[Protecting effect of Chaenomeles speciosa broth on immunosuppressive mice induced by cyclophosphamide].
OBJECTIVE
To investigate the effects of Chaenomeles speciosa broth on immunoregulation for anti-tumor chemotherapy.


METHODS
Immunosuppressive model was induced by cyclophosphamide (CTX) in mice. The mice were treated with the broth for 15 days. The serum hemolysin was observed in mouse sera. Spleen lymphocyte transformation and gene transcription related to the immunoregulation in spleen lymphocytes were detected.


RESULTS
After administrated the broth, the serum hemolysin and lymphocyte transformation rates significantly increased and the mRNA expression of foxp3, TGF-beta, PD1, Fas, Bax were downregulated compared with CTX-group.


CONCLUSIONS
Chaenomeles speciosa broth has protective effects on the immunosuppressive mouse induce by CTX.
Shi
Ji-jing
JJ
Institute of Molecular Biology, China Three Gorges University, Yichang 443002, China. annashijijing@yahoo.com
Liu
Chao-qi
CQ
Li
Bin
B
Qin
Xiao-lin
XL
Chen
Jing
J
Wang
Jin-jiang
JJ
Yang
Fan
F
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003520:Cyclophosphamide / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005285:Fermentation; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D005638:Fruit / Q000737:chemistry; D005786:Gene Expression Regulation / Q000187:drug effects; D006460:Hemolysin Proteins / Q000097:blood; D007108:Immune Tolerance / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011897:Random Allocation; D027824:Rosaceae / Q000737:chemistry*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D006460:Hemolysin Proteins; D012333:RNA, Messenger; D003520:Cyclophosphamide