title: Comparison of diagnostic quality and accuracy in color-coded versus gray-scale DCE-MR imaging display.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the diagnostic value and tumor-vascular display properties (microcirculation) of two different functional MRI post-processing and display (color and gray-scale display) techniques used in oncology.
  
  
  METHODS
  The study protocol was approved by the IRB and written informed consent was obtained from all patients. 38 dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) data sets of patients with malignant pleural-mesothelioma were acquired and post-processed. DCE-MRI was performed at 1.5 tesla with a T1-weighted 2D gradient-echo-sequence (TR 7.0 ms, TE 3.9 ms, 15 axial slices, 22 sequential repetitions), prior and during chemotherapy. Subtracting first image of contrast-enhanced-dynamic series from the last, produced gray-scale images. Color images were produced using a pharmacokinetic two-compartment model. Eight raters, blinded to diagnosis, by visual assessment of post-processed images evaluated both diagnostic quality of the images and vasculature of the tumor using a rating scale ranging from -5 to +5. The scores for vasculature were assessed by correlating with the maximum amplitude of the total-tumor-ROI for accuracy.
  
  
  RESULTS
  Color coded images were rated as significantly higher in diagnostic quality and tumor vascular score than gray-scale images (p < 0.001, 0.005). ROI signal amplitude analysis and vascular ratings on color coded images were better correlated compared to gray-scale images rating (p < 0.05).
  
  
  CONCLUSIONS
  Color coded images were shown to have higher diagnostic quality and accuracy with respect to tumor vasculature in DCE-MRI, therefore their implementation in clinical assessment and follow-up should be considered for wider application.
authors.affiliation: Department of Radiology E 010, German Cancer Research Center (DKFZ), INF 280, 69120, Heidelberg, Germany. dramit.mehndiratta@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Mehndiratta
authors.forename: M V
authors.initials: MV
authors.lastname: Knopp
authors.forename: C M
authors.initials: CM
authors.lastname: Zechmann
authors.forename: M
authors.initials: M
authors.lastname: Owsijewitsch
authors.forename: H
authors.initials: H
authors.lastname: von Tengg-Kobligk
authors.forename: P
authors.initials: P
authors.lastname: Zamecnik
authors.forename: H U
authors.initials: HU
authors.lastname: Kauczor
authors.forename: P L
authors.initials: PL
authors.lastname: Choyke
authors.forename: F L
authors.initials: FL
authors.lastname: Giesel
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003287:Contrast Media; D003936:Diagnosis, Computer-Assisted; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis* / Q000628:therapy; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000628:therapy; D011237:Predictive Value of Tests; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA