Role of meconium in the reaction of airways smooth musculature in the newborn with meconium aspiration syndrome (MAS).
The role of meconium in the respiratory system was studied in newborns, who died from various causes (250 up to 3000 g of weight). We monitored tracheal rings response to dopamine, serotonin and ethanol in different concentrations (dopamine: 0,05 mg/ml, 0,5 mg/ml, 5 mg/ml; serotonin (5-HT): 10-4, 10-3, 10-2, 10-1 mol/dm3; ethanol: 0,02 ml, 0,5 ml, 1,0 ml; 96%). Tracheal smooth musculature tonus (TSM) was examined in 48 tracheal preparations taken after the newborn exitus due to different reasons. Based on functional researche of isolated preparations of tracheas, it may be concluded that: aspiration of meconium has not changed the response of TSM to dopamine, serotonin and ethanol (p>0,1) in comparison with the control group, which have died due to different lung inflammatory processes (e.g. pneumonia, bronchopneumonia, atelectasis, cerebral hemorrhage). The results suggest that meconium does not potentiate the constricting action of dopamine, serotonin and ethanol in tracheobronchial system. Meconium causes mild relaxation of the TSM through a mechanism that is not intermediated by the products of cyclooxygenases (prostaglandins, prostacyclins) from the tracheal epithelium or proteins. Also, as it seems, the direct activity of many tested acids in the smooth musculature has no significant impact on increase of the airways tonus in MAS syndrome.
Islami
Hilmi
H
Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinics Center N.N. 10000, Prishtina, Kosovo.
Bexheti
Sadi
S
Shabani
Ragip
R
Nuraj
Bajram
B
Zeqiri
Fehmi
F
Sukalo
Aziz
A
Kurtishi
Ilir
I
Kutllovci
Skender
S
Qorraj
Hasime
H
Disha
Mentor
M
D004298:Dopamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D007231:Infant, Newborn; D008470:Meconium / Q000502:physiology*; D008471:Meconium Aspiration Syndrome / Q000503:physiopathology*; D009130:Muscle, Smooth / Q000187:drug effects / Q000503:physiopathology*; D012701:Serotonin / Q000494:pharmacology; D014132:Trachea / Q000503:physiopathology*
D012701:Serotonin; D000431:Ethanol; D004298:Dopamine