A simple procedure to prevent chronic vaginal colpotomy wound bleeding after laparoscopically assisted vaginal hysterectomy.
OBJECTIVE
To determine whether injecting the colpotomy wound with diluted vasopressin decreases vaginal bleeding after laparoscopically assisted vaginal hysterectomy (LAVH).


METHODS
In this prospective controlled study 100 patients who underwent LAVH from July 1, 2005 to June 30, 2007, were randomized to receive an injection of vasopressin (n=50) or normal saline (n=50) solution in the colpotomy wound.


RESULTS
In the vasopressin group, bleeding from the colpotomy wound occurred for more than 7 days in 9 patients (18%), and none was bleeding after 1 month; in the control group, the corresponding values were 29 (58%) and 2 (4%). Compared with the study group, the control group had a significantly higher rate of chronic bleeding from the colpotomy wound for more than 7 days and for more than 14 days after LAVH (P<0.001 for both).


CONCLUSIONS
Infiltrating the colpotomy wound with diluted vasopressin was found to prevent chronic vaginal bleeding, which frequently occurs following LAVH.
Seow
Kok-Min
KM
Department of Obstetrics and Gynecology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Lin
Yu-Hung
YH
Hwang
Jiann-Loung
JL
Huang
Lee-Wen
LW
Pan
Ching-Pin
CP
D016063:Blood Loss, Surgical / Q000517:prevention & control*; D020884:Colpotomy / Q000009:adverse effects*; D005260:Female; D006490:Hemostatics / Q000008:administration & dosage*; D006801:Humans; D007045:Hysterectomy, Vaginal; D015552:Injections, Intralesional; D010535:Laparoscopy; D011446:Prospective Studies; D014667:Vasopressins / Q000008:administration & dosage*
D006490:Hemostatics; D014667:Vasopressins