title: Lung cancer and occupation in a population-based case-control study.
abstract: The authors examined the relation between occupation and lung cancer in the large, population-based Environment And Genetics in Lung cancer Etiology (EAGLE) case-control study. In 2002-2005 in the Lombardy region of northern Italy, 2,100 incident lung cancer cases and 2,120 randomly selected population controls were enrolled. Lifetime occupational histories (industry and job title) were coded by using standard international classifications and were translated into occupations known (list A) or suspected (list B) to be associated with lung cancer. Smoking-adjusted odds ratios and 95% confidence intervals were calculated with logistic regression. For men, an increased risk was found for list A (177 exposed cases and 100 controls; odds ratio = 1.74, 95% confidence interval: 1.27, 2.38) and most occupations therein. No overall excess was found for list B with the exception of filling station attendants and bus and truck drivers (men) and launderers and dry cleaners (women). The authors estimated that 4.9% (95% confidence interval: 2.0, 7.8) of lung cancers in men were attributable to occupation. Among those in other occupations, risk excesses were found for metal workers, barbers and hairdressers, and other motor vehicle drivers. These results indicate that past exposure to occupational carcinogens remains an important determinant of lung cancer occurrence.
authors.affiliation: Unit of Epidemiology, Department of Preventive Medicine, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via San Barnaba, 8, 20122 Milano, Italy. dario.consonni@unimi.it
authors.forename: Dario
authors.initials: D
authors.lastname: Consonni
authors.forename: Sara
authors.initials: S
authors.lastname: De Matteis
authors.forename: Jay H
authors.initials: JH
authors.lastname: Lubin
authors.forename: Sholom
authors.initials: S
authors.lastname: Wacholder
authors.forename: Margaret
authors.initials: M
authors.lastname: Tucker
authors.forename: Angela Cecilia
authors.initials: AC
authors.lastname: Pesatori
authors.forename: Neil E
authors.initials: NE
authors.lastname: Caporaso
authors.forename: Pier Alberto
authors.initials: PA
authors.lastname: Bertazzi
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Landi
mesh_terms: D000328:Adult; D000368:Aged; D000395:Air Pollutants, Occupational; D002274:Carcinogens, Environmental; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology* / Q000209:etiology; D016273:Occupational Exposure / Q000706:statistics & numerical data; D016272:Occupational Health; D009790:Occupations / Q000706:statistics & numerical data; D012307:Risk Factors
chemical_list: D000395:Air Pollutants, Occupational; D002274:Carcinogens, Environmental