Lack of knowledge of hormone receptor status and use of endocrine therapy in invasive breast cancer.
OBJECTIVE
The aim of this study was to investigate the level of understanding in women with newly diagnosed invasive breast cancer of the key clinical features of their disease that are important determinants in treatment decision making.


METHODS
The 1684 women aged between 26 and 88 years at diagnosis enrolled in a 5-year cohort study were asked by questionnaire about their estrogen receptor (ER) and progesterone receptor (PR) status and about their past or current treatment with adjuvant endocrine therapy. Information was linked with their ER and PR status determined from the histopathology report. Logistic regression analysis was used to explore the relationship between age and education status and the likelihood of being able to correctly report hormone receptor status, as well as the relationship between the likelihood of receiving adjuvant endocrine therapy and knowledge of hormone receptor status in women who were ER or PR positive.


RESULTS
Not being able to correctly report hormone receptor status was associated with being older and having a lower level of education. Of women who were ER positive or PR positive or both and were at least 40 weeks from diagnosis, having received some form of endocrine therapy was significantly associated with self-identification as being ER or PR positive (OR=1.82, 95% CI 1.24-2.68, p=0.002), even when age was taken into account.


CONCLUSIONS
That self-knowledge of hormone receptor status was independently associated with likelihood of receiving endocrine therapy suggests that the methods of helping women understand the nature of their breast cancer are worthy of review.
Bell
Robin J
RJ
Women's Health Program, Department of Medicine, Monash Medical School, Monash University, Alfred Hospital, Prahan, Victoria, Australia. robin.bell@med.monash.edu.au
Lijovic
Marijana
M
Fradkin
Pam
P
Bradbury
Jo
J
La China
Maria
M
Schwarz
Max
M
Wolfe
Rory
R
Farrugia
Helen
H
Davis
Susan R
SR
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000453:epidemiology* / Q000378:metabolism / Q000523:psychology; D015914:Estrogen Replacement Therapy / Q000379:methods* / Q000523:psychology; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D016387:Women's Health
D018931:Antineoplastic Agents, Hormonal; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone