Genetics of mammalian meiosis: regulation, dynamics and impact on fertility.
Meiosis is an essential stage in gamete formation in all sexually reproducing organisms. Studies of mutations in model organisms and of human haplotype patterns are leading to a clearer understanding of how meiosis has adapted from yeast to humans, the genes that control the dynamics of chromosomes during meiosis, and how meiosis is tied to gametic success. Genetic disruptions and meiotic errors have important roles in infertility and the aetiology of developmental defects, especially aneuploidy. An understanding of the regulation of meiosis, coupled with advances in genomics, may ultimately allow us to diagnose the causes of meiosis-based infertilities, more wisely apply assisted reproductive technologies, and derive functional germ cells.
Handel
Mary Ann
MA
The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. maryann.handel@jax.org
Schimenti
John C
JC
D000818:Animals; D003434:Crossing Over, Genetic; D005298:Fertility / Q000235:genetics*; D005854:Germ Cells / Q000502:physiology; D006801:Humans; D008322:Mammals / Q000235:genetics; D008540:Meiosis / Q000235:genetics*; D008957:Models, Genetic