title: Public involvement in pharmacogenomics research: a national survey on patients' attitudes towards pharmacogenomics research and the willingness to donate DNA samples to a DNA bank in Japan.
abstract: To assess the attitude of Japanese patients towards pharmacogenomics research and a DNA bank for identifying genomic markers associated with adverse drug reactions (ADRs) and their willingness to donate DNA samples, we conducted a survey of 550 male and female patients. The majority of the respondents showed a positive attitude towards pharmacogenomics research (87.6%) and a DNA bank (75.1%). The willingness to donate DNA samples when experiencing severe ADRs (55.8%) was higher than when taking medications (40.4%). Positive attitudes towards a DNA bank and organ donation were significantly associated with an increased willingness to donate. Though the level of positive attitude in the patient population was higher than that in the general public in our former study (81.0 and 70.4%, respectively), the level of the willingness of patients to donate was 40.4% when taking medications and 55.8% when experiencing severe ADRs which was lower than that of the general public in our former study (45.3 and 61.7%). The results suggested that the level of true willingness in the patient population was lower than that of the general public considering the fictitious situation presented to the public (to suppose that they were patients receiving medication). It is important to assess the willingness of patients who are true potential donors, not the general public.
authors.affiliation: Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8675, Japan. erikokob@p.chiba-u.ac.jp
authors.forename: Eriko
authors.initials: E
authors.lastname: Kobayashi
authors.forename: Tomoya
authors.initials: T
authors.lastname: Sakurada
authors.forename: Shiro
authors.initials: S
authors.lastname: Ueda
authors.forename: Nobunori
authors.initials: N
authors.lastname: Satoh
mesh_terms: D000328:Adult; D000368:Aged; D001294:Attitude to Health; D004247:DNA / Q000235:genetics; D030561:Databases, Nucleic Acid; D064420:Drug-Related Side Effects and Adverse Reactions / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics / Q000706:statistics & numerical data; D011639:Public Opinion; D011795:Surveys and Questionnaires; D014015:Tissue Banks / Q000706:statistics & numerical data; D014019:Tissue Donors / Q000706:statistics & numerical data; D009927:Tissue and Organ Procurement / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D005819:Genetic Markers; D004247:DNA