Effects of epsilon4 on object recognition in the non-demented elderly.
Previously we reported that apolipoprotein E (ApoE) epsilon4 negatively affects performance in the novel-image-novel-location (NINL) object recognition test in healthy non-demented elderly human study participants. In this study, the participants were invited to return for testing sessions 6 and 18 months after the baseline session. Using a longitudinal study design, effects of epsilon4 on NINL test performance were assessed in study "dropouts", participants that did not return for the second and/or third session(s), and "finishers", participants that returned for all sessions. There were effects of epsilon4 on dropout rates and NINL total scores as well as sub-scores in both dropouts and finishers. NINL total score was a predictor of epsilon4 participant dropout. Compared to non-epsilon4 dropouts, epsilon4 dropouts had lower NINL scores. In contrast, epsilon4 finishers had higher NINL scores than non-epsilon4 finishers. Thus, the NINL test could be a valuable tool in detecting pre-clinical signs of age-related cognitive impairments, particularly those associated with epsilon4 risk.
Haley
Gwendolen E
GE
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA.
Berteau-Pavy
Frederique
F
Parkv
Byung
B
Raber
Jacob
J
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics* / Q000378:metabolism; D053327:Apolipoprotein E4 / Q000235:genetics*; D016009:Chi-Square Distribution; D003071:Cognition; D003348:Cortisone / Q000378:metabolism; D005260:Female; D005838:Genotype; D015577:Geriatric Assessment; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D009922:Oregon; D010352:Patient Dropouts; D010641:Phenotype; D021641:Recognition, Psychology; D018570:Risk Assessment; D012307:Risk Factors; D012463:Saliva / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism; D013997:Time Factors
D053327:Apolipoprotein E4; D013739:Testosterone; D003348:Cortisone