A G-coupled receptor protein critical for peripheral nerve myelination.
Intercellular signaling between the axon and myelinating glial cells plays an essential role in the regulation of the myelination process. A recent study from Monk et al. has used a forward genetics approach in zebrafish to identify a G protein-coupled receptor that is necessary for Schwann cells to myelinate axons, thereby uncovering a critical component of the axo-glial signaling network.
Howng
Shen Yi B
SY
The Jack Miller Center for Peripheral Neuropathy, Department of Neurology, The University of Chicago, 5841 South Maryland Avenue, MC2030, Chicago, IL 60637, USA.
Douglas
Darlene S
DS
Popko
Brian
B
D000818:Animals; D001369:Axons / Q000378:metabolism; D051767:Early Growth Response Protein 2 / Q000378:metabolism; D009186:Myelin Sheath / Q000502:physiology*; D020890:Neuregulin-1 / Q000378:metabolism; D027701:Organic Cation Transport Proteins / Q000378:metabolism; D010525:Peripheral Nerves / Q000166:cytology / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D012583:Schwann Cells / Q000166:cytology / Q000378:metabolism; D015398:Signal Transduction; D015027:Zebrafish / Q000235:genetics / Q000378:metabolism
D051767:Early Growth Response Protein 2; D020890:Neuregulin-1; D027701:Organic Cation Transport Proteins; D043562:Receptors, G-Protein-Coupled