Animal models of myocardial and vascular injury.
Over the past century, numerous animal models have been developed in an attempt to understand myocardial and vascular injury. However, the successful translation of results observed in animals to human therapy remains low. To understand this problem, we present several animal models of cardiac and vascular injury that are of particular relevance to the cardiac or vascular surgeon. We also explore the potential clinical implications and limitations of each model with respect to the human disease state. Our results underscore the concept that animal research requires an in-depth understanding of the model, animal physiology, and the potential confounding factors. Future outcome analyses with standardized animal models may improve translation of animal research from the bench to the bedside.
Abarbanell
Aaron M
AM
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Herrmann
Jeremy L
JL
Weil
Brent R
BR
Wang
Yue
Y
Tan
Jiangning
J
Moberly
Steven P
SP
Fiege
Jeremy W
JW
Meldrum
Daniel R
DR
D000818:Animals; D030801:Animals, Genetically Modified; D003327:Coronary Disease / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology*; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005121:Extremities / Q000098:blood supply; D006321:Heart / Q000502:physiology* / Q000503:physiopathology; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D015994:Incidence; D007511:Ischemia / Q000503:physiopathology; D051379:Mice; D023421:Models, Animal; D008954:Models, Biological; D009203:Myocardial Infarction / Q000453:epidemiology / Q000503:physiopathology*; D017202:Myocardial Ischemia / Q000503:physiopathology*; D014481:United States / Q000453:epidemiology