Relationship of synovial tumor necrosis factor alpha and interleukin 6 to temporomandibular disorder.
OBJECTIVE
The purpose of this study was to elucidate the relationship of tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) to temporomandibular disorder with clinical symptoms such as pain, joint sounds, and mouth opening limitation by analysis of the level of these molecules in the synovial fluid.


METHODS
Twenty-four patients with chief complaints of pain, mouth opening limitation, and clicking sounds were selected as the experimental group and compared with 5 healthy subjects. After joint lavage with arthrocentesis, diluted synovial fluid was collected and enzyme-linked immunosorbent assay was done for analysis of TNF-alpha and IL-6 in 24 experimental patients and 5 healthy subjects.


RESULTS
The synovial levels of TNF-alpha and IL-6 were elevated in the experimental group compared with the healthy control group, but no significant correlation was established. The synovial levels of TNF-alpha and IL-6 were elevated in the acute pain group compared with the chronic pain group, but no significant correlation was established.


CONCLUSIONS
In our analysis of 2 proinflammatory cytokines, TNF-alpha and IL-6, in the synovial fluid of temporomandibular disorder patients with symptoms of pain, mouth opening limitation, and clicking, both were elevated without statistical significance.
Lee
Jeong Keun
JK
Department of Dentistry, Ajou University School of Medicine, Suwon, South Korea. arcady@ajou.ac.kr
Cho
Young Sook
YS
Song
Seung Il
SI
D000208:Acute Disease; D015415:Biomarkers / Q000032:analysis; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005157:Facial Pain / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis*; D019152:Paracentesis; D016059:Range of Motion, Articular / Q000502:physiology; D013016:Sound; D013582:Synovial Fluid / Q000276:immunology*; D013705:Temporomandibular Joint Disorders / Q000276:immunology* / Q000503:physiopathology; D007507:Therapeutic Irrigation; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D015415:Biomarkers; D018836:Inflammation Mediators; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha