Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process.
A straightforward synthesis of indole-2-carboxylic esters was developed through a ligand-free copper-catalysed condensation/coupling/deformylation cascade process from 2-halo aryl aldehydes or ketones with ethyl isocyanoacetate. The reactions proceeded well for most of the 2-iodo-, bromo-, and chloro-substrates under room temperature or mild conditions.
Cai
Qian
Q
Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine, Health, Chinese Academy of Sciences, Guangzhou International Business Incubator D-10, Guangzhou Science Park, Guangzhou, 510663, China. cai_qian@gibh.ac.cn
Li
Zhengqiu
Z
Wei
Jiajia
J
Ha
Chengyong
C
Pei
Duanqing
D
Ding
Ke
K
D000085:Acetates / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D002264:Carboxylic Acids; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004952:Esters; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D008024:Ligands
D000085:Acetates; D000447:Aldehydes; D002264:Carboxylic Acids; D004952:Esters; D007211:Indoles; D007659:Ketones; D008024:Ligands; C058980:indole-2-carboxylic acid; D003300:Copper; C007170:cyanoacetic acid