title: Successful prior treatment with dasatinib followed by stem cell transplantation in a patient with CML in blastic crisis with a BCR-ABL mutation.
abstract: We report a case of imatinib- and nilotinib-resistant Ph-positive chronic myeloid leukemia (CML) in blast crisis in which successful pretreatment with dasatinib with cord blood transplantation resulted in molecular remission. Before dasatinib therapy, the patient was found to have a F359V BCR-ABL mutation. He was treated with dasatinib for just 16, 19 days before allogeneic stem cell transplantation. This successful case indicates that reduction of tumor burden by second-generation tyrosine kinase inhibitors, in combination with stem cell transplantation, might be effective to treat CML, even in the advanced phase.
authors.affiliation: First Department of Internal Medicine (Division of Hematology), Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan. gotohm@wj8.so-net.ne.jp
authors.forename: Moritaka
authors.initials: M
authors.lastname: Gotoh
authors.forename: Tetsuzo
authors.initials: T
authors.lastname: Tauchi
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Yoshizawa
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kitahara
authors.forename: Toru
authors.initials: T
authors.lastname: Kiguchi
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Kimura
authors.forename: Kazuma
authors.initials: K
authors.lastname: Ohyashiki
mesh_terms: D001752:Blast Crisis / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D036101:Cord Blood Stem Cell Transplantation; D000069439:Dasatinib; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage*; D011743:Pyrimidines / Q000008:administration & dosage*; D013844:Thiazoles / Q000008:administration & dosage*
chemical_list: D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D013844:Thiazoles; D016044:Fusion Proteins, bcr-abl; D000069439:Dasatinib