Do atypical antipsychotic drugs reduce the risk of ischemic heart disease and mortality? Possible role of 5-HT2A receptor blockade.
A recent Finnish study reported that long-term cumulative exposure to any antipsychotic treatment was related to lower mortality than was no drug exposure. We hypothesize that the antipsychotic 5-HT2A receptor blockade might protect from ischemic heart disease and buffer the deleterious metabolic effects of antipsychotics. The 5-HT2A receptor may be involved in vascular smooth muscle contraction, coronary artery spasms, platelet aggregation and thrombus formation. 5-HT2A receptor blockade might protect from ischemic heart disease by decreasing platelet aggregation and myocardium hypertrophy. Long-term follow-up studies are needed to clearly establish the long-term contribution of the various antipsychotic drugs to ischemic heart disease, and to explore our hypothesis that 5-HT2A receptor blockade may be protective for cardiovascular disease.
Blasco-Fontecilla
Hilario
H
Fundacion Jimenez Diaz University Hospital, Autonoma University of Madrid, CIBERSAM, Avenida Reyes Catolicos 2, Madrid 28040, Spain.
Baca-Garcia
Enrique
E
de Leon
Jose
J
D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002423:Cause of Death; D006801:Humans; D008134:Long-Term Care; D017202:Myocardial Ischemia / Q000401:mortality* / Q000517:prevention & control*; D011969:Receptors, Histamine H1 / Q000187:drug effects; D012306:Risk; D012559:Schizophrenia / Q000188:drug therapy* / Q000401:mortality*; D058830:Serotonin 5-HT2 Receptor Antagonists; D015430:Weight Gain
D014150:Antipsychotic Agents; D011969:Receptors, Histamine H1; D058830:Serotonin 5-HT2 Receptor Antagonists