[Impact of malaria during pregnancy in the Amazon region].
OBJECTIVE
To estimate the impact of malaria on the course of pregnancy in women from the Amazon region and to investigate possible risk factors in this population.


METHODS
This cross-sectional study is part of a larger project to study malaria and pregnancy in the Amazon region. Pregnant women with malaria receiving care at the Amazon Tropical Medicine Foundation (Fundação de Medicina Tropical do Amazonas) who answered a structured interview were included in the study. Socioeconomic, behavioral and clinical data were collected in the first consultation relating to each new malaria attack. All the women were followed-up throughout their pregnancy. The following risk factors for impact of malaria on the course of pregnancy were considered: being younger than 20 years of age, first pregnancy, first malaria infection, and type of infecting plasmodium species.


RESULTS
Five hundred and thirty-five malaria episodes were evaluated in 417 pregnant women, with 20.56% being caused by P. falciparum, 78.69% by P. vivax and 0.75% by the association of both parasites. Changes in the course of pregnancy were very frequent (26.2%). Threat of abortion was observed in 49 cases (25.5%), abortion in two (1.0%), threat of premature birth in 74 (25.1%), and premature birth in three (1.0%). First pregnancy and age < 20 years were significantly associated with threat of premature birth and abortion.


CONCLUSIONS
Changes in the course of pregnancy were very frequent during acute malaria attacks, despite the low frequency of abortion. The present results do not highlight specific risk factors, suggesting that any pregnant woman may be at risk for the threat of abortion or for abortion during acute malaria attacks.
Chagas
Eda Cristina da Silva
EC
Fundação de Medicina Tropical do Amazonas, Manaus (AM), Brasil. eda-chagas@uol.com.br
do Nascimento
Cristiana Teixeira
CT
de Santana Filho
Franklin Simões
FS
Bôtto-Menezes
Camila Helena
CH
Martinez-Espinosa
Flor Ernestina
FE
D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008288:Malaria / Q000453:epidemiology*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000453:epidemiology*; D012307:Risk Factors; D055815:Young Adult