Promoter architecture and the evolvability of gene expression.
Evolutionary changes in gene expression are a main driver of phenotypic evolution. In yeast, genes that have rapidly diverged in expression are associated with particular promoter features, including the presence of a TATA box, a nucleosome-covered promoter and unstable tracts of tandem repeats. Here, we discuss how these promoter properties may confer an inherent capacity for flexibility of expression.
Tirosh
Itay
I
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel. itay.tirosh@weizmann.ac.il
Barkai
Naama
N
Verstrepen
Kevin J
KJ
D000818:Animals; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D006801:Humans; D010641:Phenotype; D011401:Promoter Regions, Genetic / Q000235:genetics*; D016385:TATA Box / Q000235:genetics