title: InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared.
abstract: We present the synthesis of InAs quantum dots (QDs) with a ZnCdS shell with bright and stable emission in the near-infrared (NIR, 700-900 nm) region for biological imaging applications. We demonstrate how NIR QDs can image tumor vasculature in vivo at significantly deeper penetration depths and with higher contrast than visible emitting CdSe(CdS) QDs. Targeted cellular labeling is also presented and may enable multiplexed and low autofluorescence cellular imaging.
authors.affiliation: Massachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Allen
authors.forename: Wenhao
authors.initials: W
authors.lastname: Liu
authors.forename: Vikash P
authors.initials: VP
authors.lastname: Chauhan
authors.forename: Jungmin
authors.initials: J
authors.lastname: Lee
authors.forename: Alice Y
authors.initials: AY
authors.lastname: Ting
authors.forename: Dai
authors.initials: D
authors.lastname: Fukumura
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Jain
authors.forename: Moungi G
authors.initials: MG
authors.lastname: Bawendi
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007204:Indium / Q000737:chemistry*; D007259:Infrared Rays; D008670:Metals / Q000737:chemistry*; D051379:Mice; D057054:Molecular Imaging / Q000379:methods*; D045663:Quantum Dots; D012680:Sensitivity and Specificity; D015032:Zinc / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D008670:Metals; D007204:Indium; D015032:Zinc