title: Catechol-o-methyltransferase genotype and childhood trauma may interact to impact schizotypal personality traits.
abstract: We attempt to identify gene by childhood abuse interactions which predispose to the development of schizotypal traits in a familial bipolar disorder (BD) sample. Self-report measures of schizotypal personality traits (Schizotypal Personality Scale) and childhood maltreatment (Childhood Trauma Questionnaire) were administered to 222 participants from 44 families with BD. Variants of catechol-o-methyltransferase (COMT) and four other dopamine pathway-related genes: DRD4, DRD2,MAOA, and SLC6A3, were typed. BD type I (BD I) subjects scored significantly higher than their unaffected relatives on the Schizotypal Personality Scale. The val allele of the Val158 Met polymorphism of the COMT gene was associated with increased schizotypal personality trait scores in individuals exposed to higher levels of self-reported childhood trauma (p < 0.05). There was no direct effect of the val158met polymorphism on schizotypal personality traits. Further, no passive correlation between COMT genotype and childhood trauma was found. We raise the possibility that genetically-driven variation in COMT may interact with childhood trauma to contribute to the risk of developing schizotypal personality traits.
authors.affiliation: MRC/UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. savitzj@mail.nih.gov
authors.forename: Jonathan
authors.initials: J
authors.lastname: Savitz
authors.forename: Lize
authors.initials: L
authors.lastname: van der Merwe
authors.forename: Timothy K
authors.initials: TK
authors.lastname: Newman
authors.forename: Dan J
authors.initials: DJ
authors.lastname: Stein
authors.forename: Raj
authors.initials: R
authors.lastname: Ramesar
mesh_terms: D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002648:Child; D002649:Child Abuse; D004777:Environment; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D012569:Schizotypal Personality Disorder / Q000235:genetics*; D011795:Surveys and Questionnaires; D014947:Wounds and Injuries / Q000150:complications*
chemical_list: D002394:Catechol O-Methyltransferase