title: Neonatal small left colon syndrome in the offspring of diabetic mothers-an analysis of 105 children.
abstract: OBJECTIVE
  Neonatal small left colon syndrome (NSLCS) is considered a rare cause of neonatal intestinal obstruction, with few documented cases in the English literature. Maternal diabetes has been reported in 40% to 50% of the published cases of NSLCS. Currently, the incidence of maternal diabetes is increasing, but there has been no study to ascertain the incidence and significance of NSLCS in this population. This review aims to assess the current significance of NSLCS and its association with maternal diabetes.
  
  
  METHODS
  This was a retrospective review of 105 offspring of diabetic mothers who were admitted during the period 2004 to 2008 to our neonatal unit with special emphasis on associated NSLCS.
  
  
  RESULTS
  There were 6 cases of intestinal obstruction in this group of 105 children. Five children, including a pair of twins, had classic features of NSLCS as demonstrated in the contrast enema with an abrupt transition at the splenic flexure and a narrow left colon. Conservative treatment was successful in all, negating the need for further invasive investigation. The sixth child had rectosigmoid Hirschprung disease. During the study period, there were no other cases of NSLCS in the nondiabetic population.
  
  
  CONCLUSIONS
  Neonatal small left colon syndrome is the most common cause of intestinal obstruction in offspring of diabetic mothers. Neonatal small left colon syndrome can be confidently diagnosed in this population based on the classic clinical and radiologic findings. The incidence of NSLCS can be expected to increase as the incidence of maternal diabetes increases.
authors.affiliation: John Hunter Children's Hospital, NSW 2310, Australia.
authors.forename: Helen
authors.initials: H
authors.lastname: Ellis
authors.forename: Rajendra
authors.initials: R
authors.lastname: Kumar
authors.forename: Ben
authors.initials: B
authors.lastname: Kostyrka
mesh_terms: D002648:Child; D016241:Child of Impaired Parents / Q000706:statistics & numerical data*; D003106:Colon / Q000002:abnormalities* / Q000000981:diagnostic imaging; D003108:Colonic Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology*; D003974:Diatrizoate Meglumine; D004733:Enema / Q000379:methods; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007415:Intestinal Obstruction / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000453:epidemiology*; D011860:Radiography, Abdominal / Q000706:statistics & numerical data; D012189:Retrospective Studies; D013577:Syndrome
chemical_list: D003974:Diatrizoate Meglumine