title: Synergistic effects between aminoethyl-chitosans and beta-lactams against methicillin-resistant Staphylococcus aureus (MRSA).
abstract: Two kinds of aminoethyl-chitosans (AEC), AEC90 and AEC50, which had degrees of deacetylation of 90% and 50%, respectively, were prepared and their synergistic effects in combination with beta-lactams including ampicillin, penicillin, and oxacillin against two standard methicillin-resistant Staphylococcus aureus (MRSA) strains and twelve clinical isolated MRSA strains were investigated. When AECs and beta-lactams were combined, synergistic effects were observed with fractional inhibitory concentration (FIC) indices of 0.252-0.508, and the MICs of beta-lactams in the presence of AECs were dramatically reduced.
authors.affiliation: Department of Microbiology, Pukyong National University, Busan 608-737, Republic of Korea.
authors.forename: Dae-Sung
authors.initials: DS
authors.lastname: Lee
authors.forename: Young-Mog
authors.initials: YM
authors.lastname: Kim
authors.forename: Myung-Suk
authors.initials: MS
authors.lastname: Lee
authors.forename: Chang-Bum
authors.initials: CB
authors.lastname: Ahn
authors.forename: Won-Kyo
authors.initials: WK
authors.lastname: Jung
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Je
mesh_terms: D048271:Chitosan / Q000008:administration & dosage* / Q000737:chemistry; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology; D008826:Microbial Sensitivity Tests / Q000379:methods; D047090:beta-Lactams / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D047090:beta-Lactams; D048271:Chitosan