[Evaluation of the immunoregulatory activity of neutrophilokine fractions in a macrophage model].
A procedure was proposed to evaluate the immunoregulatory activity of neutrophilokine fractions on a model of macrophages. It was established that all the fractions studied did not affect the absorptive capacity of these cells in both primary and secondary immune responses. At the same time, the majority of neutrophilokine fractions modulated the killer activity of macrophages: they potentiated or inhibited it. The proposed procedure for evaluating the regulatory effect of individual neutrophilokine fractions on a model of studying the killer activity makes it possible not only to characterize their activity, but also to identify helper and suppressor fractions, which discloses approaches to correcting an immune response by means of these fractions.
Ivanova
I A
IA
Vasil'eva
G I
GI
Bespalova
I A
IA
Omel'chenko
N D
ND
Kiseleva
A K
AK
Doroshenko
E P
EP
D000818:Animals; D055612:Cytokine-Induced Killer Cells / Q000276:immunology; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D008262:Macrophage Activation; D017737:Macrophages, Peritoneal / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism; D010587:Phagocytosis; D010931:Plague Vaccine / Q000276:immunology; D015010:Yersinia pestis / Q000276:immunology
D016207:Cytokines; D010931:Plague Vaccine