Biochemical characteristics and risk factors in non-alcoholic fatty liver.
Non-alcoholic fatty liver disease (NAFLD) is a condition associated with metabolic disturbances. The aim of the present study was to investigate the biochemical characteristics and risk factors for NAFLD. The study was carried out in a total of 881 subjects diagnosed by ultrasonography. NAFLD occurred mainly in middle-aged individuals, with a prevalence of 63.1 per cent. Multiple logistic regression analysis showed that male gender, presence of obesity, hypertension, dyslipidemia, or Type 2 diabetes and elevated serum alanine transaminase activities were independent risk factors for the development of NAFLD. Subjects with NAFLD were obese, hypertensive and often had signs of disturbances in lipid and glucose metabolism and abnormalities in hepatic functions. These findings show risk factors in the development and offer opportunities for prevention of NAFLD.
Wang
Ying
Y
Department of Clinical Biochemistry, Chinese PLA General Hospital, No 28, Fuxing Road, Beijing, China.
Dong
Jin
J
Liu
Hong-ying
HY
Wang
De-qing
DQ
Tian
Ya-ping
YP
D000410:Alanine Transaminase / Q000097:blood; D000704:Analysis of Variance; D001219:Aspartate Aminotransferases / Q000097:blood; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D050171:Dyslipidemias / Q000150:complications; D005234:Fatty Liver / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology* / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D016015:Logistic Models; D008297:Male; D009765:Obesity / Q000150:complications; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D014463:Ultrasonography; D005723:gamma-Glutamyltransferase / Q000097:blood
D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005947:Glucose