[Evaluation of morphine metabolism in presence of amantadine and dextromethorphan in human serum by high performance liquid chromatography coupled with mass spectrometry (LC/MS) method].
In the present study we assessed by LC/MS method the influence of amantadine and dextromethorphan on morphine metabolism in humans in order to explain clinically observed phenomenon of amplification of analgesic action of morphine by these drugs. Neither dextromethorphan nor amantadine influenced the rate of morphine degradation and concentration of morphine metabolites. Thus, our results suggest pharmacodynamical, not pharmacokinetic mechanism of interaction.
Suski
Maciej
M
Katedra Farmakologii, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków, Poland. macieksuski@gmail.com
Bujak-Gizycka
Beata
B
Madej
Józef
J
Olszanecki
Rafał
R
Korbut
Ryszard
R
D000547:Amantadine / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D003915:Dextromethorphan / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D013058:Mass Spectrometry; D009020:Morphine / Q000097:blood* / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy; D017288:Pain Threshold / Q000187:drug effects
D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D003915:Dextromethorphan; D009020:Morphine; D000547:Amantadine