[Study on the preparation of sustained-release pellets containing active components from Gastrodia elata by fluid-bed coating].
OBJECTIVE
To study the formulation of sustained-release pellets containing active components from Gastrodia elata by coating in the fluid-bed.


METHODS
The sustained-release pellets were prepared with Eudragit RS 100. The formulation was optimized by the direct comparison. Then their properties were evaluated.


RESULTS
The pellets presented the perfect sphericity and narrow diameter distribution and the curve of their cumulative drug release was in accord with Higuchi equation.


CONCLUSIONS
The pellets have sustained-release effect in 12 hours.
Hong
Yan-long
YL
Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of TCM, Shanghai 201203, China. hfuir@163.com
Lin
Xiao
X
Xu
De-sheng
DS
Feng
Yi
Y
Li
Jun-song
JS
Zhang
Ya-jun
YJ
D000180:Acrylic Resins; D001592:Benzyl Alcohols / Q000032:analysis / Q000737:chemistry* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000493:pharmacokinetics; D031668:Gastrodia / Q000737:chemistry*; D005960:Glucosides / Q000032:analysis / Q000737:chemistry* / Q000493:pharmacokinetics; D008863:Microspheres; D010946:Plants, Medicinal / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*
D000180:Acrylic Resins; D001592:Benzyl Alcohols; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D011108:Polymers; C050528:Eudragit RS; C045345:gastrodin