title: [Role of pendoxifiline (PTX) in different and cute and chronic models of pain in rats].
abstract: Pentoxifilne (PTX) is a non specific inhibitor of cytokines release, which suppress mainly TNF production. The aim of this study was to evaluate behavioural activity changes in response to acute and chronic nociceptive stimulus. PTX was more effective in neuropathic pain than acute pain model. Use of cytokine inhibitors might offer new strategies of drug-resistant chronic pain treatment.
authors.affiliation: Katedra Patofizjologii, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków, Poland. lukaszn@cm-uj.krakow.pl
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Nowak
authors.forename: Daniel
authors.initials: D
authors.lastname: Zurowski
authors.forename: Jarosław
authors.initials: J
authors.lastname: Garlicki
authors.forename: Piotr J
authors.initials: PJ
authors.lastname: Thor
mesh_terms: D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D016207:Cytokines / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000601:surgery; D009619:Nociceptors / Q000187:drug effects / Q000378:metabolism; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology*; D010431:Pentoxifylline / Q000008:administration & dosage* / Q000378:metabolism*; D011292:Premedication; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects
chemical_list: D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D010431:Pentoxifylline