Cationic N-confused porphyrin derivative as a better molecule scaffold for G-quadruplex recognition.
One N-confused porphyrin derivative was prepared and its first observation that it could stabilize G-quadruplex and possessed high selectivity over duplex DNA was made, furthermore, it was also proved to possess the capacity to induce a structural transition from the antiparallel to the mixed-type hybrid G-quadruplex structure.
Du
Yuhao
Y
College of Chemistry and Molecular Sciences, State Key Laboratory of Virology, Minist Educ, Key Lab Biomed, Wuhan University, Hubei, Wuhan 430072, PR China.
Zhang
Dan
D
Chen
Wei
W
Zhang
Ming
M
Zhou
Yangyang
Y
Zhou
Xiang
X
D001483:Base Sequence; D001665:Binding Sites; D002412:Cations / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000737:chemistry; D054856:G-Quadruplexes / Q000187:drug effects*; D006801:Humans; D008958:Models, Molecular; D011166:Porphyrins / Q000737:chemistry* / Q000494:pharmacology*; D016615:Telomere / Q000737:chemistry / Q000187:drug effects
D002412:Cations; D011166:Porphyrins; D004247:DNA