Redox regulation of stem cell mobilization.
A growing body of evidence supports the role of redox signaling in the mechanisms of hematopoietic stem cell mobilization and homing. Cytokines and adhesion molecules control stem cell mobilization through a redox-regulated process. The FoxO-SirT network appears to be intimately involved in redox-regulated stem cell homeostasis, whereas the process of stem cell differentiation is regulated by redox effector factor-1 (Ref-1) protein. Lack of oxygen (hypoxia), specifically controlled hypoxia, can stimulate the growth of the stem cells in their niche, and hypoxia-inducible factor (HIF)-1alpha appears to play a significant role in their maintenance and homing mechanism.
Lekli
Istvan
I
Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030-1110, USA.
Gurusamy
Narasimman
N
Ray
Diptarka
D
Tosaki
Arpad
A
Das
Dipak K
DK
D000818:Animals; D002454:Cell Differentiation; D016207:Cytokines / Q000502:physiology; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000502:physiology; D051858:Forkhead Transcription Factors / Q000502:physiology; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D010084:Oxidation-Reduction; D015398:Signal Transduction / Q000502:physiology; D037761:Sirtuins / Q000502:physiology
D016207:Cytokines; D051858:Forkhead Transcription Factors; D037761:Sirtuins; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase