title: Regulation of enzyme activity through interactions with nanoparticles.
abstract: The structure and function of an enzyme can be altered by nanoparticles (NPs). The interaction between enzyme and NPs is governed by the key properties of NPs, such as structure, size, surface chemistry, charge and surface shape. Recent representative studies on the NP-enzyme interactions and the regulation of enzyme activity by NPs with different size, composition and surface modification are reviewed.
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
authors.forename: Zhaochun
authors.initials: Z
authors.lastname: Wu
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.|St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
authors.forename: Bing
authors.initials: B
authors.lastname: Yan
mesh_terms: D002256:Carbonic Anhydrases / Q000737:chemistry / Q000378:metabolism; D002918:Chymotrypsin / Q000037:antagonists & inhibitors / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism; D004798:Enzymes / Q000378:metabolism*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism; D010316:Particle Size; D011485:Protein Binding
chemical_list: D004791:Enzyme Inhibitors; D004798:Enzymes; D002918:Chymotrypsin; D002256:Carbonic Anhydrases