[Influence of taxan-containing cytostatic preparations on the progeny].
In experiments designed to study effect of taxan-containing agents on the progeny of Wistar rats, one of the parents was given a single intravenous injection of the antineoplastic drug paclitaxel 1, 3 and 6 months before crossing with the untreated partner. The number of systemic pathological changes in the off-springs of paclitaxel-treated females was significantly greater and their spectrum wider than in those of the treated males. Severity of toxic effects depended on the time of crossing after drug administration. The optimal time for obtaining less affected off-springs of treated females and males was 3 and 6 months after administration of paclitaxel.
Borovskaia
T G
TG
Gol'dberg
V E
VE
Rumpel'
O A
OA
Perova
A V
AV
Pakhomova
A V
AV
Poluektova
M E
ME
D000014:Abnormalities, Drug-Induced; D000818:Animals; D000831:Animals, Newborn; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D005260:Female; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D017239:Paclitaxel / Q000633:toxicity*; D011247:Pregnancy; D011270:Pregnancy, Animal; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel