Supramolecular hydrogel of a D-amino acid dipeptide for controlled drug release in vivo.
A supramolecular hydrogel based on D-amino acids, which resists hydrolysis catalyzed by proteinase K and offers long-term biostability, exhibits controlled release in vivo, as proved by the pharmacokinetics of encapsulated 125I tracers and the SPECT imaging of the hydrogel-encapsulated 131I tracers. As the first in vivo imaging investigation of the drug release properties of the supramolecular hydrogel, isotope encapsulation serves as a valid, useful assay for characterizing the controlled release properties of supramolecular hydrogels in vivo. Our results indicate that supramolecular hydrogels promise new biomaterials for controlled drug release.
Liang
Gaolin
G
Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China.
Yang
Zhimou
Z
Zhang
Rongjun
R
Li
Lihua
L
Fan
Yijun
Y
Kuang
Yi
Y
Gao
Yuan
Y
Wang
Ting
T
Lu
W William
WW
Xu
Bing
B
D000596:Amino Acids / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D004151:Dipeptides / Q000737:chemistry*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry; D007457:Iodine Radioisotopes / Q000737:chemistry; D008422:Materials Testing; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008956:Models, Chemical; D012974:Sodium Iodide / Q000737:chemistry; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
D000596:Amino Acids; D001672:Biocompatible Materials; D004151:Dipeptides; D004337:Drug Carriers; D020100:Hydrogels; D007457:Iodine Radioisotopes; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D012974:Sodium Iodide