[Amino acid chloramines and chlorimines as antiplatelet agents: reactive properties and mechanism of action].
Oxidative modifications of thiols, disulfide, and thioester atomic groups in proteins, peptides, and amino acids induced by chloramines or chloramine derivatives of amino acids and other reactive oxidants are considered. In the case of disulfide and thiol groups, production of sulfur-reactive groups may take place, such as disulphide S-oxides and sulphenic groups. Various chloramines and chloramines differently modify sulfur-containing groups. For example, N,N-dichlorotaurine rapidly modifies the thiolgroup in reduced glutathione and N-chloroglycine readily oxidizes the thioester group in methionine. Amino acid chloramines inhibit platelet aggregation by modifying S-containing centres. Autodecay of amino acid chloramines does not affect aggregation as follows from the absence of positive correlation between chloramines decay rate and antiplatelet activity. N,N-dichlorotaurine and its chlorimine derivatives are characterized by high stability and have good prospects as potential antiaggregants.
Murina
M A
MA
Roshchupkin
D I
DI
Petrova
A O
AO
Sergienko
V I
VI
D000596:Amino Acids / Q000737:chemistry* / Q000493:pharmacokinetics; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002700:Chloramines / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000493:pharmacokinetics; D011817:Rabbits
D000596:Amino Acids; D002700:Chloramines; D010975:Platelet Aggregation Inhibitors