Malignant peripheral nerve sheath tumor of the uterine cervix expressing both S-100 protein and HMB-45.
A 50-year-old woman presented with a large cervical polypoid mass. Grossly, the mass occupied a substantial proportion of the cervical canal, measuring 6 cm. Histologically, the mass showed a spindle cell malignancy arranged in large fascicles that penetrated deeply into the fibromuscular wall of the cervix. The spindle cells were immunoreactive for both S-100 protein and HMB-45 antigen, but were negative for Melan-A. Electron microscopy showed that cytoplasmic processes of the spindle to oval tumor cells contained microtubules and were lined by basal lamina and abundant intercellular collagen spacing with no melanosomes in any stage. As far as we are aware, this is the ninth reported case of cervical malignant peripheral nerve sheath tumor (MPNST), and the second reported case of MPNST expressing HMB-45 antigen.
Kim
Na Rae
NR
Department of Pathology, Gachon University of Medicine and Science, Gil Medical Center, Incheon, Korea.
Chung
Dong-Hae
DH
Park
Chan Yong
CY
Ha
Seung Yeon
SY
D000951:Antigens, Neoplasm / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D058950:Melanoma-Specific Antigens; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D018317:Nerve Sheath Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000556:secondary / Q000601:surgery / Q000648:ultrastructure; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000556:secondary*; D009418:S100 Proteins / Q000096:biosynthesis*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000601:surgery
D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D009418:S100 Proteins