title: Relationship between IgG titers and opsonocytophagocytic activity of anti-pneumococcal antibodies after immunization with the 7-valent conjugate vaccine in allogeneic stem cell transplant.
abstract: The European Group for Blood and Marrow Transplantation has recently run a prospective, randomized trial comparing an early (3 months) vs a late (9 months) immunization program after allo-SCT with three doses of the conjugate 7-valent pneumococcal vaccine. This trial has shown that the response rate assessed 1 month after the third dose of conjugate vaccine was not inferior after an early vaccination vs a late vaccination. Part of the responder cohort of these patients (n=28) were chosen to assess the functionality of the anti-pneumococcal antibodies through an opsonophagocytic assay, 1 month after the third dose of conjugate vaccine. We have assessed the relationship between IgG titers measured by the pneumococcal ELISA and functional titers measured by opsonophagocytic assay of anti-pneumococcal antibodies. We found a significant correlation between titers for both assays, and conclude that the response to PCV7 after SCT induces functional antibodies.
authors.affiliation: Department of Hematology, Henri Mondor Teaching Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP) and Paris 12 University, Créteil, France. carlcord@club-internet.fr
authors.forename: C
authors.initials: C
authors.lastname: Cordonnier
authors.forename: M
authors.initials: M
authors.lastname: Labopin
authors.forename: K U
authors.initials: KU
authors.lastname: Jansen
authors.forename: M
authors.initials: M
authors.lastname: Pride
authors.forename: V
authors.initials: V
authors.lastname: Chesnel
authors.forename: E
authors.initials: E
authors.lastname: Bonnet
authors.forename: H
authors.initials: H
authors.lastname: Einsele
authors.forename: P
authors.initials: P
authors.lastname: Ljungman
mesh_terms: D000293:Adolescent; D000328:Adult; D001855:Bone Marrow Diseases / Q000276:immunology / Q000628:therapy*; D002648:Child; D018380:Hematopoietic Stem Cell Transplantation; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007115:Immunization Schedule; D007074:Immunoglobulin G / Q000097:blood*; D008875:Middle Aged; D009895:Opsonin Proteins / Q000276:immunology; D010587:Phagocytosis / Q000276:immunology; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D014184:Transplantation, Homologous; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology; D055815:Young Adult
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D007074:Immunoglobulin G; D009895:Opsonin Proteins; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate