title: [Assessment of chemoradiation therapy for advanced rectal cancer invaded the pelvic organ].
abstract: We assess the effect of chemoradiation therapy for four cases of advanced rectal cancer. The radiation therapy consisted of 40-50 Gy delivered in fraction of 2 Gy/day. A treatment of 5-fluorouracil (500 mg/body) with l-leucovorin (100 mg/body) intravenously once a week, or oral S-1 (100 mg/day/body) for four weeks, was given during radiation therapy. Efficacy for primary carcinoma was evaluated as partial response in all four cases. We performed a curative operation in two cases. Histological efficacy for primary tumors was diagnosed as Grade 2 and Grade 3. Grade 3 adverse effect for neutropenia occurred in one patient, and Grade 3 adverse effect for appetite loss occurred in 2 patients. All cases survived without a recurrence for a period of 4 months-5 years and 3 months. Chemoradiation therapy was safe and an effective treatment prior to curative operation for advanced rectal cancer which invaded the pelvic organ.
authors.affiliation: Department of Surgery, Miyazaki Prefectural Hospital.
authors.forename: Koichi
authors.initials: K
authors.lastname: Doi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ogata
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hirano
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kudo
authors.forename: Tetsufumi
authors.initials: T
authors.lastname: Ochi
authors.forename: Akira
authors.initials: A
authors.lastname: Ishihara
authors.forename: Kazuma
authors.initials: K
authors.lastname: Kojima
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000628:therapy; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004338:Drug Combinations; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage; D010388:Pelvis / Q000473:pathology; D012004:Rectal Neoplasms / Q000473:pathology / Q000628:therapy*; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D005472:Fluorouracil