title: Experimental approaches to the study of epigenomic dysregulation in ageing.
abstract: In this review, we describe how normal ageing may involve the acquisition of epigenetic errors over time, akin to the accumulation of genetic mutations with ageing. We describe how such experiments are currently performed, their limitations technically and analytically and their application to ageing research.
authors.affiliation: Department of Genetics and Center for Epigenomics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Reid F
authors.initials: RF
authors.lastname: Thompson
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Fazzari
authors.forename: John M
authors.initials: JM
authors.lastname: Greally
mesh_terms: D000375:Aging / Q000235:genetics* / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D019175:DNA Methylation / Q000235:genetics / Q000502:physiology; D044127:Epigenesis, Genetic / Q000235:genetics* / Q000502:physiology; D006657:Histones / Q000235:genetics / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*
chemical_list: D006657:Histones