[Amblyogenic factors in patients with an early-onset type of developmental glaucoma].
OBJECTIVE
To extract amblyogenic factors in eyes with an early-onset type of developmental glaucoma despite good post-operative intraocular pressure (IOP) control.


METHODS
Subjects were 24 eyes of 14 patients that underwent successful trabeculotomy by 3 years of age and had their best-corrected visual acuity (BCVA) development monitored for at least 5 years or more after surgery. Principal factor analysis was performed on final logarithmic BCVA, age at operation, corneal diameter, corneal opacity, Haab's striae, spherical equivalent of final refractive error, final astigmatic degree, axial length, preoperative IOP, final vertical cup per disc ratio, and either presence or absence of eccentric fixation. Latent variables that had an eigenvalue of 1 or more underwent an orthogonal rotation with the varimax method in order to yield factor loadings of these 11 parameters.


RESULTS
The parameters that had absolute factor loading values of 0.6 or more in a latent variable including final BCVA were final BCVA, fixation status, refractive error, and Haab's striae. Two-variable comparisons also supported the significant association of the latter three parameters with final BCVA.


CONCLUSIONS
Amblyogenic factors in eyes with an early-onset type of developmental glaucoma were eccentric fixation, myopic refractive error, and the presence of Haab's striae.
Nakamura
Makoto
M
Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan. manakamu@med.kobe-u.ac.jp
Shirabe
Hiroko
H
Mizokami
Kuniyoshi
K
Negi
Akira
A
D000293:Adolescent; D000550:Amblyopia; D002648:Child; D002675:Child, Preschool; D005163:Factor Analysis, Statistical; D005403:Fixation, Ocular; D005500:Follow-Up Studies; D005901:Glaucoma / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009216:Myopia; D014130:Trabeculectomy; D014792:Visual Acuity