Total solid-phase synthesis of NOTA-functionalized peptides for PET imaging.
A convenient approach to functionalize peptides either at the N-terminal or on a lysine side chain with 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) chelating unit has been developed on solid support. The chelate was assembled in a two-step process starting with bromo-acetylated peptides. Deprotection and cleavage of the resin-bound NOTA peptides were performed with use of trifluoroacetic acid (TFA) in the presence of thioanisole and water to give free NOTA peptides.
Guérin
Brigitte
B
Centre d'imagerie moléculaire de Sherbrooke (CIMS), Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Québec, Canada J1H 5N4. brigitte.guerin2@usherbrooke.ca
Ait-Mohand
Samia
S
Tremblay
Marie-Claude
MC
Dumulon-Perreault
Véronique
V
Fournier
Patrick
P
Bénard
François
F
D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006573:Heterocyclic Compounds, 1-Ring; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D049268:Positron-Emission Tomography
D006571:Heterocyclic Compounds; D006573:Heterocyclic Compounds, 1-Ring; D010455:Peptides; C048993:1,4,7-triazacyclononane-N,N',N''-triacetic acid