title: Analysis of DPP6 and FGGY as candidate genes for amyotrophic lateral sclerosis.
abstract: DPP6 and FGGY genes have been recently associated with an increased susceptibility for sporadic amyotrophic lateral sclerosis. Here, we evaluated the role of these genes in ALS pathogenesis by undertaking a sequence analysis of a cohort of 190 ALS patients from France and Quebec. We did not observe any evidence that mutations in DPP6 and FGGY genes are involved in ALS. Our data indicate that mutations in these genes are unlikely to be a common cause of ALS in the French and French Canadian populations.
authors.affiliation: Centre of Excellence in Neuromics, Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Hussein
authors.initials: H
authors.lastname: Daoud
authors.forename: Paul N
authors.initials: PN
authors.lastname: Valdmanis
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Dion
authors.forename: Guy A
authors.initials: GA
authors.lastname: Rouleau
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D002170:Canada; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015221:Potassium Channels / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D044465:White People
chemical_list: C547127:FGGY protein, human; D009419:Nerve Tissue Proteins; D015221:Potassium Channels; D011506:Proteins; C503535:DPP6 protein, human; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases