title: [Preparation and in vitro evaluation of brucine-loaded polylacticacid nanoparticles].
abstract: OBJECTIVE
  To prepare and evaluate brucine-loaded polylacticacid nanoparticles (Bru-PLA-NPs).
  
  
  METHODS
  The Bru-PLA-NPs were prepared by solvent diffusion method. The physical, chemical properties and in vitro release behavior of the prepared Bru-PLA-NPs were evaluated, respectively.
  
  
  RESULTS
  The mean particle size of the prepared Bru-PLA-NPs was 95 nm with polydispersity index of 0.362. The zeta potential was -15.68 mV. The mean loading and entrapment efficiency of Bru were 7% and 37%, respectively. Compared with Bru solution, an obvious sustained release behavior of Bru from Bru-PLA-NPs was observed in the in vitro release experiment.
  
  
  CONCLUSIONS
  The Bru-PLA-NPs prepared by solvent diffusion method exhibit small particle size, high Bru-loading efficiency, and obvious sustained release in vitro
authors.affiliation: Department of Pharmaceutics, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Jihui
authors.initials: J
authors.lastname: Zhao
authors.forename: Zhaolin
authors.initials: Z
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Yu
authors.forename: Nianping
authors.initials: N
authors.lastname: Feng
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D013331:Strychnine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); C083806:brucine; D013331:Strychnine