title: [A case of locally recurrent rectal cancer responding to radiation and chemotherapy with S-1].
abstract: We describe a case of locally recurrent rectal cancer that was successfully treated with radiation and chemotherapy with S-1; this treatment resulted in long-term survival of the patient with a good performance status. A 51-year-old man underwent Hartmann's operation for advanced rectal cancer. At 6 months after the surgery, a pelvic computed tomography (CT) scan showed a local recurrence of the rectal cancer. The patient's serum CA19-9 level had increased to 3,200 U/mL. The tumor was unresectable, so that radiation therapy was administered to the pelvic region at a total dose of 56 Gy, followed by oral chemotherapy with S-1 for 2 years. After these treatments, the serum CA19-9 level returned to normal. No signs of tumor recurrence were observed as of 3 years and 5 months after the confirmation of local recurrence. A combination of radiation therapy and oral administration of S-1 could be a useful treatment for unresectable locally recurrent rectal cancer.
authors.affiliation: Department of Surgery, Shuwa General Hospital.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kuwabara
authors.forename: Naoto
authors.initials: N
authors.lastname: Fujiwara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakamura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Baba
authors.forename: Satoru
authors.initials: S
authors.lastname: Tamai
authors.forename: Kazumi
authors.initials: K
authors.lastname: Nakajima
authors.forename: Narihide
authors.initials: N
authors.lastname: Goseki
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004338:Drug Combinations; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010094:Oxonic Acid / Q000627:therapeutic use*; D012004:Rectal Neoplasms / Q000628:therapy*; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid