title: Rapid development of an efficacious swine vaccine for novel H1N1.
abstract: Recombinant hemagglutinin (HA) from a novel H1N1 influenza strain was produced using an alphavirus replicon expression system. The recombinant HA vaccine was produced more rapidly than traditional vaccines, and was evaluated as a swine vaccine candidate at different doses in a challenge model utilizing the homologous influenza A/California/04/2009 (H1N1) strain. Vaccinated animals showed significantly higher specific antibody response, reduced lung lesions and viral shedding, and higher average daily gain when compared to non-vaccinated control animals. These data demonstrate that the swine vaccine candidate was efficacious at all of the evaluated doses.
authors.affiliation: Harrisvaccines, Inc., Ames, IA, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Vander Veen
authors.forename: Kurt
authors.initials: K
authors.lastname: Kamrud
authors.forename: Mark
authors.initials: M
authors.lastname: Mogler
authors.forename: Alan T
authors.initials: AT
authors.lastname: Loynachan
authors.forename: Jerry
authors.initials: J
authors.lastname: McVicker
authors.forename: Peter
authors.initials: P
authors.lastname: Berglund
authors.forename: Gary
authors.initials: G
authors.lastname: Owens
authors.forename: Sarah
authors.initials: S
authors.lastname: Timberlake
authors.forename: Whitney
authors.initials: W
authors.lastname: Lewis
authors.forename: Jonathan
authors.initials: J
authors.lastname: Smith
authors.forename: D L Hank
authors.initials: DL
authors.lastname: Harris