title: Ototoxic drugs: difference in sensitivity between mice and guinea pigs.
abstract: The development of experimental animal models has played an invaluable role in understanding the mechanisms of neurosensory deafness and in devising effective treatments. The purpose of this study was to develop an adult mouse model of ototoxic drug-induced hearing loss and to compare the ototoxicity in the adult mouse to that in the well-described guinea pig model. Mice are a powerful model organism, especially due to the large availability of antibodies, probes and genetic mutants. In this study, mice (n=114) and guinea pigs (n=35) underwent systemic treatment with either kanamycin or cisplatin. Auditory brainstem responses showed a significant threshold shift in guinea pigs 2 weeks after the beginning of the ototoxic treatment, while there was no significant hearing impairment recorded in mice. Hair cells and neuronal loss were correlated with hearing function in both guinea pigs and mice. These results indicate that the mouse is not a good model for ototoxicity, which should be taken into consideration in all further investigations concerning ototoxicity-induced hearing loss.
authors.affiliation: Department of Otolaryngology, University Hospital of Liège, Liège, Belgium. alpoirrier@student.ulg.ac.be
authors.forename: A L
authors.initials: AL
authors.lastname: Poirrier
authors.forename: P
authors.initials: P
authors.lastname: Van den Ackerveken
authors.forename: T S
authors.initials: TS
authors.lastname: Kim
authors.forename: R
authors.initials: R
authors.lastname: Vandenbosch
authors.forename: L
authors.initials: L
authors.lastname: Nguyen
authors.forename: P P
authors.initials: PP
authors.lastname: Lefebvre
authors.forename: B
authors.initials: B
authors.lastname: Malgrange
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D000970:Antineoplastic Agents / Q000633:toxicity*; D002945:Cisplatin / Q000633:toxicity*; D003638:Deafness / Q000139:chemically induced* / Q000473:pathology; D064420:Drug-Related Side Effects and Adverse Reactions; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D006309:Hearing / Q000187:drug effects; D007612:Kanamycin / Q000633:toxicity*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009474:Neurons / Q000473:pathology; D009925:Organ of Corti / Q000473:pathology; D013045:Species Specificity; D013136:Spiral Ganglion / Q000187:drug effects / Q000473:pathology; D014048:Tolonium Chloride
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D014048:Tolonium Chloride; D007612:Kanamycin; D002945:Cisplatin