[N-terminal pro-brain natriuretic peptide and cardiac involvement in patients with hypertensive disease].
The purpose of this study was to define a correlation between N-terminal proBNP level and extent of cardiac abnormalities. A total of 40 patients with hypertension were included in the study (60.5+/-7.6 years of age; 18 men, 22 women). It was found that patients with hypertension had increased plasma N-terminal proBNP level, that it increased with age and tended to be higher in patients with concentric hypertrophy compared with those with normal geometry and eccentric hypertrophy; however, the differences were not significant. N-terminal proBNP concentration depended on ventricular septal thickness and left ventricular wall thickness. Analysis of association between N-proBNP level and parameters of myocardial diastolic function showed that increased plasma peptide levels correlated with degree of diastolic dysfunction in patients with altered left ventricular relaxation.
Kostoeva
A U
AU
Mazur
N A
NA
Masenko
V P
VP
Sbrodova
L V
LV
Babaev
F Z
FZ
Volkov
V E
VE
Pshenitsin
A I
AI
Khezheva
F M
FM
Shestakova
N V
NV
D000368:Aged; D005260:Female; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology / Q000503:physiopathology; D006334:Heart Function Tests; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D020257:Ventricular Remodeling
D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain