title: A genome-wide survey of human short-term memory.
abstract: Recent advances in the development of high-throughput genotyping platforms allow for the unbiased identification of genes and genomic sequences related to heritable traits. In this study, we analyzed human short-term memory, which refers to the ability to remember information over a brief period of time and which has been found disturbed in many neuropsychiatric conditions, including schizophrenia and depression. We performed a genome-wide survey at 909 622 polymorphic loci and report six genetic variations significantly associated with human short-term memory performance after genome-wide correction for multiple comparisons. A polymorphism within SCN1A (encoding the α subunit of the type I voltage-gated sodium channel) was replicated in three independent populations of 1699 individuals. Functional magnetic resonance imaging during an n-back working memory task detected SCN1A allele-dependent activation differences in brain regions typically involved in working memory processes. These results suggest an important role for SCN1A in human short-term memory.
authors.affiliation: Division of Molecular Psychology, University of Basel, Basel, Switzerland. andreas.papas@unibas.ch or
authors.forename: A
authors.initials: A
authors.lastname: Papassotiropoulos
authors.forename: K
authors.initials: K
authors.lastname: Henke
authors.forename: E
authors.initials: E
authors.lastname: Stefanova
authors.forename: A
authors.initials: A
authors.lastname: Aerni
authors.forename: A
authors.initials: A
authors.lastname: Müller
authors.forename: P
authors.initials: P
authors.lastname: Demougin
authors.forename: C
authors.initials: C
authors.lastname: Vogler
authors.forename: J C
authors.initials: JC
authors.lastname: Sigmund
authors.forename: L
authors.initials: L
authors.lastname: Gschwind
authors.forename: K-D
authors.initials: KD
authors.lastname: Huynh
authors.forename: D
authors.initials: D
authors.lastname: Coluccia
authors.forename: C R
authors.initials: CR
authors.lastname: Mondadori
authors.forename: J
authors.initials: J
authors.lastname: Hänggi
authors.forename: A
authors.initials: A
authors.lastname: Buchmann
authors.forename: V
authors.initials: V
authors.lastname: Kostic
authors.forename: I
authors.initials: I
authors.lastname: Novakovic
authors.forename: H
authors.initials: H
authors.lastname: van den Bussche
authors.forename: H
authors.initials: H
authors.lastname: Kaduszkiewicz
authors.forename: S
authors.initials: S
authors.lastname: Weyerer
authors.forename: H
authors.initials: H
authors.lastname: Bickel
authors.forename: S
authors.initials: S
authors.lastname: Riedel-Heller
authors.forename: M
authors.initials: M
authors.lastname: Pentzek
authors.forename: B
authors.initials: B
authors.lastname: Wiese
authors.forename: M
authors.initials: M
authors.lastname: Dichgans
authors.forename: M
authors.initials: M
authors.lastname: Wagner
authors.forename: F
authors.initials: F
authors.lastname: Jessen
authors.forename: W
authors.initials: W
authors.lastname: Maier
authors.forename: D J-F
authors.initials: DJ
authors.lastname: de Quervain
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000098:blood supply; D003625:Data Collection; D005060:Europe; D005260:Female; D020869:Gene Expression Profiling; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007391:International Cooperation; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D062550:NAV1.1 Voltage-Gated Sodium Channel; D009419:Nerve Tissue Proteins / Q000235:genetics; D009483:Neuropsychological Tests; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D010100:Oxygen / Q000097:blood; D020641:Polymorphism, Single Nucleotide; D015222:Sodium Channels / Q000235:genetics; D055815:Young Adult
chemical_list: D062550:NAV1.1 Voltage-Gated Sodium Channel; D009419:Nerve Tissue Proteins; C568242:SCN1A protein, human; D015222:Sodium Channels; D010100:Oxygen