Prediction of potential protein post-translational modifications of the thioredoxin-1 molecule.
Thioredoxin-1 is a 12-kDa protein with anti-oxidative, antiapoptotic and pro-proliferative functions, and it offers protection against cardiac hypertrophy. It has been found that the physiological regulation of thioredoxin-1 requires post-translational modifications and this may be an important step in the pathophysiology of cardiomyopathy. In this study, the potential protein post-translational modifications in thioredoxin-1 were determined with a standard bioinformatics technique, FindMod. No potential protein posttranslational modifications were found, which may indicate that they are not an important step in the pathophysiology of cardiomyopathy.
Wiwanitkit
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Wiwanitkit House, Bangkhae, Bangkok Thailand. wviroj@yahoo.com
D009202:Cardiomyopathies / Q000503:physiopathology*; D019295:Computational Biology; D006801:Humans; D018384:Oxidative Stress; D011499:Protein Processing, Post-Translational; D013879:Thioredoxins / Q000378:metabolism*
D013879:Thioredoxins