Emerging role for the cytoskeleton as an organizer and regulator of translation.
The cytoskeleton is an intricate and dynamic fibrous network that has an essential role in the generation and regulation of cell architecture and cellular mechanical properties. The cytoskeleton also evolved as a scaffold that supports diverse biochemical pathways. Recent evidence favours the hypothesis that the cytoskeleton participates in the spatial organization and regulation of translation, at both the global and local level, in a manner that is crucial for cellular growth, proliferation and function.
Kim
Seyun
S
The Solomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.
Coulombe
Pierre A
PA
D000818:Animals; D049109:Cell Proliferation; D003599:Cytoskeleton / Q000502:physiology*; D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D014176:Protein Biosynthesis