title: Cognitive factors and willingness to participate in an HIV vaccine trial among HIV-negative injection drug users.
abstract: This cross-sectional study involving a cohort of injection drug users (IDU) examined the relationship between cognitive factors (HIV treatment optimism, self-efficacy and knowledge of vaccine trial concepts) as well as risk factors for seroconversion, and willingness to participate (WTP) in a preventive phase 3 HIV vaccine trial. Willingness to participate overall was 56%. In a multivariate analysis, for a 20-unit increase in a 100-point composite scale, self-efficacy was positively related to WTP (adjusted odds ratio [AOR]=1.95, 95% CI=1.40-2.70). HIV treatment optimism and knowledge of vaccine trial concepts were unrelated to WTP. Aboriginal ethnicity (AOR=3.47, 95% CI=1.68-7.18) and a higher educational level (>or=high school) (AOR=1.96, 95% CI=1.07-3.59) were positively related to WTP. This study provides information on WTP for an HIV vaccine trial. Limitations and future directions are also discussed.
authors.affiliation: School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Shayesta
authors.initials: S
authors.lastname: Dhalla
authors.forename: Gary
authors.initials: G
authors.lastname: Poole
authors.forename: Joel
authors.initials: J
authors.lastname: Singer
authors.forename: David M
authors.initials: DM
authors.lastname: Patrick
authors.forename: Evan
authors.initials: E
authors.lastname: Wood
authors.forename: Thomas
authors.initials: T
authors.lastname: Kerr
mesh_terms: D016915:AIDS Vaccines / Q000008:administration & dosage*; D000328:Adult; D001955:British Columbia; D017326:Clinical Trials, Phase III as Topic; D003430:Cross-Sectional Studies; D055030:Drug Users / Q000523:psychology*; D004522:Educational Status; D005260:Female; D015658:HIV Infections / Q000517:prevention & control* / Q000523:psychology; D006801:Humans; D007198:Indians, North American; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010358:Patient Participation / Q000523:psychology*
chemical_list: D016915:AIDS Vaccines