title: Intravascular lymphocytosis in acute appendicitis: potential mimicry of chronic lymphocytic leukaemia.
abstract: OBJECTIVE
  Intravascular lymphocytosis (IVL) in appendectomy specimens is a fairly common phenomenon but has not been described and studied in detail. The aim was to describe the IVL phenomenon in appendiceal specimens removed for appendicitis that can mimic chronic lymphocytic leukaemia and to investigate factors that could contribute to the development of IVL.
  
  
  RESULTS
  The clinicopathology of 100 appendectomy cases and the appendices from 20 right hemicolectomy cases were reviewed. The IVL phenomenon was more commonly seen in laparoscopic appendectomy specimens [Fisher's exact 0.011, odds ratio (OR) 3.14] and in patients <38 years old (Fisher's exact 0.012, OR 3.01).
  
  
  CONCLUSIONS
  Surgical manipulation and the patient's innate immunity are contributary factors to the development of the IVL phenomenon. Pathologists should be aware of this histological artefact in order to prevent overdiagnosis of intravascular lymphoid neoplasia.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, AB, Canada.
authors.forename: Sandra
authors.initials: S
authors.lastname: Lee
authors.forename: Robert T
authors.initials: RT
authors.lastname: Ogilvie
authors.forename: Marc
authors.initials: M
authors.lastname: Dupre
authors.forename: Zu-Hua
authors.initials: ZH
authors.lastname: Gao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism; D001062:Appendectomy; D001064:Appendicitis / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D001065:Appendix / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis*; D008218:Lymphocytosis / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D008499:Medical Records; D008875:Middle Aged
chemical_list: D015703:Antigens, CD