Catalytic alkylation of methyl-N-heteroaromatics with alcohols.
A novel catalytic C-C coupling reaction in which N-heteroaromatic-substituted methyl groups are efficiently alkylated using primary alcohols is introduced. The synthesis protocol is based on iridium catalysts and most likely relies on the "borrowing hydrogen" or "hydrogen autotransfer" mechanism. A variety of substrate combinations can readily be employed in this reaction, including pyrimidines, pyrazines, pyridazines, and even fairly activated 2- and 4-picolines.
Blank
Benoît
B
Anorganische Chemie II, Universität Bayreuth, 95440 Bayreuth, Germany.
Kempe
Rhett
R
D000438:Alcohols / Q000737:chemistry*; D000478:Alkylation; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000438:Alcohols; D006571:Heterocyclic Compounds; D006841:Hydrocarbons, Aromatic; D009942:Organometallic Compounds; D007495:Iridium