title: [Hepatitis and coagulopathy secondary to neonatal enteroviral infection].
abstract: Enteroviruses cause a wide spectrum of clinical manifestations in neonates, from asymptomatic infection to severe and fulminant, sometimes fatal disease. A septic disease is the clinical manifestation of one fourth of the cases in neonates, with multiorganic affection. Hepatitis and coagulopathy are related to bad prognosis, generally associated to catastrophic hemorrhages. In those cases, an aggressive support therapy and correct administration of platelet and clotting factor replacement is necessary. The liver, in survivors, frequently has sufficient regenerative capacity to allow normalization of hepatic function and adequate growth of the child. We present the case of a newborn who developed hepatitis and coagulopathy secondary to an enteroviral infection, with total recovery and absence of hemorrhagic complication. Her mother had a febrile syndrome 24 hours ante partum.
authors.affiliation: Unidad de Cuidados Intensivos Neonatal y Pediátrica, Hospital Universitario Madrid-Montepríncipe, Madrid. pdacoca@hotmail.com
authors.forename: Ana C
authors.initials: AC
authors.lastname: Pérez
authors.forename: Virginia
authors.initials: V
authors.lastname: Soler Vigil
authors.forename: Silvina
authors.initials: S
authors.lastname: Giannivelli
authors.forename: Alejandra
authors.initials: A
authors.lastname: López Guinea
authors.forename: Rosa
authors.initials: R
authors.lastname: Pérez-Piaya Moreno
mesh_terms: D001778:Blood Coagulation Disorders / Q000209:etiology*; D004769:Enterovirus Infections / Q000150:complications*; D005260:Female; D006505:Hepatitis / Q000209:etiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn