Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptor.
Based on structural information for a peptide (P8-2KAQ) that binds to granulocyte-colony stimulating factor receptor (G-CSFR), small ligands with a biaryl scaffold were designed and their binding affinities were evaluated.
El-Haggar
Radwan
R
Department of Biological Science, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.
Kamikawa
Ken
K
Machi
Kazuya
K
Ye
Zhengmao
Z
Ishino
Yuko
Y
Tsumuraya
Takeshi
T
Fujii
Ikuo
I
D015195:Drug Design; D018257:Helix-Loop-Helix Motifs / Q000502:physiology; D008968:Molecular Conformation; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding / Q000502:physiology; D011487:Protein Conformation; D016188:Receptors, Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D013329:Structure-Activity Relationship
D010455:Peptides; D016188:Receptors, Granulocyte Colony-Stimulating Factor