title: Ruthenium catalyzed directing group-free C2-selective carbenoid functionalization of indoles by alpha-aryldiazoesters.
abstract: A directing group-free approach for C2-selective carbenoid functionalization of NH-indoles is presented. Using [RuCl(2)(p-cymene)](2) as catalyst and alpha-aryldiazoesters as carbenoid source, 2-alkylated indoles were obtained in up to 96% isolated yield. Similarly, a regioselective carbenoid functionalization of NH-pyrroles was also achieved.
authors.affiliation: Open Laboratory of Chirotechnology, The Institute of Molecular Technology for Drug Discovery and Synthesis and the Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
authors.forename: Wai-Wing
authors.initials: WW
authors.lastname: Chan
authors.forename: Shing-Hin
authors.initials: SH
authors.lastname: Yeung
authors.forename: Zhongyuan
authors.initials: Z
authors.lastname: Zhou
authors.forename: Albert S C
authors.initials: AS
authors.lastname: Chan
authors.forename: Wing-Yiu
authors.initials: WY
authors.lastname: Yu
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D012428:Ruthenium