title: G-protein beta3 Subunit Gene 825C/T Polymorphism Is Not Associated with Olanzapine-Induced Weight Gain in Korean Schizophrenic Patients.
abstract: OBJECTIVE
  Weight gain is a possible adverse effect of the use of antipsychotics, and is an important factor for long-term health and treatment compliance. Olanzapine is an atypical antipsychotic known to cause considerable weight gain. A relationship between weight gain and the G protein beta3 subunit gene (GNB3) 825C/T polymorphism has been reported. We therefore examined this possible association in a Korean schizophrenic patient group receiving olanzapine treatment.
  
  
  METHODS
  Weight and height measurements were obtained prior to starting olanzapine and measured again after long-term treatment. Genotyping for the 825C/T polymorphism was performed using a PCR-based method.
  
  
  RESULTS
  We found that long-term treatment with olanzapine resulted in mean gains in weight and body mass index (BMI) of 5.2 kg and 1.93 kg/m(2), respectively. There was a no significant difference in the mean body weight change from baseline to the endpoint after olanzapine treatment between the genotype groups (p=0.796). There were also no significant differences in genotype or allele frequencies between the severe weight-gain (more than 10%) and minimal weight-gain (less than 10%) groups (chi(2)=0.037, p=0.98; chi(2)=0.020, p=0.89).
  
  
  CONCLUSIONS
  The finding from this study thus does not support a relationship between the GNB3 825C/T polymorphism and weight gain in Korean schizophrenic patients receiving olanzapine treatment.
authors.affiliation: Department of Psychiatry, Inje University College of Medicine, Goyang, Korea.
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Park
authors.forename: Young-Cho
authors.initials: YC
authors.lastname: Chung
authors.forename: Seung-Hwan
authors.initials: SH
authors.lastname: Lee
authors.forename: Kang-Joon
authors.initials: KJ
authors.lastname: Lee
authors.forename: Hyun
authors.initials: H
authors.lastname: Kim
authors.forename: Jung-Eun
authors.initials: JE
authors.lastname: Choi
authors.forename: Seung-Gul
authors.initials: SG
authors.lastname: Kang
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Lee
authors.forename: Leen
authors.initials: L
authors.lastname: Kim
authors.forename: Heon-Jeong
authors.initials: HJ
authors.lastname: Lee