title: Evaluation of healing prosthetic materials polyester mesh resorbable film and collagen elastin matrix /polypropylene used in rabbits abdominal wall defects.
abstract: OBJECTIVE
  To compare polyester with absorbable layer prosthesis with collagen-elastin/polypropylene prosthesis in the repair of abdominal wall defects.
  
  
  METHODS
  The 16 studied rabbits were divided in groups A and B (euthanized on the 30th and 60th days, after the implant of the mesh). The animals underwent laparotomy and received a 2 cm wall 'defect' on each side of the Alba linea. The repair was made with the suture of a polyester mesh with absorbable film on the left side of the Alba Linea and with collagen-elastin/polypropylene mesh on the right side. Adherences were classified according to Nair Score and microscopic evaluation observing types I and III collagen formation and other immunohistochemical analyses.
  
  
  RESULTS
  There were no significant differences in adhesion formation. The collagen type I showed higher deposition in polyester with absorbable layer. In group B, the difference between the meshes was significant, with higher collagen III deposition in polyester with absorbable layer (60 masculine P.O.). About the metalloproteinases, the presence of MMP -1 and MMP-8 were about the same; the expression of MMP-13 increased near to the 60th day.
  
  
  CONCLUSIONS
  There is no significant difference between the two meshes in adhesion formation and immunohistochemical evaluation. The polyester mesh resorbable film presented a higher deposition of collagen.
authors.affiliation: Institute of Medical Research, Post-Graduate Program in Principles of Surgery, Curitiba Evangelic University Hospital -Evangelical School of Parana, Curitiba-PR, Brazil. ipem@evangelico.org.br
authors.forename: Danielle Duck
authors.initials: DD
authors.lastname: Schulz
authors.forename: Nicolau Gregori
authors.initials: NG
authors.lastname: Czeczko
authors.forename: Osvado
authors.initials: O
authors.lastname: Malafaia
authors.forename: Gustavo Justo
authors.initials: GJ
authors.lastname: Schulz
authors.forename: Leticia Elizabeth A
authors.initials: LE
authors.lastname: Czeczko
authors.forename: Larissa Santin
authors.initials: LS
authors.lastname: Garcia
authors.forename: Ulrich Andreas
authors.initials: UA
authors.lastname: Dietz
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D020341:Absorbable Implants; D000704:Analysis of Variance; D000818:Animals; D003094:Collagen / Q000032:analysis; D024042:Collagen Type I / Q000032:analysis; D024061:Collagen Type III / Q000032:analysis; D004549:Elastin; D005260:Female; D008422:Materials Testing; D053509:Matrix Metalloproteinase 13 / Q000032:analysis; D023421:Models, Animal; D011091:Polyesters; D011126:Polypropylenes; D011817:Rabbits; D018709:Statistics, Nonparametric; D013526:Surgical Mesh / Q000009:adverse effects* / Q000145:classification; D000267:Tissue Adhesions / Q000473:pathology; D014945:Wound Healing / Q000502:physiology*
chemical_list: D024042:Collagen Type I; D024061:Collagen Type III; D011091:Polyesters; D011126:Polypropylenes; D003094:Collagen; D004549:Elastin; D053509:Matrix Metalloproteinase 13