Synthesis and evaluation of phenylequine for antimalarial activity in vitro and in vivo.
Synthesis of the potent antiplasmodial 4-aminoquinoline, phenylequine (PQ), is reported for the first time. PQ and the two analogues show increased efficacy in moving from the chloroquine sensitive D10 to the chloroquine resistant K1 strain in vitro. The in vivo efficacy of PQ, and salts thereof, have been determined in Plasmodium berghei ANKA and Plasmodium yoelii. Phenylequine hydrochloride has shown an ED(50) of 0.81 in P. yoelii (cf chloroquine ED(50)=1.31).
Blackie
Margaret A L
MA
Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
Yardley
Vanessa
V
Chibale
Kelly
K
D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D010963:Plasmodium falciparum / Q000187:drug effects / Q000502:physiology; D010967:Plasmodium yoelii / Q000187:drug effects / Q000502:physiology
D000634:Aminoquinolines; D000962:Antimalarials; C001920:4-aminoquinoline