title: Biomarkers for prostate cancer detection.
abstract: Since its approval by the US FDA in 1986, prostate-specific antigen (PSA) has been employed to monitor men with a diagnosis of prostate cancer. In 1994, PSA was approved for use in prostate cancer screening and has been employed worldwide. However, due to the limited specificity of PSA for the disease, novel biomarkers are needed for detecting prostate cancer and for determining which cancers need to be treated. This review will discuss the development of new biomarkers for prostate cancer detection and disease prognostication, focusing on recent progress and particular topical issues related to the development and validation of these new markers.
authors.affiliation: Department of Urology, University of Texas Health Sciences Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284-7840, USA. reeda2@uthscsa.edu
authors.forename: Amanda Beth
authors.initials: AB
authors.lastname: Reed
authors.forename: Dipen J
authors.initials: DJ
authors.lastname: Parekh
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D012680:Sensitivity and Specificity; D054928:Validation Studies as Topic
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen