title: Selective brain cooling with endovascular intracarotid infusion of cold saline: a pilot feasibility study.
abstract: OBJECTIVE
  Endovascular brain cooling as a method for rapid and selective induction of hypothermic neuroprotection has not been systematically studied in humans. In this clinical pilot study we investigated the feasibility, safety, and physiologic responses of short-term brain cooling with IC-CSI.
  
  
  METHODS
  We studied 18 patients (50 +/- 10 years old, 9 women) undergoing follow-up cerebral angiography after previous treatment of vascular malformations. Isotonic saline (4-17 degrees C) was infused into 1 internal carotid artery at 33 mL/min for 10 minutes. Brain (JVB) and bladder/esophageal temperature measurements (n = 9) were performed. Both MCAs were monitored with transcranial Doppler sonography (n = 13). Arterial and JV blood were sampled to estimate hemodilution and brain oxygen extraction.
  
  
  RESULTS
  JVB temperature dropped approximately 0.84 +/- 0.13 degrees C and systemic temperature by 0.15 +/- 0.08 degrees C from baseline (JVB versus systemic temperature: P = .0006). Systolic MCA-flow velocities decreased from 101 +/- 27 to 73 +/- 18 cm/s on the infused side and from 83 +/- 24 to 78 +/- 21 cm/s on the contralateral side (relative changes, -26 +/- 8% versus -4 +/- 27%; P = .009). Changes in hematocrit (-1.2 +/- 1.1%) and cerebral arteriovenous oxygen difference (0.2 +/- 1.0 mL O(2)/100 mL) were not significant. Doppler data showed no signs of vascular spasm or microemboli. No focal neurologic deficits occurred. Pain was not reported.
  
  
  CONCLUSIONS
  The results of this pilot study suggest that brain cooling can be achieved safely, rapidly, and selectively by means of IC-CSI, opening a new potential avenue for acute neuroprotection. Clinical investigations with control of infusion parameters and measurements of CBF, oxygen consumption, and brain temperature are warranted.
authors.affiliation: Department of Radiology, Interventional Neuroradiology, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York 10032, USA. jhc2117@columbia.edu
authors.forename: J H
authors.initials: JH
authors.lastname: Choi
authors.forename: R S
authors.initials: RS
authors.lastname: Marshall
authors.forename: M A
authors.initials: MA
authors.lastname: Neimark
authors.forename: A A
authors.initials: AA
authors.lastname: Konstas
authors.forename: E
authors.initials: E
authors.lastname: Lin
authors.forename: Y T
authors.initials: YT
authors.lastname: Chiang
authors.forename: H
authors.initials: H
authors.lastname: Mast
authors.forename: T
authors.initials: T
authors.lastname: Rundek
authors.forename: J P
authors.initials: JP
authors.lastname: Mohr
authors.forename: J
authors.initials: J
authors.lastname: Pile-Spellman
mesh_terms: D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D004453:Echoencephalography; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D007261:Infusions, Intra-Arterial; D008297:Male; D010865:Pilot Projects; D012965:Sodium Chloride / Q000008:administration & dosage*; D016896:Treatment Outcome; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D012965:Sodium Chloride