Recent advances in synthetic bioelastomers.
This article reviews the degradability of chemically synthesized bioelastomers, mainly designed for soft tissue repair. These bioelastomers involve biodegradable polyurethanes, polyphosphazenes, linear and crosslinked poly(ether/ester)s, poly(epsilon-caprolactone) copolymers, poly(1,3-trimethylene carbonate) and their copolymers, poly(polyol sebacate)s, poly(diol-citrates) and poly(ester amide)s. The in vitro and in vivo degradation mechanisms and impact factors influencing degradation behaviors are discussed. In addition, the molecular designs, synthesis methods, structure properties, mechanical properties, biocompatibility and potential applications of these bioelastomers were also presented.
Shi
Rui
R
Laboratory of Bone Tissue Engineering of Beijing Research Institute of Traumatology and Orthopaedics, Beijing 100035, China.
Chen
Dafu
D
Laboratory of Bone Tissue Engineering of Beijing Research Institute of Traumatology and Orthopaedics, Beijing 100035, China.
Liu
Quanyong
Q
Beijing Key Laboratory on Preparation and Processing of Novel Polymer Materials at Beijing University of Chemical Technology, 100029, China.
Wu
Yan
Y
Beijing Key Laboratory on Preparation and Processing of Novel Polymer Materials at Beijing University of Chemical Technology, 100029, China.
Xu
Xiaochuan
X
Department of Spine Surgery of Beijing JiShuiTan Hospital, the Fourth Clinical Medical College of Peking University, Beijing 100035, China.
Zhang
Liqun
L
Beijing Key Laboratory on Preparation and Processing of Novel Polymer Materials at Beijing University of Chemical Technology, 100029, China.
Tian
Wei
W
Laboratory of Bone Tissue Engineering of Beijing Research Institute of Traumatology and Orthopaedics, Beijing 100035, China.|Department of Spine Surgery of Beijing JiShuiTan Hospital, the Fourth Clinical Medical College of Peking University, Beijing 100035, China.
D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D054813:Polyhydroxyalkanoates / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D023822:Tissue Engineering
D001672:Biocompatible Materials; D009943:Organophosphorus Compounds; D011091:Polyesters; D054813:Polyhydroxyalkanoates; D011108:Polymers; D011140:Polyurethanes; C108974:poly(phosphazene); C016240:polycaprolactone