title: Claudin-5 overexpression correlates with aggressive behavior in serous ovarian adenocarcinoma.
abstract: BACKGROUND
  Claudins are essential tight junctional proteins between adjacent epithelial, mesothelial or endothelial cells, and are responsible for the permeability of the paracellular space. The expression of claudin-5 and its correlation to ovarian cancer behavior was investigasted.
  
  
  METHODS
  A total of 85 serous ovarian cancer tissue samples were analyzed using immunohistochemical staining.
  
  
  RESULTS
  An association between claudin-5 expression and cancer grade (p=0.016) and advanced stage (p=0.022), strongest claudin-5 expression was found in advanced stage and high-grade carcinomas. An association between claudin-5 expression and cancer-specific (p=0.032) and overall survival (p=0.026) was also found. Only 25-30% of claudin-5-positive patients, but 60% of claudin-5-negative patiens were alive at the 5-years follow-up.
  
  
  CONCLUSIONS
  Increased claudin-5 expression is associated with aggressive behavior in serous ovarian adenocarcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, 90014 University of Oulu, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Turunen
authors.forename: A
authors.initials: A
authors.lastname: Talvensaari-Mattila
authors.forename: Y
authors.initials: Y
authors.lastname: Soini
authors.forename: M
authors.initials: M
authors.lastname: Santala
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000378:metabolism* / Q000556:secondary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D062507:Claudin-5; D018284:Cystadenocarcinoma, Serous / Q000378:metabolism* / Q000556:secondary; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C107466:CLDN5 protein, human; D062507:Claudin-5; D008565:Membrane Proteins