Neurotransmitter mechanisms of morphine withdrawal syndrome.
Activity of the major neurotransmitter systems in the brainstem and cerebellum was studied in rats with morphine withdrawal syndrome. The most significant changes were found in the brainstem of animals by the 36th hour and 7 days after morphine withdrawal. Dysfunction was revealed in the dopaminergic, noradrenergic, and serotoninergic neurotransmitter systems. Changes in cerebellar neurotransmission were most pronounced by the end of the first week of morphine withdrawal syndrome and manifested in the prevalence of inhibitory processes.
Lelevich
S V
SV
Grodno State Medical University, Belarus. slelevich@yandex.ru
Lelevich
V V
VV
Novokshonov
A A
AA
D000818:Animals; D001933:Brain Stem / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000378:metabolism; D009020:Morphine; D009021:Morphine Dependence / Q000503:physiopathology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D018377:Neurotransmitter Agents; D005680:gamma-Aminobutyric Acid; D009020:Morphine; D004298:Dopamine; D009638:Norepinephrine