title: [Evaluation of D-dimer in outpatients: clinical value and specific features].
abstract: D-dimer as an activation marker of coagulation and fibrinolysis is a recognized diagnostic criterion of deep vein thrombosis, pulmonary thromboembolism, and disseminated intravascular coagulation. In recent years, this laboratory test has been most frequently used for other purposes: to detect the activation of coagulation, to predict the course of diseases, and to determine the duration of anticoagulant therapy. Our investigation examined 1514 D-dimer measurements in 1370 outpatients without acute abnormalities, including 72 patients receiving warfarin and 32 patients after myocardial revascularization. 36.1% of cases were found to have values of more than 0.5 mkg/ml. Adequate anticoagulant therapy (INR 2-3) caused a reduction in the level of D-dimer that is an important additional laboratory test for the evaluation of antithrombotic defense. Further investigations are needed to determine cutoff values for various clinical situations.
authors.forename: T V
authors.initials: TV
authors.lastname: Vavilova
authors.forename: Iu K
authors.initials: IuK
authors.lastname: Vorob'eva
authors.forename: I G
authors.initials: IG
authors.lastname: Krupotkina
authors.forename: M M
authors.initials: MM
authors.lastname: Mnuskina
authors.forename: E A
authors.initials: EA
authors.lastname: Zherlitsina
authors.forename: S R
authors.initials: SR
authors.lastname: Minkin
mesh_terms: D000553:Ambulatory Care / Q000379:methods; D000925:Anticoagulants / Q000627:therapeutic use; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000188:drug therapy; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D008297:Male; D010045:Outpatients; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D014859:Warfarin