Reverse transcribing the code for chromosome stability.
The linearity of eukaryotic chromosomes presents challenges to cells, as the presence of DNA "ends" poses problems for the DNA replication machinery and the cell's damage response systems. This year's Nobel Prize in Physiology or Medicine recognized groundbreaking studies establishing the telomere field as a crucial area of biomedical research.
Artandi
Steven E
SE
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. sartandi@stanford.edu
Cooper
Julia Promisel
JP
D043171:Chromosomal Instability; D004261:DNA Replication; D005823:Genetics / Q000266:history*; D049673:History, 20th Century; D006801:Humans; D008938:Mitosis; D008957:Models, Genetic; D009613:Nobel Prize; D019098:Telomerase / Q000266:history* / Q000378:metabolism; D016615:Telomere / Q000502:physiology
D019098:Telomerase