Rab3 GTPase lands Bruchpilot.
Active zones are the sites of neurotransmitter release, but their assembly mechanisms are poorly understood. In this issue of Neuron, Graf et al. perform a genetic screen in Drosophila and uncover a novel role for the Rab3 GTPase in organizing the active zone at the neuromuscular junction.
Giagtzoglou
Nikolaos
N
Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Mahoney
Timothy
T
Yao
Chi-Kuang
CK
Bellen
Hugo J
HJ
D000818:Animals; D002118:Calcium / Q000378:metabolism; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism*; D020558:GTP Phosphohydrolases / Q000235:genetics / Q000378:metabolism; D009469:Neuromuscular Junction / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure; D017729:Presynaptic Terminals / Q000378:metabolism* / Q000648:ultrastructure; D015398:Signal Transduction / Q000502:physiology; D020692:rab3 GTP-Binding Proteins / Q000378:metabolism*
C510146:BRP protein, Drosophila; D029721:Drosophila Proteins; D020558:GTP Phosphohydrolases; C000607807:Rab3 protein, Drosophila; D020692:rab3 GTP-Binding Proteins; D002118:Calcium