[Synthesis and biological evaluation of 3-quinolinecarbonitrile-7-amide derivatives].
A series of N-(3-cyano-6-methyl-4-anilinoquinoline-7-yl) amide derivatives 13a-13n have been synthesized, their structures were confirmed with 1H NMR, EI-MS, IR and elemental analysis. Antitumor activities of all the synthesized compounds in vitro were tested with MTT. Compound 13j showed better than or equal antitumor activity on Bosutinib and EKB-569.
Liu
Bao
B
Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
You
Qi-Dong
QD
Li
Zhi-Yu
ZY
D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000814:Aniline Compounds; D000970:Antineoplastic Agents; D011804:Quinolines