[Indoleamine 2,3-dioxygenase activity during chemotherapy in patients with breast cancer].
We evaluated the significance of indoleamine 2, 3-dioxygenase (IDO) in recurrent breast cancer during chemotherapy. IDO activity can be measured by tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured by high performance liquid chromatography (HPLC). The correlations among age and Trp/Kyn ratio or immunosuppressive acidic protein (IAP) value in pre-chemotherapies or post-chemotherapies were studied. In under 35-year-old patients, there were no correlations between pre-chemotherapy and post-chemotherapy in IAP values and Trp/Kyn ratio. But in over 36-year-old patients, both Trp/Kyn ratio and IAP value in post-chemotherapy were higher than in pre-chemotherapy. These results suggest that the immunological damages for the patients during chemotherapy may depend on the age of patients.
Sakurai
Kenichi
K
Division of Breast and Endocrine Surgery, Department of Surgery, Nihon University School of Medicine.
Matsuo
Sadanori
S
Enomoto
Katsuhisa
K
Tani
Mayumi
M
Kitajima
Akira
A
Amano
Sadao
S
D000328:Adult; D000367:Age Factors; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000201:enzymology*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000097:blood*; D007737:Kynurenine / Q000097:blood; D008875:Middle Aged; D014364:Tryptophan / Q000097:blood
D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007737:Kynurenine; D014364:Tryptophan