title: Synthesis and biological studies of some gold(I) complexes containing functionalised alkynes.
abstract: The propargyl ethers 7-chloro-(4-propargyloxy)quinoline, 1-propargyloxynaphthalene and 2-propargyloxybenzophenone react with [AuCl(PPh(3))] in the presence of KOH to give the gold(I) alkynyl complexes [Au(C[triple bond]COCH(2)Ar)(PPh(3))] in good yields. The compounds were fully characterised by spectroscopic methods and were subsequently examined for their biological activity against four tumour cell lines as well as their activity against Plasmodium falciparum, the parasite responsible for malaria. The compounds show antiproliferative effects in human cancer cells with IC(50) values ranging from 0.4-12 microM.
authors.affiliation: Fachbereich C, Anorganische Chemie Bergische Universität Wuppertal, Gaussstr. 20, D-42929, Wuppertal, Germany.
authors.forename: Esther
authors.initials: E
authors.lastname: Schuh
authors.forename: Seied M
authors.initials: SM
authors.lastname: Valiahdi
authors.forename: Michael A
authors.initials: MA
authors.lastname: Jakupec
authors.forename: Bernhard K
authors.initials: BK
authors.lastname: Keppler
authors.forename: Peter
authors.initials: P
authors.lastname: Chiba
authors.forename: Fabian
authors.initials: F
authors.lastname: Mohr
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D001577:Benzophenones / Q000737:chemistry; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D004354:Drug Screening Assays, Antitumor; D006046:Gold / Q000737:chemistry*; D006801:Humans; D009281:Naphthalenes / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D011804:Quinolines / Q000737:chemistry
chemical_list: D000480:Alkynes; D000962:Antimalarials; D000970:Antineoplastic Agents; D001577:Benzophenones; D056831:Coordination Complexes; D009281:Naphthalenes; D011804:Quinolines; C031721:naphthalene; C047723:benzophenone; D006046:Gold; C037219:quinoline