title: Pd-catalyzed intramolecular oxyalkynylation of alkenes with hypervalent iodine.
abstract: The first example of intramolecular oxyalkynylation of nonactivated alkenes using oxidative Pd chemistry is reported. Both phenol and aromatic or aliphatic acid derivatives could be used under operator-friendly conditions (room temperature, technical solvents, under air). The discovery of the superiority of benziodoxolone-derived hypervalent iodine reagent 3d as an alkyne transfer reagent further expands the rapidly increasing utility of hypervalent iodine reagents in catalysis and is expected to have important implications for other similar processes.
authors.affiliation: Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fédérale de Lausanne, EPFL SB ISIC LCSO, BCH 4306, 1015 Lausanne, Switzerland.
authors.forename: Stefano
authors.initials: S
authors.lastname: Nicolai
authors.forename: Stéphane
authors.initials: S
authors.lastname: Erard
authors.forename: Davinia Fernández
authors.initials: DF
authors.lastname: González
authors.forename: Jérôme
authors.initials: J
authors.lastname: Waser
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000480:Alkynes; D009942:Organometallic Compounds; D010165:Palladium