Modelling of porosity and waterfronts in cellulosic pellets for understanding drug release behavior.
The microstructure of cellulose microcrystalline-Carbopol pellets, prepared under different drying conditions (oven-dried or freeze-dried), was experimentally characterized using mercury intrusion porosimetry and then computationally modelled using Pore-Cor software. Connectivity (mean number of throats per pore), pore skew (sigma), throat skew (q) and correlation level were estimated and simultaneously optimized from the mercury intrusion porosimetry cumulative curves using the Boltzmann-annealed simplex algorithm. Unit cells with percolation properties close to the real ones were generated. Water penetration rate in the simulated structures was also modelled using Pore-Cor and the waterfront position was calculated using the Bosanquet equation. A close correlation was found between the simulated water flow rate in the unit cell and the experimental theophylline first-order release rate constant. Thus, modelling of network microstructure and waterfronts appears as an useful tool for predicting drug release rate from matrix pellets.
Gomez-Carracedo
Ana
A
Departamento de Farmacia y Tecnologia Farmaceutica, Universidad de Santiago de Compostela, Santiago de Compostela 15782, Spain.
Martinez-Pacheco
Ramon
R
Concheiro
Angel
A
Gomez-Amoza
Jose Luis
JL
D000179:Acrylates / Q000737:chemistry; D000465:Algorithms; D002482:Cellulose / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003890:Desiccation / Q000379:methods; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry*; D005612:Freeze Drying; D008956:Models, Chemical; D016062:Porosity; D013806:Theophylline / Q000008:administration & dosage / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D000179:Acrylates; D005079:Excipients; C117167:carbopol 974P NF; D014867:Water; D002482:Cellulose; D013806:Theophylline; C109691:microcrystalline cellulose