title: Long-term TENS treatment improves tactile sensitivity in MS patients.
abstract: BACKGROUND
  Transcutaneous electrical nerve stimulation (TENS) is commonly used in neurorehabilitation for the treatment of pain and spasticity.
  
  
  OBJECTIVE
  The long-term effects of sensory stimulation by means of TENS on hand sensitivity were investigated in patients with multiple sclerosis (MS).
  
  
  METHODS
  TENS was applied for 3 weeks (1 hour per day) on the median nerve region of the dominant hand. Sensitivity was assessed by the Semmes-Weinstein monofilaments before and 12 hours following the last intervention as well as 3 weeks later.
  
  
  RESULTS
  Long-lasting increases in tactile sensitivity were achieved by repetitive stimulation of sensory afferents with TENS in MS patients but not in healthy subjects. This increased sensitivity was not only restricted to the median nerve area but also expanded to the ulnar nerve area. Remarkably, MS patients reached the same level of sensitivity as healthy subjects immediately after the intervention, and long-term effects were reported 3 weeks later.
  
  
  CONCLUSIONS
  The findings of this study demonstrated lasting improvements in tactile sensitivity of the fingers as a result of a long-term TENS intervention in MS patients, who ultimately reached a level comparable with that of healthy subjects.
authors.affiliation: Hasselt University, Diepenbeek, Belgium. koen.cuypers@phl.be
authors.forename: Koen
authors.initials: K
authors.lastname: Cuypers
authors.forename: Oron
authors.initials: O
authors.lastname: Levin
authors.forename: Herbert
authors.initials: H
authors.lastname: Thijs
authors.forename: Stephan P
authors.initials: SP
authors.lastname: Swinnen
authors.forename: Raf L J
authors.initials: RL
authors.lastname: Meesen
mesh_terms: D000328:Adult; D000368:Aged; D004185:Disability Evaluation; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000503:physiopathology* / Q000534:rehabilitation*; D011597:Psychomotor Performance; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D014110:Touch / Q000502:physiology*; D004561:Transcutaneous Electric Nerve Stimulation; D016896:Treatment Outcome; D055815:Young Adult