title: Correlation between interleukin 6 and interleukin 10 in acute myocardial infarction.
abstract: The aim of this study was to analyze (i) ratios between pro-inflammatory cytokines interleukin 6 (IL-6), interleukin 1 (IL-1), tumour necrosis factor alpha (TNF-alpha) and anti-inflammatory cytokine interleukin 10 (IL-10) in patients with acute myocardial infarction (AMI) and stable angina pectoris (ii) as well as correlation between IL-6 and IL-10 in AMI and (iii) correlation between IL-6 and lipoproteins in AMI.The total of 71 patients were enrolled in this study, 41 of them with AMI (study group) and 30 with stable angina pectoris (control group). The concentrations of cytokines and lipoproteins were measured from blood samples. Pro-inflammatory to anti-inflammatory cytokine ratios were calculated by dividing concentrations of pro-inflammatory cytokines with IL-10. In statistical analyses we used descriptive statistics, normality tests and analysis of correlation.IL-6: IL-10 ratio is significantly higher in AMI than in stable angina (P < 0,001), TNF-alpha: IL-10 is also higher in study group but the difference is not significant. We found positive linear correlation between IL-6 and IL-10 (r =0,43; p = 0,015) and negative linear correlation between IL-6 and high density lipoprotein HDL (r = -0,47; p= 0,008) in AMI.IL-6: IL-10 ratio is higher in AMI than in stable angina. There is linear correlation between IL-6 and IL-10 and IL-6 and HDL in AMI.
authors.affiliation: Department of Cardiology, Clinic of Internal Medicine, University Clinics Centre Tuzla, Trnovac bb, 75000 Tuzla, Bosnia and Herzegovina.
authors.forename: Larisa
authors.initials: L
authors.lastname: Dizdarević-Hudić
authors.forename: Zumreta
authors.initials: Z
authors.lastname: Kusljugić
authors.forename: Fahir
authors.initials: F
authors.lastname: Baraković
authors.forename: Selmira
authors.initials: S
authors.lastname: Brkić
authors.forename: Damir
authors.initials: D
authors.lastname: Sabitović
authors.forename: Elmir
authors.initials: E
authors.lastname: Jahić
authors.forename: Maida
authors.initials: M
authors.lastname: Isabegović
authors.forename: Elnur
authors.initials: E
authors.lastname: Smajić
authors.forename: Igor
authors.initials: I
authors.lastname: Hudić
authors.forename: Katarina
authors.initials: K
authors.lastname: Divković
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D007375:Interleukin-1 / Q000097:blood; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D011446:Prospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D002097:C-Reactive Protein