title: The main product of specialized tissues regulates cell life and may cause neoplastic transformation.
abstract: Many tissues and cells in vertebrates are highly specialized and devoted to a single function through the action of a single molecule, that we call the "main product" (MP) of the cell. The hypothesis here proposed is that these MPs control all aspects of the cell life, namely activity, division, differentiation and apoptosis. Evidences supporting this hypothesis are reported for the immune system, pancreatic beta-cells, melanocytes, connective tissues, thyroid cells, skin and erythroid cells. In all cases cell division and differentiation is promoted by a normal activity of the MP, while hyperactivity leads to cell apoptosis. Evidences are also provided that alterations of the activity of the MP may elicit pathological disorders; in particular mutations altering the structure of the MP may elicit tumoural transformation.
authors.affiliation: Dipartimento di Biologia Cellulare e Ambientale, Universita' di Perugia, Perugia, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Morpurgo
authors.forename: Bernard
authors.initials: B
authors.lastname: Fioretti
authors.forename: Luigi
authors.initials: L
authors.lastname: Catacuzzeno
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002468:Cell Physiological Phenomena / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D002477:Cells / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological