Alkyne [3 + 2] cycloadditions of iodosydnones toward functionalized 1,3,5-trisubstituted pyrazoles.
The cycloaddition of 4-iodosydnones with terminal alkynes proceeds with excellent regiocontrol to provide 5-iodo pyrazoles. These products participate smoothly in subsequent C-C and C-heteroatom bond forming processes.
Browne
Duncan L
DL
Department of Chemistry, University of Sheffield, Sheffield S3 7HF, UK.
Taylor
John B
JB
Plant
Andrew
A
Harrity
Joseph P A
JP