title: Hypertrophic cardiomyopathy. A study of the troponin-T gene in 127 Spanish families.
abstract: The information available on the correlation between genotype and phenotype and the prognostic implications of different troponin-T gene mutations is sparse and, at times, contradictory. We studied the TNNT2 gene in 127 patients with hypertrophic cardiomyopathy and identified three mutations in patients from four families (3.1%): the Phe87Leu mutation, which has not been previously reported, the Arg278Cys mutation (two families) and the Asp271Ile mutation. Seven carriers of the Phe87Leu mutation (aged 29 to 52 years) were found to have mild hypertrophy (i.e., a wall thickness <16 mm). There were 11 deaths associated with the condition (seven sudden deaths), and four of those who died were aged between 14 and 16 years. No sudden deaths occurred in the other three families. In conclusion, troponin-T mutations were responsible for 3% of the hypertrophic cardiomyopathy cases in our study population. The Phe87Leu mutation was associated with only mild hypertrophy but with a high risk of sudden death.
authors.affiliation: Servicio de Cardiología, Hospital Virgen de la Arrixaca, El Palmar, Murcia, España. jgimeno@secardiologia.es
authors.forename: Juan R
authors.initials: JR
authors.lastname: Gimeno
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Monserrat
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Pérez-Sánchez
authors.forename: Francisco
authors.initials: F
authors.lastname: Marín
authors.forename: Luis
authors.initials: L
authors.lastname: Caballero
authors.forename: Manuel
authors.initials: M
authors.lastname: Hermida-Prieto
authors.forename: Alfonso
authors.initials: A
authors.lastname: Castro
authors.forename: Mariano
authors.initials: M
authors.lastname: Valdés
mesh_terms: D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D010375:Pedigree; D013030:Spain; D020107:Troponin T / Q000235:genetics*
chemical_list: D020107:Troponin T