Interassay reproducibility of myocardial perfusion gated SPECT in patients with atrial fibrillation.
OBJECTIVE
The aim of this study was to assess interassay reproducibility of myocardial perfusion gated-SPECT for calculation of end-diastolic volume (EDV), end-systolic volume (ESV), and left ventricular ejection fraction (LVEF) in patients with atrial fibrillation (AF).


METHODS
One hundred and fifteen consecutive patients with AF from three participating hospitals (mean age 68.9 years, 39 women) were included in the study. All patients underwent two image gated acquisitions at rest with a 30 minute interval between them. Quantitative data were obtained using the QGS and ECT software algorithms.


RESULTS
Heart rate was similar in both studies: 74.94 +/- 15.2 vs 73.03 +/- 15.57. QGS yielded an LVEF of 54.4%/53.8%, an EDV of 100 mL/101.5 mL, and an ESV of 51 mL/52.3 mL; and ECT showed an LVEF of 63.6%/62.9%, an EDV of 125.8 mL/127.4 mL and ESV of 54.1 mL/56.3 mL. Correlation between the two acquisitions was high (>0.948) for both methods for LVEF, EDV and ESV. Regression and Bland-Altman graphics showed a good agreement between all parameters. Interassay variation coefficients for each method (QGS/ECT) were 5.29% vs 4.83% for LVEF, 4.94% vs 5.17% for EDV, and 9.94% vs 12.78% for ESV.


CONCLUSIONS
Interassay reproducibility of LVEF and EDV with gated-SPECT in patients with AF is good, whereas for ESV it is suboptimal, particularly when ESV is small.
Aguadé-Bruix
Santiago
S
Department of Nuclear Medicine, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, 08035 Barcelona, Spain. saguade@vhebron.net
Romero-Farina
Guillermo
G
Cuberas-Borros
Gemma
G
Milà-Lopez
Marta
M
Pubul-Núñez
Virginia
V
Siurana-Escuer
Rosa
R
García-Dorado
David
D
Candell-Riera
Jaume
J
D000368:Aged; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging* / Q000503:physiopathology; D055426:Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D055414:Myocardial Perfusion Imaging; D015203:Reproducibility of Results; D013318:Stroke Volume