[Progress in the development of crystallized proteins as drug delivery system].
Crystallization has been widely applied in pharmaceutical formulations as an effective approach to improve the stability and efficacy of small agents. However protein crystals are suffered from limitation in the drug delivery system due to their complex crystallization behaviors. With development of crystallization technologies and their industrial application, protein crystals are receiving more and more attentions as a novel delivery system for biomacromolecules. Crystals with thermodynamic stable structure can improve the physical and chemical stability of protein drugs and present a sustained release behavior. On the basis of pertinent literatures, this review introduces the recent research situation and development process of protein crystals as drug delivery system. Moreover, the crystallization process of proteins, as well as the preparation and potential application are discussed systematically.
Shi
Kai
K
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Jiang
Yan-Bo
YB
Yang
Lin-Lin
LL
Cui
Fu-de
FD
D003460:Crystallization; D016503:Drug Delivery Systems; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011506:Proteins / Q000737:chemistry*
D004364:Pharmaceutical Preparations; D011506:Proteins