Molecular evidence of persistent epidemic and evolution of subgenotype B1 coxsackievirus A16-associated hand, foot, and mouth disease in China.
The molecular epidemiology of CVA16 in China between 1999 and 2008 reflects a pattern of endemic cocirculation of clusters B1a and B1b within subgenotype B1 viruses. The annual evolution rate of CVA16 was estimated as approximately 0.91 x 10(-2) substitutions per synonymous nucleotide/year and is slightly lower than that of HEV71.
Zhang
Yong
Y
WHO WPRO Regional Polio Reference Laboratory, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, No. 27, Nanwei Road, Xuanwu District, Beijing 100050, People's Republic of China.
Wang
Dongyan
D
Yan
Dongmei
D
Zhu
Shuangli
S
Liu
Jianfeng
J
Wang
Haiyan
H
Zhao
Shengcang
S
Yu
Deshan
D
Nan
Lijuan
L
An
Junjing
J
Chen
Li
L
An
Hongqiu
H
Xu
Aiqiang
A
Xu
Wenbo
W
D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D019353:Endemic Diseases; D029821:Enterovirus A, Human / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D019143:Evolution, Molecular; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D017354:Point Mutation; D011110:Polymorphism, Genetic; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
D012367:RNA, Viral