title: Study and description of hydrogels and organogels as vehicles for cosmetic active ingredients.
abstract: Cellulite, a clinical syndrome mainly affecting women, involves specific changes in conjunctive dermic and subcutaneous tissue, leading to vascular and hypertrophic alterations in adipose tissues and the consequent alteration of tissue structure. This paper describes the design of hydrogels and pluronic-lecithin organogels elaborated as vehicles of Aloe vera (Aloe vera linné) and Hydrocotyle asiatica (Centella asiatica) for the treatment of cellulite. The objective of this work was to carry out a complete evaluation of the proposed formulae through the study of the organoleptic and rheological properties of the formulae. Our work revealed that, in appearance, hydrogels show better organoleptic characteristics than organogels. On the other hand, from a rheological point of view, both hydrogels and organogels display a plastic behavior. However, the main difference between the two is that the more complex internal structure of the organogel bestows it with more viscosity. Finally, in vitro tests with Franz-type diffusion cells revealed that the release of cosmetic active principle from the tested excipients was appropriate, both in terms of magnitude and velocity.
authors.affiliation: Pharmacy and Pharmaceutical Technology Department, School of Pharmacy, University of Granada, 18071 Granada, Spain.
authors.forename: M E
authors.initials: ME
authors.lastname: Morales
authors.forename: V
authors.initials: V
authors.lastname: Gallardo
authors.forename: B
authors.initials: B
authors.lastname: Clarés
authors.forename: M B
authors.initials: MB
authors.lastname: García
authors.forename: M A
authors.initials: MA
authors.lastname: Ruiz
mesh_terms: D000287:Administration, Topical; D000504:Aloe / Q000737:chemistry; D028041:Centella / Q000737:chemistry*; D003358:Cosmetics / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D014677:Pharmaceutical Vehicles / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D020442:Poloxamer / Q000737:chemistry*; D012212:Rheology; D014783:Viscosity
chemical_list: D003358:Cosmetics; D020100:Hydrogels; D014677:Pharmaceutical Vehicles; D010936:Plant Extracts; D020442:Poloxamer