title: Potent transglutaminase inhibitors, aryl beta-aminoethyl ketones.
abstract: Aryl beta-aminoethyl ketones were discovered as potent inhibitors of tissue transglutaminase. Heteroaryl-like thiophene groups and N-benzyl N-t-butyl aminoethyl group are critical to the strong inhibitory activity of aryl beta-aminoethyl ketones.
authors.affiliation: Laboratory for Developmental Neurobiology, Brain Science Institute, Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Ozaki
authors.forename: Etsuko
authors.initials: E
authors.lastname: Ebisui
authors.forename: Kozo
authors.initials: K
authors.lastname: Hamada
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Goto
authors.forename: Akinobu Z
authors.initials: AZ
authors.lastname: Suzuki
authors.forename: Akiko
authors.initials: A
authors.lastname: Terauchi
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Mikoshiba
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D007659:Ketones / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D011503:Transglutaminases / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D007659:Ketones; D011503:Transglutaminases