Absence of weight gain association with the HTR2C -759C/T polymorphism in patients with schizophrenia treated with iloperidone.
Weight gain is a common side effect of antipsychotics, contributing to poor treatment adherence, and previously linked to the -759C/T polymorphism near the serotonin receptor 2C gene. The effect of this polymorphism was analyzed in schizophrenia patients treated with iloperidone for up to 7 months. No association was detected with the modest weight changes observed in these patients.
Thompson
Andrew
A
Vanda Pharmaceuticals Inc., Rockville, MD, USA.
Lavedan
Christian
C
Volpi
Simona
S
D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007555:Isoxazoles / Q000627:therapeutic use*; D008297:Male; D010879:Piperazines / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use*; D011110:Polymorphism, Genetic / Q000235:genetics*; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D013844:Thiazoles / Q000627:therapeutic use; D015430:Weight Gain / Q000187:drug effects / Q000235:genetics / Q000502:physiology
D014150:Antipsychotic Agents; D007555:Isoxazoles; D010879:Piperazines; D010880:Piperidines; D044405:Receptor, Serotonin, 5-HT2C; D013844:Thiazoles; C092292:ziprasidone; C081732:iloperidone