title: Synthesis and antibacterial activity of benzyl-[3-(benzylamino-methyl)-cyclohexylmethyl]-amine derivatives.
abstract: A series of benzyl-[3-(benzylamino-methyl)-cyclohexylmethyl]-amine derivatives with different substitution pattern on the aromatic ring have been prepared and evaluated for their antibacterial activity against Gram-positive and Gram-negative bacterial strains. Most of the compounds exhibit potent activity against Pseudomonas aeruginosa and Staphylococcus epidermidis while compounds 6l and 6m showed antibacterial activity against all the four bacterial strains with MIC values ranging from 0.002 to 0.016 microg/mL and no hemolytic activity up to 512 microg/mL in mammalian erythrocytes was observed.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110 007, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Kumar
authors.forename: Seema
authors.initials: S
authors.lastname: Joshi
authors.forename: Rajesh K
authors.initials: RK
authors.lastname: Rohilla
authors.forename: Nilanjan
authors.initials: N
authors.lastname: Roy
authors.forename: Diwan S
authors.initials: DS
authors.lastname: Rawat
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001596:Benzylamines / Q000138:chemical synthesis / Q000494:pharmacology; D003510:Cyclohexanes / Q000138:chemical synthesis / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects / Q000502:physiology*; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents; D001596:Benzylamines; D003510:Cyclohexanes