Anti-annexin A5 antibodies in women with spontaneous pregnancy loss.
OBJECTIVE
The aim was to evaluate the role of anti-annexin A5 (anti-ANXA5) antibodies as risk factor for recurrent miscarriage (RM) and unexplained fetal loss (UFL).


METHODS
Retrospective, cohort study.


METHODS
Vall d'Hebron University Hospital.


METHODS
122 women, in two groups:


METHODS
54 women with RM/UFL and control group: 68 pregnant without RM/UFL.


METHODS
Antiphospholipid, mainly anti-ANXA5 antibody analysis. Comparison of all antiphospholipid antibodies between groups.


RESULTS
Antiphospholipid antibody (aPL) prevalence in the study group was 10/54 (14.8%) and 5/68 (7.3%) in control group (p=0.09). In the RM subgroup, it was 3/25 and 9/34 in UFL versus 5/68 in controls (p=0.013). Lupus anticoagulant (LA) was present in 4 cases, all belonging to the study group (p=0.011). Four out of 34 women with UFL were positive for anticardiolipin antibodies-IgG (IgG-aCL) versus 1/68 in controls (p=0.041). In RM subgroup, anti-ANXA5 antibodies were positive in 2/25 versus 3/68 in controls, and in UFL subgroup, 3/34 versus 3/68 cases (p=1.000).


CONCLUSIONS
According to our results, anti-ANXA5 antibodies should not be considered as a risk factor for RM/UFL.
Alijotas-Reig
Jaume
J
Systemic Autoimmune Disease Unit, Department of Internal Medicine I, Hospital Universitari Vall d'Hebron, Department of Medicine, Universitat Autonoma, Barcelona, Spain. jalijotas@vhebron.net
Ferrer-Oliveras
Raquel
R
Rodrigo-Anoro
María José
MJ
Farran-Codina
Inmaculada
I
Llurba-Olivé
Elisa
E
Vilardell-Tarres
Miquel
M
Casellas-Caro
Manel
M
D000022:Abortion, Spontaneous / Q000276:immunology*; D017304:Annexin A5 / Q000276:immunology*; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D016736:Antiphospholipid Syndrome / Q000276:immunology; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D011247:Pregnancy; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors
D017304:Annexin A5; D017152:Antibodies, Antiphospholipid; D016682:Lupus Coagulation Inhibitor