title: Evalution of anti-ulcer activity of Polyalthia longifolia (Sonn.) Thwaites in experimental animals.
abstract: OBJECTIVE
  To evaluate the anti-ulcer activity of ethanol extract of leaves of Polyalthia longifolia (Sonn.) Thwaites.
  
  
  METHODS
  The ethanol extract of Polyalthia longifolia was investigated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer in rats, HCl -Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats at 300 mg/kg body weight.p.o.
  
  
  RESULTS
  A significant (P < 0.01, P < 0.001) anti ulcer activity was observed in all the models. Pylorous ligation showed significant (P< 0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. It also showed 89.71% ulcer inhibition in HCl- Ethanol induced ulcer and 95.3% ulcer protection index in stress induced ulcer.
  
  
  CONCLUSIONS
  This present study indicates that P. longifolia leaves extract have potential anti ulcer activity in the three models tested.
authors.affiliation: Rofel Shri GM Bilakhia College of Pharmacy, Vapi (West)-396 191, Gujarat State, India.
authors.forename: P
authors.initials: P
authors.lastname: Malairajan
authors.forename: Geetha
authors.initials: G
authors.lastname: Gopalakrishnan
authors.forename: S
authors.initials: S
authors.lastname: Narasimhan
authors.forename: K Jessi Kala
authors.initials: KJ
authors.lastname: Veni