title: Conserved genetic pathways controlling the development of the diffuse endocrine system in vertebrates and Drosophila.
abstract: The midgut epithelium is formed by absorptive enterocytes, secretory cells and endocrine cells. Each of these lineages is derived from the pluripotent progenitors that constitute the embryonic endoderm; the mature midgut retains pools of self-renewing stem cells that continue to produce all lineages. Recent findings in vertebrates and Drosophila shed light on the genetic mechanism that specifies the fate of the different lineages. A pivotal role is played by the Notch signaling pathway that, in a manner that appears to be very similar to the way in which Notch signaling selects neural progenitors within the neurectoderm, distinguishes the fate of secretory/endocrine cells and enterocytes. Proneural genes encoding bHLH transcription factors are expressed and required in prospective endocrine cells; activation of the Notch pathways restricts the number of these cells and promotes enterocyte development. In this review we compare the development of the intestinal endocrine cells in vertebrates and insects and summarize recent findings dealing with genetic pathways controlling this cell type.
authors.affiliation: Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA. volkerh@mcdb.ucla.edu
authors.forename: Volker
authors.initials: V
authors.lastname: Hartenstein
authors.forename: Shigeo
authors.initials: S
authors.lastname: Takashima
authors.forename: Katrina L
authors.initials: KL
authors.lastname: Adams
mesh_terms: D000818:Animals; D004330:Drosophila / Q000166:cytology / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism; D004703:Endocrine System / Q000166:cytology / Q000378:metabolism*; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D014714:Vertebrates / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D051880:Receptors, Notch