[Cannabis-induced cerebral and myocardial infarction in a young woman].
BACKGROUND
Cannabis is the most consumed drug in the world particularly in young adults. Few reports have suggested a causal role of cannabis in the development of cerebral or cardiovascular events. We describe the first association of myocardial infarction and stroke after heavy cannabis consumption in a 45-year-old woman.


METHODS
Stroke occurred in relation with a right carotid and middle cerebral artery thrombosis after cannabis abuse. The patient was successfully treated with intravenous rt-PA. Two days after her admission, she presented a myocardial infarction due to a coronary thrombosis. Cerebral and coronary arteries were angiographically normal. Etiological tests were negative and a toxic cause in relation with cannabis consumption was concluded.


CONCLUSIONS
Cannabis can be associated with vascular events by different mechanisms. Thrombosis may occur in cerebral and/or coronary arteries. We suggest that it might be useful to search for cannabis consumption systematically in young subjects victims of stroke and myocardial infarction.
Duchene
C
C
Service de Neurologie, CHU Pierre-Zobda-Quitman, La Meynard, 97200 Fort-de-France, Martinique, France.
Olindo
S
S
Chausson
N
N
Jeannin
S
S
Cohen-Tenoudji
P
P
Smadja
D
D
D000925:Anticoagulants / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D002188:Cannabis / Q000009:adverse effects*; D002339:Carotid Arteries / Q000473:pathology; D002533:Cerebral Angiography; D002544:Cerebral Infarction / Q000139:chemically induced* / Q000473:pathology; D003328:Coronary Thrombosis / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000139:chemically induced / Q000473:pathology; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008385:Marijuana Smoking / Q000009:adverse effects*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000473:pathology; D020521:Stroke / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use
D000925:Anticoagulants; D010959:Tissue Plasminogen Activator