title: Recommendations for research priorities in breast cancer by the coalition of cancer cooperative groups scientific leadership council: imaging and local therapy.
abstract: Imaging and local therapy are important modalities for detection and management of localized breast cancer. Improvements in screening and local therapy have contributed to reduced breast cancer-associated morbidity and mortality. The Coalition of Cancer Cooperative Groups (CCCG) convened the Scientific Leadership Council (SLC) in breast cancer, an expert panel, to identify priorities for future research and current trials with greatest practice-changing potential. Panelists formed a consensus on research priorities for breast imaging and locoregional therapy, and also identified six trials judged to be of high priority. Current high priority trials included trials determining: (1) the role of accelerated partial breast versus whole-breast radiation (B39), (2) the feasibility, safety, and local and systemic control of small localized breast cancers treated with tumor ablation (Z1072), (3) the role of removal of the primary cancer in selected patients with metastatic disease (E2108), and (4) the clinical and biological effects of pre-operative anti-HER2-directed and ER-directed therapies in localized or locally advanced breast cancer (B41, Z1031, Z1041). Ongoing and future trials will further refine optimal locoregional management, and additional research is required to develop improved screening methods and identify high risk populations most likely to benefit from targeted screening.
authors.affiliation: Montefiore Medical Center - Weiler Division, Professor of Medicine and Women's Health, Albert Einstein College of Medicine, 1825 Eastchester Road, 10461, Bronx, NY, USA. jsparano@montefiore.org
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Sparano
authors.forename: Etta D
authors.initials: ED
authors.lastname: Pisano
authors.forename: Julia R
authors.initials: JR
authors.lastname: White
authors.forename: Kelly K
authors.initials: KK
authors.lastname: Hunt
authors.forename: Eleftherios P
authors.initials: EP
authors.lastname: Mamounas
authors.forename: Edith A
authors.initials: EA
authors.lastname: Perez
authors.forename: Gabriel N
authors.initials: GN
authors.lastname: Hortobagyi
authors.forename: Julie R
authors.initials: JR
authors.lastname: Gralow
authors.forename: Robert L
authors.initials: RL
authors.lastname: Comis
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D012106:Research