Role of Oct-4 during acquisition of developmental competence in mouse oocyte.
Knowledge of what determines the developmental competence of oocytes during folliculogenesis is poor. This review, through the analysis of the expression profile of developmentally competent or incompetent mouse oocytes, summarizes the results of recent studies showing that the Oct-4 transcription factor regulating the expression of Stella and Foxj2 at the Nanog locus could play a pivotal role in the establishment of the oocyte's developmental competence.
Zuccotti
Maurizio
M
Sezione di Istologia ed Embriologia, Dipartimento di Medicina Sperimentale, Universita' degli Studi di Parma, Parma, Italy.
Merico
Valeria
V
Redi
Carlo Alberto
CA
Bellazzi
Riccardo
R
Adjaye
James
J
Garagna
Silvia
S
D000818:Animals; D002868:Chromosomal Proteins, Non-Histone; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D050814:Octamer Transcription Factor-3 / Q000502:physiology*; D009865:Oocytes / Q000254:growth & development* / Q000378:metabolism; D011506:Proteins / Q000235:genetics / Q000378:metabolism
D002868:Chromosomal Proteins, Non-Histone; C466105:DPPA3 protein, human; C408469:FOXJ2 protein, human; D051858:Forkhead Transcription Factors; D050814:Octamer Transcription Factor-3; D011506:Proteins