Changes in regional activity are accompanied with changes in inter-regional connectivity during 4 weeks motor learning.
Structural equation modeling (SEM) and fMRI were used to test whether changes in the regional activity are accompanied by changes in the inter-regional connectivity as motor practice progresses. Ten healthy subjects were trained to perform finger movement task daily for 4 weeks. Three sessions of fMRI images were acquired within 4 weeks. The changes in inter-regional connectivity were evaluated by measuring the effective connectivity between the primary motor area (M1), supplementary motor area (SMA), dorsal premotor cortex (PMd), basal ganglia (BG), cerebellum (CB), and posterior ventrolateral prefrontal cortex (pVLPFC). The regional activities in M1 and SMA increased from pre-training to week 2 and decreased from week 2 to week 4. The inter-regional connectivity generally increased in strength (with SEM path coefficients becoming more positive or negative) as practice progressed. The increases in the strength of the inter-regional connectivity may reflect long-term reorganization of the skilled motor network. We suggest that the performance gain was achieved by dynamically tuning the inter-regional connectivity in the motor network.
Ma
Liangsuo
L
Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, TX 77030, USA. liangsuo.ma@uth.tmc.edu
Wang
Binquan
B
Narayana
Shalini
S
Hazeltine
Eliot
E
Chen
Xiying
X
Robin
Donald A
DA
Fox
Peter T
PT
Xiong
Jinhu
J
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007858:Learning / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009048:Motor Skills / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D011214:Practice, Psychological; D012815:Signal Processing, Computer-Assisted; D013647:Task Performance and Analysis; D013997:Time Factors; D055815:Young Adult