Toxic nuclear effects of the organophosphorus insecticide Dichlorvos (DDVP) in human peripheral blood lymphocytes.
Organophosphorus insecticides are used worldwide in the control of agricultural, household and veterinary pests. Dichlorvos (2,2-dichlorovinyl dimethyl phosphate) is a commonly used organophosphorus insecticide. In this study, in order to elucidate the toxic nuclear effects of dichlorvos, freshly isolated human peripheral blood lymphocytes were incubated with 5, 10, 20, 40, 80 and 100 microg/mL of dichlorvos. According to the results, dichlorvos induced micronuclei, decreased the mitotic and replication indexes. It is a genotoxic product causing chromosomal damage (an increase in micronucleus) and cell death (decrease in mitotic and replication indexes).
Eroğlu
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HE
Bozok University Department of Biology, Faculty of Science and Art Yozgat Turkey. herhan.eroglu@bozok.edu.tr
D016923:Cell Death / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects* / Q000473:pathology*; D002478:Cells, Cultured; D002875:Chromosomes / Q000187:drug effects; D004006:Dichlorvos / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007306:Insecticides / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D008938:Mitosis / Q000187:drug effects
D007306:Insecticides; D004006:Dichlorvos