Skeletal muscle injury versus adaptation with aging: novel insights on perplexing paradigms.
A growing body of data supports a view that skeletal muscle's response after mechanical loading does not always result in the classically reported "injury response." Furthermore, current evidence supports a model of muscle adaptation and/or maladaptation, distinct from overt injury, in which myofiber degeneration and inflammation do not contribute as significantly as once reported even in aged populations.
Baker
Brent A
BA
National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States.
Cutlip
Robert G
RG
D000222:Adaptation, Physiological; D000375:Aging / Q000502:physiology*; D000818:Animals; D006801:Humans; D023421:Models, Animal; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000293:injuries / Q000502:physiology*; D016474:Weight-Bearing