title: UR-60427, a novel H4 receptor-inverse agonist that shows good efficacy in a rat asthma model.
authors.affiliation: Palau Pharma SA, Palau-solità i Plegamans, Barcelona, Spain. jalfon@palaupharma.com
authors.forename: J
authors.initials: J
authors.lastname: Alfón
authors.forename: N
authors.initials: N
authors.lastname: Ardanaz
authors.forename: B
authors.initials: B
authors.lastname: Gil-Torregrosa
authors.forename: A
authors.initials: A
authors.lastname: Fernández
authors.forename: D
authors.initials: D
authors.lastname: Balsa
authors.forename: E
authors.initials: E
authors.lastname: Carceller
authors.forename: Ll
authors.initials: L
authors.lastname: Gómez
authors.forename: M
authors.initials: M
authors.lastname: Merlos
authors.forename: J
authors.initials: J
authors.lastname: Cortijo
authors.forename: E
authors.initials: E
authors.lastname: Morcillo
authors.forename: X
authors.initials: X
authors.lastname: Bartrolí
mesh_terms: D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D001249:Asthma / Q000188:drug therapy*; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000503:physiopathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D016466:CHO Cells; D002452:Cell Count; D006224:Cricetinae; D003412:Cricetulus; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000494:pharmacology; D017442:Histamine Agonists / Q000494:pharmacology*; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000819:agonists*; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4; D012701:Serotonin / Q000494:pharmacology
chemical_list: D018927:Anti-Asthmatic Agents; D017442:Histamine Agonists; C498828:Hrh4 protein, rat; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4; D012701:Serotonin; D016244:Guanosine 5'-O-(3-Thiotriphosphate)