title: Comparative study of the ocular irritation potential of various alkyl polyglucoside surfactants.
abstract: In the present work, we assessed the relationship between alkyl carbon chain length and ocular irritation potentials using the hen's egg test-chorioallantoic membrane (HET-CAM) and bovine corneal opacity and permeability (BCOP) assays using 5 commercial alkyl polyglucoside surfactants with different compositions of alkyl chain lengths (C(6)-C(16)). With HET-CAM, there was a good correlation between the proportion of C(10) alkyl polyglucoside and the eye irritation potential Q score (r(2) = 0.912, p = .011). There were no significant differences between the proportion of C(10) alkyl polyglucoside and corneal opacity in BCOP assays; however, there was a relatively high positive correlation between the proportion of C(10) alkyl carbon chain lengths and corneal permeability (r(2) = 0.736, p = .063).
authors.affiliation: Skin Research Institute, AmorePacific R&D Center, Yongin-si, Korea.
authors.forename: Sun-A
authors.initials: SA
authors.lastname: Cho
authors.forename: Ju-Hee
authors.initials: JH
authors.lastname: Han
authors.forename: Susun
authors.initials: S
authors.lastname: An
authors.forename: Key Hyun
authors.initials: KH
authors.lastname: Lee
authors.forename: Jae-Hak
authors.initials: JH
authors.lastname: Park
authors.forename: Han Kon
authors.initials: HK
authors.lastname: Kim
authors.forename: Tae Ryong
authors.initials: TR
authors.lastname: Lee
mesh_terms: D000818:Animals; D002417:Cattle; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000187:drug effects*; D003315:Cornea / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003318:Corneal Opacity / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D005960:Glucosides / Q000737:chemistry / Q000633:toxicity*; D015394:Molecular Structure; D010539:Permeability; D018570:Risk Assessment; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000737:chemistry / Q000633:toxicity*
chemical_list: D005960:Glucosides; D013501:Surface-Active Agents