title: Mapping human genetic diversity in Asia.
abstract: Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.
authors.forename: Mahmood Ameen
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authors.forename: Ikhlak
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authors.lastname: Ahmed
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authors.lastname: Bhak
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authors.forename: Gayvelline C
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authors.lastname: Chaurasia
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authors.lastname: Chen
authors.forename: Jieming
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authors.lastname: Chen
authors.forename: Yuan-Tsong
authors.initials: YT
authors.lastname: Chen
authors.forename: Jiayou
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authors.lastname: Chu
authors.forename: Eva Maria C
authors.initials: EM
authors.lastname: Cutiongco-de la Paz
authors.forename: Maria Corazon A
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authors.forename: Junsong
authors.initials: J
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authors.forename: Sheng-Feng
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authors.lastname: Ho
authors.forename: Boon Peng
authors.initials: BP
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authors.forename: Wei
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authors.forename: Hidetoshi
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authors.lastname: Inoko
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authors.forename: Kwangjoong
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authors.forename: Sangsoo
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authors.forename: Kuchan
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authors.forename: Tomohiro
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authors.forename: Supasak
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authors.forename: Vikrant
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authors.lastname: Kumar
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authors.forename: Wayne
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authors.lastname: Padilla
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authors.forename: Henry B
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authors.lastname: Perdigon
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authors.forename: Yuliana
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authors.lastname: Sandraling
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authors.forename: Metawee
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authors.lastname: Srikummool
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authors.forename: Sumio
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authors.lastname: Tokunaga
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authors.forename: Lilian P
authors.initials: LP
authors.lastname: Villamor
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authors.lastname: Xiao
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authors.lastname: Xu
authors.forename: Jin Ok
authors.initials: JO
authors.lastname: Yang
authors.forename: Yin Yao
authors.initials: YY
authors.lastname: Shugart
authors.forename: Hyang-Sook
authors.initials: HS
authors.lastname: Yoo
authors.forename: Wentao
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authors.lastname: Zhao
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authors.lastname: Zilfalil
mesh_terms: D000465:Algorithms; D001208:Asia; D044466:Asian People / Q000235:genetics* / Q000266:history; D001499:Bayes Theorem; D016000:Cluster Analysis; D004641:Emigration and Immigration / Q000266:history; D005006:Ethnicity / Q000235:genetics* / Q000266:history; D051456:Gene Flow; D005838:Genotype; D005843:Geography; D006239:Haplotypes; D049690:History, Ancient; D006801:Humans; D007802:Language; D008037:Linguistics; D020411:Oligonucleotide Array Sequence Analysis; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis