Enantioseparation of benzazoles and benzanilides on polysaccharide-based chiral columns.
The chiral recognition ability of the polysaccharide-based chiral columns (Chiralpak AD-RH, Chiralpak AS-RJ, Chiralpak IC, Chiralcel OD-RH, and Chiralcel OJ-RH) for the benzazoles and the benzanilides was evaluated under reversed phase conditions. The columns showed the high chiral recognition ability for a wide range of benzazoles and benzanilides. Twenty-one racemates were used for the evaluation, and 20 racemates were completely separated on at least one of the columns. In particular, AS-RH and OJ-RH showed the high chiral recognition ability for the benzazoles, and the AD-RH, IC, and OJ-RH were effective for the benzanilides.
Kubota
Takateru
T
Department of Process Research, Merck Research Laboratories, Merck & Co., Inc, Tsukuba, Ibaraki 300-2611, Japan. Takateru_kubota@merck.com
Sawada
Naotaka
N
Zhou
Lili
L
Welch
Christopher J
CJ
D000688:Amylose / Q000031:analogs & derivatives / Q000737:chemistry; D000813:Anilides / Q000737:chemistry*; D001565:Benzoates / Q000737:chemistry; D002219:Carbamates / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D002623:Chemistry Techniques, Analytical / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002852:Chromatography, Ion Exchange / Q000295:instrumentation* / Q000379:methods; D007211:Indoles / Q000737:chemistry*; D008956:Models, Chemical; D048448:Phenylcarbamates / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*; D013237:Stereoisomerism
D000813:Anilides; D001565:Benzoates; D002219:Carbamates; D007211:Indoles; D048448:Phenylcarbamates; D011134:Polysaccharides; C445088:chiralpak AS; C090722:tris(4-methylbenzoate)cellulose; C065943:cellulose tris-3,5-dimethylphenyl-carbamate; C080033:Chiralpak AD; C030374:indole; D002482:Cellulose; D000688:Amylose; C034595:benzanilide