Comparative analysis of Micrococcus luteus isolates from blood cultures of patients with pulmonary hypertension receiving epoprostenol continuous infusion.
During the period 2002-2008, at the National Cardiovascular Center, Osaka, 28 Micrococcus luteus isolates and one Kocuria spp. isolate were obtained from blood cultures of pulmonary hypertension (PH) patients who were receiving continuous infusion therapy with epoprostenol. Pulsed-field gel electrophoresis patterns of the isolates were unrelated, suggesting that the infections had multiple origins. The preparation of epoprostenol solution by patients themselves was thought to be a risk factor.
Hirata
Yoshinori
Y
Department of Clinical Laboratory, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka, 565-8565, Japan.
Sata
Makoto
M
Makiuchi
Yuko
Y
Morikane
Keita
K
Wada
Akihito
A
Okabe
Nobuhiko
N
Tomoike
Hitonobu
H
D000959:Antihypertensive Agents / Q000008:administration & dosage; D002408:Catheters, Indwelling / Q000382:microbiology; D004340:Drug Contamination; D016521:Electrophoresis, Gel, Pulsed-Field; D011464:Epoprostenol / Q000008:administration & dosage*; D016908:Gram-Positive Bacterial Infections / Q000097:blood* / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood / Q000188:drug therapy / Q000382:microbiology*; D007262:Infusions, Intravenous; D016982:Micrococcus luteus / Q000235:genetics / Q000302:isolation & purification*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage
D000959:Antihypertensive Agents; D010975:Platelet Aggregation Inhibitors; D011464:Epoprostenol