title: Discoveries from the Abyss: The Abyssomicins and Their Total Synthesis.
abstract: Abyssomicin C is a recently discovered antibiotic with promising antibacterial activity, high structural complexity, and a novel mechanism of action. We give an account of our abyssomicin campaign and some of the discoveries that were borne of our total synthesis efforts, including a new Lewis acid-templated Diels-Alder reaction, the previously undescribed atrop-abyssomicin C, a facile Brønsted acid-catalyzed isomerization of abyssomicin C, and clarification of the likely biosynthetic origin of abyssomicin D.
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 & Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093.
authors.forename: K C
authors.initials: KC
authors.lastname: Nicolaou
authors.forename: Scott T
authors.initials: ST
authors.lastname: Harrison
authors.forename: Jason S
authors.initials: JS
authors.lastname: Chen