Protective effect of fish oil on changes in the activities of membrane-bound ATPases and mineral status in experimentally induced myocardial infarction in Wistar rats.
The present study evaluated the protective effect of fish oil in isoproterenol-induced myocardial infarction in rats. The results of the present study indicate that the IPH administration decreases the activities of membrane-bound ATPases compared to control animals. Fish oil pretreatment brought about significant increase in the activity of these membrane-bound ATPases in IPH (isoproterenol hydrochloride)-treated animals. Significant increase in serum potassium level with concomitant decrease in the values of sodium, magnesium, and calcium were observed in IPH-treated rats compared to control rats, fish oil pretreatment reversed these changes to near normal. Significant elevation of sodium and calcium levels with concomitant decrease in the levels of potassium and magnesium were observed in the myocardial tissue of IPH-administered rats compared to control rats, fish oil pretreatment followed by IPH administration brought these levels to near normal. The levels of lipid peroxidation (LPO) in both serum and tissue were increased in IPH-treated rats compared with control rats, whereas pretreatment with fish oil in IPH-treated rats maintained near-normal LPO levels. The results of the present study reveals that the pretreatment of fish maintains the activities of membrane-bound ATPases and the mineral levels at near normal by the inhibition of lipid peroxidation.
Padma
Viswanadha Vijaya
VV
Department of Biotechnology, Bharathiar University, Coimbatore, Tamil Nadu, India. padma.vijaya@gmail.com
Devi
Chennam Srinivasulu Shyamala
CS
Kalaiselvi
Palaniswamy
P
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002316:Cardiotonic Agents / Q000009:adverse effects* / Q000494:pharmacology; D002462:Cell Membrane / Q000378:metabolism*; D005395:Fish Oils; D007545:Isoproterenol / Q000009:adverse effects* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008670:Metals / Q000097:blood; D008903:Minerals / Q000097:blood*; D009203:Myocardial Infarction / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D002316:Cardiotonic Agents; D005395:Fish Oils; D008670:Metals; D008903:Minerals; D000251:Adenosine Triphosphatases; D007545:Isoproterenol