[Helicobacter pylori virulence factors except CagA].
Study for Helicobacter pylori pathogenesis has been already performed widely all over the world for about 20 years. This review summarized recent studies about virulence factors except CagA/cag PAI system. Bacterial adhesion to gastric mucosa is critical for the persistent infection and BabA, SabA, OipA, AlpA or AlpB is involved. VacA (vacuolating cytotoxin) causes not only vacuolation of gastric epithelial cells but also stimulates apoptosis via a mitochondria-dependent pathway and is a potent immunomodulatory toxins. Signaling pathway via toll-like receptors(TLR) is also thought to be important especially in myeloid cells even though bioactivity of H. pylori LPS is reported to be weak compared with other bacteria such as E. coli.
Maeda
Shin
S
Department of Gastroenterology, University of Tokyo.
D000818:Animals; D017209:Apoptosis; D001422:Bacterial Adhesion; D016481:Helicobacter Infections / Q000209:etiology; D016480:Helicobacter pylori; D006801:Humans; D015398:Signal Transduction; D037521:Virulence Factors
D037521:Virulence Factors