title: Alterations of resting state functional connectivity in the default network in adolescents with autism spectrum disorders.
abstract: Autism spectrum disorders (ASD) are associated with disturbances of neural connectivity. Functional connectivity between neural structures is typically examined within the context of a cognitive task, but also exists in the absence of a task (i.e., "rest"). Connectivity during rest is particularly active in a set of structures called the default network, which includes the posterior cingulate cortex (PCC), retrosplenial cortex, lateral parietal cortex/angular gyrus, medial prefrontal cortex, superior frontal gyrus, temporal lobe, and parahippocampal gyrus. We previously reported that adults with ASD relative to controls show areas of stronger and weaker connectivity within the default network. The objective of the present study was to examine the default network in adolescents with ASD. Sixteen adolescents with ASD and 15 controls participated in a functional MRI study. Functional connectivity was examined between a PCC seed and other areas of the default network. Both groups showed connectivity in the default network. Relative to controls, adolescents with ASD showed widespread weaker connectivity in nine of the eleven areas of the default network. Moreover, an analysis of symptom severity indicated that poorer social skills and increases in restricted and repetitive behaviors and interests correlated with weaker connectivity, whereas poorer verbal and non-verbal communication correlated with stronger connectivity in multiple areas of the default network. These findings indicate that adolescents with ASD show weaker connectivity in the default network than previously reported in adults with ASD. The findings also show that weaker connectivity within the default network is associated with specific impairments in ASD.
authors.affiliation: Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA. wengjen@u.washington.edu
authors.forename: Shih-Jen
authors.initials: SJ
authors.lastname: Weng
authors.forename: Jillian Lee
authors.initials: JL
authors.lastname: Wiggins
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Peltier
authors.forename: Melisa
authors.initials: M
authors.lastname: Carrasco
authors.forename: Susan
authors.initials: S
authors.lastname: Risi
authors.forename: Catherine
authors.initials: C
authors.lastname: Lord
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Monk
mesh_terms: D000293:Adolescent; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000188:drug therapy / Q000503:physiopathology*; D003071:Cognition; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000187:drug effects / Q000503:physiopathology; D012146:Rest; D012720:Severity of Illness Index