Clinical adenoviral gene therapy for prostate cancer.
Prostate cancer is at present the most common malignancy in men in the Western world. When localized to the prostate, this disease can be treated by curative therapy such as surgery and radiotherapy. However, a substantial number of patients experience a recurrence, resulting in spreading of tumor cells to other parts of the body. In this advanced stage of the disease only palliative treatment is available. Therefore, there is a clear clinical need for new treatment modalities that can, on the one hand, enhance the cure rate of primary therapy for localized prostate cancer and, on the other hand, improve the treatment of metastasized disease. Gene therapy is now being explored in the clinic as a treatment option for the various stages of prostate cancer. Current clinical experiences are based predominantly on trials with adenoviral vectors. As the first of a trilogy of reviews on the state of the art and future prospects of gene therapy in prostate cancer, this review focuses on the clinical experiences and progress of adenovirus-mediated gene therapy for this disease.
Schenk
Ellen
E
Department of Urology, Erasmus Medical Center , 3015 GD Rotterdam, The Netherlands.
Essand
Magnus
M
Bangma
Chris H
CH
Barber
Chris
C
Behr
Jean-Paul
JP
Briggs
Simon
S
Carlisle
Robert
R
Cheng
Wing-Shing
WS
Danielsson
Angelika
A
Dautzenberg
Iris J C
IJ
Dzojic
Helena
H
Erbacher
Patrick
P
Fisher
Kerry
K
Frazier
April
A
Georgopoulos
Lindsay J
LJ
Hoeben
Rob
R
Kochanek
Stefan
S
Koppers-Lalic
Daniela
D
Kraaij
Robert
R
Kreppel
Florian
F
Lindholm
Leif
L
Magnusson
Maria
M
Maitland
Norman
N
Neuberg
Patrick
P
Nilsson
Berith
B
Ogris
Manfred
M
Remy
Jean-Serge
JS
Scaife
Michelle
M
Schooten
Erik
E
Seymour
Len
L
Totterman
Thomas
T
Uil
Taco G
TG
Ulbrich
Karel
K
Veldhoven-Zweistra
Joke L M
JL
de Vrij
Jeroen
J
van Weerden
Wytske
W
Wagner
Ernst
E
Willemsen
Ralph
R
D000256:Adenoviridae / Q000235:genetics*; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D016896:Treatment Outcome