Grading the commercial optical biosensor literature-Class of 2008: 'The Mighty Binders'.
Optical biosensor technology continues to be the method of choice for label-free, real-time interaction analysis. But when it comes to improving the quality of the biosensor literature, education should be fundamental. Of the 1413 articles published in 2008, less than 30% would pass the requirements for high-school chemistry. To teach by example, we spotlight 10 papers that illustrate how to implement the technology properly. Then we grade every paper published in 2008 on a scale from A to F and outline what features make a biosensor article fabulous, middling or abysmal. To help improve the quality of published data, we focus on a few experimental, analysis and presentation mistakes that are alarmingly common. With the literature as a guide, we want to ensure that no user is left behind.
Rich
Rebecca L
RL
Center for Biomolecular Interaction Analysis, University of Utah, Salt Lake City, UT 84132, USA.
Myszka
David G
DG
D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods / Q000639:trends*; D003627:Data Interpretation, Statistical; D007700:Kinetics; D055095:Optics and Photonics; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D012107:Research Design; D020349:Surface Plasmon Resonance / Q000295:instrumentation / Q000379:methods / Q000639:trends
D011506:Proteins