title: Multicenter veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogs.
abstract: OBJECTIVE
  To assess the effect of food containing high concentrations of fish oil omega-3 fatty acids and a low omega-6-omega-3 fatty acid ratio on clinical signs of osteoarthritis in dogs.
  
  
  METHODS
  Randomized, double-blinded, controlled clinical trial.
  
  
  METHODS
  127 client-owned dogs with osteoarthritis in 1 or more joints from 18 privately owned veterinary clinics.
  
  
  METHODS
  Dogs were randomly assigned to be fed for 6 months with a typical commercial food or a test food containing a 31-fold increase in total omega-3 fatty acid content and a 34-fold decrease in omega-6-omega-3 ratio, compared with the control food. Dog owners completed a questionnaire about their dog's arthritic condition, and investigators performed a physical examination and collected samples for a CBC and serum biochemical analyses (including measurement of fatty acids concentration) at the onset of the study and at 6, 12, and 24 weeks afterward.
  
  
  RESULTS
  Dogs fed the test food had a significantly higher serum concentration of total omega-3 fatty acids and a significantly lower serum concentration of arachidonic acid at 6, 12, and 24 weeks. According to owners, dogs fed the test food had a significantly improved ability to rise from a resting position and play at 6 weeks and improved ability to walk at 12 and 24 weeks, compared with control dogs.
  
  
  CONCLUSIONS
  Ingestion of the test food raised blood concentrations of omega-3 fatty acids and appeared to improve the arthritic condition in pet dogs with osteoarthritis.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
authors.forename: James K
authors.initials: JK
authors.lastname: Roush
authors.forename: Chadwick E
authors.initials: CE
authors.lastname: Dodd
authors.forename: Dale A
authors.initials: DA
authors.lastname: Fritsch
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Allen
authors.forename: Dennis E
authors.initials: DE
authors.lastname: Jewell
authors.forename: William D
authors.initials: WD
authors.lastname: Schoenherr
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Richardson
authors.forename: Phillip S
authors.initials: PS
authors.lastname: Leventhal
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Hahn
mesh_terms: D000824:Animal Nutritional Physiological Phenomena / Q000502:physiology*; D000818:Animals; D004283:Dog Diseases / Q000097:blood / Q000178:diet therapy* / Q000473:pathology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage / Q000097:blood; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage / Q000737:chemistry; D005527:Food, Fortified; D008297:Male; D010003:Osteoarthritis / Q000097:blood / Q000178:diet therapy / Q000473:pathology / Q000662:veterinary*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005395:Fish Oils