title: Isolated recurrence of granulocytic sarcoma-two case reports-.
abstract: Two patients presented with rare isolated recurrence of granulocytic sarcoma. A 29-year-old male presented with an extra- and intracranial mass 10 years after bone marrow transplantation for chronic myeloid leukemia. A 34-year-old female presented with an intracranial mass 3 years after complete remission of acute myeloid leukemia-M2a. Both patients underwent surgical resection. The first patient received adequate postoperative radiotherapy and chemotherapy, and achieved complete remission without evidence of diseases during the 6-month follow up. The second patient only received whole brain radiotherapy, failed to respond, and died of systemic leukemia later. These two cases demonstrate that neurosurgeons should pay attention to the occurrence of isolated recurrent granulocytic sarcoma, especially in patients with a history of hematologic neoplasm. Immediate pathological and cytogenetic diagnoses are essential.
authors.affiliation: Department of Neurosurgery, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zheijaiang Province, P.R.C.
authors.forename: Qingsheng
authors.initials: Q
authors.lastname: Xu
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.forename: Qihan
authors.initials: Q
authors.lastname: You
authors.forename: Huafeng
authors.initials: H
authors.lastname: Wang
authors.forename: Ke
authors.initials: K
authors.lastname: Ye
authors.forename: Renya
authors.initials: R
authors.lastname: Zhan
authors.forename: Yongqing
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D001932:Brain Neoplasms / Q000209:etiology / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy / Q000379:methods; D004358:Drug Therapy; D042241:Early Diagnosis; D017809:Fatal Outcome; D005260:Female; D006258:Head and Neck Neoplasms / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000628:therapy; D019635:Neurosurgical Procedures; D011878:Radiotherapy; D023981:Sarcoma, Myeloid / Q000209:etiology* / Q000473:pathology*; D016896:Treatment Outcome; D055815:Young Adult