title: Synthesis and configurational stability of (S)- and (R)-deuteriothalidomides.
abstract: 3'-Deuteriothalidomide was synthesized and found to be configurationally five times more stable than thalidomide toward racemization at physiological pH.
authors.affiliation: Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Nagoya, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Etsuko
authors.initials: E
authors.lastname: Tokunaga
authors.forename: Shuichi
authors.initials: S
authors.lastname: Nakamura
authors.forename: Norio
authors.initials: N
authors.lastname: Shibata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Toru
mesh_terms: D003903:Deuterium / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013723:Teratogens / Q000138:chemical synthesis / Q000737:chemistry*; D013792:Thalidomide / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D013723:Teratogens; D013792:Thalidomide; D003903:Deuterium