title: [A case of acute cholestatic hepatitis induced by Corydalis speciosa Max].
abstract: Herbs are widely used as treatments for various symptoms. However, several herbs have been reported to be inducers of liver injury. We report herein a case of hepatotoxicity induced by Corydalis speciosa Max. A 37-year-old male complained of jaundice and mild abdominal discomfort. A thorough history was taken, and laboratory investigation, diagnostic imaging studies, and percutaneous liver biopsy sampling were conducted to determine the cause of liver injury. An accurate cause was not revealed. We administered supportive management for acute cholestatic hepatitis of unknown origin, after which his symptoms disappeared and serum aminotransferase levels decreased gradually to near normal levels. However, at 2 months after discharge, the symptoms and the elevation of aminotransferase levels recurred. At that time he told us that he had repeatedly but unintentionally eaten a herb called "Hwang-geun cho"(Corydalis speciosa Max.). Thus, we diagnosed his case as herbal hepatotoxicity.
authors.affiliation: Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
authors.forename: Hyun Seok
authors.initials: HS
authors.lastname: Kang
authors.forename: Hyuk Soon
authors.initials: HS
authors.lastname: Choi
authors.forename: Tae Jung
authors.initials: TJ
authors.lastname: Yun
authors.forename: Kwang Gyun
authors.initials: KG
authors.lastname: Lee
authors.forename: Yeon Seok
authors.initials: YS
authors.lastname: Seo
authors.forename: Jong Eun
authors.initials: JE
authors.lastname: Yeon
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Byun
authors.forename: Soon Ho
authors.initials: SH
authors.lastname: Um
authors.forename: Chang Duck
authors.initials: CD
authors.lastname: Kim
authors.forename: Ho Sang
authors.initials: HS
authors.lastname: Ryu
mesh_terms: D000208:Acute Disease; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000473:pathology; D031311:Corydalis / Q000737:chemistry*; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000633:toxicity*; D014057:Tomography, X-Ray Computed
chemical_list: D010936:Plant Extracts; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin