title: Towards an asymmetric synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin.
abstract: Studies towards the synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin are reported. The synthetic approach features an organocatalytic access to the alpha,alpha-disubstituted amino acid unit and results in the synthesis of an advanced intermediate which already contains all functionalities of fumimycin.
authors.affiliation: Institut für Organische Chemie, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany.
authors.forename: Caroline E
authors.initials: CE
authors.lastname: Hartmann
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Gross
authors.forename: Martin
authors.initials: M
authors.lastname: Nieger
authors.forename: Stefan
authors.initials: S
authors.lastname: Bräse
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D000596:Amino Acids / Q000737:chemistry; D001572:Benzofurans / Q000138:chemical synthesis*
chemical_list: D000596:Amino Acids; D001572:Benzofurans; C522224:fumimycin; D000581:Amidohydrolases; C084507:peptide deformylase