Extracellular neurotransmitter receptor clustering: think outside the box.
Postsynaptic submembrane scaffolds cluster neurotransmitter receptors through intracellular protein-protein interactions. Growing evidence supports the view that extracellular factors can be almost as important to trigger synaptic receptor aggregation.
Kneussel
Matthias
M
Center for Molecular Neurobiology, ZMNH, University of Hamburg Medical School, Falkenried 94, 20251 Hamburg, Germany. matthias.kneussel@zmnh.uni-hamburg.de
D000199:Actins / Q000378:metabolism; D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D009469:Neuromuscular Junction / Q000378:metabolism; D018091:Receptors, AMPA / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism
D000199:Actins; D029742:Caenorhabditis elegans Proteins; C492294:LEV-10 protein, C elegans; C545009:LEV-9 protein, C elegans; D008565:Membrane Proteins; D018091:Receptors, AMPA; D011950:Receptors, Cholinergic