Are there any differences in acute adverse reactions among five low-osmolar non-ionic iodinated contrast media?
OBJECTIVE
The differences regarding adverse reactions in different low-osmolar non-ionic contrast media had not been investigated previously. Thus, the aims of this study were to identify differences in the incidence of adverse reactions in five different low-osmolar non-ionic contrast media.


METHODS
We prospectively recorded all adverse events associated with five different low-osmolar non-ionic contrast media used in 8,931 consecutive patients for CT. Patients were randomly assigned to five groups: iomeprol 300 mgI/ml, iopamidol 300 mgI/ml, iohexol 300 mgI/ml, iopromide 300 mgI/ml and ioversol 320 mgI/ml.


RESULTS
Adverse events were observed in 241 patients (2.7%). The incidence of acute adverse reactions was significantly higher in the following groups: (1) iomeprol (3.9%) and iopromide (3.5%) groups, (2) patients aged 59 years or less (4.5%) compared with those aged 60 years or over (1.9%), (3) the first period (3.5%) compared with the late period (2.3%), (4) those with a past history of adverse reactions to contrast media (11.2%), and (5) patients receiving contrast media for the first time (3.3%) compared with those had received it previously (2.0%).


CONCLUSIONS
The incidence of acute adverse reactions may be reduced in younger patients by using iopamidol, iohexol and ioversol.
Gomi
Tatsuya
T
Department of Radiology, Toho University Ohashi Medical Centre, Tokyo, Japan. gomi@oha.toho-u.ac.jp
Nagamoto
Masashi
M
Hasegawa
Makoto
M
Katoh
Asako
A
Sugiyama
Miki
M
Murata
Nozomu
N
Kunihiro
Toshiyuki
T
Kohda
Ehiichi
E
D000368:Aged; D003287:Contrast Media / Q000009:adverse effects*; D006801:Humans; D007472:Iohexol / Q000009:adverse effects / Q000031:analogs & derivatives; D007479:Iopamidol / Q000009:adverse effects / Q000031:analogs & derivatives; D008875:Middle Aged; D009994:Osmolar Concentration; D014057:Tomography, X-Ray Computed / Q000379:methods; D014283:Triiodobenzoic Acids / Q000009:adverse effects
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C057937:iomeprol; D007472:Iohexol; C038192:iopromide; D007479:Iopamidol; C054871:ioversol