Study of acute hepatotoxicity of Equisetum arvense L. in rats.
OBJECTIVE
To evaluate the acute hepatotoxicity of Equisentum arvense L. in rats.


METHODS
Fifty Wistar rats were used, these being divided in four groups, one being the control (receiving only water) and the other groups receiving graded doses of Equisentum arvense L. (30, 50, and 100mg/kg respectively) for 14 days. Blood samples were obtained to determine TGO, TGP, FA, DHL and GT-gamma activities. After that, hepatic tissue samples were collected for the anatomopathologic analysis.


RESULTS
The anatomopathologic exam of the hepatic tissue showed organ with preserved lobular structure. In the same way, there was no significant change in the seric activities of the hepatic enzymes when compared to control group.


CONCLUSIONS
The oral treatment with graded doses of Equisentum arvense L. was not able to produce hepatic changes. Further studies are necessary to evaluate the chronic hepatotoxicity of Equisentum arvense L. in rats.
Baracho
Nilo César do Vale
NC
Itajubá School of Medicine, Rua Marechal Juarez Távora 180, Itajubá, Minas Gerais, Brazil. nilocvbaracho@yahoo.com.br
Vicente
Bruno Battiston Vilela
BB
Arruda
Guilherme D'Andréa Saba
GD
Sanches
Brunno Cezar Framil
BC
Brito
Jarbas de
Jd
D000818:Animals; D020829:Equisetum / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D023421:Models, Animal; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric
D010936:Plant Extracts