Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor inducible-14 might regulate the effects of interleukin 18 and 15 in the human endometrium.
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) could play a role in the regulation of interleukin (IL)-15 and IL-18, cytokines crucial for angiogenesis and uterine natural killer (uNK) cell recruitment during embryo implantation. We therefore confirmed the endometrial presence of TWEAK/fibroblast growth factor inducible-14 (Fn-14) and documented simultaneously the cytotoxic KIR receptor (NKp46) of uNK cells in the human endometrium while TWEAK, Fn-14, IL-15, and IL-18 mRNA were quantified by real-time polymerase chain reaction in relation to the recruitment of CD56+ cells among fertile control women and patients who had failed to implant after assisted reproduction treatment.
Petitbarat
Marie
M
INSERM, U 782, Equipe Cytokines et Dialogue Cytokinique Mère Conceptus, Université Paris-Sud, UMR-S0782, and Hôpital Antoine Béclère, Clamart, France.
Serazin
Valérie
V
Dubanchet
Sylvie
S
Wayner
Robert
R
de Mazancourt
Philippe
P
Chaouat
Gérard
G
Lédée
Nathalie
N
D016022:Case-Control Studies; D002452:Cell Count; D000074049:Cytokine TWEAK; D004717:Endometrium / Q000187:drug effects / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007247:Infertility, Female / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D019409:Interleukin-15 / Q000235:genetics* / Q000378:metabolism / Q000494:pharmacology; D020382:Interleukin-18 / Q000235:genetics* / Q000378:metabolism / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000166:cytology / Q000378:metabolism; D011247:Pregnancy; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000074050:TWEAK Receptor; D048069:Tumor Necrosis Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D000074049:Cytokine TWEAK; D019409:Interleukin-15; D020382:Interleukin-18; D018124:Receptors, Tumor Necrosis Factor; C000613297:TNFRSF12A protein, human; C109743:TNFSF12 protein, human; D000074050:TWEAK Receptor; D048069:Tumor Necrosis Factors