title: [Advanced lung cancer with mediastinal lymph node metastasis and recurrence of brain metastasis completely responsive to combination chemotherapy and gamma knife radiosurgery--a case report].
abstract: We report a case in which advanced lung cancer with mediastinal lymph node metastasis and recurrence of brain metastasis was completely responsive to combination chemotherapy and gamma knife radiosurgery. The patient was a 61-year-old woman, who suffered from advanced lung cancer (SCC) with bilateral mediastinal lymph node metastasis and contralateral lung nodule. She was treated with CBDCA combined with PTX. Bilateral lung nodules were surgically resected. Seven months after resection, solitary brain metastasis appeared, and gamma knife radiosurgery was performed. Histological efficacy of both primary lung tumor (SCC) and metastatic brain tumor was evaluated as Ef 3 (pCR). She has had no recurrence for 3 years after radiosurgery.
authors.affiliation: Department of Surgery, Nishinomiya Municipal Central Hospital.
authors.forename: Naozumi
authors.initials: N
authors.lastname: Higaki
authors.forename: Itsuro
authors.initials: I
authors.lastname: Soma
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Hayashi
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Nakano
authors.forename: Masakazu
authors.initials: M
authors.lastname: Murakami
authors.forename: Hirohito
authors.initials: H
authors.lastname: Hayashida
authors.forename: Kazuomi
authors.initials: K
authors.lastname: Kan
authors.forename: Takao
authors.initials: T
authors.lastname: Ichihara
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Aizawa
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Saito
authors.forename: Takashi
authors.initials: T
authors.lastname: Niju
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ikeda
authors.forename: Masato
authors.initials: M
authors.lastname: Sakon
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000556:secondary* / Q000628:therapy*; D016190:Carboplatin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy*; D008207:Lymphatic Metastasis / Q000473:pathology*; D008482:Mediastinum; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D017239:Paclitaxel / Q000008:administration & dosage; D016634:Radiosurgery
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D016190:Carboplatin; D017239:Paclitaxel