title: New pH-dependent complexes, from mononuclear Pd(II) monomer to heteronuclear [Pd(II),K(I)]Polymer: DNA cleavage and cytotoxicity in vitro.
abstract: Two novel complexes, namely, [Pd(pdc)(2)].(dmp).6H(2)O (1) and [Pd(pdc)(2)K(H(2)O)(5).3H(2)O]n (2) [H(2)pdc=pyridine-2,3-dicarboxylate acid, dmp=2,9-Dimethyl-1,10-phenanthroline] were synthesized and characterized as pH-dependent products. Gel electrophoresis assay demonstrated the ability of the complexes to cleave the pBR 322 plasmid DNA. Values of IC(50) calculated for complexes 1 and 2 show that the two complexes exhibit good cytotoxic activity against different cell lines tested in general, especially more effective against HL-60 and A2780(cisR) cell lines.
authors.affiliation: Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang 110142, PR China. ejgao@yahoo.com.cn
authors.forename: En-Jun
authors.initials: EJ
authors.lastname: Gao
authors.forename: Ming-Chang
authors.initials: MC
authors.lastname: Zhu
authors.forename: Yun
authors.initials: Y
authors.lastname: Huang
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Liu
authors.forename: Fu-Chun
authors.initials: FC
authors.lastname: Liu
authors.forename: Shuang
authors.initials: S
authors.lastname: Ma
authors.forename: Chun-Yue
authors.initials: CY
authors.lastname: Shi
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D053837:DNA Cleavage; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D006860:Hydrogen Bonding; D006863:Hydrogen-Ion Concentration; D020128:Inhibitory Concentration 50; D046911:Macromolecular Substances; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D046911:Macromolecular Substances; D009944:Organoplatinum Compounds; D010165:Palladium