title: Dual anti-angiogenic and cytotoxic properties of ruthenium(III) complexes containing pyrazolato and/or pyrazole ligands.
abstract: An oxo-bridged diruthenium(III) complex containing pyrazolato and pyrazole ligands is stable against ascorbic-acid reduction, induces apoptosis (60%, 48 h) against HeLa cells at 10 microM level and exhibits promising anti-angiogenic activity at its sub-cytotoxic concentrations. Other mononuclear ruthenium(III) complexes containing pyrazole ligands [Ru(pz)(4)X(2)](+) exhibit dual anti-angiogenic and cytotoxic properties.
authors.affiliation: Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
authors.forename: Raymond Wai-Yin
authors.initials: RW
authors.lastname: Sun
authors.forename: Miro Fei-Yeung
authors.initials: MF
authors.lastname: Ng
authors.forename: Ella Lai-Ming
authors.initials: EL
authors.lastname: Wong
authors.forename: Jingfei
authors.initials: J
authors.lastname: Zhang
authors.forename: Stephen Sin-Yin
authors.initials: SS
authors.lastname: Chui
authors.forename: Lam
authors.initials: L
authors.lastname: Shek
authors.forename: Tai-Chu
authors.initials: TC
authors.lastname: Lau
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis; D001205:Ascorbic Acid / Q000737:chemistry; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry / Q000633:toxicity*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D008024:Ligands; D008968:Molecular Conformation; D011720:Pyrazoles / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D020533:Angiogenesis Inhibitors; D056831:Coordination Complexes; D008024:Ligands; D011720:Pyrazoles; C031280:pyrazole; D012428:Ruthenium; D001205:Ascorbic Acid