title: Comparison of two fixed activities of radioiodine therapy (370 vs. 555 MBq) in patients with Graves' disease.
abstract: OBJECTIVE
  Radioiodine therapy is the most commonly used therapy for patients with Graves' disease (GD) in the United Kingdom. It is considered safe, effective and relatively inexpensive. The aim of our study was to examine the outcome of 131Iodine therapy in patients with GD when two different activities of 131Iodine were used.
  
  
  METHODS
  A retrospective audit was undertaken to compare the efficacy of 370 (10 millicuries) versus 555MBq (15 millicuries) radioiodine therapy in patients with Graves' disease over a period of ten years.
  
  
  RESULTS
  Overall, 90% of the patients had a successful outcome from treatment with no significant difference in the success rate between the lower and higher activities or between genders.
  
  
  CONCLUSIONS
  555 MBq of radioiodine was no more effective than 370 MBq in managing patients with Graves' disease. We therefore recommend that the higher activity should not be routinely used in these patients.
authors.affiliation: The Ayr Hospital, Dalmellington Road, Ayr, Scotland.
authors.forename: Andrew
authors.initials: A
authors.lastname: Collier
authors.forename: Sujoy
authors.initials: S
authors.lastname: Ghosh
authors.forename: Mario
authors.initials: M
authors.lastname: Hair
authors.forename: Iqbal
authors.initials: I
authors.lastname: Malik
authors.forename: Jim
authors.initials: J
authors.lastname: McGarvie
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D054869:Clinical Audit; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006111:Graves Disease / Q000532:radiotherapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D012727:Sex Characteristics; D016896:Treatment Outcome; D006113:United Kingdom
chemical_list: D007457:Iodine Radioisotopes