title: Wireless capsule endoscopy in enteropathy induced by nonsteroidal anti-inflammatory drugs in pigs.
abstract: OBJECTIVE
  The aim of this study is to evaluate the diagnostic yield of capsule endoscopy in nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy in pigs.
  
  
  METHODS
  Indomethacin (400 mg/day) was administrated orally for 10 days to eight female pigs weighing 36.3+/-2.4 kg. Afterwards, capsule endoscopy was performed, using the EndoCapsule system (Olympus Optical Co., Tokyo, Japan). The following morning, pharmacological euthanasia and immediate autopsy were performed.
  
  
  RESULTS
  Small bowel injury compatible with NSAID-induced enteropathy was observed in 7/8 animals. The most common lesions were red spots and erosions. Ulcers and small intestinal bleeding were identified sporadically. Sensitivity and specificity of capsule endoscopy were 83.3% and 95.8%, respectively.
  
  
  CONCLUSIONS
  Our results indicate that wireless capsule endoscopy is a highly accurate noninvasive method for evaluation of experimental NSAID-induced enteropathy.
authors.affiliation: Second Department of Internal Medicine, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Teaching Hospital, Hradec Králové, Czech Republic. tacheci@gmail.com
authors.forename: Ilja
authors.initials: I
authors.lastname: Tachecí
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Kvetina
authors.forename: Jan
authors.initials: J
authors.lastname: Bures
authors.forename: Jan
authors.initials: J
authors.lastname: Osterreicher
authors.forename: Martin
authors.initials: M
authors.lastname: Kunes
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Pejchal
authors.forename: Stanislav
authors.initials: S
authors.lastname: Rejchrt
authors.forename: Stanislav
authors.initials: S
authors.lastname: Spelda
authors.forename: Marcela
authors.initials: M
authors.lastname: Kopácová
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D053704:Capsule Endoscopy; D004195:Disease Models, Animal; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000175:diagnosis; D004386:Duodenum / Q000473:pathology; D005260:Female; D007082:Ileum / Q000473:pathology; D007213:Indomethacin; D007410:Intestinal Diseases / Q000139:chemically induced / Q000175:diagnosis*; D007413:Intestinal Mucosa / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology*; D007583:Jejunum / Q000473:pathology; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced / Q000175:diagnosis; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D034421:Sus scrofa
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin