Blimp-1 is a tumor suppressor gene in lymphoid malignancies.
B lymphocyte-induced maturation protein (Blimp-1) is a transcriptional factor, which controls the terminal differentiation of mature B cells to plasma cells. Blimp-1 is also called positive regulatory domain I-binding factor-1 (PRDI-BF1) or PR (PRDI-BF1-RIZ) domain zinc finger protein 1 (PRDM1). Furthermore, Blimp-1 is located in chromosome 6q21-22.1, a region frequently deleted in several tumors including lymphoid malignancies and has been supposed to be a candidate of tumor suppressor gene. Recently, mutational inactivation of Blimp-1 has been identified in a subset of diffuse large B-cell lymphomas of the activated B-cell type. In addition, an important role for Blimp-1 in maintaining the homeostasis of effector T cells is emerging and high expression of Blimp-1beta, a splicing variant of Blimp-1, have been presumed to be associated with poor prognosis in T cell lymphoma although this aspect of the gene needs further investigation. For this reason, we focused on the tumor suppressor function of Blimp-1 on not only B but also T cell malignancies in this review.
Hangaishi
Akira
A
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Kurokawa
Mineo
M
D001402:B-Lymphocytes / Q000502:physiology; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000503:physiopathology; D016399:Lymphoma, T-Cell / Q000235:genetics* / Q000503:physiopathology; D000074462:Positive Regulatory Domain I-Binding Factor 1; D012097:Repressor Proteins / Q000235:genetics*; D013601:T-Lymphocytes / Q000502:physiology
D012097:Repressor Proteins; C087042:PRDM1 protein, human; D000074462:Positive Regulatory Domain I-Binding Factor 1