title: A new prior for bayesian anomaly detection: application to biosurveillance.
abstract: OBJECTIVE
  Bayesian anomaly detection computes posterior probabilities of anomalous events by combining prior beliefs and evidence from data. However, the specification of prior probabilities can be challenging. This paper describes a Bayesian prior in the context of disease outbreak detection. The goal is to provide a meaningful, easy-to-use prior that yields a posterior probability of an outbreak that performs at least as well as a standard frequentist approach. If this goal is achieved, the resulting posterior could be usefully incorporated into a decision analysis about how to act in light of a possible disease outbreak.
  
  
  METHODS
  This paper describes a Bayesian method for anomaly detection that combines learning from data with a semi-informative prior probability over patterns of anomalous events. A univariate version of the algorithm is presented here for ease of illustration of the essential ideas. The paper describes the algorithm in the context of disease-outbreak detection, but it is general and can be used in other anomaly detection applications. For this application, the semi-informative prior specifies that an increased count over baseline is expected for the variable being monitored, such as the number of respiratory chief complaints per day at a given emergency department. The semi-informative prior is derived based on the baseline prior, which is estimated from using historical data.
  
  
  RESULTS
  The evaluation reported here used semi-synthetic data to evaluate the detection performance of the proposed Bayesian method and a control chart method, which is a standard frequentist algorithm that is closest to the Bayesian method in terms of the type of data it uses. The disease-outbreak detection performance of the Bayesian method was statistically significantly better than that of the control chart method when proper baseline periods were used to estimate the baseline behavior to avoid seasonal effects. When using longer baseline periods, the Bayesian method performed as well as the control chart method. The time complexity of the Bayesian algorithm is linear in the number of the observed events being monitored, due to a novel, closed-form derivation that is introduced in the paper.
  
  
  CONCLUSIONS
  This paper introduces a novel prior probability for Bayesian outbreak detection that is expressive, easy-to-apply, computationally efficient, and performs as well or better than a standard frequentist method.
authors.affiliation: Lister Hill National Center for Biomedical Communications, Building 38A, 9N912A, National Institute of Health, Bethesda, Maryland 20894, USA. yanna.shen@nih.gov
authors.forename: Y
authors.initials: Y
authors.lastname: Shen
authors.forename: G F
authors.initials: GF
authors.lastname: Cooper
mesh_terms: D000465:Algorithms; D000881:Anthrax / Q000453:epidemiology; D001499:Bayes Theorem; D055877:Biosurveillance / Q000379:methods*; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data; D005189:False Positive Reactions; D006801:Humans; D016011:Normal Distribution; D009716:Numerical Analysis, Computer-Assisted; D011338:Probability Theory; D015203:Reproducibility of Results