Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma.
We analyzed the expression of Id-1 in oral squamous cell carcinoma (OSCC) immunohistochemically, and investigated the association of Id-1 expression with tumor angiogenesis and clinical prognosis. Overexpression of Id-1 protein was found in 83 out of 128 cases (64.8%). The expression of Id-1 was significantly associated with tumor size (p=0.013), lymph node metastasis (p=0.001), tumor stage (p=0.031) and tumor recurrence (p=0.003). Moreover, Id-1 expression was significantly correlated with intratumoral microvessel density (MVD) (r=0.223, p=0.011). The results suggest that overexpression of Id-1 was correlated with tumor angiogenesis and poor clinical outcome.
Dong
Zuoqing
Z
Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University, 107 Wenhua Xi Road, Jinan 250012, PR China.
Liu
Shaohua
S
Zhou
Chengjun
C
Sumida
Tomoki
T
Hamakawa
Hiroyuki
H
Chen
Zhenggang
Z
Liu
Pei
P
Wei
Fengcai
F
D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D051798:Inhibitor of Differentiation Protein 1 / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000098:blood supply / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome; D047368:Tumor Burden; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
C497453:ID1 protein, human; D051798:Inhibitor of Differentiation Protein 1; D042461:Vascular Endothelial Growth Factor A