title: One hundred pancreas transplants performed in a Brazilian institution.
abstract: After decades of controversy surrounding the therapeutic validity of pancreas transplantation, the procedure has become accepted as the preferred treatment for selected patients with type 1 diabetes mellitus. Between January 2001 and January 2008, 100 patients underwent pancreatic transplantation at our center: 88 simultaneous pancreas-kidney transplantation and 12 pancreas transplantations alone. Pancreas graft management of the exocrine drainage technique involved enteric drainage in 8 (all simultaneous pancreas-kidney) and the bladder in 92 cases. The recipient systemic venous system was used for the pancreas graft venous effluent in all cases. Our overall results have shown that the number of functioning pancreatic grafts was 64 of 100. Graft losses were: rejection (n = 8), venous thrombosis (n = 9), arterial thrombosis (n = 1), or surgical complications such as anastomotic leak (n = 3), perigraft infection (n = 10), pancreatitis of the graft (n = 5). Most cases of pancreatitis (80%) had preservation times exceeding 18 hours. Despite surgical and immunosuppressive complications, our impression was that pancreas transplantation was a highly effective therapy for diabetes mellitus. After 7 years of the program and 100 transplantations, we believe that there is a major role for transplantation in diabetes management.
authors.affiliation: Department of Medicine, PUC-PR Brazil. jenicoluzz@yahoo.com
authors.forename: J
authors.initials: J
authors.lastname: Nicoluzzi
authors.forename: F
authors.initials: F
authors.lastname: Silveira
authors.forename: F
authors.initials: F
authors.lastname: Porto
authors.forename: M
authors.initials: M
authors.lastname: Macri
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil; D002102:Cadaver; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D003928:Diabetic Nephropathies / Q000601:surgery; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology / Q000706:statistics & numerical data; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000276:immunology / Q000379:methods / Q000706:statistics & numerical data*; D012042:Registries; D012189:Retrospective Studies; D016559:Tacrolimus / Q000627:therapeutic use; D014019:Tissue Donors; D016896:Treatment Outcome; D014481:United States
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus