title: Effects of subchronic simazine exposure on some biometric, biochemical, hematological and histopathological parameters of common carp (Cyprinus carpio L.).
abstract: OBJECTIVE
  This study assessed the subchronic effects of a triazine compound, simazine, on common carp (Cyprinus carpio L.) though, via by means of biometric, biochemical, hematological, and histological examination.
  
  
  METHODS
  One-year-old fish were exposed to simazine at four concentrations, 0.06, (reported concentration in Czech rivers), 4, 20, and 50 microg L-1 for 28 days and compared to carp in a non-treated control group.
  
  
  RESULTS
  Exposure of fish to simazine at 0.06 microg L-1 had no effect on measured parameters. However, exposure to simazine at the concentrations of 4, 20, 50 microg L-1 showed significant differences in biochemical, hematological, and histopathological profiles of fish compared to controls.
  
  
  CONCLUSIONS
  Our data suggest that simazine in the recorded environmental concentration 0.06 microg L-1 had no effect on common carp. Subchronic exposure to 4, 20, and 50 microg L-1 of simazine was associated with alterations in biochemical and hematological indices and in fish organ tissues.
authors.affiliation: Research Institute of Fish Culture and Hydrobiology Vodnany, University of South Bohemia, Ceske Budejovice, Czech Republic. velisek@vurh.jcu.cz
authors.forename: Jozef
authors.initials: J
authors.lastname: Velisek
authors.forename: Kamila
authors.initials: K
authors.lastname: Stastna
authors.forename: Eliska
authors.initials: E
authors.lastname: Sudova
authors.forename: Jan
authors.initials: J
authors.lastname: Turek
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Svobodova
mesh_terms: D000818:Animals; D002347:Carps / Q000502:physiology*; D018153:Czech Republic; D004305:Dose-Response Relationship, Drug; D006540:Herbicides / Q000008:administration & dosage / Q000633:toxicity*; D011897:Random Allocation; D045483:Rivers; D012839:Simazine / Q000008:administration & dosage / Q000633:toxicity*; D018675:Toxicity Tests; D014873:Water Pollutants / Q000008:administration & dosage / Q000633:toxicity
chemical_list: D006540:Herbicides; D014873:Water Pollutants; D012839:Simazine