title: The treatment of deep dermal hand burns: How do we achieve better results? Should we use allogeneic keratinocytes or skin grafts?
abstract: The treatment of deep dermal burns has a broad spectrum and has been subject to discussion over the past years. The treatment of hand burns is challenging due to the high requirements to aesthetic and functional outcome. 27 patients, 7 women and 20 men with deep dermal hand burns with a mean age of 41.3+/-16.5 and a mean TBSA of 15%+/-19.6% were treated either with allogeneic cryopreserved keratinocytes or with split skin grafts. Long-term follow-up revealed no statistical significant differences between the two groups concerning Vancouver Scar Scale as well as hand function judged by the DASH score; however there was a tendency to higher VSS scores and impaired aesthetic results in the keratinocyte group. Allogeneic keratinocytes are a suitable armentarium for the treatment of deep dermal hand burns; and, if used correctly, they can produce a timely healing comparable to split-thickness skin grafts. Limited availability, high costs as well as the need for special skills are key factors, which render application of this technique outside specialist burn centres virtually impossible. In our opinion, the cultivation and use of keratinocytes should be reserved to these centres in order to facilitate a sensible application for a full range of indications. We recommend usage of allogeneic keratinocytes for deep dermal hand burns only in severely burned patients with a lack of donor sites. Patients with unrestricted availability of donor sites seem to profit from the application of split-thickness skin grafts according to our results.
authors.affiliation: Vienna Burn Centre, Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Haslik
authors.forename: L-P
authors.initials: LP
authors.lastname: Kamolz
authors.forename: D B
authors.initials: DB
authors.lastname: Lumenta
authors.forename: M
authors.initials: M
authors.lastname: Hladik
authors.forename: H
authors.initials: H
authors.lastname: Beck
authors.forename: M
authors.initials: M
authors.lastname: Frey
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002056:Burns / Q000473:pathology / Q000601:surgery*; D004954:Esthetics; D005260:Female; D005384:Finger Joint / Q000503:physiopathology; D005500:Follow-Up Studies; D006230:Hand Injuries / Q000473:pathology / Q000601:surgery*; D006801:Humans; D015603:Keratinocytes / Q000637:transplantation*; D008297:Male; D008875:Middle Aged; D016059:Range of Motion, Articular; D016038:Skin Transplantation / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult