title: Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
abstract: Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV(1)) and its ratio to forced vital capacity (FEV(1)/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV(1)/FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV(1) (INTS12-GSTCD-NPNT) at or near genome-wide significance (P < 5 x 10(-8)) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.
authors.affiliation: Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
authors.forename: Dana B
authors.initials: DB
authors.lastname: Hancock
authors.forename: Mark
authors.initials: M
authors.lastname: Eijgelsheim
authors.forename: Jemma B
authors.initials: JB
authors.lastname: Wilk
authors.forename: Sina A
authors.initials: SA
authors.lastname: Gharib
authors.forename: Laura R
authors.initials: LR
authors.lastname: Loehr
authors.forename: Kristin D
authors.initials: KD
authors.lastname: Marciante
authors.forename: Nora
authors.initials: N
authors.lastname: Franceschini
authors.forename: Yannick M T A
authors.initials: YM
authors.lastname: van Durme
authors.forename: Ting-Hsu
authors.initials: TH
authors.lastname: Chen
authors.forename: R Graham
authors.initials: RG
authors.lastname: Barr
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Schabath
authors.forename: David J
authors.initials: DJ
authors.lastname: Couper
authors.forename: Guy G
authors.initials: GG
authors.lastname: Brusselle
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Psaty
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: van Duijn
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.forename: André G
authors.initials: AG
authors.lastname: Uitterlinden
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.forename: Naresh M
authors.initials: NM
authors.lastname: Punjabi
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivadeneira
authors.forename: Alanna C
authors.initials: AC
authors.lastname: Morrison
authors.forename: Paul L
authors.initials: PL
authors.lastname: Enright
authors.forename: Kari E
authors.initials: KE
authors.lastname: North
authors.forename: Susan R
authors.initials: SR
authors.lastname: Heckbert
authors.forename: Thomas
authors.initials: T
authors.lastname: Lumley
authors.forename: Bruno H C
authors.initials: BH
authors.lastname: Stricker
authors.forename: George T
authors.initials: GT
authors.lastname: O'Connor
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: London
mesh_terms: D030541:Databases, Genetic; D005260:Female; D005541:Forced Expiratory Volume; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015894:Genome, Human / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000502:physiology* / Q000503:physiopathology; D008171:Lung Diseases / Q000235:genetics / Q000503:physiopathology; D008297:Male; D015201:Meta-Analysis as Topic; D020641:Polymorphism, Single Nucleotide; D013147:Spirometry; D014797:Vital Capacity