Evaluating a marker's contribution to a nomogram: the GEMCaP example.
A postoperative nomogram developed in 1999 by Kattan et al. has been externally validated, but needs improvement. This tool predicts well but not perfectly. The Genomic Evaluators of Metastatic Prostate Cancer (GEMCaP) biomarkers hold promise for improving this tool; however, a larger data set that permits more involved analyses is needed.
Kattan
Michael W
MW
Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA. kattanm@ccf.org
D014408:Biomarkers, Tumor / Q000032:analysis*; D018450:Disease Progression; D006801:Humans; D008297:Male; D015233:Models, Statistical; D049451:Nomograms; D011184:Postoperative Period; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D012008:Recurrence; D018570:Risk Assessment
D014408:Biomarkers, Tumor