Recent advances in molecular imaging biomarkers in cancer: application of bench to bedside technologies.
Molecular imaging is the visualization, characterization and measurement of biological processes at the molecular and cellular level. In oncology, molecular imaging approaches can be directly applied as translational biomarkers of disease progression. In this article, selected imaging modalities are discussed with respect to this role. Recent studies focusing on emerging imaging biomarkers and new developments in the field are highlighted. Importantly, because ex vivo or tissue-based imaging now represents an important tool in the discovery and validation of oncology biomarkers, special attention is given to this resurgent field.
van der Meel
Roy
R
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands.
Gallagher
William M
WM
Oliveira
Sabrina
S
O'Connor
Aisling E
AE
Schiffelers
Raymond M
RM
Byrne
Annette T
AT
D000818:Animals; D014408:Biomarkers, Tumor; D018450:Disease Progression; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D011877:Radionuclide Imaging; D057170:Translational Research, Biomedical / Q000379:methods*; D054928:Validation Studies as Topic
D014408:Biomarkers, Tumor