title: Biopsy examination of squamous cell carcinoma of the tongue: source of significant prognostic information?
abstract: Histological analysis of tumour resection for squamous cell carcinoma (SCC) of the tongue yields prognostic information. We analysed histological slides of biopsy and tumour resection specimens using an adapted malignancy grading score and analysed variables of neck dissections. There was moderate correlation between biopsy and tumour resection using malignancy grading scores (correlation coefficient 0.45); good agreement of tumour grade (79%), tumour depth (76%), and type of invasive front (80%), but correlation was only fair to moderate (κ=0.38, κ=0.51, and κ=0.41, respectively). Correlation of the biopsy grading score and invaded nodes in the neck, extra capsular spread, and soft tissue disease was not significant.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK.
authors.forename: J W
authors.initials: JW
authors.lastname: Moor
authors.forename: S
authors.initials: S
authors.lastname: Wills
authors.forename: F
authors.initials: F
authors.lastname: Holzle
authors.forename: T K
authors.initials: TK
authors.lastname: Ong
authors.forename: D A
authors.initials: DA
authors.lastname: Mitchell
authors.forename: K A
authors.initials: KA
authors.lastname: MacLennan
authors.forename: A N
authors.initials: AN
authors.lastname: Kanatas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000145:classification*; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D005927:Glossectomy; D006801:Humans; D007633:Keratins / Q000032:analysis; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008938:Mitosis; D037981:Neck Dissection; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D010950:Plasma Cells / Q000473:pathology; D011379:Prognosis; D014062:Tongue Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D007633:Keratins