Impact of intracytoplasmic morphologically selected sperm injection on assisted reproduction outcome: a review.
To date, several publications have focused their attention on a new method for observing spermatozoa called 'motile sperm organelle morphology examination' (MSOME), which enables the evaluation of the fine nuclear morphology of motile spermatozoa in real time at high magnification (>x6000). As a consequence, a new microinjection procedure called intracytoplasmic morphologically selected sperm injection (IMSI) has been developed. The aim of the present work is therefore to evaluate the efficacy of the IMSI technique in the light of the current literature, focusing attention on the potential clinical application of the selection of strictly morphologically normal spermatozoa in patients undergoing conventional intracytoplasmic sperm injection treatments. In addition, a brief analysis of preliminary data regarding the relationship between IMSI and assisted reproduction treatment outcome is presented.
Nadalini
Marco
M
Tecnobios Procreazione, Centre for Reproductive Health, Via Dante 15, I-40125 Bologna, Italy. nadalini@tecnobiosprocreazione.it
Tarozzi
Nicoletta
N
Distratis
Vincenzo
V
Scaravelli
Giulia
G
Borini
Andrea
A
D048430:Cell Shape / Q000502:physiology*; D005260:Female; D006801:Humans; D007246:Infertility; D008297:Male; D008845:Microinjections; D011247:Pregnancy; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D013081:Sperm Motility / Q000502:physiology; D013094:Spermatozoa / Q000166:cytology*; D016896:Treatment Outcome