title: Taking off the SOCS: cytokine signaling spurs regeneration.
abstract: Strategies to improve function after CNS injuries must contend with the failure of axons to regrow after transection in adult mammals. In this issue of Neuron, Smith et al. provide an important advance by demonstrating that SOCS3 acts as a key negative regulator of adult optic nerve regeneration.
authors.affiliation: Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. jason_newbern@med.unc.edu
authors.forename: Jason M
authors.initials: JM
authors.lastname: Newbern
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Shoemaker
authors.forename: William D
authors.initials: WD
authors.lastname: Snider
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D009416:Nerve Regeneration / Q000502:physiology*; D009901:Optic Nerve Diseases / Q000235:genetics / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology*; D050826:Suppressor of Cytokine Signaling Proteins / Q000009:adverse effects* / Q000235:genetics / Q000378:metabolism
chemical_list: D050826:Suppressor of Cytokine Signaling Proteins