Aporphine and bisaporphine alkaloids from Aristolochia lagesiana var. intermedia.
Corydines, isocorydines, and analogous aporphine alkaloids were isolated from the leaves of Aristolochia lagesiana var. intermedia, together with three bisaporphine salts (lagesianines B-D). Their structures were determined by chemical derivatizations and spectroscopic analyses. Lagesianines B and C are the first examples of N-CH(2)-N' and C-2-O-C-1' linked dimeric aporphine alkaloids, respectively, while the monomeric units of lagesianine D, which has a carbon skeleton, are linked through C-7-C-5'via an ethane-1,2-diol group (C-7-CHOHCHOH-C-5').
Ferreira
Marcia L R
ML
Instituto de Química, São Paulo State University, UNESP, C.P. 355, 14801-970 Araraquara, SP, Brazil.
de Pascoli
Inara C
IC
Nascimento
Isabele R
IR
Zukerman-Schpector
Julio
J
Lopes
Lucia M X
LM
D001060:Aporphines / Q000737:chemistry* / Q000302:isolation & purification*; D030022:Aristolochia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy
D001060:Aporphines; C081279:aporphine