Increased serum YKL-40 and C-reactive protein levels are associated with angiographic lesion progression in patients with coronary artery disease.
OBJECTIVE
YKL-40 is a pro-inflammatory protein highly expressed in atherosclerotic plaques, and is related to prognosis of patients with coronary artery disease (CAD). This study aimed to assess the possible association between YKL-40 and coronary lesion progression in CAD patients.


METHODS
A total of 313 patients with CAD, who underwent percutaneous coronary intervention (PCI) and follow-up angiography (mean 13.2+/-3.2 months) were recruited. Serum YKL-40 and high-sensitivity C-reactive protein (hsCRP) levels were measured using ELISA kits.


RESULTS
Baseline serum YKL-40 and hsCRP levels were higher in those with lesion progression (all p<0.001 vs. patients without lesion progression), and correlated significantly with change of lumen diameter stenosis and cumulative coronary obstruction score (all p<0.01). Multivariable logistic regression analysis revealed that after adjusting for conventional risk factors, number of total coronary artery lesions, YKL-40 and hsCRP levels were independent determinants of lesion progression. An area under the curve of YKL-40 and hsCRP was 0.744 (CI 95% 0.685-0.804, p<0.001) and 0.716 (CI 95% 0.657-0.776, p<0.001), respectively. The optimal values of cut-off point were 74.98 ng/ml (sensitivity 70%, specificity 71%) for YKL-40 and 3.21 mg/l (sensitivity 66%, specificity 68%) for hsCRP to predict lesion progression.


CONCLUSIONS
Increased serum YKL-40 and hsCRP levels are independently associated with lesion progression in patients with CAD.
Zheng
Jian Lei
JL
Department of Cardiology, Rui Jin Hospital, Jiaotong University School of Medicine, Shanghai 200025, PR China.
Lu
Lin
L
Hu
Jian
J
Zhang
Rui Yan
RY
Zhang
Qi
Q
Chen
Qiu Jin
QJ
Shen
Wei Feng
WF
D054392:Adipokines; D000368:Aged; D000792:Angiography / Q000379:methods*; D015906:Angioplasty, Balloon, Coronary; D002097:C-Reactive Protein / Q000096:biosynthesis*; D000071451:Chitinase-3-Like Protein 1; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000473:pathology; D018450:Disease Progression; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007249:Inflammation; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors
D054392:Adipokines; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D006023:Glycoproteins; D037102:Lectins; D002097:C-Reactive Protein