The effect of geometric shape on the release properties of metronidazole from lipid matrix tablets.
In this study, the lipophilic matrix tablets of metronidazole were prepared with Cutina HR (hydrogenated castor oil), stearic acid, Compritol ATO 888 (glyceryl behenate) and Precirol ATO 5 (glycerol palmitostearate) in two different shapes; cylinder and hexagonal. Our first aim was to investigate the influence of the lipid excipients and geometric shape on the release behavior of metronidazole, and the second aim was to investigate the influence of tablet surface area/volume (SA/V) ratio on drug release from controlled release matrix tablets. In vitro release test was performed using a standard USP dissolution apparatus I. Hardness, surface/volume ratio and friability were determined. The hexagonal tablets were harder than the cylinder tablets. Stearic acid showed the highest release rates for both geometric shapes reflecting the highest surface area and the lowest SA/V ratio. According to power law analysis, the diffusion mechanism was expressed as a Fickian diffusion for all lipid matrix tablets. The square root of time relationship was operative for all tablets. Higuchi kinetic constants obtained with hexagonal tablets were higher than the cylinder tablets. As the type of lipid matrix, the geometric shape of the tablets was also effective on the diffusion and release kinetics. From the present study, it was shown that surface area and volume ratio may be used as parameters for the evaluation of the drug release profile.
Gökçe
Evren H
EH
University of Ege, Faculty of Pharmacy, Department of Pharmaceutical Technology 35100 Bornova, Izmir, Turkey.
Ozyazici
Mine
M
Ertan
Gokhan
G
D001826:Body Fluids / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008795:Metronidazole / Q000737:chemistry*; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D013499:Surface Properties
D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes; D046911:Macromolecular Substances; D008795:Metronidazole