Role of dentate gyrus alterations in mesial temporal sclerosis.
Drug-resistant chronic temporal lobe epilepsy is the most common type of epilepsy that undergoes surgical treatment. To verify if dentate gyrus alterations may play a role in patients with mesial temporal sclerosis (MTS), 14 patients, submitted to epilepsy surgery, were selected. Only cases with MTS alone were included. Granule cell dispersion (GCD) was observed in 7 cases (50%). A statistically significant correlation between GCD and the mean number of seizures/month was evidenced. The percentage of patients who did not achieve seizure relief (i.e. they were not in Engel class 1A) was 57.14% in patients without GCD, whereas that percentage dropped to 14.29% in patients with GCD. The association between a more favorable postsurgical epileptogenic outcome and granule cell pathology in patients with MTS has been observed, thus suggesting that dentate gyrus alterations may play a role in drug-resistant TLE.
Marucci
G
G
Section of Pathology, Department of Hematology and Oncology of the University of Bologna, Bologna, Italy. gianluca.marucci@ausl.bologna.it
Rubboli
G
G
Giulioni
M
M
D000328:Adult; D034961:Antigens, Nuclear / Q000378:metabolism; D001927:Brain Diseases / Q000378:metabolism / Q000473:pathology*; D018891:Dentate Gyrus / Q000378:metabolism / Q000473:pathology*; D004827:Epilepsy / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D005260:Female; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D012598:Sclerosis / Q000378:metabolism / Q000473:pathology; D012640:Seizures / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000378:metabolism / Q000473:pathology*; D016896:Treatment Outcome; D055815:Young Adult
D034961:Antigens, Nuclear; D009419:Nerve Tissue Proteins; C506808:neuronal nuclear antigen NeuN, human