title: Body fat distribution has no effect on serum visfatin levels in healthy female subjects.
abstract: Obesity is the presence of either abnormal absolute amount or relative proportion of body fat. Contrary to gluteal obesity, visceral obesity is associated with different metabolic alterations including insulin resistance (IR). A relatively new adipocytokine visfatin is shown to be expressed predominantly in visceral fat and exhibit insulin-mimicking effects in rodents. It is still unclear whether serum visfatin levels are associated with increased total or visceral fat mass in humans. The aim of our study was to investigate the relation between visfatin and obesity parameters namely body mass index (BMI) and waist circumference (WaC) and IR in healthy female subjects. Eighty one female subjects 20 years of age, having no diagnosis of glucose intolerance or diabetes, hypertension and dyslipidemia were chosen. The patients were divided into four groups according to their BMI and WaC values. Serum visfatin and HOMA-IR levels did not differ among groups. No correlation was detected between serum visfatin levels and obesity and metabolic parameters. In conclusion, we demonstrated that body fat distribution did not affect serum visfatin levels in healthy female subjects. Further studies are needed to clarify the exact factors influencing and determining serum visfatin levels and its clinical reflections.
authors.affiliation: Department of Internal Medicine, Uludag University Medical School, Bursa, Turkey. ecanan@uludag.edu.tr
authors.forename: Canan
authors.initials: C
authors.lastname: Ersoy
authors.forename: Ganime
authors.initials: G
authors.lastname: Sadikoglu
authors.forename: Hasan
authors.initials: H
authors.lastname: Orhan
authors.forename: Metin
authors.initials: M
authors.lastname: Guclu
authors.forename: Emre
authors.initials: E
authors.lastname: Sarandol
authors.forename: Meral Demirci
authors.initials: MD
authors.lastname: Akgun
authors.forename: Alis
authors.initials: A
authors.lastname: Ozcakir
authors.forename: Sazi
authors.initials: S
authors.lastname: Imamoglu
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D050218:Body Fat Distribution; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000378:metabolism; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D009765:Obesity / Q000097:blood; D011446:Prospective Studies; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D007328:Insulin; D054409:Nicotinamide Phosphoribosyltransferase