Human immunodeficiency virus type-1 gag and host vesicular trafficking pathways.
The Gag protein of HIV-1 directs the particle assembly process. Gag recruits components of the cellular vesicular trafficking machinery in order to traverse the cytoplasm of the cell and reach the particle assembly site. The plasma membrane is the primary site of particle assembly in most cell types, while in macrophages an unusual intracellular membrane-bound compartment bearing markers of late endosomes and the plasma membrane is the predominant assembly site. Plasma membrane specificity of assembly may be directed by components of lipid rafts and the cytoplasmic leaflet component PI(4,5)P(2). Recent work has highlighted the role of adaptor protein complexes, protein sorting and recycling pathways, components of the multivesicular body, and cellular motor proteins in facilitating HIV assembly and budding. This review presents an overview of the relevant vesicular trafficking pathways and describes the individual components implicated in interactions with Gag.
Chu
Hin
H
Department of Pediatrics and Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Wang
Jaang-Jiun
JJ
Spearman
Paul
P
D033961:Adaptor Protein Complex 1 / Q000502:physiology; D033962:Adaptor Protein Complex 2 / Q000502:physiology; D001692:Biological Transport; D056827:Endosomal Sorting Complexes Required for Transport / Q000502:physiology; D015683:Gene Products, gag / Q000502:physiology*; D015497:HIV-1 / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D021962:Membrane Microdomains / Q000502:physiology; D057146:Multivesicular Bodies / Q000378:metabolism*; D019065:Virus Assembly; D020691:rab GTP-Binding Proteins / Q000502:physiology
D033961:Adaptor Protein Complex 1; D033962:Adaptor Protein Complex 2; D056827:Endosomal Sorting Complexes Required for Transport; D015683:Gene Products, gag; D020691:rab GTP-Binding Proteins