title: A divergent strategy for attaching polypyridyl ligands to peptides.
abstract: A divergent method for incorporating polypyridyl ligands into peptides is reported. Three N-Fmoc unnatural amino acids (1-3) that contain varying linkers between the alpha-carbon and a 2-(hydroxymethyl)pyridyl group were synthesized in enantioenriched form. These amino acids were used as anchors for incorporating multidentate ligands onto a peptide chain in a site-specific fashion. Multiple peptide-ligand conjugates were synthesized from single precursors by solution- or solid-phase methods. Peptides containing more than one metal-binding unit can be produced by this method.
authors.affiliation: Department of Chemistry, Wayne State Universty, 5101 Cass Ave, Detroit, Michigan 48202, USA.
authors.forename: Nitinkumar D
authors.initials: ND
authors.lastname: Jabre
authors.forename: Tomasz
authors.initials: T
authors.lastname: Respondek
authors.forename: Selma A
authors.initials: SA
authors.lastname: Ulku
authors.forename: Nadiya
authors.initials: N
authors.lastname: Korostelova
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Kodanko
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D017510:Protein Folding; D011725:Pyridines / Q000737:chemistry*; D012996:Solutions
chemical_list: D000596:Amino Acids; D008024:Ligands; D008670:Metals; D009942:Organometallic Compounds; D010455:Peptides; D011725:Pyridines; D012996:Solutions