title: Ocular changes in primary hypothyroidism.
abstract: BACKGROUND
  To determine the ocular changes related to hypothyrodism in newly diagnosed patients without orbitopathy.
  
  
  RESULTS
  Thirty-three patients diagnosed to have primary overt hypothyroidism were enrolled in the study. All subjects were assigned to underwent central corneal thickness (CCT), anterior chamber volume, depth and angle measurements with the Scheimpflug camera (Pentacam, Oculus) and cup to disc ratio (C/D), mean retinal thickness and mean retinal nerve fiber layer (RNFL) thickness measurements with optical coherence tomography (OCT) in addition to ophthalmological examination preceeding the replacement therapy and at the 1(st), 3(rd )and 6(th )months of treatment. The mean age of the patients included in the study were 40.58 +/- 1.32 years. The thyroid hormone levels return to normal levels in all patients during the follow-up period, however the mean intraocular pressure (IOP) revealed no significant change. The mean CCT was 538.05 +/- 3.85 mu initially and demonstrated no statistically significant change as the anterior chamber volume, depth and angle measurements did. The mean C/D ratio was 0.29 +/- 0.03 and the mean retinal thickness was 255.83 +/- 19.49 mu initially and the treatment did not give rise to any significant change. The mean RNFL thickness was also stable during the control visits, so no statistically significant change was encountered.
  
  
  CONCLUSIONS
  Neither hypothyroidism, nor its replacement therapy gave rise to any change of IOP, CCT, anterior chamber parameters, RNFL, retinal thickness and C/D ratio.
authors.affiliation: Department of Ophthalmology, Meram Faculty of Medicine, Selcuk University, Konya, Turkey.
authors.forename: Banu T
authors.initials: BT
authors.lastname: Ozturk
authors.forename: Hurkan
authors.initials: H
authors.lastname: Kerimoglu
authors.forename: Oguz
authors.initials: O
authors.lastname: Dikbas
authors.forename: Hamiyet
authors.initials: H
authors.lastname: Pekel
authors.forename: Mustafa S
authors.initials: MS
authors.lastname: Gonen