Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging.
In the domain of health, one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers. Most of the existing carrier materials show poor drug loading (usually less than 5 wt% of the transported drug versus the carrier material) and/or rapid release of the proportion of the drug that is simply adsorbed (or anchored) at the external surface of the nanocarrier. In this context, porous hybrid solids, with the ability to tune their structures and porosities for better drug interactions and high loadings, are well suited to serve as nanocarriers for delivery and imaging applications. Here we show that specific non-toxic porous iron(III)-based metal-organic frameworks with engineered cores and surfaces, as well as imaging properties, function as superior nanocarriers for efficient controlled delivery of challenging antitumoural and retroviral drugs (that is, busulfan, azidothymidine triphosphate, doxorubicin or cidofovir) against cancer and AIDS. In addition to their high loadings, they also potentially associate therapeutics and diagnostics, thus opening the way for theranostics, or personalized patient treatments.
Horcajada
Patricia
P
Institut Lavoisier (CNRS 8180) Institut universitaire de France, Université de Versailles, 78035 Versailles Cedex, France. horcajada@chimie.uvsq.fr
Chalati
Tamim
T
Serre
Christian
C
Gillet
Brigitte
B
Sebrie
Catherine
C
Baati
Tarek
T
Eubank
Jarrod F
JF
Heurtaux
Daniela
D
Clayette
Pascal
P
Kreuz
Christine
C
Chang
Jong-San
JS
Hwang
Young Kyu
YK
Marsaud
Veronique
V
Bories
Phuong-Nhi
PN
Cynober
Luc
L
Gil
Sophie
S
Férey
Gérard
G
Couvreur
Patrick
P
Gref
Ruxandra
R
D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D003952:Diagnostic Imaging; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D005260:Female; D006801:Humans; D008264:Macrophages / Q000187:drug effects; D008279:Magnetic Resonance Imaging; D051379:Mice; D049329:Nanostructures / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D010316:Particle Size; D016062:Porosity; D051381:Rats
D003287:Contrast Media; D004337:Drug Carriers; D009942:Organometallic Compounds