Association of toll-like receptor 2 gene polymorphisms with normal tension glaucoma.
OBJECTIVE
Toll-like receptor 2 (TLR2) is a transmembrane receptor that mediates immune responses to exogenous and endogenous ligands, and interacts with heat-shock proteins, which are reportedly involved in normal tension glaucoma (NTG). We investigated whether TLR2 polymorphisms are associated with NTG.


METHODS
200 Japanese patients with NTG and 128 healthy Japanese controls were recruited. We genotyped five single-nucleotide polymorphisms (SNPs) in the TLR2 gene and assessed the allele and haplotype diversities between cases and controls for all SNPs.


RESULTS
No significant differences in the frequency of TLR2 alleles and haplotypes in the NTG cases were detected, compared with the controls.


CONCLUSIONS
Our study showed no evidence for an association between TLR2 polymorphisms and NTG. TLR2 polymorphisms may not play an important role in NTG pathogenesis in the Japanese population.
Nakamura
Jutaro
J
Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
Meguro
Akira
A
Ota
Masao
M
Nomura
Eiichi
E
Nishide
Tadayuki
T
Kashiwagi
Kenji
K
Mabuchi
Fumihiko
F
Iijima
Hiroyuki
H
Kawase
Kazuhide
K
Yamamoto
Tetsuya
T
Nakamura
Makoto
M
Negi
Akira
A
Sagara
Takeshi
T
Nishida
Teruo
T
Inatani
Masaru
M
Tanihara
Hidenobu
H
Aihara
Makoto
M
Araie
Makoto
M
Fukuchi
Takeo
T
Abe
Haruki
H
Higashide
Tomomi
T
Sugiyama
Kazuhisa
K
Kanamoto
Takashi
T
Kiuchi
Yoshiaki
Y
Iwase
Aiko
A
Ohno
Shigeaki
S
Inoko
Hidetoshi
H
Mizuki
Nobuhisa
N
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D057066:Low Tension Glaucoma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D055815:Young Adult
C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2