Epidemiological study of rickettsial infections in patients with hypertransaminemia in Madrid (Spain).
A retrospective analysis was performed to detect anti-rickettsial antibodies in the serum of patients with hypertransaminemia of unknown etiology, and in that of healthy members of the general population of Madrid (Spain). Among 143 patients 16 (11.2%) were positive for anti-R. conorii IgG antibodies and 7% for R. typhi. PCR analysis was performed in patients with IgM antibodies. Among 143 healthy subjects from the general population, seven (4.9%) were positive for anti-R. conorii IgG antibodies, and 2.8% for R. typhi. These results show that anti-rickettsial antibodies are more commonly detected in patients with hypertransaminemia than in healthy people.
Lledó
Lourdes
L
Department of Microbiology and Parasitology, Faculty of Medicine, University of Alcalá, Ctra. Madrid-Barcelona Km 33.6, Alcalá de Henares 28871, Spain. lourdes.lledo@uah.es
González
Rosario
R
Gegúndez
María Isabel
MI
Beltrán
María
M
Saz
José Vicente
JV
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood*; D000907:Antibodies, Bacterial / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood*; D016022:Case-Control Studies; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012282:Rickettsia Infections / Q000201:enzymology / Q000453:epidemiology* / Q000276:immunology; D020114:Rickettsia conorii / Q000276:immunology; D012286:Rickettsia typhi / Q000276:immunology; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D055815:Young Adult
D000907:Antibodies, Bacterial; D007075:Immunoglobulin M; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase