title: Spontaneous and reversible self-assembly of a polypeptide fragment of insulin-like growth factor binding protein-2 into fluorescent nanotubular structures.
abstract: In this communication, we report the spontaneous and reversible in vitro self-assembly of a polypeptide fragment derived from the C-terminal domain of Insulin-like Growth Factor Binding Protein (IGFBP-2) into soluble nanotubular structures several micrometres long via a mechanism involving inter-molecular disulfide bonds and exhibiting enhanced fluorescence.
authors.affiliation: NMR Research Centre, Indian Institute of Science, Bangalore-560012, India.
authors.forename: Monalisa
authors.initials: M
authors.lastname: Swain
authors.forename: R
authors.initials: R
authors.lastname: Thirupathi
authors.forename: B
authors.initials: B
authors.lastname: Krishnarjuna
authors.forename: Erin M
authors.initials: EM
authors.lastname: Eaton
authors.forename: Megan M
authors.initials: MM
authors.lastname: Kibbey
authors.forename: Steven A
authors.initials: SA
authors.lastname: Rosenzweig
authors.forename: Hanudatta S
authors.initials: HS
authors.lastname: Atreya
mesh_terms: D019943:Amino Acid Substitution; D005456:Fluorescent Dyes / Q000737:chemistry*; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008856:Microscopy, Fluorescence; D016297:Mutagenesis, Site-Directed; D043942:Nanotubes / Q000737:chemistry*; D017510:Protein Folding
chemical_list: D005456:Fluorescent Dyes; D018971:Insulin-Like Growth Factor Binding Protein 2