Genetic association studies in patients with traumatic brain injury.
Traumatic brain injury (TBI) constitutes a major cause of mortality and disability worldwide, especially among young individuals. It is estimated that despite all the recent advances in the management of TBI, approximately half of the patients suffering head injuries still have unfavorable outcomes, which represents a substantial health care, social, and economic burden to societies. Considerable variability exists in the clinical outcome after TBI, which is only partially explained by known factors. Accumulating evidence has implicated various genetic elements in the pathophysiology of brain trauma. The extent of brain injury after TBI seems to be modulated to some degree by genetic variants. The authors' current review focuses on the up-to-date state of knowledge regarding genetic association studies in patients sustaining TBI, with particular emphasis on the mechanisms underlying the implication of genes in the pathophysiology of TBI.
Dardiotis
Efthimios
E
Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece. edar@med.uth.gr
Fountas
Kostas N
KN
Dardioti
Maria
M
Xiromerisiou
Georgia
G
Kapsalaki
Eftychia
E
Tasiou
Anastasia
A
Hadjigeorgiou
Georgios M
GM
D001057:Apolipoproteins E / Q000235:genetics; D001930:Brain Injuries / Q000235:genetics* / Q000401:mortality / Q000503:physiopathology; D006259:Craniocerebral Trauma / Q000503:physiopathology; D016158:Genes, p53 / Q000235:genetics; D056726:Genetic Association Studies / Q000379:methods* / Q000706:statistics & numerical data; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D015260:Neprilysin / Q000235:genetics; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011110:Polymorphism, Genetic
D001057:Apolipoproteins E; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A; D015260:Neprilysin