title: Genomic landscape of meningiomas.
abstract: Meningiomas are one of the most common adult brain tumors. For most patients, surgical excision is curative. However, up to 20% recur. Currently, the molecular determinants predicting recurrence and malignant transformation are lacking. We performed retrospective global genetic and genomic analysis of 85 meningioma samples of various grades. Copy number alterations were assessed by 100K single-nucleotide polymorphism arrays and correlated with gene expression, proliferation indices and clinical outcome. In addition to chromosome 22q loss, which was detected in the majority of clinical samples, chromosome 6q and 14q loss was significantly more common in recurrent tumors and was associated with anaplastic histology. Five "classes" of meningiomas were detected by gene expression analysis that correlated with copy number alterations, recurrent status and malignant histology. These classes more accurately identified recurrent tumors relative to Ki-67 index and extent of surgical resection, and highlight substantial expression heterogeneity between meningiomas. These data offer the most complete description of the genomic landscape of meningiomas, and provide broad genomic information that may be used to further stratify meningioma patients into prognostic risk groups.
authors.affiliation: Department of Human Genetics, UCLA School of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, Calif 90095-7088, USA.
authors.forename: Yohan
authors.initials: Y
authors.lastname: Lee
authors.forename: Jason
authors.initials: J
authors.lastname: Liu
authors.forename: Shilpa
authors.initials: S
authors.lastname: Patel
authors.forename: Timothy
authors.initials: T
authors.lastname: Cloughesy
authors.forename: Albert
authors.initials: A
authors.lastname: Lai
authors.forename: Haumith
authors.initials: H
authors.lastname: Farooqi
authors.forename: David
authors.initials: D
authors.lastname: Seligson
authors.forename: Jun
authors.initials: J
authors.lastname: Dong
authors.forename: Linda
authors.initials: L
authors.lastname: Liau
authors.forename: Donald
authors.initials: D
authors.lastname: Becker
authors.forename: Paul
authors.initials: P
authors.lastname: Mischel
authors.forename: Soheil
authors.initials: S
authors.lastname: Shams
authors.forename: Stanley
authors.initials: S
authors.lastname: Nelson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D005260:Female; D015870:Gene Expression; D015894:Genome, Human; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology; D008579:Meningioma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide