Cyanoximes as effective and selective co-crystallizing agents.
The ability of cyanoxime-based synthons to act as versatile synthetic tools for the construction of co-crystals is demonstrated through the preparation and structural characterization of seven co-crystals. Cyanoximes can bind effectively to both five-membered and six-membered N-heterocyclic hydrogen-bond acceptors, and they also display selectivity towards the best acceptor (as determined using semi-empirical AM1 calculations) in ditopic compounds.
Aakeröy
Christer B
CB
Department of Chemistry, Kansas State University, Manhattan, KS, 66506, aakeroy@ksu.edu.
Salmon
Debra J
DJ
Smith
Michelle M
MM
Desper
John
J