Dissociating the conditioning and the anorectic effects of estradiol in female rats.
The present series of experiments challenges the ability of the hormone estradiol to act as an unconditioned stimulus in the conditioned taste avoidance (CTA) learning paradigm. We hypothesize that reductions in sucrose consumption observed after pairing it with estradiol are not indicative of associative learning, but due to the unconditioned expression of estradiol's anorectic effects during the time of CTA assessment. Three experiments in which a sucrose solution was paired with estradiol were conducted to test this hypothesis. Experiment 1 demonstrated that female rats expressed a reduction in post-pairing sucrose consumption even though the anorectic effects of estradiol had subsided. Experiment 2 showed that although a low dose of estradiol produced anorexia, it did not elicit post-pairing reductions in sucrose consumption. Experiment 3 revealed that contingent pairing was a requirement for post-pairing reduction in sucrose consumption even when testing was done at a time when anorexia is expressed. These findings demonstrate the dissociability of the conditioning and anorectic effects of estradiol, providing evidence against the hypothesis. The results are discussed in terms of independent neural mechanisms underlying the disparate behaviors.
Hintiryan
Houri
H
Department of Psychology, University of Southern California, USA. hintirya@gmail.com
Foster
Nicholas N
NN
Chambers
Kathleen C
KC
D000704:Analysis of Variance; D000818:Animals; D001245:Association Learning / Q000187:drug effects; D001362:Avoidance Learning / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley
D004967:Estrogens; D004958:Estradiol