title: Estimating time to steady state using the effective rate of drug accumulation.
abstract: Unless all of a drug is eliminated during each dosing interval, the plasma concentrations within a dosing interval will increase until the time course of change in plasma concentrations becomes invariant from one dosing interval to the next, resulting in steady state. A simple method for estimating drug concentration time to steady state based on multiple dose area under the plasma concentration-time curve and effective rate of drug accumulation is presented. Several point estimates and confidence intervals for time to 90% of steady state are compared, and a recommendation is made on how to summarize and present the results.
authors.affiliation: Merck Research Laboratories, Clinical Pharmacology Statistics, North Wales, PA 19454-1099, USA. Deborah_panebianco@merck.com
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Panebianco
authors.forename: Andrea
authors.initials: A
authors.lastname: Maes
mesh_terms: D019540:Area Under Curve; D015233:Models, Statistical; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010949:Plasma / Q000378:metabolism*; D013997:Time Factors
chemical_list: D004364:Pharmaceutical Preparations