A 6-mer photocontrolled oligonucleotide as an effective telomerase inhibitor.
Telomerase is a relevant target for cancer therapy. A small 6-mer psoralen-containing oligonucleotide is shown to cause efficient photo-cross-linking to human telomere DNA by G-quadruplex formation. The small, photocontrolled oligonucleotide shows effective telomerase inhibition, both in vitro and in vivo, only when light irradiated. Data suggest that it is a promising agent for the treatment of cancer.
Xu
Yan
Y
Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan. xuyan@mkomi.rcast.u-tokyo.ac.jp
Ito
Kenichiro
K
Suzuki
Yuta
Y
Komiyama
Makoto
M
D004247:DNA / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005363:Ficusin / Q000737:chemistry / Q000494:pharmacology*; D054856:G-Quadruplexes; D006801:Humans; D009841:Oligonucleotides / Q000737:chemistry / Q000494:pharmacology*; D010777:Photochemistry; D019098:Telomerase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D016615:Telomere / Q000737:chemistry
D004791:Enzyme Inhibitors; D009841:Oligonucleotides; D004247:DNA; D019098:Telomerase; D005363:Ficusin