title: Transcription factor, SP1, in epiretinal membranes of patients with proliferative diabetic retinopathy.
abstract: SP1 mRNA was highly expressed in the epiretinal membranes of proliferative diabetic retinopathy (PDR), and the SP1 protein was mainly co-localized with vascular endothelial growth factor. SP1 might play an important role in the angiogenesis of PDR by regulating the promoter activity and expression of genes encoding angiogenesis-related factors.
authors.affiliation: Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Chiba, Japan.
authors.forename: Natsuyo
authors.initials: N
authors.lastname: Yoshida-Hata
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Mitamura
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Oshitari
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Namekata
authors.forename: Chikako
authors.initials: C
authors.lastname: Harada
authors.forename: Takayuki
authors.initials: T
authors.lastname: Harada
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D003930:Diabetic Retinopathy / Q000235:genetics* / Q000378:metabolism; D019773:Epiretinal Membrane / Q000235:genetics / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006801:Humans; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012160:Retina / Q000378:metabolism*; D012171:Retinal Vessels / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016329:Sp1 Transcription Factor / Q000235:genetics* / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D016329:Sp1 Transcription Factor; D042461:Vascular Endothelial Growth Factor A