[The plasma level of sL-selectin, myeloperoxidase (MPO) and granulocyte-colony stimulating factor (G-CSF) in breast cancer patients after surgery].
G-CSF is a stimulatory factor of granulocyte colony formation. In vitro and in vivo G-CSF enhances functions of mature cells. Indirect evidence of this might be the increase of the activity of granulocyte enzymes participating in phagocytosis and killing tumor cells. The purpose of this investigation was to evaluate in the plasma of breast cancer patients the level of adhesion molecule - sL-selection, as a measure of mature granulocyte activity and MPO, granulocyte enzyme responsible for the cytotoxicity. Additionally we have investigated the plasma level of G-CSF which can increase in breast cancer. We tested 16 patients with I stage breast cancer and 15 patients with II stage breast cancer. Plasma samples were drawn before and 30 days after operation. The control group consisted of 10 healthy women. The plasma levels of sL-selectin, MPO and G-CSF were measured using breast cancer patients (I and II stage) before and after operation of sL-selection concentration was increased in comparison to the control group, but myeloperoxidase concentration was similar to the control group. These results suggest that levels of sL-selectin and MPO correlate with G-CSF concentration.
Czygier
Małgorzata
M
Zakład Diagnostyki Biochemicznej Akademii Medycznej w Białymstoku, Białystok.
Ławicki
Sławomir
S
Szmitkowski
Maciej
M
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D019041:L-Selectin / Q000097:blood*; D008875:Middle Aged; D009367:Neoplasm Staging; D009195:Peroxidase / Q000097:blood*; D011184:Postoperative Period
D014408:Biomarkers, Tumor; D019041:L-Selectin; D016179:Granulocyte Colony-Stimulating Factor; D009195:Peroxidase