Serial plasma concentrations of adiponectin, leptin, and resistin during therapy in children with acute lymphoblastic leukemia.
OBJECTIVE
To investigate adipocytokine secretion, at diagnosis and during chemotherapy in children with the acute lymphoblastic leukemia (ALL).


METHODS
Serial measurements (6/patient) of the anti-inflammatory cytokine adiponectin and the proinflammatory adipocytokines leptin and resistin were performed at diagnosis and in nearly the entire period of therapy (up to 21 months), in 9 patients with ALL aged 2 to 7 years (median 4.3 y). Body mass index and leukemic burden were estimated at the same time points and correlated with adipocytokine levels. Nine healthy children matched for age, sex, and body mass index were used as controls.


RESULTS
At diagnosis, mean adiponectin levels were low (P<0.001) and mean leptin and resistin levels were high, compared with controls (P<0.001). During maintenance phase, adiponectin increased significantly (P=0.024), whereas leptin and resistin decreased (P=0.018 and P=0.020, respectively), compared with baseline values. However, adiponectin, despite its progressive increase, remained at lower levels toward the end of the maintenance phase, compared with controls, (P<0.001). Delta (final-baseline) mean adiponectin was negatively correlated with leukemic burden (P=0.019), whereas delta mean leptin and resistin were positively correlated with it (P=0.011 and P=0.031, respectively).


CONCLUSIONS
Low-plasma adiponectin and high leptin and resistin level are present at the ALL diagnosis. Adipocytokines alterations are progressively restored during therapy.
Moschovi
Maria
M
Pediatric Hematology/Oncology double daggerEndocrinology, Metabolism and Diabetes Units, First Department of Pediatrics, Athens University Medical School, Aghia Sophia"Children's Hospital, Athens, Greece.
Trimis
Georgios
G
Vounatsou
Maria
M
Katsibardi
Katerina
K
Margeli
Alexandra
A
Damianos
Andreas
A
Chrousos
George
G
Papassotiriou
Ioannis
I
D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D006801:Humans; D020738:Leptin / Q000097:blood; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy; D052243:Resistin / Q000097:blood; D013997:Time Factors; D047368:Tumor Burden
D054392:Adipokines; D052242:Adiponectin; D014408:Biomarkers, Tumor; D020738:Leptin; D052243:Resistin