Persistent low-grade inflammation and regular exercise.
Persistent low-grade systemic inflammation is a feature of chronic diseases such as cardiovascular disease (CVD), type 2 diabetes and dementia and evidence exists that inflammation is a causal factor in the development of insulin resistance and atherosclerosis. Regular exercise offers protection against all of these diseases and recent evidence suggests that the protective effect of exercise may to some extent be ascribed to an anti-inflammatory effect of regular exercise. Visceral adiposity contributes to systemic inflammation and is independently associated with the occurrence of CVD, type 2 diabetes and dementia. We suggest that the anti-inflammatory effects of exercise may be mediated via a long-term effect of exercise leading to a reduction in visceral fat mass and/or by induction of anti-inflammatory cytokines with each bout of exercise.
Astrom
Maj-Briit
MB
Department of Infectious Diseases and CMRC Copenhagen University Hospital, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, The Centre of Inflammation and Metabolism, Copenhagen, Denmark.
Feigh
Michael
M
Pedersen
Bente Klarlund
BK
D050197:Atherosclerosis / Q000209:etiology*; D016207:Cytokines / Q000097:blood; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000517:prevention & control*; D007333:Insulin Resistance / Q000502:physiology*; D050152:Intra-Abdominal Fat / Q000503:physiopathology*
D016207:Cytokines