title: Anti-inflammatory activity of roots of Ecbolium viride (Forsk) Merrill.
abstract: BACKGROUND
  Traditionally the aqueous extracts of dried roots of the plant Ecbolium viride are used for menorrhagia, rheumatism and jaundice.
  
  
  OBJECTIVE
  The aim was to evaluate the anti-inflammatory activity of Ecbolium viride extract in an in vivo model.
  
  
  METHODS
  The ethyl acetate fraction of Ecbolium viride root extract was prepared and administered orally to rats. The anti-inflammatory activity of Ecbolium viride was determined by carrageenan-induced paw edema and cotton pellet granuloma models.
  
  
  RESULTS
  Oral administration of Ecbolium viride extract reduced inflammation significantly (P<0.01) in both the carageenan paw edema and the cotton pellet granuloma models.
  
  
  CONCLUSIONS
  The results of the study supported the traditional use of Ecbolium viride in the treatment for inflammatory disease.
authors.affiliation: Department of Pharmaceutical Chemistry, Ultra College of Pharmacy, Madurai 625 020, Tamil Nadu, India.
authors.forename: K G
authors.initials: KG
authors.lastname: Lalitha
authors.forename: M G
authors.initials: MG
authors.lastname: Sethuraman
mesh_terms: D027901:Acanthaceae / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts