Terminology of developmental abnormalities in common laboratory mammals (version 2).
This update (Version 2) of the Terminology of Developmental Abnormalities in Common Laboratory Mammals (Version 1) incorporates improvements and enhancements to both content and organization of the terminology to enable greater flexibility in its application, while maintaining a consistent approach to the description of findings. The revisions are the result of an international collaboration among interested organizations, advised by individual experts and the outcomes of several workshops. The terminology remains organized into tables under the broad categories of external, visceral, and skeletal observations, following the manner in which data are typically collected and recorded in developmental toxicity studies. This arrangement of the tables, as well as other information provided in appendices, is intended to facilitate the process of specimen evaluation at the laboratory bench level. Only the commonly used laboratory mammals (i.e. rats, mice, rabbits) are addressed in the current terminology tables. The inclusion of other species that are used in developmental toxicity testing, such as primates, is considered outside the scope of the present update. Similarly, categorization of findings as, for example, 'malformation' or 'variation' remains unaddressed, in accordance with the overall principle that the focus of this document is descriptive terminology and not diagnosis or interpretation. The skeletal terms have been augmented to accommodate cartilage findings.
Makris
Susan L
SL
US Environmental Protection Agency, Washington, DC 20460-0001, USA. makris.susan@epa.gov
Solomon
Howard M
HM
Clark
Ruth
R
Shiota
Kohei
K
Barbellion
Stephane
S
Buschmann
Jochen
J
Ema
Makoto
M
Fujiwara
Michio
M
Grote
Konstanze
K
Hazelden
Keith P
KP
Hew
Kok Wah
KW
Horimoto
Masao
M
Ooshima
Yojiro
Y
Parkinson
Meg
M
Wise
L David
LD
D000818:Animals; D000830:Animals, Laboratory / Q000002:abnormalities*; D008322:Mammals; D009626:Terminology as Topic