title: Significant association of ERCC6 single nucleotide polymorphisms with bladder cancer susceptibility in Taiwan.
abstract: OBJECTIVE
  To evaluate the association between the polymorphisms of the ERCC6 DNA repair gene, which plays an important role in maintaining genome stability, and the risk of bladder cancer in Taiwan.
  
  
  METHODS
  In this hospital-based case-control study, the association of ERCC6 codon 399, 1097 and 1413 polymorphisms with bladder cancer risk in a Central Taiwanese population was first investigated. In total, 288 patients with bladder cancer and 288 age- and gender-matched healthy controls recruited from the China Medical Hospital in Taiwan were genotyped.
  
  
  RESULTS
  A significantly different distribution was found in the frequency of the ERCC6 codon 399 genotypes, but not the ERCC6 codon 1097 or 1413 genotypes, between the bladder cancer and control groups. Those who had homozygous A/A or heterozygous A/G at ERCC6 codon 399 showed a 1.97- and 1.04-fold (95% confidence interval=1.29-3.01 and 0.71-1.53, respectively) increased risk of bladder cancer compared to those with G/G. As for ERCC6 codon 1097 or 1413, there was no difference in distribution between the bladder cancer and control groups.
  
  
  CONCLUSIONS
  The first evidence that the homozygous A allele of the ERCC6 codon 399 may be associated with the development of bladder cancer and may be a novel useful marker for primary prevention and anticancer intervention is provided.
authors.affiliation: Terry Fox Cancer Research Laboratory, China Medical University Hospital, 2 Yuh-Der Road, Taichung, 404 Taiwan, R.O.C.
authors.forename: Chao-Hsiang
authors.initials: CH
authors.lastname: Chang
authors.forename: Chang-Fang
authors.initials: CF
authors.lastname: Chiu
authors.forename: Hwei-Chung
authors.initials: HC
authors.lastname: Wang
authors.forename: Hsi-Chin
authors.initials: HC
authors.lastname: Wu
authors.forename: Ru-Yin
authors.initials: RY
authors.lastname: Tsai
authors.forename: Chia-Wen
authors.initials: CW
authors.lastname: Tsai
authors.forename: Rou-Fen
authors.initials: RF
authors.lastname: Wang
authors.forename: Chung-Hsing
authors.initials: CH
authors.lastname: Wang
authors.forename: Yung-An
authors.initials: YA
authors.lastname: Tsou
authors.forename: Da-Tian
authors.initials: DT
authors.lastname: Bau
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D004265:DNA Helicases / Q000235:genetics*; D045643:DNA Repair Enzymes / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009367:Neoplasm Staging; D000075223:Poly-ADP-Ribose Binding Proteins; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D013624:Taiwan; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D000075223:Poly-ADP-Ribose Binding Proteins; D004265:DNA Helicases; C078673:ERCC6 protein, human; D045643:DNA Repair Enzymes