title: A meta-analysis of topical prostaglandin analogs in the treatment of chronic angle-closure glaucoma.
abstract: OBJECTIVE
  To evaluate the intraocular pressure (IOP)-lowering efficacy of prostaglandin analogs topical medications in patients with chronic angle-closure glaucoma (CACG).
  
  
  METHODS
  Pertinent publications were identified through systematic searches of PubMed, EMBASE, KoreaMed, Chinese Biomedicine Database, and the Cochrane-Controlled Trials Register. Randomized clinical trials involving CACG patients treated with latanoprost, bimatoprost, or travoprost monotherapy were selected. Methodologic quality was assessed by a Delphi list with additions and scored out of a maximum of 18. The outcome measures were absolute and relative reduction in IOP from baseline, for diurnal curve, peak, and trough. The pooled effects were calculated using 2-step DerSimonian and Laird estimate method of the random effects model.
  
  
  RESULTS
  Nine randomized clinical trials enrolling a total of 1,090 patients were included in the meta-analysis. Quality scores of included studies were generally high, a mean of 14.9 (range, 12-18). The difference in absolute IOP reduction between prostaglandin analogs and timolol varied from 0.4 to 1.6 mm Hg at diurnal curve, 0.9 to 2.3 mm Hg at peak, and 1.3 to 2.4 mm Hg at trough. Relative IOP reduction were diurnal curve, 31% (95% confidence interval, 27% to 34%), peak, 34% (31% to 37%), and trough 31% (28% to 35%) for latanoprost; diurnal curve, 26% (21% to 30%), peak, 28% (24% to 32%), and trough 27% (23% to 30%) for bimatoprost; diurnal curve, 28% (20% to 36%), peak, 32% (31% to 34%), and trough 31% (29% to 33%) for travoprost; and diurnal curve, 23% (19% to 27%), peak, 24% (20% to 29%), and trough 21% (19% to 24%) for timolol.
  
  
  CONCLUSIONS
  Latanoprost, travoprost, and bimatoprost provide significant IOP-lowering efficacy in eyes with CACG; and the 3 prostaglandin analogs are associated with at least as effective as timolol.
authors.affiliation: Department of Ophthalmology, Shanghai Changzheng Hospital, Second Military Medical University, China.
authors.forename: Jin-Wei
authors.initials: JW
authors.lastname: Cheng
authors.forename: Ji-Ping
authors.initials: JP
authors.lastname: Cai
authors.forename: You
authors.initials: Y
authors.lastname: Li
authors.forename: Rui-Li
authors.initials: RL
authors.lastname: Wei
mesh_terms: D000287:Administration, Topical; D000368:Aged; D002908:Chronic Disease; D016208:Databases, Factual; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011465:Prostaglandins, Synthetic / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic
chemical_list: D011465:Prostaglandins, Synthetic