title: [Protective role of leptin in acute gastric ulcers].
abstract: There are few data concerning protective effects of leptin on gastric epithelium treated with necrotic factors: ethanol, bile salts and hiperosmotic solutions. Further investigations are needed to establish the role of hormone leptin in gastroprotection and in the process of chronic gastric ulcers healing in animals. Exogenous leptin administration plays protective effects against 75% ethanol damage in gastric epithelium. Nitric oxide is involved in gastroprotective effects of leptin and CCK.
authors.affiliation: Katedra Fizjologii, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków, Poland. agata.ptak-belowska@uj.edu.pl
authors.forename: Agata
authors.initials: A
authors.lastname: Ptak-Belowska
authors.forename: Tomasz
authors.initials: T
authors.lastname: Brzozowski
authors.forename: Robert
authors.initials: R
authors.lastname: Pajdo
authors.forename: Michał
authors.initials: M
authors.lastname: Pawlik
authors.forename: Sławomir
authors.initials: S
authors.lastname: Kwiecień
authors.forename: Danuta
authors.initials: D
authors.lastname: Drozdowicz
authors.forename: Wiesław W
authors.initials: WW
authors.lastname: Pawlik
mesh_terms: D000208:Acute Disease; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D005753:Gastric Mucosa / Q000378:metabolism*; D020738:Leptin / Q000008:administration & dosage* / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000378:metabolism* / Q000517:prevention & control
chemical_list: D000897:Anti-Ulcer Agents; D020738:Leptin