title: An evaluation of the genotoxic and cytotoxic effects of the anti-obesity drugs sibutramine and fenproporex.
abstract: Anti-obesity medications deserve special considerations at the present time due to an increasing number of overweight and obese people who require these therapeutic alternatives. Obesity is positively associated with several chronic illnesses, including cancer. In this work, we evaluated the possible genotoxic and/or cytotoxic actions of two drugs, sibutramine and fenproporex, in the doses of 10, 20 and 40 mg/kg body weight (bw), administered intraperitoneally in male Swiss mice. The genotoxic effect was analyzed by comet assay and micronucleus test. We found that both drugs increased the frequency of genotoxic damage in Swiss mice, but did not present cytotoxic activities towards the polychromatic erythrocytes of the bone marrow of these animals.
authors.affiliation: Department of Genetics, Faculty of Medicine of Ribeirão Preto, São Paulo University, São Paulo, Brazil. profeta@usp.br
authors.forename: Cristiano José
authors.initials: CJ
authors.lastname: da Silva
authors.forename: José Ernesto
authors.initials: JE
authors.lastname: dos Santos
authors.forename: Catarina
authors.initials: C
authors.lastname: Satie Takahashi
mesh_terms: D000662:Amphetamines / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000633:toxicity*; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000473:pathology; D020552:Comet Assay; D003503:Cyclobutanes / Q000008:administration & dosage / Q000633:toxicity*; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced*; D018570:Risk Assessment
chemical_list: D000662:Amphetamines; D019440:Anti-Obesity Agents; D003503:Cyclobutanes; C026013:fenproporex; C058254:sibutramine