title: Monobactam and aminoglycoside combination therapy against metallo-beta-lactamase-producing multidrug-resistant Pseudomonas aeruginosa screened using a 'break-point checkerboard plate'.
abstract: Metallo-beta-lactamase-producing multidrug-resistant Pseudomonas aeruginosa (MDR P. aeruginosa) is a cause of life-threatening infections. With parenteral colistin not available in Japan, we treated MDR P. aeruginosa sepsis with monobactam and aminoglycoside combination therapy, with screening using a 'break-point checkerboard plate'.
authors.affiliation: Department of Infectious Diseases, Toranomon Hospital, Tokyo, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Araoka
authors.forename: Masaru
authors.initials: M
authors.lastname: Baba
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Takagi
authors.forename: Naofumi
authors.initials: N
authors.lastname: Matsuno
authors.forename: Kazuya
authors.initials: K
authors.lastname: Ishiwata
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Nakano
authors.forename: Masanori
authors.initials: M
authors.lastname: Tsuji
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Sachiko
authors.initials: S
authors.lastname: Seo
authors.forename: Yuki
authors.initials: Y
authors.lastname: Asano-Mori
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Uchida
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Masuoka
authors.forename: Atsushi
authors.initials: A
authors.lastname: Wake
authors.forename: Shuichi
authors.initials: S
authors.lastname: Taniguchi
authors.forename: Akiko
authors.initials: A
authors.lastname: Yoneyama
mesh_terms: D000617:Aminoglycosides / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008826:Microbial Sensitivity Tests / Q000379:methods; D008875:Middle Aged; D008997:Monobactams / Q000627:therapeutic use*; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology; D016896:Treatment Outcome; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D008997:Monobactams; D001618:beta-Lactamases