title: Cytotoxic triterpenoid saponins from the stem bark of Antonia ovata.
abstract: Phytochemical investigation of the MeOH extract of the stem bark of Antonia ovata led to the isolation of four triterpenoid saponins, along with eleven known compounds. Their structures were established by extensive 1D and 2D NMR, as well as HR-MS analysis and acid hydrolysis. All isolated saponins contained the same tetrasaccharide chain O-beta-d-xylopyranosyl-(1-->2)-O-beta-d-glucopyranosyl-(1-->3)-O-[beta-d-glucopyranosyl-(1-->2)]-beta-d-glucuropyranoside linked to C-3 of esterified derivatives of R(1)-barrigenol, A(1)-barrigenol, barringtogenol C, or camelliagenin. Biological evaluation of the compounds against KB cell line revealed a potent cytotoxic activity with IC(50) values ranging from 3.1 to 6.6microM. The known compounds were found to be inactive at 10microg/ml concentration.
authors.affiliation: Laboratoire de Pharmacognosie, Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, IFR 53 Biomolécules, Bâtiment 18, BP 1039, 51687 Reims Cedex 2, France. abdulmagid.alabdulmagid@univ-reims.fr
authors.forename: Abdulmagid Alabdul
authors.initials: AA
authors.lastname: Magid
authors.forename: Hélène
authors.initials: H
authors.lastname: Bobichon
authors.forename: Nicolas
authors.initials: N
authors.lastname: Borie
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lalun
authors.forename: Christophe
authors.initials: C
authors.lastname: Long
authors.forename: Christian
authors.initials: C
authors.lastname: Moretti
authors.forename: Catherine
authors.initials: C
authors.lastname: Lavaud
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D002726:Chlorogenic Acid / Q000031:analogs & derivatives; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D039823:Iridoids / Q000737:chemistry; D007624:KB Cells; D029541:Loganiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D024301:Plant Bark / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D003603:Cytotoxins; D039823:Iridoids; D012503:Saponins; D014315:Triterpenes; D002726:Chlorogenic Acid