title: Verteporfin photodynamic therapy of retinal capillary hemangioblastoma in von Hippel-Lindau disease.
abstract: An 18-year-old boy presented to us with bilateral retinal hemangioblastoma and von Hippel-Lindau disease with history of cerebral capillary hemangioblastoma and embryonic cell carcinoma of left testes. The vision in the right eye was already lost with development of secondary closed angle glaucoma, optic atrophy with subsequent development of bullous keratopathy. The multiple retinal angiomatous lesions in the seeing left eye were treated with various modalities like triple freeze thaw cryopexy, focal lasers and transpupillary thermo therapy in multiple sittings over a period of almost 20 years since detection. One particular angiomatous lesion in the left eye was showing resistance to all the above mentioned modalities and was finally successfully treated with verteporfin and photodynamic therapy to achieve complete regression without any post-treatment complication and with a sustained 20/20 vision till a follow-up of 15 months.
authors.affiliation: Vitreo-Retinal Services, Sri Sankaradeva Nethralaya, Beltola, Assam, India.
authors.forename: Harsha
authors.initials: H
authors.lastname: Bhattacharjee
authors.forename: Hemalata
authors.initials: H
authors.lastname: Deka
authors.forename: Satyen
authors.initials: S
authors.lastname: Deka
authors.forename: Manab Jyoti
authors.initials: MJ
authors.lastname: Barman
authors.forename: Mrinal
authors.initials: M
authors.lastname: Mazumdar
authors.forename: Jnanankar
authors.initials: J
authors.lastname: Medhi
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D018325:Hemangioblastoma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011166:Porphyrins / Q000627:therapeutic use*; D019572:Retinal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D013997:Time Factors; D000077362:Verteporfin; D006623:von Hippel-Lindau Disease / Q000150:complications* / Q000175:diagnosis
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin