Model reduction using wavelet multiresolution technique applied to fluorescence diffuse optical tomography.
Fluorescence diffuse optical tomography is a powerful tool for the investigation of molecular events in studies for new therapeutic developments. Here, the stress is put on the mathematical problem of tomography, which can be formulated in terms of an estimation of physical parameters appearing as a set of partial differential equations and solved by the finite element method. This method is well known to be time consuming, and our principal objective is to reduce the model in order to speed up computation. A method based on a wavelet multiresolution technique is presented in detail. A validation study was conducted on synthetic data and experiments.
Landragin-Frassati
Anne
A
LETI-CEA-MINATEC, Micro-Technologies for Biology and Healthcare Division, 17 Rue des Martyrs, F-38054 Grenoble Cedex 9, France. a.frassati@wanadoo.fr
Dinten
Jean-Marc
JM
Georges
Didier
D
Da Silva
Anabela
A
D000465:Algorithms; D003198:Computer Simulation; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008856:Microscopy, Fluorescence / Q000379:methods*; D008954:Models, Biological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000379:methods*