title: Advanced metastatic melanoma during pregnancy: a multidisciplinary challenge.
abstract: BACKGROUND
  Metastatic melanoma during pregnancy represents a life-threatening situation not only for the mother but also for the fetus due to aggressive therapy and potential maternal-fetal metastasis.
  
  
  METHODS
  We report the case of a 37-year-old woman with advanced metastatic malignant melanoma during her first pregnancy, with a review of the literature. In this case, a tight and primarily interdisciplinary obstetrical and dermatological case management enabled the delivery of a small but healthy premature infant in the 29th week of gestation by planned Cesarean section. However, due to progressive disease, the mother died only 10 weeks after the delivery of the baby.
  
  
  CONCLUSIONS
  Sufficient perinatal and oncologic experience provided, diagnostic and surgical interventions as well as radiotherapy and chemotherapy in metastatic melanoma disease are feasible and relatively safe even during pregnancy.
authors.affiliation: Frauenklinik (OB/GYN), Technische Universität München, München, Germany. nina.gottschalk@uk-koeln.de
authors.forename: Nina
authors.initials: N
authors.lastname: Gottschalk
authors.forename: Volker R
authors.initials: VR
authors.lastname: Jacobs
authors.forename: Ruediger
authors.initials: R
authors.lastname: Hein
authors.forename: Thorsten
authors.initials: T
authors.lastname: Fischer
authors.forename: Karl T M
authors.initials: KT
authors.lastname: Schneider
authors.forename: Stephanie
authors.initials: S
authors.lastname: Pildner von Steinburg
mesh_terms: D000328:Adult; D005260:Female; D005858:Germany; D006801:Humans; D008545:Melanoma / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy*; D010348:Patient Care Team; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis* / Q000628:therapy*; D016896:Treatment Outcome