title: A G-coupled receptor protein critical for peripheral nerve myelination.
abstract: Intercellular signaling between the axon and myelinating glial cells plays an essential role in the regulation of the myelination process. A recent study from Monk et al. has used a forward genetics approach in zebrafish to identify a G protein-coupled receptor that is necessary for Schwann cells to myelinate axons, thereby uncovering a critical component of the axo-glial signaling network.
authors.affiliation: The Jack Miller Center for Peripheral Neuropathy, Department of Neurology, The University of Chicago, 5841 South Maryland Avenue, MC2030, Chicago, IL 60637, USA.
authors.forename: Shen Yi B
authors.initials: SY
authors.lastname: Howng
authors.forename: Darlene S
authors.initials: DS
authors.lastname: Douglas
authors.forename: Brian
authors.initials: B
authors.lastname: Popko
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism; D051767:Early Growth Response Protein 2 / Q000378:metabolism; D009186:Myelin Sheath / Q000502:physiology*; D020890:Neuregulin-1 / Q000378:metabolism; D027701:Organic Cation Transport Proteins / Q000378:metabolism; D010525:Peripheral Nerves / Q000166:cytology / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D012583:Schwann Cells / Q000166:cytology / Q000378:metabolism; D015398:Signal Transduction; D015027:Zebrafish / Q000235:genetics / Q000378:metabolism
chemical_list: D051767:Early Growth Response Protein 2; D020890:Neuregulin-1; D027701:Organic Cation Transport Proteins; D043562:Receptors, G-Protein-Coupled