1-Arylsulfonyl-2-(pyridylmethylsulfinyl) benzimidazoles as new proton pump inhibitor prodrugs.
New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.
Shin
Jai Moo
JM
Department of Physiology, David Geffen School of Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA. jaishin@ucla.edu
Sachs
George
G
Cho
Young-moon
YM
Garst
Michael
M
D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D001769:Blood; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology*; D054328:Proton Pump Inhibitors / Q000737:chemistry / Q000494:pharmacology*
D001562:Benzimidazoles; D011355:Prodrugs; D054328:Proton Pump Inhibitors