Five year study of cardiovascular risk factors in Japanese people: implications concerning new onset of metabolic syndrome.
BACKGROUND
The incidence of metabolic syndrome (MetS) has not been fully studied.


RESULTS
The data of 35,534 subjects who underwent a health examination both in 1996 and 2001 were analyzed. Since the waist circumference was not available, modified criteria of MetS was used for those with 3 or more of the following items: 1) body mass index (BMI) >or=25 kg/m(2), 2) blood pressure >or=130 mm Hg in systolic and/or >or=85 mm Hg in diastolic, 3) triglycerides >or=150 mg/dL, 4) high-density lipoprotein (HDL) cholesterol <or=40 mg/dL in men, <or=50 mg/dL in women, and 5) fasting blood glucose (FBG) >or=100 mg/dL. The subjects who underwent therapy for hypertension, diabetes mellitus, and high TG were considered to have these items. The incidence of MetS over 5 years was determined and its risks were evaluated by Cox proportional-hazards models. During the follow-up of exactly 5 years, MetS developed in 2,853 (9.32%) among 30,623 subjects who had no MetS at baseline. The subjects who developed MetS were older, and had elevated BMI, blood pressure, TG and FBG (p<0.001 for all) and lower HDL (p<0.034 for men and p<0.001 for women). Each item of MetS and their combination was associated with a higher risk to develop MetS. Obesity (BMI >or=25 kg/m(2)) alone or in combination with another item was associated with a higher risk to develop MetS suggesting it plays a key role.


CONCLUSIONS
MetS using BMI developed in 9.32% over 5 years or 1.86%/year. Each item of MetS or their combination showed a high risk to develop MetS. Obesity was associated with a higher hazard ratio to develop MetS.
Suzuki
Akiko
A
Division of Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan.
Kosuge
Keiichiro
K
Nanyu
Osamu
O
Watanabe
Hiroshi
H
Watanabe
Toru
T
Usuda
Yoshimaru
Y
Sasaki
Shigeru
S
Aizawa
Yoshifusa
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D012307:Risk Factors; D055815:Young Adult