title: Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice.
abstract: Our studies were performed to investigate the effects of the aqueous extracts of Cecropia pachystachya and Larrea divaricata. These plants are used in folkloric medicine in infusion and were administered orally (0.76 g/kg) to male Albino Swiss mice for 16 days, on drink intake, organ weight/body weight (OW/BW x 100) ratio, histology, broqueoalveolar fluid (BALF) and elevated plus-maze (EPM). Feeding as well as body weight were unaffected by the consumption of these extracts. There were no signs of toxicity in BALF, morbidity or mortality during the study. C. pachystachya caused an increase in relative kidney OW/BW (p <or= .05 vs control). The macroscopic and microscopic morphologic analyses of the organs were not altered by administration of these plants. A non-anxiolytic-like activity of an aqueous extract prepared from the leaves of C. pachystachya and L. divaricata in EPM was observed. We conclude that the crude aqueous extracts of leaves tested on mice orally did not produce signs of toxicity or behavioral changes in routine histological and clinical evaluation. However, knowledge of the biological activity of many herbal medicine used in Latin American is still deficient and more studies will be needed to elucidate the possible toxic effects.
authors.affiliation: Cátedra de Fisiología Humana, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.
authors.forename: M C
authors.initials: MC
authors.lastname: Bigliani
authors.forename: E
authors.initials: E
authors.lastname: Grondona
authors.forename: P M
authors.initials: PM
authors.lastname: Zunino
authors.forename: A A
authors.initials: AA
authors.lastname: Ponce
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001992:Bronchoalveolar Lavage Fluid; D035702:Cecropia Plant; D007668:Kidney / Q000033:anatomy & histology / Q000187:drug effects; D032442:Larrea; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects; D008168:Lung / Q000033:anatomy & histology / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D018515:Plant Leaves; D018709:Statistics, Nonparametric; D018675:Toxicity Tests
chemical_list: D010936:Plant Extracts