title: The continuum of growth hormone-IGF-I axis defects causing short stature: diagnostic and therapeutic challenges.
abstract: The growth hormone (GH)-IGF-I axis is essential for normal foetal and childhood growth. Defects at different sites in the axis frequently result in short stature which may compromise adult height. We describe a continuum of clinically relevant abnormalities from GH deficiency through to GH resistance and discuss the implementation and interpretation of investigations. We consider appropriate therapy for patients with abnormal auxology and subnormal adult height prognosis, highlighting new data to clarify therapeutic choices leading to optimal clinical outcome.
authors.affiliation: Department of Endocrinology, William Harvey Research Institute, Barts and the Royal London School of Medicine & Dentistry, London, UK. m.o.savage@qmul.ac.uk
authors.forename: Martin O
authors.initials: MO
authors.lastname: Savage
authors.forename: Christine P
authors.initials: CP
authors.lastname: Burren
authors.forename: Ron G
authors.initials: RG
authors.lastname: Rosenfeld
mesh_terms: D000328:Adult; D000465:Algorithms; D001827:Body Height / Q000235:genetics*; D003940:Diagnostic Techniques, Endocrine; D006130:Growth Disorders / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D019382:Human Growth Hormone / Q000235:genetics*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I