title: Optical biopsy system distinguishing between hyperplastic and adenomatous polyps in the colon during colonoscopy.
abstract: BACKGROUND
  It has been established that the removal of adenomatous colon polyps drastically reduces the incidence of colorectal cancer (CRC), but polypectomy is not without risk. The aim was to determine the correlation between the results of an optical biopsy system and the histopathology report of the physical biopsy specimens of the same polyps removed at colonoscopy.
  
  
  METHODS
  Paired optical and physical biopsies were performed on 55 polyps with complete polypectomy of the same tissue.
  
  
  RESULTS
  Fifty-three adenomatous polyps and two hyperplastic polyps were identified by the hospital pathologist. The optical biopsy system identified 52 polyps as suspect (adenomatous) and 2 as non-suspect (hyperplastic). One villous adenoma could not be optically analyzed due to friability.
  
  
  CONCLUSIONS
  The WavSTAT Optical Biopsy System provides accurate information to the gastroenterologist to assist in distinguishing between hyperplastic and adenomatous polyps. It is safe for the patient and does not unduly increase the time required for an endoscopic examination.
authors.affiliation: Thomayer Teaching Hospital, Videnska 800, 140 00 Prague 4, Czech Republic. beneszdenek@atlas.cz
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Benes
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Antos
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000473:pathology; D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods; D003106:Colon / Q000473:pathology*; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000473:pathology; D003113:Colonoscopy / Q000379:methods; D003937:Diagnosis, Differential; D006801:Humans; D006965:Hyperplasia / Q000175:diagnosis; D008875:Middle Aged; D055095:Optics and Photonics / Q000379:methods; D011446:Prospective Studies