Ectopic calcification as discernible manifestation in neonates with pseudohypoparathyroidism type 1a.
The diagnosis of pseudohypoparathyroidism type 1a (PHP1a) is challenging, because both the osteodystrophy, such as brachydactyly and round face, and the symptomatic hypocalcemia usually develop beyond infancy. Although ectopic calcification may be an early sign of PHP1a, there are no systematic reviews regarding the time of its appearance. We here report on two PHP1a patients who presented with subcutaneous calcification in neonatal period.
Adachi
Masanori
M
Department of Endocrinology & Metabolism, Clinical Research Institute, Kanagawa Children's Medical Center, Yokohama 232-8555, Japan.
Muroya
Koji
K
Asakura
Yumi
Y
Kondoh
Yoichi
Y
Ishihara
Jun
J
Hasegawa
Tomonobu
T