title: Factors associated with impaired urinary albumin excretion in hypertensive individuals: albuminuria and hypertension.
abstract: Albuminuria is well established as a cardiovascular and renal risk factor. This study aimed to analyze factors associated with this condition in 267 hypertensive individuals, stratified according to urinary albumin excretion (UAE) as: G1--130 individuals with normoalbuminuria (24-h UAE<20 μg/min); G2--113 with microalbuminuria (UAE between 20 and 200 μg/min); and G3--24 with macroalbuminuria (UAE≥200 μg/min). There were significant differences among the groups for blood pressure levels, left ventricular mass and index, estimated glomerular filtration rate, serum creatinine, renal dysfunction and diabetes mellitus (p<0.05). Macroalbuminuria was associated with renal dysfunction (OR=5.91; 95% CI: 2.44-14.31; p<0.001) and microalbuminuria with LVH (OR=2.21; 95% CI: 1.27-3.85; p=0.005). The association between UAE with blood pressure levels, diabetes and target-organ damage in hypertensive individuals suggests that adequate control of cardiovascular risk factors should be pursued to decrease morbidity associated with these conditions.
authors.affiliation: Hypertension Clinic, Department of Internal Medicine, State Medical School of São José do Rio Preto/SP (FAMERP), Brazil. Electronic address: renanovmelo@gmail.com.
authors.forename: Renan Oliveira Vaz
authors.initials: ROV
authors.lastname: de Melo
authors.affiliation: Hypertension Clinic, Department of Internal Medicine, State Medical School of São José do Rio Preto/SP (FAMERP), Brazil.
authors.forename: Juan Carlos Yugar
authors.initials: JCY
authors.lastname: Toledo
authors.affiliation: Molecular Biology Department, State Medical School of São José do Rio Preto/SP (FAMERP), Brazil.
authors.forename: Dorotéia Rossi Silva
authors.initials: DRS
authors.lastname: Souza
authors.affiliation: Hypertension Clinic, Department of Internal Medicine, State Medical School of São José do Rio Preto/SP (FAMERP), Brazil.
authors.forename: José Fernando Vilela
authors.initials: JFV
authors.lastname: Martin
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000150:complications* / Q000175:diagnosis / Q000652:urine*; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000652:urine; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis / Q000652:urine*; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000652:urine; D008297:Male; D008875:Middle Aged