title: Relation of the expression of transcriptional factor TFAP2B to that of adipokines in subcutaneous and omental adipose tissues.
abstract: To determine the potential role of the transcriptional factor-activating enhancer-binding protein-2beta (TFAP2B) in the regulation of expression of adipokines, adiponectin, leptin, and interleukin-6 (IL-6) in vivo, we quantified the mRNA expression levels of these adipokines and TFAP2B in visceral (omental) and abdominal subcutaneous adipose tissues of 66 individuals with variable degree of adiposity and studied their correlations with BMI and their plasma concentrations. We found that BMI correlated negatively with plasma adiponectin levels and positively with those of leptin. Adiponection mRNA expression in subcutaneous fat correlated negatively with BMI, whereas leptin mRNA levels in the omentum correlated with plasma leptin levels and BMI. In contrast, IL-6 mRNA levels in subcutaneous and omental fat did not correlate with BMI. IL-6 mRNA levels in the omental fat correlated with plasma IL-6 levels. Whereas TFAP2B mRNA expression did not correlate with BMI, it correlated negatively with adiponectin expression in the subcutaneous adipose tissue. Furthermore, TFAP2B mRNA expression correlated negatively with leptin and positively with IL-6 expression in both subcutaneous and omental adipose tissues. These relationships are consistent with our in vitro observations and indicate that TFAP2B seems to regulate the expression of various adipokines in vivo.
authors.affiliation: Department of Medicine, Shiga University of Medical Science, Shiga, Japan. sugi@belle.shiga-med.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ugi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Nishio
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ikeda
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Shuichi
authors.initials: S
authors.lastname: Tsukada
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Kondo
authors.forename: Katsutaro
authors.initials: K
authors.lastname: Morino
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Obata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshizaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Uzu
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Naitoh
authors.forename: Toru
authors.initials: T
authors.lastname: Tani
authors.forename: Shiro
authors.initials: S
authors.lastname: Maeda
authors.forename: Atsunori
authors.initials: A
authors.lastname: Kashiwagi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maegawa
mesh_terms: D050153:Abdominal Fat / Q000502:physiology; D052242:Adiponectin / Q000097:blood / Q000235:genetics; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics; D020738:Leptin / Q000097:blood / Q000235:genetics*; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D009852:Omentum / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism; D050151:Subcutaneous Fat / Q000502:physiology*; D050656:Transcription Factor AP-2 / Q000235:genetics* / Q000378:metabolism
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; C508600:IL6 protein, human; D015850:Interleukin-6; D020738:Leptin; D012333:RNA, Messenger; C493677:TFAP2B protein, human; D050656:Transcription Factor AP-2