[Effects of Qingshi Cream on chronic dermatitis-eczema in mice].
OBJECTIVE
To explore the effects of Qingshi Cream, a compound traditional Chinese herbal medicine, on chronic dermatitis-eczema in mice induced by 2,4-dinitrochlorobenzene (DNCB).


METHODS
Thirty BALB/C mice were randomly divided into vaseline group, 0.1% mometasone furoate cream group and Qingshi Cream group. Right ears of BALB/C mice were repeatedly challenged with 0.1% DNCB every three days for five times and previously sensitized with 7% DNCB to induce chronic dermatitis-eczema. Mice in different groups were applied Qingshi Cream, 0.1% mometasone furoate cream and vaseline respectively after each challenge. Weight difference of two ears, pathological change of right ear and dermal inflammatory cell number were used to assess the effects of the drugs.


RESULTS
After the 5th challenge, weight differences of two ears in the 0.1% mometasone furoate cream group and the Qingshi Cream group were significantly decreased as compared with that in the vaseline group. Changes such as ear swelling thickening and cellular infiltration in dermis were observed, and these features seemed to be more significant in the vaseline group as compared with the 0.1% mometasone furoate cream group and the Qingshi Cream group.


CONCLUSIONS
Qingshi Cream has an obvious effect in treatment of chronic dermatitis-eczema in mice.
Li
Yong-mei
YM
Department of Dermatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. liyongmei2006@126.com
Li
Xiao-rui
XR
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004485:Eczema / Q000188:drug therapy*; D008516:Medicine, Chinese Traditional; D051379:Mice; D008807:Mice, Inbred BALB C; D000068656:Mometasone Furoate / Q000627:therapeutic use*; D011897:Random Allocation
D000893:Anti-Inflammatory Agents; D000068656:Mometasone Furoate