Synthesis and antimicrobial activity of 2-fluorophenyl-4,6-disubstituted [1,3,5]triazines.
A series of 2-fluorophenyl-4,6-disubstituted [1,3,5]triazines (1) and (2) were synthesized and evaluated for their antimicrobial activity against three representative gram-positive bacteria and two fungi. The structure-activity relationship (SAR) demonstrates that the 3- or 4-fluorophenyl component attached directly to the triazine ring was essential for activity. Of these compounds, 14, 15, and 25 demonstrated significant activity against all selected organisms compared to control. These compounds were generally nontoxic and may prove useful as antimicrobial agents.
Saleh
Mona
M
ProMetic BioSciences Inc, 500 Boulevard Cartier Ouest, Laval, Québec, Canada.
Abbott
Shaun
S
Perron
Valérie
V
Lauzon
Caroline
C
Penney
Christopher
C
Zacharie
Boulos
B
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000502:physiology; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000502:physiology; D008826:Microbial Sensitivity Tests / Q000379:methods; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology*
D000890:Anti-Infective Agents; D014227:Triazines