Inhibitory effects of taurine and oat fiber on intestinal endotoxin release in rats.
Numerous studies have demonstrated that endotoxin plays an important role in the development and progression of hepatic cirrhosis. However, there is no effective remedy for the prevention and treatment of intestinal endotoxemia. Taurine has been reported to have beneficial effects on endotoxemia. Oats have been shown to absorb intestinal toxins and increase excretion of intestinal toxins. The present study was to investigate whether a combination of taurine and oat has an additive inhibitory effect on endotoxin release in a rat liver ischemia/reperfusion model. Our results showed that the combination of taurine (300mgkg(-1)d(-1)) and oat fiber (15gkg(-1)d(-1)) significantly reduced endotoxin levels in the portal vein by 36.3% when compared to the control group (0.168+/-0.035Eu/ml in the treatment group vs 0.264+/-0.058Eu/ml in the control group, P<0.01). The treatment of taurine (300mgkg(-1)d(-1)) and oat fiber (15gkg(-1)d(-1)) induced 21.5% and 18.4% reduction in endotoxin levels, respectively, when compared to the control group (P<0.05). We conclude that the combination of taurine and oat fiber achieved an additive inhibitory effect on intestinal endotoxin release, which might be an effective approach for the treatment of intestinal endotoxemia.
Wan
Xu-ying
XY
Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China.
Luo
Ming
M
Li
Xiao-dong
XD
He
Ping
P
Wu
Meng-Chao
MC
D000818:Animals; D018554:Avena; D004043:Dietary Fiber / Q000494:pharmacology*; D004195:Disease Models, Animal; D004731:Endotoxins / Q000097:blood*; D007422:Intestines / Q000382:microbiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013654:Taurine / Q000494:pharmacology*
D004043:Dietary Fiber; D004731:Endotoxins; D013654:Taurine