title: Catalytic alkylation of methyl-N-heteroaromatics with alcohols.
abstract: A novel catalytic C-C coupling reaction in which N-heteroaromatic-substituted methyl groups are efficiently alkylated using primary alcohols is introduced. The synthesis protocol is based on iridium catalysts and most likely relies on the "borrowing hydrogen" or "hydrogen autotransfer" mechanism. A variety of substrate combinations can readily be employed in this reaction, including pyrimidines, pyrazines, pyridazines, and even fairly activated 2- and 4-picolines.
authors.affiliation: Anorganische Chemie II, Universität Bayreuth, 95440 Bayreuth, Germany.
authors.forename: Benoît
authors.initials: B
authors.lastname: Blank
authors.forename: Rhett
authors.initials: R
authors.lastname: Kempe
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000478:Alkylation; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D006571:Heterocyclic Compounds; D006841:Hydrocarbons, Aromatic; D009942:Organometallic Compounds; D007495:Iridium