title: Auditory hallucinations in schizophrenia are associated with reduced functional connectivity of the temporo-parietal area.
abstract: BACKGROUND
  Schizophrenia has been conceptualized as a disorder of integration of neural activity across distributed networks. However, the relationship between specific symptom dimensions and patterns of functional connectivity remains unclear. The current study aimed to investigate the relationship between auditory-verbal hallucinations (AVH), a particularly prevalent and clinically relevant symptom in schizophrenia, and functional connectivity of the temporo-parietal junction (TPJ).
  
  
  METHODS
  Resting state functional magnetic resonance imaging scans were obtained from 27 schizophrenia patients with AVH and 27 matched control subjects. We calculated correlations reflecting functional connectivity between a priori defined regions-of-interest and the bilateral TPJ seed regions, comprising the neural network involved in inner speech processes and AVH.
  
  
  RESULTS
  Compared with healthy control subjects, schizophrenia patients showed reduced functional connectivity between left TPJ and the right homotope of Broca. Within the patient group, more severe AVH were associated with reduced neural coupling between left TPJ and bilateral anterior cingulate as well as the bilateral amygdala.
  
  
  CONCLUSIONS
  In schizophrenia patients with chronic hallucinations, the left TPJ-a critical node in the speech perception/AVH network-shows reduced functional connectivity with brain areas involved in the attribution of agency, self-referent processing, and attentional control.
authors.affiliation: Department of Neuroscience, University Medical Center Groningen, BCN Neuroimaging Center, University of Groningen, The Netherlands. a.vercammen@med.umcg.nl
authors.forename: Ans
authors.initials: A
authors.lastname: Vercammen
authors.forename: Henderikus
authors.initials: H
authors.lastname: Knegtering
authors.forename: Johann A
authors.initials: JA
authors.lastname: den Boer
authors.forename: Edith J
authors.initials: EJ
authors.lastname: Liemburg
authors.forename: André
authors.initials: A
authors.lastname: Aleman
mesh_terms: D000328:Adult; D005260:Female; D006212:Hallucinations / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology*; D010296:Parietal Lobe / Q000503:physiopathology*; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013067:Speech Perception / Q000502:physiology; D013702:Temporal Lobe / Q000503:physiopathology*