title: Tuberculosis research: going forward with a powerful "translational systems biology" approach.
abstract: Due to the complexity of the immune response to a Mycobacterium tuberculosis infection, identifying new, effective therapies and vaccines to combat it has been a problematic issue. Although many advances have been made in understanding particular mechanisms involved, they have, to date, proved insufficient to provide real breakthroughs in this area of tuberculosis research. The term "Translational Systems Biology" has been formally proposed to describe the use of experimental findings combined with mathematical modeling and/or engineering principles to understand complex biological processes in an integrative fashion for the purpose of enhancing clinical practice. This opinion piece discusses the importance of using a Translational Systems Biology approach for tuberculosis research as a means by which to go forward with the potential for significant breakthroughs to occur.
authors.affiliation: Mathematical Biosciences Institute, The Ohio State University, Jennings Hall, 3rd Floor, 1735 Neil Ave, Columbus, OH 43210, USA. jday@mbi.osu.edu <jday@mbi.osu.edu>
authors.forename: Judy
authors.initials: J
authors.lastname: Day
authors.forename: Larry S
authors.initials: LS
authors.lastname: Schlesinger
authors.forename: Avner
authors.initials: A
authors.lastname: Friedman
mesh_terms: D006801:Humans; D008962:Models, Theoretical; D049490:Systems Biology; D057170:Translational Research, Biomedical; D014376:Tuberculosis / Q000188:drug therapy / Q000517:prevention & control