title: Prognostic significance of WT1 mRNA and anti-WT1 antibody levels in peripheral blood in patients with myelodysplastic syndromes.
abstract: Wilms tumor gene (WT1) mRNA expression in peripheral blood cells was examined in 80 patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) transformed from MDS. Serum anti-WT1 antibody titers were also determined in 45 patients. Their long-term follow-up showed that the survival rate became worse as the WT1 mRNA level increased. In particular, a high WT1 mRNA level was a strong predictor of a short time to AML transformation even if adjusted by the International Prognostic Scoring System category. Moreover, high values of anti-WT1 antibody were an independent predictor of longer survival. These data may justify therapeutic strategies targeting WT1 molecules in MDS.
authors.affiliation: Division of Hematology, Department of Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
authors.forename: Hideto
authors.initials: H
authors.lastname: Tamura
authors.forename: Kazuo
authors.initials: K
authors.lastname: Dan
authors.forename: Norio
authors.initials: N
authors.lastname: Yokose
authors.forename: Rika
authors.initials: R
authors.lastname: Iwakiri
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Ohta
authors.forename: Hisashi
authors.initials: H
authors.lastname: Sakamaki
authors.forename: Kaoru
authors.initials: K
authors.lastname: Tohyama
authors.forename: Asaka
authors.initials: A
authors.lastname: Kondo
authors.forename: Hideya
authors.initials: H
authors.lastname: Hyodo
authors.forename: Kyoko
authors.initials: K
authors.lastname: Nakamura
authors.forename: Taishi
authors.initials: T
authors.lastname: Yamashita
authors.forename: Olga A
authors.initials: OA
authors.lastname: Elisseeva
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Oka
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Oji
authors.forename: Haruo
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Kiyoyuki
authors.initials: K
authors.lastname: Ogata
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000753:Anemia, Refractory / Q000097:blood / Q000235:genetics / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000235:genetics / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood* / Q000235:genetics* / Q000276:immunology; D011379:Prognosis; D014407:Tumor Cells, Cultured; D025721:WT1 Proteins / Q000235:genetics* / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D014408:Biomarkers, Tumor; D025721:WT1 Proteins