Psoriasis induced by losartan therapy: a case report and review of the literature.
Psoriasis is a papulosquamous disease of multifactorial etiology. A combination of genetic and environmental agents is implicated in its pathogenesis. A variety of triggers, including infection, stress, and medications, have been recognized as precipitants of this disease. Nonsteroidal anti-inflammatory drugs, beta-blockers, lithium, synthetic antimalarials, and gold are the most common drugs implicated in precipitating psoriasis. We report a patient with psoriasis induced by initiation of losartan therapy, which resolved with discontinuation of the drug. The Naranjo adverse drug reaction probability scale score indicated that the association between losartan use and psoriasis was probable.
Lamba
Gurpreet
G
Department of Medicine, New York Medical College, Valhalla, USA.
Palaniswamy
Chandrasekar
C
Singh
Tarunjit
T
Shah
Dhaval
D
Lal
Sonia
S
Vinnakota
Ravi
R
Charrow
Elliott J
EJ
Forman
Leanne
L
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000494:pharmacology; D047228:Angiotensin II Type 1 Receptor Blockers / Q000009:adverse effects* / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology; D000962:Antimalarials / Q000009:adverse effects / Q000494:pharmacology; D018692:Antimanic Agents / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D008094:Lithium / Q000009:adverse effects; D019808:Losartan / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy
D000319:Adrenergic beta-Antagonists; D047228:Angiotensin II Type 1 Receptor Blockers; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000962:Antimalarials; D018692:Antimanic Agents; D008094:Lithium; D019808:Losartan