title: The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!
abstract: Dynamic interactions of cells with their environment regulate multiple aspects of tissue morphogenesis and function. Integrins are the major class of cell surface receptors that recognize and bind extracellular matrix proteins, resulting in the engagement and organization of the cytoskeleton as well as activation of signalling pathways to regulate cell behaviour and morphogenetic processes. The ternary complex of integrin-linked kinase (ILK), PINCH, and parvin (IPP complex), which was identified more than a decade ago, interacts with the cytoplasmic tail of beta integrins and couples them to the actin cytoskeleton. In addition, ILK has been shown to act as a serine/threonine kinase and to directly activate several signalling pathways downstream of integrins. However, the kinase activity of ILK and the precise functions of the IPP complex have remained elusive and controversial. This review focuses on the recent advances made towards understanding the specialized roles this complex and its individual components have acquired during evolution.
authors.affiliation: Department for Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany.
authors.forename: Sara A
authors.initials: SA
authors.lastname: Wickström
authors.forename: Anika
authors.initials: A
authors.lastname: Lange
authors.forename: Eloi
authors.initials: E
authors.lastname: Montanez
authors.forename: Reinhard
authors.initials: R
authors.lastname: Fässler
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D009024:Morphogenesis; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D000099200:Scaffold Protein ILK
chemical_list: D004268:DNA-Binding Proteins; D008840:Microfilament Proteins; D017346:Protein Serine-Threonine Kinases; D000099200:Scaffold Protein ILK