The role of SRC-3 in human breast cancer.
Members of the nuclear receptor superfamily are ligand-regulated transcription factors involved in the control of a broad range of normal physiological and disease processes. The estrogen receptor alpha (ERalpha) is a member of the steriod receptor family, which is part of the nuclear receptor superfamily. ERalpha it is important for many biological processes and plays a key role in the pathogenesis of breast cancer. Gene regulation by ERalpha requires the recruitment of a multitude of transcriptional co-regulators to the promoters of estrogen-responsive genes. There is evidence in support of the involvement of these co-regulators in breast cancer progression. We review the role of steroid receptor co-activator-3 (SRC-3), which is frequently amplified in breast cancer, and its role in breast cancer risk, outcome and response to endocrine therapy in patients with breast cancer.
Gojis
Ondrej
O
Department of Pathology, Third Faculty of Medicine, Charles University Prague, Prague 10, 10000, Czech Republic.
Rudraraju
Bharath
B
Gudi
Mihir
M
Hogben
Katy
K
Sousha
Sami
S
Coombes
R Charles
RC
Coombes
Charles R
CR
Cleator
Susan
S
Palmieri
Carlo
C
D001943:Breast Neoplasms / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D056921:Nuclear Receptor Coactivator 3 / Q000378:metabolism*
D047628:Estrogen Receptor alpha; C538866:NCOA3 protein, human; D056921:Nuclear Receptor Coactivator 3