title: Multimodal surface-based morphometry reveals diffuse cortical atrophy in traumatic brain injury.
abstract: BACKGROUND
  Patients with traumatic brain injury (TBI) often present with significant cognitive deficits without corresponding evidence of cortical damage on neuroradiological examinations. One explanation for this puzzling observation is that the diffuse cortical abnormalities that characterize TBI are difficult to detect with standard imaging procedures. Here we investigated a patient with severe TBI-related cognitive impairments whose scan was interpreted as normal by a board-certified radiologist in order to determine if quantitative neuroimaging could detect cortical abnormalities not evident with standard neuroimaging procedures.
  
  
  METHODS
  Cortical abnormalities were quantified using multimodal surfaced-based morphometry (MSBM) that statistically combined information from high-resolution structural MRI and diffusion tensor imaging (DTI). Normal values of cortical anatomy and cortical and pericortical DTI properties were quantified in a population of 43 healthy control subjects. Corresponding measures from the patient were obtained in two independent imaging sessions. These data were quantified using both the average values for each lobe and the measurements from each point on the cortical surface. The results were statistically analyzed as z-scores from the mean with a p < 0.05 criterion, corrected for multiple comparisons. False positive rates were verified by comparing the data from each control subject with the data from the remaining control population using identical statistical procedures.
  
  
  RESULTS
  The TBI patient showed significant regional abnormalities in cortical thickness, gray matter diffusivity and pericortical white matter integrity that replicated across imaging sessions. Consistent with the patient's impaired performance on neuropsychological tests of executive function, cortical abnormalities were most pronounced in the frontal lobes.
  
  
  CONCLUSIONS
  MSBM is a promising tool for detecting subtle cortical abnormalities with high sensitivity and selectivity. MSBM may be particularly useful in evaluating cortical structure in TBI and other neurological conditions that produce diffuse abnormalities in both cortical structure and tissue properties.
authors.affiliation: Veterans Affairs Northern California Health Care System, Martinez, CA, USA. andturken@ebire.org
authors.forename: And U
authors.initials: AU
authors.lastname: Turken
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Herron
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Kang
authors.forename: Larry E
authors.initials: LE
authors.lastname: O'Connor
authors.forename: Donna J
authors.initials: DJ
authors.lastname: Sorenson
authors.forename: Juliana V
authors.initials: JV
authors.lastname: Baldo
authors.forename: David L
authors.initials: DL
authors.lastname: Woods
mesh_terms: D000328:Adult; D000465:Algorithms; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology*; D001930:Brain Injuries / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique