[Effect of sutent and celecoxib on the properties of endothelial cells in vitro].
We studied the anti-angiogenic properties of sutent (SU11248) and celecoxib in human endothelial cell line EA. hy 926 in vitro. Sutent 0.05-0.5 microg/ml suppressed their proliferation and migration depending on dose while celecoxib did the same at 5.0 microg/ml. We were the first to demonstrate that endothelial cell incubation was followed by increase in 5'-nucleotidase activity in the presence of sutent while celecoxib did not produce such effect. It may be suggested that elevated 5'-nucleotidase concentration at the membranes of endothelial cells might in turn contribute to the pool of extracellular adenosine to stimulate antiinflammatory effect. Our data also contribute to the knowledge about the anti-angiogenic properties of sutent and celecoxib.
Liamina
I V
IV
Starikova
E A
EA
Kuznetsova
S A
SA
Kiseleva
E P
EP
Freĭdlin
I S
IS
D015720:5'-Nucleotidase / Q000378:metabolism*; D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000068579:Celecoxib; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D042783:Endothelial Cells / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D011758:Pyrroles / Q000494:pharmacology*; D013449:Sulfonamides / Q000494:pharmacology*; D000077210:Sunitinib
D020533:Angiogenesis Inhibitors; D000893:Anti-Inflammatory Agents; D052246:Cyclooxygenase 2 Inhibitors; D007211:Indoles; D011720:Pyrazoles; D011758:Pyrroles; D013449:Sulfonamides; D015720:5'-Nucleotidase; D000068579:Celecoxib; D000077210:Sunitinib