title: Malignancy-associated multicentric reticulohistiocytosis.
abstract: Multicentric reticulohistiocytosis (MR) is a rare systemic disorder of unknown etiology. Up to 25% of patients with MR have associated malignancies. We are reporting a case of a patient with MR who initially had an excellent clinical response to oral methotrexate and prednisone. Subsequent attempts of prednisone taper failed because of disease flare-up. Workup for associated malignancy revealed localized squamous cell carcinoma of the lung. The tumor was resected; methotrexate and prednisone were tapered and discontinued with complete remission of MR. A review of literature and the new advances and treatment modalities for MR is provided.
authors.affiliation: Internal Medicine Department, Kansas University School of Medicine, Wichita, KS 67206, USA.
authors.forename: Boutros
authors.initials: B
authors.lastname: El-Haddad
authors.forename: Dalia
authors.initials: D
authors.lastname: Hammoud
authors.forename: Timothy
authors.initials: T
authors.lastname: Shaver
authors.forename: Shadi
authors.initials: S
authors.lastname: Shahouri
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018771:Arthralgia / Q000175:diagnosis; D001262:Atenolol / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005221:Fatigue / Q000175:diagnosis; D005260:Female; D006225:Hand / Q000000981:diagnostic imaging / Q000473:pathology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D011241:Prednisone / Q000627:therapeutic use; D011859:Radiography; D015431:Weight Loss
chemical_list: D000959:Antihypertensive Agents; D000970:Antineoplastic Agents; D006852:Hydrochlorothiazide; D001262:Atenolol; D011241:Prednisone; D008727:Methotrexate