Hydroxylated sclerosporin derivatives from the marine-derived fungus Cadophora malorum.
The marine-derived fungus Cadophora malorum was isolated from the green alga Enteromorpha sp. Growth on a biomalt medium supplemented with sea salt yielded an extract, from which we have isolated sclerosporin and four new hydroxylated sclerosporin derivatives, namely, 15-hydroxysclerosporin (2), 12-hydroxysclerosporin (3), 11-hydroxysclerosporin (4), and 8-hydroxysclerosporin (5). The compounds were evaluated in various biological activity assays. Compound 5 showed a weak fat-accumulation inhibitory activity against 3T3-L1 murine adipocytes.
Almeida
Celso
C
Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
Eguereva
Ekaterina
E
Kehraus
Stefan
S
Siering
Carsten
C
König
Gabriele M
GM
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001410:Bacillus megaterium / Q000187:drug effects; D002708:Chlorella / Q000187:drug effects; D000460:Chlorophyta / Q000382:microbiology; D004926:Escherichia coli / Q000187:drug effects; D055325:Eurotium / Q000187:drug effects; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000935:Antifungal Agents; D012717:Sesquiterpenes