[Can extended induction chemoradiotherapy be effective in the combined treatment of stage IIIB Hodgkin's disease ?].
The paper evaluates the results of chemoradiaton (2-4 cycles of preliminary treatment to suppress intoxication symptoms plus total, or subtotal exposure of the lymph nodes to tumor-killing doses in cases of intact iliac inguinal nodes) in 89 patients with Hodgkin's disease stage IIIB. The data are evaluated vis-à-vis regression in exposed foci as intoxication symptoms receded. Overall survival was significantly lower (p = 0.044) when tumor regression was well below 75%. Similar trends were reported with regard to relapse-free survival. It is concluded that, with our regimen, combined treatment will not be effective unless 75% or more regression of tumor is assured.
Kanaev
S V
SV
Girshovich
M M
MM
Golovanov
S G
SG
Gershanovich
M L
ML
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant / Q000379:methods; D018572:Disease-Free Survival; D004334:Drug Administration Schedule; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant / Q000379:methods; D012074:Remission Induction / Q000379:methods; D016896:Treatment Outcome