title: [A case of recurrent breast cancer responding to vinorelbine/trastuzumab combination therapy].
abstract: A 60-year-old woman with Stage II, ER-positive, PgR-positive, HER2 (2+) cancer in the right breast underwent right mastectomy with right axillary dissection after chemotherapy with EC followed by docetaxel (DOC) alone. Exemestane was used for postoperative adjuvant treatment. She underwent a right chest wall tumor resection for local recurrence. Hormone therapy was continued with toremifene in place of exemestane. In December 2007, two years after the second surgery, CEA was elevated and PET showed a local recurrence in the right chest wall and metastases to the right axillary nodes and liver. The tumor was ER-positive, PgR-negative and HER2 (3+) at recurrence, and vinorelbine/trastuzumab combination was initiated as first-line chemotherapy for the recurrent lesion and liver metastasis. All lesions in the right chest wall, right axillary nodes and liver disappeared from PET and CT images after five courses of the regimen, resulting in clinical CR. Vinorelbine combined with trastuzumab appears to be a useful therapy for HER2-positive recurrent breast cancer.
authors.affiliation: Dept. of General Surgery, Juntendo University Nerima Hospital.
authors.forename: Minoru
authors.initials: M
authors.lastname: Fujisawa
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Uomori
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takehara
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Mitsugi
authors.forename: Kouhei
authors.initials: K
authors.lastname: Yoshino
authors.forename: Masafumi
authors.initials: M
authors.lastname: Okumura
authors.forename: Michio
authors.initials: M
authors.lastname: Machida
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kitabatake
authors.forename: Yoshirou
authors.initials: Y
authors.lastname: Ishibiki
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Kojima
authors.forename: Kanako
authors.initials: K
authors.lastname: Ogura
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Matsumoto
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D000068878:Trastuzumab; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077235:Vinorelbine
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D000068878:Trastuzumab; D000077235:Vinorelbine