Coordination to gallium(III) strongly enhances the potency of 2-pyridineformamide thiosemicarbazones against Cryptococcus opportunistic fungi.
A family of 2-pyridineformamide-derived thiosemicarbazones and their gallium(III) complexes were tested against several isolates of pathogenic Cryptococcus strains. On complexation the antifungal activity significantly increases, suggesting coordination to gallium(III) to be an interesting strategy of antifungal dose reduction.
Bastos
Thaíssa de Oliveira
Tde O
Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN), CP 941, 31161-970 Belo Horizonte, Brazil.
Soares
Betânia Maria
BM
Cisalpino
Patrícia Silva
PS
Mendes
Isolda Castro
IC
dos Santos
Raquel Gouvea
RG
Beraldo
Heloisa
H
D000935:Antifungal Agents / Q000494:pharmacology*; D003453:Cryptococcosis / Q000382:microbiology; D003454:Cryptococcus / Q000187:drug effects*; D004357:Drug Synergism; D005559:Formamides / Q000494:pharmacology*; D005708:Gallium / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000494:pharmacology*; D013882:Thiosemicarbazones / Q000494:pharmacology*
C532279:2-pyridineformamide; D000935:Antifungal Agents; D005559:Formamides; D011725:Pyridines; D013882:Thiosemicarbazones; D005708:Gallium