Antioxidant and antiviral activities of silybin fatty acid conjugates.
Two selective acylation methods for silybin esterification with long-chain fatty acids were developed, yielding a series of silybin 7-O- and 23-O-acyl-derivatives of varying acyl chain lengths. These compounds were tested for their antioxidant (inhibition of lipid peroxidation and DPPH-scavenging) and anti-influenza virus activities. The acyl chain length is an important prerequisite for both biological activities, as they improved with increasing length of the acyl moiety.
Gazák
Radek
R
Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídenská 1083, CZ-142 20 Prague, Czech Republic.
Purchartová
Katerina
K
Marhol
Petr
P
Zivná
Lucie
L
Sedmera
Petr
P
Valentová
Katerina
K
Kato
Nobuo
N
Matsumura
Hiroyo
H
Kaihatsu
Kunihiro
K
Kren
Vladimír
V
D000215:Acylation; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004285:Dogs; D004951:Esterification; D005227:Fatty Acids / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009975:Orthomyxoviridae / Q000187:drug effects*; D000077385:Silybin; D012838:Silymarin / Q000494:pharmacology*
D000975:Antioxidants; D000998:Antiviral Agents; D005227:Fatty Acids; D012838:Silymarin; D000077385:Silybin