title: Clindamycin-resistant group B Streptococcus and failure of intrapartum prophylaxis to prevent early-onset disease.
abstract: Guidelines recommend intrapartum antibiotic prophylaxis (IAP) for parturient women who have a screen positive for group B Streptococcus (GBS). Clindamycin should be used for IAP only if the maternal GBS isolate is susceptible. We report a case of clindamycin-resistant GBS disease in a newborn infant whose mother received clindamycin IAP, and we review clindamycin susceptibility testing.
authors.affiliation: Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA. anne.blaschke@hsc.utah.edu
authors.forename: Anne J
authors.initials: AJ
authors.lastname: Blaschke
authors.forename: Laurie S
authors.initials: LS
authors.lastname: Pulver
authors.forename: E Kent
authors.initials: EK
authors.lastname: Korgenski
authors.forename: Lucy A
authors.initials: LA
authors.lastname: Savitz
authors.forename: Judy A
authors.initials: JA
authors.lastname: Daly
authors.forename: Carrie L
authors.initials: CL
authors.lastname: Byington
mesh_terms: D019072:Antibiotic Prophylaxis; D002981:Clindamycin / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008297:Male; D008826:Microbial Sensitivity Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D013290:Streptococcal Infections / Q000188:drug therapy / Q000517:prevention & control*; D013292:Streptococcus agalactiae / Q000187:drug effects
chemical_list: D002981:Clindamycin