title: Decrease in antioxidant status of plasma and erythrocytes from patients with ankylosing spondylitis.
abstract: OBJECTIVE
  The aim of the study was to evaluate the antioxidant status in plasma and erythrocytes from patients with ankylosing spondylitis (AS).
  
  
  METHODS
  16 patients with AS and 16 healthy volunteers were involved in this study. Activities of antioxidant enzymes: superoxide dismutase (SOD) and its isoenzymes - (SOD-Mn) and (SOD-ZnCu), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione transferase (GST), as well as the total antioxidant status (TAS) and concentration of malondialdehyde (MDA) in plasma and/or erythrocytes, respectively were determined.
  
  
  RESULTS
  In patients with AS, a statistically significant decrease in plasma activity of SOD, SOD-CuZn and TAS, significant drop in activity of SOD, GPx, GST and GR in erythrocytes, as well as increased concentration of MDA in comparison with control group of healthy volunteers was observed.
  
  
  CONCLUSIONS
  Decrease in antioxidant status leading to generation of oxidative stress may play an important role in the pathogenesis of ankylosing spondylitis.
authors.affiliation: Department and Clinic of Internal Diseases, Angiology and Physical Medicine, Medical University of Silesia, 15 Batorego Street, 41-902 Bytom, Poland. astanek@tlen.pl
authors.forename: Agata
authors.initials: A
authors.lastname: Stanek
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Cieślar
authors.forename: Ewa
authors.initials: E
authors.lastname: Romuk
authors.forename: Sławomir
authors.initials: S
authors.lastname: Kasperczyk
authors.forename: Karolina
authors.initials: K
authors.lastname: Sieroń-Stołtny
authors.forename: Ewa
authors.initials: E
authors.lastname: Birkner
authors.forename: Aleksander
authors.initials: A
authors.lastname: Sieroń
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood / Q000378:metabolism; D015536:Down-Regulation; D004912:Erythrocytes / Q000737:chemistry / Q000378:metabolism*; D005978:Glutathione / Q000097:blood / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009088:Mucoproteins / Q000097:blood / Q000378:metabolism; D010949:Plasma / Q000737:chemistry / Q000378:metabolism*; D013167:Spondylitis, Ankylosing / Q000097:blood* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism
chemical_list: D000975:Antioxidants; D009088:Mucoproteins; D008315:Malondialdehyde; D002097:C-Reactive Protein; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione