Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination.
BACKGROUND
Genetic polymorphisms play an important role in rubella vaccine-induced immunity.


METHODS
We genotyped 714 healthy children after 2 age-appropriate doses of rubella-containing vaccine for 142 potential single-nucleotide polymorphisms (SNPs).


RESULTS
Specific polymorphisms in the vitamin A receptor, retinoic acid-inducible gene I (RIG-I), and tripartite motif 5 and 22 (TRIM5 and TRIM22) genes were significantly associated with rubella vaccine humoral immunity. The minor allele of the rs4416353 in the vitamin A receptor gene was associated with an allele dose-related decrease (P = .019) in rubella antibody response. The minor allele of rs6793694, in the vitamin A receptor gene, was associated with an allele dose-related antibody decrease (p = .039). The minor variant of nonsynonymous SNP rs10813831 (Arg7Cys) in the RIG-I gene was associated with an allele dose-related decrease in rubella antibody level from 37.4 to 28.0 IU/mL (P = .035), whereas increased representation of the minor allele of the 5'UTR SNP (rs3824949, P = .015) in the antiretroviral TRIM5 gene was associated with an allele dose-related increase in rubella antibody. It is of particular interest that the nonsynonymous SNP rs3740996 (His43Tyr) in the TRIM5 gene was associated with variations in rubella antibody response (P = .016) after having been previously found to play a significant functional role.


CONCLUSIONS
These findings further expand our immunogenetic understanding of mechanisms of rubella vaccine-induced immunity.
Ovsyannikova
Inna G
IG
Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA.
Haralambieva
Iana H
IH
Dhiman
Neelam
N
O'Byrne
Megan M
MM
Pankratz
V Shane
VS
Jacobson
Robert M
RM
Poland
Gregory A
GA
D000293:Adolescent; D000914:Antibodies, Viral / Q000235:genetics*; D000917:Antibody Formation; D000090103:Antiviral Restriction Factors; D002352:Carrier Proteins / Q000235:genetics; D002648:Child; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D008297:Male; D015778:Minor Histocompatibility Antigens; D020641:Polymorphism, Single Nucleotide; D011971:Receptors, Immunologic; D012097:Repressor Proteins / Q000235:genetics; D012411:Rubella Vaccine / Q000276:immunology*; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases; D055815:Young Adult
D000914:Antibodies, Viral; D000090103:Antiviral Restriction Factors; D002352:Carrier Proteins; D015778:Minor Histocompatibility Antigens; D011971:Receptors, Immunologic; D012097:Repressor Proteins; D012411:Rubella Vaccine; C094314:TRIM22 protein, human; D000070584:Tripartite Motif Proteins; C040901:rubella antibodies; C477346:TRIM5 protein, human; D044767:Ubiquitin-Protein Ligases; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases