title: Anti-annexin A5 antibodies in women with spontaneous pregnancy loss.
abstract: OBJECTIVE
  The aim was to evaluate the role of anti-annexin A5 (anti-ANXA5) antibodies as risk factor for recurrent miscarriage (RM) and unexplained fetal loss (UFL).
  
  
  METHODS
  Retrospective, cohort study.
  
  
  METHODS
  Vall d'Hebron University Hospital.
  
  
  METHODS
  122 women, in two groups:
  
  
  METHODS
  54 women with RM/UFL and control group: 68 pregnant without RM/UFL.
  
  
  METHODS
  Antiphospholipid, mainly anti-ANXA5 antibody analysis. Comparison of all antiphospholipid antibodies between groups.
  
  
  RESULTS
  Antiphospholipid antibody (aPL) prevalence in the study group was 10/54 (14.8%) and 5/68 (7.3%) in control group (p=0.09). In the RM subgroup, it was 3/25 and 9/34 in UFL versus 5/68 in controls (p=0.013). Lupus anticoagulant (LA) was present in 4 cases, all belonging to the study group (p=0.011). Four out of 34 women with UFL were positive for anticardiolipin antibodies-IgG (IgG-aCL) versus 1/68 in controls (p=0.041). In RM subgroup, anti-ANXA5 antibodies were positive in 2/25 versus 3/68 in controls, and in UFL subgroup, 3/34 versus 3/68 cases (p=1.000).
  
  
  CONCLUSIONS
  According to our results, anti-ANXA5 antibodies should not be considered as a risk factor for RM/UFL.
authors.affiliation: Systemic Autoimmune Disease Unit, Department of Internal Medicine I, Hospital Universitari Vall d'Hebron, Department of Medicine, Universitat Autonoma, Barcelona, Spain. jalijotas@vhebron.net
authors.forename: Jaume
authors.initials: J
authors.lastname: Alijotas-Reig
authors.forename: Raquel
authors.initials: R
authors.lastname: Ferrer-Oliveras
authors.forename: María José
authors.initials: MJ
authors.lastname: Rodrigo-Anoro
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Farran-Codina
authors.forename: Elisa
authors.initials: E
authors.lastname: Llurba-Olivé
authors.forename: Miquel
authors.initials: M
authors.lastname: Vilardell-Tarres
authors.forename: Manel
authors.initials: M
authors.lastname: Casellas-Caro
mesh_terms: D000022:Abortion, Spontaneous / Q000276:immunology*; D017304:Annexin A5 / Q000276:immunology*; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D016736:Antiphospholipid Syndrome / Q000276:immunology; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D011247:Pregnancy; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D017304:Annexin A5; D017152:Antibodies, Antiphospholipid; D016682:Lupus Coagulation Inhibitor