title: Synthesis and antitumor activity of new dihydropyridine thioglycosides and their corresponding dehydrogenated forms.
abstract: A number of a new pyridine thioglycosides were synthesized via reaction of piperidinium salts of dihydropyridinethiones with 2,3,4,6-tetra-O-acetyl-alpha-D-gluco- and galactopyranosyl bromide. The antitumor activities of the synthesized compounds were evaluated utilizing two different human cell lines. Some of the tested compounds showed high inhibition of human cell lines. The detailed synthesis, spectroscopic data and antitumor activities for the synthesized compounds were reported.
authors.affiliation: Photochemistry Department, National research center, Dokki, 12622 Cairo, Egypt. hebanrc@yahoo.com
authors.forename: Hebat-Allah S
authors.initials: HA
authors.lastname: Abbas
authors.forename: Wael A
authors.initials: WA
authors.lastname: El Sayed
authors.forename: Nahed M
authors.initials: NM
authors.lastname: Fathy
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006865:Hydrogenation; D008297:Male; D051379:Mice; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D013865:Thioglycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D004095:Dihydropyridines; D013865:Thioglycosides