Significant association of DNA repair gene Ku80 genotypes with breast cancer susceptibility in Taiwan.
OBJECTIVE
To evaluate the association between the genotypes of the heterodimeric DNA-binding component, Ku80 gene and the breast cancer risk in Taiwan.


METHODS
In this hospital-based case-control study, the association of Ku80 G-1401T rs828907, Ku80 C-319T rs11685387 and Ku80 intron19 rs9288518 polymorphisms with breast cancer risk in a Taiwanese population was investigated. In total, 1272 patients with breast cancer and the same number of age- and gender-matched healthy controls were genotyped.


RESULTS
A significantly different distribution was found in the frequency of the Ku80 G-1401T genotype, but not the Ku80 C-319T or intron 19 genotypes, between the breast cancer and control groups. The T allele Ku80 G-1401T conferred a significant (p=0.0069) increased risk of breast cancer. Gene interactions with smoking, but not with breastfeeding, were significant for the Ku80 G-1401T polymorphism. The Ku80 G-1401T GT and TT genotypes in association with smoking conferred an increased risk of 3.162 (95% confidence interval=2.275-4.393) for breast cancer.


CONCLUSIONS
The T allele of Ku80 G-1401T may be associated with the development of breast cancer and may be a novel useful marker for breast cancer detection and prediction.
Wang
Hwei-Chung
HC
Department of Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Liu
Chiu-Shong
CS
Chiu
Chang-Fang
CF
Chiang
Su-Yin
SY
Wang
Chung-Hsing
CH
Wang
Rou-Fen
RF
Lin
Cheng-Chieh
CC
Tsai
Ru-Yin
RY
Bau
Da-Tian
DT
D034961:Antigens, Nuclear / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D004260:DNA Repair / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D000072200:Ku Autoantigen; D008875:Middle Aged; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D013624:Taiwan
D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen