title: Intracranial plasmacytoma with apoplectic presentation and spontaneous intracerebral hemorrhage: Case report and review of the literature.
abstract: Involvement of the nervous system is not uncommon in patients with multiple myeloma, with polyneuropathy and myelopathy predominating. Intracranial involvement producing neurological symptoms, however, is distinctly uncommon. Massive intraparenchymal hemorrhage from a previously unrecognized intracranial plasmacytoma is exceedingly rare. The authors report the case of a 57-year-old male who presented with sudden onset of severe headache, rapid onset of right-sided weakness and deterioration in level of consciousness while at work. Two years earlier the patient had completed treatment for multiple myeloma and was considered to be in remission, with a recent bone marrow biopsy that was negative, and complete normalization of serum protein electrophoresis. Imaging studies revealed a massive intracerebral hemorrhage with the possibility of an underlying lesion, and the patient was taken for emergent hematoma evacuation and tumor resection. The patient made an excellent recovery and was treated with intracranial radiation. Even in patients with multiple myeloma without evidence of systemic disease following successful treatment, the possibility of unrecognized lesions lingers. The onset of new symptoms referable to potential intracranial pathology in this setting should prompt consideration of intracranial plasmacytoma in the differential diagnosis.
authors.affiliation: Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville, 22908, United States.
authors.forename: R Webster
authors.initials: RW
authors.lastname: Crowley
authors.forename: Charles A
authors.initials: CA
authors.lastname: Sansur
authors.forename: Jason P
authors.initials: JP
authors.lastname: Sheehan
authors.forename: James W
authors.initials: JW
authors.lastname: Mandell
authors.forename: Neal F
authors.initials: NF
authors.lastname: Kassell
authors.forename: Aaron S
authors.initials: AS
authors.lastname: Dumont
mesh_terms: D000911:Antibodies, Monoclonal / Q000097:blood; D001416:Back Pain / Q000209:etiology; D001932:Brain Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000601:surgery; D003937:Diagnosis, Differential; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007147:Immunoglobulin Light Chains / Q000097:blood; D008297:Male; D008875:Middle Aged; D010954:Plasmacytoma / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D007070:Immunoglobulin A; D007147:Immunoglobulin Light Chains