title: Effect of glycerophospholipid class on the beta-carotene uptake by human intestinal Caco-2 cells.
abstract: The effects were evaluated of various glycerophospholipids on the uptake of beta-carotene solubilized in mixed micelles by human intestinal Caco-2 cells. Phosphatidylethanolamine markedly enhanced the transfer of beta-carotene from the micelles to the cells, whereas phosphatidylcholine suppressed it. All the lysoglycerophospholipids enhanced the transfer, irrespective of the polar head group. Glycerophospholipids therefore have the potential to modify the intestinal absorption of carotenoids.
authors.affiliation: National Food Research Institute, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Kotake-Nara
authors.forename: Lina
authors.initials: L
authors.lastname: Yonekura
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nagao
mesh_terms: D001692:Biological Transport / Q000187:drug effects; D018938:Caco-2 Cells; D020404:Glycerophospholipids / Q000145:classification* / Q000494:pharmacology*; D006801:Humans; D008823:Micelles; D012995:Solubility; D019207:beta Carotene / Q000737:chemistry / Q000378:metabolism*
chemical_list: D020404:Glycerophospholipids; D008823:Micelles; D019207:beta Carotene