title: A regenerative strategy for heart failure in hypoplastic left heart syndrome: intracoronary administration of autologous bone marrow-derived progenitor cells.
abstract: Novel surgical strategies have dramatically improved the initial outcome of newborns with hypoplastic left heart syndrome. However, the single systemic right ventricle remains a major challenge, with limited effectiveness of pharmacologic therapy. The present case documents that the intracoronary administration of autologous bone marrow-derived progenitor cells is technically feasible in a critically ill infant with hypoplastic left heart syndrome and severe heart failure after a hybrid comprehensive stage II procedure. Cell therapy might represent an option before heart transplantation in children with single ventricle physiology presenting with severe heart failure.
authors.affiliation: Pediatric Heart Center, Justus-Liebig University Giessen, Giessen, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Rupp
authors.forename: Andreas M
authors.initials: AM
authors.lastname: Zeiher
authors.forename: Stefanie
authors.initials: S
authors.lastname: Dimmeler
authors.forename: Torsten
authors.initials: T
authors.lastname: Tonn
authors.forename: Juergen
authors.initials: J
authors.lastname: Bauer
authors.forename: Christian
authors.initials: C
authors.lastname: Jux
authors.forename: Hakan
authors.initials: H
authors.lastname: Akintuerk
authors.forename: Dietmar
authors.initials: D
authors.lastname: Schranz
mesh_terms: D016026:Bone Marrow Transplantation; D006328:Cardiac Catheterization; D057176:Compassionate Use Trials; D004452:Echocardiography; D005240:Feasibility Studies; D005500:Follow-Up Studies; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000503:physiopathology / Q000628:therapy*; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D011183:Postoperative Complications / Q000503:physiopathology; D012038:Regeneration / Q000502:physiology*; D012086:Reoperation; D033581:Stem Cell Transplantation