title: Central venous saturation: a prognostic tool in cardiac surgery patients.
abstract: BACKGROUND
  Central venous oxygen saturation (ScvO(2)) is a valuable prognostic marker in sepsis. However, its value in cardiac surgery has not been assessed yet. This study aimed at evaluating ScvO(2) as a tool for predicting short-term organ dysfunction (OD) after cardiac surgery.
  
  
  METHODS
  A prospective cohort including cardiac surgery patients submitted to a goal-oriented therapy to maintain ScvO(2) above 70% was studied. Postoperative blood samples collected at 30 minutes (T1), 6 hours (T2), and 24 hours (T3) for ScvO(2) measurement were selected to further analysis. Two groups were formed according to the absence (G0) or presence (G1) of OD defined as a Sequential Organ Failure Assessment (SOFA) score >or=5 on the third postoperative day. A logistic regression analysis was performed to identify the variables independently associated with OD on the third postoperative day.
  
  
  RESULTS
  From the 246 patients included, 54 (22%) developed OD and were defined as G1. The mortality rates in G0 and G1 were 1.6% and 31.5%, respectively (P < .001). In the comparative analysis between G0 and G1, the ScvO(2) values were remarkably lower in G1 at T1 (66.2 +/- 9.2 vs 62.3 +/- 11.6; P = .009), T2 (69.6 +/- 5.9 vs 63.5 +/- 9.4; P <or= .001), and T3 (69.6 +/- 5.6 vs 64.6 +/- 6.4; P <or= .001). The variables independently associated with OD in the final logistic regression model were Cleveland score (95% CI: 1.13-1.44; OR: 1.27; P < .001), lactate at T3 (95% CI:1.21-3.15; OR 1.95; P = .006), BE at T3 (95% CI:0.69-0.93; OR 0.80; P = .005); ScvO(2) at T2 (95% CI:0.86-0.96; OR 0.91; P = .002), and ScvO(2) at T3 (95% CI:0.83-0.95; OR 0.89; P = .002).
  
  
  CONCLUSIONS
  Postoperative ScvO(2) can be a valuable tool to predict OD after major cardiac surgeries. Its kinetics should be carefully followed in that setting.
authors.affiliation: Hospital Pró-Cardíaco, Rio de Janeiro, Brazil, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. htannus@centroin.com.br
authors.forename: Pedro M
authors.initials: PM
authors.lastname: Nogueira
authors.forename: Hugo T
authors.initials: HT
authors.lastname: Mendonça-Filho
authors.forename: Luiz Antonio
authors.initials: LA
authors.lastname: Campos
authors.forename: Renato V
authors.initials: RV
authors.lastname: Gomes
authors.forename: Alexandre R
authors.initials: AR
authors.lastname: Felipe
authors.forename: Marco A
authors.initials: MA
authors.lastname: Fernandes
authors.forename: Cristiane A
authors.initials: CA
authors.lastname: Villela-Nogueira
authors.forename: José R
authors.initials: JR
authors.lastname: Rocco
mesh_terms: D000368:Aged; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002405:Catheterization, Central Venous; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000517:prevention & control; D010100:Oxygen / Q000097:blood*; D011182:Postoperative Care; D011183:Postoperative Complications / Q000517:prevention & control; D011379:Prognosis; D011446:Prospective Studies; D014680:Veins
chemical_list: D010100:Oxygen