Synthesis of polysubstituted 5-aminooxazoles from alpha-diazocarbonyl esters and alpha-isocyanoacetamides.
A novel and efficient reaction for the synthesis of 2-keto-5-aminooxazoles is developed. The entire sequence is realized by simply heating a xylene solution of alpha-diazocarbonyl esters and alpha-isocyanoacetamides without any promoters. A possible mechanism for the entire sequence is proposed.
Wu
Jianwei
J
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China.
Chen
Wenteng
W
Hu
Miao
M
Zou
Hongbin
H
Yu
Yongping
Y
D000081:Acetamides / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004952:Esters; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014992:Xylenes / Q000737:chemistry
D000081:Acetamides; D001391:Azo Compounds; D004952:Esters; D010080:Oxazoles; D014992:Xylenes