[Chemotherapy for Bolivian hemorrhagic fever in experimentally infected guinea pigs].
The efficacy of the antiviral agents nucleoside analogues manufactured in Russia and foreign countries against Bolivian hemorrhagic fever in the treatment and rapid prevention regimens was studied in guinea pigs. In rapid prevention and treatment of guinea pigs, the intraperitoneal injection of 1/10 of the equivalent dose of vero-ribavirin for this animal species was ascertained to protect 70% of the animals infected with Machupo virus strain Carvallo in doses 8 and 10 LD50.
Syromiatnikova
S I
SI
Khmelev
A L
AL
Pantiukhov
V B
VB
Shatokhina
I V
IV
Pirozhkov
A P
AP
Khamitov
R A
RA
Markov
V I
VI
Birisevich
I B
IB
Bondarev
V P
VP
D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006477:Arenaviruses, New World / Q000187:drug effects*; D002214:Capsules; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006478:Hemorrhagic Fever, American / Q000188:drug therapy*; D007274:Injections, Intraperitoneal; D008297:Male; D012254:Ribavirin / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D000998:Antiviral Agents; D002214:Capsules; D012254:Ribavirin