Radiolabelling of proteins with fluorine-18 via click chemistry.
The study describes for the first time the application of Cu(I)-mediated 1,3-dipolar [3+2]cycloaddition for the labelling of proteins with the short-lived positron emitter fluorine-18 as exemplified with azide-functionalized human serum albumin (HSA).
Ramenda
Theres
T
Institute of Radiopharmacy, Research Center Dresden-Rossendorf, Dresden, Germany.
Kniess
Torsten
T
Bergmann
Ralf
R
Steinbach
Jörg
J
Wuest
Frank
F
D000818:Animals; D003300:Copper / Q000737:chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry; D006801:Humans; D007553:Isotope Labeling; D051379:Mice; D008819:Mice, Nude; D049268:Positron-Emission Tomography; D012709:Serum Albumin / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry; D000096926:Benzenesulfonamides
D003300:Copper; D005462:Fluorine Radioisotopes; D012709:Serum Albumin; D013449:Sulfonamides; D000096926:Benzenesulfonamides