Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC.
The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by (32)P-post-labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.35-0.90), higher GSH levels (+1.87 micromol GSH g(-1) haemoglobin, p = 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.38-2.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.84-1.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.
Rundle
Andrew
A
Columbia University Mailman School of Public Health, New York, NY, USA.
Richie
John
J
Steindorf
Karen
K
Peluso
Marco
M
Overvad
Kim
K
Raaschou-Nielsen
Ole
O
Clavel-Chapelon
Francoise
F
Linseisen
Jacob P
JP
Boeing
Heiner
H
Trichopoulou
Antonia
A
Palli
Domenico
D
Krogh
Vittorio
V
Tumino
Rosario
R
Panico
Salvatore
S
Bueno-De-Mesquita
Hendrik B
HB
Peeters
Petra H
PH
Lund
Eiliv
E
Gonzalez
Carlos A
CA
Martinez
Carmen
C
Dorronsoro
Miren
M
Barricarte
Aurelio
A
Tormo
M Jose
MJ
Quiros
Josèr
J
Agudo
Antonio
A
Berglund
Goran
G
Jarvholm
Bengt
B
Bingham
Sheila
S
Key
Timothy J
TJ
Gormally
Emmanuelle
E
Saracci
Rodolfo
R
Kaaks
Rudolf
R
Riboli
Elio
E
Vineis
Paolo
P
D000368:Aged; D015415:Biomarkers; D016022:Case-Control Studies; D018736:DNA Adducts / Q000032:analysis; D004912:Erythrocytes / Q000737:chemistry; D005060:Europe / Q000453:epidemiology; D005260:Female; D005978:Glutathione / Q000032:analysis; D006801:Humans; D007962:Leukocytes / Q000737:chemistry; D008175:Lung Neoplasms / Q000097:blood / Q000453:epidemiology* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology / Q000379:methods; D009043:Motor Activity; D010865:Pilot Projects; D012307:Risk Factors; D012907:Smoking
D015415:Biomarkers; D018736:DNA Adducts; D005978:Glutathione