Synthesis and characterization of stigmasterol oxidation products.
The synthesis and structural characterization of a series of oxides of stigmasterol is described providing a valuable series of reference standards for these oxides, analogous to the cholesterol oxidation products (COPs) which have been shown to have detrimental biological effects. Biological evaluation of the oxides of phytosterols is significant in the context of increased dietary use of phytosterols in the drive to reduce cholesterol absorption.
Foley
David A
DA
Department of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland.
O'Callaghan
Yvonne
Y
O'Brien
Nora M
NM
McCarthy
Florence O
FO
Maguire
Anita R
AR
D010084:Oxidation-Reduction; D013265:Stigmasterol / Q000138:chemical synthesis* / Q000737:chemistry*
D013265:Stigmasterol