title: XRCC3 5'-UTR and IVS5-14 polymorphisms and breast cancer susceptibility: a meta-analysis.
abstract: Published data on the association between XRCC3 5'-UTR and IVS5-14 polymorphisms and breast cancer risk are inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. Crude ORs with 95% CIs were used to assess the strength of association between these polymorphisms and breast cancer risk. The pooled ORs were performed for codominant model, dominant model, and recessive model, respectively. A total of four studies were involved in the meta-analysis with 6,303 cases and 6,563 controls for XRCC3 5'-UTR polymorphism and with 6,270 cases and 6,682 controls for XRCC3 IVS5-14 polymorphism. For XRCC3 5'-UTR A/G polymorphism, significantly elevated breast cancer risk was associated with variant genotype when all studies were pooled into the meta-analysis (AG vs. AA: OR = 1.11, 95% CI = 1.03-1.19; dominant model: OR = 1.09, 95% CI = 1.01-1.17). For XRCC3 IVS5-14 A/G polymorphism, significantly decreased breast cancer risk was associated with variant genotype (GG vs. AA: OR = 0.86, 95% CI = 0.77-0.96). In conclusion, this meta-analysis suggests that the variant G allele of XRCC3 5'-UTR polymorphism is a low-penetrant risk factor for developing breast cancer, while the variant G allele of XRCC3 IVS5-14 polymorphism has a protective effect on breast cancer development.
authors.affiliation: Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Qiu
authors.forename: Chen
authors.initials: C
authors.lastname: Mao
authors.forename: Lei
authors.initials: L
authors.lastname: Yao
authors.forename: Ke-Da
authors.initials: KD
authors.lastname: Yu
authors.forename: Ping
authors.initials: P
authors.lastname: Zhan
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.forename: Hai-Guang
authors.initials: HG
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Yuan
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Kai
authors.initials: K
authors.lastname: Xue
authors.forename: Xi-Chun
authors.initials: XC
authors.lastname: Hu
mesh_terms: D020121:5' Untranslated Regions; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000517:prevention & control; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D020121:5' Untranslated Regions; D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3