title: Development and validation of a quantitative method for the selective determination of tin species in tin octoate by differential pulse polarography.
abstract: Tin octoate is used as a catalyst in the synthesis of polydimethylsiloxane (PDMS), a room temperature vulcanizing (RTV) silicone rubber. This rubber is largely used in the medical field due to its great biocompatibility. In this framework, a high-speed and costless analytical method for the determination of stannic ions, Sn(IV), in the presence of stannous ions, Sn(II), has been developed. The separation of these two ions was carried out using differential pulse polarography (DPP). For this purpose, the tin species contents in the catalyst is quantitatively extracted under inert condition to avoid any changes in the ratio Sn(IV)/Sn(II). Polarography showed well-shaped oxidation and reduction peaks respectively at -650 and -860mV for stannous ions. The peak of the stannic ion was well separated and appeared at -1210mV. Many parameters such as extraction process, extraction time, pH, chelating agents and polarographic conditions were optimized. We have also demonstrated that no oxidation of the stannous ions occurred during the sample preparation. The dosing range considered in this study extends between 10 and 40mug/mL, corresponding to 6.8% and 27.2% of the degradation product (Sn(IV)) in the catalyst, regarding to the sampling. Finally this method was successfully validated using the total error concept.
authors.affiliation: Laboratory of Analytical Chemistry, CIRM, Department of Pharmacy, University of Liège, Avenue de l'Hôpital 1, B36, 4000 Liège, Belgium. chubert@ulg.ac.be
authors.forename: C
authors.initials: C
authors.lastname: Hubert
authors.forename: E
authors.initials: E
authors.lastname: Ziémons
authors.forename: E
authors.initials: E
authors.lastname: Rozet
authors.forename: A
authors.initials: A
authors.lastname: Breuer
authors.forename: A
authors.initials: A
authors.lastname: Lambert
authors.forename: C
authors.initials: C
authors.lastname: Jasselette
authors.forename: C
authors.initials: C
authors.lastname: De Bleye
authors.forename: R
authors.initials: R
authors.lastname: Lejeune
authors.forename: Ph
authors.initials: P
authors.lastname: Hubert