title: Chromosomal abnormalities of clear cell renal cell carcinoma: frequent gain of chromosome 7.
abstract: Gain of chromosome 7 is well known to be a characteristic abnormality of papillary renal cell carcinoma (RCC). The purpose of the present study was to perform cytogenetic analysis of G-band karyotype in 16 clear cell RCC obtained from nephrectomy. The age of patients ranged from 50 to 79 years and the tumor size in largest dimension ranged from 1.8 to 6.2 cm. As a result, the structural abnormality of chromosome 3 was most frequently observed (eight clones). Loss of chromosome 3 and gain of chromosome 7 followed (four clones). Among four clones showing gain of chromosome 7, two were associated with the abnormality of chromosome 3 and the remaining two were devoid of the abnormalities of chromosome 3. In addition, none of all four tumors showing gain of chromosome 7 demonstrated any foci of papillary growth pattern. The present study shows that gain of chromosome 7 is not exclusive to papillary RCC, but it can be found in clear cell RCC as well, and this finding may represent a diagnostic pitfall in distinguishing clear cell RCC from papillary RCC.
authors.affiliation: Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi 780-8562, Japan. kurochankochi@yahoo.co.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Kuroda
authors.forename: Masato
authors.initials: M
authors.lastname: Tamura
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shiotsu
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Nakamura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Taguchi
authors.forename: Akira
authors.initials: A
authors.lastname: Tominaga
authors.forename: Ondrej
authors.initials: O
authors.lastname: Hes
authors.forename: Michal
authors.initials: M
authors.lastname: Michal
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kawada
authors.forename: Taro
authors.initials: T
authors.lastname: Shuin
authors.forename: Gang-Hong
authors.initials: GH
authors.lastname: Lee
mesh_terms: D000368:Aged; D015820:Cadherins / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000378:metabolism; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D053552:Keratin-7 / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D007680:Kidney Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D015260:Neprilysin / Q000378:metabolism; D019998:Racemases and Epimerases / Q000378:metabolism; D014314:Trisomy / Q000235:genetics*
chemical_list: D015820:Cadherins; D053552:Keratin-7; D015260:Neprilysin; D019998:Racemases and Epimerases; C108352:alpha-methylacyl-CoA racemase