title: Long-term functional outcome and quality of life after restorative proctocolectomy with ileo-anal anastomosis for colitis.
abstract: OBJECTIVE
  The study aimed to evaluate long-term health-related quality of life (HRQOL) and functional outcome in patients who had undergone restorative proctocolectomy with ileo-anal anastomosis (IPAA) for ulcerative colitis and familial adenomatous polyposis.
  
  
  METHODS
  A total of 156 patients who underwent IPAA during the period 1984-2003 and who still had an intact pouch were included. The HRQOL score was compared with 4152 individuals from the general Norwegian population using the SF-36 questionnaire, and function was evaluated using the Wexner Continence Grading Scale.
  
  
  RESULTS
  One hundred and ten (71%) patients answered the questionnaires, 60 (55%) of whom were men. All except five patients had ulcerative colitis. Median (range) age at interview was 47 (19-66) years, and time after surgery was 12 (2-22) years. The IPAA patients scored slightly, but significantly, lower in four of six SF-36 health domains than the control subjects, adjusted for age and gender. Multiple regression analysis showed frequency of nocturnal defaecation, faecal incontinence and urgency to be independent negative prognostic factors of quality of life. Frequency of defaecation was a median of 7 (3-12) bowel movements during the day and 2 (0-6) at night. The majority had some degree of faecal incontinence, median (range) Wexner score of 8 (0-17), and 40% reported urgency of defaecation necessitating alterations in lifestyle.
  
  
  CONCLUSIONS
  Patients with IPAA reported slightly lower HRQOL rates than the general population and had an inferior functional outcome.
authors.affiliation: Department of Gastrointestinal Surgery, Oslo University Hospital, Aker, Norway.
authors.forename: T
authors.initials: T
authors.lastname: Andersson
authors.forename: O C
authors.initials: OC
authors.lastname: Lunde
authors.forename: E
authors.initials: E
authors.lastname: Johnson
authors.forename: T
authors.initials: T
authors.lastname: Moum
authors.forename: A
authors.initials: A
authors.lastname: Nesbakken
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000523:psychology* / Q000601:surgery*; D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical; D003093:Colitis, Ulcerative / Q000523:psychology* / Q000601:surgery*; D003672:Defecation; D005242:Fecal Incontinence / Q000209:etiology; D005260:Female; D006801:Humans; D007082:Ileum / Q000601:surgery*; D007415:Intestinal Obstruction / Q000209:etiology; D008297:Male; D008875:Middle Aged; D019449:Pouchitis / Q000209:etiology; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*; D011788:Quality of Life; D012007:Rectum / Q000601:surgery*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome