title: Synthesis, crystal structure, characterization of zinc(II), cadmium(II) complexes with 3-thiophene aldehyde thiosemicarbazone (3TTSCH). Biological activities of 3TTSCH and its complexes.
abstract: The reaction of zinc(II) chloride, cadmium(II) chloride and bromide with 3-thiophene aldehyde thiosemicarbazone leads to the formation of a series of new complexes. They have been characterized by spectroscopic studies: infrared, (1)H NMR, and electronic spectra. The crystal structures of the compound [ZnCl(2)(3TTSCH)(2)] and [CdBr(2)(3TTSCH)(2)] have been determined by X-ray diffraction methods. For the complexes [ZnCl(2)(3TTSCH)(2)] and [CdBr(2)(3TTSCH)(2)], the central ion is coordinated through the sulfur, and for the complexes [CdCl(2)(3TTSCH)], [CdBr(2)(3TTSCH)] the ion is coordinated through the sulfur as well as azomethine nitrogen atom of the thiosemicarbazone. In addition, fungistatic and bacteriostatic activities of both ligand and complexes have been evaluated. Cadmium(II) complexes have shown the most significant activities.
authors.affiliation: Laboratoire SONAS, EA 921, IFR QUASAV 149, Université d'Angers, UFR Sciences Pharmaceutiques et Ingénierie de la Santé, 16 Boulevard Daviers, 49045 Angers cedex 01, France.
authors.forename: Kusaï
authors.initials: K
authors.lastname: Alomar
authors.forename: Anne
authors.initials: A
authors.lastname: Landreau
authors.forename: Marie
authors.initials: M
authors.lastname: Kempf
authors.forename: Mustayeen A
authors.initials: MA
authors.lastname: Khan
authors.forename: Magali
authors.initials: M
authors.lastname: Allain
authors.forename: Gilles
authors.initials: G
authors.lastname: Bouet
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D002104:Cadmium / Q000737:chemistry*; D002175:Candida / Q000187:drug effects; D018360:Crystallography, X-Ray; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D013882:Thiosemicarbazones; D002104:Cadmium; D015032:Zinc