title: Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of daily alcohol drinking on yearly changes in serum total and LDL cholesterol in Japanese men.
abstract: Reduced nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit 2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism, is reportedly associated with longevity in the Japanese population. The ND2-237Met genotype may exert resistance to atherogenic diseases, such as myocardial infarction or cerebrovascular disorders. To investigate whether ND2-237 Leu/Met polymorphism is associated with yearly changes in serum lipid levels, we conducted a longitudinal study of 107 healthy Japanese male subjects. Analysis of covariance revealed that the interaction between the ND2-237 Leu/Met genotypes and habitual drinking was significantly associated with yearly changes in serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC) levels (p=0.036 and p=0.006, respectively). In multiple regression analysis, daily drinking was significantly and positively associated with yearly changes in serum LDLC levels in men with ND2-237Met (p=0.026). After adjusting for covariates, yearly changes in serum LDLC levels were significantly lower in non-daily drinkers with ND2-237Met than in those with ND2-237Leu (p=0.047). These results suggest that ND2-237Met has a beneficial impact on yearly changes in serum LDLC in non-daily drinkers but not in daily drinkers.
authors.affiliation: Department of General Medicine, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Makita
authors.forename: Akatsuki
authors.initials: A
authors.lastname: Kokaze
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Ohtsu
authors.forename: Mamoru
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Naomi
authors.initials: N
authors.lastname: Matsunaga
authors.forename: Kanae
authors.initials: K
authors.lastname: Karita
authors.forename: Masao
authors.initials: M
authors.lastname: Yoshida
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Tanaka
authors.forename: Minoru
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Junichi
authors.initials: J
authors.lastname: Hayashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takashima
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kitamoto
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000097:blood / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood / Q000235:genetics; D008078:Cholesterol, LDL / Q000097:blood / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics; D005838:Genotype; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009245:NADH Dehydrogenase / Q000235:genetics*; D011110:Polymorphism, Genetic; D012044:Regression Analysis
chemical_list: D008078:Cholesterol, LDL; D004272:DNA, Mitochondrial; D002784:Cholesterol; D009245:NADH Dehydrogenase; C521326:NADH dehydrogenase subunit 2, human