title: The association between eNOS intron 4 VNTR polymorphism and delayed graft function of kidney allografts.
abstract: Nitric oxide (NO) is a multifunctional agent which serves as a key signaling molecule in physiological processes such as host defense, neuronal communication, and the regulation of vascular tone. Different polymorphic variations have been identified in the human NOS3 (eNOS) gene.The aim of the present study was to examine the association between polymorphisms of the NOS3 gene (G894T substitution within exon 7 and intron 4 VNTR polymorphism) and the development of delayed graft function as well as acute and chronic rejection.One hundred eighty-seven recipients of first renal transplants were included in the study. There were no significant associations between these polymorphisms and acute and chronic kidney allograft rejection. The intron 4 polymorphism was associated with delayed graft function after transplantation. The results of this study suggest that patients with the a allele of the eNOS intron 4 VNTR polymorphism may be predisposed to delayed graft function.
authors.affiliation: Department of Nephrology, Transplantology, and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Dutkiewicz
authors.forename: Leszek
authors.initials: L
authors.lastname: Domanski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Binczak-Kuleta
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pawlik
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Safranow
authors.forename: Andrzej
authors.initials: A
authors.lastname: Ciechanowicz
authors.forename: Violetta
authors.initials: V
authors.lastname: Dziedziejko
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Ciechanowski
mesh_terms: D000328:Adult; D000483:Alleles; D051799:Delayed Graft Function / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D012189:Retrospective Studies; D014184:Transplantation, Homologous
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III