title: Metabolic syndrome, mild cognitive impairment, and progression to dementia. The Italian Longitudinal Study on Aging.
abstract: We investigated the relationship of metabolic syndrome (MetS) and its individual components with incidence of mild cognitive impairment (MCI) and its progression to dementia in a large longitudinal Italian population-based sample with a 3.5-year follow-up. A total of 2097 participants from a sample of 5632 65-84-year-old subjects from the Italian Longitudinal Study on Aging were evaluated. MetS was defined according to the Third Adults Treatment Panel of the National Cholesterol Education Program criteria. MCI, dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were classified using current published criteria. Among MCI patients those with MetS (N=49) had a higher risk of progression to dementia (HR, 4.40; 95% CI, 1.30-14.82) compared with those without MetS (N=72). After a multivariate adjustment, the risk in MCI patients with MetS approximately doubled (multivariate adjusted HR, 7.80, 95% CI 1.29-47.20) compared with those MCI without MetS. Finally, among non-cognitively impaired individuals there were no significant differences in risks of developing MCI in those who were affected by MetS (N=608) in comparison with those without MetS (N=837), as well as excluding those individuals with undernutrition or low inflammatory status with or without undernutrition. In our population, among MCI patients the presence of MetS independently predicted an increased risk of progression to dementia over 3.5 years of follow-up.
authors.affiliation: Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Solfrizzi
authors.forename: Emanuele
authors.initials: E
authors.lastname: Scafato
authors.forename: Cristiano
authors.initials: C
authors.lastname: Capurso
authors.forename: Alessia
authors.initials: A
authors.lastname: D'Introno
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Colacicco
authors.forename: Vincenza
authors.initials: V
authors.lastname: Frisardi
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Vendemiale
authors.forename: Marzia
authors.initials: M
authors.lastname: Baldereschi
authors.forename: Gaetano
authors.initials: G
authors.lastname: Crepaldi
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Carlo
authors.forename: Lucia
authors.initials: L
authors.lastname: Galluzzo
authors.forename: Claudia
authors.initials: C
authors.lastname: Gandin
authors.forename: Domenico
authors.initials: D
authors.lastname: Inzitari
authors.forename: Stefania
authors.initials: S
authors.lastname: Maggi
authors.forename: Antonio
authors.initials: A
authors.lastname: Capurso
authors.forename: Francesco
authors.initials: F
authors.lastname: Panza
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D060825:Cognitive Dysfunction / Q000150:complications / Q000453:epidemiology*; D003704:Dementia / Q000453:epidemiology* / Q000209:etiology; D018450:Disease Progression; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy; D008137:Longitudinal Studies; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors