title: No association between the GSTP1 exon 5 polymorphism and susceptibility to advanced stage endometriosis in the Korean population.
abstract: OBJECTIVE
  To investigate whether the glutathione-S-transferase P1 (GSTP1) exon 5 polymorphism is associated with susceptibility to advanced stage endometriosis in Korean women.
  
  
  METHODS
  Case-control study in a collective of 260 patients and 164 controls. Genotyping of the GSTP1 exon 5 polymorphism was performed by using real-time TaqMan PCR assay.
  
  
  RESULTS
  The genotype distribution of the GSTP1 exon 5 polymorphism in the endometriosis group was not significantly different from that of the control group (AA/AG/GG rates were 64.2%/32.7%/3.1% and 65.2%/31.7%/3.0% for the endometriosis and control groups, respectively, P = 0.977). Further subgroup analysis according to either stage or bilaterality of ovarian endometrioma also found no significant difference in the genotype distribution between any of the endometriosis subgroups and the control group.
  
  
  CONCLUSIONS
  These findings suggest that the GSTP1 exon 5 polymorphism is not a major determinant of the development of advanced stage endometriosis in the Korean population.
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yungun-dong, Chongno-ku, Seoul, South Korea.
authors.forename: Myung Jae
authors.initials: MJ
authors.lastname: Jeon
authors.forename: Young Min
authors.initials: YM
authors.lastname: Choi
authors.forename: Min A
authors.initials: MA
authors.lastname: Hong
authors.forename: Gyoung Hoon
authors.initials: GH
authors.lastname: Lee
authors.forename: Seung Yup
authors.initials: SY
authors.lastname: Ku
authors.forename: Seok Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Jung Gu
authors.initials: JG
authors.lastname: Kim
authors.forename: Shin Yong
authors.initials: SY
authors.lastname: Moon
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D004715:Endometriosis / Q000235:genetics*; D005091:Exons / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D007723:Korea; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA
chemical_list: C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi