title: Midregional pro-A-type natriuretic peptide for the evaluation of exercise intolerance.
abstract: The aim of this study was to determine the accuracy of midregional pro-A-type natriuretic peptide (MR-proANP) for the identification of a cardiocirculatory exercise limitation (CL) as assessed by cardiopulmonary exercise testing (CPET) and to compare it to B-type natriuretic peptide (BNP). Among 94 patients with CPET data fulfilling criteria for appropriate effort and sufficient diagnostic certainty, 27 (29%) had CL. The areas under the receiver-operator-characteristic curve for MR-proANP and BNP to identify CL were 0.84 and 0.79 respectively (p=0.17). In conclusion, MR-proANP had a comparable accuracy to BNP for the identification of CL and might be a valuable assistance for the differentiation of exercise intolerance.
authors.affiliation: Baker IDI Heart and Diabetes Institute, Melbourne, Australia. Electronic address: micha.maeder@bluewin.ch.
authors.forename: Micha T
authors.initials: MT
authors.lastname: Maeder
authors.affiliation: Division of Respiratory Medicine, Kantonsspital St. Gallen, Switzerland.
authors.forename: Martin H
authors.initials: MH
authors.lastname: Brutsche
authors.affiliation: Department of Internal Medicine, University Hospital Basel, Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Christ
authors.affiliation: Department of Internal Medicine, University Hospital Basel, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Staub
authors.affiliation: Department of Internal Medicine, University Hospital Basel, Switzerland.
authors.forename: Markus
authors.initials: M
authors.lastname: Noveanu
authors.affiliation: Department of Internal Medicine, University Hospital Basel, Switzerland.
authors.forename: Tobias
authors.initials: T
authors.lastname: Breidthardt
authors.affiliation: Department of Internal Medicine, University Hospital Basel, Switzerland.
authors.forename: Nora
authors.initials: N
authors.lastname: Schaub
authors.affiliation: Department of Internal Medicine, University Hospital Basel, Switzerland.
authors.forename: Mihael
authors.initials: M
authors.lastname: Potocki
authors.affiliation: Department of Internal Medicine, University Hospital Basel, Switzerland.
authors.forename: Tobias
authors.initials: T
authors.lastname: Reichlin
authors.affiliation: Department of Research, B.R.A.H.M.S. AG, Biotechnology Center, Henningsdorf/Berlin, Germany.
authors.forename: Nils G
authors.initials: NG
authors.lastname: Morgenthaler
authors.affiliation: Department of Research, B.R.A.H.M.S. AG, Biotechnology Center, Henningsdorf/Berlin, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Bergmann
authors.affiliation: Department of Internal Medicine, University Hospital Basel, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Mueller
mesh_terms: D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005080:Exercise Test / Q000592:standards*; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood
chemical_list: D015415:Biomarkers; C552580:midregional pro-atrial natriuretic peptide, human; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor