title: [Modulation of nuclear receptor action and regulation of medicines biotransformation].
abstract: Nuclear receptors are transcription factors that are essential in embryonic development, cellular differentiation, metabolism. Ligand-regulated nuclear PXR receptor responds to diverse arrays of chemically distinct ligands, xenobiotics, drugs and regulates expression of the genes involved in xenobiotic and drug metabolism. The structural basis of the receptor provides interaction with a variety of ligands which are agonists or antagonists. Nuclear receptors researches are important for design of metabolism regulating drugs and in drug interaction studies.
authors.forename: S N
authors.initials: SN
authors.lastname: Larina
authors.forename: N V
authors.initials: NV
authors.lastname: Chebyshev
authors.forename: E V
authors.initials: EV
authors.lastname: Shikh
mesh_terms: D000818:Animals; D001711:Biotransformation; D015195:Drug Design; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D000077297:Pregnane X Receptor; D011987:Receptors, Steroid / Q000378:metabolism*; D015262:Xenobiotics / Q000493:pharmacokinetics*
chemical_list: D000077297:Pregnane X Receptor; D011987:Receptors, Steroid; D015262:Xenobiotics