[Membrane and functional effects of vinpocetine and tocopherol in rats with experimental cerebral ischemia].
The membrane, antioxidant and functional effects of vinpocetine and a-tocopherol have been investigated under conditions of acute experimental cerebral ischemia in rats. Vinpocetine administration decreased accumulation of lysophospholipids in brain plasma membranes. Vinpocetine also blocked accumulation of conjugated dienes (CD). alpha-Tocopherol inhibited augmentation in CD content and did not reduce the level of lysophospholipids in brain plasma membranes. Functional consequences of membrane impairments were also detected in some behavioral tests and physical capabilities. Administration of both vinpocetine and alpha-tocopherol decreased manifestations of the altered parameters induced by cerebral ischemia and vinpocetine was more effective than alpha-tocopherol.
Vishnevskiĭ
A A
AA
Korotkevich
I G
IG
Zhaparalieva
Ch O
ChO
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D002545:Brain Ischemia / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D024505:Tocopherols / Q000494:pharmacology*; D014748:Vinca Alkaloids / Q000494:pharmacology*
D000927:Anticonvulsants; D000975:Antioxidants; D008246:Lysophospholipids; D014748:Vinca Alkaloids; C013983:vinpocetine; D024505:Tocopherols