Gd(III)-nanodiamond conjugates for MRI contrast enhancement.
A Gd(III)-nanodiamond conjugate [Gd(III)-ND] was prepared and characterized, enabling detection of nanodiamonds by MR imaging. The Gd(III)-ND particles significantly reduced the T(1) of water protons with a per-Gd(III) relaxivity of 58.82 +/- 1.18 mM(-1) s(-1) at 1.5 T (60 MHz). This represents a 10-fold increase compared to the monomer Gd(III) complex (r(1) = 5.42 +/- 0.20 mM(-1) s(-1)) and is among the highest per-Gd(III) relaxivities reported.
Manus
Lisa M
LM
Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, USA.
Mastarone
Daniel J
DJ
Waters
Emily A
EA
Zhang
Xue-Qing
XQ
Schultz-Sikma
Elise A
EA
Macrenaris
Keith W
KW
Ho
Dean
D
Meade
Thomas J
TJ
D000818:Animals; D002151:Calorimetry / Q000379:methods; D003287:Contrast Media / Q000494:pharmacology*; D018130:Diamond; D005682:Gadolinium / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008968:Molecular Conformation; D041681:NIH 3T3 Cells; D050997:Nanomedicine / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*
D003287:Contrast Media; D018130:Diamond; D005682:Gadolinium