Metalloproteinases and their regulators in colorectal cancer.
Metalloproteinases (MPs) such as the matrix metalloproteinases (MMPs) and adamalysins (ADAMs and ADAMTS) are expressed in various stages of colorectal cancer (CRC), and some correlate with survival and prognosis. The MPs are regulated by various factors including EMMPRIN, TIMPs, and RECK. In addition, micro-RNAs are found to be relevant for both MP expression levels and CRC prognostication. Both MPs and their regulators could be potential targets for intervention and therapy in CRC.
van der Jagt
Michel F P
MF
Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
Wobbes
Theo
T
Strobbe
Luc J A
LJ
Sweep
Fred C G J
FC
Span
Paul N
PN
D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000209:etiology; D004789:Enzyme Activation; D058851:GPI-Linked Proteins; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology; D008666:Metalloendopeptidases / Q000502:physiology; D045726:Metalloproteases / Q000235:genetics / Q000502:physiology*; D035683:MicroRNAs / Q000502:physiology; D019714:Tissue Inhibitor of Metalloproteinases / Q000502:physiology
D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; D035683:MicroRNAs; C115460:RECK protein, human; D019714:Tissue Inhibitor of Metalloproteinases; D045726:Metalloproteases; D008666:Metalloendopeptidases; C028220:Crotalus adamanteus proteinase II