Recognition of additional roles for immunoglobulin domains in immune function.
Characterization of immune receptors found in phylogenetically disparate species at the genetic, structural and functional levels has provided unique insight into the evolutionary acquisition of immune function. The roles of variable- and intermediate-type immunoglobulin (Ig) domains in direct recognition of ligands and other functions are far wider than previously anticipated. Common mechanisms of multigene family diversification and expansion as well as unique adaptations that relate to function continue to provide unique insight into the numerous patterns, processes and complex interactions that regulate the host response to infectious challenge.
Cannon
John P
JP
University of South Florida, Department of Pediatrics, USF/ACH Children's Research Institute, 140 Seventh Avenue South, St. Petersburg, FL 33701, USA. jcannon@health.usf.edu
Dishaw
Larry J
LJ
Haire
Robert N
RN
Litman
Ronda T
RT
Ostrov
David A
DA
Litman
Gary W
GW
D056704:Adaptive Immunity; D000818:Animals; D000918:Antibody Specificity; D019143:Evolution, Molecular; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D005810:Multigene Family; D011971:Receptors, Immunologic / Q000276:immunology
D007136:Immunoglobulins; D011971:Receptors, Immunologic