title: Fast transient thermal analysis of gold nanoparticles in tissue-like medium.
abstract: Gold-nanoparticle-based hyperthermia has attracted considerable attention in the recent ten years in cancer treatment. In hyperthermia-based cancer treatment, in order to produce efficient thermal therapy yet without excessive heat damage to human body, besides the steady-state thermal condition, the transient thermal response is of vital importance. As part of theoretical research associated with nanoparticle-mediated hyperthermia therapy for cancer treatment, the transient heat transfer process of laser interacting with gold nanoparticle in tissue-like medium is investigated. Within the framework of dual-phase-lag (DPL) model, this paper focuses on the microscopic heat transfer performance of a gold nanoparticle in a surrounding medium. A semianalytical solution of 1-D nonhomogenous DPL equation in spherical coordinates is presented for a heat transfer process with a constant laser heat source and a short-pulsed laser heating source. Results show that the transient temperature calculated by DPL model greatly exceeds that predicted by the classical diffusion model, with either a constant source or a pulsed source. This phenomenon is mainly attributed by the phase lag of heat flux in the surrounding tissue.
authors.affiliation: Shanghai Jiao Tong University, Shanghai 200030, China. lchsh@umd.umich.edu
authors.forename: Changhong
authors.initials: C
authors.lastname: Liu
authors.forename: Ben Q
authors.initials: BQ
authors.lastname: Li
authors.forename: Chunting Chris
authors.initials: CC
authors.lastname: Mi
mesh_terms: D000818:Animals; D003198:Computer Simulation; D003238:Connective Tissue / Q000528:radiation effects*; D004735:Energy Transfer / Q000528:radiation effects; D006046:Gold / Q000737:chemistry* / Q000528:radiation effects*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007834:Lasers; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry* / Q000528:radiation effects*; D013696:Temperature; D013814:Thermal Conductivity
chemical_list: D006046:Gold