title: Management of osteomyelitis of the foot in diabetes mellitus.
abstract: Although osteomyelitis occurs in approximately 10-20% of patients with diabetes-related foot ulcers, no widely accepted guideline is available for its treatment. In particular, little consensus exists on the place of surgery. A number of experts claim that early surgical excision of all infected or necrotic bone is essential. Others suggest that surgery should not be performed routinely, but instead only in patients who do not respond to antibiotic treatment or in case of particular clinical indications. Unfortunately, no studies have directly compared the two approaches. Over 500 cases of conservative (that is, nonsurgical) management with resolution rates of 60-80% have been described previously. Most patients in these series, however, received prolonged courses of broad-spectrum antibiotics, which increase the risk of diarrhea caused by Clostridium difficile or the emergence of multidrug-resistant organisms. By contrast, relatively few series of primarily surgical management have been published, with widely differing outcomes, and some of them also reported high recurrence rates. Further research is required to establish the relative importance of each approach, but the available data clearly indicate that a combined assessment and treatment by surgeons and physicians together is essential for many patients.
authors.affiliation: Foot Ulcer Trials Unit, Nottingham University Hospitals NHS Trust, City campus, Hucknall Road, Nottingham NG5 1PB, UK. fgame@futu.co.uk
authors.forename: Fran
authors.initials: F
authors.lastname: Game
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001706:Biopsy; D017719:Diabetic Foot / Q000473:pathology / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D006801:Humans; D010019:Osteomyelitis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents