title: A beta-carboline alkaloid from the Papua New Guinea marine sponge hyrtios reticulatus.
abstract: A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid, named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure was elucidated from spectroscopic data, including (1)H-(15)N HMBC NMR experiments, which provided complementary (15)N chemical shift information in support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lines.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA.
authors.forename: Wayne D
authors.initials: WD
authors.lastname: Inman
authors.forename: Walter M
authors.initials: WM
authors.lastname: Bray
authors.forename: Nadine C
authors.initials: NC
authors.lastname: Gassner
authors.forename: R Scott
authors.initials: RS
authors.lastname: Lokey
authors.forename: Karen
authors.initials: K
authors.lastname: Tenney
authors.forename: Young Yongchun
authors.initials: YY
authors.lastname: Shen
authors.forename: Karen
authors.initials: K
authors.lastname: Tendyke
authors.forename: Ted
authors.initials: T
authors.lastname: Suh
authors.forename: Phillip
authors.initials: P
authors.lastname: Crews
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D019073:HT29 Cells; D006367:HeLa Cells; D006801:Humans; D008297:Male; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010219:Papua New Guinea; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D002243:Carbolines; C548211:hyrtiocarboline