title: One-pot tandem 1,4-1,2-addition of phosphites to quinolines.
abstract: Trialkyl and silylated dialkyl phosphites were evaluated as phosphorus nucleophiles for the addition to quinolines in a strong acidic medium allowing consecutive 1,4- and 1,2-addition breaking up the aromatic stabilisation, thereby leading to 2,4-diphosphono-1,2,3,4-tetrahydroquinolines in one single reaction step in moderate to good yields (2-84%).
authors.affiliation: Research Group SynBioC, Department of Organic Chemistry, Faculty of BioScience Engineering, Coupure Links 653, B-9000 Ghent, Belgium.
authors.forename: Ann
authors.initials: A
authors.lastname: De Blieck
authors.forename: Kurt G R
authors.initials: KG
authors.lastname: Masschelein
authors.forename: Fréderic
authors.initials: F
authors.lastname: Dhaene
authors.forename: Ewa
authors.initials: E
authors.lastname: Rozycka-Sokolowska
authors.forename: Bernard
authors.initials: B
authors.lastname: Marciniak
authors.forename: Jozef
authors.initials: J
authors.lastname: Drabowicz
authors.forename: Christian V
authors.initials: CV
authors.lastname: Stevens
mesh_terms: D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D010575:Pesticides / Q000138:chemical synthesis* / Q000737:chemistry; D017905:Phosphites / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010575:Pesticides; D017905:Phosphites; D011804:Quinolines