A facile synthesis of 2,4-disubstituted thiazoles using MnO2.
Structurally diverse thiazoles with electron-donating and electron-withdrawing groups were conveniently synthesized through manganese dioxide (MnO(2)) oxidation of the corresponding thiazolines. The effect of substitution at the 2- and 4-positions was investigated. The desired thiazoles with aryl or vinyl substitutions at the 2- or 4-position can be obtained in good to excellent yields.
Yu
Yan-Bo
YB
Department of Applied Chemistry, China Agricultural University, 100193, Beijing, China. yuyanbo0902@163.com
Chen
Hong-Liang
HL
Wang
Li-Yi
LY
Chen
Xin-Zheng
XZ
Fu
Bin
B
D009682:Magnetic Resonance Spectroscopy; D017895:Manganese Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry
D017895:Manganese Compounds; D010087:Oxides; D013844:Thiazoles; C027424:manganese oxide