title: [Marburg I polymorphism of Factor VII-activating protease and cerebral infarction].
abstract: OBJECTIVE
  To determine the relation between Marburg I polymorphism of Factor VII-activating protease (FSAP) and cerebral infarction,and to analyze whether it is one of the risk factors of cerebral infarction.
  
  
  METHODS
  Single strand conformation polymorphism-polymerase chain reaction (SSCP-PCR) was applied for the polymorphism analysis of FSAP in 159 patients with cerebral infarction and 179 non-cerebral infarction subjects.
  
  
  RESULTS
  The phenotypes of FSAP in both the patients and the control subjects were wild type GG; no mutant of Marburg I was found. But a new gene mutation was tested, which had not been reported, requiring further investigation.
  
  
  CONCLUSIONS
  Marburg I polymorphism of FSAP may not be associated with cerebral infarction.
authors.affiliation: Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Tan
authors.forename: Huarong
authors.initials: H
authors.lastname: Tang
authors.forename: Rongrong
authors.initials: R
authors.lastname: Liu
authors.forename: Guangping
authors.initials: G
authors.lastname: Wang
authors.forename: Xiaosu
authors.initials: X
authors.lastname: Yang
authors.forename: Fangping
authors.initials: F
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D002544:Cerebral Infarction / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D017354:Point Mutation; D016133:Polymerase Chain Reaction / Q000379:methods; D018807:Polymorphism, Single-Stranded Conformational; D012307:Risk Factors; D012697:Serine Endopeptidases / Q000235:genetics*; D055815:Young Adult
chemical_list: C433550:HABP2 protein, human; D012697:Serine Endopeptidases