title: Design and synthesis of novel bis-oximinoalkanoic acids as potent PPAR alpha agonists.
abstract: Bis-oximinoalkanoic acid derivatives were designed and synthesized to aid in the characterization of selective PPARalpha agonists by replacing the oxazole ring with flexible oximino group in the lipophilic tail part of a previously reported compound 3. Selected compounds 9d and 9m showed excellent potency and high selectivity towards PPARalpha in vitro. These compounds found effective in reducing serum triglycerides (TG) in vivo.
authors.affiliation: Zydus Research Centre, Sarkhej-Bavla NH 8A Moraiya, Ahmedabad 382 210, India. pingalihk@rediffmail.com
authors.forename: Harikishore
authors.initials: H
authors.lastname: Pingali
authors.forename: Mukul
authors.initials: M
authors.lastname: Jain
authors.forename: Shailesh
authors.initials: S
authors.lastname: Shah
authors.forename: Pandurang
authors.initials: P
authors.lastname: Zaware
authors.forename: Pankaj
authors.initials: P
authors.lastname: Makadia
authors.forename: Suresh
authors.initials: S
authors.lastname: Pola
authors.forename: Baban
authors.initials: B
authors.lastname: Thube
authors.forename: Darshit
authors.initials: D
authors.lastname: Patel
authors.forename: Pravin
authors.initials: P
authors.lastname: Patil
authors.forename: Priyanka
authors.initials: P
authors.lastname: Priyadarshini
authors.forename: Dinesh
authors.initials: D
authors.lastname: Suthar
authors.forename: Maanan
authors.initials: M
authors.lastname: Shah
authors.forename: Suresh
authors.initials: S
authors.lastname: Giri
authors.forename: Pankaj
authors.initials: P
authors.lastname: Patel
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis; D000473:Alkanes / Q000138:chemical synthesis*; D000818:Animals; D015195:Drug Design; D006801:Humans; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000378:metabolism; D051379:Mice; D010080:Oxazoles / Q000138:chemical synthesis*; D047493:PPAR alpha / Q000819:agonists* / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
chemical_list: D000098:Acetophenones; D000473:Alkanes; D000960:Hypolipidemic Agents; D010080:Oxazoles; D047493:PPAR alpha; D014280:Triglycerides; C038699:acetophenone