Synthesis of 3-hydroxyoxindoles by Pd-catalysed intramolecular nucleophilic addition of aryl halides to alpha-ketoamides.
Pd/PtBu(3)-catalysed intramolecular nucleophilic addition of aryl halides to alpha-ketoamides in the presence of nBuOH and base has been realized with high yields, providing a new, direct, and efficient synthetic strategy to obtain 3-hydroxyoxindoles.
Jia
Yi-Xia
YX
Department of Organic Chemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland.
Katayev
Dmitry
D
Kündig
E Peter
EP