[Localization of human cytomegalovirus immediate-early protein IE-1 pp72 in the juxtanuclear inclusion at the late stage of infection].
Immediate-early protein IE-1 pp72 is one of the most abundant proteins at the early stage of human cytomegalovirus infection and has a number of intranuclear activities. This paper gives immunocytochemical and ultrastructural data on IE-1 pp72 accumulation in the juxtanuclear inclusion at the late stage of low-multiplicity infection. Detection of a new localization site infers that this protein may participate in the final steps of virus morphogenesis and play a functional role in the pathogenesis of cytomegalovirus infection.
Naumenko
V A
VA
Manykin
A A
AA
Gushchina
E A
EA
Fedorova
N E
NE
Pavlova
M V
MV
Kushch
A A
AA
D002467:Cell Nucleus / Q000378:metabolism / Q000821:virology; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000378:metabolism*; D003586:Cytomegalovirus Infections / Q000378:metabolism / Q000821:virology*; D003593:Cytoplasm / Q000378:metabolism / Q000821:virology*; D005347:Fibroblasts / Q000378:metabolism / Q000821:virology; D005455:Fluorescent Antibody Technique; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics / Q000378:metabolism*; D007181:Inclusion Bodies, Viral / Q000378:metabolism* / Q000648:ultrastructure; D008854:Microscopy, Electron; D014779:Virus Replication
C088645:IE1 protein, cytomegalovirus; D017874:Immediate-Early Proteins