title: Coexistence of basal cell carcinomas and multiple sebaceous gland hyperplasias in a cyclosporine (ciclosporin)-treated renal transplant recipient.
abstract: A 55-year-old man presented with multiple, asymptomatic, yellowish papules on his face with a 4-year history, and two non-healing tumoral lesions on his nose with a 7-month history. He was a renal transplant recipient and had been treated with cyclosporine (ciclosporin) for 9 years. A biopsy from the asymptomatic, yellowish papule on the face showed sebaceous gland hyperplasia, and biopsies from the lesions on the nose revealed basal cell carcinomas. The lesions on the nose were excised. Sebaceous gland hyperplasia and skin cancers are among the cutaneous neoplasms observed in renal transplant recipients receiving cyclosporine. To our knowledge, this is the third reported case of the coexistence of basal cell carcinomas and multiple sebaceous gland hyperplasias in a cyclosporine-treated renal transplant recipient.
authors.affiliation: Department of Dermatology, Karadeniz Technical University, Trabzon, Turkey. savas_an@yahoo.com
authors.forename: Savaş
authors.initials: S
authors.lastname: Yayli
authors.forename: Hikmet
authors.initials: H
authors.lastname: Akyazi
authors.forename: Sevgi
authors.initials: S
authors.lastname: Bahadir
authors.forename: Köksal
authors.initials: K
authors.lastname: Alpay
authors.forename: Umit
authors.initials: U
authors.lastname: Cobanoğlu
mesh_terms: D002280:Basal Cell Carcinoma / Q000139:chemically induced* / Q000150:complications / Q000473:pathology / Q000601:surgery; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D005145:Face / Q000473:pathology; D006801:Humans; D006965:Hyperplasia / Q000139:chemically induced; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000379:methods; D008297:Male; D008875:Middle Aged; D009666:Nose / Q000473:pathology / Q000601:surgery; D012625:Sebaceous Gland Diseases / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000150:complications / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine