Predictors of vascular events after ischemic stroke: the China ischemic stroke registry study.
OBJECTIVE
To measure the risk of vascular event occurrence among postischemic stroke patients in mainland China.


METHODS
In this multicenter prospective stroke registry study, we enrolled 1,951 patients diagnosed with acute ischemic stroke. Demographic data, prestroke risk factors, severity of neurological deficits and disability graded on the National Institutes of Health Stroke Scale (NIHSS), and modified Rankin Scale scores of each patient were measured and recorded. Patients were followed up regularly for 12 months after recruitment. Clinical endpoints were defined as occurrence of vascular events or death.


RESULTS
We detected 103 cases with nonfatal vascular events and 27 cases that died of vascular events. Cumulative incidences of total vascular events, cerebrovascular events, and coronary artery diseases were 7.2, 5.0, and 1.8%, respectively, at 12 months after the initial ischemic stroke. Concomitant atherosclerotic-thrombotic diseases (HR, 1.68; 95% CI, 1.14-2.43) and baseline NIHSS (HR, 1.07; 95% CI, 1.03-1.11) were found to be the best predictors for further occurrence of a vascular event. Antiplatelet therapy (HR, 0.52; 95% CI, 0.35-0.77) is associated with a lower risk of further vascular events.


CONCLUSIONS
Our study provided valuable data on prognosis of acute ischemic stroke in Chinese patients.
Ding
Ding
D
Institute of Neurology, WHO Collaborating Center for Research and Training in Neuroscience, Huashan Hospital, Fudan University, Shanghai, China.
Lu
Chuan-Zhen
CZ
Fu
Jian-Hui
JH
Hong
Zhen
Z
D000208:Acute Disease; D002545:Brain Ischemia / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D002681:China; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D005843:Geography; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011379:Prognosis; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D013997:Time Factors; D016896:Treatment Outcome; D014652:Vascular Diseases / Q000175:diagnosis* / Q000401:mortality
D010975:Platelet Aggregation Inhibitors