Acute generalized exanthematous pustulosis induced by itraconazole: an immunological approach.
Acute generalized exanthematous pustulosis (AGEP) is an uncommon disease, which presents as a nonfollicular erythematous sterile pustular eruption. More than 90% of the cases are induced by adverse drug reactions, often triggered by anti-infectious systemic drugs. We report a case of itraconazole-induced AGEP in a 22-year-old man, with an assessment of his cytokine/chemokine production and drug-specific cell reactivity. We found that AGEP, like other T cell-mediated drug eruptions, alters the immunological status of the patient, probably favouring T-cell activation, recruitment and regulation. Few cases of itraconazole-induced AGEP have been described in the literature, and to our knowledge, this is the first report in which the cellular immunological features are assessed.
Cançado
G G L
GG
René Rachou Institute, Laboratory of Cellular and Molecular Immunology, Belo Horizonte, MG, Brazil.
Fujiwara
R T
RT
Freitas
P A
PA
Correa-Oliveira
R
R
Bethony
J M
JM
D056150:Acute Generalized Exanthematous Pustulosis / Q000139:chemically induced / Q000276:immunology*; D000935:Antifungal Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000276:immunology*; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects*; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D013601:T-Lymphocytes / Q000502:physiology; D055815:Young Adult
D000935:Antifungal Agents; D017964:Itraconazole