Systems-level modeling the effects of arsenic exposure with sequential pulsed and fluctuating patterns for tilapia and freshwater clam.
The purpose of this paper was to use quantitative systems-level approach employing biotic ligand model based threshold damage model to examine physiological responses of tilapia and freshwater clam to sequential pulsed and fluctuating arsenic concentrations. We tested present model and triggering mechanisms by carrying out a series of modeling experiments where we used periodic pulses and sine-wave as featured exposures. Our results indicate that changes in the dominant frequencies and pulse timing can shift the safe rate distributions for tilapia, but not for that of freshwater clam. We found that tilapia increase bioenergetic costs to maintain the acclimation during pulsed and sine-wave exposures. Our ability to predict the consequences of physiological variation under time-varying exposure patterns has also implications for optimizing species growing, cultivation strategies, and risk assessment in realistic situations.
Chen
Wei-Yu
WY
Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei 10617, Taiwan, ROC.
Tsai
Jeng-Wei
JW
Ju
Yun-Ru
YR
Liao
Chung-Min
CM
D000818:Animals; D001151:Arsenic / Q000032:analysis / Q000633:toxicity*; D049872:Bivalvia / Q000502:physiology*; D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods*; D005618:Fresh Water / Q000032:analysis; D010829:Physiological Phenomena / Q000187:drug effects; D017210:Tilapia / Q000502:physiology*; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity*
D014874:Water Pollutants, Chemical; D001151:Arsenic