title: Improvement of sleep-related breathing disorder in patients with end-stage renal disease after kidney transplantation.
abstract: Sleep-related breathing disorder (SRBD) is a common symptom of end-stage renal disease (ESRD). The aim of this study was to determine whether kidney transplantation improves SRBD. Twenty-four patients with ESRD, who were admitted for kidney transplantation, underwent a sleep study using a portable ventilation effort recorder on the night before transplantation. Of these patients, 20 could repeat the overnight monitoring two wk after the transplantation. The median apnea-hypopnea index (AHI) of the 20 patients was 13.5 (range, 2-40), and significantly reduced to 4.5 (range, 0-20) after transplantation (p = 0.003). This reduction was most prominent in 12 patients with SRBD, for whom the median AHI fell from 22 (range, 10-40) to 6.5 (range, 1-20; p = 0.010). SRBD improvement, defined as an AHI equal to or >50% and/or reduced to <10/h, was observed in eight of the 12 apneic patients. These results suggest that kidney transplantation may immediately improve SRBD in patients with ESRD. However, conclusions from this study should be taken with caution because of the limitations of our method, specifically the use of a portable recorder and a small number of patients.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
authors.forename: Jeong Jin
authors.initials: JJ
authors.lastname: Lee
authors.forename: Gaab Soo
authors.initials: GS
authors.lastname: Kim
authors.forename: Jie Ae
authors.initials: JA
authors.lastname: Kim
authors.forename: Sung-Joo
authors.initials: SJ
authors.lastname: Kim
authors.forename: Jin Gu
authors.initials: JG
authors.lastname: Kang
authors.forename: Gunn Hee
authors.initials: GH
authors.lastname: Kim
authors.forename: Hae Hyuk
authors.initials: HH
authors.lastname: Jung
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012119:Respiration; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult