Immunohistochemistry of DNA mismatch repair enzyme MSH2 is not correlated with prognostic data from endometrial carcinomas.
BACKGROUND
The human Mut-S-homolog-2 (MSH2) is part of the DNA mismatch repair system (MMR). Mutations in genes of the MMR are a predisposition to hereditary non-polyposis colorectal cancer (HNPCC). In women, MMR gene mutations may lead to primary endometrial cancer (EC). The important function of the MMR for the integrity of the DNA during replication makes it probable that the MMR might also be involved in the development and the course of sporadic carcinomas. Insufficient MMR activity or expression levels could be prognostic markers of the disease.


METHODS
Immunohistochemical analysis of MSH2 was performed in 86 tumor samples from patients with EC.


RESULTS
Compared to known tumor markers, namely estrogen and progesterone receptors, histopathological grading, TNM stage and FIGO classification, no significant correlation between MSH2 immunoreactivity and EC was found.


CONCLUSIONS
MSH2 immunohistochemical analysis is not of prognostic value for endometrial carcinoma.
Schröer
Andreas
A
Department of Gynecology and Obstetrics, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany.
Köster
Frank
F
Fischer
Dorothea
D
Dubitscher
Ralph Martin
RM
Woll-Hermann
Astrid
A
Diedrich
Klaus
K
Friedrich
Michael
M
Salehin
Darius
D
D017209:Apoptosis / Q000502:physiology; D053843:DNA Mismatch Repair; D016889:Endometrial Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis; D051718:MutS Homolog 2 Protein / Q000096:biosynthesis*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
D019394:Ki-67 Antigen; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein