title: A mathematical model of the indirect effects of rotavirus vaccination.
abstract: Rotavirus (RV) infections progressively confer natural immunity against subsequent infection. Similarly to natural infection, vaccination with a live attenuated vaccine potentially reduces RV transmission and induces herd protection. A mathematical transmission model was developed to project the impact of a vaccination programme on the incidence of RV infection and disease for five countries in the European Union. With vaccination coverage rates of 70%, 90% and 95% the model predicted that, in addition to the direct effect of vaccination, herd protection induced a reduction in RV-related gastroenteritis (GE) incidence of 25%, 22% and 20%, respectively, for RV-GE of any severity, and of 19%, 15%, and 13%, respectively, for moderate-to-severe RV-GE, 5 years after implementation of a vaccination programme.
authors.affiliation: GlaxoSmithKline Biologicals, Wavre 1300, Belgium. Thierry.van-effelterre@gskbio.com
authors.forename: T
authors.initials: T
authors.lastname: Van Effelterre
authors.forename: M
authors.initials: M
authors.lastname: Soriano-Gabarró
authors.forename: S
authors.initials: S
authors.lastname: Debrus
authors.forename: E
authors.initials: E
authors.lastname: Claire Newbern
authors.forename: J
authors.initials: J
authors.lastname: Gray
mesh_terms: D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology; D006801:Humans; D032521:Immunity, Herd; D032541:Mass Vaccination; D008954:Models, Biological; D015397:Program Evaluation; D012400:Rotavirus Infections / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D022243:Rotavirus Vaccines; D016896:Treatment Outcome
chemical_list: D022243:Rotavirus Vaccines