title: Mesenchymal stem cells and bovine bone mineral in sinus lift procedures--an experimental study in sheep.
abstract: BACKGROUND
  New reconstructive and less invasive methods have been searched to optimize bone formation and osseointegration of dental implants in maxillary sinus augmentation.
  
  
  OBJECTIVE
  The aim of the presented ovine split-mouth study was to compare bovine bone mineral (BBM) alone and in combination with mesenchymal stem cells (MSCs) regarding their potential in sinus augmentation.
  
  
  METHODS
  Bilateral sinus floor augmentations were performed in six adult sheep. BBM and MSCs were placed into the test side and only BBM in the contra-lateral control side of each sheep. Animals were sacrificed after 8 and 16 weeks. Augmentation sites were analyzed by computed tomography, histology, and histomorphometry.
  
  
  RESULTS
  The initial volumes of both sides were similar and did not change significantly with time. A tight connection between the particles of BBM and the new bone was observed histologically. Bone formation was significantly (p = 0.027) faster by 49% in the test sides.
  
  
  CONCLUSIONS
  The combination of BBM and MSCs accelerated new bone formation in this model of maxillary sinus augmentation. This could allow early placement of implants.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Albert-Ludwigs-University, Freiburg, Germany. sebastian.sauerbier@uniklinik-freiburg.de
authors.forename: Sebastian
authors.initials: S
authors.lastname: Sauerbier
authors.forename: Kerstin
authors.initials: K
authors.lastname: Stubbe
authors.forename: Michele
authors.initials: M
authors.lastname: Maglione
authors.forename: Jörg
authors.initials: J
authors.lastname: Haberstroh
authors.forename: Jens
authors.initials: J
authors.lastname: Kuschnierz
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Oshima
authors.forename: Samuel Porfirio
authors.initials: SP
authors.lastname: Xavier
authors.forename: Leo
authors.initials: L
authors.lastname: Brunnberg
authors.forename: Rainer
authors.initials: R
authors.lastname: Schmelzeisen
authors.forename: Ralf
authors.initials: R
authors.lastname: Gutwald
mesh_terms: D000818:Animals; D001842:Bone and Bones; D002417:Cattle; D002448:Cell Adhesion; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D008903:Minerals; D010256:Paranasal Sinuses / Q000601:surgery*; D012756:Sheep
chemical_list: D008903:Minerals