Preimplantation genetic diagnosis.
Couples at risk for having an affected child with homozygous thalassemia or other serious hemoglobin disorder have various options for prevention. The most used in some countries has been prenatal diagnosis with a choice of termination of pregnancy. A more recent addition is preimplantation genetic diagnosis (PGD). In this article, this method is described and reviewed.
Petrou
Mary
M
Haemoglobinopathy Genetics Centre, Institute of Women's Health, University College London, University College, London, Hospitals NHS Foundation Trust, London, UK. M.Petrou@ucl.ac.uk
D005260:Female; D005307:Fertilization in Vitro; D006580:Genetic Carrier Screening; D005817:Genetic Counseling; D006453:Hemoglobinopathies / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000379:methods*; D011296:Prenatal Diagnosis