title: Cytotoxic acylphloroglucinol derivatives from the twigs of Garcinia cowa.
abstract: An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B-D, 2-4) and nine known analogues, was isolated and characterized from the twigs of Garcinia cowa. The structures of 1-4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxicity against two cancer cell lines (HT-29 and HCT116) and against normal colon cells (CCD-18Co), and the results demonstrated their selective toxicity toward the cancer cells.
authors.affiliation: Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, Hong Kong, People's Republic of China.
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.forename: Winnie L T
authors.initials: WL
authors.lastname: Kan
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Jing-Zheng
authors.initials: JZ
authors.lastname: Song
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Qiao
authors.forename: Chi-Hin
authors.initials: CH
authors.lastname: Cho
authors.forename: John A
authors.initials: JA
authors.lastname: Rudd
authors.forename: Ge
authors.initials: G
authors.lastname: Lin
authors.forename: Hong-Xi
authors.initials: HX
authors.lastname: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D029760:Garcinia / Q000737:chemistry; D045325:HCT116 Cells; D019073:HT29 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D010696:Phloroglucinol