A divergent strategy for attaching polypyridyl ligands to peptides.
A divergent method for incorporating polypyridyl ligands into peptides is reported. Three N-Fmoc unnatural amino acids (1-3) that contain varying linkers between the alpha-carbon and a 2-(hydroxymethyl)pyridyl group were synthesized in enantioenriched form. These amino acids were used as anchors for incorporating multidentate ligands onto a peptide chain in a site-specific fashion. Multiple peptide-ligand conjugates were synthesized from single precursors by solution- or solid-phase methods. Peptides containing more than one metal-binding unit can be produced by this method.
Jabre
Nitinkumar D
ND
Department of Chemistry, Wayne State Universty, 5101 Cass Ave, Detroit, Michigan 48202, USA.
Respondek
Tomasz
T
Ulku
Selma A
SA
Korostelova
Nadiya
N
Kodanko
Jeremy J
JJ
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D017510:Protein Folding; D011725:Pyridines / Q000737:chemistry*; D012996:Solutions
D000596:Amino Acids; D008024:Ligands; D008670:Metals; D009942:Organometallic Compounds; D010455:Peptides; D011725:Pyridines; D012996:Solutions