Taking off the SOCS: cytokine signaling spurs regeneration.
Strategies to improve function after CNS injuries must contend with the failure of axons to regrow after transection in adult mammals. In this issue of Neuron, Smith et al. provide an important advance by demonstrating that SOCS3 acts as a key negative regulator of adult optic nerve regeneration.
Newbern
Jason M
JM
Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. jason_newbern@med.unc.edu
Shoemaker
Sarah E
SE
Snider
William D
WD
D000818:Animals; D006801:Humans; D051379:Mice; D009416:Nerve Regeneration / Q000502:physiology*; D009901:Optic Nerve Diseases / Q000235:genetics / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology*; D050826:Suppressor of Cytokine Signaling Proteins / Q000009:adverse effects* / Q000235:genetics / Q000378:metabolism
D050826:Suppressor of Cytokine Signaling Proteins