title: Rab3 GTPase lands Bruchpilot.
abstract: Active zones are the sites of neurotransmitter release, but their assembly mechanisms are poorly understood. In this issue of Neuron, Graf et al. perform a genetic screen in Drosophila and uncover a novel role for the Rab3 GTPase in organizing the active zone at the neuromuscular junction.
authors.affiliation: Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Giagtzoglou
authors.forename: Timothy
authors.initials: T
authors.lastname: Mahoney
authors.forename: Chi-Kuang
authors.initials: CK
authors.lastname: Yao
authors.forename: Hugo J
authors.initials: HJ
authors.lastname: Bellen
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism*; D020558:GTP Phosphohydrolases / Q000235:genetics / Q000378:metabolism; D009469:Neuromuscular Junction / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure; D017729:Presynaptic Terminals / Q000378:metabolism* / Q000648:ultrastructure; D015398:Signal Transduction / Q000502:physiology; D020692:rab3 GTP-Binding Proteins / Q000378:metabolism*
chemical_list: C510146:BRP protein, Drosophila; D029721:Drosophila Proteins; D020558:GTP Phosphohydrolases; C000607807:Rab3 protein, Drosophila; D020692:rab3 GTP-Binding Proteins; D002118:Calcium