Management of metastatic urothelial cancer: the role of surgery as an adjunct to chemotherapy.
Metastatic or unresectable disease is identified in approximately 20% of patients presenting with invasive urothelial cancer. In addition, up to 50% of patients will develop metastases following radical cystectomy for clinically localized disease. Multiagent cisplatin-based chemotherapy is considered standard first-line treatment for these patients. Although urothelial cancer is considered a chemosensitive tumour, metastatic disease is associated with poor prognosis and short-term survival. Here, we review the role of a multidisciplinary approach to treating patients with metastatic urothelial cancer.
Svatek
Robert S
RS
The University of Texas MD Anderson Cancer Center, Department of Urologic Oncology;
Siefker-Radtke
Arlene
A
Dinney
Colin P
CP