title: Phosphatase of regenerating liver-3: a novel and promising marker in human endometriosis.
abstract: OBJECTIVE
  To investigate the expression of phosphatase of regenerating liver-3 (PRL-3) in ectopic, eutopic, and normal endometria and explore its relationship with endometriosis.
  
  
  METHODS
  A clinical retrospective and molecular study.
  
  
  METHODS
  Department of obstetrics, gynecology, and reproductive medicine.
  
  
  METHODS
  One hundred and five women with histopathologically confirmed endometriosis, and 50 women with histopathologically assessed normal endometria.
  
  
  METHODS
  Immunohistochemical staining and Western blot analysis.
  
  
  METHODS
  Expression of PRL-3 protein.
  
  
  RESULTS
  As shown by the immunohistochemical analysis, PRL-3 was mainly located in the cytoplasm and membrane. The cells that tested positive for PRL-3 were detected in endometriotic tissues that did not occur in eutopic and normal endometria. Statistical analysis indicated that the expression of PRL-3 was closely associated with the clinical stages and recurrence of endometriosis.
  
  
  CONCLUSIONS
  Expression of PRL-3 is related to the clinical stages and recurrence of endometriosis, which provides use with a novel marker and promising target in the treatment of human endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Ruan
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
authors.forename: Rui-Jin
authors.initials: RJ
authors.lastname: Wu
authors.forename: Kai-Hong
authors.initials: KH
authors.lastname: Xu
authors.forename: Xin-Mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: Zhou
authors.forename: Xiu-Feng
authors.initials: XF
authors.lastname: Huang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D015153:Blotting, Western; D004715:Endometriosis / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism / Q000502:physiology*; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism / Q000502:physiology*; D014591:Uterine Diseases / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D009363:Neoplasm Proteins; C484730:PTP4A3 protein, human; D017027:Protein Tyrosine Phosphatases