Mechanochemical crosstalk during endocytic vesicle formation.
Membrane curvature has emerged as a key regulatory factor in endocytic vesicle formation. From a theoretical perspective, we summarize recent progress in understanding how membrane curvature and biochemical pathways are coupled and orchestrated during the coherent process of endocytic vesicle formation. We mainly focus on clathrin-mediated and actin-mediated endocytosis in yeast and in mammalian cells. We further speculate on how mechanochemical feedback could modulate other membrane-remodeling processes.
Liu
Jian
J
Department of Molecular and Cell Biology, UC-Berkeley, United States.
Sun
Yidi
Y
Oster
George F
GF
Drubin
David G
DG
D000199:Actins / Q000378:metabolism; D000818:Animals; D002966:Clathrin / Q000378:metabolism; D034281:Dynamins / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D022161:Transport Vesicles / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure
D000199:Actins; D002966:Clathrin; D008051:Lipid Bilayers; D034281:Dynamins