title: Metalloproteinases and their regulators in colorectal cancer.
abstract: Metalloproteinases (MPs) such as the matrix metalloproteinases (MMPs) and adamalysins (ADAMs and ADAMTS) are expressed in various stages of colorectal cancer (CRC), and some correlate with survival and prognosis. The MPs are regulated by various factors including EMMPRIN, TIMPs, and RECK. In addition, micro-RNAs are found to be relevant for both MP expression levels and CRC prognostication. Both MPs and their regulators could be potential targets for intervention and therapy in CRC.
authors.affiliation: Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
authors.forename: Michel F P
authors.initials: MF
authors.lastname: van der Jagt
authors.forename: Theo
authors.initials: T
authors.lastname: Wobbes
authors.forename: Luc J A
authors.initials: LJ
authors.lastname: Strobbe
authors.forename: Fred C G J
authors.initials: FC
authors.lastname: Sweep
authors.forename: Paul N
authors.initials: PN
authors.lastname: Span
mesh_terms: D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000209:etiology; D004789:Enzyme Activation; D058851:GPI-Linked Proteins; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology; D008666:Metalloendopeptidases / Q000502:physiology; D045726:Metalloproteases / Q000235:genetics / Q000502:physiology*; D035683:MicroRNAs / Q000502:physiology; D019714:Tissue Inhibitor of Metalloproteinases / Q000502:physiology
chemical_list: D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; D035683:MicroRNAs; C115460:RECK protein, human; D019714:Tissue Inhibitor of Metalloproteinases; D045726:Metalloproteases; D008666:Metalloendopeptidases; C028220:Crotalus adamanteus proteinase II