Development of renal and iliac aneurysms in a child with generalized infantile myofibromatosis.
Infantile myofibromatosis is a rare disorder characterized by the formation of tumors in the skin, soft tissues, bone, and viscera. We report the case of a 3-week-old girl who presented with severe hypertension due to generalized infantile myofibromatosis including renal involvement. The infant was treated by chemotherapy and showed progressive regression of the tumors. However, her evolution was marked by the development of aneurismal dilations of the renal and iliac arteries as observed in fibromuscular dysplasia. We discuss the possibility of a link between these two mesenchymal disorders.
Brasseur
Benoit
B
Department of Pediatric Hematology and Oncology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10, Brussels, Belgium.
Chantrain
Christophe F
CF
Godefroid
Nathalie
N
Sluysmans
Thierry
T
Anslot
Christine
C
Menten
Renaud
R
Clapuyt
Philippe
P
Dupont
Sophie
S
Vermylen
Christiane
C
Brichard
Bénédicte
B
D000783:Aneurysm / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D019917:Blood Vessel Prosthesis Implantation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D017543:Iliac Aneurysm / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D007231:Infant, Newborn; D018224:Myofibromatosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011859:Radiography; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000601:surgery; D012078:Renal Artery Obstruction / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D006435:Renal Dialysis; D016896:Treatment Outcome
D000970:Antineoplastic Agents