Paraoxonase 1 (PON1) polymorphisms and risk for essential tremor.
BACKGROUND
The polymorphic enzyme human serum paraoxonase 1 (PON1), encoded by the gene PON1 (chromosome 7q21.3), plays a major role in the metabolism of organophosphorus compounds. We investigated the possible association between the PON1 genotype and allelic variants of the polymorphisms Leu55Met and Glu192Arg, and the risk for essential tremor (ET).


METHODS
We studied the frequency of the PON1 genotypes and allelic variants in 201 patients with ET and 220 healthy controls using a PCR-RLFP method.


RESULTS
The frequencies of the PON1 genotypes and allelic variants of the polymorphisms Leu55Met and Gln192Arg did not differ significantly between patients with ET and controls. These polymorphisms were unrelated with the age of onset of ET.


CONCLUSIONS
PON1 polymorphisms are not related with the risk for ET.
García-Martín
E
E
Biochemistry and Molecular Biology, School of Biological Sciences, University of Extremadura, Badajoz, Spain.
Martínez
C
C
Alonso-Navarro
H
H
Benito-León
J
J
Puertas
I
I
Rubio
L
L
López-Alburquerque
T
T
Agúndez
J A G
JA
Jiménez-Jiménez
F J
FJ
D000368:Aged; D043303:Aryldialkylphosphatase / Q000235:genetics*; D020329:Essential Tremor / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D043303:Aryldialkylphosphatase; C468406:PON1 protein, human