Regulation of immunity and oncogenesis by the IRF transcription factor family.
Nine interferon regulatory factors (IRFs) compose a family of transcription factors in mammals. Although this family was originally identified in the context of the type I interferon system, subsequent studies have revealed much broader functions performed by IRF members in host defense. In this review, we provide an update on the current knowledge of their roles in immune responses, immune cell development, and regulation of oncogenesis.
Savitsky
David
D
Department of Immunology, Faculty of Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
Tamura
Tomohiko
T
Yanai
Hideyuki
H
Taniguchi
Tadatsugu
T
D000818:Animals; D006801:Humans; D007109:Immunity / Q000502:physiology*; D050835:Interferon Regulatory Factors / Q000502:physiology*; D009369:Neoplasms / Q000378:metabolism*
D050835:Interferon Regulatory Factors