title: [A case of long-term survival of unresectable-advanced gastric cancer due to chemotherapy].
abstract: The case was a 50s male with chief complaints of body weight loss and nausea. A clinical finding was Stage IV gastric cancer of poorly differentiated adenocarcinoma. We diagnosed it unresectable and started 5-FU+CDDP as the first-line chemotherapy. Partial response (PR) was observed and progression free time was 7 months. After 9 courses of 5-FU+ CDDP, the tumor grew and an oral intake was getting impossible. Gastro-jejunostomy was performed and then started a weekly PTX as the second-line chemotherapy after operation. The response was progressive disease (PD) after 4 courses of weekly PTX. Then we started S-1+CPT-11 as the third-line chemotherapy. We could continue S-1+CPT-11 for 9 courses without a severe adverse effect. Overall survival was 26.2 months.
authors.affiliation: Department of Surgery, Hokkaido P.W.F.A.C Asahikawa-Kousei General Hospital.
authors.forename: Kengo
authors.initials: K
authors.lastname: Kita
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takahashi
authors.forename: Shiro
authors.initials: S
authors.lastname: Nakano
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Akabane
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Yanagida
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shomura
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hanamoto
authors.forename: Mariko
authors.initials: M
authors.lastname: Kuji
authors.forename: Futoshi
authors.initials: F
authors.lastname: Oikawa
authors.forename: Hisayuki
authors.initials: H
authors.lastname: Miyagi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy*; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000077146:Irinotecan; D002945:Cisplatin; D005472:Fluorouracil; D002166:Camptothecin