title: Design, synthesis and studies of triphosphate analogues for the production of anti AZT-TP antibodies.
abstract: Triphosphates anabolites are the active chemical species of nucleosidic reverse transcriptase inhibitors in HIV-therapy. Herein, we describe (i) the design of stable triphosphate analogues of AZT using molecular modelling, (ii) their synthesis and (iii) their use for producing anti AZT-TP antibodies in the aim of developing an immunoassay for therapeutic drug monitoring.
authors.affiliation: Laboratoire de Chimie des Molécules Bioactives et Arômes, UMR 6001 CNRS, Institut de Chimie de Nice, Université de Nice-Sophia Antipolis, Nice, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Roucairol
authors.forename: Stéphane
authors.initials: S
authors.lastname: Azoulay
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: Nevers
authors.forename: Jérôme
authors.initials: J
authors.lastname: Golebiowski
authors.forename: Christophe
authors.initials: C
authors.lastname: Créminon
authors.forename: Jacques
authors.initials: J
authors.lastname: Grassi
authors.forename: Alain
authors.initials: A
authors.lastname: Burger
authors.forename: Danièle
authors.initials: D
authors.lastname: Duval
mesh_terms: D000818:Animals; D000917:Antibody Formation; D054306:Dideoxynucleotides / Q000097:blood / Q000276:immunology*; D015195:Drug Design; D011122:Polyphosphates / Q000097:blood / Q000138:chemical synthesis* / Q000276:immunology*; D011817:Rabbits; D013942:Thymine Nucleotides / Q000097:blood / Q000276:immunology*; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000097:blood / Q000276:immunology
chemical_list: D054306:Dideoxynucleotides; D011122:Polyphosphates; D013942:Thymine Nucleotides; D015215:Zidovudine; C052873:zidovudine triphosphate; C005692:triphosphoric acid