Determinants of kidney dysfunction: is vasopressin a new player in the arena?
Copeptin is a marker of endogenous vasopressin secretion. Population-based data of the PREVEND Study show that men and women with high plasma copeptin have a highly prevalent microalbuminuria in addition to the low level of hydration typical of persons with high vasopressin secretion. The association of plasma copeptin with microalbuminuria suggests that vasopressin might have a role in kidney dysfunction via effects on the permselectivity of the glomerulus and/or on tubular albumin reabsorption.
Cirillo
Massimo
M
D000419:Albuminuria / Q000150:complications; D015415:Biomarkers / Q000097:blood; D005260:Female; D006020:Glycopeptides / Q000097:blood; D006801:Humans; D008297:Male; D051437:Renal Insufficiency / Q000453:epidemiology / Q000209:etiology*; D014667:Vasopressins / Q000378:metabolism* / Q000502:physiology
D015415:Biomarkers; D006020:Glycopeptides; C048197:copeptins; D014667:Vasopressins