title: Effect of breast compression on lesion characteristic visibility with diffraction-enhanced imaging.
abstract: OBJECTIVE
  Conventional mammography can not distinguish between transmitted, scattered, or refracted x-rays, thus requiring breast compression to decrease tissue depth and separate overlapping structures. Diffraction-enhanced imaging (DEI) uses monochromatic x-rays and perfect crystal diffraction to generate images with contrast based on absorption, refraction, or scatter. Because DEI possesses inherently superior contrast mechanisms, the current study assesses the effect of breast compression on lesion characteristic visibility with DEI imaging of breast specimens.
  
  
  METHODS
  Eleven breast tissue specimens, containing a total of 21 regions of interest, were imaged by DEI uncompressed, half-compressed, or fully compressed. A fully compressed DEI image was displayed on a soft-copy mammography review workstation, next to a DEI image acquired with reduced compression, maintaining all other imaging parameters. Five breast imaging radiologists scored image quality metrics considering known lesion pathology, ranking their findings on a 7-point Likert scale.
  
  
  RESULTS
  When fully compressed DEI images were compared to those acquired with approximately a 25% difference in tissue thickness, there was no difference in scoring of lesion feature visibility. For fully compressed DEI images compared to those acquired with approximately a 50% difference in tissue thickness, across the five readers, there was a difference in scoring of lesion feature visibility. The scores for this difference in tissue thickness were significantly different at one rocking curve position and for benign lesion characterizations. These results should be verified in a larger study because when evaluating the radiologist scores overall, we detected a significant difference between the scores reported by the five radiologists.
  
  
  CONCLUSIONS
  Reducing the need for breast compression might increase patient comfort during mammography. Our results suggest that DEI may allow a reduction in compression without substantially compromising clinical image quality.
authors.affiliation: Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Laura S
authors.initials: LS
authors.lastname: Faulconer
authors.forename: Chris A
authors.initials: CA
authors.lastname: Parham
authors.forename: Dean M
authors.initials: DM
authors.lastname: Connor
authors.forename: Cherie
authors.initials: C
authors.lastname: Kuzmiak
authors.forename: Marcia
authors.initials: M
authors.lastname: Koomen
authors.forename: Yeonhee
authors.initials: Y
authors.lastname: Lee
authors.forename: Kyu Ran
authors.initials: KR
authors.lastname: Cho
authors.forename: Josh
authors.initials: J
authors.lastname: Rafoth
authors.forename: Chad A
authors.initials: CA
authors.lastname: Livasy
authors.forename: Eunhee
authors.initials: E
authors.lastname: Kim
authors.forename: Donglin
authors.initials: D
authors.lastname: Zeng
authors.forename: Elodia
authors.initials: E
authors.lastname: Cole
authors.forename: Zhong
authors.initials: Z
authors.lastname: Zhong
authors.forename: Etta D
authors.initials: ED
authors.lastname: Pisano
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D010812:Physical Stimulation / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014961:X-Ray Diffraction / Q000379:methods*