Neurological condition of infants born after in vitro fertilization with preimplantation genetic screening.
Aim of this study was to evaluate the effect of preimplantation genetic screening (PGS) on neurodevelopmental outcome in children. We conducted a prospective follow-up study of children born to women randomly assigned to in vitro fertilization with or without PGS. Primary outcome was adverse neurologic outcome at 18 mo; secondary outcomes were types of minor neurologic dysfunction (MND), neurologic outcome before 18 mo, neonatal intensive care admission, and congenital malformations. Twenty women in the PGS group participated with 25 children and 26 women in the control group participated with 31 children. Five PGS pregnancies (25%) and four control pregnancies (15%) resulted in birth of at least one child with an adverse neurologic outcome (adjusted odds ratio: 2.3 [0.4-12.0]). Dysfunction in fine motor abilities and posture and muscle tone dysregulation tended to be present more frequently after PGS. Neurologic outcome before 18 mo, neonatal intensive care admission, and prevalence of congenital malformations were similar in study and control pregnancies. Nevertheless, at child level, rates of adverse outcome were higher after PGS. In conclusion, outcome in pregnancies after in vitro fertilization (IVF) with and without PGS was similar. The small sample size precludes the conclusion that PGS is not associated with less favorable neurologic outcome. Safety of new assisted reproductive techniques should be evaluated before large-scale implementation.


BACKGROUND
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Middelburg
Karin J
KJ
Departments of Pediatrics, University Medical Center Groningen, The Netherlands. k.j.middelburg@developmentalneurology.com
Heineman
Maas J
MJ
Haadsma
Maaike L
ML
Bos
Arend F
AF
Kok
Joke H
JH
Hadders-Algra
Mijna
M
D005307:Fertilization in Vitro; D005817:Genetic Counseling; D006801:Humans; D007231:Infant, Newborn; D009424:Nervous System Physiological Phenomena; D019836:Preimplantation Diagnosis