title: A characterisation study on the application of inverted lyotropic phases for subcutaneous drug release.
abstract: An experimental characterisation of lipid mixtures consisting of inverted hexagonal and inverted cubic phases composed of soybean phosphatidylcholine (SPC) and glycerol dioleate (GDO) was performed. The release of five chromophores of varying lipophilicity, used as model drugs, was investigated. Two experimental setups were applied: one based on maintaining sink condition, while a constant volume release medium was employed for the other. For neither setup, no correlation between the model drug lipophilicity and the polarity of the carrier matrix was found. However, the lipid phases showed a prolonged release, spanning weeks, of the model drugs, which exhibit lipophilicity values ranging by four orders of magnitude.
authors.affiliation: Department of Chemistry, Umeå University, Linneus v. 10, S-901 87 Umeå, Sweden.
authors.forename: Erik
authors.initials: E
authors.lastname: Rosenbaum
authors.forename: Staffan
authors.initials: S
authors.lastname: Tavelin
authors.forename: Lennart B-A
authors.initials: LB
authors.lastname: Johansson
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations; D004075:Diglycerides / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D010713:Phosphatidylcholines / Q000737:chemistry*; D013025:Glycine max / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004075:Diglycerides; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D010713:Phosphatidylcholines; C013965:diolein