Secondary fibrosarcoma of the brain stem treated with cyclophosphamide and Imatinib.
Radiation-induced midbrain fibrosarcoma is a rare, highly aggressive tumor, which is associated with poor prognosis. We present the case of a 48-year old man with brainstem fibrosarcoma 20 years following radiation therapy received for a pituitary tumor. We discuss this case in the context of the diagnostic criteria for these tumors, and previous reports of secondary and primary sarcomas of the central nervous system.
Alexandru
Daniela
D
Department of Neurological Surgery, University of California, Irvine, Irvine, CA, USA.
Van Horn
Denise K
DK
Bota
Daniela Annenelie
DA
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D020295:Brain Stem Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005354:Fibrosarcoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D000068877:Imatinib Mesylate; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008636:Mesencephalon / Q000473:pathology; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D009418:S100 Proteins / Q000378:metabolism
D000970:Antineoplastic Agents; D001549:Benzamides; D005904:Glial Fibrillary Acidic Protein; D010879:Piperazines; D011743:Pyrimidines; D009418:S100 Proteins; D000068877:Imatinib Mesylate; D003520:Cyclophosphamide