title: Lethal neuroendocrine carcinoma in ulcerative colitis.
abstract: A 48-year old male with longstanding and extensive pancolitis developed a high grade and rapidly lethal malignant lesion in the ascending colon characterized by a neuroendocrine carcinoma. Prior biopsies obtained from multiple sites in the colon during endoscopic surveillance were reported to show only inflammatory changes without dysplasia. Although operator-dependent, repeated endoscopic studies may have limitations during surveillance programs because the biological behavior of some colonic neoplastic lesions may have a rapid and very aggressive clinical course.
authors.forename: Hugh J
authors.initials: HJ
authors.lastname: Freeman
authors.forename: Ken
authors.initials: K
authors.lastname: Berean
mesh_terms: D001706:Biopsy; D003093:Colitis, Ulcerative / Q000150:complications / Q000473:pathology; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000209:etiology / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D007249:Inflammation / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged