title: Effects of instrumental dead space reduction during weaning from synchronized ventilation in preterm infants.
abstract: OBJECTIVE
  A majority of the modalities of synchronized ventilation in preterm infants require the use of flow sensors that can increase dead space and may adversely affect ventilator weaning. The objective of this study was to assess the effects of flow sensor dead space during synchronized intermittent mandatory ventilation (SIMV) weaning in preterm infants.
  
  
  METHODS
  Twelve preterm infants (gestational age 25+/-2 weeks, birth weight 705+/-158 g, age: 31+/-186 days, SIMV rate: 25+/-8 breaths min(-1), peak inspiratory pressure 18+/-2 cm H(2)O, positive end-expiratory pressure: 5+/-0.5 cm H(2)O, pressure support: 9+/-3 cm H(2)O, fraction of inspired oxygen: 34+/-6%) underwent two 2.5-h weaning periods during which SIMV rate was reduced twice by 5 breaths min(-1) at 30-min intervals as tolerated, with and without reduction of flow sensor dead space, in random sequence. A 30-min baseline was obtained before each weaning period. Dead space was reduced by flushing the flow sensor with a continuous gas leak flow in the endotracheal tube connector.
  
  
  RESULTS
  Transcutaneous CO(2) tension during SIMV weaning periods without and with reduced dead space did not differ from baseline, whereas total minute ventilation and tidal volume were lower during the SIMV weaning period with reduced dead space. Three infants did not tolerate SIMV weaning without while one infant did not tolerate weaning with reduced dead space.
  
  
  CONCLUSIONS
  SIMV weaning elicited a compensatory rise in spontaneous ventilation. When flow sensor dead space was reduced during SIMV weaning, gas exchange was maintained with lower minute ventilation. Instrumental dead space imposes a ventilatory burden during SIMV weaning in small preterm infants.
authors.affiliation: Pontificia Universidad Catolica de Chile, Santiago, Chile.
authors.forename: A
authors.initials: A
authors.lastname: Estay
authors.forename: N
authors.initials: N
authors.lastname: Claure
authors.forename: C
authors.initials: C
authors.lastname: D'Ugard
authors.forename: R
authors.initials: R
authors.lastname: Organero
authors.forename: E
authors.initials: E
authors.lastname: Bancalari
mesh_terms: D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007385:Intermittent Positive-Pressure Ventilation; D008297:Male; D047928:Premature Birth; D012126:Respiratory Dead Space; D015300:Ventilator Weaning / Q000379:methods*