title: FDG-PET-CT for staging of high-risk breast cancer patients reduces the number of further examinations: A pilot study.
abstract: OBJECTIVE
  To determine the additional value of FDG-PET-CT as compared to conventional staging (CS) in high-risk breast cancer patients.
  
  
  METHODS
  Thirty-one high-risk breast cancer patients, 14 of whom had recurrent breast cancer, were included in this study, which took place between June 2005 and March 2008. None of the patients had clinical signs of distant metastases. FDG-PET-CT scanning was added to CS, which consisted of a chest x-ray, liver ultrasonography or CT, and bone scintigraphy. Median follow-up was 17 months (6-41 months). FDG-PET-CT was considered to have additional value to CS if it led to a change in treatment plan or if it made additional examinations to confirm or deny findings on CS unnecessary.
  
  
  RESULTS
  FDG-PET-CT was considered to have additional value to CS in 13 patients (42% [95% CI: 23-61]). In five patients (16% [95% CI: 1-31]), FDG-PET-CT led to a change in treatment plan by identifying nodal metastases in the internal mammary chain (IMC; N = 3) or in the mediastinum (N = 2). In nine patients (29% [95% CI: 11-47]), FDG-PET-CT would have prevented the need for additional examinations; in seven of these nine patients, distant metastases were suggested in bone or liver on CS, but these did not show FDG uptake.
  
  
  CONCLUSIONS
  FDG-PET-CT was found to have additional value to CS in 42% of the patients. To optimize cost-effectiveness, the main challenge now is to improve the selection of patients in whom FDG-PET-CT has additional value to CS.
authors.affiliation: MAASTRO Clinic, Department of Radiation Oncology, 6202 NA Maastricht, The Netherlands. jos.jager@maastro.nl
authors.forename: Jos J
authors.initials: JJ
authors.lastname: Jager
authors.forename: Kristien
authors.initials: K
authors.lastname: Keymeulen
authors.forename: Regina G H
authors.initials: RG
authors.lastname: Beets-Tan
authors.forename: Pierre
authors.initials: P
authors.lastname: Hupperets
authors.forename: Marinus
authors.initials: M
authors.lastname: van Kroonenburgh
authors.forename: Ruud
authors.initials: R
authors.lastname: Houben
authors.forename: Dirk
authors.initials: D
authors.lastname: de Ruysscher
authors.forename: Philippe
authors.initials: P
authors.lastname: Lambin
authors.forename: Liesbeth J
authors.initials: LJ
authors.lastname: Boersma
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D009367:Neoplasm Staging / Q000379:methods*; D010865:Pilot Projects; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18