Putative association of DNA methyltransferase 1 (DNMT1) polymorphisms with clearance of HBV infection.
DNA methyltransferase (DNMT) 1 is the key enzyme responsible for DNA methylation, which often occurs in CpG islands located near the regulatory regions of genes and affects transcription of specific genes. In this study, we examined the possible association of DNMT1 polymorphisms with HBV clearance and the risk of hepatocellular carcinoma (HCC). Seven common polymorphic sites were selected by considering their allele frequencies, haplotype-tagging status and LDs for genotyping in larger-scale subjects (n = 1,100). Statistical analysis demonstrated that two intron polymorphisms of DNMT1, +34542G > C and +38565G > T, showed significant association with HBV clearance in a co-dominant model (OR = 1.30, P(corr) = 0.03) and co- dominant/recessive model (OR = 1.34-1.74, P(corr) = 0.01-0.03), respectively. These results suggest that two intron polymorphisms of DNMT1,+34542G > C and +38565G > T, might affect HBV clearance.
Chun
Ji Yong
JY
Department of Life Science, Sogang University, Seoul 121-742, Korea.
Bae
Joon Seol
JS
Park
Tae June
TJ
Kim
Jason Y
JY
Park
Byung Lae
BL
Cheong
Hyun Sub
HS
Lee
Hyo Suk
HS
Kim
Yoon Jun
YJ
Shin
Hyoung Doo
HD
D006528:Carcinoma, Hepatocellular / Q000201:enzymology / Q000235:genetics* / Q000821:virology; D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000201:enzymology / Q000235:genetics* / Q000821:virology*; D006515:Hepatitis B virus / Q000502:physiology*; D006801:Humans; D008113:Liver Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000821:virology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases; C000619380:DNMT1 protein, human