Daptomycin use in a neonate: serum level monitoring and outcome.
We present a case of successfully treated persistent bacteremia due to Gram-positive bacteria with daptomycin in a preterm neonate. Daptomycin was given at higher doses (6 mg/kg/dose) and shorter intervals (every 12 hours) than those recommended for adults with no adverse events. Peak and trough serum concentrations of daptomycin were 27.3 and 11.6 μg/mL [DOSAGE ERROR CORRECTED] at day 4 as well as 22.9 and 7.9 μg/mL [DOSAGE ERROR CORRECTED]at day 11 after initiation of treatment, respectively.
Sarafidis
Kosmas
K
1st Department of Neonatology, Aristotle University, Hippokration General Hospital, Thessaloniki, Greece.
Iosifidis
Elias
E
Gikas
Evangelos
E
Tsivitanidou
Maria
M
Drossou-Agakidou
Vassiliki
V
Roilides
Emmanuel
E
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood*; D017576:Daptomycin / Q000008:administration & dosage* / Q000097:blood*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D017576:Daptomycin