Identification of equine cutaneous lymphangioma by application of a lymphatic endothelial cell marker.
An adult horse was presented with a mass located within the dermis and subcutis of the right forelimb. At post-mortem examination there was a marked increase in thickness of the subcutis of the right forelimb extending from the fetlock to the pectoral muscles. Microscopically, the dermis and subcutis were diffusely infiltrated by endothelial-like cells forming irregular channels and cavernous spaces. Immunohistochemical examination revealed the endothelial-like cells to express vimentin, factor VIII-related antigen and PROX-1, confirming the identity of the tumour as a lymphangioma. Ultrastructural analysis showed that the cavernous spaces were lined by a discontinuous endothelium lacking any basement membrane.
Junginger
J
J
Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany.
Rötting
A
A
Staszyk
C
C
Kramer
K
K
Hewicker-Trautwein
M
M
D000818:Animals; D020405:Dermis / Q000276:immunology* / Q000473:pathology; D005552:Forelimb / Q000276:immunology* / Q000473:pathology; D018398:Homeodomain Proteins / Q000276:immunology; D006734:Horse Diseases / Q000276:immunology* / Q000473:pathology; D006736:Horses; D007150:Immunohistochemistry; D008202:Lymphangioma / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D025521:Tumor Suppressor Proteins / Q000276:immunology; D014841:von Willebrand Factor / Q000276:immunology
D018398:Homeodomain Proteins; D025521:Tumor Suppressor Proteins; D014841:von Willebrand Factor