[Efficacy of tosufloxacin in genital chlamydial infections].
According to the 2006 and 2008 "Guidelines for diagnosis and treatment of sexually transmitted diseases" by the Japanese Society for Sexually Transmitted Diseases, quinolones, macrolides and tetracyclines are recommended to treat chlamydial infections. The administration method based on pharmacokinetic/pharmacodynamic theory, as well as the selection of antimicrobial drugs, is important in antimicrobial therapy. It is currently assumed that the efficacy of administering high-dose quinolones once a day is greater than dividing the dose over multiple administrations. To verify the treatment effects of the recommended tosufloxacin dose of 150 mg b.i.d. (300 mg/day) for 7 days, we performed a comparative multicenter open label study of 150 mg b.i.d. and 300 mg q.d. (300 mg/day). The results indicated complete efficacy with 100% (150 mg b.i.d.: 49/49, 300 mg q.d.: 57/57) eradication of Chlamydia trachomatis at both dosages. The clinical efficacy was "markedly effective" in 57.1% (28/49) of cases, "effective" in 42.9% (21/49), and "not effective" in 0% (0/49) in the 150 mg b.i.d. group, while these values were 59.6% (34/57), 40.4% (23/57) and 0% (0/57), respectively, in the 300 mg q.d. group. Quinolone therapy for genital chlamydial infections with tosufloxacin doses of 150 mg b.i.d. was confirmed to be effective as recommended in the guidelines. Moreover, tosufloxacin at 300 mg q.d. was shown to be an effective therapy.
Mikamo
Hiroshige
H
Department of Infection Control Science, Graduate School of Medicine, Aichi Medical University School of Medicine.
Yamagishi
Yuka
Y
Tanaka
Kaori
K
Watanabe
Kunitomo
K
Fujiwara
Michihisa
M
Iwasaku
Kazuhiro
K
Izumi
Koji
K
Takahashi
Keiichi
K
Nakabe
Ken
K
Nozawa
Kenji
K
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002690:Chlamydia Infections / Q000188:drug therapy*; D002692:Chlamydia trachomatis; D004334:Drug Administration Schedule; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage*; D005831:Genital Diseases, Female / Q000188:drug therapy*; D006801:Humans; D009287:Naphthyridines / Q000008:administration & dosage*; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome; D055815:Young Adult
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C055185:tosufloxacin