Multi-scale heat and mass transfer modelling of cell and tissue cryopreservation.
Cells and tissues undergo complex physical processes during cryopreservation. Understanding the underlying physical phenomena is critical to improve current cryopreservation methods and to develop new techniques. Here, we describe multi-scale approaches for modelling cell and tissue cryopreservation including heat transfer at macroscale level, crystallization, cell volume change and mass transport across cell membranes at microscale level. These multi-scale approaches allow us to study cell and tissue cryopreservation.
Xu
Feng
F
Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Moon
Sangjun
S
Zhang
Xiaohui
X
Shao
Lei
L
Song
Young Seok
YS
Demirci
Utkan
U
D000818:Animals; D001831:Body Temperature / Q000502:physiology*; D002468:Cell Physiological Phenomena; D003198:Computer Simulation; D015925:Cryopreservation; D004735:Energy Transfer / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D013696:Temperature; D013814:Thermal Conductivity