title: Hedgehog signalling in colon cancer and stem cells.
abstract: The participation of the HH pathway in colon cancer has remained controversial. In this issue, Varnat et al (2009) demonstrate that HH signalling is essential for human colon cancer growth, recurrence, metastases and stem cell expansion. This closeup by Gulino et al discusses the paper and its implications.
authors.affiliation: Department of Experimental Medicine, Sapienza University, Rome, Italy. alberto.gulino@uniroma1.it
authors.forename: Alberto
authors.initials: A
authors.lastname: Gulino
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Ferretti
authors.forename: Enrico
authors.initials: E
authors.lastname: De Smaele
mesh_terms: D003110:Colonic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000166:cytology* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D000071676:Zinc Finger Protein GLI1
chemical_list: C400551:GLI1 protein, human; D053823:Hedgehog Proteins; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1