title: Sonozaki syndrome: case report and review of literature.
abstract: Sonozaki syndrome--pustulotic arthro-osteitis (PAO) is a relatively rare, chronic illness. This disease belongs to the group of psoriatic arthritis (psoriasis arthropatica, artropatia psoriatica) which in turn belongs to the group of seronegative arthritis. Sonozaki syndrome includes palmoplantar pustulosis, PPP as well as arthro-osteitis. Clinically, symmetrically localised pustulae are observed on feet and hands. Effected joints are painful, swollen with a visible inflammation. Here, we describe a case of a woman aged 55 with a diagnosis of Sonozaki syndrome and hyperthyroidism. At the moment of admission multiple changes in the form of pustulae were observed on hands and soles, filled with pus and blood of the erythemal basis. Oral and genital mucosa were free from changes. The oedema within clavicle and sternum joints was without features of the severe inflammation and tactical tenderness. In additional tests, increased BSR 36/62 was found. Bone scintigraphy-focuses of increased accumulation of MDP-Tc-99 m were found in the sternal projection of the clavicle ends at both sides, and the left-side change is bigger and more strongly saturated and can probably progress to the sternum's manubrium. As a result of the used treatment during hospitalisation, (cyclosporine 3 mg/kg and steroid external therapy upon the skin changes) the improvement of the local changes was observed as well as no progression in the joints' changes. At the moment, the patient is treated in the dermatological and rheumatological out-clinic. Early and correct diagnostics allows for efficient treatment of Sonozaki syndrome and decreases the risk of potential complications, such as the described systemic amyloidosis.
authors.affiliation: Department of Dermatology, Silesian Medical University in Katowice, Francuska Street 20/24, 40-027 Katowice, Poland.
authors.forename: Ligia
authors.initials: L
authors.lastname: Brzezińska-Wcisło
authors.forename: Beata
authors.initials: B
authors.lastname: Bergler-Czop
authors.forename: Anna
authors.initials: A
authors.lastname: Lis-Święty
mesh_terms: D015535:Arthritis, Psoriatic / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology*; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D055420:Perfusion Imaging / Q000379:methods; D011565:Psoriasis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology*; D013247:Sternoclavicular Joint / Q000000981:diagnostic imaging / Q000473:pathology; D013577:Syndrome
chemical_list: D016572:Cyclosporine