Comparison of rimonabant and sibutramine treatment effects on food compulsion in rats.
OBJECTIVE
To compare the therapeutic effect of rimonabant, a new drug which is a selective antagonist of CB1 receptors, with the sibutramine.


METHODS
It is an experimental clinical trial, prospective, placebo controlled. Our test was performed in 38 rats, adults females with a hyper caloric diet. We collected their blood 3 times and weighted them once a week. We divided the rats in 3 groups: Rimonabant, Sibutramine and Control. Statistic analysis has been made through ANOVA test, Tukey test and t Student test.


RESULTS
The Rimonabant group demonstrated a significant reduction of the weight increase in rats. The Sibutramine group showed a significant reduction on blood glycemia compared to Rimonabant group and Control group.


CONCLUSIONS
Rimonabant showed to be more effective than Sibutramine by decreasing weight gain. Sibutramine has been more effective than Rimonabant and Control groups by decreasing the blood glycemia.
Menezes
Honório Sampaio
HS
Instituto de Cardiologia do Rio Grande do Sul/FUC, Av. Princesa Isabel 370, Porto Alegre, RS, Brazil. hsmenezes@computech.com.br
Ciulla
Verônica
V
Camargo
Paulo Sampaio
PS
Correa
Cora Albrecht
CA
Oliveira
Tatiana Medina Costa de
TM
D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects*; D003192:Compulsive Behavior / Q000378:metabolism; D003503:Cyclobutanes / Q000494:pharmacology*; D004041:Dietary Fats / Q000008:administration & dosage*; D004812:Epidemiologic Methods; D005260:Female; D023421:Models, Animal; D010880:Piperidines / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000077285:Rimonabant; D015430:Weight Gain / Q000187:drug effects
D001067:Appetite Depressants; D001786:Blood Glucose; D003503:Cyclobutanes; D004041:Dietary Fats; D010880:Piperidines; D011720:Pyrazoles; D000077285:Rimonabant; C058254:sibutramine