title: Anti-angiogenic perfluorocarbon nanoparticles for diagnosis and treatment of atherosclerosis.
abstract: Complementary developments in nanotechnology, genomics, proteomics, molecular biology and imaging offer the potential for early, accurate diagnosis. Molecularly-targeted diagnostic imaging agents will allow noninvasive phenotypic characterization of pathologies and, therefore, tailored treatment close to the onset. For atherosclerosis, this includes anti-angiogenic therapy with specifically-targeted drug delivery systems to arrest the development of plaques before they impinge upon the lumen. Additionally, monitoring the application and effects of this targeted therapy in a serial fashion will be important. This review covers the specific application of alpha(nu)beta(3)-targeted anti-angiogenic perfluorocarbon nanoparticles in (1) the detection of molecular markers for atherosclerosis, (2) the immediate verification of drug delivery with image-based prediction of therapy outcomes, and (3) the serial, noninvasive observation of therapeutic efficacy.
authors.affiliation: Washington University School of Medicine and Philips Medical Systems, St. Louis, MO, USA. SCaruthers@cmrl.wustl.edu
authors.forename: Shelton D
authors.initials: SD
authors.lastname: Caruthers
authors.forename: Tillmann
authors.initials: T
authors.lastname: Cyrus
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Winter
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Wickline
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Lanza
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage* / Q000737:chemistry; D000818:Animals; D050197:Atherosclerosis / Q000175:diagnosis* / Q000188:drug therapy*; D003952:Diagnostic Imaging / Q000379:methods*; D004337:Drug Carriers / Q000737:chemistry*; D005466:Fluorocarbons / Q000737:chemistry*; D006801:Humans; D015336:Molecular Probe Techniques; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D020533:Angiogenesis Inhibitors; D004337:Drug Carriers; D005466:Fluorocarbons