title: Inherited dyslipidaemic disorders contributing to coronary heart disease.
abstract: BACKGROUND
  Lipoprotein (a) [Lp (a)] is an established independent risk factor for premature myocardial infarction (MI)/coronary artery disease (CAD). The study was conducted to determine the value of Lp (a) in prediction of CAD or MI in the offspring at risk.
  
  
  METHODS
  A total of 160 subjects were investigated. Serum Lp (a) was measured by ELISA, serum total cholesterol, triglycerides (TG) and HDL-Cholesterol by enzymatic colorimetric methods using standard kits.
  
  
  RESULTS
  Differences in levels of total Lp (a) and cholesterol were observed between patients and controls. Both Lp (a) (16.23 +/-1.95 mg/dL) and cholesterol (175.00 +/- 7.60 mg/dL) of group A (patients) were higher than the corresponding controls. However an opposite trend in results was noted for serum HDL-Cholesterol in patients vs. controls.
  
  
  CONCLUSIONS
  Persons found to have elevated levels of Lp (a) should focus on controlling the known modifiable risk factor for heart disease, especially smoking, hypercholesterolemia, obesity, hypertension and sedentary life style.
authors.affiliation: Department of Chemical Pathology, Hayatabad Medical Complex, Peshawar, Pakistan.
authors.forename: Salma
authors.initials: S
authors.lastname: Attaullah
authors.forename: Rahim
authors.initials: R
authors.lastname: Bangash
authors.lastname: Amanullah
authors.forename: Zahoor
authors.initials: Z
authors.lastname: Ahmed
authors.forename: Jamilur
authors.initials: J
authors.lastname: Rehman
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood / Q000235:genetics; D003324:Coronary Artery Disease / Q000097:blood / Q000235:genetics*; D050171:Dyslipidemias / Q000097:blood / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010375:Pedigree
chemical_list: D017270:Lipoprotein(a); D002784:Cholesterol