[Hemophagocytosis associated with cytomegalovirus infection and azathioprine treatment for inflammatory bowel disease].
Haemophagocytic lymphohistiocytosis (HLH) is a rare syndrome characterized by fever and cytopenia due to phagocytosis of erythrocytes, leukocytes, platelets, and their precursors in bone marrow and other tissues. HLH can be primary (genetic) or associated with neoplastic diseases, autoimmune diseases or infections. HLH is a rare syndrome but can cause very severe illness, and if unrecognized/untreated the condition is associated with a high mortality. We present two cases of cytomegalovirus infection-associated HLH in patients with inflammatory bowel disease during azathioprin treatment.
Petrache
Anca
A
Medicinsk Afdeling, Vejle Sygehus, DK-7100 Vejle, Denmark. ancapetrache@yahoo.dk
Møller
Michael Boe
MB
Frederiksen
Henrik
H
D000328:Adult; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000150:complications / Q000188:drug therapy*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000209:etiology* / Q000821:virology; D008297:Male
D007166:Immunosuppressive Agents; D001379:Azathioprine