Clinicopathological characteristics of primary gastric T-cell lymphoma.
OBJECTIVE
To investigate the clinicopathological characteristics of 20 primary gastric T-cell lymphoma (GTCL) cases without human T-lymphotropic virus type I infection in Japan, a non-endemic area for coeliac disease.


RESULTS
Fifteen cases had no history of persistent diarrhoea or severe hypoproteinaemia. Histologically, 13 cases (65%) consisted of large cell lymphoma and seven (35%) were of medium-sized cells. Intraepithelial lymphoma cell invasion was found in three cases (15%). Two of 10 surgical cases (20%) showed intramucosal tumour cell spreading with enteropathy-like features. Helicobacter pylori CagA gene was detected in three of 10 cases (30%). The lymphoma cells of all 20 cases were positive for CD3 and/or TCRbetaF1 and negative for CD56. CD4- and CD8- lymphoma was found in 11 cases (55%), CD4+ lymphoma in seven (35%) and CD8+ lymphoma in two (10%). CD30+, CD5+ and CD25+ lymphomas were detected in nine (45%), 10 (50%) and 11 (55%) cases, respectively. Five-year survival of the 16 available cases was 54%. Early clinical stage and medium-sized cell lymphoma were significantly (P < 0.05) better prognostic factors.


CONCLUSIONS
Patients with GTCL exhibit distinct clinicopathological findings and prognoses from those with enteropathy-associated T-cell lymphomas. GTCL may be mainly derived from lamina propria and parafollicular T cells.
Kawamoto
Kenichiro
K
Department of Pathology, Faculty of Medicine, Fukuoka University, Nanakuma 7-15-2, Jonan-ku, Fukuoka 814-0180, Japan.
Nakamura
Shotaro
S
Iwashita
Akinori
A
Watanabe
Jiro
J
Oshiro
Yumi
Y
Nakayama
Yoshifuku
Y
Nimura
Satoshi
S
Kimura
Nobuhiro
N
Aoyagi
Kunihiko
K
Yao
Takashi
T
Kuramochi
Shigeru
S
Matsuyama
Atsuji
A
Kurihara
Kenji
K
Ohshima
Koichi
K
Takeshita
Morishige
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D019675:Genes, T-Cell Receptor gamma / Q000502:physiology; D016481:Helicobacter Infections / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017403:In Situ Hybridization; D016411:Lymphoma, T-Cell, Peripheral / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016601:RNA-Binding Proteins / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012269:Ribosomal Proteins / Q000378:metabolism; D013270:Stomach / Q000382:microbiology / Q000473:pathology*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology
D015703:Antigens, CD; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; C067169:RPL22 protein, human