Severe ifosfamide-induced neurotoxicity: a case report.
BACKGROUND
Ifosfamide is an alkylating agent used in the treatment of several neoplasias. Ifosfamide metabolites accumulation can produce neurotoxicity, which sometimes manifests as a severe clinical picture.


METHODS
We describe the case of a male with a mixed cellularity subtype classical Hodgkin's lymphoma, treated with ifosfamide after other chemotherapy drugs failure. After the first Ifosfamide cycle, the patient showed severe neurological toxicity that resolved 3 weeks later with supportive therapy.


CONCLUSIONS
Among the risk factors described in the literature, our patient had previously received cisplatin chemotherapy, had low albumin serum levels, and had received ifosfamide as a rapid intravenous infusion. The management of the neurotoxicity is symptomatic although some drugs, like methylene blue and albumin, have also been used.


CONCLUSIONS
This case highlights that clinicians should be aware of the possibility of severe neurological toxicity after the administration of ifosfamide and may control the risk factors associated.
Ramos Linares
Sara
S
Pharmacy Department, Hospital Universitario Nuestra Señora de Candelaria, Carretera del Rosario n masculine 145. 38010, Santa Cruz de Tenerife, Spain. sramlin@gobiernodecanarias.org
Breña Atienza
Joaquín
J
Cháfer Rudilla
Matilde
M
Ríos Rull
Pablo
P
Cabello Rodríguez
Ana
A
Merino Alonso
Javier
J
D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects* / Q000627:therapeutic use; D006689:Hodgkin Disease / Q000188:drug therapy; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D020258:Neurotoxicity Syndromes / Q000209:etiology*
D018906:Antineoplastic Agents, Alkylating; D007069:Ifosfamide