title: Circulating procoagulant microparticles in acute pulmonary embolism: a case-control study.
abstract: We investigated whether circulating procoagulant microparticles (CPMPs) contributed to hypercoagulability in 45 patients with acute pulmonary embolism (APE) and in 45 controls with and 45 controls without cardiovascular risk factors. Concentrations of CPMPs and platelet-derived microparticles (PMPs) were statistically significantly higher in patients with APE than in controls without cardiovascular risk factors. PMPs appeared to be the main source of procoagulant microparticle release in APE, but this correlation disappeared when APE patients were compared to controls with cardiovascular risk factors. CPMPs may have a role in venous thrombosis as mediators of cardiovascular risk factors.
authors.affiliation: Cardiology Department, Saint-Antoine University and Medical School, France; Université Pierre et Marie Curie, Paris, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Bal
authors.affiliation: Cardiology Department, Saint-Antoine University and Medical School, France; Université Pierre et Marie Curie, Paris, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ederhy
authors.affiliation: Cardiology Department, Saint-Antoine University and Medical School, France; Université Pierre et Marie Curie, Paris, France.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Di Angelantonio
authors.affiliation: INSERM U.770, Hôpital de Bicêtre, Université Louis Pasteur, Faculté de Médecine, Institut d'Hématologie et Immunologie, Strasbourg, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Toti
authors.affiliation: INSERM U.770, Hôpital de Bicêtre, Université Louis Pasteur, Faculté de Médecine, Institut d'Hématologie et Immunologie, Strasbourg, France.
authors.forename: Fatiha
authors.initials: F
authors.lastname: Zobairi
authors.affiliation: Cardiology Department, Saint-Antoine University and Medical School, France; Université Pierre et Marie Curie, Paris, France.
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Dufaitre
authors.affiliation: Cardiology Department, Saint-Antoine University and Medical School, France; Université Pierre et Marie Curie, Paris, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Meuleman
authors.affiliation: INSERM U970 Paris Cardiovascular Research Center PARCC, Paris, France and Université Paris Descartes UMR-S970, Paris, France.
authors.forename: Ziad
authors.initials: Z
authors.lastname: Mallat
authors.affiliation: Cardiology Department, Saint-Antoine University and Medical School, France; Université Pierre et Marie Curie, Paris, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Boccara
authors.affiliation: INSERM U970 Paris Cardiovascular Research Center PARCC, Paris, France and Université Paris Descartes UMR-S970, Paris, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Tedgui
authors.affiliation: INSERM U.770, Hôpital de Bicêtre, Université Louis Pasteur, Faculté de Médecine, Institut d'Hématologie et Immunologie, Strasbourg, France.
authors.forename: Jean Marie
authors.initials: JM
authors.lastname: Freyssinet
authors.affiliation: Cardiology Department, Saint-Antoine University and Medical School, France; Université Pierre et Marie Curie, Paris, France. Electronic address: ariel.cohen@sat.aphp.fr.
authors.forename: Ariel
authors.initials: A
authors.lastname: Cohen
mesh_terms: D000208:Acute Disease; D001777:Blood Coagulation / Q000502:physiology; D016022:Case-Control Studies; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D006801:Humans; D011655:Pulmonary Embolism / Q000097:blood* / Q000175:diagnosis; D012307:Risk Factors