title: Octacalcium phosphate (OCP) collagen composites enhance bone healing in a dog tooth extraction socket model.
abstract: The authors have reported that a scaffold constructed of synthetic octacalcium phosphate (OCP) and porcine atelocollagen sponge (OCP/Col) enhanced bone regeneration more than sintered beta-tricalcium phosphate collagen composite or sintered hydroxyapatite collagen composite with a rat calvarial defect model. To aim for clinical application, the present study investigated whether OCP/Col would enhance bone healing in a dog tooth extraction socket model. Six adult, male, beagle dogs were used. The tooth extraction socket model was made by extracting bilateral third maxillary incisors and the subsequent removal of buccal bone. Disks of OCP/Col were implanted into one side of the model and the other side was untreated. The specimens were fixed 1 or 3 months after implantation. In radiographic analysis, the OCP/Col-treated group showed a wider range of radiopacity than the untreated control. Histologically, the OCP/Col-treated group showed more abundant newly formed bone than untreated control, and the implanted OCP was gradually resorbed. In morphometrical analysis, enlargement of the buccal alveolus in the OCP/Col group was significantly greater than in the untreated control. This study showed that implanted OCP/Col would be replaced by newly formed bone and OCP/Col implantation would enhance bone healing in a tooth socket model.
authors.affiliation: Division of Oral Surgery, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, Sendai, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Iibuchi
authors.forename: K
authors.initials: K
authors.lastname: Matsui
authors.forename: T
authors.initials: T
authors.lastname: Kawai
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
authors.forename: O
authors.initials: O
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Kamakura
authors.forename: S
authors.initials: S
authors.lastname: Echigo
mesh_terms: D020341:Absorbable Implants; D000539:Alveolar Process / Q000000981:diagnostic imaging / Q000473:pathology; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000032:analysis / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000032:analysis / Q000627:therapeutic use*; D003094:Collagen / Q000032:analysis / Q000627:therapeutic use*; D004285:Dogs; D017886:Durapatite / Q000032:analysis; D007091:Image Processing, Computer-Assisted; D007180:Incisor / Q000601:surgery; D008297:Male; D008437:Maxilla / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008852:Microradiography; D010012:Osteogenesis / Q000502:physiology; D017550:Spectroscopy, Fourier Transform Infrared; D014081:Tooth Extraction; D020390:Tooth Socket / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D014945:Wound Healing / Q000502:physiology
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C059821:atelocollagen; C022045:octacalcium phosphate; D003094:Collagen; D017886:Durapatite