title: Antihyperglycemic activity of naphthylchalcones.
abstract: The purpose of the present work was to investigate, following previous works, naphthylchalcones as antihyperglycemic agent in glucose loaded animal model, insulin secretion as well as the action of these compounds on glucose uptake in a target tissue of insulin. The naphthylchalcones were found to have an acute serum glucose-lowering effect in hyperglycemic normal rats. In addition, chalcones 2 and 4 stimulated significantly the insulin secretion induced by glucose. These results suggest that the presence of nitro group and their position in the phenyl rings are responsible for the antihyperglycemic activity of chalcones. Additionally, the effect of chalcones on serum glucose-lowering seems to be a consequence of insulin secretion and these chalcones represent potential compounds with strong antihyperglycemic properties.
authors.affiliation: Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina Campus Universitário, Bairro Trindade, Cx. Postal 5069, CEP: 88040-970, Florianópolis, Santa Catarina, Brazil.
authors.forename: Rosangela Guollo
authors.initials: RG
authors.lastname: Damazio
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Zanatta
authors.forename: Luisa Helena
authors.initials: LH
authors.lastname: Cazarolli
authors.forename: Louise Domeneghini
authors.initials: LD
authors.lastname: Chiaradia
authors.forename: Alessandra
authors.initials: A
authors.lastname: Mascarello
authors.forename: Ricardo José
authors.initials: RJ
authors.lastname: Nunes
authors.forename: Rosendo Augusto
authors.initials: RA
authors.lastname: Yunes
authors.forename: Fátima Regina Mena
authors.initials: FR
authors.lastname: Barreto Silva
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D047188:Chalcones / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D047188:Chalcones; D007004:Hypoglycemic Agents; D007328:Insulin