title: Hyperhemolysis in a patient with beta-thalassemia major.
abstract: A case of hyperhemolysis in a 2-year-old boy with beta thalassemia major was noted. After several transfusions, he developed hyperhemolysis with a positive (C3d only) direct antiglobulin test (DAT) and no clinically significant RBC allo- or auto-antibodies. (There was a weak cold antibody, showing a narrow thermal range). Because there was no significant improvement with steroid and immunoglobulin infusions, cyclophosphamide therapy was tried with notable success.
authors.forename: Lakmali R
authors.initials: LR
authors.lastname: Morawakage
authors.forename: B J C
authors.initials: BJ
authors.lastname: Perera
authors.forename: P D N
authors.initials: PD
authors.lastname: Dias
authors.forename: S K
authors.initials: SK
authors.lastname: Wijewardana