Factors associated with impaired urinary albumin excretion in hypertensive individuals: albuminuria and hypertension.
Albuminuria is well established as a cardiovascular and renal risk factor. This study aimed to analyze factors associated with this condition in 267 hypertensive individuals, stratified according to urinary albumin excretion (UAE) as: G1--130 individuals with normoalbuminuria (24-h UAE<20 μg/min); G2--113 with microalbuminuria (UAE between 20 and 200 μg/min); and G3--24 with macroalbuminuria (UAE≥200 μg/min). There were significant differences among the groups for blood pressure levels, left ventricular mass and index, estimated glomerular filtration rate, serum creatinine, renal dysfunction and diabetes mellitus (p<0.05). Macroalbuminuria was associated with renal dysfunction (OR=5.91; 95% CI: 2.44-14.31; p<0.001) and microalbuminuria with LVH (OR=2.21; 95% CI: 1.27-3.85; p=0.005). The association between UAE with blood pressure levels, diabetes and target-organ damage in hypertensive individuals suggests that adequate control of cardiovascular risk factors should be pursued to decrease morbidity associated with these conditions.
de Melo
Renan Oliveira Vaz
ROV
Hypertension Clinic, Department of Internal Medicine, State Medical School of São José do Rio Preto/SP (FAMERP), Brazil. Electronic address: renanovmelo@gmail.com.
Toledo
Juan Carlos Yugar
JCY
Hypertension Clinic, Department of Internal Medicine, State Medical School of São José do Rio Preto/SP (FAMERP), Brazil.
Souza
Dorotéia Rossi Silva
DRS
Molecular Biology Department, State Medical School of São José do Rio Preto/SP (FAMERP), Brazil.
Martin
José Fernando Vilela
JFV
Hypertension Clinic, Department of Internal Medicine, State Medical School of São José do Rio Preto/SP (FAMERP), Brazil.
D000368:Aged; D000419:Albuminuria / Q000150:complications* / Q000175:diagnosis / Q000652:urine*; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000652:urine; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis / Q000652:urine*; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000652:urine; D008297:Male; D008875:Middle Aged