Peptoid-Peptide hybrid backbone architectures.
Peptidomimetic oligomers and foldamers have received considerable attention for over a decade, with beta-peptides and the so-called peptoids (N-alkylglycine oligomers) representing prominent examples of such architectures. Lately, hybrid or mixed backbones consisting of both alpha- and beta-amino acids (alpha/beta-peptides) have been investigated in some detail as well. The present Minireview is a survey of the literature concerning hybrid structures of alpha-amino acids and peptoids, including beta-peptoids (N-alkyl-beta-alanine oligomers), and is intended to give an overview of this area of research within the field of peptidomimetic science.
Olsen
Christian A
CA
Department of Medicinal Chemistry, University of Copenhagen, Universitetsparken 2, Copenhagen, 2100 Denmark. cao@farma.ku.dk caolsen@scripps.edu
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry; D020134:Catalytic Domain; D008024:Ligands; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D034444:Peptoids / Q000138:chemical synthesis / Q000737:chemistry*; D054730:Protein Interaction Domains and Motifs
D000596:Amino Acids; D023181:Antimicrobial Cationic Peptides; D008024:Ligands; D010455:Peptides; D034444:Peptoids