title: Analysis of North American Rheumatoid Arthritis Consortium data using a penalized logistic regression approach.
abstract: We applied a penalized regression approach to single-nucleotide polymorphisms in regions on chromosomes 1, 6, and 9 of the North American Rheumatoid Arthritis Consortium data. Results were compared with a standard single-locus association test. Overall, the penalized regression approach did not appear to offer any advantage with respect to either detection or localization of disease-associated polymorphisms, compared with the single-locus approach.
authors.affiliation: Institute of Human Genetics, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ UK. pascal.croiseau@jouy.inra.fr.
authors.forename: Pascal
authors.initials: P
authors.lastname: Croiseau
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Cordell