title: Gastroduodenitis and Helicobacter pylori in Nigerians: histopathological assessment of endoscopic biopsies.
abstract: OBJECTIVE
  Morphologic changes seen in the endoscopic biopsies are dynamic and could be predictive of more important sequelae of chronic H. pylori gastritis such as gastric carcinoma and lymphoma. The objective of the study was to review the biopsy appearances of endoscopic gastroduodenal biopsies using the updated Sydney System of classification in order to throw some light on the biology of gastroduodenitis.
  
  
  METHODS
  A retrospective review of all endoscopic gastroduodenal biopsies received in the department of Morbid Anatomy of Obafemi Awolowo University Teaching Hospitals Complex between 1994 and 2003 was undertaken. Grading of the chronicity, activity, atrophy, H. pylori density and metaplasia were done using the updated Sydney System of classification and grading.
  
  
  RESULTS
  A total of 1047 gastric and 47 duodenal biopsies from 1047 patients were reviewed. There was evidence of significant chronic gastritis in 98.1% of the gastric biopsies and in 78.0% of these, H. pylori was the main identifiable aetiological agent. Marked atrophic changes and intestinal metaplasia that are known to predispose to gastric malignances were seen in 4.9% and 9.3% of our cases respectively. Chronic duodenitis was seen in 83% of the duodenal biopsies and in 29.6%, H. pylori was seen on a background of gastric metaplasia.
  
  
  CONCLUSIONS
  The prevalence of H. pylori was high and it was the single most important aetiological factor responsible for the biopsy changes associated with chronic gastroduodenitis.
authors.affiliation: Department of Morbid Anatomy and Forensic Medicine,Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State.
authors.forename: K B
authors.initials: KB
authors.lastname: Badmos
authors.forename: O S
authors.initials: OS
authors.lastname: Ojo
authors.forename: O S
authors.initials: OS
authors.lastname: Olasode
authors.forename: A O
authors.initials: AO
authors.lastname: Arigbabu
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004382:Duodenitis / Q000382:microbiology / Q000473:pathology*; D004724:Endoscopy; D005260:Female; D005756:Gastritis / Q000382:microbiology / Q000473:pathology*; D016481:Helicobacter Infections / Q000150:complications / Q000473:pathology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult