Thrombosis of abdominal aorta during cisplatin-based chemotherapy of testicular seminoma - a case report.
BACKGROUND
Vascular complications occurring during cisplatin-based chemotherapy of germ cell tumours are inadequately recognized to date.


METHODS
A 49 year old man with advanced seminoma underwent two courses of chemotherapy according to the PEB regimen. Upon restaging, two thrombotic deposits were noted in the descending part of the thoracic aorta and in the infrarenal abdominal aorta, respectively. Although thrombotic plaques caused aortic occlusion of about 30%, no clinical signs of malperfusion of limbs were registered. The patient was placed on anticoagulant therapy. Six months after completion of chemotherapy, thrombotic deposits had completely resolved. In the absence of other predisposing factors, it must be assumed that cisplatin-based chemotherapy represented a strong stimulus for arterial thrombosis in the aorta.


CONCLUSIONS
This is the first case of endo-aortic thrombosis during chemotherapy for testicular germ cell cancer. Providers of chemotherapy must be aware of arterial thrombosis even in young patients with testicular cancer.
Dieckmann
Klaus-Peter
KP
Department of Urology, Albertinen-Krankenhaus, Hamburg, Germany. DieckmannKP@t-online.de
Gehrckens
Ralf
R
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001012:Aorta, Abdominal / Q000473:pathology*; D001761:Bleomycin / Q000009:adverse effects; D002945:Cisplatin / Q000009:adverse effects; D004374:Ductus Arteriosus, Patent / Q000150:complications / Q000601:surgery; D005047:Etoposide / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D018239:Seminoma / Q000150:complications / Q000188:drug therapy*; D013736:Testicular Neoplasms / Q000150:complications / Q000188:drug therapy*; D013927:Thrombosis / Q000139:chemically induced*
D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin