Total synthesis of the anti-apoptotic agents iso- and bongkrekic acids.
The first convergent total synthesis of isobongkrekic acid is reported involving three different stereospecific palladium cross-couplings for the formation of the diene units. Access to bongkrekic acid by this route is also demonstrated. These syntheses involve the formation of several potentially general building blocks.
Francais
Antoine
A
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
Leyva
Antonio
A
Etxebarria-Jardi
Gorka
G
Ley
Steven V
SV
D017209:Apoptosis / Q000187:drug effects*; D001865:Bongkrekic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D008968:Molecular Conformation; D013237:Stereoisomerism
D001865:Bongkrekic Acid