title: Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-L-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT.
abstract: A new phenylboric acid derivative entrapped lipiodol (PBAD-lipiodol) was developed as a boron carrier for the boron neutron capture therapy (BNCT) of hepatoma in Taiwan. The biodistribution of both PBAD-lipiodol and BPA-fructose was assayed in GP7TB hepatoma-bearing rat model. The highest uptake of PBAD-lipiodol was found at 2h post injection. The application of BNCT for the hepatoma treatment in tumor-bearing rats is suggested to be 2-4h post PBAD-lipiodol injection.
authors.affiliation: Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.
authors.forename: A H
authors.initials: AH
authors.lastname: Liao
authors.forename: F I
authors.initials: FI
authors.lastname: Chou
authors.forename: Y C
authors.initials: YC
authors.lastname: Kuo
authors.forename: H W
authors.initials: HW
authors.lastname: Chen
authors.forename: J J
authors.initials: JJ
authors.lastname: Kai
authors.forename: C W
authors.initials: CW
authors.lastname: Chang
authors.forename: F D
authors.initials: FD
authors.lastname: Chen
authors.forename: J J
authors.initials: JJ
authors.lastname: Hwang
mesh_terms: D000818:Animals; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001897:Boronic Acids / Q000138:chemical synthesis / Q000493:pharmacokinetics* / Q000494:pharmacology; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics* / Q000494:pharmacology; D007459:Iodized Oil / Q000138:chemical synthesis / Q000493:pharmacokinetics* / Q000494:pharmacology; D008114:Liver Neoplasms, Experimental / Q000378:metabolism* / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D008297:Male; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000502:physiology; D051381:Rats; D011916:Rats, Inbred F344; D014018:Tissue Distribution
chemical_list: D001897:Boronic Acids; D005462:Fluorine Radioisotopes; D010649:Phenylalanine; D007459:Iodized Oil