Synthesis and characterization of thermo-sensitive semi-IPN hydrogels based on poly(ethylene glycol)-co-poly(epsilon-caprolactone) macromer, N-isopropylacrylamide, and sodium alginate.
Thermo-sensitive semi-IPN hydrogels were prepared via in situ copolymerization of N-isopropylacrylamide (NIPAAm) with poly(ethylene glycol)-co-poly(epsilon-caprolactone) (PEG-co-PCL) macromer in the presence of sodium alginate by UV irradiation technology. The effects of the sodium alginate content, temperature, and salt on the swelling behavior of the as-obtained hydrogels were studied. The results showed that the swelling ratio of the hydrogels increased with the increasing sodium alginate content at the same temperature, and decreased with the increase in temperature. The salt sensitivity of the semi-IPN hydrogels was dependent on the content of sodium alginate introduced in the hydrogels. The mechanical rheology of the hydrogels and in vitro release behavior of bovine serum albumin (BSA) in situ encapsulated within the hydrogels were also investigated. It was found that the introduction of sodium alginate with semi-IPN structure improved mechanical strength of the hydrogels and the cumulative release percentage of BSA from the hydrogels. Such double-sensitive semi-IPN hydrogel materials could be exploited as potential candidates for drug delivery carriers.
Zhao
Sanping
S
Key Laboratory of Green Processing and Functional Textiles of New Textile Materials of Ministry of Education, Wuhan University of Science and Engineering, Wuhan 430073, PR China. zhaosanping@163.com
Cao
Mengjie
M
Li
Han
H
Li
Liyan
L
Xu
Weilin
W
D000178:Acrylamides / Q000737:chemistry; D000464:Alginates / Q000737:chemistry; D055598:Chemical Phenomena; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis*; D005027:Ethylene Oxide / Q000737:chemistry / Q000528:radiation effects; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects; D007700:Kinetics; D007783:Lactones / Q000737:chemistry / Q000528:radiation effects; D012212:Rheology; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014466:Ultraviolet Rays
D000178:Acrylamides; D000464:Alginates; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D006603:Hexuronic Acids; D020100:Hydrogels; D007783:Lactones; C400421:PLC(20)-b-PEO(44); D020723:Glucuronic Acid; C067295:N-isopropylacrylamide; D005027:Ethylene Oxide