Getting connected in the globin interactome.
A new study provides compelling evidence that transcriptional regulation and three-dimensional genomic architecture are linked. The alpha- and beta-globin loci associate with hundreds of active genes across the genome at transcription factories in erythroid cells, and specialized Klf1-containing transcription factories mediate the association of Klf1-regulated genes.
Ragoczy
Tobias
T
Groudine
Mark
M
D000818:Animals; D041905:Erythroid Cells / Q000166:cytology / Q000378:metabolism*; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks / Q000235:genetics*; D055106:Genome-Wide Association Study; D005914:Globins / Q000235:genetics* / Q000378:metabolism; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D020411:Oligonucleotide Array Sequence Analysis
D051741:Kruppel-Like Transcription Factors; C080774:erythroid Kruppel-like factor; D005914:Globins