Serum adiponectin acutely after an ischemic stroke: implications for a long-lasting, suppressed anti-inflammatory role.
OBJECTIVE
Past ischemic stroke (IS) patients display suppressed adiponectin (ADPN) levels a few months after disease onset. It is still unclear whether hypoadiponectinemia is already present by the early stages of stroke or occurs as a delayed effect of the acute ischemic reaction. In the present study we investigated ADPN levels acutely after an IS.


METHODS
Serum ADPN was measured in 82 consecutive acute IS patients, and 30 stroke-free subjects of similar age and sex distributions.


RESULTS
Patients had significantly lower ADPN levels than controls. Higher ADPN was significantly associated with reduced odds for IS accounting for age, sex and high-density lipoproteins. This association was strengthened after further adjustments for potential confounders. ADPN levels remained suppressed even 6 months after stroke.


CONCLUSIONS
ADPN is significantly suppressed already by the early phases of stroke, and remains unchanged 6 months later. We propose a stable-over-time anti-inflammatory role of ADPN in IS, unrelated to the acute ischemic reaction.
Marousi
S
S
Department of Neurology, University Hospital of Patras, Greece.
Theodorou
G
G
Karakantza
M
M
Papathanasopoulos
P
P
Ellul
J
J
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D013997:Time Factors
D052242:Adiponectin; D000893:Anti-Inflammatory Agents