Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors.
The aim of this work was to study the immunohistochemical expression of androgen receptor, estrogen receptor and progesterone receptor in pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas of salivary glands. A total of 41 pleomorphic adenomas, 30 Warthin's tumors, 30 mucoepidermoid carcinomas and 30 adenoid cystic carcinomas were analyzed, and the immunohistochemical expression of these hormone receptors were assessed. It was observed that all cases were negative for estrogen and progesterone receptors. Androgen receptor was positive in 2 cases each of pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. In conclusion, the results do not support a role of estrogen and progesterone in the tumorigenesis of pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas. However, androgen receptors can play a role in a small set of salivary gland tumors, and this would deserve further studies.
Ito
Fabio Augusto
FA
Department of Pathology, Londrina State University, Londrina, PR, Brazil.
Ito
Kazuhiro
K
Coletta
Ricardo Della
RD
Vargas
Pablo Agustín
PA
Lopes
Márcio Ajudarte
MA
D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018193:Neoplasms, Complex and Mixed / Q000737:chemistry / Q000473:pathology*; D011944:Receptors, Androgen / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000473:pathology*; D055815:Young Adult
D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone