title: Alfuzosin hydrochloride transdermal films: evaluation of physicochemical, in vitro human cadaver skin permeation and thermodynamic parameters.
abstract: OBJECTIVE
  The main objective of the investigation was to develop a transdermal therapeutic system for alfuzosin hydrochloride and to study the effects of polymeric system and loading dose on the in vitro skin permeation pattern.
  
  
  METHODS
  Principles of experimental design have been exploited to develop the dosage form. Ratio of ethyl cellulose (EC) and polyvinyl pyrrolidone (PVP) and loading dose were selected as independent variables and their influence on the cumulative amount of alfuzosin hydrochloride permeated per cm2 of human cadaver skin at 24 h (Q24), permeation flux (J) and steady state permeability coefficient (PSS) were studied using experimental design. Various physicochemical parameters of the transdermal films were also evaluated. Activation energy for in vitro transdermal permeation has been estimated.
  
  
  RESULTS
  Ratio of EC and PVP was found to be the main influential factor for all the dependent variables studied. Drug loading dose was also found to influence the dependent variables but to a lesser extent. Physicochemical parameters of the prepared films were evaluated and found satisfactory. Activation energy for alfuzosin permeation has also been estimated and reported.
  
  
  CONCLUSIONS
  The therapeutic system was found to be dermatologically non-irritant and hence, a therapeutically effective amount of alfuzosin hydrochloride can be delivered via a transdermal route.
authors.affiliation: College of Pharmaceutical Sciences, Mohuda, Berhampur, Orissa, India. saty3000@yahoo.com
authors.forename: Satyanarayan
authors.initials: S
authors.lastname: Pattnaik
authors.forename: Kalpana
authors.initials: K
authors.lastname: Swain
authors.forename: Parthagan
authors.initials: P
authors.lastname: Choudhury
authors.forename: Pradeepta K
authors.initials: PK
authors.lastname: Acharya
authors.forename: Subrata
authors.initials: S
authors.lastname: Mallick
mesh_terms: D000279:Administration, Cutaneous; D058668:Adrenergic alpha-1 Receptor Antagonists / Q000008:administration & dosage*; D000818:Animals; D002102:Cadaver; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D010539:Permeability; D011799:Quinazolines / Q000008:administration & dosage*; D011817:Rabbits; D012869:Skin Absorption; D013816:Thermodynamics
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D011799:Quinazolines; C047638:alfuzosin