Asymmetric synthesis of alpha-tocopherol.
Alpha-tocopherol was synthesized from a chiral intermediate alpha-hydroxy ester by means of two ring-closing methods to yield the chromanol in 94% diastereomeric excess.
Hengartner
Urs
U
Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland.
Chougnet
Antoinette
A
Liu
Kegang
K
Woggon
Wolf-D
WD
D002839:Chromans / Q000737:chemistry; D003500:Cyclization; D013237:Stereoisomerism; D024502:alpha-Tocopherol / Q000138:chemical synthesis* / Q000737:chemistry
D002839:Chromans; C029141:2,2,5,7,8-pentamethyl-1-hydroxychroman; D024502:alpha-Tocopherol