Galectin-8 up-regulation during hypopharyngeal and laryngeal tumor progression and comparison with galectin-1, -3 and -7.
OBJECTIVE
To define specific staining patterns for the adhesion/growth-regulatory lectin tandem-repeat-type galectin-8 in hypopharyngeal and laryngeal tumor progression and relate these parameters to galectins 1, 3 and 7 in the quest to explore the galectin network.


METHODS
The level of expression of galectin-8 was determined immunohistochemically in a series of 18 and 16 cases of tumor-free epithelium, 24 and 10 cases of low-grade dysplasia, 22 and 15 cases of high-grade dysplasia located in peri-tumoral area of 74 and 37 hypopharyngeal and laryngeal carcinomas.


RESULTS
Marked upregulation in galectin-8 staining intensity and immunopositive area in malignancy versus dysplasia was seen in hypopharyngeal cancer (p<10(-6)), in laryngeal cancer for labeling index and high-grade dysplasia/carcinoma (p<10(-6)). No correlation to recurrence was delineated.


CONCLUSIONS
The presented data revealed a divergence within the galectin-1, -3, -7 and -8 network during tumor progression.
Cludts
Stéphanie
S
Laboratory of Anatomy, Faculty of Medicine and Pharmacy, University of Mons-Hainaut, Pentagone 1B - Avenue du Champ de Mars, 6, B-7000 Mons, Belgium.
Decaestecker
Christine
C
Mahillon
Virginie
V
Chevalier
Dominique
D
Kaltner
Herbert
H
André
Sabine
S
Remmelink
Myriam
M
Leroy
Xavier
X
Gabius
Hans-Joachim
HJ
Saussez
Sven
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D015153:Blotting, Western; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000556:secondary / Q000628:therapy; D003131:Combined Modality Therapy; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D037483:Galectin 1 / Q000378:metabolism*; D037502:Galectin 3 / Q000378:metabolism*; D037161:Galectins / Q000276:immunology / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D007124:Immunoenzyme Techniques; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D007830:Larynx / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010614:Pharynx / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D011817:Rabbits; D012189:Retrospective Studies; D015854:Up-Regulation
D037483:Galectin 1; D037502:Galectin 3; D037161:Galectins; C092525:LGALS7 protein, human; C091991:LGALS8 protein, human