Circulating procoagulant microparticles in acute pulmonary embolism: a case-control study.
We investigated whether circulating procoagulant microparticles (CPMPs) contributed to hypercoagulability in 45 patients with acute pulmonary embolism (APE) and in 45 controls with and 45 controls without cardiovascular risk factors. Concentrations of CPMPs and platelet-derived microparticles (PMPs) were statistically significantly higher in patients with APE than in controls without cardiovascular risk factors. PMPs appeared to be the main source of procoagulant microparticle release in APE, but this correlation disappeared when APE patients were compared to controls with cardiovascular risk factors. CPMPs may have a role in venous thrombosis as mediators of cardiovascular risk factors.
Bal
Laurence
L
Cardiology Department, Saint-Antoine University and Medical School, France; Université Pierre et Marie Curie, Paris, France.
Ederhy
Stéphane
S
Cardiology Department, Saint-Antoine University and Medical School, France; Université Pierre et Marie Curie, Paris, France.
Di Angelantonio
Emanuele
E
Cardiology Department, Saint-Antoine University and Medical School, France; Université Pierre et Marie Curie, Paris, France.
Toti
Florence
F
INSERM U.770, Hôpital de Bicêtre, Université Louis Pasteur, Faculté de Médecine, Institut d'Hématologie et Immunologie, Strasbourg, France.
Zobairi
Fatiha
F
INSERM U.770, Hôpital de Bicêtre, Université Louis Pasteur, Faculté de Médecine, Institut d'Hématologie et Immunologie, Strasbourg, France.
Dufaitre
Ghislaine
G
Cardiology Department, Saint-Antoine University and Medical School, France; Université Pierre et Marie Curie, Paris, France.
Meuleman
Catherine
C
Cardiology Department, Saint-Antoine University and Medical School, France; Université Pierre et Marie Curie, Paris, France.
Mallat
Ziad
Z
INSERM U970 Paris Cardiovascular Research Center PARCC, Paris, France and Université Paris Descartes UMR-S970, Paris, France.
Boccara
Franck
F
Cardiology Department, Saint-Antoine University and Medical School, France; Université Pierre et Marie Curie, Paris, France.
Tedgui
Alain
A
INSERM U970 Paris Cardiovascular Research Center PARCC, Paris, France and Université Paris Descartes UMR-S970, Paris, France.
Freyssinet
Jean Marie
JM
INSERM U.770, Hôpital de Bicêtre, Université Louis Pasteur, Faculté de Médecine, Institut d'Hématologie et Immunologie, Strasbourg, France.
Cohen
Ariel
A
Cardiology Department, Saint-Antoine University and Medical School, France; Université Pierre et Marie Curie, Paris, France. Electronic address: ariel.cohen@sat.aphp.fr.
D000208:Acute Disease; D001777:Blood Coagulation / Q000502:physiology; D016022:Case-Control Studies; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D006801:Humans; D011655:Pulmonary Embolism / Q000097:blood* / Q000175:diagnosis; D012307:Risk Factors