title: Pars plana vitrectomy in the management of paediatric uveitis: the Massachusetts Eye Research and Surgery Institution experience.
abstract: OBJECTIVE
  To assess the effectiveness and safety of pars plana vitrectomy (PPV) in the management of chronic paediatric uveitis.
  
  
  METHODS
  We reviewed records of patients 16 years old or younger who underwent PPV due to persistent uveitis. Data including inflammatory status, ocular findings, visual acuity, dosage and duration of various medical therapies, surgical techniques and complications were collected.
  
  
  RESULTS
  Twenty-eight eyes of 20 patients were included in the study. The diagnoses of uveitis included pars planitis in 15 eyes (54%), idiopathic panuveitis in 8 eyes (29%), and juvenile idiopathic arthritis-associated iridocyclitis in five eyes (18%). Six eyes presented with associated retinal vasculitis. The mean age at the time of PPV was 11.2 years. The mean follow-up after surgery was 13.5 months. All 28 eyes had active uveitis with or without medical therapy at the time of PPV. At last follow-up, uveitis control was achieved with or without adjuvant medical therapy in 27 eyes (96%). These included five of the six eyes with persistent retinal vasculitis. Two eyes that had 20-G PPV developed intra-operative retinal tears. Four eyes with pre-operative clear lenses developed cataract within the first 6 months after PPV.
  
  
  CONCLUSIONS
  PPV is effective and safe in the management of chronic paediatric uveitis and its complications. It was able to reduce the amount of systemic medications required to control inflammation in this study. Patients with uveitis complicated by retinal vasculitis, however, are more likely to require long-term medical therapy to achieve inflammatory control.
authors.affiliation: Massachusetts Eye Research and Surgery Institution, Cambridge, MA 02142, USA. gpgiuliari@gmail.com
authors.forename: G P
authors.initials: GP
authors.lastname: Giuliari
authors.forename: P Y
authors.initials: PY
authors.lastname: Chang
authors.forename: P
authors.initials: P
authors.lastname: Thakuria
authors.forename: D M
authors.initials: DM
authors.lastname: Hinkle
authors.forename: C S
authors.initials: CS
authors.lastname: Foster
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D031300:Retinal Vasculitis / Q000601:surgery; D014605:Uveitis / Q000503:physiopathology / Q000601:surgery*; D014792:Visual Acuity; D014821:Vitrectomy / Q000379:methods*