title: The plant-derived natural compound Flavin 7 attenuates oxidative stress in cultured renal proximal tubule cells.
abstract: BACKGROUND
  Cancer therapies and cancer progression can increase oxidative stress that might account for renal toxicity in cancer patients. Flavin 7 (F7) is a natural polyphenol-containing dietary supplement with potential antioxidant activity. Therefore, it might help to attenuate renal toxicity of chemotherapeutics.
  
  
  METHODS
  Cultured mouse renal proximal tubule cells were subjected to H(2)O(2)-mediated oxidative stress. Potential antioxidant effects of F7 were assessed by measuring the production of reactive oxygen species (ROS), mitochondrial depolarization and injury (lactate dehydrogenase release as well as trypan blue exclusion) in cells that were pretreated with F7 prior to treatment with H(2)O(2).
  
  
  RESULTS
  F7 pretreatment significantly attenuated H(2)O(2)-induced ROS production, mitochondrial depolarization and consequent injury in renal proximal tubule cells.
  
  
  CONCLUSIONS
  F7 supplementation might be beneficial for cancer patients in order to prevent renal toxicity of anticancer drug- or cancer progression-related oxidative stress.
authors.affiliation: Department of Surgery, University of Pecs, Hungary.
authors.forename: Agoston
authors.initials: A
authors.lastname: Ember
authors.forename: Jeb S
authors.initials: JS
authors.lastname: Clark
authors.forename: Timea
authors.initials: T
authors.lastname: Varjas
authors.forename: Istvan
authors.initials: I
authors.lastname: Kiss
authors.forename: Istvan
authors.initials: I
authors.lastname: Ember
authors.forename: Radhakrishna
authors.initials: R
authors.lastname: Baliga
authors.forename: Istvan
authors.initials: I
authors.lastname: Arany
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001562:Benzimidazoles / Q000378:metabolism; D002232:Carbocyanines / Q000378:metabolism; D002461:Cell Line, Transformed; D002470:Cell Survival / Q000187:drug effects; D005456:Fluorescent Dyes / Q000378:metabolism; D005638:Fruit / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000633:toxicity; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D051379:Mice; D051336:Mitochondrial Membranes / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001562:Benzimidazoles; D002232:Carbocyanines; D005456:Fluorescent Dyes; D010936:Plant Extracts; D017382:Reactive Oxygen Species; C068624:5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine; D006861:Hydrogen Peroxide; D007770:L-Lactate Dehydrogenase