title: Diverse roles of the actin cytoskeleton in striated muscle.
abstract: In addition to the highly specialized contractile apparatus, it is becoming increasingly clear that there is an extensive actin cytoskeleton which underpins a wide range of functions in striated muscle. Isoforms of cytoskeletal actin and actin-associated proteins (non-muscle myosins, cytoskeletal tropomyosins, and cytoskeletal alpha-actinins) have been detected in a number of regions of striated muscle: the sub-sarcolemmal costamere, the Z-disc and the T-tubule/sarcoplasmic reticulum membranes. As the only known function of these proteins is through association with actin filaments, their presence in striated muscles indicates that there are spatially and functionally distinct cytoskeletal actin filament systems in these tissues. These filaments are likely to have important roles in mechanical support, ion channel function, myofibrillogenenous and vesicle trafficking.
authors.affiliation: Department of Anatomy, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Kee
authors.forename: Peter W
authors.initials: PW
authors.lastname: Gunning
authors.forename: Edna C
authors.initials: EC
authors.lastname: Hardeman
mesh_terms: D008841:Actin Cytoskeleton / Q000502:physiology* / Q000648:ultrastructure; D000199:Actins / Q000502:physiology* / Q000648:ultrastructure; D003599:Cytoskeleton / Q000502:physiology* / Q000648:ultrastructure; D009119:Muscle Contraction / Q000502:physiology; D009124:Muscle Proteins / Q000502:physiology; D054792:Muscle, Striated / Q000502:physiology* / Q000648:ultrastructure; D012508:Sarcolemma / Q000502:physiology / Q000648:ultrastructure; D012519:Sarcoplasmic Reticulum / Q000502:physiology / Q000648:ultrastructure
chemical_list: D000199:Actins; D009124:Muscle Proteins