Acute encephalopathy associated with influenza A infection in adults.
We report acute encephalopathy associated with influenza A infection in 3 adults. We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios > or =3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. Patients recovered without sequelae. Hyperactivated cytokine response may play a role in pathogenesis.
Lee
Nelson
N
Division of Infectious Diseases, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 9/F Clinical Sciences Building, Department of Medicine and Therapeutics, Shatin, Hong Kong, People's Republic of China. leelsn@cuhk.edu.hk
Wong
Chun Kwok
CK
Chan
Paul K S
PK
Lindegardh
Niklas
N
White
Nicholas J
NJ
Hayden
Frederick G
FG
Wong
Edward H C
EH
Wong
Ka Shing
KS
Cockram
Clive S
CS
Sung
Joseph J Y
JJ
Hui
David S C
DS
D000368:Aged; D000369:Aged, 80 and over; D016207:Cytokines / Q000502:physiology; D018792:Encephalitis, Viral / Q000150:complications / Q000821:virology*; D005260:Female; D006801:Humans; D009980:Influenza A virus; D007251:Influenza, Human / Q000150:complications / Q000821:virology*; D008297:Male
D016207:Cytokines