title: Uveal inflammation in septic newborn foals.
abstract: BACKGROUND
  Septicemia in humans is described as a leading cause of uveitis, which eventually can induce blindness.
  
  
  OBJECTIVE
  Uveal inflammatory findings could be related to sepsis severity in newborn foals and might be used as an indirect indicator for survival.
  
  
  METHODS
  Seventy-four septic foals, 54 nonseptic foals, and 42 healthy foals.
  
  
  METHODS
  Prospective observational clinical study. A detailed blinded, ophthalmic examination was performed by boarded ophthalmologists on all admitted newborn foals. Foals were grouped as septic (when blood culture resulted positive or the sepsis score was > or =14), nonseptic, and controls. Based on blood culture results, the septic group was subdivided into bacteremic and nonbacteremic foals.
  
  
  RESULTS
  Blood culture was performed in 62/74 septic foals, from which 35 (56%) were bacteremic and 27 (44%) were non-bacteremic. Anterior uveitis was diagnosed in a significantly (P < .005) higher number of septic/bacteremic foals (14/35, 40%) than in septic/nonbacteremic foals (5/27, 19%), nonseptic foals (4/54, 7%), and control foals (0%). Anterior chamber fibrin was only observed in 4/14 (29%) septic/bacteremic foals with anterior uveitis. Anterior uveitis was also associated with posterior uveitis in 6/35 (19%) septic/bacteremic foals. The diagnosis of uveitis was related to nonsurvival (P = .001, odds ratio = 6.2, 95% confidence interval = 2.1-18.2).
  
  
  CONCLUSIONS
  Anterior uveitis is highly prevalent in septic newborn foals, especially in those with a positive blood culture, and it should be considered as a survival prognostic factor.
authors.affiliation: Servei d'Oftalmologia Veterinària, Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Leiva
authors.forename: T
authors.initials: T
authors.lastname: Peña
authors.forename: L
authors.initials: L
authors.lastname: Armengou
authors.forename: C
authors.initials: C
authors.lastname: Cesarini
authors.forename: L
authors.initials: L
authors.lastname: Monreal
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005260:Female; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D008297:Male; D011446:Prospective Studies; D018805:Sepsis / Q000150:complications / Q000662:veterinary*; D014605:Uveitis / Q000150:complications / Q000473:pathology / Q000662:veterinary*