Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents.
A series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv (MTB), Mycobacterium smegmatis (MC(2)), and Mycobacterium fortuitum following the broth micro dilution assay method. Compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (INH) and rifampicin (RIF) and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against multi-drug resistant tuberculosis.
Eswaran
Sumesh
S
Anthem Biosciences Pvt Ltd, 49 Bommasandra Industrial Area, Bommasandra, Bangalore 560 099, Karnataka, India.
Adhikari
Airody Vasudeva
AV
Pal
Nishith K
NK
Chowdhury
Imran H
IH
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D009161:Mycobacterium / Q000187:drug effects / Q000502:physiology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D006835:Hydrazones; D011804:Quinolines