title: Septoplasty retards midfacial growth in a rabbit model.
abstract: OBJECTIVE
  Septoplasty in the prepubertal age group is a controversial operation because of concerns regarding retardation of subsequent midfacial growth. This study uses a validated rabbit snout model to determine if septoplasty results in midfacial growth retardation, and if the retardation can be averted by replacing resected cartilage with a porous polyethylene implant.
  
  
  METHODS
  Prospective controlled animal study.
  
  
  METHODS
  Sixteen 9-week-old New Zealand white rabbits were divided into four groups: two control and two experimental. The experimental groups both underwent conservative submucoperichondrial surgical excision of a portion of their septum, leaving a generous dorsal and caudal septal strut for nasal support similar to what would be done clinically in humans. One of the experimental groups had replacement of the resected area by a rigid porous polyethylene graft, and in the other experimental group the resected area was left empty. Cephalometric measurements were performed on radiographs taken at the time of implantation, and at sacrifice when the rabbits were mature at 24 weeks of age.
  
  
  RESULTS
  There were significant disturbances in snout growth between experimental and control groups, and no significant differences between the two experimental groups or between the two control groups.
  
  
  CONCLUSIONS
  These data demonstrate midfacial growth retardation after conservative septoplasty in young rabbits, and that this retardation could not be averted by replacing the resected cartilage with a porous polyethylene graft. These data are in agreement with human studies.
authors.affiliation: Department of Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Kevin K
authors.initials: KK
authors.lastname: Wong
authors.forename: Sergei
authors.initials: S
authors.lastname: Filatov
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Kibblewhite
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002508:Cephalometry; D005260:Female; D008445:Maxillofacial Development / Q000502:physiology*; D023421:Models, Animal; D009300:Nasal Septum / Q000000981:diagnostic imaging / Q000601:surgery*; D011095:Polyethylenes; D011446:Prospective Studies; D019736:Prostheses and Implants; D011817:Rabbits; D011859:Radiography; D012225:Rhinoplasty / Q000379:methods*
chemical_list: D011095:Polyethylenes