title: Reduction in bacteremia rates after rectum sterilization before transrectal, ultrasound-guided prostate biopsy: a randomized controlled trial.
abstract: OBJECTIVE
  To determine the efficacy of rectum sterilization before TRUS guided prostate biopsy in order to decrease bacteremia rate and sepsis complication.
  
  
  METHODS
  From August 2008 to March 2009, 100 volunteers who had an indication for prostate biopsy were recruited into the present study in a randomized controlled trial. The present study was approved by the Ethics Committee on Human Experimentation of Ramathibodi Hospital Faculty of Medicine, Mahidol University. The volunteers received unison enema one day before and Ciprofloxacin 500 mg 0.5-1 hr before the procedure. These 100 volunteers were divided into two groups; 50 were randomly assigned in the group of rectum cleaning with 10% povidone-iodine, whereas the other 50 volunteers were placed in the control group. Twelve cores of TRUS guided prostate biopsy were performed After the procedure, peripheral blood samples were taken for cultures for aerobic and anaerobic bacteria. A clinical follow-up at 48-72 hrs after the procedure was done via telephone.
  
  
  RESULTS
  Hemocultures were positive for 9 cases in the rectum cleaning group and 2 cases in the control group (p = 0.025). Three volunteers (one in the rectum cleaning group and two in the control group) had a postoperative fever but it spontaneously resolved. Two volunteers in the control group came back to the hospital because of urinary tract infections and rectal bleeding. None of the volunteers had clinical sepsis or went to other hospitals.
  
  
  CONCLUSIONS
  Sterilization of the rectum before TRUS guided prostate biopsy was found to reduce postoperative bacteremia and might reduce clinical infections.
authors.affiliation: Division of Urology, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Panupong
authors.initials: P
authors.lastname: Kanjanawongdeengam
authors.forename: Wit
authors.initials: W
authors.lastname: Viseshsindh
authors.forename: Pitak
authors.initials: P
authors.lastname: Santanirand
authors.forename: Prapapan
authors.initials: P
authors.lastname: Prathombutr
authors.forename: Supannee
authors.initials: S
authors.lastname: Nilkulwattana
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D016470:Bacteremia / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D001706:Biopsy; D002939:Ciprofloxacin / Q000627:therapeutic use; D004733:Enema; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control; D011206:Povidone-Iodine / Q000627:therapeutic use; D011467:Prostate / Q000473:pathology / Q000601:surgery*; D011468:Prostatectomy / Q000379:methods; D012007:Rectum / Q000382:microbiology*; D013242:Sterilization; D013785:Thailand / Q000453:epidemiology
chemical_list: D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local; D002939:Ciprofloxacin; D011206:Povidone-Iodine