title: Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia.
abstract: A magnetic resonance imaging cardiac magnetic susceptometry (MRI-CS) technique for assessing cardiac tissue iron concentration based on phase mapping was developed. Normal control subjects (n=9) and thalassemia patients (n=13) receiving long-term blood transfusion therapy underwent MRI-CS and MRI measurements of the cardiac relaxation rate R2*. Using MRI-CS, subepicardium and subendocardium iron concentrations were quantified exploiting the hemosiderin/ferritin iron specific magnetic susceptibility. The average of subepicardium and subendocardium iron concentrations and R2* of the septum were found to be strongly correlated (r=0.96, P<.0001), and linear regression analysis yielded CIC (microg Fe/g(wet tissue))=(6.4+/-0.4).R2* (septum) (s(-1)) - (120+/-40). The results demonstrated that septal R2* indeed measures cardiac iron level.
authors.affiliation: Texas Children's Hospital, Houston, TX 77030, USA. jerry.wang@childrens.com
authors.forename: Zhiyue J
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Roland
authors.initials: R
authors.lastname: Fischer
authors.forename: Zili
authors.initials: Z
authors.lastname: Chu
authors.forename: Donald H
authors.initials: DH
authors.lastname: Mahoney
authors.forename: Brigitta U
authors.initials: BU
authors.lastname: Mueller
authors.forename: Raja
authors.initials: R
authors.lastname: Muthupillai
authors.forename: Ellen B
authors.initials: EB
authors.lastname: James
authors.forename: Rajesh
authors.initials: R
authors.lastname: Krishnamurthy
authors.forename: Taylor
authors.initials: T
authors.lastname: Chung
authors.forename: Eric
authors.initials: E
authors.lastname: Padua
authors.forename: Elliott
authors.initials: E
authors.lastname: Vichinsky
authors.forename: Paul
authors.initials: P
authors.lastname: Harmatz
mesh_terms: D000328:Adult; D000465:Algorithms; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007501:Iron / Q000032:analysis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013789:Thalassemia / Q000175:diagnosis* / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007501:Iron