title: Design, synthesis and biological evaluation of simplified analogues of the RNA polymerase inhibitor etnangien.
abstract: Novel simplified analogues of the potent RNA polymerase inhibitor etnangien were obtained by total synthesis and evaluated for antibacterial activity against Gram-positive bacteria and one Gram-negative bacterium.
authors.affiliation: Institut für Organische Chemie, Ruprecht-Karls-Universität Heidelberg, INF 270, D-69120 Heidelberg, Germany. dirk.menche@oci.uni-heidelberg.de
authors.forename: Dirk
authors.initials: D
authors.lastname: Menche
authors.forename: Pengfei
authors.initials: P
authors.lastname: Li
authors.forename: Herbert
authors.initials: H
authors.lastname: Irschik
mesh_terms: D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development; D018942:Macrolides / Q000138:chemical synthesis* / Q000494:pharmacology*; D011090:Polyenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development
chemical_list: D018942:Macrolides; D011090:Polyenes; C521655:etnangien; D012321:DNA-Directed RNA Polymerases