title: Theoretical and experimental evaluation of continuous arterial spin labeling techniques.
abstract: Continuous arterial spin labeling is known to be the most sensitive arterial spin labeling technique. To avoid magnetization transfer effects and to overcome hardware limitations, several sequences have been proposed that adiabatically label the inflowing blood. Four of these methods are examined with respect to their sensitivity both theoretically by Bloch equation simulations and experimentally. All sequences were optimized carefully by adjusting their measurement parameters based exclusively on the results of simulations. Perfusion measurements on the human brain obtained at 3 T result in excellent images from all techniques, while differences in sensitivity are similar to those expected from the simulations.
authors.affiliation: Max Planck Institute for Biological Cybernetics, Magnetic Resonance Center, Tübingen, Germany. Rolf.Pohmann@tuebingen.mpg.de
authors.forename: Rolf
authors.initials: R
authors.lastname: Pohmann
authors.forename: Juliane
authors.initials: J
authors.lastname: Budde
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Auerbach
authors.forename: Gregor
authors.initials: G
authors.lastname: Adriany
authors.forename: Kâmil
authors.initials: K
authors.lastname: Uğurbil
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology*; D002339:Carotid Arteries / Q000033:anatomy & histology* / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels
chemical_list: D013113:Spin Labels