title: Association between serum vaspin concentrations and visceral adipose tissue in Korean subjects.
abstract: Adipokines modulate multiple signaling pathways of insulin resistance via endocrine, paracrine, or autocrine mechanisms. Visceral adipose tissue (VAT)-derived serpin (vaspin) is a novel adipokine with potential insulin-sensitizing effects. We investigated the association between serum vaspin concentrations and abdominal adiposity. We recruited subjects (N = 150) aged 20 to 69 years who visited our hospital for regular health examinations. Abdominal VAT and subcutaneous adipose tissue areas were assessed by computed tomography. We measured serum vaspin concentrations by enzyme-linked immunosorbent assay. Statistical analysis was performed after stratification, using a homeostasis model for insulin resistance (HOMA-IR). Serum vaspin concentrations correlated positively with age (r = 0.196) when data from all subjects were analyzed. In the higher-HOMA-IR group, serum vaspin levels correlated more prominently with age (r = .344) and VAT area (r = .327) although these associations were not found in the lower-HOMA-IR group. In multivariate linear regression analysis, the VAT area was independently correlated with serum vaspin concentrations in the higher-HOMA-IR group. The association between serum vaspin concentrations and VAT differs according to insulin resistance. Insulin resistance might influence the correlation between serum vaspin concentration and VAT in human subjects.
authors.affiliation: Department of Family Medicine, University of Ulsan College of Medicine, Songpa-gu, Seoul, Korea.
authors.forename: Hye Mi
authors.initials: HM
authors.lastname: Chang
authors.forename: Hye Soon
authors.initials: HS
authors.lastname: Park
authors.forename: Cheol-Young
authors.initials: CY
authors.lastname: Park
authors.forename: Young Sook
authors.initials: YS
authors.lastname: Song
authors.forename: Yeon Jin
authors.initials: YJ
authors.lastname: Jang
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011859:Radiography; D056910:Republic of Korea; D015843:Serpins / Q000097:blood*; D050151:Subcutaneous Fat / Q000000981:diagnostic imaging / Q000378:metabolism; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D007328:Insulin; C507339:SERPINA12 protein, human; D015843:Serpins