[The pathological observation of acute intoxication by Alangium Chinese in mice].
OBJECTIVE
To investigate the pathological change of mice organ intoxicated by Alangium Chinese and its poisoning mechanism.


METHODS
Mice were intoxicated by gavage with extract of Alangium Chinese. Then the histopathologic examination was made for evaluating the pathological changes in the organs of the poisoned mice by HE staining.


RESULTS
The main pathological changes included alveolar hemorrhage, pulmonary interstitial hemorrhage, sinus hepaticus expansion and congestion, hepatocyte edema, subarachnoid hemorrhage, congestion and hemorrhage of other organs.


CONCLUSIONS
The main target organs or tissue of Alangium Chinese are the lungs, liver and vascular smooth muscle. There is correlation between the toxic effect and the dosage.
Zhang
Chang-Yin
CY
Chizhou Qiucheng Forensic Judical Appraisal Institute, Chizhou, China.
Zhang
Li-Jun
LJ
Hu
Yong-Liang
YL
Xia
Xian-Dong
XD
Lu
Lin-Ming
LM
Yan
Yi-Feng
YF
Xu
Xiang
X
Ke
Wei
W
Zhu
Jian-Hua
JH
D000208:Acute Disease; D032604:Alangiaceae / Q000737:chemistry*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D049429:Forensic Pathology; D006470:Hemorrhage / Q000209:etiology / Q000473:pathology; D022781:Hepatocytes / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D018517:Plant Roots / Q000737:chemistry; D011897:Random Allocation; D023382:Toxicity Tests, Acute
D010936:Plant Extracts