Quantification of T-cell proliferation for individualizing immunosuppressive therapy for transplantation patients.
The serious side effects and complications related to the lifelong use of immunosuppressors in organ transplantation have fueled research into their possible minimization. Immunosuppressive therapy in organ transplantation is therefore tentatively moving from a phase of empirical administration toward individualized therapy. This process is highly dependent on the development of monitoring methods to detect individual immune states. The results of the studies by Kurata et al. support the usefulness of pharmacodynamic assays of lymphocyte function for the predictive monitoring of the effects of immunosuppressive drug therapy.
Ohdan
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Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan. hohdan@hiroshima-u.ac.jp
D049109:Cell Proliferation / Q000187:drug effects*; D016903:Drug Monitoring / Q000379:methods / Q000592:standards / Q000639:trends; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000276:immunology / Q000592:standards / Q000639:trends; D018655:Lymphocyte Count / Q000379:methods / Q000639:trends; D057285:Precision Medicine / Q000379:methods* / Q000639:trends; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology*
D007166:Immunosuppressive Agents