title: Hepatoprotective potential of extracts from seeds of Areca catechu and nutgalls of Quercus infectoria.
abstract: Aqueous extracts from seeds of Areca catechu L. (Arecaceae) (AC) and nutgalls of Quercus infectoria Oliv. (Fagaceae) (QI) were investigated for their hepatoprotective potential by studying their antioxidant capacity using four different methods, by determining their in vitro anti-inflammatory activity against 5-lipoxygenase, and by evaluating their hepatoprotective potential against liver injury induced by carbon tetrachloride (CCl(4)) in rats. AC and QI extracts exhibited potent antioxidant and anti-inflammatory activities. Treatment of rats with AC and QI extracts reversed oxidative damage in hepatic tissues induced by CCl(4). It is suggested that extracts rich in either condensed or hydrolysable tannins and known for their potent antioxidant and anti-inflammatory activities, may potentially confer protection against oxidative stress-induced liver injury. These data should contribute to evidence-based traditional medicines for anti-inflammatory and hepatoprotective effects of both extracts.
authors.affiliation: Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand. pypph@mahidol.ac.th
authors.forename: Pimolpan
authors.initials: P
authors.lastname: Pithayanukul
authors.forename: Saruth
authors.initials: S
authors.lastname: Nithitanakool
authors.forename: Rapepol
authors.initials: R
authors.lastname: Bavovada
mesh_terms: D000818:Animals; D001114:Areca / Q000196:embryology*; D008099:Liver / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D029963:Quercus / Q000196:embryology*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*
chemical_list: D010936:Plant Extracts