Placental thrombomodulin expression in recurrent miscarriage.
BACKGROUND
Early pregnancy loss can be associated with trophoblast insufficiency and coagulation defects. Thrombomodulin is an endothelial-associated anticoagulant protein involved in the control of hemostasis and inflammation at the vascular beds and it's also a cofactor of the protein C anticoagulant pathway.


CONCLUSIONS
We evaluate the Thrombomodulin expression in placental tissue from spontaneous recurrent miscarriage and voluntary abortion as controls. Thrombomodulin mRNA was determined using real-time quantitative polymerase chain reaction. Reduced expression levels of thrombomodulin were found in recurrent miscarriage group compared to controls (1.82-fold of reduction), that corresponds to a reduction of 45% (from control group Delta CT) of thrombomodulin expression in spontaneous miscarriage group respect the control groups.


CONCLUSIONS
We cannot state at present the exact meaning of a reduced expression of Thrombomodulin in placental tissue. Further studies are needed to elucidate the biological pathway of this important factor in the physiopathology of the trophoblast and in reproductive biology.
Stortoni
Piergiorgio
P
Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy.
Cecati
Monia
M
Giannubilo
Stefano R
SR
Sartini
Davide
D
Turi
Angelo
A
Emanuelli
Monica
M
Tranquilli
Andrea L
AL
D000026:Abortion, Habitual / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D015536:Down-Regulation / Q000235:genetics; D005260:Female; D015870:Gene Expression; D005865:Gestational Age; D006801:Humans; D010920:Placenta / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D018180:Thrombomodulin / Q000235:genetics* / Q000378:metabolism
C546931:THBD protein, human; D018180:Thrombomodulin