title: Saponins and polyphenols from Fadogia ancylantha (makoni tea).
abstract: Three new saponins (1-3) and a known saponin, together with four known polyphenolic compounds, have been isolated from the fermented and dried leaves of Fadogia ancylantha (Makoni tea). The structures of compounds 1-3 were established by analysis of their spectroscopic data. Both an ethanol-water extract of F. ancylantha and its phenolic constituents showed significant free-radical-scavenging and antimicrobial activities. No cytotoxicity, as evaluated by analysis of hypodiploid nuclei in HUVEC cells using propidium iodide staining, was observed for either the plant crude extract or its constituents.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, University of Salerno, Via Ponte Don Melillo, 84084, Fisciano, Salerno, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Mencherini
authors.forename: Patrizia
authors.initials: P
authors.lastname: Picerno
authors.forename: Pasquale
authors.initials: P
authors.lastname: Del Gaudio
authors.forename: Michela
authors.initials: M
authors.lastname: Festa
authors.forename: Anna
authors.initials: A
authors.lastname: Capasso
authors.forename: Rita
authors.initials: R
authors.lastname: Aquino
mesh_terms: D004727:Endothelium / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007558:Italy; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D059808:Polyphenols; D019666:Rubiaceae / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013662:Tea / Q000737:chemistry*
chemical_list: C548193:3-O-beta-D-glucopyranosyl-3-beta-hydroxyolean-12-en-28-oic acid 28-O-(alpha-L-rhamnopyranosyl-(1-2)-beta-D-glucopyranosyl)ester; C548194:3-O-beta-D-glucopyranosyl-3-beta-hydroxyolean-12-en-28-oic acid 28-O-(beta-D-apiofuranosyl-(1-2)-beta-D-glucopyranosyl)ester; C548195:3-O-beta-D-glucopyranosyl-3-beta-hydroxyolean-12-en-28-oic acid 28-O-(beta-D-glucopyranosyl-(1-2)-beta-D-galactopyranosyl)ester; D005419:Flavonoids; D016166:Free Radical Scavengers; D010636:Phenols; D059808:Polyphenols; D012503:Saponins; D013662:Tea; D009828:Oleanolic Acid