title: Immunohistochemical analyses of E-cadherin, beta-catenin, CD44s, and CD44v6 expressions, and Ki-67 labeling index in intraductal papillary mucinous neoplasms of the pancreas and associated invasive carcinomas.
abstract: We examined the expressions of adhesion molecules (E-cadherin, beta-catenin, CD44s, and CD44v6) and Ki-67 labeling index (Ki-67 LI) in low- and moderate-grade dysplasia and invasive carcinoma components in ten noninvasive intraductal papillary mucinous neoplasms (IPMNs) of the pancreas and eight invasive carcinomas associated with IPMNs of the pancreas using immunohistochemical methods. There was no significant difference in regard to the proportion of components expressing either E-cadherin or beta-catenin in more than 70% of the tumor cells between the low- and moderate-grade dysplasia components. In contrast, the proportion of those in invasive carcinoma components was significantly lower than in low- or moderate-grade dysplasia components. Also, there was no significant difference in the proportion of components expressing CD44s or CD44v6 in more than 5% of tumor cells among low-grade dysplasia, moderate-grade dysplasia, and invasive carcinoma components. In contrast, the Ki-67 LI values increased in the order of low-grade dysplasia, moderate-grade dysplasia, and invasive carcinoma components, with significant differences among them. The present results indicate that carcinoma components are associated with a decrease in tumor cells expressing E-cadherin and beta-catenin and have the highest proliferative activity.
authors.affiliation: Department of Pathology, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Okimura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirano
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishigami
authors.forename: Shigemitsu
authors.initials: S
authors.lastname: Ueyama
authors.forename: Shiro
authors.initials: S
authors.lastname: Tachibana
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Koji
authors.initials: K
authors.lastname: Yamanegi
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohyama
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Terada
authors.forename: Keiji
authors.initials: K
authors.lastname: Nakasho
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000378:metabolism*; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D007150:Immunohistochemistry / Q000379:methods; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology; D051176:beta Catenin / Q000378:metabolism*
chemical_list: C112697:CD44v6 antigen; D015820:Cadherins; D015815:Cell Adhesion Molecules; D018960:Hyaluronan Receptors; D019394:Ki-67 Antigen; D051176:beta Catenin