title: A new definition of early age at onset in alcohol dependence.
abstract: OBJECTIVE
  The accurate cut-off of an early onset of alcohol dependence is unknown. The objectives of this analysis are (1) to confirm that ages at onset variability in alcohol dependence is best described as a two subgroups entity, (2) to define the most appropriate cut-off, and (3) to test the relevancy of such distinction.
  
  
  METHODS
  Data were drawn the Epidemiologic Survey on Alcohol and Related Conditions (NESARC). This study focused on the 4782 adults with lifetime alcohol dependence.
  
  
  RESULTS
  The best-fit model distinguished two subgroups of age at onset of alcohol dependence, with a cut-off point at 22 years. Subjects with an earlier onset of alcohol dependence (< or = 22 years old) reported higher lifetime rates of specific phobia, antisocial behaviors and nearly all addictive disorders.
  
  
  CONCLUSIONS
  The early onset of alcohol dependence is best defined as beginning before the age of 22 years.
authors.affiliation: INSERM U894/U675, Centre Psychiatrie et Neurosciences, 75014 Paris, France. yann.lestrat@inserm.fr
authors.forename: Yann
authors.initials: Y
authors.lastname: Le Strat
authors.forename: Bridget F
authors.initials: BF
authors.lastname: Grant
authors.forename: Nicolas
authors.initials: N
authors.lastname: Ramoz
authors.forename: Philip
authors.initials: P
authors.lastname: Gorwood
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000437:Alcoholism / Q000453:epidemiology*; D000987:Antisocial Personality Disorder / Q000453:epidemiology / Q000523:psychology; D015897:Comorbidity; D004493:Education; D005006:Ethnicity; D005260:Female; D006801:Humans; D007182:Income; D008297:Male; D017533:Marital Status; D001523:Mental Disorders / Q000150:complications / Q000453:epidemiology; D008875:Middle Aged; D016017:Odds Ratio; D011569:Psychiatric Status Rating Scales; D012737:Sex Factors; D012959:Socioeconomic Factors; D019966:Substance-Related Disorders / Q000453:epidemiology; D009626:Terminology as Topic; D014481:United States / Q000453:epidemiology; D014505:Urban Population; D055815:Young Adult