title: [Prospects for pharmacological regulation of macrophage activity by modulation of intracellular signal cascade].
abstract: This article is devoted to classical and alternative macrophage activation, and intracellular transmission of external signals onto genes. It presents data on postreceptor events resulting in the formation of classical or alternative properties of macrophages. The role of some molecules of intracellular signaling pathways (STAT1, NF-kappaB, IRAK, TRAF6, Jak1, Tyk2, STAT3, c-Maf, Sp1, C/EBP, CREB, STAT6, MAP-kinase, PI3-kinase, c P) in the development of proinflammatory and anti-inflammatory activities of macrophages is discussed.
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Bel'skiĭ
authors.forename: N V
authors.initials: NV
authors.lastname: Bel'skaia
authors.forename: M G
authors.initials: MG
authors.lastname: Danilets
authors.forename: E S
authors.initials: ES
authors.lastname: Trofimova
authors.forename: E G
authors.initials: EG
authors.lastname: Uchasova
authors.forename: A A
authors.initials: AA
authors.lastname: Ligacheva
authors.forename: V I
authors.initials: VI
authors.lastname: Agafonov
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D016207:Cytokines / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D047908:Intracellular Signaling Peptides and Proteins / Q000187:drug effects* / Q000378:metabolism; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D016207:Cytokines; D047908:Intracellular Signaling Peptides and Proteins; D047428:Protein Kinase Inhibitors