The association between eNOS intron 4 VNTR polymorphism and delayed graft function of kidney allografts.
Nitric oxide (NO) is a multifunctional agent which serves as a key signaling molecule in physiological processes such as host defense, neuronal communication, and the regulation of vascular tone. Different polymorphic variations have been identified in the human NOS3 (eNOS) gene.The aim of the present study was to examine the association between polymorphisms of the NOS3 gene (G894T substitution within exon 7 and intron 4 VNTR polymorphism) and the development of delayed graft function as well as acute and chronic rejection.One hundred eighty-seven recipients of first renal transplants were included in the study. There were no significant associations between these polymorphisms and acute and chronic kidney allograft rejection. The intron 4 polymorphism was associated with delayed graft function after transplantation. The results of this study suggest that patients with the a allele of the eNOS intron 4 VNTR polymorphism may be predisposed to delayed graft function.
Dutkiewicz
Grażyna
G
Department of Nephrology, Transplantology, and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
Domanski
Leszek
L
Binczak-Kuleta
Agnieszka
A
Pawlik
Andrzej
A
Safranow
Krzysztof
K
Ciechanowicz
Andrzej
A
Dziedziejko
Violetta
V
Ciechanowski
Kazimierz
K
D000328:Adult; D000483:Alleles; D051799:Delayed Graft Function / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D012189:Retrospective Studies; D014184:Transplantation, Homologous
C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III