title: Antidiabetic Activity of the Ethanol Extract of Capparis sepiaria L Leaves.
abstract: Capparis sepiaria L, a profusely branched hedge plant, is used in Indian traditional medicine. Capparis sepiaria leaves were extracted with ethanol and concentrated to dryness. The LD(50) value was determined as 894.43 mg/kg body weight by acute toxicity study. The ethanol extract was investigated for possible hypoglycemic effect produced by single oral administration at various dose levels 100, 200 and 300 mg/kg in the streptozotocin induced diabetic rats and compared against normal saline control and the standard glibenclamide. A maximum fall of plasma glucose level 9.40%; 13.57%; 15.25% and 18.80% was observed after 12 h of treatment when administered with ethanol extract of Capparis sepiaria at 100, 200 and 300 mg/kg, and glibenclamide 10 mg/kg dose, respectively. The findings from the study suggest that the Capparis sepiaria leaves may be prescribed as an adjunct to traditional formulation and drug treatment for controlling diabetes mellitus.
authors.affiliation: Department of Pharmaceutical Technology, Bharathidasan Institute of Technology, Anna University, Tiruchirappalli-620 024, India.
authors.forename: P
authors.initials: P
authors.lastname: Selvamani
authors.forename: S
authors.initials: S
authors.lastname: Latha
authors.forename: K
authors.initials: K
authors.lastname: Elayaraja
authors.forename: P Suresh
authors.initials: PS
authors.lastname: Babu
authors.forename: J K
authors.initials: JK
authors.lastname: Gupta
authors.forename: T K
authors.initials: TK
authors.lastname: Pal
authors.forename: L K
authors.initials: LK
authors.lastname: Ghosh
authors.forename: D J
authors.initials: DJ
authors.lastname: Sen