Thyroid-type solid cell nests in struma ovarii.
Solid cell nests (SCNs) of the thyroid are single or multiple foci of solid and/or cystic clusters of squamoid cells (main cells) with a minor proportion of C-cells, found in the normal thyroid. The SCNs have also been reported in the heart as an ultimobranchial heterotopia. Here, the authors describe a case of thyroid-type SCNs associated with struma ovarii. Main cells were positive for simple and stratified epithelial-type cytokeratins, carcinoembryonic antigen, carbohydrate antigen 19.9, p63, bcl-2, and galectin-3. The neuroendocrine cell population was positive for chromogranin A and synaptophysin but negative for calcitonin, suggesting a common ancestor cell capable of dual differentiation toward thyroid follicular cells and hindgut-type endocrine cells. The existence of thyroid-type SCNs in struma ovarii could be easily understood by considering the struma ovarii as a teratoma; at the same time, these findings also support the idea of a close histogenetic link between the main cells of SCNs and thyroid tissue.
Cameselle-Teijeiro
José
J
Hospital Clínico Universitario, Galician Health Service, University of Santiago de Compostela, Galicia, Spain. josemanuel.cameselle@usc.es
Caramés
Nuria
N
Romero-Rojas
Alfredo
A
Reyes-Santías
Rosa
R
Piso-Neira
Magalí
M
Bernabeu
Ignacio
I
Abdulkader
Ihab
I
D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D013330:Struma Ovarii / Q000378:metabolism / Q000473:pathology*