title: [A case of advanced rectal cancer with severe liver dysfunction due to multiple liver metastases].
abstract: We report a case of rectal cancer with unresectable multiple liver metastases, which was worried about the transition from liver dysfunction to liver failure. The male patient in his 70s was diagnosed as advanced rectal cancer with severe liver dysfunction because of multiple liver metastases. Hepatic arterial infusion (HAI) chemotherapy, which was effective to reduce the size of metastatic liver tumors, was initially started. During HAI chemotherapy, sigmoid colostomy was performed. He recovered from liver dysfunction after he had been treated with 13th cycle HAI chemotherapy. He was treated with the modified FOLFOX6 regimen following a resection of rectal cancer. Although the standard therapy for colorectal cancer with unresectable liver metastases is firstly systemic chemotherapy such as FOLFOX or FOLFIRI, it might be better to control the liver metastases by HAI chemotherapy when a liver function is severely damaged by extensive liver tumors.
authors.affiliation: Department of Surgical Oncology, Tokyo Medical and Dental University Graduate School.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Higuchi
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Tsukamoto
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Fujimori
authors.forename: Goshi
authors.initials: G
authors.lastname: Oda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Okazaki
authors.forename: Megumi
authors.initials: M
authors.lastname: Ishiguro
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Satoru
authors.initials: S
authors.lastname: Iida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Uetake
authors.forename: Masamichi
authors.initials: M
authors.lastname: Yasuno
authors.forename: Masayuki
authors.initials: M
authors.lastname: Enomoto
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sugihara
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D002955:Leucovorin / Q000008:administration & dosage; D008107:Liver Diseases / Q000209:etiology*; D008113:Liver Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil