title: Late life depression: a comparison of risk factors and symptoms according to age of onset in community dwelling older adults.
abstract: BACKGROUND
  It has been reported that late onset depression is more frequently associated with acquired organic pathology and that patients are less likely to report a family history of depression. Differences in phenomenology according to age of onset have been described although these have not been consistently replicated. The majority of these studies have been in hospital populations. The aim of this study is to address this question in a sample of community dwelling older adults.
  
  
  METHODS
  89 subjects with GMS-AGECAT depression were identified from a sample of 1231 community dwelling adults aged 65 years and over. Subjects were analysed across a range of aetiological and phenomenological variables according to age of onset of first depressive episode.
  
  
  RESULTS
  Subjects with late onset depression (≥ 60) were significantly less likely to report a family history of depression, were less likely to report previous hospitalisation for depression and had greater cognitive impairment. Late onset subjects were also less likely to report feelings of guilt or thoughts that life was not worth living in the previous month.
  
  
  CONCLUSIONS
  While we found that patients with late onset depression differed from early onset patients according to certain aetiological risk factors, we did not find a distinctive profile of depressive symptomatology which might be considered clinically useful at an individual level. These findings are consistent with studies based in hospital populations.
authors.affiliation: Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland. dgallagher2@stjames.ie
authors.forename: Damien
authors.initials: D
authors.lastname: Gallagher
authors.forename: Aine Ni
authors.initials: AN
authors.lastname: Mhaolain
authors.forename: Elaine
authors.initials: E
authors.lastname: Greene
authors.forename: Cathal
authors.initials: C
authors.lastname: Walsh
authors.forename: Aisling
authors.initials: A
authors.lastname: Denihan
authors.forename: Irene
authors.initials: I
authors.lastname: Bruce
authors.forename: Jeannette
authors.initials: J
authors.lastname: Golden
authors.forename: Ronan M
authors.initials: RM
authors.lastname: Conroy
authors.forename: Michael
authors.initials: M
authors.lastname: Kirby
authors.forename: Brian A
authors.initials: BA
authors.lastname: Lawlor
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D003866:Depressive Disorder / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D009660:Northern Ireland / Q000453:epidemiology; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors