title: Prevalence and perinatal outcome of dichorionic and monochorionic twins with nuchal translucency above the 99(th) percentile and normal karyotype.
abstract: OBJECTIVE
  To evaluate the prevalence of and perinatal outcome associated with increased nuchal translucency thickness (NT) > 99(th) percentile in dichorionic and monochorionic twins with normal karyotype.
  
  
  METHODS
  Two hundred and six consecutive twin pregnancies (166 dichorionic and 40 monochorionic) underwent an NT scan during a 4-year period. In those with NT > 99(th) percentile and normal karyotype, we performed first- and second-trimester anomaly scans, fetal echocardiography at 14-16 and 20-22 weeks, maternal serology and, in monochorionic pregnancies, serial ultrasound examinations every other week. Perinatal outcome was recorded.
  
  
  RESULTS
  There were 10 (4.95%) pregnancies in which one of the fetuses had NT > 99(th) percentile and normal karyotype, including five fetuses (1.5%) in dichorionic and five (6.25%) in monochorionic pregnancies. During the same period the prevalence of NT > 99(th) percentile and normal karyotype in singleton pregnancies studied in our center was 2.6%. Among the 10 twins affected, six (60%) were diagnosed with structural abnormalities (three dichorionic and three monochorionic), and two intrauterine fetal demises occurred (one dichorionic and one monochorionic). Thus, the perinatal outcome was normal in only two of the pregnancies, one dichorionic and one monochorionic.
  
  
  CONCLUSIONS
  The prevalence of NT > 99(th) percentile in dichorionic twins with a normal karyotype is similar to that in singletons. In monochorionic twins we confirmed previous studies reporting an increased prevalence compared with singletons. NT > 99(th) percentile with a normal karyotype in twins was associated with a high rate of fetal abnormalities and/or fetal demise (overall 80%) irrespective of chorionicity.
authors.affiliation: Department of Maternal-Fetal Medicine, Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain. agonce@clinic.ub.es
authors.forename: A
authors.initials: A
authors.lastname: Goncé
authors.forename: A
authors.initials: A
authors.lastname: Borrell
authors.forename: E
authors.initials: E
authors.lastname: Meler
authors.forename: M
authors.initials: M
authors.lastname: Arigita
authors.forename: J M
authors.initials: JM
authors.lastname: Martínez
authors.forename: F
authors.initials: F
authors.lastname: Botet
authors.forename: A
authors.initials: A
authors.lastname: Sánchez
authors.forename: E
authors.initials: E
authors.lastname: Gratacós
mesh_terms: D000328:Adult; D004200:Diseases in Twins / Q000000981:diagnostic imaging* / Q000196:embryology / Q000235:genetics; D005260:Female; D005313:Fetal Death / Q000000981:diagnostic imaging* / Q000235:genetics; D005865:Gestational Age; D006801:Humans; D048208:Nuchal Translucency Measurement / Q000379:methods* / Q000706:statistics & numerical data; D011247:Pregnancy; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D014429:Twins, Dizygotic / Q000235:genetics*; D014430:Twins, Monozygotic / Q000235:genetics*