title: Complete free flap loss due to extensive hemodilution.
abstract: BACKGROUND
  Free tissue transfer in reconstruction of lower extremity wounds is well established. Controversy surrounds type and regimen of intravenous fluid application during microsurgery. Hemodilution is supposed to influence haemostatic process.
  
  
  METHODS
  We performed an analysis of 48 patients treated with a free latissimus dorsi muscle flap to the lower leg for posttraumatic soft-tissue coverage. Postoperative latissimus dorsi muscle flap perfusion was controlled by clinical monitoring. Intraoperative infusion management was evaluated retrospectively.
  
  
  RESULTS
  In 4 of 48 included patients, a complete loss of free latissimus dorsi muscle flap was registered. Concomitant increased saline infusion was detected (4,534 ml versus. 6,125 ml; P = 0.048). Similar findings for relation of total infusion volume to body weight were seen (44 ml/kg versus 69 ml/kg; P = 0.01). No significant colloid infusion was detected.
  
  
  CONCLUSIONS
  We demonstrate the clinical relevance of extensive intraoperative hyperhydration, which can provoke a complete free flap loss.
authors.affiliation: Department of Plastic and Hand Surgery, Burn Unit, University Hospital Schleswig-Holstein Campus Lübeck, Lübeck 23538, Germany. thomas.namdar@uk-sh.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Namdar
authors.forename: Tanja
authors.initials: T
authors.lastname: Bartscher
authors.forename: Peter L
authors.initials: PL
authors.lastname: Stollwerck
authors.forename: Peter
authors.initials: P
authors.lastname: Mailänder
authors.forename: Thomas
authors.initials: T
authors.lastname: Lange
mesh_terms: D000328:Adult; D005260:Female; D005440:Fluid Therapy / Q000009:adverse effects*; D006438:Hemodilution / Q000009:adverse effects*; D006801:Humans; D035002:Lower Extremity / Q000601:surgery*; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D012189:Retrospective Studies; D013524:Surgical Flaps / Q000098:blood supply*; D014022:Tissue Survival; D014947:Wounds and Injuries / Q000601:surgery*; D055815:Young Adult