title: Evaluation of prognostic factors and establishment of a prognostic scoring system for canine primary immune-mediated hemolytic anemia.
abstract: Clinical courses of primary immune-mediated hemolytic anemia (pIMHA) in dogs are highly variable, however, limited information is available to predict their accurate prognoses. To evaluate the prognostic significance of clinical factors and to propose a scoring system to predict prognoses, the medical records of seventy-one dogs with pIMHA were reviewed. Overall mortality rate of dogs with pIMHA was 39% and most of the dogs died within 3 months from diagnosis. Sex, body weight, seasonality, packed corpuscular volume (PCV), platelet count (PLT), total plasma protein (TP), blood urea nitrogen, albumin, total bilirubin, sodium ion, prothrombin time, and fibrin/fibrinogen degradation products before immunosuppressive treatment can influence on survival time in dogs with pIMHA. A prognostic scoring system using a combination of sex, seasonality, PCV, PLT and TP can be statistically significant for raising the accuracy of prognostic prediction. Using the scoring system for prognostication in dogs with pIMHA may enable veterinarians to predict a prognosis easily and accurately.
authors.affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ishihara
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Fujino
authors.forename: Asuka
authors.initials: A
authors.lastname: Setoguchi
authors.forename: Masashi
authors.initials: M
authors.lastname: Takahashi
authors.forename: Ko
authors.initials: K
authors.lastname: Nakashima
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohno
authors.forename: Hajime
authors.initials: H
authors.lastname: Tsujimoto
mesh_terms: D000743:Anemia, Hemolytic / Q000209:etiology / Q000276:immunology / Q000401:mortality / Q000662:veterinary*; D000818:Animals; D001663:Bilirubin / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D001806:Blood Urea Nitrogen; D004285:Dogs / Q000276:immunology*; D005260:Female; D006384:Hemagglutination; D008297:Male; D010976:Platelet Count; D011379:Prognosis; D012621:Seasons; D013045:Species Specificity; D015996:Survival Rate; D013921:Thrombocytopenia / Q000150:complications / Q000662:veterinary; D014611:Vaccination / Q000662:veterinary
chemical_list: D001798:Blood Proteins; D001663:Bilirubin