Poly(ethylene glycol) and hydroxy functionalized alkane phosphate mixed self-assembled monolayers to control nonspecific adsorption of proteins on titanium oxide surfaces.
The spontaneous formation of alkane phosphate self-assembled monolayers (SAMs) on titanium oxide was chosen as a tool to tailor the surface physicochemical properties in terms of nonspecific adsorption of proteins. For this aim, poly(ethylene glycol)-modified (PEG) alkane phosphate was codeposited with OH-terminated alkane phosphates. X-ray photoelectron spectroscopy and ellipsometry of the resulting mixed SAMs indicate that the PEG density can be controlled by varying the mole fraction of PEG-terminated phosphates in the solutions used during the deposition process, leading to surfaces with different degrees of protein resistance.
Bozzini
Sabrina
S
BioMatLab, Bioengineering Department, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy. sabrina.bozzini@polimi.it
Petrini
Paola
P
Tanzi
Maria Cristina
MC
Zürcher
Stefan
S
Tosatti
Samuele
S
D000327:Adsorption; D000473:Alkanes / Q000737:chemistry*; D006801:Humans; D008301:Maleimides / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry*; D056951:Photoelectron Spectroscopy; D011092:Polyethylene Glycols / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D012709:Serum Albumin / Q000737:chemistry; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D000473:Alkanes; D008301:Maleimides; D010710:Phosphates; D011506:Proteins; D012709:Serum Albumin; D014867:Water; C009495:titanium dioxide; C043592:maleimide; D011092:Polyethylene Glycols; D014025:Titanium