title: H1-antihistamines and oxidative burst of professional phagocytes.
abstract: OBJECTIVE
  We analysed and compared the effect of five H1-antihistamines on stimulated oxidative burst at extra- and intracellular level of isolated and stimulated human polymorphonuclear leukocytes.
  
  
  METHODS
  Oxidative burst of isolated human neutrophils was studied by means of luminol and isoluminol enhanced chemiluminescence.
  
  
  RESULTS
  The following rank order of potency for H1-antihistamines to decrease chemiluminescence was evaluated extracellularly: dithiaden> loratadine> chlorpheniramine> brompheniramine> pheniramine and at intracellular site: loratadine> dithiaden.
  
  
  CONCLUSIONS
  H1-antihistamines differ substantially according to their chemical structure in suppressing oxidative burst both at extra- and intracellular site of isolated stimulated human neutrophils.
authors.affiliation: Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Bratislava, Slovakia. exfarano@savba.sk
authors.forename: Radomir
authors.initials: R
authors.lastname: Nosal
authors.forename: Katarina
authors.initials: K
authors.lastname: Drabikova
authors.forename: Viera
authors.initials: V
authors.lastname: Jancinova
authors.forename: Jana
authors.initials: J
authors.lastname: Moravcova
authors.forename: Antonin
authors.initials: A
authors.lastname: Lojek
authors.forename: Milan
authors.initials: M
authors.lastname: Ciz
authors.forename: Tatiana
authors.initials: T
authors.lastname: Macickova
authors.forename: Jana
authors.initials: J
authors.lastname: Pecivova
mesh_terms: D001582:Benzothiepins / Q000494:pharmacology; D001977:Brompheniramine / Q000494:pharmacology; D002744:Chlorpheniramine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005110:Extracellular Space / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D042541:Intracellular Space / Q000187:drug effects; D017336:Loratadine / Q000494:pharmacology; D049449:Luminescence; D008165:Luminol / Q000031:analogs & derivatives; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010632:Pheniramine / Q000494:pharmacology; D016897:Respiratory Burst / Q000187:drug effects*
chemical_list: D001582:Benzothiepins; D006634:Histamine H1 Antagonists; D010632:Pheniramine; C032487:isoluminol; D002744:Chlorpheniramine; C100170:dithiadene; D008165:Luminol; D017336:Loratadine; D001977:Brompheniramine