Contrasting identity-by-descent estimators, association studies, and linkage analyses using the Framingham Heart Study data.
We explored the utility of population- and pedigree-based analyses using the Framingham Heart Study genome-wide 50 k single-nucleotide polymorphism marker data provided for Genetic Analysis Workshop 16. Our aims were: 1) to compare identity-by-descent sharing estimates from variable amounts of data; 2) to apply each of these estimates to a case-control association study designed to control for relatedness among samples; and 3) to contrast these results to those obtained using model-based and model-free linkage analysis methods.
Marchani
Elizabeth E
EE
Division of Medical Genetics, Department of Medicine, University of Washington, Health Sciences Building, K-253, Box 357720, Seattle, Washington 98195 USA. em27@u.washington.edu.
Di
Yanming
Y
Choi
Yoonha
Y
Cheung
Charles
C
Su
Ming
M
Boehm
Frederick
F
Thompson
Elizabeth A
EA
Wijsman
Ellen M
EM