Neglected tropical diseases.
BACKGROUND
The neglected tropical diseases (NTDs) are infectious diseases that principally impact the world's poorest people. They have been neglected for decades, initially as part of a general disregard for the developing world, and more recently due to the intensity of focus on HIV/AIDS, tuberculosis and malaria.


METHODS
Primary research and review articles were selected for inclusion using searches of PubMed and our existing collections.


RESULTS
There have been recent notable successes in NTD control. Dracunculiasis is approaching eradication. Leprosy and onchocerciasis are in decline. There are ambitious plans to eliminate trachoma and lymphatic filariasis. Investment in NTD control has high rates of economic return.


CONCLUSIONS
Although there are proven strategies to control several NTDs, these diseases continue to cause a massive burden of morbidity. There is urgent need for more basic and operational research, drug and vaccine development, and greater prioritization by governments and international agencies.
Feasey
Nick
N
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St., London, UK.
Wansbrough-Jones
Mark
M
Mabey
David C W
DC
Solomon
Anthony W
AW
D000818:Animals; D003141:Communicable Diseases / Q000453:epidemiology*; D003906:Developing Countries; D019353:Endemic Diseases / Q000706:statistics & numerical data; D006801:Humans; D010272:Parasitic Diseases / Q000453:epidemiology*; D011203:Poverty; D014329:Tropical Climate; D014330:Tropical Medicine / Q000379:methods*