Brain amines and emotional stress.
Evidence is presented that emotional stress in the mouse, guinea pig, and rat are associated with 10-30 per cent decrements in brain norepinephrine. This does not appear to be primarily a function of muscular activity and is probably a neurochemical concomitant of the 'emotional' upset. It is a generalized phenomenon that occurs in cortex, subcortex, cerebellum, hypothalamus, and brain stem, to approximately the same degree. Under these circumstances the concentration in brain of serotonin, gamma-aminobutyric acid, and dopamine remain stable. It appears that decreases of brain norepinephrine may be a component of a general response to intense, emotional distress.
Bliss
E L
EL
Department of Psychiatry, University of Utah College of Medicine, Salt Lake City, Utah, USA.
Zwanziger
J
J
D000704:Analysis of Variance; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D004597:Electroshock / Q000009:adverse effects; D004644:Emotions / Q000502:physiology*; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical / Q000379:methods; D013315:Stress, Psychological / Q000473:pathology* / Q000503:physiopathology*
D001679:Biogenic Amines