title: Therapy failure following selection of enfuvirtide-resistant HIV-1 in cerebrospinal fluid.
abstract: We report the selection of enfuvirtide-resistant human immunodeficiency virus type 1 in cerebrospinal fluid, resulting in subsequent loss of viral suppression in the plasma. This case report emphasizes the potential danger of low-level penetration of entry inhibitors into the central nervous system.
authors.affiliation: Department of Virology, University Medical Center Utrecht, G04.614 Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
authors.forename: S F L
authors.initials: SF
authors.lastname: van Lelyveld
authors.forename: M
authors.initials: M
authors.lastname: Nijhuis
authors.forename: F
authors.initials: F
authors.lastname: Baatz
authors.forename: I
authors.initials: I
authors.lastname: Wilting
authors.forename: W M
authors.initials: WM
authors.lastname: van den Bergh
authors.forename: M
authors.initials: M
authors.lastname: Kurowski
authors.forename: D
authors.initials: D
authors.lastname: de Jong
authors.forename: A I M
authors.initials: AI
authors.lastname: Hoepelman
authors.forename: A M J
authors.initials: AM
authors.lastname: Wensing
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000821:virology*; D024882:Drug Resistance, Viral; D000077560:Enfuvirtide; D015700:HIV Envelope Protein gp41 / Q000494:pharmacology* / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000494:pharmacology* / Q000627:therapeutic use; D012641:Selection, Genetic; D017211:Treatment Failure
chemical_list: D019380:Anti-HIV Agents; D015700:HIV Envelope Protein gp41; D010446:Peptide Fragments; D000077560:Enfuvirtide