title: A convenient synthesis of nucleoside diphosphate glycopyranoses and other polyphosphorylated bioconjugates.
abstract: In this review, we summarize results obtained using a conceptionally new chemical synthesis of NDP-sugars based on cycloSaligenyl (cycloSal) nucleotides as starting material (cycloSal technique). The cycloSal technique not only leads to stereoisomerically defined NDP-sugars in high yield, but the same principle provides very efficient routes towards nucleoside di- and -triphosphates. Moreover, sugar-nucleotides such as CMP-Neu5Ac and dinucleoside polyphosphates are available. Thus, the method offers a nearly universal chemical access towards a large number of highly interesting bioconjugates and biomolecules.
authors.affiliation: Institute of Organic Chemistry, Department of Chemistry, Faculty of Sciences, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany.
authors.forename: Saskia
authors.initials: S
authors.lastname: Wolf
authors.forename: Tanja
authors.initials: T
authors.lastname: Zismann
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lunau
authors.forename: Svenja
authors.initials: S
authors.lastname: Warnecke
authors.forename: Silke
authors.initials: S
authors.lastname: Wendicke
authors.forename: Chris
authors.initials: C
authors.lastname: Meier
mesh_terms: D001671:Biochemistry / Q000379:methods*; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry; D009702:Nucleoside Diphosphate Sugars / Q000138:chemical synthesis* / Q000737:chemistry; D010766:Phosphorylation
chemical_list: D006001:Glycoconjugates; D009702:Nucleoside Diphosphate Sugars