title: Poly(ethylene glycol) and hydroxy functionalized alkane phosphate mixed self-assembled monolayers to control nonspecific adsorption of proteins on titanium oxide surfaces.
abstract: The spontaneous formation of alkane phosphate self-assembled monolayers (SAMs) on titanium oxide was chosen as a tool to tailor the surface physicochemical properties in terms of nonspecific adsorption of proteins. For this aim, poly(ethylene glycol)-modified (PEG) alkane phosphate was codeposited with OH-terminated alkane phosphates. X-ray photoelectron spectroscopy and ellipsometry of the resulting mixed SAMs indicate that the PEG density can be controlled by varying the mole fraction of PEG-terminated phosphates in the solutions used during the deposition process, leading to surfaces with different degrees of protein resistance.
authors.affiliation: BioMatLab, Bioengineering Department, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy. sabrina.bozzini@polimi.it
authors.forename: Sabrina
authors.initials: S
authors.lastname: Bozzini
authors.forename: Paola
authors.initials: P
authors.lastname: Petrini
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Tanzi
authors.forename: Stefan
authors.initials: S
authors.lastname: Zürcher
authors.forename: Samuele
authors.initials: S
authors.lastname: Tosatti
mesh_terms: D000327:Adsorption; D000473:Alkanes / Q000737:chemistry*; D006801:Humans; D008301:Maleimides / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry*; D056951:Photoelectron Spectroscopy; D011092:Polyethylene Glycols / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D012709:Serum Albumin / Q000737:chemistry; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000473:Alkanes; D008301:Maleimides; D010710:Phosphates; D011506:Proteins; D012709:Serum Albumin; D014867:Water; C009495:titanium dioxide; C043592:maleimide; D011092:Polyethylene Glycols; D014025:Titanium