The resolution of inflammation and cancer.
Inflammation has long been thought to contribute to the development of cancer; however there is also clear evidence that the immune system can recognize and eliminate cancer cells. Current research suggests that cancer-associated inflammation has a dual role in tumor progression; inflammatory mediators promote the malignant activity of cancer cells by acting as growth factors and also stimulate angiogenesis, however, cancer-associated inflammation is also linked with immune-suppression that allows cancer cells to evade detection by the immune system. In this review we will discuss the dual role of inflammation in cancer and how endogenous anti-inflammatory mechanisms may equally be important in carcinogenesis.
Rodriguez-Vita
Juan
J
Inflammation Biology Group, Centre d'Immunologie Marseile-Luminy, Parc Scientifique de Luminy Case 906, 13288 Marseille, France(1).
Lawrence
Toby
T
D000241:Adenosine / Q000276:immunology; D000818:Animals; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000276:immunology; D018836:Inflammation Mediators / Q000276:immunology; D008055:Lipids / Q000276:immunology; D018448:Models, Immunological; D009369:Neoplasms / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control
D016207:Cytokines; D018836:Inflammation Mediators; D008055:Lipids; D000241:Adenosine