title: The effects of applying adhesion prevention gel on the range of motion and pain after TKA.
abstract: A mixed solution of sodium hyaluronate and sodium carboxymethylcellulose (HA/CMC) has been shown to be effective for decreasing postoperative adhesions in various kinds of surgeries. We evaluated the clinical efficacy and safety of HA/CMC gel on the early postoperative range of motion and pain relief after total knee arthroplasty (TKA). Thirty one patients who underwent bilateral TKA as a single-stage procedure for primary osteoarthritis were included in the study. At the completion of surgery, among both knees, the HA/CMC gel was applied to one knee (the HA/CMC group) and HA/CMC gel was not applied to the other knee (the control group). The primary outcome measure was the early assessment of range of motion and the secondary outcome measures were the VAS pain scores and the number of complications in each group. Periarticular application of HA/CMC gel was safe without causing any wound problems or infection. However, local application of HA/CMC gel neither increased the range of motion nor reduced the pain during the early postoperative period of TKA.
authors.affiliation: Department of Orthopedic Surgery, Uijongbu St. Mary's Hospital, The Catholic University of Korea, 65-1 Kumoh-Dong, Uijongbu-Si, Kyonggi-Do, 480-130, Republic of Korea.
authors.forename: Chae-Gwan
authors.initials: CG
authors.lastname: Kong
authors.forename: Yong
authors.initials: Y
authors.lastname: In
authors.forename: Hyun-Min
authors.initials: HM
authors.lastname: Cho
authors.forename: Kyung-Hwan
authors.initials: KH
authors.lastname: Suhl
mesh_terms: D000287:Administration, Topical; D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000534:rehabilitation*; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005782:Gels; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D007719:Knee Joint / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000503:physiopathology / Q000517:prevention & control*; D011446:Prospective Studies; D016059:Range of Motion, Articular / Q000187:drug effects / Q000502:physiology; D000267:Tissue Adhesions / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D005782:Gels; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium