title: Biochemical evaluation of the therapeutic effectiveness of honey in oral mucosal ulcers.
abstract: The aim of this study was to describe and quantify the therapeutic value of honey in oral mucosal ulcers healing in comparison with Glyceroloxytriester (TGO). We also aimed to biochemically evaluate the healing effects of honey which had been collected from the Blacksea region flora on mucosal ulcers resulting in material loss.Thirty wistar rats (240+/-30 g) were enrolled in this study. Excisional wounds were performed in all rats for animal oral mucosal ulcer model. They were randomly allocated to three groups: group 1 was treated with Apitherapeutic agent or honey (0,1 ml, 2x1), group 2 was treated with TGO (0,1ml, 2x1) locally, Group 3 served as the control group.Following the surgical procedure on day 7, biopsy specimens were taken from right buccal mucosa and on day 14 biopsy specimens were taken from left bucal mucosa in all rats. Afterwards, hydroxy pyroline levels were measured. Data were analyzed statistically.There was no statistically significant difference between Group 1 and 2, and also between Group 2 and 3, but there was statistically significant difference between Group 1 and 3 on day 7. There was no statistically significant difference between Group 1, 2 and 3 on day 14.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Dental Faculty, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Nergiz
authors.initials: N
authors.lastname: Yilmaz
authors.forename: Ozlem
authors.initials: O
authors.lastname: Nisbet
authors.forename: Cevat
authors.initials: C
authors.lastname: Nisbet
authors.forename: Gözlem
authors.initials: G
authors.lastname: Ceylan
authors.forename: Fatih
authors.initials: F
authors.lastname: Hoşgör
authors.forename: O Doğu
authors.initials: OD
authors.lastname: Dede
mesh_terms: D000818:Animals; D001706:Biopsy; D004195:Disease Models, Animal; D004952:Esters / Q000627:therapeutic use; D005990:Glycerol / Q000627:therapeutic use; D006722:Honey; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology*; D019226:Oral Ulcer / Q000188:drug therapy* / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D004952:Esters; D005990:Glycerol