Comparison of cyanoacrylate-assisted arteriotomy closure with conventional closure technique.
BACKGROUND
We aimed to compare conventional suture closure of arteriotomy with N-butyl-cyanoacrylate-assisted suture closure.


METHODS
Forty Wistar rats were randomly divided into two groups. Standard arteriotomy was performed to the abdominal aorta through a midline incision. In the first group, arteriotomy was closed by 3 stitches with 45 degrees between each and in the second by two stitches with 0.1 ml (12-12.5 mg) cyanoacrylate. Amount of blood loss, operation time and severity of myointimal hyperplasia by immunohistochemistry on aorta segments were measured on postoperative days 7 and 30.


RESULTS
Mean anastomotic time was 13.5 +/- 1.64 in the first and 13.0 +/- 1.75 min in the second group (p = 0.356). Operation time was 23.45 +/- 3.63 in the control and 21.0 +/- 3.09 min in the second group (p = 0.027). Mean amount of bleeding was 473.75 +/- 260.5 in the first and 327.5 +/- 155.36 microl in the second group (p = 0.037). Intimal thickness on the 7th day was 80.62 +/- 7.92 in the first and 83.24 +/- 3.42 microm in the second group, and on the 30th day was 81.64 +/- 5.11 in the first and 88.77 +/- 11.03 microm in the second group. The early and late intimal thicknesses were similar (p = 0.35 and 0.87, respectively).


CONCLUSIONS
Reconstruction of arteriotomies with fewer sutures in combination with cyanoacrylate is a safe method associated with less blood loss and shorter operation time. It also does not lead to increased myointimal hyperplasia.
Ersoy
Omer Faik
OF
Department of General Surgery, Gaziosmanpaşa University ,Faculty of Medicine, Tokat, Turkey. dromerfersoy@yahoo.com
Kayaoğlu
Hüseyin Ayhan
HA
Celik
Alper
A
Ozkan
Namik
N
Lortlar
Neşe
N
Omeroğlu
Suna
S
D000714:Anastomosis, Surgical; D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery*; D003487:Cyanoacrylates / Q000627:therapeutic use*; D006470:Hemorrhage / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D013536:Suture Techniques; D017539:Tunica Intima / Q000187:drug effects / Q000601:surgery
D003487:Cyanoacrylates