Clinical biomarkers in hepatocellular carcinoma (HCC).
The Authors make a review of the most important molecules used today for detecting and screening hepatocellular carcinoma, analyzing their known biological features, advantages and limits especially concerning differential diagnosis from cirrhosis and others diseases. AFP, AFP-L3, DCP, Alpha-1-fucosidase are analyzed and all the current knowledge reviewed, as well as focusing on possible future applications and results of combined determination (what about another word here: evaluation etc) in HCC. Additionally other more recent molecules showing promising future clinical application are cited.
Donati
Marcello
M
Surgical Sciences, Organ Transplantations and New Technologies Department, General and Week Surgery OU University Hospital of Catania, Via S Sofia No 78, 95125 Catania, Italy. mar_donati@yahoo.it
Brancato
Giovanna
G
Donati
Angelo
A
D015415:Biomarkers / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000378:metabolism*; D053673:Glypicans / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D037121:Plant Lectins / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism; D011516:Prothrombin / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000378:metabolism; D005644:alpha-L-Fucosidase / Q000378:metabolism
C097353:AFP protein, human; D015415:Biomarkers; D014408:Biomarkers, Tumor; D053673:Glypicans; D037121:Plant Lectins; D011498:Protein Precursors; D000509:alpha-Fetoproteins; C033619:lentil lectin; C008208:acarboxyprothrombin; D011516:Prothrombin; D005644:alpha-L-Fucosidase