[Pulmonary-renal syndrome].
The pulmonary-renal syndrome is defined as a combination of diffuse alveolar hemorrhage and glomerulonephritis. The coexistence of these two clinical conditions is due to diseases with different pathogenic mechanisms. Primary systemic vasculitis and Goodpasture syndrome are the most frequent etiologies. Systemic lupus erythematosus, connective tissue diseases, negative anti neutrophil cytoplasmic antibody vasculitis and those secondary to drugs are far less common causes. An early diagnosis based on clinical, radiologic, laboratory and histologic criteria enables early treatment, thus diminishing its high morbidity-mortality rate. Therapy is based on high doses of corticosteroids, immunosuppressants, tumor necrosis factor inhibitors and plasmapheresis.
Risso
Jorge A
JA
15ta. Cátedra, Departamento de Medicina, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Argentina.
Mazzocchi
Octavio
O
De All
Jorge
J
Gnocchi
César A
CA
D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D013577:Syndrome