title: Stimulation of anti-polio and anti-HSV IgA pre-plasma cell response in blood following parenteral immunization with tetanus-diphtheria vaccine.
abstract: Systemic immunization can elicit a significant response of IgG producing activated B cell subsets in human blood, part of which is not toward the vaccine. However, the effect of vaccination on IgA antibody secreting B cell subsets has had limited investigation. We immunized healthy, adult volunteers with a tetanus/diphtheria vaccine and observed a significant burst of IgA-secreting pre-plasma cells (PPC). Isolated PPC produced IgG, but not IgA antibody to tetanus antigen, and produced IgA and IgG antibody specific for poliovirus and herpes simplex virus. Thus, a vaccine that generates a systemic recall response to tetanus also induces blood PPC secreting IgA and IgG antibody relevant to mucosal protection.
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University, Histocompatibility Lab, Hamilton Health Sciences, Hamilton, ON, Canada.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Fernandes
authors.forename: Susan
authors.initials: S
authors.lastname: Wasserman
authors.forename: Denis P
authors.initials: DP
authors.lastname: Snider
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D001769:Blood / Q000276:immunology*; D022422:Diphtheria-Tetanus Vaccine / Q000008:administration & dosage*; D022301:Herpes Simplex Virus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007273:Injections, Intramuscular; D008875:Middle Aged; D010950:Plasma Cells / Q000276:immunology*; D023321:Poliovirus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D022422:Diphtheria-Tetanus Vaccine; D022301:Herpes Simplex Virus Vaccines; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D023321:Poliovirus Vaccines