title: High-dose bone morphogenetic protein-induced ectopic abdomen bone growth.
abstract: BACKGROUND
  Infuse [bone morphogenetic protein (BMP)] is increasingly used in spinal fusion surgery.
  
  
  OBJECTIVE
  The authors report a rare complication of BMP use.
  
  
  METHODS
  This is a case report.
  
  
  METHODS
  A 55-year-old male underwent a thoracic T8 to the pelvis fusion for degenerative lumbar disc disease and pseudarthrosis at another institution. The procedure involved an anterior and posterior approach with the use of multiple units of BMP.
  
  
  METHODS
  The patient presented to our institution with complaints of weight loss, pain, tenderness, and increasing solid growth in the left lower quadrant several months after his surgery. A computed tomography revealed ectopic bone growth in the retroperitoneal area and pelvis contiguous to the anterior lumbar exposure.
  
  
  RESULTS
  The anterior wound was re-explored, and a large sheet of ectopic bone was removed from the retroperitoneal space.
  
  
  CONCLUSIONS
  We report a rare case of extraspinal ectopic bone growth because of the use of multiple packages of BMP.
authors.affiliation: Rush University Medical Center, 1725 W. Harrison St. #970, Chicago, IL 60612, USA. harel_deutsch@rush.edu
authors.forename: Harel
authors.initials: H
authors.lastname: Deutsch
mesh_terms: D055396:Bone Morphogenetic Protein 2 / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000150:complications / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000209:etiology*; D011542:Pseudarthrosis / Q000150:complications / Q000601:surgery*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects; D012187:Retroperitoneal Space / Q000473:pathology* / Q000601:surgery; D013123:Spinal Fusion / Q000009:adverse effects*; D013904:Thoracic Vertebrae / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D055396:Bone Morphogenetic Protein 2; D011994:Recombinant Proteins