title: Antihypertensive effect of a gamma-aminobutyric acid rich tomato cultivar 'DG03-9' in spontaneously hypertensive rats.
abstract: This study aimed to investigate the effects of a gamma-aminobutyric acid (GABA) rich tomato (Solanum lycopersicum L.) cultivar 'DG03-9' in comparison with 'Momotaro', a commonly consumed tomato cultivar in Japan, on systolic blood pressure (SBP) in spontaneously hypertensive rats (SHR). In a single administration study, treatment with the GABA-rich cultivar elicited a significant decrease in SBP compared to the control group. In a chronic administration study, SHR were fed diets containing one of the tomato cultivars for 4 weeks. Both cultivars significantly reduced the increase in SBP compared to the control. The antihypertensive effect of the GABA-rich cultivar was higher than that of the commonly consumed cultivar in both the single- and chronic-administration studies. Treatment with a comparable amount of GABA elicited a similar response to treatment with the GABA-rich cultivar. These results suggest that the GABA-rich cultivar 'DG03-9' is a potent antihypertensive food and may be useful for treating hypertension effectively.
authors.affiliation: Research and Development Division, Kikkoman Corporation, 399 Noda, Noda City, Chiba 278-0039, Japan. myoshimura@mail.kikkoman.co.jp
authors.forename: Mineka
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Tohru
authors.initials: T
authors.lastname: Toyoshi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sano
authors.forename: Toru
authors.initials: T
authors.lastname: Izumi
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujii
authors.forename: Chiaki
authors.initials: C
authors.lastname: Konishi
authors.forename: Shuji
authors.initials: S
authors.lastname: Inai
authors.forename: Chiaki
authors.initials: C
authors.lastname: Matsukura
authors.forename: Naoya
authors.initials: N
authors.lastname: Fukuda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ezura
authors.forename: Akio
authors.initials: A
authors.lastname: Obata
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D018551:Solanum lycopersicum / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D011918:Rats, Inbred SHR; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage*
chemical_list: D000959:Antihypertensive Agents; D010936:Plant Extracts; D005680:gamma-Aminobutyric Acid