Direct compression behavior of low- and high-methoxylated pectins.
The objective of this study was to evaluate possible usefulness of pectins for direct compression of tablets. The deformation behavior of pectin grades of different degree of methoxylation (DM), namely, 5%, 10%, 25%, 35%, 40%, 50%, and 60% were, examined in terms of yield pressures (YP) derived from Heckel profiles for both compression and decompression and measurements of elastic recovery after ejection. All pectin grades showed a high degree of elastic recovery. DM 60% exhibited most plastic deformation (YP 70.4 MPa) whereas DM 5% (104.6 MPa) and DM 10% (114.7 MPa) least. However, DM 60% gave no coherent tablets, whereas tablet tensile strengths for DM 5% and DM 10% were comparable to Starch 1500. Also, Heckel profiles were similar to Starch 1500. For sieved fractions (180-250 and 90-125 mum) of DM 25% and DM 40% originating from the very same batch, YPs were alike, indicating minor effects of particle size. These facts indicate that DM is important for the compaction behavior, and batch-to-batch variability should also be considered. Therefore, pectins of low degree of methoxylation may have a potential as direct compression excipients.
Salbu
Linda
L
Department of Pharmacy, Drug Transport and Delivery Research Group, University of Tromsoe, 9037 Tromsø, Norway.
Bauer-Brandl
Annette
A
Tho
Ingunn
I
D005079:Excipients / Q000737:chemistry*; D010316:Particle Size; D010368:Pectins; D055585:Physical Phenomena; D011312:Pressure; D013213:Starch / Q000737:chemistry; D013607:Tablets; D013718:Tensile Strength
D005079:Excipients; D013607:Tablets; D010368:Pectins; D013213:Starch