title: [Practical research in morbid condition due to exogenous invasions for application in forensic diagnosis and preventive medical treatment].
abstract: We report research subjects on the morbid conditions due to various exogenous invasions, iatrogenic damages and suicide. The studies of morbid condition by exogenous invasions are as follows : 1) forensic significance of endocardial bleeding to diagnosing the causes of death, 2) forensic implication of intramuscular bleeding of the tongue of the fire victims, 3) stability of cyanide concentration in blood of the fire victims and the evaluation of the toxic potential, 4) histochemical detection of ABO blood type of the muscle of the fire victims by signal amplification method with biotinylated tyramide, 5) alcohol detection of purified brain tissue of the drowned victims and the estimation of the amount of drinking, and 6) investigation into unclosing a mechanism of postmortem production of endogenous gamma-hydroxybutyric acid(GHB). The researches for iatrogenic damages are as follows: 1) iatrogenic ribs fracture due to chest compression during cardiopulmonary resuscitation, 2) bone marrow embolism of the lung caused by iatrogenic ribs fracture, and 3) forensic application of lidocaine of blood and tissues, which is derived from xylocaine jelly, chemicals for surface anesthesia, frequently used with the purpose of lubricating effect when intubation tube is introduced into the trachea. The issues of suicide research aiming forensic and clinical application are as follows: 1) forensic significance of blood nicotine levels of the smokers who committed suicide, 2) forensic availability of muscle nicotine levels of the purified bodies who have suspected suicide, and 3) forensic value of analysis of chromogranin A mRNA in autopsy cases with various cause of death to diagnosing suicide.
authors.affiliation: Department of Legal Medicine, Kochi Medical School, Kochi University, Kochi 783-8505, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Hashimoto
mesh_terms: D018732:Forensic Anthropology; D005554:Forensic Medicine / Q000379:methods; D006801:Humans; D007049:Iatrogenic Disease; D011041:Poisoning; D013405:Suicide