Biocatalytic carboxylation.
Dwindling petroleum feedstocks and increased CO(2)-concentrations in the atmosphere currently open the concept of using CO(2) as raw material for the synthesis of well-defined organic compounds. In parallel to recent advances in the chemical CO(2)-fixation, enzymatic (biocatalytic) carboxylation is currently being investigated at an increased pace. On the one hand, this critical review provides a concise overview on highly specific biosynthetic pathways for CO(2)-fixation and, on the other hand, a summary of biodegradation (detoxification) processes involving enzymes which possess relaxed substrate specificities, which allow their application for the regioselective carboxylation of organic substrates to furnish the corresponding carboxylic acids (145 references).
Glueck
Silvia M
SM
Research Centre Applied Biocatalysis, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria.
Gümüs
Selcuc
S
Fabian
Walter M F
WM
Faber
Kurt
K
D000818:Animals; D055162:Biocatalysis; D001673:Biodegradation, Environmental; D002245:Carbon Dioxide / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D002264:Carboxylic Acids / Q000737:chemistry / Q000378:metabolism*; D013816:Thermodynamics
D002264:Carboxylic Acids; D002245:Carbon Dioxide