Association of the common fat mass and obesity associated (FTO) gene polymorphism with obesity in a Japanese population.
The association of the FTO gene polymorphism, rs9939609, with obesity was examined using the population of the Takahata study (n (M/F): 2,639 (1,168 / 1,470); age: 63.0 +/- 10.2 years), a Japanese community-based study. The effects of lifestyle-related factors, including nutritional intake and physical activities, on the association were also examined. Body mass index (BMI) was significantly associated with the FTO gene polymorphism (p<0.001). A case-control association study of the FTO gene polymorphism with obesity using multiple logistic regression analysis showed a significant association of the genotype AA (odds ratio, 1.53 [95% confidential interval, 1.04-2.24]) after adjustment for age and gender. Analysis to examine the differences in lifestyle-related factors among the genotype groups showed a significant difference in the energy expenditure for moderate to high-intensity physical activity (PA) (> or = 3.0 METs) (p=0.012) with a significant decrease toward the genotype AA (p=0.027). The effect of energy expenditure for moderate to high-intensity PA on the association of the polymorphism with obesity was then examined using study groups stratified based on the energy expenditure for moderate to high-intensity PA (Low-PA and High-PA). The BMI was significantly higher in the genotype AA in the Low-PA group (p=0.016) but not in the High-PA group (p=0.103). Furthermore, the genotype AA was significantly associated with obesity (odds ratio, 2.39 [95% confidential interval, 1.19-4.80]) in the Low-PA group but not in the High- PA group (p=0.650). The FTO gene, rs9939609, was associated with obesity, and the association was evident in subjects with low-PA, suggesting a PA-dependent association.
Karasawa
Shigeru
S
Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan.
Daimon
Makoto
M
Sasaki
Satoshi
S
Toriyama
Sayumi
S
Oizumi
Toshihide
T
Susa
Shinji
S
Kameda
Wataru
W
Wada
Kiriko
K
Muramatsu
Masaaki
M
Fukao
Akira
A
Kubota
Isao
I
Kawata
Sumio
S
Kayama
Takamasa
T
Kato
Takeo
T
D000368:Aged; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015992:Body Mass Index; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004032:Diet; D002149:Energy Intake; D004734:Energy Metabolism / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D016017:Odds Ratio; D005082:Physical Exertion; D011110:Polymorphism, Genetic / Q000235:genetics*; D011506:Proteins / Q000235:genetics*
D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human