title: Infection of less virulent Helicobacter pylori strains in asymptomatic healthy individuals in Thailand as a potential contributing factor to the Asian enigma.
abstract: In Thailand, gastric cancer incidence is considerably low despite the high prevalence of Helicobacter pylori infection. We investigated the prevalence of H. pylori infection and the genotypes of cagA by using 179 stool specimens obtained from asymptomatic Thai individuals. In this study, the prevalence of H. pylori infection was 43.6%, and the detection rate of cagA-positive strains was 43.5%. In addition, the proportion of the highly virulent East-Asian type of cagA was 7.2%. These results indicate that the low prevalence of cagA-positive H. pylori strain as well as the low prevalence of East-Asian genotype cagA-positive strains may contribute to the low gastric cancer incidence.
authors.affiliation: Department of Bioinformatics, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan. hiraii@sahs.med.osaka-u.ac.jp
authors.forename: Itaru
authors.initials: I
authors.lastname: Hirai
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Sasaki
authors.forename: Ai
authors.initials: A
authors.lastname: Kimoto
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Azuma
authors.forename: Varocha
authors.initials: V
authors.lastname: Mahachai
authors.forename: Piyathida
authors.initials: P
authors.lastname: Hansomburana
authors.forename: Comsun
authors.initials: C
authors.lastname: Lertkupinit
authors.forename: Somchai
authors.initials: S
authors.lastname: Luangjaru
authors.forename: Phadet
authors.initials: P
authors.lastname: Noophan
authors.forename: Rattikorn
authors.initials: R
authors.lastname: Chanatrirattanapan
authors.forename: Vanich
authors.initials: V
authors.lastname: Piyanirandr
authors.forename: Theeranan
authors.initials: T
authors.lastname: Sappajit
authors.forename: Karun
authors.initials: K
authors.lastname: Suthivarakom
authors.forename: Leelaowadee
authors.initials: L
authors.lastname: Sangsuk
authors.forename: Piyada
authors.initials: P
authors.lastname: Wangroongsarb
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D005260:Female; D005838:Genotype; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000382:microbiology*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013785:Thailand / Q000453:epidemiology; D037521:Virulence Factors / Q000235:genetics
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D037521:Virulence Factors; C080866:cagA protein, Helicobacter pylori