title: High seroprevalence of neutralizing capacity against human metapneumovirus in all age groups studied in Bonn, Germany.
abstract: Human metapneumovirus (hMPV) infections occur frequently despite high rates of perpetual seroprevalence for all age groups. Analyses of approximately 2,000 archived, randomly selected serum samples demonstrated that neutralizing capacities remain high, with a minor decrease for individuals over 69 years of age, leading to the hypothesis that reinfections occur because humoral immune responses play minor roles in the clearance of hMPV infections.
authors.affiliation: Institute for Virology, University of Bonn Medical Centre, Bonn, Germany.
authors.forename: Jessica
authors.initials: J
authors.lastname: Lüsebrink
authors.forename: Christoph
authors.initials: C
authors.lastname: Wiese
authors.forename: Anne
authors.initials: A
authors.lastname: Thiel
authors.forename: Ramona-Liza
authors.initials: RL
authors.lastname: Tillmann
authors.forename: Vanessa
authors.initials: V
authors.lastname: Ditt
authors.forename: Andreas
authors.initials: A
authors.lastname: Müller
authors.forename: Oliver
authors.initials: O
authors.lastname: Schildgen
authors.forename: Verena
authors.initials: V
authors.lastname: Schildgen
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D057134:Antibodies, Neutralizing / Q000097:blood / Q000276:immunology; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005858:Germany; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D029121:Metapneumovirus / Q000276:immunology; D008875:Middle Aged; D009500:Neutralization Tests; D018184:Paramyxoviridae Infections / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral