[Preparation and in vitro evaluation of brucine-loaded polylacticacid nanoparticles].
OBJECTIVE
To prepare and evaluate brucine-loaded polylacticacid nanoparticles (Bru-PLA-NPs).


METHODS
The Bru-PLA-NPs were prepared by solvent diffusion method. The physical, chemical properties and in vitro release behavior of the prepared Bru-PLA-NPs were evaluated, respectively.


RESULTS
The mean particle size of the prepared Bru-PLA-NPs was 95 nm with polydispersity index of 0.362. The zeta potential was -15.68 mV. The mean loading and entrapment efficiency of Bru were 7% and 37%, respectively. Compared with Bru solution, an obvious sustained release behavior of Bru from Bru-PLA-NPs was observed in the in vitro release experiment.


CONCLUSIONS
The Bru-PLA-NPs prepared by solvent diffusion method exhibit small particle size, high Bru-loading efficiency, and obvious sustained release in vitro
Zhao
Jihui
J
Department of Pharmaceutics, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Liu
Zhaolin
Z
Xu
Jie
J
Yu
Yanyan
Y
Feng
Nianping
N
D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D013331:Strychnine / Q000031:analogs & derivatives* / Q000737:chemistry
D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); C083806:brucine; D013331:Strychnine