[The effect of the "yellow" mutation at the mouse agouti locus on the hormonal profile of pregnancy and lactation].
The "yellow" mutation at the mouse agouti locus (A(y)/a-mice) results in obesity and type 2 diabetes. Maternal obesity in A(y)-mice impaired glucose tolerance in adult Agouti-negative offspring. Changes of hormone pattern during pregnancy and lactation are known to disregulate glucose metabolism in the adult progeny. The aim of the study was to assay blood levels of glucose, insulin, corticosterone and leptin during pregnancy (days 7, 13, 18) and lactation (days 1, 10, 21) in C57B1/6J mice of a/a (normal metabolism) and A(y)/a genotypes. A(y)/a-mice did not differ from a/a-mice in insulin and glucose levels during pregnancy and lactation, in corticosterone levels during pregnancy, but had higher leptin levels in pregnancy and lactation and increased corticosterone levels during lactation. A(y)/a-mice may be considered as a genetic model for studying impact of maternal leptin and corticosterone in developmental programming.
Bazhan
N M
NM
Makarova
E N
EN
D054366:Agouti Signaling Protein / Q000235:genetics*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D003345:Corticosterone / Q000097:blood / Q000378:metabolism; D005260:Female; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007774:Lactation / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D020738:Leptin / Q000097:blood / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008957:Models, Genetic; D009154:Mutation; D009765:Obesity / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000378:metabolism*
D054366:Agouti Signaling Protein; D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; C515183:a protein, mouse; D003345:Corticosterone