title: Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy.
abstract: Melanoma patients treated with anti-CTLA-4 have shown a range of anti-tumor responses. In this report, we describe the response of a single patient to anti-CTLA-4, with individual lesions disappearing, others stabilizing, and others progressing. These responses can be viewed as a clear manifestation of cancer immunoediting and its three phases of elimination, equilibrium and escape, with each tumor in this patient being at a discrete stage in the process. The patient's course and associated immunological monitoring and other laboratory data are presented in an immunogram, a way to visualize temporal associations between the multiple clinical and laboratory parameters.
authors.affiliation: Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, New York, NY 10065, USA.
authors.forename: Jianda
authors.initials: J
authors.lastname: Yuan
authors.forename: David B
authors.initials: DB
authors.lastname: Page
authors.forename: Geoffrey Y
authors.initials: GY
authors.lastname: Ku
authors.forename: Yanyun
authors.initials: Y
authors.lastname: Li
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Mu
authors.forename: Charlotte
authors.initials: C
authors.lastname: Ariyan
authors.forename: Humilidad F
authors.initials: HF
authors.lastname: Gallardo
authors.forename: Ruth-Ann
authors.initials: RA
authors.lastname: Roman
authors.forename: Agnes I
authors.initials: AI
authors.lastname: Heine
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Terzulli
authors.forename: Erika
authors.initials: E
authors.lastname: Ritter
authors.forename: Sacha
authors.initials: S
authors.lastname: Gnjatic
authors.forename: Gerd
authors.initials: G
authors.lastname: Ritter
authors.forename: Achim A
authors.initials: AA
authors.lastname: Jungbluth
authors.forename: James P
authors.initials: JP
authors.lastname: Allison
authors.forename: Lloyd J
authors.initials: LJ
authors.lastname: Old
authors.forename: Jedd D
authors.initials: JD
authors.lastname: Wolchok
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002452:Cell Count; D002469:Cell Separation; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D000074324:Ipilimumab; D008214:Lymphocytes / Q000187:drug effects; D008545:Melanoma / Q000188:drug therapy* / Q000276:immunology / Q000556:secondary*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D000074324:Ipilimumab