Effects of levetiracetam and valproic acid monotherapy on sex-steroid hormones in prepubertal children--results from a pilot study.
The influence of levetiracetam (LEV) and valproic acid (VPA) monotherapy on sex-steroid hormone profile was investigated in thirty prepubertal children. VPA-treated children showed greatest androstendione concentrations when compared to LEV treated children (p=0.016) and to controls (p=0.011). All other reproductive endocrine hormones were similar among groups. In conclusion, LEV does not seem to induce changes in reproductive endocrine functions as well as clinically relevant endocrine side effects in prepubertal children.
Rauchenzauner
Markus
M
Department of Paediatrics IV, Division of Neuropediatrics, Medical University Innsbruck, Innsbruck, Austria.
Bitsche
Gabriele
G
Svalheim
Sigrid
S
Tauboll
Erik
E
Haberlandt
Edda
E
Wildt
Ludwig
L
Rostasy
Kevin
K
Luef
Gerhard
G
D000704:Analysis of Variance; D000927:Anticonvulsants / Q000009:adverse effects; D002648:Child; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006801:Humans; D000077287:Levetiracetam; D008297:Male; D010865:Pilot Projects; D010889:Piracetam / Q000009:adverse effects / Q000031:analogs & derivatives*; D012737:Sex Factors; D014635:Valproic Acid / Q000009:adverse effects*
D000927:Anticonvulsants; D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary; D000077287:Levetiracetam; D014635:Valproic Acid; D010889:Piracetam