Transforming growth factor-beta 1 gene polymorphisms in Korean patients with pre-eclampsia.
OBJECTIVE
The aim of this study was to investigate whether c.869T>C (Leu10Pro) and c.915G>C (Arg25Pro) polymorphisms in exon1 of the transforming growth factor-beta1 (TGF-beta1) gene are associated with development of pre-eclampsia (PE) in Korean women.


METHODS
We analyzed blood samples from 164 patients with PE and 182 healthy pregnant women using the polymerase chain reaction and DNA sequencing.


RESULTS
The frequencies of the 869CC and combined TC/CC genotypes were higher in patients with PE than in healthy controls. In the PE with intrauterine growth restriction (IUGR), the frequencies of these genotypes were also higher than that in controls. Furthermore, the 869C allele frequency was significantly higher in both PE and IUGR-complicated PE than in controls. Multivariate analysis showed that the 869TC, CC, and combined TC/CC genotypes were associated with an increased risk of PE compared with the 869TT genotype. In addition, the 869TC, CC, and combined TC/CC genotypes were significantly associated with an increased risk of IUGR-complicated PE compared with the 869TT genotype. The TGF-beta1 c.915G>C polymorphism was not detected in our population.


CONCLUSIONS
Our findings indicate that the TGF-beta1 c.869T>C polymorphism may be a genetic risk factor for PE and IUGR-complicated PE.
Kim
Shin Young
SY
Laboratory of Medical Genetics, Cheil General Hospital and Women's Healthcare Center, Seoul, Korea.
Lim
Ji Hyae
JH
Park
So Yeon
SY
Yang
Jae Hyug
JH
Kim
Moon Young
MY
Kim
Min Hyoung
MH
Ryu
Hyun Mee
HM
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
D053773:Transforming Growth Factor beta1