title: Stereotactic body radiotherapy for isolated paraaortic lymph node recurrence from colorectal cancer.
abstract: OBJECTIVE
  To evaluate the efficacy and complications of stereotactic body radiotherapy in localized paraaortic lymph node recurrence from colorectal cancer.
  
  
  METHODS
  From 2003 to 2009, 7 patients with paraaortic lymph node recurrence (1-3 lesions) from colorectal cancer were treated with stereotactic body radiotherapy. Total gross tumor volumes ranged from 4 to 40 mL. The doses were escalated from 36 Gy/patient to 51 Gy/patient and were delivered in 3 fractions.
  
  
  RESULTS
  One and 3 year overall survival rates were 100% and 71.4%, respectively, and median survival was 37 mo. Grade IV intestinal obstruction was reported in 1 of 7 patients. This patient received 48 Gy in 3 fractions with a maximum point dose to the intestine of 53 Gy and V(45Gy) = 3.6 mL. However, 6 patients received an intestinal maximum point dose of < 51 Gy and V(45Gy) of < 1 mL, and did not develop any severe complications.
  
  
  CONCLUSIONS
  This pilot study suggests selected paraaortic lymph node recurrence (1-3 closed lesions) that failed to respond to chemotherapy can be potentially salvaged by stereotactic body radiotherapy.
authors.affiliation: Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, 215-4 Gongneung-dong, Nowon-gu, Seoul 139-706, South Korea. mskim@kcch.re.kr
authors.forename: Mi-Sook
authors.initials: MS
authors.lastname: Kim
authors.forename: Chul Koo
authors.initials: CK
authors.lastname: Cho
authors.forename: Kwang Mo
authors.initials: KM
authors.lastname: Yang
authors.forename: Dong Han
authors.initials: DH
authors.lastname: Lee
authors.forename: Sun Mi
authors.initials: SM
authors.lastname: Moon
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Shin
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy* / Q000601:surgery; D000368:Aged; D001011:Aorta; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy* / Q000601:surgery; D010865:Pilot Projects; D016634:Radiosurgery; D012004:Rectal Neoplasms / Q000473:pathology*; D012189:Retrospective Studies