title: Diagnostic value of nasal allergen challenge combined with radiography and ultrasonography in chronic maxillary sinus disease.
abstract: OBJECTIVE
  To investigate the possible role of nasal allergy in chronic disease of the maxillary sinuses (CDMS) by means of nasal provocation test (NPT) with allergen combined with radiography and ultrasonography.
  
  
  METHODS
  Prospective clinical controlled study.
  
  
  METHODS
  Academic referral center.
  
  
  METHODS
  Seventy-one patients with CDMS and 16 control subjects with allergic rhinitis but no history of sinus disease.
  
  
  METHODS
  In the 71 patients, a total of 135 NPTs and 71 control challenges with phosphate-buffered saline were performed by rhinomanometry combined with radiography and ultrasonography. In the control patients, 16 positive NPTs were repeated and combined with radiography and ultrasonography.
  
  
  METHODS
  Number, type, and timing of nasal responses with accompanying changes on radiographs and ultrasonograms.
  
  
  RESULTS
  Of the 71 patients, 67 developed 104 positive nasal responses of various types (P < .001), 89 of which were accompanied by significant changes on radiographs (P = .008), whereas 83 were also associated with significant changes on ultrasonograms (P = .007). No significant changes on the radiographs or the ultrasonograms were recorded during the 71 phosphate-buffered saline control tests in the patients with CDMS (P = .14 and .06, respectively) or during the 16 NPTs in control subjects (P = .15 and .12, respectively). The radiographic and ultrasonographic findings were significantly correlated (r = 0.81; P < .01).
  
  
  CONCLUSIONS
  Nasal allergy may be involved in some patients with CDMS, resulting in appearance of a maxillary sinus response. Monitoring this response by means of serial ultrasonography and, if necessary, also by conventional radiography or computed tomography simultaneously with the nasal challenge with allergen seems to be a very useful diagnostic supplement allowing additional therapeutic measures focused on the nasal allergy.
authors.affiliation: Allergy Research Foundation, Effenseweg 42, Breda, the Netherlands. zpelikan@casema.nl
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Pelikan
mesh_terms: D000328:Adult; D000485:Allergens; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008443:Maxillary Sinus / Q000000981:diagnostic imaging; D009299:Nasal Provocation Tests; D009668:Nose Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D010254:Paranasal Sinus Diseases / Q000150:complications*; D011859:Radiography; D012130:Respiratory Hypersensitivity / Q000175:diagnosis* / Q000000981:diagnostic imaging; D012882:Skin Tests; D014463:Ultrasonography
chemical_list: D000485:Allergens