Facile P,N-heterocycle synthesis via tandem aminomethylation-cyclization of H-phosphinate building blocks.
Various heterocycles containing phosphorus and nitrogen are easily synthesized from readily available H-phosphinate building blocks. Aminomethylation of these H-phosphinates is followed by in situ cyclization through substitution or cross-coupling to produce novel heterocycles in moderate to good yields.
Queffélec
Clémence
C
Department of Chemistry, TCU Box 298860, Texas Christian University, Fort Worth, TX 76129, USA.
Montchamp
Jean-Luc
JL
D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D010721:Phosphinic Acids / Q000737:chemistry*; D010758:Phosphorus / Q000737:chemistry
D006571:Heterocyclic Compounds; D010721:Phosphinic Acids; D010758:Phosphorus; D009584:Nitrogen