title: Association between outcome and organ system dysfunction in dogs with sepsis: 114 cases (2003-2007).
abstract: OBJECTIVE
  To determine whether multiple organ dysfunction syndrome (MODS) could be identified in dogs with sepsis secondary to gastrointestinal tract leakage, and whether the number of affected organ systems was significantly associated with mortality rate.
  
  
  METHODS
  Multicenter retrospective case series.
  
  
  METHODS
  114 dogs.
  
  
  METHODS
  Medical records for dogs treated surgically because of sepsis secondary to gastrointestinal tract leakage between 2003 and 2007 were reviewed. Sepsis was diagnosed on the basis of results of bacterial culture of peritoneal fluid, gross evidence of gastrointestinal tract leakage at surgery, or both. Renal dysfunction was defined as a > or = 0.5 mg/dL increase in serum creatinine concentration after surgery. Cardiovascular dysfunction was defined as hypotension requiring vasopressor treatment. Respiratory dysfunction was defined as a need for supplemental oxygen administration or mechanical ventilation. Hepatic dysfunction was defined as a serum bilirubin concentration > 0.5 mg/dL. Dysfunction of coagulation was defined as prolonged prothrombin time, prolonged partial thromboplastin time, or platelet count < or = 100,000/microL.
  
  
  RESULTS
  89 (78%) dogs had dysfunction of 1 or more organ systems, and 57 (50%) dogs had MODS. Mortality rate increased as the number of dysfunctional organ systems increased. Mortality rate was 70% (40/57) for dogs with MODS and 25% (14/57) for dogs without.
  
  
  CONCLUSIONS
  Results indicated that MODS, defined as dysfunction of at least 2 organ systems, can be identified in dogs with sepsis and that organ system dysfunction increased the odds of death.
authors.affiliation: Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.
authors.forename: Eileen M
authors.initials: EM
authors.lastname: Kenney
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Rozanski
authors.forename: John E
authors.initials: JE
authors.lastname: Rush
authors.forename: Armelle M
authors.initials: AM
authors.lastname: deLaforcade-Buress
authors.forename: John R
authors.initials: JR
authors.lastname: Berg
authors.forename: Deborah C
authors.initials: DC
authors.lastname: Silverstein
authors.forename: Catalina D
authors.initials: CD
authors.lastname: Montealegre
authors.forename: L Ari
authors.initials: LA
authors.lastname: Jutkowitz
authors.forename: Sophie
authors.initials: S
authors.lastname: Adamantos
authors.forename: Dianna H
authors.initials: DH
authors.lastname: Ovbey
authors.forename: Soren R
authors.initials: SR
authors.lastname: Boysen
authors.forename: Scott P
authors.initials: SP
authors.lastname: Shaw
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000453:epidemiology* / Q000401:mortality* / Q000473:pathology; D004285:Dogs; D005260:Female; D041981:Gastrointestinal Tract / Q000293:injuries; D008297:Male; D009102:Multiple Organ Failure / Q000453:epidemiology / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D011379:Prognosis; D012189:Retrospective Studies; D018805:Sepsis / Q000453:epidemiology / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D012720:Severity of Illness Index