild increase in IL-1β was observed at 7 dpi. The increased expression of Hp coincided with the light enhancement observed in both IL-6 and TNF-α, and might be related with an increased expression of IL-10. The low expression of TNF-α might point to a possible mechanism of viral evasion of host-immune response. This issue and the delayed expression of CRP and SAA should be taken into account in future studies about modulation of the immune response by PRRSV infection.
authors.affiliation: Department of Anatomy and Comparative Pathology, Faculty of Veterinary Medicine, Cordoba University, 14014 Cordoba, Spain. v92golaj@uco.es
authors.forename: J
authors.initials: J
authors.lastname: Gómez-Laguna
authors.forename: F J
authors.initials: FJ
authors.lastname: Salguero
authors.forename: F J
authors.initials: FJ
authors.lastname: Pallarés
authors.forename: M
authors.initials: M
authors.lastname: Fernández de Marco
authors.forename: I
authors.initials: I
authors.lastname: Barranco
authors.forename: J J
authors.initials: JJ
authors.lastname: Cerón
authors.forename: S
authors.initials: S
authors.lastname: Martínez-Subiela
authors.forename: K
authors.initials: K
authors.lastname: Van Reeth
authors.forename: L
authors.initials: L
authors.lastname: Carrasco
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis* / Q000235:genetics / Q000378:metabolism; D000210:Acute-Phase Reaction; D000818:Animals; D002097:C-Reactive Protein / Q000032:analysis / Q000378:metabolism; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006242:Haptoglobins / Q000032:analysis / Q000378:metabolism; D056747:Immunomodulation; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D019318:Porcine Reproductive and Respiratory Syndrome / Q000097:blood* / Q000276:immunology* / Q000473:pathology / Q000821:virology; D019316:Porcine respiratory and reproductive syndrome virus / Q000302:isolation & purification / Q000502:physiology; D000685:Serum Amyloid A Protein / Q000032:analysis / Q000378:metabolism; D013552:Swine; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014766:Viremia / Q000662:veterinary
chemical_list: D000209:Acute-Phase Proteins; D002097:C-Reactive Protein; D016207:Cytokines; D006242:Haptoglobins; D053583:Interleukin-1beta; D015850:Interleukin-6; D000685:Serum Amyloid A Protein; D014409:Tumor Necrosis Factor-alpha; C095815:ITIH4 protein, Sus scrofa