title: Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptor.
abstract: Based on structural information for a peptide (P8-2KAQ) that binds to granulocyte-colony stimulating factor receptor (G-CSFR), small ligands with a biaryl scaffold were designed and their binding affinities were evaluated.
authors.affiliation: Department of Biological Science, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.
authors.forename: Radwan
authors.initials: R
authors.lastname: El-Haggar
authors.forename: Ken
authors.initials: K
authors.lastname: Kamikawa
authors.forename: Kazuya
authors.initials: K
authors.lastname: Machi
authors.forename: Zhengmao
authors.initials: Z
authors.lastname: Ye
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ishino
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsumuraya
authors.forename: Ikuo
authors.initials: I
authors.lastname: Fujii
mesh_terms: D015195:Drug Design; D018257:Helix-Loop-Helix Motifs / Q000502:physiology; D008968:Molecular Conformation; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding / Q000502:physiology; D011487:Protein Conformation; D016188:Receptors, Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D010455:Peptides; D016188:Receptors, Granulocyte Colony-Stimulating Factor