Articular cartilage compression: how microstructural response influences pore pressure in relation to matrix health.
Our research investigated the influence of degeneration on both the pore-pressure development and microstructural response of cartilage during indentation with a flat-porous-indenter. Experiments were conducted to link the mechanical and structural responses of normal and degenerate articular cartilage. We found that from the instant of loading the degenerate matrix generated a higher peak hydrostatic excess pore pressure in a shorter period of time than the normal matrix. Following the attainment of this peak value the pore pressure in both tissue groups then gradually decayed toward zero over time, thus demonstrating a classical consolidation response. The microstructural analysis provided a unique insight into the influence of degeneration on the mechanisms of internal stress-sharing within the loaded matrix. Both disruption of the articular surface and general matrix destructuring results in an altered deformation field in both the directly loaded and nondirectly loaded regions. It is argued that the higher levels of matrix shear combined with less of the applied load being redirected into the wider cartilage continuum accounts for the elevated levels of peak hydrostatic pore pressure generated in the degenerate matrix.
Fick
James M
JM
Biomaterials Laboratory, Department of Chemical and Materials Engineering, University of Auckland, Auckland, New Zealand.
Thambyah
Ashvin
A
Broom
Neil D
ND
D000818:Animals; D002358:Cartilage, Articular / Q000033:anatomy & histology / Q000502:physiology*; D002417:Cattle; D005109:Extracellular Matrix / Q000502:physiology*; D006874:Hydrostatic Pressure; D010329:Patella; D013264:Stifle / Q000502:physiology*; D013314:Stress, Mechanical; D016474:Weight-Bearing