title: Neopterin: Biomarker of cell-mediated immunity and potent usage as biomarker in silicosis and other occupational diseases.
abstract: Neopterin is regarded as an early biomarker of the cellular immune response. This low molecular mass compound belongs to the class of pteridine and is a metabolite of guanosine triphosphate, which is produced by the activated macrophages and dendritic cells after stimulation with gamma-interferon. An international group acknowledges the fact that the levels of serum neopterin can be used as a marker of the effect of exposure to silica and other occupational diseases. The determination of neopterin is an innovative tool for monitoring diseases associated with the activation of cell-mediated immunity.
authors.affiliation: National Institute of Miner's Health, JNARDDC Campus, Nagpur, India.
authors.forename: Shubhangi K
authors.initials: SK
authors.lastname: Pingle
authors.forename: Rajani G
authors.initials: RG
authors.lastname: Tumane
authors.forename: Aruna A
authors.initials: AA
authors.lastname: Jawade