Inhibition of Porphyromonas gingivalis biofilm by oxantel.
Porphyromonas gingivalis is a major pathogen of chronic periodontitis and exists in a biofilm on the surface of the tooth root. Oxantel, a cholinergic anthelmintic and fumarate reductase inhibitor, significantly inhibited biofilm formation by P. gingivalis and disrupted established biofilms at concentrations below its MIC against planktonic cells. Oxantel was more effective against P. gingivalis in biofilm than metronidazole, a commonly used antibiotic for periodontitis.
Dashper
Stuart
S
Cooperative Research Centre for Oral Health Science, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Melbourne, Australia.
Ang
Ching-Seng
CS
Liu
Sze Wei
SW
Paolini
Rita
R
Veith
Paul
P
Reynolds
Eric
E
D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D008826:Microbial Sensitivity Tests; D018613:Microscopy, Confocal; D010518:Periodontitis / Q000382:microbiology; D010933:Plankton / Q000187:drug effects; D016966:Porphyromonas gingivalis / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D011715:Pyrantel / Q000031:analogs & derivatives* / Q000494:pharmacology; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors*
D011715:Pyrantel; C003407:oxantel; D013385:Succinate Dehydrogenase