title: Post-transcriptional regulons coordinate the initiation and resolution of inflammation.
abstract: Transcriptional control mechanisms chart the course of the inflammatory response by synthesizing mRNAs encoding proteins that promote or inhibit inflammation. Because these mRNAs can be long-lived, turning off their synthesis does not rapidly stop or change the direction of inflammation. Post-transcriptional mechanisms that modify mRNA stability and/or translation provide more rapid and flexible control of this process and are particularly important in coordinating the initiation and resolution of inflammation. Here, I review the surprising variety of post-transcriptional control mechanisms that regulate the initiation and resolution of inflammation and discuss how these mechanisms are integrated to coordinate this essential process.
authors.affiliation: Department of Medicine, Division of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. panderson@rics.bwh.harvard.edu
authors.forename: Paul
authors.initials: P
authors.lastname: Anderson
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000276:immunology*; D014176:Protein Biosynthesis / Q000235:genetics / Q000276:immunology*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D018085:Regulon / Q000235:genetics / Q000276:immunology*; D014158:Transcription, Genetic / Q000235:genetics / Q000276:immunology*
chemical_list: D012333:RNA, Messenger