Analysis of North American Rheumatoid Arthritis Consortium data using a penalized logistic regression approach.
We applied a penalized regression approach to single-nucleotide polymorphisms in regions on chromosomes 1, 6, and 9 of the North American Rheumatoid Arthritis Consortium data. Results were compared with a standard single-locus association test. Overall, the penalized regression approach did not appear to offer any advantage with respect to either detection or localization of disease-associated polymorphisms, compared with the single-locus approach.
Croiseau
Pascal
P
Institute of Human Genetics, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ UK. pascal.croiseau@jouy.inra.fr.
Cordell
Heather J
HJ