title: Novel thermosensitive nano-micelles from triblock copolymer for drug delivery.
abstract: Novel thermosensitive nano-micelles, based on Poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA), as carriers for drug delivery were researched. The critical micelle concentration of the copolymer in aqueous solution was determined to be 2.34 microgram/ml by fluorescence spectroscopy using pyrene as a fluorescence probe. The lower critical solution temperature (LCST) of the copolymer was measured in distilled water by optical transmittance, and the LCST was varied from 35 to 55 degrees C depending on polymer concentration. Acetaminophen as a model drug was loaded in nano-micelles by solvent evaporation method. In vitro acetaminophen release from micelles showed a sustained modality compared with the free drug as a control, and an obviously high release rate when temperature was increased above LCST. The studies showed that nano-micelles made from PLGA-PEG-PLGA could be ideal candidate carriers for tumor-special drug delivery.
authors.affiliation: College of Bioengineering, Chongqing University, Chongqing, 400030, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Bochu
authors.initials: B
authors.lastname: Wang
authors.forename: Weili
authors.initials: W
authors.lastname: Qiao
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D003460:Crystallization / Q000379:methods*; D004337:Drug Carriers / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008823:Micelles; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D011098:Polyglactin 910 / Q000737:chemistry*; D013499:Surface Properties; D013696:Temperature
chemical_list: D004337:Drug Carriers; D046911:Macromolecular Substances; D008823:Micelles; C528571:poly(lactic-co-glycolic acid)-polyethylene glycol-poly(lactic-co-glycolic acid); D011098:Polyglactin 910; D011092:Polyethylene Glycols