title: Relevance of the CX3CL1/fractalkine-CX3CR1 pathway in vasculitis and vasculopathy.
abstract: The clinical presentation of systemic vasculitis can vary widely and include skin disorders, neuropathy, eye symptoms, and systemic inflammation. The precise molecular mechanisms underlying this syndrome are not fully understood, but the importance of a chronic imbalance of the cytokines and chemokines involved in orchestrating inflammatory responses is now recognized. In similar fashion, atherosclerosis is now recognized to be a chronic inflammatory disease in which chemokines play important roles. In the current review, we discuss the involvement of CX3CL1, which is a unique member of the chemokine family, and its receptor, CX3CR1, in the pathogenesis of these vasculopathies.
authors.affiliation: Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan. tkasama@med.showa-u.ac.jp
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kasama
authors.forename: Kuninobu
authors.initials: K
authors.lastname: Wakabayashi
authors.forename: Michihito
authors.initials: M
authors.lastname: Sato
authors.forename: Ryo
authors.initials: R
authors.lastname: Takahashi
authors.forename: Takeo
authors.initials: T
authors.lastname: Isozaki
mesh_terms: D050197:Atherosclerosis / Q000209:etiology*; D000073883:CX3C Chemokine Receptor 1; D054428:Chemokine CX3CL1 / Q000502:physiology*; D042783:Endothelial Cells / Q000502:physiology; D006801:Humans; D019707:Receptors, Chemokine / Q000032:analysis / Q000737:chemistry / Q000502:physiology*; D056647:Systemic Vasculitis / Q000209:etiology*
chemical_list: D000073883:CX3C Chemokine Receptor 1; C515538:CX3CL1 protein, human; C095235:CX3CR1 protein, human; D054428:Chemokine CX3CL1; D019707:Receptors, Chemokine