title: Dietary iron intake and risk of endometrial cancer: a population-based case-control study in Shanghai, China.
abstract: Dietary red meat and animal fat have been linked to endometrial cancer (EC) risk, but the impact of bioavailable iron in animal-derived foods has been less well studied. Our objective was to investigate the effects of iron and fats on the risk of EC in a large, population-based, case-control study. The Shanghai Endometrial Cancer Study enrolled 1,204 EC cases and 1,212 controls who completed in-person interviews, including a food frequency questionnaire. Animal-derived iron and fat intakes were calculated from dietary intakes and food composition tables. Logistic regression models were used to evaluate independent and joint effects of iron and fat on EC risk. Animal-derived iron intake was positively associated with EC risk [adjusted OR = 1.9; 95% CI = 1.4-2.7, P(trend) < 0.01, highest vs. lowest quartile], predominantly after menopause (OR = 2.2; 95%CI = 1.4-3.4, P(trend) < 0.01) and in women with BMI >or= 25 kg/m(2)(OR = 3.2; 95% CI = 1.4-7.5 in postmenopausal obese women, P(trend) < 0.01). Animal-derived fat was also associated with postmenopausal EC risk (OR = 1.7; 95% CI = 1.2-2.5, P(trend) < 0.01). Multiplicative interactions between animal-derived iron and BMI or animal-derived fat intake were not observed. Animal-derived iron intake is associated with increased risk of EC after menopause and among obese women. Avoidance of animal-derived (heme) iron may reduce the risk of EC in these women.
authors.affiliation: Institute for Medicine and Public Health, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA. asha.kallianpur@vanderbilt.edu
authors.forename: Asha R
authors.initials: AR
authors.lastname: Kallianpur
authors.forename: Sang-Ah
authors.initials: SA
authors.lastname: Lee
authors.forename: Wang-Hong
authors.initials: WH
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
authors.forename: Hui
authors.initials: H
authors.lastname: Cai
authors.forename: Zhi-Xian
authors.initials: ZX
authors.lastname: Ruan
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Xiang
authors.forename: Xiao Ou
authors.initials: XO
authors.lastname: Shu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000818:Animals; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004032:Diet; D015930:Diet Records; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006418:Heme / Q000737:chemistry; D006801:Humans; D019266:Iron, Dietary / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D016015:Logistic Models; D008460:Meat / Q000032:analysis; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D016017:Odds Ratio; D017698:Postmenopause; D012307:Risk Factors
chemical_list: D004041:Dietary Fats; D019266:Iron, Dietary; D006418:Heme