title: Electrostatic interactions affect nanoparticle-mediated toxicity to gram-negative bacterium Pseudomonas aeruginosa PAO1.
abstract: Nanoscale materials can have cytotoxic effects. Here we present the first combined empirical and theoretical investigation of the influence of electrostatic attraction on nanoparticle cytotoxicity. Modeling electrostatic interactions between cells and 13 nm spheres of zinc oxide nanoparticles provided insight into empirically determined variations of the minimum inhibitory concentrations between four differently charged isogenic strains of Pseudomonas aeruginosa PAO1. We conclude that controlling the electrostatic attraction between nanoparticles and their cellular targets may permit the modulation of nanoparticle cytotoxicity.
authors.affiliation: Department of Biology, Boise State University, Boise, Idaho 83725, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Feris
authors.forename: Caitlin
authors.initials: C
authors.lastname: Otto
authors.forename: Juliette
authors.initials: J
authors.lastname: Tinker
authors.forename: Denise
authors.initials: D
authors.lastname: Wingett
authors.forename: Alex
authors.initials: A
authors.lastname: Punnoose
authors.forename: Aaron
authors.initials: A
authors.lastname: Thurber
authors.forename: Madhu
authors.initials: M
authors.lastname: Kongara
authors.forename: Maryam
authors.initials: M
authors.lastname: Sabetian
authors.forename: Bonnie
authors.initials: B
authors.lastname: Quinn
authors.forename: Charles
authors.initials: C
authors.lastname: Hanna
authors.forename: David
authors.initials: D
authors.lastname: Pink
mesh_terms: D006860:Hydrogen Bonding; D008962:Models, Theoretical; D053758:Nanoparticles; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D055672:Static Electricity