title: Synthesis of nano-sized biphasic calcium phosphate ceramics with spherical shape by flame spray pyrolysis.
abstract: Nanometer size biphasic calcium phosphate (BCP) powders with various Ca/P molar ratios satisfied with appropriate phase ratios of HA/beta-TCP were prepared by high temperature flame spray pyrolysis process. The BCP powders had spherical shapes and narrow size distributions irrespective of the ratios of Ca/P. The mean size of the BCP powders measured from the TEM image was 38 nm. The composition ratio of Ca/P was controlled from 1.500 to 1.723 in the spray solution, and required phase ratios of HA/TCP are controlled systematically. The calcium dissolution of the pellets obtained from the BCP powders directly prepared by flame spray pyrolysis in buffer solution increased with the decrease of Ca/P ratios except with the Ca/P ratio of 1.713. The pellet surface with Ca/P ratio of 1.500, which consisted of beta-TCP, was eroded dramatically for 7 days. On the other hand, the pellet surface with Ca/P ratio of 1.667 was stable and did not disintegrate after immersion in Tris-HCl buffer solution based on the SEM observation.
authors.affiliation: Department of Chemical Engineering, Konkuk University, Seoul, Korea.
authors.forename: Jung Sang
authors.initials: JS
authors.lastname: Cho
authors.forename: You Na
authors.initials: YN
authors.lastname: Ko
authors.forename: Hye Young
authors.initials: HY
authors.lastname: Koo
authors.forename: Yun Chan
authors.initials: YC
authors.lastname: Kang
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry*; D002516:Ceramics / Q000138:chemical synthesis* / Q000737:chemistry; D005410:Flame Ionization / Q000295:instrumentation / Q000379:methods; D006358:Hot Temperature; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry; D009994:Osmolar Concentration; D010316:Particle Size; D011208:Powders; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D011208:Powders; C020243:calcium phosphate