[Relationship between the level of MCP-1 expression in sera of RA patients and ILD].
OBJECTIVE
To investigate the function and clinical significance of monocyte chemoattractant protein-1 MCP-1 in the pathogenesis of rheumatoid arthritis(RA)and the relation ship between the expression of MCP-1 in serum and interstitial lung disease (ILD) secondary from RA.


METHODS
60 patients with RA were divided into two groups: 30 cases with simple RA group and 30 cases with ILD secondary from RA (RA+ILD group). The control group incuided 20 healthy cases. Enzyme linked immunosorbent assay (ELISA ) was used to determine the serum expression of MCP-1 in patients healthy controls. The differences of MCP-1 level and other laboratory indexes (IgG, IgA, IgM, alpha2-G, gamma-G, RF, ESR, CRP, and the number of arthrocele) in different groups were compared with software spss13.0.


RESULTS
The expression of MCP-1 in simple RA patients was significantly higher than that in the control group (P>0.05) and significantly lower than that in the RA+ILD group (P>0.01). The level of MCP-1 in serum of RA patieuts was positively correlated with IgG, IgM, and gamma-G.


CONCLUSIONS
MCP-1 plays an important role in the pathogenesis of RA and may contribute to the promotion of lung fibrosis in ILD secondary from RA.
Ling
Tao
T
Department of Rheumatology and Immunology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China. lintao_0825@126.com
Lv
Hao-Zhe
HZ
Ma
Yu-Xia
YX
Shang
Qing-Hui
QH
Zhang
Jin-Tao
JT
Lu
Jing
J
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000150:complications*; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood*; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000097:blood* / Q000209:etiology; D008297:Male; D008875:Middle Aged
D018932:Chemokine CCL2