title: Autophagy regulation by p53.
abstract: Autophagy is an evolutionarily conserved catabolic pathway that is involved in numerous physiological processes and in multiple pathological conditions including cancer. Autophagy is regulated by an intricate network of signaling cascades that have not yet been entirely disentangled. Accumulating evidence indicates that p53, the best-characterized human tumor suppressor protein, can modulate autophagy in a dual fashion, depending on its subcellular localization. On the one hand, p53 functions as a nuclear transcription factor and transactivates proapoptotic, cell cycle-arresting and proautophagic genes. On the other hand, cytoplasmic p53 can operate at mitochondria to promote cell death and can repress autophagy via poorly characterized mechanisms. This review focuses on the recently discovered function of p53 as a master regulator of autophagy.
authors.affiliation: INSERM, U848, F-94805 Villejuif, France.
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Maiuri
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Galluzzi
authors.forename: Eugenia
authors.initials: E
authors.lastname: Morselli
authors.forename: Oliver
authors.initials: O
authors.lastname: Kepp
authors.forename: Shoaib Ahmad
authors.initials: SA
authors.lastname: Malik
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
mesh_terms: D000818:Animals; D001343:Autophagy; D006801:Humans; D008954:Models, Biological; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53