title: [Diagnostic value of double contrast-enhanced ultrasonography in preoperative staging of gastric cancer].
abstract: OBJECTIVE
  To evaluate the clinical value of double contrast-enhanced ultrasonography using oral and intravenous contrast agents in preoperative staging of gastric cancer.
  
  
  METHODS
  Sixty-two patients with biopsy-proven gastric cancer were enrolled into this study, and were examined by double contrast-enhanced gastric ultrasonography preoperatively. The results were compared with postoperative pathologic findings.
  
  
  RESULTS
  The accuracy of oral contrast-enhanced gastric ultrasonography and double contrast-enhanced ultrasonography in determining the T stage of gastric cancer was 72.9% (T1: 66.7%, T2: 60.0%, T3: 76.9%, T4: 71.4%) and 88.1% (T1: 66.7%, T2: 80.0%, T3: 89.7%, T4: 100%), respectively, with a statistically significant difference between the two methods (P = 0.036). The sensitivity, specificity, accuracy and Youden index of oral contrast-enhanced gastric ultrasonography and double contrast-enhanced ultrasonography in assessment of lymph node metastasis were 74.5%, 66.7%, 72.9%, and 0.41 versus 89.4%, 75.0%, 86.4%, 0.76, respectively. No significant difference in the accuracy of assessment for lymph node metastasis was observed (P > 0.05).
  
  
  CONCLUSIONS
  Double contrast-enhanced ultrasonography is useful for preoperative staging of gastric cancer, especially for T staging.
authors.affiliation: Department of General Surgery, Lin'an People's Hospital, Lin'an, Zhejiang, China.
authors.forename: Cheng-long
authors.initials: CL
authors.lastname: Wang
authors.forename: Yong-ming
authors.initials: YM
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Cui
authors.forename: Hong
authors.initials: H
authors.lastname: Ouyang
authors.forename: Zhe-min
authors.initials: ZM
authors.lastname: Wang
authors.forename: Huai-song
authors.initials: HS
authors.lastname: Ye
authors.forename: Hua-juan
authors.initials: HJ
authors.lastname: Ruan
authors.forename: Zhi-qiang
authors.initials: ZQ
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D019160:Endosonography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D011300:Preoperative Care; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D013459:Sulfur Hexafluoride
chemical_list: D003287:Contrast Media; D013459:Sulfur Hexafluoride