title: Nonhemolytic Streptococcus pyogenes isolates that lack large regions of the sag operon mediating streptolysin S production.
abstract: Among nonhemolytic Streptococcus pyogenes (group A streptococcus) strains (n = 9) isolated from patients with pharyngitis or acute otitis media, we identified three deletions in the region from the epf gene, encoding the extracellular matrix binding protein, to the sag operon, mediating streptolysin S production.
authors.affiliation: Laboratory of Molecular Epidemiology for Infectious Agents, Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Yoshino
authors.forename: Somay Y
authors.initials: SY
authors.lastname: Murayama
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Sunaoshi
authors.forename: Takeaki
authors.initials: T
authors.lastname: Wajima
authors.forename: Miki
authors.initials: M
authors.lastname: Takahashi
authors.forename: Junko
authors.initials: J
authors.lastname: Masaki
authors.forename: Iku
authors.initials: I
authors.lastname: Kurokawa
authors.forename: Kimiko
authors.initials: K
authors.lastname: Ubukata
mesh_terms: D000328:Adult; D001426:Bacterial Proteins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D005260:Female; D006460:Hemolysin Proteins / Q000096:biosynthesis; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009876:Operon; D010033:Otitis Media / Q000382:microbiology; D010612:Pharyngitis / Q000382:microbiology; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion; D013290:Streptococcal Infections / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000235:genetics* / Q000302:isolation & purification*; D013301:Streptolysins / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D006460:Hemolysin Proteins; D013301:Streptolysins; C026050:streptolysin S