Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis.
Finding a way to combine ultrasound and fluorescence optical imaging on an endorectal probe may improve early detection of prostate cancer. The ultrasound provides morphological information about the prostate, while the optical system detects and locates fluorophore-marked tumors. A tissue-mimicking phantom, which is representative of prostate tissues both on its optical (absorption mu(a) and diffusion mu(s) (')) and its ultrasound properties, has been made by our team. A transrectal probe adapted to fluorescence diffuse optical tomography measurements was also developed. Measurements were taken on the prostate phantom with this probe based on a pulsed laser and a time-resolved detection system. A reconstruction algorithm was then used to help locate and quantify fluorescent inclusions of different concentrations at fixed depths.
Boutet
Jerome
J
Département des Micro-Technologies pour la Biologie et la Santé, CEA-LETI-MINATEC French Atomic Energy Comission, 17 rue des Martyrs, Grenoble, F38054, France. jerome.boutet@cea.fr
Herve
Lionel
L
Debourdeau
Mathieu
M
Guyon
Laurent
L
Peltie
Philippe
P
Dinten
Jean-Marc
JM
Saroul
Laurent
L
Duboeuf
Francois
F
Vray
Didier
D
D004867:Equipment Design; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D019047:Phantoms, Imaging; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D012815:Signal Processing, Computer-Assisted; D013050:Spectrometry, Fluorescence / Q000295:instrumentation / Q000379:methods*; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods*