title: Multidrug-resistant Enterococcus faecium meningitis in a toddler: characterization of the organism and successful treatment with intraventricular daptomycin and intravenous tigecycline.
abstract: A case of enterococcal meningitis in a toddler is presented. The organism was highly resistant to all drugs previously used for pediatric Gram-positive meningitis. She was successfully treated with intraventricular and intravenous daptomycin and intravenous tigecycline. The organism was characterized as a member of CC17, a notorious emerging nosocomial clone of Enterococcus faecium.
authors.affiliation: Department of Pediatrics, Seattle Children's Hospital, Seattle WA 98105, USA. heather.jaspan@sbri.org
authors.forename: Heather B
authors.initials: HB
authors.lastname: Jaspan
authors.forename: Adam W
authors.initials: AW
authors.lastname: Brothers
authors.forename: Angela J P
authors.initials: AJ
authors.lastname: Campbell
authors.forename: John K
authors.initials: JK
authors.lastname: McGuire
authors.forename: Samuel R
authors.initials: SR
authors.lastname: Browd
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Manley
authors.forename: Daniel
authors.initials: D
authors.lastname: Pak
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Weissman
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D017576:Daptomycin / Q000008:administration & dosage / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D016984:Enterococcus faecium / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D016920:Meningitis, Bacterial / Q000188:drug therapy / Q000382:microbiology; D008911:Minocycline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000078304:Tigecycline; D016896:Treatment Outcome; D020713:Vancomycin Resistance
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline; D017576:Daptomycin