title: Transient involvement of the cerebral cortex in a flare of Behçet's syndrome.
abstract: We describe a flare of Behçet's syndrome in a 42-year-old man who presented with florid mucocutaneous manifestations, headache and vomiting, but without meningeal or neurologic signs. A single, non-enhancing cortical lesion was found in the frontal lobe by computed tomography and magnetic resonance (MR) imaging studies. Diffusion-weighted analysis and MR spectroscopy were consistent with focal inflammation. The patient improved with colchicine, and after 5 months, a repeat MR scan demonstrated resolution of the inflammatory changes suggesting that involvement of the cerebral cortex may be a self-limiting phenomenon, distinct from other more frequent and destructive parenchymal manifestations of neuro-Behçet's disease.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates. walter.conca@uaeu.ac.ae
authors.forename: Walter
authors.initials: W
authors.lastname: Conca
authors.forename: Soliman A
authors.initials: SA
authors.lastname: Kamel
authors.forename: Dominic
authors.initials: D
authors.lastname: Venne
authors.forename: Peter
authors.initials: P
authors.lastname: Corr
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D001921:Brain / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D003078:Colchicine / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008590:Meningoencephalitis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D050257:Tubulin Modulators / Q000627:therapeutic use*
chemical_list: D050257:Tubulin Modulators; D003078:Colchicine