title: Synthesis and anti-HIV activity of [ddN]-[ddN] dimers and benzimidazole nucleoside dimers.
abstract: In an attempt to combine the HIV-inhibitory capacity of different 2',3'-dideoxynucleoside (ddN) analogs, we have designed and synthesized several dimers of [AZT]-[AZT] and [AZT]-[d4T]. In addition, we also synthesized the dimers of 1-(1H-benzimidazol-1-yl)-1-deoxy-beta-D-ribofuranose. The in vitro anti-HIV activity of these compounds on a pseudotype virus, pNL4-3.Luc.R-E-, in the 293T cells has been determined. Among these compounds, 2,2'-(propane-1,3-diyl)bis[1-(beta-D-ribofuranosyl)-1H-benzimidazole] showed the highest anti-HIV activity with similar effect as AZT.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P. R. China.
authors.forename: Guo-Rui
authors.initials: GR
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Qin
authors.initials: Q
authors.lastname: Pan
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Song
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Luo
authors.forename: Shao-Ru
authors.initials: SR
authors.lastname: Wang
authors.forename: Xiao-Lian
authors.initials: XL
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D015224:Dideoxynucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D019281:Dimerization; D016655:HIV Core Protein p24 / Q000378:metabolism; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015215:Zidovudine / Q000737:chemistry
chemical_list: C547372:2,2'-(propane-1,3-diyl)bis(1-(ribofuranosyl)-1H-benzimidazole); D019380:Anti-HIV Agents; D001562:Benzimidazoles; D015224:Dideoxynucleosides; D016655:HIV Core Protein p24; D009705:Nucleosides; D015215:Zidovudine; C031000:benzimidazole