[Interest of immunohistochemic markers (Ki67, HMB45, p53) in risk analysis of congenital naevi of little and middle size].
The risk to develop melanoma from small or medium size congenital naevus remain controversial. The main goal of the present study was to determine the interest of three immunohistochemical markers (Ki67, HMB45 and p53) in predicting malignant transformation of these congenital naevi and to see if a specific immunohistochemical profile of such transformed naevi can be identified. The markers (Ki67, HMB45 and p53) have been used retrospectively on sections of small or medium size congenital naevi (group NC, n = 15), of melanoma developed on small or medium size congenital naevi (group MNC, n = 15) and of melanoma developed on acquired naevi (group MNA, n = 15). The labelled cells have been counted in different cutaneous layers: junction, superficial dermal layer and deep dermal layer. No reactivity was observed for the three markers in group NC. The percentage of labelled cells was significantly different for the three markers between the group NC and the groups MNC and MNA. There was no difference between the groups MNC and MNA. In the groups MNC and MNA, a gradient in the percentage of labelled cells was observed between superficial and deep layers. These three markers do not differentiate melanoma developed from congenital naevi of small or medium size and melanoma developed from acquired naevi. Moreover, the results suggest that these three markers are useless in predicting the risk of malignant transformation of small or medium size congenital naevi.
Lejeune
C
C
Service de Dermatologie, Hôpital Erasme, Bruxelles.
Laporte
M
M
Musette
S
S
Petein
M
M
Heenen
M
M
D000951:Antigens, Neoplasm / Q000032:analysis*; D015415:Biomarkers; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D008545:Melanoma / Q000276:immunology / Q000473:pathology*; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000032:analysis*; D009508:Nevus, Pigmented / Q000150:complications / Q000151:congenital / Q000473:pathology; D012307:Risk Factors; D012878:Skin Neoplasms / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D000951:Antigens, Neoplasm; D015415:Biomarkers; D019394:Ki-67 Antigen; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D016159:Tumor Suppressor Protein p53