Maternal diet during pregnancy and allergic sensitization in the offspring by 5 yrs of age: a prospective cohort study.
To examine the effect of maternal diet during pregnancy on allergic sensitization in the offspring by 5 yrs of age. The Finnish type 1 Diabetes Prediction and Prevention Nutrition Study. A population-based cohort study with 5-yr follow-up. A total of 931 children with human leukocyte antigen-conferred susceptibility to type 1 diabetes for whom maternal pregnancy food frequency questionnaire data and allergen-specific immunoglobulin E measurement at 5 yrs were available. Increasing maternal consumption of citrus fruits [odds ratio (OR) = 1.14, 95% confidence interval (CI) = 1.05-1.25] and total fruit (OR = 1.36, 95% CI = 1.09-1.70) were positively associated with sensitization to inhalant allergens, after adjustment for potential confounders. Maternal intake of vitamin D (OR = 0.56, 95% CI = 0.35-0.91) was inversely associated with sensitization to food allergens. Maternal consumption of citrus fruits during pregnancy may increase the risk to allergic sensitization in the offspring, whereas vitamin D intake may have a beneficial effect. Further studies are required to define more closely the putative effect of maternal intake of polyunsaturated fatty acids on development of allergic diseases in the offspring.
Nwaru
Bright I
BI
Tampere School of Public Health, University of Tampere, Tampere, Finland. bright.nwaru@uta.fi
Ahonen
Suvi
S
Kaila
Minna
M
Erkkola
Maijaliisa
M
Haapala
Anna-Maija
AM
Kronberg-Kippilä
Carina
C
Veijola
Riitta
R
Ilonen
Jorma
J
Simell
Olli
O
Knip
Mikael
M
Virtanen
Suvi M
SM
D000485:Allergens / Q000276:immunology*; D000818:Animals; D002675:Child, Preschool; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D004032:Diet; D005260:Female; D005387:Finland / Q000453:epidemiology; D005512:Food Hypersensitivity / Q000453:epidemiology / Q000209:etiology; D005638:Fruit / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000209:etiology; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D039401:Prenatal Nutritional Physiological Phenomena; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000008:administration & dosage / Q000276:immunology
D000485:Allergens; D014807:Vitamin D; D007073:Immunoglobulin E