title: Human papillomavirus-associated oropharyngeal cancer: a new clinical entity.
abstract: The incidence of oropharyngeal cancers is rising worldwide in both nonsmokers and nondrinkers. Epidemiology studies suggest a strong association between human papillomavirus (HPV) 16 infection, changing sexual behavior and cancer development. Despite initial presentation with locally advanced disease and poorly differentiated histology, HPV-associated oropharyngeal carcinoma is associated with a good prognosis because its response to chemotherapy and radiation. Clinicians should be aware of the risk of oropharyngeal cancer in young people to avoid unnecessary delay in diagnosis and treatment. A history of oral sex should be elicited in young patients with enlarged neck nodes and/or tonsillar masses.
authors.affiliation: Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724-5081, USA. namphong.nguyen@yahoo.com
authors.forename: N P
authors.initials: NP
authors.lastname: Nguyen
authors.forename: A
authors.initials: A
authors.lastname: Chi
authors.forename: L M
authors.initials: LM
authors.lastname: Nguyen
authors.forename: B H
authors.initials: BH
authors.lastname: Ly
authors.forename: U
authors.initials: U
authors.lastname: Karlsson
authors.forename: V
authors.initials: V
authors.lastname: Vinh-Hung
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D052162:Human papillomavirus 16 / Q000235:genetics; D006801:Humans; D008297:Male; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology / Q000628:therapy / Q000821:virology*; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000628:therapy / Q000821:virology*; D055815:Young Adult
chemical_list: D004279:DNA, Viral