Regulation of porcine endogenous retrovirus release by porcine and human tetherins.
The risk of transmission of porcine endogenous retrovirus (PERV) is one of the major safety issues in xenotransplantation. Human tetherin, recently described as an antiviral protein able to inhibit the release of enveloped viruses, and its porcine homologue were shown to inhibit PERV release from producer cells, establishing themselves as candidate molecules to suppress PERV production in porcine xenografts by animal engineering.
Mattiuzzo
Giada
G
Wohl Virion Centre, Division of Infection and Immunity, University College London, London, United Kingdom.
Ivol
Sabrina
S
Takeuchi
Yasuhiro
Y
D000595:Amino Acid Sequence; D000818:Animals; D030801:Animals, Genetically Modified; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D020077:Endogenous Retroviruses / Q000235:genetics / Q000378:metabolism*; D058851:GPI-Linked Proteins; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D013552:Swine; D013553:Swine Diseases / Q000635:transmission / Q000821:virology; D014183:Transplantation, Heterologous / Q000009:adverse effects; D015047:Zoonoses / Q000821:virology; D000074010:Bone Marrow Stromal Antigen 2
D015703:Antigens, CD; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; D020033:Protein Isoforms; C094572:BST2 protein, human; D000074010:Bone Marrow Stromal Antigen 2