Chemokines and chemokine receptors in arthritis.
Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines. Chemokines may also be either inflammatory or homeostatic, however, these functions often overlap. Anti-chemokine and anti-chemokine receptor targeting may be therapeutically used in the future biological therapy of arthritis. Most data in this field have been obtained from animal models of arthritis as only very few human RA trials have been completed. However, it is very likely that various specific chemokine and chemokine receptor antagonists will be developed and administered to RA patients.
Szekanecz
Zoltan
Z
Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary, Europe. szekanecz@iiibel.dote.hu
Vegvari
Aniko
A
Szabo
Zoltan
Z
Koch
Alisa E
AE
D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology*; D018925:Chemokines / Q000145:classification / Q000276:immunology*; D016503:Drug Delivery Systems; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D018919:Neovascularization, Physiologic / Q000276:immunology*; D019707:Receptors, Chemokine / Q000276:immunology*; D013585:Synovitis / Q000276:immunology*
D018925:Chemokines; D019707:Receptors, Chemokine