Immunological identification of the mouse H4 histamine receptor on spinal cord motor neurons using a novel anti-mouse H4R antibody.
In this report, we describe the development of the first anti-mouse H(4) receptor antibody. Utilising this new immunological probe, new evidence is provided for oligomeric mH(4)Rs and the presence of H(4) receptors on a subpopulation of murine motor neurons. This expands the cell types where the H(4) receptor is expressed in the mammalian CNS.
Lethbridge
N L
NL
Centre for Integrative Neuroscience, School of Biological and Biomedical Sciences, University of Durham, Durham, UK.
Chazot
P L
PL
D000595:Amino Acid Sequence; D000818:Animals; D019138:Antibodies, Blocking / Q000494:pharmacology*; D000918:Antibody Specificity; D015153:Blotting, Western; D007150:Immunohistochemistry; D051379:Mice; D008969:Molecular Sequence Data; D009046:Motor Neurons / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000276:immunology / Q000378:metabolism*; D011968:Receptors, Histamine / Q000276:immunology / Q000378:metabolism*; D000074040:Receptors, Histamine H4; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism*; D014162:Transfection
D019138:Antibodies, Blocking; C498829:Hrh4 protein, mouse; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4