Oral mucous membrane pemphigoid in a 6-year-old boy: diagnosis, treatment and 4 years follow-up.
BACKGROUND
Childhood oral pemphigoid is extremely rare and usually takes the form of desquamative gingivitis.


METHODS
We describe a 6-year-old boy who presented with gingival bleeding, pain, eating difficulty, and peeling of the gums. Clinical examination revealed desquamative gingivitis with no extra-oral involvement. The diagnosis was established as oral pemphigoid based on the clinical, histological, and immunofluorescence findings. Symptoms resolved on treatment with occlusive topical corticosteroids. The patient was a carrier of the HLA-DQB(1)*0301 allele.


CONCLUSIONS
Mucous membrane pemphigoid should be considered in the differential diagnosis of chronic desquamative gingivitis in childhood. Occlusive therapy with topical fluocinonide may alleviate the symptoms.
Mostafa
Mostafa I
MI
Human Genetics and Genome Research Division, Department of Oro-dental Genetics. mostafanrc@yahoo.com
Hassib
Nehal F
NF
Nemat
Amany H
AH
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001623:Betamethasone / Q000627:therapeutic use; D002648:Child; D003176:Complement C3 / Q000032:analysis; D003238:Connective Tissue / Q000473:pathology; D003937:Diagnosis, Differential; D004848:Epithelium / Q000473:pathology; D019085:Fluorescent Antibody Technique, Direct; D005500:Follow-Up Studies; D005882:Gingival Diseases / Q000175:diagnosis* / Q000628:therapy; D005891:Gingivitis / Q000175:diagnosis; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D010390:Pemphigoid, Benign Mucous Membrane / Q000175:diagnosis* / Q000628:therapy
D000893:Anti-Inflammatory Agents; D003176:Complement C3; D005938:Glucocorticoids; D007074:Immunoglobulin G; D001623:Betamethasone