Genetic association of the neuropilin-1 gene with type 1 diabetes in children: Neuropilin-1 expression in pancreatic islets.
Minor alleles of two SNPs in intron 9 of the NRP1 gene, which encodes neuropilin-1, were found to be associated with type 1 diabetes (T1D) in children. Neuropilin-1 peptides were confined to islets in human pancreas. This suggests neuropilins-1 could influence the development of some cases of T1D in children.
Hasan
Noaman M
NM
Childrens Diabetes Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Kendrick
Mindy A
MA
Druckenbrod
Noah R
NR
Huelsmeyer
Michael K
MK
Warner
Thomas F
TF
MacDonald
Michael J
MJ
D017668:Age of Onset; D000483:Alleles; D016009:Chi-Square Distribution; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D007515:Islets of Langerhans / Q000378:metabolism*; D039942:Neuropilin-1 / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
D012333:RNA, Messenger; D039942:Neuropilin-1