title: Insights into resistance against lincosamide antibiotics.
abstract: Bacteria utilize multiple strategies to circumvent antibiotics, producing broad specificity exporters or enzymes that catalyze the modification of either antibiotics or their targets. A report in this issue of Structure provides the structural and catalytic mechanisms of LinB, an adenylyltransferase of E. faecium that confers resistance to the lincosamide antibiotic clindamycin.
authors.affiliation: Department of Structural Biology, Hauptman-Woodward Medical Research Institute, State University of New York at Buffalo, Buffalo, NY, USA.
authors.forename: Jesse A
authors.initials: JA
authors.lastname: Sundlov
authors.affiliation: Department of Structural Biology, Hauptman-Woodward Medical Research Institute, State University of New York at Buffalo, Buffalo, NY, USA. Electronic address: gulick@hwi.buffalo.edu.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Gulick
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002981:Clindamycin / Q000737:chemistry / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics*; D016984:Enterococcus faecium / Q000187:drug effects*; D008958:Models, Molecular
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin