title: Developmental changes in hepatic antioxidant capacity are age-and sex-dependent.
abstract: Developmental inadequacy in hepatic antioxidant defenses may contribute to chemical toxicity and pediatric liver diseases. We measured a comprehensive panel of antioxidants in liver tissue from 27 normal pediatric donors. Glutathione reductase declined with age (P = 0.008, r = -0.54, Spearman) while microsomal glutathione-S-transferase increased (GST, P<0.001, r = 0.81). Males had significantly lower superoxide dismutase and vitamin E (P<0.05) and may have lower glutathione reductase (P = 0.06), while females show less cytosolic GST (P = 0.07). Hepatic antioxidants are high in neonates, decline throughout childhood, and then increase in adolescence to adult levels.
authors.affiliation: Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
authors.forename: Shogo J
authors.initials: SJ
authors.lastname: Miyagi
authors.forename: Isaac W
authors.initials: IW
authors.lastname: Brown
authors.forename: Jessica M-L
authors.initials: JM
authors.lastname: Chock
authors.forename: Abby C
authors.initials: AC
authors.lastname: Collier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000975:Antioxidants / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008099:Liver / Q000201:enzymology* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics
chemical_list: D000975:Antioxidants