VEGF mRNA expression in jugulotympanic paraganglioma.
The vascular endothelial growth factor (VEGF) family are essential regulators of angiogenesis and vascular permeability. VEGF protein was found in the jugulotympanic paraganglioma, but it wasn't confirmed on mRNA level. Our aim of this study is the mRNA expression of VEGF in jugulotympanic paraganglioma. We chose six cases of primary jugulotympanic paraganglioma wax specimen by hybridisation in situ. It suggested that VEGF mRNA had significant expression in the tumour cytoplasm of jugulotympanic paraganglioma. The correlation is not yet clear. It could be suggested the higher degree of malignancy, the stronger expression of VEGF mRNA in cytoplasm, but not found in the cellular nucleus.
Zhang
X
X
Department of ENT, Anhui provincial Hospital, Anhui Medical University, Hefei, Anhui, China.
Xu
W
W
Sun
J
J
Zhang
K
K
D000328:Adult; D003593:Cytoplasm / Q000378:metabolism; D004428:Ear Neoplasms / Q000378:metabolism* / Q000473:pathology; D005925:Glomus Jugulare Tumor / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D017403:In Situ Hybridization; D012333:RNA, Messenger / Q000378:metabolism*; D042442:Vascular Endothelial Growth Factors / Q000235:genetics / Q000378:metabolism*
D012333:RNA, Messenger; D042442:Vascular Endothelial Growth Factors