title: Tissue engineering in endodontics.
abstract: Tissue engineering is the science of design and manufacture of new tissues to replace impaired or damaged ones. The key ingredients for tissue engineering are stem cells, the morphogens or growth factors that regulate their differentiation, and a scaffold of extracellular matrix that constitutes the microenvironment for their growth. Recently, there has been increasing interest in applying the concept of tissue engineering to endodontics. The aim of this study was to review the body of knowledge related to dental pulp stem cells, the most common growth factors, and the scaffolds used to control their differentiation, and a clinical technique for the management of immature non-vital teeth based on this novel concept.
authors.affiliation: Department of Endodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt. Shehab007@yahoo.com
authors.forename: Shehab El-Din M
authors.initials: SE
authors.lastname: Saber
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D003771:Dental Papilla / Q000166:cytology; D003782:Dental Pulp / Q000166:cytology; D003790:Dental Pulp Necrosis / Q000628:therapy*; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D039902:Multipotent Stem Cells / Q000166:cytology; D018919:Neovascularization, Physiologic; D010513:Periodontal Ligament / Q000166:cytology; D012038:Regeneration; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014094:Tooth, Deciduous / Q000166:cytology
chemical_list: D006133:Growth Substances