title: Protein arginine methylation in estrogen signaling and estrogen-related cancers.
abstract: Estrogen signaling pathways regulate multiple cellular processes including proliferation and differentiation, and dysregulation of these pathways underlies several human pathologies. Post-translational modifications (PTMs) play an important role in estrogen signaling. This review focuses on recent findings pertinent to arginine methylation of non-histone proteins and their implications in estrogen signaling. We describe protein arginine methyltransferases and demethylases, the role of methylarginine proteins in estrogen action and crosstalk with other PTMs such as phosphorylation and lysine methylation. The relationships between various PTMs form a specific code that is likely to play an important role in hormone signaling. In addition, dysregulation of arginine methylation or of enzymes responsible for these modifications could be key events in estrogen-dependent cancers such as breast cancer.
authors.affiliation: INSERM U554, Montpellier 34090, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Teyssier
authors.forename: Muriel
authors.initials: M
authors.lastname: Le Romancer
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Sentis
authors.forename: Stéphan
authors.initials: S
authors.lastname: Jalaguier
authors.forename: Laura
authors.initials: L
authors.lastname: Corbo
authors.forename: Vincent
authors.initials: V
authors.lastname: Cavaillès
mesh_terms: D000818:Animals; D001120:Arginine / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008745:Methylation; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism*; D011484:Protein-Arginine N-Methyltransferases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D004967:Estrogens; D011960:Receptors, Estrogen; D001120:Arginine; D011484:Protein-Arginine N-Methyltransferases