title: Mildly abnormal general movement quality in infants is associated with higher Mead acid and lower arachidonic acid and shows a U-shaped relation with the DHA/AA ratio.
abstract: We showed that docosahexaenoic acid (DHA) supplementation during pregnancy and lactation was associated with more mildly abnormal (MA) general movements (GMs) in the infants. Since this finding was unexpected and inter-individual DHA intakes are highly variable, we explored the relationship between GM quality and erythrocyte DHA, arachidonic acid (AA), DHA/AA and Mead acid in 57 infants of this trial. MA GMs were inversely related to AA, associated with Mead acid, and associated with DHA/AA in a U-shaped manner. These relationships may indicate dependence of newborn AA status on synthesis from linoleic acid. This becomes restricted during the intrauterine period by abundant de novo synthesis of oleic and Mead acids from glucose, consistent with reduced insulin sensitivity during the third trimester. The descending part of the U-shaped relation between MA GMs and DHA/AA probably indicates DHA shortage next to AA shortage. The ascending part may reflect a different developmental trajectory that is not necessarily unfavorable.
authors.affiliation: Laboratory Medicine University Medical Center Groningen, 9700 RB Groningen, The Netherlands. saskiavangoor@yahoo.com
authors.forename: S A
authors.initials: SA
authors.lastname: van Goor
authors.forename: A
authors.initials: A
authors.lastname: Schaafsma
authors.forename: J J H M
authors.initials: JJ
authors.lastname: Erwich
authors.forename: D A J
authors.initials: DA
authors.lastname: Dijck-Brouwer
authors.forename: F A J
authors.initials: FA
authors.lastname: Muskiet
mesh_terms: D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives* / Q000097:blood; D000328:Adult; D000465:Algorithms; D001095:Arachidonic Acids / Q000008:administration & dosage / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001942:Breast Feeding; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000097:blood*; D004912:Erythrocytes / Q000737:chemistry*; D005228:Fatty Acids, Essential / Q000172:deficiency; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009043:Motor Activity; D009460:Neurologic Examination; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013223:Statistics as Topic
chemical_list: D001095:Arachidonic Acids; D015415:Biomarkers; D005228:Fatty Acids, Essential; D004281:Docosahexaenoic Acids; D015126:8,11,14-Eicosatrienoic Acid; C010944:mead acid