title: [Quantitative coronary angiography and intravascular ultrasound assessments on target lesion and reference vessel in patients with diabetes mellitus].
abstract: OBJECTIVE
  To evaluate the accuracy of quantitative coronary angiography (QCA) assessment on target lesion and reference vessel in patients with diabetes mellitus with intravascular ultrasound (IVUS) measurements as golden standard.
  
  
  METHODS
  QCA and IVUS were performed in 52 diabetes mellitus patients [35 males, mean age (62.3 +/- 7.1) years]. Regression equation was ascertained with the IVUS derived plaque burden as dependent and QCA derived vessel stenosis as independent variable. The measurement results derived from the two modalities on proximal and distal reference vessels were compared.
  
  
  RESULTS
  The regression equation (constant = 0.8286, P = 0.001) of plaque burden and vessel stenosis derived from two modalities were significantly correlated (r = 0.691, P < 0.001) but QCA overestimated the stenosis severity (57.9% +/- 15.5% vs. 53.5% +/- 12.9%, P < 0.01). Target vessels negative remodeling index in these patient was 0.87 +/- 0.23. QCA significantly underestimated the proximal and distal reference segments vessel diameters [(0.81 +/- 0.24) mm, (0.64 +/- 0.17) mm, all P < 0.05] as compared to IVUS results.
  
  
  CONCLUSIONS
  Due to the significant negative vessel remodeling, QCA overestimated the stenosis severity and underestimated the reference segments vessel diameters in patients with diabetes mellitus.
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Ze-ning
authors.initials: ZN
authors.lastname: Jin
authors.forename: Shu-zheng
authors.initials: SZ
authors.lastname: Lü
authors.forename: Yun-dai
authors.initials: YD
authors.lastname: Chen
authors.forename: Fei
authors.initials: F
authors.lastname: Yuan
authors.forename: Xian-tao
authors.initials: XT
authors.lastname: Song
authors.forename: Xiao-fan
authors.initials: XF
authors.lastname: Wu
authors.forename: Li-Jie
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Ren
authors.forename: Chang-jiang
authors.initials: CJ
authors.lastname: Ge
authors.forename: Guo-zhong
authors.initials: GZ
authors.lastname: Wang
authors.forename: Xue-wei
authors.initials: XW
authors.lastname: Xu
mesh_terms: D000368:Aged; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging*; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D018084:Ultrasonography, Interventional