Asymmetric mannich reaction of malonates with imines catalyzed by a chiral calcium complex.
A chiral calcium complex was found to be effective for the Mannich reactions of malonates with N-Boc imines. The desired adducts were obtained in excellent yields (up to 95%) with moderate to good enantioselectivities (up to 77% ee).
Poisson
Thomas
T
Department of Chemistry, School of Science and Graduate School of Pharmaceutical Sciences, The University of Tokyo, The HFRE Division, ERATO, Japan Science and Technology Agency (JST), Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Tsubogo
Tetsu
T
Yamashita
Yasuhiro
Y
Kobayashi
Shū
S
D002118:Calcium / Q000737:chemistry*; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D008314:Malonates / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D007097:Imines; D008314:Malonates; D009942:Organometallic Compounds; D002118:Calcium