Antimicrobial-resistant pathogens in animals and man: prescribing, practices and policies.
This meeting focused on infections in humans and animals due to methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum beta-lactamase (ESBL)-producing bacteria and Clostridium difficile, and their corresponding treatments. MRSA is predominantly a human pathogen, and molecular typing has revealed that certain clones have spread widely both between humans and from humans to animals. ESBL-producing bacteria, particularly those that express the CTX-M beta-lactamases, have been disseminated worldwide. Whilst such strains are usually isolated from humans, some animal isolates also produce CTX-M enzymes. In humans, one clone of CTX-M-producing Escherichia coli, sequence type (ST)131, has been particularly successful. C. difficile, often ribotype 027, commonly colonizes the hospital environment and causes serious infections in humans. In animals, ribotype 078 is more often found, and is an important cause of diarrhoea in piglets. There is a concern that the numbers of MRSA or other antimicrobial-resistant bacteria might increase further when human isolates become established in animals, as this can amplify the numbers of such bacteria by dissemination within animal groups with subsequent spread back to humans. Certain antimicrobials have been implicated in the selection of MRSA, ESBL-producing bacteria and predisposition to infection by C. difficile. Guidelines for treatment and prevention of infections by MRSA, ESBL-producing bacteria and C. difficile were discussed and evidence-based policies were recommended for both humans and animals.
Hunter
Pamela A
PA
Burnthouse, Burnthouse Lane, Cowfold, West Sussex RH13 8DH, UK.
Dawson
Susan
S
French
Gary L
GL
Goossens
Herman
H
Hawkey
Peter M
PM
Kuijper
Ed J
EJ
Nathwani
Dilip
D
Taylor
David J
DJ
Teale
Chris J
CJ
Warren
Rod E
RE
Wilcox
Mark H
MH
Woodford
Neil
N
Wulf
Mireille W
MW
Piddock
Laura J V
LJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology* / Q000662:veterinary*; D015373:Bacterial Typing Techniques; D016360:Clostridioides difficile / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D003015:Clostridium Infections / Q000188:drug therapy / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D004363:Drug Utilization; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000382:microbiology; D004926:Escherichia coli / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D006291:Health Policy; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D017720:Molecular Epidemiology; D055656:Prescriptions / Q000706:statistics & numerical data*; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D001618:beta-Lactamases / Q000096:biosynthesis
D000900:Anti-Bacterial Agents; D001618:beta-Lactamases