[Recent proceedings in epigenetics research of lung cancer].
Epigenetics is a mechanism of reversible and heritable regulation of gene transcription in contrast to genetic or DNA-coding information. In higher vertebrae, epigenetics consist of methylation of cytosine and histone modification. Mainly as detection is easier, aberrant DNA methylation was studied since the middle of '80s and recently convenient kit makes easy for study of histone modification. DNA methylation and histone modification meet in the end of '90s and regulation of transcription has being revealed. In this review, a history of epigenetics is commented briefly and recent proceedings of epigenetic change in lung cancer including micro RNA inactivation by DNA methylation and multigenetic analyses in non-small cell lung cancer is discussed.
Takai
Daiya
D
Department of Clinical Laboratory, The University of Tokyo Hospital.
D000818:Animals; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics
D035683:MicroRNAs