Discovery of anticancer agents of diverse natural origin.
A collaborative multidisciplinary research project is described in which new natural product anticancer drug leads are obtained from a diverse group of organisms, constituted by tropical plants, aquatic cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which crude extracts of these acquisitions are tested. Progress made in the isolation of lead bioactive secondary metabolites from three tropical plants is discussed.
Kinghorn
A Douglas
AD
College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Carcache de Blanco
Esperanza J
EJ
Chai
Hee-Byung
HB
Orjala
Jimmy
J
Farnsworth
Norman R
NR
Soejarto
D Doel
DD
Oberlies
Nicholas H
NH
Wani
Mansukh C
MC
Kroll
David J
DJ
Pearce
Cedric J
CJ
Swanson
Steven M
SM
Kramer
Robert A
RA
Rose
William C
WC
Fairchild
Craig R
CR
Vite
Gregory D
GD
Emanuel
Stuart
S
Jarjoura
David
D
Cope
Frederick O
FO