Homogeneous gold-catalyzed oxidative carboheterofunctionalization of alkenes.
Homogeneous carboamination, carboalkoxylation and carbolactonization of terminal alkenes are realized via oxidative gold catalysis, providing expedient access to various substituted N- or O-heterocycles. Deuterium-labeling studies established the anti nature of the alkene functionalization and the indispensible role of Au(I)/Au(III) catalysis. This study constitutes the first example of catalytically converting C(sp(3))-Au bonds into C(sp(3))--C(sp(2)) bonds in a cross-coupling manner and opens new opportunities to study gold alkene catalysis where alkylgold intermediates can be readily functionalized intermolecularly.
Zhang
Guozhu
G
Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California 93106, USA.
Cui
Li
L
Wang
Yanzhao
Y
Zhang
Liming
L