Developmental changes of the contingent negative variation in migraine and healthy children.
It has been hypothesized that abnormalities of information processing in migraine may be attributed to impairment of cerebral maturation. However, the most evidences for this hypothesis have come from cross-sectional studies during childhood. We performed a longitudinal study and recorded contingent negative variation (CNV), an event-related slow cortical potential, in migraine children (n = 27) and age-matched healthy individuals (n = 23) in 1998 and 8 years later (2006). Amplitudes of all CNV components were reduced and habituation of the initial CNV (iCNV) increased in the observed time. However, the reduction of the iCNV amplitude was more pronounced in migraine patients who were in remission in 2006 and in healthy subjects and less pronounced in migraineurs with persisting headaches. Patients with the worsened migraine demonstrated the most pronounced loss of iCNV habituation in 1998 and significantly increased iCNV amplitudes in 2006. This longitudinal study supports the hypothesis of impaired cerebral maturation in migraine and shows that migraine manifestation is a key factor interfering with the natural maturation process of central information processing.
Siniatchkin
Michael
M
Department of Child Neurology, Christian-Albrechts-University of Kiel, Schwanenweg 20, Kiel, Germany. m.siniatchkin@pedneuro.uni-kiel.de
Jonas
Anne
A
Baki
Huelya
H
van Baalen
Andreas
A
Gerber
Wolf-Dieter
WD
Stephani
Ulrich
U
D000293:Adolescent; D000375:Aging / Q000502:physiology*; D002540:Cerebral Cortex / Q000254:growth & development* / Q000503:physiopathology*; D002648:Child; D002908:Chronic Disease; D003265:Contingent Negative Variation / Q000502:physiology*; D018450:Disease Progression; D004568:Electrodiagnosis; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006185:Habituation, Psychophysiologic / Q000502:physiology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008881:Migraine Disorders / Q000209:etiology* / Q000503:physiopathology*; D012720:Severity of Illness Index; D013997:Time Factors