title: [Amblyogenic factors in patients with an early-onset type of developmental glaucoma].
abstract: OBJECTIVE
  To extract amblyogenic factors in eyes with an early-onset type of developmental glaucoma despite good post-operative intraocular pressure (IOP) control.
  
  
  METHODS
  Subjects were 24 eyes of 14 patients that underwent successful trabeculotomy by 3 years of age and had their best-corrected visual acuity (BCVA) development monitored for at least 5 years or more after surgery. Principal factor analysis was performed on final logarithmic BCVA, age at operation, corneal diameter, corneal opacity, Haab's striae, spherical equivalent of final refractive error, final astigmatic degree, axial length, preoperative IOP, final vertical cup per disc ratio, and either presence or absence of eccentric fixation. Latent variables that had an eigenvalue of 1 or more underwent an orthogonal rotation with the varimax method in order to yield factor loadings of these 11 parameters.
  
  
  RESULTS
  The parameters that had absolute factor loading values of 0.6 or more in a latent variable including final BCVA were final BCVA, fixation status, refractive error, and Haab's striae. Two-variable comparisons also supported the significant association of the latter three parameters with final BCVA.
  
  
  CONCLUSIONS
  Amblyogenic factors in eyes with an early-onset type of developmental glaucoma were eccentric fixation, myopic refractive error, and the presence of Haab's striae.
authors.affiliation: Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan. manakamu@med.kobe-u.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakamura
authors.forename: Hiroko
authors.initials: H
authors.lastname: Shirabe
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Mizokami
authors.forename: Akira
authors.initials: A
authors.lastname: Negi
mesh_terms: D000293:Adolescent; D000550:Amblyopia; D002648:Child; D002675:Child, Preschool; D005163:Factor Analysis, Statistical; D005403:Fixation, Ocular; D005500:Follow-Up Studies; D005901:Glaucoma / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009216:Myopia; D014130:Trabeculectomy; D014792:Visual Acuity