Genistein up-regulates the iron efflux system in glial cells.
Astrocytes accumulate iron under chronic oxidative stress conditions in ageing and neurological disorders. The soybean isoflavone genistein possesses antioxidant properties and selective estrogen-like activities. Here, a possible role of genistein in modulation of iron transport was explored in glial cells. Genistein significantly increased iron export through estrogen receptor-beta-dependent p38 MAPK activation. Evidence is presented that this effect is associated to a p38 MAPK-triggered up-regulation of the iron export system made by ceruloplasmin and ferroportin-1, a pathway requiring activation of the transcription factor C/EBP.
Persichini
Tiziana
T
Department Biology, Università Roma Tre, 00146, Italy.
Maio
Nunziata
N
di Patti
Maria Carmela Bonaccorsi
MC
Rizzo
Gianluca
G
Colasanti
Marco
M
Musci
Giovanni
G
D022763:CCAAT-Enhancer-Binding Protein-alpha / Q000378:metabolism; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000378:metabolism; D027682:Cation Transport Proteins / Q000378:metabolism; D045744:Cell Line, Tumor; D002570:Ceruloplasmin / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000378:metabolism; D019833:Genistein / Q000494:pharmacology*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008297:Male; D009457:Neuroglia / Q000187:drug effects* / Q000378:metabolism*; D048789:Phytoestrogens / Q000494:pharmacology*; D015854:Up-Regulation / Q000187:drug effects; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000098742:Ferroportin
D022763:CCAAT-Enhancer-Binding Protein-alpha; D022782:CCAAT-Enhancer-Binding Protein-beta; D027682:Cation Transport Proteins; D047629:Estrogen Receptor beta; D048789:Phytoestrogens; D000098742:Ferroportin; D019833:Genistein; D007501:Iron; D002570:Ceruloplasmin; D048051:p38 Mitogen-Activated Protein Kinases