Hematogones: a review and update.
Our knowledge regarding the nature and function of 'hematogones' has evolved considerably, since the initial description more than 70 years ago. Once considered the 'mystery cells' of the bone marrow, major advances in immunology and flow cytometry have enabled us to better characterize these cells and recognize them as physiologic precursors of B-cells. In this review, we describe the morphologic and phenotypic characteristics and clinical relevance of hematogones, and report recent advances in our understanding and knowledge of these cells as they relate to physiologic and different pathologic conditions.
Sevilla
Deborah W
DW
Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA.
Colovai
Adriana I
AI
Emmons
Foxwell N
FN
Bhagat
Govind
G
Alobeid
Bachir
B
D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D001402:B-Lymphocytes / Q000166:cytology*; D001854:Bone Marrow Cells / Q000166:cytology*; D002454:Cell Differentiation; D019070:Cell Lineage; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D010641:Phenotype; D013234:Stem Cells / Q000166:cytology*
D015703:Antigens, CD