title: Prevention of hemoglobinopathies in Egypt.
abstract: The hemoglobin disorders are the most common clinically serious single gene disorders in the world. In Egypt, beta-thalassemia is the most common type with a carrier rate varying from 5.3 to > or =9% and a gene frequency of 0.03. So, it was estimated that 1,000/1.5 million per year live births will suffer from thalassemia disease in Egypt (total live births 1,936,205 in 2006). beta-Thalassemia creates a social and financial burden for the patients' family and the Egyptian government. The high frequency of beta-thalassemia carriers with increasing rate of newly born cases is a pressing reason for the importance to develop prevention program for beta-thalassemia in Egypt. Sickle-cell disease (SCD) is not frequent in Egypt except in the Oases where the carrier rate varies from 9 to 22%. Our objectives were to provide an in-depth analysis of the current status of hemoglobinopathies in Egypt and what we need for prevention of these diseases.
authors.affiliation: Pediatric Hematology Department, Cairo University, Cairo, Egypt. amalelbeshlawy@yahoo.com
authors.forename: Amal
authors.initials: A
authors.lastname: El-Beshlawy
authors.forename: Ilham
authors.initials: I
authors.lastname: Youssry
mesh_terms: D000755:Anemia, Sickle Cell / Q000453:epidemiology / Q000517:prevention & control; D004534:Egypt / Q000453:epidemiology; D006580:Genetic Carrier Screening; D005817:Genetic Counseling; D005820:Genetic Testing; D006453:Hemoglobinopathies / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D011291:Premarital Examinations; D011296:Prenatal Diagnosis; D013789:Thalassemia / Q000453:epidemiology / Q000517:prevention & control