[Early diagnostic biomarker for Alzheimer's disease now and in the future].
Alzheimer's disease is thought to be "common disease". It is expected that new biological diagnostic marker will be discovered for Alzheimer's disease. There are two roles in diagnostic biomarker for AD.: one is a screening and the other one is to help definite diagnosis for AD. Simple screening method using touch panel type computer (Forgetfulness consultation program) is most useful of screening tools and phosphorylated tau protein in cerebrospinal fluid is highly appreciated as a diagnostic biomarker to help definite diagnosis. Serum WGA binding transferrin in AD is significantly higher than that in controls and high levels of it proceed increased levels of amyloid beta protein. Serum WGA binding transferrin may be useful for early diagnostic biomarker in serum.
Urakami
Katsuya
K
Department of Biological Regulation, Faculty of Medicine, Tottori University.
Taniguchi
Miyoko
M
D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000097:blood; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D006801:Humans; D009483:Neuropsychological Tests; D014168:Transferrin; D016875:tau Proteins / Q000134:cerebrospinal fluid*
D016229:Amyloid beta-Peptides; D015415:Biomarkers; D014168:Transferrin; D016875:tau Proteins