Adipokine profile and urinary albumin excretion in isolated growth hormone deficiency.
BACKGROUND
GH deficiency (GHD) is often associated with cardiovascular risk factors, including abdominal fat accumulation, hypercholesterolemia, and increased C-reactive protein. Despite the presence of these risk factors, adults with congenital lifetime isolated GHD (IGHD) due to an inactivating mutation in the GHRH receptor gene do not have premature atherosclerosis.


OBJECTIVE
The aim was to study the serum levels of adiponectin and leptin (antiatherogenic and atherogenic adipokine, respectively), and the urinary albumin excretion (UAE) in these IGHD individuals.


METHODS
We conducted a cross-sectional study of 20 IGHD individuals (seven males; age, 50.8 +/- 14.6 yr) and 22 control subjects (eight males; age, 49.9 +/- 11.5 yr).


METHODS
Anthropometric factors, body composition, blood pressure, serum adiponectin, leptin, and UAE were measured.


RESULTS
Adiponectin was higher [12.8 (7.1) vs. 9.7 (5) ng/ml; P = 0.041] in IGHD subjects, whereas no difference was observed in leptin [7.3 (6.3) vs. 9.3 (18.7 ng/ml] and UAE [8.6 (13.8) vs. 8.5 (11.1) microg/min].


CONCLUSIONS
Subjects with lifetime untreated IGHD have an adipokine profile with high adiponectin and normal leptin levels that may delay vascular damage and lesions of the renal endothelium.
Oliveira
Carla R P
CR
Division of Endocrinology, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA.
Salvatori
Roberto
R
Meneguz-Moreno
Rafael A
RA
Aguiar-Oliveira
Manuel H
MH
Pereira
Rossana M C
RM
Valença
Eugênia H A
EH
Araujo
Vanessa P
VP
Farias
Natália T
NT
Silveira
Débora C R
DC
Vieira
Jose G H
JG
Barreto-Filho
Jose A S
JA
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000652:urine*; D003430:Cross-Sectional Studies; D005260:Female; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018013:Receptors, Neuropeptide / Q000235:genetics; D018017:Receptors, Pituitary Hormone-Regulating Hormone / Q000235:genetics; D012044:Regression Analysis
D052242:Adiponectin; D020738:Leptin; D018013:Receptors, Neuropeptide; D018017:Receptors, Pituitary Hormone-Regulating Hormone; D019382:Human Growth Hormone; C048250:somatotropin releasing hormone receptor