[Melioidosis: an emerging tropical disease].
Melioidosis is an infection affecting both human and animal health. The causative agent is Burkholderia pseudomallei, a Gram-negative soil bacterium. Melioidosis is endemic in tropical areas of Southeast Asia and Northern Australia, and sporadic in many other countries. Clinical presentation is variable ranging from acute septicemia, isolated pulmonary infection, or chronic granulomatous lesions to asymptomatic forms with positive serology. There is no vaccine and treatment is difficult because B. pseudomallei is resistant to a wide range of antibiotics. Relapses are common. B. pseudomallei is listed as a biological risk class 3 and considered as a potential bioterrorism agent due to its high virulence by inhalation, to the difficulty of treatment, and to the lack of vaccine.
Valade
E
E
Unité de Bacteriologie/UMR-MD1, Institut de Recherche Biomédicale des Armées/CRSSA, La Tronche. evalade@crssa.net
Thibault
F M
FM
Biot
F V
FV
Vidal
D R
DR
D021821:Communicable Diseases, Emerging; D004197:Disease Reservoirs; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008554:Melioidosis / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy / Q000635:transmission; D012307:Risk Factors; D014329:Tropical Climate