title: Fatty-Acid-induced apoptosis in ehrlich ascites tumor cells.
abstract: The unsaturated fatty acids oleic acid and arachidonic acid induced typical apoptosis in Ehrlich ascites tumor cells harvested at the stationary growth phase. Arachidonic acid was a more potent inducer than oleic acid. Apoptosis was induced by concentrations of oleic and arachidonic acids that produced only partial uncoupling of the oxidative phosphorylation. The first symptoms of fatty-acid-induced apoptosis included externalization of phosphatidylserine in the plasma membrane, whereas massive release of cytochrome c from mitochondria to the cytosol followed later on.
authors.affiliation: Nencki Institute of Experimental Biology, Warsaw, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Dymkowska
authors.forename: Joanna
authors.initials: J
authors.lastname: Szczepanowska
authors.forename: Lech
authors.initials: L
authors.lastname: Wojtczak