title: A striking response of anorectal melanoma to radiotherapy (locoregional disease confined to perineum and anal canal).
abstract: Anorectal melanoma is a rare disease with an exceedingly poor prognosis. Literature evaluating outcomes is often difficult because of the infrequent diagnosis, delayed presentation and almost universally poor outcome. We describe a case of a 78-year-old woman with a large anorectal melanoma without detectable metastasis following radiological investigation. Due to the patient's co-morbidity, radiotherapy of 36 Gy once weekly over 7 weeks, was given as the sole treatment. The clinical outcome showed a remarkable regression of the tumour without radiological or clinical recurrence at 12 months' follow-up. This is the first case of the successful use of radiotherapy alone in anorectal melanoma.
authors.affiliation: St Georges Hospital, Tooting, London, UK. ashley.hay@doctors.org.uk
authors.forename: Ashley
authors.initials: A
authors.lastname: Hay
authors.forename: Janet
authors.initials: J
authors.lastname: Liong
authors.forename: Devinder
authors.initials: D
authors.lastname: Kumar
authors.forename: John
authors.initials: J
authors.lastname: Glees
mesh_terms: D000368:Aged; D001005:Anus Neoplasms / Q000532:radiotherapy; D005260:Female; D006801:Humans; D008545:Melanoma / Q000532:radiotherapy*; D010502:Perineum; D012004:Rectal Neoplasms / Q000532:radiotherapy*; D012074:Remission Induction; D016896:Treatment Outcome