title: Granulosa cell tumor of the broad ligament: report of a case with emphasis on the differential diagnosis with female adnexal tumor of probable Wolffian origin.
abstract: This is a report of a paratubal adult granulosa cell tumor (GCT) located within the right broad ligament in a 62-year-old woman. These are rare tumors with only 8 cases reported so far. Because of an overlap of topographic, morphologic, and immunohistochemical features, it is not always possible to differentiate between the broad ligament GCT and female adnexal tumor of probable Wolffian origin (FATWO). Although nuclear grooving is not an exclusive feature of GCT and can be seen in a variety of other neoplasms, in the context of the differential diagnosis between broad ligament GCT and FATWO, the presence of this feature may be very useful in establishing the diagnosis of broad ligament GCT.
authors.affiliation: Patho-Lab Diagnostics, Ness Ziona, Israel. bc@patho-lab.com
authors.forename: Bernard
authors.initials: B
authors.lastname: Czernobilsky
authors.forename: Beatriz
authors.initials: B
authors.lastname: Lifschitz-Mercer
authors.forename: Leonor
authors.initials: L
authors.lastname: Trejo
authors.forename: Ilan
authors.initials: I
authors.lastname: Atlas
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001956:Broad Ligament / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002467:Cell Nucleus / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005833:Genital Neoplasms, Female / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D006106:Granulosa Cell Tumor / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D018294:Neoplasms, Adnexal and Skin Appendage / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D016896:Treatment Outcome; D014928:Wolffian Ducts / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor