Acceptability of a non-woven device for vaginal drug delivery of microbicides or other active agents.
Vaginal microbicides could reduce incidence of HIV. However, the current method of delivering gel formulations (standard applicator) can result in acceptability concerns/issues. This study evaluated the concept of using a non-woven textile material (modified tampon) for vaginal drug delivery. The study was nested within a Phase I randomized safety trial of lime juice concentrations used intra-vaginally. Of 47 women completing the safety trial, 16 were interviewed about their experiences. Overall, women found the concept of non-woven materials for vaginal drug delivery acceptable for use in delivering yeast medications (13 of 16) and STI/HIV preventives (10 of 16).
Joanis
Carol L
CL
Behavioral and Biomedical Research Department, Family Health International, P.O. Box 13950, Research Triangle Park, NC 27709, USA. cjoanis@fhi.org
Hart
Catherine W
CW
D000282:Administration, Intravaginal; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D032082:Citrus aurantiifolia; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000706:statistics & numerical data; D005260:Female; D015658:HIV Infections / Q000517:prevention & control*; D015497:HIV-1; D006801:Humans; D052576:Menstrual Hygiene Products; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D012749:Sexually Transmitted Diseases / Q000517:prevention & control*; D014622:Vaginal Creams, Foams, and Jellies / Q000008:administration & dosage; D055815:Young Adult
D000890:Anti-Infective Agents; D014622:Vaginal Creams, Foams, and Jellies