title: Acceptability of a non-woven device for vaginal drug delivery of microbicides or other active agents.
abstract: Vaginal microbicides could reduce incidence of HIV. However, the current method of delivering gel formulations (standard applicator) can result in acceptability concerns/issues. This study evaluated the concept of using a non-woven textile material (modified tampon) for vaginal drug delivery. The study was nested within a Phase I randomized safety trial of lime juice concentrations used intra-vaginally. Of 47 women completing the safety trial, 16 were interviewed about their experiences. Overall, women found the concept of non-woven materials for vaginal drug delivery acceptable for use in delivering yeast medications (13 of 16) and STI/HIV preventives (10 of 16).
authors.affiliation: Behavioral and Biomedical Research Department, Family Health International, P.O. Box 13950, Research Triangle Park, NC 27709, USA. cjoanis@fhi.org
authors.forename: Carol L
authors.initials: CL
authors.lastname: Joanis
authors.forename: Catherine W
authors.initials: CW
authors.lastname: Hart
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D032082:Citrus aurantiifolia; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000706:statistics & numerical data; D005260:Female; D015658:HIV Infections / Q000517:prevention & control*; D015497:HIV-1; D006801:Humans; D052576:Menstrual Hygiene Products; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D012749:Sexually Transmitted Diseases / Q000517:prevention & control*; D014622:Vaginal Creams, Foams, and Jellies / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D014622:Vaginal Creams, Foams, and Jellies