[Metformin-associated hepatotoxicity].
Metformin is an oral biguanide widely used in the management of patients with type 2 diabetes. It produces non-specific gastrointestinal symptoms in 10-30% of the patients. Lactic acidosis is the most serious side effect, so it must not be administered to patients with renal, liver, or heart insufficiency. Only a few cases of hepatotoxicity due to this drug have been documented. We report the case of a patient with type 2 diabetes mellitus and recent use of metformin who developed serious liver injury, followed by a favorable evolution.
Olivera-González
S
S
Servicio de Medicina Interna, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España. susana.olivera@yahoo.es
de Escalante-Yangüela
B
B
Velilla-Soriano
C
C
Amores-Arriaga
B
B
Martín-Fortea
P
P
Navarro-Aguilar
M E
ME
D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008687:Metformin / Q000009:adverse effects*
D007004:Hypoglycemic Agents; D008687:Metformin