title: [A case of super advanced gastric cancer responding to S-1+CDDP and S-1 single regimen which led to a clinical complete response].
abstract: A patient is a 62-year-old man who was presented by epigastralgia. He was pointed out super advanced gastric cancer with paraaortic lymph node metastasis and pancreatic invasion by gastrointestinal endoscopy (GIS) and computed tomography (CT). We diagnosed as cT4N3M0, and started with chemotherapy as follows. S-1 (120 mg/day) was orally administered for 3 weeks followed by 2-week rest as one course, and CDDP (90 mg/body)was administered by intravenous drip on day 8. Partial response was indicated after 6 courses of this procedure. We changed the procedure to S-1 single treatment for 2 weeks followed by 2-week rest. After 12-course of this procedure, he was attacked by brain infarction, the procedure was interrupted for about 8 months. After rehabilitation, an S-1 single treatment was restarted. The main tumor and metastatic lymph node appeared no change before the interruption of S-1 single treatment. So, we considered that complete response was continued. S-1+CDDP and S-1 single regimen appears to be effective for super advanced gastric cancer.
authors.affiliation: Department of Surgery, Kinki Central Hospital of Mutual Aid Association of Public School Teachers.
authors.forename: Taro
authors.initials: T
authors.lastname: Aoki
authors.forename: Yuko
authors.initials: Y
authors.lastname: Igarashi
authors.forename: Keiko
authors.initials: K
authors.lastname: Tanizaki
authors.forename: Chihiro
authors.initials: C
authors.lastname: Yamanaka
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Tanida
authors.forename: Takamichi
authors.initials: T
authors.lastname: Komori
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Kiyonori
authors.initials: K
authors.lastname: Nishioka
authors.forename: Ko
authors.initials: K
authors.lastname: Takachi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Uemura
authors.forename: Kenji
authors.initials: K
authors.lastname: Kobayashi
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D006801:Humans; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy*; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin