Experimental approaches to the study of epigenomic dysregulation in ageing.
In this review, we describe how normal ageing may involve the acquisition of epigenetic errors over time, akin to the accumulation of genetic mutations with ageing. We describe how such experiments are currently performed, their limitations technically and analytically and their application to ageing research.
Thompson
Reid F
RF
Department of Genetics and Center for Epigenomics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Fazzari
Melissa J
MJ
Greally
John M
JM
D000375:Aging / Q000235:genetics* / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D019175:DNA Methylation / Q000235:genetics / Q000502:physiology; D044127:Epigenesis, Genetic / Q000235:genetics* / Q000502:physiology; D006657:Histones / Q000235:genetics / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*
D006657:Histones