title: Poxviruses taking a ride on actin: new users of known hardware.
abstract: Vaccinia virus uses A36 to recruit the actin polymerization effectors Nck and N-WASP to drive actin tail formation. Now, Dodding and Way identify functional orthologs of A36 in other vertebrate poxviruses that harbor varying numbers of Nck-binding sites and can substitute for A36 despite no sequence homology.
authors.affiliation: Cytoskeleton Dynamics Group, Helmholtz Centre for Infection Research, Inhoffen Strasse 7, 38124 Braunschweig, Germany. klemens.rottner@helmholtz-hzi.de
authors.forename: Klemens
authors.initials: K
authors.lastname: Rottner
authors.forename: Theresia E B
authors.initials: TE
authors.lastname: Stradal
mesh_terms: D000199:Actins / Q000378:metabolism*; D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D011212:Poxviridae / Q000235:genetics / Q000378:metabolism*; D011213:Poxviridae Infections / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal / Q000235:genetics / Q000378:metabolism*
chemical_list: D000199:Actins; D048868:Adaptor Proteins, Signal Transducing; C078332:Nck protein; D015513:Oncogene Proteins; D014764:Viral Proteins; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal