[The IL-6 and COX-2 expression related to sensitivity of chemoradiotherapy and prognosis in esophageal carcinoma].
Chemoradiation therapy (CRT) for esophageal cancer induces inflammatory responses within tumor tissues. Inflammatory cells infiltrated into the tumor tissues may modulate the CRT responses via inflammation-related molecules such as IL-6 or COX-2. In the present study, we investigated a relationship between IL-6/COX-2 expression and CRT responses for esophageal cancer. A surgical resection following CRT was performed, and the specimens from the patients with cT3/T4 esophageal squamous cell examined for IL-6/COX-2 expression in both residual cancer and stromal cells by immunohistochemical staining. CRT responses were divided into responder group (Grade 1b and Grade 2) and non-responder group (Grade 1a). COX-2 in cancer cells and IL-6 in stromal cells were associated with non-responder and responder, respectively. In addition, IL-6 in stromal cells was significantly correlated with overall survival. Our data suggest that inflammatory responses concomitant with CRT responses could play a role in chemoradiation responses and prognosis.
Okamura
Shinichi
S
Department of Surgery, Division of Digestive Surgery, Kyoto Prefectural University of Medicine.
Fujiwara
Hitoshi
H
Suchi
Kentaro
K
Okamura
Hiroko
H
Umehara
Seiji
S
Todo
Momoko
M
Kuriu
Yoshiaki
Y
Ikoma
Hisashi
H
Kubota
Takeshi
T
Nakanishi
Masayoshi
M
Ichikawa
Daisuke
D
Kikuchi
Shojiro
S
Okamoto
Kazuma
K
Ochiai
Toshiya
T
Sakakura
Chouhei
C
Kokuba
Yukihito
Y
Sonoyama
Teruhisa
T
Otsuji
Eigo
E
D003131:Combined Modality Therapy; D051546:Cyclooxygenase 2 / Q000032:analysis*; D004938:Esophageal Neoplasms / Q000737:chemistry / Q000401:mortality / Q000628:therapy*; D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000032:analysis*; D011379:Prognosis; D012189:Retrospective Studies
D015850:Interleukin-6; D051546:Cyclooxygenase 2