[Participation of glucocorticoid hormones in gastroprotection during ischemia and ischemia-reperfusion in rats].
The investigation concerned glucocorticoid hormones participation in gastroprotection during ischemia and ischemia-reperfusion in rats. Gastric ischemia was performed by occlusion of celiac artery in anaesthetized rats. The stomach was exposed to brief ischemia as well as brief or prolonged ischemia-reperfusion. Deficiency of glucocorticoid production (created by adrenalectomy or by metyrapone pretreatment) and occupation of glucocorticoid receptors by the antagonist RU-38486 were used to estimate the participation of glucocorticoids. Gastric ischemia and ischemia-reperfusion induced plasma corticosterone rise. The deficiency of corticosterone production as well as the occupation of glucocorticoid receptors resulted in aggravation of gastric mucosal damage produced by ischemia and ischemia-reperfusion. Thus, glucocorticoid hormones do participate in gastroprotection during ischemia and ischemia-reperfusion in rats.
Bobryshev
P Iu
PIu
Bagaeva
T R
TR
Filaretova
L P
LP
D000315:Adrenalectomy; D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D005938:Glucocorticoids / Q000037:antagonists & inhibitors / Q000097:blood*; D008297:Male; D015735:Mifepristone / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011965:Receptors, Glucocorticoid / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015427:Reperfusion Injury / Q000378:metabolism*
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D015735:Mifepristone