title: [Absorption characteristics of ginsenoside Rb2 in Caco-2 cell monolayer].
abstract: OBJECTIVE
  To determine the concentration of ginsenoside Rb(2) and study the absorption characteristics of ginsenoside Rb(2) in Caco-2 cell monolayer.
  
  
  METHODS
  LC-MS-MS was used to determine the concentration of ginsenoside Rb(2), and the apparent permeability coefficient (P(app)) of ginsenoside Rb(2) was calculated.
  
  
  RESULTS
  P(app(AP-BL)) was 3.27 x 10(-7) cm.s(-1), P(app(BL-AP)) was 3.16 x 10(-6) cm.s(-1), and the efflux ratio (P(app(BL-AP))/P(app(AP-BL))) was 9.63.
  
  
  CONCLUSIONS
  The absorption characteristics of ginsenoside Rb(2) in Caco-2 cell model have been demonstrated.
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. zhaojie_0412@163.com
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.forename: Cai-hua
authors.initials: CH
authors.lastname: Yang
authors.forename: Ming
authors.initials: M
authors.lastname: Hu
authors.forename: Zhong-qiu
authors.initials: ZQ
authors.lastname: Liu
mesh_terms: D018938:Caco-2 Cells; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D036145:Ginsenosides / Q000493:pharmacokinetics*; D006801:Humans; D007408:Intestinal Absorption
chemical_list: D036145:Ginsenosides; C048026:ginsenoside Rb2