title: Antinociceptive effect of the extract of Morus nigra leaves in mice.
abstract: Morus nigra has been used to relieve pain in Brazilian folk medicine. This study was conducted to establish the antinociceptive properties of dichloromethane extract from leaves of M. nigra. The formalin, hot plate, and tail immersion tests as well as acetic acid-induced writhing were used to investigate the antinociceptive activity in mice. The extract at test doses of 100 and 300 mg/kg, p.o. clearly demonstrated antinociceptive activity in all tests. The extract administered at 300 mg/kg, p.o. had a stronger antinociceptive effect than indomethacin (5 mg/kg, p.o.) and morphine (10 mg/kg, p.o.), which supports previous claims for its traditional use.
authors.affiliation: Department of Pharmacy, Federal University of Alfenas-MG, Alfenas, Minas Gerais, Brazil.
authors.forename: Marina
authors.initials: M
authors.lastname: de Mesquita Padilha
authors.forename: Fabiana Cardoso
authors.initials: FC
authors.lastname: Vilela
authors.forename: Marcelo José Dias
authors.initials: MJ
authors.lastname: da Silva
authors.forename: Marcelo Henrique
authors.initials: MH
authors.lastname: dos Santos
authors.forename: Geraldo
authors.initials: G
authors.lastname: Alves-da-Silva
authors.forename: Alexandre
authors.initials: A
authors.lastname: Giusti-Paiva
mesh_terms: D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D031625:Morus / Q000737:chemistry*; D010146:Pain / Q000188:drug therapy*; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000700:Analgesics; D010936:Plant Extracts