Insulin-dependent signaling: regulation by amino acids and energy.
Recent research has indicated that amino acids stimulate a signal-transduction pathway that is also used by insulin. Moreover, for insulin to exert its anabolic and anticatabolic effects on protein, there is an absolute requirement for amino acids. This signaling pathway becomes inhibited by adenosine monophosphate-activated protein kinase when energy production falls short. In this brief review some of the experimental evidence is discussed.
Meijer
A J
AJ
Department of Biochemistry, Academic Medical Center, Amsterdam, The Netherlands.