Ingenuity pathway analysis of clozapine-induced obesity.
BACKGROUND
Lipid accretion is one of the major side effects of clozapine pharmacotherapy of schizophrenia that made clozapine into an interesting obesity drug model.


METHODS
Ingenuity Pathway Analysis (IPA) engine was used for core analysis and building the networks of weight regulation.


RESULTS
The examination of molecules that were selected into 'clozapine neighborhood' identified them as multifunctional signals that appear to orchestrate vascular and tissue functions plausibly implicated in adiposity side effect.


CONCLUSIONS
It is hypothesized that clozapine unmasks the functional and morphological phenotype of microvascular deficit that facilitates shunting nutrients from utilization toward storage.
Myslobodsky
Michael
M
Howard University Graduate School, Washington, DC, USA. myslobom@mail.nih.gov
D000273:Adipose Tissue / Q000187:drug effects / Q000502:physiology; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003024:Clozapine / Q000009:adverse effects*; D006801:Humans; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D008954:Models, Biological; D018377:Neurotransmitter Agents / Q000502:physiology; D009765:Obesity / Q000139:chemically induced*; D012559:Schizophrenia / Q000188:drug therapy*
D014150:Antipsychotic Agents; D018377:Neurotransmitter Agents; D003024:Clozapine