Renal disease in AIDS: it is not always HIVAN.
Human immunodeficiency virus (HIV) infection can cause a broad spectrum of clinical manifestations, ranging from an asymptomatic carrier state to severe immunodeficiency. The most common renal lesion, HIV-associated nephropathy (HIVAN), is a sclerosing glomerulopathy. However, potentially reversible causes of renal disease in HIV-infected patients should also be considered. We describe two cases of patients with acquired immune-deficiency syndrome (AIDS) who presented with rapidly progressive renal failure but were found to have reversible etiologies. The first case was found to have syphilis and the second, disseminated histoplasmosis; their renal injury resolved after initiation of a third-generation cephalosporin antibiotic and amphotericin B, respectively.
Bani-Hani
Samer
S
Division of Nephrology, Department of Medicine, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA. sbanihan@utmem.edu
Patel
Vikul
V
Larsen
Christopher P
CP
Walker
Patrick D
PD
Cooke
C Robert
CR
Showkat
Arif
A
D016263:AIDS-Associated Nephropathy / Q000209:etiology* / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D001706:Biopsy; D002443:Ceftriaxone / Q000627:therapeutic use; D006660:Histoplasmosis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D009494:Neurosyphilis / Q000150:complications* / Q000188:drug therapy
D002443:Ceftriaxone; D000666:Amphotericin B