Plant PRA plays an important role in intracellular vesicular trafficking between compartments as GDF.
Rab GTPases like Ras-related monomeric GTPases are well known to regulate intracellular vesicle trafficking by cycling between membrane-bound and cytosolic states. The functions of these proteins are controlled by upstream regulators and downstream effectors. Ypt/Rabs transmit signals to downstream effectors in a GTP-dependent manner. GDP-bound Rab proteins are extracted from their target membrane by cytosolic proteins known as GDP dissociation inhibitors (GDIs), and the Rab GTPase is recruited to the membrane compartment following dissociation from the GDI by GDI displacement factor (GDF). Now, we're going to discuss the role of plant PRA concerted with Rab and GDI proteins by recycling Rab between membrane and cytosol for intracellular trafficking of cargo proteins.
Bahk
Jeong Dong
JD
Division of Applied Life Science (BK21-EBNCRC), Graduate School of Gyeongsang National University, Jinju, Korea. jdbahk@gnu.ac.kr
Bang
Woo Young
WY
Heo
Jae Bok
JB
D020730:Guanine Nucleotide Dissociation Inhibitors / Q000378:metabolism*; D006801:Humans; D012275:Oryza / Q000378:metabolism*; D022161:Transport Vesicles / Q000378:metabolism*; D033921:Vesicular Transport Proteins / Q000378:metabolism*; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
D020730:Guanine Nucleotide Dissociation Inhibitors; D033921:Vesicular Transport Proteins; D020691:rab GTP-Binding Proteins