Synthesis of 1-(1H-indol-3-yl)-1,2-dihydroisoquinolines via AgOTf-catalyzed three-component reactions of 2-alkynylbenzaldehydes, amines, and indoles.
Three-component reactions of 2-alkynylbenzaldehydes, amines, and indoles catalyzed by AgOTf under mild conditions afford the 1-(1H-indol-3-yl)-1,2-dihydroisoquinolines in good yields. This silver-catalyzed tandem reaction is found to be workable with various indoles, anilines or alkyl amines, and 2-alkynylbenzaldehydes with electron-withdrawing groups attached on the aromatic backbone.
Yu
Xingxin
X
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
Wu
Jie
J
D000588:Amines / Q000737:chemistry*; D001547:Benzaldehydes / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis*
D000588:Amines; D001547:Benzaldehydes; D007211:Indoles; D007546:Isoquinolines