title: [Perioperative management for transurethral resection of bladder tumor (TUR-Bt) associated with congenital antithrombin III deficiency].
abstract: Congenital antithrombin III (ATIII) deficiency is a hereditary disease that predisposes to thromboembolic complications. We report perioperative management for twice in a patient with congenital ATIII deficiency. A 69-year-old man with congenital ATIII deficiency, with history of deep vein thrombosis (DVT) in his left popliteal vein, was scheduled for transurethral resection of bladder tumor (TUR-Bt). The plasma ATIII activity was 57% of normal vale. As ATIII concentrates 3,000U per day had been administered intravenously since the second day before the operation, the plasma ATIII activity was 147% on the operation day. TUR-Bt was performed in the lithotomy position under general anesthesia. ATIII concentrates 3,000 U per day were administered intravenously for two days after the operation and low molecular weight heparin (LMWH) 2,500 U per day was administered subcutaneously for five days after the operation. One year later he had a recurrence of bladder tumor. The plasma ATIII activity was 54%. ATIII concentrates 3,000 U per day had been administered intravenously since the three days before the operation. The second TUR-Bt was also performed in the lithotomy position under general anesthesia. ATIII concentrates 1,500 U per day were administered intravenously for three days after the operation. LMWH was not administered due to postoperative bleeding from the bladder. He had no thromboembolism during each perioperative period. The lithotomy position with fixation of both hips and both knees may decrease venous blood flow, increase muscle compartment pressure of the lower extremities, predispose to DVT in the lower extremity, and lead to pulmonary thromboembolism (PE). Control of blood coagulation and maintenance of sufficient venous blood flow in the lower extremities with ATIII adjuvant therapy and LMWH administration during the perioperative period are important for TUR-Bt in a patient with congenital ATIII deficiency to prevent DVT and PE.
authors.affiliation: Department of Anesthesiology, Teikyo University School of Medicine, Tokyo 173-8605.
authors.forename: Ju
authors.initials: J
authors.lastname: Mizuno
authors.forename: Shinya
authors.initials: S
authors.lastname: Kato
authors.forename: Schigenari
authors.initials: S
authors.lastname: Namai
authors.forename: Yoko
authors.initials: Y
authors.lastname: Komiya
authors.forename: Yukiharu
authors.initials: Y
authors.lastname: Kuwana
authors.forename: Shigeho
authors.initials: S
authors.lastname: Morita
mesh_terms: D000368:Aged; D000768:Anesthesia, General; D000925:Anticoagulants / Q000008:administration & dosage; D000990:Antithrombin III / Q000008:administration & dosage*; D020152:Antithrombin III Deficiency / Q000151:congenital*; D015653:Cystectomy / Q000379:methods*; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D019990:Perioperative Care; D011183:Postoperative Complications / Q000517:prevention & control; D011655:Pulmonary Embolism / Q000517:prevention & control; D014521:Urethra / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000601:surgery*; D020246:Venous Thrombosis / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D000990:Antithrombin III