Psychiatric disorder in two siblings with hallervorden-spatz disease.
Hallervorden-Spatz disease (HSD) is a rare autosomal-recessive hereditary disorder characterized by the early onset of progressive movement alterations, including dystonia, rigidity, choreoathetosis, and mental deterioration. HSD is also associated with a variety of psychiatric symptoms, primarily depression and mental deterioration. However, psychosis has rarely been reported as a major symptom of HSD. We report two siblings who presented psychiatric symptoms as major clinical presentations, accompanied by ataxic and spastic gait, dysarthria, and typical neuroimaging findings of HSD. A 14-year-old girl presented complex motor tics, stereotypic behavior and anxiety symptoms. Her older brother, a 16-year-old boy, presented prominent auditory hallucinations, persecutory delusions and social withdrawal symptoms. Psychiatric symptoms were improved after atypical antipsychotic treatment. HSD is a rare disease but should be carefully considered in the diagnosis of patients with both motor disorder and various psychiatric symptoms.
Sunwoo
Young-Kyung
YK
Department of Psychiatry, Inha University College of Medicine, Incheon, Korea.
Lee
Jeong-Seop
JS
Kim
Won-Hyoung
WH
Shin
Yong-Bum
YB
Lee
Myung-Ji
MJ
Cho
In-Hee
IH
Ock
Sun-Myeong
SM