title: Supramolecular hydrogel of a D-amino acid dipeptide for controlled drug release in vivo.
abstract: A supramolecular hydrogel based on D-amino acids, which resists hydrolysis catalyzed by proteinase K and offers long-term biostability, exhibits controlled release in vivo, as proved by the pharmacokinetics of encapsulated 125I tracers and the SPECT imaging of the hydrogel-encapsulated 131I tracers. As the first in vivo imaging investigation of the drug release properties of the supramolecular hydrogel, isotope encapsulation serves as a valid, useful assay for characterizing the controlled release properties of supramolecular hydrogels in vivo. Our results indicate that supramolecular hydrogels promise new biomaterials for controlled drug release.
authors.affiliation: Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China.
authors.forename: Gaolin
authors.initials: G
authors.lastname: Liang
authors.forename: Zhimou
authors.initials: Z
authors.lastname: Yang
authors.forename: Rongjun
authors.initials: R
authors.lastname: Zhang
authors.forename: Lihua
authors.initials: L
authors.lastname: Li
authors.forename: Yijun
authors.initials: Y
authors.lastname: Fan
authors.forename: Yi
authors.initials: Y
authors.lastname: Kuang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.forename: W William
authors.initials: WW
authors.lastname: Lu
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D004151:Dipeptides / Q000737:chemistry*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry; D007457:Iodine Radioisotopes / Q000737:chemistry; D008422:Materials Testing; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008956:Models, Chemical; D012974:Sodium Iodide / Q000737:chemistry; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D000596:Amino Acids; D001672:Biocompatible Materials; D004151:Dipeptides; D004337:Drug Carriers; D020100:Hydrogels; D007457:Iodine Radioisotopes; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D012974:Sodium Iodide