title: Immunogenicity of Haemophilus influenzae type b conjugate vaccines in Korean infants: a meta-analysis.
abstract: A meta-analysis was performed on the immunogenicity of Haemophilus influenzae type b (Hib) conjugate vaccines after 2 (2 and 4 months) and 3 doses (2, 4, and 6 months) in Korean infants. A database search of MEDLINE, KoreaMed, and Korean Medical Database was done. The primary outcome measure was the proportion of infants with anti-polyribosylribitol phosphate (PRP) concentrations > or =1.0 microg/mL. Eight studies including eleven trials were retrieved. One trial reported on the diphtheria toxoid conjugate vaccine (PRP-D) and 2 trials each on the mutant diphtheria toxin (PRP-CRM) and Neisseria meningitidis outer-membrane protein (PRP-OMP) conjugate vaccine. Heterogeneity in study designs between trials on PRP-CRM was noted and one trial reported on a monovalent and another on a combination PRP-OMP vaccine. Thus, a meta-analysis was conducted only on the tetanus toxoid conjugate vaccine (PRP-T). After a primary series of 2 doses and 3 doses, 80.6% (95% confidence interval [CI]; 76.0-85.1%) and 95.7% (95% CI; 94.0-98.0%) of infants achieved an antibody level > or =1.0 microg/mL, respectively. The immunogenic response to the PRP-T vaccine was acceptable after a primary series of 3 doses and also 2 doses. A reduced number of doses as a primary series could be carefully considered in Korean infants.
authors.affiliation: Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea.
authors.forename: Hyunju
authors.initials: H
authors.lastname: Lee
authors.forename: Seokyung
authors.initials: S
authors.lastname: Hahn
authors.forename: Hoan Jong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Kyung-Hyo
authors.initials: KH
authors.lastname: Kim
mesh_terms: D000906:Antibodies / Q000032:analysis; D016667:Bacterial Capsules / Q000276:immunology* / Q000378:metabolism; D018073:Haemophilus Vaccines / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007223:Infant; D056910:Republic of Korea; D013745:Tetanus Toxoid / Q000737:chemistry / Q000378:metabolism; D018074:Vaccines, Conjugate / Q000276:immunology / Q000378:metabolism
chemical_list: D000906:Antibodies; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D013745:Tetanus Toxoid; D018074:Vaccines, Conjugate