title: [Side effects of proliferation signal inhibitors and their management].
abstract: Proliferation signal inhibitors (PSI) could help to lower the calcineurine inhibitors level to minimize their toxicity and improve long-term graft survival. Side effects of this drugs are specific and must been known. Hyperlipidemia and cutaneous side-effects are the most frequent, angioedema and interstital pneumonitis the most serious. In majority of cases, early and adapted management could limit the impact of these side effects.
authors.affiliation: Service de Chirurgie cardiaque, Les Hôpitaux Universitaires de Strasbourg, 1, place de l'Hôpital, 67000 Strasbourg, France. Eric.Epailly@chru-strasbourg.fr
authors.forename: E
authors.initials: E
authors.lastname: Epailly
authors.forename: R
authors.initials: R
authors.lastname: Lorho
mesh_terms: D000799:Angioedema / Q000139:chemically induced / Q000517:prevention & control; D065095:Calcineurin Inhibitors; D002921:Cicatrix / Q000517:prevention & control; D016572:Cyclosporine / Q000009:adverse effects; D006084:Graft Rejection / Q000517:prevention & control*; D006085:Graft Survival; D006402:Hematologic Diseases / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced / Q000517:prevention & control; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors*; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control; D008210:Lymphocele / Q000139:chemically induced / Q000517:prevention & control; D011014:Pneumonia / Q000139:chemically induced / Q000517:prevention & control; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D020123:Sirolimus / Q000009:adverse effects / Q000627:therapeutic use; D012871:Skin Diseases / Q000139:chemically induced / Q000517:prevention & control; D058570:TOR Serine-Threonine Kinases
chemical_list: D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D047908:Intracellular Signaling Peptides and Proteins; D016572:Cyclosporine; C546842:MTOR protein, human; D017346:Protein Serine-Threonine Kinases; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus