Rapid sequencing of individual DNA molecules in graphene nanogaps.
I propose a technique for reading the base sequence of a single DNA molecule using a graphene nanogap to read the DNA's transverse conductance. Because graphene is a single atom thick, single-base resolution of the conductance is readily obtained. The nonlinear current-voltage characteristic is used to determine the base type independent of nanogap-width variations that cause the current to change by 5 orders of magnitude. The expected sequencing error rate is 0% up to a nanogap width of 1.6 nm.
Postma
Henk W Ch
HW
Department of Physics, California State University Northridge, 18111 Nordhoff Street, Northridge, California 91330-8268, USA. postma@csun.edu
D001427:Bacterial Toxins / Q000737:chemistry / Q000235:genetics; D002244:Carbon / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000235:genetics; D004594:Electrophysiology / Q000379:methods; D006460:Hemolysin Proteins / Q000737:chemistry / Q000235:genetics; D015233:Models, Statistical; D036103:Nanotechnology / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods*; D012822:Silicon Dioxide / Q000737:chemistry; D013269:Stochastic Processes
D001427:Bacterial Toxins; D004277:DNA, Single-Stranded; D006460:Hemolysin Proteins; C021091:staphylococcal alpha-toxin; D002244:Carbon; D012822:Silicon Dioxide; D004247:DNA