title: [Relationship between epithelial-mesenchymal transition and basal cell-like phenotype in breast cancer].
abstract: OBJECTIVE
  To evaluate the relationship between epithelial-mesenchymal transition and basal cell-like phenotype breast cancer (BLBC).
  
  
  METHODS
  Three hundred and eighty two cases of breast cancers including basal cell-like, luminal A, luminal B and Her-2 subtypes were collected from 458 cases of invasive breast cancers based on their immunophenotypes. They were then stained immunohistochemically with FOXC-2, vimentin, Syndecan-1 and E-cadherin. The relationship of these markers with the basal cell-like phenotype of breast cancer was studied.
  
  
  RESULTS
  Of the 41 BLBC cases, FOXC-2, vimentin and Syndecan-1 were positive in 14 cases (34.1%), 18 cases (43.9%) and 36 cases (87.7%) respectively; E-cadherin expression was reduced in 26 cases (63.4%). The positive rates of FOXC-2 and vimentin were higher in BLBC than in other subtypes of breast cancer (P < 0.01). The expression of E-cadherin was the lowest among the 4 subtypes of breast cancers (P < 0.01). Syndecan-1 was positive in the stromal cells adjacent to cancer cells in 17 cases (41.5%) BLBC and the expression was higher than that in other subtypes (P = 0.007). There existed a correlation between FOXC-2 and vimentin expression in BLBC (r = 0.607, P < 0.01). The rates of positive lymph nodes in FOXC-2 and vimentin positive BLBC cases were 71.4% and 66.7% respectively, and both were higher than those of FOXC-2 and vimentin negative BLBC cases (P = 0.002 and P = 0.001).
  
  
  CONCLUSIONS
  Epithelial-mesenchymal transition is probably related to the basal cell-like phenotype of breast cancers, and this may be one of the reasons accounting for the different biological behavior of BLBC from other subtypes of breast cancer.
authors.affiliation: Department of Pathology, First Affiliated Hospital of Jiaxing College, Jiaxing 314000, China. wanxinwu@hotmail.com
authors.forename: Wan-xin
authors.initials: WX
authors.lastname: Wu
authors.forename: Yan-ping
authors.initials: YP
authors.lastname: Zhang
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Wen
authors.forename: Ning
authors.initials: N
authors.lastname: Lu
authors.forename: Zheng-ying
authors.initials: ZY
authors.lastname: Tang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Hong-jie
authors.initials: HJ
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000145:classification / Q000378:metabolism* / Q000473:pathology*; D015820:Cadherins / Q000378:metabolism; D018270:Carcinoma, Ductal, Breast / Q000145:classification / Q000378:metabolism* / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000145:classification / Q000378:metabolism / Q000473:pathology; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D016130:Immunophenotyping; D008207:Lymphatic Metastasis; D008875:Middle Aged; D010641:Phenotype; D053668:Syndecan-1 / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D051858:Forkhead Transcription Factors; D053668:Syndecan-1; D014746:Vimentin; C082078:mesenchyme fork head 1 protein