Adverse drug reactions affecting blood cells.
Numerous medications and other xenobiotics are capable of producing adverse reactions (ADRs) affecting red cells, platelets or neutrophils. Occasionally, more than one blood element is affected simultaneously. As with all drug reactions, some side effects are a direct consequence of a known pharmacologic action of the drug and are dose-dependent; others occur sporadically and relatively independent of dose. The latter ("idiosyncratic") reactions are unpredictable and, in general, have no known underlying genetic basis. Many are antibody-mediated, as would be expected since cellular immune effector cells have little direct access to circulating blood cells. In this chapter, we will discuss idiosyncratic drug reactions affecting blood and blood forming tissues with an emphasis on those thought to be immune-mediated.
Aster
Richard H
RH
Blood Research Institute, Blood Center of Wisconsin, 2178 Watertown Plank Rd, Milwaukee, WI 53201, USA. richard.aster@bcw.edu
D000741:Anemia, Aplastic / Q000139:chemically induced; D000818:Animals; D001773:Blood Cells / Q000187:drug effects* / Q000276:immunology; D001792:Blood Platelets / Q000187:drug effects; D064420:Drug-Related Side Effects and Adverse Reactions; D004785:Environmental Pollutants / Q000009:adverse effects*; D004912:Erythrocytes / Q000187:drug effects; D006402:Hematologic Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D006801:Humans; D009504:Neutrophils / Q000187:drug effects
D004785:Environmental Pollutants