title: Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice.
abstract: Helicobacter pylori-induced gastritis is the strongest singular risk factor for gastric adenocarcinoma. Matrix metalloproteinase-7 (MMP-7) is a proteolytic enzyme that can modify the intestinal microbial replicative niche as well as affect tumorigenesis, and H. pylori stimulates expression of MMP-7 in gastric epithelial cells in vitro. Utilizing a transgenic murine model of H. pylori-mediated injury, our experiments now show that gastric inflammation is increased within the context of MMP-7 deficiency, which involves both Th1- and Th17-mediated pathways. Enhanced gastritis in H. pylori-infected mmp-7-/- mice is strongly linked to accelerated epithelial cellular turnover. However, more severe inflammation and heightened proliferation and apoptosis are not dependent on MMP-7-mediated bacterial eradication. Collectively, these studies indicate that H. pylori-mediated induction of MMP-7 may serve to protect the gastric mucosa from pathophysiologic processes that promote carcinogenesis.
authors.affiliation: Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232-2279, USA.
authors.forename: Seth R
authors.initials: SR
authors.lastname: Ogden
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Noto
authors.forename: Shannon S
authors.initials: SS
authors.lastname: Allen
authors.forename: Dilan A
authors.initials: DA
authors.lastname: Patel
authors.forename: Judith
authors.initials: J
authors.lastname: Romero-Gallo
authors.forename: M Kay
authors.initials: MK
authors.lastname: Washington
authors.forename: Barbara
authors.initials: B
authors.lastname: Fingleton
authors.forename: Dawn A
authors.initials: DA
authors.lastname: Israel
authors.forename: Nuruddeen D
authors.initials: ND
authors.lastname: Lewis
authors.forename: Keith T
authors.initials: KT
authors.lastname: Wilson
authors.forename: Rupesh
authors.initials: R
authors.lastname: Chaturvedi
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zhao
authors.forename: Yu
authors.initials: Y
authors.lastname: Shyr
authors.forename: Richard M
authors.initials: RM
authors.lastname: Peek
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology / Q000382:microbiology; D000818:Animals; D005753:Gastric Mucosa / Q000201:enzymology / Q000382:microbiology; D005756:Gastritis / Q000201:enzymology* / Q000382:microbiology; D016481:Helicobacter Infections / Q000201:enzymology*; D016480:Helicobacter pylori; D007150:Immunohistochemistry; D020783:Matrix Metalloproteinase 7 / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D011230:Precancerous Conditions / Q000201:enzymology* / Q000382:microbiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000201:enzymology / Q000382:microbiology
chemical_list: D020783:Matrix Metalloproteinase 7