Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography.
To assess the feasibility of small soft tissue avascular tumor micro-CT imaging with x-ray phase-contrast in-line holography, we have studied micro-CT imaging with in-line geometry of small spheroidal avascular tumor models with quiescent cell core (< 250 mum) and various distributions of the proliferating cell density (PCD) forming the outer shell. We have simulated imaging with an ultrafast laser-based x-ray source with a Mo target. We observe phase-contrast enhancement of the tumor boundaries in the reconstructed transaxial images, resulting in improved detection of small soft tissue tumors, providing that the PCD density gradient is sufficiently large.
Nesterets
Yakov
Y
CSIRO Manufacturing and Materials Technology, Clayton South, VIC, Australia, 3169.
Gureyev
Tim
T
Stevenson
Andrew
A
Pogany
Andrew
A
Wilkins
Steve
S
Kincaid
Russell
R
Ye
Hongwei
H
Vogelsang
Levon
L
Lipson
Edward
E
Coman
Ioana
I
Fourmaux
Sylvain
S
Kieffer
Jean-Claude
JC
Krol
Andrzej
A