title: Aberrant Ca2+ handling in lysosomal storage disorders.
abstract: Lysosomal storage diseases (LSDs) are caused by inability of cells to process the material captured during endocytosis. While they are essentially diseases of cellular "indigestion", LSDs affect large number of cellular activities and, as such, they teach us about the integrative function of the cell, as well as about the gaps in our knowledge of the endocytic pathway and membrane transport. The present review summarizes recent findings on Ca2+ handling in LSDs and attempts to identify the key questions on alterations in Ca2+ signaling and membrane transport in this group of diseases, answers to which may lie in delineating the cellular pathogeneses of LSDs.
authors.affiliation: Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA. Kiselyov@pitt.edu
authors.forename: Kirill
authors.initials: K
authors.lastname: Kiselyov
authors.forename: Soichiro
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Lyons
authors.forename: Shmuel
authors.initials: S
authors.lastname: Muallem
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D004705:Endocytosis; D006801:Humans; D016464:Lysosomal Storage Diseases / Q000235:genetics / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism*; D026901:Membrane Transport Proteins; D008928:Mitochondria / Q000378:metabolism*
chemical_list: D026901:Membrane Transport Proteins