Pd(II)-catalyzed C-H activation/aryl-aryl coupling of phenol esters.
Although nitrogen-containing group-directed cyclopalladation reactions have been well-known, Pd(II) insertion into C-H bonds promoted by coordination of an oxygen-only group to the palladium remains rather rare. In the present study, the first cyclopalladation complex formed from a simple phenol ester was characterized by X-ray crystallography. A promising protocol for the ortho C-H activation/aryl-aryl coupling of phenol esters that was not sensitive to moisture or air was then established. The utility of the reaction was demonstrated for the synthesis of useful phenol derivatives.
Xiao
Bin
B
Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
Fu
Yao
Y
Xu
Jun
J
Gong
Tian-Jun
TJ
Dai
Jian-Jun
JJ
Yi
Jun
J
Liu
Lei
L