title: Anti N1 cross-protecting antibodies against H5N1 detected in H1N1 infected people.
abstract: The A(H5N1) influenza virus pandemic may be the result of avian H5N1 adapting to humans, leading to massive human to human transmission in a context of a lack of pre-existing immunity. As A(H1N1) and A(H5N1) share the same neuraminidase subtype, anti-N1 antibodies subsequent to H1N1 infections or vaccinations may confer some protection against A(H5N1). We analysed, by microneutralization assay, the A/Vietnam/1194/04 (H5N1) anti-N1 cross-protection acquired either during A/New-Caledonia/20/99 (H1N1) infection or vaccination. In cases with documented H1N1 infection, H5N1 cross-protection could be observed only in patients born between 1930 and 1950. No such protection was detected in the sera of vaccinated individuals.
authors.affiliation: Laboratoire de Virologie, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, 59 boulevard Pinel, 69677, Bron Cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Frobert
authors.forename: M
authors.initials: M
authors.lastname: Bouscambert-Duchamp
authors.forename: V
authors.initials: V
authors.lastname: Escuret
authors.forename: S
authors.initials: S
authors.lastname: Mundweiler
authors.forename: M
authors.initials: M
authors.lastname: Barthélémy
authors.forename: F
authors.initials: F
authors.lastname: Morfin
authors.forename: M
authors.initials: M
authors.lastname: Valette
authors.forename: C
authors.initials: C
authors.lastname: Gerdil
authors.forename: B
authors.initials: B
authors.lastname: Lina
authors.forename: O
authors.initials: O
authors.lastname: Ferraris
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology; D057134:Antibodies, Neutralizing / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D056738:Cross Protection; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D053124:Influenza A Virus, H5N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology; D007251:Influenza, Human / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D008875:Middle Aged; D009439:Neuraminidase / Q000276:immunology*; D009500:Neutralization Tests; D014611:Vaccination; D055815:Young Adult
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D007252:Influenza Vaccines; D009439:Neuraminidase