Hemoglobin bis-tetramers via cooperative azide-alkyne coupling.
Cross-linked hemoglobin-azides react with a bis-alkyne to form a bis-tetramer through sequential "click" reactions where the second step is promoted by the first.
Foot
Jonathan S
JS
Davenport Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario, Canada M5S 3H6.
Lui
Francine E
FE
Kluger
Ronald
R
D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006454:Hemoglobins / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D055503:Protein Multimerization; D055550:Protein Stability; D012995:Solubility
D000480:Alkynes; D001386:Azides; D003432:Cross-Linking Reagents; D006454:Hemoglobins