title: Diverse functions of perineuronal nets.
abstract: Perineuronal nets represent well-organised components of the extracellular matrix, which are surrounding cell bodies, dendrites, and axon segments of a particular class of neurones as well as forming lattice-like structures. The role of perineuronal nets is not fully elucidated yet. Perineuronal nets may play a beneficial role by stabilizing the extracellular milieu assuring the characteristic features of enveloped neurons and protecting them from the influence of harmful agents. On the other hand, perineuronal nets create a barrier which limits neuronal plasticity and counteracts regeneration. This review examines recent evidence concerning the significance of the occurrence of perineuronal nets.
authors.affiliation: Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Karetko
authors.forename: Jolanta
authors.initials: J
authors.lastname: Skangiel-Kramska
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism / Q000648:ultrastructure; D051379:Mice; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D010525:Peripheral Nerves / Q000166:cytology / Q000502:physiology*; D051381:Rats
chemical_list: D009419:Nerve Tissue Proteins