title: Clinicopathologic similarities between Mikulicz disease and Küttner tumor.
abstract: OBJECTIVE
  Recent studies have revealed that Mikulicz disease (MD) differs from Sjögren syndrome and is an immunoglobulin G(4) (IgG(4))-related systemic disease. Küttner tumor (KT) is also reported to be an IgG(4)-related disease. In this study, we examined the clinicopathologic and serologic findings in MD (39 patients) and KT (6 patients) and attempted to discern the similarities between MD and KT.
  
  
  METHODS
  We diagnosed 39 patients with MD and 6 patients with KT. We analyzed the clinicopathologic and serologic findings (IgG subclasses) in 39 patients with MD and 6 patients with KT. Submandibular and labial salivary gland specimens obtained from patients with MD and KT were stained with anti-IgG(4) antibodies.
  
  
  RESULTS
  The mean IgG(4) concentration (±SD) was 931.1 ± 796.2 mg/dL in patients with MD and 756.2 ± 449.2 mg/dL in patients with KT. Abundant infiltration of IgG(4)-positive plasmacytes into the salivary glands was observed in both patients with MD and patients with KT.
  
  
  CONCLUSIONS
  The serologic and histopathologic findings in MD and KT are very similar, and these 2 conditions may be IgG(4)-related systemic diseases.
authors.affiliation: Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan. k-takano@v7.com
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Takano
authors.forename: Motohisa
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Shinomura
authors.forename: Kohzoh
authors.initials: K
authors.lastname: Imai
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Himi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D008882:Mikulicz' Disease / Q000276:immunology* / Q000473:pathology*; D010950:Plasma Cells / Q000276:immunology; D012469:Salivary Glands / Q000276:immunology; D012793:Sialadenitis / Q000276:immunology* / Q000473:pathology*; D013363:Submandibular Gland / Q000276:immunology; D013364:Submandibular Gland Diseases / Q000276:immunology* / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G