title: Clinical differences between early-onset HELLP syndrome and early-onset preeclampsia during pregnancy and at least 6 months postpartum.
abstract: OBJECTIVE
  We sought to evaluate whether clinical and laboratory variables differ between former patients who had HELLP syndrome and former patients who had preeclampsia (PE) without HELLP.
  
  
  METHODS
  We compared early-onset HELLP (n = 75) with early-onset PE (n = 40) with respect to clinical features during the hypertensive complication and to metabolic, hemodynamic, and hemostatic variables determined at least 6 months postpartum.
  
  
  RESULTS
  HELLP differed from PE by a borderline higher frequency of eclampsia (13% vs 3%) during the complication, and by a lower prevalence of hypertension (19% vs 33%), proteinuria (2% vs 23%), thrombophilia (6% vs 27%), obesity (9% vs 33%), hypertriglyceridemia (1% vs 15%), hyperglycemia (0% vs 11%), and elevated levels of fasting homocysteine (6% vs 21%) at least 6 months postpartum.
  
  
  CONCLUSIONS
  Women with HELLP had fewer signs of abnormalities consistent with the metabolic syndrome and a 4-fold lower prevalence of thrombophilia as compared with PE women without HELLP.
authors.affiliation: Department of Obstetrics and Gynecology, Maastricht University Medical Center, Maastricht, The Netherlands. simone.sep@og.unimaas.nl
authors.forename: Simone
authors.initials: S
authors.lastname: Sep
authors.forename: Jef
authors.initials: J
authors.lastname: Verbeek
authors.forename: Gerardus
authors.initials: G
authors.lastname: Koek
authors.forename: Luc
authors.initials: L
authors.lastname: Smits
authors.forename: Marc
authors.initials: M
authors.lastname: Spaanderman
authors.forename: Louis
authors.initials: L
authors.lastname: Peeters
mesh_terms: D000328:Adult; D004461:Eclampsia / Q000453:epidemiology; D005165:Factor V / Q000235:genetics; D005260:Female; D017359:HELLP Syndrome / Q000453:epidemiology*; D006339:Heart Rate; D006710:Homocysteine / Q000097:blood; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology; D006943:Hyperglycemia / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D015228:Hypertriglyceridemia / Q000453:epidemiology; D009154:Mutation; D009765:Obesity / Q000453:epidemiology; D049590:Postpartum Period; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D011507:Proteinuria / Q000453:epidemiology; D011516:Prothrombin / Q000235:genetics; D019851:Thrombophilia / Q000453:epidemiology
chemical_list: C095381:factor V Leiden; D006710:Homocysteine; D005165:Factor V; D011516:Prothrombin