title: Implementation of a shared data repository and common data dictionary for fetal alcohol spectrum disorders research.
abstract: Many previous attempts by fetal alcohol spectrum disorders researchers to compare data across multiple prospective and retrospective human studies have failed because of both structural differences in the collected data and difficulty in coming to agreement on the precise meaning of the terminology used to describe the collected data. Although some groups of researchers have an established track record of successfully integrating data, attempts to integrate data more broadly among different groups of researchers have generally faltered. Lack of tools to help researchers share and integrate data has also hampered data analysis. This situation has delayed improving diagnosis, intervention, and treatment before and after birth. We worked with various researchers and research programs in the Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CI-FASD) to develop a set of common data dictionaries to describe the data to be collected, including definitions of terms and specification of allowable values. The resulting data dictionaries were the basis for creating a central data repository (CI-FASD Central Repository) and software tools to input and query data. Data entry restrictions ensure that only data that conform to the data dictionaries reach the CI-FASD Central Repository. The result is an effective system for centralized and unified management of the data collected and analyzed by the initiative, including a secure, long-term data repository. CI-FASD researchers are able to integrate and analyze data of different types, using multiple methods, and collected from multiple populations, and data are retained for future reuse in a secure, robust repository.
authors.affiliation: University Information Technology Services, Indiana University, 535 W. Michigan St., Indianapolis, IN 46202, USA. aarenson@iupui.edu
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Arenson
authors.forename: Ludmila N
authors.initials: LN
authors.lastname: Bakhireva
authors.forename: Christina D
authors.initials: CD
authors.lastname: Chambers
authors.forename: Christina A
authors.initials: CA
authors.lastname: Deximo
authors.forename: Tatiana
authors.initials: T
authors.lastname: Foroud
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Jacobson
authors.forename: Sandra W
authors.initials: SW
authors.lastname: Jacobson
authors.forename: Kenneth Lyons
authors.initials: KL
authors.lastname: Jones
authors.forename: Sarah N
authors.initials: SN
authors.lastname: Mattson
authors.forename: Philip A
authors.initials: PA
authors.lastname: May
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Moore
authors.forename: Kimberly
authors.initials: K
authors.lastname: Ogle
authors.forename: Edward P
authors.initials: EP
authors.lastname: Riley
authors.forename: Luther K
authors.initials: LK
authors.lastname: Robinson
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Rogers
authors.forename: Ann P
authors.initials: AP
authors.lastname: Streissguth
authors.forename: Michel C
authors.initials: MC
authors.lastname: Tavares
authors.forename: Joseph
authors.initials: J
authors.lastname: Urbanski
authors.forename: Yelena
authors.initials: Y
authors.lastname: Yezerets
authors.forename: Radha
authors.initials: R
authors.lastname: Surya
authors.forename: Craig A
authors.initials: CA
authors.lastname: Stewart
authors.forename: William K
authors.initials: WK
authors.lastname: Barnett
mesh_terms: D000428:Alcohol Drinking; D035843:Biomedical Research; D019465:Craniofacial Abnormalities; D003625:Data Collection; D019992:Databases as Topic / Q000458:organization & administration; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy; D006801:Humans; D009483:Neuropsychological Tests; D011247:Pregnancy; D011446:Prospective Studies; D012189:Retrospective Studies; D012984:Software; D011795:Surveys and Questionnaires