Does aprotinin preserve platelets in children with acyanogenic congenital heart disease undergone surgery with cardiopulmonary bypass?
OBJECTIVE
Evaluation of the hemostatic and platelets effects in children with acyanogenic congenital heart disease undergone on-pump surgery who received aprotinin.


METHODS
A prospective randomized study was performed on children aged 30 days to 4 years who had undergone correction of acyanogenic congenital heart disease using cardiopulmonary bypass (CPB) and were divided into two groups: Control (n=9) and Aprotinin (n=10). In the Aprotinin Group the drug was administered before and during CPB and the hemostatic dysfunction was analyzed by clinical and biochemical markers. Differences were considered to be significant when P<0.05.


RESULTS
The groups were similar regarding demographic and intraoperative variables, except for a greater hemodilution in the Aprotinin Group. The drug presented no benefit regarding time of mechanical pulmonary ventilation, stay in the postoperative intensive care unit and hospital, or regarding the use of inotropic drugs and renal function. Platelet concentration was preserved with the use of Aprotinin, whereas thrombocytopenia occurred in the Control Group since the initiation of CPB. Blood loss was similar for both groups. There were no complications with the use of Aprotinin.


CONCLUSIONS
Aprotinin quantitatively preserved the blood platelets in children with acyanogenic congenital heart disease.
Ferreira
Cesar Augusto
CA
Thoracic and Cardiovascular Surgery Discipline of Surgery and Anatomy Department at Clinics Hospital of Ribeirão Preto Medical School - University of São Paulo, Brazil. cesarmonica@directnet.com.br
Vicente
Walter Villela de Andrade
WV
Evora
Paulo Roberto Barbosa
PR
Rodrigues
Alfredo José
AJ
Klamt
Jyrson Guilherme
JG
Carlotti
Ana Paula de Carvalho Panzeli
AP
Carmona
Fábio
F
Manso
Paulo Henrique
PH
D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D007611:Aprotinin / Q000009:adverse effects / Q000627:therapeutic use*; D001792:Blood Platelets / Q000187:drug effects*; D002315:Cardiopulmonary Bypass; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D013997:Time Factors
D000925:Anticoagulants; D007611:Aprotinin