Computerized cognition assessment during acetylcholinesterase inhibitor treatment in Alzheimer's disease.
OBJECTIVE
Alzheimer's disease assessment scale-cognitive subscale (ADAS-Cog) has become a standard clinical trials outcome for cognition, but has been recognized as deficient in areas including coverage of cognitive domains, sensitivity and standardization. Computerized test batteries may address some of these issues. The cognitive drug research computerized assessment (CDR) system is validated in Alzheimer's disease (AD). This study was designed to further evaluate validity in relation to ADAS-Cog, mini mental state examination (MMSE) and cerebrospinal fluid (CSF) biomarkers and psychometric properties, in a population of Alzheimer's patients on stable anticholinesterase treatment.


METHODS
Patients completed cognition assessments, CSF and blood sampling at baseline and 6 months later. Data for 65 patients were evaluated.


RESULTS
The CDR system demonstrated good psychometric properties in this population. Measures of psychomotor speed showed possible sensitivity to decline over 6 months.


CONCLUSIONS
There are a number of methodological problems with current cognition assessment methodology for clinical trials. Computerized measures and in particular millisecond reaction time measures, may address many of these issues.
Wesnes
K
K
United BioSource Corporation, Goring-on-Thames, UK.
Edgar
C
C
Andreasen
N
N
Annas
P
P
Basun
H
H
Lannfelt
L
L
Zetterberg
H
H
Blennow
K
K
Minthon
L
L
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000523:psychology*; D001288:Attention; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D003071:Cognition; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D011594:Psychometrics; D011597:Psychomotor Performance; D015203:Reproducibility of Results
D002800:Cholinesterase Inhibitors