title: Two cases of corneal perforation after oral administration of nonsteroidal anti-inflammatory drugs: oral NSAID-induced corneal damage.
abstract: OBJECTIVE
  To report 2 cases of corneal perforation associated with the use of oral nonsteroidal anti-inflammatory drugs (NSAIDs).
  
  
  METHODS
  In a 62-year-old woman and a 79-year-old woman, corneal perforation occurred after 7 days and 5 months of oral NSAIDs administration, respectively.
  
  
  RESULTS
  After NSAIDs were discontinued, the cornea epithelialized and the anterior chamber formed within 14 and 10 days, respectively.
  
  
  CONCLUSIONS
  It is well known that topical NSAIDs cause corneal perforation. Observations in the present cases suggest that the oral administration of NSAIDs may also cause corneal damage, and hence, medical professionals should consider the risk of damage to the cornea when administering these drugs orally.
authors.affiliation: Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. masuda-i@cc.okayama-u.ac.jp
authors.forename: Ikuya
authors.initials: I
authors.lastname: Masuda
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Matsuo
authors.forename: Kazuo
authors.initials: K
authors.lastname: Okamoto
authors.forename: Kyoko
authors.initials: K
authors.lastname: Matsushita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohtsuki
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D003315:Cornea / Q000187:drug effects / Q000473:pathology*; D057112:Corneal Perforation / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000188:drug therapy; D014945:Wound Healing
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal