[Human papillomaviruses in the pathogenesis of intraepithelial neoplasia (AIN) and carcinoma of the anus].
HPV infections have been implicated in the pathogenesis of anal cancers. The mode of infection and subsequent transformation resembles very much the pathogenesis of cervical and other HPV-associated cancers. The molecular dissection of individual steps required to achieve cellular transformation within an HPV-infected cell led to the identification of novel biomarkers that make it possible to identify HPV-transformed cells with substantially higher precision in comparison to conventional methods. Since effective antiretroviral therapy allows for possible long-term survival of HIV-infected individuals who are at very high risk to develop HPV-associated cancers in the anogenital tract, these new developments have become increasingly relevant for practicing dermatologists and proctologists. We here briefly review the basic concepts and some clinical applications of this recent research.
von Knebel Doeberitz
M
M
Abteilung für Angewandte Tumorbiologie, Institut für Pathologie, Universität Heidelberg, Heidelberg, Deutschland. knebel@med.uni-heidelberg.de
Reuschenbach
M
M
D001005:Anus Neoplasms / Q000473:pathology / Q000821:virology*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002278:Carcinoma in Situ / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000821:virology*; D011230:Precancerous Conditions / Q000473:pathology / Q000821:virology*
D014408:Biomarkers, Tumor