Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation in prostate cancer.
A mechanism for survival of prostate cancer cells in an androgen-deprived environment remains elusive. Here, we find that expression of neuronal apoptosis inhibitory protein (NAIP) was significantly increased in vivo and in vitro in response to androgen deprivation therapy (ADT). Increased expression of NAIP corresponded to increased DNA-binding activity of NF-kappaB that physically associated to previously uncharacterized kappaB-like sites in the NAIP locus. Importantly, expression of NAIP was significantly increased (p=0.04) in clinical samples of prostate cancer from patients receiving ADT. Expression of NAIP may be associated with enhanced survival of prostate cancer in response to castration.
Chiu
Helen H L
HH
Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia, Canada V5Z 1L3.
Yong
Theresa M K
TM
Wang
Jun
J
Wang
Yuwei
Y
Vessella
Robert L
RL
Ueda
Takeshi
T
Wang
Yu-Zhuo
YZ
Sadar
Marianne D
MD
D000728:Androgens / Q000378:metabolism*; D015153:Blotting, Western; D002369:Castration; D047369:Chromatin Immunoprecipitation; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D016328:NF-kappa B / Q000378:metabolism; D051616:Neuronal Apoptosis-Inhibitory Protein / Q000235:genetics / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
D000728:Androgens; D016328:NF-kappa B; D051616:Neuronal Apoptosis-Inhibitory Protein; D012333:RNA, Messenger