title: A case with coincidental diagnosis of primary central nervous system lymphoma and lymph node sarcoidosis.
abstract: Primary central nervous system lymphoma (PCNSL) is rare. Clinical and histological differential diagnosis of systemic lymphoma and sarcoidosis continues to be a challenge. The first case report in the German and English literature of PCNSL and synchronous sarcoidosis is presented. Synchronous mediastinal lymphadenopathy suggestive of non-Hodgkin's lymphoma (NHL) or sarcoidosis was noted. Both conditions require alternative therapeutic and prognostic considerations to PCNSL. A regime of intrathecal and adjuvant systemic chemotherapy led to transient clinical improvement prior to the patient's demise through overwhelming sepsis and multiorgan failure. Post mortem findings confirmed synchronous PCNSL with mediastinal lymph node sarcoidosis.
authors.affiliation: Department of Neurology, Friedrich-Schiller-University, Erlanger Allee 101, 07740 Jena, Germany. Eva.greiner@med.uni-jena.de
authors.forename: Eva J
authors.initials: EJ
authors.lastname: Greiner
authors.forename: Lars-Olof
authors.initials: LO
authors.lastname: Mügge
authors.forename: Bernd F M
authors.initials: BF
authors.lastname: Romeike
authors.forename: Theodoros
authors.initials: T
authors.lastname: Topalidis
authors.forename: Bernhard
authors.initials: B
authors.lastname: Theis
authors.forename: Andreas
authors.initials: A
authors.lastname: Ragoschke-Schumm
authors.forename: Otto W
authors.initials: OW
authors.lastname: Witte
authors.forename: Albrecht
authors.initials: A
authors.lastname: Günther
mesh_terms: D000368:Aged; D018951:Antigens, CD20 / Q000378:metabolism; D016543:Central Nervous System Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology*; D008223:Lymphoma / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011859:Radiography; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D018951:Antigens, CD20