[Glyoxal: a possible polyvalent substitute for formaldehyde in pathology?].
The quest for formaldehyde substitutes is motivated by two fundamental developments: the OSHA regulation standard declaring it hazardous and advocating its substitution with less dangerous chemicals and the fact that formalin is a poor preserver of nucleic acids. Among the non-alcoholic formalin substitute, glyoxal has been hailed as the best alternative. In this work, we showed that glyoxal-containing fixatives are not plausible polyvalent substitution options.
Marcon
Nathalie
N
Equipe d'accueil signalisation et génomique fonctionnelle en recherche translationnelle oncologique, service d'anatomie et cytologie pathologiques, hôpitaux de Brabois, CHU de Nancy, université de Nancy, 5, allée du Morvan, 54511 Vandoeuvre-lès-Nancy, France. n.marcon@chu-nancy.fr
Bressenot
Aude
A
Montagne
Karine
K
Bastien
Claire
C
Champigneulle
Jacqueline
J
Monhoven
Nathalie
N
Albuisson
Eliane
E
Plénat
François
F
D004202:Disinfectants; D005404:Fixatives; D005557:Formaldehyde / Q000031:analogs & derivatives*; D006037:Glyoxal / Q000737:chemistry*; D009696:Nucleic Acids / Q000737:chemistry; D011310:Preservatives, Pharmaceutical / Q000592:standards*; D016707:Tissue Fixation / Q000592:standards; D014481:United States; D014489:United States Occupational Safety and Health Administration / Q000331:legislation & jurisprudence
D004202:Disinfectants; D005404:Fixatives; D009696:Nucleic Acids; D011310:Preservatives, Pharmaceutical; D005557:Formaldehyde; D006037:Glyoxal