title: Acute promyelocytic leukemia treated with idarubicin complicated by focal segmental glomerulosclerosis.
abstract: The authors report a 9-year-old boy presenting with a left cerebral ischemic infarction as the first manifestation of acute promyelocytic leukemia. During consolidation chemotherapy, the patient developed nephrotic syndrome and a renal biopsy revealed focal segmental glomerulosclerosis (FSGS). Remission in bone marrow was achieved with chemotherapy, however, new intracranial ischemic areas developed on follow-up. Acute promyelocytic leukemia complicated by FSGS has not been previously reported in children. There may be a relationship between anthracycline treatment and FSGS. Thrombosis could be related with both leukemia and nephrotic syndrome, here thrombosis was the initial symptom, before FSGS was diagnosed.
authors.affiliation: Departments of Pediatrics, Pediatric Hematology-Oncology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Safa
authors.initials: S
authors.lastname: Bariş
authors.forename: Mine
authors.initials: M
authors.lastname: Ozdil
authors.forename: Nilüfer
authors.initials: N
authors.lastname: Topal
authors.forename: Omer
authors.initials: O
authors.lastname: Doğru
authors.forename: Nihal
authors.initials: N
authors.lastname: Ozdemir
authors.forename: Lale
authors.initials: L
authors.lastname: Sever
authors.forename: Sait
authors.initials: S
authors.lastname: Albayram
authors.forename: Işin
authors.initials: I
authors.lastname: Kiliçaslan
authors.forename: Tiraje
authors.initials: T
authors.lastname: Celkan
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D002648:Child; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology*; D006801:Humans; D015255:Idarubicin / Q000009:adverse effects*; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications / Q000188:drug therapy*; D008297:Male; D009404:Nephrotic Syndrome / Q000209:etiology; D013927:Thrombosis / Q000209:etiology
chemical_list: D000903:Antibiotics, Antineoplastic; D015255:Idarubicin