[Bartonella henselae, an ubiquitous agent of proteiform zoonotic disease].
Bartonella henselae is the causative agent of cat scratch disease, a human infection usually characterized by persistent regional lymphadenopathy. It is transmitted to humans by cat scratches or bites. Cats are the major reservoir for this bacterium thus B. henselae has a worldwide distribution. The bacterial pathogenicity may bay emphasized by the immune status of the infected host. Angiomatosis or hepatic peliosis are the most frequent clinical manifestations in immunocompromised patients. B. henselae is also responsible for endocarditis in patients with valvular diseases, and may induce various clinical presentations such as: bacteriemia, retinitis, musculoskeletal disorders, hepatic or splenic diseases, encephalitis, or myocarditis. Several diagnostic tools are available; they may be combined and adapted to every clinical setting. B. henselae is a fastidious bacterium; its diagnosis is mainly made by PCR and blood tests. No treatment is required for the benign form of cat scratch disease. For more severe clinical presentations, the treatment must be adapted to every clinical presentation.
Edouard
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CNRS, UMR6236, IRD 198, unité de recherche sur les maladies infectieuses tropicales et emergentes, Centre national de référence des Rickettsies, Bartonella et Coxiella, faculté de médecine, université de la Méditerranée, boulevard Jean-Moulin, Marseille cedex 5, France. sophie.edouard@ap-hm.fr
Raoult
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D000465:Algorithms; D016917:Angiomatosis, Bacillary / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology* / Q000635:transmission; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001431:Bacteriological Techniques; D018416:Bartonella henselae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity* / Q000502:physiology; D002371:Cat Diseases / Q000382:microbiology / Q000635:transmission; D002372:Cat-Scratch Disease / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology* / Q000635:transmission; D002415:Cats / Q000382:microbiology; D004197:Disease Reservoirs / Q000382:microbiology; D004697:Endocarditis, Bacterial / Q000209:etiology / Q000382:microbiology; D006801:Humans; D016867:Immunocompromised Host; D009140:Musculoskeletal Diseases / Q000209:etiology / Q000382:microbiology; D015835:Ocular Motility Disorders / Q000209:etiology / Q000382:microbiology; D010382:Peliosis Hepatis / Q000209:etiology / Q000382:microbiology; D012173:Retinitis / Q000209:etiology / Q000382:microbiology; D015047:Zoonoses
D000900:Anti-Bacterial Agents