title: Synthesis, cytotoxicity, antiviral activity and interferon inducing ability of 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines.
abstract: New 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines were synthesized with high yields using bromoethylisatin and 6-(2-bromoethyl)-6H-indolo[2,3-b]quinoxaline as intermediates. These compounds were screened for the cytotoxicity, antiviral activity and interferon inducing ability. It was shown, that tested 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxalines are low toxic potent interferon inducers and antivirals. Morpholine and 4-methyl-piperidine derivatives appeared as the most active antivirals and the least cytotoxic in the investigated series.
authors.affiliation: AV Bogatsky Physico-Chemical Institute of NAS of Ukraine, Lyustdorfskaya doroga 86, Odessa 65080, Ukraine.
authors.forename: Marina O
authors.initials: MO
authors.lastname: Shibinskaya
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Lyakhov
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Mazepa
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Andronati
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Turov
authors.forename: Nadezhda M
authors.initials: NM
authors.lastname: Zholobak
authors.forename: Nikolay Ya
authors.initials: NY
authors.lastname: Spivak
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D005347:Fibroblasts / Q000187:drug effects; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007372:Interferons / Q000378:metabolism*; D051379:Mice; D015394:Molecular Structure; D011810:Quinoxalines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013552:Swine; D018116:Vesiculovirus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D007211:Indoles; D011810:Quinoxalines; D007372:Interferons