Hemoglobin levels predict exercise performance, ST-segment depression, and outcome in patients referred for routine exercise treadmill testing.
BACKGROUND
While the role of hemoglobin in heart failure and renal disease has been investigated, little is known about its effect on clinical exercise test performance and mortality in patients referred for routine exercise treadmill testing (ETT).


OBJECTIVE
Patients with low hemoglobin will have poor exercise capacity and would be at increased risk of mortality and cardiovascular (CV) events.


METHODS
Clinical variables, laboratory values, and exercise treadmill data were obtained for 1,799 patients referred for routine ETT from 1997 to 2004. All-cause mortality was obtained from the United States Social Security death index and autopsy reports or clinical notes were used to determine CV events and mortality. P values < 0.05 were considered significant.


RESULTS
Our population had a mean age of 58 +/- 12 years, 16% had diabetes, 53% had hypertension, 35% had hypercholesterolemia, and 67% had a history of smoking. During follow-up, 10.3% of patients died, 3.9% of patients died of CV causes, and 11.6% had cardiovascular events. Anemic patients (hemoglobin [Hgb] < 13 g/dL) achieved lower metabolic equivalents (METs) than nonanemic patients and had more ST-segment depression (15.5% versus 8.6%, p < 0.004). Proportional hazard analysis demonstrated that hemoglobin was significantly associated with all-cause mortality (p < 0.0007), CV mortality (p < 0.009), and CV events (p < 0.01). Kaplan-Meier survival analysis demonstrated that anemic patients had significantly higher mortality and CV events.


CONCLUSIONS
Hemoglobin is significantly associated with exercise performance, ST-segment depression during ETT, mortality, and cardiovascular events. The incorporation of hemoglobin may add diagnostic and prognostic information to ETT.
Lipinski
Michael J
MJ
Veterans Affairs Palo Alto Health Care System, Stanford University Administration Health Care System, Palo Alto, California, USA.
Dewey
Frederick E
FE
Biondi-Zoccai
Giuseppe G
GG
Abbate
Antonio
A
Vetrovec
George W
GW
Froelicher
Victor F
VF
D000367:Age Factors; D000740:Anemia / Q000453:epidemiology; D015992:Body Mass Index; D002316:Cardiotonic Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000453:epidemiology; D004562:Electrocardiography; D005080:Exercise Test; D017079:Exercise Tolerance; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007674:Kidney Diseases / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D014481:United States / Q000453:epidemiology
D002316:Cardiotonic Agents; D006454:Hemoglobins