Four projection streams from primate V1 to the cytochrome oxidase stripes of V2.
In the primate visual system, areas V1 and V2 distribute information they receive from the retina to all higher cortical areas, sorting this information into dorsal and ventral streams. Therefore, knowledge of the organization of projections between V1 and V2 is crucial to understand how the cortex processes visual information. In primates, parallel output pathways from V1 project to distinct V2 stripes. The traditional tripartite division of V1-to-V2 projections was recently replaced by a bipartite scheme, in which thin stripes receive V1 inputs from blob columns, and thick and pale stripes receive common input from interblob columns. Here, we demonstrate that thick and pale stripes, instead, receive spatially segregated V1 inputs and that the interblob is partitioned into two compartments: the middle of the interblob projecting to pale stripes and the blob/interblob border region projecting to thick stripes. Double-labeling experiments further demonstrate that V1 cells project to either thick or pale stripes, but rarely to both. We also find laminar specialization of V1 outputs, with layer 4B contributing projections mainly to thick stripes, and no projections to one set of pale stripes. These laminar differences suggest different contribution of magno, parvo, and konio inputs to each V1 output pathway. These results provide a new foundation for parallel processing models of the visual system by demonstrating four V1-to-V2 pathways: blob columns-to-thin stripes, blob/interblob border columns-to-thick stripes, interblob columns-to-pale(lateral) stripes, layer 2/3-4A interblobs-to-pale(medial) stripes.
Federer
Frederick
F
Department of Ophthalmology, University of Utah, Salt Lake City, Utah 84132, USA.
Ichida
Jennifer M
JM
Jeffs
Janelle
J
Schiessl
Ingo
I
McLoughlin
Niall
N
Angelucci
Alessandra
A
D000818:Animals; D002144:Callithrix; D003576:Electron Transport Complex IV / Q000378:metabolism*; D005260:Female; D007091:Image Processing, Computer-Assisted; D008297:Male; D008959:Models, Neurological; D009434:Neural Pathways / Q000033:anatomy & histology / Q000378:metabolism; D056325:Neuronal Tract-Tracers; D014793:Visual Cortex / Q000033:anatomy & histology* / Q000201:enzymology / Q000378:metabolism*
D056325:Neuronal Tract-Tracers; D003576:Electron Transport Complex IV