title: Cronkhite-Canada syndrome associated with myelodysplastic syndrome.
abstract: We report a case of Cronkhite-Canada syndrome (CCS) associated with myelodysplastic syndrome (MDS). A 54-year-old woman, diagnosed as MDS the prior year after evaluation of anemia, visited our hospital with the chief complaint of epigastric discomfort. She also had dysgeusia, alopecia, atrophic nail change, and pigmentation of the palm, all of which began several months ago. Blood tests revealed severe hypoalbuminemia. Colonoscopy (CS) showed numerous, dense, red polyps throughout the colon and rectum. Biopsy specimens showed stromal edema, infiltration of lymphocytes, and cystic dilatation of the crypt. Her clinical manifestations and histology were consistent with CCS. We prescribed corticosteroids, which dramatically improved her physical findings, laboratory data, and endoscopic findings. This is the first report of CCS in a patient with MDS.
authors.affiliation: Department of Internal Medicine II, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan. enterotube@hotmail.com
authors.forename: Rei
authors.initials: R
authors.lastname: Suzuki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Irisawa
authors.forename: Takuto
authors.initials: T
authors.lastname: Hikichi
authors.forename: Yuta
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kumakawa
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Ohira
mesh_terms: D000505:Alopecia / Q000209:etiology; D003113:Colonoscopy; D005260:Female; D006801:Humans; D044483:Intestinal Polyposis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications*; D009260:Nail Diseases / Q000209:etiology / Q000473:pathology; D012880:Skin Pigmentation