[Preparation and drug release property of paclitaxel nanoparticles].
OBJECTIVE
To prepare paclitaxel nanoparticles and evaluate its drug release property in vitro.


METHODS
The chitosan-poly (lactide) copolymers were synthesized by ring-opening polymerization. Paclitaxel nanoparticles were prepared by the nanoprecipitation method. The encapsulation efficiency of the nanoparticles and the in vitro release of paclitaxel were studied.


RESULTS
The nanoparticles were fine and uniform spheres. The encapsulation efficiency of nanoparticles was up to 93.2%. The in vitro release profile showed the slow and stable release rate of paclitaxel.


CONCLUSIONS
This method is simple and the nanoparticles possess good physical performance as sustained release character in vitro.
Wang
Tie-wei
TW
National Center for Nanoscience and Technology, Beijing 100190, China. tieweiwang123@126.com
Wu
Yan
Y
Li
Ming-jun
MJ
Gao
Hong-xia
HX
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D048271:Chitosan / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D019344:Lactic Acid / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D010316:Particle Size; D011091:Polyesters; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D048271:Chitosan; D017239:Paclitaxel