title: In vivo antimalarial activity of ethanolic leaf extract of Stachytarpheta cayennensis.
abstract: OBJECTIVE
  To evaluate the in vivo antiplasmodial activity of the ethanol leaf extract of Stachytarpheta cayennensis in the treatment of various ailment in Niger Delta region of Nigeria, in Plasmodium berghei infected mice.
  
  
  METHODS
  The ethanolic leaf extract of Stachytarpheta cayennensis (90-270 mg/kg/day) was screened for blood schizonticidal activity against chloroquine sensitive Plasmodium berghei berghei in mice. The schizonticidal effect during early and established infections was investigated.
  
  
  RESULTS
  Stachytarpheta cayennensis (90-270 mg/kg/day) exhibited significant (P< 0.05) blood schizonticidal activity both in 4-day early infection test and in established infection with a considerable mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day.
  
  
  CONCLUSIONS
  The leaf extract possesses significant (P< 0.05) antiplasmodial activity which confirms it's use in folkloric medicine in the treatment of malaria.
authors.forename: Jude E
authors.initials: JE
authors.lastname: Okokon
authors.forename: Ette
authors.initials: E
authors.lastname: Ettebong
authors.forename: Bassey S
authors.initials: BS
authors.lastname: Antia