title: Perioperative monitoring of thromboelastograph on hemostasis and therapy for cyanotic infants undergoing complex cardiac surgery.
abstract: This study investigated features and treatments of perioperative coagulopathies in cyanotic infants with complex congenital heart disease (CCHD). Thirty-six infants with cyanotic CCHD were involved and divided into two groups: In group H (n = 20), hematocrit (HCT) > 54%, and in group L (n = 16), HCT < 54%. Blood was sampled at anesthesia induction (T1), rewarming to 36 degrees C (T2), after heparin neutralization (T3), and 4 h after operation (T4). The hemostatic changes were evaluated by thromboelastograph (TEG). After surgery, group H was treated with fibrinogen-combined platelets (PLT), while group L was treated with PLT only. We observed the effect at T4. At T1, the hemostatic function in group H, deteriorating with the increase of HCT (P < 0.01), was obviously lower than that in group L (P < 0.01), but the PLT function was still complete. In group H, the hemostatic function at T2 decreased with a significant drop of PLT function (P < 0.01) and had little change of functional fibrinogen (Ffg) (P > 0.05). At T3, compared with T2, there were improvements in hemostatic function and Ffg (P < 0.01, respectively) without increase of PLT (P > 0.05) in group H. After therapy, PLT function in both groups restored to T1 level (P > 0.05); Ffg at T4 was significantly better than at T1 (P < 0.01) in group H, but Ffg at T4 with still normal function was lower than at T1 in group L (P < 0.01). Whole hemostatic function at T4 was back to normal and had no differences between two groups. So, we proposed that fibrinogen and PLT transfusion in combination should be better for infants with high HCT CCHD, but PLT alone might be enough for low HCT ones.
authors.affiliation: Department of Cardiopulmonary Bypass, Cardiovascular Institute and Fuwai Hospital, CAMS and PUMS, Beijing, China.
authors.forename: Yongli
authors.initials: Y
authors.lastname: Cui
authors.forename: Feilong
authors.initials: F
authors.lastname: Hei
authors.forename: Cun
authors.initials: C
authors.lastname: Long
authors.forename: Zhengyi
authors.initials: Z
authors.lastname: Feng
authors.forename: Ju
authors.initials: J
authors.lastname: Zhao
authors.forename: Fuxia
authors.initials: F
authors.lastname: Yan
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Wang
authors.forename: Jinping
authors.initials: J
authors.lastname: Liu
mesh_terms: D002315:Cardiopulmonary Bypass; D002675:Child, Preschool; D003490:Cyanosis / Q000601:surgery* / Q000628:therapy*; D005340:Fibrinogen / Q000627:therapeutic use*; D006330:Heart Defects, Congenital / Q000601:surgery* / Q000628:therapy*; D006400:Hematocrit; D006487:Hemostasis; D006801:Humans; D007223:Infant; D017713:Platelet Transfusion; D013916:Thrombelastography
chemical_list: D005340:Fibrinogen