Square pyramidal copper(II) complexes with forth generation fluoroquinolone and neutral bidentate ligand: structure, antibacterial, SOD mimic and DNA-interaction studies.
Coordination of neutral bidentate ligand to copper ion in combination with gatifloxacin have been focused in this article. The effect of complexation reflects antibacterial activity, DNA interaction and SOD mimic activity of individual greatly. The geometry at the central metal ion provides a site for binding of superoxide anion responsible for better SOD mimic behaviour.
Patel
Mohan N
MN
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India. jeenen@gmail.com
Parmar
Pradhuman A
PA
Gandhi
Deepen S
DS
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D024841:Fluoroquinolones / Q000737:chemistry* / Q000494:pharmacology*; D000077734:Gatifloxacin; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D013053:Spectrophotometry; D013055:Spectrophotometry, Infrared; D013481:Superoxides / Q000378:metabolism
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D013481:Superoxides; D003300:Copper; D004247:DNA; D000077734:Gatifloxacin