title: Prostate cancer risk allele specific for African descent associates with pathologic stage at prostatectomy.
abstract: OBJECTIVE
  A region on chromosome 8q24 was recently identified as a novel prostate cancer risk locus. Inherited variation in this region is associated with prostate cancer risk in the general population (21-58%), and specific alleles show a strong association in African-American men. This study was designed to evaluate associations between 8q24 risk alleles and clinical variables, such as pathologic stage, age at diagnosis, and recurrence, in a case series of African-American men.
  
  
  METHODS
  Peripheral blood DNA samples from 114 African-American men with prostate cancer, including 106 who had undergone radical prostatectomy, were genotyped for six single-nucleotide polymorphisms on three 8q24 regions. The presence of these single-nucleotide polymorphisms was compared with clinicopathologic and follow-up data after radical prostatectomy.
  
  
  RESULTS
  The mean age of diagnosis and follow-up time were 57.4 (+/-8.9) years and 49.1 (+/-31.6) months, respectively. Patients carrying the Broad11934905 A risk allele, which is specific for African ancestry, were more likely to have a higher pathologic stage (pT(3-4)) than individuals with the wild type (odds ratio, 4.48; 95% confidence interval, 1.42-14.14; P = 0.011). A trend toward increased frequency of and shorter time to biochemical recurrence was noted in patients with this risk allele on Kaplan-Meier unadjusted survival analysis (P = 0.076).
  
  
  CONCLUSIONS
  The Broad11934905 polymorphism at 8q24, which is only found in people of African ancestry, is associated with an increase in non-organ-confined prostate cancer at prostatectomy. In addition, for those with this risk allele, there is a trend toward early biochemical recurrence that requires validation in larger studies.
authors.affiliation: Urology Service, Department of Surgery, Walter Reed Army Medical Center, Washington, District of Columbia, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Whitman
authors.forename: Mark
authors.initials: M
authors.lastname: Pomerantz
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Chen
authors.forename: Michael M
authors.initials: MM
authors.lastname: Chamberlin
authors.forename: Bungo
authors.initials: B
authors.lastname: Furusato
authors.forename: Chunling
authors.initials: C
authors.lastname: Gao
authors.forename: Amina
authors.initials: A
authors.lastname: Ali
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Ravindranath
authors.forename: Albert
authors.initials: A
authors.lastname: Dobi
authors.forename: Isabell A
authors.initials: IA
authors.lastname: Sesterhenn
authors.forename: Isabell A
authors.initials: IA
authors.lastname: Sestrehenn
authors.forename: David G
authors.initials: DG
authors.lastname: McLeod
authors.forename: Shiv
authors.initials: S
authors.lastname: Srivastava
authors.forename: Matthew
authors.initials: M
authors.lastname: Freedman
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Petrovics
mesh_terms: D001741:Black or African American / Q000235:genetics*; D000483:Alleles; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D012307:Risk Factors