Maternal macronutrient and energy intakes in pregnancy and offspring intake at 10 y: exploring parental comparisons and prenatal effects.
BACKGROUND
High maternal dietary intakes in pregnancy may lead to increased fetal growth and program neuroendocrine pathways that result in greater appetite, energy intake, and adiposity in offspring later in life. Few prospective dietary studies have explored this relation.


OBJECTIVE
The objective was to assess associations of maternal dietary intake in pregnancy and maternal and paternal dietary intake postnatally with child dietary intake and adiposity.


METHODS
Dietary intakes of energy, protein, total fat, and carbohydrate were assessed prospectively in mothers during pregnancy, in mothers and their partners at 47 mo postnatally, and in children at 10 y (n = 5717 mother-child pairs prenatally, 5593 mother-child pairs postnatally, and 3009 father-child pairs). Child body composition was assessed at 9 and 11 y (n = 5725).


RESULTS
Maternal dietary intakes of protein, fat (when adjusted for energy intake), and carbohydrate in pregnancy were positively associated with child dietary intakes of the same nutrients, and these associations were greater than those observed for paternal dietary intake, which was not strongly associated with offspring diet. Associations of maternal prenatal-offspring intakes were stronger than those of maternal postnatal-offspring intakes for protein and fat. Greater child energy and macronutrient intakes were only associated with greater adiposity in children when adjusted for potential energy underreporting. Maternal diet during pregnancy was not associated with offspring adiposity or lean mass.


CONCLUSIONS
The stronger prenatal maternal associations with child dietary intake, particularly protein and fat, compared with both paternal intake associations and maternal postnatal intake associations provide some evidence for in utero programming of offspring appetite by maternal intake during pregnancy.
Brion
Marie-Jo A
MJ
Department of Social Medicine, University of Bristol, Bristol, UK. marie-jo.brion@bristol.ac.uk
Ness
Andy R
AR
Rogers
Imogen
I
Emmett
Pauline
P
Cribb
Victoria
V
Davey Smith
George
G
Lawlor
Debbie A
DA
D050154:Adiposity; D001066:Appetite; D001823:Body Composition; D001835:Body Weight; D002648:Child; D004032:Diet; D002149:Energy Intake; D005220:Fathers; D005260:Female; D006801:Humans; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D018977:Micronutrients / Q000008:administration & dosage; D009035:Mothers; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena; D011446:Prospective Studies; D012907:Smoking / Q000453:epidemiology; D011795:Surveys and Questionnaires
D018977:Micronutrients