Detection of KPC in Acinetobacter spp. in Puerto Rico.
During an island-wide PCR-based surveillance study of beta-lactam resistance in multidrug-resistant (MDR) Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter calcoaceticus-baumannii complex isolates obtained from 17 different hospitals, 10 KPC-positive Acinetobacter isolates were identified. DNA sequencing of the bla(KPC) gene identified KPC-2, -3, and -4 and a novel variant, KPC-10. This is the first report of a KPC-type beta-lactamase identified in Acinetobacter species.
Robledo
Iraida E
IE
University of Puerto Rico, School of Medicine, Department of Microbiology and Medical Zoology, San Juan, Puerto Rico.
Aquino
Edna E
EE
Santé
María I
MI
Santana
Jorge L
JL
Otero
Diana M
DM
León
Carlos F
CF
Vázquez
Guillermo J
GJ
D000150:Acinetobacter / Q000145:classification* / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods; D011647:Puerto Rico / Q000453:epidemiology; D018440:beta-Lactam Resistance / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
C491478:beta-lactamase KPC-2; D001618:beta-Lactamases