Fish oil supplementation decreases serum soluble receptor activator of nuclear factor-kappa B ligand/osteoprotegerin ratio in female patients with rheumatoid arthritis.
OBJECTIVE
Soluble receptor activator of nuclear factor-kappa B ligand (sRANKL) to osteoprotegerin ratio is designated as a bone metabolism equation in many rheumatologic disorders and would be modified with fish oil (FO) supplementation.


METHODS
Eighty-three females with rheumatoid arthritis were divided randomly to 40 and 43 patients treated with (1 g/day) or without FO for 3 months accompanied with conventional drugs, respectively. Osteoprotegerin, sRANKL, tumor necrosis factor alpha (TNFalpha) serum levels were measured before and after treatment.


RESULTS
Serum levels of osteoprotegerin increased, although sRANKL, TNFalpha and sRANKL/osteoprotegerin ratio decreased with FO therapy. A significant positive correlation was observed between sRANKL/osteoprotegerin ratio and TNFalpha levels (r=0.327, p=0.040) in the FO-treated group.


CONCLUSIONS
FO could decrease the inflammatory response by lowering of serum TNFalpha levels and sRANKL/osteoprotegerin ratio.
Kolahi
Sousan
S
Biochemistry Laboratory, Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Ghorbanihaghjo
Amir
A
Alizadeh
Samira
S
Rashtchizadeh
Nadereh
N
Argani
Hassan
H
Khabazzi
Ali-Reza
AR
Hajialilo
Mehrzad
M
Bahreini
Elham
E
D000293:Adolescent; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000178:diet therapy; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D019587:Dietary Supplements; D004311:Double-Blind Method; D015536:Down-Regulation / Q000187:drug effects; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D053244:Osteoprotegerin / Q000097:blood*; D010919:Placebos; D053245:RANK Ligand / Q000097:blood*; D012995:Solubility; D055815:Young Adult
D005395:Fish Oils; D053244:Osteoprotegerin; D010919:Placebos; D053245:RANK Ligand; C506030:TNFRSF11B protein, human