Role of endogenous testosterone concentration in pediatric stroke.
Previous studies have indicated a male predominance in pediatric stroke. To elucidate this gender disparity, total testosterone concentration was measured in children with arterial ischemic stroke (AIS; n = 72), children with cerebral sinovenous thrombosis (CSVT; n = 52), and 109 healthy controls. Testosterone levels above the 90th percentile for age and gender were documented in 10 children with AIS (13.9%) and 10 with CSVT (19.2%), totaling 16.7% of patients with cerebral thromboembolism overall, as compared with only 2 of 109 controls (1.8%; p = 0.002). In multivariate analysis with adjustment for total cholesterol level, hematocrit, and pubertal status, elevated testosterone was independently associated with increased disease risk (odds ratio [95% confidence interval]: overall = 3.98 [1.38-11.45]; AIS = 3.88 [1.13-13.35]; CSVT = 5.50 [1.65-18.32]). Further adjusted analyses revealed that, for each 1nmol/l increase in testosterone in boys, the odds of cerebral thromboembolism were increased 1.3-fold.
Normann
Sandra
S
Department of Pediatric Hematology, University Children's Hospital, University of Münster, Münster, Germany.
de Veber
Gabrielle
G
Fobker
Manfred
M
Langer
Claus
C
Kenet
Gili
G
Bernard
Timothy J
TJ
Fiedler
Barbara
B
Sträter
Ronald
R
Goldenberg
Neil A
NA
Nowak-Göttl
Ulrike
U
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006400:Hematocrit / Q000379:methods; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D010372:Pediatrics; D012189:Retrospective Studies; D012737:Sex Factors; D012851:Sinus Thrombosis, Intracranial / Q000097:blood*; D020521:Stroke / Q000097:blood*; D013739:Testosterone / Q000097:blood*
D013739:Testosterone; D002784:Cholesterol