TGF-beta1-800G>A polymorphism and cerebral infarction in Chinese Han population.
OBJECTIVE
To investigate the association between transforming growth factor beta1(TGF-beta1)-800G>A polymorphism and cerebral infarction (CI).


METHODS
The genotypes of 247 patients with atherosclerotic cerebral infarction and 167 sex- and age-matched healthy controls were detected by PCR-RFLP, and the frequency distribution of alleles calculated.


RESULTS
TGF-beta1-800G>A polymorphism was found in Han population in Hunan Province, China. The distribution of -800G>A genotypes was consistent with Hardy-Weinberg balance in the CI and healthy control group. There was no significant difference between genotypes and allele frequency of TGF-beta1-800G>A in the CI and control group (P>0.05). Logistic regression analysis suggested that no genotypes could increase or reduce the risk of CI onset (P>0.05).


CONCLUSIONS
TGF-beta1-800G>A polymorphism is not associated with CI in Han population in Hunan Province.
Xie
Yiqun
Y
Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zeng
Kaimin
K
Wang
Yining
Y
Xu
Hongwei
H
D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000235:genetics*; D002681:China / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
D053773:Transforming Growth Factor beta1