Transcatheter closure of moderate-to-large patent ductus arteriosus in infants using Amplatzer duct occluder.
BACKGROUND
There are difficulties in transcatheter closure of patent ductus arteriosus (PDA) in infants.


RESULTS
The 46 infants (mean age 6.2+/-2.7 months; mean body weight 6.3+/-1.6 kg) who underwent PDA closure using the Amplatzer duct occluder (ADO). The indication for using an ADO was a ductus diameter > or =2.5 or 3 mm. Device diameter selected was 1-3 mm larger than ductal diameter. The mean systolic pulmonary artery pressure was 40.9+/-18.2 mmHg. The mean Qp/Qs ratio was 3.1+/-1.2. The mean ductus diameter was 3.3+/-0.8 mm. ADO was successfully deployed in 45 patients. Failure occurred in 1 case. The mean diameter of device used was 5.4+/-1.1 mm. No severe complications occurred. At the 1-month echocardiographic follow-up, a small residual shunt was present in 4 of 45 patients and had disappeared in all 4 patients at the 3-month follow-up. One patient developed a moderate degree of left ventricular outflow tract obstruction 2.3 years after the procedure.


CONCLUSIONS
Transcatheter closure of PDA in infants using the ADO is a safe and effective method.
Wang
Jou-Kou
JK
Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. jkww@ntuh.gov.tw
Wu
Mei-Hwan
MH
Lin
Ming-Tai
MT
Chiu
Shuenn-Nan
SN
Chen
Chun-An
CA
Chiu
Hsin-Hui
HH
D001027:Aortography; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation*; D002675:Child, Preschool; D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D011474:Prosthesis Design; D011475:Prosthesis Failure; D055989:Septal Occluder Device; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography