title: [A new method of short-term high volume (6 g of 5-FU in a week) intermittent hepatic arterial infusion using repeated transient catheter insertion].
abstract: We report a case of liver metastases, which had hepatectomy twice and a partial lung resection after sigmoidectomy with partial bladder resection for advanced sigmoid colon cancer. The patient could not be tolerated the systemic chemotherapy, and percutaneous implantation of a catheter also could not have done with subcutaneous reservoir for hepatic arterial infusion because of an anomaly of hepatic artery branched-out from super mesenteric artery. Therefore, we tried an intermittent hepatic arterial infusion using a transient insertion of catheter to control the liver metastases' growth. A total amount of 6 g of 5-FU was continuously injected in a week by one insertion of catheter at the hepatic artery taking one day rest at day 4. During the next 21 months, a total of 11 courses have been done. CEA and CA19-9 were changed from 15 ng/mL, 48 U/ mL to 18, 30, respectively. The patient was able to keep working except for the duration of this treatment. This procedure could be one of the hepatic arterial infusion options.
authors.affiliation: Department of Surgery, Iseikai Hospital.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Hasuike
authors.forename: Takahiko
authors.initials: T
authors.lastname: Tanigawa
authors.forename: Masaharu
authors.initials: M
authors.lastname: Yamada
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Minami
authors.forename: Koji
authors.initials: K
authors.lastname: Ezumi
authors.forename: Atsuya
authors.initials: A
authors.lastname: Okada
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D002404:Catheterization / Q000379:methods; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery / Q000002:abnormalities; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D012811:Sigmoid Neoplasms / Q000473:pathology / Q000601:surgery
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil