Differing expression of metalloprotease and of adhesion molecules in signet-ring cell and intestinal colorectal carcinoma.
BACKGROUND
Pure signet-ring cell colorectal carcinoma (SRCC) is an infrequent and highly malignant histological variant of colorectal cancer (CRC), while it is present as a histological component in colorectal carcinomas more frequently.


METHODS
The aim of this work was to widen the knowledge of the biological factors involved in the pathogenesis and aggressiveness of SRCC by the identification and evaluation of possible molecular abnormalities. By means of immunohistochemistry the expression of the proteolytic degradation enzyme matrix metalloprotease (MMP)-1, that is a collagenase specifically degrading collagens I, II, III and of the adhesion proteins E-cadherin, beta-catenin and fibronectin which are usually involved in the carcinogenesis of conventional colorectal tumours was investigated.


RESULTS
SRCCs showed a significantly greater MMP-1 expression compared to the ordinary intestinal colorectal cancer (ICRC) and a significantly reduced E-cadherin, beta-catenin and fibronectin expression.


CONCLUSIONS
The biological aggressiveness and strong metastatic behaviour of SRCC could be due to high MMP-1 and low expression of the adhesion molecules.
Cabibi
Daniela
D
Dipartimento di Scienze Farmacologiche, Policlinico Via del Vespro, Palermo, Italy.
Calascibetta
Anna
A
Aragona
Federico
F
Martorana
Anna
A
Campione
Maria
M
Sanguedolce
Rosario
R
D000368:Aged; D015820:Cadherins / Q000096:biosynthesis*; D018279:Carcinoma, Signet Ring Cell / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005353:Fibronectins / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis*; D009367:Neoplasm Staging; D051176:beta Catenin / Q000096:biosynthesis*
D015820:Cadherins; D005353:Fibronectins; D051176:beta Catenin; D020781:Matrix Metalloproteinase 1