title: [A case of Langerhans cell histiocytosis coincident with severe external ear canal inflammation].
abstract: We report a case of Langerhans cell histiocytosis (LCH), a rare disease caused by the proliferation of abnormal Langerhans cells, coincident with severe external ear canal inflammation. A 27-year-old man with a 1-year history of external ear canal discharge was found in computed tomography (CT) to have left temporal bone erosion with tissue granulation. Chest X-ray showed pulmonary fibrosis, necessitating transbronchial lung biopsy that yielded a definitive diagnosis of multisystem, multisite LCH involving the bone, skin, lung, pituitary, thyroid, and lymph node systems. He underwent combination chemotherapy directed by the Japan LCH Study Group. LCH should therefore be considered in the case of a patient with severe external ear canal inflammation coincident with temporal bone erosion.
authors.affiliation: Department of Otorhinolaryngology, Yokohama Sakae Kyosai Hospital, Yokohama.
authors.forename: Maki
authors.initials: M
authors.lastname: Inoue
authors.forename: Chihiro
authors.initials: C
authors.lastname: Nakagawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Ogura
authors.forename: Ei
authors.initials: E
authors.lastname: Kamio
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tsukuda
mesh_terms: D000328:Adult; D004424:Ear Canal; D004427:Ear Diseases / Q000209:etiology; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007249:Inflammation; D008297:Male