title: Pancreatoblastoma: two case reports from a medical center in Taiwan.
abstract: Although pancreatoblastoma (PB) is an extremely rare tumor, it is the most common pancreatic tumor in children. We reported 2 cases of PB treated at a medical center in Taiwan. One was a 3.5-year-old boy who presented with abdominal pain. Physical examination demonstrated abdominal masses. Multiple pancreatic and hepatic masses were noted by magnetic resonance imaging. He underwent surgical resection but tumor could not be removed completely, which was confirmed by the pathology. He received chemotherapy consisting of cisplatin and doxorubicin after the surgery but the tumor progressed rapidly. He died of progressive disease and sepsis. The other case was a 4-year-old boy presented with abdominal pain. Computed tomography showed pancreatic tumor. He underwent surgical resection and pathology showed PB. He received chemotherapy after complete tumor resection. He is disease free till now. Complete tumor resection is the major difference of these 2 patients and is the most important factor affecting the outcome.
authors.affiliation: Departments of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Huang
authors.forename: Yung-Li
authors.initials: YL
authors.lastname: Yang
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Hsu
authors.forename: Hong-Shiee
authors.initials: HS
authors.lastname: Lai
authors.forename: Kai-Hsin
authors.initials: KH
authors.lastname: Lin
authors.forename: Shiann-Tarng
authors.initials: ST
authors.lastname: Jou
authors.forename: Meng-Yao
authors.initials: MY
authors.lastname: Lu
authors.forename: Hsiu-Hao
authors.initials: HH
authors.lastname: Chang
authors.forename: Dong-Tsamn
authors.initials: DT
authors.lastname: Lin
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D008297:Male; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D013624:Taiwan; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D004317:Doxorubicin; D002945:Cisplatin