title: Glioblastoma multiforme in the posterior cranial fossa in a patient with neurofibromatosis type I.
abstract: Patients with Neurofibromatosis type 1 (NF1) have an increased risk of developing neoplasms. The most common brain tumors, found in 15%-20% of NF1 patients, are hypothalamic-optic gliomas, followed by brainstem and cerebellar pilocytic astrocytomas. These tumors generally have a benign nature. NF1 patients are predisposed to a 5-fold increased incidence of high-grade astrocytomas, which are usually located in supratentorial regions of the brain. We present an NF1 patient who developed a high-grade astrocytoma in the posterior fossa and discuss possible pathophysiological mechanisms.
authors.affiliation: Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands.
authors.forename: Marike L D
authors.initials: ML
authors.lastname: Broekman
authors.forename: Roelof
authors.initials: R
authors.lastname: Risselada
authors.forename: Jooyeon
authors.initials: J
authors.lastname: Engelen-Lee
authors.forename: Wim G M
authors.initials: WG
authors.lastname: Spliet
authors.forename: Bon H
authors.initials: BH
authors.lastname: Verweij