title: IGF-1 partially restores chemotherapy-induced reductions in neural cell proliferation in adult C57BL/6 mice.
abstract: Chemotherapeutic agents produce persistent difficulties in memory through an unknown mechanism. We tested the hypothesis that chemotherapeutic agents readily able to cross the blood-brain barrier (cyclophosphamide and fluorouracil), as opposed to those not known to readily cross the barrier (paclitaxel and doxorubicin), reduce neural cell proliferation following chemotherapy. We found that 5-bromo-2-deoxyuridine labeling following chemotherapy given to C57BL/6 mice revealed a similar reduction in neural cell proliferation in the dentate gyrus for all four agents. Insulin-like growth factor 1, a molecule implicated in promoting neurogenesis, counteracted the effects of high doses of chemotherapy on neural cell proliferation.
authors.affiliation: Department of Radiation Oncology, University of Rochester Medical Center, New York 14642, USA. michelle_janelsins@urmc.rochester.edu
authors.forename: Michelle C
authors.initials: MC
authors.lastname: Janelsins
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Roscoe
authors.forename: Michel J
authors.initials: MJ
authors.lastname: Berg
authors.forename: Bryan D
authors.initials: BD
authors.lastname: Thompson
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Gallagher
authors.forename: Gary R
authors.initials: GR
authors.lastname: Morrow
authors.forename: Charles E
authors.initials: CE
authors.lastname: Heckler
authors.forename: Pascal
authors.initials: P
authors.lastname: Jean-Pierre
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Opanashuk
authors.forename: Robert A
authors.initials: RA
authors.lastname: Gross
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000633:toxicity*; D001812:Blood-Brain Barrier; D001973:Bromodeoxyuridine / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D003520:Cyclophosphamide / Q000633:toxicity; D018891:Dentate Gyrus / Q000187:drug effects*; D004317:Doxorubicin / Q000633:toxicity; D005472:Fluorouracil / Q000633:toxicity; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D055495:Neurogenesis / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D017239:Paclitaxel / Q000633:toxicity; D015431:Weight Loss
chemical_list: D000970:Antineoplastic Agents; D007334:Insulin-Like Growth Factor I; D004317:Doxorubicin; D003520:Cyclophosphamide; D001973:Bromodeoxyuridine; D017239:Paclitaxel; D005472:Fluorouracil