title: Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC.
abstract: The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by (32)P-post-labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.35-0.90), higher GSH levels (+1.87 micromol GSH g(-1) haemoglobin, p = 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.38-2.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.84-1.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.
authors.affiliation: Columbia University Mailman School of Public Health, New York, NY, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Rundle
authors.forename: John
authors.initials: J
authors.lastname: Richie
authors.forename: Karen
authors.initials: K
authors.lastname: Steindorf
authors.forename: Marco
authors.initials: M
authors.lastname: Peluso
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Ole
authors.initials: O
authors.lastname: Raaschou-Nielsen
authors.forename: Francoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Jacob P
authors.initials: JP
authors.lastname: Linseisen
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Vittorio
authors.initials: V
authors.lastname: Krogh
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Salvatore
authors.initials: S
authors.lastname: Panico
authors.forename: Hendrik B
authors.initials: HB
authors.lastname: Bueno-De-Mesquita
authors.forename: Petra H
authors.initials: PH
authors.lastname: Peeters
authors.forename: Eiliv
authors.initials: E
authors.lastname: Lund
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Gonzalez
authors.forename: Carmen
authors.initials: C
authors.lastname: Martinez
authors.forename: Miren
authors.initials: M
authors.lastname: Dorronsoro
authors.forename: Aurelio
authors.initials: A
authors.lastname: Barricarte
authors.forename: M Jose
authors.initials: MJ
authors.lastname: Tormo
authors.forename: Josèr
authors.initials: J
authors.lastname: Quiros
authors.forename: Antonio
authors.initials: A
authors.lastname: Agudo
authors.forename: Goran
authors.initials: G
authors.lastname: Berglund
authors.forename: Bengt
authors.initials: B
authors.lastname: Jarvholm
authors.forename: Sheila
authors.initials: S
authors.lastname: Bingham
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Key
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Gormally
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Saracci
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
mesh_terms: D000368:Aged; D015415:Biomarkers; D016022:Case-Control Studies; D018736:DNA Adducts / Q000032:analysis; D004912:Erythrocytes / Q000737:chemistry; D005060:Europe / Q000453:epidemiology; D005260:Female; D005978:Glutathione / Q000032:analysis; D006801:Humans; D007962:Leukocytes / Q000737:chemistry; D008175:Lung Neoplasms / Q000097:blood / Q000453:epidemiology* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology / Q000379:methods; D009043:Motor Activity; D010865:Pilot Projects; D012307:Risk Factors; D012907:Smoking
chemical_list: D015415:Biomarkers; D018736:DNA Adducts; D005978:Glutathione