Mitochondrial ion transport pathways: role in metabolic diseases.
Mitochondria are the central coordinators of energy metabolism and alterations in their function and number have long been associated with metabolic disorders such as obesity, diabetes and hyperlipidemias. Since oxidative phosphorylation requires an electrochemical gradient across the inner mitochondrial membrane, ion channels in this membrane certainly must play an important role in the regulation of energy metabolism. However, in many experimental settings, the relationship between the activity of mitochondrial ion transport and metabolic disorders is still poorly understood. This review briefly summarizes some aspects of mitochondrial H+ transport (promoted by uncoupling proteins, UCPs), Ca2+ and K+ uniporters which may be determinant in metabolic disorders.
Cardoso
Ariel R
AR
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil.
Queliconi
Bruno B
BB
Kowaltowski
Alicia J
AJ
D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D017136:Ion Transport; D008659:Metabolic Diseases / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism; D008954:Models, Biological; D010084:Oxidation-Reduction; D011188:Potassium / Q000378:metabolism; D015221:Potassium Channels / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D000071256:Uncoupling Protein 1
D015220:Calcium Channels; D007473:Ion Channels; D024101:Mitochondrial Proteins; D015221:Potassium Channels; D017382:Reactive Oxygen Species; D000071256:Uncoupling Protein 1; C117780:mitochondrial K(ATP) channel; C034703:mitochondrial calcium uniporter; D011188:Potassium