title: [Anthelmintic activity of aqueous extract of Zanthoxylum rhoifolium Lam. leaves (Rutaceae)].
abstract: The study evaluated the anthelmintic activity of aqueous extract of Zanthoxylum rhoifolium leaves in two experiments. In vitro test, cultures of goat fecal samples were treated with different concentrations of extract (134.5 to 335.0 mg.mL(-1)). In vivo test was composed of 20 sheep: G1: treated with 0.63 g.kg(-1), during four days; G2: same dose, for eight days; G3: ivermectin (200 microg.kg(-1)) and G4 untreated group. In vitro results showed a reduction of Haemonchus spp, Trichostrongylus spp. and Oesophagostomum spp. larvae greater than 95% in the concentrations between 335.0 and 193.7 mg.mL(-1). Faecal egg counting reduction was 51, 56 and 90% in G1, G2 and G3, respectively, while immature stages and adults ranged from 0 to 91% in G1 and from 26 to 94% in G2. Ivermectin effectiveness was 99% for L4 and L5 of H. contortus and 100% for other nematodes species. Clinical and biochemical parameters have remained in the normality and histophatologic analyses did not show alteration suggesting absence of toxicity. Although the great effectiveness of Z. rhoifolium leaves extract in vitro test, it displayed poor efficiency in vivo regarding gastrointestinal nematodes reduction.
authors.affiliation: União Metropolitana de Educação e Cultura-UNIME, Av. Luis Tarquínio Pontes, 600, CEP 42700-000, Lauro de Freitas-BA, Brazil. taisepeneluc@hotmail.com
authors.forename: Taíse
authors.initials: T
authors.lastname: Peneluc
authors.forename: Luciana Ferreira
authors.initials: LF
authors.lastname: Domingues
authors.forename: Gisele Nunes
authors.initials: GN
authors.lastname: de Almeida
authors.forename: Maria Consuelo Caribé
authors.initials: MC
authors.lastname: Ayres
authors.forename: Eduardo Luiz Trindade
authors.initials: EL
authors.lastname: Moreira
authors.forename: Ana Carla Ferreira
authors.initials: AC
authors.lastname: da Cruz
authors.forename: Thereza Cristina Bório
authors.initials: TC
authors.lastname: dos Santos Calmon de Bittencourt
authors.forename: Maria Angela Ornelas
authors.initials: MA
authors.lastname: de Almeida
authors.forename: Maria José Moreira
authors.initials: MJ
authors.lastname: Batatinha
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D006376:Helminths / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D014867:Water; D032106:Zanthoxylum
chemical_list: D000871:Anthelmintics; D010936:Plant Extracts; D014867:Water