Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS).
OBJECTIVE
To describe mortality and disease-specific morbidities in patients with mild primary hyperparathyroidism (PHPT).


METHODS
Retrospective population-based observational study.


METHODS
Tayside, Scotland, from 1997 to 2006.


METHODS
Patients with mild PHPT were selected from a predefined PHPT cohort between 1997 and 2006.


METHODS
Standardised mortality ratios (SMRs) were examined for all-cause mortality, as well as cardiovascular and cancer mortality. Standardised morbidity ratios and standardised incidence ratios were also calculated for eleven observed co-morbidities.


RESULTS
In total, there were 1683 (69.1% female) patients identified with mild PHPT in Tayside. Patients were found to have an increased risk of all-cause mortality and cardiovascular mortality (SMR-all cause 2.62, 95% CI 2.39-2.86; SMR-cardiovascular 2.68, 95% CI 2.34-3.05). Patients with mild PHPT had a significantly increased risk of developing cardiovascular and cerebrovascular disease, renal dysfunction and fractures compared to the age- and sex-adjusted general population.


CONCLUSIONS
Mortality and morbidity were increased for patients with mild untreated PHPT, which is similar to more severe PHPT.
Yu
Ning
N
Dundee Epidemiology and Biostatistics Unit, Division of Clinical & Population Sciences & Education, University of Dundee, Scotland, UK.
Donnan
Peter T
PT
Flynn
Robert W V
RW
Murphy
Michael J
MJ
Smith
David
D
Rudman
Andrew
A
Leese
Graham P
GP
D000328:Adult; D000368:Aged; D002118:Calcium / Q000097:blood; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002561:Cerebrovascular Disorders / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000453:epidemiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D012189:Retrospective Studies; D012606:Scotland / Q000453:epidemiology
D002118:Calcium