[Expression of monocyte chemoattractant protein-1 in sudden death due to viral myocarditis and its medicolegal significance].
OBJECTIVE
To explore the expression and significance of monocyte chemoattractant protein-1 (MCP-1) in myocardium in sudden death caused by viral myocarditis (VMC).


METHODS
To investigate the expression of MCP-1 in VMC sudden death group and control group using improved immunohistochemical technique and to compare the difference of the expression of MCP-1 between two groups with statistical method.


RESULTS
In VMC sudden death group, MCP-1 was positively expressed in 17 of 20 cases. While only 4 of the 20 cases in the control group showed a mildly positive expression sparsely in myocardium, and the rest cases were completely negative. The rate of positive expression of MCP-1 in VMC group was obviously higher than that of the control group (P<0.01).


CONCLUSIONS
The expression of MCP-1 detected by immunohistochemistry provides an objective morphologic evidence for the diagnosis of VMC sudden death in forensic pathology.
Ning
Juan
J
Department of Forensic Pathology, Wannan Medical College, Wuhu, China. ningjuan67826@126.com
Li
Yong-Hong
YH
Zhang
Chun-Bing
CB
D000293:Adolescent; D000328:Adult; D000368:Aged; D001344:Autopsy; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D016757:Death, Sudden, Cardiac; D005260:Female; D049429:Forensic Pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D013194:Staining and Labeling; D055815:Young Adult
C111835:CCL2 protein, human; D018932:Chemokine CCL2