title: Anti-influenza diarylheptanoids from the bark of Alnus japonica.
abstract: This study to investigate anti-influenza components from the bark of Alnus japonica resulted in the isolation of two rare acylated diarylheptanoids, named oregonoyl A (5) and oregonoyl B (6), along with nine known compounds (1-4 and 7-11). Their structures were elucidated on the basis of extensive spectroscopic and chemical methods. Antiviral testing of compounds 1-11 against KBNP-0028 (H9N2) avian influenza virus showed that platyphyllone (10) was strongly active, and platyphyllonol-5-xylopyranoside (9) was moderately active against KBNP-0028 as compared with the positive control, zanamivir, respectively.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
authors.forename: Nguyen Huu
authors.initials: NH
authors.lastname: Tung
authors.forename: Hyuk-Joon
authors.initials: HJ
authors.lastname: Kwon
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Kim
authors.forename: Jeong Chan
authors.initials: JC
authors.lastname: Ra
authors.forename: Yan
authors.initials: Y
authors.lastname: Ding
authors.forename: Jeong Ah
authors.initials: JA
authors.lastname: Kim
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D029661:Alnus; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002642:Chick Embryo; D036381:Diarylheptanoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D053127:Influenza A Virus, H9N2 Subtype / Q000187:drug effects* / Q000502:physiology; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D036381:Diarylheptanoids; D010936:Plant Extracts