title: [Effects of melatonin on nociception processes in experimentally model of neurophatic pain].
abstract: Melatonin (MT) plays an important role in the regulation of physiological and neuroendocrine functions, such as control of circadian rhythms and synchronization of seasonal reproductive rhythms in mammals. Melatonin shows its antinocieeptive effects in a dose - dependent manner. Melatonin is influencing the mechanical allodynia but not thermal hyperalogia. Antinociceptive effects of melatonin are having the significant connection with the MT2 receptor stimulation and activation of the opioid system.
authors.affiliation: Katedra Patofizjologii, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków, Poland. danski@mp.pl
authors.forename: Daniel
authors.initials: D
authors.lastname: Zurowski
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Nowak
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Ciesielczyk
authors.forename: Anna
authors.initials: A
authors.lastname: Machowska
authors.forename: Piotr J
authors.initials: PJ
authors.lastname: Thor
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D008550:Melatonin / Q000008:administration & dosage* / Q000378:metabolism*; D009619:Nociceptors / Q000187:drug effects*; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D044123:Receptor, Melatonin, MT2 / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism; D012584:Sciatic Nerve / Q000293:injuries; D020426:Sciatic Neuropathy / Q000188:drug therapy*
chemical_list: D044123:Receptor, Melatonin, MT2; D011957:Receptors, Opioid; D008550:Melatonin