Pinpointing Pin1 in non-small cell lung carcinoma.
Factors that promote tumorigenesis encompass a wide array of proteins that include transcription factors, signal transduction molecules, negative regulators of tumor suppressors, transmembrane receptors and enzymes involved in a variety of processes. Identifying these factors remains one of the most pertinent issues in cancer research, as they can be used as both diagnostic markers and therapeutic targets. The ability to characterize tumors based on molecular markers will enable one to easily assess tumor severity, select a method of treatment and ultimately improve patient outcome. While the treatment of primary tumors has improved by leaps and bounds over the past decade, metastases continue to plague both patients and the research community. Along these lines, markers that predict metastatic potential will help to both limit secondary tumor growths and improve patient outcome.
Catanzaro
Joseph
J
Graduate Program in Genetics, Stony Brook University, Stony Brook, NY, USA.
Zong
Wei-Xing
WX
D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D054337:Cell Dedifferentiation / Q000502:physiology; D002455:Cell Division; D045744:Cell Line, Tumor / Q000378:metabolism / Q000637:transplantation; D002471:Cell Transformation, Neoplastic; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D051379:Mice; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D009368:Neoplasm Transplantation; D019696:Peptidylprolyl Isomerase / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D011379:Prognosis; D014410:Tumor Stem Cell Assay
D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D009363:Neoplasm Proteins; C000606846:PIN1 protein, human; D019696:Peptidylprolyl Isomerase; C000606850:Pin1 protein, mouse