title: Role of endogenous testosterone concentration in pediatric stroke.
abstract: Previous studies have indicated a male predominance in pediatric stroke. To elucidate this gender disparity, total testosterone concentration was measured in children with arterial ischemic stroke (AIS; n = 72), children with cerebral sinovenous thrombosis (CSVT; n = 52), and 109 healthy controls. Testosterone levels above the 90th percentile for age and gender were documented in 10 children with AIS (13.9%) and 10 with CSVT (19.2%), totaling 16.7% of patients with cerebral thromboembolism overall, as compared with only 2 of 109 controls (1.8%; p = 0.002). In multivariate analysis with adjustment for total cholesterol level, hematocrit, and pubertal status, elevated testosterone was independently associated with increased disease risk (odds ratio [95% confidence interval]: overall = 3.98 [1.38-11.45]; AIS = 3.88 [1.13-13.35]; CSVT = 5.50 [1.65-18.32]). Further adjusted analyses revealed that, for each 1nmol/l increase in testosterone in boys, the odds of cerebral thromboembolism were increased 1.3-fold.
authors.affiliation: Department of Pediatric Hematology, University Children's Hospital, University of Münster, Münster, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Normann
authors.forename: Gabrielle
authors.initials: G
authors.lastname: de Veber
authors.forename: Manfred
authors.initials: M
authors.lastname: Fobker
authors.forename: Claus
authors.initials: C
authors.lastname: Langer
authors.forename: Gili
authors.initials: G
authors.lastname: Kenet
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Bernard
authors.forename: Barbara
authors.initials: B
authors.lastname: Fiedler
authors.forename: Ronald
authors.initials: R
authors.lastname: Sträter
authors.forename: Neil A
authors.initials: NA
authors.lastname: Goldenberg
authors.forename: Ulrike
authors.initials: U
authors.lastname: Nowak-Göttl
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006400:Hematocrit / Q000379:methods; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D010372:Pediatrics; D012189:Retrospective Studies; D012737:Sex Factors; D012851:Sinus Thrombosis, Intracranial / Q000097:blood*; D020521:Stroke / Q000097:blood*; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone; D002784:Cholesterol