title: [A case of far-advanced gastric cancer with peritoneal dissemination and obstructive jaundice effectively treated with combination chemotherapy and interventional radiology].
abstract: A 70-year-old man was hospitalized for obstructive jaundice. Endoscopic examination disclosed Borrmann type 3 advanced gastric cancer from ECJ to the middle corpus. Laparoscopic examination demonstrated the disseminated nodules at hepatic hilum. After percutaneous biliay drainage, we implanted an expandable metallic stent utilizing this fistula and started combination chemotherapy with S-1 and CDDP. Although a partial response was achieved at endoscopic examination after 4 cycles, gastric and biliary legions gradually showed tolerance to S-1 and CDDP. We attempted 3 cycles of weekly paclitaxel as second-line. However, paclitaxel was not effective, the patient died of cancer growth 12 months after the first admission. According to combination with IVR and chemotherapy, we treated effectively the patient suffering from far-advanced gastric cancer with peritoneal dissemination and obstructive jaundice.
authors.affiliation: Department of Hepato-Gastrointestinal Surgery, Odawara Municipal Hospital.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kametaka
authors.forename: Hironobu
authors.initials: H
authors.lastname: Makino
authors.forename: Takashi
authors.initials: T
authors.lastname: Koyama
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Seike
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004338:Drug Combinations; D006801:Humans; D041781:Jaundice, Obstructive / Q000209:etiology*; D008297:Male; D009366:Neoplasm Seeding; D010094:Oxonic Acid / Q000008:administration & dosage; D010534:Peritoneal Neoplasms / Q000150:complications*; D015641:Radiography, Interventional; D013274:Stomach Neoplasms / Q000473:pathology* / Q000628:therapy*; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin