title: [A novel mechanism for H. pylori-induced cell damage--induction of gene mutation by AID].
abstract: H. pylori infection causes gastric cancer development through gastritis. However, the precise mechanism for H. pylori-induced carcinogenesis remains unclear. On the other hand, accumulation of gene mutations is a hallmark of cancers, but mechanism of endogenous induction of mutation also remains unknown. Here, we found that H. pylori infection triggers aberrant expression of activation-induced cytidine deaminase (AID), a molecule that can induce DNA somatic hypermutation of immunoglobulin gene in B cells under physiological condition, in the gastric mucosa via NFkappaB-dependent mechanism. Induction of AID then enhances various gene mutations including p53. This mechanism appears to play important roles in gastric carcinogenesis by H. pylori infection.
authors.affiliation: Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Chiba
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Marusawa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Matsumoto
mesh_terms: D000818:Animals; D003564:Cytidine Deaminase / Q000502:physiology*; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D009154:Mutation; D013274:Stomach Neoplasms / Q000209:etiology*
chemical_list: D003564:Cytidine Deaminase