Gender differences in platelet aggregation in healthy individuals.
This study evaluated gender variability in platelet aggregation in response to common agonists. Platelet aggregation was measured in 36 healthy men and women free of any antiplatelet medication, aged 22-36 years, of Caucasian (White not of Hispanic origin), Hispanic, and African-American not of Hispanic origin. In this ex-vivo study, we investigated platelet aggregation in response to adenosine-5'-diphosphate (ADP), epinephrine (EPI), arachidonic acid (AA) and collagen (COL), using a platelet ionized calcium aggregometer (Chrono-Log Co.). Platelet aggregation response to all tested agonists was higher in females than in males regardless of ethnicity. The most significant differences were observed with collagen (P < 0.01). Among the ethnic groups, Caucasian women were most prone to platelet aggregation. Gender is a determinant of agonist effects on platelet aggregability in healthy subjects.
Otahbachi
Mohammad
M
Department of Internal Medicine, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA.
Simoni
Jan
J
Simoni
Grace
G
Moeller
John F
JF
Cevik
Cihan
C
Meyerrose
Gary E
GE
Roongsritong
Chanwit
C
D000244:Adenosine Diphosphate; D000328:Adult; D001741:Black or African American; D016718:Arachidonic Acid; D003094:Collagen; D004837:Epinephrine; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D010974:Platelet Aggregation; D010979:Platelet Function Tests; D012016:Reference Values; D012737:Sex Factors; D013781:Texas; D044465:White People; D055815:Young Adult
D016718:Arachidonic Acid; D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine