title: A case of solitary fibrous tumor of the kidney: an immunohistochemical and ultrastructural study with a review of the literature.
abstract: A solitary fibrous tumor (SFT) is an unusual spindle cell neoplasm that usually arises in the pleura but rarely occurs in the kidney. Despite its rarity, histological diagnosis of SFT is crucial to avoid misdiagnosis with other malignant tumors in the kidney. We report a SFT of the left kidney that presented as a malignant tumor on radiographic findings in a 75-year-old Japanese woman. The tumor was well circumscribed and composed of a mixture of spindle cells and dense collagenous bands with no areas of necrosis or cystic changes noted macroscopically or microscopically. Electron microscopy showed fibroblast-like cells with well-developed rough endoplasmic reticulum, surrounded with collagen fibers. Immunohistochemistry revealed reactivity for vimentin, CD34, Bcl-2, and CD99, but no staining for cytokeratin, S-100, desmin, actin, D2-40, or epithelial membrane antigen (EMA). These findings were compatible with those of SFT. Although SFT of the kidney is extremely rare, this tumor must be included in the differential diagnosis when we encounter renal tumors consisting of mesenchymal elements. Immunohistochemical study is the key to diagnosis for SFT, and ultrastructural study is useful for its diagnosis.
authors.affiliation: Department of Urology, Nerima Hikarigaoka Hospital, Nihon University School of Medicine, 2-11-1 Hikarigaoka, Nerima-ku, Tokyo 179-0072, Japan. byd04561@nifty.com
authors.forename: Daisaku
authors.initials: D
authors.lastname: Hirano
authors.forename: Aya
authors.initials: A
authors.lastname: Mashiko
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Murata
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Satoh
authors.forename: Taketo
authors.initials: T
authors.lastname: Ichinose
authors.forename: Satoru
authors.initials: S
authors.lastname: Takahashi
authors.forename: Toyoharu
authors.initials: T
authors.lastname: Jike
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sugitani
mesh_terms: D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology / Q000648:ultrastructure; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000473:pathology; D008279:Magnetic Resonance Imaging; D054364:Solitary Fibrous Tumors / Q000175:diagnosis / Q000473:pathology
chemical_list: D018952:Antigens, CD34