title: [Evaluation of preoperative chemoradiation therapy for lower rectal carcinoma using DWIBS].
abstract: We investigated the efficacy of diffusion-weighed whole body imaging with background body signal suppression (DWIBS) in assessing effects of chemoradiation therapy (CRT) on rectal carcinoma. DWIBS was performed in patients (n=12) with primary rectal carcinoma undergoing preoperative CRT before and 3 weeks after the treatment. Each patient received a total irradiation dose of 45 Gy at a single dose of 1.8 Gy administered once daily. Parallel to this, in the 1st, 3rd and 5th weeks 350 mg/m2 5-fluorouracil and 35 mg/m2 l-leucovorin were administered for 5 days. The apparent diffusion coefficient (ADC) was measured by DWIBS and surgical resection of the tumors enabled a correlation of ADC values with the pathological findings. With respect to histopathological grading of regression, two, five and five cases exhibited Grade 3, Grade 2 and Grade 1, respectively. In all patients, ADC values were higher after completion of CRT compared to those before it( 1.23+/-0.26x10(-3) mm2/s vs 0.75+/-0.13x10(-3) mm2/s, p<0.001). After completion of CRT, mean ADC values were 1.71+/-0.38x10(-3) mm2/s, 1.25+/-0.10x10(-3) mm2/s and 1.02+/-0.08x10(-3) mm2/s for Grade 3, Grade 2 and Grade 1, respectively. These preliminary results indicate that DWIBS may be a valuable tool to assess effects of CRT on rectal carcinoma by using appropriate cut-off values.
authors.affiliation: Department of Frontier Surgery, Chiba University Graduate School of Medicine.
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Saito
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Shuto
authors.forename: Gaku
authors.initials: G
authors.lastname: Ohira
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Natsume
authors.forename: Kazuo
authors.initials: K
authors.lastname: Narushima
authors.forename: Asami
authors.initials: A
authors.lastname: Sato
authors.forename: Takumi
authors.initials: T
authors.lastname: Ota
authors.forename: Haruto
authors.initials: H
authors.lastname: Sakata
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Miyauchi
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Matsubara
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D012004:Rectal Neoplasms / Q000175:diagnosis* / Q000628:therapy*