Involvement of substance P and the neurokinin-1 receptor in radiation-induced hair loss in mice.
We investigated the involvement of substance P (SP) and the neurokinin-1 receptor (NK(1)R) in the development of radiation-induced hair loss in mice. A dose of 40 Gy of gamma irradiation induced hair loss from the 10th to at least the 60th day after irradiation. A specific NK(1)R antagonist, CP-99,994, significantly delayed radiation-induced hair loss and reduced its severity. Furthermore, gamma irradiation induced the expression of preprotachykinin-A, a precursor protein of SP, mRNA in irradiated murine skin on the 10th and 30th days after irradiation. These results indicated that gamma irradiation-induced hair loss was mediated by SP via NK(1)R.
Yamamoto
Kouichi
K
Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Japan. kouichi@sahs.med.osaka-u.ac.jp
Kureyama
Naoko
N
Asano
Keiko
K
Ikeda
Toshiji
T
Yamatodani
Atsushi
A
D000505:Alopecia / Q000188:drug therapy / Q000378:metabolism*; D000818:Animals; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines / Q000494:pharmacology / Q000627:therapeutic use; D011498:Protein Precursors / Q000096:biosynthesis / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000378:metabolism*; D018040:Receptors, Neurokinin-1 / Q000502:physiology* / Q000528:radiation effects; D013373:Substance P / Q000502:physiology* / Q000528:radiation effects; D015320:Tachykinins / Q000096:biosynthesis / Q000528:radiation effects
D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines; D011498:Protein Precursors; D018040:Receptors, Neurokinin-1; D015320:Tachykinins; C044206:preprotachykinin; C080755:3-(2-methoxybenzylamino)-2-phenylpiperidine; D013373:Substance P