Autoimmune haemolytic anaemia associated with a thymoma: case report and review of the literature.
A 67-year-old female presents with a small mass in the anterior mediastinum on chest computed tomography. A biopsy proves the mass to be a spindle-cell-type or type A thymoma. Subsequently the patient develops fever and severe Coombs-positive haemolytic anaemia. She is initially treated with oral corticosteroids. Because of persistence of the haemolysis subsequent thymectomy is performed. Haemolysis disappears almost instantly and does not return after discontinuation of the oral corticosteroids. Review of the literature reveals only 17 other cases of thymoma-associated autoimmune haemolytic anaemia.
De Keyzer
K
K
Department of Nephrology, Ghent University Hospital, Ghent, Belgium. kristel.dekeyzer@mail.be
Peeters
P
P
Verhelst
C
C
Dendooven
A
A
Vonck
A
A
Vanholder
R
R
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D011241:Prednisone / Q000008:administration & dosage; D013934:Thymectomy; D013945:Thymoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D013953:Thymus Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery
D005938:Glucocorticoids; D011241:Prednisone