title: Hydrogenative desulphurization of thienopyrrolizinones: an easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity.
abstract: Attempts in view to dearomatize some previously reported tripentones with potent antineoplastic activities led in thiophene series to an unexpected hydrogenative desulphurization reaction. The resulting (Z)-phenethylidenepyrrolizinones were tested in vitro over human epidermoid carcinoma KB cell line. The results of this biological evaluation indicated that the tricyclic core of our model can be cleaved with a partial respect of the activity.
authors.affiliation: Centre d'Etudes et de Recherche sur le Médicament de Normandie, UPRES EA 4258, FR CNRS 3038 INC3M UFR des Sciences Pharmaceutiques, Université de Caen Basse Normandie, Bd Becquerel, 14032 Caen cedex France.
authors.forename: Vittoria
authors.initials: V
authors.lastname: Perri
authors.forename: Christophe
authors.initials: C
authors.lastname: Rochais
authors.forename: Jana
authors.initials: J
authors.lastname: Sopkova-de Oliveira Santos
authors.forename: Rémi
authors.initials: R
authors.lastname: Legay
authors.forename: Thierry
authors.initials: T
authors.lastname: Cresteil
authors.forename: Patrick
authors.initials: P
authors.lastname: Dallemagne
authors.forename: Sylvain
authors.initials: S
authors.lastname: Rault
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000633:toxicity*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013455:Sulfur / Q000737:chemistry*; D013874:Thiopental / Q000737:chemistry* / Q000633:toxicity; D013876:Thiophenes / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D011758:Pyrroles; D013876:Thiophenes; D013455:Sulfur; D013874:Thiopental