Association of statins and diabetes mellitus.
For years, statins have been used to lower elevated total and low-density lipoprotein cholesterol levels while raising high-density lipoprotein cholesterol levels. Statins work by inhibiting HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase, thus stopping the conversion of HMG-CoA to mevalonate, which is found in the cholesterol synthesis cascade. Unfortunately, several studies have shown increased diagnosis and lack of glycemic control of diabetes mellitus when patients are taking high and/or long-term doses of statins, and several mechanisms have been identified that may help explain this side effect.
Hagedorn
Jonathan
J
Chicago Medical School, North Chicago, IL 60064, USA.
Arora
Rohit
R
D001786:Blood Glucose / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D003920:Diabetes Mellitus / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D013997:Time Factors
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002784:Cholesterol