title: Association of toll-like receptor 2 gene polymorphisms with normal tension glaucoma.
abstract: OBJECTIVE
  Toll-like receptor 2 (TLR2) is a transmembrane receptor that mediates immune responses to exogenous and endogenous ligands, and interacts with heat-shock proteins, which are reportedly involved in normal tension glaucoma (NTG). We investigated whether TLR2 polymorphisms are associated with NTG.
  
  
  METHODS
  200 Japanese patients with NTG and 128 healthy Japanese controls were recruited. We genotyped five single-nucleotide polymorphisms (SNPs) in the TLR2 gene and assessed the allele and haplotype diversities between cases and controls for all SNPs.
  
  
  RESULTS
  No significant differences in the frequency of TLR2 alleles and haplotypes in the NTG cases were detected, compared with the controls.
  
  
  CONCLUSIONS
  Our study showed no evidence for an association between TLR2 polymorphisms and NTG. TLR2 polymorphisms may not play an important role in NTG pathogenesis in the Japanese population.
authors.affiliation: Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
authors.forename: Jutaro
authors.initials: J
authors.lastname: Nakamura
authors.forename: Akira
authors.initials: A
authors.lastname: Meguro
authors.forename: Masao
authors.initials: M
authors.lastname: Ota
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nomura
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Nishide
authors.forename: Kenji
authors.initials: K
authors.lastname: Kashiwagi
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Mabuchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iijima
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Kawase
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakamura
authors.forename: Akira
authors.initials: A
authors.lastname: Negi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sagara
authors.forename: Teruo
authors.initials: T
authors.lastname: Nishida
authors.forename: Masaru
authors.initials: M
authors.lastname: Inatani
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Tanihara
authors.forename: Makoto
authors.initials: M
authors.lastname: Aihara
authors.forename: Makoto
authors.initials: M
authors.lastname: Araie
authors.forename: Takeo
authors.initials: T
authors.lastname: Fukuchi
authors.forename: Haruki
authors.initials: H
authors.lastname: Abe
authors.forename: Tomomi
authors.initials: T
authors.lastname: Higashide
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Sugiyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanamoto
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kiuchi
authors.forename: Aiko
authors.initials: A
authors.lastname: Iwase
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ohno
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Mizuki
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D057066:Low Tension Glaucoma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D055815:Young Adult
chemical_list: C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2