Constipation in pediatric cystic fibrosis patients: an underestimated medical condition.
BACKGROUND
The aims of this study were to determine prevalence, risk factors and treatment of constipation in patients with Cystic Fibrosis (CF), as well as the diagnostic value of abdominal radiography.


METHODS
A cohort of 214 pediatric CF patients was investigated. Furthermore, 106 abdominal radiographs of CF patients with or without constipation were independently assessed by three observers on two separate occasions using the Barr and Leech scores.


RESULTS
The prevalence of constipation was 47%. Low total fat absorption and meconium ileus were independent risk factors for constipation in CF, while fiber and fluid intake were not associated. In CF patients the inter and intraobserver variabilities of the Barr and Leech scores were poor to moderate.


CONCLUSIONS
Constipation is a significant medical issue in CF and was associated with low total fat absorption and a history of meconium ileus. Finally, abdominal radiography seems of little value in the regular follow-up of CF patients.
van der Doef
H P J
HP
Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, 3584 EA, Utrecht, The Netherlands. H.P.J.vanderdoef@umcutrecht.nl <H.P.J.vanderdoef@umcutrecht.nl>
Kokke
F T M
FT
Beek
F J A
FJ
Woestenenk
J W
JW
Froeling
S P
SP
Houwen
R H J
RH
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003248:Constipation / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D003550:Cystic Fibrosis / Q000453:epidemiology*; D004041:Dietary Fats / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D045823:Ileus / Q000000981:diagnostic imaging / Q000453:epidemiology; D007231:Infant, Newborn; D007408:Intestinal Absorption; D008286:Malabsorption Syndromes / Q000000981:diagnostic imaging / Q000453:epidemiology; D008297:Male; D008470:Meconium; D015588:Observer Variation; D015995:Prevalence; D011860:Radiography, Abdominal / Q000706:statistics & numerical data*; D012307:Risk Factors; D045602:Steatorrhea / Q000000981:diagnostic imaging / Q000453:epidemiology
D004041:Dietary Fats