Small molecule induced control in duplex and triplex DNA-directed chemical reactions.
Triplex DNA binders can effectively control copper-catalysed alkyne-azide click reactions in DNA architecture, such that either duplex or triplex DNA directed reactions of terminally attached azides and alkynes occur, in the absence or presence of triplex DNA binder, respectively.
Jacobsen
Mikkel F
MF
Danish Research Foundation: Centre for DNA Nanotechnology at the Interdisciplinary Nanoscience Center and the Department of Chemistry, AarhusUniversity, Langelandsgade 140, 8000 Aarhus C, Denmark.
Ravnsbaek
Jens B
JB
Gothelf
Kurt V
KV
D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D001483:Base Sequence; D001600:Berberine Alkaloids / Q000737:chemistry; D001665:Binding Sites; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D011804:Quinolines / Q000737:chemistry
D000480:Alkynes; D001386:Azides; D001600:Berberine Alkaloids; D011804:Quinolines; C102232:naphthylquinoline triple-helix-binding ligand; C051802:triplex DNA; C000666:coralyne; D003300:Copper; D004247:DNA