title: Serum adiponectin acutely after an ischemic stroke: implications for a long-lasting, suppressed anti-inflammatory role.
abstract: OBJECTIVE
  Past ischemic stroke (IS) patients display suppressed adiponectin (ADPN) levels a few months after disease onset. It is still unclear whether hypoadiponectinemia is already present by the early stages of stroke or occurs as a delayed effect of the acute ischemic reaction. In the present study we investigated ADPN levels acutely after an IS.
  
  
  METHODS
  Serum ADPN was measured in 82 consecutive acute IS patients, and 30 stroke-free subjects of similar age and sex distributions.
  
  
  RESULTS
  Patients had significantly lower ADPN levels than controls. Higher ADPN was significantly associated with reduced odds for IS accounting for age, sex and high-density lipoproteins. This association was strengthened after further adjustments for potential confounders. ADPN levels remained suppressed even 6 months after stroke.
  
  
  CONCLUSIONS
  ADPN is significantly suppressed already by the early phases of stroke, and remains unchanged 6 months later. We propose a stable-over-time anti-inflammatory role of ADPN in IS, unrelated to the acute ischemic reaction.
authors.affiliation: Department of Neurology, University Hospital of Patras, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Marousi
authors.forename: G
authors.initials: G
authors.lastname: Theodorou
authors.forename: M
authors.initials: M
authors.lastname: Karakantza
authors.forename: P
authors.initials: P
authors.lastname: Papathanasopoulos
authors.forename: J
authors.initials: J
authors.lastname: Ellul
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D013997:Time Factors
chemical_list: D052242:Adiponectin; D000893:Anti-Inflammatory Agents