Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice.
BACKGROUND
Disruption of the elastic lamina, as an early indicator of aneurysm formation, and vascular calcification frequently occur together in atherosclerotic lesions of humans.


RESULTS
We now report evidence of shared genetic basis for disruption of the elastic lamina (medial disruption) and medial calcification in an F(2) mouse intercross between C57BL/6J and C3H/HeJ on a hyperlipidemic apolipoprotein E (ApoE(-/-)) null


BACKGROUND
gene, known to mediate myocardial calcification. Using transgenic complementation, we show that Abcc6 also contributes to aortic medial calcification.


CONCLUSIONS
Our data indicate that calcification, though possibly contributory, does not always lead to medial disruption and that in addition to aneurysm formation, medial disruption may be the precursor to calcification.
Wang
Susanna S
SS
Department of Human Genetics, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Martin
Lisa J
LJ
Schadt
Eric E
EE
Meng
Haijin
H
Wang
Xuping
X
Zhao
Wei
W
Ingram-Drake
Leslie
L
Nebohacova
Martina
M
Mehrabian
Margarete
M
Drake
Thomas A
TA
Lusis
Aldons J
AJ
D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000473:pathology; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism; D050197:Atherosclerosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D002114:Calcinosis; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D040641:Quantitative Trait Loci
D018528:ATP-Binding Cassette Transporters; D001057:Apolipoproteins E; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C504743:Abcc6 protein, mouse