Gold-catalyzed cyclization of alkynylaziridines as an efficient approach toward functionalized N-phth pyrroles.
An efficient access to N-phth pyrrroles via gold-catalyzed cycloisomerization of N-phth alkynylaziridines has been described. Functionalized pyrroles including pyrrole-2-carboxylates or 2-pyrrolyl ketone are easily constructed in generally good yields by this method. The resulting pyrroles can be further converted to N-amino pyrrole or 2-acyl pyrrole, which are important synthetic intermediates for amplification of molecular complexity.
Du
Xiangwei
X
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, People's Republic of China.
Xie
Xin
X
Liu
Yuanhong
Y
D000480:Alkynes / Q000737:chemistry*; D001388:Aziridines / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D015394:Molecular Structure; D010795:Phthalic Acids / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
D000480:Alkynes; D001388:Aziridines; D010795:Phthalic Acids; D011758:Pyrroles; D006046:Gold