title: Infratentorial lesion volume correlates with sensory functional system in multiple sclerosis patients: a 3.0-Tesla MRI study.
abstract: OBJECTIVE
  This study sought to correlate lesion volume in infratentorial areas using 3.0-T proton-density (PD)-weighted images with disability scales and appropriate functional system scores in patients with multiple sclerosis (MS).
  
  
  METHODS
  We examined 20 consecutive patients (13 women and 7 men) with a median age of 47 years (range 26-70). Neurological examination included the Expanded Disability Status Scale and its functional systems, the Barthel Index (BI) and the Rivermead Mobility Index (RMI). MRI scans were performed on a system operating at 3.0 T using a quadrature birdcage head coil. Acquired images imported as Digital Imaging and Communication in Medicine (DICOM) files, and the region of interest (ROI) files were converted to Neuroimaging Informatics Technology Initiative (NIfTI) format and normalised to the Montreal Neurological Institute (MNI) standard template. An automated segmentation algorithm was used to distinguish between supratentorial and infratentorial areas. Normalisation to the magnetisation-prepared rapid acquisition with gradient echo (MPRAGE) T1-weighted sequence allowed lesion volume estimation in the different anatomical areas.
  
  
  RESULTS
  A significant correlation was found between infratentorial lesion volume and the sensory functional system score (rho=0.76, p=0.002). No significant correlation was found between supratentorial lesion volume and Expanded Disability Status Scale (EDSS), RMI and BI scores.
  
  
  CONCLUSIONS
  The described method, by means of anatomical assignment of MS lesions, allows detection of significant correlation coefficients between clinical and MRI lesion burden in MS patients at the infratentorial level.
authors.affiliation: Department of Radiology, IRCCS Fondazione Santa Lucia, Rome, Italy. c.quattrocchi@unicampus.it
authors.forename: C C
authors.initials: CC
authors.lastname: Quattrocchi
authors.forename: A
authors.initials: A
authors.lastname: Cherubini
authors.forename: G
authors.initials: G
authors.lastname: Luccichenti
authors.forename: M G
authors.initials: MG
authors.lastname: Grasso
authors.forename: U
authors.initials: U
authors.lastname: Nocentini
authors.forename: B
authors.initials: B
authors.lastname: Beomonte Zobel
authors.forename: U
authors.initials: U
authors.lastname: Sabatini
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001933:Brain Stem / Q000473:pathology* / Q000503:physiopathology*; D002531:Cerebellum / Q000473:pathology / Q000503:physiopathology; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology* / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index