title: Frequency of distinguishing clinical features in Vogt-Koyanagi-Harada disease.
abstract: OBJECTIVE
  To determine the frequency of occurrence of limited clinical features which distinguish patients with Vogt-Koyanagi-Harada (VKH) disease from those with non-VKH uveitis.
  
  
  METHODS
  Comparative case series.
  
  
  METHODS
  We included 1147 patients.
  
  
  METHODS
  All patients with bilateral ocular inflammatory disease presenting to any of 10 uveitis centers in the 3-month period between January 1 and March 31, 2006 (inclusive), were asked to participate. The clinical and historical features of disease were obtained from the participants via direct interview and chart review. Patients were stratified based on whether they were diagnosed with VKH disease or non-VKH uveitis for statistical analysis.
  
  
  METHODS
  Presence or absence of various clinical features in the 2 populations.
  
  
  RESULTS
  Of 1147 patients, 180 were diagnosed with VKH disease and 967 with non-VKH uveitis. Hispanics and Asians were more likely to be diagnosed with VKH than non-VKH disease compared with other ethnicities. In acute disease, the finding of exudative retinal detachment was most likely to be found in VKH disease with a positive predictive value (PPV) of 100 and negative predictive value (NPV) of 88.4, whereas in chronic disease, sunset glow fundus was most likely to be found, with a PPV of 94.5 and NPV of 89.2.
  
  
  CONCLUSIONS
  Numerous clinical findings have been described in the past as important in the diagnosis of VKH. The current study reveals that of these, 2 are highly specific to this entity in an ethnically and geographically diverse group of patients with nontraumatic bilateral uveitis. These clinical findings are exudative retinal detachment during acute disease and sunset glow fundus during the chronic phase of the disease.
authors.affiliation: Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine of University of Southern California, Los Angeles, California 90033, USA. nrao@usc.edu
authors.forename: Narsing A
authors.initials: NA
authors.lastname: Rao
authors.forename: Amod
authors.initials: A
authors.lastname: Gupta
authors.forename: Laurie
authors.initials: L
authors.lastname: Dustin
authors.forename: Soon Phaik
authors.initials: SP
authors.lastname: Chee
authors.forename: Annabelle A
authors.initials: AA
authors.lastname: Okada
authors.forename: Moncef
authors.initials: M
authors.lastname: Khairallah
authors.forename: Bahram
authors.initials: B
authors.lastname: Bodaghi
authors.forename: Phuc
authors.initials: P
authors.lastname: Lehoang
authors.forename: Massimo
authors.initials: M
authors.lastname: Accorinti
authors.forename: Manabu
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Tisha
authors.initials: T
authors.lastname: Prabriputaloong
authors.forename: Russell W
authors.initials: RW
authors.lastname: Read
mesh_terms: D000208:Acute Disease; D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D014605:Uveitis / Q000175:diagnosis; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis*