title: Autoimmune focal encephalitis shows marked hypermetabolism on positron emission tomography.
abstract: A 22-month-old toddler presented with involuntary movements, hemiparesis, and behavioral changes. Magnetic resonance imaging showed no abnormality, but positron emission tomography (PET) showed focal hypermetabolism. By immunohistochemical technique with the patient's sera in control brain sections, autoantibodies recognizing the same areas as found by PET scanning were identified and disappeared after intravenous immunoglobulin therapy. PET scanning may be useful in the diagnosis of autoimmune encephalitis.
authors.affiliation: Department of Pediatrics, Juntendo Nerima Hospital, Tokyo, Japan. m-seki@med-juntendo.ac.jp
authors.forename: Mariko
authors.initials: M
authors.lastname: Sekigawa
authors.forename: Akihisa
authors.initials: A
authors.lastname: Okumura
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Niijima
authors.forename: Masaharu
authors.initials: M
authors.lastname: Hayashi
authors.forename: Kyoko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D004660:Encephalitis / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use; D007150:Immunohistochemistry; D007155:Immunologic Factors / Q000008:administration & dosage / Q000627:therapeutic use; D007223:Infant; D008279:Magnetic Resonance Imaging; D049268:Positron-Emission Tomography
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors