WD repeat domain of Dictyostelium myosin heavy chain kinase C functions in both substrate targeting and cellular localization.
Myosin II disassembly in Dictyostelium discoideum is regulated by three structurally related myosin heavy chain kinases (myosin II heavy chain kinase A [MHCK-A], -B, and -C). We show that the WD repeat domain of MHCK-C is unique in that it mediates both substrate targeting and subcellular localization, revealing a target for regulation that is distinct from those of the other MHCKs.
Franklin
Atiya
A
Department of Biology, University of North Carolina at Greensboro, Greensboro, NC 27402, USA.
Hyatt
Linzi
L
Chowdhury
Alyssa
A
Steimle
Paul A
PA
D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000032:analysis* / Q000235:genetics / Q000378:metabolism; D004023:Dictyostelium / Q000201:enzymology* / Q000378:metabolism; D024462:Myosin Type II / Q000737:chemistry / Q000378:metabolism; D017434:Protein Structure, Tertiary; D015800:Protozoan Proteins / Q000032:analysis* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D015800:Protozoan Proteins; D017871:Calcium-Calmodulin-Dependent Protein Kinases; C033142:myosin-heavy-chain kinase; D024462:Myosin Type II