title: Acute encephalopathy associated with influenza A infection in adults.
abstract: We report acute encephalopathy associated with influenza A infection in 3 adults. We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios > or =3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. Patients recovered without sequelae. Hyperactivated cytokine response may play a role in pathogenesis.
authors.affiliation: Division of Infectious Diseases, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 9/F Clinical Sciences Building, Department of Medicine and Therapeutics, Shatin, Hong Kong, People's Republic of China. leelsn@cuhk.edu.hk
authors.forename: Nelson
authors.initials: N
authors.lastname: Lee
authors.forename: Chun Kwok
authors.initials: CK
authors.lastname: Wong
authors.forename: Paul K S
authors.initials: PK
authors.lastname: Chan
authors.forename: Niklas
authors.initials: N
authors.lastname: Lindegardh
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
authors.forename: Frederick G
authors.initials: FG
authors.lastname: Hayden
authors.forename: Edward H C
authors.initials: EH
authors.lastname: Wong
authors.forename: Ka Shing
authors.initials: KS
authors.lastname: Wong
authors.forename: Clive S
authors.initials: CS
authors.lastname: Cockram
authors.forename: Joseph J Y
authors.initials: JJ
authors.lastname: Sung
authors.forename: David S C
authors.initials: DS
authors.lastname: Hui
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016207:Cytokines / Q000502:physiology; D018792:Encephalitis, Viral / Q000150:complications / Q000821:virology*; D005260:Female; D006801:Humans; D009980:Influenza A virus; D007251:Influenza, Human / Q000150:complications / Q000821:virology*; D008297:Male
chemical_list: D016207:Cytokines