Vitamin A supplementation for different periods alters oxidative parameters in lungs of rats.
Lungs require an adequate supply of vitamin A (retinol) for normal embryonic development, postnatal maturation, and maintenance and repair during adult life. However, recent intervention studies revealed that supplementation with retinoids resulted in higher incidence of lung cancer, although the mechanisms underlying this effect are still unknown. Here, we studied the effect of vitamin A supplementation on oxidative stress parameters in lungs of Wistar rats. Vitamin A supplementation at either therapeutic (1,000 and 2,500 IU/kg) or excessive (4,500 and 9,000 IU/kg) doses for 3, 7, or 28 days induced lipid peroxidation, protein carbonylation, and oxidation of protein thiol groups, as well as change in catalase and superoxide dismutase activity. Together, these results suggest that vitamin A supplementation causes significant changes in redox balance, which are frequently associated with severe lung dysfunction.
Pasquali
Matheus Augusto de Bittencourt
MA
Centro de Estudos em Estresse Oxidativo, Universidade Federal do Rio Grande do Sul, Departamento de Bioquímica, Porte Alegre, Rio Grande do Sul, Brazil.
Gelain
Daniel Pens
DP
de Oliveira
Marcos Roberto
MR
Behr
Guilherme Antônio
GA
da Motta
Leonardo Lisbôa
LL
da Rocha
Ricardo Fagundes
RF
Klamt
Fábio
F
Moreira
José Cláudio Fonseca
JC
D000818:Animals; D019587:Dietary Supplements / Q000009:adverse effects*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014801:Vitamin A / Q000008:administration & dosage / Q000009:adverse effects*
D014801:Vitamin A