title: Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length.
abstract: Bicyclic tetrapeptide hydroxamic acids were prepared as histone deacetylase (HDAC) inhibitors, and the evaluated inhibitory activity shows that they are potent against HDAC1 and HDAC4. The in vivo activity depends on alkyl loop length.
authors.affiliation: Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, Japan.
authors.forename: Nurul M
authors.initials: NM
authors.lastname: Islam
authors.forename: Tamaki
authors.initials: T
authors.lastname: Kato
authors.forename: Norikazu
authors.initials: N
authors.lastname: Nishino
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ito
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshida
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D056572:Histone Deacetylase Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D006655:Histone Deacetylases / Q000737:chemistry / Q000378:metabolism*; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D001643:Bridged Bicyclo Compounds; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D009842:Oligopeptides; D006655:Histone Deacetylases