Generation of 500-member library of 10-alkyl-2-R(1),3-R(2)-4,10-dihydrobenzo[4,5]imidazo[1,2-alpha]pyrimidin-4-ones.
Representative benzimidazopyrimidinones were previously reported to be intercalating antitumor agents. In this work, we used 2-substituted 4,10-dihydrobenzo [4,5]imidazo[1,2-alpha]pyrimidin-4-ones for their diversification by regioselective alkylation. Under the conditions established, the alkylation gave 10-alkyl derivatives which permitted the parallel generation of a 500-member library of the title compounds.
Sirko
Svetlana M
SM
Department of Chemistry of Heterocyclic Compounds, SSI Institute for Single Crystals of National Academy of Sciences of Ukraine, Lenin Ave. 60, Kharkiv 61001, Ukraine.
Gorobets
Nikolay Yu
NY
Musatov
Vladimir I
VI
Desenko
Sergey M
SM
D000478:Alkylation; D000970:Antineoplastic Agents / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011744:Pyrimidinones / Q000737:chemistry*
D000970:Antineoplastic Agents; D011744:Pyrimidinones