title: Successful intra-arterial chemotherapy for extramammary Paget's disease of the axilla in a patient with Parkinson's disease.
abstract: Extramammary Paget's disease (EMPD) is a rare intraepithelial neoplasm occurring less frequently in men and even more rarely in the axilla. A 59-year-old man with severe Parkinson's disease presented with axillary EMPD. The neurological comorbidity made treatment of the EMPD problematical and prompted us to propose locoregional intra-arterial chemotherapy in single short sessions. Two innovative chemotherapeutic macrocomplexes were used: doxorubicin incorporated in large liposomes and the taxane paclitaxel incorporated in albumin nanoparticles. A therapeutic response was seen right from the first treatment and was macroscopically close to complete after four cycles. Five months after the end of treatment the patient had minimal visible disease and had enjoyed a distinct improvement in quality of life, with no noteworthy complications related to the intra-arterial chemotherapy with percutaneous transfemoral catheterization.
authors.affiliation: Department of Radiology and Diagnostic Imaging 2, Istituto Nazionale per lo studio e cura dei Tumori, Via Venezian 1, 20133 Milan, Italy. bruno.damascelli@istitutotumori.mi.it
authors.forename: Bruno
authors.initials: B
authors.lastname: Damascelli
authors.forename: Vladimira
authors.initials: V
authors.lastname: Ticha
mesh_terms: D000792:Angiography; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001365:Axilla / Q000098:blood supply / Q000473:pathology; D001706:Biopsy; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D053758:Nanoparticles; D017239:Paclitaxel / Q000008:administration & dosage; D010145:Paget Disease, Extramammary / Q000098:blood supply / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D010300:Parkinson Disease / Q000150:complications*; D012867:Skin / Q000473:pathology
chemical_list: D004317:Doxorubicin; D017239:Paclitaxel