title: Hydroxylated sclerosporin derivatives from the marine-derived fungus Cadophora malorum.
abstract: The marine-derived fungus Cadophora malorum was isolated from the green alga Enteromorpha sp. Growth on a biomalt medium supplemented with sea salt yielded an extract, from which we have isolated sclerosporin and four new hydroxylated sclerosporin derivatives, namely, 15-hydroxysclerosporin (2), 12-hydroxysclerosporin (3), 11-hydroxysclerosporin (4), and 8-hydroxysclerosporin (5). The compounds were evaluated in various biological activity assays. Compound 5 showed a weak fat-accumulation inhibitory activity against 3T3-L1 murine adipocytes.
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
authors.forename: Celso
authors.initials: C
authors.lastname: Almeida
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Eguereva
authors.forename: Stefan
authors.initials: S
authors.lastname: Kehraus
authors.forename: Carsten
authors.initials: C
authors.lastname: Siering
authors.forename: Gabriele M
authors.initials: GM
authors.lastname: König
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001410:Bacillus megaterium / Q000187:drug effects; D002708:Chlorella / Q000187:drug effects; D000460:Chlorophyta / Q000382:microbiology; D004926:Escherichia coli / Q000187:drug effects; D055325:Eurotium / Q000187:drug effects; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D012717:Sesquiterpenes