title: Relationship between obesity and incident diabetes in middle-aged and older Japanese adults: the Ibaraki Prefectural Health Study.
abstract: OBJECTIVE
  To investigate the age-specific relationship between body mass index (BMI) and risk of diabetes in a Japanese general population.
  
  
  METHODS
  A cohort of Japanese men (N=19,926) and women (N=41,489) (aged 40-79 years) who under went community-based health checkups in 1993 and were free of diabetes was followed up by annual examinations with measurement of blood glucose concentrations until the end of 2006. Incident diabetes mellitus was defined as a blood glucose concentration of 126 mg/dL or greater under fasting conditions, 200 mg/dL or greater under nonfasting conditions, or diabetic medication use at baseline. Hazard ratios (HRs) for diabetes according to BMI were estimated using a Cox proportional hazard model. The model was adjusted for possible confounding variables.
  
  
  RESULTS
  A total of 4429 participants (7.2%) developed diabetes (2065 men and 2364 women) during a mean follow-up of 5.5 years. Compared with those with a BMI of less than 25.0, the multivariate HRs for diabetes among participants with a BMI of 30.0 or greater were 1.40 (95% confidence interval [CI], 0.89-2.20) for men aged 40 to 59 years and 1.26 (95% CI, 0.81-1.96) for men aged 60 to 79 years (P=.002 for interaction). The HRs were 2.50 (95% CI, 2.01-3.11) for women aged 40 to 59 years and 1.80 (95% CI, 1.41-2.30) for women aged 60 to 79 years (P=.04 for interaction).
  
  
  CONCLUSIONS
  The effect of obesity on the risk of diabetes is greater for middle-aged than for older adults.
authors.affiliation: Ibaraki Health Plaza, Ibaraki, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sasai
authors.forename: Toshimi
authors.initials: T
authors.lastname: Sairenchi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
authors.forename: Fujiko
authors.initials: F
authors.lastname: Irie
authors.forename: Emiko
authors.initials: E
authors.lastname: Otaka
authors.forename: Kiyoji
authors.initials: K
authors.lastname: Tanaka
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ota
authors.forename: Takashi
authors.initials: T
authors.lastname: Muto
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D001786:Blood Glucose