Imaging circulating cells and lymphoid tissues with iron oxide nanoparticles.
The use of nanometer-sized iron oxide nanoparticles and micron-sized iron oxide particles as magnetic resonance (MR) contrast agents has garnered a high degree of interest in diverse areas of biology and medicine. Applications such as cell tracking, molecular imaging, gene detection, and lymphography are being explored to provide insight into disease mechanisms, monitor therapeutic efficacy, and facilitate diagnostic imaging. What makes iron oxide so appealing is a number of favorable properties including high detectability by MR, biodegradability and low toxicity. Here we describe the recent progress on the use of magnetic nanoparticles in imaging circulating cells and lymphoid tissues. The study of the lymph system and the biodistribution of various circulating immune cells is important in the diagnosis, prognosis, and treatment of a wide range of diseases and is expected to have a profound effect on patient outcome.
Elias
Andrew
A
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA. raelias@seas.upenn.edu
Tsourkas
Andrew
A
D000818:Animals; D001773:Blood Cells / Q000737:chemistry / Q000648:ultrastructure*; D003287:Contrast Media / Q000032:analysis / Q000493:pharmacokinetics; D003911:Dextrans; D005290:Ferric Compounds / Q000032:analysis / Q000493:pharmacokinetics; D052203:Ferrosoferric Oxide / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity; D006801:Humans; D007275:Injections, Intravenous; D008214:Lymphocytes / Q000737:chemistry / Q000648:ultrastructure; D008221:Lymphoid Tissue / Q000737:chemistry / Q000648:ultrastructure*; D008264:Macrophages / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D051379:Mice; D053758:Nanoparticles / Q000032:analysis; D014018:Tissue Distribution
D003287:Contrast Media; D003911:Dextrans; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide; C065507:ferumoxides; D052203:Ferrosoferric Oxide