title: Antioxidant and antiviral activities of silybin fatty acid conjugates.
abstract: Two selective acylation methods for silybin esterification with long-chain fatty acids were developed, yielding a series of silybin 7-O- and 23-O-acyl-derivatives of varying acyl chain lengths. These compounds were tested for their antioxidant (inhibition of lipid peroxidation and DPPH-scavenging) and anti-influenza virus activities. The acyl chain length is an important prerequisite for both biological activities, as they improved with increasing length of the acyl moiety.
authors.affiliation: Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídenská 1083, CZ-142 20 Prague, Czech Republic.
authors.forename: Radek
authors.initials: R
authors.lastname: Gazák
authors.forename: Katerina
authors.initials: K
authors.lastname: Purchartová
authors.forename: Petr
authors.initials: P
authors.lastname: Marhol
authors.forename: Lucie
authors.initials: L
authors.lastname: Zivná
authors.forename: Petr
authors.initials: P
authors.lastname: Sedmera
authors.forename: Katerina
authors.initials: K
authors.lastname: Valentová
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kato
authors.forename: Hiroyo
authors.initials: H
authors.lastname: Matsumura
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Kaihatsu
authors.forename: Vladimír
authors.initials: V
authors.lastname: Kren
mesh_terms: D000215:Acylation; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004285:Dogs; D004951:Esterification; D005227:Fatty Acids / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009975:Orthomyxoviridae / Q000187:drug effects*; D000077385:Silybin; D012838:Silymarin / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D000998:Antiviral Agents; D005227:Fatty Acids; D012838:Silymarin; D000077385:Silybin