The multifunctional leucine-rich repeat receptor kinase BAK1 is implicated in Arabidopsis development and immunity.
Plant receptor-like kinases (RLKs) are transmembrane proteins with putative N-terminal extracellular ligand-binding domains and C-terminal intracellular protein kinase domains. RLKs have been implicated in multiple physiological programs including plant development and immunity to microbial infection. Arabidopsis thaliana gene expression patterns support an important role of this class of proteins in biotic stress adaptation. Here, we provide a comprehensive survey of plant immunity-related RLK gene expression. We further document the role of the Arabidopsis Brassinosteroid Insensitive 1 (BRI1)-associated receptor kinase 1 (BAK1) in seemingly unrelated biological processes, such as plant development and immunity, and propose a role of this protein as an adaptor molecule that is required for proper functionality of numerous RLKs. This view is supported by the identification of an additional RLK, PEPR1, and its closest homolog, PEPR2 as BAK1-interacting RLKs.
Postel
Sandra
S
Zentrum für Molekularbiologie der Pflanzen-Pflanzenbiochemie, Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 5, D-72076 Tübingen, Germany.
Küfner
Isabell
I
Beuter
Christine
C
Mazzotta
Sara
S
Schwedt
Anne
A
Borlotti
Andrea
A
Halter
Thierry
T
Kemmerling
Birgit
B
Nürnberger
Thorsten
T
D017360:Arabidopsis / Q000201:enzymology / Q000254:growth & development / Q000276:immunology; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D016000:Cluster Analysis; D019295:Computational Biology; D015971:Gene Expression Regulation, Enzymologic; D018506:Gene Expression Regulation, Plant; D007107:Immune System / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism
D029681:Arabidopsis Proteins; C512592:PEPR1 protein, Arabidopsis; D011956:Receptors, Cell Surface; C463660:BAK1 protein, Arabidopsis; C582179:PEPR2 protein, Arabidopsis; D017346:Protein Serine-Threonine Kinases