Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-L-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT.
A new phenylboric acid derivative entrapped lipiodol (PBAD-lipiodol) was developed as a boron carrier for the boron neutron capture therapy (BNCT) of hepatoma in Taiwan. The biodistribution of both PBAD-lipiodol and BPA-fructose was assayed in GP7TB hepatoma-bearing rat model. The highest uptake of PBAD-lipiodol was found at 2h post injection. The application of BNCT for the hepatoma treatment in tumor-bearing rats is suggested to be 2-4h post PBAD-lipiodol injection.
Liao
A H
AH
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.
Chou
F I
FI
Kuo
Y C
YC
Chen
H W
HW
Kai
J J
JJ
Chang
C W
CW
Chen
F D
FD
Hwang
J J
JJ
D000818:Animals; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001897:Boronic Acids / Q000138:chemical synthesis / Q000493:pharmacokinetics* / Q000494:pharmacology; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics* / Q000494:pharmacology; D007459:Iodized Oil / Q000138:chemical synthesis / Q000493:pharmacokinetics* / Q000494:pharmacology; D008114:Liver Neoplasms, Experimental / Q000378:metabolism* / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D008297:Male; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000502:physiology; D051381:Rats; D011916:Rats, Inbred F344; D014018:Tissue Distribution
D001897:Boronic Acids; D005462:Fluorine Radioisotopes; D010649:Phenylalanine; D007459:Iodized Oil