title: Total synthesis of the anti-apoptotic agents iso- and bongkrekic acids.
abstract: The first convergent total synthesis of isobongkrekic acid is reported involving three different stereospecific palladium cross-couplings for the formation of the diene units. Access to bongkrekic acid by this route is also demonstrated. These syntheses involve the formation of several potentially general building blocks.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
authors.forename: Antoine
authors.initials: A
authors.lastname: Francais
authors.forename: Antonio
authors.initials: A
authors.lastname: Leyva
authors.forename: Gorka
authors.initials: G
authors.lastname: Etxebarria-Jardi
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D001865:Bongkrekic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D001865:Bongkrekic Acid