title: Contrasting identity-by-descent estimators, association studies, and linkage analyses using the Framingham Heart Study data.
abstract: We explored the utility of population- and pedigree-based analyses using the Framingham Heart Study genome-wide 50 k single-nucleotide polymorphism marker data provided for Genetic Analysis Workshop 16. Our aims were: 1) to compare identity-by-descent sharing estimates from variable amounts of data; 2) to apply each of these estimates to a case-control association study designed to control for relatedness among samples; and 3) to contrast these results to those obtained using model-based and model-free linkage analysis methods.
authors.affiliation: Division of Medical Genetics, Department of Medicine, University of Washington, Health Sciences Building, K-253, Box 357720, Seattle, Washington 98195 USA. em27@u.washington.edu.
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Marchani
authors.forename: Yanming
authors.initials: Y
authors.lastname: Di
authors.forename: Yoonha
authors.initials: Y
authors.lastname: Choi
authors.forename: Charles
authors.initials: C
authors.lastname: Cheung
authors.forename: Ming
authors.initials: M
authors.lastname: Su
authors.forename: Frederick
authors.initials: F
authors.lastname: Boehm
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Thompson
authors.forename: Ellen M
authors.initials: EM
authors.lastname: Wijsman