title: Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense.
abstract: Two cyclic diarylheptanoids, acerogenins A (1) and B (2) have been isolated from the bark of Acer nikoense as inhibitors of Na(+)-glucose cotransporter (SGLT). Acerogenins A (1) and B (2) inhibited both isoforms, SGLT1 and SGLT2. Structure-activity relationship of acerogenin derivatives on inhibitory activity of SGLT as well as conformational analysis of 1 and 2 on the basis of J-resolved HMBC spectra and X-ray analysis were discussed.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Jun
authors.initials: J
authors.lastname: Deguchi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Motegi
authors.forename: Seizo
authors.initials: S
authors.lastname: Sato
authors.forename: Chihiro
authors.initials: C
authors.lastname: Aoyama
authors.forename: Jiro
authors.initials: J
authors.lastname: Takeo
authors.forename: Motoo
authors.initials: M
authors.lastname: Shiro
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
mesh_terms: D031002:Acer; D018360:Crystallography, X-Ray; D036381:Diarylheptanoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D051269:Sodium-Glucose Transporter 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051297:Sodium-Glucose Transporter 2 / Q000378:metabolism; D000077203:Sodium-Glucose Transporter 2 Inhibitors
chemical_list: D036381:Diarylheptanoids; D010936:Plant Extracts; D051269:Sodium-Glucose Transporter 1; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors