Practical one-pot two-step protocol for the microwave-assisted synthesis of highly functionalized rhodanine derivatives.
A fast and efficient protocol for the generation of substituted 5-arylidene rhodanines in a sequential one-pot two-step process combining the "Holmberg method" and the Knoevenagel condensation under microwave-assisted conditions has been developed. The final compounds 11a-k have been obtained in high yield and purity after a simple precipitation from methanol, making this procedure facile, practical, and rapid to execute.
Radi
Marco
M
Dipartimento Farmaco Chimico Tecnologico, University of Siena, Siena, Italy.
Botta
Lorenzo
L
Casaluce
Gianni
G
Bernardini
Martina
M
Botta
Maurizio
M
D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D015394:Molecular Structure; D012236:Rhodanine / Q000737:chemistry*; D013997:Time Factors
D012236:Rhodanine