Genome-wide association and linkage analysis of quantitative traits: comparison of likelihood-ratio test and conditional score statistic.
Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a specific phenotype. Because linkage and association analysis provide complementary information, developing a method to combine these analyses may increase the power to detect a true association. In this paper we compare a linkage score and association score test as well as a newly proposed combination of these two scores with traditional linkage and association methods.
Hendricks
Audrey E
AE
Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Talbot Building, Boston, Massachusetts 02118 USA. baera@bu.edu.
Zhu
Yanyan
Y
Dupuis
Josée
J