title: Influence of partial sleep deprivation on energy balance and insulin sensitivity in healthy women.
abstract: BACKGROUND
  Voluntary sleep restriction is a lifestyle feature of modern societies that may contribute to obesity and diabetes. The aim of the study was to investigate the impact of partial sleep deprivation on the regulation of energy balance and insulin sensitivity.
  
  
  METHODS
  In a controlled intervention, 14 healthy women (age 23-38 years, BMI 20.0-36.6 kg/m(2)) were investigated after 2 nights of >8 h sleep/night (T0), after 4 nights of consecutively increasing sleep curtailment (7 h sleep/night, 6 h sleep/night, 6 h sleep/night and 4 h sleep/night; T1) and after 2 nights of sleep recovery (>8 h sleep/night; T2). Resting and total energy expenditure (REE, TEE), glucose-induced thermogenesis (GIT), physical activity, energy intake, glucose tolerance and endocrine parameters were assessed.
  
  
  RESULTS
  After a decrease in sleep du-ration, energy intake (+20%), body weight (+0.4 kg), leptin/fat mass (+29%), free triiodothyronine (+19%), free thyroxine (+10%) and GIT (+34%) significantly increased (all p < 0.05). Mean REE, physical activity, TEE, oral glucose tolerance, and ghrelin levels remained unchanged at T1. The effect of sleep loss on GIT, fT3 and fT4 levels was inversely related to fat mass.
  
  
  CONCLUSIONS
  Short-term sleep deprivation increased energy intake and led to a net weight gain in women. The effect of sleep restriction on energy expenditure needs to be specifically addressed in future studies using reference methods for total energy expenditure.
authors.affiliation: Institut für Humanernahrung und Lebensmittelkunde, Christian-Albrechts-University Kiel, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Bosy-Westphal
authors.forename: Silvia
authors.initials: S
authors.lastname: Hinrichs
authors.forename: Kamila
authors.initials: K
authors.lastname: Jauch-Chara
authors.forename: Britta
authors.initials: B
authors.lastname: Hitze
authors.forename: Wiebke
authors.initials: W
authors.lastname: Later
authors.forename: Britta
authors.initials: B
authors.lastname: Wilms
authors.forename: Uta
authors.initials: U
authors.lastname: Settler
authors.forename: Achim
authors.initials: A
authors.lastname: Peters
authors.forename: Dieter
authors.initials: D
authors.lastname: Kiosz
authors.forename: Manfred James
authors.initials: MJ
authors.lastname: Muller
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002149:Energy Intake / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology; D009490:Neurosecretory Systems / Q000378:metabolism; D009765:Obesity / Q000378:metabolism*; D012892:Sleep Deprivation / Q000378:metabolism*; D013963:Thyroid Hormones / Q000097:blood; D015430:Weight Gain / Q000502:physiology*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013963:Thyroid Hormones; D006854:Hydrocortisone