title: Bactericidal activity of telavancin, vancomycin and metronidazole against Clostridium difficile.
abstract: We compared the time-kill activities of telavancin, vancomycin and metronidazole at concentrations of 2 times, 4 times, and 8 times their respective MICs against five Clostridium difficile strains including REA type BI, using inocula that contained predominantly either vegetative cells or spores. Telavancin MICs (0.125-0.25 microg/ml) were 2-8-fold lower than those of vancomycin. Telavancin was bacteriostatic, reducing the inoculum by 1-2.5 log(10) after 24 h. No major differences occurred with the different inoculum forms or the REA types. Although telavancin MICs were 2-8 times lower than vancomycin, both demonstrated similar bacteriostatic activity against C. difficile while metronidazole was bactericidal.
authors.affiliation: R. M. Alden Research Laboratory, Culver City, CA 90230, USA. ejcgmd@aol.com
authors.forename: Ellie J C
authors.initials: EJ
authors.lastname: Goldstein
authors.forename: Diane M
authors.initials: DM
authors.lastname: Citron
authors.forename: Kerin L
authors.initials: KL
authors.lastname: Tyrrell
authors.forename: Yumi A
authors.initials: YA
authors.lastname: Warren
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000187:drug effects*; D006801:Humans; D000077427:Lipoglycopeptides; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D000091402:Prohibitins; D013997:Time Factors; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000077427:Lipoglycopeptides; C000717331:PHB2 protein, human; D000091402:Prohibitins; D008795:Metronidazole; D014640:Vancomycin; C487637:telavancin