title: Wavefront analysis, contrast sensitivity, and depth of focus after cataract surgery with aspherical intraocular lens implantation.
abstract: OBJECTIVE
  To determine whether implantation of an aspherical intraocular lens (IOL) results in reduced ocular aberrations and improved contrast sensitivity after cataract surgery without critical reduction of depth of focus.
  
  
  METHODS
  Double-blinded, randomized, prospective study.
  
  
  METHODS
  In an intraindividual study of 25 patients with bilateral cataract, an aspherical IOL (Akreos Advanced Optic [AO]; Bausch & Lomb, Inc., Rochester, New York, USA) was implanted in one eye and a spherical IOL (Akreos Fit; Bausch & Lomb, Inc) in the fellow eye. Higher-order aberrations with a 5- and 6-mm pupil were measured with a dynamic retinoscopy aberrometer at 1 and 3 months after surgery. Uncorrected and best-corrected visual acuity and contrast sensitivity under mesopic and photopic conditions also were measured. Distance-corrected near and intermediate visual acuity were studied as a measurement of depth of focus.
  
  
  RESULTS
  There was no statistically significant difference between eyes in uncorrected and best-corrected visual acuity at 1 and 3 months after surgery. There was a statistically significant between-group difference in contrast sensitivity under photopic conditions at 12 cycles per degree and under mesopic conditions at all spatial frequencies. The Akreos AO group obtained statistically significant lower values of higher-order aberrations and spherical aberration with 5- and 6-mm pupils compared with the Akreos Fit group (P < .05). There was no significant difference in distance-corrected near and intermediate visual acuity between both groups.
  
  
  CONCLUSIONS
  Aspherical aberration-free Akreos AO IOL induced significantly less higher-order aberrations and spherical aberration than the Akreos Fit. Contrast sensitivity was better under mesopic conditions with the Akreos AO with similar results of depth of focus.
authors.affiliation: Department of Ophthalmology, University of São Paulo, São Paulo, Brazil. marconysanthiago@hotmail.com
authors.forename: Marcony R
authors.initials: MR
authors.lastname: Santhiago
authors.forename: Marcelo V
authors.initials: MV
authors.lastname: Netto
authors.forename: Jackson
authors.initials: J
authors.lastname: Barreto
authors.forename: Beatriz A F
authors.initials: BA
authors.lastname: Gomes
authors.forename: Adriana
authors.initials: A
authors.lastname: Mukai
authors.forename: Ana Paula Calil
authors.initials: AP
authors.lastname: Guermandi
authors.forename: Newton
authors.initials: N
authors.lastname: Kara-Junior
mesh_terms: D057128:Aberrometry; D015350:Contrast Sensitivity / Q000502:physiology*; D057108:Corneal Wavefront Aberration / Q000503:physiopathology* / Q000517:prevention & control; D003867:Depth Perception / Q000502:physiology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D011446:Prospective Studies; D011474:Prosthesis Design; D019591:Pseudophakia / Q000503:physiopathology*; D042262:Retinoscopy; D011795:Surveys and Questionnaires; D014792:Visual Acuity / Q000502:physiology