title: [Application of neoadjuvant chemotherapy for operable breast cancer].
abstract: OBJECTIVE
  To investigate the clinical value of neoadjuvant chemotherapy in the treatment of operable breast cancer.
  
  
  METHODS
  A total of 120 patients with pathologically proven operable breast cancer were randomized into two groups to receive 2-4 cycles of neoadjuvant chemotherapy with docetaxel combined with pirarubicin (TThp) or docetaxel combined with epirubicin (TE). Operations were performed two weeks after the neoadjuvant chemotherapy. The short-term therapeutic effect, toxic reaction and the impact of neoadjuvant chemotherapy on the choice of surgical approaches were evaluated.
  
  
  RESULTS
  The total effective rate for the primary sites was 87.2% in these patients, and the rate of breast conservation significantly increased from 12.7% to 41.8% (P<0.05), with a tumor resection rate of 97.2%. The major adverse effects of the therapy included leukopenia, nausea, vomiting and alopecia.
  
  
  CONCLUSIONS
  Neoadjuvant chemotherapy can enhance the breast conservation rate, lower the clinical staging of the tumors and minimize the surgery area to improve the postoperative quality of life of the patients.
authors.affiliation: Department of Breast Surgery, Second People's Hospital of Changzhou, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China. dragon1603@163.com
authors.forename: Lin
authors.initials: L
authors.lastname: Zheng
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Gao
authors.forename: Xiao-lan
authors.initials: XL
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery; D000077143:Docetaxel; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods*; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D015251:Epirubicin; D004317:Doxorubicin; C027260:pirarubicin