Two-stage capture employing active transport enables sensitive and fast biosensors.
Nanoscale sensors enable the detection of analytes with improved signal-to-noise ratio but suffer from mass transport limitations. Molecular shuttles, assembled from, e.g., antibody-functionalized microtubules and kinesin motor proteins, can selectively capture analytes from solution and deliver the analytes to a sensor patch. This two-stage process can accelerate mass transport to nanoscale biosensors and facilitate the rapid detection of analytes. Here, the possible increase of the signal-to-noise ratio is calculated, and the optimal layout of a system which integrates active transport is determined.
Katira
Parag
P
Department of Materials Science and Engineering, University of Florida, Gainesville, Florida 32611-6400, USA.
Hess
Henry
H
D000818:Animals; D015374:Biosensing Techniques; D004058:Diffusion; D016547:Kinesins / Q000737:chemistry; D008422:Materials Testing; D008870:Microtubules / Q000737:chemistry; D015233:Models, Statistical; D008968:Molecular Conformation; D020409:Molecular Motor Proteins / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods
D020409:Molecular Motor Proteins; D016547:Kinesins