No effect of parental age on risk of multiple sclerosis: a population-based study.
BACKGROUND
Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. A clear parent-of-origin effect has been shown in several populations. Advanced maternal age has been shown to be associated with adverse outcomes in offspring including chromosomal abnormalities. Advanced paternal age is associated with a number of adult onset disorders including schizophrenia and bipolar disorder. In a population-based Canadian cohort, we investigated whether there is any difference in parental age at birth for MS index cases compared to spouse controls.


METHODS
Using the longitudinal Canadian database, we identified 5,681 MS index cases and 1,249 spouse controls with complete information on parental dates of birth, thereby allowing a calculation of the maternal and paternal ages at the birth of their children (MS index cases and spouse controls).


RESULTS
No significant difference in maternal or paternal age at birth was found (average MS index case maternal age at birth = 27.3 years, average spouse control maternal age at birth = 27.0 years, p = 0.13; average MS index case paternal age at birth = 30.7 years, average spouse control paternal age at birth = 30.2 years, p = 0.37).


CONCLUSIONS
Parental age at birth is not associated with susceptibility to MS.
Ramagopalan
Sreeram V
SV
Wellcome Trust Centre for Human Genetics, Oxford, UK.
Dyment
David A
DA
Guimond
Colleen
C
Yee
Irene M
IM
Ebers
George C
GC
Sadovnick
A Dessa
AD
D000328:Adult; D000367:Age Factors; D002170:Canada; D016022:Case-Control Studies; D015331:Cohort Studies; D005220:Fathers; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009035:Mothers; D009103:Multiple Sclerosis / Q000453:epidemiology*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000453:epidemiology; D010290:Parents; D012044:Regression Analysis; D018454:Spouses; D055815:Young Adult