title: Effect of implanting fibrin sealant with ropivacaine on pain after laparoscopic cholecystectomy.
abstract: OBJECTIVE
  To investigate the safety and efficacy of implanting fibrin sealant with sustained-release ropivacaine in the gallbladder bed for pain after laparoscopic cholecystectomy (LC).
  
  
  METHODS
  Sixty patients (American Society of Anesthesiologists physical status was I or II and underwent LC) were randomly divided into three equal groups: group A (implantation of fibrin sealant in the gallbladder bed), group B (implantation of fibrin sealant carrying ropivacaine in the gallbladder bed), and group C (normal saline in the gallbladder bed). Postoperative pain was evaluated, and pain relief was assessed by visual analog scale (VAS) scoring.
  
  
  RESULTS
  The findings showed that 81.7% of patients had visceral pain, 50% experienced parietal, and 26.7% reported shoulder pain after LC. Visceral pain was significantly less in group B patients than in the other groups (P < 0.05), and only one patient in this group experienced shoulder pain. The mean VAS score in group B patients was lower than that in the other groups.
  
  
  CONCLUSIONS
  Visceral pain is prominent after LC and can be effectively controlled by implanting fibrin sealant combined with ropivacaine in the gallbladder bed.
authors.affiliation: Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Jian-Zhu
authors.initials: JZ
authors.lastname: Fu
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Ze-Li
authors.initials: ZL
authors.lastname: Yu
mesh_terms: D000328:Adult; D000577:Amides / Q000627:therapeutic use*; D000779:Anesthetics, Local / Q000627:therapeutic use*; D017081:Cholecystectomy, Laparoscopic / Q000379:methods*; D003692:Delayed-Action Preparations; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D000077212:Ropivacaine
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D003692:Delayed-Action Preparations; D015718:Fibrin Tissue Adhesive; D000077212:Ropivacaine