title: [Neoadjuvant chemotherapy and pancreatoduodenectomy for locally advanced colon cancer].
abstract: A 62-year-old man was referred to our hospital with the chief complaint of a palpable abdominal mass. Type 1 tumor was found in the ascending colon on fiberscopic examination, and pathologic examination revealed moderate to highly differentiated adenocarcinoma. Computed tomography of the abdomen demonstrated a main tumor and an adjacent large mass which was suspected to be lymph node metastasis. The tumor invaded the superior mesenteric vein( SMV) and pancreas. On the first laparotomy, a curative resection was difficult, and chemotherapy was planned. The FOLFIRI regimen was effective, but adverse events such as fever and general fatigue gradually became pronounced. Even after the change to FOLFOX, these adverse events did not improve, and we therefore decided to perform a radical resection. The patient is still alive and disease-free 8 months after surgery.
authors.affiliation: Department of Surgery, National Hospital Organization, Osaka National Hospital.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Miki
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ikenaga
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miyamoto
authors.forename: Masanori
authors.initials: M
authors.lastname: Tsujie
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Yasui
authors.forename: Michihiko
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Motohiro
authors.initials: M
authors.lastname: Hirao
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Fujitani
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Mishima
authors.forename: Shoji
authors.initials: S
authors.lastname: Nakamori
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Tsujinaka
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002166:Camptothecin / Q000031:analogs & derivatives / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000473:pathology / Q000628:therapy*; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D016577:Pancreaticoduodenectomy
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin