title: D-cycloserine and cocaine cue reactivity: preliminary findings.
abstract: BACKGROUND
  D-cycloserine (DCS), a partial glutamate N-methyl-D-aspartic acid (NMDA) receptor agonist, enhances extinction of conditioned fear responding in rodents and facilitates exposure-based learning in humans with anxiety disorders.
  
  
  OBJECTIVE
  This preliminary study investigates DCS pretreatment on response to cocaine cues in cocaine-dependent subjects.
  
  
  METHODS
  Ten cocaine-dependent subjects were randomly assigned to receive either 50 mg DCS or matching placebo two hours before each of two 1-hour cocaine cue exposure sessions one day apart. HR and craving ratings were obtained before and during cue exposure sessions.
  
  
  RESULTS
  There was a trend towards increased craving to cocaine cues in cocaine-dependent individuals after administration of DCS.
  
  
  CONCLUSIONS
  The administration of DCS prior to cue exposure sessions may facilitate response activation.
  
  
  CONCLUSIONS
  While facilitation of extinction-based learning by DCS may have therapeutic potential for cocaine dependence, this drug may exhibit a different profile in cocaine-dependent individuals as compared to those with anxiety disorders.
authors.affiliation: Medical University of South Carolina, Department of Psychiatry, Clinical Neuroscience Division, 67 President Street, Charleston, SC 29425, USA. pricekl@musc.edu
authors.forename: Kimber L
authors.initials: KL
authors.lastname: Price
authors.forename: Aimee L
authors.initials: AL
authors.lastname: McRae-Clark
authors.forename: Michael E
authors.initials: ME
authors.lastname: Saladin
authors.forename: Megan M Moran-Santa
authors.initials: MM
authors.lastname: Maria
authors.forename: Stacia M
authors.initials: SM
authors.lastname: DeSantis
authors.forename: Sudie E
authors.initials: SE
authors.lastname: Back
authors.forename: Kathleen T
authors.initials: KT
authors.lastname: Brady
mesh_terms: D000293:Adolescent; D000328:Adult; D016739:Behavior, Addictive / Q000188:drug therapy*; D003042:Cocaine / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000188:drug therapy*; D003463:Cues; D003523:Cycloserine / Q000627:therapeutic use*; D005108:Extinction, Psychological / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D010865:Pilot Projects; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists*
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D003523:Cycloserine; D003042:Cocaine