AMP-activated protein kinase: a stress-responsive kinase with implications for cardiovascular disease.
AMP-activated protein kinase (AMPK) was initially viewed as energy sensor and activated by increased intracellular concentrations of AMP following nutrient deprivation. Physiological or pathological stimuli that deplete cellular energy activate AMPK that coordinates a cellular program that limits further ATP depletion and promotes compensatory changes that maintain cellular ATP levels. Recent studies revealed novel roles of AMPK independent of energy status, thereby increasing our understanding of multi-functional roles of AMPK in cells important in pathogenesis of cardiovascular diseases. This enzyme represents an attractive therapeutic target for vascular disease treatment in the future.
Li
Chunying
C
Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue N, S3-855, Worcester, MA 01655, USA.
Keaney
John F
JF
D055372:AMP-Activated Protein Kinases / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology; D013312:Stress, Physiological / Q000502:physiology*
D055372:AMP-Activated Protein Kinases