Ceftiofur resistance in Salmonella enterica serovar Heidelberg from chicken meat and humans, Canada.
The Canadian Integrated Program for Antimicrobial Resistance Surveillance describes a strong correlation (r = 0.9, p<0.0001) between ceftiofur-resistant Salmonella enterica serovar Heidelberg isolated from retail chicken and incidence of ceftiofur-resistant Salmonella serovar Heidelberg infections in humans across Canada. In Quebec, changes of ceftiofur resistance in chicken Salmonella Heidelberg and Escherichia coli isolates appear related to changing levels of ceftiofur use in hatcheries during the study period, from highest to lowest levels before and after a voluntary withdrawal, to increasing levels after reintroduction of use (62% to 7% to 20%, and 34% to 6% to 19%, respectively). These events provide evidence that ceftiofur use in chickens results in extended-spectrum cephalosporin resistance in bacteria from chicken and humans. To ensure the continued effectiveness of extended-spectrum cephalosporins for treating serious infections in humans, multidisciplinary efforts are needed to scrutinize and, where appropriate, limit use of ceftiofur in chicken production in Canada.
Dutil
Lucie
L
Public Health Agency of Canada, Saint-Hyacinthe, Quebec, Canada. lucie_dutil@phac-aspc.gc.ca
Irwin
Rebecca
R
Finley
Rita
R
Ng
Lai King
LK
Avery
Brent
B
Boerlin
Patrick
P
Bourgault
Anne Marie
AM
Cole
Linda
L
Daignault
Danielle
D
Desruisseau
Andrea
A
Demczuk
Walter
W
Hoang
Linda
L
Horsman
Greg B
GB
Ismail
Johanne
J
Jamieson
Frances
F
Maki
Anne
A
Pacagnella
Ana
A
Pillai
Dylan R
DR
D000818:Animals; D000900:Anti-Bacterial Agents; D002170:Canada / Q000453:epidemiology; D002511:Cephalosporins / Q000494:pharmacology*; D002645:Chickens / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D008460:Meat / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D011201:Poultry Diseases / Q000188:drug therapy / Q000453:epidemiology; D011792:Quebec / Q000453:epidemiology; D012478:Salmonella Food Poisoning / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D012481:Salmonella Infections, Animal / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D019779:Salmonella enterica / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C053503:ceftiofur