Recent approaches for enhancing sensitivity in enantioseparations by CE.
This article reviews the latest methodological and instrumental improvements for enhancing sensitivity in chiral analysis by CE. The review covers literature from March 2007 until May 2009, that is, the works published after the appearance of the latest review article on the same topic by Sánchez-Hernández et al. [Electrophoresis 2008, 29, 237-251]. Off-line and on-line sample treatment techniques, on-line sample preconcentration strategies based on electrophoretic and chromatographic principles, and alternative detection systems to the widely employed UV/Vis detection in CE are the most relevant approaches discussed for improving sensitivity. Microchip technologies are also included since they can open up great possibilities to achieve sensitive and fast enantiomeric separations.
Sánchez-Hernández
Laura
L
Departamento de Química Analítica, Universidad de Alcalá, Madrid, Spain.
García-Ruiz
Carmen
C
Luisa Marina
María
M
Luis Crego
Antonio
A
D005591:Chemical Fractionation / Q000379:methods*; D019075:Electrophoresis, Capillary / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis; D011506:Proteins / Q000032:analysis; D012680:Sensitivity and Specificity; D013237:Stereoisomerism
D004364:Pharmaceutical Preparations; D011506:Proteins