title: The cardiovascular effects of normobaric hyperoxia in patients with heart rate fixed by permanent pacemaker.
abstract: To investigate whether the established reductions in heart rate and cardiac output with hyperoxia in humans are primary effects or secondary to increases in systemic vascular resistance, we paced the hearts of nine patients with permanent pacemakers at a fixed rate when breathing either medical air (inspired O(2) fraction 0.21) or oxygen (inspired O(2) fraction 0.80) in a randomised, double-blind fashion. A thoracic bio-impedance machine was used to measure heart rate, stroke volume and blood pressure and calculate cardiac index and systemic vascular resistance index. Oxygen caused no change in cardiac index (p = 0.18), stroke index (p = 0.44) or blood pressure (p = 0.52) but caused a small (5.5%) increase in systemic vascular resistance index (p = 0.03). This suggests that hyperoxia has no direct myocardial depressant effects, but that the changes in cardiac output reported in previous studies are secondary to changes in systemic vascular resistance.
authors.affiliation: Department of Anaesthesia, University of Glasgow, Glasgow, UK. keithanderson@doctors.net.uk
authors.forename: K J
authors.initials: KJ
authors.lastname: Anderson
authors.forename: J M
authors.initials: JM
authors.lastname: Harten
authors.forename: M G
authors.initials: MG
authors.lastname: Booth
authors.forename: C
authors.initials: C
authors.lastname: Berry
authors.forename: A
authors.initials: A
authors.lastname: McConnachie
authors.forename: A C
authors.initials: AC
authors.lastname: Rankin
authors.forename: J
authors.initials: J
authors.lastname: Kinsella
mesh_terms: D000328:Adult; D000368:Aged; D002302:Cardiac Output / Q000187:drug effects / Q000502:physiology; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000494:pharmacology*; D010102:Oxygen Inhalation Therapy; D010138:Pacemaker, Artificial; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology; D055815:Young Adult
chemical_list: D010100:Oxygen