title: [Evaluation of scalene lymph node or contralateral mediastinum biopsy during mediastinoscopy for non-small cell lung cancer].
abstract: OBJECTIVE
  To explore the clinical indication of N3 lymph node biopsy during mediastinoscopy for non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Cervical mediastinoscopy was performed in 89 patients with clinical stage I-IIIA non-small cell lung cancer prior to thoracotomy. Of those, 12 underwent cervical medistinoscopy combined with right scalene lymph node biopsy and 10 with anterior mediastinotomy.
  
  
  RESULTS
  Nine patients were found to have lymph node metastasis (N3 disease) during mediastinosopy. Of those, 6 had contralateral mediastinal lymph node metastasis and 3 cases with right scalene lymph node metastasis. The incidence of N3 disease in the patients with adenocarcinoma, serum CEA > 5 ng/ml and multi-station mediastinal lymph node metastasis was significantly higher than that in those with non-adenocarcinoma, CEA < 5 ng/ml and ipsilateral uni-station mediastinal lymph nodes metastasis (P < 0.05).
  
  
  CONCLUSIONS
  Biopsy of scalene lymph node or contralateral mediastinal lymph node should be performed during mediastinoscopy in order to exclude N3 disease for potentially operable NSCLC patients with adenocarcinoma, serum CEA >5 ng/ml and ipsilateral multi-station mediastinal lymph nodes metastasis.
authors.affiliation: State Key Laboratory of Oncology in Southern China, Department of Thoracic Surgery, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yu
authors.forename: Shi-yi
authors.initials: SY
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Ze-ming
authors.initials: ZM
authors.lastname: Xie
authors.forename: Jun-ye
authors.initials: JY
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Xuan
authors.initials: X
authors.lastname: Xie
authors.forename: Jia-liang
authors.initials: JL
authors.lastname: Zhou
authors.forename: Lan-jun
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Fu
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000473:pathology*; D000328:Adult; D000368:Aged; D001706:Biopsy; D002272:Carcinoembryonic Antigen / Q000097:blood; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008481:Mediastinoscopy; D008482:Mediastinum; D008875:Middle Aged; D009334:Neck Muscles; D009367:Neoplasm Staging
chemical_list: D002272:Carcinoembryonic Antigen