[A novel mechanism for H. pylori-induced cell damage--induction of gene mutation by AID].
H. pylori infection causes gastric cancer development through gastritis. However, the precise mechanism for H. pylori-induced carcinogenesis remains unclear. On the other hand, accumulation of gene mutations is a hallmark of cancers, but mechanism of endogenous induction of mutation also remains unknown. Here, we found that H. pylori infection triggers aberrant expression of activation-induced cytidine deaminase (AID), a molecule that can induce DNA somatic hypermutation of immunoglobulin gene in B cells under physiological condition, in the gastric mucosa via NFkappaB-dependent mechanism. Induction of AID then enhances various gene mutations including p53. This mechanism appears to play important roles in gastric carcinogenesis by H. pylori infection.
Chiba
Tsutomu
T
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University.
Marusawa
Hiroyuki
H
Matsumoto
Yuko
Y
D000818:Animals; D003564:Cytidine Deaminase / Q000502:physiology*; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D009154:Mutation; D013274:Stomach Neoplasms / Q000209:etiology*
D003564:Cytidine Deaminase