Sustained release tablets containing soluble polymethacrylates: comparison with tableted polymethacrylate IPEC polymers.
The objective of this study was to compare a novel sustained release tablet formulation that has the potential to be used for drugs of different physicochemical properties using a binary mixture of polymethacrylate polymers in their salt forms with the polymethacrylate interpolyelectrolyte complex (IPEC) tablets in terms of drug release and compactness. Also, we aimed to compare this formulation with an IPEC tablet in terms of drug release. Tablets prepared using Eudragit E-Citrate and Eudragit L-Sodium were more convenient, easier to prepare, and showed better sustained release and compactness characteristics compared to IPEC tablets of similar concentrations and preparation methods.
Obeidat
Wasfy M
WM
College of Pharmacy, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates. wobeidat@sharjah.ac.ae
Abuznait
Alaa H
AH
Sallam
Al-Sayed A
AS
D002626:Chemistry, Pharmaceutical; D004364:Pharmaceutical Preparations; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D013607:Tablets
D004364:Pharmaceutical Preparations; D011108:Polymers; D011109:Polymethacrylic Acids; D013607:Tablets; C038300:methylmethacrylate-methacrylic acid copolymer; C030613:polymethacrylic acid