[A case of acute cholestatic hepatitis induced by Corydalis speciosa Max].
Herbs are widely used as treatments for various symptoms. However, several herbs have been reported to be inducers of liver injury. We report herein a case of hepatotoxicity induced by Corydalis speciosa Max. A 37-year-old male complained of jaundice and mild abdominal discomfort. A thorough history was taken, and laboratory investigation, diagnostic imaging studies, and percutaneous liver biopsy sampling were conducted to determine the cause of liver injury. An accurate cause was not revealed. We administered supportive management for acute cholestatic hepatitis of unknown origin, after which his symptoms disappeared and serum aminotransferase levels decreased gradually to near normal levels. However, at 2 months after discharge, the symptoms and the elevation of aminotransferase levels recurred. At that time he told us that he had repeatedly but unintentionally eaten a herb called "Hwang-geun cho"(Corydalis speciosa Max.). Thus, we diagnosed his case as herbal hepatotoxicity.
Kang
Hyun Seok
HS
Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Choi
Hyuk Soon
HS
Yun
Tae Jung
TJ
Lee
Kwang Gyun
KG
Seo
Yeon Seok
YS
Yeon
Jong Eun
JE
Byun
Kwan Soo
KS
Um
Soon Ho
SH
Kim
Chang Duck
CD
Ryu
Ho Sang
HS
D000208:Acute Disease; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000473:pathology; D031311:Corydalis / Q000737:chemistry*; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000633:toxicity*; D014057:Tomography, X-Ray Computed
D010936:Plant Extracts; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin