Four new ent-kauranoids from Isodon rubescens var. lushanensis and data reassignment of dayecrystal B.
Four new 7, 20-epoxy-ent-kauranoids, rubluanins A-D (1-4) and eleven known ones, were isolated from Isodon rubescens var. lushanensis, and their structures were elucidated by spectroscopic analysis. Compounds 2-14 were evaluated for their cytotoxicity in several human tumor cell lines (U937, Jurkat, HL-60, K562, SGC790, and HepG2). Among the compounds, lasiokaurin (13) showed significant cytotoxic activity of 0.62 microM (IC(50)) in U937 cells.
Zhang
Hai-Bo
HB
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
Pu
Jian-Xin
JX
Wang
Yuan-Yuan
YY
He
Fei
F
Zhao
Yong
Y
Li
Xiao-Nian
XN
Luo
Xiao
X
Xiao
Wei-Lie
WL
Li
Yan
Y
Sun
Han-Dong
HD
D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis* / Q000302:isolation & purification / Q000493:pharmacokinetics*; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D045786:Diterpenes, Kaurane / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045786:Diterpenes, Kaurane; C011893:lasiokaurin