title: Establishment and characterization of androgen-independent human prostate cancer cell lines, PcBra1, PcBra2, and PcBra3.
abstract: One of the main obstacles for understanding biological events involved in cancer is the lack of experimental models for in vitro studies especially for prostate cancer (PC). There are a limited number of PC cell lines being the majority originated from metastatic tumors mostly acquired from American Tissue Cell Culture which demands importation an expensive and bureaucratic process. Also it is well known that there are ethnic differences between populations concerning the behavior of tumors and the research based on cell lines derived from Brazilians should be interesting. Our aim was to develop tumor cell lines from primary PC.
authors.affiliation: Laboratory of Medical Investigation, Urology Department-LIM55, Medical School, São Paulo University, Av. Dr. Arnaldo 455, Room 2145, 01246-903, São Paulo, Brazil.
authors.forename: Camila B
authors.initials: CB
authors.lastname: Piantino
authors.forename: Juliana M
authors.initials: JM
authors.lastname: Sousa-Canavez
authors.forename: Marta
authors.initials: M
authors.lastname: Bellodi-Privato
authors.forename: Miguel
authors.initials: M
authors.lastname: Srougi
authors.forename: Luiz Heraldo
authors.initials: LH
authors.lastname: Camara-Lopes
authors.forename: Gilka Jorge Figaro
authors.initials: GJ
authors.lastname: Gattás
authors.forename: Fernanda de Toledo
authors.initials: Fde T
authors.lastname: Gonçalves
authors.forename: Cintia
authors.initials: C
authors.lastname: Fridman
authors.forename: Katia R M
authors.initials: KR
authors.lastname: Leite
mesh_terms: D000728:Androgens / Q000502:physiology; D000818:Animals; D045744:Cell Line, Tumor; D015925:Cryopreservation; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D051379:Mice; D008819:Mice, Nude; D011471:Prostatic Neoplasms / Q000235:genetics / Q000473:pathology*
chemical_list: D000728:Androgens