title: Design, multicomponent synthesis, and bioactivities of novel neonicotinoid analogues with 1,4-dihydropyridine scaffold.
abstract: Novel neonicotinoid analogues bearing a 1,4-dihydropridine scaffold were designed and synthesized by multicomponent reactions (MCRs) to enhance pi-pi stacking. The synthesized compounds were identified by (1)H NMR, (13)C NMR, high-resolution mass spectroscopy, and elemental analysis. Bioassay tests showed that some of them exhibited high insecticidal activities against pea aphid ( Aphis craccivora ).
authors.affiliation: Shanghai Key Laboratory of Chemistry Biology, Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, Shanghai, China 200237.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Zhang
authors.forename: Xiaobao
authors.initials: X
authors.lastname: Yang
authors.forename: Weidong
authors.initials: W
authors.lastname: Chen
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Xu
authors.forename: Lu
authors.initials: L
authors.lastname: Li
authors.forename: Hongbin
authors.initials: H
authors.lastname: Zhai
authors.forename: Zhong
authors.initials: Z
authors.lastname: Li
mesh_terms: D000818:Animals; D001042:Aphids; D004095:Dihydropyridines / Q000737:chemistry*; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009538:Nicotine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004095:Dihydropyridines; D007306:Insecticides; D009538:Nicotine; C038806:1,4-dihydropyridine