Anti-inflammatory activity of roots of Ecbolium viride (Forsk) Merrill.
BACKGROUND
Traditionally the aqueous extracts of dried roots of the plant Ecbolium viride are used for menorrhagia, rheumatism and jaundice.


OBJECTIVE
The aim was to evaluate the anti-inflammatory activity of Ecbolium viride extract in an in vivo model.


METHODS
The ethyl acetate fraction of Ecbolium viride root extract was prepared and administered orally to rats. The anti-inflammatory activity of Ecbolium viride was determined by carrageenan-induced paw edema and cotton pellet granuloma models.


RESULTS
Oral administration of Ecbolium viride extract reduced inflammation significantly (P<0.01) in both the carageenan paw edema and the cotton pellet granuloma models.


CONCLUSIONS
The results of the study supported the traditional use of Ecbolium viride in the treatment for inflammatory disease.
Lalitha
K G
KG
Department of Pharmaceutical Chemistry, Ultra College of Pharmacy, Madurai 625 020, Tamil Nadu, India.
Sethuraman
M G
MG
D027901:Acanthaceae / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts