title: Relapse of enterococcal prosthetic valve endocarditis with aortic root abscess following treatment with daptomycin in a patient not fit for surgery.
abstract: Daptomycin is a novel lipopeptide with activity against Gram-positive organisms including enterococci. It is licensed for the treatment of Staphylococcus aureus bacteraemia and right-sided endocarditis, but not endocarditis due to Enterococcus spp. We report a case of enterococcal prosthetic valve endocarditis with an aortic root abscess in an elderly patient who was not fit for surgery. The patient's endocarditis relapsed 9 weeks after a 6 week course of daptomycin.
authors.affiliation: Clinical Microbiology and Public Health Laboratory, Peterborough DistrictHospital, Thorpe Road, Peterborough PE3 6JW, UK.
authors.forename: D A
authors.initials: DA
authors.lastname: Enoch
authors.affiliation: Clinical Microbiology and Public Health Laboratory, Peterborough DistrictHospital, Thorpe Road, Peterborough PE3 6JW, UK.
authors.forename: N
authors.initials: N
authors.lastname: Phillimore
authors.affiliation: Clinical Microbiology and Public Health Laboratory, Peterborough DistrictHospital, Thorpe Road, Peterborough PE3 6JW, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Karas
authors.affiliation: Clinical Microbiology and Public Health Laboratory, Peterborough DistrictHospital, Thorpe Road, Peterborough PE3 6JW, UK.
authors.forename: L
authors.initials: L
authors.lastname: Horswill
authors.affiliation: Clinical Microbiology and Public Health Laboratory, Peterborough DistrictHospital, Thorpe Road, Peterborough PE3 6JW, UK.
authors.forename: D A
authors.initials: DA
authors.lastname: Mlangeni
mesh_terms: D000038:Abscess / Q000188:drug therapy / Q000209:etiology*; D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001021:Aortic Valve / Q000382:microbiology / Q000601:surgery*; D016470:Bacteremia / Q000188:drug therapy / Q000209:etiology*; D017576:Daptomycin / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000209:etiology*; D013293:Enterococcus faecalis / Q000187:drug effects / Q000302:isolation & purification*; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D012008:Recurrence
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D017576:Daptomycin