title: Incidence and costs of cervical intraepithelial neoplasia in a US commercially insured population.
abstract: OBJECTIVE
  This study aimed to estimate incidence, cost per episode of care, and US population burden of cervical intraepithelial neoplasia (CIN).
  
  
  METHODS
  For women continuously enrolled in a US health plan from January 1, 1999 to December 31, 2004, medical claims were used to identify potential CIN diagnosis. Presence and grade of CIN (CIN 1, CIN 2,3, or no CIN) were verified in medical records for a randomly selected subset (n = 254). Incidence, costs, and population burden were calculated.
  
  
  RESULTS
  Annual incidence for CIN 1 and CIN 2,3 was 1.6 and 1.2 per 1,000 women, respectively. Incidence was highest among women aged 21 to 30 years (3.3 and 3.6 per 1,000) and women aged 31 to 40 years (2.9 and 2.7 per 1,000). Costs per episode of care were higher for CIN 2,3 ($1,634 vs $1,084). Estimated annual burden per 1,000 US women was $1,059 for CIN 1 and $1,803 for CIN 2,3.
  
  
  CONCLUSIONS
  We estimate that 412,000 women in the United States are diagnosed with CIN annually, with an associated cost of approximately $570 million.
authors.affiliation: 1i3 Innovus, Eden Prairie, MN 55344, USA. henry.henk@i3innovus.com
authors.forename: Henry J
authors.initials: HJ
authors.lastname: Henk
authors.forename: Ralph P
authors.initials: RP
authors.lastname: Insinga
authors.forename: Puneet K
authors.initials: PK
authors.lastname: Singhal
authors.forename: Theodore
authors.initials: T
authors.lastname: Darkow
mesh_terms: D000328:Adult; D005260:Female; D017048:Health Care Costs; D006801:Humans; D015994:Incidence; D007345:Insurance Claim Review; D007348:Insurance, Health; D008875:Middle Aged; D012720:Severity of Illness Index; D014481:United States / Q000453:epidemiology; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000191:economics* / Q000453:epidemiology*