title: Interactive effects of metal contamination and pathogenic organisms on the marine bivalve Cerastoderma edule.
abstract: The present study evaluated the interactive effects of cadmium contamination and pathogenic organisms (trematodes Himasthla elongata and bacteria Vibrio tapetis) singularly and in combination during 7 days on the bivalve Cerastoderma edule. Some defense-related activities were analyzed such as genetic expression, metallothionein and immune responses. Trematode metacercarial infection, similar whatever the treatment, induced the strongest responses of immune parameters. Particularly, the interaction between cadmium and parasite exposures induced unusual responses on gene expression and immune responses. No effect of bacterial challenge appeared on bivalve responses, nevertheless a strong mortality of V. tapetis infected cockles occurred between 7 and 14 days. Cadmium bioaccumulation was significantly modulated by both pathogenic organisms. Furthermore, an antagonistic effect of trematodes and bacteria was shown on metal bioaccumulation of co-infected cockles. These results highlighted the importance of considering the multiplicity of perturbation sources in coastal ecosystems to assess the health status of organisms.
authors.affiliation: Université Bordeaux 1, UMR 5805 CNRS, Station Marine d'Arcachon, Place du Dr. Peyneau, Arcachon 33120, France. i.paulpont@epoc.u-bordeaux1.fr
authors.forename: Ika
authors.initials: I
authors.lastname: Paul-Pont
authors.forename: Patrice
authors.initials: P
authors.lastname: Gonzalez
authors.forename: Magalie
authors.initials: M
authors.lastname: Baudrimont
authors.forename: Florence
authors.initials: F
authors.lastname: Jude
authors.forename: Natalie
authors.initials: N
authors.lastname: Raymond
authors.forename: Line
authors.initials: L
authors.lastname: Bourrasseau
authors.forename: Nelly
authors.initials: N
authors.lastname: Le Goïc
authors.forename: Frances
authors.initials: F
authors.lastname: Haynes
authors.forename: Alexia
authors.initials: A
authors.lastname: Legeay
authors.forename: Christine
authors.initials: C
authors.lastname: Paillard
authors.forename: Xavier
authors.initials: X
authors.lastname: de Montaudouin
mesh_terms: D000818:Animals; D049873:Cardiidae / Q000187:drug effects* / Q000382:microbiology*; D005880:Gills / Q000187:drug effects / Q000469:parasitology; D006790:Host-Parasite Interactions; D054884:Host-Pathogen Interactions; D008670:Metals / Q000633:toxicity*; D014200:Trematoda; D014733:Vibrio
chemical_list: D008670:Metals