title: Dendron-anchored organocatalysts: the asymmetric reduction of imines with trichlorosilane, catalysed by an amino acid-derived formamide appended to a dendron.
abstract: Asymmetric reduction of ketimines with trichlorosilane can be catalysed by the Lewis-basic N-methylvaline-derived formamide anchored to a soluble dendron () with good enantioselectivity (</=94% ee) and low catalyst loading (typically 5 mol%) at room temperature in toluene. This protocol represents an improvement and simplification of the isolation procedure and recovery of the catalyst.
authors.affiliation: WestCHEM, Department of Chemistry, Joseph Black Building, University of Glasgow, UK.
authors.forename: Marek
authors.initials: M
authors.lastname: Figlus
authors.forename: Stuart T
authors.initials: ST
authors.lastname: Caldwell
authors.forename: Dawid
authors.initials: D
authors.lastname: Walas
authors.forename: Gulen
authors.initials: G
authors.lastname: Yesilbag
authors.forename: Graeme
authors.initials: G
authors.lastname: Cooke
authors.forename: Pavel
authors.initials: P
authors.lastname: Kocovský
authors.forename: Andrei V
authors.initials: AV
authors.lastname: Malkov
authors.forename: Amitav
authors.initials: A
authors.lastname: Sanyal
mesh_terms: D000873:Anthracenes / Q000737:chemistry*; D002384:Catalysis; D005559:Formamides / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D010084:Oxidation-Reduction; D012821:Silanes / Q000737:chemistry*
chemical_list: D000873:Anthracenes; D005559:Formamides; D007097:Imines; D012821:Silanes; C501244:dendron; C031066:formamide; C065893:trichlorosilane