[Dendritic cells in hypertrophied adenoid at children with otitis media with effusion].
BACKGROUND
The adenoids are organized as lymphoepithelial structures that play an important role in protecting both the upper respiratory and alimentary tract regions. This functions requires dendritic cells (DC) which are one of the major populations of immune cells. Due to the presence of specific receptors (DC) are able to respond to both intra- and extracellular antigens. Dendritic cells activating immunological response in tonsil contribute formation immunologic competent cells on necessity of rolling inflammatory process in middle ear.


OBJECTIVE
An investigation was executed in hypertrophied adenoids with or without otitis media with effusion.


METHODS
By flow cytometry percentage of CD11c+ myeloid DC and 123+ plasmacytoid DC in hypertrophied adenoid and hypertrophied adenoid and otitis media with effusion was analyzed.


RESULTS
The percentage of CD11c+ myeloid DC and 123+ plasmacytoid DC was similar in hypertrophied adenoid and otitis media with effusion compored to the control group.


CONCLUSIONS
Our data show that part of dendritic cells has not on course of inflammatory process influence rolling in middle ear.
Zelazowska-Rutkowska
Beata
B
Zakład Laboratoryjnej Diagnostyki Pediatrycznej Uniwersytetu Medycznego w Białymstoku. zelazowskab@wp.pl
Ratomski
Karol
K
Wysocka
Jolanta
J
Kasprzycka
Edwina
E
Hassmann-Poznańska
Elzbieta
E
Mrugacz
Małgorzata
M
D000234:Adenoids / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D018941:Antigens, CD19 / Q000378:metabolism; D001402:B-Lymphocytes / Q000378:metabolism; D018956:CD5 Antigens / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003713:Dendritic Cells / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D006984:Hypertrophy / Q000276:immunology; D008297:Male; D010034:Otitis Media with Effusion / Q000276:immunology* / Q000601:surgery*; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
D018941:Antigens, CD19; D018956:CD5 Antigens