Evaluation of candidate genes as a cause of chondrodysplasia in Labrador retrievers.
Chondrodysplasia (CD) is a disabling, hereditary disease in Labradors with short limbs, warranting genetic screening in families at risk. Segregation analysis of eight litters with 13 affected dogs showed that autosomal recessive inheritance was consistent with the observed incidence of CD in the litters. Possible involvement of eight candidate collagen genes (COL9A1, COL9A2, COL9A3, COMP, MATN3, COL2A1, COL11A1 and COL11A2) and of a sulfate transporter glycoprotein (SLC26A2) gene in eight affected dogs and in 14 related control Labradors was investigated. Assuming recessive inheritance, the candidate genes could not be implicated in CD.
Smit
Jelke Jan
JJ
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, PO Box 80154, 3508 TD Utrecht, The Netherlands.
Temwitchitr
Jedee
J
Brocks
Bouvien A W
BA
Nikkels
Peter G J
PG
Hazewinkel
Herman A W
HA
Leegwater
Peter A J
PA
D000818:Animals; D016022:Case-Control Studies; D003094:Collagen / Q000235:genetics*; D004283:Dog Diseases / Q000453:epidemiology / Q000235:genetics*; D004285:Dogs; D005260:Female; D005808:Genes, Recessive; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006023:Glycoproteins / Q000235:genetics*; D008297:Male; D010009:Osteochondrodysplasias / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D011110:Polymorphism, Genetic
D005819:Genetic Markers; D006023:Glycoproteins; D003094:Collagen