title: Contribution of radiation hybrids to genome mapping in domestic animals.
abstract: Radiation hybrid mapping has emerged in the end of the 1990 s as a successful and complementary approach to map genomes, essentially because of its ability to bridge the gaps between genetic and clone-based physical maps, but also using comparative mapping approaches, between 'gene-rich' and 'gene-poor' maps. Since its early development in human, radiation hybrid mapping played a pivotal role in the process of mapping animal genomes, especially mammalian ones. We review here all the different steps involved in radiation hybrid mapping from the constitution of panels to the construction of maps. A description of its contribution to whole genome maps with a special emphasis on domestic animals will also be presented. Finally, current applications of radiation hybrid mapping in the context of whole genome assemblies will be described.
authors.affiliation: INRA, Laboratoire de Génétique Cellulaire and Biométrie et Intelligence Artificielle, Castanet-Tolosan, France. Thomas.faraut @ toulouse.inra.fr
authors.forename: T
authors.initials: T
authors.lastname: Faraut
authors.forename: S
authors.initials: S
authors.lastname: de Givry
authors.forename: C
authors.initials: C
authors.lastname: Hitte
authors.forename: Y
authors.initials: Y
authors.lastname: Lahbib-Mansais
authors.forename: M
authors.initials: M
authors.lastname: Morisson
authors.forename: D
authors.initials: D
authors.lastname: Milan
authors.forename: T
authors.initials: T
authors.lastname: Schiex
authors.forename: B
authors.initials: B
authors.lastname: Servin
authors.forename: A
authors.initials: A
authors.lastname: Vignal
authors.forename: F
authors.initials: F
authors.lastname: Galibert
authors.forename: M
authors.initials: M
authors.lastname: Yerle
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000235:genetics*; D002874:Chromosome Mapping; D005819:Genetic Markers; D016678:Genome; D005838:Genotype; D006822:Hybrid Cells / Q000528:radiation effects*
chemical_list: D005819:Genetic Markers