title: Highly enantioselective hydrogenation of alpha-aryl-beta-substituted acrylic acids catalyzed by Ir-SpinPHOX.
abstract: The enantioselective hydrogenation of a series of challenging substrates, alpha-aryl-beta-substituted acrylic acids, was realized with high efficiency and enantioselectivity (up to 96%) under the catalysis of Ir(i) complex of Spiro-based P,N ligand, SpinPHOX.
authors.affiliation: Synthetic Organic & Medicinal Chemistry Laboratory, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhaobin
authors.initials: Z
authors.lastname: Han
authors.forename: Fuying
authors.initials: F
authors.lastname: Li
authors.forename: Kuiling
authors.initials: K
authors.lastname: Ding
authors.forename: Ao
authors.initials: A
authors.lastname: Zhang
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000179:Acrylates; D009942:Organometallic Compounds; D013141:Spiro Compounds; D007495:Iridium; C036658:acrylic acid