title: Affective modulation of the startle eyeblink and postauricular reflexes in autism spectrum disorder.
abstract: Eyeblink and postauricular reflexes to standardized affective images were examined in individuals without (n = 37) and with (n = 20) autism spectrum disorders (ASDs). Affective reflex modulation in control participants replicated previous findings. The ASD group, however, showed anomalous reflex modulation patterns, despite similar self-report ratings of pictures. Specifically, the ASD group demonstrated exaggerated eyeblink responses to pleasant images and exaggerated postauricular responses to unpleasant images. Although ASD is often conceptualized in terms of specific deficits in affective responding in the social domain, the present results suggest a domain-general pattern of deficits in affective processing and that such deficits may arise at an early phase in the stream of information processing.
authors.affiliation: Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7160, USA. dichter@biac.duke.edu
authors.forename: Gabriel S
authors.initials: GS
authors.lastname: Dichter
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Benning
authors.forename: Tia N
authors.initials: TN
authors.lastname: Holtzclaw
authors.forename: James W
authors.initials: JW
authors.lastname: Bodfish
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000339:Affect / Q000502:physiology*; D001143:Arousal / Q000502:physiology; D001767:Blinking / Q000502:physiology*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000503:physiopathology*; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D010775:Photic Stimulation; D012018:Reflex / Q000502:physiology*