Lanostane triterpenes from the fruiting bodies of Ganoderma lucidum and their inhibitory effects on adipocyte differentiation in 3T3-L1 Cells.
Four new lanostane triterpenes, butyl ganoderate A (1), butyl ganoderate B (2), butyl lucidenate N (3), and butyl lucidenate A (4), were isolated from the fruiting bodies of Ganoderma lucidum together with 14 known compounds (5-18). The structures of the new triterpenes were established by extensive spectroscopic studies and chemical evidence. In addition, the inhibitory effect of isolated compounds on adipocyte differentiation in 3T3-L1 cells was examined.
Lee
IkSoo
I
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
Seo
JungJu
J
Kim
JinPyo
J
Kim
HongJin
H
Youn
UiJung
U
Lee
Joonseok
J
Jung
HyunJu
H
Na
MinKyun
M
Hattori
Masao
M
Min
ByungSun
B
Bae
KiHwan
K
D041721:3T3-L1 Cells; D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D007564:Japan; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D020940:Reishi / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D014315:Triterpenes; D007810:Lanosterol