title: Coordination to gallium(III) strongly enhances the potency of 2-pyridineformamide thiosemicarbazones against Cryptococcus opportunistic fungi.
abstract: A family of 2-pyridineformamide-derived thiosemicarbazones and their gallium(III) complexes were tested against several isolates of pathogenic Cryptococcus strains. On complexation the antifungal activity significantly increases, suggesting coordination to gallium(III) to be an interesting strategy of antifungal dose reduction.
authors.affiliation: Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN), CP 941, 31161-970 Belo Horizonte, Brazil.
authors.forename: Thaíssa de Oliveira
authors.initials: Tde O
authors.lastname: Bastos
authors.forename: Betânia Maria
authors.initials: BM
authors.lastname: Soares
authors.forename: Patrícia Silva
authors.initials: PS
authors.lastname: Cisalpino
authors.forename: Isolda Castro
authors.initials: IC
authors.lastname: Mendes
authors.forename: Raquel Gouvea
authors.initials: RG
authors.lastname: dos Santos
authors.forename: Heloisa
authors.initials: H
authors.lastname: Beraldo
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D003453:Cryptococcosis / Q000382:microbiology; D003454:Cryptococcus / Q000187:drug effects*; D004357:Drug Synergism; D005559:Formamides / Q000494:pharmacology*; D005708:Gallium / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000494:pharmacology*; D013882:Thiosemicarbazones / Q000494:pharmacology*
chemical_list: C532279:2-pyridineformamide; D000935:Antifungal Agents; D005559:Formamides; D011725:Pyridines; D013882:Thiosemicarbazones; D005708:Gallium