Development and application of a solution-phase automated synthesizer, 'ChemKonzert'.
In this paper we describe the development of a fully-automated solution-phase synthesizer, 'ChemKonzert' that can be used to prepare a wide variety of organic compounds. The automated synthesizer is ingeniously designed to perform most of the chemical reactions currently used by synthetic organic chemists and utilizes a centrifugal separator to efficiently achieve liquid-liquid extraction. The design of the hardware and software will be described in this paper, and several examples of organic reactions will also be presented as applications of the apparatus.
Machida
Kazuhiro
K
Development Department, ChemGenesis Incorporated, Tokyo, Japan. kmachida@chemgenesis.com
Hirose
Yoichiro
Y
Fuse
Shinichiro
S
Sugawara
Tohru
T
Takahashi
Takashi
T
D001331:Automation; D002498:Centrifugation / Q000295:instrumentation* / Q000379:methods; D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D012984:Software