New conjugated benzothiazole-N-oxides: synthesis and biological activity.
Eleven new 2-styrylbenzothiazole-N-oxides have been prepared by aldol - type condensation reactions between 2-methylbenzothiazole-N-oxide and para-substituted benzaldehydes. Compounds with cyclic amino substituents showed typical push-pull molecule properties. Four compounds were tested against various bacterial strains as well as the protozoan Euglena gracilis as model microorganisms. Unlike previously prepared analogous benzothiazolium salts, only weak activity was recorded.
Gajdos
Peter
P
Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, Mlynskádolina CH-2, 842 15 Bratislava, Slovakia.
Magdolen
Peter
P
Zahradník
Pavol
P
Foltínová
Pavlína
P
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D021281:Quantitative Structure-Activity Relationship; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D000981:Antiprotozoal Agents; D052160:Benzothiazoles