title: Inhibitory effect of curcumin on IMP dehydrogenase, the target for anticancer and antiviral chemotherapy agents.
abstract: Inosine monophosphate dehydrogenase (IMPDH), a rate-limiting enzyme in the de novo synthesis of guanine nucleotides, is a therapeutic target for anticancer and antiviral agents. Among the 15 different polyphenols examined, curcumin was found to have an inhibitory effect on the IMPDH activity in both a competitive and uncompetitive manner and to suppress the cellular GTP level in HT-29 colon carcinoma cells.
authors.affiliation: Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Japan.
authors.forename: Issei
authors.initials: I
authors.lastname: Dairaku
authors.forename: Yunkyung
authors.initials: Y
authors.lastname: Han
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Yanaka
authors.forename: Norihisa
authors.initials: N
authors.lastname: Kato
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism*; D000998:Antiviral Agents / Q000378:metabolism*; D003474:Curcumin / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D051379:Mice; D010636:Phenols / Q000494:pharmacology; D059808:Polyphenols
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D007168:IMP Dehydrogenase; D003474:Curcumin