Synthesis of chiral aminophosphines from chiral aminoalcohols via cyclic sulfamidates.
Protic aminophosphines with multiple chiral centers were synthesized in good yields and high purity by the nucleophilic ring-opening of N-protected cyclic sulfamidates with metal phosphides, followed by hydrolysis and deprotection. This synthetic approach is clean, scalable, and high yielding. The method provides an efficient alternative route for the synthesis of chiral aminophosphines.
Guo
Rongwei
R
Kanata Chemical Technologies Inc., 101 College Street, Office 230, MaRS Center, South Tower, Toronto, ON, Canada, M5G 1L7. rongwei@kctchem.com
Lu
Shuiming
S
Chen
Xuanhua
X
Tsang
Chi-Wing
CW
Jia
Wenli
W
Sui-Seng
Christine
C
Amoroso
Dino
D
Abdur-Rashid
Kamaluddin
K