Efficient growth inhibition of human osteosarcoma cells using a peptide derived from the MDM-2-binding site of p53.
Protein transduction therapy is a promising alternative to gene therapy, but has not previously been investigated for osteosarcoma. We here demonstrate efficient growth inhibition of human osteosarcoma cells using a p53 peptide. Our result suggests that protein transduction therapy has significant potential as a novel therapeutic approach for osteosarcoma.
Ito
R
R
Department of Orthopaedic Surgery, Yokohama City University School of Medicine, Yokohama, Japan. wakkyoi5115@hotmail.com
Kanno
H
H
Takahashi
A
A
Matsumoto
R
R
Kobayashi
N
N
Yoshida
T
T
Saito
T
T
D000595:Amino Acid Sequence; D000704:Analysis of Variance; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics / Q000378:metabolism; D001665:Binding Sites; D001859:Bone Neoplasms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008969:Molecular Sequence Data; D012516:Osteosarcoma / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010455:Peptides / Q000235:genetics / Q000378:metabolism; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology
D000952:Antigens, Polyomavirus Transforming; D010455:Peptides; D011993:Recombinant Fusion Proteins; D016159:Tumor Suppressor Protein p53; C015462:polyarginine; D051736:Proto-Oncogene Proteins c-mdm2