Deracemisation methods.
New methods continue to be developed for the dynamic kinetic resolution (DKR) and deracemisation of racemic chiral compounds, in particular alcohols, amines and amino acids. Many of the DKR processes involve the combination of an enantioselective enzyme, often a lipase or protease, with a metal racemisation catalyst. A greater range of ruthenium-based racemisation catalysts is now available with some showing good activity for the racemisation of amines that are more difficult to epimerise than the corresponding alcohols. In terms of deracemisation processes, further improvements have been achieved with the deracemisation of alcohols, using combinations of stereocomplementary ketoreductases, and additionally transaminases have been applied to the deracemisation of racemic amines.
Turner
Nicholas J
NJ
School of Chemistry, University of Manchester, Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester M1 7DN, UK. nicholas.turner@manchester.ac.uk
D000438:Alcohols / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D055162:Biocatalysis; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism
D000438:Alcohols; D000588:Amines; D000596:Amino Acids; D012428:Ruthenium