title: Function of TopBP1 in genome stability.
abstract: Human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and its orthologues in other organisms are proteins consisting of multiple BRCT modules that have acquired several functions during evolution. These proteins execute their tasks by interacting with a great variety of proteins involved in nuclear processes. TopBP1 is an essential protein that has numerous roles in the maintenance of the genomic integrity. In particular, it is required for the activation of ATM and Rad3-related (ATR), a vital regulator of DNA replication and replication stress response. The orthologues from yeast to human are involved in DNA replication and DNA damage response, while only proteins from higher eukaryotes are also involved in complex regulation of transcription, which is related to cell proliferation, damage response and apoptosis. We review here the recent progress in research aimed at elucidating the multiple cellular functions of TopBP1, focusing on metazoan systems.
authors.affiliation: DNA Damage Response Laboratory, Biochemistry, School of Natural Sciences, National University of Ireland, Galway, Ireland.
authors.forename: Miiko
authors.initials: M
authors.lastname: Sokka
authors.forename: Sinikka
authors.initials: S
authors.lastname: Parkkinen
authors.forename: Helmut
authors.initials: H
authors.lastname: Pospiech
authors.forename: Juhani E
authors.initials: JE
authors.lastname: Syväoja
mesh_terms: D000246:Adenosine Diphosphate Ribose / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004249:DNA Damage; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005786:Gene Expression Regulation; D042822:Genomic Instability; D006801:Humans; D008540:Meiosis / Q000502:physiology; D008938:Mitosis / Q000502:physiology; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D014158:Transcription, Genetic; D014466:Ultraviolet Rays
chemical_list: D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C110513:TOPBP1 protein, human; D000246:Adenosine Diphosphate Ribose