title: The many roles of microRNAs in brain tumor biology.
abstract: MicroRNAs (miRNAs) are now recognized as the primary RNAs involved in the purposeful silencing of the cell's own message. In addition to the established role of miRNAs as developmental regulators of normal cellular function, they have recently been shown to be important players in pathological states such as cancer. The authors review the literature on the role of miRNAs in the formation and propagation of gliomas and medulloblastomas, highlighting the potential of these molecules and their inhibitors as therapeutics.
authors.affiliation: Division of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona, USA.
authors.forename: Jay D
authors.initials: JD
authors.lastname: Turner
authors.forename: Richard
authors.initials: R
authors.lastname: Williamson
authors.forename: Kaith K
authors.initials: KK
authors.lastname: Almefty
authors.forename: Peter
authors.initials: P
authors.lastname: Nakaji
authors.forename: Randall
authors.initials: R
authors.lastname: Porter
authors.forename: Victor
authors.initials: V
authors.lastname: Tse
authors.forename: M Yashar S
authors.initials: MY
authors.lastname: Kalani
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D001932:Brain Neoplasms / Q000235:genetics* / Q000503:physiopathology* / Q000628:therapy; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing / Q000502:physiology; D005910:Glioma / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D008527:Medulloblastoma / Q000235:genetics / Q000503:physiopathology; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D055495:Neurogenesis / Q000235:genetics / Q000502:physiology
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs