title: Botulinum toxin type A for the treatment of glabellar lines in Chinese: a double-blind, randomized, placebo-controlled study.
abstract: BACKGROUND
  This is the first well-controlled study of the use of botulinum toxin type A (BoNTA) for glabellar lines in China.
  
  
  OBJECTIVE
  To evaluate the safety and efficacy of BoNTA in the treatment of glabellar lines in Chinese subjects.
  
  
  METHODS
  A total of 227 subjects received a single treatment in a 3:1 randomization ratio of BoNTA (20 U):placebo and were observed for 120 days after injection. Effective outcome measures included investigator's rating of wrinkle severity at maximum frown and rest and subjects' global assessment and self-perception of age.
  
  
  RESULTS
  A significantly higher responder rate at maximum frown, ranging from 94.1% at day 30 to 52.9% at day 120, was noted in the BoNTA group. The proportion of subjects with none or mild glabellar lines at rest was 66.7% in the BoNTA group at day 30. Most (95.3%) of the subjects treated with BoNTA reported better than 50% improvement at day 30, and self-perception of age was less than chronological age. There were no statistically significant differences in adverse events reported between the two groups (p=.06).
  
  
  CONCLUSIONS
  A single treatment of 20 U of BoNTA was effective and safe in reducing glabellar lines in Chinese subjects.
authors.affiliation: Department of Dermatology, Peking University First Hospital, Beijing, China. adelewu@medmail.com.cn
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Guang
authors.initials: G
authors.lastname: Zhao
authors.forename: Hengjin
authors.initials: H
authors.lastname: Li
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Zheng
authors.forename: Shaomin
authors.initials: S
authors.lastname: Zhong
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Yang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Feng
authors.forename: Qinping
authors.initials: Q
authors.lastname: Yang
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000328:Adult; D044466:Asian People; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D002681:China; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D009465:Neuromuscular Agents / Q000008:administration & dosage*; D011446:Prospective Studies; D015595:Skin Aging / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A