title: Penicillin-binding proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes.
abstract: While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem.
authors.affiliation: Unité de pharmacologie cellulaire et moléculaire, Université catholique de Louvain, Bruxelles, Belgium. sebastien.vandevelde@uclouvain.be
authors.forename: Sébastien
authors.initials: S
authors.lastname: Van de Velde
authors.forename: Stéphane
authors.initials: S
authors.lastname: Carryn
authors.forename: Françoise
authors.initials: F
authors.lastname: Van Bambeke
authors.forename: Colin
authors.initials: C
authors.lastname: Hill
authors.forename: Paul M
authors.initials: PM
authors.lastname: Tulkens
authors.forename: Roy D
authors.initials: RD
authors.lastname: Sleator