InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared.
We present the synthesis of InAs quantum dots (QDs) with a ZnCdS shell with bright and stable emission in the near-infrared (NIR, 700-900 nm) region for biological imaging applications. We demonstrate how NIR QDs can image tumor vasculature in vivo at significantly deeper penetration depths and with higher contrast than visible emitting CdSe(CdS) QDs. Targeted cellular labeling is also presented and may enable multiplexed and low autofluorescence cellular imaging.
Allen
Peter M
PM
Massachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Liu
Wenhao
W
Chauhan
Vikash P
VP
Lee
Jungmin
J
Ting
Alice Y
AY
Fukumura
Dai
D
Jain
Rakesh K
RK
Bawendi
Moungi G
MG
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007204:Indium / Q000737:chemistry*; D007259:Infrared Rays; D008670:Metals / Q000737:chemistry*; D051379:Mice; D057054:Molecular Imaging / Q000379:methods*; D045663:Quantum Dots; D012680:Sensitivity and Specificity; D015032:Zinc / Q000737:chemistry*
D001672:Biocompatible Materials; D008670:Metals; D007204:Indium; D015032:Zinc