title: Clinicopathological characteristics of primary gastric T-cell lymphoma.
abstract: OBJECTIVE
  To investigate the clinicopathological characteristics of 20 primary gastric T-cell lymphoma (GTCL) cases without human T-lymphotropic virus type I infection in Japan, a non-endemic area for coeliac disease.
  
  
  RESULTS
  Fifteen cases had no history of persistent diarrhoea or severe hypoproteinaemia. Histologically, 13 cases (65%) consisted of large cell lymphoma and seven (35%) were of medium-sized cells. Intraepithelial lymphoma cell invasion was found in three cases (15%). Two of 10 surgical cases (20%) showed intramucosal tumour cell spreading with enteropathy-like features. Helicobacter pylori CagA gene was detected in three of 10 cases (30%). The lymphoma cells of all 20 cases were positive for CD3 and/or TCRbetaF1 and negative for CD56. CD4- and CD8- lymphoma was found in 11 cases (55%), CD4+ lymphoma in seven (35%) and CD8+ lymphoma in two (10%). CD30+, CD5+ and CD25+ lymphomas were detected in nine (45%), 10 (50%) and 11 (55%) cases, respectively. Five-year survival of the 16 available cases was 54%. Early clinical stage and medium-sized cell lymphoma were significantly (P < 0.05) better prognostic factors.
  
  
  CONCLUSIONS
  Patients with GTCL exhibit distinct clinicopathological findings and prognoses from those with enteropathy-associated T-cell lymphomas. GTCL may be mainly derived from lamina propria and parafollicular T cells.
authors.affiliation: Department of Pathology, Faculty of Medicine, Fukuoka University, Nanakuma 7-15-2, Jonan-ku, Fukuoka 814-0180, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Kawamoto
authors.forename: Shotaro
authors.initials: S
authors.lastname: Nakamura
authors.forename: Akinori
authors.initials: A
authors.lastname: Iwashita
authors.forename: Jiro
authors.initials: J
authors.lastname: Watanabe
authors.forename: Yumi
authors.initials: Y
authors.lastname: Oshiro
authors.forename: Yoshifuku
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nimura
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Kimura
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Aoyagi
authors.forename: Takashi
authors.initials: T
authors.lastname: Yao
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kuramochi
authors.forename: Atsuji
authors.initials: A
authors.lastname: Matsuyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Kurihara
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Morishige
authors.initials: M
authors.lastname: Takeshita
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D019675:Genes, T-Cell Receptor gamma / Q000502:physiology; D016481:Helicobacter Infections / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017403:In Situ Hybridization; D016411:Lymphoma, T-Cell, Peripheral / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016601:RNA-Binding Proteins / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012269:Ribosomal Proteins / Q000378:metabolism; D013270:Stomach / Q000382:microbiology / Q000473:pathology*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D015703:Antigens, CD; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; C067169:RPL22 protein, human