title: Uterine artery notch is associated with increased placental endothelial nitric oxide synthase and heat shock protein.
abstract: OBJECTIVE
  This study was undertaken to evaluate whether uterine artery notch is associated with placental expression of endothelial nitric oxide synthase (eNOS), Heat shock protein 70 (Hsp70), and Lectin-like oxidized low-density lipoprotein receptor (Lox) in pregnant women.
  
  
  METHODS
  Uterine artery Doppler was performed in 30 pregnant women divided into two groups with or without the presence of uterine artery notches. After delivery, placental expression of eNOS, Hsp70, and Lox were evaluated with western blot analysis.
  
  
  RESULTS
  Higher levels of placental eNOS (p = 0.02) and Hsp70 (p = 0.001) were expressed in the group with uterine artery notch compared with the group without uterine artery notch. There was no significant difference for placental Lox expression between group with uterine artery notch and without uterine artery notch (p = 0.17).
  
  
  CONCLUSIONS
  Our results suggest that uterine artery notch is associated with increased placental expression of eNOS and Hsp in pregnant women.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, Korea. kkyj@ewha.ac.kr
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Kim
authors.forename: Bo Eun
authors.initials: BE
authors.lastname: Lee
authors.forename: Hwa Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Hye Sook
authors.initials: HS
authors.lastname: Park
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Ha
authors.forename: Sung Chul
authors.initials: SC
authors.lastname: Jung
authors.forename: Myung Geol
authors.initials: MG
authors.lastname: Pang
mesh_terms: D015153:Blotting, Western; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology; D018840:HSP70 Heat-Shock Proteins / Q000032:analysis*; D006801:Humans; D052250:Nitric Oxide Synthase Type III / Q000032:analysis*; D010920:Placenta / Q000098:blood supply / Q000737:chemistry* / Q000201:enzymology; D011225:Pre-Eclampsia / Q000503:physiopathology; D011247:Pregnancy; D012189:Retrospective Studies; D051127:Scavenger Receptors, Class E / Q000032:analysis; D014463:Ultrasonography; D055988:Uterine Artery / Q000002:abnormalities / Q000000981:diagnostic imaging* / Q000503:physiopathology
chemical_list: D018840:HSP70 Heat-Shock Proteins; C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III