Acute promyelocytic leukemia treated with idarubicin complicated by focal segmental glomerulosclerosis.
The authors report a 9-year-old boy presenting with a left cerebral ischemic infarction as the first manifestation of acute promyelocytic leukemia. During consolidation chemotherapy, the patient developed nephrotic syndrome and a renal biopsy revealed focal segmental glomerulosclerosis (FSGS). Remission in bone marrow was achieved with chemotherapy, however, new intracranial ischemic areas developed on follow-up. Acute promyelocytic leukemia complicated by FSGS has not been previously reported in children. There may be a relationship between anthracycline treatment and FSGS. Thrombosis could be related with both leukemia and nephrotic syndrome, here thrombosis was the initial symptom, before FSGS was diagnosed.
Bariş
Safa
S
Departments of Pediatrics, Pediatric Hematology-Oncology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Ozdil
Mine
M
Topal
Nilüfer
N
Doğru
Omer
O
Ozdemir
Nihal
N
Sever
Lale
L
Albayram
Sait
S
Kiliçaslan
Işin
I
Celkan
Tiraje
T
D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D002648:Child; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology*; D006801:Humans; D015255:Idarubicin / Q000009:adverse effects*; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications / Q000188:drug therapy*; D008297:Male; D009404:Nephrotic Syndrome / Q000209:etiology; D013927:Thrombosis / Q000209:etiology
D000903:Antibiotics, Antineoplastic; D015255:Idarubicin