title: Is there a link between wheezing in early childhood and adverse birth outcomes? A systematic review.
abstract: We aimed to provide a summary of the existing published knowledge on the association between adverse birth outcomes and the development of wheezing during the first two years of life. We carried out a systematic review of epidemiological studies within the MEDLINE database. Epidemiological studies on human subjects, published in English, were included in the review. A comprehensive literature search yielded 72 studies for further consideration. Following the application of the eligibility criteria we identified nine studies. A positive association and an excess risk of wheezing during the first two years of life were revealed for adverse birth outcomes.
authors.affiliation: University Hospital of Heraklion, Crete, Greece. patelarou@edu.med.uoc.gr
authors.forename: Evridiki
authors.initials: E
authors.lastname: Patelarou
authors.forename: Maria
authors.initials: M
authors.lastname: Chochlidaki
authors.forename: Victoria
authors.initials: V
authors.lastname: Vivilaki
authors.forename: Hero
authors.initials: H
authors.lastname: Brokalaki
mesh_terms: D000367:Age Factors; D001249:Asthma / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D011247:Pregnancy; D011248:Pregnancy Complications; D015995:Prevalence; D012135:Respiratory Sounds / Q000209:etiology*; D012140:Respiratory Tract Diseases / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors; D013997:Time Factors