title: Overexpression of Kif2a promotes the progression and metastasis of squamous cell carcinoma of the oral tongue.
abstract: The aim of this study was to examine the Kif2a expression and its role in tumor progression, invasion and metastasis in squamous cell carcinoma of the oral tongue (SCCOT). The study included 44 cases of primary tumor and the corresponding adjacent tissues, 20 cases of primary tumor with lymph node metastasis. Immunohistochemistry was used to observe the Kif2a expression and its correlation with clinicopathologic factors in oral tongue cancer. The immunohistochemistry showed that Kif2a expression was stronger in oral tongue cancer tissues than in paired adjacent tissues (P<0.01), and the higher expression of Kif2a was also significantly associated with lymph node metastasis (P<0.01), tumor clinical stage (P<0.01). In addition, in vitro results from transwell chamber assay showed that Tca8113 cells transfected with Kif2a-siRNA had a decreased migratory ability (P<0.01) compared to nonsense-siRNA-transfected cells. Therefore we speculate the overexpression of Kif2a might be involved in the progression, invasion and metastasis of SCCOT and Kif2a should be as a predictor for prognosis.
authors.affiliation: Department of Pathology, The School of Stomatology, Shandong University, Jinan, Shandong 250012, People's Republic of China.
authors.forename: Cheng-Qin
authors.initials: CQ
authors.lastname: Wang
authors.forename: Xun
authors.initials: X
authors.lastname: Qu
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Zhang
authors.forename: Cheng-Jun
authors.initials: CJ
authors.lastname: Zhou
authors.forename: Gui-Xiang
authors.initials: GX
authors.lastname: Liu
authors.forename: Zuo-Qing
authors.initials: ZQ
authors.lastname: Dong
authors.forename: Feng-Cai
authors.initials: FC
authors.lastname: Wei
authors.forename: Shan-Zhen
authors.initials: SZ
authors.lastname: Sun
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016547:Kinesins / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014062:Tongue Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C509805:KIF2A protein, human; D016547:Kinesins