title: [Evaluation of morphine metabolism in presence of amantadine and dextromethorphan in human serum by high performance liquid chromatography coupled with mass spectrometry (LC/MS) method].
abstract: In the present study we assessed by LC/MS method the influence of amantadine and dextromethorphan on morphine metabolism in humans in order to explain clinically observed phenomenon of amplification of analgesic action of morphine by these drugs. Neither dextromethorphan nor amantadine influenced the rate of morphine degradation and concentration of morphine metabolites. Thus, our results suggest pharmacodynamical, not pharmacokinetic mechanism of interaction.
authors.affiliation: Katedra Farmakologii, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków, Poland. macieksuski@gmail.com
authors.forename: Maciej
authors.initials: M
authors.lastname: Suski
authors.forename: Beata
authors.initials: B
authors.lastname: Bujak-Gizycka
authors.forename: Józef
authors.initials: J
authors.lastname: Madej
authors.forename: Rafał
authors.initials: R
authors.lastname: Olszanecki
authors.forename: Ryszard
authors.initials: R
authors.lastname: Korbut
mesh_terms: D000547:Amantadine / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D003915:Dextromethorphan / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D013058:Mass Spectrometry; D009020:Morphine / Q000097:blood* / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy; D017288:Pain Threshold / Q000187:drug effects
chemical_list: D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D003915:Dextromethorphan; D009020:Morphine; D000547:Amantadine