Salmonella brain abscess in a patient on chronic azathioprine therapy for myasthenia gravis: report of an unusual case and review of literature in the postantibiotic era.
Focal intracranial infections caused by Salmonella species in adults are exceedingly uncommon. Structural brain injury with coexisting immunocompromised status appears to predispose adults to this rare manifestation of Salmonella infection. We report a case of Salmonella brain abscess in a patient with myasthenia gravis on chronic azathioprine therapy without any prior structural brain lesion. We reviewed world literature and discuss their analysis of Salmonella brain abscess in adult population in the postantibiotic era.
Soni
Chetan R
CR
Mason Eye Institute, Department of Ophthalmology, University of Missouri, Columbia, MO 65212, USA. sonic@health.missouri.edu
Kumar
Gyanendra
G
Bollu
Pradeep C
PC
Sahota
Pradeep
P
Litofsky
N Scott
NS
D000038:Abscess / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000473:pathology; D000890:Anti-Infective Agents / Q000008:administration & dosage; D001379:Azathioprine / Q000008:administration & dosage*; D001921:Brain / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000473:pathology; D002939:Ciprofloxacin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications* / Q000188:drug therapy; D011859:Radiography; D012475:Salmonella / Q000187:drug effects*; D012480:Salmonella Infections / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology
D000890:Anti-Infective Agents; D007166:Immunosuppressive Agents; D008795:Metronidazole; D002939:Ciprofloxacin; D001379:Azathioprine