title: Hyperammonemic encephalopathy: a rare presentation of fibrolamellar hepatocellular carcinoma.
abstract: Fibrolamellar carcinoma (FLC) is a rare malignant hepatocellular tumor of unknown etiology, arising almost exclusively from noninfected, noncirrhotic liver of young adults. FLC has traditionally been considered to have better survival than hepatocellular carcinoma; however, this notion might be highly erroneous. Patients with metastatic disease at presentation have a dismal prognosis with 5-year survival of only 15%. We describe a case of highly aggressive metastatic FLC that presented as hyperammonemic encephalopathy, which has never been previously reported in the literature.
authors.affiliation: Department of Internal Medicine, Wayne State University/Detroit Medical Center, Detroit, Michigan, USA.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Sethi
authors.forename: Nishant
authors.initials: N
authors.lastname: Tageja
authors.forename: Jatinder
authors.initials: J
authors.lastname: Singh
authors.forename: Haitham
authors.initials: H
authors.lastname: Arabi
authors.forename: Maneesh
authors.initials: M
authors.lastname: Dave
authors.forename: Apurva
authors.initials: A
authors.lastname: Badheka
authors.forename: Sanjay
authors.initials: S
authors.lastname: Revankar
mesh_terms: D000293:Adolescent; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000473:pathology / Q000556:secondary; D006801:Humans; D022124:Hyperammonemia / Q000209:etiology*; D008113:Liver Neoplasms / Q000150:complications* / Q000473:pathology; D008297:Male; D020258:Neurotoxicity Syndromes / Q000209:etiology*