Myc and a Cdk2 senescence switch.
Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition of Cdk2 may have therapeutic efficacy in the treatment of cancer.
van Riggelen
Jan
J
Felsher
Dean W
DW
D000818:Animals; D016922:Cellular Senescence / Q000502:physiology*; D051357:Cyclin-Dependent Kinase 2 / Q000502:physiology*; D016259:Genes, myc / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology
D051357:Cyclin-Dependent Kinase 2