BRCA1 and its toolbox for the maintenance of genome integrity.
The breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression function primarily through its involvement in cell cycle checkpoint control and DNA damage repair. In addition, recent proteomic and genetic studies have revealed the presence of distinct BRCA1 complexes in vivo, each of which governs a specific cellular response to DNA damage. Thus, BRCA1 is emerging as the master regulator of the genome through its ability to execute and coordinate various aspects of the DNA damage response.
Huen
Michael S Y
MS
Department of Anatomy, The University of Hong Kong, Laboratory Block, 21 Sassoon Road, Hong Kong.
Sy
Shirley M H
SM
Chen
Junjie
J
D000818:Animals; D019313:BRCA1 Protein / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle; D004249:DNA Damage; D004260:DNA Repair; D042822:Genomic Instability; D006801:Humans
D019313:BRCA1 Protein