title: [A case of advanced esophageal cancer with para-aortic lymph node metastasis with complete response (CR) to combination chemotherapy including nedaplatin].
abstract: The patient was a 55-year-old male, who was diagnosed to have a middle thoracic esophageal squamous cell carcinoma with para-aortic lymph node metastasis. The clinical stage diagnosis was T3N4M1, stage IVb, non-resectable esophageal SCC. Systemic chemotherapy with low-dose nedaplatin/5-FU treatment was started as the initial treatment. After three courses, para-aortic lymph node metastasis was not found by CT scan, and we added radiation therapy. After radiation therapy by 45 Gy, primary lesion and mediasternal lymph node metastasis were not shown by endoscopy and CT scan. We detected an increase of tumor marker after the observation for six months without any treatment, and then we started docetaxel/nedaplatin treatment as secondary chemotherapy. After ten courses, the tumor marker was decreased, and the patient is still in a stable disease state. We concluded that FGP therapy and DGP therapy were a very effective treatment for advanced esophageal SCC.
authors.affiliation: Department of Surgical Oncology, Osaka City University Graduate School of Medicine.
authors.forename: Satoru
authors.initials: S
authors.lastname: Noda
authors.forename: Naoshi
authors.initials: N
authors.lastname: Kubo
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Kazuya
authors.initials: K
authors.lastname: Muguruma
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yashiro
authors.forename: Nobuya
authors.initials: N
authors.lastname: Yamada
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Maeda
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Sawada
authors.forename: Masaichi
authors.initials: M
authors.lastname: Ohira
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Kosei
authors.initials: K
authors.lastname: Hirakawa
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C053989:nedaplatin