Molecular suicide notes: last call from apoptosing cells.
Dying cells actively attract professional phagocytes by sending out soluble 'find-me' signals. The characterization and identification of the corresponding molecular entities have revealed that 'find-me' signals come in different flavors, including peptides, proteins, lipids and complex structures, such as apoptotic microblebs. With the very recent report by Elliott et al., nucleotides as a novel nuance enter the menu.
Peter
Christoph
C
Section of Molecular Gastroenterology, Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany.
Wesselborg
Sebastian
S
Lauber
Kirsten
K
D000818:Animals; D017209:Apoptosis; D002465:Cell Movement; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009711:Nucleotides / Q000378:metabolism; D010587:Phagocytosis; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction
D009711:Nucleotides; D011956:Receptors, Cell Surface