title: Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma.
abstract: We analyzed the expression of Id-1 in oral squamous cell carcinoma (OSCC) immunohistochemically, and investigated the association of Id-1 expression with tumor angiogenesis and clinical prognosis. Overexpression of Id-1 protein was found in 83 out of 128 cases (64.8%). The expression of Id-1 was significantly associated with tumor size (p=0.013), lymph node metastasis (p=0.001), tumor stage (p=0.031) and tumor recurrence (p=0.003). Moreover, Id-1 expression was significantly correlated with intratumoral microvessel density (MVD) (r=0.223, p=0.011). The results suggest that overexpression of Id-1 was correlated with tumor angiogenesis and poor clinical outcome.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, PR China.
authors.forename: Zuoqing
authors.initials: Z
authors.lastname: Dong
authors.forename: Shaohua
authors.initials: S
authors.lastname: Liu
authors.forename: Chengjun
authors.initials: C
authors.lastname: Zhou
authors.forename: Tomoki
authors.initials: T
authors.lastname: Sumida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hamakawa
authors.forename: Zhenggang
authors.initials: Z
authors.lastname: Chen
authors.forename: Pei
authors.initials: P
authors.lastname: Liu
authors.forename: Fengcai
authors.initials: F
authors.lastname: Wei
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D051798:Inhibitor of Differentiation Protein 1 / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000098:blood supply / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome; D047368:Tumor Burden; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: C497453:ID1 protein, human; D051798:Inhibitor of Differentiation Protein 1; D042461:Vascular Endothelial Growth Factor A