Germatranyl substituted organotin (IV) carboxylates: synthesis spectroscopic characterization and biological activities.
Eight new organotin (IV) derivatives of general formula [N(CH2CH2O)3GeCH(R1)CH2COO](4-n)SnR(2)n, where n= 2, R(2) = C2H5 (1-5); R(1) = CH3 (1); C6H5 (2); p-CH3C6H4 (3); p-FC6H4(4); p-CH3OC6H4 (5) and n = 3, R(2) = CH2C6H5 (6-8), R(1) = CH3 (6); C6H5 (7); p-CH3C6H4 (8) have been synthesized by the reaction of di- or tri-organotin chloride with the corresponding germatranyl (substituted) propionic acid in the appropriate mole ratios using triethylamine as a base. The synthesized compounds were characterized by various spectroscopic techniques such as IR, multi-nuclear (1H, 13C, 119Sn) NMR, 119mSn Mössbauer, along with elemental analyses. They were also screened for in vitro anti-leishmanial activity against promastigotes of leishmania donovani and found some encouraging results.
Salma
U
U
Department of Chemistry, Allama Iqbal Open University Islamabad 44000, Pakistan.
Imtiaz-ud-Din
Mazhar
M
M
Khan
Khalid Mohammed
KM
D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000737:chemistry*; D018320:Leishmania major / Q000187:drug effects; D008024:Ligands; D009947:Organotin Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013057:Spectrum Analysis
D000981:Antiprotozoal Agents; D002264:Carboxylic Acids; D008024:Ligands; D009947:Organotin Compounds