title: Practical one-pot two-step protocol for the microwave-assisted synthesis of highly functionalized rhodanine derivatives.
abstract: A fast and efficient protocol for the generation of substituted 5-arylidene rhodanines in a sequential one-pot two-step process combining the "Holmberg method" and the Knoevenagel condensation under microwave-assisted conditions has been developed. The final compounds 11a-k have been obtained in high yield and purity after a simple precipitation from methanol, making this procedure facile, practical, and rapid to execute.
authors.affiliation: Dipartimento Farmaco Chimico Tecnologico, University of Siena, Siena, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Radi
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Botta
authors.forename: Gianni
authors.initials: G
authors.lastname: Casaluce
authors.forename: Martina
authors.initials: M
authors.lastname: Bernardini
authors.forename: Maurizio
authors.initials: M
authors.lastname: Botta
mesh_terms: D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D015394:Molecular Structure; D012236:Rhodanine / Q000737:chemistry*; D013997:Time Factors
chemical_list: D012236:Rhodanine