title: Three cases of reversible agranulocytosis after treatment with lamotrigine.
abstract: Several psychotropic drugs, including clozapine, are known to cause agranulocytosis and this may lead to a fatal condition. Lamotrigine is an anticonvulsant that the Food and Drug Administration (FDA) has approved for the depression of bipolar disorder. A few cases of lamotrigine-induced agranulocytosis have been previously reported on, but the pathophysiology and clinical manifestations are not yet known. This case series reports on 3 patients with different medical conditions who experienced agranulocytosis during treatment with lamotrigine. In these cases, the agranulocytosis occurred a few weeks after initiation of lamotrigine and it rapidly disappeared after discontinuation. We also discuss several characteristics of lamotrigine-induced agranulocytosis.
authors.affiliation: Department of Psychiatry, and Behavioral Science, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Yong Min
authors.initials: YM
authors.lastname: Ahn
authors.forename: Kunjong
authors.initials: K
authors.lastname: Kim
authors.forename: Yong Sik
authors.initials: YS
authors.lastname: Kim