title: The role of sentinel lymph node biopsy in differentiated thyroid carcinoma.
abstract: OBJECTIVE
  To determine whether sentinel lymph node (SLN) biopsy can accurately predict central compartment metastasis in patients with differentiated thyroid carcinoma.
  
  
  METHODS
  Prospective clinical study.
  
  
  METHODS
  Academic tertiary care center.
  
  
  METHODS
  Ninety-eight patients (82 women and 16 men; mean age, 48.3 years) underwent a total thyroidectomy and central compartment dissection.
  
  
  METHODS
  Peritumoral injection of methylene blue dye, 1%, followed by SLN biopsy.
  
  
  METHODS
  The final pathology report established the presence of metastasis among SLNs and lymph nodes that did not stain blue (non-SLNs [NSLNs]).
  
  
  RESULTS
  Differentiated thyroid carcinoma was found in 75 of 98 patients (77%). Seventy of 75 patients with differentiated thyroid carcinoma presented with SLNs and/or NSLNs within the central compartment. Fifteen of 70 patients had metastasis-positive SLNs, while 55 had metastasis-negative SLNs. Six of 15 patients with positive SLNs also had positive NSLNs. No patients with negative SLNs were found to have positive NSLNs. Sentinal lymph node status was a highly significant predictor of NSLN result (Fisher exact test, P < .001). The accuracy, sensitivity, specificity, and positive and negative predictive values of SLN biopsy were 87%, 100%, 86%, 40%, and 100%, respectively.
  
  
  CONCLUSIONS
  To our knowledge, this is the largest series of SLN biopsy in patients with differentiated thyroid carcinoma. Our experience suggests that this is an accurate and noninvasive means to identify subclinical lymph node metastasis. Because negative SLNs correlate strongly with a negative central compartment (100% in this study, P < .001), this technique can be used as an intraoperative guide when determining the extent of surgery necessary in cervical level VI.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Jewish General Hospital, 3755 Chemin de la Cote-Ste-Catherine Road, Montreal, QC, Canada.
authors.forename: Sumeet M
authors.initials: SM
authors.lastname: Anand
authors.forename: Olga
authors.initials: O
authors.lastname: Gologan
authors.forename: Louise
authors.initials: L
authors.lastname: Rochon
authors.forename: Michael
authors.initials: M
authors.lastname: Tamilia
authors.forename: Jacques
authors.initials: J
authors.lastname: How
authors.forename: Michael P
authors.initials: MP
authors.lastname: Hier
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Black
authors.forename: Keith
authors.initials: K
authors.lastname: Richardson
authors.forename: Hadi A
authors.initials: HA
authors.lastname: Hakami
authors.forename: Hani Z
authors.initials: HZ
authors.lastname: Marzouki
authors.forename: Mark
authors.initials: M
authors.lastname: Trifiro
authors.forename: Roger
authors.initials: R
authors.lastname: Tabah
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Payne
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011237:Predictive Value of Tests; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery