title: An evidence for adhesion-mediated acquisition of acute myeloid leukemic stem cell-like immaturities.
abstract: For long-term survival in vitro and in vivo of acute myeloid leukemia cells, their adhesion to bone marrow stromal cells is indispensable. However, it is still unknown if these events are uniquely induced by the leukemic stem cells. Here we show that TF-1 human leukemia cells, once they have formed a cobblestone area by adhering to mouse bone marrow-derived MS-5 cells, can acquire some leukemic stem cell like properties in association with a change in the CD44 isoform-expression pattern and with an increase in a set of related microRNAs. These findings strongly suggest that at least some leukemia cells can acquire leukemic stem cell like properties in an adhesion-mediated stochastic fashion.
authors.affiliation: Department of Integrative Bioscience and Biomedical Engineering, Waseda University, Shinjuku-ku, Tokyo 169-8555, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Funayama
authors.forename: Miyuki
authors.initials: M
authors.lastname: Shimane
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nomura
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Asano
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000473:pathology; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D002470:Cell Survival; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D035683:MicroRNAs / Q000235:genetics; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology
chemical_list: D018960:Hyaluronan Receptors; D035683:MicroRNAs