Immune responses to Epstein-Barr virus: molecular interactions in the virus evasion of CD8+ T cell immunity.
Persistent viruses have mechanisms for modulating the host immune responses that are essential for achieving a lifelong virus-host balance while minimizing the viral pathogenicity. Here we review some of the immune-modulating mechanisms evolved by the ubiquitous but potentially oncogenic Epstein-Barr virus, with particular emphasis on the molecular mechanisms of genes interfering with HLA class I antigen presentation.
Rowe
Martin
M
Cancer Research UK Birmingham Cancer Centre, University of Birmingham, College of Medical and Dental Sciences, Vincent Drive, Edgbaston, Birmingham B15 2TT, United Kingdom. m.rowe@bham.ac.uk
Zuo
Jianmin
J
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000276:immunology* / Q000472:pathogenicity*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans
D015395:Histocompatibility Antigens Class I