title: Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida.
abstract: Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC(50)) at a concentration of less than 1 microM, and 3 showed gelatinases A and B inhibitory activity (IC(50)) at 0.4 and 2.3 microM, respectively.
authors.affiliation: Inam Neuroscience Research Center, Wonkwang University Sanbon Medical Center, Sanbon-dong, Gunpocity, Kyunggi-Do 435-040, South Korea.
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Moon
authors.forename: Tae-im
authors.initials: TI
authors.lastname: Kim
authors.forename: Hyun-Soo
authors.initials: HS
authors.lastname: Cho
authors.forename: Eung Kweon
authors.initials: EK
authors.lastname: Kim
mesh_terms: D017364:Collagenases / Q000378:metabolism; D027825:Crataegus; D018093:Gelatinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D010936:Plant Extracts; D017364:Collagenases; D018093:Gelatinases