title: Development and application of a solution-phase automated synthesizer, 'ChemKonzert'.
abstract: In this paper we describe the development of a fully-automated solution-phase synthesizer, 'ChemKonzert' that can be used to prepare a wide variety of organic compounds. The automated synthesizer is ingeniously designed to perform most of the chemical reactions currently used by synthetic organic chemists and utilizes a centrifugal separator to efficiently achieve liquid-liquid extraction. The design of the hardware and software will be described in this paper, and several examples of organic reactions will also be presented as applications of the apparatus.
authors.affiliation: Development Department, ChemGenesis Incorporated, Tokyo, Japan. kmachida@chemgenesis.com
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Machida
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Hirose
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Fuse
authors.forename: Tohru
authors.initials: T
authors.lastname: Sugawara
authors.forename: Takashi
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D001331:Automation; D002498:Centrifugation / Q000295:instrumentation* / Q000379:methods; D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D012984:Software