title: Trp64Arg polymorphism of the ADRB3 gene predicts hyperuricemia risk in a population from southern Spain.
abstract: OBJECTIVE
  To study the role of Trp64Arg polymorphism of the ADRB3 gene in the risk of developing hyperuricemia in 1051 subjects from southern Spain, with a followup of 6 years. The inclusion of plasma levels of uric acid as a diagnostic criterion to define the metabolic syndrome is under discussion. Genes responsible for insulin resistance could contribute to the development of hyperuricemia. Previous cross-sectional studies have suggested ADRB3 as a possible candidate gene in the development of hyperuricemia and insulin resistance.
  
  
  METHODS
  A prospective, population-based, cohort study of 1051 persons examined in 1997-98 and reassessed at a second examination 6 years later. The metabolic phenotype was assessed at baseline and again at the followup. Insulin resistance was measured by homeostasis model assessment. The Trp64Arg polymorphism of ADRB3 was detected by real-time polymerase chain reaction. Subjects were considered normouricemic if their serum uric acid levels were <or=7 mg/dl for men or <or= 6 mg/dl for women.
  
  
  RESULTS
  Carriers of the Arg64 allele who were normouricemic at baseline had a higher risk of developing hyperuricemia 6 years later (p = 0.017, OR 2.3, 95% CI 1.1-4.6). Multivariate logistic regression analysis showed that the OR of having hyperuricemia at the 6-year followup was significantly associated with the Arg64 allele, after adjusting for age, weight gain, baseline levels of triglycerides, serum uric acid, and insulin resistance (OR 3.1, 95% CI 1.3-7.1).
  
  
  CONCLUSIONS
  Trp64Arg polymorphism of the ADRB3 gene predicted the risk of developing hyperuricemia in this adult population.
authors.affiliation: Endocrinology and Nutrition Service, Hospital Carlos Haya, Malaga, Spain. sonsoles.morcillo.exts@juntadeandalucia.es
authors.forename: Sonsoles
authors.initials: S
authors.lastname: Morcillo
authors.forename: Gemma
authors.initials: G
authors.lastname: Rojo-Martínez
authors.forename: Gracia María
authors.initials: GM
authors.lastname: Martín-Núñez
authors.forename: Juan Miguel
authors.initials: JM
authors.lastname: Gómez-Zumaquero
authors.forename: Eduardo
authors.initials: E
authors.lastname: García-Fuentes
authors.forename: Marisol
authors.initials: M
authors.lastname: Ruiz de Adana
authors.forename: María
authors.initials: M
authors.lastname: de la Cruz Almaraz
authors.forename: Federico
authors.initials: F
authors.lastname: Soriguer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D016009:Chi-Square Distribution; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D033461:Hyperuricemia / Q000235:genetics*; D007333:Insulin Resistance / Q000235:genetics; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011446:Prospective Studies; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D012044:Regression Analysis; D012306:Risk; D013030:Spain; D014527:Uric Acid / Q000097:blood
chemical_list: D022702:Receptors, Adrenergic, beta-3; D014527:Uric Acid