Atypical presentation of angiosarcoma of the scalp in the setting of human immunodeficiency virus (HIV).
BACKGROUND
Angiosarcoma of the head and neck is an uncommon, aggressive malignant entity most commonly found in elderly Caucasian males. We present a case in a young black female with co-existing HIV. The atypical gender, age and race of the patient reflect the unusual clinical presentation of this case of angiosarcoma, attributable to the patient's HIV status.


METHODS
A 22 year old patient presented with a large unresectable lesion over the occiput with surrounding ulceration, satellite lesions and associated lymphadenopathy. She is HIV-infected with a CD4 count of 360 cells/microl. She was not on antiretroviral treatment based on South African treatment guidelines advocating antiretroviral treatment when the CD4 count is below 200 cells/microl, in the absence of other AIDS-defining illnesses.The patient was treated with a course of ifosfamide and anthracyline based chemotherapy. Disease progression was noted on chemotherapy and she was subsequently palliated with a course of radiotherapy. She had a satisfactory response with an improvement in local symptoms. She is currently receiving symptomatic care.


CONCLUSIONS
South Africa is at the epicenter of the HIV epidemic. Consequently, the management of patients in the field of oncology in our clinical practice is often burdened with malignancies manifesting with an atypical disease presentation and clinical course.
Govender
Poovandren S
PS
Department of Radiotherapy and Oncology, Nelson R, Mandela School of Medicine, University of Kwazulu Natal, Durban, South Africa. poovan.gov@gmail.com
D000328:Adult; D018943:Anthracyclines / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols; D018791:CD4 Lymphocyte Count; D003131:Combined Modality Therapy; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000628:therapy; D015497:HIV-1 / Q000472:pathogenicity*; D006258:Head and Neck Neoplasms / Q000209:etiology* / Q000628:therapy; D006394:Hemangiosarcoma / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D011879:Radiotherapy Dosage; D012535:Scalp / Q000473:pathology*; D055815:Young Adult
D018943:Anthracyclines; D007069:Ifosfamide