Separation anxiety: detachment from the extracellular matrix induces metabolic changes that can stimulate tumorigenesis.
One of the earliest stages of tumor progression involves the ability of cells to survive and proliferate when not attached to the extracellular matrix (ECM). New research using a physiologically relevant breast cancer model reveals how separation from the ECM stimulates metabolic changes characteristic of developing tumors.
Cichon
Magdalena A
MA
Mayo Clinic Cancer Center, Jacksonville, FL 32225, USA.
Radisky
Derek C
DC
D001943:Breast Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D002460:Cell Line; D002470:Cell Survival; D018450:Disease Progression; D005109:Extracellular Matrix / Q000378:metabolism*; D005260:Female; D006801:Humans; D009857:Oncogenes; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species