title: Reduced health provider delay and tuberculosis mortality due to an improved hospital programme.
abstract: METHODS
  A referral hospital in Kaohsiung, Taiwan.
  
  
  OBJECTIVE
  To evaluate the impact of an in-hospital tuberculosis (TB) quality care programme initiated in May 2005 on health provider delay and outcome of newly diagnosed TB cases.
  
  
  METHODS
  Retrospective chart review of newly diagnosed TB cases presenting in 2002 and 2006. Health provider delay, clinical manifestations, management and outcome were recorded.
  
  
  RESULTS
  Overall, 327 patients before (2002) and 262 patients after (2006) the programme began were enrolled. Patients were older men (mean age 65.9 years) and 23.4% (138/589) had diabetes; 84.4% had received anti-tuberculosis treatment. The programme shortened the time for doctors to order a chest X-ray (P < 0.01), and the reporting time for smear (P < 0.0001) and culture (P < 0.0001). On multivariable analysis, risk factors for attributable mortality included age >/=65 years (OR 4.4, 95%CI 1.8-10.9, P = 0.001) and liver cirrhosis (OR 4.3, 95%CI 1.1-16.6, P = 0.04). Treatment reduced mortality by 81% (OR 0.2, 95%CI 0.1-0.4, P < 0.001) and the programme halved overall mortality (OR 0.5, 95%CI 0.3-0.8, P = 0.01), and reduced attributable mortality by 62% (OR 0.4, 95%CI 0.2-0.8, P < 0.01).
  
  
  CONCLUSIONS
  Intervention at the hospital level for quality control of TB care was instrumental in reducing health provider delay and led to a significant reduction in mortality.
authors.affiliation: Section of Infectious Diseases, Department of Internal Medicine, Shuang-Ho Hospital, Taipei, Taiwan.
authors.forename: Y-C
authors.initials: YC
authors.lastname: Liu
authors.forename: H-H
authors.initials: HH
authors.lastname: Lin
authors.forename: Y-S
authors.initials: YS
authors.lastname: Chen
authors.forename: I-J
authors.initials: IJ
authors.lastname: Su
authors.forename: T-S
authors.initials: TS
authors.lastname: Huang
authors.forename: H-C
authors.initials: HC
authors.lastname: Tsai
authors.forename: S-R
authors.initials: SR
authors.lastname: Wann
authors.forename: S S-J
authors.initials: SS
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D006769:Hospitals, General / Q000458:organization & administration / Q000592:standards; D006787:Hospitals, Veterans / Q000458:organization & administration / Q000592:standards; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010818:Practice Patterns, Physicians' / Q000458:organization & administration / Q000592:standards; D011785:Quality Assurance, Health Care / Q000458:organization & administration*; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan; D013997:Time Factors; D016896:Treatment Outcome; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents