Synthesis of fluorinated allenes via palladium-catalyzed monofluoromethylation using FBSM.
Palladium-catalyzed monofluoromethylation of substituted 2-bromo-1,3-dienes using fluorobis(phenylsulfonyl)methane (FBSM) as a pronucleophile gave previously unknown monofluoromethylated allenes in high yields, which are the isosteres of biologically attractive allenic alcohols.
Ogasawara
Masamichi
M
Catalysis Research Center and Graduate School of Life Science, Hokkaido University, Kita-ku, Sapporo 001-0021, Japan. ogasawar@cat.hokudai.ac.jp
Murakami
Hidetoshi
H
Furukawa
Tatsuya
T
Takahashi
Tamotsu
T
Shibata
Norio
N
D000466:Alkadienes / Q000138:chemical synthesis*; D017605:Bromine Compounds / Q000737:chemistry; D002384:Catalysis; D005461:Fluorine / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D000466:Alkadienes; D017605:Bromine Compounds; D006845:Hydrocarbons, Fluorinated; C546375:fluorobis(phenylsulfonyl)methane; D005461:Fluorine; C025947:propadiene; D010165:Palladium; D008697:Methane