title: Prevalence of infection with porcine circovirus-2 (PCV-2) and porcine reproductive and respiratory syndrome virus (PRRSV) in an integrated swine production system experiencing postweaning multisystemic wasting syndrome.
abstract: The objective of this study was to evaluate the prevalence of infection with porcine circovirus-2 (PCV-2) and porcine reproductive and respiratory syndrome virus (PRRSV) through a longitudinal study in an integrated swine production system (7 farms) experiencing postweaning multisystemic wasting syndrome (PMWS). Risk factors for PCV-2 infection and for PCV-2 and PRRSV coinfection were also evaluated. Fifteen sows from each herd and 4 non-cross-fostered piglets from each sow were randomly selected at farrowing and ear-tagged at birth. Serum samples were analyzed for antibodies to PCV-2 and for detection of the PCV-2 and PRRSV genomes. Statistical analyses involved 2 approaches. The 1st approach characterized the dynamics of PCV-2 infection and their relationship with PRRSV infection. The 2nd approach analyzed the probability of being infected by PCV-2 or by both PCV-2 and PRRSV through a generalized linear mixed model incorporating sow and farm characteristics. At the 1st sampling time (1 wk of age), there was a significant relationship between sow PCV-2 infection and piglet PCV-2 infection (P < 0.0001). The risk of PCV-2 and PRRSV coinfection was 1.85 times greater in piglets from a sow with low titers of PCV-2 antibodies than in piglets from sows with medium to high titers (P = 0.03) and was 2.54, 2.40, and 2.02 times greater, respectively, in piglets from primiparous sows, PCV-2-infected sows, and farms in an area of high pig density than in piglets from sows of higher parity (P = 0.004), noninfected sows (P = 0.04), and farms in a low-density area (P = 0.09).
authors.affiliation: Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Campus de la Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. lorenzo.fraile@cresa.uab.es
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Fraile
authors.forename: Maria
authors.initials: M
authors.lastname: Calsamiglia
authors.forename: Enric
authors.initials: E
authors.lastname: Mateu
authors.forename: Anna
authors.initials: A
authors.lastname: Espinal
authors.forename: Anna
authors.initials: A
authors.lastname: Cuxart
authors.forename: Chiara
authors.initials: C
authors.lastname: Seminati
authors.forename: Marga
authors.initials: M
authors.lastname: Martín
authors.forename: Mariano
authors.initials: M
authors.lastname: Domingo
authors.forename: Joaquim
authors.initials: J
authors.lastname: Segalés
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000097:blood; D016009:Chi-Square Distribution; D018173:Circoviridae Infections / Q000453:epidemiology* / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D017925:Circovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D005260:Female; D007124:Immunoenzyme Techniques / Q000662:veterinary; D016014:Linear Models; D008137:Longitudinal Studies; D016133:Polymerase Chain Reaction / Q000662:veterinary; D053570:Porcine Postweaning Multisystemic Wasting Syndrome / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D019318:Porcine Reproductive and Respiratory Syndrome / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D019316:Porcine respiratory and reproductive syndrome virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D011247:Pregnancy; D015995:Prevalence; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics; D013552:Swine
chemical_list: D000914:Antibodies, Viral; D012367:RNA, Viral