title: Leptin levels in gingival crevicular fluid during orthodontic tooth movement.
abstract: OBJECTIVE
  To test if leptin can be detected in the gingival crevicular fluid (GCF) around moving teeth, and to determine whether any changes occur during orthodontic tooth movement.
  
  
  METHODS
  An upper canine requiring distal movement served as the test tooth; the contralateral canine was used as a control tooth. The control tooth was included in the orthodontic appliance, but was not subjected to the orthodontic force. GCF sampling from the distal sites of the test and control teeth was done at baseline, 1 hour, 24 hours, and 168 hours.
  
  
  RESULTS
  Leptin concentrations of the test teeth decreased in a time-dependent manner. When compared with the baseline measurement, the decrease was significant at 168 hours (P < .05).
  
  
  CONCLUSIONS
  The concentration of leptin in GCF is decreased by orthodontic tooth movement; the results of the present study also suggest that leptin may have been one of the mediators responsible for orthodontic tooth movement.
authors.affiliation: Department of Periodontology, Atatürk University, Erzurum, Turkey. aydilsiz@yahoo.com
authors.forename: Alparslan
authors.initials: A
authors.lastname: Dilsiz
authors.forename: Nihat
authors.initials: N
authors.lastname: Kiliç
authors.forename: Tugba
authors.initials: T
authors.lastname: Aydin
authors.forename: F Nesibe
authors.initials: FN
authors.lastname: Ates
authors.forename: Meltem
authors.initials: M
authors.lastname: Zihni
authors.forename: Caglar
authors.initials: C
authors.lastname: Bulut
mesh_terms: D000293:Adolescent; D003481:Cuspid / Q000473:pathology; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D005884:Gingival Hemorrhage / Q000145:classification; D006801:Humans; D020738:Leptin / Q000032:analysis*; D008297:Male; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification; D011446:Prospective Studies; D014087:Tooth Movement Techniques
chemical_list: D020738:Leptin