Transcription factor, SP1, in epiretinal membranes of patients with proliferative diabetic retinopathy.
SP1 mRNA was highly expressed in the epiretinal membranes of proliferative diabetic retinopathy (PDR), and the SP1 protein was mainly co-localized with vascular endothelial growth factor. SP1 might play an important role in the angiogenesis of PDR by regulating the promoter activity and expression of genes encoding angiogenesis-related factors.
Yoshida-Hata
Natsuyo
N
Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Chiba, Japan.
Mitamura
Yoshinori
Y
Oshitari
Toshiyuki
T
Namekata
Kazuhiko
K
Harada
Chikako
C
Harada
Takayuki
T
Yamamoto
Shuichi
S
D003930:Diabetic Retinopathy / Q000235:genetics* / Q000378:metabolism; D019773:Epiretinal Membrane / Q000235:genetics / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006801:Humans; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012160:Retina / Q000378:metabolism*; D012171:Retinal Vessels / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016329:Sp1 Transcription Factor / Q000235:genetics* / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
D012333:RNA, Messenger; D016329:Sp1 Transcription Factor; D042461:Vascular Endothelial Growth Factor A