Synthesis and antitumor activities of phenanthrene-based alkaloids.
A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-L-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-L-valinol (9) exhibited good activities, with IC(50) values of 11.6 and 6.1 microM, respectively.
Li
Songtao
S
Department of Natural Products Chemistry, Pharmaceutical School, China Medical University, Shenyang 110001, China.
Han
Li
L
Sun
Liang
L
Zheng
Dan
D
Liu
Jiang
J
Fu
Yingbo
Y
Huang
Xueshi
X
Wang
Zhanyou
Z
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D010616:Phenanthrenes / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D000470:Alkaloids; D000970:Antineoplastic Agents; D010616:Phenanthrenes; C031181:phenanthrene