title: Septo-optic dysplasia complicated by infantile spasms and bilateral choroidal fissure arachnoid cysts.
abstract: OBJECTIVE
  septo-optic dysplasia (SOD) is the triad of optic nerve hypoplasia, panhypopituitarism, and agenesis of septum pellucidum, and has been described previously to be associated with heterotopias and midline interhemispheric cyst. We describe a case of SOD with arachnoid cysts, persistent primary hyperplastic vitreous, and malformations of cortical development.
  
  
  METHODS
  case report and review of literature.
  
  
  RESULTS
  our patient was found to have SOD, bilateral ventriculomegaly, pachygyria, gray matter heterotopia, bilateral choroidal cysts near the brainstem, and persistent primary hyperplastic vitreous. She later developed infantile spasms and required enucleation of the abnormal eye and cyst fenestration.
  
  
  CONCLUSIONS
  coincidence of seizures, SOD, bilateral choroid fissure cysts, heterotopias, and persistent primary hyperplastic vitreous is a unique constellation. It is unclear whether this represents a new syndrome or SOD spectrum variation. Patients with SOD and arachnoid cysts should be monitored for signs of herniation.
authors.affiliation: Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Children's Hospital Boston, Boston, MA 02115, USA.
authors.forename: Emir
authors.initials: E
authors.lastname: Tas
authors.forename: Molly
authors.initials: M
authors.lastname: Tracy
authors.forename: Dean P
authors.initials: DP
authors.lastname: Sarco
authors.forename: Yaman Z
authors.initials: YZ
authors.lastname: Eksioglu
authors.forename: Sanjay P
authors.initials: SP
authors.lastname: Prabhu
authors.forename: Tobias
authors.initials: T
authors.lastname: Loddenkemper
mesh_terms: D016080:Arachnoid Cysts / Q000150:complications*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009900:Optic Nerve / Q000002:abnormalities; D025962:Septo-Optic Dysplasia / Q000150:complications* / Q000175:diagnosis; D012688:Septum Pellucidum / Q000002:abnormalities*; D013036:Spasms, Infantile / Q000150:complications*