Defending the genome in tudor style.
Repression of transposable elements is crucial for the survival of germ cells. In this issue of Developmental Cell, Shoji et al. provide evidence that a Tudor domain protein TDRD9 partners with MIWI2 to specifically silence LINE-1 transposons in the fetal germline of male mice.
van der Heijden
Godfried W
GW
Department of Embryology, Carnegie Institution, Baltimore, MD 21218, USA.
Bortvin
Alex
A
D000818:Animals; D016678:Genome; D008297:Male; D051379:Mice; D034741:RNA, Small Interfering / Q000378:metabolism; D018626:Retroelements; D017411:Ribonucleoproteins, Small Nuclear / Q000737:chemistry / Q000378:metabolism*
D034741:RNA, Small Interfering; D018626:Retroelements; D017411:Ribonucleoproteins, Small Nuclear