title: Extracellular matrix molecules: endogenous danger signals as new drug targets in kidney diseases.
abstract: Extracellular matrix (ECM) components, commonly thought to function purely as structural elements are now demonstrated to act as signaling molecules. With the identification of matrix-derived endogenous ligands of Toll-like and NOD-like receptors of innate immunity, a general question about the mechanisms of soluble ECM components signaling as autonomous triggers of sterile or enhancers of pathogen-mediated inflammation gained notable relevance. They act as fundamental danger signals signifying tissue injury by eliciting a robust proinflammatory response. Immense therapeutic potential resides in translating this knowledge into the development of Toll-like and NOD-like receptor inhibitors. This review focuses on the role of ECM-derived ligands of innate immunity receptors as mediators of renal inflammation and promising pharmacological targets in kidney disease.
authors.affiliation: Pharmazentrum Frankfurt, Institut für Allgemeine Pharmakologie und Toxikologie/ZAFES, Klinikum der JW Goethe-Universität Frankfurt am Main, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. Schaefer@med.uni-frankfurt.de
authors.forename: Liliana
authors.initials: L
authors.lastname: Schaefer
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000378:metabolism; D007674:Kidney Diseases / Q000188:drug therapy* / Q000378:metabolism; D009393:Nephritis / Q000188:drug therapy* / Q000378:metabolism; D053472:Nod Signaling Adaptor Proteins / Q000187:drug effects / Q000378:metabolism; D011509:Proteoglycans / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000187:drug effects / Q000378:metabolism
chemical_list: D016326:Extracellular Matrix Proteins; D018836:Inflammation Mediators; D053472:Nod Signaling Adaptor Proteins; D011509:Proteoglycans; D051193:Toll-Like Receptors