NFATc1: functions in osteoclasts.
NFATc1 is an important transcription factor which is critical for lineage selection in T-cell differentiation, cardiac valve morphogenesis, lymphatic endothelial development, osteoblast differentiation and osteoclastogenesis. Especially, it is a master regulator of RANKL-induced osteoclast differentiation and plays a pivotal role in osteoclast fusion and osteoclast activation via up-regulation of various genes responsible for osteoclast adhesion, migration, acidification, degradation of inorganic and organic bone matrix. In the present review, some of the known features of NFATc1 such as structure, function and its roles in physiological or pathophysiological processes are highlighted.
Zhao
Qingxiao
Q
College of Chemical Engineering, Northeast Dianli University, Changchun Road 169, Jilin, PR China. zhaoqingxiao@163.com
Wang
Xi
X
Liu
Yuehua
Y
He
Aimin
A
Jia
Ruokun
R
D000818:Animals; D001862:Bone Resorption / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D020013:Calcium Signaling; D002448:Cell Adhesion / Q000235:genetics; D002454:Cell Differentiation / Q000187:drug effects; D002459:Cell Fusion; D002465:Cell Movement / Q000235:genetics; D006801:Humans; D050778:NFATC Transcription Factors / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D053245:RANK Ligand / Q000378:metabolism; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000378:metabolism; D015854:Up-Regulation
D050778:NFATC Transcription Factors; C494003:NFATC1 protein, human; C494005:Nfatc1 protein, mouse; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B