title: Catalytic enantioselective hydrogenation of N-alkoxycarbonyl hydrazones: a practical synthesis of chiral hydrazines.
abstract: An enantioselective hydrogenation of hydrazones catalyzed by Rh complexes (Rh-Josiphos or Rh-Taniaphos) has been developed. The protocol can be applied to hydrazones with three different protective groups (Boc, Cbz, and methoxycarbonyl), allowing for selective deprotection and further elaboration of the hydrazine products in the presence of other functional groups.
authors.affiliation: Department of Process Research, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065, USA. naoki_yoshikawa@merck.com
authors.forename: Naoki
authors.initials: N
authors.lastname: Yoshikawa
authors.forename: Lushi
authors.initials: L
authors.lastname: Tan
authors.forename: J Christopher
authors.initials: JC
authors.lastname: McWilliams
authors.forename: Deepa
authors.initials: D
authors.lastname: Ramasamy
authors.forename: Ruth
authors.initials: R
authors.lastname: Sheppard
mesh_terms: D002384:Catalysis; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry; D006865:Hydrogenation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006834:Hydrazines; D009942:Organometallic Compounds; D012238:Rhodium