Transition-metal-catalyzed direct arylation of (hetero)arenes by C-H bond cleavage.
The area of transition-metal-catalyzed direct arylation through cleavage of C-H bonds has undergone rapid development in recent years, and is becoming an increasingly viable alternative to traditional cross-coupling reactions with organometallic reagents. In particular, palladium and ruthenium catalysts have been described that enable the direct arylation of (hetero)arenes with challenging coupling partners--including electrophilic aryl chlorides and tosylates as well as simple arenes in cross-dehydrogenative arylations. Furthermore, less expensive copper, iron, and nickel complexes were recently shown to be effective for economically attractive direct arylations.
Ackermann
Lutz
L
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077 Göttingen, Germany. lutz.ackermann@chemie.uni-goettingen.de
Vicente
Rubén
R
Kapdi
Anant R
AR
D001713:Biphenyl Compounds / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D009942:Organometallic Compounds / Q000737:chemistry; D013237:Stereoisomerism; D028561:Transition Elements / Q000737:chemistry*
D001713:Biphenyl Compounds; D009942:Organometallic Compounds; D028561:Transition Elements; C010574:biphenyl