title: Proliferation and survival of rat C6 glioma culture in the presence of implants coated with modified carbon-based films.
abstract: The survival of rat C6 glioma decreased in the presence of implants from VT-16 titanium alloy. Diamond-like carbon coating of VT-16 alloy slightly increased cell death on day 5 of the experiment (39.9+/-2.1%). The percentage of dead C6 glioma cells inside titanium rings with diamond-like carbon coating, incorporating up to 3.5 atom.% Ag nanoparticles, was 53.7+/-4.3% on day 5 of culturing, while after doping to 6.7 atom.% Ag cell death reached 66.7+/-3.2% (p<0.05). The maximum toxic effect towards C6 glioma was detected in the specimens coated with diamond-like film with silver nanoparticles.
authors.affiliation: Department of Physiology and General Pathology, Institute of Physiology, National Academy of Sciences of Belarus, Minsk, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Pozdniak
authors.forename: A N
authors.initials: AN
authors.lastname: Chernov
authors.forename: N M
authors.initials: NM
authors.lastname: Chekan
authors.forename: N M
authors.initials: NM
authors.lastname: Beliauski
authors.forename: V V
authors.initials: VV
authors.lastname: Akulich
authors.forename: G G
authors.initials: GG
authors.lastname: Poljanskaya
authors.forename: A I
authors.initials: AI
authors.lastname: Gordienko
authors.forename: V A
authors.initials: VA
authors.lastname: Kulchitsky
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D002244:Carbon / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005910:Glioma / Q000473:pathology*; D053768:Metal Nanoparticles / Q000633:toxicity; D051381:Rats; D012834:Silver / Q000737:chemistry; D014025:Titanium / Q000633:toxicity*
chemical_list: D001672:Biocompatible Materials; D012834:Silver; D002244:Carbon; D014025:Titanium