Phomenins and fatty acids from Alternaria infectoria.
Taxa of the Alternaria infectoria species group are the predominant Alternaria spp. found in cereals in Northern Europe. While several pyrones have been isolated from A. infectoria and described as taxonomical markers for species identification, information about the bioactivity of metabolites from the fungus is missing. Bioassay-guided fractionation of rice culture extracts from several strains of A. infectoria linked the observed toxicity of the extracts in MRC-5 cells to free fatty acids, i.e. linoleic acid and alpha-linolenic acid. The fungus also produced a cytotoxic pyrone, which upon isolation and NMR spectroscopic analysis was identified as a mixture of phomenins A and B (approximately 10:1), which have not previously been isolated from an Alternaria species.
Ivanova
Lada
L
National Veterinary Institute, Oslo, Norway.
Petersen
Dirk
D
Uhlig
Silvio
S
D000528:Alternaria / Q000378:metabolism*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D017077:Culture Media, Conditioned / Q000737:chemistry / Q000633:toxicity; D005347:Fibroblasts / Q000187:drug effects; D005506:Food Contamination / Q000032:analysis*; D005516:Food Microbiology; D006801:Humans; D019787:Linoleic Acid / Q000032:analysis / Q000378:metabolism* / Q000633:toxicity; D012275:Oryza / Q000382:microbiology*; D011753:Pyrones / Q000032:analysis / Q000378:metabolism / Q000633:toxicity; D017962:alpha-Linolenic Acid / Q000032:analysis / Q000378:metabolism* / Q000633:toxicity
D017077:Culture Media, Conditioned; D011753:Pyrones; D017962:alpha-Linolenic Acid; D019787:Linoleic Acid