title: Subdural fluid collections in patients with infantile neuronal ceroid lipofuscinosis.
abstract: OBJECTIVE
  To describe subdural fluid collections on magnetic resonance imaging as part of the natural history of infantile neuronal ceroid lipofuscinosis.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Program on Developmental Endocrinology and Genetics, The Clinical Center, National Institutes of Health, Bethesda, Maryland.
  
  
  METHODS
  Patients with infantile neuronal ceroid lipofuscinosis with subdural fluid collections.
  
  
  METHODS
  Neurodegeneration on magnetic resonance imaging.
  
  
  RESULTS
  During an ongoing bench-to-bedside clinical investigation, magnetic resonance imaging examinations led to the incidental discovery of subdural fluid collections in 4 of 9 patients with infantile neuronal ceroid lipofuscinosis. No particular event (such as trauma) or change in symptoms was linked to this finding, which was already in the chronic phase when discovered. Of the 4 patients, 1 was followed up for 7 years, 2 for 4 years, and 1 for 2.5 years. Over time, these collections remained stable or decreased in size.
  
  
  CONCLUSIONS
  Recognition that subdural fluid collections are part of the infantile neuronal ceroid lipofuscinosis disease process may obviate the necessity of additional workup as well as therapeutic interventions in these chronically sick children.
authors.affiliation: Department of Pediatrics,Walter Reed Army Medical Center, Washington, DC, USA.
authors.forename: Sondra W
authors.initials: SW
authors.lastname: Levin
authors.forename: Eva H
authors.initials: EH
authors.lastname: Baker
authors.forename: Andrea
authors.initials: A
authors.lastname: Gropman
authors.forename: Zenaide
authors.initials: Z
authors.lastname: Quezado
authors.forename: Ning
authors.initials: N
authors.lastname: Miao
authors.forename: Zhongjian
authors.initials: Z
authors.lastname: Zhang
authors.forename: Alice
authors.initials: A
authors.lastname: Jollands
authors.forename: Matteo
authors.initials: M
authors.lastname: Di Capua
authors.forename: Rafael
authors.initials: R
authors.lastname: Caruso
authors.forename: Anil B
authors.initials: AB
authors.lastname: Mukherjee
mesh_terms: D002648:Child; D006801:Humans; D009472:Neuronal Ceroid-Lipofuscinoses / Q000150:complications* / Q000175:diagnosis*; D013353:Subdural Effusion / Q000150:complications* / Q000175:diagnosis*; D013355:Subdural Space / Q000473:pathology