title: Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients.
abstract: Little is known about clinical and virologic manifestations of rhinovirus (HRV) and coronavirus (HCoV) infections after hematopoietic cell transplantation (HCT). We performed surveillance for 1 year and describe the natural history of these infections during the first 100 days after allogeneic HCT, when symptom surveys and upper respiratory samples were collected weekly. Samples were tested using RT-PCR for HRVs and HCoVs (OC43, 229E, HKU1, and NL63). Among 215 patients, 64 (30%) patients had 67 infections. Day 100 cumulative incidence estimate was 22.3% for HRV and 11.1% for HCoV. Median duration of viral shedding was 3 weeks; prolonged shedding of at least 3 months occurred in 6 of 45 patients with HRV and 3 of 22 with HCoV. Six patients with HRV and 9 with HCoV were asymptomatic. HRV infection was associated with rhinorrhea, congestion, postnasal drip, sputum, and cough; HCoV infection was not associated with respiratory symptoms or hepatic dysfunction. Lower respiratory infection developed in 2 patients with HRV before day 100, and 1 each with HRV and HCoV after day 100. HRV and HCoV infections are common in the first 100 days after HCT, viral shedding lasts more than 3 weeks in half, and lower respiratory infection is rare.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: Filippo
authors.initials: F
authors.lastname: Milano
authors.forename: Angela P
authors.initials: AP
authors.lastname: Campbell
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Guthrie
authors.forename: Jane
authors.initials: J
authors.lastname: Kuypers
authors.forename: Janet A
authors.initials: JA
authors.lastname: Englund
authors.forename: Lawrence
authors.initials: L
authors.lastname: Corey
authors.forename: Michael
authors.initials: M
authors.lastname: Boeckh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D002522:Chlorocebus aethiops; D003333:Coronaviridae Infections / Q000175:diagnosis / Q000453:epidemiology*; D017934:Coronavirus / Q000302:isolation & purification*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D007223:Infant; D008253:Macaca mulatta; D008297:Male; D008875:Middle Aged; D010850:Picornaviridae Infections / Q000175:diagnosis / Q000453:epidemiology*; D012229:Rhinovirus / Q000302:isolation & purification*; D014184:Transplantation, Homologous; D055815:Young Adult