Plasma visfatin levels in pregnant women with normal glucose tolerance, gestational diabetes and pre-gestational diabetes mellitus.
OBJECTIVE
Visfatin, an adipocytokine, is a peptide predominantly expressed in and secreted from visceral adipose. In this study, we aimed to compare visfatin levels in gestational (GDM) and pre-gestational diabetic (pre-GDM) women with healthy pregnant women. We also sought to determine whether there was a correlation between visfatin levels and serum glucose levels at 1 h after the 50-g oral glucose challenge test in pregnant women with GDM and normal glucose tolerance.


METHODS
The study consisted of 65 pregnant women: 21 patients with GDM (Group 1), 20 patients with pre-GDM (Group 2) and 24 gestational age and BMI-matched healthy pregnant women (Group 3) were enrolled.


RESULTS
Plasma visfatin levels in Groups 1 and 2 were significantly higher than in Group 3 (P < 0.001). Plasma visfatin levels in Groups 1 and 2 were similar (P > 0.05). There was no significant correlation between visfatin levels and serum glucose levels at 1 h after the glucose tolerance test in both Groups 1 and 3 (P > 0.05).


CONCLUSIONS
Our results support the literature indicating higher visfatin levels in women with GDM compared to women with normal glucose tolerance. Interestingly, we found similarly high visfatin levels in women with pre-GDM.
Coskun
Ayhan
A
Department of Obstetrics and Gynecology, Kahramanmaras Sutcuimam University, Kahramanmaras, Turkey. acoskun@ksu.edu.tr
Ozkaya
Mesut
M
Kiran
Gurkan
G
Kilinc
Metin
M
Arikan
Deniz Cemgil
DC
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005865:Gestational Age; D018149:Glucose Intolerance / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D011236:Prediabetic State / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood; D055815:Young Adult
D001786:Blood Glucose; D054409:Nicotinamide Phosphoribosyltransferase