title: Quality of life after adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled study.
abstract: BACKGROUND
  Adjuvant therapies for pancreatic and periampullary cancer reportedly achieve only a marginal survival benefit. In this randomized controlled trial, 120 patients with resected pancreatic or periampullary cancer received either adjuvant celiac axis infusion chemotherapy combined with radiotherapy (CAI/RT) or no adjuvant treatment. The objective of the study was to compare the quality of life (QoL) in patients who received CAI/RT after pancreatoduodenectomy with the QoL in patients who did not receive adjuvant treatment.
  
  
  METHODS
  During and after CAI/RT, QoL was assessed using the European Organization for Research and Treatment of Cancer QoL Questionnaire C30 every 3 months during the first 24 months after randomization.
  
  
  RESULTS
  Eighty-six percent of patients (n = 103) completed 1 or more questionnaires. In total, 355 questionnaires were completed. The results indicated that CAI/RT did not impair physical, emotional, or social functioning. During and after CAI/RT, patients had significantly less pain (P = .02) and less nausea and vomiting (P = .01). Overall QoL (global functioning) tended to be better (P = .08) after CAI/RT.
  
  
  CONCLUSIONS
  Over a period of 24 months, CAI/RT improved QoL compared with observation alone in patients with resected pancreatic and periampullary cancer. This beneficial effect of CAI/RT was most prominent in the latter half of the follow-up.
authors.affiliation: Department of Surgery, Erasmus Medical Centre, 3015 CE Rotterdam, The Netherlands.
authors.forename: Marjolein J M
authors.initials: MJ
authors.lastname: Morak
authors.forename: Chulja J
authors.initials: CJ
authors.lastname: Pek
authors.forename: Erwin J O
authors.initials: EJ
authors.lastname: Kompanje
authors.forename: Wim C J
authors.initials: WC
authors.lastname: Hop
authors.forename: Geert
authors.initials: G
authors.lastname: Kazemier
authors.forename: Casper H J
authors.initials: CH
authors.lastname: van Eijck
mesh_terms: D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000523:psychology* / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant; D013997:Time Factors; D016896:Treatment Outcome