Two cases of corneal perforation after oral administration of nonsteroidal anti-inflammatory drugs: oral NSAID-induced corneal damage.
OBJECTIVE
To report 2 cases of corneal perforation associated with the use of oral nonsteroidal anti-inflammatory drugs (NSAIDs).


METHODS
In a 62-year-old woman and a 79-year-old woman, corneal perforation occurred after 7 days and 5 months of oral NSAIDs administration, respectively.


RESULTS
After NSAIDs were discontinued, the cornea epithelialized and the anterior chamber formed within 14 and 10 days, respectively.


CONCLUSIONS
It is well known that topical NSAIDs cause corneal perforation. Observations in the present cases suggest that the oral administration of NSAIDs may also cause corneal damage, and hence, medical professionals should consider the risk of damage to the cornea when administering these drugs orally.
Masuda
Ikuya
I
Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. masuda-i@cc.okayama-u.ac.jp
Matsuo
Toshihiko
T
Okamoto
Kazuo
K
Matsushita
Kyoko
K
Ohtsuki
Hiroshi
H
D000284:Administration, Oral; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D003315:Cornea / Q000187:drug effects / Q000473:pathology*; D057112:Corneal Perforation / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000188:drug therapy; D014945:Wound Healing
D000894:Anti-Inflammatory Agents, Non-Steroidal