[Steroidogenesis-related proteins expression in skin cells].
Peripheral benzodiazepine receptor (PBR, TsPO) is an outer mitochondrial membrane protein which is implicated in steroid biosynthesis regulation, apoptosis and cell proliferation. Immunocytochemical assay revealed decreased levels of PBR, its endogenous ligand DBI and cytochrome P450scc in malignant skin cells in comparison to normal keratinocytes and melanocytes. These data indicate diminished steroidogenesis in skin cancer.
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D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D002786:Cholesterol Side-Chain Cleavage Enzyme / Q000378:metabolism*; D012739:Gonadal Steroid Hormones / Q000096:biosynthesis*; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D008544:Melanocytes / Q000378:metabolism; D018079:Receptors, GABA / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism
D012739:Gonadal Steroid Hormones; D018079:Receptors, GABA; C499229:TSPO protein, human; D002786:Cholesterol Side-Chain Cleavage Enzyme