title: [The preventive effect of 23-valent pneumococcal polysaccharide vaccine against drug-resistant Streptococcus pneumonia in patients with chronic respiratory disease].
abstract: OBJECTIVE
  To elucidate the preventive effect of 23-valent pneumococcal polysaccharide vaccine (PV) on drug-resistant Streptococcus pneumoniae.
  
  
  METHODS
  Participants (outpatients, over 60 years of age, and with chronic lung disease) were interviewed and divided into two groups: the PV-vaccinated group (n=722) and the non-vaccinated group (n=872). The antimicrobial susceptibility and the genotype of antibiotic-resistant genes among the isolated pneumococcal strains from sputum before and after vaccination were studied.
  
  
  RESULTS
  The number of the isolated strains was as follows: prior to the vaccination, 24 isolates in the vaccinated group, 18 isolates in the non-vaccinated group; after vaccination (within 5 years), 53 isolates in the vaccinated group, 46 isolated in the non-vaccinated group. The PV decreased the frequency of Penicillin G-resistant strains successfully (from 16.7 to 7.5%) in the vaccinated group while the frequency increased (from 5.5 to 15.2%) in the non-vaccinated group during the same period. In genetic analysis, the rates of strains with altered pbpla, pbp2x and pbp2b were decreased in the vaccinated group than the non-vaccinated group (28.6% versus 53.3%).
  
  
  CONCLUSIONS
  The 23-valent pneumococcal polysaccharide vaccine may have a preventive effect against drug-resistant Streptococcus pneumoniae.
authors.affiliation: Department of Respiratory Medicine, Yokohama City University Hospital.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Watanuki
authors.forename: Naoki
authors.initials: N
authors.lastname: Miyazawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Kudo
authors.forename: Satoshi
authors.initials: S
authors.lastname: Inoue
authors.forename: Takashi
authors.initials: T
authors.lastname: Sato
authors.forename: Kei
authors.initials: K
authors.lastname: Mishina
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kaneko
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000150:complications*; D008297:Male; D022242:Pneumococcal Vaccines / Q000276:immunology*; D011018:Pneumonia, Pneumococcal / Q000235:genetics / Q000517:prevention & control*; D013296:Streptococcus pneumoniae / Q000187:drug effects; D014611:Vaccination
chemical_list: D022242:Pneumococcal Vaccines