Liquid-liquid miscibility gaps and hydrate formation in drug-water binary systems: pressure-temperature phase diagram of lidocaine and pressure-temperature-composition phase diagram of the lidocaine-water system.
The pressure-temperature (P-T) melting curve of lidocaine was determined (dP/dT = 3.56 MPa K(-1)), and the lidocaine-water system was investigated as a function of temperature and pressure. The lidocaine-water system exhibits a monotectic equilibrium at 321 K (ordinary pressure) whose temperature increases as the pressure increases until the two liquids become miscible. A hydrate, unstable at ordinary pressure, was shown to form, on increasing the pressure, from about 70 MPa at low temperatures (200-300 K). The thermodynamic conditions of its stability were inferred from the location of the three-phase equilibria involving the hydrate in the lidocaine-water pressure-temperature-mole fraction (P-T-x) diagram.
Ceolin
René
R
Grup de Caracterizació de Materials, Department de Física i Enginyeria Nuclear, ETSEIB, Universitat Politècnica de Catalunya, Diagonal 647, 08028 Barcelona, Catalunya, Spain.
Barrio
Maria
M
Tamarit
Josep-Lluis
JL
Veglio
Nestor
N
Perrin
Marc-Antoine
MA
Espeau
Philippe
P
D004304:Dosage Forms; D006878:Hydroxides; D008012:Lidocaine; D010087:Oxides; D011312:Pressure; D013696:Temperature; D013816:Thermodynamics; D014867:Water / Q000737:chemistry*
D004304:Dosage Forms; D006878:Hydroxides; D010087:Oxides; D014867:Water; D008012:Lidocaine