Diarylprolinol silyl ether salts as new, efficient, water-soluble, and recyclable organocatalysts for the asymmetric Michael addition on water.
A novel strategy for the catalytic asymmetric Michael addition of aldehydes to nitroolefins on water has been developed and provided the Michael adducts in excellent diastereo- and enantioselectivities. A notable feature of these organocatalysts is that they can be recycled for more than six times without a significant loss of catalytic activity and stereochemical control. In addition, the synthetic procedure presented is simple, practical, and environmentally benign.
Zheng
Zilong
Z
Department of Chemistry, Texas A&M University-Commerce, Commerce, Texas 75429-3011, USA.
Perkins
Benjamin L
BL
Ni
Bukuo
B