title: AKT1 Gene Polymorphisms and Obstetric Complications in the Patients with Schizophrenia.
abstract: OBJECTIVE
  We performed a genetic association study with schizophrenic patients to investigate whether the V-akt murine thymoma viral oncogene homolog 1 (AKT1) gene plays a role in obstetric complications.
  
  
  METHODS
  One-hundred-eighty patients with schizophrenia (male, 113; female, 67) were included. All patients fulfilled DSM-IV criteria for schizophrenia. Obstetric complications were measured by the Lewis scale. Prenatal and perinatal information was retrospectively collected from the patients' mothers. We selected six single nucleotide polymorphisms (SNPs) for the AKT1 gene: SNP1 (rs3803300), SNP2 (rs1130214), SNP3 (rs3730358), SNP4 (rs 1130233), SNP5 (rs2494732), and SNPA (rs2498804). The genotype data were analyzed for an association with the Lewis total score in terms of allele, genotype, and haplotype distribution.
  
  
  RESULTS
  The mean total Lewis scores were 1.30+/-1.61 for males and 1.54+/-1.87 for females. Higher total score tended to be correlated with an earlier age of onset of schizophrenia in females. In the total sample, no SNP was associated with obstetric complications. However, the additional analyses for male and female subgroups found a significant association between SNPA and SNP4 and Lewis score in females (p=0.02 for SNPA, p=0.04 for SNP4). The SNP5-SNPA haplotype showed a positive association with obstetric complications (p=0.03) in the female patient group.
  
  
  CONCLUSIONS
  We found an association between SNPs in the AKT1 gene and total Lewis score measuring obstetric complications in female patients with schizophrenia. Because these findings did not survive a correction for multiple testing, the significance should be interpreted carefully and replication studies are required.
authors.affiliation: Department of Psychiatry, Eulji University School of Medicine, Daegeon, Korea.
authors.forename: Eun-Jeong
authors.initials: EJ
authors.lastname: Joo
authors.forename: Kyu-Young
authors.initials: KY
authors.lastname: Lee
authors.forename: Seong-Hoon
authors.initials: SH
authors.lastname: Jeong
authors.forename: Myoung-Sun
authors.initials: MS
authors.lastname: Roh
authors.forename: Se Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Ahn
authors.forename: Yong Sik
authors.initials: YS
authors.lastname: Kim