Increased plasma n-3 polyunsaturated fatty acid is associated with improved insulin sensitivity in type 2 diabetes in China.
Increased tissue n-3 polyunsaturated fatty acid (PUFA) is associated with improved insulin sensitivity in type 2 diabetes. However, this relationship among Chinese is not clear. To investigate the relationship between plasma phospholipids (PL) fatty acid composition and insulin resistance (IR) in type 2 diabetes mellitus, 186 type 2 diabetes and 180 healthy subjects were studied in this case-control study. In the sex, age and BMI controlled partial correlation, homeostasis model assessment (HOMA)-IR and blood glucose was significantly negatively correlated with plasma PL n-3 PUFA, 20:5n-3 and ratio of n-3:n-6 (p<0.01), and positively correlated with n-6 PUFA (p<0.001) and saturated fatty acid (p<0.05) in the diabetes patients. PL 22:6n-3 was also significantly negatively correlated with HOMA-IR (p<0.01), but not with blood glucose. Fasting insulin was significantly negatively correlated with plasma PL n-3 PUFA, 20:5n-3, 22:6n-3 and ratio of n-3:n-6 (p<0.01). The 18:3n-3 was not associated with HOMA-IR and fasting insulin. The results suggested that increased plasma PL n-3 PUFA, 20:5n-3, 22:6n-3 and ratio of n-3:n-6 PUFA was associated with decreased HOMA-IR in type 2 diabetes. Increased plasma PL n-3 PUFA improves insulin sensitivity in type 2 diabetes.
Huang
Tao
T
Department of Food Science and Nutrition, Zhejiang University, Hangzhou, P. R. China.
Wahlqvist
Mark L
ML
Xu
Tongcheng
T
Xu
Amei
A
Zhang
Aizhen
A
Li
Duo
D
D000368:Aged; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D002681:China; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D007328:Insulin; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol