Construction of all-carbon quaternary center by R2AlCl-mediated ring-opening reaction of oxacycles.
An unexpected R(2)AlCl-mediated ring-opening reaction of oxacycles for the formation of all-carbon quaternary centers was discovered, and a possible mechanism is proposed. The developed chemistry provides a concise approach to synthesize structural diverse of dolastane-type compounds.
Che
Chao
C
Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
Liu
Lianzhu
L
Gong
Jianxian
J
Yang
Yunfang
Y
Wang
Guoxin
G
Quan
Junmin
J
Yang
Zhen
Z
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure
D004224:Diterpenes