Brain serotonin-2 receptors in acute mania.
BACKGROUND
Although 5-hydroxytryptamine (5-HT) has been implicated in mania, the precise alterations in the 5-HT system remain elusive.


OBJECTIVE
To assess brain 5-HT2 receptors in drug-free individuals experiencing a manic episode in comparison with healthy volunteers using positron emission tomography (PET).


METHODS
Participants (n = 10) with DSM-IV bipolar I disorder-manic episode and healthy controls (n = 10) underwent [18F]-setoperone scans. The differences in 5-HT2 receptor binding potential between the two groups were determined using statistical parametric mapping (SPM) analysis.


RESULTS
Age was a significant correlate with 5-HT2 receptor binding potential with a similar magnitude of correlation in both groups. The SPM analysis with age as a covariate showed that the individuals with current mania had significantly lower 5-HT2 receptor binding potential in frontal, temporal, parietal and occipital cortical regions, with changes more prominent in the right cortical regions compared with controls.


CONCLUSIONS
This study suggests that brain 5-HT2 receptors are decreased in people with acute mania.
Yatham
Lakshmi N
LN
Mood Disorders Program, University of British Columbia, Vancouver, Canada. yatham@exchange.ubc.ca
Liddle
Peter F
PF
Erez
Jonathan
J
Kauer-Sant'Anna
Marcia
M
Lam
Raymond W
RW
Imperial
Miguel
M
Sossi
Vesna
V
Ruth
Thomas J
TJ
D000328:Adult; D000367:Age Factors; D001714:Bipolar Disorder / Q000000981:diagnostic imaging / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D001931:Brain Mapping; D016022:Case-Control Studies; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D044348:Receptors, Serotonin, 5-HT2 / Q000378:metabolism*; D055815:Young Adult
D044348:Receptors, Serotonin, 5-HT2