title: Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient.
abstract: We describe the acquisition of flucytosine, azole, and caspofungin resistance in sequential Candida glabrata bloodstream isolates collected from a bone marrow transplant patient with clinical failure. Point mutations in C. glabrata FUR1 (CgFUR1) and CgFKS2 and overexpression of CgCDR1 and CgCDR2 were observed in resistant isolates.
authors.affiliation: EA 209-Eucaryotes Pathogènes: Transports Membranaires et Chimiorésistance, Université Paris Descartes, Paris, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Chapeland-Leclerc
authors.forename: Christophe
authors.initials: C
authors.lastname: Hennequin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Papon
authors.forename: Thierry
authors.initials: T
authors.lastname: Noël
authors.forename: Aurélie
authors.initials: A
authors.lastname: Girard
authors.forename: Gérard
authors.initials: G
authors.lastname: Socié
authors.forename: Patricia
authors.initials: P
authors.lastname: Ribaud
authors.forename: Claire
authors.initials: C
authors.lastname: Lacroix
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology; D041221:Candida glabrata / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology; D000077336:Caspofungin; D002648:Child; D025141:Drug Resistance, Fungal / Q000235:genetics; D054714:Echinocandins / Q000494:pharmacology; D005260:Female; D005437:Flucytosine / Q000494:pharmacology; D005656:Fungal Proteins / Q000235:genetics; D016469:Fungemia / Q000382:microbiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D017354:Point Mutation
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D054714:Echinocandins; D005656:Fungal Proteins; D055666:Lipopeptides; D005437:Flucytosine; D000077336:Caspofungin