title: Recent approaches for enhancing sensitivity in enantioseparations by CE.
abstract: This article reviews the latest methodological and instrumental improvements for enhancing sensitivity in chiral analysis by CE. The review covers literature from March 2007 until May 2009, that is, the works published after the appearance of the latest review article on the same topic by Sánchez-Hernández et al. [Electrophoresis 2008, 29, 237-251]. Off-line and on-line sample treatment techniques, on-line sample preconcentration strategies based on electrophoretic and chromatographic principles, and alternative detection systems to the widely employed UV/Vis detection in CE are the most relevant approaches discussed for improving sensitivity. Microchip technologies are also included since they can open up great possibilities to achieve sensitive and fast enantiomeric separations.
authors.affiliation: Departamento de Química Analítica, Universidad de Alcalá, Madrid, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Sánchez-Hernández
authors.forename: Carmen
authors.initials: C
authors.lastname: García-Ruiz
authors.forename: María
authors.initials: M
authors.lastname: Luisa Marina
authors.forename: Antonio
authors.initials: A
authors.lastname: Luis Crego
mesh_terms: D005591:Chemical Fractionation / Q000379:methods*; D019075:Electrophoresis, Capillary / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis; D011506:Proteins / Q000032:analysis; D012680:Sensitivity and Specificity; D013237:Stereoisomerism
chemical_list: D004364:Pharmaceutical Preparations; D011506:Proteins