Viruses and their potential in bioimaging and biosensing applications.
Successful development of ultrasensitive constructs for bioimaging and biosensing is a challenging task. Recently, viruses have drawn increasing attention due to their exquisite three-dimensional structures and unique properties, including multivalency, orthogonal reactivities, and responsiveness to genetic modifications. With such well-characterized structures, functional units, such as imaging and binding motifs, can be engineered on the surface of viruses in a programmable, polyvalent manner, which leads to novel nanosized sensing/imaging systems with enhanced signaling and targeting performance. This review highlights some recent progress in the applications of viruses in bioimaging and biosensing.
Li
Kai
K
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, PR China.
Nguyen
Huong Giang
HG
Lu
Xiaobing
X
Wang
Qian
Q
D055910:Antibodies, Immobilized / Q000276:immunology / Q000378:metabolism; D001435:Bacteriophages / Q000235:genetics / Q000378:metabolism; D015374:Biosensing Techniques / Q000379:methods*; D036022:Capsid Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D005456:Fluorescent Dyes / Q000737:chemistry; D005818:Genetic Engineering; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry; D014780:Viruses / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
D055910:Antibodies, Immobilized; D036022:Capsid Proteins; D005456:Fluorescent Dyes