title: Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice.
abstract: BACKGROUND
  Disruption of the elastic lamina, as an early indicator of aneurysm formation, and vascular calcification frequently occur together in atherosclerotic lesions of humans.
  
  
  RESULTS
  We now report evidence of shared genetic basis for disruption of the elastic lamina (medial disruption) and medial calcification in an F(2) mouse intercross between C57BL/6J and C3H/HeJ on a hyperlipidemic apolipoprotein E (ApoE(-/-)) null
  
  
  BACKGROUND
  gene, known to mediate myocardial calcification. Using transgenic complementation, we show that Abcc6 also contributes to aortic medial calcification.
  
  
  CONCLUSIONS
  Our data indicate that calcification, though possibly contributory, does not always lead to medial disruption and that in addition to aneurysm formation, medial disruption may be the precursor to calcification.
authors.affiliation: Department of Human Genetics, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
authors.forename: Susanna S
authors.initials: SS
authors.lastname: Wang
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Martin
authors.forename: Eric E
authors.initials: EE
authors.lastname: Schadt
authors.forename: Haijin
authors.initials: H
authors.lastname: Meng
authors.forename: Xuping
authors.initials: X
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Leslie
authors.initials: L
authors.lastname: Ingram-Drake
authors.forename: Martina
authors.initials: M
authors.lastname: Nebohacova
authors.forename: Margarete
authors.initials: M
authors.lastname: Mehrabian
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Drake
authors.forename: Aldons J
authors.initials: AJ
authors.lastname: Lusis
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000473:pathology; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism; D050197:Atherosclerosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D002114:Calcinosis; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D040641:Quantitative Trait Loci
chemical_list: D018528:ATP-Binding Cassette Transporters; D001057:Apolipoproteins E; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C504743:Abcc6 protein, mouse