Evaluation of Myanmar medicinal plant extracts for antitrypanosomal and cytotoxic activities.
Current chemotherapeutic options for African trypanosomiasis in humans and livestock are very limited. In the present study, a total of 71 medicinal plant specimens from 60 plant species collected in Myanmar were screened for antitrypanosomal activity against trypomastigotes of Trypanosoma evansi and cytotoxicity against MRC-5 cells in vitro. The methanol extract of dried rootbark of Vitis repens showed the highest antitrypanosomal activity with IC(50) value of 8.6 +/- 1.5 microg/ml and the highest selectivity index of 24.4. The extracts of Brucea javanica, Vitex arborea, Eucalyptus globulus and Jatropha podagrica had also remarkable activity with IC(50) values and selectivity indices in the range of 27.2-52.6 microg/ml and 11.4-15.1 respectively.
Bawm
Saw
S
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University.
Tiwananthagorn
Saruda
S
Lin
Kyaw San
KS
Hirota
Junichi
J
Irie
Takao
T
Htun
Lat Lat
LL
Maw
Ni Ni
NN
Myaing
Tin Tin
TT
Phay
Nyunt
N
Miyazaki
Satoshi
S
Sakurai
Tatsuya
T
Oku
Yuzaburo
Y
Matsuura
Hideyuki
H
Katakura
Ken
K
D000818:Animals; D001208:Asia / Q000453:epidemiology; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D002052:Myanmar; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D010946:Plants, Medicinal / Q000737:chemistry / Q000145:classification; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D014345:Trypanosoma / Q000187:drug effects; D014352:Trypanosomiasis / Q000188:drug therapy* / Q000453:epidemiology / Q000662:veterinary
D010936:Plant Extracts; D014344:Trypanocidal Agents