title: Leaping forks at inverted repeats.
abstract: Genome rearrangements are often associated with genome instability observed in cancer and other pathological disorders. Different types of repeat elements are common in genomes and are prone to instability. S-phase checkpoints, recombination, and telomere maintenance pathways have been implicated in suppressing chromosome rearrangements, but little is known about the molecular mechanisms and the chromosome intermediates generating such genome-wide instability. In the December 15, 2009, issue of Genes & Development, two studies by Paek and colleagues (2861-2875) and Mizuno and colleagues (pp. 2876-2886), demonstrate that nearby inverted repeats in budding and fission yeasts recombine spontaneously and frequently to form dicentric and acentric chromosomes. The recombination mechanism underlying this phenomenon does not appear to require double-strand break formation, and is likely caused by a replication mechanism involving template switching.
authors.affiliation: Fondazione IFOM, Istituto FIRC di Oncologia Molecolare, 20139 Milan, Italy. dana.branzei@ifom-ieo-campus.it
authors.forename: Dana
authors.initials: D
authors.lastname: Branzei
authors.forename: Marco
authors.initials: M
authors.lastname: Foiani
mesh_terms: D043171:Chromosomal Instability / Q000235:genetics*; D015825:Chromosomes, Fungal / Q000235:genetics; D053903:DNA Breaks, Double-Stranded; D004261:DNA Replication / Q000235:genetics; D015321:Gene Rearrangement / Q000235:genetics; D055029:Inverted Repeat Sequences / Q000235:genetics*; D008957:Models, Genetic; D011995:Recombination, Genetic / Q000235:genetics*; D004718:Saccharomycetales / Q000235:genetics*; D012568:Schizosaccharomyces / Q000235:genetics*