title: Identification of a 0.4 Kb deletion region in 10q26 associated with endometrial carcinoma.
abstract: We have identified an allelic deletion common region in the q26 region of chromosome 10 in endometrial carcinomas, which has been reported previously as a potential target of genetic alterations related to this neoplasia. An allelotyping analysis of 19 pairs of tumoral and non-tumoral samples was accomplished using seven microsatellite polymorphic markers mapping in the 10q26 chromosomal region. Loss of heterozygosity for one or more loci was detected in 29% of the endometrial carcinoma samples. The observed pattern of loss enabled the identification of a 3.5 Mb common deleted region located between the D10S587 and D10S186 markers. An additional result from an endometrial sample with evidence of a RER phenotype may suggest a more centromeric region of loss within the above-mentioned interval. This 401.84 Kb interval flanked by the D10S587 and D10S216 markers may be a plausible location for a putative suppressor gene involved in early stage endometrial carcinogenesis.
authors.affiliation: Faculdade de Farmácia Universidade de Lisboa, Lisboa, Portugal.
authors.forename: Margarida
authors.initials: M
authors.lastname: Alves
authors.forename: Isabel
authors.initials: I
authors.lastname: Carreira
authors.forename: Paulo
authors.initials: P
authors.lastname: Liberato
authors.forename: Sância
authors.initials: S
authors.lastname: Ramos
authors.forename: Manuela
authors.initials: M
authors.lastname: Mafra
authors.forename: Alexandra S
authors.initials: AS
authors.lastname: Inverno
authors.forename: Ana T
authors.initials: AT
authors.lastname: Maia
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Martins
authors.forename: Miguel
authors.initials: M
authors.lastname: Brito
authors.forename: Carolino
authors.initials: C
authors.lastname: Monteiro
mesh_terms: D002277:Carcinoma / Q000235:genetics* / Q000473:pathology; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10 / Q000737:chemistry / Q000235:genetics; D004252:DNA Mutational Analysis; D004261:DNA Replication / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D019656:Loss of Heterozygosity; D016555:Matched-Pair Analysis; D053842:Microsatellite Instability