title: Outcomes of transplantation of single pediatric renal allografts equal to or more than 6 cm in length.
abstract: BACKGROUND
  Because of the donor organ shortage, kidneys from smaller pediatric donors are being increasingly used. However, it is unclear whether small pediatric deceased donor kidneys should be used as single grafts or en bloc. We reviewed our outcomes of single kidney transplants from small pediatric donors into adult recipients.
  
  
  METHODS
  Kidneys equal to or more than 6 cm in length were transplanted as a single kidney in seven adult recipients weighing less than 80 kg. Creatinine clearance, kidney graft size, and glomerular size were followed up at 1, 3, 6, and 12 months after transplantation.
  
  
  RESULTS
  All patients and grafts, with the exception of one patient, are currently alive with functional grafts. Two kidneys were procured after cardiac death of the donors, but no delayed graft function was observed. A total of 57% (four of seven) patients developed BK viremia, and 29% (two of seven) patients developed BK virus nephropathy. The graft size significantly increased during follow-up by ultrasonography (P=0.02). The renal allograft function by calculated creatinine clearance also significantly improved at 40.6+/-6.9 mL/min, 52.7+/-10.2 mL/min, and 66.2+/-9.7 mL/min at 1, 3, and 12 month after transplantation, respectively (P=0.01). The size of glomeruli significantly increased from 122+/-8.4 mum at 1 to 2 months to 169+/-22.5 mum at 3 to 12 months after transplantation (P<0.01).
  
  
  CONCLUSIONS
  Kidneys equal to or more than 6 cm from small pediatric donors can be successfully transplanted as a single kidney. Single pediatric kidney transplantation can provide adequate renal function with a speedy increase in allograft size.
authors.affiliation: Division of Transplantation, Department of Surgery, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA.
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Uemura
authors.forename: John
authors.initials: J
authors.lastname: Liang
authors.forename: Akhtar
authors.initials: A
authors.lastname: Khan
authors.forename: Osun
authors.initials: O
authors.lastname: Kwon
authors.forename: Nasrollah
authors.initials: N
authors.lastname: Ghahramani
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Hollenbeak
authors.forename: Brian W
authors.initials: BW
authors.lastname: Reeves
authors.forename: Zakiyah
authors.initials: Z
authors.lastname: Kadry
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D019992:Databases as Topic; D006085:Graft Survival; D006801:Humans; D007223:Infant; D007668:Kidney / Q000254:growth & development / Q000378:metabolism / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects; D009929:Organ Size; D013997:Time Factors; D014019:Tissue Donors / Q000600:supply & distribution*; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D003404:Creatinine