title: The effectiveness of nasal decongestants, oral decongestants and oral decongestant-antihistamines in the treatment of acute otitis media in children.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effectiveness of nasal decongestants, oral decongestants and oral decongestant-antihistamines in the treatment of acute otitis media and resolution of the middle ear effusion in children.
  
  
  METHODS
  355 ears of 318 children [160 boys (179 ears) and 158 girls (176 ears)] who were diagnosed to have acute otitis media and treated for it with different drug regimens were evaluated retrospectively regarding resolution of the middle ear fluid. 151 ears were treated with antibiotics and analgesics (group 1), 64 with antibiotics, topical decongestants and analgesics (group 2), 81 with antibiotics, oral decongestants and analgesics (group 3), and 59 with antibiotics, oral decongestant-antihistamine combinations and analgesics (group 4). The children with middle ear effusion were followed up for three months.
  
  
  RESULTS
  Group 1, 2, 3 and 4 had persistent middle ear effusion and the presence of middle ear effusion was 27.2%, 18.8%, 25.9%, 28.8% at the 1st month and 5.8%, 0%, 0% and 5.9% at the end of the 3rd month, respectively. At the end of the 3rd month, there was no significant difference between the groups regarding the resolution rates of the middle ear fluids in the antibiotic group and decongestants groups (p>0.05).
  
  
  CONCLUSIONS
  We do not recommend the use of decongestants and antihistamines in the treatment of acute otitis media as they do not change the natural course of the disease.
authors.affiliation: Department of Otolaryngology, Medicine Faculty of Gaziosmanpaşa University, Tokat, Turkey. aeyibilen@yahoo.com
authors.forename: Ahmet
authors.initials: A
authors.lastname: Eyibilen
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Aladağ
authors.forename: Mehmet
authors.initials: M
authors.lastname: Güven
authors.forename: Sema
authors.initials: S
authors.lastname: Koç
authors.forename: Levent
authors.initials: L
authors.lastname: Gürbüzler
mesh_terms: D000158:Acoustic Impedance Tests; D000208:Acute Disease; D000281:Administration, Intranasal; D000284:Administration, Oral; D000293:Adolescent; D000700:Analgesics / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006633:Histamine Antagonists / Q000592:standards / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D014663:Nasal Decongestants / Q000592:standards / Q000627:therapeutic use*; D010034:Otitis Media with Effusion / Q000188:drug therapy*; D038781:Otoscopy; D012189:Retrospective Studies; D012737:Sex Factors; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D000900:Anti-Bacterial Agents; D006633:Histamine Antagonists; D014663:Nasal Decongestants