Enantioselective desymmetrization of diphenylphosphinamides via (-)-sparteine-mediated ortho-lithiation. Synthesis of P-chiral ligands.
Asymmetric ortho-lithiation of N-dialkyl-P,P-diphenylphosphinamides using [n-BuLi.(-)-sparteine] is described as an efficient method for the synthesis of P-chiral ortho-functionalized derivatives in high yields and ee's from 45 to >99%. The method allows access to new enantiomerically pure P-chiral phosphine and diimine ligands.
Popovici
Cristinel
C
Area de Química Orgánica, Universidad de Almería, Carretera de Sacramento s/n, 04120 Almería, Spain.
Oña-Burgos
Pascual
P
Fernández
Ignacio
I
Roces
Laura
L
García-Granda
Santiago
S
Iglesias
María José
MJ
López Ortiz
Fernando
F