title: Genistein up-regulates the iron efflux system in glial cells.
abstract: Astrocytes accumulate iron under chronic oxidative stress conditions in ageing and neurological disorders. The soybean isoflavone genistein possesses antioxidant properties and selective estrogen-like activities. Here, a possible role of genistein in modulation of iron transport was explored in glial cells. Genistein significantly increased iron export through estrogen receptor-beta-dependent p38 MAPK activation. Evidence is presented that this effect is associated to a p38 MAPK-triggered up-regulation of the iron export system made by ceruloplasmin and ferroportin-1, a pathway requiring activation of the transcription factor C/EBP.
authors.affiliation: Department Biology, Università Roma Tre, 00146, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Persichini
authors.forename: Nunziata
authors.initials: N
authors.lastname: Maio
authors.forename: Maria Carmela Bonaccorsi
authors.initials: MC
authors.lastname: di Patti
authors.forename: Gianluca
authors.initials: G
authors.lastname: Rizzo
authors.forename: Marco
authors.initials: M
authors.lastname: Colasanti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Musci
mesh_terms: D022763:CCAAT-Enhancer-Binding Protein-alpha / Q000378:metabolism; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000378:metabolism; D027682:Cation Transport Proteins / Q000378:metabolism; D045744:Cell Line, Tumor; D002570:Ceruloplasmin / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000378:metabolism; D019833:Genistein / Q000494:pharmacology*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008297:Male; D009457:Neuroglia / Q000187:drug effects* / Q000378:metabolism*; D048789:Phytoestrogens / Q000494:pharmacology*; D015854:Up-Regulation / Q000187:drug effects; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000098742:Ferroportin
chemical_list: D022763:CCAAT-Enhancer-Binding Protein-alpha; D022782:CCAAT-Enhancer-Binding Protein-beta; D027682:Cation Transport Proteins; D047629:Estrogen Receptor beta; D048789:Phytoestrogens; D000098742:Ferroportin; D019833:Genistein; D007501:Iron; D002570:Ceruloplasmin; D048051:p38 Mitogen-Activated Protein Kinases