title: Impact of double-balloon enteroscopy findings on the management of Crohn's disease.
abstract: OBJECTIVE
  It is estimated that 10%-30% of Crohn's disease (CD) patients have small-bowel lesions, but the exact frequency and clinical relevance of these findings are unknown. Double-balloon enteroscopy (DBE) enables endoscopic visualization of the small bowel. The aim of this study was to evaluate the use of DBE for detecting small-bowel lesions in CD patients suspected of having small-bowel involvement. Furthermore, the clinical impact of adjusting treatment in these patients was assessed.
  
  
  METHODS
  A prospective study was performed in a tertiary referral center. CD patients suspected of small-bowel involvement and in whom distal activity had previously been excluded were included. All patients underwent DBE, followed by step-up therapy in patients with small-bowel lesions. The presence of small-bowel lesions during DBE was noted and clinical outcome was assessed after adjusting therapy.
  
  
  RESULTS
  Thirty-five patients (70%) showed small-bowel lesions; these lesions could not be assessed by conventional endoscopy in 23 (46%). At 1-year follow-up, step-up therapy in 26 patients (74%) led to clinical remission in 23 (88%). This was confirmed by a significant decrease in Crohn's disease activity index and mucosal repair on second DBE.
  
  
  CONCLUSIONS
  DBE showed a high frequency of small-bowel lesions in known CD patients with clinically suspected small-bowel activity. Most of these lesions were not accessible for conventional endoscopy. Adjusting treatment in patients with small-bowel CD involvement led to clinical remission and mucosal repair in the majority of cases.
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. p.mensink@erasmusmc.nl
authors.forename: Peter B F
authors.initials: PB
authors.lastname: Mensink
authors.forename: Huseyin
authors.initials: H
authors.lastname: Aktas
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Zelinkova
authors.forename: Rachel L
authors.initials: RL
authors.lastname: West
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Kuipers
authors.forename: Christien J
authors.initials: CJ
authors.lastname: van der Woude
mesh_terms: D000328:Adult; D000368:Aged; D002404:Catheterization; D016009:Chi-Square Distribution; D003424:Crohn Disease / Q000473:pathology* / Q000628:therapy; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D016896:Treatment Outcome