[A case of successful control of recurrent duodenal carcinoma receiving paclitaxel].
We have experienced a case of successful control of recurrent duodenal carcinoma receiving paclitaxel chemotherapy. A 61-year-old woman with epigastralgia was diagnosed with pyloric gastric carcinoma upon upper gastrointestinal endoscopy and biopsy. Distal gastrectomy with D2 dissection was performed. However, at the resected organ, the lesion was on the duodenum. So, we additionally resected the anal edge. And 13a, 13b, 12a, p lymph nodes were dissected for duodenal carcinoma. Later, the CEA level was increased, and abdominal CT scan showed swelling of paraaortic lymph nodes. Recurrence of the duodenal carcinoma was diagnosed in February 2007, and S-1 administration was begun. But, we dosed down with S-1 due to severe diarrhea. In spite of combined S-1 and CPT-11 chemotherapy, the CEA level increased, and lymph nodes were getting larger. She then underwent the paclitaxel chemotherapy during the 5 months without severe side effects. The CEA level decreased significantly and metastatic lymph nodes were reduced observed by CT scan. Paclitaxel chemotherapy is effective for duodenal cancer.
Taniguchi
Masaaki
M
Department of Surgery, Hyogo Prefectural Nishinomiya Hospital.
Ookubo
Keita
K
Ootsuka
Masahisa
M
Akitake
Hironori
H
Maekawa
Takayo
T
Yoshioka
Shinichi
S
Hama
Naoki
N
Kashiwazaki
Masaki
M
Tsujie
Masaki
M
Konishi
Muneharu
M
Ebisui
Chikara
C
Fujimoto
Takayoshi
T
D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D002334:Carnitine O-Palmitoyltransferase / Q000627:therapeutic use; D004338:Drug Combinations; D004379:Duodenal Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D010094:Oxonic Acid / Q000627:therapeutic use; D017239:Paclitaxel / Q000627:therapeutic use*; D005641:Tegafur / Q000627:therapeutic use
D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002334:Carnitine O-Palmitoyltransferase; D017239:Paclitaxel