title: [Protecting effect of Chaenomeles speciosa broth on immunosuppressive mice induced by cyclophosphamide].
abstract: OBJECTIVE
  To investigate the effects of Chaenomeles speciosa broth on immunoregulation for anti-tumor chemotherapy.
  
  
  METHODS
  Immunosuppressive model was induced by cyclophosphamide (CTX) in mice. The mice were treated with the broth for 15 days. The serum hemolysin was observed in mouse sera. Spleen lymphocyte transformation and gene transcription related to the immunoregulation in spleen lymphocytes were detected.
  
  
  RESULTS
  After administrated the broth, the serum hemolysin and lymphocyte transformation rates significantly increased and the mRNA expression of foxp3, TGF-beta, PD1, Fas, Bax were downregulated compared with CTX-group.
  
  
  CONCLUSIONS
  Chaenomeles speciosa broth has protective effects on the immunosuppressive mouse induce by CTX.
authors.affiliation: Institute of Molecular Biology, China Three Gorges University, Yichang 443002, China. annashijijing@yahoo.com
authors.forename: Ji-jing
authors.initials: JJ
authors.lastname: Shi
authors.forename: Chao-qi
authors.initials: CQ
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Xiao-lin
authors.initials: XL
authors.lastname: Qin
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Jin-jiang
authors.initials: JJ
authors.lastname: Wang
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003520:Cyclophosphamide / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005285:Fermentation; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D005638:Fruit / Q000737:chemistry; D005786:Gene Expression Regulation / Q000187:drug effects; D006460:Hemolysin Proteins / Q000097:blood; D007108:Immune Tolerance / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011897:Random Allocation; D027824:Rosaceae / Q000737:chemistry*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D006460:Hemolysin Proteins; D012333:RNA, Messenger; D003520:Cyclophosphamide