title: Clinicopathological study and treatment outcomes of 121 cases of ameloblastomas.
abstract: The aim of this paper is to evaluate the clinical, radiographic, and histopathological findings and treatment modalities in all cases of ameloblastomas treated at the Sao Paulo Cancer Hospital, between 1953 and 2003. 121 case reports were retrieved from the medical files. Data were reviewed and statistical analysis was performed using Kaplan-Meyer method and Cox proportional risk model. The patients' age ranged from 2 to 82 years (mean 33.2 years), with a slight female prevalence. Most cases were located in the posterior mandible (80%). Radiographically, 60% showed a multilocular pattern. 113 casees were solid ameloblastomas, and plexiforme subtype was the most common. Solid tumours were treated by wide resection, curettage and criosurgery, or curettage alone, and unicystic tumours by curettage and/or cryotherapy. The global mean recurrence rate was 22%, with a mean follow-up of 9.7 years. The ameloblastomas were predominantly solid, affecting the posterior mandible. Important factors for outcome were radiographically multilocular lesions, the presence of ruptured basal cortical bone and histologically follicular tumours.
authors.affiliation: Department of Stomatology, A.C. Camargo Cancer Hospital, Sao Paulo, Brazil. eduardofregnani@me.com
authors.forename: E R
authors.initials: ER
authors.lastname: Fregnani
authors.forename: D E
authors.initials: DE
authors.lastname: da Cruz Perez
authors.forename: O P
authors.initials: OP
authors.lastname: de Almeida
authors.forename: L P
authors.initials: LP
authors.lastname: Kowalski
authors.forename: F A
authors.initials: FA
authors.lastname: Soares
authors.forename: F
authors.initials: F
authors.lastname: de Abreu Alves
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000564:Ameloblastoma / Q000145:classification / Q000453:epidemiology*; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003452:Cryosurgery / Q000706:statistics & numerical data; D003475:Curettage / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007573:Jaw Neoplasms / Q000453:epidemiology*; D008137:Longitudinal Studies; D008297:Male; D008339:Mandibular Neoplasms / Q000453:epidemiology; D008441:Maxillary Neoplasms / Q000453:epidemiology; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D010027:Osteotomy / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012737:Sex Factors; D016896:Treatment Outcome; D044465:White People / Q000706:statistics & numerical data; D055815:Young Adult