title: Acyl-coenzyme A binding domain containing 3 (ACBD3; PAP7; GCP60): an emerging signaling molecule.
abstract: Golgi body-mediated signaling has been linked to its fragmentation and regeneration during the mitotic cycle of the cell. During this process, Golgi-resident proteins are released to the cytosol and interact with other signaling molecules to regulate various cellular processes. Acyl-coenzyme A binding domain containing 3 protein (ACBD3) is a Golgi protein involved in several signaling events. ACBD3 protein was previously known as peripheral-type benzodiazepine receptor and cAMP-dependent protein kinase associated protein 7 (PAP7), Golgi complex-associated protein of 60kDa (GCP60), Golgi complex-associated protein 1 (GOCAP1), and Golgi phosphoprotein 1 (GOLPH1). In this review, we present the gene ontology of ACBD3, its relations to other Acyl-coenzyme A binding domain containing (ACBD) proteins, and its biological function in steroidogenesis, apoptosis, neurogenesis, and embryogenesis. We also discuss the role of ACBD3 in asymmetric cell division and cancer. New findings about ACBD3 may help understand this newly characterized signaling molecule and stimulate further research into its role in molecular endocrinology, neurology, and stem cell biology.
authors.affiliation: The Research Institute of the McGill University Health Center and Department of Medicine, McGill University, Montréal, Québec, Canada H3A 1A4. HD37031
authors.forename: Jinjiang
authors.initials: J
authors.lastname: Fan
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Martine
authors.initials: M
authors.lastname: Culty
authors.forename: Vassilios
authors.initials: V
authors.lastname: Papadopoulos
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000032:analysis / Q000145:classification / Q000378:metabolism*; D017209:Apoptosis; D047108:Embryonic Development; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis / Q000145:classification / Q000378:metabolism*; D055495:Neurogenesis; D017434:Protein Structure, Tertiary; D015398:Signal Transduction
chemical_list: C449459:ACBD3 protein, human; D048868:Adaptor Proteins, Signal Transducing; D008565:Membrane Proteins