Circadian proteins and genotoxic stress response.
The circadian clock is an evolutionarily conserved time-keeping system that coordinates the physiology of the organism with daily changes in the environment. A growing body of evidence gradually leads to the conception that virtually all aspects of the biochemical, physiological, and behavioral functions of the animal are linked to circadian regulation. Moreover, proper synchronization of various processes through the activity of circadian components is important for the well-being of many organisms, including humans. The focus of this review is the circadian control of an organism's response to genotoxic stress, which is a major contributor to life-threatening human pathologies such as cancer and cardiovascular disease.
Antoch
Marina P
MP
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm & Carlton St, Buffalo, NY 14263, USA. marina.antoch@roswellpark.org
Kondratov
Roman V
RV
D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism*; D002940:Circadian Rhythm; D056925:Circadian Rhythm Signaling Peptides and Proteins / Q000378:metabolism*; D004249:DNA Damage; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*
D056925:Circadian Rhythm Signaling Peptides and Proteins; D009363:Neoplasm Proteins