title: A bioactive isoprenylated xanthone and other constituents of Garcinia edulis.
abstract: Phytochemical investigation on the root bark of Garcinia edulis (Clusiaceae) gave a new isoprenylated xanthone, 1,4,6-trihydroxy-3-methoxy-2-(3-methyl-2-butenyl)-5-(1,1-dimethyl-prop-2-enyl)xanthone (1), a known xanthone, forbexanthone (2) together with three known pentacyclic triterpenoids, friedelin, lupeol and lupeol acetate. The structure of the new compound was fully characterised by NMR spectroscopic analysis. Compound 1 showed significant anti-HIV-1 protease activity with IC(50) value of 11.3 microg/mL. Furthermore, compound 1 showed potent cytotoxic activity with LC(50) value of 2.36 microg/mL against brine shrimp larva in vitro.
authors.affiliation: Department of Natural Product Development and Formulations, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. magadulajanguj@yahoo.com
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Magadula
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects*; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029760:Garcinia / Q000737:chemistry*; D017320:HIV Protease Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015497:HIV-1; D007814:Larva / Q000187:drug effects; D015394:Molecular Structure; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots; D014315:Triterpenes / Q000302:isolation & purification; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C554250:1,4,6-trihydroxy-3-methoxy-2-(3-methyl-2-butenyl)-5-(1,1-dimethyl-prop-2-enyl)xanthone; D003603:Cytotoxins; D017320:HIV Protease Inhibitors; D010936:Plant Extracts; D014315:Triterpenes; D044004:Xanthones; C009689:xanthone