The many roles of microRNAs in brain tumor biology.
MicroRNAs (miRNAs) are now recognized as the primary RNAs involved in the purposeful silencing of the cell's own message. In addition to the established role of miRNAs as developmental regulators of normal cellular function, they have recently been shown to be important players in pathological states such as cancer. The authors review the literature on the role of miRNAs in the formation and propagation of gliomas and medulloblastomas, highlighting the potential of these molecules and their inhibitors as therapeutics.
Turner
Jay D
JD
Division of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona, USA.
Williamson
Richard
R
Almefty
Kaith K
KK
Nakaji
Peter
P
Porter
Randall
R
Tse
Victor
V
Kalani
M Yashar S
MY
D014408:Biomarkers, Tumor / Q000235:genetics; D001932:Brain Neoplasms / Q000235:genetics* / Q000503:physiopathology* / Q000628:therapy; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing / Q000502:physiology; D005910:Glioma / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D008527:Medulloblastoma / Q000235:genetics / Q000503:physiopathology; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D055495:Neurogenesis / Q000235:genetics / Q000502:physiology
D014408:Biomarkers, Tumor; D035683:MicroRNAs