title: The biocompatability of mesoporous inorganic-organic hybrid resin films with ionic and hydrophilic characteristics.
abstract: New mesoporous silicate-titania resin systems hybridized with 4,5-dihydroxy-m-benzenedisulfonic acid and poly(ethylene glycol)-dimethacrylate component were developed. These inorganic-organic hybrid resins were found to reveal highly controlled ionic and hydrophilic surface with excellent durability and adhesion onto various substrates. The resin films revealed high resistance to nonspecific adsorption of fibrinogen and to adherence by several bacterial pathogens such as Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis. Furthermore, excellent biocompatibility of the developed resins was proved by both HEp-2 cell adhesion in vitro and subcutaneous implantation in mice. The inorganic-organic hybrid resins are strongly promising for biomedical applications including biomedical devices and biosensors.
authors.affiliation: Department of Chemistry, National Research Lab for Polymer Synthesis and Physics, Center for Electro-Photo Behaviors in Advanced Molecular Systems, Division of Advanced Materials Science, Pohang Accelerator Laboratory, BK School of Molecular Science, and Polymer Research Institute, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
authors.forename: Gahee
authors.initials: G
authors.lastname: Kim
authors.forename: Lan Young
authors.initials: LY
authors.lastname: Hong
authors.forename: Jungwoon
authors.initials: J
authors.lastname: Jung
authors.forename: Dong-Pyo
authors.initials: DP
authors.lastname: Kim
authors.forename: Heesoo
authors.initials: H
authors.lastname: Kim
authors.forename: Ik Jung
authors.initials: IJ
authors.lastname: Kim
authors.forename: Jung Ran
authors.initials: JR
authors.lastname: Kim
authors.forename: Moonhor
authors.initials: M
authors.lastname: Ree
mesh_terms: D000818:Animals; D001419:Bacteria / Q000166:cytology / Q000187:drug effects; D001422:Bacterial Adhesion / Q000187:drug effects; D001557:Benzenesulfonates / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D007477:Ions; D008422:Materials Testing / Q000379:methods*; D008689:Methacrylates / Q000494:pharmacology*; D051379:Mice; D046529:Microscopy, Electron, Transmission; D011092:Polyethylene Glycols / Q000494:pharmacology*; D016062:Porosity / Q000187:drug effects; D012117:Resins, Synthetic / Q000494:pharmacology*; D053838:Scattering, Small Angle; D014961:X-Ray Diffraction
chemical_list: D001557:Benzenesulfonates; D001672:Biocompatible Materials; D007477:Ions; D008689:Methacrylates; D012117:Resins, Synthetic; C421283:poly(ethylene glycol)-dimethacrylate; D011092:Polyethylene Glycols