title: Effect of postprandial modulation of glucose availability: short- and long-term analysis.
abstract: Low glycaemic index (LGI) foods have been proposed as potential means to decrease postprandial glucose excursions and thus to improve diabetes management. We modulated glucose availability of cereal products and thus their glycaemic index to study the metabolic effect of LGI foods on daylong glucose control acutely and in the long term following a 5-week GI intervention diet in free-living subjects. In this randomised, parallel trial, two groups of nineteen overweight subjects followed an ad libitum 5-week intervention diet in which usual starch was replaced by either LGI or high GI (HGI) starch. During the exploration days (days 1 and 36), subjects ate their assigned 13C-labelled test breakfast (LGI or HGI), and total and exogenous glucose kinetics (using stable isotopes), postprandial concentrations of glucose, insulin, lipid profile and nutrient oxidation were assessed after the test breakfast and a standardised lunch. At day 1, LGI breakfast significantly decreased post-breakfast glycaemic response with a parallel decrease in exogenous and total glucose appearance (P < 0.05). Post-lunch and post-breakfast glycaemic responses were positively correlated (r 0.79, P < 0.0001). Following the 5-week diet, difference between the groups in terms of glucose kinetics and response was maintained (no significant interaction group x time) but tended to decrease over time for the post-breakfast glycaemic response. Post-lunch and post-breakfast glycaemic responses remained positively correlated (r 0.47, P = 0.004). Modulation of postprandial glucose availability at breakfast decreased plasma exogenous glucose appearance and improved glucose control at the subsequent lunch. After 5 weeks, these effects were maintained in healthy subjects but remained to be confirmed in the longer term.
authors.affiliation: Centre de Recherche en Nutrition Humaine de Rhône-Alpes (CRNHRA), Pavillon médical, Centre hospitalier Lyon Sud, 165 chemin du grand Revoyet, 69495 Pierre-Bénite, France.
authors.forename: Julie-Anne
authors.initials: JA
authors.lastname: Nazare
authors.forename: Alexis
authors.initials: A
authors.lastname: de Rougemont
authors.forename: Sylvie
authors.initials: S
authors.lastname: Normand
authors.forename: Valérie
authors.initials: V
authors.lastname: Sauvinet
authors.forename: Monique
authors.initials: M
authors.lastname: Sothier
authors.forename: Sophie
authors.initials: S
authors.lastname: Vinoy
authors.forename: Michel
authors.initials: M
authors.lastname: Désage
authors.forename: Martine
authors.initials: M
authors.lastname: Laville
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001682:Biological Availability; D001786:Blood Glucose; D005260:Female; D005504:Food Analysis; D005947:Glucose / Q000493:pharmacokinetics*; D038321:Glycemic Index; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D050177:Overweight; D019518:Postprandial Period; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D005947:Glucose