Complete resolution of universal calcinosis in a patient with juvenile dermatomyositis using pamidronate.
A 14-year-old girl with juvenile dermatomyositis developed extensive and debilitating calcinosis, unresponsive to colchicine, while muscle involvement subsided. Pamidronate (2mg/kg/year) produced dramatic improvement of pain and function within 2 months and calcinosis had completely resolved by 2 years. No new calcifications have been noted with a 5-year follow-up.
Slimani
Samy
S
Department of Rheumatology, Ben Aknoun Hospital, rue des Deux-Bassins, Ben Aknoun, 16300 Algiers, Algeria. slimani@dr.com
Abdessemed
Amina
A
Haddouche
Assia
A
Ladjouze-Rezig
Aicha
A
D000293:Adolescent; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D002118:Calcium / Q000008:administration & dosage; D002762:Cholecalciferol / Q000008:administration & dosage; D003882:Dermatomyositis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004164:Diphosphonates / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D000077268:Pamidronate; D011859:Radiography; D020127:Recovery of Function; D016896:Treatment Outcome
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D002762:Cholecalciferol; D000077268:Pamidronate; D002118:Calcium; D008775:Methylprednisolone