title: Pycnanthulignenes A-D, antimicrobial cyclolignene derivatives from the roots of Pycnanthus angolensis.
abstract: Investigation of the constituents of Pycnanthus angolensis roots has resulted in the isolation of four new cyclolignene derivatives, named pycnanthulignene A (1), pycnanthulignene B (2), pycnanthulignene C (3), and pycnanthulignene D (4), and six known compounds, 4,5-dimethoxy-3',4'-methylenedioxy-2,7'-cycloligna-7,7'-diene, 2,7-dimethoxy-3,6-dimethylnaphthalene, 4'-methoxy-4,5-methylenedioxy-2,7'-cyclolign-7-ene, genkwainin, 8-hydroxykanzakiflavone-2, and formononetin. The structures of these compounds were established using spectroscopic methods. Compounds 1 and 3 showed significant antimicrobial activities against a panel of drug-resistant pathogens.
authors.affiliation: Department of Organic Chemistry, University of Yaounde I, P.O. Box 812 Yaounde, Cameroon.
authors.forename: Eric C N
authors.initials: EC
authors.lastname: Nono
authors.forename: Pierre
authors.initials: P
authors.lastname: Mkounga
authors.forename: Victor
authors.initials: V
authors.lastname: Kuete
authors.forename: Kirk
authors.initials: K
authors.lastname: Marat
authors.forename: Philip G
authors.initials: PG
authors.lastname: Hultin
authors.forename: Augustin E
authors.initials: AE
authors.lastname: Nkengfack
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002163:Cameroon; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D026324:Myristicaceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D007529:Isoflavones; D017705:Lignans; C548108:pycnanthulignene A; C548109:pycnanthulignene C; C007768:formononetin