The threshold of amylin-induced anorexia is lower in chicks selected for low compared to high juvenile body weight.
Chicks that have undergone long-term selection for low body weight responded to intracerebroventricular amylin injection with reduced food intake at a dose considerably lower and with a greater magnitude suppression than those selected for high body weight. Behaviors unrelated to ingestion were not affected. These data support the thesis of correlated amylin system responses to selection for low or high body weight, with possible implications to other species.
Cline
Mark A
MA
Department of Biology, Radford University, Radford, VA 24142, USA. mcline@radford.edu
Nandar
Wint
W
Bowden
Christie
C
Calchary
Wendy
W
Smith
Marissa L
ML
Prall
Brian
B
Newmyer
Brandon
B
Orion Rogers
J
J
Siegel
Paul B
PB
D000367:Age Factors; D000682:Amyloid / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D000855:Anorexia / Q000139:chemically induced*; D001067:Appetite Depressants / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects* / Q000235:genetics; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D007276:Injections, Intraventricular / Q000379:methods; D058228:Islet Amyloid Polypeptide; D013997:Time Factors
D000682:Amyloid; D001067:Appetite Depressants; D058228:Islet Amyloid Polypeptide