Global signatures of protein and mRNA expression levels.
Cellular states are determined by differential expression of the cell's proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contributors to gene expression regulation. This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters. We summarize the information that can be derived from comparison of protein and mRNA expression levels and discuss how corresponding sequence characteristics suggest modes of regulation.
de Sousa Abreu
Raquel
R
Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, TX, USA.
Penalva
Luiz O
LO
Marcotte
Edward M
EM
Vogel
Christine
C
D019295:Computational Biology / Q000379:methods*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D006801:Humans; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000235:genetics; D054875:Ubiquitination; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
D011506:Proteins; D012333:RNA, Messenger