title: Clinico-radiological correlation in childhood hypopituitarism.
abstract: Non-tumor etiology constitutes a major group of childhood hypopituitarism. Magnetic resonance imaging has enormously complimented hormonal assessment in these patients. We describe clinico-radiological correlates in thirty-one children (23 boys), aged 1-17 years with a peak GH (growth hormone) levels <7 ng/mL after pharmacological stimuli. Hypoplastic pituitary gland was the most frequent abnormality in children with isolated growth hormone deficiency (IGHD) as compared to stalk abnormalities in children with multiple pituitary hormone deficiencies. MRI tetrad (hypoplastic/absent pituitary, hypoplastic stalk, absent/ectopic posterior pituitary bright spot and empty sella) was more prevalent in IGHD. MRI abnormalities correlated with the severity of growth hormone deficiency.
authors.affiliation: Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India.
authors.forename: Pinaki
authors.initials: P
authors.lastname: Dutta
authors.forename: Anil
authors.initials: A
authors.lastname: Bhansali
authors.forename: Paramjeet
authors.initials: P
authors.lastname: Singh
authors.forename: Rajesh
authors.initials: R
authors.lastname: Rajput
authors.forename: Sanjay
authors.initials: S
authors.lastname: Bhadada
mesh_terms: D000293:Adolescent; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D000013:Congenital Abnormalities; D005260:Female; D030342:Genetic Diseases, Inborn; D013006:Growth Hormone / Q000097:blood / Q000172:deficiency; D006801:Humans; D007018:Hypopituitarism / Q000097:blood / Q000473:pathology; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D010902:Pituitary Gland / Q000002:abnormalities*
chemical_list: D013006:Growth Hormone