title: N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.
abstract: A novel class of compounds containing N-sulfonylanthranilic acid was found to specifically inhibit dengue viral polymerase. The structural requirements for inhibition and a preliminary structure-activity relationship are described. A UV cross-linking experiment was used to map the allosteric binding site of the compound on the viral polymerase.
authors.affiliation: Novartis Institute for Tropical Diseases, Chromos, 138670, Singapore.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yin
authors.forename: Yen-Liang
authors.initials: YL
authors.lastname: Chen
authors.forename: Ravinder Reddy
authors.initials: RR
authors.lastname: Kondreddi
authors.forename: Wai Ling
authors.initials: WL
authors.lastname: Chan
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Ru Hui
authors.initials: RH
authors.lastname: Ng
authors.forename: Joanne Y H
authors.initials: JY
authors.lastname: Lim
authors.forename: Wan Yen
authors.initials: WY
authors.lastname: Lee
authors.forename: Duraiswamy A
authors.initials: DA
authors.lastname: Jeyaraj
authors.forename: Pornwaratt
authors.initials: P
authors.lastname: Niyomrattanakit
authors.forename: Daying
authors.initials: D
authors.lastname: Wen
authors.forename: Alex
authors.initials: A
authors.lastname: Chao
authors.forename: J Fraser
authors.initials: JF
authors.lastname: Glickman
authors.forename: Hans
authors.initials: H
authors.lastname: Voshol
authors.forename: Dieter
authors.initials: D
authors.lastname: Mueller
authors.forename: Carsten
authors.initials: C
authors.lastname: Spanka
authors.forename: Sigmar
authors.initials: S
authors.lastname: Dressler
authors.forename: Shahul
authors.initials: S
authors.lastname: Nilar
authors.forename: Subhash G
authors.initials: SG
authors.lastname: Vasudevan
authors.forename: Pei-Yong
authors.initials: PY
authors.lastname: Shi
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Keller
mesh_terms: D001665:Binding Sites; D003716:Dengue Virus / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D013329:Structure-Activity Relationship; D013441:Sulfinic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D062367:ortho-Aminobenzoates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D013441:Sulfinic Acids; D062367:ortho-Aminobenzoates; D012324:RNA-Dependent RNA Polymerase