Cancer patients with cardiovascular disease have survival rates comparable to cancer patients within the age-cohort of 10 years older without cardiovascular morbidity.
Due to aging of the population the prevalence of both cardiovascular diseases (CVDs) and cancer is increasing. Elderly patients are often under-represented in clinical trials, resulting in limited guidance about treatment and outcome. This study gives insight into the prevalence of CVD among unselected patients with colon, rectum, lung, breast and prostate cancer and its effects on cancer treatment and outcome. Over one fourth (N=11,200) of all included cancer patients aged 50 or older (N=41,126) also suffered from CVD, especially those with lung (34%) or colon cancer (30%). These patients were often treated less aggressively, especially in case COPD or diabetes was also present. CVD had an independent prognostic effect among patients with colon, rectum and prostate cancer. This prognostic effect could not be fully explained by differences in treatment.


CONCLUSIONS
Many cancer patients with severe CVD have a poorer prognosis. More research is needed for explaining the underlying factors for the decreased survival. Such research should lead to treatment guidelines for these patients.
Janssen-Heijnen
Maryska L G
ML
Department of Research, Eindhoven Cancer Registry, Eindhoven, The Netherlands. research@ikz.nl
Szerencsi
Karolina
K
van de Schans
Saskia A M
SA
Maas
Huub A A M
HA
Widdershoven
Jos W
JW
Coebergh
Jan Willem W
JW
D000367:Age Factors; D000368:Aged; D002318:Cardiovascular Diseases / Q000150:complications* / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy*; D015995:Prevalence; D011379:Prognosis; D015996:Survival Rate; D016896:Treatment Outcome