Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida.
Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC(50)) at a concentration of less than 1 microM, and 3 showed gelatinases A and B inhibitory activity (IC(50)) at 0.4 and 2.3 microM, respectively.
Moon
Hyung-In
HI
Inam Neuroscience Research Center, Wonkwang University Sanbon Medical Center, Sanbon-dong, Gunpocity, Kyunggi-Do 435-040, South Korea.
Kim
Tae-im
TI
Cho
Hyun-Soo
HS
Kim
Eung Kweon
EK
D017364:Collagenases / Q000378:metabolism; D027825:Crataegus; D018093:Gelatinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves
D061965:Matrix Metalloproteinase Inhibitors; D010936:Plant Extracts; D017364:Collagenases; D018093:Gelatinases