title: [A case of the local advanced gastric cancer which became a resection possible in S-1/CDDP/lentinan neoadjuvant chemotherapy].
abstract: A 61-year-old man with esophagus invasive advanced gastric cancer and peritoneum dissemination underwent three courses of S-1/CDDP/Lentinan (LNT) combination neoadjuvant chemotherapies (T3N1P1H0, Stage IV) (It is S-1 80 mg/m2,CDDP 15 mg/m2 and LNT 2 mg/body twice/week for two weeks) since down staging was obtained. We performed the surgery of total gastrectomy, splenectomy, D2 lymph node dissection, and Roux-en Y reconstruction in March 2008. With the surgical examination, there was no ascites and peritoneal dissemination. Although there was serious infiltration, we were able to remove it. In the histopathological effect judgment, it was Grade 1b. We changed the therapy to S-1 alone after the same chemotherapy for six months. One year after the operation, he is still alive one year after the surgery.
authors.affiliation: Department of Surgery, Kashiwara Municipal Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hori
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Ikehara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takatsuka
authors.forename: Tatsunari
authors.initials: T
authors.lastname: Fukuoka
authors.forename: Masanari
authors.initials: M
authors.lastname: Tendou
authors.forename: Kenji
authors.initials: K
authors.lastname: Tezuka
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Dan
authors.forename: Hiroji
authors.initials: H
authors.lastname: Nishino
authors.forename: Kosei
authors.initials: K
authors.lastname: Hirakawa
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D005743:Gastrectomy; D006801:Humans; D007912:Lentinan / Q000008:administration & dosage; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010094:Oxonic Acid / Q000008:administration & dosage; D013156:Splenectomy; D013274:Stomach Neoplasms / Q000628:therapy*; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D007912:Lentinan; D010094:Oxonic Acid; D002945:Cisplatin