Science to practice: what does MR oxygenation imaging tell us about human breast cancer hypoxia?
The paradoxical relationship between blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging and breast cancer hypoxia challenges our current understanding of what we believe is happening to erythrocytes in tumors. The ability of air breathing R2* measurements to reflect tissue hypoxia appears to be tumor type-specific, which should prompt further exploration of this image contrast mechanism in both human and animal tumors.
Padhani
Anwar
A
Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, Middlesex HA6 2RN UK. anwar.padhani@stricklandscanner.org.uk
D000818:Animals; D001943:Breast Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology; D004912:Erythrocytes / Q000502:physiology*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D010641:Phenotype; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed / Q000379:methods*
D019275:Radiopharmaceuticals; D010100:Oxygen