Effects of single and combined administration of fermented barley extract and gamma-aminobutyric acid on the development of atopic dermatitis in NC/Nga mice.
We examined the effects single and combined administration of fermented barley extract P (FBEP), prepared from barley-shochu distillery by-products, and gamma-aminobutyric acid (GABA) on the development of atopic dermatitis (AD)-like skin lesions in NC/Nga mice. Single administration of FBEP and GABA dose-dependently reduced the development of AD-like skin lesions in mice. GABA reduced the development of AD-like skin lesions by suppressing serum immunoglobulin E (IgE) and splenocyte interleukin (IL)-4 production, while FBEP reduced skin lesions without affecting the IgE or cytokine production. However, in mice with induced AD-like skin lesions, combined administration of FBEP and GABA decreased serum IgE levels and splenic cell IL-4 production, and increased splenic cell interferon-gamma production. These results suggest that combined administration of FBEP and GABA alleviated AD-like skin lesions in the NC/Nga mice by adjusting the Th1/Th2 balance to a Th1-predominant immune response.
Hokazono
Hideki
H
Research Laboratory, Sanwa Shurui Co., Ltd., Usa, Oita, Japan. hokazono-h@kokuzo.co.jp
Omori
Toshiro
T
Ono
Kazuhisa
K
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D005285:Fermentation; D001467:Hordeum / Q000737:chemistry* / Q000378:metabolism; D007073:Immunoglobulin E / Q000097:blood; D051379:Mice; D010853:Picryl Chloride / Q000008:administration & dosage / Q000494:pharmacology; D010936:Plant Extracts / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage* / Q000494:pharmacology*
D016207:Cytokines; D010936:Plant Extracts; D007073:Immunoglobulin E; D005680:gamma-Aminobutyric Acid; D010853:Picryl Chloride