title: Plasma visfatin levels in pregnant women with normal glucose tolerance, gestational diabetes and pre-gestational diabetes mellitus.
abstract: OBJECTIVE
  Visfatin, an adipocytokine, is a peptide predominantly expressed in and secreted from visceral adipose. In this study, we aimed to compare visfatin levels in gestational (GDM) and pre-gestational diabetic (pre-GDM) women with healthy pregnant women. We also sought to determine whether there was a correlation between visfatin levels and serum glucose levels at 1 h after the 50-g oral glucose challenge test in pregnant women with GDM and normal glucose tolerance.
  
  
  METHODS
  The study consisted of 65 pregnant women: 21 patients with GDM (Group 1), 20 patients with pre-GDM (Group 2) and 24 gestational age and BMI-matched healthy pregnant women (Group 3) were enrolled.
  
  
  RESULTS
  Plasma visfatin levels in Groups 1 and 2 were significantly higher than in Group 3 (P < 0.001). Plasma visfatin levels in Groups 1 and 2 were similar (P > 0.05). There was no significant correlation between visfatin levels and serum glucose levels at 1 h after the glucose tolerance test in both Groups 1 and 3 (P > 0.05).
  
  
  CONCLUSIONS
  Our results support the literature indicating higher visfatin levels in women with GDM compared to women with normal glucose tolerance. Interestingly, we found similarly high visfatin levels in women with pre-GDM.
authors.affiliation: Department of Obstetrics and Gynecology, Kahramanmaras Sutcuimam University, Kahramanmaras, Turkey. acoskun@ksu.edu.tr
authors.forename: Ayhan
authors.initials: A
authors.lastname: Coskun
authors.forename: Mesut
authors.initials: M
authors.lastname: Ozkaya
authors.forename: Gurkan
authors.initials: G
authors.lastname: Kiran
authors.forename: Metin
authors.initials: M
authors.lastname: Kilinc
authors.forename: Deniz Cemgil
authors.initials: DC
authors.lastname: Arikan
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005865:Gestational Age; D018149:Glucose Intolerance / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D011236:Prediabetic State / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D054409:Nicotinamide Phosphoribosyltransferase