The sequential building of chiral macrocyclic bis-beta-lactams by double staudinger-Cu-catalyzed azide-alkyne cycloadditions.
A novel approach for the synthesis of macrocyclic bis-beta-lactams based on the Cu-catalyzed alkyne-azide cycloaddition (CuAAC) is reported. The procedure is general and allows access to a full range of diastereomerically or enantiomerically pure macrocyclic cavities in good yields. The incorporation of chiral oxazolidinone fragments at C3 in the beta-lactam rings allows the total enantiocontrol of the process.
Pellico
Daniel
D
Departamento de Química Orgánica, Facultad de Química, Universidad Complutense, 28040 Madrid, Spain.
Gómez-Gallego
Mar
M
Ramírez-López
Pedro
P
Mancheño
María José
MJ
Sierra
Miguel A
MA
Torres
M Rosario
MR