title: Adamantyl-functionalized polymer monolith for capillary electrochromatography.
abstract: An adamantyl (ADM)-functionalized monolithic stationary phase was newly synthesized by a single-step copolymerization of 1-adamantyl-(alpha-trifluoromethyl) acrylate, ethylene dimethacrylate, and 2-acrylamido-2-methyl-1-propanesulfonic acid in order to prevent the peak tailing of basic solutes in capillary electrochromatography and was compared with butyl methacrylate (BMA)-based one. The ADM structure shields the negatively charged groups on the surface of monolith from basic solutes, resulting in better peak shapes than BMA-based monolithic stationary phase. As the monomers ratio decreased, the monolithic column had lower retention and higher column efficiency which was likely due to lower phase ratio and smaller globule size of monolith, respectively. The ADM-functionalized monolithic columns exhibited a good repeatability and reproducibility of column preparation with relative standard deviation values below 9% in the studied chromatographic parameters.
authors.affiliation: Department of Environmental and Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521, Japan. k-ohyama@nagasaki-u.ac.jp
authors.forename: Kaname
authors.initials: K
authors.lastname: Ohyama
authors.forename: Yuki
authors.initials: Y
authors.lastname: Fukahori
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Nakashima
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Sueyoshi
authors.forename: Naoya
authors.initials: N
authors.lastname: Kishikawa
authors.forename: Naotaka
authors.initials: N
authors.lastname: Kuroda
mesh_terms: D000218:Adamantane / Q000737:chemistry*; D002021:Buffers; D053801:Capillary Electrochromatography / Q000295:instrumentation* / Q000379:methods; D006841:Hydrocarbons, Aromatic / Q000302:isolation & purification; D008689:Methacrylates / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D015203:Reproducibility of Results
chemical_list: D002021:Buffers; D006841:Hydrocarbons, Aromatic; D008689:Methacrylates; D011108:Polymers; D000218:Adamantane; C016284:butyl methacrylate