Synthesis of triazolothiazolidinone derivatives of coumarin with antimicrobial activity.
A series of 2-(substituted phenyl)-3-[3-(2-oxo-2H-chromen-3-yl)-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-1,3-thiazolidin-4-ones, 8a-n, were synthesized and evaluated for their antimicrobial activity. The structures of the compounds were confirmed on the basis of their elemental analysis and spectral data. Compounds 8k, 81 and 8m showed significant inhibition against S. aureus, compound 8m showed significant inhibition against E. coli and compounds 8b, 8e, 8i, 8j, 8k, 81 and 8m showed significant inhibition against C. albicans.
Bhat
Mashooq A
MA
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Khartoum College of Medical Science, Aljerief West, 1st Block Number 398, P.O. Box 10995, Khartoum, Sudan. mashooqbhat@rediffmail.com
Siddiqui
Nadeem
N
Khan
Suroor A
SA
Mohamed
Mohamed Ibrahim
MI
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000890:Anti-Infective Agents; D003374:Coumarins; D053778:Thiazolidines; D014230:Triazoles