title: Anion effects on anti-microbial activity of poly[1-vinyl-3-(2-sulfoethyl imidazolium betaine)].
abstract: Recent investigations in the anti-microbial properties of the functional polymers are predominantly focused on the structure of the cationic moieties. In the present study, we investigated that the nature of the anion present in polysulfobetaines affects activity against certain microorganisms and their anti-microbial properties have been rationalized in terms of the structure-activity relationship. Vinyl imidazolium-based polysulfobetaines were prepared by the quaternization of poly(N-vinyl imidazole) with sodium salt of 2-bromo ethanesulfonic acid. The bromide counter anion of the resulting polymer was exchanged with different anions to generate a series of polymers. These were characterized by FTIR, DSC, XRD, SEM, elemental analysis (C, H, N and S) and viscosity measurements. The anti-microbial activity studies were carried against three fungi (Aspergillus niger, Byssochlamys fulva and Mucor circenelliods) and two bacteria (Bacillus coagulans BTS-3 and Pseudomonas aeruginosa BTS-2). The nature of the anion affects the structure of polysulfobetaine by realignment of polymer chains. The anion-dependent anti-microbial properties of polysulfobetaines result from the interaction of the microbes at the polymer interface.
authors.affiliation: Department of Chemistry, Himachal Pradesh University, Shimla 171 005, India.
authors.forename: Godawari
authors.initials: G
authors.lastname: Garg
authors.forename: Ghanshyam S
authors.initials: GS
authors.lastname: Chauhan
authors.forename: Reena
authors.initials: R
authors.lastname: Gupta
authors.forename: J-H
authors.initials: JH
authors.lastname: Ahn
mesh_terms: D000838:Anions / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007093:Imidazoles / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011145:Polyvinyls / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000838:Anions; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007093:Imidazoles; D011145:Polyvinyls; C550709:poly(1-vinyl-3-(2-sulfoethyl imidazolium betaine))