title: 1-Arylsulfonyl-2-(pyridylmethylsulfinyl) benzimidazoles as new proton pump inhibitor prodrugs.
abstract: New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.
authors.affiliation: Department of Physiology, David Geffen School of Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA. jaishin@ucla.edu
authors.forename: Jai Moo
authors.initials: JM
authors.lastname: Shin
authors.forename: George
authors.initials: G
authors.lastname: Sachs
authors.forename: Young-moon
authors.initials: YM
authors.lastname: Cho
authors.forename: Michael
authors.initials: M
authors.lastname: Garst
mesh_terms: D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D001769:Blood; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology*; D054328:Proton Pump Inhibitors / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001562:Benzimidazoles; D011355:Prodrugs; D054328:Proton Pump Inhibitors