New antioxidant flavonoid isolated from Leuzea carthamoides.
A new natural flavonoid patuletin 3'-beta-xylofuranoside was isolated from Leuzea carthamoides leaves. The antioxidant activity of this compound was evaluated by the DPPH radical assay and ferric reducing antioxidant power (FRAP) assay, and the results were compared with those for trolox and quercetin. DPPH radical scavenging activity of the tested compounds was expressed by the parameter EC50: patuletin 3'-beta-xylofuranoside (56.0 microM), trolox (27.8 microM), and quercetin (25.3 microM). The ferric reducing activity of the compounds was demonstrated as FRAP values at 4 and 60 min: patuletin 3'-beta-xylofuranoside (28.4 microM, 35.8 microM), trolox (19.3 microM, 20.2 microM), and quercetin (54.3 microM, 79.9 microM). The structure/activity relationship of the flavonoid is also discussed. The results indicate significant antioxidant potency of patuletin 3'-beta-xylofuranoside.
Koleckar
Vit
V
Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic.
Opletal
Lubomir
L
Macakova
Katerina
K
Jahodar
Ludek
L
Jun
Daniel
D
Kunes
Jiri
J
Kuca
Kamil
K
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D043843:Leuzea / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D000975:Antioxidants; D005419:Flavonoids