title: Primary immune-mediated thrombocytopenia in cats.
abstract: Feline primary immune-mediated thrombocytopenia (pIMT) is a rare condition, and only a few cases have been described in veterinary literature. Five cats with severe thrombocytopenia most likely due to pIMT are described. A flow cytometry platelet-bound antibody test was positive in all cats; underlying diseases or triggering factors causing thrombocytopenia were not detected. Three cats were transfused with blood type-compatible fresh whole blood; one cat received Oxyglobin as well. All cats were treated with prednisolone; one cat received chlorambucil in addition. Four cats responded to treatment and were discharged from the hospital. One cat was euthanized due to dyspnea. Primary immune-mediated thrombocytopenia is rarely diagnosed in cats, but it is important as a differential diagnosis in cats presented with surface bleeding.
authors.affiliation: Clinic for Small Animals, Faculty of Veterinary Medicine, Free University of Berlin, Oertzenweg 19b, Berlin, 14163, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Wondratschek
authors.forename: Christiane
authors.initials: C
authors.lastname: Weingart
authors.forename: Barbara
authors.initials: B
authors.lastname: Kohn
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000097:blood / Q000276:immunology / Q000628:therapy / Q000662:veterinary*; D001792:Blood Platelets / Q000276:immunology*; D001803:Blood Transfusion / Q000662:veterinary; D002371:Cat Diseases / Q000097:blood* / Q000276:immunology* / Q000628:therapy; D002415:Cats; D005260:Female; D005434:Flow Cytometry; D006454:Hemoglobins / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D010976:Platelet Count / Q000662:veterinary; D011239:Prednisolone / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000276:immunology / Q000628:therapy / Q000662:veterinary*; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D006454:Hemoglobins; D007166:Immunosuppressive Agents; C402601:hemoglobin glutamer-200; D011239:Prednisolone