[Comparison of the action of isolichenin and methanol extract of saffron on long-term potentiation in hippocampal dentate gyrus in vivo].
Long-term potentiation (LTP) is thought as a generative mechanism underlying learning and memory via storing information in central nervous system. Electro-neurophysiological assay for LTP is generally used in screening the drugs that can facilitate learning and memory. By using in vivo LTP technique, isolichenin was found to facilitate LTP induction by a tetanic stimulation (20 pulses/100 Hz) in dentate gyrus. This tetanic stimulation by itself, however, cannot induce LTP. Previous study showed the reagent being able to facilitate LTP-induction, like methanol extract of saffron (MES), usually can antagonize the inhibiting effect of 30% ethanol on LTP induction (30 pulses/60 Hz). Isolichenin may also fall into such kind of drugs. Interestingly, comparatively study showed that isolichenin failed to antagonize the inhibiting effect of 30% ethanol on LTP induction (30 pulses/60 Hz). This result indicates a different unknown mechanism existing in the effect of isolichenin on LTP or memory formation.
He
Wen-Bin
WB
Shanxi College of Traditional Chinese Medicine, Taiyuan 030024, China.
Zhang
Jun-Long
JL
Xue
Wei
W
Hu
Jin-Feng
JF
Wu
Dong-Hui
DH
Chen
Nai-Hong
NH
D000818:Animals; D027622:Crocus / Q000737:chemistry*; D018891:Dentate Gyrus / Q000187:drug effects* / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D011134:Polysaccharides; C001477:isolichenin