title: Multicomponent reaction discovery: three-component synthesis of spirooxindoles.
abstract: The Lewis acid-catalyzed, three-component reaction of isatin and two 1,3-dicarbonyl compounds is reported. Reactions proceed with high efficiency under mild reaction conditions and with good functional group tolerance to afford spirooxindole pyranochromenedione derivatives.
authors.affiliation: Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, Boston, Massachusetts 02215, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Liang
authors.forename: Srinivas
authors.initials: S
authors.lastname: Kalidindi
authors.forename: John A
authors.initials: JA
authors.lastname: Porco
authors.forename: Corey R J
authors.initials: CR
authors.lastname: Stephenson
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007211:Indoles; D013141:Spiro Compounds