Amniocentesis and chorionic villus sampling in twin gestations: which is the best sampling technique?
OBJECTIVE
To compare the fetal loss rate <24 weeks and the preterm premature rupture of the membranes <34 weeks' gestation according to type of invasive procedure and to sampling techniques in twins.


METHODS
Retrospective cohort study of 204 twin pregnancies, who underwent amniocentesis (100) or chorionic villus sampling (104).


RESULTS
Fetal loss rate <4 weeks was 3.85% in chorionic villus sampling group and 4.00% in amniocentesis group (P value not significant). According to sampling technique, fetal loss rate was 4.17% (chorionic villus sampling 1 puncture), 2.70% (amniocentesis 1 puncture), 3.75% (chorionic villus sampling 2 punctures), and 4.76% (amniocentesis 2 punctures), (P values not significant). Preterm premature rupture of the membranes rate <34 weeks was 8.2% chorionic villus sampling group and 10% in amniocentesis group (P value not significant). According to sampling technique, preterm premature rupture of the membranes rate was 12.5% (chorionic villus sampling 1 puncture), 8.1% (amniocentesis 1 puncture), 6.9% (chorionic villus sampling 2 punctures), and 11.1 % (amniocentesis 2 punctures), (P values not significant).


CONCLUSIONS
Double entry technique does not affect significantly the outcomes evaluated, in both amniocentesis and chorionic villus sampling.
Simonazzi
Giuliana
G
Department of Obstetrics and Gynecology, St. Orsola Malpighi Hospital, University of Bologna, Bologna, Italy.
Curti
Alessandra
A
Farina
Antonio
A
Pilu
Gianluigi
G
Bovicelli
Luciano
L
Rizzo
Nicola
N
D000328:Adult; D000649:Amniocentesis / Q000009:adverse effects / Q000706:statistics & numerical data*; D015193:Chorionic Villi Sampling / Q000009:adverse effects / Q000706:statistics & numerical data*; D015331:Cohort Studies; D005260:Female; D005313:Fetal Death / Q000453:epidemiology*; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D012189:Retrospective Studies; D014427:Twins