Neuroprotective activity of Matricaria recutita Linn against global model of ischemia in rats.
BACKGROUND
Traditionally, the whole plant is used for various diseases, including neuronal disorders.


OBJECTIVE
To evaluate the neuroprotective effect of Matricaria recutita L. against global cerebral ischemia/reperfusion (I/R) injury-induced oxidative stress in rats.


METHODS
Neuroprotective activity was carried out by global cerebral ischemia on Sprague-Dawley rats by bilateral carotid artery (BCA) occlusion for 30 min followed by 60 min reperfusion. The antioxidant enzymatic and non-enzymatic levels were estimated along with cerebral infarction area and histopathological studies.


RESULTS
The Matricaria recutita L. methanolic extract showed dose-dependent neuroprotective activity by significant decrease in lipid peroxidation (LPO) and increase in the superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and total thiol levels in extract treated groups as compared to ischemia/reperfusion group. Cerebral infarction area was significantly reduced in extract treated groups as compared to ischemia/reperfusion group.


CONCLUSIONS
The methanolic extract of Matricaria recutita L. showed potent neuroprotective activity against global cerebral ischemia/reperfusion injury-induced oxidative stress in rats.
Chandrashekhar
V M
VM
Department of Pharmacology, Hanagal Shri Kumareshawr College of Pharmacy, BVVS campus, Bagalkot-587101, Karnataka, India. chandupharm@yahoo.com
Ranpariya
V L
VL
Ganapaty
S
S
Parashar
A
A
Muchandi
A A
AA
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism; D002544:Cerebral Infarction / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004798:Enzymes / Q000378:metabolism; D005260:Female; D056626:Inflorescence; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D031168:Matricaria; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control
D000975:Antioxidants; D004798:Enzymes; D018696:Neuroprotective Agents; D010936:Plant Extracts