Clinicopathologic similarities between Mikulicz disease and Küttner tumor.
OBJECTIVE
Recent studies have revealed that Mikulicz disease (MD) differs from Sjögren syndrome and is an immunoglobulin G(4) (IgG(4))-related systemic disease. Küttner tumor (KT) is also reported to be an IgG(4)-related disease. In this study, we examined the clinicopathologic and serologic findings in MD (39 patients) and KT (6 patients) and attempted to discern the similarities between MD and KT.


METHODS
We diagnosed 39 patients with MD and 6 patients with KT. We analyzed the clinicopathologic and serologic findings (IgG subclasses) in 39 patients with MD and 6 patients with KT. Submandibular and labial salivary gland specimens obtained from patients with MD and KT were stained with anti-IgG(4) antibodies.


RESULTS
The mean IgG(4) concentration (±SD) was 931.1 ± 796.2 mg/dL in patients with MD and 756.2 ± 449.2 mg/dL in patients with KT. Abundant infiltration of IgG(4)-positive plasmacytes into the salivary glands was observed in both patients with MD and patients with KT.


CONCLUSIONS
The serologic and histopathologic findings in MD and KT are very similar, and these 2 conditions may be IgG(4)-related systemic diseases.
Takano
Ken-ichi
K
Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan. k-takano@v7.com
Yamamoto
Motohisa
M
Takahashi
Hiroki
H
Shinomura
Yasuhisa
Y
Imai
Kohzoh
K
Himi
Tetsuo
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D008882:Mikulicz' Disease / Q000276:immunology* / Q000473:pathology*; D010950:Plasma Cells / Q000276:immunology; D012469:Salivary Glands / Q000276:immunology; D012793:Sialadenitis / Q000276:immunology* / Q000473:pathology*; D013363:Submandibular Gland / Q000276:immunology; D013364:Submandibular Gland Diseases / Q000276:immunology* / Q000473:pathology*
D007074:Immunoglobulin G