Terahertz absorption spectra of original and generic ceftazidime.
The absorption spectra of ceftazidime and its generic versions (Modacin, Mosyl, and Mobenzocin) have been measured by terahertz time domain spectroscopy (THz-TDS). Differences in the THz absorption were observed between the original and generic versions. The results show small, but significant differences in the states of ceftazidime hydrate between the original and generic versions. THz-TDS can be used to evaluate the stability of medicines as well as to control their quality.
Kawase
Masaya
M
Nagahama Institute of Bio-science and Technology, 1266 Tamura, Nagahama, Shiga 526-0829, Japan. m_kawase@nagahama-i-bio.ac.jp
Saito
Tadashi
T
Ogawa
Masafumi
M
Uejima
Hideki
H
Hatsuda
Yasutoshi
Y
Kawanishi
Sonoyo
S
Hirotani
Yoshihiko
Y
Myotoku
Michiaki
M
Ikeda
Kenji
K
Takano
Keisuke
K
Hangyo
Masanori
M
Yamamoto
Kohji
K
Tani
Masahiko
M
D000042:Absorption; D002442:Ceftazidime / Q000737:chemistry*; D004355:Drug Stability; D016568:Drugs, Generic / Q000737:chemistry*; D006358:Hot Temperature; D013057:Spectrum Analysis
D016568:Drugs, Generic; D002442:Ceftazidime