title: Inhibition of Vascular Endothelial Growth Factor Receptor-1/Wnt/{beta}-catenin Crosstalk Leads to Tumor Cell Death.
abstract: Two genes are considered synthetic lethal if mutation of either alone allows cell viability, whereas simultaneous mutation leads to cell death. A synthetic lethal screen unveiled the dependency of Wnt/beta-catenin-addicted colorectal cancer cells on vascular endothelial growth factor receptor-1 kinase activity and suggested a novel therapeutic approach for this malignancy. (Clin Cancer Res 2009;15(24):7453-5).
authors.affiliation: Authors' Affiliations: Angiogenesis Research Laboratory, Department of Restorative Sciences, School of Dentistry; Department of Biomedical Engineering, College of Engineering; Department of Otolaryngology, School of Medicine, University of Michigan, Ann Arbor, Michigan; and Departments of Surgical Oncology and Cancer Biology, Maryland Anderson Cancer Center, University of Texas, Houston, Texas.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Zeitlin
authors.forename: Lee M
authors.initials: LM
authors.lastname: Ellis
authors.forename: Jacques E
authors.initials: JE
authors.lastname: Nör