title: Potential of long-term dietary administration of rosemary in improving the antioxidant status of rat tissues following carbon tetrachloride intoxication.
abstract: In this study, 24 Wistar rats were allocated to 4 groups of 6 animals each. Groups 1 and 2 were fed a basal diet, while groups 3 and 4 were fed the basal diet supplemented further with ground rosemary at 1% level. Following 6-weeks feeding, groups 2 and 4 were injected 1 ml CCl(4)/kg bw and after six hours all animals were sacrificed. Results showed that feeding rosemary before CCl(4) treatment resulted in decline (P<0.05) of the increased aspartate transaminase, alanine transaminase and alkaline phosphatase activities and increase (P<0.05) of the reduced cholesterol and triacylglycerols in serum. It also decreased (P<0.05) lipid peroxidation and increased (P<0.05) the reduced hydroxyl anion radical and hydrogen peroxide scavenging activities in serum, liver, kidney and heart tissues. In addition, it increased (P<0.05) the reduced ABTS radical cation and the superoxide anion scavenging activities in all tissues except in heart and in kidney and heart tissues, respectively. These results suggest that dietary rosemary has the potential to become a promising functional food component.
authors.affiliation: Laboratory of Animal Nutrition, School of Veterinary Medicine, Aristotle University, 54 124 Thessaloniki, Greece. bots@vet.auth.gr
authors.forename: N
authors.initials: N
authors.lastname: Botsoglou
authors.forename: I
authors.initials: I
authors.lastname: Taitzoglou
authors.forename: I
authors.initials: I
authors.lastname: Zervos
authors.forename: E
authors.initials: E
authors.lastname: Botsoglou
authors.forename: M
authors.initials: M
authors.lastname: Tsantarliotou
authors.forename: P S
authors.initials: PS
authors.lastname: Chatzopoulou
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D052160:Benzothiazoles / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D002839:Chromans / Q000494:pharmacology; D004032:Diet; D004579:Electron Transport / Q000187:drug effects; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D029794:Ledum / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010636:Phenols / Q000032:analysis; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D013451:Sulfonic Acids / Q000378:metabolism
chemical_list: D000975:Antioxidants; D052160:Benzothiazoles; D002839:Chromans; D005609:Free Radicals; D010636:Phenols; D017382:Reactive Oxygen Species; D013451:Sulfonic Acids; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; D008315:Malondialdehyde; D009251:NADPH-Ferrihemoprotein Reductase; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid