title: Validation of a novel automated border-detection algorithm for rapid and accurate quantitation of left ventricular volumes based on three-dimensional echocardiography.
abstract: OBJECTIVE
  To assess the accuracy and reproducibility of a novel automated software for left ventricular (LV) volumes and ejection fraction (EF) measurements using real-time three-dimensional echocardiography (3DE).
  
  
  RESULTS
  A total of 103 patients with a wide range of LV volumes were analyzed with both 4D AutoLVQ and 4D TomTec software. In 23 patients, a side-by-side comparison of LV volume and EF measurements was done between 3DE, 2DE, and cardiac magnetic resonance (CMR). Excellent correlation was found between 4D AutoLVQ and 4D TomTec [r = 0.98 for end-diastolic volume (EDV), 0.99 for end-systolic volume (ESV), and 0.97 for EF, P < 0.0001], with small biases and narrow limits of agreement: EDV 5.2 mL (-14 to 25 mL), ESV 2.9 mL (-10 to 16 mL), EF -0.2% (-7 to 6%). Time of analysis was halved using 4D AutoLVQ with manual correction (1 min 52 s+/- 30 s) in comparison with 4D TomTec software (3 min 46 s +/- 1 min 24 s). Both softwares showed similar accuracy in comparison with CMR (4D AutoLVQ biases -11.0 mL, -9.1 mL, and 2.9%; 4D TomTec biases -8.3 mL, -7.4 mL, and 2.8% for EDV, ESV, and EF, respectively, P = NS for all) and good reproducibility.
  
  
  CONCLUSIONS
  Novel 4D AutoLVQ software showed very good agreement with more time-consuming 4D TomTec software, having similar accuracy against CMR.
authors.affiliation: Professor Dr C.C. Iliescu Institute of Cardiovascular Diseases, Sos. Fundeni, 258, Sector 2, 022322 Bucharest, Romania. denisa.muraru@gmail.com
authors.forename: Denisa
authors.initials: D
authors.lastname: Muraru
authors.forename: Luigi P
authors.initials: LP
authors.lastname: Badano
authors.forename: Gianluca
authors.initials: G
authors.lastname: Piccoli
authors.forename: Pasquale
authors.initials: P
authors.lastname: Gianfagna
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Del Mestre
authors.forename: Davide
authors.initials: D
authors.lastname: Ermacora
authors.forename: Alessandro
authors.initials: A
authors.lastname: Proclemer
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D019560:Echocardiography, Three-Dimensional; D005260:Female; D006352:Heart Ventricles / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D015203:Reproducibility of Results; D012984:Software; D013318:Stroke Volume