title: Enantioselective desymmetrization of diphenylphosphinamides via (-)-sparteine-mediated ortho-lithiation. Synthesis of P-chiral ligands.
abstract: Asymmetric ortho-lithiation of N-dialkyl-P,P-diphenylphosphinamides using [n-BuLi.(-)-sparteine] is described as an efficient method for the synthesis of P-chiral ortho-functionalized derivatives in high yields and ee's from 45 to >99%. The method allows access to new enantiomerically pure P-chiral phosphine and diimine ligands.
authors.affiliation: Area de Química Orgánica, Universidad de Almería, Carretera de Sacramento s/n, 04120 Almería, Spain.
authors.forename: Cristinel
authors.initials: C
authors.lastname: Popovici
authors.forename: Pascual
authors.initials: P
authors.lastname: Oña-Burgos
authors.forename: Ignacio
authors.initials: I
authors.lastname: Fernández
authors.forename: Laura
authors.initials: L
authors.lastname: Roces
authors.forename: Santiago
authors.initials: S
authors.lastname: García-Granda
authors.forename: María José
authors.initials: MJ
authors.lastname: Iglesias
authors.forename: Fernando
authors.initials: F
authors.lastname: López Ortiz