title: Stolonoxides E and F, cytotoxic metabolites from the marine ascidian Stolonica socialis.
abstract: Two new members of the stolonoxide family, stolonoxides E (1) and F (2), were isolated from samples of the marine ascidian Stolonica socialis collected in Cádiz (Spain). Their structures were determined by a combination of techniques, including (+)-HRESIMS, 1D and 2D NMR spectroscopy, and comparison with published data for the structurally related stolonoxides A-D (3-6). Both compounds displayed cytotoxicity against a panel of three human tumor cell lines.
authors.affiliation: Medicinal Chemistry Department, PharmaMar S.A.U., Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770-Colmenar Viejo, Madrid, Spain. jfreyes@pharmamar.com
authors.forename: Fernando
authors.initials: F
authors.lastname: Reyes
authors.forename: Raquel
authors.initials: R
authors.lastname: Rodríguez-Acebes
authors.forename: Rogelio
authors.initials: R
authors.lastname: Fernández
authors.forename: Santiago
authors.initials: S
authors.lastname: Bueno
authors.forename: Andrés
authors.initials: A
authors.lastname: Francesch
authors.forename: Carmen
authors.initials: C
authors.lastname: Cuevas
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004148:Dioxolanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004148:Dioxolanes; D005663:Furans; C546849:stolonoxide E