[Optimization of riboflavin sodium phosphate loading to calcium alginate floating microspheres by response surface methodology].
OBJECTIVE
To investigate the preparation, optimization and in vitro properties of riboflavin sodium phosphate floating microspheres.


METHODS
The floating microspheres composed of riboflavin sodium phosphate and calcium alginate were prepared using ion gelatin-oven drying method.


RESULTS
The properties of the microspheres were investigated, including the buoyancy, release, appearance and entrapment efficiency. The formulation was optimized by response surface methodology (RSM).


CONCLUSIONS
The optimized microspheres were round. The entrapment efficiency was 57.49%. All the microspheres could float on the artificial gastric juice over 8 hours. The release of the drug from the microspheres complied with Fick's diffusion.
Zhang
An-yang
AY
Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100191, China.
Fan
Tian-yuan
TY
D000464:Alginates / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008863:Microspheres; D010710:Phosphates / Q000737:chemistry*; D012256:Riboflavin / Q000737:chemistry*; D013499:Surface Properties
D000464:Alginates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D010710:Phosphates; D020723:Glucuronic Acid; C018279:sodium phosphate; D012256:Riboflavin