title: CTX biochemical marker of bone metabolism. Is it a reliable predictor of bisphosphonate-associated osteonecrosis of the jaws after surgery? Part I: biological concepts with a review of the literature.
abstract: Biochemical markers of bone metabolism have been used in medicine to evaluate and provide treatment to patients with metabolic bone diseases, such as osteoporosis. Serum cross-linked C-telopeptide of type I collagen is a marker of osteoclast activity and is used to assess the level of bone resorption. Recently, in oral and maxillofacial surgery, it was proposed that the levels of serum cross-linked C-telopeptide of type I collagen may predict the subsequent risk of developing osteonecrosis of the jaws after oral surgery procedures for patients taking oral bisphosphonates. The astute clinician must critically review the scientific literature and must decide if biochemical markers of bone resorption are of benefit in managing the oral surgery patient on bisphosphonates.
authors.affiliation: Oral, Maxillofacial and Reconstructive Surgery, Private Practice, Aiea, HI, USA. CLee555294@aol.com
authors.forename: Cameron Y S
authors.initials: CY
authors.lastname: Lee
authors.forename: Jon B
authors.initials: JB
authors.lastname: Suzuki
mesh_terms: D015415:Biomarkers / Q000097:blood; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D016723:Bone Remodeling / Q000187:drug effects / Q000502:physiology; D001862:Bone Resorption / Q000097:blood; D024042:Collagen Type I / Q000097:blood*; D004164:Diphosphonates / Q000009:adverse effects*; D005544:Forecasting; D006801:Humans; D007571:Jaw Diseases / Q000097:blood / Q000139:chemically induced*; D019647:Oral Surgical Procedures / Q000009:adverse effects; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism; D010020:Osteonecrosis / Q000097:blood / Q000139:chemically induced*; D010455:Peptides / Q000097:blood*
chemical_list: D015415:Biomarkers; D050071:Bone Density Conservation Agents; D024042:Collagen Type I; D004164:Diphosphonates; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide