Potentiated effect of systemic administration of oxytocin on hypertonic NaCl intake in food-deprived male rats.
Subcutaneous administration of oxytocin (OT) increases water intake and sodium/urine excretion in food-deprived male rats. This study analyzes the effect of OT administration (at 0830 and 1430h) on the consumption of water and hypertonic NaCl (1.5%). In the first experiment, injections of OT increased the intake of hypertonic NaCl (but not of water) in food-deprived rats but not in ad lib-fed animals during the second 12 h (2030 to 0830) of the treatment day. The net concentration of the fluid consumed by OT/deprived animals was close to isotonic. In the second experiment, the initial effect of OT administration was an increase in urine volume and urinary sodium excretion and concentration by food-deprived animals during the first 12 h (0830 to 2030). These findings suggest that in food-deprived animals, systemic administration of OT induces NaCl intake as a consequence of previous urine loss and urinary sodium excretion.
Bernal
Antonio
A
Psychobiology, University of Granada, Campus of Cartuja, Granada, Spain. antoniobernal@ugr.es
Mahía
Javier
J
Puerto
Amadeo
A
D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004327:Drinking Behavior / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects; D005508:Food Deprivation; D008297:Male; D045283:Natriuretic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage*; D012964:Sodium / Q000097:blood / Q000652:urine; D013997:Time Factors; D014556:Urine / Q000737:chemistry; D014867:Water / Q000008:administration & dosage
D045283:Natriuretic Agents; D012462:Saline Solution, Hypertonic; D014867:Water; D010121:Oxytocin; D012964:Sodium