The effect of levamisole and levamisole+vitamin C on oxidative damage in rats naturally infected with Syphacia muris.
This study was performed to determine the effects of levamisole and levamisole+vitamin C against Syphacia muris naturally infection in rats and to detect its effect on the oxidative parameters in blood and tissues of host. For this purpose, natural infection was diagnosed using the cellophane tape method on the perianal region of rats. Infected rats (total 18) were divided into three groups. On the other hand six without helminth rats were used in this study as negative control group. Group 2 was given an orally levamisole HCl treatment with gastric gavage at a dose level of 20mg/kg body weight in distilled water, every alternate day. Group 3 was given levamisole HCl via gastric gavage at a dose level of 20mg/kg and vitamin C was given 1g/L added to the drinking water. All the treatments continued for a period of 7 days. As a result; levamisole administered to rats at dose of 20mg/kg orally 98.34% was found to be effective against adult S. muris in the rats. In addition to levamisole+vitamin C is effective to alleviate the oxidative damage in rats infected with S. muris.
Ince
Sinan
S
Department of Pharmacology and Toxicology, University of Afyon Kocatepe, Afyonkarahisar 03200, Turkey.
Kozan
Esma
E
Kucukkurt
Ismail
I
Bacak
Elif
E
D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D002374:Catalase / Q000032:analysis / Q000097:blood; D004912:Erythrocytes / Q000737:chemistry / Q000201:enzymology; D005978:Glutathione / Q000032:analysis / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D007668:Kidney / Q000737:chemistry / Q000201:enzymology; D007978:Levamisole / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000737:chemistry / Q000201:enzymology; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects*; D010123:Oxyuriasis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010124:Oxyuroidea / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000032:analysis / Q000097:blood
D000969:Antinematodal Agents; D006454:Hemoglobins; D007978:Levamisole; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D001205:Ascorbic Acid