The biocompatability of mesoporous inorganic-organic hybrid resin films with ionic and hydrophilic characteristics.
New mesoporous silicate-titania resin systems hybridized with 4,5-dihydroxy-m-benzenedisulfonic acid and poly(ethylene glycol)-dimethacrylate component were developed. These inorganic-organic hybrid resins were found to reveal highly controlled ionic and hydrophilic surface with excellent durability and adhesion onto various substrates. The resin films revealed high resistance to nonspecific adsorption of fibrinogen and to adherence by several bacterial pathogens such as Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis. Furthermore, excellent biocompatibility of the developed resins was proved by both HEp-2 cell adhesion in vitro and subcutaneous implantation in mice. The inorganic-organic hybrid resins are strongly promising for biomedical applications including biomedical devices and biosensors.
Kim
Gahee
G
Department of Chemistry, National Research Lab for Polymer Synthesis and Physics, Center for Electro-Photo Behaviors in Advanced Molecular Systems, Division of Advanced Materials Science, Pohang Accelerator Laboratory, BK School of Molecular Science, and Polymer Research Institute, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
Hong
Lan Young
LY
Jung
Jungwoon
J
Kim
Dong-Pyo
DP
Kim
Heesoo
H
Kim
Ik Jung
IJ
Kim
Jung Ran
JR
Ree
Moonhor
M
D000818:Animals; D001419:Bacteria / Q000166:cytology / Q000187:drug effects; D001422:Bacterial Adhesion / Q000187:drug effects; D001557:Benzenesulfonates / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D007477:Ions; D008422:Materials Testing / Q000379:methods*; D008689:Methacrylates / Q000494:pharmacology*; D051379:Mice; D046529:Microscopy, Electron, Transmission; D011092:Polyethylene Glycols / Q000494:pharmacology*; D016062:Porosity / Q000187:drug effects; D012117:Resins, Synthetic / Q000494:pharmacology*; D053838:Scattering, Small Angle; D014961:X-Ray Diffraction
D001557:Benzenesulfonates; D001672:Biocompatible Materials; D007477:Ions; D008689:Methacrylates; D012117:Resins, Synthetic; C421283:poly(ethylene glycol)-dimethacrylate; D011092:Polyethylene Glycols