Efficient one-pot synthesis of 2,4-di(het)aryl and 2,4-diamino pyrido[3,2-d]pyrimidines involving regioselective S(N)Ar and palladium-catalyzed reactions.
An efficient and original synthesis of various 2,4-disubstituted pyrido[3,2-d]pyrimidines is reported. One-pot di(het)arylation and diamination approaches were used to obtain highly functionalized products in very good yields. The two one-pot processes were compared to their step-by-step related synthesis. Both routes started from 2,4-dichloropyrido[3,2-d]pyrimidine and included a chlorine discrimination during the first reaction.
Tikad
Abdellatif
A
Institut de Chimie Organique et Analytique, (1) Université d'Orléans, (2) CNRS UMR 6005, B.P. 6759, 45067, Orléans Cedex 2, France.
Routier
Sylvain
S
Akssira
Mohamed
M
Guillaumet
Gérald
G
D000586:Amination; D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis*
D006841:Hydrocarbons, Aromatic; D011743:Pyrimidines; D010165:Palladium