title: [The polymorphism of bovine POMC gene and its association with the growth traits of Nanyang cattle].
abstract: Pro-opiomelanocortin (POMC) plays an important role on animal ingestive behavior and energy homeostasis. Genetic variation of POMC was detected by PCR-SSCP and DNA sequencing techniques in 480 individuals from seven cattle breeds (i.e., Qinchuan, Nanyang, Jiaxian Red cattle, Jinnan, Luxi, Angus, and Chinese Holstein), and association analyses were carried out to evaluate the effects of genotypes of the candidate genes on growth traits in Nanyang cattle. Three SNPs (811845 C>T, 811821 T>C and 811797 A>G, ref. NW_928357) in linkage were detected in P3 locus, which were located at the 3' flanking region of bovine POMC gene. The body weight at 6-month-old and the average daily gain of 0~6-month-old were higher in Nanyang cattle with the genotype BB than with the genotype AA (P<0.05).
authors.affiliation: Institute of Cellular and Molecular Biology, Xuzhou Normal University, Xuzhou 221116, China. clzhang_xz@126.com
authors.forename: Chun-Lei
authors.initials: CL
authors.lastname: Zhang
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Chu-Zhao
authors.initials: CZ
authors.lastname: Lei
authors.forename: Xing-Tang
authors.initials: XT
authors.lastname: Fang
authors.forename: Ju-Qiang
authors.initials: JQ
authors.lastname: Wang
authors.forename: Gui-Bian
authors.initials: GB
authors.lastname: Ma
authors.forename: Hui
authors.initials: H
authors.lastname: Niu
authors.forename: Jie
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000818:Animals; D001483:Base Sequence; D002417:Cattle / Q000235:genetics* / Q000254:growth & development*; D002681:China; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D008297:Male; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D011333:Pro-Opiomelanocortin / Q000235:genetics*; D019655:Quantitative Trait, Heritable
chemical_list: D011333:Pro-Opiomelanocortin