New data on the clinical impact of exercise training, fish oils, and statins in heart failure.
Despite major advances in the field of cardiovascular (CV) diseases, heart failure (HF) continues to result in considerable CV morbidity and mortality and accounts for an increasing number of acute hospitalizations in adult patients. Recent major trials have focused on exercise training programs and the widely available nutraceutical omega-3 polyunsaturated fatty acids or fish oil and statins in patients with HF. In this article, we provide insight into the interpretation of the evidence base for these distinct interventions in HF and provide guidance for the clinical incorporation of exercise training and fish oil therapy for additional CV protection in chronic HF.
Lavie
Carl J
CJ
Department of Cardiovascular Diseases, Ochsner Medical Center, 1514 Jefferson Highway, New Orleans, LA 70121-2483, USA. clavie@ochsner.org
O'Keefe
James H
JH
Milani
Richard V
RV
Ventura
Hector O
HO
Mehra
Mandeep R
MR
D000818:Animals; D005081:Exercise Therapy / Q000379:methods*; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D005395:Fish Oils / Q000494:pharmacology*; D006333:Heart Failure / Q000517:prevention & control*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*
D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors