title: The temperature-dependent hydrogen-bonding signature of lipids monitored in the far-infrared domain.
abstract: Phospholipids are studied by means of Fourier transform infrared (FTIR) spectroscopy in the mid- and far-infrared spectral ranges, thereby establishing the hydrogen-bonding continuum as a function of the temperature. The well-known mid-infrared spectrum of the phospholipid layer clearly shows a temperature-dependent phase transition. In the far-infrared region (from 300 to 50 cm(-1)), an alternation of the interaction between the phospholipids and water molecules is found. The hydrogen-bonding network ensemble and bound water molecules can be monitored in this spectral region. The lipid structure is found to strongly influence the intermolecular hydrogen-bonding interplay. Thus, studies in the far-infrared region provide significant information--at the molecular level--about the intermolecular hydrogen-bonding signature of self-assembled phospholipids.
authors.affiliation: Laboratoire de Spectroscopie Vibrationnelle et Electrochimie des Biomolécules, Institut de Chimie UMR 7177, Université de Strasbourg, 1 rue Blaise Pascal, 67000 Strasbourg Cedex, France.
authors.forename: Ruth
authors.initials: R
authors.lastname: Hielscher
authors.forename: Petra
authors.initials: P
authors.lastname: Hellwig
mesh_terms: D001665:Binding Sites; D002712:Chlorides / Q000737:chemistry; D006860:Hydrogen Bonding / Q000187:drug effects*; D008055:Lipids / Q000737:chemistry; D008560:Membrane Fluidity / Q000502:physiology; D010743:Phospholipids / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D002712:Chlorides; D008055:Lipids; D010743:Phospholipids; D014867:Water