Matricellular proteins and inflammatory cells: a task force to promote or defeat cancer?
In the last years it became clear that the tumor microenvironment plays a major role in neoplastic growth. Proteins secreted either by the malignant cells or by the tumor-associated stromal cells act as extracellular signal transductors, orchestrating tumor progression. Sentinel cells of the innate immune system patrol the different organs and have proven either to promote tumor growth or induce tumor suppression. In recent years, members of the matricellular family of extracellular proteins were shown to be involved in different aspects of the inflammatory response during tumor development, although in contradictory ways. In this review we discuss the evidence available up to date that relates matricellular proteins with the regulation of the inflammatory response and tumor progression.
Llera
Andrea Sabina
AS
Laboratory of Molecular and Cellular Therapy, Fundacion Instituto Leloir, University of Buenos Aires, National Council for Scientific and Technological Research (CONICET), Buenos Aires, Argentina.
Girotti
Maria Romina
MR
Benedetti
Lorena Gabriela
LG
Podhajcer
Osvaldo Luis
OL
D000818:Animals; D018925:Chemokines / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D016326:Extracellular Matrix Proteins / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000150:complications* / Q000276:immunology*; D018448:Models, Immunological; D009369:Neoplasms / Q000209:etiology* / Q000276:immunology* / Q000517:prevention & control; D015676:Osteonectin / Q000276:immunology; D014945:Wound Healing / Q000276:immunology
D018925:Chemokines; D016207:Cytokines; D016326:Extracellular Matrix Proteins; D015676:Osteonectin