title: Synthesis, antitumor evaluation and crystal structure of hydroxyurea derivatives.
abstract: A series of hydroxyurea derivatives have been synthesized and elucidated by means of FT-IR, (1)H-, (13)C-NMR and MS. The exact stereostructures of representative compounds have been determined by X-ray crystal structure analysis. In the crystals, inversion dimers linked by pairs of N-H...O hydrogen bonds occurred, and further N-H...O links led to chains of molecules. In vitro antitumor activities against Tca8113 human tongue cancer cells and L1210 murine leukemia cells were evaluated. A total of 8 of the 12 compounds had higher inhibitory activities than hydroxyurea against L1210 cells. Among them, the most promising compounds were 3e, 3d, 3a and 2d.
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Mai
authors.forename: Xiaosan
authors.initials: X
authors.lastname: Lu
authors.forename: Hongying
authors.initials: H
authors.lastname: Xia
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Cao
authors.forename: Yijing
authors.initials: Y
authors.lastname: Liao
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Lv
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D006801:Humans; D006918:Hydroxyurea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D007938:Leukemia / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D014062:Tongue Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D006918:Hydroxyurea