title: Infections and mast cells.
abstract: Mast cells play a role in various physiological functions: innate and acquired immunity, epithelium remodelling and proliferation, angiogenesis, cancer, inflammation and infections. Mast cells are activated by cross-linking of FcERI molecules, which are involved in the binding of multivalent antigens to the attached IgE molecules, resulting in a variety of responses including the immediate release of potent inflammatory mediators. In addition, mast cell biology consists in the capability to secrete preformed mediators which include biogenic amines and newly synthetized mediators, which include lipid-derived mediators and cytokines. It has been reported that parasite infections induce a systemic immunomodulatory network, including regulatory T cells, pro-inflammatory and anti-inflammatory cytokines, which might play a key role in the allergic phenotype. Here, in this article, we revisited the relationship between mast cells and infections.
authors.forename: P
authors.initials: P
authors.lastname: Felaco
authors.forename: E
authors.initials: E
authors.lastname: Toniato
authors.forename: M L
authors.initials: ML
authors.lastname: Castellani
authors.forename: C
authors.initials: C
authors.lastname: Ciampoli
authors.forename: D
authors.initials: D
authors.lastname: De Amicis
authors.forename: C
authors.initials: C
authors.lastname: Orso
authors.forename: C
authors.initials: C
authors.lastname: Cuccurullo
authors.forename: M A
authors.initials: MA
authors.lastname: De Lutiis
authors.forename: A
authors.initials: A
authors.lastname: Patruno
authors.forename: L
authors.initials: L
authors.lastname: Speranza
authors.forename: M
authors.initials: M
authors.lastname: Felaco
authors.forename: A
authors.initials: A
authors.lastname: Caraffa
authors.forename: F
authors.initials: F
authors.lastname: Pandolfi
authors.forename: P L
authors.initials: PL
authors.lastname: Antinolfi
authors.forename: G
authors.initials: G
authors.lastname: Cerulli
authors.forename: F
authors.initials: F
authors.lastname: Conti
authors.forename: M
authors.initials: M
authors.lastname: Fulcheri
authors.forename: G
authors.initials: G
authors.lastname: Sabatino
authors.forename: P
authors.initials: P
authors.lastname: Conti
authors.forename: Y
authors.initials: Y
authors.lastname: Shaik
mesh_terms: D000818:Animals; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology* / Q000378:metabolism; D007239:Infections / Q000276:immunology* / Q000378:metabolism / Q000469:parasitology; D018836:Inflammation Mediators / Q000276:immunology* / Q000378:metabolism; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism; D017455:Receptors, IgE / Q000276:immunology* / Q000378:metabolism
chemical_list: D018836:Inflammation Mediators; D017455:Receptors, IgE; D007073:Immunoglobulin E