title: Radiofrequency ablation is a feasible therapeutic option in the multi modality management of sarcoma.
abstract: The role of radiofrequency ablation (RFA) in metastatic sarcoma is not well defined. The aim of this study was to evaluate the efficacy and safety of RFA in a series of sarcoma patients. A retrospective search of a prospectively maintained database identified 13 gastrointestinal stromal tumour (GIST) patients and 12 with other histological subtypes treated with RFA. All the GIST patients received RFA for metastatic disease in the liver: 12 of these responded to the first RFA procedure and one achieved stable disease. Two GIST patients received RFA on two occasions to separate lesions within the liver and both responded to the second RFA procedure. Of the other subtypes: 7 underwent RFA to liver lesions, 5 of these responded to RFA, one progressed and 1 was not assessable for response at the time of analysis. All 5 patients with lung metastases achieved a response following their first RFA procedure. RFA was effective and well tolerated in this series of sarcoma patients. RFA may have a role in patients with GIST who have progression in a single metastasis but stable disease elsewhere. Further larger studies are required to better define the role of this technique in this patient population.
authors.affiliation: Sarcoma Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK. robin.jones@icr.ac.uk
authors.forename: R L
authors.initials: RL
authors.lastname: Jones
authors.forename: J
authors.initials: J
authors.lastname: McCall
authors.forename: A
authors.initials: A
authors.lastname: Adam
authors.forename: D
authors.initials: D
authors.lastname: O'Donnell
authors.forename: S
authors.initials: S
authors.lastname: Ashley
authors.forename: O
authors.initials: O
authors.lastname: Al-Muderis
authors.forename: K
authors.initials: K
authors.lastname: Thway
authors.forename: C
authors.initials: C
authors.lastname: Fisher
authors.forename: I R
authors.initials: IR
authors.lastname: Judson
mesh_terms: D000328:Adult; D000368:Aged; D017115:Catheter Ablation; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000556:secondary / Q000601:surgery*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery*; D008175:Lung Neoplasms / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012509:Sarcoma / Q000556:secondary / Q000601:surgery*; D016896:Treatment Outcome