title: Psychological treatments of binge eating disorder.
abstract: BACKGROUND
  Interpersonal psychotherapy (IPT) is an effective specialty treatment for binge eating disorder (BED). Behavioral weight loss treatment (BWL) and guided self-help based on cognitive behavior therapy (CBTgsh) have both resulted in short-term reductions in binge eating in obese patients with BED.
  
  
  OBJECTIVE
  To test whether patients with BED require specialty therapy beyond BWL and whether IPT is more effective than either BWL or CBTgsh in patients with a high negative affect during a 2-year follow-up.
  
  
  METHODS
  Randomized, active control efficacy trial.
  
  
  METHODS
  University outpatient clinics.
  
  
  METHODS
  Two hundred five women and men with a body mass index between 27 and 45 who met DSM-IV criteria for BED. Intervention Twenty sessions of IPT or BWL or 10 sessions of CBTgsh during 6 months.
  
  
  METHODS
  Binge eating assessed by the Eating Disorder Examination.
  
  
  RESULTS
  At 2-year follow-up, both IPT and CBTgsh resulted in greater remission from binge eating than BWL (P < .05; odds ratios: BWL vs CBTgsh, 2.3; BWL vs IPT, 2.6; and CBTgsh vs IPT, 1.2). Self-esteem (P < .05) and global Eating Disorder Examination (P < .05) scores were moderators of treatment outcome. The odds ratios for low and high global Eating Disorder Examination scores were 2.8 for BWL, 2.9 for CBTgsh, and 0.73 for IPT; for self-esteem, they were 2.4 for BWL, 1.9 for CBTgsh, and 0.9 for IPT.
  
  
  CONCLUSIONS
  Interpersonal psychotherapy and CBTgsh are significantly more effective than BWL in eliminating binge eating after 2 years. Guided self-help based on cognitive behavior therapy is a first-line treatment option for most patients with BED, with IPT (or full cognitive behavior therapy) used for patients with low self-esteem and high eating disorder psychopathology.
  
  
  BACKGROUND
  clinicaltrials.gov Identifier: NCT00060762.
authors.affiliation: The State University of New Jersey, Piscataway, NJ 08854, USA. tewilson@rci.rutgers.edu
authors.forename: G Terence
authors.initials: GT
authors.lastname: Wilson
authors.forename: Denise E
authors.initials: DE
authors.lastname: Wilfley
authors.forename: W Stewart
authors.initials: WS
authors.lastname: Agras
authors.forename: Susan W
authors.initials: SW
authors.lastname: Bryson
mesh_terms: D000328:Adult; D001521:Behavior Therapy / Q000379:methods; D056912:Binge-Eating Disorder / Q000628:therapy*; D015992:Body Mass Index; D015928:Cognitive Behavioral Therapy / Q000379:methods; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007398:Interpersonal Relations; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000523:psychology / Q000628:therapy; D011569:Psychiatric Status Rating Scales; D011613:Psychotherapy / Q000379:methods*; D012649:Self Concept; D012657:Self-Help Groups / Q000706:statistics & numerical data; D016896:Treatment Outcome; D015431:Weight Loss