title: Peroxisome proliferator-activated receptor gamma polymorphisms and coronary heart disease.
abstract: Single nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor gamma (PPARG) gene have been associated with cardiovascular risk factors, particularly obesity and diabetes. We assessed the relationship between 4 PPARG SNPs (C-681G, C-689T, Pro12Ala, and C1431T) and coronary heart disease (CHD) in the PRIME (249 cases/494 controls, only men) and ADVANCE (1,076 cases/805 controls, men or women) studies. In PRIME, homozygote individuals for the minor allele of the PPARG C-689T, Pro12Ala, and C1431T SNPs tended to have a higher risk of CHD than homozygote individuals for the frequent allele (adjusted OR [95% CI] = 3.43 [0.96-12.27], P = .058, 3.41 [0.95-12.22], P = .060 and 5.10 [0.99-26.37], P = .050, resp.). No such association could be detected in ADVANCE. Haplotype distributions were similar in cases and control in both studies. A meta-analysis on the Pro12Ala SNP, based on our data and 11 other published association studies (6,898 CHD cases/11,287 controls), revealed that there was no evidence for a significant association under the dominant model (OR = 0.99 [0.92-1.07], P = .82). However, there was a borderline association under the recessive model (OR = 1.29 [0.99-1.67], P = .06) that became significant when considering men only (OR = 1.73 [1.20-2.48], P = .003). In conclusion, the PPARG Ala12Ala genotype might be associated with a higher CHD risk in men but further confirmation studies are needed.
authors.affiliation: Service d'Epidémiologie et de Santé Publique, Institut Pasteur de Lille, Lille; INSERM, U744, Lille; Université Nord de France, Lille; UDSL, 59019 Lille, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Dallongeville
authors.forename: Carlos
authors.initials: C
authors.lastname: Iribarren
authors.forename: Jean
authors.initials: J
authors.lastname: Ferrières
authors.forename: Liisa
authors.initials: L
authors.lastname: Lyon
authors.forename: Alun
authors.initials: A
authors.lastname: Evans
authors.forename: Alan S
authors.initials: AS
authors.lastname: Go
authors.forename: Dominique
authors.initials: D
authors.lastname: Arveiler
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Fortmann
authors.forename: Pierre
authors.initials: P
authors.lastname: Ducimetière
authors.forename: Mark A
authors.initials: MA
authors.lastname: Hlatky
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.forename: Audrey
authors.initials: A
authors.lastname: Southwick
authors.forename: Thomas
authors.initials: T
authors.lastname: Quertermous
authors.forename: Aline
authors.initials: A
authors.lastname: Meirhaeghe