Design, synthesis and studies of triphosphate analogues for the production of anti AZT-TP antibodies.
Triphosphates anabolites are the active chemical species of nucleosidic reverse transcriptase inhibitors in HIV-therapy. Herein, we describe (i) the design of stable triphosphate analogues of AZT using molecular modelling, (ii) their synthesis and (iii) their use for producing anti AZT-TP antibodies in the aim of developing an immunoassay for therapeutic drug monitoring.
Roucairol
Camille
C
Laboratoire de Chimie des Molécules Bioactives et Arômes, UMR 6001 CNRS, Institut de Chimie de Nice, Université de Nice-Sophia Antipolis, Nice, France.
Azoulay
Stéphane
S
Nevers
Marie-Claire
MC
Golebiowski
Jérôme
J
Créminon
Christophe
C
Grassi
Jacques
J
Burger
Alain
A
Duval
Danièle
D
D000818:Animals; D000917:Antibody Formation; D054306:Dideoxynucleotides / Q000097:blood / Q000276:immunology*; D015195:Drug Design; D011122:Polyphosphates / Q000097:blood / Q000138:chemical synthesis* / Q000276:immunology*; D011817:Rabbits; D013942:Thymine Nucleotides / Q000097:blood / Q000276:immunology*; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000097:blood / Q000276:immunology
D054306:Dideoxynucleotides; D011122:Polyphosphates; D013942:Thymine Nucleotides; D015215:Zidovudine; C052873:zidovudine triphosphate; C005692:triphosphoric acid