title: Immunohistochemistry of DNA mismatch repair enzyme MSH2 is not correlated with prognostic data from endometrial carcinomas.
abstract: BACKGROUND
  The human Mut-S-homolog-2 (MSH2) is part of the DNA mismatch repair system (MMR). Mutations in genes of the MMR are a predisposition to hereditary non-polyposis colorectal cancer (HNPCC). In women, MMR gene mutations may lead to primary endometrial cancer (EC). The important function of the MMR for the integrity of the DNA during replication makes it probable that the MMR might also be involved in the development and the course of sporadic carcinomas. Insufficient MMR activity or expression levels could be prognostic markers of the disease.
  
  
  METHODS
  Immunohistochemical analysis of MSH2 was performed in 86 tumor samples from patients with EC.
  
  
  RESULTS
  Compared to known tumor markers, namely estrogen and progesterone receptors, histopathological grading, TNM stage and FIGO classification, no significant correlation between MSH2 immunoreactivity and EC was found.
  
  
  CONCLUSIONS
  MSH2 immunohistochemical analysis is not of prognostic value for endometrial carcinoma.
authors.affiliation: Department of Gynecology and Obstetrics, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Schröer
authors.forename: Frank
authors.initials: F
authors.lastname: Köster
authors.forename: Dorothea
authors.initials: D
authors.lastname: Fischer
authors.forename: Ralph Martin
authors.initials: RM
authors.lastname: Dubitscher
authors.forename: Astrid
authors.initials: A
authors.lastname: Woll-Hermann
authors.forename: Klaus
authors.initials: K
authors.lastname: Diedrich
authors.forename: Michael
authors.initials: M
authors.lastname: Friedrich
authors.forename: Darius
authors.initials: D
authors.lastname: Salehin
mesh_terms: D017209:Apoptosis / Q000502:physiology; D053843:DNA Mismatch Repair; D016889:Endometrial Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis; D051718:MutS Homolog 2 Protein / Q000096:biosynthesis*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
chemical_list: D019394:Ki-67 Antigen; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein