Preventive effect of (-)epigallocatechin gallate on lipids, lipoproteins, and enzymes of lipid metabolism in isoproterenol-induced myocardial infarction in rats.
This article reports data on the preventive effect of (-)epigallocatechin gallate (EGCG) on lipid metabolism and lipoproteins in isoproterenol (ISO)-induced myocardial infarction (MI) in Wistar rats. The rats were induced MI by ISO (100 mg/kg) at an interval of 24 h for 2 days. EGCG (30 mg/kg) was given to rats as pretreatment for 21 days orally using an intragastric tube. EGCG significantly reduced the increased serum levels of cholesterol, triglycerides, and free fatty acids in the heart and serum phospholipids (PLs) in ISO-treated rats. It also significantly increased the reduced levels of heart PLs in ISO-induced rats. EGCG reduced the levels of serum low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol and increased serum high-density lipoprotein (HDL)-cholesterol in ISO-treated rats. It also reduced the increased cholesterol/PL ratio and atherogenic index and significantly increased the reduced ratio of HDL-cholesterol/total cholesterol. Also EGCG significantly increased the reduced activity of lecithin cholesterol acyl transferase in ISO-treated rats. Thus, EGCG prevented the accumulation of lipids and altered the levels of lipoproteins in myocardial-infarcted rats.
Devika
P T
PT
Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608002, Tamil Nadu, India.
Stanely Mainzen Prince
P
P
D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D007545:Isoproterenol / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects*; D008074:Lipoproteins / Q000378:metabolism*; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008074:Lipoproteins; D002392:Catechin; C045651:epigallocatechin gallate; D007545:Isoproterenol