No association between the GSTP1 exon 5 polymorphism and susceptibility to advanced stage endometriosis in the Korean population.
OBJECTIVE
To investigate whether the glutathione-S-transferase P1 (GSTP1) exon 5 polymorphism is associated with susceptibility to advanced stage endometriosis in Korean women.


METHODS
Case-control study in a collective of 260 patients and 164 controls. Genotyping of the GSTP1 exon 5 polymorphism was performed by using real-time TaqMan PCR assay.


RESULTS
The genotype distribution of the GSTP1 exon 5 polymorphism in the endometriosis group was not significantly different from that of the control group (AA/AG/GG rates were 64.2%/32.7%/3.1% and 65.2%/31.7%/3.0% for the endometriosis and control groups, respectively, P = 0.977). Further subgroup analysis according to either stage or bilaterality of ovarian endometrioma also found no significant difference in the genotype distribution between any of the endometriosis subgroups and the control group.


CONCLUSIONS
These findings suggest that the GSTP1 exon 5 polymorphism is not a major determinant of the development of advanced stage endometriosis in the Korean population.
Jeon
Myung Jae
MJ
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yungun-dong, Chongno-ku, Seoul, South Korea.
Choi
Young Min
YM
Hong
Min A
MA
Lee
Gyoung Hoon
GH
Ku
Seung Yup
SY
Kim
Seok Hyun
SH
Kim
Jung Gu
JG
Moon
Shin Yong
SY
D000328:Adult; D044466:Asian People / Q000235:genetics; D004715:Endometriosis / Q000235:genetics*; D005091:Exons / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D007723:Korea; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA
C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi