title: 6-Substituted 2-(N-trifluoroacetylamino)imidazopyridines induce cell cycle arrest and apoptosis in SK-LU-1 human cancer cell line.
abstract: A series of 6-substituted 2-(N-trifluoroacetylamino)imidazopyridines have been synthesized and their bioactivities were evaluated. Compounds 6a, 6c, and 11a were the most active compounds with modest cytotoxic activity against six human cancer cell lines U251 (glioma), PC-3 (prostate), K-562 (leukemia), HCT-15 (colon), MCF7 (breast) and SK-LU-1 (lung). The cell cycle analysis showed that compounds 6a, 6c, and 11a induce a G2/M phase cell cycle arrest on SK-LU-1 cell line where inhibition of CDK-1 and CDK-2 may be implicated.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, México 04510, DF, México.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Martínez-Urbina
authors.forename: Alejandro
authors.initials: A
authors.lastname: Zentella
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Vilchis-Reyes
authors.forename: Angel
authors.initials: A
authors.lastname: Guzmán
authors.forename: Omar
authors.initials: O
authors.lastname: Vargas
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Ramírez Apan
authors.forename: José Luis
authors.initials: JL
authors.lastname: Ventura Gallegos
authors.forename: Eduardo
authors.initials: E
authors.lastname: Díaz
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D016203:CDC2 Protein Kinase / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D005461:Fluorine / Q000737:chemistry*; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000188:drug therapy; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D007093:Imidazoles; D011725:Pyridines; D005461:Fluorine; D016203:CDC2 Protein Kinase