DNA repair gene XRCC1 polymorphisms and outcome of renal cell carcinoma in Caucasian patients.
BACKGROUND
The human X-ray repair cross-complementing group 1 (XRCC1) enzyme plays an important role in response to DNA damage. Two common polymorphisms in XRCC1, Arg194Trp and Arg399Gln, have been repeatedly associated with risk for and outcome of numerous types of cancer treated with radio- and chemotherapy. Recently, a Japanese study suggested these polymorphisms both as risk factors and outcome predictors in renal cell carcinoma (RCC).


METHODS
In the present study, 142 Caucasian patients suffering from RCC were genotyped and analyzed for tumor-related and overall survival and time to metastasis and progression.


RESULTS
Analyses revealed absence of the pre-described risk haplotype (194Trp/399Gln) as well as a lack of a statistically significant difference between the different endpoints and genotypes and diplotypes, respectively.


CONCLUSIONS
We conclude that in Caucasian patients, XRCC1 polymorphisms do not influence the outcome of RCC.
Bachmann
Hagen S
HS
University Hospital Essen, Institute of Pharmacogenetics, Hufelandstrasse 55, 45147 Essen, Germany. hagen.bachmann@uk-essen.de
Rübben
Herbert
H
Schmid
Kurt W
KW
Siffert
Winfried
W
Riemann
Kathrin
K
D014408:Biomarkers, Tumor / Q000235:genetics*; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000556:secondary; D016022:Case-Control Studies; D004260:DNA Repair / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D005838:Genotype; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D015996:Survival Rate; D000076105:X-ray Repair Cross Complementing Protein 1
D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human