title: Is familiality associated with downward occupation drift in schizophrenia?
abstract: OBJECTIVE
  Downward occupational drift has been extensively investigated in schizophrenia. It is known that certain illness related factors, such as severity, affect drift, but the impact of familial factors has not been investigated.
  
  
  METHODS
  Occupation drift was studied among patients with schizophrenia/schizoaffective disorder (SZ/SZA)(n=523) and 130 affected sib pairs (ASPs). Drift was analyzed in relation to familiality as well as demographic and clinical variables. For comparison one proband (one of the affected siblings) from each ASP was selected. Occupation drift was measured in relation to the most responsible job held, and with regard to head of the household (HOH) occupation status.
  
  
  RESULTS
  There was no significant difference between single affected and ASP probands in terms of occupational drift from the most responsible job (drifted 39.2% and 38% respectively) and with regard to HOH's occupation (drifted 88% and 82.8% respectively). A significant part of the sample remained unemployed in both single affected and ASP samples. Thus, there was no significant impact of familiality on these variables. However, marital status, pattern of severity, age at onset, gender were found to be associated with downward occupation drift in single affected probands while the only significant factor in familial probands was pattern of severity of severity when measuring in terms of downward drift from most responsible job.
  
  
  CONCLUSIONS
  Though there is occupation drift in schizophrenia, there is no detectable impact of familial factors. Employment is associated with severity of delete.
authors.affiliation: Training Program for Psychiatric Genetics in India, Dr RML Hospital, New Delhi, India.
authors.forename: Triptish
authors.initials: T
authors.lastname: Bhatia
authors.forename: Satabdi
authors.initials: S
authors.lastname: Chakraborty
authors.forename: Pramod
authors.initials: P
authors.lastname: Thomas
authors.forename: Amina
authors.initials: A
authors.lastname: Naik
authors.forename: Sati
authors.initials: S
authors.lastname: Mazumdar
authors.forename: Vishwajit L
authors.initials: VL
authors.lastname: Nimgaonkar
authors.forename: Smita N
authors.initials: SN
authors.lastname: Deshpande