[Study on the inclusion of volatile oil extracted from Herba Pogostemonis and Exocarpium citri by beta-cyclodextrin].
OBJECTIVE
To investigate the inclusion technology conditions of volatile oil extracted from Herba Pogostemonis and Exocarpium citri in Huxin Fang granules by beta-cyclodextrin.


METHODS
The orthogonal design was used. The percent conversion of the oil in inclusion and the yield of inclusion complex were the indices to determine the factors containing the ratio of the oil to beta-cyclodextrin, the ratio of beta-cyclodextrin to water and the grinding time of the mixture of the oil, beta-cyclodextrin and water.


RESULTS
The optimum conditions for the inclusion were as follows: the ratio of the oil to beta-cyclodextrin was 1:10, the ratio of beta-cyclodextrin to water was 1:3, and the grinding time was 40 min.


CONCLUSIONS
The optimum conditions for the inclusion were steady and feasible.
Mu
Qi-yun
QY
The Second College of Clinical Medicine of Guangzhou University of TCM, Guangzhou 510120, China. muqiyun@yahoo.cn
Ruan
Xin-min
XM
D002957:Citrus / Q000737:chemistry*; D004337:Drug Carriers; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D005638:Fruit / Q000737:chemistry; D019686:Lamiaceae / Q000737:chemistry*; D009822:Oils, Volatile / Q000008:administration & dosage* / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature; D047392:beta-Cyclodextrins
D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D009822:Oils, Volatile; D047392:beta-Cyclodextrins