Acute phase response in animals: a review.
The acute phase response is a complex systemic early-defense system activated by trauma, infection, stress, neoplasia, and inflammation. Although nonspecific, it serves as a core of the innate immune response involving physical and molecular barriers and responses that serve to prevent infection, clear potential pathogens, initiate inflammatory processes, and contribute to resolution and the healing process. Acute phase proteins, an integral part of the acute phase response, have been a focus of many applications in human diagnostic medicine and recently have been identified in common animal species. Potential applications to diagnosis, prognosis, assessment of animal health, and laboratory animal welfare are readily apparent.
Cray
Carolyn
C
Division of Comparative Pathology, University of Miami Miller School of Medicine, Miami, Florida, USA. c.cray@miami.edu
Zaias
Julia
J
Altman
Norman H
NH
D000209:Acute-Phase Proteins / Q000032:analysis; D000210:Acute-Phase Reaction; D000818:Animals; D002097:C-Reactive Protein / Q000032:analysis; D007249:Inflammation / Q000175:diagnosis / Q000378:metabolism; D011379:Prognosis; D000685:Serum Amyloid A Protein / Q000032:analysis
D000209:Acute-Phase Proteins; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein