Synthesis, in vitro and in vivo studies of Gd-DTPA-XDA-D1-Glc(OH) complex as a new potential MRI contrast agent.
A new type of dendritic molecules Gd-DTPA-XDA-D1-Glc(OH), which work as a functionalized ligand coordinating gadolinium(III) ion at the center of their frameworks with two glucose moieties on the molecular surfaces, were readily synthesized with high yield. The structures were established by IR, (1)H, (13)C NMR, and mass spectral studies. Its bio-distribution patterns were evaluated on rats.
Ozaki
Nobuhisa
N
Graduate School of Science and Technology, Shizuoka University, Hamamatsu 432-8561, Japan.
Sankar
Arigala Uma Ravi
AU
Yamashita
Mitsuji
M
Aoki
Takashi
T
Tanaka
Yasutaka
Y
Kimura
Motohiko
M
Toda
Mitsuo
M
Fujie
Michio
M
Takehara
Yasuo
Y
Sakahara
Harumi
H
D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis*; D019786:Gadolinium DTPA / Q000032:analysis / Q000138:chemical synthesis*; D005947:Glucose / Q000032:analysis / Q000138:chemical synthesis*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods; D011877:Radionuclide Imaging; D051381:Rats
D003287:Contrast Media; D005947:Glucose; D019786:Gadolinium DTPA