title: Patient-specific internal radionuclide dosimetry.
abstract: The development of patient-specific treatment planning systems is of outmost importance in the development of radionuclide dosimetry, taking into account that quantitative three-dimensional nuclear medical imaging can be used in this regard. At present, the established method for dosimetry is based on the measurement of the biokinetics by serial gamma-camera scans, followed by calculations of the administered activity and the residence times, resulting in the radiation-absorbed doses of critical organs. However, the quantification of the activity in different organs from planar data is hampered by inaccurate attenuation and scatter correction as well as because of background and organ overlay. In contrast, dosimetry based on quantitative three-dimensional data can be more accurate and allows an individualized approach, provided that all effects that degrade the quantitative content of the images have been corrected for. In addition, inhomogeneous organ accumulation of the radionuclide can be detected and possibly taken into account. The aim of this work is to provide adequate information on internal emitter dosimetry and a state-of-the-art review of the current methodology and future trends.
authors.affiliation: Department of Medical Physics, Medical School, University of Thessaly, University Hospital, Larissa, Greece. jtsoug@med.uth.gr
authors.forename: Ioannis
authors.initials: I
authors.lastname: Tsougos
authors.forename: George
authors.initials: G
authors.lastname: Loudos
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Georgoulias
authors.forename: Kiki
authors.initials: K
authors.lastname: Theodorou
authors.forename: Constantin
authors.initials: C
authors.lastname: Kappas
mesh_terms: D006801:Humans; D021621:Imaging, Three-Dimensional; D019047:Phantoms, Imaging; D057285:Precision Medicine / Q000379:methods* / Q000639:trends; D011868:Radioisotopes; D011874:Radiometry / Q000379:methods* / Q000639:trends; D012984:Software
chemical_list: D011868:Radioisotopes