A novel combination of mild electrical stimulation and hyperthermia: general concepts and applications.
This review discusses the basic concepts, effects and applications of hyperthermia and mild electrical stimulation (MES) using low-intensity direct current. It also proposes a novel combinatorial use of MES and hyperthermia, and briefly outlines the rationale and the effects of MES and hyperthermia combination treatment on certain diseases (diabetes, hepatic ischaemia/reperfusion injury and gastric ulcer). The integrated modalities of MES and hyperthermia might find therapeutic applications to stress-induced diseases and intractable diseases of dysregulated signalling pathways.
Kai
Hirofumi
H
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto, Japan. hirokai@gpo.kumamoto-u.ac.jp
Suico
Mary Ann
MA
Morino
Saori
S
Kondo
Tatsuya
T
Oba
Mariko
M
Noguchi
Mikiko
M
Shuto
Tsuyoshi
T
Araki
Eiichi
E
D000818:Animals; D004599:Electric Stimulation Therapy; D006979:Hyperthermia, Induced; D007328:Insulin / Q000502:physiology; D051379:Mice; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology; D015427:Reperfusion Injury / Q000628:therapy; D015398:Signal Transduction
D007328:Insulin; D051057:Proto-Oncogene Proteins c-akt