title: Pd-catalyzed intramolecular acylation of aryl bromides via C-H functionalization: a highly efficient synthesis of benzocyclobutenones.
abstract: A new catalyst system for the intramolecular acylation of aldehydes with aryl bromides via C-H functionalization is described. The transformation is distinguished by a remarkable functional group tolerance and hence allows for the synthesis of a wide variety of highly functionalized benzocyclobutenones with a diverse set of substitution patterns from simple and easily accessible precursors.
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), 43007 Tarragona, Spain.
authors.forename: Paula
authors.initials: P
authors.lastname: Alvarez-Bercedo
authors.forename: Areli
authors.initials: A
authors.lastname: Flores-Gaspar
authors.forename: Arkaitz
authors.initials: A
authors.lastname: Correa
authors.forename: Ruben
authors.initials: R
authors.lastname: Martin
mesh_terms: D000215:Acylation; D002384:Catalysis; D003500:Cyclization; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006842:Hydrocarbons, Brominated; D007659:Ketones; D009942:Organometallic Compounds; D011083:Polycyclic Compounds; C079040:benzocyclobutene; D010165:Palladium