Antitubercular potential of some semisynthetic analogues of phytol.
Phytol, a diterpene alcohol was modified to several semisynthetic analogues. Some of the modifications were done logically to enhance lipophilicity of the molecule. Analogues 14, 16 and 18 exhibited antitubercular activity (MIC 15.6-50microg/mL) better than phytol (100microg/mL). The most potent analogue 18 was evaluated for in vivo toxicity in Swiss albino mice and was well tolerated by the experimental animals up to 300mg/kg body weight as a single oral acute dose.
Saikia
Dharmendra
D
Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Kukrail Picnic Spot Road, PO CIMAP, Lucknow 226 015, UP, India.
Parihar
Swati
S
Chanda
D
D
Ojha
S
S
Kumar
J K
JK
Chanotiya
C S
CS
Shanker
K
K
Negi
Arvind S
AS
D000818:Animals; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D051379:Mice; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D010836:Phytol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity
D000995:Antitubercular Agents; D010091:Oximes; D010836:Phytol