title: The Association of African Ancestry and elevated creatinine in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
abstract: Whether genetic factors account for differences in early kidney disease among blacks in a young healthy population is not well known. We evaluated the association of self-reported race and genetic African ancestry with elevated creatinine (> or =1.3 mg/dl for men, > or =1.1 mg/dl for women) among 3,113 black and white participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study, ages 38-50 years. We estimated individual African ancestry using 42 ancestry informative markers. Blacks were more likely to have elevated creatinine than whites, and this effect was more pronounced in men: adjusted odds ratio (AOR) for black versus white men = 7.03, 4.15-11.91; AOR for women = 2.40, 1.15-5.02. Higher African ancestry was independently associated with elevated creatinine among black men (AOR = 1.53,1.08-2.16 per SD increase in African ancestry), but not women. A graded increase in odds of elevated creatinine by African Ancestry was observed among black men compared with white men: AOR = 4.27 (2.26-10.06) for black men with 40-70% African ancestry; AOR = 8.09 (4.19-15.61) for black men with 70-80% African ancestry; AOR = 9.05 (4.81-17.02) for black men with >80% African ancestry. Genetic factors common to African ancestry may be associated with increased risk of early kidney dysfunction in a young, healthy population, particularly among black men.
authors.affiliation: Department of Medicine, University of California San Francisco, USA. carmenalicia.peralta@ucsf.edu
authors.forename: Carmen A
authors.initials: CA
authors.lastname: Peralta
authors.forename: Neil
authors.initials: N
authors.lastname: Risch
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
authors.forename: Michael G
authors.initials: MG
authors.lastname: Shlipak
authors.forename: Alex
authors.initials: A
authors.lastname: Reiner
authors.forename: Elad
authors.initials: E
authors.lastname: Ziv
authors.forename: Hua
authors.initials: H
authors.lastname: Tang
authors.forename: David
authors.initials: D
authors.lastname: Siscovick
authors.forename: Kirsten
authors.initials: K
authors.lastname: Bibbins-Domingo
mesh_terms: D000293:Adolescent; D000328:Adult; D044383:Black People / Q000235:genetics / Q000706:statistics & numerical data*; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000208:ethnology* / Q000235:genetics; D003404:Creatinine / Q000097:blood*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D015994:Incidence; D007674:Kidney Diseases / Q000097:blood / Q000208:ethnology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D012307:Risk Factors; D017678:Sex Distribution; D044465:White People / Q000235:genetics / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D005819:Genetic Markers; D003404:Creatinine