title: Parkinson's disease spatial covariance pattern: noninvasive quantification with perfusion MRI.
abstract: Parkinson's disease (PD) is associated with elevated expression of a specific disease-related spatial covariance pattern (PDRP) in radiotracer scans of cerebral blood flow and metabolism. In this study, we scanned nine early-stage patients with PD and nine healthy controls using continuous arterial spin labeling (CASL) perfusion magnetic resonance imaging (pMRI). Parkinson's disease-related metabolic pattern expression in CASL pMRI scans was compared with the corresponding (18)F-fluorodeoxyglucose positron emission tomography values. The PDRP expression was abnormally elevated (P<0.01) in patients scanned with either modality, and the two values were highly intercorrelated (P<0.0001). Perfusion MRI methods can be used for accurate quantification of disease-related covariance patterns.
authors.affiliation: Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA.
authors.forename: Yilong
authors.initials: Y
authors.lastname: Ma
authors.forename: Chaorui
authors.initials: C
authors.lastname: Huang
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Dyke
authors.forename: Hong
authors.initials: H
authors.lastname: Pan
authors.forename: David
authors.initials: D
authors.lastname: Alsop
authors.forename: Andrew
authors.initials: A
authors.lastname: Feigin
authors.forename: David
authors.initials: D
authors.lastname: Eidelberg
mesh_terms: D000368:Aged; D001923:Brain Chemistry / Q000502:physiology; D002560:Cerebrovascular Circulation; D003627:Data Interpretation, Statistical; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000473:pathology*; D010865:Pilot Projects; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18