title: Secondary fibrosarcoma of the brain stem treated with cyclophosphamide and Imatinib.
abstract: Radiation-induced midbrain fibrosarcoma is a rare, highly aggressive tumor, which is associated with poor prognosis. We present the case of a 48-year old man with brainstem fibrosarcoma 20 years following radiation therapy received for a pituitary tumor. We discuss this case in the context of the diagnostic criteria for these tumors, and previous reports of secondary and primary sarcomas of the central nervous system.
authors.affiliation: Department of Neurological Surgery, University of California, Irvine, Irvine, CA, USA.
authors.forename: Daniela
authors.initials: D
authors.lastname: Alexandru
authors.forename: Denise K
authors.initials: DK
authors.lastname: Van Horn
authors.forename: Daniela Annenelie
authors.initials: DA
authors.lastname: Bota
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D020295:Brain Stem Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005354:Fibrosarcoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D000068877:Imatinib Mesylate; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008636:Mesencephalon / Q000473:pathology; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D009418:S100 Proteins / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D005904:Glial Fibrillary Acidic Protein; D010879:Piperazines; D011743:Pyrimidines; D009418:S100 Proteins; D000068877:Imatinib Mesylate; D003520:Cyclophosphamide