title: Synthesis, in vitro and in vivo studies of Gd-DTPA-XDA-D1-Glc(OH) complex as a new potential MRI contrast agent.
abstract: A new type of dendritic molecules Gd-DTPA-XDA-D1-Glc(OH), which work as a functionalized ligand coordinating gadolinium(III) ion at the center of their frameworks with two glucose moieties on the molecular surfaces, were readily synthesized with high yield. The structures were established by IR, (1)H, (13)C NMR, and mass spectral studies. Its bio-distribution patterns were evaluated on rats.
authors.affiliation: Graduate School of Science and Technology, Shizuoka University, Hamamatsu 432-8561, Japan.
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Ozaki
authors.forename: Arigala Uma Ravi
authors.initials: AU
authors.lastname: Sankar
authors.forename: Mitsuji
authors.initials: M
authors.lastname: Yamashita
authors.forename: Takashi
authors.initials: T
authors.lastname: Aoki
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Motohiko
authors.initials: M
authors.lastname: Kimura
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Toda
authors.forename: Michio
authors.initials: M
authors.lastname: Fujie
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Takehara
authors.forename: Harumi
authors.initials: H
authors.lastname: Sakahara
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis*; D019786:Gadolinium DTPA / Q000032:analysis / Q000138:chemical synthesis*; D005947:Glucose / Q000032:analysis / Q000138:chemical synthesis*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods; D011877:Radionuclide Imaging; D051381:Rats
chemical_list: D003287:Contrast Media; D005947:Glucose; D019786:Gadolinium DTPA