Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents.
This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.
Li
Wen-Shan
WS
Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan.
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Shivaji V
SV
Wang
Chie-Hong
CH
Jen
Ya Ching
YC
Yao
Ching-Fa
CF
Wang
Tein-Fu
TF
Hung
Chin-Chun
CC
Jao
Shu-Chuan
SC
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003958:Diamide / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000627:therapeutic use; D005663:Furans / Q000138:chemical synthesis* / Q000627:therapeutic use; D006801:Humans; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D005663:Furans; D003958:Diamide