New coupling strategy for radionuclide labeling of synthetic polymers.
We have developed a radiolabeling strategy for synthetic polymers based on the formation of azo dye usable for both covalent and chelating labeling modalities under mild conditions. Poly[N-(2-hydroxypropyl)methacrylamide] and poly(N-isopropyl acrylamide) were used as model polymers. N-methacryloyl tyrosinamide was introduced into the polymers and the phenolic moiety was then reacted with diazotized chelator precursors. The conjugates were radiolabeled with both the covalently bound (iodine-125) and chelated (indium-111) radionuclides in high yields and sufficient in vitro stability of the labels was proven.
Hruby
Martin
M
Institute of Macromolecular Chemistry AS CR, v.v.i., Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. mhruby@centrum.cz
Kucka
Jan
J
Novakova
Michaela
M
Mackova
Hana
H
Vetrik
Miroslav
M
D001391:Azo Compounds / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D011868:Radioisotopes / Q000737:chemistry*
D001391:Azo Compounds; D011108:Polymers; D011868:Radioisotopes