title: S-100beta and neuron-specific enolase levels in carbon monoxide-related brain injury.
abstract: BACKGROUND
  Carbon monoxide (CO) toxicity may cause persistent injuries in tissues sensitive to hypoxia. Neuropsychiatric sequelae may be observed in about 67% of cases after severe CO exposure.
  
  
  OBJECTIVE
  The aims of this study were to demonstrate the usefulness of S-100beta and neuron-specific enolase (NSE) in CO intoxications, show the degree of neurological response, and determine the indications for hyperbaric oxygen treatment (HBOT) as biochemical markers.
  
  
  RESULTS
  The S-100beta and NSE levels of the sera of 30 patients were studied upon admittance and at the third and sixth hours. S-100beta levels were found to be high in all 3 analyses. There was no significant change in NSE levels. When the S-100beta levels were compared with Glasgow Coma Scale levels, a strong negative correlation was found for all hours (r = -0.7, -0.8; P = .00). The correlation between S-100beta and carboxyhemoglobin levels at the initial hour was found to be statistically significant (r = 0.4; P = .01). The S-100beta levels in patients receiving HBOT showed a considerable decrease compared with those in patients not receiving the treatment. The same decrease was valid for NSE, although it was insignificant.
  
  
  CONCLUSIONS
  S-100beta may be useful in evaluating intoxications as an early biochemical marker in CO intoxications, as well as in the differential diagnosis due to other causes, and in determining HBOT indications.
authors.affiliation: Department of Emergency Medicine, Ataturk University, Medical School, 25090 Erzurum, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Cakir
authors.forename: Sahin
authors.initials: S
authors.lastname: Aslan
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Umudum
authors.forename: Hamit
authors.initials: H
authors.lastname: Acemoglu
authors.forename: Ayhan
authors.initials: A
authors.lastname: Akoz
authors.forename: Sule
authors.initials: S
authors.lastname: Turkyilmaz
authors.forename: Nurinnisa
authors.initials: N
authors.lastname: Oztürk
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001927:Brain Diseases / Q000097:blood* / Q000209:etiology; D002249:Carbon Monoxide Poisoning / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D009414:Nerve Growth Factors / Q000097:blood*; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase