High seroprevalence of neutralizing capacity against human metapneumovirus in all age groups studied in Bonn, Germany.
Human metapneumovirus (hMPV) infections occur frequently despite high rates of perpetual seroprevalence for all age groups. Analyses of approximately 2,000 archived, randomly selected serum samples demonstrated that neutralizing capacities remain high, with a minor decrease for individuals over 69 years of age, leading to the hypothesis that reinfections occur because humoral immune responses play minor roles in the clearance of hMPV infections.
Lüsebrink
Jessica
J
Institute for Virology, University of Bonn Medical Centre, Bonn, Germany.
Wiese
Christoph
C
Thiel
Anne
A
Tillmann
Ramona-Liza
RL
Ditt
Vanessa
V
Müller
Andreas
A
Schildgen
Oliver
O
Schildgen
Verena
V
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D057134:Antibodies, Neutralizing / Q000097:blood / Q000276:immunology; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005858:Germany; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D029121:Metapneumovirus / Q000276:immunology; D008875:Middle Aged; D009500:Neutralization Tests; D018184:Paramyxoviridae Infections / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D016036:Seroepidemiologic Studies; D055815:Young Adult
D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral