title: Hemoglobin bis-tetramers via cooperative azide-alkyne coupling.
abstract: Cross-linked hemoglobin-azides react with a bis-alkyne to form a bis-tetramer through sequential "click" reactions where the second step is promoted by the first.
authors.affiliation: Davenport Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario, Canada M5S 3H6.
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Foot
authors.forename: Francine E
authors.initials: FE
authors.lastname: Lui
authors.forename: Ronald
authors.initials: R
authors.lastname: Kluger
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006454:Hemoglobins / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D055503:Protein Multimerization; D055550:Protein Stability; D012995:Solubility
chemical_list: D000480:Alkynes; D001386:Azides; D003432:Cross-Linking Reagents; D006454:Hemoglobins