title: Gender differences in platelet aggregation in healthy individuals.
abstract: This study evaluated gender variability in platelet aggregation in response to common agonists. Platelet aggregation was measured in 36 healthy men and women free of any antiplatelet medication, aged 22-36 years, of Caucasian (White not of Hispanic origin), Hispanic, and African-American not of Hispanic origin. In this ex-vivo study, we investigated platelet aggregation in response to adenosine-5'-diphosphate (ADP), epinephrine (EPI), arachidonic acid (AA) and collagen (COL), using a platelet ionized calcium aggregometer (Chrono-Log Co.). Platelet aggregation response to all tested agonists was higher in females than in males regardless of ethnicity. The most significant differences were observed with collagen (P < 0.01). Among the ethnic groups, Caucasian women were most prone to platelet aggregation. Gender is a determinant of agonist effects on platelet aggregability in healthy subjects.
authors.affiliation: Department of Internal Medicine, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Otahbachi
authors.forename: Jan
authors.initials: J
authors.lastname: Simoni
authors.forename: Grace
authors.initials: G
authors.lastname: Simoni
authors.forename: John F
authors.initials: JF
authors.lastname: Moeller
authors.forename: Cihan
authors.initials: C
authors.lastname: Cevik
authors.forename: Gary E
authors.initials: GE
authors.lastname: Meyerrose
authors.forename: Chanwit
authors.initials: C
authors.lastname: Roongsritong
mesh_terms: D000244:Adenosine Diphosphate; D000328:Adult; D001741:Black or African American; D016718:Arachidonic Acid; D003094:Collagen; D004837:Epinephrine; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D010974:Platelet Aggregation; D010979:Platelet Function Tests; D012016:Reference Values; D012737:Sex Factors; D013781:Texas; D044465:White People; D055815:Young Adult
chemical_list: D016718:Arachidonic Acid; D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine