The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens.
Nine compounds isolated from the leaf and stem of Vitis amurensis Rupr. (Vitaceae) were evaluated for their antimicrobial activity against two oral pathogens, Streptococcus mutans and Streptococcus sanguis, which are associated with caries and periodontal disease, respectively. The results of several antimicrobial tests, including MIC, MBC, and TBAI, showed that three compounds inhibited the growth of the test bacteria at concentrations ranging from 12.5 to 50 microg/mL. Among these compounds, compound 5, trans-epsilon-viniferin, displayed the strongest activity against S. mutans and S. sanguis with MIC values of 25 and 12.5 microg/mL, respectively. This is the first report on the antimicrobial activity of stilbenes and oligostilbenes isolated from the leaf and stem of V. amurensis. Thus, this result suggests that natural antimicrobial compounds derived from V. amurensis may benefit oral health as plaque-control agents for the prevention of dental caries and periodontal disease.
Yim
NamHui
N
College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
Ha
Do Thi
do T
Trung
Trinh Nam
TN
Kim
Jin Pyo
JP
Lee
SangMyung
S
Na
MinkYeun
M
Jung
HyunJu
H
Kim
Hyun Su
HS
Kim
Young Ho
YH
Bae
KiHwan
K
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D003731:Dental Caries / Q000188:drug therapy / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D018515:Plant Leaves; D018547:Plant Stems; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development; D013298:Streptococcus sanguis / Q000187:drug effects* / Q000254:growth & development; D027843:Vitis
D000890:Anti-Infective Agents; D010936:Plant Extracts