title: Test-and-treat strategy for Helicobacter pylori (HP) infection in older patients.
abstract: Despite Helicobacter pylori (HP) infection is highly prevalent in older populations, low rates of HP diagnosis and eradication are reported in older persons, even in geriatric wards. We aim to evaluate the results of a HP-eradicating program in a sample of older patients in relation to dyspeptic symptoms and to endoscopic findings. A pool of 140 subjects (female/ale=86/54, mean age 68.6±5.4 years) with positive C(13)-urea breath test were recruited, clinically evaluated to investigate the presence and characteristics of dyspepsia and abdominal pain, and underwent gastric endoscopic examination. HP-eradication was obtained in 87.9% of subjects with first-line triple therapy, regardless of endoscopic findings. Sixty-eight (48.6%) patients were symptomatic and 72 (51.4%) were asymptomatic. HP-related organic disease in endoscopic examination was frequent (present in 53.6% of the patients) but the distribution of different pathologies were similar in patients with and without symptoms (p=0.86).
  
  
  CONCLUSIONS
  even if diagnosis and treatment of HP infection in older patients is underestimated, this population should be a priority for HP-eradication since the infection is more frequent, peptic disease and gastric cancer are frequent, and eradication is effective.
authors.affiliation: Geriatric Unit, Department of Internal Medicine, University of Palermo, Viale F. Scaduto 6/c, 90144 Palermo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Rotolo
authors.forename: L J
authors.initials: LJ
authors.lastname: Dominguez
authors.forename: V
authors.initials: V
authors.lastname: Sarakatsianou
authors.forename: D
authors.initials: D
authors.lastname: Mangiaracina
authors.forename: F
authors.initials: F
authors.lastname: Figlioli
authors.forename: M
authors.initials: M
authors.lastname: Barbagallo
mesh_terms: D000368:Aged; D001944:Breath Tests; D016009:Chi-Square Distribution; D004415:Dyspepsia / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D008297:Male