title: The association of increasing body mass index and kidney stone disease.
abstract: OBJECTIVE
  Previous epidemiological works have reported that obesity is a risk factor for kidney stone disease. However, the effect of increasing degrees of obesity on stone formation has yet to be defined. To address this question we examined how an increasing body mass index affects the risk of kidney stone disease.
  
  
  METHODS
  We evaluated claims from a 5-year period (2002 to 2006) in a national private insurance database to identify subjects diagnosed with or treated for kidney stones. From a data set of 95,598 patients, subjects were identified by ICD-9 or CPT codes specific to kidney stone disease. Descriptive analyses were performed and odds ratios were calculated.
  
  
  RESULTS
  Gender distribution of the 3,257 stone formers was 42.9% male and 57.1% female. Obesity (body mass index greater than 30 kg/m(2)) was associated with a significantly greater likelihood of being diagnosed with a kidney stone. However, when obese patients were stratified by body mass index there were no significant differences in the likelihood of a kidney stone diagnosis, suggesting a stabilization of risk once body mass index increased above 30 kg/m(2). The association of body mass index and a stone removal procedure was significant only for men and women with a body mass index between 30 and 45 kg/m(2) relative to a body mass index less than 25 kg/m(2) (p <0.001).
  
  
  CONCLUSIONS
  An obese body mass index is associated with an increased risk of kidney stone disease. However, the magnitude of this risk appears to be stable in the morbidly obese population. Once body mass index is greater than 30 kg/m(2), further increases do not appear to significantly increase the risk of stone disease.
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
authors.forename: Michelle J
authors.initials: MJ
authors.lastname: Semins
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Shore
authors.forename: Martin A
authors.initials: MA
authors.lastname: Makary
authors.forename: Thomas
authors.initials: T
authors.lastname: Magnuson
authors.forename: Roger
authors.initials: R
authors.lastname: Johns
authors.forename: Brian R
authors.initials: BR
authors.lastname: Matlaga
mesh_terms: D015992:Body Mass Index; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors