Biochemistry and physiology of mitochondrial ion channels involved in cardioprotection.
Over the past decades there has been considerable progress in understanding the multifunctional roles of mitochondrial ion channels in metabolism, energy transduction, ion transport, signaling, and cell death. Recent data have suggested that some of these channels function under physiological condition, and others may be activated in response to pathological insults and play a key role in cytoprotection. This review outlines our current understanding of the molecular identity and pathophysiological roles of the mitochondrial ion channels in the heart with particular emphasis on cardioprotection against ischemia/reperfusion injury, and future research on mitochondrial ion channels.
Nishida
Hirofumi
H
Department of Pharmacology, Chiba University Graduate School of Medicine, Chiba, Japan. hinishida@faculty.chiba-u.jp
Matsumoto
Akio
A
Tomono
Naohiro
N
Hanakai
Takahiro
T
Harada
Shintaro
S
Nakaya
Haruaki
H
D000818:Animals; D002316:Cardiotonic Agents / Q000378:metabolism; D006321:Heart / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism; D000083162:Mitochondrial Permeability Transition Pore; D009206:Myocardium / Q000378:metabolism*; D010829:Physiological Phenomena
D002316:Cardiotonic Agents; D007473:Ion Channels; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore