Regulatory natural killer cells: new players in the IL-10 anti-inflammatory response.
Natural Killer (NK) cells boost immune defense via their cytolytic activity and their capacity to produce interferon-gamma. Now Perona-Wright et al. (2009), in this issue of Cell Host & Microbe, show that NK cells can also dampen immune responses to diverse pathogens via secretion of the anti-inflammatory cytokine interleukin-10. Remarkably, this immunosuppressive activity only occurs during systemic infections.
Vivier
Eric
E
Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Marseille 13288, France. vivier@ciml.univ-mrs.fr
Ugolini
Sophie
S
D000818:Animals; D002478:Cells, Cultured; D015870:Gene Expression; D006801:Humans; D007239:Infections / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology; D016753:Interleukin-10 / Q000276:immunology*; D018664:Interleukin-12 / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D008089:Listeria monocytogenes / Q000276:immunology; D051379:Mice; D014122:Toxoplasma / Q000276:immunology; D015010:Yersinia pestis / Q000276:immunology
D016753:Interleukin-10; D018664:Interleukin-12