title: [Tracheobronchomalacia].
abstract: Tracheobronchomalacia is a central airway disease characterised by weakness of the wall and dynamic decrease in the tracheal lumen and the large bronchi, particularly while exhaling. It is more common in middle age and the elderly with previous exposure to cigarettes. It causes chronic symptoms such as cough, dyspnea, increase in recurrent infections, and poor secretion management, but it can also progress to chronic respiratory failure and death. It is usually confused with other common diseases like chronic obstructive pulmonary disease (COPD) or asthma. Its causes can be congenital or acquired and its diagnosis involves the dynamic assessment of the airway with tomography and fibrobronchoscopy. It is classified as mild, moderate or severe depending on the degree of collapse of the airway when exhaling. Management consists of a primary phase, in which concomitant diseases must be controlled, such as COPD, asthma or gastro-oesophageal reflux. In diffuse moderate to severe symptomatic tracheobronchomalacia tracheobronchoplasty must be considered with strengthening of the posterior wall. Silicone and "Y" stents can be used to identify patients who could potentially benefit from surgical treatment as well as being used for the definitive symptomatic treatment with high surgical risk. More prospective studies need to be done in order to standardise certain common criteria for the management of this usually under-diagnosed disease.
authors.affiliation: División de Neumología Intervencionista, Beth Israel Deaconess Medical Center, Boston, MA, USA. amajid@bidmc.harvard.edu
authors.forename: Adnan
authors.initials: A
authors.lastname: Majid
authors.forename: Liliana
authors.initials: L
authors.lastname: Fernández
authors.forename: Sebastián
authors.initials: S
authors.lastname: Fernández-Bussy
authors.forename: Felix
authors.initials: F
authors.lastname: Herth
authors.forename: Armin
authors.initials: A
authors.lastname: Ernst
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001993:Bronchodilator Agents / Q000627:therapeutic use; D055091:Bronchomalacia / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D045422:Continuous Positive Airway Pressure; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis; D012129:Respiratory Function Tests; D012720:Severity of Illness Index; D015607:Stents; D055090:Tracheomalacia / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy
chemical_list: D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents