title: On the many roles of NH3 ligands in mono- and multinuclear complexes of platinum.
abstract: The role of the NH(3) ligands in the highly successful antitumour agents cisplatin and carboplatin is not fully understood. Suggestions that the ammonia ligands are involved in target recognition through hydrogen bond formation, e.g. with guanine-O6, have been questioned. Here, we review the roles and functions of NH(3) ligands of cis-PtCl(2)(NH(3))(2) and likewise of its trans-isomer in complexes with model nucleobases as well as other N-heterocyclic ligands. Specifically, their roles in hydrogen bonding interactions with nucleobases as well as anions, the influence on acid-base properties of co-ligands, their involvement in condensation reactions, as well as a variety of displacement reactions will be examined. As a result, it can be stated that the ammonia ligands in cis- and trans-Pt(II)(NH(3))(2) entities display additional features to those generally discussed in the last four decades since the discovery of the antitumour activity of cisplatin.
authors.affiliation: Fakultät Chemie, Technische Universität Dortmund, 44221, Dortmund, Germany. pablo.sanz@tu-dortmund.de
authors.forename: Pablo J
authors.initials: PJ
authors.lastname: Sanz Miguel
authors.forename: Michael
authors.initials: M
authors.lastname: Roitzsch
authors.forename: Lu
authors.initials: L
authors.lastname: Yin
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Lax
authors.forename: Lars
authors.initials: L
authors.lastname: Holland
authors.forename: Olga
authors.initials: O
authors.lastname: Krizanovic
authors.forename: Matthias
authors.initials: M
authors.lastname: Lutterbeck
authors.forename: Markus
authors.initials: M
authors.lastname: Schürmann
authors.forename: Edda C
authors.initials: EC
authors.lastname: Fusch
authors.forename: Bernhard
authors.initials: B
authors.lastname: Lippert
mesh_terms: D000641:Ammonia / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D016190:Carboplatin / Q000737:chemistry; D002945:Cisplatin / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008024:Ligands; D008968:Molecular Conformation; D010984:Platinum / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D010984:Platinum; D000641:Ammonia; D016190:Carboplatin; D002945:Cisplatin