Cytotoxic 3,4-seco-cycloartane triterpenes from the exudate of Gardenia tubifera.
Four new 3,4-seco-cycloartanes, gardenoins A-D (1-4), together with the known compound secaubryenol (5), were isolated from the exudate of Gardenia tubifera. The structures of 1-4 were elucidated on the basis of spectroscopic analysis. The cytotoxic activity of compounds 1-4 was evaluated against five human tumor cell lines.
Nuanyai
Thanesuan
T
Research Centre of Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Chokpaiboon
Sipichar
S
Vilaivan
Tirayut
T
Pudhom
Khanitha
K
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D032062:Gardenia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013785:Thailand; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C516505:secaubryenol