title: Mechanical performance and in vivo tests of an acrylic bone cement filled with bioactive sepia officinalis cuttlebone.
abstract: To promote osteointegration, bioactive cuttlebone particles containing collagen were used to fill an acrylic cement, varying filler concentration (0-50 wt%). Cuttlebone was characterized by X-ray diffraction, plasma atomic emission and FT-IR. Mechanical properties of the filled cement were determined following ASTM procedures, included stress-strain, compression, bending, and fracture toughness tests. For in vivo tests, three groups of seven adult healthy rabbits were prepared to make an implant in the parietal bone of each one. For such groups (I-III), the amount of filler in the cement was 0, 10 and 30 wt%, respectively. Mechanical results for the composites complied with norm requirements. However, as mechanical performance for composite with 50 wt% of filler decreased significantly, for the in vivo tests, such composite was excluded. In vivo tests showed that three implants of group I were loosely attached to the parietal bone, whereas all the implants made with cement containing cuttlebone particles (groups II and III) were firmly attached to the parietal bone, indicating osteointegration. These results clearly show the potential of this type of bioactive filler to be used for medical applications.
authors.affiliation: Chemical Engineering Department, University of Guadalajara, Blvd. Gral. Marcelino García Barragán 1451, Guadalajara, Jal. 44430, México.
authors.forename: S
authors.initials: S
authors.lastname: García-Enriquez
authors.forename: H E R
authors.initials: HE
authors.lastname: Guadarrama
authors.forename: I
authors.initials: I
authors.lastname: Reyes-González
authors.forename: E
authors.initials: E
authors.lastname: Mendizábal
authors.forename: C F
authors.initials: CF
authors.lastname: Jasso-Gastinel
authors.forename: B
authors.initials: B
authors.lastname: García-Enriquez
authors.forename: D
authors.initials: D
authors.lastname: Rembao-Bojórquez
authors.forename: C
authors.initials: C
authors.lastname: Pane-Pianese
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry; D019245:Compressive Strength; D055119:Elastic Modulus; D020007:Implants, Experimental; D008422:Materials Testing; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D011817:Rabbits; D049833:Sepia / Q000737:chemistry*; D013718:Tensile Strength
chemical_list: D003094:Collagen; D019904:Polymethyl Methacrylate