[Ethanol elimination rate (beta60, beta-slope) in different age groups after intake of a moderate or high dose of alcohol].
Ethanol elimination rate (beta60) was measured in different age groups of men and women following its single intake at a dose of 0.8 g/kg body weight (experiment 1) and 2 g/kg (experiment 2). Samples of capillary blood were collected 20, 40, 60, 90, 120, and 300 min (experiment 1) or 360 min after the termination of the intake (experiment 2). The phase of alcohol elimination was deduced from the kinetic curve. Each alcohol dose was consumed during 1-2 minutes or 1-1.5 hours (experiments 1 and 2 respectively). The value of (beta60) in experiment 1 was estimated at 0.17 +/- 0.04 per thousand/hour in young men aged between 18-26 years, 0.22 per thousand/hour in adult men of 32-48 years, and 0.21 per thousand/hour in women aged between 19-41 years. The difference between alcohol elimination rates in young and adult men on the one hand and between young men and women on the other hand was statistically significant (p < 0.01 and p < 0.05 respectively). In the second experiment, ethanol elimination rate was practically identical in men of the above age groups (0.16 +/- 0. 02 per thousand/hour) and significantly higher than in 64-66 year-old men (0.14 +/- 0.03 per thousand/hour). The values of ethanol elimination rate in men of group 2 calculated by the Weedmark formula proved underestimated by 17 +/- 5% regardless of their age. Men of both age groups included in experiment 1 showed an alcohol excretion rate overestimated by 8 +/- 5% and 31 +/- 6% respectively compared with 10 +/- 7% in women. It is suggested that a single intake of alcohol may lead to an instantaneous rise in the hepatic concentration of ethanol unrelated to the consumed amount that however affects its metabolic rate. It is concluded that the duration of ethanol intake has greater effect on the rate of its elimination from the body than the amount of consumed alcohol, especially in alcohol-tolerant subjects.
Barinskaia
T O
TO
Smirnov
A V
AV
Salomatin
E M
EM
Shaev
A I
AI
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D013997:Time Factors; D055815:Young Adult
D000431:Ethanol