title: Shape-dependent sensitivity of single plasmonic nanoparticles for biosensing.
abstract: Shape-dependent sensitivity of localized surface plasmon-based biosensing was investigated by combining single-particle protein-sensing and multiple multipole program simulation. Significantly higher sensitivity was observed for tetrahedral particles than spherical ones, which was revealed by careful structural analysis of individually measured particles. The simulation of the corresponding particles with layered protein adsorption model showed consistent optical property and sensitivity, which were explained in terms of the field enhancement at the pointing edges.
authors.affiliation: Swiss Federal Institute of Technology Zurich, Institute for Biomedical Engineering, Laboratory of Biosensors and Bioelectronics, Gloriastrasse 35, Zurich, 8092 Switzerland. sannomiya@biomed.ee.ethz.ch
authors.forename: Takumi
authors.initials: T
authors.lastname: Sannomiya
authors.forename: Christian
authors.initials: C
authors.lastname: Hafner
authors.forename: Janos
authors.initials: J
authors.lastname: Vörös
mesh_terms: D000327:Adsorption; D015374:Biosensing Techniques / Q000379:methods*; D003102:Colloids / Q000737:chemistry; D003198:Computer Simulation; D004574:Electromagnetic Fields; D006046:Gold / Q000737:chemistry; D007074:Immunoglobulin G / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D020349:Surface Plasmon Resonance / Q000379:methods*
chemical_list: D003102:Colloids; D007074:Immunoglobulin G; D006046:Gold