Towards accurate imputation of quantitative genetic interactions.
Recent technological breakthroughs have enabled high-throughput quantitative measurements of hundreds of thousands of genetic interactions among hundreds of genes in Saccharomyces cerevisiae. However, these assays often fail to measure the genetic interactions among up to 40% of the studied gene pairs. Here we present a novel method, which combines genetic interaction data together with diverse genomic data, to quantitatively impute these missing interactions. We also present data on almost 190,000 novel interactions.
Ulitsky
Igor
I
Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel. ulitsky@wi.mit.edu
Krogan
Nevan J
NJ
Shamir
Ron
R
D030541:Databases, Genetic; D004843:Epistasis, Genetic / Q000235:genetics*; D005800:Genes, Fungal / Q000235:genetics*; D005821:Genetic Techniques; D023281:Genomics / Q000379:methods*; D016014:Linear Models; D012441:Saccharomyces cerevisiae / Q000235:genetics*