title: MALDI-TOF MS profiling of annonaceous acetogenins in Annona muricata products for human consumption.
abstract: Annonaceous acetogenins are proposed as environmental neurotoxicants consumed through medicinal and alimentary habits and responsible for atypical parkinsonian syndromes observed in tropical areas. Potential sources of exposure still have to be determined, as, to date, only a few batches of products for human consumption were searched for these compounds. To assess the presence of acetogenins, we propose a fast, sensitive and accurate method of screening, using MALDI-TOF MS, with minimal sample preparation. Development of the technique is discussed. Its application to leaves of herbal tea, pulp and bottled nectar of Annona muricata is presented.
authors.affiliation: Laboratoire de Pharmacognosie, CNRS UMR 8076 BioCIS, Faculté de Pharmacie, Université Paris-Sud 11, Rue J. B. Clément, 92296 Châtenay-Malabry, France. pierre.champy@u-psud.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Champy
authors.forename: Vincent
authors.initials: V
authors.lastname: Guérineau
authors.forename: Olivier
authors.initials: O
authors.lastname: Laprévote
mesh_terms: D054378:Acetogenins / Q000032:analysis*; D031041:Annona / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D005502:Food; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*
chemical_list: D054378:Acetogenins