The preparation of magnetically guided lipid based nanoemulsions using self-emulsifying technology.
This paper reports an easy and highly reproducible preparation route, using self-emulsifying technology, for an orally administered high quality magnetically responsive drug delivery system. Hydrophobic iron oxide nanoparticles of about 5 nm in diameter were prepared and incorporated into the lipid core of the produced oil droplets of a self-nanoemulsifying drug delivery system (MagC(18)/SNEDDS). The produced nanoemulsion exhibits colloidal stability at high ionic strengths and temperatures. The observed value of the saturation magnetization at 2 K is approximately 4.1 emu g(-1). The nanoemulsion displayed the magnetic properties of a non-interacting assembly of superparamagnetic particles and a low blocking temperature. Moreover the effect of MagC(18)/SNEDDS on biological systems in vitro was investigated in rodent fibroblasts (3T3 cells). The cytotoxicity studies show that none of the formulations tested affected cell activity significantly over the 24 h incubation. Such systems might have a potential use for oral delivery of poorly soluble compounds by extending the residence time of the formulation in the small intestine resulting in increased drug absorption values.
Bakandritsos
Aristides
A
Department of Materials Science, University of Patras, 26504 Rio, Patras, Greece. abakan@upatras.gr
Zboril
Radek
R
Bouropoulos
Nikolaos
N
Kallinteri
Paraskevi
P
Favretto
Marco E
ME
Parker
Terry L
TL
Mullertz
Anette
A
Fatouros
Dimitrios G
DG
D016475:3T3 Cells; D000818:Animals; D003102:Colloids / Q000737:chemistry; D016503:Drug Delivery Systems; D004655:Emulsions / Q000737:chemistry; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D051379:Mice; D036103:Nanotechnology / Q000379:methods*; D012965:Sodium Chloride / Q000737:chemistry; D013696:Temperature; D014961:X-Ray Diffraction
D003102:Colloids; D004655:Emulsions; D008055:Lipids; D012965:Sodium Chloride; D052203:Ferrosoferric Oxide