title: Use of inbred mouse strains to map recognition receptors of MCMV infected cells in the NK cell gene locus.
abstract: Genetically distinct inbred strains of mice that differ in their susceptibility to mouse cytomegalovirus (MCMV) are invaluable for dissecting complex host-pathogen interactions. Their study has allowed the identification of host-resistance loci, including several activating NK cell receptors of major histocompatibility complex (MHC) class I. In this chapter, we provide a practical guide to the genetic mapping and functional characterization of NK cell receptors that control innate immunity against MCMV via specific recognition of infected cells.
authors.affiliation: Department of Human Genetics, McGill University, Montreal, QC, Canada.
authors.forename: Nassima
authors.initials: N
authors.lastname: Fodil-Cornu
authors.forename: Michal
authors.initials: M
authors.lastname: Pyzik
authors.forename: Silvia M
authors.initials: SM
authors.lastname: Vidal
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping / Q000379:methods*; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D005260:Female; D005786:Gene Expression Regulation; D056426:Genetic Loci / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D016678:Genome / Q000235:genetics; D005838:Genotype; D007113:Immunity, Innate / Q000235:genetics; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D018146:Muromegalovirus / Q000502:physiology*; D010641:Phenotype; D011247:Pregnancy; D055607:Receptors, Natural Killer Cell / Q000235:genetics*; D013379:Substrate Specificity
chemical_list: D018076:DNA, Complementary; D005819:Genetic Markers; D055607:Receptors, Natural Killer Cell