title: Flavonol glycosides of sea buckthorn (Hippophaë rhamnoides ssp. sinensis) and lingonberry (Vaccinium vitis-idaea) are bioavailable in humans and monoglucuronidated for excretion.
abstract: Glucuronidation and excretion of sea buckthorn and lingonberry flavonols were investigated in a postprandial trial by analyzing the intact forms of flavonol glycosides as well as glucuronides in plasma, urine, and feces. Four study subjects consumed sea buckthorn (study day 1) and lingonberry (study day 2) breakfasts, and blood, urine, and fecal samples were collected for 8, 24, and 48 h, respectively. Both glycosides and glucuronides of the flavonol quercetin as well as kaempferol glucuronides were detected in urine and plasma samples after the consumption of lingonberries; 14% of flavonols in urine were glycosides, and 86% were glucuronidated forms (wt %). After the consumption of sea buckthorn, 5% of flavonols excreted in urine were detected intact, and 95% as the glucuronides (wt %). Solely glucuronides of flavonols isorhamnetin and quercetin were found in plasma after the consumption of sea buckthorn berries. Only glycosides were detected in the feces after each berry trial. Flavonol glycosides and glucuronides remained in blood and urine quite long, and the peak concentrations appeared slightly later than previously described. The berries seemed to serve as a good flavonol supply, providing steady flavonol input for the body for a relatively long time.
authors.affiliation: Department of Biochemistry and Food Chemistry, University of Turku, Finland. henna-maria.lehtonen@utu.fi
authors.forename: Henna-Maria
authors.initials: HM
authors.lastname: Lehtonen
authors.forename: Outi
authors.initials: O
authors.lastname: Lehtinen
authors.forename: Jukka-Pekka
authors.initials: JP
authors.lastname: Suomela
authors.forename: Matti
authors.initials: M
authors.lastname: Viitanen
authors.forename: Heikki
authors.initials: H
authors.lastname: Kallio
mesh_terms: D000328:Adult; D001682:Biological Availability; D005243:Feces / Q000737:chemistry*; D005260:Female; D044948:Flavonols / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D020719:Glucuronides / Q000378:metabolism*; D006027:Glycosides / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D031281:Hippophae / Q000737:chemistry*; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D029801:Vaccinium vitis-idaea / Q000737:chemistry*; D055815:Young Adult
chemical_list: D044948:Flavonols; D020719:Glucuronides; D006027:Glycosides; D010936:Plant Extracts