title: Angiotensin converting enzyme 2 gene expression increased compensatory for left ventricular remodeling in patients with end-stage heart failure.
abstract: It has been reported that angiotensin converting enzyme (ACE) 2, a homologue of ACE, has direct effects on cardiac function. However, the role of ACE2 in the development of human heart failure is not fully understood. We evaluated the expression of the ACE2 gene by means of real-time RT-PCR in myocardium from 14 patients with end-stage heart failure. The amount of ACE2 mRNA positively correlated with left ventricular (LV) end-diastolic diameter (r(2)=0.56, p<0.01) but did not significantly correlate with LV ejection fraction or plasma brain natriuretic peptide levels. In conclusion, our data show that the up-regulation of the ACE2 gene in the LV myocardium of patients with severe heart failure was associated with the degree of LV dilatation and may thereby constitute an important adaptive mechanism to retard the progression of adverse LV remodeling.
authors.affiliation: Department of Cardiology, Fujita Health University Hospital, Toyoake, Japan; 21st Century COE Program, Development Center for Targeted and Minimally Invasive Diagnosis and Treatment, Fujita Health University, Toyoake, Japan.
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Ohtsuki
authors.affiliation: Department of Cardiology, Fujita Health University Hospital, Toyoake, Japan.
authors.forename: Shin-Ichiro
authors.initials: SI
authors.lastname: Morimoto
authors.affiliation: Banbuntanehotokukai Hospital, Fujita Health University, Nagoya, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Izawa
authors.affiliation: Charing Cross Hospital, Imperial College NHS Trust, London, UK.
authors.forename: Tevfik F
authors.initials: TF
authors.lastname: Ismail
authors.affiliation: Department of Pathology, National Cardiovascular Center, Osaka, Japan.
authors.forename: Hatsue
authors.initials: H
authors.lastname: Ishibashi-Ueda
authors.affiliation: Department of Cardiology, Fujita Health University Hospital, Toyoake, Japan.
authors.forename: Yasuchika
authors.initials: Y
authors.lastname: Kato
authors.affiliation: Cardiovascular Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.
authors.forename: Taiko
authors.initials: T
authors.lastname: Horii
authors.affiliation: Hayama Heart Center, Kanagawa, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Isomura
authors.affiliation: The Cardiovascular Institute Hospital, Tokyo, Japan.
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Suma
authors.affiliation: Banbuntanehotokukai Hospital, Fujita Health University, Nagoya, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Nomura
authors.affiliation: Department of Cardiology, Fujita Health University Hospital, Toyoake, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hishida
authors.affiliation: 21st Century COE Program, Development Center for Targeted and Minimally Invasive Diagnosis and Treatment, Fujita Health University, Toyoake, Japan; Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kurahashi
authors.affiliation: Department of Cardiology, Fujita Health University Hospital, Toyoake, Japan. Electronic address: ozakiyuk@fujita-hu.ac.jp.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ozaki
mesh_terms: D000328:Adult; D000368:Aged; D000085962:Angiotensin-Converting Enzyme 2; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D006333:Heart Failure / Q000175:diagnosis / Q000201:enzymology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000201:enzymology / Q000473:pathology; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis*; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D015415:Biomarkers; D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2