Peanut consumption and cardiovascular risk.
OBJECTIVE
We evaluated the effects of peanut consumption on lipid profiles, atherogenic index of plasma (AIP) and CHD risk in hypercholesterolaemic men.


METHODS
Randomised crossover clinical trial.


METHODS
Participants were randomly assigned to two groups. They were asked to consume peanut supplements (about 77 g) with their habitual diet for 4 weeks.


METHODS
Fifty-four hypercholesterolaemic men with total cholesterol (TC) concentrations between 200 and 350 mg/dl.


RESULTS
Compared with the habitual diet, peanut supplementation of the habitual diet significantly reduced TC/HDL cholesterol (HDL-C) ratio (mean 1 (se 0.3) P = 0.001) and LDL cholesterol (LDL-C)/HDL-C ratio (mean 0.7 (se 0.2); P = 0.001). Peanut consumption increased HDL-C (mean 6.1 (se 1.5) mg/dl; P < 0.001) and total antioxidant capacity (TAC) (mean 1.2 (se 0.6) U/mL P = 0.04). In addition, peanut consumption significantly reduced the AIP (mean 0.1 (se 0.03) P = 0.01) and CHD estimated risk over 10 years based on systolic and diastolic blood pressures (mean 1.4 % (se 0.5 %) P = 0.004 and mean 2.2 % (se 0.5 %) P < 0.001, respectively).


CONCLUSIONS
Short-term peanut consumption might improve lipid profiles, the AIP and CHD risk in free-living hypercholesterolaemic men.
Ghadimi Nouran
Mina
M
Department of Human Nutrition, National Nutrition and Food Technology Research Institute, Shahid Beheshti University MC, Tehran, Iran. mina_ghadimi@yahoo.com
Kimiagar
Masoud
M
Abadi
Alireza
A
Mirzazadeh
Majid
M
Harrison
Gail
G
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D010367:Arachis; D050197:Atherosclerosis / Q000097:blood / Q000517:prevention & control*; D001794:Blood Pressure / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood*; D018592:Cross-Over Studies; D019587:Dietary Supplements; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy*; D008297:Male; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use*; D012307:Risk Factors; D012639:Seeds
D000975:Antioxidants; D028321:Plant Preparations; D002784:Cholesterol