[Vagal modulation of nociception in experimental model of viscreal pain].
Systemic control mechanisms of pain are based on interplay between nervous autonomic and immune systems. The aim of this study was to examine a possible role of the vagus nerve in regulation of nocyception. Peritoneal inflammation increased vagal activity. Pretreatment of PTX had an analgesic effect confirmed by amount of WT and decreased vagal activity. The vagotomy decreased nociceptive threshold.
Ciesielczyk
Katarzyna
K
Katedra Patofizjologii, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków, Poland. ckatarzyna@op.pl
Zurowski
Daniel
D
Nowak
Łukasz
Ł
Thor
Piotr J
PJ
D000818:Animals; D008297:Male; D009434:Neural Pathways / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology*; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology* / Q000517:prevention & control; D010431:Pentoxifylline / Q000008:administration & dosage; D010523:Peripheral Nervous System Diseases / Q000150:complications* / Q000503:physiopathology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014628:Vagotomy; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology*; D014781:Viscera / Q000187:drug effects / Q000294:innervation*
D010431:Pentoxifylline