Synthesis and configurational stability of (S)- and (R)-deuteriothalidomides.
3'-Deuteriothalidomide was synthesized and found to be configurationally five times more stable than thalidomide toward racemization at physiological pH.
Yamamoto
Takeshi
T
Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Nagoya, Japan.
Tokunaga
Etsuko
E
Nakamura
Shuichi
S
Shibata
Norio
N
Toru
Takeshi
T
D003903:Deuterium / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013723:Teratogens / Q000138:chemical synthesis / Q000737:chemistry*; D013792:Thalidomide / Q000138:chemical synthesis / Q000737:chemistry*
D013723:Teratogens; D013792:Thalidomide; D003903:Deuterium