Stereoselective synthesis of trans-beta-lactams by palladium-catalysed carbonylation of vinyl aziridines.
The palladium-catalysed carbonylation of vinyl aziridines can give either the trans- or cis-beta-lactam preferentially or even the delta-lactam simply by adjusting the reaction parameters ([Pd], [CO], temperature).
Fontana
Francesco
F
School of Chemistry, Cantock's Close, Bristol, UK.
Tron
Gian Cesare
GC
Barbero
Nekane
N
Ferrini
Serena
S
Thomas
Stephen P
SP
Aggarwal
Varinder K
VK
D001388:Aziridines / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature; D014753:Vinyl Compounds / Q000737:chemistry*; D047090:beta-Lactams / Q000138:chemical synthesis* / Q000737:chemistry
D001388:Aziridines; D014753:Vinyl Compounds; D047090:beta-Lactams; D010165:Palladium; D002244:Carbon