[From the ancient serotherapy to naked antibodies: a century of successful targeted therapies].
Monoclonal antibodies and molecular engineering have renewed the ancient serotherapy, multiplying the possibilities of therapeutic interventions and providing many new clinical successes! Standing back about this history allows us to better understand the evolution of concepts underlying the therapeutic use of antibodies, as well as the maturation of the tool itself. The different principles of therapeutic targeting will be successively tackled, from their sometimes hundred year-old conception until the most recent clinical developments: antibodies neutralizing toxins and soluble antigens, anti-microbial antibodies, cytotoxic antibodies, tumour-specific antibodies, cell function -modifying antibodies, etc. This overview will finally offer the opportunity to introduce a new pharmacological classification of the entire class of unconjugated -therapeutic antibodies.
Watier
Hervé
H
Université François Rabelais de Tours, Laboratoire d'immunologie, Faculté de médecine, 10, boulevard Tonnellé, 37032 Tours Cedex, France. watier@med.univ-tours.fr
D000047:Academies and Institutes / Q000266:history; D000818:Animals; D000906:Antibodies / Q000266:history* / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000145:classification / Q000266:history / Q000627:therapeutic use; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001424:Bacterial Infections / Q000276:immunology / Q000628:therapy; D004166:Diphtheria Antitoxin / Q000266:history / Q000627:therapeutic use; D016503:Drug Delivery Systems; D005060:Europe; D005602:France; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006736:Horses; D006801:Humans; D007116:Immunization, Passive / Q000266:history*; D007128:Immunoglobulin Fragments / Q000627:therapeutic use; D051379:Mice; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D011994:Recombinant Proteins / Q000627:therapeutic use; D009626:Terminology as Topic; D014481:United States; D014777:Virus Diseases / Q000276:immunology / Q000628:therapy
D000906:Antibodies; D000911:Antibodies, Monoclonal; D000961:Antilymphocyte Serum; D004166:Diphtheria Antitoxin; D007128:Immunoglobulin Fragments; D011994:Recombinant Proteins