title: Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.
abstract: In order to evaluate the population impact of putative causal genetic variants over the life course of disease, we extended the static estimation of population-attributable risk fraction and developed a novel tool to evaluate how the population impact changes over time using the Framingham Heart Study Offspring Cohort data provided to the Genetic Analysis Workshop 16, Problem 2. A set of population-attributable risk fractions based on survival functions were estimated under the proportional hazards models. The development of this novel measure of population impact creates a more comprehensive estimate of population impact over the life course of disease, which may help us to better understand genetic susceptibility at the population level.
authors.affiliation: Department of Epidemiology, University of North Carolina, 2101 McGavran-Greenberg Hall, Chapel Hill, North Carolina 27599, USA. yuyan.unc@gmail.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yan
authors.forename: Yijuan
authors.initials: Y
authors.lastname: Hu
authors.forename: Kari E
authors.initials: KE
authors.lastname: North
authors.forename: Nora
authors.initials: N
authors.lastname: Franceschini
authors.forename: Danyu
authors.initials: D
authors.lastname: Lin