title: Effect of progesterone and pregnancy on the development of varicose veins.
abstract: The aim of this study was to investigate the contribution of progesterone in the development of primary varicose veins on lower limbs during pregnancy. In 50 primiparae with varicose veins, serum progesterone level was quantitatively determined in the 14th week of pregnancy and results were compared with those obtained in a control group of 25 primiparae without visible varicose veins. The mean serum progesterone concentration recorded in pregnant women with dilated veins (159.9+/-15.8 nmol/L) was significantly higher as compared with the control group (159.9+/-15.8 nmol/L vs. 40.4+/-1.6 nmol/L; P<0.0001). These findings supported the role of hormonal factor in the development of varicose veins in women.
authors.affiliation: University Department of Dermatology and Venereology, Rijeka University Hospital Center, Kresimirova 42, HR-51000 Rijeka, Croatia. maja.lenkovic@ri.t-com.hr
authors.forename: Maja
authors.initials: M
authors.lastname: Lenković
authors.forename: Leo
authors.initials: L
authors.lastname: Cabrijan
authors.forename: Franjo
authors.initials: F
authors.lastname: Gruber
authors.forename: Tanja
authors.initials: T
authors.lastname: Batinac
authors.forename: Teo
authors.initials: T
authors.lastname: Manestar-Blazić
authors.forename: Zrinka
authors.initials: Z
authors.lastname: Stanić Zgombić
authors.forename: Adalbert
authors.initials: A
authors.lastname: Stasić
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood* / Q000209:etiology*; D011374:Progesterone / Q000097:blood*; D014648:Varicose Veins / Q000097:blood* / Q000209:etiology*; D055815:Young Adult
chemical_list: D011374:Progesterone