Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase.
Series of perfluoroalkanesulfonamides 1, sodium salt of perfluoroalkanesulfonamides 2 and polyfluoroalkanesulfonamides 3 derivatives were synthesized and characterized by (1)H NMR, (13)C NMR, (19)F NMR, IR and HRMS. Inhibition effects of these compounds on bovine carbonic anhydrase (bCA) and human carbonic anhydrase isoenzyme II (hCA) have been investigated. Comparing IC(50) values of the synthesized molecules 1, 2 and 3, it has been found that compound 2b is a more potent inhibitor than acetazolamide on hCA. Moreover 2b does not present cellular toxicity on sheep red globules.
Benfodda
Zohra
Z
Institut des Biomolécules Max Mousseron UMR CNRS 5247 Université de Montpellier I et de Montpellier II, CC1706, Place Eugène Bataillon 34095 Montpellier cedex 05, France.
Guillen
Franck
F
Romestand
Bernard
B
Dahmani
Abdelkader
A
Blancou
Hubert
H
D000641:Ammonia / Q000737:chemistry; D000818:Animals; D024402:Carbonic Anhydrase II / Q000037:antagonists & inhibitors*; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D002256:Carbonic Anhydrases / Q000737:chemistry*; D002417:Cattle; D004789:Enzyme Activation / Q000187:drug effects; D005740:Gases; D006801:Humans; D015394:Molecular Structure; D012756:Sheep; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D002257:Carbonic Anhydrase Inhibitors; D005740:Gases; D013449:Sulfonamides; D000641:Ammonia; D024402:Carbonic Anhydrase II; D002256:Carbonic Anhydrases