The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics.
A major challenge in bacterial pathogenesis is understanding the molecular basis of the switch from saprophytism to virulence. Following a recent whole-genome transcriptomic analysis using tiling arrays, an article published in BMC Genomics reports the first use of RNA-seq in Listeria monocytogenes in order to identify genes controlled by sigma B, a transcriptional regulator with a critical role in virulence.
Cossart
Pascale
P
Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F-75015, France. pcossart@pasteur.fr
Archambaud
Cristel
C
D000907:Antibodies, Bacterial; D001483:Base Sequence; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D008089:Listeria monocytogenes / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity; D008088:Listeriosis / Q000235:genetics / Q000503:physiopathology*; D020411:Oligonucleotide Array Sequence Analysis; D014774:Virulence / Q000235:genetics*; D037521:Virulence Factors / Q000235:genetics* / Q000276:immunology
D000907:Antibodies, Bacterial; D037521:Virulence Factors