title: Proteomics of trypanosomatids of human medical importance.
abstract: Leishmania spp., Trypanosoma cruzi, and Trypanosoma brucei are protozoan parasites that cause a spectrum of fatal human diseases around the world. Recent completion of the genomic sequencing of these parasites has enormous relevance to the study of their biology and the pathogenesis of the diseases they cause because it opens the door to high-throughput proteomic technologies. This review encompasses studies using diverse proteomic approaches with these organisms to describe and catalogue global protein profiles, reveal changes in protein expression during development, elucidate the subcellular localisation of gene products, and evaluate host-parasite interactions.
authors.affiliation: Laboratorio de Pesquisa em Leishmaniose, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil.
authors.forename: Patricia
authors.initials: P
authors.lastname: Cuervo
authors.forename: Gilberto B
authors.initials: GB
authors.lastname: Domont
authors.forename: Jose B
authors.initials: JB
authors.lastname: De Jesus
mesh_terms: D006790:Host-Parasite Interactions; D006801:Humans; D040901:Proteomics; D015800:Protozoan Proteins / Q000032:analysis; D014345:Trypanosoma / Q000737:chemistry* / Q000235:genetics / Q000472:pathogenicity; D014352:Trypanosomiasis / Q000188:drug therapy / Q000209:etiology
chemical_list: D015800:Protozoan Proteins