title: Reverse transcribing the code for chromosome stability.
abstract: The linearity of eukaryotic chromosomes presents challenges to cells, as the presence of DNA "ends" poses problems for the DNA replication machinery and the cell's damage response systems. This year's Nobel Prize in Physiology or Medicine recognized groundbreaking studies establishing the telomere field as a crucial area of biomedical research.
authors.affiliation: Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. sartandi@stanford.edu
authors.forename: Steven E
authors.initials: SE
authors.lastname: Artandi
authors.forename: Julia Promisel
authors.initials: JP
authors.lastname: Cooper
mesh_terms: D043171:Chromosomal Instability; D004261:DNA Replication; D005823:Genetics / Q000266:history*; D049673:History, 20th Century; D006801:Humans; D008938:Mitosis; D008957:Models, Genetic; D009613:Nobel Prize; D019098:Telomerase / Q000266:history* / Q000378:metabolism; D016615:Telomere / Q000502:physiology
chemical_list: D019098:Telomerase