Synthesis of nano-sized biphasic calcium phosphate ceramics with spherical shape by flame spray pyrolysis.
Nanometer size biphasic calcium phosphate (BCP) powders with various Ca/P molar ratios satisfied with appropriate phase ratios of HA/beta-TCP were prepared by high temperature flame spray pyrolysis process. The BCP powders had spherical shapes and narrow size distributions irrespective of the ratios of Ca/P. The mean size of the BCP powders measured from the TEM image was 38 nm. The composition ratio of Ca/P was controlled from 1.500 to 1.723 in the spray solution, and required phase ratios of HA/TCP are controlled systematically. The calcium dissolution of the pellets obtained from the BCP powders directly prepared by flame spray pyrolysis in buffer solution increased with the decrease of Ca/P ratios except with the Ca/P ratio of 1.713. The pellet surface with Ca/P ratio of 1.500, which consisted of beta-TCP, was eroded dramatically for 7 days. On the other hand, the pellet surface with Ca/P ratio of 1.667 was stable and did not disintegrate after immersion in Tris-HCl buffer solution based on the SEM observation.
Cho
Jung Sang
JS
Department of Chemical Engineering, Konkuk University, Seoul, Korea.
Ko
You Na
YN
Koo
Hye Young
HY
Kang
Yun Chan
YC
D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry*; D002516:Ceramics / Q000138:chemical synthesis* / Q000737:chemistry; D005410:Flame Ionization / Q000295:instrumentation / Q000379:methods; D006358:Hot Temperature; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry; D009994:Osmolar Concentration; D010316:Particle Size; D011208:Powders; D013499:Surface Properties
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D011208:Powders; C020243:calcium phosphate