Host genetic studies in human ocular Chlamydial infection.
Several human and animal models and methods have been used to dissect genetic contributions to immunity and pathogenesis of chlamydial diseases. Considerable achievements have been made in this field of host genetics. The hope is that these studies will lead to medical applications by helping to elicit the function of genes that are involved in host defense against chlamydia and in progression to severe sequelae. In the present article, we review a selection of findings in the forward genetics of ocular Chlamydia trachomatis infection in humans.
Natividad-Sancho
A
A
London School of Hygiene and Tropical Medicine, London University, London WC1E 7HT, UK.
Holland
M J
MJ
Mabey
D C W
DC
Bailey
R L
RL
D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics; D016753:Interleukin-10 / Q000235:genetics; D020780:Matrix Metalloproteinase 9 / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D018418:Th2 Cells / Q000276:immunology; D014141:Trachoma / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D006680:HLA Antigens; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma; D020780:Matrix Metalloproteinase 9