Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case-control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case-control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate-adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19-2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12-1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52-1.31), breast cancer (OR = 1.21, 95% CI = 0.97-1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93-1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.
Jacobs
Eric J
EJ
Department of Epidemiology, American Cancer Society, Atlanta, GA, USA. ejacobs@cancer.org
Chanock
Stephen J
SJ
Fuchs
Charles S
CS
Lacroix
Andrea
A
McWilliams
Robert R
RR
Steplowski
Emily
E
Stolzenberg-Solomon
Rachael Z
RZ
Arslan
Alan A
AA
Bueno-de-Mesquita
H Bas
HB
Gross
Myron
M
Helzlsouer
Kathy
K
Petersen
Gloria
G
Zheng
Wei
W
Agalliu
Ilir
I
Allen
Naomi E
NE
Amundadottir
Laufey
L
Boutron-Ruault
Marie-Christine
MC
Buring
Julie E
JE
Canzian
Federico
F
Clipp
Sandra
S
Dorronsoro
Miren
M
Gaziano
J Michael
JM
Giovannucci
Edward L
EL
Hankinson
Susan E
SE
Hartge
Patricia
P
Hoover
Robert N
RN
Hunter
David J
DJ
Jacobs
Kevin B
KB
Jenab
Mazda
M
Kraft
Peter
P
Kooperberg
Charles
C
Lynch
Shannon M
SM
Sund
Malin
M
Mendelsohn
Julie B
JB
Mouw
Tracy
T
Newton
Christina C
CC
Overvad
Kim
K
Palli
Domenico
D
Peeters
Petra H M
PH
Rajkovic
Aleksandar
A
Shu
Xiao-Ou
XO
Thomas
Gilles
G
Tobias
Geoffrey S
GS
Trichopoulos
Dimitrios
D
Virtamo
Jarmo
J
Wactawski-Wende
Jean
J
Wolpin
Brian M
BM
Yu
Kai
K
Zeleniuch-Jacquotte
Anne
A
D016022:Case-Control Studies; D015331:Cohort Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000235:genetics