[Advances in the study of organelles targeting nanocarriers].
Modern drug delivery system demands high therapeutic efficacy and low toxicity which depends on efficient intracellular transportation of therapeutics to specific organisms, cells, even targeted organelles such as cytosol, nucleus, mitochondria, lysosome and endoplasmic reticulum. Intracellular barriers which prevent drug molecules accessing to their targets mainly include cell membrane, lysosomal degradation and the endomembrane system. Nanocarriers can preserve the bioactivities of protein, enzyme and DNA, and also they are easy to be modified and functionalized. In this paper, we summarized the intracellular fate of nanocarriers, especially how to bypass intracellular barriers and then target cytosol, nucleus, mitochondria, lysosome and endoplasmic reticulum by pharmaceutical modifications.
Sun
Xiao-Yi
XY
Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Wei
Li-Li
LL
Chen
Hai-Liang
HL
Liang
Wen-Quan
WQ
D000818:Animals; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles; D015388:Organelles
D004337:Drug Carriers