title: [Effects of ShenSongYangXin on action potential and some current channels in isolated rabbit pulmonary vein cardiomyocytes].
abstract: OBJECTIVE
  To investigate the effects of ShenSongYangXin on action potential and some current channels in isolated rabbit pulmonary vein cardiomyocytes and to elucidate its possible mechanism of curing atrial fibrillation.
  
  
  METHODS
  Action potentials as well as L-type calcium channel current (I(Ca-L)), transient outward potassium current (I(K1)) and inward rectifier potassium current (I(To)) were recorded using whole cell patch-clamp technique.
  
  
  RESULTS
  ShenSongYangXin prolonged the action potential duration (APD) significantly, APD90 was enlarged from (187 +/- 49) ms to (286 +/- 76) ms at the concentration of 5 mg/ml and to (312 +/- 82) ms at the concentration of 10 mg/dl respectively (P < 0.05). It also depressed the current of I(Ca-L), I(K1) and Iro in a concentration-dependent manner.
  
  
  CONCLUSIONS
  ShenSongYangXin can be used to treat atrial fibrillation through its actions on multiple current channels.
authors.affiliation: Heart Center, Beijing Chao-Yang Hospital, Capital University of Medical Sciences, Beijing 100020, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Shi
authors.forename: Xin-Chun
authors.initials: XC
authors.lastname: Yang
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Zong
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Wu
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D001281:Atrial Fibrillation; D020746:Calcium Channels, L-Type / Q000378:metabolism*; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008297:Male; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism; D018408:Patch-Clamp Techniques; D024661:Potassium Channels, Inwardly Rectifying / Q000378:metabolism*; D011667:Pulmonary Veins / Q000166:cytology; D011817:Rabbits
chemical_list: D020746:Calcium Channels, L-Type; D004365:Drugs, Chinese Herbal; D024661:Potassium Channels, Inwardly Rectifying; C530959:shensongyangxin