title: Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease.
abstract: Chronic inflammation associated with chronic kidney disease predicts all-cause and cardiovascular mortality in hemodialysis patients. Here we sought to evaluate the association between plasma levels of the inflammatory mediator interleukin-6 (IL-6) and mortality and aortic calcification/stiffness in 125 patients at different stages (2-5D) of chronic kidney disease. Using multivariate linear regression, we found that plasma IL-6 was independently associated with C-reactive protein, albumin and the stage of chronic kidney disease, but not the aortic calcification score or pulse wave velocity. During follow-up studies (median of 829 days), 38 patients died, 22 from cardiovascular events. Plasma IL-6 significantly predicted overall and cardiovascular mortality; this association persisted after multiple adjustments or restricting the analysis to pre-dialysis patients. Moreover, IL-6 was a significantly better predictor of mortality than C-reactive protein, albumin or tumor necrosis factor-alpha. Hence, plasma IL-6 independently predicted overall and cardiovascular mortality in patients at different stages of chronic kidney disease; however, whether lowering plasma IL-6 will affect the outcome of chronic kidney disease will require more direct evaluation.
authors.affiliation: INSERM ERI-12 (EA 4292), Amiens F-80054, France.
authors.forename: Daniela V
authors.initials: DV
authors.lastname: Barreto
authors.forename: Fellype C
authors.initials: FC
authors.lastname: Barreto
authors.forename: Sophie
authors.initials: S
authors.lastname: Liabeuf
authors.forename: Mohammed
authors.initials: M
authors.lastname: Temmar
authors.forename: Horst-Dieter
authors.initials: HD
authors.lastname: Lemke
authors.forename: Christophe
authors.initials: C
authors.lastname: Tribouilloy
authors.forename: Gabriel
authors.initials: G
authors.lastname: Choukroun
authors.forename: Raymond
authors.initials: R
authors.lastname: Vanholder
authors.forename: Ziad A
authors.initials: ZA
authors.lastname: Massy
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007155:Immunologic Factors / Q000097:blood*; D007249:Inflammation / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000401:mortality*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D048069:Tumor Necrosis Factors / Q000097:blood
chemical_list: D007155:Immunologic Factors; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D048069:Tumor Necrosis Factors; D002097:C-Reactive Protein