Antitumor and antioxidant role of Chrysaora quinquecirrha (sea nettle) nematocyst venom peptide against Ehrlich ascites carcinoma in Swiss Albino mice.
This investigation aims to evaluate the antitumor and antioxidant potential of Chrysaora quinquecirrha (sea nettle) nematocyst venom on Ehrlich ascites carcinoma (EAC) tumor model. Tumor was induced in mice by intraperitoneal injection of EAC cells. The antitumor effect of sea nettle nematocyst venom (SNV) peptide was evaluated by assessing in vitro cytotoxicity, survival time, hematological, and antioxidant parameters. Intraperitoneal injection of SNV peptide increased the survival time of the EAC-bearing mice. The SNV peptide brought back the altered levels of the hematological and antioxidant parameters in a dose dependent manner in EAC-bearing mice. The results were comparable to that of the result obtained from the animals treated with the standard drug 5-fluorouracil (20 mg/kg bw). Thus, present study revealed that SNV peptide possessed significant antitumor and antioxidant activity.
Balamurugan
Elumalai
E
Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu, India. elubalu@gmail.com
Reddy
Bandugula Venkata
BV
Menon
Venugopal Padmanaban
VP
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D000975:Antioxidants / Q000737:chemistry / Q000627:therapeutic use*; D001835:Body Weight; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000378:metabolism; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D010455:Peptides / Q000737:chemistry / Q000627:therapeutic use*; D037441:Sea Nettle, East Coast / Q000737:chemistry*; D015996:Survival Rate; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014688:Venoms / Q000737:chemistry / Q000627:therapeutic use
D000970:Antineoplastic Agents; D000975:Antioxidants; D010455:Peptides; D017392:Thiobarbituric Acid Reactive Substances; D014688:Venoms; D005978:Glutathione