Pattern of oseltamivir ingestions reported to Texas poison centers.
During serious influenza outbreaks, the number of oseltamivir exposures reported to poison centers might be expected to increase. This investigation describes the pattern of oseltamivir ingestions reported to Texas poison centers during 2000-2008. Of 298 total ingestions, 91.9% occurred in December-March, 76.8% involved patients aged 0-19 years, 72.5% resulted from therapeutic error, 90.0% were managed on-site, and 80.0% had no effect. The most frequently reported adverse clinical effects were vomiting (7.5%), nausea (3.8%), and abdominal pain (3.8%). Oseltamivir ingestions were reported to Texas poison centers primarily during periods of influenza outbreak. Most involved children, resulted from therapeutic error, and were managed on-site without serious outcome.
Forrester
Mathias B
MB
Texas Department of State Health Services, Austin, Texas 78756, USA. mathias.forrester@dshs.state.tx.us
D000059:Accidents / Q000706:statistics & numerical data; D000375:Aging; D000998:Antiviral Agents / Q000506:poisoning*; D004196:Disease Outbreaks; D004791:Enzyme Inhibitors / Q000506:poisoning*; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000453:epidemiology; D008297:Male; D008508:Medication Errors / Q000706:statistics & numerical data*; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D053139:Oseltamivir / Q000009:adverse effects / Q000506:poisoning*; D011039:Poison Control Centers / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012621:Seasons; D013406:Suicide, Attempted / Q000706:statistics & numerical data; D013781:Texas / Q000453:epidemiology
D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D053139:Oseltamivir; D009439:Neuraminidase