The TAK1-TRAF6 signalling pathway.
Cellular responses to pathogens, growth factors, cytokines, extra- or intra-cellular stress, is a prerequisite for the cell to adapt to novel and potentially dangerous situations. If the changes in the extra- or intra-cellular milieu causes DNA-damage or revoke a signalling pathway utilized during morphogenesis, the epithelial cells might be forced to undergo programmed cell death (apoptosis) in the benefit for the whole organism or transform to a mesenchymal cell type (epithelial to mesenchymal transition; EMT), in respond to a specific stimuli. An overview is presented over the current knowledge for the key components in signal transduction in homeostasis, inflammation and cancer. A handful of transcription factors are crucial for the determination of the specific cellular responses, where the transforming growth factor-beta (TGF-beta) is an important factor as discussed in this review.
Landström
Marene
M
Rudbeck Laboratory, Department of Genetics and Pathology, Dag Hammarskjöld väg 20, Uppsala University, SE 751 24 Uppsala, Sweden. Marene.Landstrom@genpat.uu.se
D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D000818:Animals; D004789:Enzyme Activation; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D053583:Interleukin-1beta / Q000502:physiology; D020930:MAP Kinase Kinase Kinases / Q000737:chemistry / Q000502:physiology*; D020935:MAP Kinase Signaling System; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D015398:Signal Transduction; D051785:Smad Proteins / Q000378:metabolism; D048029:TNF Receptor-Associated Factor 6 / Q000737:chemistry / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology; D054875:Ubiquitination; D000099151:MAP Kinase Kinase Kinase 7
D048868:Adaptor Proteins, Signal Transducing; D053583:Interleukin-1beta; D020930:MAP Kinase Kinase Kinases; D018125:Receptors, Transforming Growth Factor beta; D051785:Smad Proteins; D048029:TNF Receptor-Associated Factor 6; D016212:Transforming Growth Factor beta; D000099151:MAP Kinase Kinase Kinase 7