title: The number of lung transplants can be safely doubled using extended criteria donors; a single-center review.
abstract: Relaxing the standard lung donor criteria may significantly increase the reported 15% organ yield but post-transplant recipient outcome should be carefully monitored. Charts from all consecutive deceased organ donors within our hospital network were reviewed over a 2-year period. Reasons for lung refusals and number of lungs transplanted were analysed. Hospital outcome including early recipient survival was compared between standard- and extended criteria donors. Out of 283 referrals, 164 (58%) qualified as donor of any organ. The majority (65.9%) of these effective donors were declined for lung donation because of chest X-ray abnormalities (20%), age >70 years (13%), poor oxygenation (10%), or aspiration (9%). Out of 56 (34.1%) accepted lung donors, 50 transplants were performed at our center, 23 from standard criteria donors versus 27 from extended criteria donors. There were no significant differences in hospital outcome and in early survival between lung recipients from both donor groups. Lung acceptance rate (34.1%) in our donor network is 10-20% higher than reported figures. The number of lung transplants in our center doubled by accepting extended criteria donors. This policy did not negatively influence our results after lung transplantation.
authors.affiliation: Department of Thoracic Surgery, University Hospital Gasthuisberg, Leuven, Belgium.
authors.forename: Caroline
authors.initials: C
authors.lastname: Meers
authors.forename: Dirk
authors.initials: D
authors.lastname: Van Raemdonck
authors.forename: Geert M
authors.initials: GM
authors.lastname: Verleden
authors.forename: Willy
authors.initials: W
authors.lastname: Coosemans
authors.forename: Herbert
authors.initials: H
authors.lastname: Decaluwe
authors.forename: Paul
authors.initials: P
authors.lastname: De Leyn
authors.forename: Philippe
authors.initials: P
authors.lastname: Nafteux
authors.forename: Toni
authors.initials: T
authors.lastname: Lerut
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006085:Graft Survival; D006801:Humans; D008168:Lung / Q000473:pathology; D016040:Lung Transplantation / Q000401:mortality / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D012907:Smoking; D014019:Tissue Donors / Q000706:statistics & numerical data*; D009927:Tissue and Organ Procurement / Q000592:standards*; D016896:Treatment Outcome