Assessing the determination of salivary electrolytes and anti-Ro and anti-La antibodies for the diagnosis of Sjögren's syndrome (SS).
The aim of this study was to assess changes in salivary electrolyte flow and composition and the presence of anti-Ro/SSA and anti-La/SSB serum and saliva antibodies and their implications for the non-invasive diagnosis of SS.


METHODS
73 patients were studied, divided into the following experimental groups: primary Sjögren syndrome (SSp) (n=15), secondary SS (SSs) (n=17), dry mouth, dry eye without Sjögren's syndrome (BO) (n=20) and healthy controls (C) (n=21). We conducted a baseline assessment of salivary flow and saliva sampling for the measurement of sodium, chlorine, potassium, calcium and phosphate electrolytes, and the determination of anti-Ro/SSA and La/SSB antibodies; a serum sampling was made to assess antibody positivity.


RESULTS
Salivary flow in SSp, SSs and BO was significantly lower (p<0.001) relative to C. The salivary composition of SS showed an increase of inorganic components. Anti-Ro/SSA and anti-La/SSB antibodies occurred more frequently in serum and saliva in SS patients compared with BO and C, with higher frequency of positivity in serum compared with saliva.


CONCLUSIONS
Our results suggest new tools that could aid the non-traumatic diagnosis of the origin of hyposalivation.
Busamia
Beatriz
B
Faculty of Dentistry, National University of Cordoba, Argentina. beabusamia@hotmail.com
Gonzales-Moles
Miguel-Angel
MA
Mazzeo
Marcelo
M
Linares
Jorge
J
Demarchi
Marcela
M
Gobbi
Carla
C
Albiero
Eduardo
E
Finkelberg
Ana
A
D000974:Antibodies, Antinuclear / Q000032:analysis* / Q000097:blood; D004573:Electrolytes / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry*; D012859:Sjogren's Syndrome / Q000097:blood / Q000175:diagnosis*
D000974:Antibodies, Antinuclear; D004573:Electrolytes; C035356:SS-A antibodies; C035357:SS-B antibodies