The sound of silence: human beta-defensin-1 gene untranslated SNPs change the predicted mRNA secondary structure in a length-dependent manner.
This study investigated how 5'-UTR of DEFB1 gene (encoding for the human beta-defensin-1) affects mRNA secondary structure and its correlation with translation efficiency in the susceptibility of diseases. It was possible to determine DEFB1 mRNA folding under the influence of 5'-UTR SNPs haplotypes and putative alternative transcript lengths. Different DEFB1 mRNAs that fold in a pattern that is haplotype and length-dependent are potentially able to drive changes in peptide expression dynamics.
Naslavsky
M S
MS
Crovella
S
S
Lima Filho
J L
JL
Rocha
C R C
CR
D020121:5' Untranslated Regions / Q000235:genetics*; D017398:Alternative Splicing / Q000276:immunology; D003198:Computer Simulation; D005786:Gene Expression Regulation / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D007113:Immunity, Innate; D009690:Nucleic Acid Conformation; D020641:Polymorphism, Single Nucleotide; D011485:Protein Binding / Q000235:genetics; D014176:Protein Biosynthesis / Q000235:genetics / Q000276:immunology; D012333:RNA, Messenger / Q000235:genetics*; D012984:Software; D014157:Transcription Factors / Q000378:metabolism; D023083:beta-Defensins / Q000235:genetics / Q000378:metabolism*
D020121:5' Untranslated Regions; C406407:DEFB1 protein, human; D012333:RNA, Messenger; D014157:Transcription Factors; D023083:beta-Defensins