Successful management of invasive aspergillosis presenting as pericarditis in an adult patient with chronic granulomatous disease.
Invasive aspergillosis (IA) is a major cause of death among patients with chronic granulomatous disease (CGD). Few cases of cardiac aspergillosis have been published on CGD patients. Diagnosis of IA in CGD patients can be hampered by lack of characteristic symptoms and clinical signs and the serum galactomannan assay is often negative. We report the first CGD patient with IA presenting as pericarditis where combined antifungal therapy resulted in a successful outcome.
Mortensen
Klaus L
KL
Knudsen
Jane B
JB
Jensen-Fangel
Søren
S
Stausbøl-Grøn
Brian
B
Arendrup
Maiken C
MC
Petersen
Eskild
E
D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage; D001230:Aspergillus / Q000302:isolation & purification; D004359:Drug Therapy, Combination / Q000379:methods; D004452:Echocardiography; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000473:pathology*; D006801:Humans; D055744:Invasive Pulmonary Aspergillosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D010493:Pericarditis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D013902:Radiography, Thoracic; D016896:Treatment Outcome
D000935:Antifungal Agents