title: Antibiotic regimen including linezolid for treating prosthetic valve endocarditis with cerebral embolism due to methicillin-susceptible Staphylococcus aureus after failure with oxacillin and teicoplanin.
abstract: A case of prosthetic valve endocarditis due to methicillin susceptible Staphylococcus aureus (MSSA) with cerebral metastatic seeding is described. The patient is a 61 year old man with diabetes mellitus, chronic renal failure and previous bacterial endocarditis. Despite appropriate MSSA therapy, the patient was eventually cured with the introduction of linezolid, without needing surgical intervention.
authors.affiliation: Department of Cardiology, Civil Hospital, Venice, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Brugraro
authors.forename: F
authors.initials: F
authors.lastname: Eseme
authors.forename: E
authors.initials: E
authors.lastname: Morelli
authors.forename: M
authors.initials: M
authors.lastname: Fiscon
authors.forename: G
authors.initials: G
authors.lastname: Rosini
authors.forename: F
authors.initials: F
authors.lastname: Belussi
authors.forename: F
authors.initials: F
authors.lastname: Ebo
authors.forename: A
authors.initials: A
authors.lastname: Petrucci
authors.forename: P
authors.initials: P
authors.lastname: Tenderini
authors.forename: E
authors.initials: E
authors.lastname: Raise
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001021:Aortic Valve / Q000601:surgery*; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000209:etiology*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D020766:Intracranial Embolism / Q000188:drug therapy*; D000069349:Linezolid; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D010068:Oxacillin / Q000627:therapeutic use*; D023303:Oxazolidinones / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D017334:Teicoplanin / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D017334:Teicoplanin; D000069349:Linezolid; D010068:Oxacillin