Agonist-selective signaling of G protein-coupled receptor: mechanisms and implications.
Agonist-selective signaling or ligand-biased signaling of G protein-coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current review summarizes the observations of agonist-selective signaling of various GPCRs, indicating the significance of agonist-selective signaling in biological processes. In addition, current review also provides an overview on how agonist-selective signaling is initiated. Especially, the relationship between GPCR-G protein interaction and GPCR-beta-arrestin interaction is discussed in depth.
Zheng
Hui
H
Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455-0217, USA. zhen0091@umn.edu
Loh
Horace H
HH
Law
Ping-Yee
PY
D000818:Animals; D019390:Arrestins / Q000502:physiology; D001665:Binding Sites; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D021962:Membrane Microdomains / Q000502:physiology; D010766:Phosphorylation; D043562:Receptors, G-Protein-Coupled / Q000819:agonists* / Q000502:physiology*; D017450:Receptors, Opioid, mu / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D000071557:beta-Arrestins
D019390:Arrestins; D043562:Receptors, G-Protein-Coupled; D017450:Receptors, Opioid, mu; D000071557:beta-Arrestins; D048049:Extracellular Signal-Regulated MAP Kinases; D019204:GTP-Binding Proteins