[A novel target for the regulation of cardiac arrhythmias--microRNAs].
microRNAs are one kind of endogenous no-encoding RNA with about 22 nucleotides in length, and inhibited the translation of mRNAs by partially complementary binding to the 3' UTR of target mRNAs in the post-transcriptional level. Recent research shows that miRNAs function in the physiological and pathological processes of heart, especially involved in the occurrence and progress of arrhythmias. Abnormal miRNAs alters the protein expression of ion channels, causes the cardiac dysfunction, and triggers heart arrhythmias. The article summarized recent advances about roles of miRNA in arrhythmias and related cardiomyopathy, and discussed the therapeutic potential of miRNAs for heart diseases.
Cai
Ben-Zhi
BZ
Department of Pharmacology, State-province Key Laboratories of Biomedicine Pharmaceutics of China, Cardiovascular Drug Institute, Harbin Medical University, Harbin 150081, China.
Lü
Yan-Jie
YJ
Yang
Bao-Feng
BF
D001145:Arrhythmias, Cardiac / Q000235:genetics / Q000378:metabolism; D009202:Cardiomyopathies / Q000235:genetics / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism
D035683:MicroRNAs