Polyunsaturated fatty acids and cardiovascular disease.
Several observational and experimental studies show the beneficial effects of omega-3 poly-unsaturated fatty acids (PUFA) in cardiovascular disease. The results from such studies justify supplementation of omega-3 PUFA in primary and secondary prevention of several clinical conditions, including coronary heart disease, sudden cardiac death and heart failure. Supplementation of omega-3 PUFA is also indicated as monotherapy in the treatment of hypertriglyceridemia. Analysis of their biological actions suggests a variety of anti-arrhythmic, anti-thrombotic, anti-atherosclerotic and anti-inflammatory mechanisms underlying their clinical benefits.
Calzolari
Ivan
I
Department of Critical Care Medicine and Surgery, Unit of Gerontology and Geriatrics, University of Florence and Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Fumagalli
Stefano
S
Marchionni
Niccolò
N
Di Bari
Mauro
M
D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000517:prevention & control*; D004032:Diet; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005399:Fishes; D006801:Humans
D015525:Fatty Acids, Omega-3