title: [Lifestyle-related diseases and H. pylori].
abstract: H. pylori infection elicits a chronic cellular inflammatory response not only in the gastric mucosa, but also in the extra-digestive organs. Indeed, H. pylori infection has been epidemiologically linked to the extra-digestive conditions and diseases. In this article, we review recent progress in our understanding about the relationship between H. pylori infection and lifestyle-related diseases, such as atherosclerosis, diabetes mellitus, obesity, hyperlipidemia, hypertension, and osteoporosis. Although the relationships between all of these diseases and H. pylori infection are still controversial, H. pylori infection may increase the risk for cardiovascular and cerebrovascular diseases, especially when CagA+ cytotoxic strains of H. pylori are present.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Juntaro
authors.initials: J
authors.lastname: Matsuzaki
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Hibi
mesh_terms: D001161:Arteriosclerosis / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology*; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D006949:Hyperlipidemias / Q000209:etiology; D008019:Life Style; D009765:Obesity / Q000209:etiology*