The twisted side chain of antillatoxin is important for potent toxicity: total synthesis and biological evaluation of antillatoxin and analogues.
Okura
Ken
K
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Matsuoka
Shigeru
S
Goto
Ryosuke
R
Inoue
Masayuki
M
D000818:Animals; D002460:Cell Line; D000458:Cyanobacteria / Q000737:chemistry; D007202:Indicators and Reagents; D055666:Lipopeptides / Q000737:chemistry* / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D009498:Neurotoxins / Q000737:chemistry* / Q000633:toxicity*; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000633:toxicity*; D062687:Sodium Channel Agonists; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D055666:Lipopeptides; D009498:Neurotoxins; D010456:Peptides, Cyclic; D062687:Sodium Channel Agonists; C121886:antillatoxin