title: Drug use and dosing in chronic kidney disease.
abstract: One of the most important drug-related problems in patients with chronic kidney disease (CKD) is medication dosing errors. Many medications and their metabolites are eliminated through the kidney. Thus, adequate renal function is important to avoid toxicity. Patients with renal impairment often have alterations in their pharmacokinetic and pharmacodynamic parameters. The clearance of drugs eliminated primarily by renal filtration is decreased by renal disease. Therefore, special consideration should be taken when these drugs are prescribed to patients with impaired renal function. Despite the importance of dosage adjustment in patients with CKD, such adjustments are sometimes ignored. Physicians and pharmacists can work together to accomplish safe drug prescribing. This task can be complex and require a stepwise approach to ensure effectiveness, minimise further damage and prevent drug nephrotoxicity.
authors.affiliation: Clinical Pharmacy Programme, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia. yahaya@usm.my
authors.forename: Yahaya
authors.initials: Y
authors.lastname: Hassan
authors.forename: Rowa'J
authors.initials: R
authors.lastname: Al-Ramahi
authors.forename: Noorizan
authors.initials: N
authors.lastname: Abd Aziz
authors.forename: Rozina
authors.initials: R
authors.lastname: Ghazali
mesh_terms: D002908:Chronic Disease; D003663:Decision Trees; D011307:Drug Prescriptions / Q000592:standards*; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism* / Q000503:physiopathology; D055553:Prescription Drugs / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D055553:Prescription Drugs