Aziridines as intermediates in diversity-oriented syntheses of alkaloids.
The efficient synthesis of small molecules that collectively comprise optimal small-molecule screening collections is an important goal. With this in mind, we have used N-alkyl aziridines in a regio- and stereochemically controlled synthesis of polycyclic heterocycles based on nucleophilic ring opening and subsequent intramolecular cyclization.
Taylor
Alexander M
AM
Howard Hughes Medical Institute Broad Institute of Harvard and MIT 7 Cambridge Center, Cambridge, MA 02142 stuart_schreiber@harvard.edu.
Schreiber
Stuart L
SL