title: MMP-9 (gelatinase B) expression is associated with disease-free survival and disease-specific survival in colorectal cancer patients.
abstract: Extracellular matrix degradation is required for invasion and metastasis formation in colorectal carcinoma (CRC), therefore, we have examined matrix metalloproteinases MMP-9 expression in tumors from patients with CRC. The study comprises of 360 patients who underwent bowel resection for stage II, III, IV tumors. Paraffin-embedded CRC tissue samples were used for immunohistochemical staining. Negative MMP-9 expression levels correlated with longer survival time as evaluated by disease-free survival and disease-specific survival (p =.023, p =.006). In multivariate survival (Cox) analysis, MMP9 was a significant independent predictor of DFS (p =.014), but not of DSS, which was independently predicted by disease recurrence, stage and localization. The detection of MMP-9 expression may be valuable in finding patients who are at high risk of developing disease recurrence.
authors.affiliation: Department of Oncology and Radiotherapy, Turku University Hospital, and University of Turku, Turku, Finland. riyben@utu.fi
authors.forename: Riyad
authors.initials: R
authors.lastname: Bendardaf
authors.forename: Abdelbaset
authors.initials: A
authors.lastname: Buhmeida
authors.forename: Marja
authors.initials: M
authors.lastname: Hilska
authors.forename: Matti
authors.initials: M
authors.lastname: Laato
authors.forename: Stina
authors.initials: S
authors.lastname: Syrjänen
authors.forename: Kari
authors.initials: K
authors.lastname: Syrjänen
authors.forename: Yrjö
authors.initials: Y
authors.lastname: Collan
authors.forename: Seppo
authors.initials: S
authors.lastname: Pyrhönen
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000201:enzymology* / Q000401:mortality* / Q000556:secondary / Q000601:surgery; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000401:mortality* / Q000556:secondary / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000032:analysis*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016017:Odds Ratio; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D018570:Risk Assessment; D013997:Time Factors; D046888:Tissue Array Analysis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D020780:Matrix Metalloproteinase 9