[Role of pendoxifiline (PTX) in different and cute and chronic models of pain in rats].
Pentoxifilne (PTX) is a non specific inhibitor of cytokines release, which suppress mainly TNF production. The aim of this study was to evaluate behavioural activity changes in response to acute and chronic nociceptive stimulus. PTX was more effective in neuropathic pain than acute pain model. Use of cytokine inhibitors might offer new strategies of drug-resistant chronic pain treatment.
Nowak
Łukasz
Ł
Katedra Patofizjologii, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków, Poland. lukaszn@cm-uj.krakow.pl
Zurowski
Daniel
D
Garlicki
Jarosław
J
Thor
Piotr J
PJ
D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D016207:Cytokines / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000601:surgery; D009619:Nociceptors / Q000187:drug effects / Q000378:metabolism; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology*; D010431:Pentoxifylline / Q000008:administration & dosage* / Q000378:metabolism*; D011292:Premedication; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects
D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D010431:Pentoxifylline