Effects of atypical (risperidone) and typical (haloperidol) antipsychotic agents on astroglial functions.
Although classical and atypical antipsychotics may have different neurotoxic effects, their underlying mechanisms remain to be elucidated, especially regarding neuroglial function. In the present study, we compared the atypical antipsychotic risperidone (0.01-10 μM) with the typical antipsychotic haloperidol (0.01-10 μM) regarding different aspects such as glutamate uptake, glutamine synthetase (GS) activity, glutathione (GSH) content, and intracellular reactive oxygen species (ROS) production in C6 astroglial cells. Risperidone significantly increased glutamate uptake (up to 27%), GS activity (14%), and GSH content (up to 17%). In contrast, haloperidol was not able to change any of these glial functions. However, at concentration of 10 μM, haloperidol increased (12%) ROS production. Our data contribute to the clarification of different hypothesis concerning the putative neural responses after stimulus with different antipsychotics, and may establish important insights about how brain rewiring could be enhanced.
Quincozes-Santos
André
A
Neuroglial Plasticity Laboratory, Postgraduate Programme of Biochemistry, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo-Bairro Santa Cecilia, Porto Alegre, RS, 90035-003, Brazil.
Bobermin
Larissa Daniele
LD
Tonial
Rafaela Pestana Leques
RP
Bambini-Junior
Victorio
V
Riesgo
Rudimar
R
Gottfried
Carmem
C
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001253:Astrocytes / Q000187:drug effects* / Q000502:physiology; D001923:Brain Chemistry / Q000187:drug effects; D002460:Cell Line; D005974:Glutamate-Ammonia Ligase / Q000032:analysis* / Q000502:physiology; D018698:Glutamic Acid / Q000032:analysis / Q000502:physiology; D005978:Glutathione / Q000032:analysis / Q000502:physiology; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D017382:Reactive Oxygen Species / Q000032:analysis; D018967:Risperidone / Q000494:pharmacology*; D012559:Schizophrenia / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology
D014150:Antipsychotic Agents; D017382:Reactive Oxygen Species; D018698:Glutamic Acid; D005974:Glutamate-Ammonia Ligase; D005978:Glutathione; D006220:Haloperidol; D018967:Risperidone