title: Hydrogen: another gas with therapeutic potential.
abstract: Cardinal and colleagues describe the use of molecular hydrogen, the most abundant molecule in the universe, as a treatment for chronic allograft nephropathy (CAN) in a rat model of kidney transplantation. They demonstrate that the addition of hydrogen to the drinking water results in a decrease in the severity of CAN and increased graft survival, and they provide evidence that the mechanism of action could be due to a reduction in reactive oxygen species.
authors.affiliation: [1] Department of Surgery, Division of Cardiothoracic Surgery, University of Alabama at Birmingham, 1900 University Boulevard, Birmingham, AL 35294, USA.
authors.forename: James F
authors.initials: JF
authors.lastname: George
authors.forename: Anupam
authors.initials: A
authors.lastname: Agarwal
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D006859:Hydrogen / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000009:adverse effects*; D051436:Renal Insufficiency, Chronic / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000975:Antioxidants; D006859:Hydrogen