Techniques to assess film coatings and evaluate film-coated products.
BACKGROUND
Polymeric film coatings have been applied to pharmaceutical solids for decorative, protective, or functional purposes. The application process is quite complex, with variables related to the coating formulation, substrate properties, processing parameters, and interactions thereof, all of which can affect product performance.


OBJECTIVE
This article describes a number of experimental techniques used to determine the physical, mechanical, adhesive, thermal, and permeability properties of free and applied films. These analytical tools can be used to optimize product performance, advance our knowledge of the film formation process, and investigate interactions between the coating and the solid surface.


CONCLUSIONS
Through a better understanding of film-coating processes, the cause of problems that arise during manufacturing, defects observed in the coating, and changes in performance upon subsequent storage may be more quickly and accurately resolved.
Porter
Stuart C
SC
International Specialty Products, Wayne, NJ, USA.
Felton
Linda A
LA
D002626:Chemistry, Pharmaceutical; D019245:Compressive Strength; D004339:Drug Compounding; D005079:Excipients; D008422:Materials Testing / Q000379:methods*; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties; D013607:Tablets / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013718:Tensile Strength
D005079:Excipients; D004364:Pharmaceutical Preparations; D013607:Tablets