Molecular mechanisms of allorecognition in a basal chordate.
Allorecognition has been described in many metazoan phyla, from the sponges to the mammals. In vertebrates, allorecognition is a result of a MHC-based recognition event central to adaptive immunity. However, the origin of the adaptive immune system and the potential relationship to more primitive allorecognition systems is unclear. The colonial ascidian, Botryllus schlosseri, has been used as a model organism for the study of allorecognition for over a century, as it undergoes a natural transplantation reaction controlled by a single, highly polymorphic locus. Herein we will summarize our current understanding of the molecular mechanisms that underlie this innate allorecognition reaction.
McKitrick
Tanya R
TR
Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
De Tomaso
Anthony W
AW
D000818:Animals; D015551:Autoimmunity; D006801:Humans; D007113:Immunity, Innate; D018448:Models, Immunological; D010641:Phenotype; D014561:Urochordata / Q000276:immunology*