title: A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration.
abstract: Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the dysfunction of GABAergic interneurons that normally regulate prefrontal information processing. Here, we studied a subclass of interneurons isolated in rat OFC using extracellular waveform and spike train analysis. During performance of a goal-directed behavioral task, the firing of this class of putative fast-spiking (FS) interneurons showed robust temporal correlations indicative of a functionally coherent network. FS cell activity also co-varied with behavioral response latency, a key indicator of motivational state. Systemic administration of ketamine, a drug that can mimic psychosis, preferentially inhibited this cell class. Together, these results support the idea that OFC-FS interneurons form a critical link in the regulation of motivation by prefrontal circuits during normal and abnormal brain and behavioral states.
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor NY, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Quirk
authors.forename: Dara L
authors.initials: DL
authors.lastname: Sosulski
authors.forename: Claudia E
authors.initials: CE
authors.lastname: Feierstein
authors.forename: Naoshige
authors.initials: N
authors.lastname: Uchida
authors.forename: Zachary F
authors.initials: ZF
authors.lastname: Mainen