title: [Chemical constituents of Momordica charantia L].
abstract: Momordica charantia L. is a vegetable widely cultivated around the world. Its fruits have been used in Asian countries as a folk medicine for the treatment of non-insulin-dependent diabetes mellitus. Here we report eight compounds isolated from the fruits of M. charantia. On the basis of NMR and MS spectroscopic analyses, these compounds were identified as momordicolide ((10E)-3-hydroxyl-dodeca-10-en-9-olide, 1), monordicophenoide A (4-hydroxyl-benzoic acid 4-O-beta-D-apiofuranosyl (1 --> 2)-O-beta-D-glucopyranoside, 2), dihydrophaseic acid 3-O-beta-D-glucopyranoside (3), 6,9-dihydroxy-megastigman-4,7-dien-3-one (blumenol, 4), guanosine (5), adenosine (6), uracil (7) and cytosine (8). Among them, 1 and 2 are new compounds. Compounds 3-5 were isolated from this plant for the first time.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
authors.forename: Qing-Yan
authors.initials: QY
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Liang
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Yu-Ying
authors.initials: YY
authors.lastname: Zhao
mesh_terms: D005638:Fruit / Q000737:chemistry; D006027:Glycosides / Q000032:analysis / Q000737:chemistry; D029777:Momordica charantia / Q000737:chemistry*; D014315:Triterpenes / Q000032:analysis / Q000737:chemistry
chemical_list: D006027:Glycosides; D014315:Triterpenes