[Preoperative chemotherapy for long-term results of small cell lung cancer].
OBJECTIVE
To reveal the pre-operative chemotherapy for long-term of small cell lung cancer.


METHODS
From January 1994 to January 2005, 263 patients with small cell lung cancer underwent combined therapy. The comparison of long-term survival rates was made between pre-operative chemotherapy group (n = 111) (group A) and post-operative chemotherapy (n = 96) (group B).


RESULTS
The analyses disclosed that the overall 5-year survival rate was 42.16%. The 5-year survival rate of group A was 38.25% while in group B it was 46.57%. 5-year survival rate of group A for N0-1 and N2 was 40.12% and 39.22%, that for stage I, II, IIIa, IIIb, IV was 60.15%, 35.70%, 40.16%, 14.29% and 0 respectively. 5-year survival rate of group B for N0-1 and N2 was 51.91% and 42.69%, that for stage I, II, IIIa, IIIb, IV was 61.1%, 50.23%, 42.32%, 26.47% and 0 respectively.


CONCLUSIONS
The comparison of the survival rate between patients with the pre-operative chemotherapy and those with chemotherapy post-operatively revealed trend of variation. Operation plus post-operative chemotherapy mode is indispensable for better prognosis of small cell lung cancer.
Duan
Yong
Y
Beijing Research Institute of Tuberculosis and Thoracic Tumors, Beijing Chest Hospital, Chest Surgery Department, Beijing 101149, China.
Bai
Lian-Qi
LQ
Gong
Chang-Fan
CF
Yan
Dong-Jie
DJ
Dou
Xue-Jun
XJ
D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011292:Premedication; D011300:Preoperative Care; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy* / Q000401:mortality* / Q000473:pathology; D015996:Survival Rate; D055815:Young Adult