[The preventive effect of 23-valent pneumococcal polysaccharide vaccine against drug-resistant Streptococcus pneumonia in patients with chronic respiratory disease].
OBJECTIVE
To elucidate the preventive effect of 23-valent pneumococcal polysaccharide vaccine (PV) on drug-resistant Streptococcus pneumoniae.


METHODS
Participants (outpatients, over 60 years of age, and with chronic lung disease) were interviewed and divided into two groups: the PV-vaccinated group (n=722) and the non-vaccinated group (n=872). The antimicrobial susceptibility and the genotype of antibiotic-resistant genes among the isolated pneumococcal strains from sputum before and after vaccination were studied.


RESULTS
The number of the isolated strains was as follows: prior to the vaccination, 24 isolates in the vaccinated group, 18 isolates in the non-vaccinated group; after vaccination (within 5 years), 53 isolates in the vaccinated group, 46 isolated in the non-vaccinated group. The PV decreased the frequency of Penicillin G-resistant strains successfully (from 16.7 to 7.5%) in the vaccinated group while the frequency increased (from 5.5 to 15.2%) in the non-vaccinated group during the same period. In genetic analysis, the rates of strains with altered pbpla, pbp2x and pbp2b were decreased in the vaccinated group than the non-vaccinated group (28.6% versus 53.3%).


CONCLUSIONS
The 23-valent pneumococcal polysaccharide vaccine may have a preventive effect against drug-resistant Streptococcus pneumoniae.
Kobayashi
Nobuaki
N
Department of Respiratory Medicine, Yokohama City University Hospital.
Watanuki
Yuji
Y
Miyazawa
Naoki
N
Kudo
Makoto
M
Inoue
Satoshi
S
Sato
Takashi
T
Mishina
Kei
K
Takahashi
Hiroshi
H
Kaneko
Takeshi
T
Ishigatsubo
Yoshiaki
Y
D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000150:complications*; D008297:Male; D022242:Pneumococcal Vaccines / Q000276:immunology*; D011018:Pneumonia, Pneumococcal / Q000235:genetics / Q000517:prevention & control*; D013296:Streptococcus pneumoniae / Q000187:drug effects; D014611:Vaccination
D022242:Pneumococcal Vaccines