title: alpha-Synuclein pathology in the spinal cord autonomic nuclei associates with alpha-synuclein pathology in the brain: a population-based Vantaa 85+ study.
abstract: In most subjects with Parkinson's disease and dementia with Lewy bodies, alpha-synuclein (alphaS) immunoreactive pathology is found not only in the brain but also in the autonomic nuclei of the spinal cord. However, neither has the temporal course of alphaS pathology in the spinal cord in relation to the brain progression been established, nor has the extent of alphaS pathology in the spinal cord been analyzed in population-based studies. Using immunohistochemistry, the frequency and distribution of alphaS pathology were assessed semiquantitatively in the brains and spinal cord nuclei of 304 subjects who were aged at least 85 in the population-based Vantaa 85+ study. alphaS pathology was common in the spinal cord; 102 (34%) subjects had classic alphaS pathology in the thoracic and/or sacral autonomic nuclei. Moreover, 134 (44%) subjects showed grain- or dot-like immunoreactivity in neuropil (mini-aggregates) without classic Lewy neurites or Lewy bodies (LBs). The latter type of alphaS accumulation is associated with age, but also the classic alphaS pathology was found more often in the oldest compared to the youngest age group. The severity of alphaS pathology in the spinal cord autonomic nuclei is significantly associated with the extent and severity of alphaS pathology in the brain. Of the subjects, 60% with moderate to severe thoracic alphaS pathology and up to 89% with moderate to severe sacral alphaS pathology had diffuse neocortical type of LB pathology in the brain. alphaS pathology exclusively in the spinal cord was rare. Our study indicates that in general alphaS pathology in the spinal cord autonomic nuclei is associated with similar pathology in the brain.
authors.affiliation: Department of Pathology, Helsinki University Central Hospital,University of Helsinki, P.O. Box 21, Haartmaninkatu 3, 00014 Helsinki, Finland. minna.oinas@helsinki.fi
authors.forename: Minna
authors.initials: M
authors.lastname: Oinas
authors.forename: Anders
authors.initials: A
authors.lastname: Paetau
authors.forename: Liisa
authors.initials: L
authors.lastname: Myllykangas
authors.forename: Irma-Leena
authors.initials: IL
authors.lastname: Notkola
authors.forename: Hannu
authors.initials: H
authors.lastname: Kalimo
authors.forename: Tuomo
authors.initials: T
authors.lastname: Polvikoski
mesh_terms: D000367:Age Factors; D000369:Aged, 80 and over; D001341:Autonomic Nervous System / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D001927:Brain Diseases / Q000378:metabolism / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D005387:Finland; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D019581:Neuropil / Q000378:metabolism / Q000473:pathology; D012445:Sacrococcygeal Region; D012720:Severity of Illness Index; D013116:Spinal Cord / Q000378:metabolism* / Q000473:pathology*; D013118:Spinal Cord Diseases / Q000378:metabolism / Q000473:pathology; D013904:Thoracic Vertebrae; D051844:alpha-Synuclein / Q000378:metabolism*
chemical_list: D051844:alpha-Synuclein