title: Terahertz absorption spectra of original and generic ceftazidime.
abstract: The absorption spectra of ceftazidime and its generic versions (Modacin, Mosyl, and Mobenzocin) have been measured by terahertz time domain spectroscopy (THz-TDS). Differences in the THz absorption were observed between the original and generic versions. The results show small, but significant differences in the states of ceftazidime hydrate between the original and generic versions. THz-TDS can be used to evaluate the stability of medicines as well as to control their quality.
authors.affiliation: Nagahama Institute of Bio-science and Technology, 1266 Tamura, Nagahama, Shiga 526-0829, Japan. m_kawase@nagahama-i-bio.ac.jp
authors.forename: Masaya
authors.initials: M
authors.lastname: Kawase
authors.forename: Tadashi
authors.initials: T
authors.lastname: Saito
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ogawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Uejima
authors.forename: Yasutoshi
authors.initials: Y
authors.lastname: Hatsuda
authors.forename: Sonoyo
authors.initials: S
authors.lastname: Kawanishi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Hirotani
authors.forename: Michiaki
authors.initials: M
authors.lastname: Myotoku
authors.forename: Kenji
authors.initials: K
authors.lastname: Ikeda
authors.forename: Keisuke
authors.initials: K
authors.lastname: Takano
authors.forename: Masanori
authors.initials: M
authors.lastname: Hangyo
authors.forename: Kohji
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tani
mesh_terms: D000042:Absorption; D002442:Ceftazidime / Q000737:chemistry*; D004355:Drug Stability; D016568:Drugs, Generic / Q000737:chemistry*; D006358:Hot Temperature; D013057:Spectrum Analysis
chemical_list: D016568:Drugs, Generic; D002442:Ceftazidime