title: Miniaturized thermocontrol devices enable analysis of biomolecular behavior on their timescales, second to millisecond.
abstract: To establish general-purpose methods and tools for biological experiments on a short time scale is an essential requirement for future research in molecular biology because most of the functions of living organisms at the molecular level take place on a time scale from 1-second to millisecond. Thermal control with on-chip micro-thermodevices is one of the strongest and most useful ways to realize biological experiments at molecular level on these time scales. Novel biological phenomena revealed by the experiments using micro-thermodevices on a 1-second and millisecond time scale will be shown for the proof. Finally, the advantages and impact of this methodology in molecular biology will be discussed.
authors.affiliation: Institute of Industrial Science, The University of Tokyo, Tokyo, Japan. arata@sanken.osaka-u.ac.jp
authors.forename: Hideyuki F
authors.initials: HF
authors.lastname: Arata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujita
mesh_terms: D018929:Cell Culture Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005246:Feedback; D006361:Heating / Q000295:instrumentation*; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D008904:Miniaturization; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013696:Temperature