title: Increased IL-17-producing cells correlate with poor survival and lymphangiogenesis in NSCLC patients.
abstract: The presence of IL-17-positive cells is observed in a variety of inflammatory associated cancers and IL-17 has been found to be involved in angiogenesis. The aim of this study is to determine the prognostic significance of IL-17 in NSCLC patients and to examine the correlation between IL-17 expression and lymphatic vessel density in NSCLC tissues. The expression of IL-17 was measured by immunohistochemistry in 52 paraffin-embedded tissues with non-small cell lung cancer. The chi(2) test was used to analyze the correlation between IL-17 expression and clinical parameters and lymphatic vessel density (LVD). The Kaplan-Meier method, univariate and multivariate regression analysis was used to analyze the correlation between IL-17 expression and overall survival and disease-free survival. High expression of IL-17 was observed in 25 of 52 lung cancer patients and was associated with smoking status, TNM stage, LVD, overall survival and disease-free survival. Univariate and multivariate analysis showed that IL-17 was an independent prognostic factor for overall survival and disease-free survival. Our results indicate that IL-17 may play a role in the metastasis of lung cancer by promoting lymphangiogenesis. IL-17 expression is an independent prognostic factor in both overall and disease-free survival in NSCLC.
authors.affiliation: Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Xinqiao Street No 30, Chongqing 400037, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Jin
authors.initials: J
authors.lastname: Wan
authors.forename: Jiankun
authors.initials: J
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Xie
authors.forename: Xinwei
authors.initials: X
authors.lastname: Diao
authors.forename: Jianping
authors.initials: J
authors.lastname: Xu
authors.forename: Bo
authors.initials: B
authors.lastname: Zhu
authors.forename: Zhengtang
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000098:blood supply / Q000175:diagnosis* / Q000276:immunology* / Q000401:mortality / Q000473:pathology / Q000503:physiopathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000276:immunology* / Q000401:mortality; D042583:Lymphangiogenesis / Q000502:physiology; D042601:Lymphatic Vessels / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000276:immunology; D011237:Predictive Value of Tests; D011379:Prognosis; D012907:Smoking
chemical_list: D020381:Interleukin-17