The potential of resveratrol against human gliomas.
There is growing interest in dietary phytochemicals as potential cancer chemopreventive agents. Resveratrol (3,4',5-trihydroxy-trans-stilbene), a naturally occurring phytoalexin that is present in grapes, red wine, berries and peanuts, has been studied extensively for its ability to interfere with multistage carcinogenesis. Resveratrol is known to have antioxidant, anti-inflammatory and antiproliferative effects on a variety of cancer cells in vitro and in various animal models. However, the effect(s) of resveratrol in vivo on humans are still controversial. This study discusses current knowledge with regard to the effects of resveratrol in relation to its potential as a chemopreventive and/or chemotherapeutic molecule against human gliomas.
Gagliano
Nicoletta
N
Department of Human Morphology and Biomedical Sciences 'Cittá Studi, Universitá di Milano, School of Medicine, Extracellular Matrix Laboratory, Via Fratelli Cervi 93, 20090 Segrate, Milan, Italy. nicoletta.gagliano@unimi.it
Aldini
Giancarlo
G
Colombo
Graziano
G
Rossi
Ranieri
R
Colombo
Roberto
R
Gioia
Magda
M
Milzani
Aldo
A
Dalle-Donne
Isabella
I
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy*; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D000077185:Resveratrol; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors; D013267:Stilbenes / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D013267:Stilbenes; D012264:Ribonucleotide Reductases; D000077185:Resveratrol