Frequency of vacuolating cytotoxin A (VacA)-positive Helicobacter pylori seropositivity and TGF-β1 decrease in atrial fibrillation.
The study was performed to determine whether there were any associations of VacA positive Helicobacter pylori and TGF-β1 with atrial fibrillation (AF). The serum levels of antibodies to H. pylori and VacA, and cytokines were assessed using ELISA in 96 subjects. While elevated levels of TNF-α, IL-6 and CRP were associated with AF, TGF-β(1) was significantly lowered in AF patients (p=0.021). In addition, AF was associated with elevated levels of antibodies to VacA (p=0.023), compared to the control group. Accordingly, the chronic infection of VacA(+)H. pylori may increase the risk for AF by inducing systemic inflammation mediated, partly by suppressed TGF-β(1) and elevated proinflammatory cytokines.
Ki
Mi-Ran
MR
College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
Shin
Dong-Gu
DG
Cardiovascular division, Internal Medicine, Yeungnam University Medical Center, Daegu, Republic of Korea.
Park
Jong-Sun
JS
Cardiovascular division, Internal Medicine, Yeungnam University Medical Center, Daegu, Republic of Korea.
Hong
Kyung-Sook
KS
College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
Hong
Il-Hwa
IH
College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
Park
Jin-Kyu
JK
College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jeong
Kyu-Shik
KS
College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address: jeongks@knu.ac.kr.
D001281:Atrial Fibrillation / Q000097:blood / Q000382:microbiology* / Q000473:pathology; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D003603:Cytotoxins / Q000096:biosynthesis / Q000097:blood*; D005260:Female; D016481:Helicobacter Infections / Q000097:blood / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000382:microbiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D053773:Transforming Growth Factor beta1 / Q000037:antagonists & inhibitors* / Q000097:blood*
D001426:Bacterial Proteins; D015415:Biomarkers; D003603:Cytotoxins; D053773:Transforming Growth Factor beta1; C074689:VacA protein, Helicobacter pylori