title: Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles.
abstract: The first continuous flow synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids directly from 2-aminopyridines and bromopyruvic acid has been developed, representing a significant advance over the corresponding in-flask method. The process was applied to the multistep synthesis of imidazo[1,2-a]pyridine-2-carboxamides, including a Mur ligase inhibitor, using a two microreactor, multistep continuous flow process without isolation of intermediates.
authors.affiliation: Program in Apoptosis and Cell Death Research and Conrad Prebys Center for Chemical Genomics, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Ananda
authors.initials: A
authors.lastname: Herath
authors.forename: Russell
authors.initials: R
authors.lastname: Dahl
authors.forename: Nicholas D P
authors.initials: ND
authors.lastname: Cosford
mesh_terms: D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D002264:Carboxylic Acids; D007093:Imidazoles; D011725:Pyridines