title: Life threatening protamine reaction during bypass surgery--a case report.
abstract: An anaphylactic reaction to protamine sulphate during cardiac surgery is a rare but known entity. Preoperative prediction and outcome of such a reaction is still unclear. We report a case of severe anaphylactic reaction to protamine sulphate in a diabetic while performing beating heart bypass surgery. We also reviewed the literature and discussed the management of such cases.
authors.affiliation: Department of Cardiovascular Surgery, Apollo Hospitals, Chennai - 600 006, India. drdkm2002@yahoo.com
authors.forename: Dillip Kumar
authors.initials: DK
authors.lastname: Mishra
authors.forename: I
authors.initials: I
authors.lastname: Sathyamurthy
authors.forename: K
authors.initials: K
authors.lastname: Subramanyan
authors.forename: M R
authors.initials: MR
authors.lastname: Girinath
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000628:therapy; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D017809:Fatal Outcome; D006494:Heparin Antagonists / Q000009:adverse effects*; D006801:Humans; D007431:Intraoperative Complications / Q000139:chemically induced* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011479:Protamines / Q000009:adverse effects*; D012307:Risk Factors
chemical_list: D006494:Heparin Antagonists; D011479:Protamines