[Diffuse intrinsic brain stem glioma in children: current treatment and future directions].
Despite the numerous clinical trials undertaken, the prognosis of children with diffuse brain stem glioma remains very poor. This review examines the different strategies for the treatment of malignant brain stem glioma such as radiation therapy, concurrent radiochemotherapy, and classical cytotoxic drugs, with a particular focus on the novel targeted and antiangiogenic drugs recently introduced in pediatric oncology. The strategy using integrin inhibitors is discussed.
Leblond
P
P
Unité d'oncologie pédiatrique, centre Oscar-Lambret, 59020 Lille cedex, France. p-leblond@o-lambret.fr
Vinchon
M
M
Bernier-Chastagner
V
V
Chastagner
P
P
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D020295:Brain Stem Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy*; D002648:Child; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D005910:Glioma / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D011379:Prognosis; D018714:Radiotherapy, Adjuvant
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents