[Neoadjuvant chemotherapy and pancreatoduodenectomy for locally advanced colon cancer].
A 62-year-old man was referred to our hospital with the chief complaint of a palpable abdominal mass. Type 1 tumor was found in the ascending colon on fiberscopic examination, and pathologic examination revealed moderate to highly differentiated adenocarcinoma. Computed tomography of the abdomen demonstrated a main tumor and an adjacent large mass which was suspected to be lymph node metastasis. The tumor invaded the superior mesenteric vein( SMV) and pancreas. On the first laparotomy, a curative resection was difficult, and chemotherapy was planned. The FOLFIRI regimen was effective, but adverse events such as fever and general fatigue gradually became pronounced. Even after the change to FOLFOX, these adverse events did not improve, and we therefore decided to perform a radical resection. The patient is still alive and disease-free 8 months after surgery.
Miki
Yuichiro
Y
Department of Surgery, National Hospital Organization, Osaka National Hospital.
Ikenaga
Masakazu
M
Miyamoto
Atsushi
A
Tsujie
Masanori
M
Yasui
Masayoshi
M
Miyazaki
Michihiko
M
Hirao
Motohiro
M
Fujitani
Kazumasa
K
Mishima
Hideyuki
H
Nakamori
Shoji
S
Tsujinaka
Toshimasa
T
D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002166:Camptothecin / Q000031:analogs & derivatives / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000473:pathology / Q000628:therapy*; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D016577:Pancreaticoduodenectomy
D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin