Allogeneic stem cell transplantation in patients with β-thalassemia: King Faisal specialist hospital and research centre experience.
From January 1998-July 2006, 62 stem cell transplantation (SCT) were performed on 60 patients with beta-thalassemia from HLA-related match donors. The overall survival (OS) and event free survival (EFS) for all patients were 94 and 77%. The outcome of allogeneic SCT in our experience is satisfactory with OS 92% and EFS 77%. Transplantation at a young age and when the disease is mild offers the best outcome. More advanced disease is associated with higher rate of rejection and severe graft versus host disease.
Al-Jefri
A
A
King Faisal Specialist Hospital and Research Centre (KFSH&RC), Riyadh, Saudi Arabia. ajefri@kfshrc.edu.sa
Ayas
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A
Al Musa
A
A
Al Mahr
M
M
Al Saleh
M
M
Rifai
S
S
Sabbah
R
R
Al Seraihy
A
A
Al Ahmari
A
A
Khairy
E
E
Al Hassan
I
I
El Solh
H
H
D006084:Graft Rejection / Q000276:immunology; D006086:Graft vs Host Disease / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D006782:Hospitals, Special / Q000145:classification*; D006801:Humans; D012189:Retrospective Studies; D012307:Risk Factors; D012529:Saudi Arabia; D016019:Survival Analysis; D016896:Treatment Outcome; D017086:beta-Thalassemia / Q000150:complications / Q000401:mortality / Q000628:therapy*