Biocompatibility evaluation of Epiphany/Resilon root canal filling system in subcutaneous tissue of rats.
BACKGROUND
The purpose of this study was to evaluate the biocompatibility of the root canal filling system Epiphany/Resilon in connective tissue of rats.


METHODS
Fifteen rats were used, separated into 3 groups in accordance with its period of death (7, 21, 42 days). Four filled dentin tubes were implanted with the tested materials as follows: ERSP group, Epiphany/Resilon with Self-etch Primer; ER group, Epiphany/Resilon without primer; EG group, Endofill/gutta-percha points; and ET group, empty tube. After 7, 21, and 42 days, animals were killed, obtaining 5 samples per group. A grade from I-IV was used to graduate the inflammatory reaction.


RESULTS
Results showed that Epiphany/Resilon (ERSP and ER groups) induced a slight (II) inflammatory reaction after 42 days. However, in ER group, in which the self-etch primer was not applied, severe (IV) to moderate (III) inflammatory reactions were observed between 7 and 21 days. When compared with the EG and ET groups, it was observed that these groups presented tissue reaction ranging from slight (II, 7 and 21 days) to no inflammation (I, 42 days).


CONCLUSIONS
Epiphany/Resilon root canal filling system presented satisfactory tissue reaction. It was biocompatible when tested in connective tissue of rats.
Garcia
Lucas da Fonseca Roberti
Lda F
Department of Restorative Dentistry, Dental Materials Area, Piracicaba School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil.
Marques
André Augusto Franco
AA
Roselino
Lourenço de Moraes Rego
Lde M
Pires-de-Souza
Fernanda de Carvalho Panzeri
Fde C
Consani
Simonides
S
D000818:Animals; D001672:Biocompatible Materials; D045662:Dental Etching; D008297:Male; D008422:Materials Testing; D051381:Rats; D012387:Root Canal Filling Materials / Q000633:toxicity*; D040521:Subcutaneous Tissue / Q000187:drug effects*
D001672:Biocompatible Materials; D012387:Root Canal Filling Materials; C486893:epiphany sealer; C486892:resilon sealer