Delayed hemolytic transfusion reaction in sickle cell disease.
Delayed hemolytic transfusion reactions are potentially life-threatening complications observed in patients with sickle cell disease. We review the clinical features, pathophysiology, laboratory evaluation, and management of this complication. It is important that delayed hemolytic transfusion reactions be included in the differential diagnosis of acute pain episodes following a red blood cell transfusion in a patient with sickle cell disease.
Scheunemann
Leslie P
LP
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7305, USA.
Ataga
Kenneth I
KI
D000743:Anemia, Hemolytic / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D000755:Anemia, Sickle Cell / Q000097:blood / Q000628:therapy*; D000818:Animals; D001804:Blood Transfusion, Autologous; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D006461:Hemolysis / Q000502:physiology; D006801:Humans; D013997:Time Factors