Relationship between CX3CR1 genetic polymorphism and carotid atherosclerosis.
To investigate the possible association between V249I and T280M polymorphisms and carotid atherosclerosis (CAS) in a Han population in northern China we studied 328 patients with increased carotid artery intima-media thickness (C-IMT) and 292 healthy controls with normal C-IMT. T280M and V249I polymorphic genotypes of CX3CR1 were determined by polymerase chain reaction restriction fragment length polymorphism. Results showed that the M280 allele frequency in CAS group was significantly lower than that in the controls. Logistic regression analysis revealed that the decreased frequency of the M280 allele was an independent risk factor for CAS.
Zhao
Renliang
R
Department of Neurology, Affiliated Hospital, Medical College, Qingdao University, No. 38 Dengzhou Road, Qingdao, Shandong, China.
Wang
Yongjun
Y
Shen
Ruowu
R
Sun
Yong
Y
D000368:Aged; D002340:Carotid Artery Diseases / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D054367:Receptors, CXCR3 / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors
C515187:CXCR3 protein, human; D054367:Receptors, CXCR3