title: Size-reduced lung transplantation in children--an option worth to consider!
abstract: Lung transplantation is an accepted therapy for pediatric end-stage lung disease. However, there is a shortage of suitable donor organs. Therefore, the use of downsized lung allografts seems a valuable option. We report our experience of downsized pediatric lung transplantation in comparison with standard full-size pediatric lung transplantation over one decade. Pediatric recipients undergoing downsized or standard lung transplantation were included (January 1997-December 2006). We compared pretransplant clinical data and surgical and post-operative complications and post-transplant outcome. Ten pediatric lung transplants were performed (median patient age 15.6 yr [12.3-17.8]). Nine of 10 patients had CF. Five patients underwent standard full-size lung transplantation; five had downsized lung transplants. "Downsized" recipients had significantly lower median height and weight Z-scores. Donor/recipient length difference was significantly greater in the "Downsized" Group (p<0.05). All patients had comparable post-transplant functional outcome without additional surgical complications or morbidities in "downsized" recipients. Median post-transplant survival was 65 months (5-77) in the "Standard" Group compared to 86 months (64-121) in the "Downsized" Group (p=0.1). Our data suggest that downsized lung transplantation in pediatric recipients may have post-transplant outcomes comparable to full-size lung transplantation without significant complications.
authors.affiliation: Division of Pulmonary Medicine, University Hospital Zurich, Zurich, Switzerland. christian_benden@yahoo.de
authors.forename: Christian
authors.initials: C
authors.lastname: Benden
authors.forename: Ilhan
authors.initials: I
authors.lastname: Inci
authors.forename: Walter
authors.initials: W
authors.lastname: Weder
authors.forename: Annette
authors.initials: A
authors.lastname: Boehler
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D002648:Child; D005260:Female; D006801:Humans; D016040:Lung Transplantation / Q000379:methods*; D008297:Male; D009929:Organ Size; D011183:Postoperative Complications; D012189:Retrospective Studies; D016019:Survival Analysis; D014019:Tissue Donors / Q000706:statistics & numerical data; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014850:Waiting Lists