title: Hypotensive effect of juxtascleral administration of anecortave acetate in different types of glaucoma.
abstract: OBJECTIVE
  To evaluate the intraocular pressure (IOP)-lowering effect of anecortave acetate, delivered by anterior juxtascleral depot injection, in eyes with various forms of glaucoma.
  
  
  METHODS
  A prospective, interventional case series was carried out. Twenty-eight uncontrolled glaucoma patients received a single injection of anecortave acetate (24 to 30 mg) in 1 selected eye under topical anesthesia. Postinjection assessments were scheduled at week 1 and months 1, 2, and 3.
  
  
  RESULTS
  Mean ± SD age of patients was 58.2 ± 18.6 years. Twelve patients had open-angle glaucoma and 16 had angle-closure glaucoma. Uveitic/steroid-induced glaucoma was the most frequent diagnosis (11 patients, 39.2%). Mean baseline IOP was 30.7 ± 9.3 mm Hg. Mean IOP at week 1 and months 1, 2, and 3 were 21.3 ± 6.1, 19.8 ± 6.3, 20.9 ± 7.3, and 21.7 ± 6.8 mm Hg, respectively. Significant mean IOP reductions were observed at week 1 and months 1, 2, and 3 (29.3%, 33.8%, 30.1%, and 27.2%, respectively; P<0.001).
  
  
  CONCLUSIONS
  A single administration of anecortave acetate by anterior juxtascleral depot injection seems to result in a significant IOP reduction (compared with baseline) for at least 3 months in eyes with different types of glaucoma. No injection-related or drug-related serious adverse events were observed. Additional studies are required to better determine the efficacy, safety, and mechanism of action of this alternative treatment.
authors.affiliation: Vision Institute, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Tiago Santos
authors.initials: TS
authors.lastname: Prata
authors.forename: Ivan Maynart
authors.initials: IM
authors.lastname: Tavares
authors.forename: Paulo Augusto
authors.initials: PA
authors.lastname: Mello
authors.forename: Caroline
authors.initials: C
authors.lastname: Tamura
authors.forename: Verônica Castro
authors.initials: VC
authors.lastname: Lima
authors.forename: Rubens
authors.initials: R
authors.lastname: Belfort
mesh_terms: D000368:Aged; D000869:Anterior Eye Segment; D003692:Delayed-Action Preparations; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000188:drug therapy* / Q000503:physiopathology; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007267:Injections; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011244:Pregnadienediols / Q000008:administration & dosage*; D011446:Prospective Studies; D012590:Sclera; D014065:Tonometry, Ocular; D014792:Visual Acuity
chemical_list: D003692:Delayed-Action Preparations; D005938:Glucocorticoids; D011244:Pregnadienediols; C418047:anecortave acetate