Enantiomer analysis of chiral carboxylic acids by AIE molecules bearing optically pure aminol groups.
Pure enantiomers of carboxylic acids are a class of important biomolecules, chiral drugs, chiral reagents, etc. Analysis of the enantiomers usually needs expensive instrument or complex chiral receptors. However, to develop simple and reliable methods for the enantiomer analysis of acids is difficult. In this paper, chiral recognition of 2,3-dibenzoyltartaric acid and mandelic acid was first carried out by aggregation-induced emission molecules bearing optically pure aminol group, which was easily synthesized. The chiral recognition is not only seen by naked eyes but also measured by fluorophotometer. The difference of fluorescence intensity between the two enantiomers of the acids aroused by the aggregation-induced emission molecules was up to 598. The chiral recognition could be applied to quantitative analysis of enantiomer content of chiral acids. More chiral AIE amines need to be developed for enantiomer analysis of more carboxylic acids.
Zheng
Yan-Song
YS
Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, PR China. zyansong@hotmail.com
Hu
Yu-Jian
YJ
Li
Dong-Mi
DM
Chen
Yi-Chang
YC
D000588:Amines / Q000737:chemistry; D002264:Carboxylic Acids / Q000032:analysis* / Q000737:chemistry*; D055620:Optical Phenomena; D013050:Spectrometry, Fluorescence; D013237:Stereoisomerism
D000588:Amines; D002264:Carboxylic Acids