Emerging roles of ATF2 and the dynamic AP1 network in cancer.
Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Perspective summarizes our current understanding of the changes in members of the AP1 complex and the role of ATF2 as part of this complex in tumorigenesis.
Lopez-Bergami
Pablo
P
Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina. pablo.bergami@gmail.com
Lau
Eric
E
Ronai
Ze'ev
Z
D051698:Activating Transcription Factor 2 / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D053263:Gene Regulatory Networks; D006801:Humans; D005810:Multigene Family; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics / Q000378:metabolism; D018808:Transcription Factor AP-1 / Q000235:genetics / Q000378:metabolism*
D051698:Activating Transcription Factor 2; D016755:Proto-Oncogene Proteins c-jun; D018808:Transcription Factor AP-1