Comparative study of the ocular irritation potential of various alkyl polyglucoside surfactants.
In the present work, we assessed the relationship between alkyl carbon chain length and ocular irritation potentials using the hen's egg test-chorioallantoic membrane (HET-CAM) and bovine corneal opacity and permeability (BCOP) assays using 5 commercial alkyl polyglucoside surfactants with different compositions of alkyl chain lengths (C(6)-C(16)). With HET-CAM, there was a good correlation between the proportion of C(10) alkyl polyglucoside and the eye irritation potential Q score (r(2) = 0.912, p = .011). There were no significant differences between the proportion of C(10) alkyl polyglucoside and corneal opacity in BCOP assays; however, there was a relatively high positive correlation between the proportion of C(10) alkyl carbon chain lengths and corneal permeability (r(2) = 0.736, p = .063).
Cho
Sun-A
SA
Skin Research Institute, AmorePacific R&D Center, Yongin-si, Korea.
Han
Ju-Hee
JH
An
Susun
S
Lee
Key Hyun
KH
Park
Jae-Hak
JH
Kim
Han Kon
HK
Lee
Tae Ryong
TR
D000818:Animals; D002417:Cattle; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000187:drug effects*; D003315:Cornea / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003318:Corneal Opacity / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D005960:Glucosides / Q000737:chemistry / Q000633:toxicity*; D015394:Molecular Structure; D010539:Permeability; D018570:Risk Assessment; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000737:chemistry / Q000633:toxicity*
D005960:Glucosides; D013501:Surface-Active Agents