title: Triterpenoids from Camellia japonica and their cytotoxic activity.
abstract: From the ethyl acetate fraction of the stem bark of Camellia japonica, three new triterpenoids, 3beta-O-acetyl-16beta-hydroxy-12-oxoolean (6), 3beta-O-acetyl-16beta-hydroxy-11-oxoolean-12-ene (7), and 3beta-O-acetyl-16beta-hydroxyolean-12-ene (8), along with seven known compounds, 3alpha-hydroxy-1-oxofriedelan (1), friedelin (2), 3beta-friedelanol (3), canophyllol (4), 3-oxofriedelan-1(2)-ene (5), beta-amyrin (9), camellenodiol (10), and camelledionol (11) were isolated. Their structures were established on the basis of spectroscopic analysis and chemical evidence. The isolated compounds were tested in vitro for their cytotoxic activities against the A549, LLC, HL-60 and MCF-7 cancer cell lines. Among them, compound 8 showed cytotoxicity against LLC and HL-60 cancer cell lines with IC(50) values of 25.2 and 21.7 microM, respectively.
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Korea.
authors.forename: Nguyen Thi Phuong
authors.initials: NT
authors.lastname: Thao
authors.forename: Tran Manh
authors.initials: TM
authors.lastname: Hung
authors.forename: Mi Kyoung
authors.initials: MK
authors.lastname: Lee
authors.forename: Jin Cheol
authors.initials: JC
authors.lastname: Kim
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
authors.forename: KiHwan
authors.initials: K
authors.lastname: Bae
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D028244:Camellia / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D024301:Plant Bark / Q000737:chemistry; D014315:Triterpenes / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes