Expression of CXCR6 on CD8(+) T cells was up-regulated in allograft rejection.
CXCL16/SR-PSOX is a novel transmembrane-type chemokine, which was also identified as a novel scavenger receptor for oxidized low density lipoprotein. Its receptor CXCR6 expresses on activated CD8(+) T cells, type 1-polarized CD4(+), and constitutively expresses on NKT cells. Moreover, it has been shown that CXCL16 accumulated activated CD8(+) T cells to sites of inflammation. To date, the effect of CXCL16 (SR-PSOX)/CXCR6 on CD8(+) T cells and its role in allograft rejection/acceptance are not well understood. In the current study, we show that rejected allografts showed higher expressions of CXCR6 and CXCL16. More importantly, expression of CXCR6 on CD8(+) T cells was also up-regulated by rejection. However, the blockade of CXCL16(SR-PSOX)/CXCR6 interaction could not inhibit cytotoxic activity of CD8(+) T cells, and therefore, could not prolong the cardiac graft survival time.
Jiang
Xiaofeng
X
Department of Surgery, the Fourth Affiliated Hospital, China Medical University, Shengyang, 110032, China. jiang_xiaofeng@hotmail.com
Sun
Wenyu
W
Zhu
Lei
L
Guo
Dawei
D
Jiang
Honglei
H
Ma
Dongyan
D
Jin
Junzhe
J
Zhao
Yu
Y
Liang
Jian
J
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D006084:Graft Rejection / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D006085:Graft Survival / Q000187:drug effects; D016027:Heart Transplantation; D016130:Immunophenotyping; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D054387:Receptors, CXCR / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D000075744:Receptors, CXCR6; D013154:Spleen / Q000473:pathology; D014184:Transplantation, Homologous; D015854:Up-Regulation
D000911:Antibodies, Monoclonal; C482906:Cxcr6 protein, mouse; D054387:Receptors, CXCR; D000075744:Receptors, CXCR6