title: Switching the chemoselectivity in the amination of 4-chloroquinazolines with aminopyrazoles.
abstract: The chemoselectivity in the amination of 4-chloroquinazolines with 3-amino-1H-pyrazoles was studied. Under the conditions of Pd(2)(dba)(3)/Xantphos/Na(2)CO(3), 4-chloroquinazolines underwent selective amination with the cyclic secondary amino group of 3-amino-1H-pyrazoles, whereas 4-chloroquinazolines were exclusively aminated with the primary amino group of 3-amino-1H-pyrazoles via S(N)Ar substitution in the presence of HCl.
authors.affiliation: College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, China. zhenlushen@zjut.edu.cn
authors.forename: Zhenlu
authors.initials: Z
authors.lastname: Shen
authors.forename: Yiming
authors.initials: Y
authors.lastname: Hong
authors.forename: Xiaofei
authors.initials: X
authors.lastname: He
authors.forename: Weimin
authors.initials: W
authors.lastname: Mo
authors.forename: Baoxiang
authors.initials: B
authors.lastname: Hu
authors.forename: Nan
authors.initials: N
authors.lastname: Sun
authors.forename: Xinquan
authors.initials: X
authors.lastname: Hu
mesh_terms: D000586:Amination; D002384:Catalysis; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry*; D011799:Quinazolines / Q000737:chemistry*
chemical_list: D006843:Hydrocarbons, Chlorinated; D011720:Pyrazoles; D011799:Quinazolines