title: Fibroadenoma and phyllodes tumors of anogenital mammary-like glands: a series of 13 neoplasms in 12 cases, including mammary-type juvenile fibroadenoma, fibroadenoma with lactation changes, and neurofibromatosis-associated pseudoangiomatous stromal hyperplasia with multinucleated giant cells.
abstract: The authors present a series of 13 fibroepithelial neoplasms involving anogenital mammary-like glands, all occurring in 12 female patients, whose age at diagnosis ranged from 30 to 51 years (mean, 38 y; median, 42 y). All women presented with a solitary asymptomatic nodule in the vulva (n=8), perineum (n=2), or near the anus (n=2) ranging in size from 1.5 to 4.5 cm. Microscopically, 8 lesions were classified as fibroadenoma, and 5, including 1 recurrent tumor, as phyllodes tumor, of which 1 was benign and 4 low-grade malignant. In addition to conventional findings, we describe several hitherto unreported features including juvenile fibroadenoma-like proliferation, fibroadenoma with lactation change, and pseudoangiomatous stromal hyperplasia with multinucleated stromal giant cells in a patient with neurofibromatosis, type 1 all constituting potential diagnostic pitfalls, which are best averted by using the same approach to diagnosis as for their analogous mammary counterparts.
authors.affiliation: Sikl's Department of Pathology, Charles University, Medical Faculty Hospital, Czech Republic. kazakov@medima.cz
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Kazakov
authors.forename: Dominic V
authors.initials: DV
authors.lastname: Spagnolo
authors.forename: Colin J
authors.initials: CJ
authors.lastname: Stewart
authors.forename: Jane
authors.initials: J
authors.lastname: Thompson
authors.forename: Abbas
authors.initials: A
authors.lastname: Agaimy
authors.forename: Gaetano
authors.initials: G
authors.lastname: Magro
authors.forename: Michele
authors.initials: M
authors.lastname: Bisceglia
authors.forename: Marina
authors.initials: M
authors.lastname: Vazmitel
authors.forename: Denisa
authors.initials: D
authors.lastname: Kacerovska
authors.forename: Heinz
authors.initials: H
authors.lastname: Kutzner
authors.forename: Petr
authors.initials: P
authors.lastname: Mukensnabl
authors.forename: Michal
authors.initials: M
authors.lastname: Michal
mesh_terms: D000328:Adult; D001005:Anus Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D005260:Female; D018226:Fibroadenoma / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D005833:Genital Neoplasms, Female / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D042361:Mammary Glands, Human / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000150:complications / Q000473:pathology; D003557:Phyllodes Tumor / Q000150:complications / Q000378:metabolism / Q000473:pathology*