Postnatal hyperoxia and the developing rat retina: beyond the obvious vasculopathy.
Although a great deal of emphasis has been placed on the vasculopathy that is associated with oxygen-induced retinopathy (OIR), our studies also revealed significant and irreversible structural (retinal histology) and functional (scotopic and photopic electroretinograms) impairments that were significantly more severe in pigmented Long-Evans rats compared to the more commonly used albino Sprague Dawley rats. In the following pages, we will highlight what we have learned about the retinal pathophysiological processes of OIR taking place in strains of both rats with the hope that this will trigger investigations into new therapeutic strategies to complement those geared at preventing the vasculopathy.
Dorfman
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Department of Pharmacology and Therapeutics, McGill University-Montreal Children's Hospital Research Institute, Montréal, QC, Canada.
Chemtob
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Lachapelle
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D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D004596:Electroretinography; D006801:Humans; D018496:Hyperoxia / Q000503:physiopathology*; D007231:Infant, Newborn; D010100:Oxygen / Q000633:toxicity; D051381:Rats; D012160:Retina / Q000503:physiopathology*; D015861:Retinal Neovascularization / Q000503:physiopathology*; D012171:Retinal Vessels / Q000187:drug effects; D012178:Retinopathy of Prematurity / Q000503:physiopathology*
D010100:Oxygen