title: Wound healing after laser skin resurfacing: the effect of a silver sulfadiazine-hyaluronic acid-containing cream under an occlusive dressing.
abstract: BACKGROUND
  Occlusive dressings promote wound healing after laser skin resurfacing. Our goal was to evaluate whether a cream containing hyaluronic acid-silver sulfadiazine could improve this process.
  
  
  METHODS
  Ten guinea pigs received laser resurfacing on the skin of their backs. Polyurethane foam film adhesive dressing was applied. A cream containing hyaluronic acid-silver sulfadiazine was applied under the dressing over half of the wound. Skin biopsies were taken at days 2, 4, 7 and 9 and examined by a pathologist blinded to the study.
  
  
  RESULTS
  Re-epithelialization appeared to occur faster in the cream-treated areas, together with a lower level of acute inflammation in the early phase of the healing process.
  
  
  CONCLUSIONS
  The cream containing silver sulfadiazine/hyaluronic acid seems to improve wound healing after laser skin resurfacing in guinea pigs. The clinical application of this finding on humans should be assessed.
authors.affiliation: Laserlight Clinic, Athens, Greece.
authors.forename: Paraskevas P
authors.initials: PP
authors.lastname: Kontoes
authors.forename: Charis P
authors.initials: CP
authors.lastname: Vrettou
authors.forename: Anastasia N
authors.initials: AN
authors.lastname: Loupatatzi
authors.forename: Konstantinos V
authors.initials: KV
authors.lastname: Marayiannis
authors.forename: Periklis G
authors.initials: PG
authors.lastname: Foukas
authors.forename: Spiros P
authors.initials: SP
authors.lastname: Vlachos
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D004890:Erythema / Q000188:drug therapy / Q000209:etiology; D006168:Guinea Pigs; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000009:adverse effects*; D009779:Occlusive Dressings; D012837:Silver Sulfadiazine / Q000008:administration & dosage / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D006820:Hyaluronic Acid; D012837:Silver Sulfadiazine