Clonal dissemination of Klebsiella pneumoniae carbapenemase KPC-3 in Long Beach, California.
Carbapenems (CARBs) are the primary treatment for infections caused by extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae strains. Production of a serine carbapenemase, KPC, is increasing alarmingly in the United States and is probably contributing to CARB resistance rates. We describe the clinical and molecular characteristics of four infections caused by KPC-3 K. pneumoniae strains.
Le
Jennifer
J
University of California, San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, 9500 Gilman Drive, MC 0714, La Jolla, CA 92093-0714, USA. jenle@ucsd.edu.
Castanheira
Mariana
M
Burgess
David S
DS
McKee
Barbara
B
Iqbal
Raza
R
Jones
Ronald N
RN
D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics; D002140:California; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology* / Q000473:pathology*; D007711:Klebsiella pneumoniae / Q000145:classification* / Q000201:enzymology* / Q000302:isolation & purification; D007902:Length of Stay; D008875:Middle Aged; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001618:beta-Lactamases; C495220:beta-lactamase KPC-3, Klebsiella pneumoniae