title: Variable optical activation of human cone photoreceptors visualized using a short coherence light source.
abstract: It has been shown that after a visible stimulus, optical oscillations of nearly all cone photoreceptors can be observed using long coherence length light and in a few cones using short coherence length light. Here, we show that after exposure to a visible stimulus, a short coherence length imaging source reveals light-evoked oscillation signals in a large number of cones. More than 80% of cones in a given retinal area are activated (modulation in the reflectance signal) after stimulation, and the pattern of their activation can be subjectively classified into one of four categories. The application of light-evoked signal detection techniques for in vivo retinal imaging may prove useful for assessing the functional status of cones in normal and diseased retinae.
authors.affiliation: Department of Ophthalmology, Medical College of Wisconsin, 925 North 87th Street,Milwaukee, Wisconsin 53226, USA. jrha@mcw.edu
authors.forename: Jungtae
authors.initials: J
authors.lastname: Rha
authors.forename: Brett
authors.initials: B
authors.lastname: Schroeder
authors.forename: Pooja
authors.initials: P
authors.lastname: Godara
authors.forename: Joseph
authors.initials: J
authors.lastname: Carroll
mesh_terms: D004307:Dose-Response Relationship, Radiation; D005074:Evoked Potentials, Visual / Q000502:physiology / Q000528:radiation effects; D006801:Humans; D008027:Light; D008029:Lighting / Q000379:methods*; D010775:Photic Stimulation / Q000379:methods*; D011829:Radiation Dosage; D017949:Retinal Cone Photoreceptor Cells / Q000502:physiology* / Q000528:radiation effects