title: [Cardiotoxicity induced by 5-fluorouracil or capecitabine].
abstract: 5-fluorouracil and capecitabine have significant antineoplastic activity towards various solid tumors. Cardiotoxicity causing angina, arrhythmia and infarction are serious adverse events associated with these agents. The pathogenesis is discussed and symptoms of cardiotoxicity, intervention with nitroglycerine and risk factors as cardiac comorbidity are described. Following cardiotoxicity, lack of alternative active agents may provide grounds to rechallenge with 5-FU. In this situation, dose-modified 5-FU-based chemotherapy supported by medical antiangina prevention is feasible.
authors.affiliation: Onkologisk Afdeling 5073, Rigshospitalet, DK-2100 København Ø, Denmark. soren.a.jensen@mail.tele.dk
authors.forename: Søren Astrup
authors.initials: SA
authors.lastname: Jensen
authors.forename: Lene
authors.initials: L
authors.lastname: Baeksgaard
authors.forename: Lone Nørgaard
authors.initials: LN
authors.lastname: Petersen
authors.forename: Lars
authors.initials: L
authors.lastname: Reiter
authors.forename: Jens Benn
authors.initials: JB
authors.lastname: Sørensen
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D000069287:Capecitabine; D015179:Colorectal Neoplasms / Q000188:drug therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives; D005996:Nitroglycerin / Q000008:administration & dosage; D011355:Prodrugs; D012307:Risk Factors; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D011355:Prodrugs; D014665:Vasodilator Agents; D003841:Deoxycytidine; D000069287:Capecitabine; D005996:Nitroglycerin; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate; D005472:Fluorouracil