Canine inverted papillomas associated with DNA of four different papillomaviruses.
Inverted papillomas are uncommon papillomavirus (PV)-induced canine skin lesions. They consist of cup- to dome-shaped dermal nodules with a central pore filled with keratin. Histologically they are characterized by endophytic projections of the epidermis extending into dermis. Cytopathic effects of PVs infection include the presence of clumped keratohyalin granules, koilocytes and intranuclear inclusion bodies. Different DNA hybridization studies carried out with a canine oral papillomavirus (COPV) probe suggested that a different PV than COPV might cause these lesions. Canine papillomavirus 2 (CPV2) was discovered a few years ago in inverted papillomas of immunosuppressed beagles. Two other cases, presenting with distinct clinical and histological features have also been described. This study was carried out on four dogs with clinical and histological signs of inverted papillomas. Molecular biological analyses confirmed that PV DNA was present in all four lesions but demonstrated that the sequences in each case were different. One corresponded to COPV, the second to CPV2, and the third and fourth to unknown PVs. These findings suggest that inverted papillomas are not caused by one single PV type. Similar observations have also been made in human medicine.
Lange
Christian E
CE
Clinic for Small Animal Internal Medicine, Dermatology Unit, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH-8057 Zurich, Switzerland.
Tobler
Kurt
K
Brandes
Kristin
K
Breithardt
Kristin
K
Ordeix
Laura
L
Von Bomhard
Wolfgang
W
Favrot
Claude
C
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics*; D004283:Dog Diseases / Q000473:pathology / Q000821:virology*; D004285:Dogs; D005260:Female; D052691:Lambdapapillomavirus / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D018308:Papilloma, Inverted / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000473:pathology / Q000662:veterinary / Q000821:virology; D016415:Sequence Alignment; D012867:Skin / Q000473:pathology / Q000821:virology; D012878:Skin Neoplasms / Q000473:pathology / Q000662:veterinary* / Q000821:virology
D004279:DNA, Viral