title: Long-term quality of life after radiotherapy for the treatment of anal cancer.
abstract: BACKGROUND
  Radiotherapy is the current standard of care for patients with localized squamous cell cancer of the anal canal. The goal of the current study was to evaluate long-term quality of life (QoL) in patients after this treatment.
  
  
  METHODS
  Questionnaires were mailed to 80 patients treated with definitive radiotherapy, with or without concurrent chemotherapy, for anal cancer, with a minimum 2-year interval after the completion of radiotherapy. The questionnaire included the Functional Assessment of Cancer Therapy-Colorectal (FACT-C), the Medical Outcomes Study (MOS) Sexual Problems Scale, and questions regarding demographic characteristics and comorbidities.
  
  
  RESULTS
  A total of 32 (40%) patients completed the questionnaire. There were no significant differences noted with regard to clinical and demographic characteristics between the survey responders and nonresponders. Among the 32 responders, the median dose of radiotherapy was 55 Grays (Gy), and 97% had received concurrent chemotherapy. The median interval between radiotherapy and survey participation was 5 years (range, 3-13 years). The median total FACT-C score was 108 (range, 47-128), of a maximum (best possible) score of 136. Patients who reported depression or anxiety and younger patients were found to have significantly lower total FACT-C scores. The median scores on the Physical, Social/Family, Emotional, Functional, and Colorectal subscales of the FACT-C were 20, 23, 21, 22, and 21, respectively, of maximum (best possible) scores of 28, 28, 24, 28, and 28, respectively. The median score on the MOS Sexual Problems Scale was 67 (range, 0-100), of a maximum (worst possible) score of 100.
  
  
  CONCLUSIONS
  Patients treated with radiotherapy for anal cancer reported acceptable overall QoL scores, but poor sexual function scores. Investigations are warranted into more modern radiation techniques that could potentially reduce late toxicity from radiotherapy.
authors.affiliation: Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston1515 Holcombe Boulevard, Unit 97, Houston, TX 77030, USA. PrajDas@mdanderson.org
authors.forename: Prajnan
authors.initials: P
authors.lastname: Das
authors.forename: Scott B
authors.initials: SB
authors.lastname: Cantor
authors.forename: Crystal L
authors.initials: CL
authors.lastname: Parker
authors.forename: Joan B
authors.initials: JB
authors.lastname: Zampieri
authors.forename: Andrew
authors.initials: A
authors.lastname: Baschnagel
authors.forename: Cathy
authors.initials: C
authors.lastname: Eng
authors.forename: Marc E
authors.initials: ME
authors.lastname: Delclos
authors.forename: Sunil
authors.initials: S
authors.lastname: Krishnan
authors.forename: Nora A
authors.initials: NA
authors.lastname: Janjan
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Crane
mesh_terms: D001005:Anus Neoplasms / Q000188:drug therapy / Q000523:psychology* / Q000532:radiotherapy*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000523:psychology* / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D003863:Depression / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011832:Radiation Injuries / Q000453:epidemiology; D012735:Sexual Dysfunction, Physiological / Q000523:psychology; D011795:Surveys and Questionnaires