Chemokine polymorphisms and lymphoma: a pooled analysis.
Polymorphisms in chemokine genes have been associated with human immunodeficiency virus (HIV)-related non-Hodgkin lymphoma (NHL) but are understudied in non-HIV-related NHL. Associations of NHL and NHL subtypes with polymorphisms and haplotypes in CCR5, CCR2, CCL5, CXCL12, and CX(3)CR(1) were explored in a pooled analysis of three case-control studies (San Francisco Bay Area, California; United Kingdom; total: cases N = 1610, controls N = 1992). Adjusted unconditional logistic regression was used to estimate relative risks among HIV-negative non-Hispanic Caucasians. The CCR5 Delta32 deletion reduced the risk of NHL (odds ratio = 0.56, 95% confidence interval = 0.38-0.83) in men but not women with similar effects observed for diffuse large-cell and follicular lymphoma (FL). NHL risk also was reduced in men with the CCR2/CCR5 haplotype characterized by the CCR5 Delta32 deletion. The CCL5 -403A allele conferred reduced risks of FL and chronic lymphocytic leukemia/small lymphocytic lymphoma. Results should be interpreted conservatively. Continued investigation is warranted to confirm these findings.
Bracci
Paige M
PM
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94118-1944, USA. paige.bracci@ucsf.edu
Skibola
Christine F
CF
Conde
Lucia
L
Halperin
Eran
E
Lightfoot
Tracy
T
Smith
Alex
A
Paynter
Randi A
RA
Skibola
Danica R
DR
Agana
Luz
L
Roman
Eve
E
Kane
Eleanor
E
Wiencke
John K
JK
D000293:Adolescent; D000328:Adult; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006239:Haplotypes; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics; D008223:Lymphoma / Q000235:genetics* / Q000378:metabolism*; D008224:Lymphoma, Follicular / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012044:Regression Analysis