title: Copper-catalyzed annulation of 2-formylazoles with o-aminoiodoarenes.
abstract: In the presence of catalytic CuI and sparteine, 2-formylpyrroles can be annulated with o-aminoiodoarenes to give substituted pyrrolo[1,2-a]quinoxalines and related heterocycles. The reaction also works for annulation of 2-formylindoles, 2-formylimidazole, 2-formylbenzimidazole, and a 3-formylpyrazole.
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Old Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, USA. jonathan.reeves@boehringer-ingelheim.com
authors.forename: Jonathan T
authors.initials: JT
authors.lastname: Reeves
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Fandrick
authors.forename: Zhulin
authors.initials: Z
authors.lastname: Tan
authors.forename: Jinhua J
authors.initials: JJ
authors.lastname: Song
authors.forename: Heewon
authors.initials: H
authors.lastname: Lee
authors.forename: Nathan K
authors.initials: NK
authors.lastname: Yee
authors.forename: Chris H
authors.initials: CH
authors.lastname: Senanayake
mesh_terms: D001393:Azoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003432:Cross-Linking Reagents; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D001393:Azoles; D003432:Cross-Linking Reagents; D006571:Heterocyclic Compounds; D003300:Copper