title: Availability of pancreatic allograft biopsies via a laparotomy.
abstract: OBJECTIVE
  The aim of this study was to evaluate the availability of a pancreatic allograft biopsy via a laparotpmy.
  
  
  METHODS
  From September 2004 to November 2007, 17 pancreas transplantations were performed: 15 simultaneous pancreas and kidney transplantations (SPK), 1 pancreas transplant alone (PTA), and one pancreas after kidney transplantation (PAK). Thirteen pancreatic allograft biopsies were obtained via an open laparotomy. This study evaluated the complications associated with this procedure, the rate of obtaining an adequate sample, and the relationship between biopsy-proven rejections and laboratory markers. In SPK cases we evaluated the synchronization between pancreas and kidney rejection. The pancreatic samples were diagnosed according to the Drachenberg classification.
  
  
  RESULTS
  No complications resulted from the procedure. The rate of obtaining adequate samples was 84.6%. Pancreas rejection correlated with elevation of the laboratory markers in 71.4%. Simultaneous pancreas and kidney rejection occurred in 62.5%, only kidney in 25%, and only pancreas in 12.5%.
  
  
  CONCLUSIONS
  A pancreas graft biopsy was absolutely imperative to improve the outcome in PTA, and even in SPK cases. A pancreatic allograft biopsy via a laparotomy was a safe, necessary and easy procedure to obtain an accurate diagnosis of rejection among pancreas transplantation patients.
authors.affiliation: Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. hide@surg1.med.kyushu-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Kitada
authors.forename: A
authors.initials: A
authors.lastname: Sugitani
authors.forename: Y
authors.initials: Y
authors.lastname: Okabe
authors.forename: A
authors.initials: A
authors.lastname: Doi
authors.forename: T
authors.initials: T
authors.lastname: Nishiki
authors.forename: Y
authors.initials: Y
authors.lastname: Miura
authors.forename: K
authors.initials: K
authors.lastname: Kurihara
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
mesh_terms: D001706:Biopsy / Q000379:methods*; D006084:Graft Rejection / Q000473:pathology; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology / Q000473:pathology; D007813:Laparotomy / Q000379:methods; D016035:Pancreas Transplantation / Q000473:pathology*; D010529:Peritoneal Cavity / Q000000981:diagnostic imaging / Q000473:pathology; D012189:Retrospective Studies; D014184:Transplantation, Homologous / Q000473:pathology; D014463:Ultrasonography