A regenerative strategy for heart failure in hypoplastic left heart syndrome: intracoronary administration of autologous bone marrow-derived progenitor cells.
Novel surgical strategies have dramatically improved the initial outcome of newborns with hypoplastic left heart syndrome. However, the single systemic right ventricle remains a major challenge, with limited effectiveness of pharmacologic therapy. The present case documents that the intracoronary administration of autologous bone marrow-derived progenitor cells is technically feasible in a critically ill infant with hypoplastic left heart syndrome and severe heart failure after a hybrid comprehensive stage II procedure. Cell therapy might represent an option before heart transplantation in children with single ventricle physiology presenting with severe heart failure.
Rupp
Stefan
S
Pediatric Heart Center, Justus-Liebig University Giessen, Giessen, Germany.
Zeiher
Andreas M
AM
Dimmeler
Stefanie
S
Tonn
Torsten
T
Bauer
Juergen
J
Jux
Christian
C
Akintuerk
Hakan
H
Schranz
Dietmar
D
D016026:Bone Marrow Transplantation; D006328:Cardiac Catheterization; D057176:Compassionate Use Trials; D004452:Echocardiography; D005240:Feasibility Studies; D005500:Follow-Up Studies; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000503:physiopathology / Q000628:therapy*; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D011183:Postoperative Complications / Q000503:physiopathology; D012038:Regeneration / Q000502:physiology*; D012086:Reoperation; D033581:Stem Cell Transplantation