Effects of isoflurane upon minimum alveolar concentration and cerebral cortex depression in pigs and goats: an interspecies comparison.
This study compared the effects of isoflurane in pigs (n=10 Yorkshire-Landrace cross) and dairy goats (n=10) by evaluation of electroencephalographic (EEG) burst suppression thresholds (BST) in the cerebral cortex and minimum alveolar concentration (MAC) values in the spinal cord. The study also investigated whether individual MAC values can predict the effects of isoflurane on the cerebral cortex. MAC values and BST/MAC ratios were significantly different between species. Inhibition of movement by isoflurane may be less effective in pigs than in goats. No significant correlation was found between individual MAC and BST values, indicating that in single animals the individual MAC poorly reflects the cerebrocortical depressant effect of isoflurane in pigs and goats.
Haga
Henning A
HA
Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway. andreas.haga@veths.no
Ranheim
Birgit
B
Spadavecchia
Claudia
C
D000769:Anesthesia, Inhalation / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D004569:Electroencephalography / Q000187:drug effects / Q000662:veterinary*; D005260:Female; D006041:Goats; D007530:Isoflurane / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D011650:Pulmonary Alveoli / Q000378:metabolism*; D013045:Species Specificity; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology; D013552:Swine
D018685:Anesthetics, Inhalation; D007530:Isoflurane