Control of protein adsorption onto core-shell tubular and vesicular structures of diphenylalanine/parylene.
The self-assembly of peptides, specifically dipeptides, offers numerous advantages for biological applications. We describe an easy, versatile method of fabricating different types of zwitterionic Phe-Phe dipeptide structures (i.e., tubes and vesicles) through solvent-mediated assembly. The stability of the dipeptide structures is increased by thin polymer coatings of poly(chloro-p-xylylene), a PPX film. We also investigated protein adsorption onto PPX-coated peptide tubes and vesicles by varying the thickness of the polymer film.
Demirel
Gökhan
G
Materials Research Institute, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Malvadkar
Niranjan
N
Demirel
Melik C
MC
D000327:Adsorption; D000818:Animals; D002417:Cattle; D004151:Dipeptides; D004337:Drug Carriers / Q000737:chemistry; D018014:Gene Transfer Techniques; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D014835:Volatilization; D014992:Xylenes / Q000737:chemistry*
D004151:Dipeptides; D004337:Drug Carriers; D011108:Polymers; D011506:Proteins; D012997:Solvents; D014992:Xylenes; C011055:parylene; C026650:phenylalanylphenylalanine; D012710:Serum Albumin, Bovine; D010649:Phenylalanine