title: Subcellular targeting strategies for drug design and delivery.
abstract: Many drug targets are localized to particular subcellular compartments, yet current drug design strategies are focused on bioavailability and tissue targeting and rarely address drug delivery to specific intracellular compartments. Insights into how the cell traffics its constituents to these different cellular locations could improve drug design. In this Review, we explore the fundamentals of membrane trafficking and subcellular organization, as well as strategies used by pathogens to appropriate these mechanisms and the implications for drug design and delivery.
authors.affiliation: Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, Zurich, Switzerland. rajendran@bli.uzh.ch
authors.forename: Lawrence
authors.initials: L
authors.lastname: Rajendran
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Knölker
authors.forename: Kai
authors.initials: K
authors.lastname: Simons
mesh_terms: D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D016503:Drug Delivery Systems; D015195:Drug Design; D004345:Drug Industry / Q000379:methods; D006801:Humans; D013347:Subcellular Fractions / Q000378:metabolism