title: [Switching to direct intrahepatic arterial infusion of 5-FU after a progression of liver metastases from colorectal carcinoma treated with systemic infusion of FOLFOX].
abstract: Direct intrahepatic arterial infusion of 5-FU produced a significantly higher response rate than systemic infusion of FOLFOX in the treatment of hepatic metastases from colorectal carcinoma. Fourteen patients switched over from systemic FOLFOX therapy to intrahepatic protracted 5-FU infusion after a progression of liver metastases treated with systemic therapy. Of the 14 patients whose tumors had initially failed to respond to systemic FOLFOX therapy, 12 (85%) had a partial response, and 13 (93%) had a reduction in their tumor marker (CEA, CA19-9, TPA) when the treatment was switched to intrahepatic 5-FU therapy. Traditional chemotherapy toxicity, such as myelosuppression, nausea, vomiting and neurotoxicity did not occur in the intrahepatic group. Three out of 14 patients survived more than a year, and the longest was 18 months. A better survival rate can be achieved with the use of hepatic artery infusion therapy.
authors.affiliation: Department of Clinical Oncology, Miura Hospital.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kikuoka
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miura
authors.forename: Ikuya
authors.initials: I
authors.lastname: Takeuchi
authors.forename: Takako
authors.initials: T
authors.lastname: Miura
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Akamatsu
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Ishida
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Ozawa
authors.forename: Masamichi
authors.initials: M
authors.lastname: Moriguchi
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000473:pathology*; D005472:Fluorouracil / Q000008:administration & dosage*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary*; D009944:Organoplatinum Compounds / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil