[Identification of susceptibility genes for age-related macular degeneration--a success story of molecular genetics].
The number of persons over 70 years of age with advanced age-related macular degeneration in Finland can be estimated to be approximately 50,000. Milder forms are additionally present in a considerably larger group. Smoking and age are undisputed non-genetic risk factors of age-related macular degeneration. Of the genetic factors, polymorphisms of the complement factor H (CFH) and LOC387715 genes have a strong impact on the risk of developing the disease, whereas alleles of the C3, CFB, and the C1 inhibitor SERPING1 genes of the complement system exhibit only minor effects.
Seitsonen
Sanna
S
HUS:n silmäsairaala, Haartmaninkatu 2, 00290 Helsinki, ja Helsingin yliopisto, Biomedicum, lääketieteellisen, genetiikan osasto.
Onkamo
Päivi
P
Immonen
Ilkka
I
Järvelä
Irma
I
D003174:Complement C1 Inactivator Proteins / Q000235:genetics; D050718:Complement C1 Inhibitor Protein; D017242:Complement Factor H / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
D003174:Complement C1 Inactivator Proteins; D050718:Complement C1 Inhibitor Protein; C469952:SERPING1 protein, human; D017242:Complement Factor H