Advances in radionuclide molecular imaging in myocardial biology.
Molecular imaging is a new and evolving field that employs a targeted approach to noninvasively assess biologic processes in vivo. By assessing key elements in specific cellular processes prior to irreversible end-organ damage, molecular tools will allow for earlier detection and intervention, improving management and outcomes associated with cardiovascular diseases. The goal of those working to expand this field is not just to provide diagnostic and prognostic information, but rather to guide an individual's pharmacological, cell-based, or genetic therapeutic regimen. This article will review molecular imaging tools in the context of our current understanding of biological processes of the myocardium, including angiogenesis, ventricular remodeling, inflammation, and apoptosis. The focus will be on radiotracer-based molecular imaging modalities with an emphasis on clinical application. Though this field is still in its infancy and may not be fully ready for widespread use, molecular imaging of myocardial biology has begun to show promise of clinical utility in acute and chronic ischemia, acute myocardial infarction, congestive heart failure, as well as in more global inflammatory and immune-mediated responses in the heart-like myocarditis and allogeneic cardiac transplant rejection. With continued research and development, molecular imaging promises to be an important tool for the optimization of cardiovascular care.
Morrison
Alan R
AR
Section of Cardiovascular Medicine, Department of Medicine, Yale University School of Medicine, P.O. Box 208017, New Haven, CT 06520-8017, USA.
Sinusas
Albert J
AJ
D002309:Cardiology / Q000639:trends*; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging*; D006801:Humans; D015336:Molecular Probe Techniques / Q000639:trends*; D009683:Nuclear Medicine / Q000639:trends*; D011868:Radioisotopes; D014055:Tomography, Emission-Computed / Q000639:trends*
D011868:Radioisotopes