Spectral domain optical coherence tomography for detection of foveal morphology in patients with nystagmus.
OBJECTIVE
To evaluate the feasibility of spectral domain optical coherence tomography (SD-OCT) macular scanning as a means of studying the afferent visual system in nystagmus patients.


METHODS
Nystagmus patients who underwent SD-OCT, clinical evaluation, and eye movement recordings were recruited for this prospective, single-center, noncomparative study. Three SD-OCT macular three-dimensional cube scans per eye (200 x 200 x 1024 samplings in a 6 x 6 mm region) were obtained for qualitative retinal morphology analysis.


RESULTS
Nineteen patients (6-68 years; average, 19 years) were analyzed. Of these, 17 patients had infantile nystagmus syndrome, and 2 had fusion maldevelopment nystagmus; 17 patients (89%) had associated sensory system abnormalities, including 9 (47%) with albinism. Macular images were successfully obtained in all but 1 patient (95%). Of the 8 successfully imaged oculocutaneous patients, 7 patients demonstrated "fovea plana," and all demonstrated abnormal morphology.


CONCLUSIONS
SD-OCT reliably provides detailed structural imaging of the fovea in nystagmus patients.
Cronin
Tara H
TH
The UPMC and Children's Hospital Of Pittsburgh Eye Centers and The Laboratory of Visual and Ocular Motor Physiology Pittsburgh, PA 15201, USA.
Hertle
Richard W
RW
Ishikawa
Hiroshi
H
Schuman
Joel S
JS
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005133:Eye Movements; D005240:Feasibility Studies; D005584:Fovea Centralis / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000175:diagnosis*; D011446:Prospective Studies; D041623:Tomography, Optical Coherence