title: [A case of congenital hepatic fibrosis presented with recurrent acute cholangitis].
abstract: Acute cholangitis usually develops in congenital hepatic fibrosis (CHF), accompanied by cystic dilated bile ducts. However, it can also develop in simple CHF and may lead to critical course. A 30-year old man presented with recurrent acute cholangitis without bile duct dilatation. He visited the hospital for febrile sense and abdominal pain in the right upper quadrant. He had been admitted several times for hepatosplenomegaly and cholangitis since childhood and received a liver biopsy 15 years ago. Abdominal computed tomography (CT) and endoscopic retrograde cholangiopancreatography (ERCP) revealed hepatosplenomegaly and a mildly dilated bile duct without stones or biliary cysts. His condition improved after conservative treatment. However, during a two-month follow up period, the patient experienced three episodes of acute cholangitis. A liver biopsy was performed and showed periportal fibrosis and intrahepatic ductular dysplasia, characteristics of congenital hepatic fibrosis. The periportal fibrosis and the infiltration of inflammatory cells were aggravated compared to 15 years ago. There was no evidence of hepatic cirrhosis. He was diagnosed with congenital hepatic fibrosis with recurrent acute cholangitis without intrahepatic duct dilatation, and conservatively treated with antibiotics.
authors.affiliation: Department of Internal Medicine, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Korea.
authors.forename: Shin Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Joo
authors.forename: Young Shim
authors.initials: YS
authors.lastname: Cho
authors.forename: Won Joong
authors.initials: WJ
authors.lastname: Jeon
authors.forename: Hee Bok
authors.initials: HB
authors.lastname: Chae
authors.forename: Seon Mee
authors.initials: SM
authors.lastname: Park
authors.forename: Sei Jin
authors.initials: SJ
authors.lastname: Youn
authors.forename: Rohyun
authors.initials: R
authors.lastname: Sung
mesh_terms: D000208:Acute Disease; D000328:Adult; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002761:Cholangitis / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000151:congenital* / Q000473:pathology; D008297:Male; D012008:Recurrence; D014057:Tomography, X-Ray Computed