title: Diminished selenium levels in hemodialysis and continuous ambulatory peritoneal dialysis patients.
abstract: In this cross-sectional study, selenium (Se) levels in the sera of 35 hemodialysis (HD) patients and 34 patients undergoing continuous ambulatory peritoneal dialysis (CAPD) for more than 3 months were compared with the serum Se levels of 34 healthy volunteers. The observed Se levels of 100.8 ± 51.9 µg/L in the sera of the HD patients and of 65.5 ± 32.1 µg/L in the sera of the CAPD patients were significantly lower than the 134.9 ± 81.2 µg/L of the controls, with p = 0.002 and 0.02, respectively. Furthermore, the Se levels were significantly higher in the HD rather than the CAPD patients (p = 0.01). In the spent dialysate effluent fluid of 32 of the CAPD patients Se was undetectable, in the remaining two CAPD patients the Se levels were 1.9 and 4.6μg/l, respectively. The low Se levels of HD and CAPD patients as compared to healthy persons are attributed to diminished Se retention due to chronic oxidative stress.
authors.affiliation: Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Pakfetrat
authors.forename: Leila
authors.initials: L
authors.lastname: Malekmakan
authors.forename: Mahshid
authors.initials: M
authors.lastname: Hasheminasab
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010531:Peritoneal Dialysis, Continuous Ambulatory; D012643:Selenium / Q000097:blood*; D013997:Time Factors
chemical_list: D012643:Selenium