Sensitivity of 8 CE (European Community)-approved rapid disposable tests for anti-HIV antibody detection during and after seroconversion.
We evaluated the sensitivity for the anti-HIV antibody detection of the 8 rapid disposable tests (RDTs) EC approved in 2008.


METHODS
A panel of 100 native serum samples collected from HIV-1 subtype B or non-B, HIV-1 group O or HIV-2-infected patient and 3 commercial seroconversion panels were tested. 50 sera from HIV-negative patients were included to blind reading and RDT specificity.


RESULTS
All native samples HIV-1 subtype B were reactive; an HIV-1 non-B subtype gave false-negative results with 3 of the 8 tests. False-negative results on HIV-1 group O samples were observed with one RDT. All the HIV-2 samples were detected. Seroconversion sample reactivity ranged from 60 to 86.7% according to the tests.


CONCLUSIONS
Despite their lower performances relative to ELISA tests during the HIV seroconversion period, RDT may be of interest in case of chronic infection.
Laforgerie
Eric
E
Agence Française de sécurité sanitaire des produits de santé, 93285 Saint-Denis Cedex, France.
Boucher
Béatrice
B
Ly
Thoi Dong
TD
Maisoneuve
Lydia
L
Izopet
Jacques
J
Delaugerre
Constance
C
Simon
François
F
D019411:Clinical Laboratory Techniques / Q000379:methods*; D005062:European Union; D005188:False Negative Reactions; D015483:HIV Antibodies / Q000097:blood*; D015658:HIV Infections / Q000175:diagnosis*; D006679:HIV Seropositivity; D015497:HIV-1 / Q000276:immunology*; D015498:HIV-2 / Q000276:immunology*; D006801:Humans; D007118:Immunoassay / Q000379:methods; D012680:Sensitivity and Specificity
D015483:HIV Antibodies