title: A nonrandomized comparison of potassium titanyl phosphate and CO2 laser fiber stapedotomy for primary otosclerosis with the otology-neurotology database.
abstract: OBJECTIVE
  To compare short-term hearing results in patients undergoing laser stapedotomy for primary otosclerosis using either the flexible potassium titanyl phosphate (KTP) or CO(2) laser fiber.
  
  
  METHODS
  Prospective nonrandomized clinical study at a tertiary referral center.
  
  
  METHODS
  Two hundred fourteen patients undergoing 214 stapedotomies for otosclerotic stapes fixation were enrolled in this study from January 2008 to January 2010. Comparative analyses were made between a group of 107 patients who underwent stapedotomy with the flexible KTP laser fiber and 107 patients who underwent stapedotomy with the flexible CO(2) laser fiber. Preoperative and postoperative audiometric evaluation at 3 months using conventional audiometry, namely, air-bone gap (ABG), bone-conduction thresholds, and air-conduction thresholds, were assessed.
  
  
  RESULTS
  In the KTP laser group the postoperative ABG was 4.3 dB compared to 3 dB in the CO(2) group, which is a mean difference of 1.3 dB (95% confidence interval [CI], -0.3 to 2.8; P = .10). Of the patients from the KTP group, 92% had a postoperative ABG of 10 dB or less, as compared to 97% in the CO(2) group (mean difference 5%; 95% CI, -10 to 1; P = .14). The postoperative ABG at 4 kHz was 4.9 dB in the KTP and 2.2 dB in the CO(2) group, which is a mean difference of 2.7 dB (95% CI, 0.6-4.7, P = .01). No sensorineural hearing loss was reported.
  
  
  CONCLUSIONS
  The use of the CO(2) laser fiber appears to be associated with slightly better hearing results than the KTP laser fiber, especially when assessed at the 4 kHz frequency.
authors.affiliation: Jean Causse Ear Clinic, Traverse de Béziers, Colombiers, France. robvinc@aol.com
authors.forename: Robert
authors.initials: R
authors.lastname: Vincent
authors.forename: Wilko
authors.initials: W
authors.lastname: Grolman
authors.forename: John
authors.initials: J
authors.lastname: Oates
authors.forename: Neil
authors.initials: N
authors.lastname: Sperling
authors.forename: Maroeska
authors.initials: M
authors.lastname: Rovers
mesh_terms: D000328:Adult; D000368:Aged; D001299:Audiometry; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000295:instrumentation*; D054020:Lasers, Gas; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010040:Otosclerosis / Q000601:surgery*; D010710:Phosphates; D011446:Prospective Studies; D013201:Stapes Surgery / Q000295:instrumentation*; D014025:Titanium; D016896:Treatment Outcome
chemical_list: D010710:Phosphates; C064806:potassium titanylphosphate; D014025:Titanium