Allelic polymorphism of cytokine genes during pulmonary tuberculosis.
Modern immunological and molecular genetic studies showed that tuberculosis is accompanied by an imbalance in the production of immunoregulatory cytokines by mononuclear leukocytes. T allele and homozygous TT genotype of T-330G polymorphism in the IL2 gene, T allele and TT genotype of C-590T polymorphism in the IL4 gene, and CC genotype of A-1188C polymorphism in the IL12B gene are immunogenetic factors that have protective activity against susceptibility to pulmonary tuberculosis. Susceptibility to tuberculous infection is associated with A1A2 genotype of the polymorphic region +3953 A1/A2 in the IL1B gene; G allele and TG and GG genotypes of T-330G polymorphism in the IL2 gene; C allele and CC and CT genotypes of C-590T polymorphism in the IL4 gene; and AC genotype of the polymorphic region A-1188C in the IL12 gene.
Naslednikova
I O
IO
Department of Pathophysiology, Department of Phthisiology and Pulmonology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russia. ira_naslednikova@mail.ru
Urazova
O I
OI
Voronkova
O V
OV
Strelis
A K
AK
Novitsky
V V
VV
Nikulina
E L
EL
Hasanova
R R
RR
Kononova
T E
TE
Serebryakova
V A
VA
Vasileva
O A
OA
Suhalentseva
N A
NA
Churina
E G
EG
Kolosova
A E
AE
Fedorovich
T V
TV
D000328:Adult; D000483:Alleles; D016207:Cytokines / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics; D053583:Interleukin-1beta / Q000235:genetics; D007376:Interleukin-2 / Q000235:genetics; D015847:Interleukin-4 / Q000235:genetics; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
D016207:Cytokines; D053583:Interleukin-1beta; D007376:Interleukin-2; D018664:Interleukin-12; D015847:Interleukin-4