title: No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment.
abstract: Genetic polymorphisms seem to influence the response on antidepressant treatment and moderate the impact of stress on depression. The present study aimed to assess, whether allelic variants and stressful life events interact on the clinical outcome of depression. In a sample of 290 systematically recruited patients diagnosed with a single depressive episode according to ICD-10, we assessed the outcome of antidepressant treatment and the presence of stressful life events in a 6-month period preceding onset of depression by means of structured interviews. Further, we genotyped nine polymorphisms in the genes encoding the serotonin transporter, brain derived neurotrophic factor, catechol-O-methyltransferase, angiotensin converting enzyme, tryptophan hydroxylase, and the serotonin receptors 1A, 2A, and 2C. We found no evidence that the effects of the genetic polymorphisms on treatment outcome were dependent on stressful life events experienced by the individual prior to onset of depression.
authors.affiliation: Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Denmark. jens.bukh@rh.regionh.dk
authors.forename: Jens Drachmann
authors.initials: JD
authors.lastname: Bukh
authors.forename: Camilla
authors.initials: C
authors.lastname: Bock
authors.forename: Maj
authors.initials: M
authors.lastname: Vinberg
authors.forename: Thomas
authors.initials: T
authors.lastname: Werge
authors.forename: Ulrik
authors.initials: U
authors.lastname: Gether
authors.forename: Lars Vedel
authors.initials: LV
authors.lastname: Kessing
mesh_terms: D000328:Adult; D000483:Alleles; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000235:genetics / Q000523:psychology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012720:Severity of Illness Index; D013315:Stress, Psychological / Q000235:genetics* / Q000523:psychology; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents