title: Schweinfurthins I and J from Macaranga schweinfurthii.
abstract: Demand for the experimental antineoplastic agent schweinfurthin A, for developmental testing, prompted a re-collection of leaf material of Macaranga schweinfurthii from the original collection site in Cameroon. During chromatographic purification of the organic solvent extract, analytical UPLC-PDA-TOFMS of stilbene-enriched fractions revealed the presence of six known schweinfurthins and two previously unknown stilbenes. The structures of these new compounds, schweinfurthins I and J (1 and 2), were elucidated by 1D- and 2D-NMR techniques.
authors.affiliation: Natural Products Support Group, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Klausmeyer
authors.forename: Que N
authors.initials: QN
authors.lastname: Van
authors.forename: Johnson
authors.initials: J
authors.lastname: Jato
authors.forename: Thomas G
authors.initials: TG
authors.lastname: McCloud
authors.forename: John A
authors.initials: JA
authors.lastname: Beutler
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002163:Cameroon; D019665:Euphorbiaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; C548941:schweinfurthin I; C548942:schweinfurthin J