Oxidation of lynestrenol by the fungus Cunninghamella elegans.
Transformation of lynestrenol (19-nor-17alpha-pregn-4-en-20-yn-17beta-ol) (1) was carried out by incubation with Cunninghamella elegans to obtain 19-nor-17alpha-pregn-4-en-20-yn-3-one-10beta,17beta-diol (2), 19-nor-17alpha-pregn-4-en-20-yn-3-one-6beta,17beta-diol (3), and 19-nor-17alpha-pregn-4-en-20-yn-3beta,6beta,17beta-triol (4). Metabolite 4 was identified as a new compound. These metabolites were structurally characterised on the basis of spectroscopic techniques.
Iqbal Choudhary
M
M
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan. hej@cyber.net.pk
Atif
M
M
Ur-Rahman
Atta
A
D003470:Culture Media; D020093:Cunninghamella / Q000378:metabolism*; D005285:Fermentation; D007202:Indicators and Reagents; D008234:Lynestrenol / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D003470:Culture Media; D007202:Indicators and Reagents; D008234:Lynestrenol