Hyperlipidemia: a new therapeutic target for diabetic neuropathy.
Emerging data establish dyslipidemia as a significant contributor to the development of diabetic neuropathy. In this review, we discuss how separate metabolic imbalances, including hyperglycemia and hyperlipidemia, converge on mechanisms leading to oxidative stress in dorsal root ganglia (DRG) sensory neurons. We conclude with suggestions for novel therapeutic strategies to prevent or reverse diabetes-induced nerve degeneration.
Vincent
Andrea M
AM
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA. andreav@umich.edu
Hinder
Lucy M
LM
Pop-Busui
Rodica
R
Feldman
Eva L
EL
D000818:Animals; D003929:Diabetic Neuropathies / Q000503:physiopathology* / Q000628:therapy*; D005727:Ganglia, Spinal / Q000503:physiopathology; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology / Q000628:therapy; D006949:Hyperlipidemias / Q000503:physiopathology* / Q000628:therapy*; D018384:Oxidative Stress / Q000502:physiology; D011984:Sensory Receptor Cells / Q000502:physiology