title: Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer.
authors.affiliation: Incyte Corporation, Experimental Station, E336/131A, Route 141 and Henry Clay Road, Wilmington, Delaware 19880, USA. acombs@incyte.com
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Combs
mesh_terms: D018360:Crystallography, X-Ray; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000201:enzymology; D055808:Drug Discovery / Q000379:methods / Q000639:trends; D004345:Drug Industry / Q000379:methods / Q000639:trends; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D009765:Obesity / Q000188:drug therapy* / Q000201:enzymology; D017434:Protein Structure, Tertiary; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors* / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1