title: Neuromyelitis optica-IgG (aquaporin-4) autoantibodies in immune mediated optic neuritis.
abstract: The clinical course of immune mediated optic neuritis (ON) will depend on the specific underlying inflammatory disease. These disorders have traditionally been classified according to clinical and MRI findings. Aquaporin-4 (AQP4) autoantibodies (neuromyelitis optica-IgG (NMO-IgG)) may have diagnostic and prognostic value in patients who present with isolated ON. In this prospective study, NMO-IgG was evaluated in 114 patients with ON in the following contexts: neuromyelitis optica (NMO), multiple sclerosis (MSON), chronic relapsing inflammatory ON (CRION), relapsing isolated ON (RION) and single isolated ON (SION). The proportion seropositive was 56% for NMO (n = 9), 0% for MSON (n = 28) and 5% for the remaining diagnostic categories (CRION (n = 19), RION (n = 17) and SION (n = 41)). Testing for NMO-IgG in patients with recurrent or severe ON who lack convincing evidence of MS may identify patients who would benefit from immunosuppression rather than MS directed immunomodulatory therapies.
authors.affiliation: Department of Neuroinflammation, Institute of Neurology, University College London, London, UK. a.petzold@ion.ucl.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Petzold
authors.forename: S
authors.initials: S
authors.lastname: Pittock
authors.forename: V
authors.initials: V
authors.lastname: Lennon
authors.forename: C
authors.initials: C
authors.lastname: Maggiore
authors.forename: B G
authors.initials: BG
authors.lastname: Weinshenker
authors.forename: G T
authors.initials: GT
authors.lastname: Plant
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D051401:Aquaporin 4 / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology; D009187:Myelitis / Q000276:immunology; D009471:Neuromyelitis Optica / Q000276:immunology*; D009902:Optic Neuritis / Q000175:diagnosis / Q000276:immunology*; D011379:Prognosis; D011446:Prospective Studies; D013577:Syndrome; D055815:Young Adult
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D001323:Autoantibodies; D007074:Immunoglobulin G