[Treatment of complicated cavernous venous malformation with retained copper wires combined with pingyangmycin injection].
OBJECTIVE
To evaluate the therapeutic effect of retained copper wires combined with pingyangmycin (PYM) injection for complicated cavernous venous malformation.


METHODS
The location of venous malformation was detected by physical examination and MRI. The copper wires in 0.2 mm width were used to puncture the lesion repeatedly and retained in the lesion to form a net. After that, 8 mg PYM was injected into the residue malformed veins. 8-10 days later, the copper wires were taken out and necrotic tissue was squeezed out. The wounds of punctual holes healed through dressing. The patients received postoperative MRI to evaluate the therapeutic effect.


RESULTS
From Jan. 2002 to Dec. 2008, 45 cases were treated. The patients were followed up for 1-3 years. 51.1% (23/45) of the lesions shrinked markedly or even disappeared. 42.2% (19/45) of the lesions reduced. 6.67% (3/45) of the lesions didn't change. There was no complication like invasive infection.


CONCLUSIONS
It is very effective to treat complicated cavernous venous malformation with retained copper wires combined with pingyangmycin injection.
Yuan
Si-Ming
SM
Department of Plastic and Burn Surgery, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, China.
Jiang
Hui-Qing
HQ
Hong
Zhi-Jian
ZJ
Wang
Xiu-Kun
XK
Wang
Jun
J
Hu
Xin-Bao
XB
D001165:Arteriovenous Malformations / Q000628:therapy*; D001761:Bleomycin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002408:Catheters, Indwelling; D002648:Child; D003300:Copper / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D055815:Young Adult
D001761:Bleomycin; C025703:bleomycetin; D003300:Copper