title: Effects of levetiracetam and valproic acid monotherapy on sex-steroid hormones in prepubertal children--results from a pilot study.
abstract: The influence of levetiracetam (LEV) and valproic acid (VPA) monotherapy on sex-steroid hormone profile was investigated in thirty prepubertal children. VPA-treated children showed greatest androstendione concentrations when compared to LEV treated children (p=0.016) and to controls (p=0.011). All other reproductive endocrine hormones were similar among groups. In conclusion, LEV does not seem to induce changes in reproductive endocrine functions as well as clinically relevant endocrine side effects in prepubertal children.
authors.affiliation: Department of Paediatrics IV, Division of Neuropediatrics, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Markus
authors.initials: M
authors.lastname: Rauchenzauner
authors.forename: Gabriele
authors.initials: G
authors.lastname: Bitsche
authors.forename: Sigrid
authors.initials: S
authors.lastname: Svalheim
authors.forename: Erik
authors.initials: E
authors.lastname: Tauboll
authors.forename: Edda
authors.initials: E
authors.lastname: Haberlandt
authors.forename: Ludwig
authors.initials: L
authors.lastname: Wildt
authors.forename: Kevin
authors.initials: K
authors.lastname: Rostasy
authors.forename: Gerhard
authors.initials: G
authors.lastname: Luef
mesh_terms: D000704:Analysis of Variance; D000927:Anticonvulsants / Q000009:adverse effects; D002648:Child; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006801:Humans; D000077287:Levetiracetam; D008297:Male; D010865:Pilot Projects; D010889:Piracetam / Q000009:adverse effects / Q000031:analogs & derivatives*; D012737:Sex Factors; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary; D000077287:Levetiracetam; D014635:Valproic Acid; D010889:Piracetam