Clindamycin-resistant group B Streptococcus and failure of intrapartum prophylaxis to prevent early-onset disease.
Guidelines recommend intrapartum antibiotic prophylaxis (IAP) for parturient women who have a screen positive for group B Streptococcus (GBS). Clindamycin should be used for IAP only if the maternal GBS isolate is susceptible. We report a case of clindamycin-resistant GBS disease in a newborn infant whose mother received clindamycin IAP, and we review clindamycin susceptibility testing.
Blaschke
Anne J
AJ
Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA. anne.blaschke@hsc.utah.edu
Pulver
Laurie S
LS
Korgenski
E Kent
EK
Savitz
Lucy A
LA
Daly
Judy A
JA
Byington
Carrie L
CL
D019072:Antibiotic Prophylaxis; D002981:Clindamycin / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008297:Male; D008826:Microbial Sensitivity Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D013290:Streptococcal Infections / Q000188:drug therapy / Q000517:prevention & control*; D013292:Streptococcus agalactiae / Q000187:drug effects
D002981:Clindamycin