title: A mixture of peptides and sugars derived from plant cell walls increases plant defense responses to stress and attenuates ageing-associated molecular changes in cultured skin cells.
abstract: Small peptides and aminoacid derivatives have been extensively studied for their effect of inducing plant defense responses, and thus increasing plant tolerance to a wide range of abiotic stresses. Similarly to plants, these compounds can activate different signaling pathways in mammalian skin cells as well, leading to the up-regulation of anti-aging specific genes. This suggests the existence of analogous defense response mechanisms, well conserved both in plants and animal cells. In this article, we describe the preparation of a new mixture of peptides and sugars derived from the chemical and enzymatic digestion of plant cell wall glycoproteins. We investigate the multiple roles of this product as potential "biostimulator" to protect plants from abiotic stresses, and also as potential cosmeceutical. In particular, the molecular effects of the peptide/sugar mixture of inducing plant defense responsive genes and protecting cultured skin cells from oxidative burst damages were deeply evaluated.
authors.affiliation: Arterra Bioscience, via Brin 69, 80142 Napoli, Italy. fapone@arterrabio.it
authors.forename: Fabio
authors.initials: F
authors.lastname: Apone
authors.forename: Annalisa
authors.initials: A
authors.lastname: Tito
authors.forename: Antonietta
authors.initials: A
authors.lastname: Carola
authors.forename: Stefania
authors.initials: S
authors.lastname: Arciello
authors.forename: Assunta
authors.initials: A
authors.lastname: Tortora
authors.forename: Lucio
authors.initials: L
authors.lastname: Filippini
authors.forename: Irene
authors.initials: I
authors.lastname: Monoli
authors.forename: Mirna
authors.initials: M
authors.lastname: Cucchiara
authors.forename: Simone
authors.initials: S
authors.lastname: Gibertoni
authors.forename: Maarten J
authors.initials: MJ
authors.lastname: Chrispeels
authors.forename: Gabriella
authors.initials: G
authors.lastname: Colucci
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D017360:Arabidopsis / Q000187:drug effects / Q000235:genetics / Q000276:immunology*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D002241:Carbohydrates / Q000494:pharmacology*; D002473:Cell Wall / Q000737:chemistry* / Q000187:drug effects; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000187:drug effects; D003094:Collagen / Q000378:metabolism; D020552:Comet Assay; D018506:Gene Expression Regulation, Plant / Q000187:drug effects; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000201:enzymology; D013058:Mass Spectrometry; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism; D051379:Mice; D041681:NIH 3T3 Cells; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012867:Skin / Q000166:cytology*; D013312:Stress, Physiological / Q000187:drug effects*; D014026:Nicotiana / Q000166:cytology* / Q000187:drug effects
chemical_list: D000975:Antioxidants; D029681:Arabidopsis Proteins; D002241:Carbohydrates; D010455:Peptides; D017382:Reactive Oxygen Species; D003094:Collagen; D020782:Matrix Metalloproteinases