title: A1C but not serum glycated albumin is elevated because of iron deficiency in late pregnancy in diabetic women.
abstract: OBJECTIVE We have already reported that A1C is elevated because of iron deficiency in late pregnancy among nondiabetic pregnant women. This report examined whether the same phenomenon is observed in pregnant women with diabetes. RESEARCH DESIGN AND METHODS This longitudinal study was conducted in 17 pregnant women with diabetes (20-35 weeks of pregnancy). A1C, serum glycated albumin, erythrocyte indexes, and iron metabolism indexes were measured. RESULTS A1C levels were significantly increased in late pregnancy, whereas serum glycated albumin showed no significant changes. Glycated albumin/A1C ratio, mean corpuscular hemoglobin, serum transferrin saturation, and serum ferritin were significantly decreased in late pregnancy. Serum transferrin saturation showed a significant positive correlation with glycated albumin/A1C ratio. CONCLUSIONS A1C levels, but not serum glycated albumin levels, are elevated in late pregnancy because of iron deficiency in diabetic women. Serum glycated albumin may offer an adequate marker for glycemic control during pregnancy.
authors.affiliation: Department of Internal Medicine, Aizenbashi Hospital, Osaka, Japan.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Osugi
authors.forename: Sanai
authors.initials: S
authors.lastname: Noguchi
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Kenshi
authors.initials: K
authors.lastname: Wasada
authors.forename: Shiro
authors.initials: S
authors.lastname: Imai
authors.forename: Masako
authors.initials: M
authors.lastname: Waguri
authors.forename: Rieko
authors.initials: R
authors.lastname: Toyoda
authors.forename: Tomio
authors.initials: T
authors.lastname: Fujita
authors.forename: Soji
authors.initials: S
authors.lastname: Kasayama
authors.forename: Masafumi
authors.initials: M
authors.lastname: Koga
mesh_terms: D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood* / Q000378:metabolism; D048909:Diabetes Complications / Q000097:blood / Q000378:metabolism; D016640:Diabetes, Gestational / Q000097:blood* / Q000378:metabolism; D004906:Erythrocyte Count; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D017127:Glycation End Products, Advanced; D006801:Humans; D007501:Iron / Q000097:blood / Q000378:metabolism; D008137:Longitudinal Studies; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood* / Q000378:metabolism; D011262:Pregnancy Trimester, Second / Q000097:blood / Q000378:metabolism; D011263:Pregnancy Trimester, Third / Q000097:blood / Q000378:metabolism; D011254:Pregnancy in Diabetics / Q000097:blood* / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism*; D015854:Up-Regulation; D000093423:Glycated Serum Albumin
chemical_list: D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D007501:Iron; D012709:Serum Albumin; D000093423:Glycated Serum Albumin; C517652:hemoglobin A1c protein, human