title: Synthesis of 4'-ester analogs of resveratrol and their evaluation in malignant melanoma and pancreatic cell lines.
abstract: 4'-Ester analogs of the disease preventative agent resveratrol were synthesized and evaluated for their potential as anti-melanoma and pancreatic cancer agents. A decarbonylative Heck coupling was used to assemble the protected stilbene core structure. The 4'-acetate and the palmitoate analogs demonstrated selective activity with DM443 and DM738 cells over normal NHDF cells.
authors.affiliation: Department of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wong
authors.forename: Gregory
authors.initials: G
authors.lastname: Osmond
authors.forename: Kenneth I
authors.initials: KI
authors.lastname: Brewer
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Tyler
authors.forename: Merritt B
authors.initials: MB
authors.lastname: Andrus
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000627:therapeutic use; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D004952:Esters; D018922:HL-60 Cells; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000077185:Resveratrol; D013267:Stilbenes / Q000138:chemical synthesis* / Q000378:metabolism / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004952:Esters; D013267:Stilbenes; D000077185:Resveratrol