[Intermittent hepatic arterial infusion with systemic chemotherapy for metastatic colorectal cancer].
We report 5 cases of metastatic colorectal cancer with intermittent hepatic arterial infusion (HAI) and systemic chemotherapy (CPT-11, biweekly) in 2006-2008. Two patients with poor performance status were for systemic chemotherapy, and 3 patients were initiated as third-line treatment or more. Among the 5 patients, 2 patients were recorded as PR, 2 patients were as SD, and 1 patient was as NE. Three patients are alive with a mean follow-up of 19 months. HAI is intended to have few side effects compared with the systemic chemotherapy, and the treatment methods for these cases were not indicated for any of standard chemotherapies. But HAI alone is considered as insufficient treatment for unresectable liver metastasis, because HAI cannot be proved to have an apparent survival benefit. It is possible that a combination of regional and systemic drug treatments will be more effective than systemic treatment alone for unresectable colorectal cancer.
Ide
Yoshihito
Y
Department of Surgery, Suita Municipal Hospital.
Mikami
Koji
K
Murata
Kohei
K
D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods; D007275:Injections, Intravenous; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008875:Middle Aged
D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D002166:Camptothecin