title: Serum sex hormones and the 20-year risk of lower urinary tract symptoms in community-dwelling older men.
abstract: OBJECTIVE
  To evaluate serum sex steroid hormone concentrations and long-term risk of subsequent lower urinary tract symptoms (LUTS) in a cohort of community-dwelling older men.
  
  
  METHODS
  Between 1984 and 1987, serum sex hormone concentrations were measured in participants in the Rancho Bernardo Study, a prospective, community-based study. In 2006, the American Urological Association Symptom Index (AUA-SI) was mailed to surviving male participants. Logistic regression was used to examine associations of baseline hormone concentrations with AUA-SI.
  
  
  RESULTS
  Among 158 surviving men with complete data and no history of prostate cancer, the mean (sd) age at serum sex steroid assessment was 58 (6.6) years with a mean (sd) follow-up of 20.3 (0.6) years. In age-adjusted logistic regression, there was a significant inverse association of testosterone : dihydrotestosterone (DHT) with LUTS (P = 0.05). Also, men with higher concentrations of bioavailable testosterone had a 56% decreased risk of LUTS compared with those with hypogonadal concentrations, although the association was not statistically significant (odds ratios 0.44, 95% confidence interval 0.14-1.40) or distributed evenly among quartiles. There were no significant associations of total testosterone, oestradiol (E(2)), testosterone : E(2), DHT, or dehydroepiandrosterone with LUTS or with any measured hormones and urinary bother.
  
  
  CONCLUSIONS
  In this cohort, men with higher mid-life levels of testosterone : DHT and bioavailable testosterone had a decreased 20-year risk of LUTS. These data support other studies reporting inverse associations of serum testosterone with LUTS. Clinical trials of testosterone therapy should include LUTS and clinical benign prostatic hyperplasia as outcomes.
authors.affiliation: Division of Urologic Oncology, Moores UCSD Cancer Center, San Diego, CA, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Trifiro
authors.forename: J Kellogg
authors.initials: JK
authors.lastname: Parsons
authors.forename: Kerrin
authors.initials: K
authors.lastname: Palazzi-Churas
authors.forename: Jaclyn
authors.initials: J
authors.lastname: Bergstrom
authors.forename: Charles
authors.initials: C
authors.lastname: Lakin
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Barrett-Connor
mesh_terms: D002140:California; D013196:Dihydrotestosterone / Q000097:blood*; D004812:Epidemiologic Methods; D006801:Humans; D007006:Hypogonadism / Q000097:blood; D057187:Independent Living; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000097:blood*; D053448:Prostatism / Q000097:blood*; D013739:Testosterone / Q000097:blood*
chemical_list: D013196:Dihydrotestosterone; D013739:Testosterone