Autoimmune thyroid disease in children and adolescents with idiopathic pulmonary arterial hypertension.
BACKGROUND
Previous studies have reported a high prevalence of autoimmune thyroid disease (AITD) in adult patients with pulmonary arterial hypertension (PAH). The aim of this retrospective study was to determine the prevalence of AITD in children and adolescents with idiopathic PAH (IPAH).


RESULTS
The study group included 16 patients who had been diagnosed as having idiopathic PAH when they were younger than 15 years old; all were younger than 20 years of age. Thyroid function and antithyroid antibody levels were examined regularly at 6-12-month intervals and when there were clinical signs of thyroid dysfunction. In total, 7 patients (44%) had AITD; 2 patients developed Graves' disease, 2 developed silent thyroiditis, and 3 had antithyroid antibodies with euthyroidism. The duration after PAH onset and the prostacyclin (PGI(2)) treatment period were significantly longer in patients with AITD (7.6+/-2.1 and 7.4+/-2.3 years, respectively) than in patients without AITD (5.0+/-1.1 and 4.8+/-1.2 years, respectively; P<0.01 and P<0.05).


CONCLUSIONS
The prevalence of AITD is high in children and adolescents with IPAH, so evaluation of thyroid function is important to prevent deterioration of right heart failure.
Satoh
Mari
M
Department of Pediatrics, Toho University Omori Medical Center, Tokyo, Japan. satomari@med.toho-u.ac.jp
Aso
Keiko
K
Nakayama
Tomotaka
T
Naoi
Kazuyuki
K
Ikehara
Satoshi
S
Uchino
Yumiko
Y
Shimada
Hiromitsu
H
Takatsuki
Shinichi
S
Matsuura
Hiroyuki
H
Saji
Tsutomu
T
D000293:Adolescent; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D011464:Epoprostenol / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000453:epidemiology*; D006980:Hyperthyroidism / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D007564:Japan / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D013960:Thyroid Function Tests; D013997:Time Factors
D000959:Antihypertensive Agents; D001323:Autoantibodies; D011464:Epoprostenol