Midlife predictors of Alzheimer's disease.
Factors contributing to increased risk for Alzheimer's disease (AD) include age, sex, genes, and family history of AD. Several risk factors for AD are endogenous; however, accumulating evidence implicates modifiable risk factors in the pathogenesis of AD. Although the continued task of identifying new genes will be critical to learning more about the disease, several research findings suggest that potentially alterable environmental factors influence genetic contributions, providing targets for disease prevention and treatment. Here, we review midlife risk factors for AD, and address the potential for therapeutic intervention in midlife.
Bendlin
B B
BB
William S. Middleton Memorial Veterans Hospital, Geriatric Research Educational and Clinical Center, Madison, WI, USA. bbb@medicine.wisc.edu
Carlsson
C M
CM
Gleason
C E
CE
Johnson
S C
SC
Sodhi
A
A
Gallagher
C L
CL
Puglielli
L
L
Engelman
C D
CD
Ries
M L
ML
Xu
G
G
Wharton
W
W
Asthana
S
S
D000544:Alzheimer Disease / Q000209:etiology* / Q000235:genetics; D002318:Cardiovascular Diseases / Q000150:complications; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors; D012959:Socioeconomic Factors