title: Successful combination therapy for severe infantile hemangiomas: case report and literature search.
abstract: Infantile hemangiomas are common benign vascular tumors of infancy. Although the majority of uncomplicated hemangiomas involute spontaneously, rapid-growth lesions with complications need early active intervention. On the other hand, severe and complicated lesions can be difficult to treat. Recently, we successfully treated two cases of giant severe infantile facial hemangiomas using local application of bleomycin and pulsed dye laser along with systemic application of dexamethasone. Our results suggest that the multiple modalities of bleomycin, laser, and corticosteroid are a safe and effective approach for early therapeutic intervention of severe facial hemangiomas.
authors.affiliation: Laser Plastic and Aesthetic Center, Liuhuaqiao Hospital, Guangzhou, PR China. ykaihua@163.com
authors.forename: Kai-Hua
authors.initials: KH
authors.lastname: Yuan
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
authors.forename: Wen-Lin
authors.initials: WL
authors.lastname: Yu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Huang
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006258:Head and Neck Neoplasms / Q000151:congenital* / Q000628:therapy*; D006391:Hemangioma / Q000151:congenital* / Q000628:therapy*; D006801:Humans; D007223:Infant; D007459:Iodized Oil / Q000627:therapeutic use; D053685:Laser Therapy / Q000379:methods*; D014221:Triamcinolone / Q000627:therapeutic use
chemical_list: D000903:Antibiotics, Antineoplastic; D005938:Glucocorticoids; D001761:Bleomycin; D014221:Triamcinolone; D003907:Dexamethasone; D007459:Iodized Oil