[Changes in the thyroid activity and influence of dehydroepiandrosterone-sulfate under the cold and not cold influence].
The dehydroepiandrosterone-sulfate (DHEAS) effect on thyroxine (T4) and triiodothyronine (T3) levels, after the multiple (for 19 days, 1 hr a day) cold (+4 degrees) or stress without cold factor (agitation of rats on the laboratory scrambler) and the possible participation of mu-opioid receptors in this DHEAS effect in male rats. It is shown that DHEAS (30 mg/kg) caused the additional increased T4 and T3 levels indicated the activation of thyroid system. Under multiple stress-factor, the expressed DHEAS-dependent activation of thyroid system, in contrast to the cold-factor, is observed not immediately after action, but only 30 and 120 min after its curtailment, but it is not revealed without DHEAS in the studied time interval. The introduction antagonist of opioid receptor antagonist naltrexone at the dose of 0.1 mg/kg, which it selectively blocks mu-opioid receptors, removes the additional thyroid activation effect of DHEAS, both in cold and in stress factor, indicating the realization in both cases of this DHEAS effect through the mu-opioid receptors, but under the stress-factor but not cold influence the observed phenomenon is set aside time to 30, to 120 min.
Obut
T A
TA
Saryg
S K
SK
Erdynieva
T A
TA
Dement'eva
T Iu
TIu
D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects*; D019314:Dehydroepiandrosterone Sulfate / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D009271:Naltrexone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013312:Stress, Physiological; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D017450:Receptors, Opioid, mu; D014284:Triiodothyronine; D019314:Dehydroepiandrosterone Sulfate; D009271:Naltrexone; D013974:Thyroxine