title: Defining juxtapapillary diverticulum with 3D segmented trueFISP MRCP: comparison with conventional MRCP sequences with an oral negative contrast agent.
abstract: OBJECTIVE
  To compare three-dimensional segmented true fast imaging with steady-state precession magnetic resonance cholangiopancreatography (3D-trueFISP-MRCP) to conventional MRCP sequences with an oral negative contrast agent for diagnosing juxtapapillary diverticulum.
  
  
  METHODS
  A total of 42 patients with (n = 21) and without (n = 21) juxtapapillary diverticulum confirmed by endoscopic retrograde cholangiopancreatography (ERCP) were evaluated. Three MRCP sequences, 3D-trueFISP-MRCP, two-dimensional rapid acquisition with relaxation enhancement MRCP (2D-RARE-MRCP), and 3D T(2)-weighted turbo spin-echo MRCP (3D-TSE-MRCP), obtained after administering an oral negative contrast agent (FerriSeltz; Otsuka Pharmaceutical, Tokushima, Japan) were compared. Two radiologists independently and blindly interpreted the presence or absence of juxtapapillary diverticulum and its positional relationship against the papilla. The detectability of juxtapapillary diverticulum of each sequence as decided by consensus was then compared. Kappa statistics were used to measure interobserver agreement of the classifications.
  
  
  RESULTS
  The sensitivity, specificity, and accuracy for detecting juxtapapillary diverticulum of 3D-trueFISPMRCP (61.9%, 85.7%, and 73.8%) were substantively higher than those of 2D-RARE-MRCP (0.0%, 100%, and 50.0%) and 3D-TSE-MRCP (9.5%, 100%, and 54.8%). Interobserver agreement of the position of juxtapapillary diverticulum by 3D-trueFISP-MRCP was good (kappa = 0.55).
  
  
  CONCLUSIONS
  3D-trueFISP-MRCP can define juxtapapillary diverticulum even with an oral negative contrast agent, whereas conventional MRCP sequences cannot.
authors.affiliation: Department of Radiology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan. i@imodey.com
authors.forename: Satoru
authors.initials: S
authors.lastname: Morita
authors.forename: Eiko
authors.initials: E
authors.lastname: Ueno
authors.forename: Ai
authors.initials: A
authors.lastname: Masukawa
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Suzuki
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Machida
authors.forename: Mikihiko
authors.initials: M
authors.lastname: Fujimura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater; D049448:Cholangiopancreatography, Magnetic Resonance / Q000379:methods*; D003287:Contrast Media; D004240:Diverticulum / Q000473:pathology*; D004378:Duodenal Diseases / Q000473:pathology*; D005260:Female; D005290:Ferric Compounds; D006801:Humans; D007089:Image Enhancement; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D000644:Quaternary Ammonium Compounds; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D000644:Quaternary Ammonium Compounds; C013531:ferric ammonium citrate