NRG1 and BDNF genes in schizophrenia: an association study in an Italian case-control sample.
We tested for associations between five single nucleotide polymorphisms (SNPs) located in the area containing the Neuregulin 1 gene (NRG1) and three SNPs within the brain-derived neutrophic factor gene (BDNF) in an Italian sample consisting of 171 schizophrenia subjects and 349 controls. No association was found for any of the polymorphisms tested, either in single locus or in haplotype analysis.
Squassina
Alessio
A
Laboratory of Molecular Genetics, Section of Clinical Pharmacology, Department of Neurosciences B.B. Brodie, University of Cagliari, 09042 Monserrato, Cagliari, Italy.
Piccardi
Paola
P
Del Zompo
Maria
M
Rossi
Alessandro
A
Vita
Antonio
A
Pini
Stefano
S
Mucci
Armida
A
Galderisi
Silvana
S
D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D020890:Neuregulin-1 / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
D019208:Brain-Derived Neurotrophic Factor; D020890:Neuregulin-1