Synthesis and SAR of sulfonyl- and phosphoryl amidine compounds as anti-resorptive agents.
Sulfonyl amidines (1) and phosphoryl amidines (2), which were efficiently synthesized via a Cu-catalyzed one pot reaction, showed potent anti-bone resorptive activity in vitro. Structure activity relationship studies led to the identification of numerous osteoclast differentiation inhibitors.
Lee
Myung Yun
MY
Department of Chemistry and Medical Chemistry, Yonsei University, Wonju 220-710, Republic of Korea.
Kim
Myung Hee
MH
Kim
Jinho
J
Kim
Seok Hwan
SH
Kim
Bum Tae
BT
Jeong
In Howa
IH
Chang
Sukbok
S
Kim
Seong Hwan
SH
Chang
Sung-Youn
SY
D000135:Acid Phosphatase / Q000378:metabolism; D000578:Amidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D007527:Isoenzymes / Q000378:metabolism; D051379:Mice; D063065:Organophosphonates / Q000737:chemistry*; D010010:Osteoclasts / Q000187:drug effects; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000737:chemistry*; D000071681:Tartrate-Resistant Acid Phosphatase
D000578:Amidines; D007527:Isoenzymes; D063065:Organophosphonates; D013450:Sulfones; D003300:Copper; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase