title: [Predictive factors for histopathological liver injury in the patients who received preoperative systemic chemotherapy for colorectal liver metastases].
abstract: The operation for liver metastases from colorectal cancer is increasing due to a progress of chemotherapy. On the other hand, the live damage induced by chemotherapy affects on post operative course. We studied histopathological liver injury on the patients who received preoperative chemotherapy. Between January 2004 and May 2009, forty seven patients underwent hepatectomy for colorectal liver metastases after systemic chemotherapy, and the remnant liver was histopathologically investigated about sinusoidal dilatation and non-alcoholic steatohepatitis. As a result, chemotherapy including irinotecan or oxaliplatin was significantly associated with sinusoidal dilatation, and female gender or higher body mass index was correlated with non-alcoholic steatohepatitis. These results should be taken into consideration before liver resection in patients who have received preoperative chemotherapy.
authors.affiliation: Department of Surgery, Hirosaki University School of Medicine.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kudo
authors.forename: Shinji
authors.initials: S
authors.lastname: Tsutsumi
authors.forename: Harue
authors.initials: H
authors.lastname: Akasaka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Jin
authors.forename: Taisei
authors.initials: T
authors.lastname: Ohashi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Muroya
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Hasebe
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Keinosuke
authors.initials: K
authors.lastname: Ishido
authors.forename: Motoi
authors.initials: M
authors.lastname: Koyama
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Toyoki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Murata
authors.forename: Shunji
authors.initials: S
authors.lastname: Narumi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kijima
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hakamada
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D015179:Colorectal Neoplasms / Q000473:pathology*; D005234:Fatty Liver / Q000139:chemically induced; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents