title: Prevalence of obstructive sleep apnea in children and adolescents with sickle cell anemia.
abstract: OBJECTIVE
  To estimate the prevalence of obstructive sleep apnea syndrome (OSAS) in children and adolescents with sickle cell anemia (SCA); to investigate the possible correlation between mean annual hemoglobin level and total sleep time with SpO2 < 90%, as well as between mean annual hemoglobin level and total sleep time with SpO2 < 80%; and to investigate the possible correlation between apnea-hypopnea index (AHI) and painful crisis.
  
  
  METHODS
  The study involved 85 patients with SCA. The patients completed a questionnaire, were submitted to polysomnography and underwent clinical evaluation (by a pediatrician and an otolaryngologist). An AHI > 1 was considered indicative of a diagnosis of OSAS.
  
  
  RESULTS
  The prevalence of OSAS was 10.6%. We found a negative correlation between mean annual hemoglobin level and total sleep time with SpO2 < 90% (r = micro0.343; p = 0.002), as well as between mean annual hemoglobin level and total sleep time with SpO2 < 80% (r = micro0.270; p = 0.016). There was no association between AHI and painful crisis.
  
  
  CONCLUSIONS
  The prevalence of OSAS in this population was high (10.6%). Therefore, it is important to identify signs of OSAS as soon as possible and to determine the mean annual hemoglobin level because of the inverse correlation between that level and the total sleep time with SpO2 < 90% or < 80%.
authors.affiliation: Bahia Hospital Medical Center, Salvador, Brazil. cristinasalles@click21.com.br
authors.forename: Cristina
authors.initials: C
authors.lastname: Salles
authors.forename: Regina Terse Trindade
authors.initials: RT
authors.lastname: Ramos
authors.forename: Carla
authors.initials: C
authors.lastname: Daltro
authors.forename: Andréa
authors.initials: A
authors.lastname: Barral
authors.forename: Jamocyr Moura
authors.initials: JM
authors.lastname: Marinho
authors.forename: Marcos Almeida
authors.initials: MA
authors.lastname: Matos
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D015995:Prevalence; D012890:Sleep / Q000502:physiology; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000453:epidemiology*; D013997:Time Factors; D055815:Young Adult
chemical_list: D006454:Hemoglobins