title: Cooperative effect of serum 25-hydroxyvitamin D concentration and a polymorphism of transforming growth factor-beta1 gene on the prevalence of vertebral fractures in postmenopausal osteoporosis.
abstract: A T869-->C polymorphism of the transforming growth factor-beta1 (TGF-beta1) gene is reported to be associated with genetic susceptibility to both osteoporosis and vertebral fractures. A low serum 25-hydroxyvitamin D [25(OH)D] level is known to be associated with a higher risk for hip fracture. This study aimed to assess a possible cooperative effect of the gene polymorphism and vitamin D status on vertebral fracture risk. The prevalence of vertebral fracture in 168 postmenopausal female patients with osteoporosis was analyzed, and its association with the TGF-beta1 gene polymorphism and serum 25(OH)D concentration was assessed cross-sectionally. The fracture prevalence increased according to the rank order of the TGF-beta1 genotypes CC < CT < TT, as expected. A significant difference was found not only between the CC and TT genotypes (P = 0.005) but also between the CC and CT genotypes (P < 0.05) when the patients with serum 25(OH)D of more than the median value [22 ng/ml (55 nmol/l)] were analyzed. On the other hand, when those with serum 25(OH)D of less than the median value were analyzed, the protective effect of the C allele against the fracture was blunted; statistical significance in the difference of the fracture prevalence was lost between the CC genotype and the other genotypes. These data suggest that vitamin D fulfillment is prerequisite for the TGF-beta1 genotype in exerting its full effect on the fracture prevalence.
authors.affiliation: Department of Internal Medicine, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan. seimori1106@gmail.com
authors.forename: Seijiro
authors.initials: S
authors.lastname: Mori
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Fuku
authors.forename: Yuko
authors.initials: Y
authors.lastname: Chiba
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Tokimura
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hosoi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kimbara
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Tamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Araki
authors.forename: Masashi
authors.initials: M
authors.lastname: Tanaka
authors.forename: Hideki
authors.initials: H
authors.lastname: Ito
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005838:Genotype; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D016103:Spinal Fractures / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D053773:Transforming Growth Factor beta1; D014807:Vitamin D; C104450:25-hydroxyvitamin D