title: Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage.
abstract: Liver disorders are one of the common recent problems affects on the human health. These disorders due to many environmental polluted sources. Many herbal, medicinal and pharmaceutical plants and their extracts are widely studied by many researchers. Silybum marianum got a bright reputation in relieve the liver diseases, and that might be for the potent silymarin mixture. Mechanism of action for silymarin conducted mainly to the antiradical and anticarcinogenic roles. Ethyl acetate (100mg/kg bw) and ethanol seed extracts for S. marianum (100mg/kg bw) were tested against the injection (i.p.) by carbon tetrachloride (2 ml/kg bw) the inducer of liver damage. Their activity were compared with standard hepatic drug hepaticum (100mg/kg bw) for 10 days. Ethanolic extract showed the most significantly decrease in the liver enzymes. For the oxidative experiments, ethyl acetate showed the most increase for glutathione level and the risk factor HDL/LDL significantly. Hepaticum was the most powerful group for the significant decreasing for malondialdehyde and fucosidase activity. Some equal improvements were noticed in the histopathological studies for the protective groups.
authors.affiliation: Agric Chem Dept, Agric College, Minia University, Egypt. eshaker10@hotmail.com
authors.forename: E
authors.initials: E
authors.lastname: Shaker
authors.forename: H
authors.initials: H
authors.lastname: Mahmoud
authors.forename: S
authors.initials: S
authors.lastname: Mnaa
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology / Q000517:prevention & control*; D018797:Cell Cycle Proteins / Q000502:physiology; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000517:prevention & control*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D050356:Lipid Metabolism / Q000187:drug effects; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000473:pathology / Q000517:prevention & control; D008111:Liver Function Tests; D008297:Male; D020944:Silybum marianum / Q000737:chemistry*; D009336:Necrosis; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012838:Silymarin / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D018797:Cell Cycle Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D010936:Plant Extracts; D012838:Silymarin