title: Gastroesophageal reflux/laryngopharyngeal reflux disease:  a critical analysis of the literature.
abstract: Despite the wealth of publications on the topic of gastroesophageal reflux and its variants, there are still many unsettled questions before one accepts the prevalent cult of "reflux disease". This study is summarizing the results of the critical analysis of the literature, 436 articles,during the last 30 years. The golden test to identify the patient group suffering from this rather common phenomenon is still lacking. The claimed extra-esophageal manifestations especially in the larynx are non-specific and may be caused by other factors well-known within the domain of vocology. The response to therapeutic intervention still lacks serious well-controlled studies to allow drawing reasonable conclusions. An outstanding feature of the publications is that most of them fall in the category of "review". It seems that there is a tendency to perpetuate the concept without objective criticism. Following the analysis, a recommendation for anew plan of original well-controlled multi-center studies is highlighted.
authors.affiliation: Phoniatric Unit of the Otorhinolaryngology Department,Faculty of Medicine, Ain Shams University, Cairo, Egypt.nkotby@cng.com.eg
authors.forename: M N
authors.initials: MN
authors.lastname: Kotby
authors.forename: O
authors.initials: O
authors.lastname: Hassan
authors.forename: Aly M N
authors.initials: AM
authors.lastname: El-Makhzangy
authors.forename: M
authors.initials: M
authors.lastname: Farahat
authors.forename: M
authors.initials: M
authors.lastname: Shadi
authors.forename: P
authors.initials: P
authors.lastname: Milad
mesh_terms: D016099:Endoscopy, Gastrointestinal; D050782:Esophageal pH Monitoring; D005744:Gastric Acid / Q000378:metabolism; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D011379:Prognosis; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
chemical_list: D054328:Proton Pump Inhibitors