title: Mechanism of inactivation of murine norovirus-1 by high pressure processing.
abstract: Murine norovirus-1 (MNV) is currently the most suitable surrogate for human norovirus. The mechanism of MNV-1 inactivation by high pressure processing (HPP) was investigated. HPP-treated MNV could not bind to its target receptor and therefore could not initiate infection of mouse RAW cells. The integrity of the capsid was not affect by HPP. Partial motif changes of the viral capsid caused by HPP were accessed by induced sensitivity to proteinase K.
authors.affiliation: College of Food Science and Engineering, Ocean University of China, No 5, Yushan Road, Qingdao, Shandong Province 266003, PR China.
authors.forename: Qingjuan
authors.initials: Q
authors.lastname: Tang
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Yuran
authors.initials: Y
authors.lastname: Zhao
authors.forename: Zhaojie
authors.initials: Z
authors.lastname: Li
authors.forename: Changhu
authors.initials: C
authors.lastname: Xue
mesh_terms: D000818:Animals; D002460:Cell Line; D019286:Endopeptidase K / Q000378:metabolism; D006874:Hydrostatic Pressure; D008264:Macrophages / Q000821:virology; D051379:Mice; D050296:Microbial Viability; D029322:Norovirus / Q000502:physiology*; D014764:Viral Proteins / Q000378:metabolism; D038301:Virus Inactivation
chemical_list: D014764:Viral Proteins; D019286:Endopeptidase K