Estimating time to steady state using the effective rate of drug accumulation.
Unless all of a drug is eliminated during each dosing interval, the plasma concentrations within a dosing interval will increase until the time course of change in plasma concentrations becomes invariant from one dosing interval to the next, resulting in steady state. A simple method for estimating drug concentration time to steady state based on multiple dose area under the plasma concentration-time curve and effective rate of drug accumulation is presented. Several point estimates and confidence intervals for time to 90% of steady state are compared, and a recommendation is made on how to summarize and present the results.
Panebianco
Deborah L
DL
Merck Research Laboratories, Clinical Pharmacology Statistics, North Wales, PA 19454-1099, USA. Deborah_panebianco@merck.com
Maes
Andrea
A
D019540:Area Under Curve; D015233:Models, Statistical; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010949:Plasma / Q000378:metabolism*; D013997:Time Factors
D004364:Pharmaceutical Preparations