title: [A new trincallane derivative from Salacia hainanensis Chun et How].
abstract: Chemical constituents of the roots and stem of Salacia hainanensis Chun et How were isolated and purified with column chromatography on silica gel, Sephadex LH-20 and preparative HPLC. Their structures were elucidated based on physicochemical and spectral spectroscopic analysis. Depending on the activities of anti-alpha-glucosidase and inhibiting AGEs (advanced glycation end products, AGEs) formation in vitro, nine compounds were identified as 26, 27-dihydroxy-7, 24-tirucalladien-3-one (1), abruslactone A (2), lupeol (3), 21alpha, 30-dihydroxy-D: A-friedooleanan-3-one (4), 15alpha-hydroxyfriedelan-3-one (5), friedelin (6), mangiferin (7), epicatechin (8) and beta-sitosterol (9), separately. Among them, compound 1 is a new compound, and compound 2 was isolated from the Salacia genus for the first time, while, compounds 3, 4, 5, 8 were obtained from this plant for the first time.
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Zheng-Hong
authors.initials: ZH
authors.lastname: Guo
authors.forename: Rong-Gang
authors.initials: RG
authors.lastname: Xi
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Wang
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Wu
authors.forename: Hui-Yuan
authors.initials: HY
authors.lastname: Gao
mesh_terms: D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes / Q000737:chemistry / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D049918:Salacia / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification; D000094042:Lupanes
chemical_list: D002392:Catechin; D053978:Pentacyclic Triterpenes; D013256:Steroids; D014315:Triterpenes; D044004:Xanthones; C573657:26,27-dihydroxy-7,24-tirucalladien-3-one; C573658:abruslactone A; C013592:mangiferin; C060796:friedelin; D000094042:Lupanes; C010480:lupeol