title: From meiosis to postmeiotic events: the secrets of histone disappearance.
abstract: One of the most obscure phenomena in modern biology is the near genome-wide displacement of histones that occurs during the postmeiotic phases of spermatogenesis in many species. Here we review the literature to show that, during spermatogenic differentiation, three major molecular mechanisms come together to 'prepare' the nucleosomes for facilitated disassembly and histone removal.
authors.affiliation: INSERM, U823, Université Joseph Fourier, Institut Albert Bonniot, Grenoble, France.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Gaucher
authors.forename: Nicolas
authors.initials: N
authors.lastname: Reynoird
authors.forename: Emilie
authors.initials: E
authors.lastname: Montellier
authors.forename: Fayçal
authors.initials: F
authors.lastname: Boussouar
authors.forename: Sophie
authors.initials: S
authors.lastname: Rousseaux
authors.forename: Saadi
authors.initials: S
authors.lastname: Khochbin
mesh_terms: D000107:Acetylation; D000818:Animals; D002843:Chromatin / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology; D006655:Histone Deacetylases / Q000235:genetics; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008297:Male; D008540:Meiosis / Q000502:physiology*; D051379:Mice; D009707:Nucleosomes / Q000187:drug effects / Q000378:metabolism*; D011479:Protamines / Q000378:metabolism; D013087:Spermatids / Q000378:metabolism; D013091:Spermatogenesis / Q000235:genetics
chemical_list: D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; D009707:Nucleosomes; D011479:Protamines; C053886:spermatid transition proteins; D006655:Histone Deacetylases