Strategies for enhanced drug delivery to the central nervous system.
Treating central nervous system diseases is very challenging because of the presence of a variety of formidable obstacles that impede drug delivery. Physiological barriers like the blood-brain barrier and blood-cerebrospinal fluid barrier as well as various efflux transporter proteins make the entry of drugs into the central nervous system very difficult. The present review provides a brief account of the blood brain barrier, the P-glycoprotein efflux and various strategies for enhancing drug delivery to the central nervous system.
Dwibhashyam
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VS
Pharmacy Practice Department, 4th Floor, Shirdi Sai Baba Cancer Hospital, Manipal-576 104, India.
Nagappa
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AN