A phosphine-mediated construction of 1,4-oxazepines and 1,3-oxazines.
A simple and efficient method for constructing 1,4-oxazepines and 1,3-oxazines was developed with use of a phosphine-mediated tandem reaction of ynones with 2-azido alcohols. The method offers a promising route to synthetically useful as well as biologically active heterocycles under mild conditions and may be exploited for the preparation of interesting chiral ligands.
François-Endelmond
Céline
C
CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, Gif sur Yvette, F-91191, France.
Carlin
Thomas
T
Thuery
Pierre
P
Loreau
Olivier
O
Taran
Frédéric
F
D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010077:Oxazepines / Q000138:chemical synthesis* / Q000737:chemistry; D010078:Oxazines / Q000138:chemical synthesis* / Q000737:chemistry; D010720:Phosphines / Q000737:chemistry*
D010077:Oxazepines; D010078:Oxazines; D010720:Phosphines; C044646:phosphine