Dammarane-type saponins from the flower buds of Panax ginseng and their intracellular radical scavenging capacity.
Korean ginseng (Panax ginseng C.A. Meyer) has been extensively used as a functional food for thousands of years. This study with the aim to evaluate the potential of P. ginseng flower components as a functional food with medicinal properties resulted in the identification of three new dammarane-type saponins, named floralginsenosides Ka-Kc (1-3), along with seventeen known ones (4-20). Their structures were elucidated on the basis of chemical and spectroscopic methods, and their antioxidant activities were evaluated by the intracellular ROS radical scavenging DCF-DA assay. Among them, floralginsenoside Ka (1) displayed potent scavenging activity with the inhibition value of 64% at 10 microM; and ginsenoside Rb(1) (13), floralginsenoside Kc (3), floralginsenoside Kb (2), vinaginsenoside R(9) (11), majoroside F(1) (12), ginsenoside I (17), and ginsenoside II (18) showed moderate scavenging capacity with the inhibition rate of 28, 33, 35, 35, 35, 38, and 38% at 10 microM, respectively. These results warrant further studies concerning the potential of saponin extracts of P. ginseng flowers for functional foods.
Tung
Nguyen Huu
NH
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
Song
Gyu Yong
GY
Nhiem
Nguyen Xuan
NX
Ding
Yan
Y
Tai
Bui Huu
BH
Jin
Long Guo
LG
Lim
Chae-Moon
CM
Hyun
Jin Won
JW
Park
Chun Jung
CJ
Kang
Hee Kyoung
HK
Kim
Young Ho
YH
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D035264:Flowers / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000494:pharmacology; D042541:Intracellular Space / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D005894:Panax / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D012503:Saponins