title: [The pathological observation of acute intoxication by Alangium Chinese in mice].
abstract: OBJECTIVE
  To investigate the pathological change of mice organ intoxicated by Alangium Chinese and its poisoning mechanism.
  
  
  METHODS
  Mice were intoxicated by gavage with extract of Alangium Chinese. Then the histopathologic examination was made for evaluating the pathological changes in the organs of the poisoned mice by HE staining.
  
  
  RESULTS
  The main pathological changes included alveolar hemorrhage, pulmonary interstitial hemorrhage, sinus hepaticus expansion and congestion, hepatocyte edema, subarachnoid hemorrhage, congestion and hemorrhage of other organs.
  
  
  CONCLUSIONS
  The main target organs or tissue of Alangium Chinese are the lungs, liver and vascular smooth muscle. There is correlation between the toxic effect and the dosage.
authors.affiliation: Chizhou Qiucheng Forensic Judical Appraisal Institute, Chizhou, China.
authors.forename: Chang-Yin
authors.initials: CY
authors.lastname: Zhang
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Yong-Liang
authors.initials: YL
authors.lastname: Hu
authors.forename: Xian-Dong
authors.initials: XD
authors.lastname: Xia
authors.forename: Lin-Ming
authors.initials: LM
authors.lastname: Lu
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Yan
authors.forename: Xiang
authors.initials: X
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Ke
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Zhu
mesh_terms: D000208:Acute Disease; D032604:Alangiaceae / Q000737:chemistry*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D049429:Forensic Pathology; D006470:Hemorrhage / Q000209:etiology / Q000473:pathology; D022781:Hepatocytes / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D018517:Plant Roots / Q000737:chemistry; D011897:Random Allocation; D023382:Toxicity Tests, Acute
chemical_list: D010936:Plant Extracts