title: Obesity and post-operative complications in patients undergoing non-bariatric surgery.
abstract: As the prevalence of obesity continues to rise in society, an increasing number of patients undergoing non-bariatric surgery will be obese. Obesity is known to increase morbidity and mortality in the general population and thus is perceived as a risk factor for adverse post-surgical outcomes. This association is not clear-cut, however, and there is a lack of consensus in the literature on the risk between obesity and specific complications, in particular relating to infection, wound healing, respiratory and venous thromboembolism. The paucity of studies, as well as a lack of consistency of definition of obesity, with an over-reliance on body mass index rather than body composition analysis, may underlie this confusion. Emerging concepts position central/visceral adipose tissue as potentially key to the pathogenesis of the comorbidities associated with obesity, thus this article reviews emerging research investigating the association between visceral obesity, the metabolic syndrome and resulting post-operative complications. It is hypothesized that the state of chronic inflammation and dysmetabolism observed in visceral obese patients negatively influences post-operative outcomes and represents a potential target for pharmaconutrition. The need for further research investigating the influence of visceral adiposity on immune function post surgery and its impact on post-operative morbidity and mortality is highlighted.
authors.affiliation: Department of Surgery, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James's Hospital and Trinity College, Dublin, Ireland.
authors.forename: S L
authors.initials: SL
authors.lastname: Doyle
authors.forename: J
authors.initials: J
authors.lastname: Lysaght
authors.forename: J V
authors.initials: JV
authors.lastname: Reynolds
mesh_terms: D001823:Body Composition / Q000502:physiology*; D015992:Body Mass Index; D006801:Humans; D024821:Metabolic Syndrome / Q000150:complications / Q000378:metabolism / Q000401:mortality; D056128:Obesity, Abdominal / Q000150:complications* / Q000378:metabolism / Q000401:mortality; D011183:Postoperative Complications / Q000209:etiology* / Q000401:mortality; D015995:Prevalence; D013514:Surgical Procedures, Operative / Q000009:adverse effects* / Q000401:mortality; D016896:Treatment Outcome