title: [Calcium antagonists: current and future applications based on new evidence. Calcium channel blockers and single-pill combination].
abstract: Ca channel blocker (CCB) is widely used as an anti-hypertensive and anti-ischemic heart disease drug in Japan. CCB or angiotensin receptor antagonist (ARB) is selected as a first line anti-hypertensive drug. However, mono-therapy is often insufficient and combination therapy is needed to achieve the adequate blood pressure control. Hypertensive patients are also sometimes combined with dyslipidemia. In these reasons, a single pill combination of CCB and ARB or statin play an important role in hypertensive and anti-atherosclerotic therapy.
authors.affiliation: Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Okura
authors.forename: Jitsuo
authors.initials: J
authors.lastname: Higaki
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000008:administration & dosage*; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D004338:Drug Combinations; D050171:Dyslipidemias / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D004338:Drug Combinations; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors