Challenges in umbilical cord blood stem cell banking for stem cell reviews and reports.
Twenty years has passed since the first report of a successful cord blood transplant was reported in 1989 in a child with Fanconi's anemia. During these 20 years, the cord blood field has had dramatic growth, with over 400,000 cord blood units donated and stored worldwide for unrelated use. Approximately, 14,000 unrelated cord blood transplants have been performed to date for patients with hematologic malignancies and bone marrow disorders, and who do not have matched family or unrelated donors. In contrast, about 900,000 cord blood units have been stored privately for personal use, with about 100 autologous transplants performed. Twenty years ago, due to the low cell dose, cord blood transplants were only performed in children. Today, with the use of better banking techniques, reduced intensity transplants, and double cord blood transplantation, the majority of cord blood transplants are being performed in adults. In this chapter, we review the scientific basis for cord blood transplantation, and outcome data in both pediatric and adult transplantation. We will then focus on the recent concerns regarding private and public cord blood banking. Finally, we discuss the future of cord blood transplantation, and the exciting work beginning outside of oncology.
Ballen
Karen
K
Division of Hematology/Oncology, Department of Medicine, Massachusetts General Hospital, Zero Emerson, Suite 118, Boston, MA, 02214, USA. kballen@partners.org
D000328:Adult; D000818:Animals; D001771:Blood Banks / Q000458:organization & administration / Q000639:trends; D001782:Blood Donors / Q000600:supply & distribution; D002648:Child; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects / Q000639:trends; D005312:Fetal Blood / Q000166:cytology*; D006801:Humans; D017149:Private Sector / Q000458:organization & administration / Q000639:trends; D017150:Public Sector / Q000458:organization & administration / Q000639:trends; D018570:Risk Assessment; D013048:Specimen Handling / Q000639:trends; D016896:Treatment Outcome