title: A 30-year perspective (1975-2005) into the changing landscape of patients hospitalized with initial acute myocardial infarction: Worcester Heart Attack Study.
abstract: BACKGROUND
  The effects of lifestyle changes and evolving treatment practices on coronary disease incidence rates, demographic and clinical profile, and the short-term outcomes of patients hospitalized with acute myocardial infarction have not been well characterized. The purpose of this study was to examine multidecade-long trends (1975-2005) in the incidence rates, demographic and clinical characteristics, treatment practices, and hospital outcomes of patients hospitalized with an initial acute myocardial infarction from a population-based perspective.
  
  
  RESULTS
  Residents of the Worcester, Mass, metropolitan area (median age, 37 years; 89% white) hospitalized with an initial acute myocardial infarction (n=8898) at all greater-Worcester medical centers during 15 annual periods between 1975 and 2005 comprised the sample of interest. The incidence rates of initial acute myocardial infarction were lower in 2005 (209 of 100,000 population) than in 1975 (277 of 100,000), although these trends varied inconsistently over time. Patients hospitalized during the most recent study years were significantly older (mean age, 64 years in 1975; 71 years in 2005), more likely to be women (38% in 1975; 48% in 2005), and have a greater prevalence of comorbidities. Hospitalized patients were increasingly more likely to receive effective cardiac medications and coronary interventional procedures for the period under investigation. Hospital survival rates improved significantly over time (81% survived in 1975; 91% survived in 2005), although varying trends were observed in the occurrence of clinically important complications.
  
  
  CONCLUSIONS
  The results of this community-wide investigation provide insight into the changing magnitude, characteristics, management practices, and outcomes of patients hospitalized with a first myocardial infarction.
authors.affiliation: Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Floyd
authors.forename: Jorge
authors.initials: J
authors.lastname: Yarzebski
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Spencer
authors.forename: Darleen
authors.initials: D
authors.lastname: Lessard
authors.forename: James E
authors.initials: JE
authors.lastname: Dalen
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Alpert
authors.forename: Joel M
authors.initials: JM
authors.lastname: Gore
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Goldberg
mesh_terms: D000046:Academic Medical Centers / Q000706:statistics & numerical data; D017677:Age Distribution; D000368:Aged; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D015897:Comorbidity; D001026:Coronary Artery Bypass / Q000706:statistics & numerical data; D005260:Female; D017052:Hospital Mortality / Q000639:trends*; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality* / Q000601:surgery; D011159:Population Surveillance; D015995:Prevalence; D017678:Sex Distribution; D015912:Thrombolytic Therapy / Q000706:statistics & numerical data
chemical_list: D002317:Cardiovascular Agents