Sonochemical stabilization of ultrafine colloidal biocompatible magnetite nanoparticles using amino acid, L-arginine, for possible bio applications.
Materials obtained by the synergistic combination of nanotechnology and biomedicine are an important source of drug delivery and other health care related applications. The anchoring of amino acids onto the surface of nano-sized magnetite is one such example. Herein, we report on the binding of a semi-essential amino acid, L-arginine, onto the surface of nano magnetite, creating a stable aqueous suspension by an in situ one-step method using sonochemical synthesis. An ex situ two-step process was also attempted, but was soon discarded owing to the relative short duration of the suspension attributed to increase in particle size and lower extent of binding. The initial concentration of the amino acid was found to play an important role in controlling the particle size and also the binding motif. Lower concentrations of arginine were found to favor the formation of elongated tubular structures, while at higher concentrations, the elongated structures were less prominent and arginine was found to be adsorbed onto the surface of the magnetite. This surface-functionalized nanomagnetite with amino acids could become a promising vehicle for drug delivery.
Theerdhala
Sriharsha
S
Department of Metallurgical Engineering and Materials Science, Indian Institute of Technology, Bombay, Mumbai 400 076, India.
Bahadur
Dhirendra
D
Vitta
Satish
S
Perkas
Nina
N
Zhong
Ziyi
Z
Gedanken
Aharon
A
D000042:Absorption; D001120:Arginine / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D003102:Colloids; D004337:Drug Carriers / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D008027:Light; D008280:Magnetics; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D012542:Scattering, Radiation; D017550:Spectroscopy, Fourier Transform Infrared; D013535:Suspensions; D014465:Ultrasonics; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D003102:Colloids; D004337:Drug Carriers; D013535:Suspensions; D001120:Arginine; D052203:Ferrosoferric Oxide