title: Tityus fasciolatus envenomation induced cardio-respiratory alterations in rats.
abstract: The present study characterized envenomation in young rats by Tityus fasciolatus, an endemic scorpion to Central Brazilian and state of Minas Gerais. Electrocardiographic examinations were performed prior to treatment and every 5 min during the first 30 min after envenomation. The cardiac blood profile [creatine kinase, CK isoenzyme MB, lactate dehydrogenase, aspartate aminotransferase and troponina] together with macroscopic and microscopic alterations in the lungs and heart were evaluated. Envenomated animals showed ECG changes suggesting electrolytic imbalance, myocarditis and venom interference on the conduction tissue. Biochemical analyses indicated myocardial damage with high levels of CK, CK-MB and LDH. Macroscopic and microscopic findings included detection of pulmonary haemorrhages. In conclusion, T. fasciolatus venom leads to acute cardio-respiratory changes in young rats.
authors.affiliation: Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: M C L
authors.initials: MC
authors.lastname: Pinto
authors.forename: L R
authors.initials: LR
authors.lastname: Borboleta
authors.forename: M B
authors.initials: MB
authors.lastname: Melo
authors.forename: C R
authors.initials: CR
authors.lastname: Labarrére
authors.forename: M M
authors.initials: MM
authors.lastname: Melo
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006331:Heart Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D006470:Hemorrhage / Q000139:chemically induced / Q000503:physiopathology; D008171:Lung Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009205:Myocarditis / Q000139:chemically induced / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D065008:Scorpion Stings / Q000150:complications / Q000209:etiology* / Q000503:physiopathology; D012604:Scorpion Venoms / Q000506:poisoning*; D012605:Scorpions / Q000502:physiology*
chemical_list: D012604:Scorpion Venoms