title: Nuclear inositide signaling in myelodysplastic syndromes.
abstract: Myelodysplastic syndromes (MDS) are defined as clonal hematopoietic stem-cell disorders characterized by ineffective hematopoiesis in one or more of the lineages of the bone marrow. Although distinct morphologic subgroups exist, the natural history of MDS is progression to acute myeloid leukemia (AML). However, the molecular the mechanisms the underlying MDS evolution to AML are not completely understood. Inositides are key cellular second messengers with well-established roles in signal transduction pathways, and nuclear metabolism elicited by phosphoinositide-specific phospholipase C (PI-PLC) beta1 and Akt plays an important role in the control of the balance between cell cycle progression and apoptosis in both normal and pathologic conditions. Recent findings evidenced the role played by nuclear lipid signaling pathways, which could become promising therapeutic targets in MDS. This review will provide a concise and updated revision of the state of art on this topic.
authors.affiliation: Cellular Signaling Laboratory, Department of Human Anatomical Sciences, University of Bologna, via Irnerio 48, 40126 Bologna, Italy.
authors.forename: Matilde Y
authors.initials: MY
authors.lastname: Follo
authors.forename: Sara
authors.initials: S
authors.lastname: Mongiorgi
authors.forename: Carlo
authors.initials: C
authors.lastname: Finelli
authors.forename: Cristina
authors.initials: C
authors.lastname: Clissa
authors.forename: Giulia
authors.initials: G
authors.lastname: Ramazzotti
authors.forename: Roberta
authors.initials: R
authors.lastname: Fiume
authors.forename: Irene
authors.initials: I
authors.lastname: Faenza
authors.forename: Lucia
authors.initials: L
authors.lastname: Manzoli
authors.forename: Alberto M
authors.initials: AM
authors.lastname: Martelli
authors.forename: Lucio
authors.initials: L
authors.lastname: Cocco
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000378:metabolism* / Q000503:physiopathology; D010716:Phosphatidylinositols / Q000378:metabolism; D054799:Phospholipase C beta / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D010716:Phosphatidylinositols; D051057:Proto-Oncogene Proteins c-akt; D054799:Phospholipase C beta