Severity of bronchopulmonary dysplasia and increased risk of feeding desaturation and growth delay in very low birth weight preterm infants.
Oral feeding has been reported to compromise breathing among preterm infants with bronchopulmonary dysplasia (BPD) during hospitalization or shortly after discharge. However, limited information was available concerning whether preterm infants with BPD remain vulnerable to feeding and growth insufficiency after a longer term of follow-up. The purpose of this study was therefore to examine the effect of severity of BPD on pulse oxygen saturation (SpO(2)) during feeding and growth in very low birth weight (VLBW) preterm infants during infancy. Seventy-two preterm infants with VLBW and 15 term infants were prospectively examined their growth and SpO(2) during feeding at 2, 4, and 6 months of corrected age. The severity of BPD was graded in VLBW infants according to the American National Institutes of Health consensus definition. In comparison to VLBW infants with mild BPD and term infants, VLBW infants with severe BPD showed significantly lower mean levels of SpO(2) during feeding at 2-6 months corrected age (P < 0.05). Those with severe BPD further exhibited higher rates of growth delay (weight < 10th percentile) throughout the study period. Among VLBW infants, severe BPD had an adverse relation with subsequent weight measures after adjustment for medical and demographic confounding variables (beta = -904 g, P = 0.03). The consensus BPD definition is useful to identify those preterm infants who are at greater risk of feeding desaturation and growth delay during infancy and close monitoring of SpO(2) during feeding should be advised.
Wang
Li-Ying
LY
School and Graduate Institute of Physical Therapy, National Taiwan University College of Medicine, Taipei, Taiwan.
Luo
Hong-Ji
HJ
Hsieh
Wu-Shiun
WS
Hsu
Chyong-Hsin
CH
Hsu
Hui-Chin
HC
Chen
Pei-Shan
PS
Chiu
Nan-Chang
NC
Lee
Wang-Tso
WT
Jeng
Suh-Fang
SF
D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology*; D002657:Child Development; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007228:Infant Nutrition Disorders / Q000453:epidemiology*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D019102:Infant, Very Low Birth Weight / Q000254:growth & development*; D008137:Longitudinal Studies; D008297:Male; D010100:Oxygen / Q000097:blood; D012306:Risk
D010100:Oxygen