Specific recognition of DNA by small molecules.
DNA exhibits many attractive features in the development of drug design and disease treatment, and there are some successful events for drugs targeting to DNA in clinic use. Nowadays, the specific recognition of DNA by small molecules is the crucial factor of the sustainable development of DNA-target drugs, for the serious side-effects of existing drugs. In this review, we discussed the current efforts of DNA-drug specific interaction that concerned with various DNA recognition models, such as abasic, mismatch or bulge site recognition, specific sequence recognition, and secondary structure recognition. Some compounds are found to show a remarkable potential to be an ideal drug.
Du
Y H
YH
College of Chemical and Molecular, Sciences, Wuhan University, Hubei, Wuhan 430072, P. R. of China.
Huang
J
J
Weng
X C
XC
Zhou
X
X
D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D055808:Drug Discovery; D006801:Humans; D008970:Molecular Weight; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000378:metabolism*; D013379:Substrate Specificity
D004364:Pharmaceutical Preparations; D004247:DNA