Kinins in cardiac inflammation and regeneration: insights from ischemic and diabetic cardiomyopathy.
The kallikrein-kinin system (KKS) is a system of vasoactive peptides, the kinins, involved in different aspects of remodeling, inflammation and angiogenesis. Kinins mediate their actions through two receptors, B1R and B2R. It is increasingly recognized that the KKS is involved in the inflammatory processes of the heart. Evidence shows that the B2R is beneficial in myocardial diseases, protecting from inflammation, fibrosis and apoptosis, while B1R shows a proinflammatory character contributing to the disease progression by increasing the production of cytokines and stimulating the migration of immune cells. Furthermore, novel important actions of the KKS and its receptors contribute to neovascularization and recruitment of endothelial progenitor cells in ischemic areas and endothelial dysfunction. The kinin receptors could therefore constitute potential therapeutic targets in the treatment of myocardial ischemia and diabetic cardiomyopathy.
Savvatis
Konstantinos
K
Charité - Universitätsmedizin Berlin, Department of Cardiology and Pneumonology, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany.
Westermann
Dirk
D
Schultheiss
Heinz-Peter
HP
Tschöpe
Carsten
C
D009202:Cardiomyopathies / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D016234:Kallikrein-Kinin System / Q000502:physiology; D007610:Kallikreins / Q000378:metabolism; D007705:Kinins / Q000378:metabolism*; D017202:Myocardial Ischemia / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000378:metabolism; D012038:Regeneration
D007705:Kinins; D007610:Kallikreins