title: The developing role for intensity-modulated radiation therapy (IMRT) in the non-surgical treatment of brain metastases.
abstract: Whole brain radiotherapy (WBRT) is the standard non-surgical treatment for brain metastatic disease, but rarely eradicates bulky metastases from most common cancers. Recent literature has demonstrated the safety and efficacy of delivering very high focal doses of radiation (by radiosurgical techniques) to the gross tumour volume of bulky brain metastases, thereby obtaining more certain local control than is achieved by WBRT. In this paper we report a study of 11 patients with bulky brain metastases in whom an intensity-modulated radiation therapy (IMRT) facility has been used to concomitantly boost the gross tumour volume of bulky brain metastatic disease (to 40 Gy) during a standard 30 Gy in 10 fractions WBRT schedule. No acute or subacute morbidity was encountered, and good early control data were noted. We discuss the perceived advantages of such a technique.
authors.affiliation: Department of Radiotherapy, St. Bartholomew's Hospital, London, UK.
authors.forename: A A
authors.initials: AA
authors.lastname: Edwards
authors.forename: E
authors.initials: E
authors.lastname: Keggin
authors.forename: P N
authors.initials: PN
authors.lastname: Plowman
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000556:secondary* / Q000601:surgery; D016371:Cranial Irradiation / Q000379:methods*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D018579:Patient Selection; D016634:Radiosurgery / Q000379:methods; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000295:instrumentation / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D012062:Relative Biological Effectiveness; D016896:Treatment Outcome