Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook.
BACKGROUND
In this commentary we present the findings from an international consortium on fish toxicogenomics sponsored by the U.K. Natural Environment Research Council (Fish Toxicogenomics-Moving into Regulation and Monitoring, held 21-23 April 2008 at the Pacific Environmental Science Centre, Vancouver, BC, Canada).


OBJECTIVE
The consortium from government agencies, academia, and industry addressed three topics: progress in ecotoxicogenomics, regulatory perspectives on roadblocks for practical implementation of toxicogenomics into risk assessment, and dealing with variability in data sets.


CONCLUSIONS
Participants noted that examples of successful application of omic technologies have been identified, but critical studies are needed to relate molecular changes to ecological adverse outcome. Participants made recommendations for the management of technical and biological variation. They also stressed the need for enhanced interdisciplinary training and communication as well as considerable investment into the generation and curation of appropriate reference omic data.


CONCLUSIONS
The participants concluded that, although there are hurdles to pass on the road to regulatory acceptance, omics technologies are already useful for elucidating modes of action of toxicants and can contribute to the risk assessment process as part of a weight-of-evidence approach.
Van Aggelen
Graham
G
Environment Canada, Pacific Environmental Science Centre, British Columbia, Canada.
Ankley
Gerald T
GT
Baldwin
William S
WS
Bearden
Daniel W
DW
Benson
William H
WH
Chipman
J Kevin
JK
Collette
Tim W
TW
Craft
John A
JA
Denslow
Nancy D
ND
Embry
Michael R
MR
Falciani
Francesco
F
George
Stephen G
SG
Helbing
Caren C
CC
Hoekstra
Paul F
PF
Iguchi
Taisen
T
Kagami
Yoshi
Y
Katsiadaki
Ioanna
I
Kille
Peter
P
Liu
Li
L
Lord
Peter G
PG
McIntyre
Terry
T
O'Neill
Anne
A
Osachoff
Heather
H
Perkins
Ed J
EJ
Santos
Eduarda M
EM
Skirrow
Rachel C
RC
Snape
Jason R
JR
Tyler
Charles R
CR
Versteeg
Don
D
Viant
Mark R
MR
Volz
David C
DC
Williams
Tim D
TD
Yu
Lorraine
L
D000818:Animals; D054750:Ecotoxicology / Q000331:legislation & jurisprudence / Q000639:trends; D004784:Environmental Monitoring / Q000331:legislation & jurisprudence; D005399:Fishes / Q000235:genetics; D007390:International Agencies; D018570:Risk Assessment; D043922:Toxicogenetics / Q000331:legislation & jurisprudence