title: Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis.
abstract: Finding a way to combine ultrasound and fluorescence optical imaging on an endorectal probe may improve early detection of prostate cancer. The ultrasound provides morphological information about the prostate, while the optical system detects and locates fluorophore-marked tumors. A tissue-mimicking phantom, which is representative of prostate tissues both on its optical (absorption mu(a) and diffusion mu(s) (')) and its ultrasound properties, has been made by our team. A transrectal probe adapted to fluorescence diffuse optical tomography measurements was also developed. Measurements were taken on the prostate phantom with this probe based on a pulsed laser and a time-resolved detection system. A reconstruction algorithm was then used to help locate and quantify fluorescent inclusions of different concentrations at fixed depths.
authors.affiliation: Département des Micro-Technologies pour la Biologie et la Santé, CEA-LETI-MINATEC French Atomic Energy Comission, 17 rue des Martyrs, Grenoble, F38054, France. jerome.boutet@cea.fr
authors.forename: Jerome
authors.initials: J
authors.lastname: Boutet
authors.forename: Lionel
authors.initials: L
authors.lastname: Herve
authors.forename: Mathieu
authors.initials: M
authors.lastname: Debourdeau
authors.forename: Laurent
authors.initials: L
authors.lastname: Guyon
authors.forename: Philippe
authors.initials: P
authors.lastname: Peltie
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Dinten
authors.forename: Laurent
authors.initials: L
authors.lastname: Saroul
authors.forename: Francois
authors.initials: F
authors.lastname: Duboeuf
authors.forename: Didier
authors.initials: D
authors.lastname: Vray
mesh_terms: D004867:Equipment Design; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D019047:Phantoms, Imaging; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D012815:Signal Processing, Computer-Assisted; D013050:Spectrometry, Fluorescence / Q000295:instrumentation / Q000379:methods*; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods*