Cerebral microbleeds in predialysis patients with chronic kidney disease.
BACKGROUND
Gradient-echo T2*-weighted magnetic resonance imaging (T2*-weighted MRI) is highly sensitive for detecting cerebral microbleeds (CMBs). CMBs have been reported to be a risk factor for future cerebrovascular events and a marker of cerebral small vessel disease in the general population. Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease. The relationship between CKD and CMBs, which has not been clarified to date, is examined.


METHODS
In this cross-sectional study, T2*-weighted MRI of brain was performed with a 1.5-T MRI system in 162 CKD patients (CKD stages 1-5, excluding CKD stage 5(D)) and 24 normal subjects.


RESULTS
CMBs were found in 35 CKD patients (25.6%), but not in control subjects. CMBs were more prevalent in male patients, in those with higher blood pressure, advanced age and poor kidney function. There was a significant association between the prevalence of CMBs and the CKD stage, with higher prevalence of CMBs as the CKD stages advanced (P < 0.01). Estimated glomerular filtration rate was a significant factor associated with the prevalence of CMBs, independent of age, gender and hypertension. There was no significant relationship between CMBs and the presence of diabetes mellitus and dyslipidemia.


CONCLUSIONS
Decreased renal function is a significant risk factor for CMBs, independent of the presence of hypertension. Poor kidney function could be associated with future cerebrovascular events.
Shima
Hideaki
H
Department of Endocrinology, Metabolism and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
Ishimura
Eiji
E
Naganuma
Toshihide
T
Yamazaki
Takeshi
T
Kobayashi
Ikue
I
Shidara
Kaori
K
Mori
Katsuhito
K
Takemoto
Yoshiaki
Y
Shoji
Tetsuo
T
Inaba
Masaaki
M
Okamura
Mikio
M
Nakatani
Tatsuya
T
Nishizawa
Yoshiki
Y
D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects; D001794:Blood Pressure; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000209:etiology*; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000150:complications; D007674:Kidney Diseases / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D006435:Renal Dialysis
D000925:Anticoagulants