Wnt modulators in the biotech pipeline.
The purpose of this review is to provide a better understanding for the LRP co-receptor-mediated Wnt pathway signaling. Using proteomics, we have also subdivided the LRP receptor family into six sub-families, encompassing the twelve family members. This review includes a discussion of proteins containing a cystine-knot protein motif (i.e., Sclerostin, Dan, Sostdc1, Vwf, Norrin, Pdgf, Mucin) and discusses how this motif plays a role in mediating Wnt signaling through interactions with LRP.
Rey
Jean-Philippe
JP
OsteoGeneX Inc., Kansas City, Kansas 66160, USA.
Ellies
Debra L
DL
D000595:Amino Acid Sequence; D001709:Biotechnology / Q000639:trends*; D047168:Cystine Knot Motifs / Q000235:genetics / Q000502:physiology*; D026502:LDL-Receptor Related Proteins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D008024:Ligands; D008958:Models, Molecular; D008969:Molecular Sequence Data; D040901:Proteomics; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins / Q000378:metabolism*
D026502:LDL-Receptor Related Proteins; D008024:Ligands; D051153:Wnt Proteins