[Effects of melatonin on nociception processes in experimentally model of neurophatic pain].
Melatonin (MT) plays an important role in the regulation of physiological and neuroendocrine functions, such as control of circadian rhythms and synchronization of seasonal reproductive rhythms in mammals. Melatonin shows its antinocieeptive effects in a dose - dependent manner. Melatonin is influencing the mechanical allodynia but not thermal hyperalogia. Antinociceptive effects of melatonin are having the significant connection with the MT2 receptor stimulation and activation of the opioid system.
Zurowski
Daniel
D
Katedra Patofizjologii, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków, Poland. danski@mp.pl
Nowak
Łukasz
Ł
Ciesielczyk
Katarzyna
K
Machowska
Anna
A
Thor
Piotr J
PJ
D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D008550:Melatonin / Q000008:administration & dosage* / Q000378:metabolism*; D009619:Nociceptors / Q000187:drug effects*; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D044123:Receptor, Melatonin, MT2 / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism; D012584:Sciatic Nerve / Q000293:injuries; D020426:Sciatic Neuropathy / Q000188:drug therapy*
D044123:Receptor, Melatonin, MT2; D011957:Receptors, Opioid; D008550:Melatonin