Glyco-conjugates as elicitors or suppressors of plant innate immunity.
Innate immunity is the first line of defense against invading microorganisms in vertebrates and the only line of defense in invertebrates and plants. Bacterial glyco-conjugates, such as lipopolysaccharides (LPS) from the outer membrane of Gram-negative bacteria and peptidoglycan (PGN) from the cell walls of both Gram-positive and Gram-negative bacteria, and fungal and oomycete glycoconjugates such as oligosaccharides derived from the cell wall components beta-glucan, chitin and chitosan, have been found to act as elicitors of plant innate immunity. These conserved indispensable microbe-specific molecules are also referred to as microbe-associated molecular patterns (MAMPs). Other glyco-conjugates such as bacterial extracellular polysaccharides (EPS) and cyclic glucan have been shown to suppress innate immune responses, thus conversely promoting pathogenesis. MAMPs are recognized by the plant innate immune system though the action of pattern recognition receptors (PRRs). A greater insight into the mechanisms of MAMP recognition and the description of PRRs for different microbial glyco-conjugates will have considerable impact on the improvement of plant health and disease resistance. Here we review the current knowledge about the bacterial MAMPs LPS and PGN, the fungal MAMPs beta-glucan, chitin and chitosan oligosaccharides and the bacterial suppressors EPS and cyclic glucan, with particular reference to the chemical structures of these molecules, the PRRs involved in their recognition (where these have been defined), and possible mechanisms underlying suppression.
Silipo
Alba
A
Dipartimento di Chimica Organica e Biochimica, Università di Napoli Federico II, Napoli, Via Cintia, 4. I-80126, Italy.
Erbs
Gitte
G
Shinya
Tomonori
T
Dow
J Maxwell
JM
Parrilli
Michelangelo
M
Lanzetta
Rosa
R
Shibuya
Naoto
N
Newman
Mari-Anne
MA
Molinaro
Antonio
A
D000941:Antigens / Q000276:immunology; D001419:Bacteria / Q000276:immunology / Q000378:metabolism; D002473:Cell Wall / Q000276:immunology / Q000378:metabolism; D002686:Chitin / Q000276:immunology; D005936:Glucans / Q000276:immunology*; D007113:Immunity, Innate; D008070:Lipopolysaccharides / Q000276:immunology*; D010457:Peptidoglycan / Q000276:immunology*; D010944:Plants / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D011135:Polysaccharides, Bacterial / Q000276:immunology; D051192:Receptors, Pattern Recognition / Q000276:immunology / Q000378:metabolism; D047071:beta-Glucans / Q000276:immunology
D000941:Antigens; D005936:Glucans; D008070:Lipopolysaccharides; D010457:Peptidoglycan; D011135:Polysaccharides, Bacterial; D051192:Receptors, Pattern Recognition; D047071:beta-Glucans; D002686:Chitin