title: Relapse to drug seeking following prolonged abstinence: the role of environmental stimuli.
abstract: Successful treatment of drug addiction must involve relapse prevention informed by our understanding of the neurobiological bases of drug relapse. In humans, exposure to drug-associated environmental stimuli can elicit drug craving and relapse. Because exposure to drug-paired stimuli similarly induces drug-seeking behavior in laboratory animals, several animal models of drug relapse have been developed. Here, we review animal models of cue-induced drug relapse and critically evaluate their validity and utility in addressing human relapse behaviors.
authors.affiliation: Department of Psychology, University of North Carolina, NC 27599-3270.
authors.forename: R A
authors.initials: RA
authors.lastname: Fuchs
authors.forename: H C
authors.initials: HC
authors.lastname: Lasseter
authors.forename: D R
authors.initials: DR
authors.lastname: Ramirez
authors.forename: X
authors.initials: X
authors.lastname: Xie