title: Congenital rickets caused by maternal vitamin D deficiency.
abstract: The cases of four newborn infants with congenital rickets are reported. All infants were native Canadian: three were Cree and one was Inuit. One had a narrow chest and pulmonary hypoplasia, two had clinical and radiological signs of rickets with craniotabes, thickened wrists, and prominent costochondral junctions, and one had perinatal asphyxia and hydrops. All had hypocalcemia, hypophosphatemia and secondary hyperparathyroidism. Serum 25-hydroxyvitamin D levels were low in three of the infants. The four mothers had evidence of vitamin D deficiency. All infants recovered following treatment with 5000 IU oral vitamin D daily.
authors.affiliation: Departments of Pediatrics and Child Health.
authors.forename: A Micheil
authors.initials: AM
authors.lastname: Innes
authors.forename: Molly M
authors.initials: MM
authors.lastname: Seshia
authors.forename: Chitra
authors.initials: C
authors.lastname: Prasad
authors.forename: Saif
authors.initials: S
authors.lastname: Al Saif
authors.forename: Frank R
authors.initials: FR
authors.lastname: Friesen
authors.forename: Albert E
authors.initials: AE
authors.lastname: Chudley
authors.forename: Martin
authors.initials: M
authors.lastname: Reed
authors.forename: Louise A
authors.initials: LA
authors.lastname: Dilling
authors.forename: James C
authors.initials: JC
authors.lastname: Haworth
authors.forename: Cheryl R
authors.initials: CR
authors.lastname: Greenberg