title: Acute generalized exanthematous pustulosis induced by itraconazole: an immunological approach.
abstract: Acute generalized exanthematous pustulosis (AGEP) is an uncommon disease, which presents as a nonfollicular erythematous sterile pustular eruption. More than 90% of the cases are induced by adverse drug reactions, often triggered by anti-infectious systemic drugs. We report a case of itraconazole-induced AGEP in a 22-year-old man, with an assessment of his cytokine/chemokine production and drug-specific cell reactivity. We found that AGEP, like other T cell-mediated drug eruptions, alters the immunological status of the patient, probably favouring T-cell activation, recruitment and regulation. Few cases of itraconazole-induced AGEP have been described in the literature, and to our knowledge, this is the first report in which the cellular immunological features are assessed.
authors.affiliation: René Rachou Institute, Laboratory of Cellular and Molecular Immunology, Belo Horizonte, MG, Brazil.
authors.forename: G G L
authors.initials: GG
authors.lastname: Cançado
authors.forename: R T
authors.initials: RT
authors.lastname: Fujiwara
authors.forename: P A
authors.initials: PA
authors.lastname: Freitas
authors.forename: R
authors.initials: R
authors.lastname: Correa-Oliveira
authors.forename: J M
authors.initials: JM
authors.lastname: Bethony
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000139:chemically induced / Q000276:immunology*; D000935:Antifungal Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000276:immunology*; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects*; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D013601:T-Lymphocytes / Q000502:physiology; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole