Serologic investigations in children with inflammatory bowel disease and food allergy.
The aim of the study was the evaluation of frequency and titre of IgA ASCA and IgG ASCA and p-ANCA, c-ANCA in children with IBD and occurrence of ASCA antibodies in relation to coexistence of FA. Patients and methods. The study comprised 95 children at the ages of 2 to 18 years. The diagnosis of IBD was established on the basis of Porto criteria. Tests of blood serum were performed in all children: IgA and IgG ASCA, p-ANCA, c-ANCA using ELISA method. Results. IgE-dependent FA was found in 32.5% children with UC and in 21% with CD. We did not observe any relation between the occurrence of FA and the frequency and ASCA titre. p-ANCA were significantly more frequent in the group of children with UC. The occurrence of ASCA antibodies was observed in 73.7% of children with CD, 17.5% with UC and almost 30% with allergic colitis. Conclusions. Patients with CD and the presence of ASCA revealed a significantly more frequent localization of lesions within the small bowel and a tendency towards older age. We observed a connection between the occurrence of antibodies and the examined mutations of gene NOD2/CARD15.
Grzybowska-Chlebowczyk
Urszula
U
Gastroenterology Division, Department of Paediatrics, Medical University of Silesia, 40-752 Katowice, Poland.
Woś
Halina
H
Sieroń
Aleksander L
AL
Wiecek
Sabina
S
Auguściak-Duma
Aleksandra
A
Koryciak-Komarska
Halina
H
Kasznia-Kocot
Joanna
J
D000293:Adolescent; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003424:Crohn Disease / Q000097:blood / Q000235:genetics; D005512:Food Hypersensitivity / Q000097:blood*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D015212:Inflammatory Bowel Diseases / Q000097:blood*; D009154:Mutation
D019268:Antibodies, Antineutrophil Cytoplasmic; D007070:Immunoglobulin A; D007074:Immunoglobulin G