Penicillin-binding proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes.
While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem.
Van de Velde
Sébastien
S
Unité de pharmacologie cellulaire et moléculaire, Université catholique de Louvain, Bruxelles, Belgium. sebastien.vandevelde@uclouvain.be
Carryn
Stéphane
S
Van Bambeke
Françoise
F
Hill
Colin
C
Tulkens
Paul M
PM
Sleator
Roy D
RD