title: HIV and tuberculosis in Durban, South Africa: adherence to two medication regimens.
abstract: Given that antiretroviral (ARV) medication adherence has been shown to be high in resource-limited countries, the question remains as to whether adherence will remain at that level as medications become more widely available. Comparing adherence to tuberculosis (TB) medications, which have been readily available, and ARV medications may help to indicate the likely future adherence to ARVs as access to these medications becomes more widespread. This study examined sense of coherence, social support, symptom status, quality of life, and adherence to medications in two samples of individuals being treated either for TB or human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) at clinics in Durban, South Africa. Findings revealed the distinctive socio-economic backgrounds of the two cohorts. Although there were significant differences with regard to the psychosocial variables, there were no significant differences by the two samples in adherence to medications as well as adherence to appointments. Given the self-selected nature of the participants in this study, namely those able to attend clinic, as well as those likely to be adherent to ARVs, there is every reason for caution in the interpretations of these findings. As access to ARV medications becomes more widely available in South Africa, the question remains as to whether such high adherence will be maintained given the constraints of access to food and other basic necessities.
authors.affiliation: Graduate Program in Nursing, MGH Institute of Health Professions, Boston, MA, USA. icorless@mghihp.edu
authors.forename: Inge B
authors.initials: IB
authors.lastname: Corless
authors.forename: Dean
authors.initials: D
authors.lastname: Wantland
authors.forename: Busi
authors.initials: B
authors.lastname: Bhengu
authors.forename: Patricia
authors.initials: P
authors.lastname: McInerney
authors.forename: Busi
authors.initials: B
authors.lastname: Ncama
authors.forename: Patrice K
authors.initials: PK
authors.lastname: Nicholas
authors.forename: Chris
authors.initials: C
authors.lastname: McGibbon
authors.forename: Emily
authors.initials: E
authors.lastname: Wong
authors.forename: Sheila M
authors.initials: SM
authors.lastname: Davis
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000627:therapeutic use*; D001071:Appointments and Schedules; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012944:Social Support; D013019:South Africa; D014376:Tuberculosis / Q000188:drug therapy*; D055815:Young Adult; D016903:Drug Monitoring
chemical_list: D019380:Anti-HIV Agents; D000995:Antitubercular Agents