title: Composition and biological activity of the essential oil from leaves of Plinia cerrocampanensis, a new source of alpha-bisabolol.
abstract: The essential oil from fresh leaves of Plinia cerrocampanensis Barrie (Myrtaceae), obtained by hydrodistillation, was analysed by GC-FID and GC-MS. Forty components, representing more than 91% of the oil, were identified. Oxygenated sesquiterpenes represented the main fraction with alpha-bisabolol (42.8%) as the major constituent, making this plant a new and good source of this substance. Biological activity of the essential oil was evaluated against several bacterial and fungal strains as well as larvae from Aedes aegypti. The highest activity was found against Staphylococcus aureus, Pseudomonas aeruginosa, Microsporum gypseum, Trichophyton mentagrophytes and Trichophyton rubrum with MIC values from 32 to 125 microg/ml. The essential oil also showed potent inhibitory and bactericidal activities against three H. pylori strains, with MIC and MBC values of 62.5 microg/ml, and caused 100% mortality of A. aegypti larvae at a concentration of 500 microg/ml.
authors.affiliation: Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain.
authors.forename: Roser
authors.initials: R
authors.lastname: Vila
authors.forename: Ana Isabel
authors.initials: AI
authors.lastname: Santana
authors.forename: Renato
authors.initials: R
authors.lastname: Pérez-Rosés
authors.forename: Anayansi
authors.initials: A
authors.lastname: Valderrama
authors.forename: M Victoria
authors.initials: MV
authors.lastname: Castelli
authors.forename: Sergio
authors.initials: S
authors.lastname: Mendonca
authors.forename: Susana
authors.initials: S
authors.lastname: Zacchino
authors.forename: Mahabir P
authors.initials: MP
authors.lastname: Gupta
authors.forename: Salvador
authors.initials: S
authors.lastname: Cañigueral
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D007814:Larva / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D000081222:Monocyclic Sesquiterpenes; D027822:Myrtaceae / Q000737:chemistry*; D009822:Oils, Volatile / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D018515:Plant Leaves / Q000737:chemistry*; D012717:Sesquiterpenes / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000081222:Monocyclic Sesquiterpenes; D009822:Oils, Volatile; D012717:Sesquiterpenes; C004497:bisabolol