title: Role of ADAM and ADAMTS metalloproteinases in airway diseases.
abstract: Lungs are exposed to the outside environment and therefore to toxic and infectious agents or allergens. This may lead to permanent activation of innate immune response elements. A Disintegrin And Metalloproteinases (ADAMs) and ADAMs with Thrombospondin motifs (ADAMTS) are proteinases closely related to Matrix Metalloproteinases (MMPs). These multifaceted molecules bear metalloproteinase and disintegrin domains endowing them with features of both proteinases and adhesion molecules. Proteinases of the ADAM family are associated to various physiological and pathological processes and display a wide spectrum of biological effects encompassing cell fusion, cell adhesion, "shedding process", cleavage of various substrates from the extracellular matrix, growth factors or cytokines... This review will focus on the putative roles of ADAM/ADAMTS proteinases in airway diseases such as asthma and COPD.
authors.affiliation: Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée- GIGA, University of Liège and CHU of Liège, Sart-Tilman, Belgium. gpaulissen@ulg.ac.be
authors.forename: Genevieve
authors.initials: G
authors.lastname: Paulissen
authors.forename: Natacha
authors.initials: N
authors.lastname: Rocks
authors.forename: Maud M
authors.initials: MM
authors.lastname: Gueders
authors.forename: Celine
authors.initials: C
authors.lastname: Crahay
authors.forename: Florence
authors.initials: F
authors.lastname: Quesada-Calvo
authors.forename: Sandrine
authors.initials: S
authors.lastname: Bekaert
authors.forename: Jonathan
authors.initials: J
authors.lastname: Hacha
authors.forename: Mehdi
authors.initials: M
authors.lastname: El Hour
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Foidart
authors.forename: Agnes
authors.initials: A
authors.lastname: Noel
authors.forename: Didier D
authors.initials: DD
authors.lastname: Cataldo
mesh_terms: D051722:ADAM Proteins / Q000378:metabolism*; D000818:Animals; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008171:Lung Diseases / Q000378:metabolism*; D008954:Models, Biological
chemical_list: D051722:ADAM Proteins