title: Correlation between WT1 expression and cell proliferation in endometrial cancer.
abstract: BACKGROUND
  The Wilms' tumor gene WT1 is overexpressed in endometrial cancer. Although recent studies have revealed that WT1 is a new prognostic factor, it remains unclear whether WT1 plays a pathophysiological role including cell proliferation.
  
  
  METHODS
  A series of 70 endometrial cancer patients who had undergone a curative resection was studied by immunohistochemistry to determine the correlation between WT1 expression and cell proliferation (proliferating cell nuclear antigen; PCNA).
  
  
  RESULTS
  WT1 expression was observed in 64 cases (91%). WT1 expression was associated with advanced FIGO stage (p=0.0228), myometrial invasion (p=0.0114) and high-grade histological differentiation (p=0.0004), indicating up-regulation of WT1 expression with tumor progression. A positive correlation between PCNA labeling index and score of WT1 expression was observed (p=0.0081, rho=0.319).
  
  
  CONCLUSIONS
  These results showed that WT1 might regulate cell proliferation in endometrial cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, Kanazawa, Ishikawa, 920-8641 Japan. satoshi-dohi@y6.dion.ne.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Dohi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohno
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Ohno
authors.forename: Gen-Ichiro
authors.initials: G
authors.lastname: Soma
authors.forename: Satoru
authors.initials: S
authors.lastname: Kyo
authors.forename: Masaki
authors.initials: M
authors.lastname: Inoue
mesh_terms: D000328:Adult; D000368:Aged; D048708:Cell Growth Processes / Q000502:physiology; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis; D025721:WT1 Proteins / Q000096:biosynthesis*
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D025721:WT1 Proteins