[Evaluation of hepatic arterial infusion chemotherapy for liver metastasis from gastric cancer].
We performed hepatic arterial infusion (HAI) chemotherapy for 11 patients with liver metastasis from gastric cancer, who had no other metastasis. The main antineoplastic drug was 5-fluorouracil (5-FU). The catheter was inserted into the hepatic artery using the GDA coiling method by interventional radiologic technique in 9 patients, and by operative treatment in 2 patients. The response rate for 10 patients was 91% (CR 3, PR 7, PD 1). The survival time from the beginning of the HAI chemotherapy was 8-34 months. The causes of withdrawal from the chemotherapy were PD in 7 patients and catheter troubles in 4 patients. There was no patient suffering from severe adverse effect. The HAI chemotherapy was effective and useful for patients with liver metastasis of gastric cancer. We thought a gastric cancer patient with liver metastasis who didn't have an uncontrollable other organ metastasis was a good target for this regimen.
Ota
Takumi
T
Department of Frontier Surgery, Graduate School of Medicine, Chiba University.
Shuto
Kiyohiko
K
Ohira
Gaku
G
Natsume
Toshiyuki
T
Saito
Hiroshige
H
Sato
Asami
A
Kawahira
Hiroshi
H
Nabeya
Yoshihiro
Y
Matsubara
Hisahiro
H
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000473:pathology*
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil