Evidence for the involvement of glutamatergic and neurokinin 1 receptors in the antinociception elicited by tramadol in mice.
This study was designed to evaluate the role of spinal glutamatergic receptors and neurokinin 1-mediated pathway in the antinociception elicited by tramadol in mice. Tramadol (1-50 mg/kg), given intraperitoneally (i.p.), produced significant inhibition of the biting behavior induced by intrathecal injection (i.t.) of glutamate (175 nmol/site), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA; 135 pmol/site), (+/-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (trans-ACPD; 50 nmol/site) and substance P (SP, 135 ng/site). Tramadol injected by the i.t. route (25-400 nmol/site) also produced inhibition of glutamate-, AMPA-, trans-ACPD- and SP-induced biting response. Pretreatment with tramadol by the i.p. and i.t. routes had no significant effect against the kainate- and N-methyl-D-aspartic acid (NMDA)-mediated biting response in mice.
Jesse
Cristiano R
CR
Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, Brazil. criswn @ quimica.ufsm.br
Nogueira
Cristina W
CW
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001733:Bites and Stings; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology; D010147:Pain Measurement; D017470:Receptors, Glutamate / Q000378:metabolism*; D018040:Receptors, Neurokinin-1 / Q000378:metabolism*; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism; D014147:Tramadol / Q000008:administration & dosage / Q000494:pharmacology*
D000701:Analgesics, Opioid; D017470:Receptors, Glutamate; D018040:Receptors, Neurokinin-1; D014147:Tramadol