title: Local activation time derived from stored EGM is associated with failure of antitachycardia pacing in patients with implantable defibrillator.
abstract: BACKGROUND
  Antitachycardia pacing (ATP) is an effective treatment of ventricular tachycardia (VT). However, persistent failure of ATP in some patients is well recognized.
  
  
  METHODS
  A method of deriving the local activation time from stored intracardiac electrograms in implantable cardioverter defibrillators is described. Using a case-control design, the local activation times were compared between patients with persistent unsuccessful ATP with comparable controls with successful ATP.
  
  
  RESULTS
  The local activation times during VT in patients with failed ATP were longer at 120-180 ms compared with corresponding control patients with successful ATP (60-80 ms). The local activation time expressed as a proportion of VT cycle length in patients with failed ATP compared with patients with successful ATP were 0.40 +/- 0.08 versus 0.19 +/- 0.08 (P = 0.012).
  
  
  CONCLUSIONS
  A novel method of deriving local activation time is described, and delayed local activation time may explain failure of ATP in terminating VT in some patients.
authors.affiliation: University Hospital Birmingham, Edgbaston, Birmingham, United Kingdom. hsern@doctors.net.uk
authors.forename: Hoong Sern
authors.initials: HS
authors.lastname: Lim
authors.forename: Mauro
authors.initials: M
authors.lastname: Lencioni
authors.forename: Howard
authors.initials: H
authors.lastname: Marshall
mesh_terms: D000368:Aged; D002304:Cardiac Pacing, Artificial; D016022:Case-Control Studies; D017147:Defibrillators, Implantable; D004562:Electrocardiography; D004868:Equipment Failure; D005260:Female; D006801:Humans; D008297:Male; D017180:Tachycardia, Ventricular / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome