POEMS syndrome complicated by follicular lymphoma.
A 59-year-old woman presented with ascites and intraperitoneal lymph node swelling. Pathological examination of the lymph node revealed follicular lymphoma. After a lymph node biopsy, she developed atypical genital bleeding, multiple endocrine disorders, polyneuropathy with a high plasma level of vascular endothelial growth factor (VEGF), and was diagnosed with POEMS syndrome. Following administration of methyl prednisolone, ascites immediately decreased and her performance status improved; however, about 18 months later, renal failure occurred, and she died despite increased steroid dosage. Lymph node swelling is often found in POEMS syndrome; however, its histological appearance is not well known, and it is very rare to be concomitant with malignant lymphoma. Therefore, it is important to perform a lymph node biopsy and investigate it in relation with VEGF.
SASAKI
Takahide
T
Department of Internal Medicine, Kushiro Rosai Hospital.
OHNISHI
Shunsuke
S
ONISHI
Reizo
R
TAKEMURA
Ryou
R
KOBAYASHI
Yoshimitsu
Y
SUZUKI
Mio
M
DAZAI
Masayoshi
M
HATA
Tamotsu
T
YAMAMOTO
Junji
J
ODA
Hisashi
H
TAKAHASHI
Tatsuro
T
OGASAWARA
Kazuhiro
K
MIYAGISHIMA
Takuto
T
D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008224:Lymphoma, Follicular / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D008875:Middle Aged; D016878:POEMS Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
D015415:Biomarkers; D042461:Vascular Endothelial Growth Factor A; D011239:Prednisolone