title: Total antioxidant status and oxidative DNA damage in a South Indian population of essential hypertensives.
abstract: To investigate the total antioxidant status (TAS) and the extent of oxidative DNA damage in total lymphocytes and their relation with essential hypertension. A total of 130 South Indian subjects aged 30-65 were recruited for the study. Of these hypertensive subjects investigated, 30 were newly diagnosed and were not on any antihypertensive drugs, but had systolic blood pressure (BP) ranging between 140 and 160 mm Hg and diastolic BP between 95 and 100 mm Hg; 50 hypertensive patients who were already on drug therapy for 1 year and 50 were normotensive controls with BP < or =120/80 mm Hg. DNA damage was significantly increased in hypertensive patients (both newly diagnosed and who were already on drug therapy) compared with control group. The major increase in DNA damage was observed in newly diagnosed hypertensive patients compared with hypertensive patients who were already on drug therapy. There was a significant decrease in plasma TAS value in essential hypertensive groups as compared to normotensive controls. Lymphocyte DNA damage was independently correlated with only TAS. Lymphocyte DNA damage was increased in hypertensive patients. The major increase in lymphocyte DNA damage was observed in newly diagnosed hypertensive patients compared with hypertensive patients who already on drug therapy. Decreased TAS levels, which reflect to increased oxidative stress, may be the reason of increased total lymphocyte DNA damage in South Indian hypertensive patients.
authors.affiliation: Department of Biochemistry, International Centre for Cardio Thoracic and Vascular Diseases, A Unit of Frontier Lifeline, Dr KM Cherian Heart Foundation, Chennai, Tamil Nadu, India. subash_15_p@yahoo.co.in
authors.forename: P
authors.initials: P
authors.lastname: Subash
authors.forename: K
authors.initials: K
authors.lastname: Premagurumurthy
authors.forename: A
authors.initials: A
authors.lastname: Sarasabharathi
authors.forename: K M
authors.initials: KM
authors.lastname: Cherian
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D004249:DNA Damage; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D007194:India / Q000453:epidemiology; D008214:Lymphocytes / Q000737:chemistry / Q000378:metabolism; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress
chemical_list: D000959:Antihypertensive Agents