Mincle is a long sought receptor for mycobacterial cord factor.
Mycobacterium tuberculosis is a leading killer worldwide, yet the adjuvancy of its cell wall has proven to be a valuable therapeutic tool for vaccination and immunotherapy. Much research effort has focused on the mycobacterial glycolipid trehalose-6,6'-dimycolate (TDM), a potent immunostimulant that is also known as cord factor. Now, the identification of the monocyte-inducible C-type lectin (Mincle) as an essential receptor for TDM provides new insight into the formation of the characteristic granulomas in tuberculosis and an avenue for rational adjuvant design.
Matsunaga
Isamu
I
Laboratory of Cell Regulation, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo-ku Kyoto 606-8507, Japan.
Moody
D Branch
DB
D000818:Animals; D003311:Cord Factors / Q000502:physiology*; D007249:Inflammation / Q000209:etiology; D037181:Lectins, C-Type / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D051379:Mice; D017452:Receptors, IgG / Q000502:physiology; D051193:Toll-Like Receptors / Q000502:physiology
C113583:Clecsf8 protein, mouse; D003311:Cord Factors; D037181:Lectins, C-Type; D008565:Membrane Proteins; D017452:Receptors, IgG; D051193:Toll-Like Receptors