title: In vivo early detection of smoke-induced airway injury using three-dimensional swept-source optical coherence tomography.
abstract: We report on the feasibility of rapid, high-resolution, 3-D swept-source optical coherence tomography (SSOCT) to detect early airway injury changes following smoke inhalation exposure in a rabbit model. The SSOCT system obtains 3-D helical scanning using a microelectromechanical system motor-based endoscope. Real-time 2-D data processing and image display at the speed of 20 frames/s are achieved by adopting the technique of parallel computing. Longitudinal images are reconstructed via an image processing algorithm to remove motion artifacts caused by ventilation and pulse. Quantitative analyses of tracheal airway thickness as well as thickness distribution along tracheal circumference are also performed based on the comprehensive 3-D volumetric data.
authors.forename: Jiechen
authors.initials: J
authors.lastname: Yin
authors.forename: Gangjun
authors.initials: G
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Lingfeng
authors.initials: L
authors.lastname: Yu
authors.forename: Sari
authors.initials: S
authors.lastname: Mahon
authors.forename: David
authors.initials: D
authors.lastname: Mukai
authors.forename: Matthew
authors.initials: M
authors.lastname: Brenner
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000465:Algorithms; D000818:Animals; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D011817:Rabbits; D012680:Sensitivity and Specificity; D015208:Smoke Inhalation Injury / Q000175:diagnosis* / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*; D014132:Trachea / Q000473:pathology