title: Genetic association of the neuropilin-1 gene with type 1 diabetes in children: Neuropilin-1 expression in pancreatic islets.
abstract: Minor alleles of two SNPs in intron 9 of the NRP1 gene, which encodes neuropilin-1, were found to be associated with type 1 diabetes (T1D) in children. Neuropilin-1 peptides were confined to islets in human pancreas. This suggests neuropilins-1 could influence the development of some cases of T1D in children.
authors.affiliation: Childrens Diabetes Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
authors.forename: Noaman M
authors.initials: NM
authors.lastname: Hasan
authors.forename: Mindy A
authors.initials: MA
authors.lastname: Kendrick
authors.forename: Noah R
authors.initials: NR
authors.lastname: Druckenbrod
authors.forename: Michael K
authors.initials: MK
authors.lastname: Huelsmeyer
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Warner
authors.forename: Michael J
authors.initials: MJ
authors.lastname: MacDonald
mesh_terms: D017668:Age of Onset; D000483:Alleles; D016009:Chi-Square Distribution; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D007515:Islets of Langerhans / Q000378:metabolism*; D039942:Neuropilin-1 / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D039942:Neuropilin-1