Comparison of outcomes after extended thymectomy for myasthenia gravis: bilateral thoracoscopic approach versus sternotomy.
Minimally invasive thymectomy procedures have been proposed for nonthymomatous myasthenia gravis. However, few reports stressed that the lower invasiveness or cosmetic benefits also evaluated the rationale of a thymectomy, which is performed to remove as much thymic tissue as possible. We retrospectively reviewed 30 consecutive patients who underwent a bilateral video-assisted thoracoscopic extended thymectomy (VATET) and compared the results with those of 26 patients who underwent a transsternal extended thymectomy (TSET) to determine the amount of removed thymic tissue and clinical prognosis. The amount of blood loss during the operation for VATET (median 60 mL; range nearly 0 to 940 mL) was significantly lower as compared with that of TSET. The median weight of removed thymic tissue (37.0 g; 18.3 to 100.0 g) and remission rates (1 y: 12.5%; 3 y: 30.8%; 4 y: 44.4%) of VATET were comparable with those of TSET. The VATET group had a similar amount of thymo-fatty tissue removed and feasible clinical outcomes as compared with the TSET group, indicating that VATET provides a proper balance between less invasiveness and radical capability.
Shiono
Hiroyuki
H
General Thoracic Surgery, Osaka University Graduate School of Medicine, Yamadaoka, Suita-City, Osaka, Japan. hshiono@nara.med.kindai.ac.jp
Kadota
Yoshihisa
Y
Hayashi
Akio
A
Okumura
Meinoshin
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D001835:Body Weight; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D056346:Sternotomy / Q000379:methods*; D020775:Thoracic Surgery, Video-Assisted / Q000295:instrumentation / Q000379:methods*; D013934:Thymectomy / Q000379:methods*; D013950:Thymus Gland / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult