Association between 22 cytokine gene polymorphisms and dilated cardiomyopathy in Macedonian patients.
BACKGROUND
Inflammation is an important component in the pathogenesis of many cardiovascular diseases and one of the commonest mechanisms in cardiomyopathy. There have been several studies on the cytokine polymorphism and dilated cardiomyopathy (DCM), but the results obtained were contradictory.


OBJECTIVE
To examine a possible role of 22 cytokine gene polymorphisms in host susceptibility to or protection against DCM in Macedonians.


METHODS
In this study 301 healthy unrelated individuals and 52 patients with DCM were studied. Cytokine genotyping was performed by PCR with sequence-specific priming (PCR-SSP) (Heidelberg kit).


RESULTS
After the Bonferroni adjustment, the IL-4 -1098/T, IL-4 -1098/T:T, IL-4/TCC, and IL-4/TCC:TTC cytokine genes were positively associated with DCM, while a negative association was identified for IL-4 -1098/G, IL-4 -1098/G:T, IL-1B +3962/C:C, IL-4/GCC, and IL-4/GCC:TTC.


CONCLUSIONS
These results suggest that some cytokine gene polymorphisms are significantly associated and affect host susceptibility/resistance to DCM in Macedonians.
Spiroska
Vera
V
Cardiology Clinic, Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia.
Kedev
Sashko
S
Antov
Slobodan
S
Trajkov
Dejan
D
Petlichkovski
Aleksandar
A
Hristomanova
Slavica
S
Djulejic
Eli
E
Paneva
Meri
M
Senev
Aleksandar
A
Spiroski
Mirko
M
D002311:Cardiomyopathy, Dilated / Q000235:genetics*; D016207:Cytokines / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006115:Greece; D006239:Haplotypes; D006801:Humans; D011110:Polymorphism, Genetic; D012016:Reference Values; D044465:White People / Q000235:genetics*
D016207:Cytokines