Celiac disease: prevention and treatment.
Celiac disease is a common multisystemic disorder that may be diagnosed at any age. Owing to the increasing prevalence, prevention strategies, including encouragement of breastfeeding and introduction of small amounts of gluten whereas still on breastfeeding at fourth to sixth month of age, become more important than before. For avoiding complications of celiac disease, a strict gluten-free diet is essential. A lifelong gluten-free diet may bring about difficulties as avoiding gluten completely is problematic owing to the contamination with gluten of presumably gluten free foods. New therapeutic approaches include enzyme supplementation, correction of the intestinal barrier defect against gluten entry, blocking of gliadin presentation by human leukocyte antigen blockers and tissue transglutaminase inhibitors.
Selimoğlu
Mukadder Ayşe
MA
Inönü University, Faculty of Medicine, Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Malatya, Turkey. ayseselimoglu@hotmail.com
Karabiber
Hamza
H
D000818:Animals; D001942:Breast Feeding; D002446:Celiac Disease / Q000276:immunology / Q000517:prevention & control / Q000628:therapy*; D055050:Diet, Gluten-Free; D057487:Enzyme Therapy; D005903:Gliadin / Q000276:immunology; D005983:Glutens / Q000008:administration & dosage* / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000378:metabolism; D011503:Transglutaminases / Q000037:antagonists & inhibitors
D006680:HLA Antigens; D005983:Glutens; D005903:Gliadin; D011503:Transglutaminases