title: Cu-catalyzed N-alkynylation of imidazoles, benzimidazoles, indazoles, and pyrazoles using PEG as solvent medium.
abstract: A facile and efficient Cu(I)-catalyzed cross-coupling method is reported for the preparation of N-alkynyl or N-bromoalkenyl heteroarenes from bromoalkynes. Generally superior yields and functional group tolerance were obtained with microwave (MW) irradiation using imidazole, benzimidazole, pyrazole, and indazole substrates and poly(ethylene glycol) 400 (PEG400) as an additive. We speculate that PEG400 acts as both a Cu(I)-stabilizing ligand as well as a phase transfer solvent.
authors.affiliation: Department of Chemistry, University of Leicester, University Road, Leicester LE1 7RH, United Kingdom. gab13@le.ac.uk
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Burley
authors.forename: David L
authors.initials: DL
authors.lastname: Davies
authors.forename: Gerry A
authors.initials: GA
authors.lastname: Griffith
authors.forename: Michael
authors.initials: M
authors.lastname: Lee
authors.forename: Kuldip
authors.initials: K
authors.lastname: Singh