Gabapentin use in hyperemesis gravidarum: a pilot study.
Among 7 subjects with hyperemesis gravidarum (HG), we found gabapentin therapy to be associated with mean reductions in nausea and emesis from Baseline to Days 12-14 of 80% and 94%, respectively. There have been 2 congenital defects among 7 exposed infants. Gabapentin may be effective in the treatment of HG.
Guttuso
Thomas
T
Department of Neurology, University at Buffalo, 3435 Main Street, 311 BRB, Buffalo, NY 14214, USA. tguttuso@buffalo.edu <tguttuso@buffalo.edu>
Robinson
Luther K
LK
Amankwah
Kofi S
KS
D000328:Adult; D000588:Amines / Q000627:therapeutic use*; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D005260:Female; D000077206:Gabapentin; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000188:drug therapy*; D010865:Pilot Projects; D011247:Pregnancy; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin