Demonstration of three anomalous plasma proteins induced by a vitamin K antagonist.
With the aid of precipitating antibodies against the bovine coagulation factors II, IX, and X three immunologically non-identical proteins can be demonstrated that are induced by the administration of a vitamin K antagonist (phenprocoumon). Each of these proteins is immunologically identical to one of three coagulation factors mentioned. The proteins differ from normal coagulation factors (a) by a lack of biological activity; (b) by a faster anodic migration rate in the presence of Ca2+. The proteins appear in the plasma concomitantly with the decrease of the normal factor.
Reekers
P P
PP
Laboratory for Cardiovascular and Blood Coagulation Biochemistry, Leiden University Medical Centre, Leiden, The Netherlands.
Lindhout
M J
MJ
Kop-Klaassen
B H
BH
Hemker
H C
HC
D000818:Animals; D000906:Antibodies / Q000737:chemistry; D001798:Blood Proteins / Q000737:chemistry*; D002417:Cattle; D002482:Cellulose / Q000737:chemistry; D004563:Electrochemistry / Q000379:methods; D004566:Electrodes; D004587:Electrophoresis, Agar Gel / Q000379:methods; D004983:Ethanolamines / Q000737:chemistry; D005164:Factor IX / Q000737:chemistry; D005170:Factor X / Q000737:chemistry; D006801:Humans; D010644:Phenprocoumon / Q000737:chemistry; D011516:Prothrombin / Q000737:chemistry; D013347:Subcellular Fractions / Q000378:metabolism; D014812:Vitamin K / Q000037:antagonists & inhibitors* / Q000737:chemistry
D000906:Antibodies; D001798:Blood Proteins; D004983:Ethanolamines; D014812:Vitamin K; D011516:Prothrombin; D005164:Factor IX; D005170:Factor X; D002482:Cellulose; D010644:Phenprocoumon; C007369:2-diethylaminoethanol