title: Cytotoxic triterpene dilactones from the stems of Kadsura ananosma.
abstract: Six new triterpene dilactones with a rare rearranged pentacyclic skeleton, longipedlactones K-P (1-6), and seven known analogues (7-13) were isolated from the stems of Kadsura ananosma. Compound 1 was found to possess a unique peroxide bridge between C-1 and C-9 in rings A and B. The structures of these new compounds were established on the basis of spectroscopic data analysis, especially of their 2D NMR spectra. In the evaluation of the in vitro cytotoxicity of these compounds against a small panel of human cancer cell lines, compounds 3, 7, 9, and 13 were found to be the most potent against HL-60 acute leukemia cell.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Yang
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Jin
authors.initials: J
authors.lastname: Wen
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.forename: Yong-Bo
authors.initials: YB
authors.lastname: Xue
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D032135:Kadsura / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D007783:Lactones; D014315:Triterpenes