Murine model of a disseminated infection by the novel fungus Fonsecaea monophora and successful treatment with posaconazole.
We have evaluated the efficacy of posaconazole, amphotericin B, and itraconazole in a murine model of disseminated infection by Fonsecaea monophora. Of these three antifungal drugs tested, posaconazole prolonged survival significantly and reduced the fungal load in most of the organs tested. Bioassay studies demonstrated the relationship between posaconazole levels and dose escalation in serum and brain tissue. Posaconazole may have a clinical role in the treatment of disseminated infections by F. monophora.
Calvo
Enrique
E
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain.
Pastor
F Javier
FJ
Rodríguez
M Mar
MM
Mayayo
Emilio
E
Salas
Valentina
V
Guarro
Josep
J
D000818:Animals; D000935:Antifungal Agents / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D001203:Ascomycota / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D004195:Disease Models, Animal; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D008168:Lung / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D008297:Male; D051379:Mice; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D014230:Triazoles / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole