title: Acquired perforating dermatosis associated with pregnancy.
abstract: Acquired perforating collagenosis (APC) is a rare condition in which altered collagen and elastin fibres undergo transepidermal elimination. The pathogenesis is unknown but it is usually associated with underlying systemic disease, most commonly diabetes mellitus and renal impairment. We describe a case of an acquired perforating disorder occurring in pregnancy. APC is a diagnosis that can easily be missed, especially in atypical cases such as ours, and clinicians and histopathologists need to be aware of this condition to avoid unnecessary patient morbidity.
authors.affiliation: Whipps Cross University Hospital NHS Trust, Barts and the London NHS Trust, London, UK. rachealy@hotmail.com
authors.forename: R
authors.initials: R
authors.lastname: Healy
authors.forename: R
authors.initials: R
authors.lastname: Cerio
authors.forename: A
authors.initials: A
authors.lastname: Hollingsworth
authors.forename: A
authors.initials: A
authors.lastname: Bewley
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005436:Floxacillin / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D011239:Prednisolone / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000473:pathology*; D012871:Skin Diseases / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D005938:Glucocorticoids; D005436:Floxacillin; D011239:Prednisolone