title: Preliminary report: circulating levels of the adipokine vaspin in gestational diabetes mellitus and preeclampsia.
abstract: The objective of the study was to investigate serum levels of the insulin-sensitizing adipokine vaspin in patients with gestational diabetes mellitus (GDM) and preeclampsia (PE) as compared with healthy controls of similar gestational age. Vaspin serum levels were quantified by enzyme-linked immunosorbent assay in control (n = 102), GDM (n = 40), and PE (n = 22) subjects. Median maternal vaspin concentrations were not significantly different in GDM, PE, and control subjects. Furthermore, vaspin did not significantly correlate to clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation. Circulating vaspin levels are not significantly different between GDM, PE, and control subjects and do not correlate with insulin sensitivity in pregnant subjects.
authors.affiliation: Department of Obstetrics, University of Leipzig, Leipzig, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Stepan
authors.forename: Susan
authors.initials: S
authors.lastname: Kralisch
authors.forename: Katrin
authors.initials: K
authors.lastname: Klostermann
authors.forename: Susanne
authors.initials: S
authors.lastname: Schrey
authors.forename: Constanze
authors.initials: C
authors.lastname: Reisenbüchler
authors.forename: Michael
authors.initials: M
authors.lastname: Verlohren
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Verlohren
authors.forename: Kathrin
authors.initials: K
authors.lastname: Drynda
authors.forename: Matthias
authors.initials: M
authors.lastname: Blüher
authors.forename: Michael
authors.initials: M
authors.lastname: Stumvoll
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kratzsch
authors.forename: Peter
authors.initials: P
authors.lastname: Kovacs
authors.forename: Mathias
authors.initials: M
authors.lastname: Fasshauer
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D016640:Diabetes, Gestational / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D007677:Kidney Function Tests; D050356:Lipid Metabolism / Q000502:physiology; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D015843:Serpins / Q000097:blood*
chemical_list: D001786:Blood Glucose; C507339:SERPINA12 protein, human; D015843:Serpins