The role of environmental light in sleep and health: effects of ocular aging and cataract surgery.
Environmental illumination profoundly influences human health and well-being. Recently discovered photoreceptive retinal ganglion cells (pRGCs) are primary mediators of numerous circadian, neuroendocrine and neurobehavioral responses. pRGCs provide lighting information to diverse nonvisual (non-image-forming) brain centers including the suprachiasmatic nuclei (SCN) which serve as the body's master biological clock. The SCN exert functional control over circadian aspects of physiology. The timing and strength (amplitude) of SCN rhythmic signals are affected by light exposure. Light deficiency may attenuate SCN function and its control of physiological and hormonal rhythms which in turn can result in a cascade of adverse events. Inadequate pRGC photoreception cannot be perceived consciously, but may aggravate many common age-associated problems including insomnia, depression and impaired cognition. In this review we (1) summarize circadian physiology, emphasizing light's critical role as the most important geophysical timing cue in humans; (2) analyze evidence that typical residential lighting is insufficient for optimal pRGC requirements in youth and even more so with advancing age; (3) show how ocular aging and cataract surgery impact circadian photoreception; and (4) review some of the diverse morbidities associated with chronodisruption in general and those which may be caused by light deficiency in particular.
Turner
Patricia L
PL
Department of Ophthalmology, University of Kansas School of Medicine, 7400 State Line Road, Prairie Village, KS 66208-3444, USA. plturnermd@att.net
Van Someren
Eus J W
EJ
Mainster
Martin A
MA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology; D002387:Cataract Extraction; D002648:Child; D002940:Circadian Rhythm / Q000502:physiology; D003072:Cognition Disorders / Q000503:physiopathology; D003863:Depression / Q000503:physiopathology; D005128:Eye Diseases / Q000503:physiopathology; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008027:Light; D008029:Lighting; D008297:Male; D008550:Melatonin / Q000502:physiology; D008875:Middle Aged; D020419:Photoreceptor Cells, Vertebrate / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000502:physiology; D012893:Sleep Wake Disorders / Q000503:physiopathology*; D013493:Suprachiasmatic Nucleus / Q000503:physiopathology; D055815:Young Adult
D008550:Melatonin