title: Long-term complete regression of nodal marginal zone lymphoma transformed into diffuse large B-cell lymphoma with highly active antiretroviral therapy alone in human immunodeficiency virus infection.
abstract: Since the introduction of combination antiretroviral therapy (cART), there has been a decrease in the incidence of non-Hodgkin lymphoma among the HIV-infected population and also significantly improved survival rates. We describe a remarkable case of a HIV-infected patient whose large B-cell lymphoma, most likely arising by transformation of a nodal marginal zone lymphoma, completely regressed with the use of cART alone. He remained disease-free for almost 3 years and he finally died from presumed flare up of his lymphoma. There are very few cases of spontaneous regression of lymphomas with cART alone in the HIV population. This is an extreme example of the significance of cART in improving survival in HIV-non-Hodgkin lymphoma and changing the face of the HIV epidemic in general.
authors.affiliation: Infectious Diseases & HIV Division, 5th Department of Internal Medicine, Evaggelismos General Hospital, Athens, Greece. ioannisbaraboutis@yahoo.gr
authors.forename: Ioannis G
authors.initials: IG
authors.lastname: Baraboutis
authors.forename: Leonidas
authors.initials: L
authors.lastname: Marinos
authors.forename: Lazaros J
authors.initials: LJ
authors.lastname: Lekakis
authors.forename: Vasilios
authors.initials: V
authors.lastname: Papastamopoulos
authors.forename: Ourania
authors.initials: O
authors.lastname: Georgiou
authors.forename: Eleftheria P
authors.initials: EP
authors.lastname: Tsagalou
authors.forename: Phoeve
authors.initials: P
authors.lastname: Rondogianni
authors.forename: John
authors.initials: J
authors.lastname: Apostolidis
authors.forename: Theodora
authors.initials: T
authors.lastname: Papadaki
authors.forename: Athanasios T
authors.initials: AT
authors.lastname: Skoutelis
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000188:drug therapy* / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D013997:Time Factors