Thyroid hormone prevents cognitive deficit in a mouse model of Alzheimer's disease.
This study aimed to examine the feasibility of using thyroid hormone (TH) as a therapeutic agent for Alzheimer's disease (AD). Mice were injected intra-hippocampally aggregated amyloid beta-peptide (Abeta) to produce AD animal model. Intraperitoneal administration of l-thyroxine (L-T4) into Abeta-induced AD model mice prevented their cognitive impairment and improved their memory function. The mechanisms of L-T4 treating AD might be associated with regulating cholinergic function, protecting the brains of AD model mice against damage from free radicals, and rescuing hippocampal neurons from apoptosis. The results of the present study indicate that the use of TH has some therapeutic potential in AD.
Fu
Ai Ling
AL
School of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China. Fuailing1008@yahoo.com.cn
Zhou
Cheng Yu
CY
Chen
Xiang
X
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D000818:Animals; D003072:Cognition Disorders / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D005240:Feasibility Studies; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D013974:Thyroxine / Q000494:pharmacology / Q000627:therapeutic use*
D013974:Thyroxine