title: CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer.
abstract: OBJECTIVE
  To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer.
  
  
  METHODS
  Forty-three Israeli Jewish women with cervical cancer and 123 healthy Israeli Jewish women were assessed. CYP1A1 (2 alleles) and CYP2D6 polymorphism was analyzed using an allele-specific, polymerase chain reaction-based method.
  
  
  RESULTS
  The allele frequency and genotype distribution for the CYP1A1 (2 alleles) and CYP2D6 polymorphism did not reach a level of significance. Smoking was the only independent risk factor for cervical cancer (P = 0.0003).
  
  
  CONCLUSIONS
  CYP1A1 and CYP2D6 mutations are not related to an increased risk for cervical cancer in the Jewish Israeli population.
authors.affiliation: Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.
authors.forename: Guy
authors.initials: G
authors.lastname: Gutman
authors.forename: Tova
authors.initials: T
authors.lastname: Morad
authors.forename: Ben
authors.initials: B
authors.lastname: Peleg
authors.forename: Chavah
authors.initials: C
authors.lastname: Peretz
authors.forename: Amiram
authors.initials: A
authors.lastname: Bar-Am
authors.forename: Tamar
authors.initials: T
authors.lastname: Safra
authors.forename: Dan
authors.initials: D
authors.lastname: Grisaru
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007557:Israel; D007585:Jews / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: D019363:Cytochrome P-450 CYP1A1; D019389:Cytochrome P-450 CYP2D6