Rhythmoinotropic myocardial reactions in rats with postinfarction cardiosclerosis against the background of streptozotocin-induced diabetes.
We studied rhythmoinotropic reactions of the myocardium in rats with postinfarction cardiosclerosis and in rats with postinfarction cardiosclerosis against the background of streptozotocin-induced diabetes. Inotropic myocardial response in rats with postinfarction cardiosclerosis was significantly inhibited after rest periods, while in streptozotocin diabetic rats the rhythmoinotropic myocardial reaction was comparable with the reaction of intact myocardium. The combination of postinfarction cardiosclerosis and diabetes paradoxically contributed to preservation of contractile function of the myocardium in rats.
Kondtratieva
D S
DS
Institute of Cardiology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Russia. dina@cardio.tsu.ru
Afanasiev
S A
SA
Rebrova
T Yu
TY
Tsapko
L P
LP
Karpov
R S
RS
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000378:metabolism; D008297:Male; D009203:Myocardial Infarction / Q000150:complications*; D009206:Myocardium / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D012519:Sarcoplasmic Reticulum / Q000378:metabolism