title: POEMS syndrome complicated by follicular lymphoma.
abstract: A 59-year-old woman presented with ascites and intraperitoneal lymph node swelling. Pathological examination of the lymph node revealed follicular lymphoma. After a lymph node biopsy, she developed atypical genital bleeding, multiple endocrine disorders, polyneuropathy with a high plasma level of vascular endothelial growth factor (VEGF), and was diagnosed with POEMS syndrome. Following administration of methyl prednisolone, ascites immediately decreased and her performance status improved; however, about 18 months later, renal failure occurred, and she died despite increased steroid dosage. Lymph node swelling is often found in POEMS syndrome; however, its histological appearance is not well known, and it is very rare to be concomitant with malignant lymphoma. Therefore, it is important to perform a lymph node biopsy and investigate it in relation with VEGF.
authors.affiliation: Department of Internal Medicine, Kushiro Rosai Hospital.
authors.forename: Takahide
authors.initials: T
authors.lastname: SASAKI
authors.forename: Shunsuke
authors.initials: S
authors.lastname: OHNISHI
authors.forename: Reizo
authors.initials: R
authors.lastname: ONISHI
authors.forename: Ryou
authors.initials: R
authors.lastname: TAKEMURA
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: KOBAYASHI
authors.forename: Mio
authors.initials: M
authors.lastname: SUZUKI
authors.forename: Masayoshi
authors.initials: M
authors.lastname: DAZAI
authors.forename: Tamotsu
authors.initials: T
authors.lastname: HATA
authors.forename: Junji
authors.initials: J
authors.lastname: YAMAMOTO
authors.forename: Hisashi
authors.initials: H
authors.lastname: ODA
authors.forename: Tatsuro
authors.initials: T
authors.lastname: TAKAHASHI
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: OGASAWARA
authors.forename: Takuto
authors.initials: T
authors.lastname: MIYAGISHIMA
mesh_terms: D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008224:Lymphoma, Follicular / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D008875:Middle Aged; D016878:POEMS Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D015415:Biomarkers; D042461:Vascular Endothelial Growth Factor A; D011239:Prednisolone