title: Highly enantioselective titanium-catalyzed cyanation of imines at room temperature.
abstract: A highly active and enantioselective titanium-catalyzed cyanation of imines at room temperature is described. The catalyst used is a partially hydrolyzed titanium alkoxide (PHTA) precatalyst together with a readily available N-salicyl-beta-aminoalcohol ligand. Up to 98% ee was obtained with quantitative yields in 15 min of reaction time using 5 mol % of the catalyst. Various N-protecting groups such as benzyl, benzhydryl, Boc, and PMP are tolerated.
authors.affiliation: Institute of Chemical and Engineering Sciences, 1 Pesek Road, Singapore 627833. abdul_seayad@ices.a-star.edu.sg
authors.forename: Abdul Majeed
authors.initials: AM
authors.lastname: Seayad
authors.forename: Balamurugan
authors.initials: B
authors.lastname: Ramalingam
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yoshinaga
authors.forename: Takushi
authors.initials: T
authors.lastname: Nagata
authors.forename: Christina L L
authors.initials: CL
authors.lastname: Chai
mesh_terms: D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature; D014025:Titanium / Q000737:chemistry*
chemical_list: D007097:Imines; D009570:Nitriles; D009942:Organometallic Compounds; D014025:Titanium