title: The association between Chlamydia pneumoniae and metabolic syndrome in Taiwanese adults.
abstract: OBJECTIVE
  Both Chlamydia pneumoniae (Cp) seropositivity and metabolic syndrome (MeS) have been identified as risk factors for atherosclerosis and cardiovascular disease (CVD), but the association between Cp seropositivity and MeS has not been extensively studied.
  
  
  BACKGROUND
  We recruited participants from Taiwanese adults who received an annual health examination at a medical facility. We measured anti-Cp IgG antibodies (Cp-IgG) by enzyme-linked immunosorbent assay and defined Cp-IgG seropositivity using 20 RU/mL as the cutoff point.
  
  
  RESULTS
  In the 3633 study participants, the overall Cp-IgG seropositive rate was 45.5%. Male gender, older age, white collar jobs, smoking, diabetes mellitus, and hypertension were associated with a higher Cp-IgG seropositive rate (P<0.05). Participants with MeS had a higher Cp-IgG seropositive rate (62.8% vs. 37.2%, P<0.001). Multiple logistic regression revealed that positive Cp-IgG (odds ratio [OR]=1.4, 95% confidence interval [CI]: 1.1-1.9), male gender (OR=5.0, 95% CI: 3.3-7.6) and older age(OR=2.6, 95% CI: 1.1-6.1 for age>or=40 years old) were independent predictors for MeS.
  
  
  CONCLUSIONS
  There is a positive association between Cp seropositivity and MeS, which supports the role of infection in the pathogenesis of atherosclerosis and CVD.
authors.affiliation: Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Ching-Yih
authors.initials: CY
authors.lastname: Lin
authors.forename: Shih-Bin
authors.initials: SB
authors.lastname: Su
authors.forename: Chih-Ching
authors.initials: CC
authors.lastname: Chang
authors.forename: Tsung-Ming
authors.initials: TM
authors.lastname: Lee
authors.forename: Jiunn-Min
authors.initials: JM
authors.lastname: Shieh
authors.forename: How-Ran
authors.initials: HR
authors.lastname: Guo
mesh_terms: D000328:Adult; D000367:Age Factors; D000907:Antibodies, Bacterial / Q000097:blood; D002690:Chlamydia Infections / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology; D016993:Chlamydophila pneumoniae / Q000276:immunology / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology*; D008875:Middle Aged; D016017:Odds Ratio; D018410:Pneumonia, Bacterial / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology; D018570:Risk Assessment; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G