Mild cognitive impairment: ten years later.
In the past 10 years, there has been a virtual explosion in the literature concerning the construct of mild cognitive impairment. The interest in this topic demonstrates the increasing emphasis on the identification of the earliest features of cognitive disorders such as Alzheimer disease and other dementias. Mild cognitive impairment represents the earliest clinical features of these conditions and, hence, has become a focus of clinical, epidemiologic, neuroimaging, biomarker, neuropathological, disease mechanism, and clinical trials research. This review summarizes the progress that has been made while also recognizing the challenges that remain.
Petersen
Ronald C
RC
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. peter8@mayo.edu
Roberts
Rosebud O
RO
Knopman
David S
DS
Boeve
Bradley F
BF
Geda
Yonas E
YE
Ivnik
Robert J
RJ
Smith
Glenn E
GE
Jack
Clifford R
CR
D000544:Alzheimer Disease / Q000175:diagnosis / Q000378:metabolism / Q000523:psychology; D002986:Clinical Trials as Topic / Q000639:trends; D003072:Cognition Disorders / Q000175:diagnosis* / Q000378:metabolism / Q000523:psychology*; D006801:Humans