title: Experience-dependent alterations in conscious resting state activity following perceptuomotor learning.
abstract: In monkeys and rats, neural activity patterns during learning are reactivated during subsequent periods of rest or sleep. According to the reactivation-consolidation account, this process underlies the consolidation of memories. Brain imaging studies have extended these findings to humans during sleep, but not yet, during rest. Here, we show that learning-related reactivation also occurs in humans during rest. During functional MRI-scanning, participants trained on a perceptuomotor task flanked by rest periods. During training, we found robust activity in the superior parietal cortex. During post-training rest, this same area reactivated. We also found a link between parietal reactivation and learning. Activity in superior parietal cortex was associated with learning during training, and a control group that did not train on the perceptuomotor task did not show any difference between the pre- and post-training rest blocks in this region. These findings indicate that, during rest, reactivation also occurs in humans. This process may contribute to consolidation of perceptuomotor memories.
authors.affiliation: University of Amsterdam, Cognitive and Systems Neuroscience, Center for Neuroscience, Swammerdam Institute for Life Sciences, Faculty of Science, The Netherlands. s.m.daselaar@uva.nl
authors.forename: S M
authors.initials: SM
authors.lastname: Daselaar
authors.forename: W
authors.initials: W
authors.lastname: Huijbers
authors.forename: M
authors.initials: M
authors.lastname: de Jonge
authors.forename: P M
authors.initials: PM
authors.lastname: Goltstein
authors.forename: C M A
authors.initials: CM
authors.lastname: Pennartz
mesh_terms: D000328:Adult; D000818:Animals; D003243:Consciousness / Q000502:physiology*; D005260:Female; D005403:Fixation, Ocular / Q000502:physiology; D000882:Haplorhini; D006801:Humans; D007858:Learning; D008279:Magnetic Resonance Imaging; D008297:Male; D009039:Motion Perception; D010296:Parietal Lobe / Q000502:physiology*; D051381:Rats; D012146:Rest; D012890:Sleep; D055815:Young Adult