title: Computer-aided detection of breast carcinoma in standard mammographic projections with digital mammography.
abstract: OBJECTIVE
  A retrospective evaluation of the ability of computer-aided detection (CAD) ability to identify breast carcinoma in standard mammographic projections.
  
  
  METHODS
  Forty-five biopsy proven lesions in 44 patients imaged digitally with CAD applied at examination were reviewed. Forty-four screening BIRADS category 1 digital mammography examinations were randomly identified to serve as a comparative normal/control population. Data included patient age; BIRADS breast density; lesion type, size, and visibility; number, type, and location of CAD marks per image; CAD ability to mark lesions; needle core and surgical pathologic correlation.
  
  
  RESULTS
  The CAD lesion/case sensitivity of 87% (n = 39), image sensitivity of 69% (n = 31) for mediolateral oblique view and 78% (n = 35) for the craniocaudal view was found. The average false positive rate in 44 normal screening cases was 2.0 (range 1-8). The 2.0 figure is based on 88 reported false positive CAD marks in 44 normal screening exams: 98% (n = 44) lesions proceeded to excision; initial pathology upgraded at surgical excision from in situ to invasive disease in 24% (n = 9) lesions.
  
  
  CONCLUSIONS
  CAD demonstrated potential to detect mammographically visible cancers in standard projections for all lesion types.
authors.affiliation: Elizabeth Wende Breast Care, LLC, Rochester, NY, USA. sdestounis@ewbc.com
authors.forename: Stamatia
authors.initials: S
authors.lastname: Destounis
authors.forename: Sarah
authors.initials: S
authors.lastname: Hanson
authors.forename: Renee
authors.initials: R
authors.lastname: Morgan
authors.forename: Philip
authors.initials: P
authors.lastname: Murphy
authors.forename: Patricia
authors.initials: P
authors.lastname: Somerville
authors.forename: Posy
authors.initials: P
authors.lastname: Seifert
authors.forename: Valerie
authors.initials: V
authors.lastname: Andolina
authors.forename: Andrea
authors.initials: A
authors.lastname: Arieno
authors.forename: Melissa
authors.initials: M
authors.lastname: Skolny
authors.forename: Wende
authors.initials: W
authors.lastname: Logan-Young
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D002277:Carcinoma / Q000000981:diagnostic imaging*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity