Proteomic analysis of mitochondria in Raji cells following exposure to radiation: implications for radiotherapy response.
Radioresistance represents a major obstacle to a successful outcome for the treatment of non-Hodgkin's lymphoma (NHL). Here we performed a global differential proteome analysis of the mitochondria in Raji cells exposed to radiation. The results showed that 23 differentially expressed proteins were identified. Furthermore, GAPDH, RECQL4, MKI67, and ATAD3B could serve as potential biomarkers of radioresistance.
Jiang
Yujie
Y
Department of Hematology, Provincial Hospital Affiliated to Shandong University, Shandong, China.
Liu
Xin
X
Fang
Xiaosheng
X
Wang
Xin
X
D014408:Biomarkers, Tumor / Q000378:metabolism / Q000528:radiation effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000528:radiation effects; D019295:Computational Biology; D005434:Flow Cytometry; D015972:Gene Expression Regulation, Neoplastic / Q000528:radiation effects; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D008928:Mitochondria / Q000378:metabolism* / Q000528:radiation effects*; D020543:Proteome / Q000528:radiation effects*; D040901:Proteomics / Q000379:methods; D011878:Radiotherapy; D015203:Reproducibility of Results
D014408:Biomarkers, Tumor; D020543:Proteome