title: Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis.
abstract: The iterative polyketide synthases from the biosynthetic pathways of three enediyne natural products were examined. The results established the all-trans conjugated pentadecaheptanene as the only major product shared by the PKSs. The experiments further revealed some intrinsic differences among the PKSs by demonstrating the formation of different by-products.
authors.affiliation: School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.
authors.forename: Huihua
authors.initials: H
authors.lastname: Sun
authors.forename: Rong
authors.initials: R
authors.lastname: Kong
authors.forename: Di
authors.initials: D
authors.lastname: Zhu
authors.forename: Min
authors.initials: M
authors.lastname: Lu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ji
authors.forename: Chong Wai
authors.initials: CW
authors.lastname: Liew
authors.forename: Julien
authors.initials: J
authors.lastname: Lescar
authors.forename: Guofu
authors.initials: G
authors.lastname: Zhong
authors.forename: Zhao-Xun
authors.initials: ZX
authors.lastname: Liang
mesh_terms: D001688:Biological Products / Q000096:biosynthesis / Q000737:chemistry; D053281:Enediynes / Q000737:chemistry* / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology*; D015394:Molecular Structure; D048630:Polyketide Synthases / Q000378:metabolism*
chemical_list: D001688:Biological Products; D053281:Enediynes; D048630:Polyketide Synthases