[Meta-analysis of the effects on hormone replacement therapy and oral contraceptives associated with female lung cancer risk].
OBJECTIVE
To evaluate the effects of hormone replacement therapy (HRT) and oral contraceptives (OCs) on lung cancer risk in women.


METHODS
We retrieved studies by systematically searching Medline and other computerized databases. Pooled odds ratios (OR) were appropriately derived from fixed-effects or, in the presence of heterogeneity, random-effects models.


RESULTS
Twelve studies were identified including 3 cohort studies and 9 case-control studies. The OR value associated with HRT was 0.88 (95% CI: 0.77-1.01). Subgroup analyses by smoking revealed that the OR value associated with HRT in smokers' and non-smokers' women were 0.76(95% CI: 0.61-0.95) and 0.78 (95% CI: 0.64-0.95), respectively. There was no statistical relationship between lung cancer risk and OCs (OR = 0.95; 95% CI: 0.83-1.20).


CONCLUSIONS
The results suggest a potential decreased risk of female lung cancer might be associated with HRT. Additional well-designed studies are warranted to validate these findings.
Chen
Xing
X
School of Public Health, Fujian Medical University, Fuzhou 350004, China. xiaoge8419@163.com
Cai
Lin
L
D000328:Adult; D002289:Carcinoma, Non-Small-Cell Lung / Q000139:chemically induced / Q000453:epidemiology; D016022:Case-Control Studies; D015331:Cohort Studies; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
D003278:Contraceptives, Oral, Hormonal