title: Cognitive impairment in patients with fibromyalgia syndrome as assessed by the mini-mental state examination.
abstract: BACKGROUND
  This study evaluated the frequency of cognitive impairment in patients with Fibromyalgia syndrome (FMS) using the Mini Mental State Examination (MMSE).
  
  
  METHODS
  We analyzed baseline data from all 46 patients with FMS and 92 age- and sex-matched controls per diagnosis of neuropathic (NeP) or mixed pain (MP) selected from a larger prospective study.
  
  
  RESULTS
  FMS had a slight but statistically significant lower score in the adjusted MMSE score (26.9; 95% CI 26.7-27.1) than either NeP (27.3; 95% CI 27.2-27.4) or MP (27.3; 27.2-27.5). The percentage of patients with congnitive impairment (adjusted MMSE <or= 26) was numerically higher in FMS (15%; 95% CI 6.3-29) compared with NeP (5%; 95% CI 1.8-12.2) or MP (5%; 95% CI 1.8-12.2) and higher than in the same age stratum of the general population (0.05%).
  
  
  CONCLUSIONS
  Compared with the population reference value, patients with FMS showed high frequency of cognitive impairment.
authors.affiliation: Department of Rheumatology, Hospital Virgen de la Victoria, Málaga, Spain. 952382694@terra.es
authors.forename: Jose
authors.initials: J
authors.lastname: Rodríguez-Andreu
authors.forename: Rosario
authors.initials: R
authors.lastname: Ibáñez-Bosch
authors.forename: Amparo
authors.initials: A
authors.lastname: Portero-Vázquez
authors.forename: Xavier
authors.initials: X
authors.lastname: Masramon
authors.forename: Javier
authors.initials: J
authors.lastname: Rejas
authors.forename: Rafael
authors.initials: R
authors.lastname: Gálvez
mesh_terms: D017677:Age Distribution; D001007:Anxiety / Q000175:diagnosis / Q000453:epidemiology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology* / Q000523:psychology; D015331:Cohort Studies; D015897:Comorbidity; D003627:Data Interpretation, Statistical; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology; D004185:Disability Evaluation; D005260:Female; D005356:Fibromyalgia / Q000453:epidemiology* / Q000523:psychology; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010147:Pain Measurement; D017678:Sex Distribution