title: Cell-targeting and cell-penetrating peptides for delivery of therapeutic and imaging agents.
abstract: This review will discuss the basic concepts concerning the use of cell-targeting peptides (CTPs) and cell-penetrating peptides (CPPs) in the context of nanocarrier technology. It deals with the discovery and subsequent evolution of CTPs and CPPs, issues concerning their interactions with cells and their biodistribution in vivo, and their potential advantages and disadvantages as delivery agents. The article also briefly discusses several specific examples of the use of CTPs or CPPs to assist in the delivery of nanoparticles, liposomes, and other nanocarriers.
authors.affiliation: Department of Pharmacology, University of North Carolina, Chapel Hill, USA. arjay@med.unc.edu
authors.forename: Rudolph L
authors.initials: RL
authors.lastname: Juliano
authors.forename: Rowshon
authors.initials: R
authors.lastname: Alam
authors.forename: Vidula
authors.initials: V
authors.lastname: Dixit
authors.forename: Hyun Min
authors.initials: HM
authors.lastname: Kang
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D050997:Nanomedicine / Q000639:trends; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010455:Peptides / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D010455:Peptides