Awaking stem cells from dormancy: growing old and fighting cancer.
It is generally accepted that a distinguishing property of stem cells (SCs), as compared to their more differentiated progenitors, is that of infrequent division, often referred to as 'quiescence'. As regards hematopoietic stem cells (HSC), their resistance to antiproliferative drugs supports this notion. Maintenance of quiescence is thought to be critical for the preservation of HSCs' function.
Viale
Andrea
A
European Institute of Oncology at the IFOM-IEO Campus, Milan, Italy. andrea.viale@ifom-ieo-campus.it
Pelicci
Pier G
PG
D000375:Aging / Q000473:pathology*; D000818:Animals; D002453:Cell Cycle; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D051379:Mice; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000473:pathology