ATP as modulator of carbacholine effect on contractility of rat myocardium in postnatal ontogeny.
We studied combined effect of 2-m-ATP, P(2) receptor agonist, and carbacholine, muscarinic M(2) cholinoreceptor agonist, on contractility of rat myocardium during the postnatal ontogeny. Activation of P(2) receptors can stimulate or attenuate the effects of carbacholine depending on animal age. 2-m-ATP potentiates the inhibitory effect of carbacholine on myocardial contractility in 14- and 100-day-old rats. In 21-day-old rats, activation of P(2) receptors prevented the negative effect of carbacholine on myocardial contractility. Activation of muscarinic M(2) receptors inhibited the inotropic effect of purine in all age groups.
Anikina
T A
TA
Department of Anatomy, Physiology, and Human Health Protection, Tatar State Humanitarian Pedagogical University, Kazan, Tatarstan, Russia.
Sitdikov
F G
FG
Zverev
A A
AA
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D018679:Cholinergic Agonists / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D058910:Purinergic P2 Receptor Agonists; D051381:Rats; D043585:Receptor, Muscarinic M2 / Q000819:agonists
D018679:Cholinergic Agonists; D058910:Purinergic P2 Receptor Agonists; D043585:Receptor, Muscarinic M2; D000255:Adenosine Triphosphate; D002217:Carbachol