In vivo pharmacokinetics of bakuchiol after oral administration of bakuchiol extraction in rat plasma.
BACKGROUND
Psoralea corylifolia L. (Fabaceae) was a traditional Chinese medicine for the treatment of various skin diseases such as psoriasis, vitiligo and chronic graft-versus-host, and has been proved to show anticancer, cytotoxic, anti-bacterial, cardiac, diaphoretic, diuretic, stimulant, aphrodisiac and tonic effects. Bakuchiol was one of the main active ingredients of this traditional Chinese medicine.


OBJECTIVE
In this paper, pharmacokinetic study was conducted to obtain pharmacokinetic parameters of bakuchiol.


METHODS
Bakuchiol was enriched using resin inform the ethanol extract of Psoralea corylifolia L., HPLC-UV was used to determine the concentration of bakuchiol in rat plasma at different time points after administration. The main pharmacokinetic parameters of bakuchiol in rat were obtained based on the analysis of the plasma sample.


RESULTS
The pharmacokinetics of bakuchiol was fitted with a two-compartment model and it was eliminated relative slowly in rats.


CONCLUSIONS
The HPLC-UV method was successfully applied to study the pharmacokinetics of bakuchiol in rats.
Yan
Dong-Mei
DM
The Key Laboratory for Prescription of National Educational Ministry of China, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Chang
Yan-Xu
YX
Wang
Yue-Fei
YF
Liu
Er-Wei
EW
Li
Jin
J
Kang
Li-Yuan
LY
Gao
Xiu-Mei
XM
D000284:Administration, Oral; D000818:Animals; D001419:Bacteria / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D020834:Ethnopharmacology; D007887:Fabaceae / Q000737:chemistry; D005260:Female; D008297:Male; D008516:Medicine, Chinese Traditional; D010636:Phenols / Q000097:blood* / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
D010636:Phenols; C012765:bakuchiol