Antibodies and DNA photoproducts: applications, milestones and reference guide.
Polyclonal and monoclonal antibodies recognizing the primary DNA photoproducts induced by ultraviolet radiation (UVR) have proven to be essential tools in the study of photochemical and photobiological phenomena. As specific "DNA damage binding proteins" these reagents have been used to develop a diverse array of technical procedures applied to a plethora of important problems in DNA photochemistry and the biological effects of UVR at the molecular, developmental, organism and population levels. This survey attempts to cover this science from an historical perspective and to reveal the great breadth of discovery and contribution associated with the development and application of DNA damage antibodies to the current body of science.
Mitchell
David
D
Science Park/Research Division, Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, USA. dmitchel@mdanderson.org
Brooks
Becky
B
D000906:Antibodies / Q000276:immunology*; D004247:DNA / Q000528:radiation effects; D004249:DNA Damage / Q000276:immunology*; D015336:Molecular Probe Techniques; D055668:Photochemical Processes; D014466:Ultraviolet Rays
D000906:Antibodies; D004247:DNA