Poly(DL-lactide)-b-poly(N,N-dimethylamino-2-ethyl methacrylate): synthesis, characterization, micellization behavior in aqueous solutions, and encapsulation of the hydrophobic drug dipyridamole.
We synthesized a series of well-defined poly(dl-lactide)-b-poly(N,N-dimethylamino-2-ethyl methacrylate) (PDLLA-b-PDMAEMA) amphiphilic diblock copolymers by employing a three-step procedure: (a) ring-opening polymerization (ROP) of dl-lactide using n-decanol and stannous octoate, Sn(Oct)(2), as the initiating system, (b) reaction of the PDLLA hydroxyl end groups with bromoisobutyryl bromide, and (c) atom transfer radical polymerization, ATRP, of DMAEMA with the newly created bromoisobutyryl initiating site. The aggregation behavior of the prepared block copolymers was investigated by dynamic light scattering and zeta potential measurements at 25 degrees C in aqueous solutions of different pH values. The hydrophobic drug dipyridamole was efficiently incorporated into the copolymer aggregates in aqueous solutions of pH 7.40. High partition coefficient values were determined by fluorescence spectroscopy.
Karanikolopoulos
Nikos
N
Department of Chemistry, University of Athens, Greece.
Zamurovic
Miljana
M
Pitsikalis
Marinos
M
Hadjichristidis
Nikos
N
D004176:Dipyridamole / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000138:chemical synthesis / Q000493:pharmacokinetics; D057927:Hydrophobic and Hydrophilic Interactions; D008689:Methacrylates / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D008823:Micelles; D009757:Nylons / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D019999:Pharmaceutical Solutions / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011091:Polyesters / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D014867:Water / Q000737:chemistry / Q000378:metabolism
D004337:Drug Carriers; D008689:Methacrylates; D008823:Micelles; D009757:Nylons; D019999:Pharmaceutical Solutions; D011091:Polyesters; C407037:poly(2-(dimethylamino)ethyl methacrylate); D014867:Water; C033616:poly(lactide); D004176:Dipyridamole