title: Lethality of endocarditis due to S. aureus among patients on hemodialysis.
abstract: This study evaluated the prevalence and risk factors for endocarditis in patients undergoing hemodialysis with central venous catheter (CVC) and to identify the microorganisms isolated from the bloodstream. This cohort study followed 94 patients with end stage renal disease (ESRD) who developed bacteremia after the insertion of a CVC for dialysis in the hospital São Paulo, UNIFESP, Brazil. They were divided into two groups: patients with endocarditis (E+) and patients without (E-). The prevalence of endocarditis was 29%. Among risk factors, the time of hospitalization and residence of the catheter were significantly higher (p < 0.001) in group E+. The mortality rate was 15%, and lethality of endocarditis was 55%. Of the 38 microorganisms isolated in group E+, 20 were S. aureus and 45% of those were MRSA. Group E+ with MRSA presented 100% mortality. High mortality and lethality in the E+ group was observed, and of the microorganisms isolated, MRSA was the most lethal. This article provides an overview of the findings of this study.
authors.affiliation: Department of Nursing, Federal University of São Paulo, São Paulo, Brazil. cibelegrothe@hotmail.com
authors.forename: Cibele
authors.initials: C
authors.lastname: Grothe
authors.forename: Angélica
authors.initials: A
authors.lastname: Belasco
authors.forename: Ana
authors.initials: A
authors.lastname: Bettencourt
authors.forename: Solange
authors.initials: S
authors.lastname: Diccini
authors.forename: Lucila
authors.initials: L
authors.lastname: Vianna
authors.forename: Antonio
authors.initials: A
authors.lastname: Pignatari
authors.forename: Ricardo
authors.initials: R
authors.lastname: Sesso
authors.forename: Dulce
authors.initials: D
authors.lastname: Barbosa
mesh_terms: D001938:Brazil / Q000453:epidemiology; D015331:Cohort Studies; D004697:Endocarditis, Bacterial / Q000382:microbiology / Q000401:mortality*; D006801:Humans; D015995:Prevalence; D006435:Renal Dialysis; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000382:microbiology / Q000401:mortality*; D013211:Staphylococcus aureus / Q000302:isolation & purification*