title: Continuous infusion of 17-hydroxyprogesterone caproate into either the fetoplacental or intervillous circulation of a placental cotyledon attenuates vasoconstriction of the fetoplacental arteries by thromboxane mimetic U46619.
abstract: OBJECTIVE
  The objective of the study was to determine whether pretreatment of fetal or maternal placental vasculature with 17-hydroxyprogesterone caproate (17-P) attenuates the vasoactive effect of the thromboxane mimetic U46619.
  
  
  METHODS
  Two cotyledons were obtained from each placenta studied. For the first 5 placentas, the fetal artery of 1 cotyledon from each pair was infused with 17-P. After 30 minutes, a bolus dose of U46619 was administered to both cotyledons. An identical procedure was carried out on the next 5 placentas except that 17-P was infused into the intervillous space.
  
  
  RESULTS
  The pressure excursion caused by bolus administration of U46619 was less in the cotyledons infused with 17-P, both in the 5 cases in which the fetal vasculature was infused with 17-P (P = .0035) and in the 5 cases in which the maternal vasculature was infused with 17-P (P = .038).
  
  
  CONCLUSIONS
  Pretreatment of either the fetal or maternal circuits of the placenta with 17-P attenuates U46619-mediated fetoplacental vasoconstriction.
authors.affiliation: Department of Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, WA, USA. craig.zelig@amedd.army.mil
authors.forename: Craig M
authors.initials: CM
authors.lastname: Zelig
authors.forename: Damian J
authors.initials: DJ
authors.lastname: Paonessa
authors.forename: Nathan J
authors.initials: NJ
authors.lastname: Hoeldtke
authors.forename: Demetrice L
authors.initials: DL
authors.lastname: Hill
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Foglia
authors.forename: Peter G
authors.initials: PG
authors.lastname: Napolitano
mesh_terms: D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / Q000494:pharmacology*; D000077713:17 alpha-Hydroxyprogesterone Caproate; D001158:Arteries / Q000187:drug effects / Q000502:physiology; D005260:Female; D005333:Fetus / Q000098:blood supply / Q000187:drug effects*; D006801:Humans; D006908:Hydroxyprogesterones / Q000494:pharmacology*; D010920:Placenta / Q000098:blood supply / Q000187:drug effects*; D011247:Pregnancy; D012039:Regional Blood Flow / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D006908:Hydroxyprogesterones; D000077713:17 alpha-Hydroxyprogesterone Caproate; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid