title: Heavy ions, radioprotectors and genomic instability: implications for human space exploration.
abstract: The risk associated with space radiation exposure is unique from terrestrial radiation exposures due to differences in radiation quality, including linear energy transfer (LET). Both high- and low-LET radiations are capable of inducing genomic instability in mammalian cells, and this instability is thought to be a driving force underlying radiation carcinogenesis. Unfortunately, during space exploration, flight crews cannot entirely avoid radiation exposure. As a result, chemical and biological countermeasures will be an important component of successful extended missions such as the exploration of Mars. There are currently several radioprotective agents (radioprotectors) in use; however, scientists continue to search for ideal radioprotective compounds-safe to use and effective in preventing and/or reducing acute and delayed effects of irradiation. This review discusses the agents that are currently available or being evaluated for their potential as radioprotectors. Further, this review discusses some implications of radioprotection for the induction and/or propagation of genomic instability in the progeny of irradiated cells.
authors.affiliation: Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA.
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Dziegielewski
authors.forename: Wilfried
authors.initials: W
authors.lastname: Goetz
authors.forename: Janet E
authors.initials: JE
authors.lastname: Baulch
mesh_terms: D000818:Animals; D004781:Environmental Exposure / Q000009:adverse effects; D044127:Epigenesis, Genetic / Q000187:drug effects / Q000528:radiation effects; D042822:Genomic Instability / Q000187:drug effects* / Q000528:radiation effects*; D020450:Heavy Ions / Q000009:adverse effects*; D006801:Humans; D018499:Linear Energy Transfer; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D018570:Risk Assessment; D013026:Space Flight
chemical_list: D011837:Radiation-Protective Agents