title: Association of human micro-opioid receptor gene polymorphism A118G with fentanyl analgesia consumption in Chinese gynaecological patients.
abstract: One hundred and seventy-four Chinese gynaecology patients were studied for the impact of A118G polymorphism in the micro-opioid receptor gene (OPRM1) on pain sensitivity and postoperative fentanyl consumption. Pre-operatively, the pain threshold and pain tolerance threshold were measured using electrical stimulation. A118G polymorphism was genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. Intravenous fentanyl patient-controlled analgesia provided postoperative pain management, assessed using a visual analogue scale and fentanyl consumed in the first 24 h after surgery was noted. We found the prevalence of G118 allele was 31.3%. The A118G polymorphism had a gene-dose-dependent effect on electrical pain tolerance threshold. Fentanyl consumption was also significantly different in patients with different OPRM1 genotypes (homozygotes for 118G consumed more than did heterozygotes or homozygotes for 118A). Fentanyl consumption increased in accordance with the number of 118G alleles. We conclude that OPRM1 gene analysis may help predict individual opioid sensitivity and so optimise postoperative pain control.
authors.affiliation: Department of Anaesthesiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Chang
authors.forename: Q C
authors.initials: QC
authors.lastname: Kan
authors.forename: L R
authors.initials: LR
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Lu
authors.forename: Q J
authors.initials: QJ
authors.lastname: Chu
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Wang
authors.forename: Z S
authors.initials: ZS
authors.lastname: Li
authors.forename: J
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D016058:Analgesia, Patient-Controlled / Q000379:methods; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D044466:Asian People / Q000235:genetics*; D004558:Electric Stimulation; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000601:surgery; D008875:Middle Aged; D010147:Pain Measurement / Q000379:methods; D017288:Pain Threshold / Q000208:ethnology; D010149:Postoperative Pain / Q000235:genetics* / Q000517:prevention & control; D016133:Polymerase Chain Reaction / Q000379:methods; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D017450:Receptors, Opioid, mu / Q000235:genetics*; D014594:Uterine Neoplasms / Q000601:surgery; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; C485764:OPRM1 protein, human; D017450:Receptors, Opioid, mu; D005283:Fentanyl