Synthesis and antileishmanial activity of lipidic amino alcohols.
In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC(50) below 10 microm. Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms.
Coimbra
Elaine S
ES
Departamento de Parasitologia, Microbiologia e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Cidade Universitária, MG, Brazil.
de Almeida
Mauro V
MV
Júnior
Celso O R
CO
Taveira
Aline F
AF
da Costa
Cristiane F
CF
de Almeida
Ana C
AC
Reis
Elaine F C
EF
da Silva
Adilson D
AD
D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000666:Amphotericin B / Q000494:pharmacology; D006801:Humans; D007891:Leishmania / Q000187:drug effects* / Q000254:growth & development; D014344:Trypanocidal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000605:Amino Alcohols; D014344:Trypanocidal Agents; D000666:Amphotericin B