title: [Study on the preparation of sustained-release pellets containing active components from Gastrodia elata by fluid-bed coating].
abstract: OBJECTIVE
  To study the formulation of sustained-release pellets containing active components from Gastrodia elata by coating in the fluid-bed.
  
  
  METHODS
  The sustained-release pellets were prepared with Eudragit RS 100. The formulation was optimized by the direct comparison. Then their properties were evaluated.
  
  
  RESULTS
  The pellets presented the perfect sphericity and narrow diameter distribution and the curve of their cumulative drug release was in accord with Higuchi equation.
  
  
  CONCLUSIONS
  The pellets have sustained-release effect in 12 hours.
authors.affiliation: Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of TCM, Shanghai 201203, China. hfuir@163.com
authors.forename: Yan-long
authors.initials: YL
authors.lastname: Hong
authors.forename: Xiao
authors.initials: X
authors.lastname: Lin
authors.forename: De-sheng
authors.initials: DS
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: Jun-song
authors.initials: JS
authors.lastname: Li
authors.forename: Ya-jun
authors.initials: YJ
authors.lastname: Zhang
mesh_terms: D000180:Acrylic Resins; D001592:Benzyl Alcohols / Q000032:analysis / Q000737:chemistry* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000493:pharmacokinetics; D031668:Gastrodia / Q000737:chemistry*; D005960:Glucosides / Q000032:analysis / Q000737:chemistry* / Q000493:pharmacokinetics; D008863:Microspheres; D010946:Plants, Medicinal / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*
chemical_list: D000180:Acrylic Resins; D001592:Benzyl Alcohols; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D011108:Polymers; C050528:Eudragit RS; C045345:gastrodin