[Diethylnitrosamine-induced carcinogenesis in PARP-1(-/-) and PARP-1(+/+) mice].
Our study is concerned with comparative analysis of diethylnitrosamine (DENA)-induced carcinogenesis in PARP-1 knock-out female mice PARP-1(-/-) and wild type animals PARP-1(+/+). No difference was recorded in relation to total tumor incidence (88 and 95%, respectively): cardia (87 and 84%, respectively), liver (80 and 66%, respectively). However, experimental animals PARP-1(-/-) tended to reveal incidence of cardia tumors with invasion as deep as the serosa higher than in PARP-1(+/+) mice (100 and 81%, respectively) and metastases to the liver and lung--27 and 7%, respectively. Relative incidence of angiosarcoma and holangiocarcinoma among liver tumors from PARP-1(-/-) mice was higher than that in wild type mice. Hence DENA induced the most aggressive tumors in PARP-1(-/-) knockout mice more often than in PARP-1(+/+) ones. Our results confirm the significance of the role of DNA repair in carcinogenesis.
Piskunova
T S
TS
Zabezhinskiĭ
M A
MA
Popovich
I G
IG
Tyndyk
M L
ML
Iurova
M N
MN
Anisimov
V N
VN
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D018281:Cholangiocarcinoma / Q000139:chemically induced; D004260:DNA Repair; D004052:Diethylnitrosamine / Q000633:toxicity*; D005260:Female; D006394:Hemangiosarcoma / Q000139:chemically induced; D015994:Incidence; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D051379:Mice; D018345:Mice, Knockout; D009361:Neoplasm Invasiveness; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000235:genetics; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics*; D013274:Stomach Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D004052:Diethylnitrosamine; D011065:Poly(ADP-ribose) Polymerases