title: A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
abstract: BACKGROUND
  We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations.
  
  
  RESULTS
  We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P=3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P=2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P=4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval.
  
  
  CONCLUSIONS
  Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP.
authors.affiliation: Institute of Genetic Medicine, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Munich, Germany.
authors.forename: Fabio
authors.initials: F
authors.lastname: Marroni
authors.forename: Arne
authors.initials: A
authors.lastname: Pfeufer
authors.forename: Yurii S
authors.initials: YS
authors.lastname: Aulchenko
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Franklin
authors.forename: Aaron
authors.initials: A
authors.lastname: Isaacs
authors.forename: Irene
authors.initials: I
authors.lastname: Pichler
authors.forename: Sarah H
authors.initials: SH
authors.lastname: Wild
authors.forename: Ben A
authors.initials: BA
authors.lastname: Oostra
authors.forename: Alan F
authors.initials: AF
authors.lastname: Wright
authors.forename: Harry
authors.initials: H
authors.lastname: Campbell
authors.forename: Jacqueline C
authors.initials: JC
authors.lastname: Witteman
authors.forename: Stefan
authors.initials: S
authors.lastname: Kääb
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Hicks
authors.forename: Ulf
authors.initials: U
authors.lastname: Gyllensten
authors.forename: Igor
authors.initials: I
authors.lastname: Rudan
authors.forename: Thomas
authors.initials: T
authors.lastname: Meitinger
authors.forename: Cristian
authors.initials: C
authors.lastname: Pattaro
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: van Duijn
authors.forename: James F
authors.initials: JF
authors.lastname: Wilson
authors.forename: Peter P
authors.initials: PP
authors.lastname: Pramstaller
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000328:Adult; D000368:Aged; D002882:Chromosomes, Human, Pair 13; D004562:Electrocardiography; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D006339:Heart Rate / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D043562:Receptors, G-Protein-Coupled / Q000235:genetics; D044465:White People / Q000235:genetics*
chemical_list: C547021:ADGRD1 protein, human; D048868:Adaptor Proteins, Signal Transducing; C488081:NOS1AP protein, human; D043562:Receptors, G-Protein-Coupled