title: An unusual cause of posterior fossa mass: Lhermitte-Duclos disease.
abstract: Lhermitte-Duclos disease (LDD) (dysplastic cerebellar gangliocytoma) is a rare disorder of unknown pathogenesis, presenting with signs and symptoms resulting from obstruction of cerebrospinal fluid flow and mass effect in the posterior fossa. Magnetic resonance imaging is the diagnostic modality of choice allowing preoperative diagnosis with characteristic findings. Surgery is the choice of treatment. The typical histopathological findings of LDD are characterized by widening of the molecular layer, absence of the Purkinje cell layer and hypertrophy in the granule cell layer. Herein we report an adolescent girl with LDD diagnosed preoperatively by the conventional and advanced MR techniques.
authors.affiliation: Department of Pediatric Oncology, Hacettepe University Institute of Oncology, 06100 Ankara, Turkey. drbegul@yahoo.com
authors.forename: Begül
authors.initials: B
authors.lastname: Yağci-Küpeli
authors.forename: Kader K
authors.initials: KK
authors.lastname: Oguz
authors.forename: M Asim
authors.initials: MA
authors.lastname: Bilen
authors.forename: Bilgehan
authors.initials: B
authors.lastname: Yalçin
authors.forename: Nejat
authors.initials: N
authors.lastname: Akalan
authors.forename: Münevver
authors.initials: M
authors.lastname: Büyükpamukçu
mesh_terms: D000293:Adolescent; D002528:Cerebellar Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D003388:Cranial Fossa, Posterior / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D020546:Fourth Ventricle / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006223:Hamartoma Syndrome, Multiple / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D006261:Headache / Q000209:etiology; D006801:Humans; D006849:Hydrocephalus / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D019586:Intracranial Hypertension / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D019635:Neurosurgical Procedures; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome