title: Drastic effects on fibril formation of amyloid-beta peptides by the addition of amino acid residue units to the termini.
abstract: We report that the addition of amino acids to the amyloid peptide dramatically affected the structure and the rate of formation of amyloid fibrils. The attachment of three lysines to Abeta(10-35) gave the formation of remarkably long fibrils, while three glutamates resulted in a faster formation rate of the fibrils.
authors.affiliation: Laboratory of Biological Chemistry, Department of Chemistry, Faculty of Science, Hokkaido University, N10, W8, Kita-ku, Sapporo 060-0810, Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Asanomi
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sakai
authors.forename: Takuya
authors.initials: T
authors.lastname: Masuda
authors.forename: Xinjiang
authors.initials: X
authors.lastname: Chen
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Chuman
authors.forename: Kohei
authors.initials: K
authors.lastname: Uosaki
authors.forename: Kazuyasu
authors.initials: K
authors.lastname: Sakaguchi
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism; D018625:Microscopy, Atomic Force; D008969:Molecular Sequence Data; D055503:Protein Multimerization; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D016229:Amyloid beta-Peptides