title: Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.
abstract: We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56).
authors.affiliation: Institute of Human Genetics, Life and Brain Center, University of Bonn, Bonn, Germany. e.mangold@uni-bonn.de
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Mangold
authors.forename: Kerstin U
authors.initials: KU
authors.lastname: Ludwig
authors.forename: Stefanie
authors.initials: S
authors.lastname: Birnbaum
authors.forename: Carlotta
authors.initials: C
authors.lastname: Baluardo
authors.forename: Melissa
authors.initials: M
authors.lastname: Ferrian
authors.forename: Stefan
authors.initials: S
authors.lastname: Herms
authors.forename: Heiko
authors.initials: H
authors.lastname: Reutter
authors.forename: Nilma Almeida
authors.initials: NA
authors.lastname: de Assis
authors.forename: Taofik Al
authors.initials: TA
authors.lastname: Chawa
authors.forename: Manuel
authors.initials: M
authors.lastname: Mattheisen
authors.forename: Michael
authors.initials: M
authors.lastname: Steffens
authors.forename: Sandra
authors.initials: S
authors.lastname: Barth
authors.forename: Nadine
authors.initials: N
authors.lastname: Kluck
authors.forename: Anna
authors.initials: A
authors.lastname: Paul
authors.forename: Jessica
authors.initials: J
authors.lastname: Becker
authors.forename: Carola
authors.initials: C
authors.lastname: Lauster
authors.forename: Gül
authors.initials: G
authors.lastname: Schmidt
authors.forename: Bert
authors.initials: B
authors.lastname: Braumann
authors.forename: Martin
authors.initials: M
authors.lastname: Scheer
authors.forename: Rudolf H
authors.initials: RH
authors.lastname: Reich
authors.forename: Alexander
authors.initials: A
authors.lastname: Hemprich
authors.forename: Simone
authors.initials: S
authors.lastname: Pötzsch
authors.forename: Bettina
authors.initials: B
authors.lastname: Blaumeiser
authors.forename: Susanne
authors.initials: S
authors.lastname: Moebus
authors.forename: Michael
authors.initials: M
authors.lastname: Krawczak
authors.forename: Stefan
authors.initials: S
authors.lastname: Schreiber
authors.forename: Thomas
authors.initials: T
authors.lastname: Meitinger
authors.forename: Hans-Erich
authors.initials: HE
authors.lastname: Wichmann
authors.forename: Regine P
authors.initials: RP
authors.lastname: Steegers-Theunissen
authors.forename: Franz-Josef
authors.initials: FJ
authors.lastname: Kramer
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon
authors.forename: Peter
authors.initials: P
authors.lastname: Propping
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Wienker
authors.forename: Michael
authors.initials: M
authors.lastname: Knapp
authors.forename: Michele
authors.initials: M
authors.lastname: Rubini
authors.forename: Peter A
authors.initials: PA
authors.lastname: Mossey
authors.forename: Per
authors.initials: P
authors.lastname: Hoffmann
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
mesh_terms: D002874:Chromosome Mapping; D002971:Cleft Lip / Q000150:complications / Q000235:genetics*; D002972:Cleft Palate / Q000150:complications / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D020641:Polymorphism, Single Nucleotide