Virological and cellular roles of the transcriptional coactivator LEDGF/p75.
The chromatin-associated cellular proteins LEDGF/p75 and LEDGF/p52 have been implicated in transcriptional regulation, cell survival and autoimmunity. LEDGF/p75 also appears to act as a chromatin-docking factor or receptor for HIV-1 and other lentiviruses and to play a role in leukemogenesis. For both the viral and cellular roles of this protein, a key feature is its ability to act as a molecular adaptor and tether proteins to the chromatin fiber. This chapter reviews the emerging roles of LEDGF/p75 and LEDGF/p52 in diverse cellular processes and disease states.
Llano
Manuel
M
Biological Sciences Department, University of Texas, El Paso, TX 79968-0519, USA. mllano@utep.edu
Morrison
James
J
Poeschla
Eric M
EM
D000595:Amino Acid Sequence; D000818:Animals; D002470:Cell Survival; D002843:Chromatin / Q000378:metabolism; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D014158:Transcription, Genetic
D002843:Chromatin; D036341:Intercellular Signaling Peptides and Proteins; C119380:lens epithelium-derived growth factor