title: Malondialdehyde-deoxyguanosine adducts among workers of a Thai industrial estate and nearby residents.
abstract: BACKGROUND
  Humans living near industrial point emissions can experience high levels of exposures to air pollutants. Map Ta Phut Industrial Estate in Thailand is the location of the largest steel, oil refinery, and petrochemical factory complexes in Southeast Asia. Air pollution is an important source of oxidative stress and reactive oxygen species, which interact with DNA and lipids, leading to oxidative damage and lipid peroxidation, respectively.
  
  
  OBJECTIVE
  We measured the levels of malondialdehyde-deoxyguanosine (dG) adducts, a biomarker of oxidative stress and lipid peroxidation, in petrochemical workers, nearby residents, and subjects living in a control district without proximity to industrial sources.
  
  
  METHODS
  We conducted a cross-sectional study to compare the prevalence of malondialdehyde-dG adducts in groups of subjects experiencing various degrees of air pollution.
  
  
  RESULTS
  The multivariate regression analysis shows that the adduct levels were associated with occupational and environmental exposures to air pollution. The highest adduct level was observed in the steel factory workers. In addition, the formation of DNA damage tended to be associated with tobacco smoking, but without reaching statistical significance. A nonsignificant increase in DNA adducts was observed after 4-6 years of employment among the petrochemical complexes.
  
  
  CONCLUSIONS
  Air pollution emitted from the Map Ta Phut Industrial Estate complexes was associated with increased adduct levels in petrochemical workers and nearby residents. Considering the mutagenic potential of DNA lesions in the carcinogenic process, we recommend measures aimed at reducing the levels of air pollution.
authors.affiliation: Cancer Risk Factor Branch, Analytical and Biomolecular Cytology Unit, ISPO-Cancer Prevention and Research Institute, Florence, Italy. m.peluso@ispo.toscana.it
authors.forename: Marco
authors.initials: M
authors.lastname: Peluso
authors.forename: Petcharin
authors.initials: P
authors.lastname: Srivatanakul
authors.forename: Armelle
authors.initials: A
authors.lastname: Munnia
authors.forename: Adisorn
authors.initials: A
authors.lastname: Jedpiyawongse
authors.forename: Marcello
authors.initials: M
authors.lastname: Ceppi
authors.forename: Suleeporn
authors.initials: S
authors.lastname: Sangrajrang
authors.forename: Sara
authors.initials: S
authors.lastname: Piro
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000633:toxicity; D000397:Air Pollution / Q000517:prevention & control; D003430:Cross-Sectional Studies; D018736:DNA Adducts / Q000097:blood*; D004781:Environmental Exposure / Q000517:prevention & control; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D007221:Industry; D007962:Leukocytes / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009153:Mutagens / Q000633:toxicity; D016273:Occupational Exposure / Q000517:prevention & control; D011684:Purine Nucleosides / Q000097:blood*; D013785:Thailand
chemical_list: C491625:3-(2'-deoxy-beta-D-erythro-pentofuranosyl)pyrimido(1,2-alpha)purin-10(3H)-one; D000395:Air Pollutants, Occupational; D018736:DNA Adducts; D009153:Mutagens; D011684:Purine Nucleosides