High-density lipoprotein affects antigen presentation by interfering with lipid raft: a promising anti-atherogenic strategy.
Atherosclerosis is a chronic inflammatory disease. Immunomodulation of atherosclerosis emerges as a promising approach to prevention and treatment of this widely prevalent disease. The function of high-density lipoprotein (HDL) to promote reverse cholesterol transport may explain the ability of its protection against atherosclerosis. Findings that HDL and apolipoprotein A-I (apoA-I) inhibited the ability of antigen presenting cells (APCs) to stimulate T cells might be attributed to lipid raft, a cholesterol-rich microdomain exhibiting functional properties depending largely upon its lipid composition. Thus, modulating cholesterol in lipid raft may provide a promising anti-atherogenic strategy.
Wang
S-H
SH
Department of Cardiology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yuan
S-G
SG
Peng
D-Q
DQ
Zhao
S-P
SP
D000818:Animals; D017951:Antigen Presentation / Q000187:drug effects* / Q000502:physiology; D016632:Apolipoprotein A-I / Q000502:physiology; D050197:Atherosclerosis / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D001692:Biological Transport / Q000187:drug effects; D002784:Cholesterol / Q000502:physiology; D004195:Disease Models, Animal; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy; D008075:Lipoproteins, HDL / Q000494:pharmacology / Q000502:physiology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008563:Membrane Lipids / Q000502:physiology; D021962:Membrane Microdomains / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D016632:Apolipoprotein A-I; D000949:Histocompatibility Antigens Class II; D008075:Lipoproteins, HDL; D008563:Membrane Lipids; D002784:Cholesterol