title: Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography.
abstract: To assess the feasibility of small soft tissue avascular tumor micro-CT imaging with x-ray phase-contrast in-line holography, we have studied micro-CT imaging with in-line geometry of small spheroidal avascular tumor models with quiescent cell core (< 250 mum) and various distributions of the proliferating cell density (PCD) forming the outer shell. We have simulated imaging with an ultrafast laser-based x-ray source with a Mo target. We observe phase-contrast enhancement of the tumor boundaries in the reconstructed transaxial images, resulting in improved detection of small soft tissue tumors, providing that the PCD density gradient is sufficiently large.
authors.affiliation: CSIRO Manufacturing and Materials Technology, Clayton South, VIC, Australia, 3169.
authors.forename: Yakov
authors.initials: Y
authors.lastname: Nesterets
authors.forename: Tim
authors.initials: T
authors.lastname: Gureyev
authors.forename: Andrew
authors.initials: A
authors.lastname: Stevenson
authors.forename: Andrew
authors.initials: A
authors.lastname: Pogany
authors.forename: Steve
authors.initials: S
authors.lastname: Wilkins
authors.forename: Russell
authors.initials: R
authors.lastname: Kincaid
authors.forename: Hongwei
authors.initials: H
authors.lastname: Ye
authors.forename: Levon
authors.initials: L
authors.lastname: Vogelsang
authors.forename: Edward
authors.initials: E
authors.lastname: Lipson
authors.forename: Ioana
authors.initials: I
authors.lastname: Coman
authors.forename: Sylvain
authors.initials: S
authors.lastname: Fourmaux
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Kieffer
authors.forename: Andrzej
authors.initials: A
authors.lastname: Krol