[LEDGF/p75: a novel target for anti-HIV therapy and advances in the study of its related inhibitors].
LEDGF/p75 is a newly found cell cofactor, which plays an essential role in the integration of HIV-1 cDNA into host chromosomes. LEDGF/p75 tethers HIV integrase to chromatin, protects it from degradation, and strongly influences the genome-wide pattern of HIV integration. Depleting the protein from cells or over-expressing the integrase-binding domain of LEDGF/p75 blocks viral replication. The essential role of LEDGF/p75 in HIV-1 replication makes it a new target for anti-HIV-1 drug development. This article reviews the function of LEDGF/p75, LEDGF/p75-integrase interaction and LEDGF/p75 inhibitors.
Chen
Wen-Min
WM
Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012, China.
Liu
Xin-Yong
XY
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology*; D019427:HIV Integrase / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D011485:Protein Binding
D019380:Anti-HIV Agents; D036341:Intercellular Signaling Peptides and Proteins; C119380:lens epithelium-derived growth factor; D019427:HIV Integrase