title: Sildenafil improves scotoma after posterior cerebral infarctions: a case report.
abstract: A 65-year-old man had an embolic stroke of both posterior cerebral arteries in 2002. Two years later he noted rapid improvement of the residual bilateral inferior quadrant anopia whenever he took 25 mg sildenafil. The improvement of scotomas was verified by visual field examinations and persisted reproducibly for 3-7 days. An overlay of a subtraction of functional magnetic resonance imaging (MRI) during visual stimulation before and after medication onto a T1-weighted MRI of the patient revealed additional activations along the margins of the old cerebral infarctions. These findings and the additional results of a perfusion MRI suggest that phosphodiesterase 5 inhibitors may prove beneficial in the rehabilitative course after ischemic strokes.
authors.forename: Peter
authors.initials: P
authors.lastname: Schlindwein
authors.forename: B M
authors.initials: BM
authors.lastname: Eicke
authors.forename: P
authors.initials: P
authors.lastname: Stoeter
authors.forename: M
authors.initials: M
authors.lastname: Dieterich
mesh_terms: D000368:Aged; D002544:Cerebral Infarction / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines / Q000627:therapeutic use; D012607:Scotoma / Q000188:drug therapy* / Q000209:etiology; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000627:therapeutic use*
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate