[(13)C]Methionine breath test as a marker for hepatic mitochondrial function in HIV-infected patients.
Metabolic disturbances such as dyslipidemia, lipodystrophy syndrome, visceral obesity, hyperlactatemia, diabetes mellitus, and hepatic steatosis have been recognized as serious complications in long-term antiretroviral-treated HIV-infected patients. The oxidative capacity of liver mitochondria plays a central role in their pathogenesis and can be analyzed using the [(13)C]methionine breath test. We analyzed hepatic mitochondrial function using the [(13)C]methionine breath test in antiretrovirally treated and untreated HIV-infected patients as well as HIV-negative controls. Patients with hepatic steatosis, hypertriglyceridemia, lipohypertrophy, and older age showed reduced methionine metabolism. Hepatic mitochondrial function is impaired in antiretroviral-treated HIV-infected patients with disturbances of lipid metabolism.
Sternfeld
T
T
II. Medizinische Klinik und Poliklinik, Infektionsambulanz, Klinikum rechts der Isar, Technische Universität München, Munich, Germany. thomas.sternfeld@web.de
Lorenz
A
A
Schmid
M
M
Schlamp
A
A
Demmelmair
H
H
Koletzko
B
B
Bogner
J R
JR
D000328:Adult; D000367:Age Factors; D001944:Breath Tests / Q000379:methods*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000378:metabolism / Q000821:virology; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D008107:Liver Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000821:virology; D008297:Male; D008715:Methionine / Q000378:metabolism*; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000378:metabolism* / Q000473:pathology; D015999:Multivariate Analysis; D015203:Reproducibility of Results
D008715:Methionine