title: Brain serotonin-2 receptors in acute mania.
abstract: BACKGROUND
  Although 5-hydroxytryptamine (5-HT) has been implicated in mania, the precise alterations in the 5-HT system remain elusive.
  
  
  OBJECTIVE
  To assess brain 5-HT2 receptors in drug-free individuals experiencing a manic episode in comparison with healthy volunteers using positron emission tomography (PET).
  
  
  METHODS
  Participants (n = 10) with DSM-IV bipolar I disorder-manic episode and healthy controls (n = 10) underwent [18F]-setoperone scans. The differences in 5-HT2 receptor binding potential between the two groups were determined using statistical parametric mapping (SPM) analysis.
  
  
  RESULTS
  Age was a significant correlate with 5-HT2 receptor binding potential with a similar magnitude of correlation in both groups. The SPM analysis with age as a covariate showed that the individuals with current mania had significantly lower 5-HT2 receptor binding potential in frontal, temporal, parietal and occipital cortical regions, with changes more prominent in the right cortical regions compared with controls.
  
  
  CONCLUSIONS
  This study suggests that brain 5-HT2 receptors are decreased in people with acute mania.
authors.affiliation: Mood Disorders Program, University of British Columbia, Vancouver, Canada. yatham@exchange.ubc.ca
authors.forename: Lakshmi N
authors.initials: LN
authors.lastname: Yatham
authors.forename: Peter F
authors.initials: PF
authors.lastname: Liddle
authors.forename: Jonathan
authors.initials: J
authors.lastname: Erez
authors.forename: Marcia
authors.initials: M
authors.lastname: Kauer-Sant'Anna
authors.forename: Raymond W
authors.initials: RW
authors.lastname: Lam
authors.forename: Miguel
authors.initials: M
authors.lastname: Imperial
authors.forename: Vesna
authors.initials: V
authors.lastname: Sossi
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Ruth
mesh_terms: D000328:Adult; D000367:Age Factors; D001714:Bipolar Disorder / Q000000981:diagnostic imaging / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D001931:Brain Mapping; D016022:Case-Control Studies; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D044348:Receptors, Serotonin, 5-HT2 / Q000378:metabolism*; D055815:Young Adult
chemical_list: D044348:Receptors, Serotonin, 5-HT2