title: [Metformin-associated hepatotoxicity].
abstract: Metformin is an oral biguanide widely used in the management of patients with type 2 diabetes. It produces non-specific gastrointestinal symptoms in 10-30% of the patients. Lactic acidosis is the most serious side effect, so it must not be administered to patients with renal, liver, or heart insufficiency. Only a few cases of hepatotoxicity due to this drug have been documented. We report the case of a patient with type 2 diabetes mellitus and recent use of metformin who developed serious liver injury, followed by a favorable evolution.
authors.affiliation: Servicio de Medicina Interna, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España. susana.olivera@yahoo.es
authors.forename: S
authors.initials: S
authors.lastname: Olivera-González
authors.forename: B
authors.initials: B
authors.lastname: de Escalante-Yangüela
authors.forename: C
authors.initials: C
authors.lastname: Velilla-Soriano
authors.forename: B
authors.initials: B
authors.lastname: Amores-Arriaga
authors.forename: P
authors.initials: P
authors.lastname: Martín-Fortea
authors.forename: M E
authors.initials: ME
authors.lastname: Navarro-Aguilar
mesh_terms: D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008687:Metformin / Q000009:adverse effects*
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin