title: Translocation of single-stranded DNA through single-walled carbon nanotubes.
abstract: We report the fabrication of devices in which one single-walled carbon nanotube spans a barrier between two fluid reservoirs, enabling direct electrical measurement of ion transport through the tube. A fraction of the tubes pass anomalously high ionic currents. Electrophoretic transport of small single-stranded DNA oligomers through these tubes is marked by large transient increases in ion current and was confirmed by polymerase chain reaction analysis. Each current pulse contains about 10(7) charges, an enormous amplification of the translocated charge. Carbon nanotubes simplify the construction of nanopores, permit new types of electrical measurements, and may open avenues for control of DNA translocation.
authors.affiliation: Department of Chemistry, Columbia University, New York, NY 10027, USA.
authors.forename: Haitao
authors.initials: H
authors.lastname: Liu
authors.forename: Jin
authors.initials: J
authors.lastname: He
authors.forename: Jinyao
authors.initials: J
authors.lastname: Tang
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.forename: Pei
authors.initials: P
authors.lastname: Pang
authors.forename: Di
authors.initials: D
authors.lastname: Cao
authors.forename: Predrag
authors.initials: P
authors.lastname: Krstic
authors.forename: Sony
authors.initials: S
authors.lastname: Joseph
authors.forename: Stuart
authors.initials: S
authors.lastname: Lindsay
authors.forename: Colin
authors.initials: C
authors.lastname: Nuckolls
mesh_terms: D004277:DNA, Single-Stranded; D004553:Electric Conductivity; D004563:Electrochemistry; D017136:Ion Transport; D056004:Molecular Dynamics Simulation; D037742:Nanotubes, Carbon; D009838:Oligodeoxyribonucleotides; D016133:Polymerase Chain Reaction
chemical_list: D004277:DNA, Single-Stranded; D037742:Nanotubes, Carbon; D009838:Oligodeoxyribonucleotides