The functional genotype of glutathione S-transferase T1 gene is strongly associated with increased risk of idiopathic infertility in Russian men.
This study was designed to investigate the association between null polymorphisms of glutathione S-transferase (GST) M1 and T1 genes and idiopathic male infertility in a Russian population including 203 infertile and 227 fertile men. The nondeletion genotype of the GSTT1 gene was found to be strongly associated with the increased risk of idiopathic male infertility and asthenozoospermia.
Polonikov
Alexey V
AV
Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University, Kursk, Russia. polonikov@rambler.ru
Yarosh
Sergey L
SL
Kokhtenko
Elena V
EV
Starodubova
Nina I
NI
Pakhomov
Sergey P
SP
Orlova
Valentina S
VS
D000328:Adult; D016022:Case-Control Studies; D017353:Gene Deletion; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics* / Q000502:physiology; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D012306:Risk; D012426:Russia; D055815:Young Adult
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1