Influence of megestrol acetate on nutrition and inflammation in dialysis patients - preliminary results.
Malnutrition is a common clinical problem in dialysis patients. So far the management of malnutrition in this population has not been fully successful. The aim of the study was to evaluate the efficacy and safety of use of megestrol acetate suspension in malnourished dialysis patients. Twenty-six hypoalbuminemic (albumin < or = 3.8 g/dl) dialysis patients took 160 mg of megestrol acetate daily for a period of two months. Anthropometry (dry weight, body mass index) and biochemical measurements of nutrition (serum albumin, triglycerides, total cholesterol) and inflammation (hsCRP, IL-1beta, IL-6) were performed on a monthly basis. The treatment led to a statistically significant increase (P < 0.05) in anthropometry and albumin concentration, with no statistically significant changes in total cholesterol, triglycerides and indices of inflammation. Side effects included overhydration, diarrhoea and hyperglycaemia. Thus, megestrol acetate may be an effective therapeutic agent in improving the nutritional status of carefully selected dialysis patients, while it might not mitigate inflammation. Because of the prevalent side effects it must be monitored closely.
Gołebiewska
Justyna
J
Palliative Medicine Department, Medical University of Gdańsk, Gdańsk, Poland. jgolebiewska@gumed.edu.pl
Lichodziejewska-Niemierko
Monika
M
Aleksandrowicz
Ewa
E
Majkowicz
Mikołaj
M
Lysiak-Szydłowska
Wiesława
W
Rutkowski
Bolesław
B
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D044342:Malnutrition / Q000188:drug therapy* / Q000209:etiology; D019290:Megestrol Acetate / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D009752:Nutritional Status; D006435:Renal Dialysis / Q000009:adverse effects*; D012709:Serum Albumin / Q000187:drug effects / Q000378:metabolism
D012709:Serum Albumin; D019290:Megestrol Acetate