title: Studying NK cell/dendritic cell interactions.
abstract: Although NK cells were originally identified as "naturally" active cells believed to follow a cell-autonomous activation program, it is now widely accepted that NK cells need to interact with dendritic cells for their full functional activation and for their homeostasis. In this chapter, we will provide an experimental guide to the analysis of NK cell/DC interactions in vitro and in vivo. We have put special emphasis on the recently developed mouse models allowing the inducible and specific ablation of various subsets of DCs and other myeloid cells.
authors.affiliation: Institute of Medical Microbiology & Hygiene, University of Freiburg Medical Center, Freiburg, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Lucas
authors.forename: Cedric
authors.initials: C
authors.lastname: Vonarbourg
authors.forename: Peter
authors.initials: P
authors.lastname: Aichele
authors.forename: Andreas
authors.initials: A
authors.lastname: Diefenbach
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology; D002450:Cell Communication; D002460:Cell Line; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000166:cytology* / Q000378:metabolism; D005818:Genetic Engineering; D066257:Heparin-binding EGF-like Growth Factor; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D042541:Intracellular Space / Q000378:metabolism; D007694:Killer Cells, Natural / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D008264:Macrophages / Q000166:cytology; D051379:Mice; D008954:Models, Biological; D022423:Myeloid Cells / Q000378:metabolism; D013194:Staining and Labeling; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D015415:Biomarkers; D016207:Cytokines; C587883:HBEGF protein, human; C587884:Hbegf protein, mouse; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D051193:Toll-Like Receptors