title: Properties of the intracellular transient receptor potential (TRP) channel in yeast, Yvc1.
abstract: Transient receptor potential (TRP) channels are found among mammals, flies, worms, ciliates, Chlamydomonas, and yeast but are absent in plants. These channels are believed to be tetramers of proteins containing six transmembrane domains (TMs). Their primary structures are diverse with sequence similarities only in some short amino acid sequence motifs mainly within sequences covering TM5, TM6, and adjacent domains. In the yeast genome, there is one gene encoding a TRP-like sequence. This protein forms an ion channel in the vacuolar membrane and is therefore called Yvc1 for yeast vacuolar conductance 1. In the following we summarize its prominent features.
authors.affiliation: Experimentelle und Klinische Pharmakologie und Toxikologie, Medizinische Fakultät, Universität des Saarlandes, 66421 Homburg, Germany. chang.yiming@uks.eu
authors.forename: Yiming
authors.initials: Y
authors.lastname: Chang
authors.forename: Gabriel
authors.initials: G
authors.lastname: Schlenstedt
authors.forename: Veit
authors.initials: V
authors.lastname: Flockerzi
authors.forename: Andreas
authors.initials: A
authors.lastname: Beck
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000737:chemistry* / Q000378:metabolism*; D004553:Electric Conductivity; D042541:Intracellular Space / Q000378:metabolism*; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry* / Q000378:metabolism*; D050052:TRPC Cation Channels; D050051:Transient Receptor Potential Channels / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D029701:Saccharomyces cerevisiae Proteins; D050052:TRPC Cation Channels; D050051:Transient Receptor Potential Channels; C446509:Yvc1 protein, S cerevisiae