title: Borane-mediated asymmetric reduction of acetophenone by enantiopure aminonaphthols and aminoalcohols as catalytic source.
abstract: Practical, cheap, and stereoselective synthetic methods were applied to the preparation of novel 1-(aminoalkyl)naphthol and gamma-aminoalcohol tridentate ligands. The ligands obtained were conveniently applied with good results as catalytic sources in the borane-mediated enantioselective reduction of acetophenone with borane dimethylsulfide. Conformational analysis through molecular modeling allows the rationalization of observed stereochemical outcomes.
authors.affiliation: Department of Chemical Sciences, University of Camerino, Camerino, Italy. cristina.cimarelli@unicam.it
authors.forename: Cristina
authors.initials: C
authors.lastname: Cimarelli
authors.forename: Davide
authors.initials: D
authors.lastname: Fratoni
authors.forename: Gianni
authors.initials: G
authors.lastname: Palmieri