title: Organocatalytic asymmetric Povarov reactions with 2- and 3-vinylindoles.
abstract: The asymmetric Povarov reaction of N-arylimines with 2- and 3-vinylindoles has been developed using a chiral phosphoric acid ((S)-TRIP) as catalyst. The peculiar reactivity of vinylindoles allowed also the disclosure of a Povarov Friedel-Crafts sequence, and the trapping of the reaction intermediate with nucleophilic species, thus providing a versatile platform for the preparation of highly enantioenriched indole derivatives.
authors.affiliation: Department of Organic Chemistry A. Mangini, University of Bologna, V. Risorgimento 4, 40136 Bologna, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Bergonzini
authors.forename: Lucia
authors.initials: L
authors.lastname: Gramigna
authors.forename: Andrea
authors.initials: A
authors.lastname: Mazzanti
authors.forename: Mariafrancesca
authors.initials: M
authors.lastname: Fochi
authors.forename: Luca
authors.initials: L
authors.lastname: Bernardi
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ricci