Phosphatase of regenerating liver-3: a novel and promising marker in human endometriosis.
OBJECTIVE
To investigate the expression of phosphatase of regenerating liver-3 (PRL-3) in ectopic, eutopic, and normal endometria and explore its relationship with endometriosis.


METHODS
A clinical retrospective and molecular study.


METHODS
Department of obstetrics, gynecology, and reproductive medicine.


METHODS
One hundred and five women with histopathologically confirmed endometriosis, and 50 women with histopathologically assessed normal endometria.


METHODS
Immunohistochemical staining and Western blot analysis.


METHODS
Expression of PRL-3 protein.


RESULTS
As shown by the immunohistochemical analysis, PRL-3 was mainly located in the cytoplasm and membrane. The cells that tested positive for PRL-3 were detected in endometriotic tissues that did not occur in eutopic and normal endometria. Statistical analysis indicated that the expression of PRL-3 was closely associated with the clinical stages and recurrence of endometriosis.


CONCLUSIONS
Expression of PRL-3 is related to the clinical stages and recurrence of endometriosis, which provides use with a novel marker and promising target in the treatment of human endometriosis.
Ruan
Fei
F
Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Lin
Jun
J
Wu
Rui-Jin
RJ
Xu
Kai-Hong
KH
Zhang
Xin-Mei
XM
Zhou
Cai-Yun
CY
Huang
Xiu-Feng
XF
D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D015153:Blotting, Western; D004715:Endometriosis / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism / Q000502:physiology*; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism / Q000502:physiology*; D014591:Uterine Diseases / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
D015415:Biomarkers; D009363:Neoplasm Proteins; C484730:PTP4A3 protein, human; D017027:Protein Tyrosine Phosphatases