title: Polymyxin B-immobilized fiber column hemoperfusion treatment for drug-induced severe respiratory failure: report of three cases.
abstract: The effects of direct hemoperfusion with polymyxin B-immobilized fiber (PMX-DHP) treatment for acute exacerbation of interstitial pneumonia have been reported. Here, we report 3 severe cases of drug-induced interstitial lung disease (DI-ILD) that were treated with PMX-DHP. Two DI-ILD cases were caused by methotrexate, and the third case was caused by the herbal medicine sanmotsu-ogon-to. The arterial oxygen tension/inspiratory oxygen fraction ratio improved during PMX-DHP treatment in all 3 patients. Finally, 2 patients survived and 1 died. The study findings indicate that PMX-DHP treatment is a viable option for the management of acute respiratory failure in patients with DI-ILD.
authors.affiliation: The First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsushima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Michiko
authors.initials: M
authors.lastname: Ito
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Agatsuma
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Kozumi
authors.forename: Keishi
authors.initials: K
authors.lastname: Kubo
mesh_terms: D000368:Aged; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D055767:Immobilized Proteins; D017563:Lung Diseases, Interstitial / Q000139:chemically induced / Q000628:therapy; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D010936:Plant Extracts / Q000009:adverse effects*; D011112:Polymyxin B; D012131:Respiratory Insufficiency / Q000139:chemically induced* / Q000628:therapy*
chemical_list: D055767:Immobilized Proteins; D010936:Plant Extracts; D011112:Polymyxin B; D008727:Methotrexate