title: Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents.
abstract: A series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv (MTB), Mycobacterium smegmatis (MC(2)), and Mycobacterium fortuitum following the broth micro dilution assay method. Compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (INH) and rifampicin (RIF) and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against multi-drug resistant tuberculosis.
authors.affiliation: Anthem Biosciences Pvt Ltd, 49 Bommasandra Industrial Area, Bommasandra, Bangalore 560 099, Karnataka, India.
authors.forename: Sumesh
authors.initials: S
authors.lastname: Eswaran
authors.forename: Airody Vasudeva
authors.initials: AV
authors.lastname: Adhikari
authors.forename: Nishith K
authors.initials: NK
authors.lastname: Pal
authors.forename: Imran H
authors.initials: IH
authors.lastname: Chowdhury
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D009161:Mycobacterium / Q000187:drug effects / Q000502:physiology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D006835:Hydrazones; D011804:Quinolines