title: The GIGYF2 variants are not associated with Parkinson's disease in the mainland Chinese population.
abstract: In order to determine the prevalence of GIGYF2 (Grb10-Interacting GYF Protein 2) variants in the Chinese population and to better understand the association between GIGYF2 and Parkinson's disease (PD), we conducted the genetic screening of GIGYF2 in the Chinese population. Twelve exonic variants were identified in 52 familial PD probands and 56 healthy controls. Non-synonymous point variants (Thr25Ala, Asn457Th and Pro460Th) were analyzed in 510 PD patients and 481 healthy controls of Chinese Han ethnicity. The insertion and deletion variants in Exon 25 (Ins Q 1212, Ins QQ 1217, Del Q 1210, Del Q 1216 and Del PPQ1217_1219) are not related to the onset of familial PD. Our data indicate the GIGYF2 variants are not associated with PD in the mainland Chinese Population.
authors.affiliation: Department of Neurology and Institute of Neurology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: L
authors.initials: L
authors.lastname: Cao
authors.forename: T
authors.initials: T
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Zheng
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: G
authors.initials: G
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: Q Z
authors.initials: QZ
authors.lastname: Fei
authors.forename: P J
authors.initials: PJ
authors.lastname: Cui
authors.forename: X J
authors.initials: XJ
authors.lastname: Wang
authors.forename: J F
authors.initials: JF
authors.lastname: Ma
authors.forename: Q
authors.initials: Q
authors.lastname: Xiao
authors.forename: S D
authors.initials: SD
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010300:Parkinson Disease / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D055815:Young Adult
chemical_list: D002352:Carrier Proteins; C478016:GIGYF2 protein, human