[Clinical investigation of bisphosphonate-related osteonecrosis of the jaws].
We examined the clinical features of bisphosphonate(BP)-related osteonecrosis of the jaws(BRONJ), a serious complication resulting from intravenous BP treatment for multiple myeloma and malignant tumors with bone metastasis. We retrospectively reviewed the medical records of 36 patients who received intravenous BP therapy for the above-mentioned conditions, at Sapporo Medical University Hospital between July 2006 and October 2008. BP therapy caused BRONJ in 7 of 24 patients, but did not affect the bones of the other 17 patients. The other 12 of the 36 patients involved in the study were prescribed BP only after they had undergone an oral examination and treatment for dental inflammation. Of these patients, 7 developed BRONJ with BP treatment, after tooth extraction or acute dental inflammation. Treating dental inflammation before prescribing BP prevented the development of BRONJ. BRONJ is highly intractable and does not resolve with the standard treatment for osteomyelitis. Therefore, preventive therapy, which can be achieved by cooperation between medical doctors and dentists, is currently the most effective strategy for BRONJ. Conservative treatment with antibiotics may also be useful for maintaining or improving the quality of life of BRONJ patients.
Dehari
Hironari
H
Dept. of Oral Surgery, Sapporo Medical University School of Medicine.
Tomihara
Kei
K
Ueda
Megumi
M
Shimanishi
Makoto
M
Ono
Masayuki
M
Sasaki
Takanori
T
Igarashi
Tomohiro
T
Shiratori
Kaori
K
Abe
Masato
M
Ogi
Kazuhiro
K
Nakamori
Kenji
K
Miyazaki
Akihiro
A
Nagai
Itaru
I
Hiratsuka
Hiroyoshi
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy; D010020:Osteonecrosis / Q000139:chemically induced* / Q000517:prevention & control; D012189:Retrospective Studies
D050071:Bone Density Conservation Agents; D004164:Diphosphonates