title: Ingenuity pathway analysis of clozapine-induced obesity.
abstract: BACKGROUND
  Lipid accretion is one of the major side effects of clozapine pharmacotherapy of schizophrenia that made clozapine into an interesting obesity drug model.
  
  
  METHODS
  Ingenuity Pathway Analysis (IPA) engine was used for core analysis and building the networks of weight regulation.
  
  
  RESULTS
  The examination of molecules that were selected into 'clozapine neighborhood' identified them as multifunctional signals that appear to orchestrate vascular and tissue functions plausibly implicated in adiposity side effect.
  
  
  CONCLUSIONS
  It is hypothesized that clozapine unmasks the functional and morphological phenotype of microvascular deficit that facilitates shunting nutrients from utilization toward storage.
authors.affiliation: Howard University Graduate School, Washington, DC, USA. myslobom@mail.nih.gov
authors.forename: Michael
authors.initials: M
authors.lastname: Myslobodsky
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000502:physiology; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003024:Clozapine / Q000009:adverse effects*; D006801:Humans; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D008954:Models, Biological; D018377:Neurotransmitter Agents / Q000502:physiology; D009765:Obesity / Q000139:chemically induced*; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D018377:Neurotransmitter Agents; D003024:Clozapine