title: Two cases of bovine male pseudohermaphrodites with different endocrinological and pathological findings.
abstract: Two cases of bovine male pseudohermaphrodites (PH) were subjected for clinical investigation with transrectal ultrasonography, endocrinology with adoption of hCG-stimulation test, cytogenetics with analysis of sex chromosome and Y-specific DNA, and finally histological examination. Results were compared with normal calves. Case 1 was a 10-month-old calf with XX/XY chimeras, showing elevation of testosterone (T) levels, but no change in progesterone (P(4)) after hCG test, and possessed atrophied testes in the cavitas pelvis. Case 2 was an 18-month-old calf with SRY positive-XY chromosome, showing lower level of plasma T and P(4) after hCG test, and possessed atrophied testes and undifferentiated genital ducts. Both cases possessed female-like external genitalia with similar pathological findings, however endocrinological and cytogenetical aspects were different each other.
authors.affiliation: Department of Clinical Veterinary Science, United Graduate School of Veterinary Science, Yamaguchi University.
authors.forename: Chiho
authors.initials: C
authors.lastname: Moriyama
authors.forename: Mineto
authors.initials: M
authors.lastname: Tani
authors.forename: Kazumi
authors.initials: K
authors.lastname: Nibe
authors.forename: Go
authors.initials: G
authors.lastname: Kitahara
authors.forename: Shingo
authors.initials: S
authors.lastname: Haneda
authors.forename: Motozumi
authors.initials: M
authors.lastname: Matsui
authors.forename: Yoh-Iichi
authors.initials: YI
authors.lastname: Miyake
authors.forename: Shunichi
authors.initials: S
authors.lastname: Kamimura
mesh_terms: D000818:Animals; D002417:Cattle / Q000033:anatomy & histology*; D002418:Cattle Diseases / Q000235:genetics* / Q000473:pathology*; D004247:DNA / Q000235:genetics; D017931:DNA Primers; D012734:Disorders of Sex Development / Q000235:genetics* / Q000473:pathology / Q000662:veterinary*; D005260:Female; D024282:Genes, sry; D005836:Genitalia, Female / Q000033:anatomy & histology; D007985:Leydig Cells / Q000473:pathology; D008297:Male; D016133:Polymerase Chain Reaction; D012671:Seminiferous Tubules / Q000033:anatomy & histology / Q000473:pathology; D013091:Spermatogenesis; D014998:Y Chromosome
chemical_list: D017931:DNA Primers; D004247:DNA