title: Use of autologous bone graft in anterior cervical decompression: morbidity & quality of life analysis.
abstract: BACKGROUND
  Autologous iliac crest graft has long been the gold standard graft material used in cervical fusion. However its harvest has significant associated morbidity, including protracted postoperative pain scores at the harvest site. Thus its continued practice warrants scrutiny, particularly now that alternatives are available. Our aims were to assess incidence and nature of complications associated with iliac crest harvest when performed in the setting of Anterior Cervical Decompression (ACD). Also, to perform a comparative analysis of patient satisfaction and quality of life scores after ACD surgeries, when performed with and without iliac graft harvest.
  
  
  METHODS
  All patients who underwent consecutive ACD procedures, with and without the use of autologous iliac crest graft, over a 48 month period were included (n = 53). Patients were assessed clinically at a minimum of 12 months postoperatively and administered 2 validated quality of life questionnaires: the SF-36 and Cervical Spine Outcomes Questionnaires (Response rate 96%). Primary composite endpoints included incidence of bone graft donor site morbidity, pain scores, operative duration, and quality of life scores.
  
  
  RESULTS
  Patients who underwent iliac graft harvest experienced significant peri-operative donor site specific morbidity, including a high incidence of pain at the iliac crest (90%), iliac wound infection (7%), a jejunal perforation, and longer operative duration (285 minutes vs. 238 minutes, p = 0.026). Longer term follow-up demonstrated protracted postoperative pain at the harvest site and significantly lower mental health scores on both quality of life instruments, for those patients who underwent autologous graft harvest
  
  
  CONCLUSIONS
  ACD with iliac crest graft harvest is associated with significant iliac crest donor site morbidity and lower quality of life at greater than 12 months post operatively. This is now avoidable by using alternatives to autologous bone without compromising clinical or technical outcome.
authors.affiliation: Department of Surgery, Clinical Science Institute, National University of Ireland Galway, Galway, Ireland. helenheneghan@hotmail.com
authors.forename: Helen M
authors.initials: HM
authors.lastname: Heneghan
authors.forename: John P
authors.initials: JP
authors.lastname: McCabe
mesh_terms: D000328:Adult; D000368:Aged; D018786:Bone Substitutes / Q000592:standards; D016025:Bone Transplantation / Q000009:adverse effects* / Q000379:methods; D019299:Decompression, Surgical / Q000379:methods*; D003695:Delivery of Health Care; D005260:Female; D006801:Humans; D007085:Ilium / Q000033:anatomy & histology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010149:Postoperative Pain / Q000401:mortality; D011183:Postoperative Complications / Q000401:mortality; D011788:Quality of Life; D013117:Spinal Cord Compression / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D013123:Spinal Fusion / Q000379:methods*; D055009:Spondylosis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D013530:Surgical Wound Infection / Q000401:mortality; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes