Hyperhemolysis in a patient with beta-thalassemia major.
A case of hyperhemolysis in a 2-year-old boy with beta thalassemia major was noted. After several transfusions, he developed hyperhemolysis with a positive (C3d only) direct antiglobulin test (DAT) and no clinically significant RBC allo- or auto-antibodies. (There was a weak cold antibody, showing a narrow thermal range). Because there was no significant improvement with steroid and immunoglobulin infusions, cyclophosphamide therapy was tried with notable success.
Morawakage
Lakmali R
LR
Perera
B J C
BJ
Dias
P D N
PD
Wijewardana
S K
SK