Potent transglutaminase inhibitors, aryl beta-aminoethyl ketones.
Aryl beta-aminoethyl ketones were discovered as potent inhibitors of tissue transglutaminase. Heteroaryl-like thiophene groups and N-benzyl N-t-butyl aminoethyl group are critical to the strong inhibitory activity of aryl beta-aminoethyl ketones.
Ozaki
Shoichiro
S
Laboratory for Developmental Neurobiology, Brain Science Institute, Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Ebisui
Etsuko
E
Hamada
Kozo
K
Goto
Jun-Ichi
J
Suzuki
Akinobu Z
AZ
Terauchi
Akiko
A
Mikoshiba
Katsuhiko
K
D000818:Animals; D006168:Guinea Pigs; D007659:Ketones / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D011503:Transglutaminases / Q000037:antagonists & inhibitors* / Q000378:metabolism
D007659:Ketones; D011503:Transglutaminases