[Expression of thymic stromal lymphopoietin in nasal mucosa of a mouse model with allergic rhinitis].
OBJECTIVE
To investigate the expression of thymic stromal lymphopoietin (TSLP) in the nasal mucosa of mouse with allergic rhinitis.


METHODS
Twenty wide type BALB/c mouse were divided into 2 groups randomly. Two groups were included, allergic rhinitis group (group A) and control group (group B). The mouse model of allergic rhinitis was established by ovalbumin (OVA) sensitization and challenge. The expressions of TSLP in the nasal mucosa was determined by realtime quantitative PCR and immunohistochemical method.


RESULTS
The expression of TSLP in the nasal mucosa of group A was significantly higher than that in group B (P<0.01).


CONCLUSIONS
TSLP plays a role in the mouse model of allergic rhinitis.
Xu
Meili
M
Department of ICU, Zhongshan Hospital, Xiamen University, Xiamen, 361004, China.
Guo
Yongqing
Y
D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D009297:Nasal Mucosa / Q000378:metabolism*; D010047:Ovalbumin / Q000096:biosynthesis; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*; D000094632:Thymic Stromal Lymphopoietin
D016207:Cytokines; D010047:Ovalbumin; D000094632:Thymic Stromal Lymphopoietin; C000721967:TSLP protein, mouse