title: A phosphine-mediated construction of 1,4-oxazepines and 1,3-oxazines.
abstract: A simple and efficient method for constructing 1,4-oxazepines and 1,3-oxazines was developed with use of a phosphine-mediated tandem reaction of ynones with 2-azido alcohols. The method offers a promising route to synthetically useful as well as biologically active heterocycles under mild conditions and may be exploited for the preparation of interesting chiral ligands.
authors.affiliation: CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, Gif sur Yvette, F-91191, France.
authors.forename: Céline
authors.initials: C
authors.lastname: François-Endelmond
authors.forename: Thomas
authors.initials: T
authors.lastname: Carlin
authors.forename: Pierre
authors.initials: P
authors.lastname: Thuery
authors.forename: Olivier
authors.initials: O
authors.lastname: Loreau
authors.forename: Frédéric
authors.initials: F
authors.lastname: Taran
mesh_terms: D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010077:Oxazepines / Q000138:chemical synthesis* / Q000737:chemistry; D010078:Oxazines / Q000138:chemical synthesis* / Q000737:chemistry; D010720:Phosphines / Q000737:chemistry*
chemical_list: D010077:Oxazepines; D010078:Oxazines; D010720:Phosphines; C044646:phosphine