Subcellular targeting strategies for drug design and delivery.
Many drug targets are localized to particular subcellular compartments, yet current drug design strategies are focused on bioavailability and tissue targeting and rarely address drug delivery to specific intracellular compartments. Insights into how the cell traffics its constituents to these different cellular locations could improve drug design. In this Review, we explore the fundamentals of membrane trafficking and subcellular organization, as well as strategies used by pathogens to appropriate these mechanisms and the implications for drug design and delivery.
Rajendran
Lawrence
L
Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, Zurich, Switzerland. rajendran@bli.uzh.ch
Knölker
Hans-Joachim
HJ
Simons
Kai
K
D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D016503:Drug Delivery Systems; D015195:Drug Design; D004345:Drug Industry / Q000379:methods; D006801:Humans; D013347:Subcellular Fractions / Q000378:metabolism