title: Thyroid-type solid cell nests in struma ovarii.
abstract: Solid cell nests (SCNs) of the thyroid are single or multiple foci of solid and/or cystic clusters of squamoid cells (main cells) with a minor proportion of C-cells, found in the normal thyroid. The SCNs have also been reported in the heart as an ultimobranchial heterotopia. Here, the authors describe a case of thyroid-type SCNs associated with struma ovarii. Main cells were positive for simple and stratified epithelial-type cytokeratins, carcinoembryonic antigen, carbohydrate antigen 19.9, p63, bcl-2, and galectin-3. The neuroendocrine cell population was positive for chromogranin A and synaptophysin but negative for calcitonin, suggesting a common ancestor cell capable of dual differentiation toward thyroid follicular cells and hindgut-type endocrine cells. The existence of thyroid-type SCNs in struma ovarii could be easily understood by considering the struma ovarii as a teratoma; at the same time, these findings also support the idea of a close histogenetic link between the main cells of SCNs and thyroid tissue.
authors.affiliation: Hospital Clínico Universitario, Galician Health Service, University of Santiago de Compostela, Galicia, Spain. josemanuel.cameselle@usc.es
authors.forename: José
authors.initials: J
authors.lastname: Cameselle-Teijeiro
authors.forename: Nuria
authors.initials: N
authors.lastname: Caramés
authors.forename: Alfredo
authors.initials: A
authors.lastname: Romero-Rojas
authors.forename: Rosa
authors.initials: R
authors.lastname: Reyes-Santías
authors.forename: Magalí
authors.initials: M
authors.lastname: Piso-Neira
authors.forename: Ignacio
authors.initials: I
authors.lastname: Bernabeu
authors.forename: Ihab
authors.initials: I
authors.lastname: Abdulkader
mesh_terms: D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D013330:Struma Ovarii / Q000378:metabolism / Q000473:pathology*