title: Secular trend of genome types of respiratory adenovirus type 3 during 1983-2005: a study from Taiwan.
abstract: Genome type analysis of adenovirus type 3 (Ad3) in Taiwan identified four types (Ad3a, Ad3a2, Ad3a1, Ad3-7) during 1983-2005. Ad3a was the major type during 1983-1999, while Ad3a2 was the predominant type from 2001 to 2005. Phylogenetic analysis of the hexon gene of 23 isolates revealed that most Ad3a2 and Ad3-7 isolates belonged to one cluster, and most Ad3a isolates to the other cluster. The clinical manifestations included respiratory tract infections, acute gastroenteritis, hand-foot-and-mouth disease, febrile convulsion and pharyngoconjunctival fever. In conclusion, Ad3a2 has replaced Ad3a as the most common genome type in Taiwan since 2001.
authors.affiliation: Department of Clinical Laboratory, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Yung-Cheng
authors.initials: YC
authors.lastname: Lin
authors.forename: Kuei-Hsiang
authors.initials: KH
authors.lastname: Lin
authors.forename: Guan-Ming
authors.initials: GM
authors.lastname: Ke
authors.forename: Min-Sheng
authors.initials: MS
authors.lastname: Lee
authors.forename: Pei-Chin
authors.initials: PC
authors.lastname: Lin
authors.forename: Hsin-Fu
authors.initials: HF
authors.lastname: Liu
authors.forename: Li-Ching
authors.initials: LC
authors.lastname: Hsu
authors.forename: Po-Liang
authors.initials: PL
authors.lastname: Lu
mesh_terms: D000256:Adenoviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D000293:Adolescent; D000328:Adult; D036022:Capsid Proteins / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D005260:Female; D016679:Genome, Viral; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D010802:Phylogeny; D012141:Respiratory Tract Infections / Q000821:virology*; D017421:Sequence Analysis; D013624:Taiwan; D014412:Tumor Virus Infections / Q000821:virology*; D055815:Young Adult
chemical_list: D036022:Capsid Proteins; C018315:hexon capsid protein, Adenovirus