title: Synthesis, characterization, and cytotoxicity of some novel glycosyl thiazol-2-imines as antitumoral agents.
abstract: A series of novel glycosyl thiazol-2-imines (3a-g) have been synthesized regioselectively in good yields from the hydrolysis of thiazol-2(3H)-imine-linked glycoconjugates. The glycosyl thiazol-2-imines were evaluated for their antitumor activity against Hela (cervical carcinoma), HCT-8 (colon carcinoma) and Bel-7402 (liver carcinoma). Among the compounds screened, 1-benzoyl-4-(4-nitrophenyl)-3-beta-D-glucopyranosyl-thiazol-2(3H)-imine (3c) was found to be the most active compound against HCT-8.
authors.affiliation: College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
authors.forename: Chao
authors.initials: C
authors.lastname: Shen
authors.forename: Hui
authors.initials: H
authors.lastname: Zheng
authors.forename: Jinchao
authors.initials: J
authors.lastname: Zhang
authors.forename: Pengfei
authors.initials: P
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005947:Glucose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006027:Glycosides / Q000138:chemical synthesis / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007097:Imines / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: C548302:1-benzoyl-4-(4-nitrophenyl)-3-glucopyranosylthiazol-2(3H)-imine; D000970:Antineoplastic Agents; D006027:Glycosides; D007097:Imines; D013844:Thiazoles; D005947:Glucose