title: [A long term survivor of advanced gastric cancer treated with multi-drug combination chemotherapy].
abstract: We report a case of 70-year-old man who was admitted to our hospital due to hematemesis in June 2004. He was diagnosed by gastroscopy as having a type III moderately-poorly differentiated adenocarcinoma. A computed tomography (CT) scan revealed multiple lymph nodes swelling (#13, #16), finally he was diagnosed with gastric cancer stage IV (cT3, cN3, cM1). He was treated with S-1, but lymph nodes swelling increased in size, and then in March 2005, the treatment was changed to a second-line chemotherapy consisting of CPT-11 and CDDP. Abdominal CT scan showed a remarkable reduction of #16b1 lymph node, and the second-line chemotherapy was continued until 23 courses. But in April 2007, gastroscopy revealed the enlargement of gastric lesion. He was treated by third-line chemotherapy consisting of paclitaxel and doxifluoridine. This therapy was effective and continued until 7 courses. However, the treatment gradually became resistant and he died in May 2008, which was 4 years since the initial diagnosis.
authors.affiliation: Department of Gastroenterology, Rumoi Municipal Hospital.
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Takanashi
authors.forename: Shinya
authors.initials: S
authors.lastname: Minami
authors.forename: Naoya
authors.initials: N
authors.lastname: Miyajima
authors.forename: Tasuku
authors.initials: T
authors.lastname: Hirako
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hirakawa
authors.forename: Yutaku
authors.initials: Y
authors.lastname: Koh
authors.forename: Tadanori
authors.initials: T
authors.lastname: Saitoh
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ueno
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sasagawa
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D002945:Cisplatin / Q000008:administration & dosage; D005467:Floxuridine / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D005467:Floxuridine; D000077146:Irinotecan; D017239:Paclitaxel; D002945:Cisplatin; C025034:doxifluridine; D002166:Camptothecin