title: Integrating clinical, community, and policy perspectives on human papillomavirus vaccination.
abstract: Infection with genital human papillomavirus (HPV) may cause anogenital cancers, oropharyngeal cancers, anogenital warts, and respiratory papillomas. Two prophylactic vaccines (a bivalent and a quadrivalent vaccine) are now licensed and currently in use in a number of countries. Both vaccines prevent infection with HPV-16 and HPV-18, which together cause approximately 70% of cervical cancers, and clinical trials have demonstrated 90%-100% efficacy in preventing precancerous cervical lesions attributable to HPV-16 and HPV-18. One vaccine also prevents HPV-6 and HPV-11, which cause 90% of genital warts. A growing literature describes psychosocial, interpersonal, organizational, and societal factors that influence HPV vaccination acceptability. This review summarizes the current literature and presents an integrated perspective, taking into account these diverse influences. The resulting integrated framework can be used as a heuristic tool for organizing factors at multiple levels to guide intervention development and future research.
authors.affiliation: School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA. Maria.E.Fernandez@uth.tmc.edu
authors.forename: María E
authors.initials: ME
authors.lastname: Fernández
authors.forename: Jennifer D
authors.initials: JD
authors.lastname: Allen
authors.forename: Ritesh
authors.initials: R
authors.lastname: Mistry
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Kahn
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003218:Condylomata Acuminata / Q000517:prevention & control; D003695:Delivery of Health Care; D005260:Female; D052140:Human papillomavirus 11 / Q000187:drug effects / Q000276:immunology; D052162:Human papillomavirus 16 / Q000187:drug effects / Q000276:immunology; D052161:Human papillomavirus 18 / Q000187:drug effects / Q000276:immunology; D052163:Human papillomavirus 6 / Q000187:drug effects / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D053918:Papillomavirus Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D010342:Patient Acceptance of Health Care; D011640:Public Policy; D014481:United States; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control; D055815:Young Adult
chemical_list: D053918:Papillomavirus Vaccines