Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group: applications in ratiometric oxygen sensing in vitro and in regioselective cell killing.
A terbium complex has been designed that may be used to sensitise formation of singlet oxygen (phi(em) 12%), allowing the creation of a ratiometric sensory system for pO(2) (versus the insensitive Eu analogue) and the definition of a reactive probe that can be used to cause local damage to cells loaded with the complex and exposed to laser excitation.
Law
Ga-Lai
GL
Department of Chemistry, Durham University, South Road, Durham, UK DH1 3LE.
Pal
Robert
R
Palsson
Lars O
LO
Parker
David
D
Wong
Ka-Leung
KL
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001372:Aza Compounds / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D009284:Naphthols / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013725:Terbium / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry* / Q000494:pharmacology
D001372:Aza Compounds; D009284:Naphthols; D044004:Xanthones; D013725:Terbium; C009689:xanthone; D010100:Oxygen