title: [(13)C]Methionine breath test as a marker for hepatic mitochondrial function in HIV-infected patients.
abstract: Metabolic disturbances such as dyslipidemia, lipodystrophy syndrome, visceral obesity, hyperlactatemia, diabetes mellitus, and hepatic steatosis have been recognized as serious complications in long-term antiretroviral-treated HIV-infected patients. The oxidative capacity of liver mitochondria plays a central role in their pathogenesis and can be analyzed using the [(13)C]methionine breath test. We analyzed hepatic mitochondrial function using the [(13)C]methionine breath test in antiretrovirally treated and untreated HIV-infected patients as well as HIV-negative controls. Patients with hepatic steatosis, hypertriglyceridemia, lipohypertrophy, and older age showed reduced methionine metabolism. Hepatic mitochondrial function is impaired in antiretroviral-treated HIV-infected patients with disturbances of lipid metabolism.
authors.affiliation: II. Medizinische Klinik und Poliklinik, Infektionsambulanz, Klinikum rechts der Isar, Technische Universität München, Munich, Germany. thomas.sternfeld@web.de
authors.forename: T
authors.initials: T
authors.lastname: Sternfeld
authors.forename: A
authors.initials: A
authors.lastname: Lorenz
authors.forename: M
authors.initials: M
authors.lastname: Schmid
authors.forename: A
authors.initials: A
authors.lastname: Schlamp
authors.forename: H
authors.initials: H
authors.lastname: Demmelmair
authors.forename: B
authors.initials: B
authors.lastname: Koletzko
authors.forename: J R
authors.initials: JR
authors.lastname: Bogner
mesh_terms: D000328:Adult; D000367:Age Factors; D001944:Breath Tests / Q000379:methods*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000378:metabolism / Q000821:virology; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D008107:Liver Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000821:virology; D008297:Male; D008715:Methionine / Q000378:metabolism*; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000378:metabolism* / Q000473:pathology; D015999:Multivariate Analysis; D015203:Reproducibility of Results
chemical_list: D008715:Methionine