[Cardiotoxicity induced by 5-fluorouracil or capecitabine].
5-fluorouracil and capecitabine have significant antineoplastic activity towards various solid tumors. Cardiotoxicity causing angina, arrhythmia and infarction are serious adverse events associated with these agents. The pathogenesis is discussed and symptoms of cardiotoxicity, intervention with nitroglycerine and risk factors as cardiac comorbidity are described. Following cardiotoxicity, lack of alternative active agents may provide grounds to rechallenge with 5-FU. In this situation, dose-modified 5-FU-based chemotherapy supported by medical antiangina prevention is feasible.
Jensen
Søren Astrup
SA
Onkologisk Afdeling 5073, Rigshospitalet, DK-2100 København Ø, Denmark. soren.a.jensen@mail.tele.dk
Baeksgaard
Lene
L
Petersen
Lone Nørgaard
LN
Reiter
Lars
L
Sørensen
Jens Benn
JB
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D000069287:Capecitabine; D015179:Colorectal Neoplasms / Q000188:drug therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives; D005996:Nitroglycerin / Q000008:administration & dosage; D011355:Prodrugs; D012307:Risk Factors; D014665:Vasodilator Agents / Q000008:administration & dosage
D000964:Antimetabolites, Antineoplastic; D011355:Prodrugs; D014665:Vasodilator Agents; D003841:Deoxycytidine; D000069287:Capecitabine; D005996:Nitroglycerin; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate; D005472:Fluorouracil