Association between low pulmonary function and metabolic risk factors in Korean adults: the Korean National Health and Nutrition Survey.
Impaired lung function is a risk factor for cardiovascular events and mortality. In addition, lung function impairment is also associated with insulin resistance and type 2 diabetes mellitus. It is well known that a common mechanism, such as insulin resistance and obesity, underlies metabolic syndrome. Our aim was to evaluate the association between impaired lung function and metabolic risk factors using data from a nationwide survey of chronic obstructive pulmonary disease prevalence in Korea and the Korean National Health and Nutrition Survey in 2001. The study population included 4001 subjects (aged > or =18 years) who underwent spirometry at least twice. We analyzed the association of low pulmonary function with metabolic syndrome components using multiple linear regression and also analyzed the association of metabolic syndrome with restrictive lung disease and obstructive lung disease using multiple logistic regression adjusted for waist to height ratio, sex, age, smoking, and the other covariates. Waist girth, systolic blood pressure, and triglyceride were associated with forced vital capacity (FVC); and only triglyceride was so with forced expiratory volume in 1 second (FEV(1)), but not with FEV(1)/FVC ratio. The odds ratio of metabolic syndrome for restrictive lung disease (FVC <80%, FEV(1)/FVC >0.7) was 1.40 (95% confidence interval, 1.01-1.98), and that for obstructive lung disease (FEV(1)/FVC <0.7) was 0.93 (95% confidence interval, 0.67-1.28) after adjustment for covariates. These results indicate that low pulmonary function in the general population is associated with clustering of metabolic syndrome risk factors and, furthermore, that restrictive lung disease is also related to metabolic syndrome.
Paek
Yu-Jin
YJ
Department of Family Medicine, Health Promotion Center, Hallym University Sacred Heart Hospital, Gyeonggi 431-070, South Korea.
Jung
Ki-Suck
KS
Hwang
Young-Il
YI
Lee
Kang-Sook
KS
Lee
Dong Ryul
DR
Lee
Jung-Un
JU
D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D001786:Blood Glucose; D015992:Body Mass Index; D006306:Health Surveys; D006801:Humans; D007333:Insulin Resistance; D007723:Korea; D016015:Logistic Models; D008168:Lung / Q000503:physiopathology*; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D013147:Spirometry; D011795:Surveys and Questionnaires
D001786:Blood Glucose