Mycotic pulmonary artery aneurysm due to Aspergillus infection in a patient with leukemia: case report and review of the literature.
We present a case of a patient with hairy cell leukemia and pulmonary aspergillosis who developed a cycotic pulmonary artery aneurysm despite prolonged antifungal therapy. A review of the literature in regards to incidence, etiology, clinical manifestations and treatment options is included.
Sever
Matjaz
M
Verstovsek
Srdan
S
Erasmus
Jeremy
J
Mattiuzzi
Gloria N
GN
D000038:Abscess / Q000150:complications / Q000188:drug therapy; D000212:Acyclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D000666:Amphotericin B / Q000627:therapeutic use; D000785:Aneurysm, Infected / Q000209:etiology* / Q000601:surgery; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D001230:Aspergillus; D000077336:Caspofungin; D002442:Ceftazidime / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use; D054714:Echinocandins / Q000627:therapeutic use; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000150:complications* / Q000188:drug therapy; D055666:Lipopeptides; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000473:pathology; D015242:Ofloxacin / Q000627:therapeutic use; D011014:Pneumonia / Q000150:complications / Q000188:drug therapy; D011651:Pulmonary Artery / Q000473:pathology*; D055732:Pulmonary Aspergillosis / Q000150:complications* / Q000188:drug therapy; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives / Q000627:therapeutic use; D014640:Vancomycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D054714:Echinocandins; D055666:Lipopeptides; C068538:liposomal amphotericin B; D002981:Clindamycin; D014640:Vancomycin; D000666:Amphotericin B; D015725:Fluconazole; D002442:Ceftazidime; D015242:Ofloxacin; D000077336:Caspofungin; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir