title: Agrocybe chaxingu polysaccharide prevent inflammation through the inhibition of COX-2 and NO production.
abstract: The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach to the treatment of various diseases, including inflammation and cancer. In this study, we examined the effects of the Agrocybe chaxingu beta-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced nitric oxide (NO) and cyclooxygenase-2 (COX-2) expression in murine macrophage Raw 264.7 cells as well as 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear edema in mice. The polysaccharide significantly inhibited (P 0.01) LPS-induced iNOS and COX-2 expression levels in the cells. Furthermore, topical application of polysaccharide resulted in markedly inhibited (P 0.01) TPA-induced ear edema in mice. These results suggest that this polysaccharide may be used for NO- and COX-2-related disorders such as inflammation and cancer.
authors.affiliation: Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon 200-702, Korea.
authors.forename: Byung Ryong
authors.initials: BR
authors.lastname: Lee
authors.forename: So Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Dae Won
authors.initials: DW
authors.lastname: Kim
authors.forename: Jae Jin
authors.initials: JJ
authors.lastname: An
authors.forename: Ha Yong
authors.initials: HY
authors.lastname: Song
authors.forename: Ki Yeon
authors.initials: KY
authors.lastname: Yoo
authors.forename: Tae Cheon
authors.initials: TC
authors.lastname: Kang
authors.forename: Moo Ho
authors.initials: MH
authors.lastname: Won
authors.forename: Kwang Jae
authors.initials: KJ
authors.lastname: Lee
authors.forename: Kwang Hee
authors.initials: KH
authors.lastname: Kim
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Joo
authors.forename: Hun Ju
authors.initials: HJ
authors.lastname: Ham
authors.forename: Jang Hyun
authors.initials: JH
authors.lastname: Hur
authors.forename: Sung Woo
authors.initials: SW
authors.lastname: Cho
authors.forename: Kyu Hyung
authors.initials: KH
authors.lastname: Han
authors.forename: Kil Soo
authors.initials: KS
authors.lastname: Lee
authors.forename: Jinseu
authors.initials: J
authors.lastname: Park
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Choi
authors.forename: Won Sik
authors.initials: WS
authors.lastname: Eum
mesh_terms: D055362:Agrocybe / Q000737:chemistry*; D000818:Animals; D051546:Cyclooxygenase 2 / Q000096:biosynthesis* / Q000276:immunology; D007249:Inflammation / Q000517:prevention & control*; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000276:immunology; D011134:Polysaccharides / Q000494:pharmacology*
chemical_list: D011134:Polysaccharides; D009569:Nitric Oxide; D051546:Cyclooxygenase 2