title: Xanthophylls and eye health of infants and adults.
abstract: Lutein and zeaxanthin are the only carotenoids present in the eye. They cannot be synthesized de novo and are specifically concentrated in the macula. They appear to have at least two major functions: to filter out blue light and thus prevent ensuing damages to the eye and to act as antioxidants. Infants are particularly at risk from both blue light and oxidative damage to eye tissues. Lutein is present in human milk but is not currently added to infant formulas. Fortifying formulae with lutein in order to match more closely human milk might help protect the infant's sensitive eyes. In adults, the exact pathogenesis of age-related maculopathy remains unknown. Light damage, inflammation, and the disruption of cellular processes by oxidative stress may play an important role in the degenerative process. Manipulation of intake of xanthophylls has been shown to augment macular pigment, therefore it is thought that carotenoid dietary supplements could prevent, delay, or modify the course of age-related maculopathy. However, definite evidence of the effect of carotenoids, the optimal doses to use, and the supplementation duration are still under investigation.
authors.affiliation: Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Hôtel-Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon. amoukarzel@pol.net
authors.forename: Adib A
authors.initials: AA
authors.lastname: Moukarzel
authors.forename: Riad A
authors.initials: RA
authors.lastname: Bejjani
authors.forename: Florence N
authors.initials: FN
authors.lastname: Fares
mesh_terms: D002338:Carotenoids / Q000008:administration & dosage; D005123:Eye / Q000737:chemistry / Q000378:metabolism / Q000503:physiopathology*; D006304:Health Status; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000737:chemistry; D007231:Infant, Newborn; D007249:Inflammation / Q000517:prevention & control; D014975:Lutein / Q000008:administration & dosage / Q000502:physiology; D008268:Macular Degeneration / Q000209:etiology / Q000517:prevention & control*; D008895:Milk, Human / Q000737:chemistry; D009799:Ocular Physiological Phenomena; D018384:Oxidative Stress; D012307:Risk Factors; D024341:Xanthophylls / Q000008:administration & dosage / Q000502:physiology*; D065146:Zeaxanthins
chemical_list: D024341:Xanthophylls; D065146:Zeaxanthins; D002338:Carotenoids; D014975:Lutein