Proliferative and nonproliferative lesions of the rat and mouse respiratory tract.
The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the respiratory tract of laboratory rats and mice, with color photomicrographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous developmental and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for respiratory tract lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.
Renne
Roger
R
Roger Renne ToxPath Consulting, Sumner, Washington, USA.
Brix
Amy
A
Harkema
Jack
J
Herbert
Ron
R
Kittel
Birgit
B
Lewis
David
D
March
Thomas
T
Nagano
Kasuke
K
Pino
Michael
M
Rittinghausen
Susanne
S
Rosenbruch
Martin
M
Tellier
Pierre
P
Wohrmann
Thomas
T
D000818:Animals; D000830:Animals, Laboratory; D019570:Inhalation Exposure; D007390:International Agencies; D038622:Internationality; D051379:Mice; D051381:Rats; D012137:Respiratory System / Q000473:pathology*; D012140:Respiratory Tract Diseases / Q000175:diagnosis / Q000473:pathology* / Q000662:veterinary; D012142:Respiratory Tract Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000662:veterinary; D012376:Rodent Diseases / Q000473:pathology; D009626:Terminology as Topic; D018675:Toxicity Tests