title: Association of estrogen receptor-alpha gene polymorphisms with cardiac autonomic nervous activity in healthy young Japanese males.
abstract: BACKGROUND
  Estrogens exert beneficial effects on the cardiovascular system that are mediated by estrogen receptors. We examined the association between the estrogen receptor alpha gene (ESR1) PvuII and XbaI polymorphisms and cardiac autonomic nervous function in Japanese males.
  
  
  METHODS
  We examined 252 young healthy males for association of ESR1 PvuII and XbaI polymorphisms and short-term heart rate variability (HRV) during supine rest and in a standing position. The very low frequency (VLF), low frequency (LF), and high frequency (HF) components of HRV were quantified by frequency domain analysis.
  
  
  RESULTS
  Carriers of the ESR1 PvuII C allele had higher mean blood pressure (BP), while the XbaI GG genotype was significantly associated with higher diastolic and mean BP, but lower HR. In the haplotype analysis, carriers of the ESR1 haplotype 2 (PvuII C and XbaI A) allele had a higher systolic and mean BP, and lower HRV spectral powers (total power, VLF, LF, and HF components) in a supine rest compared with those of non-carriers.
  
  
  CONCLUSIONS
  The ESR1 PvuII and XbaI haplotype is associated with BP variation and the reduction in cardiac autonomic nervous activity in young Japanese males, which may be precursors of future pathological episodes of cardiovascular diseases.
authors.affiliation: Kyoto University, Japan. dmmed-028@umin.ac.jp
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Ning
authors.initials: N
authors.lastname: Gu
authors.forename: Hanae
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Adachi
authors.forename: Koichiro
authors.initials: K
authors.lastname: Yasuda
authors.forename: Toshio
authors.initials: T
authors.lastname: Moritani
authors.forename: Kinsuke
authors.initials: K
authors.lastname: Tsuda
authors.forename: Tohru
authors.initials: T
authors.lastname: Nishiyama
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nonaka
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D001341:Autonomic Nervous System / Q000378:metabolism*; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics* / Q000378:metabolism; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D012016:Reference Values; D055815:Young Adult
chemical_list: C025580:endodeoxyribonuclease XBAI; C025630:CAGCTG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific