Preparation of highly substituted tetrahydropyrans via a metal assisted dipolar cycloaddition reaction.
A range of highly substituted tetrahydropyrans have been prepared by reaction of a donor-acceptor cyclobutane, where the donor is a metal-alkyne complex, with an aldehyde under Lewis acid conditions.
Allart
Eric A
EA
Department of Chemistry, Loughborough University, Loughborough, Leicestershire, UK LE11 3TU.
Christie
Steven D R
SD
Pritchard
Gareth J
GJ
Elsegood
Mark R J
MR