Dual anti-angiogenic and cytotoxic properties of ruthenium(III) complexes containing pyrazolato and/or pyrazole ligands.
An oxo-bridged diruthenium(III) complex containing pyrazolato and pyrazole ligands is stable against ascorbic-acid reduction, induces apoptosis (60%, 48 h) against HeLa cells at 10 microM level and exhibits promising anti-angiogenic activity at its sub-cytotoxic concentrations. Other mononuclear ruthenium(III) complexes containing pyrazole ligands [Ru(pz)(4)X(2)](+) exhibit dual anti-angiogenic and cytotoxic properties.
Sun
Raymond Wai-Yin
RW
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
Ng
Miro Fei-Yeung
MF
Wong
Ella Lai-Ming
EL
Zhang
Jingfei
J
Chui
Stephen Sin-Yin
SS
Shek
Lam
L
Lau
Tai-Chu
TC
Che
Chi-Ming
CM
D020533:Angiogenesis Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis; D001205:Ascorbic Acid / Q000737:chemistry; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry / Q000633:toxicity*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D008024:Ligands; D008968:Molecular Conformation; D011720:Pyrazoles / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
D020533:Angiogenesis Inhibitors; D056831:Coordination Complexes; D008024:Ligands; D011720:Pyrazoles; C031280:pyrazole; D012428:Ruthenium; D001205:Ascorbic Acid