title: Thrombolysis for acute ischemic stroke--our experiences as part of SITS-MOST.
abstract: Thrombolysis with intravenous recombinant tissue plasminogen activator (rtPA) is the first evidence based treatment for acute ischemic stroke, which aims to reduce the cerebrovascular lesion. At University Department of Neurology, Sestre milosrdnice University Hospital, Zagreb, thrombolytic therapy with intravenous rtPA (alteplase) (Actilyse) for acute ischemic stroke was introduced in 2004. We present our results referring to demographic, time logistics and clinical outcome data as part of SITS-MOST (Safe Implementation of Thrombolysis in Stroke - MOnitoring STudy) and compare them with the results from other centers in Croatia and all other participating centers. Up to now, 56 patients (61% of male and 39% of female, average age 67 years) have been treated at our department with intravenous rt-PA (0.9 mg/kg body weight, maximum 90 mg), with 10% of the dose given as a bolus followed by 60-minute infusion. Our experiences with thrombolytic therapy with intravenous rt-PA (alteplase) (Actilyse) for acute ischemic stroke confirm the safety and the efficacy of this therapy.
authors.affiliation: University Department of Neurology, Reference Center for Neurovascular Disorders, Ministry of Health and Social Welfare of Republic of Croatia, Sestre milosrdnice University Hospital, Zagreb. mroje@mef.hr
authors.forename: Marina
authors.initials: M
authors.lastname: Roje-Bedeković
authors.forename: Vesna
authors.initials: V
authors.lastname: Vargek-Solter
authors.forename: Lejla
authors.initials: L
authors.lastname: Corić
authors.forename: Karla
authors.initials: K
authors.lastname: Sabolek
authors.forename: Tomislav
authors.initials: T
authors.lastname: Breitenfeld
authors.forename: Visnja
authors.initials: V
authors.lastname: Supanc
authors.forename: Vida
authors.initials: V
authors.lastname: Demarin
mesh_terms: D000368:Aged; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D008297:Male; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator