The EmERgence of autophagosomes.
Autophagosomes are large double-membrane vesicles that enclose cytoplasmic components targeting them for degradation. Two recent reports reveal that phagophores, the autophagosome precursors, are surrounded by and connected to rough endoplasmic reticulum (ER) membranes. These results shed light on how membranes may be supplied and reorganized for autophagosomal biogenesis.
Reggiori
Fulvio
F
Department of Cell Biology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. f.reggiori@umcutrecht.nl
Tooze
Sharon A
SA
D000818:Animals; D004721:Endoplasmic Reticulum / Q000648:ultrastructure*; D007425:Intracellular Membranes / Q000378:metabolism; D050356:Lipid Metabolism; D010588:Phagosomes / Q000648:ultrastructure*