High serum level of neopterin is a risk factor of patients with heart failure.
Serum neopterin concentration was measured in 198 patients with chronic heart failure (CHF) and 62 control subjects by ELISA. Patients were prospectively followed during a median follow-up period of 745 days with end points of cardiac death or re-hospitalization due to progressive heart failure. Serum concentration of neopterin increased with advancing New York Heart Association (NYHA) functional class (P<0.001). High neopterin group had a significantly higher incidence of cardiac events than low neopterin group (P<0.0001). In the multivariate Cox analysis, serum neopterin concentration was an independent risk factor for cardiac events (hazard ratio 1.70, 95%CI 1.16-2.50, P=0.0068). Serum neopterin concentration is a novel prognostic marker for CHF.
Sasaki
Toshiki
T
First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.
Takeishi
Yasuchika
Y
Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Japan. Electronic address: takeishi@fmu.ac.jp.
Suzuki
Satoshi
S
First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.
Niizeki
Takeshi
T
First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.
Kitahara
Tatsuro
T
First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.
Katoh
Shigehiko
S
First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.
Ishino
Mitsunori
M
First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.
Shishido
Tetsuro
T
First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.
Watanabe
Tetsu
T
First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.
Kubota
Isao
I
First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000096:biosynthesis / Q000097:blood*; D011446:Prospective Studies; D012307:Risk Factors
D015415:Biomarkers; D019798:Neopterin