High-dose bone morphogenetic protein-induced ectopic abdomen bone growth.
BACKGROUND
Infuse [bone morphogenetic protein (BMP)] is increasingly used in spinal fusion surgery.


OBJECTIVE
The authors report a rare complication of BMP use.


METHODS
This is a case report.


METHODS
A 55-year-old male underwent a thoracic T8 to the pelvis fusion for degenerative lumbar disc disease and pseudarthrosis at another institution. The procedure involved an anterior and posterior approach with the use of multiple units of BMP.


METHODS
The patient presented to our institution with complaints of weight loss, pain, tenderness, and increasing solid growth in the left lower quadrant several months after his surgery. A computed tomography revealed ectopic bone growth in the retroperitoneal area and pelvis contiguous to the anterior lumbar exposure.


RESULTS
The anterior wound was re-explored, and a large sheet of ectopic bone was removed from the retroperitoneal space.


CONCLUSIONS
We report a rare case of extraspinal ectopic bone growth because of the use of multiple packages of BMP.
Deutsch
Harel
H
Rush University Medical Center, 1725 W. Harrison St. #970, Chicago, IL 60612, USA. harel_deutsch@rush.edu
D055396:Bone Morphogenetic Protein 2 / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000150:complications / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000209:etiology*; D011542:Pseudarthrosis / Q000150:complications / Q000601:surgery*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects; D012187:Retroperitoneal Space / Q000473:pathology* / Q000601:surgery; D013123:Spinal Fusion / Q000009:adverse effects*; D013904:Thoracic Vertebrae / Q000601:surgery; D016896:Treatment Outcome
D055396:Bone Morphogenetic Protein 2; D011994:Recombinant Proteins