Analogues of distamycin--synthesis and biological evaluation of new aromatic oligopeptides, potential anticancer agents.
Six new aromatic oligopeptides were synthesized and evaluated for their activity in the standard cell line of the mammalian tumor MCF-7 as well as in a cell-free system employing the topoisomerase I/II inhibition assay.
Drozdowska
Danuta
D
Department of Organic Chemistry, Medical University, 2A Mickiewicza, 15-222 Białystok, Poland. Danuta.Drozdowska@umwb.edu.pl
Rusak
Małgorzata
M
Bielawski
Tomasz
T
Midura-Nowaczek
Krystyna
K
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004214:Distamycins / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D059003:Topoisomerase Inhibitors
D000970:Antineoplastic Agents; D004214:Distamycins; D059003:Topoisomerase Inhibitors