SAFB1's multiple functions in biological control-lots still to be done!
The examination of scaffold attachment factor B1 (SAFB1) and its multiple functions and tasks in cellular processes provides insight into its role in diseases, such as cancer. SAFB1 is a large multi-domain protein with well-described functions in transcriptional repression, and RNA splicing. It is ubiquitously expressed, and has been shown to be important in numerous cellular processes including cell growth, stress response, and apoptosis. SAFB1 is part of a protein family with at least two other family members, SAFB2 and the SAFB-like transcriptional modulator SLTM. The goal of this prospect article is to summarize known functions of SAFB1, and its roles in cellular processes, but also to speculate on less well described, novel attributes of SAFB1, such as a potential role in chromatin organization. This timely review shows aspects of SAFB1, which are proving to have a complexity far greater than was previously thought.
Garee
Jason P
JP
Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas, USA.
Oesterreich
Steffi
S
D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D002843:Chromatin / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D004268:DNA-Binding Proteins / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D036961:Matrix Attachment Region Binding Proteins / Q000737:chemistry / Q000502:physiology*; D051379:Mice; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D034521:Nuclear Matrix-Associated Proteins / Q000737:chemistry / Q000502:physiology*; D009928:Organ Specificity; D017434:Protein Structure, Tertiary; D016601:RNA-Binding Proteins / Q000502:physiology*; D011960:Receptors, Estrogen / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013312:Stress, Physiological / Q000502:physiology; D014158:Transcription, Genetic
D002843:Chromatin; D004268:DNA-Binding Proteins; D036961:Matrix Attachment Region Binding Proteins; D034521:Nuclear Matrix-Associated Proteins; D016601:RNA-Binding Proteins; D011960:Receptors, Estrogen; C109132:SAFB protein, human; C486369:SAFB2 protein, human; C500609:scaffold attachment factor B1, mouse