title: Clinical utility of varenicline for smokers with medical and psychiatric comorbidity.
abstract: Chronic obstructive pulmonary disease (COPD) is a costly and deadly disease afflicting an estimated 210 million people and accounting for 5% of all global deaths. Exposure to cigarette smoke is the greatest risk factor for COPD in the developed world. Smoking cessation improves respiratory symptoms and lung function and reduces mortality among patients with COPD. Cigarette smokers with COPD and other co-morbid conditions such as cardiovascular disease and psychiatric illnesses should receive comprehensive tobacco treatment interventions incorporating efficacious pharmacotherapies. Varenicline, an alpha(4)beta(2) nicotinic acetylcholine receptor partial agonist, is the newest and most effective drug currently available to promote smoking cessation. In conjunction with behavioral interventions and clinical monitoring for potential side effects, varenicline offers great hope for reducing smoking-attributable death and disability.
authors.affiliation: Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA. ebbert.jon@mayo.edu
authors.forename: Jon O
authors.initials: JO
authors.lastname: Ebbert
authors.forename: Kirk D
authors.initials: KD
authors.lastname: Wyatt
authors.forename: Ali
authors.initials: A
authors.lastname: Zirakzadeh
authors.forename: Michael V
authors.initials: MV
authors.lastname: Burke
authors.forename: Jt
authors.initials: J
authors.lastname: Hays
mesh_terms: D001552:Benzazepines / Q000008:administration & dosage / Q000627:therapeutic use*; D002318:Cardiovascular Diseases; D004348:Drug Labeling; D006801:Humans; D001523:Mental Disorders / Q000150:complications; D018722:Nicotinic Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D029424:Pulmonary Disease, Chronic Obstructive; D011810:Quinoxalines / Q000008:administration & dosage / Q000627:therapeutic use*; D012907:Smoking / Q000188:drug therapy*; D016540:Smoking Cessation; D014029:Tobacco Use Disorder / Q000150:complications / Q000188:drug therapy; D016896:Treatment Outcome; D000068580:Varenicline
chemical_list: D001552:Benzazepines; D018722:Nicotinic Agonists; D011810:Quinoxalines; D000068580:Varenicline