Midregional pro-A-type natriuretic peptide for the evaluation of exercise intolerance.
The aim of this study was to determine the accuracy of midregional pro-A-type natriuretic peptide (MR-proANP) for the identification of a cardiocirculatory exercise limitation (CL) as assessed by cardiopulmonary exercise testing (CPET) and to compare it to B-type natriuretic peptide (BNP). Among 94 patients with CPET data fulfilling criteria for appropriate effort and sufficient diagnostic certainty, 27 (29%) had CL. The areas under the receiver-operator-characteristic curve for MR-proANP and BNP to identify CL were 0.84 and 0.79 respectively (p=0.17). In conclusion, MR-proANP had a comparable accuracy to BNP for the identification of CL and might be a valuable assistance for the differentiation of exercise intolerance.
Maeder
Micha T
MT
Baker IDI Heart and Diabetes Institute, Melbourne, Australia. Electronic address: micha.maeder@bluewin.ch.
Brutsche
Martin H
MH
Division of Respiratory Medicine, Kantonsspital St. Gallen, Switzerland.
Christ
Andreas
A
Department of Internal Medicine, University Hospital Basel, Switzerland.
Staub
Daniel
D
Department of Internal Medicine, University Hospital Basel, Switzerland.
Noveanu
Markus
M
Department of Internal Medicine, University Hospital Basel, Switzerland.
Breidthardt
Tobias
T
Department of Internal Medicine, University Hospital Basel, Switzerland.
Schaub
Nora
N
Department of Internal Medicine, University Hospital Basel, Switzerland.
Potocki
Mihael
M
Department of Internal Medicine, University Hospital Basel, Switzerland.
Reichlin
Tobias
T
Department of Internal Medicine, University Hospital Basel, Switzerland.
Morgenthaler
Nils G
NG
Department of Research, B.R.A.H.M.S. AG, Biotechnology Center, Henningsdorf/Berlin, Germany.
Bergmann
Andreas
A
Department of Research, B.R.A.H.M.S. AG, Biotechnology Center, Henningsdorf/Berlin, Germany.
Mueller
Christian
C
Department of Internal Medicine, University Hospital Basel, Switzerland.
D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005080:Exercise Test / Q000592:standards*; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood
D015415:Biomarkers; C552580:midregional pro-atrial natriuretic peptide, human; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor