title: Soy product and isoflavone intakes are associated with a lower risk of type 2 diabetes in overweight Japanese women.
abstract: Isoflavones have been shown to improve glucose metabolism, but epidemiologic data are limited. We prospectively investigated the relationship between soy product and isoflavone intake and the risk of developing type 2 diabetes among Japanese adults. Participants were 25,872 men and 33,919 women aged 45-75 y, who participated in the second survey of the Japan Public Health Center-Based Prospective Study and had no history of diabetes. Soy product and isoflavone intakes were ascertained using a 147-item FFQ. Odds ratios of self-reported, physician-diagnosed type 2 diabetes over 5 y were estimated using logistic regression analysis. A total of 1114 new cases of type 2 diabetes were self-reported. Intakes of soy products and isoflavones were not significantly associated with type 2 diabetes in either men or all women. However, among overweight women (BMI > or = 25 kg/m(2)), a higher intake of soy products was associated with a lower risk of type 2 diabetes; multivariable-adjusted odds ratios (95% CI) for the lowest through highest quintiles of soy product intake were 1.00 (reference), 0.78 (0.52-1.18), 0.79 (0.52-1.20), 0.62 (0.39-0.99), and 0.89 (0.55-1.44), respectively, and we found a similar risk pattern for daidzein and genistein intakes. Overall, our results suggest that there are no benefits of soy product or isoflavone intake with respect to risk of type 2 diabetes in either men or women. The possible protective associations of soy and isoflavone intakes among overweight women deserves further investigation.
authors.affiliation: Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Shinjuku-ku, Tokyo 162-8655, Japan. nanri@ri.imcj.go.jp
authors.forename: Akiko
authors.initials: A
authors.lastname: Nanri
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mizoue
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kirii
authors.forename: Manami
authors.initials: M
authors.lastname: Inoue
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Noda
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tsugane
mesh_terms: D000293:Adolescent; D044466:Asian People; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage* / Q000494:pharmacology; D050177:Overweight / Q000150:complications*; D045730:Soy Foods; D055815:Young Adult
chemical_list: D007529:Isoflavones