title: Reduced serum vaspin concentrations in obese children following short-term intensive lifestyle modification.
abstract: BACKGROUND
  Recently, visceral adipose tissue-derived serpin (vaspin) was identified as a potential insulin sensitizing adipokine, however, the factors determining the levels of circulating vaspin levels have not been fully understood. We investigated the association between adiposity, insulin resistance, lipid profiles and inflammatory markers including vaspin levels, and the effects of short-term intensive lifestyle modification on circulating vaspin levels in overweight or obese children.
  
  
  METHODS
  A total of 50 (25 boys, 25 girls) overweight or obese children aged 11 to 13 years (average age: 12.0+/-0.9 y, BMI: 25.35+/-86 kg/m(2)) who complied with inclusion criteria participated in our study. To determine the association between adiposity, insulin resistance, lipid profiles and inflammatory markers including vaspin levels, cross-sectional analyses were performed. Thereafter, subjects underwent a tightly controlled seven-day intensive lifestyle modification including physical activity, dietary modification, and behavioral modification education in residence of a local university dormitory.
  
  
  RESULTS
  There was a negative correlation between vaspin concentration and fasting insulin (r=-.325, p<0.05) and homeostasis model assessment of insulin resistance (HOMA-IR) (r=-.331, p<0.05) when percent body fat was controlled. Multivariate linear regression analysis found serum vaspin level to be an independent predictor of insulin and HOMA-IR. Short-term intensive lifestyle modification significantly decreased vaspin levels by 39.28% (pre: .84+/-1.0, post: .51+/-1.0 ng/ml, p<0.001) while adiponectin levels increased by 11.2% (pre: 6.50+/-2.89, post: 7.28+/-2.98 ng/ml, p<0.01). In addition, short-term lifestyle modification significantly improved HOMA-IR (pre: 3.58+/-1.93, post 1.30+/-1.9, p<0.001) and lipid profiles.
  
  
  CONCLUSIONS
  Serum vaspin level is one of the predictors for insulin resistance and was significantly reduced following short-term lifestyle modification.
authors.affiliation: Department of Sport and Leisure Studies, Yonsei University, Seoul, Republic of Korea.
authors.forename: Mi Kyung
authors.initials: MK
authors.lastname: Lee
authors.forename: Yoonsuk
authors.initials: Y
authors.lastname: Jekal
authors.forename: Jee-Aee
authors.initials: JA
authors.lastname: Im
authors.forename: Eunsung
authors.initials: E
authors.lastname: Kim
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Lee
authors.forename: Ji-Hye
authors.initials: JH
authors.lastname: Park
authors.forename: Sang Hui
authors.initials: SH
authors.lastname: Chu
authors.forename: Kyong-Mee
authors.initials: KM
authors.lastname: Chung
authors.forename: Hyun Chul
authors.initials: HC
authors.lastname: Lee
authors.forename: Eui Geum
authors.initials: EG
authors.lastname: Oh
authors.forename: Sang Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Justin Y
authors.initials: JY
authors.lastname: Jeon
mesh_terms: D000293:Adolescent; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D009765:Obesity / Q000097:blood*; D015843:Serpins / Q000097:blood*; D013997:Time Factors
chemical_list: C507339:SERPINA12 protein, human; D015843:Serpins