Organocatalytic asymmetric Povarov reactions with 2- and 3-vinylindoles.
The asymmetric Povarov reaction of N-arylimines with 2- and 3-vinylindoles has been developed using a chiral phosphoric acid ((S)-TRIP) as catalyst. The peculiar reactivity of vinylindoles allowed also the disclosure of a Povarov Friedel-Crafts sequence, and the trapping of the reaction intermediate with nucleophilic species, thus providing a versatile platform for the preparation of highly enantioenriched indole derivatives.
Bergonzini
Giulia
G
Department of Organic Chemistry A. Mangini, University of Bologna, V. Risorgimento 4, 40136 Bologna, Italy.
Gramigna
Lucia
L
Mazzanti
Andrea
A
Fochi
Mariafrancesca
M
Bernardi
Luca
L
Ricci
Alfredo
A