title: [A resected case of pathologically complete response of a pelvic recurrence from rectal cancer after chemoradiotherapy with S-1].
abstract: The patient was a 58-year-old man who had been performed a low anterior resection for an advanced upper rectal cancer (T3N0M0, Stage II). At fourteen months after primary operation, follow-up CT scan, MRI and FDG-PET showed a pelvic recurrence located at upper presacral region. Following radiotherapy combined with S-1, we performed a curative surgical resection. Pathologically, an extensive fibrosis was shown without a tumor cell. Complete surgical removal of the recurrent disease remains the best chance of cure after a local recurrence. But in the case of recurrent tumor located in upper presacral region and extended to the pelvic side-wall, it is very difficult to achieve negative resection margins. So selection of patients is very important to reduce the risk of positive surgical margins. We experienced a resected case of pathologically complete response of a pelvic recurrence from rectal cancer after chemoradiotherapy with S-1. This case suggests the neoadjuvant chemoradiotherapy has potential to improve management of locally recurrent rectal cancer.
authors.affiliation: Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: Manabu
authors.initials: M
authors.lastname: Ohashi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Iwanaga
authors.forename: Keiichi
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local; D010094:Oxonic Acid / Q000627:therapeutic use*; D010388:Pelvis; D012004:Rectal Neoplasms / Q000628:therapy*; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid