A beta-carboline alkaloid from the Papua New Guinea marine sponge hyrtios reticulatus.
A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid, named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure was elucidated from spectroscopic data, including (1)H-(15)N HMBC NMR experiments, which provided complementary (15)N chemical shift information in support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lines.
Inman
Wayne D
WD
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA.
Bray
Walter M
WM
Gassner
Nadine C
NC
Lokey
R Scott
RS
Tenney
Karen
K
Shen
Young Yongchun
YY
Tendyke
Karen
K
Suh
Ted
T
Crews
Phillip
P
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D019073:HT29 Cells; D006367:HeLa Cells; D006801:Humans; D008297:Male; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010219:Papua New Guinea; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism
D000470:Alkaloids; D002243:Carbolines; C548211:hyrtiocarboline