Discovery of indolone acetamides as novel SV2A ligands with improved potency toward seizure suppression.
Frycia
Anne
A
Department of Chemistry, UCB Pharma S.A., Chemin du Foriest, 1420 Braine l'Alleud, Belgium.
Starck
Jean-Philippe
JP
Jadot
Sophie
S
Lallemand
Bénédicte
B
Leclercq
Karine
K
Lo Brutto
Patrick
P
Matagne
Alain
A
Verbois
Valérie
V
Mercier
Joël
J
Kenda
Benoit
B
D000081:Acetamides / Q000737:chemistry* / Q000493:pharmacokinetics; D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry* / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D007211:Indoles / Q000737:chemistry*; D000077287:Levetiracetam; D008024:Ligands; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010889:Piracetam / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D011760:Pyrrolidinones / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000188:drug therapy*; D013572:Synaptic Vesicles / Q000378:metabolism
D000081:Acetamides; D000927:Anticonvulsants; D007211:Indoles; D008024:Ligands; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D011760:Pyrrolidinones; C518915:Seletracetam; C489614:Sv2a protein, mouse; D000077287:Levetiracetam; C482793:brivaracetam; D010889:Piracetam