title: Retinal nerve fiber layer thickness in normals measured by spectral domain OCT.
abstract: OBJECTIVE
  To determine normal values for peripapillary retinal nerve fiber layer thickness (RNFL) measured by spectral domain Optical Coherence Tomography (SOCT) in healthy white adults and to examine the relationship of RNFL with age, gender, and clinical variables.
  
  
  METHODS
  The peripapillary RNFL of 170 healthy patients (96 males and 74 females, age 20 to 78 y) was imaged with a high-resolution SOCT (Spectralis HRA+OCT, Heidelberg Engineering) in an observational cross-sectional study. RNFL thickness was measured around the optic nerve head using 16 automatically averaged, consecutive circular B-scans with 3.4-mm diameter. The automatically segmented RNFL thickness was divided into 32 segments (11.25 degrees each). One randomly selected eye per subject entered the study.
  
  
  RESULTS
  Mean RNFL thickness in the study population was 97.2 ± 9.7 μm. Mean RNFL thickness was significantly negatively correlated with age (r = -0.214, P = 0.005), mean RNFL decrease per decade was 1.90 μm. As age dependency was different in different segments, age-correction of RNFL values was made for all segments separately. Age-adjusted RNFL thickness showed a significant correlation with axial length (r = -0.391, P = 0.001) and with refractive error (r = 0.396, P<0.001), but not with disc size (r = 0.124).
  
  
  CONCLUSIONS
  Normal RNFL results with SOCT are comparable to those reported with time-domain OCT. In accordance with the literature on other devices, RNFL thickness measured with SOCT was significantly correlated with age and axial length. For creating a normative database of SOCT RNFL values have to be age adjusted.
authors.affiliation: Department of Ophthalmology, University of Erlangen-Nürnberg, Germany. delia.bendschneider@uk-erlangen.de
authors.forename: Delia
authors.initials: D
authors.lastname: Bendschneider
authors.forename: Ralf P
authors.initials: RP
authors.lastname: Tornow
authors.forename: Folkert K
authors.initials: FK
authors.lastname: Horn
authors.forename: Robert
authors.initials: R
authors.lastname: Laemmer
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Roessler
authors.forename: Anselm G
authors.initials: AG
authors.lastname: Juenemann
authors.forename: Friedrich E
authors.initials: FE
authors.lastname: Kruse
authors.forename: Christian Y
authors.initials: CY
authors.lastname: Mardin
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers; D009898:Optic Disk / Q000033:anatomy & histology*; D012016:Reference Values; D012165:Retinal Ganglion Cells / Q000166:cytology*; D012737:Sex Factors; D041623:Tomography, Optical Coherence; D055815:Young Adult