Should microchimerism turn into rejection prophylactics?
Non-self cells can circulate in the body of an individual after any sort of contact with an allogeneic source of cells, thus creating a situation of chimerism that can be transient or prolonged over time. This situation may appear after stem cell transplantation, pregnancy, transfusion or transplantation. Concerning transplantation, many hypotheses have been formulated regarding the existence, persistence and role of these circulating cells in the host. We will review the principal hypotheses that have been formulated for years since the first description of non-self circulating cells in mammals to the utilization of artificially induced chimerism protocols for the achievement of tolerance.
Pujal
Josep-Maria
JM
Translational Research Laboratory, Institut Català d'Oncologia, Hospital Duran i Reynals, Avda Gran Via s/n, Km 2.7, 08907 L'Hospitalet de Llobregat, Barcelona, Spain. jmpujal@idibell.org
D000818:Animals; D046528:Chimerism; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D008297:Male; D011247:Pregnancy; D033581:Stem Cell Transplantation; D023001:Transplantation Tolerance; D014184:Transplantation, Homologous