title: Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment.
abstract: The supposed role of cardiac sigma receptors is fine tuning of contractility. Sigma receptors affect several ionic channels and hence their signaling is reflected by the electrophysiological properties of the heart. Numerous ligands of sigma receptors are known to prolong the QT interval and therefore cause a variety of arrhythmias, including severe ones. The effects of the prototypical sigma ligand haloperidol have been studied extensively in humans as well as in various animal models, primarily after acute administration. We examined the incidence of arrhythmias, changes in heart rate, and prolongation of QT interval in isolated Langendorff-perfused rat and guinea pig hearts after they were exposed to nanomolar concentrations of haloperidol. Hearts from both untreated (acute) and pretreated (chronic) animals were investigated. While QT prolongation and arrhythmias due to haloperidol administration were observed in untreated rat and guinea pig hearts, arrhythmias were completely prevented in both species of chronically treated animals. In treated guinea pigs, the results were generally less convincing. Since the hearts were exposed to nanomolar concentration of haloperidol, we conclude that our data may be explained by desensitization of sigma receptors.
authors.affiliation: Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors.forename: Katerina
authors.initials: K
authors.lastname: Fialova
authors.forename: Olga
authors.initials: O
authors.lastname: Krizanova
authors.forename: Jiri
authors.initials: J
authors.lastname: Jarkovsky
authors.forename: Marie
authors.initials: M
authors.lastname: Novakova
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology; D004562:Electrocardiography / Q000187:drug effects; D006168:Guinea Pigs; D006220:Haloperidol / Q000378:metabolism / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D017480:Receptors, sigma / Q000187:drug effects* / Q000502:physiology; D016171:Torsades de Pointes / Q000139:chemically induced / Q000503:physiopathology
chemical_list: D017480:Receptors, sigma; D006220:Haloperidol