Low body adiposity and high leptinemia in breast-fed infants born small-for-gestational-age.
Breast-fed infants born small-for-gestational-age (SGA) (n = 28) were found to develop lower adiposity across early infancy, when compared with appropriate-for-gestational age infants (n = 46). The SGA infants were also found to have 2-fold higher (P < .001) levels of circulating leptin at 4 months. This paradoxical hyperleptinemia in early infancy may contribute to a program that produces a process from fetal underweight to adult overweight.
Ibáñez
Lourdes
L
Endocrinology Unit, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain. libanez@hsjdbcn.org
Sebastiani
Giorgia
G
Diaz
Marta
M
Gómez-Roig
Maria Dolores
MD
Lopez-Bermejo
Abel
A
de Zegher
Francis
F
D050154:Adiposity / Q000502:physiology*; D001823:Body Composition; D001942:Breast Feeding; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000502:physiology*; D020738:Leptin / Q000097:blood*; D008297:Male
D020738:Leptin