Discovery of a new and efficient small molecule for neuronal differentiation from mesenchymal stem cell.
A new synthetic small molecule, compound 1, which induced a neuronal differentiation from mesenchymal stem cells (MSCs) with an excellent efficiency, was identified. Furthermore the differentiated cell by 1 showed the neural electrophysiological and cholinergic neuron properties.
Kim
Na Ri
NR
Korea Research Institute of Chemical Technology, Daejeon, 305-600, Korea.
Kang
Seung Kyu
SK
Ahn
Hyun Hee
HH
Kwon
Sung Wook
SW
Park
Woul Seong
WS
Kim
Ki Suk
KS
Kim
Sung Soo
SS
Jung
Hee Jung
HJ
Choi
Sang Un
SU
Ahn
Jin Hee
JH
Kim
Kwang Rok
KR
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics; D002460:Cell Line; D055724:Electrophysiological Phenomena; D020869:Gene Expression Profiling; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D051381:Rats