Wnt signaling in mitosis.
Previously, the connection between cell proliferation and Wnt signaling focused on transcriptional activation of cyclin D1 and c-myc, which control the G1/S transition of the cell cycle. In this issue of Developmental Cell, the Niehrs group demonstrates mitotic activation of Wnt signaling by a novel Cdk/cyclin complex containing Cdk14 (PFTK1) and cyclin Y.
Kaldis
Philipp
P
Institute of Molecular and Cell Biology (IMCB), Cell Division and Cancer Laboratory (PRK), 61 Biopolis Drive, Proteos #03-09, Singapore 138673, Republic of Singapore. kaldis@imcb.a-star.edu.sg
Pagano
Michele
M
D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism; D002453:Cell Cycle; D016213:Cyclins / Q000378:metabolism; D008938:Mitosis; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*
D016213:Cyclins; D051153:Wnt Proteins; D016203:CDC2 Protein Kinase