title: Comparison of methods for statistical analysis of combination studies.
abstract: This paper is concerned with the statistical analysis of data obtained in studies of the joint action of drugs. The three methods that are compared are illustrated on real data (1), using the statistical package SAS. It is argued that while the results obtained using these methods do not differ substantially, the method allowing for estimating simultaneously all required parameters is to be preferred. It allows for a statistical test for the significance of the joint action of the drug combinations to be carried out.
authors.affiliation: School of Mathematics, University of Manchester, UK. a.n.donev@manchester.ac.uk
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Donev
mesh_terms: D045744:Cell Line, Tumor; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004347:Drug Interactions; D004357:Drug Synergism; D005492:Folic Acid; D005971:Glutamates; D006801:Humans; D008962:Models, Theoretical; D011743:Pyrimidines; D016597:Trimetrexate
chemical_list: D004338:Drug Combinations; D005971:Glutamates; D011743:Pyrimidines; D005492:Folic Acid; C105066:AG 2034; D016597:Trimetrexate