title: Erythrocyte fatty acid composition and insulin sensitivity in daughters of Type 2 diabetic patients and women with no family history of diabetes.
abstract: BACKGROUND
  There is evidence that the impact of environmental factors on insulin sensitivity is modified by the presence of family history of diabetes.
  
  
  OBJECTIVE
  To compare the association between the erythrocyte phospholipid fatty acid composition (a biomarker of dietary fatty acids) and insulin sensitivity in daughters of Type 2 diabetic patients with the corresponding association in women without family history of diabetes.
  
  
  METHODS
  Eighteen offspring of Type 2 diabetic patients [age 30+/-6.5 yr; body mass index (BMI) 22.2+/-2.5 kg/m2; body fat 31.8+/-5.1%] and 18 matched women (age 30.1+/-6.8 yr; BMI 22.2+/-1.8 kg/m2; body fat 32.2+/-6.0%) participated in the study.
  
  
  RESULTS
  Insulin Sensitivity Index (ISI)-Matsuda tended to be lower (p=0.06) in the Offspring than the control group. Weight proportions of erythrocyte phospholipid saturated (SFA), polyunsaturated (PUFA), and monounsaturated fatty acids (MUFA) were similar between the two groups. In the offspring, erythrocyte total SFA were negatively correlated with ISI-Matsuda [r=-0.47, p<0.05), ISI(gly)-Belfiore (r=-0.52, p<0.05) and ISI(ffa)-Belfiore (r=-0.53, p<0.05)], whereas total PUFA were positively correlated with insulin sensitivity [ISI-Matsuda, r=0.46, p<0.05; ISI(gly)-Belfiore, r=0.53, p<0.05; ISI(ffa)-Belfiore, r=0.54, p<0.05]. No significant correlations were observed in the control group.
  
  
  CONCLUSIONS
  The associations between erythrocyte fatty acid composition and insulin sensitivity are distinct between daughters of Type 2 diabetic patients and women without family history of diabetes.
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
authors.forename: G
authors.initials: G
authors.lastname: Ntali
authors.forename: C
authors.initials: C
authors.lastname: Koutsari
authors.forename: K
authors.initials: K
authors.lastname: Karakike
authors.forename: P
authors.initials: P
authors.lastname: Makras
authors.forename: F
authors.initials: F
authors.lastname: Skopouli
authors.forename: M
authors.initials: M
authors.lastname: Mc Milan
authors.forename: C
authors.initials: C
authors.lastname: Slater
authors.forename: S
authors.initials: S
authors.lastname: Higgins
authors.forename: A
authors.initials: A
authors.lastname: Zampelas
authors.forename: D
authors.initials: D
authors.lastname: Malkova
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D001823:Body Composition / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000235:genetics*; D004912:Erythrocytes / Q000737:chemistry*; D005190:Family; D005227:Fatty Acids / Q000097:blood*; D005229:Fatty Acids, Monounsaturated / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D008875:Middle Aged; D009043:Motor Activity; D010743:Phospholipids / Q000097:blood; D055815:Young Adult
chemical_list: D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D010743:Phospholipids