EBV-associated polymorphic posttransplant lymphoproliferative disorder presenting as gingival ulcers.
Posttransplant lymphoproliferative disorders (PTLDs) present a wide clinicopathological spectrum, varying from the usual Epstein-Barr virus (EBV)-driven infectious mononucleosis-type polyclonal proliferations to EBV-positive or EBV-negative proliferations indistinguishable from overt lymphomas that occur in immunocompetent individuals. PTLDs characteristically have a predilection for extranodal sites and association with EBV.These disorders are usually B-cell type, although T-cell and rare cases involving both T- and B-cell types have also been described. The initial treatment consists in decreasing the immnosupressive therapy, usually with favorable results. The authors report on a rare case of a 19-year-old girl, with post-renal transplantation EBV-associated polymorphic lymphoproliferative gingival ulcerated lesions. To the best of their knowledge, this is the first case described in the English-language literature of polymorphic PTLD involving both B-cell and T-cell lineages, with an unusual immunoprofile affecting the mouth. The authors warn that this condition could be easily misdiagnosed as malignant lymphoma if not properly recognized.
León
Jorge Esquiche
JE
Departmento de Diagnóstico Oral, Faculdade de Odontologia, Piracicaba Dental School, University of Campinas-UNICAMP, Piracicaba-SP, Brazil. jorgeesquiche@yahoo.com.br
Takahama Júnior
Ademar
A
Vassallo
José
J
Soares
Fernando Augusto
FA
de Almeida
Oslei Paes
OP
Lopes
Márcio Ajudarte
MA
D001402:B-Lymphocytes; D020031:Epstein-Barr Virus Infections; D004854:Herpesvirus 4, Human; D006801:Humans; D008232:Lymphoproliferative Disorders; D014456:Ulcer