title: Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo.
abstract: Attacking angiogenesis is considered an effective strategy for controls the expansion and metastasis of tumors and other related-diseases. The aim of this study was to assess the effects of moscatilin, a bibenzyl derivative, on VEGF and bFGF-induced angiogenesis in cultured human umbilical vein endothelial cells (HUVECs) in vitro and in vivo. Moscatilin significantly inhibited growth of lung cancer cell line A549 (NSCLC) and suppressed growth factor-induced neovascularization. In addition, VEGF- and bFGF-induced cell proliferation, migration, and tube formation of HUVECs was markedly inhibited by moscatilin. Western blotting analysis of cell signaling molecules indicated that moscatilin inhibited ERK1/2, Akt, and eNOS signaling pathways in HUVECs. These results suggest that inhibition of angiogenesis by moscatilin may be a major mechanism in cancer therapy.
authors.affiliation: Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: An-Chi
authors.initials: AC
authors.lastname: Tsai
authors.forename: Shiow-Lin
authors.initials: SL
authors.lastname: Pan
authors.forename: Cho-Hwa
authors.initials: CH
authors.lastname: Liao
authors.forename: Jih-Hwa
authors.initials: JH
authors.lastname: Guh
authors.forename: Shih-Wei
authors.initials: SW
authors.lastname: Wang
authors.forename: Hui-Lung
authors.initials: HL
authors.lastname: Sun
authors.forename: Yi-Nan
authors.initials: YN
authors.lastname: Liu
authors.forename: Chien-Chih
authors.initials: CC
authors.lastname: Chen
authors.forename: Chien-Chang
authors.initials: CC
authors.lastname: Shen
authors.forename: Ya-Ling
authors.initials: YL
authors.lastname: Chang
authors.forename: Che-Ming
authors.initials: CM
authors.lastname: Teng
mesh_terms: D000818:Animals; D001593:Benzyl Compounds / Q000494:pharmacology*; D015153:Blotting, Western; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D031667:Dendrobium / Q000737:chemistry*; D016222:Fibroblast Growth Factor 2 / Q000187:drug effects / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D009369:Neoplasms / Q000098:blood supply* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D010936:Plant Extracts / Q000494:pharmacology*; D042461:Vascular Endothelial Growth Factor A / Q000187:drug effects / Q000502:physiology
chemical_list: D001593:Benzyl Compounds; D010936:Plant Extracts; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; C071845:dendrophenol