title: Multi-scale heat and mass transfer modelling of cell and tissue cryopreservation.
abstract: Cells and tissues undergo complex physical processes during cryopreservation. Understanding the underlying physical phenomena is critical to improve current cryopreservation methods and to develop new techniques. Here, we describe multi-scale approaches for modelling cell and tissue cryopreservation including heat transfer at macroscale level, crystallization, cell volume change and mass transport across cell membranes at microscale level. These multi-scale approaches allow us to study cell and tissue cryopreservation.
authors.affiliation: Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.forename: Sangjun
authors.initials: S
authors.lastname: Moon
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Shao
authors.forename: Young Seok
authors.initials: YS
authors.lastname: Song
authors.forename: Utkan
authors.initials: U
authors.lastname: Demirci
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000502:physiology*; D002468:Cell Physiological Phenomena; D003198:Computer Simulation; D015925:Cryopreservation; D004735:Energy Transfer / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D013696:Temperature; D013814:Thermal Conductivity