title: Discovery of anticancer agents of diverse natural origin.
abstract: A collaborative multidisciplinary research project is described in which new natural product anticancer drug leads are obtained from a diverse group of organisms, constituted by tropical plants, aquatic cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which crude extracts of these acquisitions are tested. Progress made in the isolation of lead bioactive secondary metabolites from three tropical plants is discussed.
authors.affiliation: College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn
authors.forename: Esperanza J
authors.initials: EJ
authors.lastname: Carcache de Blanco
authors.forename: Hee-Byung
authors.initials: HB
authors.lastname: Chai
authors.forename: Jimmy
authors.initials: J
authors.lastname: Orjala
authors.forename: Norman R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: D Doel
authors.initials: DD
authors.lastname: Soejarto
authors.forename: Nicholas H
authors.initials: NH
authors.lastname: Oberlies
authors.forename: Mansukh C
authors.initials: MC
authors.lastname: Wani
authors.forename: David J
authors.initials: DJ
authors.lastname: Kroll
authors.forename: Cedric J
authors.initials: CJ
authors.lastname: Pearce
authors.forename: Steven M
authors.initials: SM
authors.lastname: Swanson
authors.forename: Robert A
authors.initials: RA
authors.lastname: Kramer
authors.forename: William C
authors.initials: WC
authors.lastname: Rose
authors.forename: Craig R
authors.initials: CR
authors.lastname: Fairchild
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Vite
authors.forename: Stuart
authors.initials: S
authors.lastname: Emanuel
authors.forename: David
authors.initials: D
authors.lastname: Jarjoura
authors.forename: Frederick O
authors.initials: FO
authors.lastname: Cope