[Pulmonary embolism as a first manifestation of synchronous occurrence of two neoplasms].
A case of 67-year-old man with a first episode of acute, unprovoked venous thromboembolism (VTE). Screening for cancer revealed coexistence of two neoplasms: colon sigmoid cancer (operated on 6 weeks after pulmonary embolism onset), and multiple myeloma (treated successfully with thalidomide and dexamethasone). Low molecular weight heparin use as VTE treatment was followed by thromboprophylaxis for myeloma therapy. During a 30-month follow-up period, neither new thromboembolic complications nor cancer recurrence were observed. Overlapping different prothrombotic mechanisms of double malignancy might result in detection of both neoplasms at early stage.
Elikowski
Waldemar
W
Oddział Chorób Wewnetrznych, Szpital im. J. Strusia, Poznań. welikowski@wp.pl
Lewandowska
Maria
M
Małek
Małgorzata
M
Krokowicz
Piotr
P
Piotrowska-Stelmaszyk
Grazyna
G
Zawilska
Krystyna
K
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000150:complications* / Q000175:diagnosis*; D003907:Dexamethasone / Q000627:therapeutic use; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D016609:Neoplasms, Second Primary / Q000150:complications* / Q000175:diagnosis*; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000209:etiology*; D013792:Thalidomide / Q000627:therapeutic use; D016896:Treatment Outcome
D006495:Heparin, Low-Molecular-Weight; D013792:Thalidomide; D003907:Dexamethasone