title: Vitamin A supplementation for different periods alters oxidative parameters in lungs of rats.
abstract: Lungs require an adequate supply of vitamin A (retinol) for normal embryonic development, postnatal maturation, and maintenance and repair during adult life. However, recent intervention studies revealed that supplementation with retinoids resulted in higher incidence of lung cancer, although the mechanisms underlying this effect are still unknown. Here, we studied the effect of vitamin A supplementation on oxidative stress parameters in lungs of Wistar rats. Vitamin A supplementation at either therapeutic (1,000 and 2,500 IU/kg) or excessive (4,500 and 9,000 IU/kg) doses for 3, 7, or 28 days induced lipid peroxidation, protein carbonylation, and oxidation of protein thiol groups, as well as change in catalase and superoxide dismutase activity. Together, these results suggest that vitamin A supplementation causes significant changes in redox balance, which are frequently associated with severe lung dysfunction.
authors.affiliation: Centro de Estudos em Estresse Oxidativo, Universidade Federal do Rio Grande do Sul, Departamento de Bioquímica, Porte Alegre, Rio Grande do Sul, Brazil.
authors.forename: Matheus Augusto de Bittencourt
authors.initials: MA
authors.lastname: Pasquali
authors.forename: Daniel Pens
authors.initials: DP
authors.lastname: Gelain
authors.forename: Marcos Roberto
authors.initials: MR
authors.lastname: de Oliveira
authors.forename: Guilherme Antônio
authors.initials: GA
authors.lastname: Behr
authors.forename: Leonardo Lisbôa
authors.initials: LL
authors.lastname: da Motta
authors.forename: Ricardo Fagundes
authors.initials: RF
authors.lastname: da Rocha
authors.forename: Fábio
authors.initials: F
authors.lastname: Klamt
authors.forename: José Cláudio Fonseca
authors.initials: JC
authors.lastname: Moreira
mesh_terms: D000818:Animals; D019587:Dietary Supplements / Q000009:adverse effects*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014801:Vitamin A / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014801:Vitamin A