Toll-like receptors 2 and 4 gene polymorphisms in a southeastern Chinese population with tuberculosis.
Polymorphisms of the toll-like receptor 2 (TLR2) gene (Arg677Trp, Arg753Gln) and the TLR4 gene (Asp299Gly, Thr399Ile) were investigated in 205 tuberculosis (TB) patients and 203 controls. Genetic variations were analysed by DNA sequencing. We revealed that these polymorphisms were rare in the southeastern Chinese population and were not associated with susceptibility to TB.
Xue
Y
Y
Institute of Cell Biology, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.
Zhao
Z Q
ZQ
Wang
H J
HJ
Jin
L
L
Liu
C P
CP
Wang
Y
Y
Li
J C
JC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D051197:Toll-Like Receptor 4 / Q000235:genetics*; D014376:Tuberculosis / Q000208:ethnology / Q000235:genetics*; D055815:Young Adult
D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4