title: Comparison of rimonabant and sibutramine treatment effects on food compulsion in rats.
abstract: OBJECTIVE
  To compare the therapeutic effect of rimonabant, a new drug which is a selective antagonist of CB1 receptors, with the sibutramine.
  
  
  METHODS
  It is an experimental clinical trial, prospective, placebo controlled. Our test was performed in 38 rats, adults females with a hyper caloric diet. We collected their blood 3 times and weighted them once a week. We divided the rats in 3 groups: Rimonabant, Sibutramine and Control. Statistic analysis has been made through ANOVA test, Tukey test and t Student test.
  
  
  RESULTS
  The Rimonabant group demonstrated a significant reduction of the weight increase in rats. The Sibutramine group showed a significant reduction on blood glycemia compared to Rimonabant group and Control group.
  
  
  CONCLUSIONS
  Rimonabant showed to be more effective than Sibutramine by decreasing weight gain. Sibutramine has been more effective than Rimonabant and Control groups by decreasing the blood glycemia.
authors.affiliation: Instituto de Cardiologia do Rio Grande do Sul/FUC, Av. Princesa Isabel 370, Porto Alegre, RS, Brazil. hsmenezes@computech.com.br
authors.forename: Honório Sampaio
authors.initials: HS
authors.lastname: Menezes
authors.forename: Verônica
authors.initials: V
authors.lastname: Ciulla
authors.forename: Paulo Sampaio
authors.initials: PS
authors.lastname: Camargo
authors.forename: Cora Albrecht
authors.initials: CA
authors.lastname: Correa
authors.forename: Tatiana Medina Costa de
authors.initials: TM
authors.lastname: Oliveira
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects*; D003192:Compulsive Behavior / Q000378:metabolism; D003503:Cyclobutanes / Q000494:pharmacology*; D004041:Dietary Fats / Q000008:administration & dosage*; D004812:Epidemiologic Methods; D005260:Female; D023421:Models, Animal; D010880:Piperidines / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000077285:Rimonabant; D015430:Weight Gain / Q000187:drug effects
chemical_list: D001067:Appetite Depressants; D001786:Blood Glucose; D003503:Cyclobutanes; D004041:Dietary Fats; D010880:Piperidines; D011720:Pyrazoles; D000077285:Rimonabant; C058254:sibutramine