[A case of advanced esophageal cancer with para-aortic lymph node metastasis with complete response (CR) to combination chemotherapy including nedaplatin].
The patient was a 55-year-old male, who was diagnosed to have a middle thoracic esophageal squamous cell carcinoma with para-aortic lymph node metastasis. The clinical stage diagnosis was T3N4M1, stage IVb, non-resectable esophageal SCC. Systemic chemotherapy with low-dose nedaplatin/5-FU treatment was started as the initial treatment. After three courses, para-aortic lymph node metastasis was not found by CT scan, and we added radiation therapy. After radiation therapy by 45 Gy, primary lesion and mediasternal lymph node metastasis were not shown by endoscopy and CT scan. We detected an increase of tumor marker after the observation for six months without any treatment, and then we started docetaxel/nedaplatin treatment as secondary chemotherapy. After ten courses, the tumor marker was decreased, and the patient is still in a stable disease state. We concluded that FGP therapy and DGP therapy were a very effective treatment for advanced esophageal SCC.
Noda
Satoru
S
Department of Surgical Oncology, Osaka City University Graduate School of Medicine.
Kubo
Naoshi
N
Tanaka
Hiroaki
H
Muguruma
Kazuya
K
Yashiro
Masakazu
M
Yamada
Nobuya
N
Maeda
Kiyoshi
K
Sawada
Tetsuji
T
Ohira
Masaichi
M
Ishikawa
Tetsuro
T
Hirakawa
Kosei
K
D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C053989:nedaplatin