Current state of coenzyme Q(10) production and its applications.
Coenzyme Q(10) (CoQ(10)), an obligatory cofactor in the aerobic respiratory electron transfer for energy generation, is formed from the conjugation of a benzoquinone ring with a hydrophobic isoprenoid chain. CoQ(10) is now used as a nutritional supplement because of its antioxidant properties and is beneficial in the treatment of several human diseases when administered orally. Bioprocesses have been developed for the commercial production of CoQ(10) because of its increased demand, and these bioprocesses depend on microbes that produce high levels of CoQ(10) naturally. However, as knowledge of the biosynthetic enzymes and the regulatory mechanisms modulating CoQ(10) production increases, approaches arise for the genetic engineering of CoQ(10) production in Escherichia coli and Agrobacterium tumefaciens. This review focused on approaches for CoQ(10) production, strategies used to engineer CoQ(10) production in microbes, and potential applications of CoQ(10).
Jeya
Marimuthu
M
Department of Chemical Engineering, Konkuk University, Seoul 143-701, South Korea.
Moon
Hee-Jung
HJ
Lee
Jeong-Lim
JL
Kim
In-Won
IW
Lee
Jung-Kul
JK
D016960:Agrobacterium tumefaciens / Q000235:genetics / Q000378:metabolism*; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism; D019149:Bioreactors; D019587:Dietary Supplements; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D005285:Fermentation; D005818:Genetic Engineering; D006801:Humans; D007218:Industrial Microbiology; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry
D000975:Antioxidants; D014451:Ubiquinone; C024989:coenzyme Q10