Scribble at the crossroads.
Although proteins involved in determining apical-basal cell polarity have been directly linked to tumorigenesis, their precise roles in this process remain unclear. A recent report in BMC Biology clarifies the signaling pathways that control cell polarity, proliferation and apoptosis downstream of the tumor suppressor and apical-basal polarity determinant Scribble.
Etienne-Manneville
Sandrine
S
Institut Pasteur, Cell Polarity and Migration Group and CNRS URA 2582, 25 rue du Dr Roux, 75724 Paris cedex 15, France. sandrine.etienne-manneville@pasteur.fr
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology*; D049109:Cell Proliferation; D029721:Drosophila Proteins / Q000502:physiology; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000502:physiology*
D029721:Drosophila Proteins; D025521:Tumor Suppressor Proteins