[Advances in the study of regulation of novel organic cation transporter-2].
Novel organic cation transporter-2 (OCTN2), a member of the organic cation transporter family, may transport carnitine and multiple organic cationic drugs. Thus OCTN2 possesses substantial roles in physiology and pharmacology. A number of researches have proven that many factors can regulate the expression and/or function of OCTN2 via different pathways, and then may affect the homeostasis and disposition of drugs. This paper reviews recent progresses in this field.
Wang
Fu-Rong
FR
Qilu Hospital Affiliated to Shandong University, Jinan 250012, China.
Guo
Rui-Chen
RC
D000818:Animals; D001692:Biological Transport; D002331:Carnitine / Q000378:metabolism*; D002352:Carrier Proteins / Q000502:physiology*; D002994:Clofibrate / Q000494:pharmacology*; D003092:Colitis / Q000378:metabolism*; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D008565:Membrane Proteins; D009154:Mutation; D027701:Organic Cation Transport Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D047493:PPAR alpha / Q000819:agonists; D012333:RNA, Messenger / Q000378:metabolism; D000074058:Solute Carrier Family 22 Member 5
D002352:Carrier Proteins; D008565:Membrane Proteins; D027701:Organic Cation Transport Proteins; C484659:PDZK1 protein, human; D047493:PPAR alpha; D012333:RNA, Messenger; C492020:SLC22A5 protein, human; D000074058:Solute Carrier Family 22 Member 5; D002994:Clofibrate; D002331:Carnitine