title: Asymmetric mannich reaction of malonates with imines catalyzed by a chiral calcium complex.
abstract: A chiral calcium complex was found to be effective for the Mannich reactions of malonates with N-Boc imines. The desired adducts were obtained in excellent yields (up to 95%) with moderate to good enantioselectivities (up to 77% ee).
authors.affiliation: Department of Chemistry, School of Science and Graduate School of Pharmaceutical Sciences, The University of Tokyo, The HFRE Division, ERATO, Japan Science and Technology Agency (JST), Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Thomas
authors.initials: T
authors.lastname: Poisson
authors.forename: Tetsu
authors.initials: T
authors.lastname: Tsubogo
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Shū
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D002118:Calcium / Q000737:chemistry*; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D008314:Malonates / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D007097:Imines; D008314:Malonates; D009942:Organometallic Compounds; D002118:Calcium