T cells and dendritic cells in glomerular disease: the new glomerulotubular feedback loop.
A newly described glomerulotubular feedback loop may explain the relationship between glomerular damage, epitope spreading, tubulointerstitial nephritis, proteinuria as a progression factor, and the importance of the local milieu in kidney damage. It also opens the horizons for exciting innovative approaches to therapy of both acute and chronic kidney diseases.
Sung
Sun-Sang
SS
Division of Nephrology, University of Virginia, Charlottesville, Virginia 22908-0133, USA.
Bolton
Warren K
WK
D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D025461:Feedback, Physiological; D006801:Humans; D007674:Kidney Diseases / Q000276:immunology* / Q000473:pathology; D007678:Kidney Glomerulus / Q000276:immunology* / Q000473:pathology; D007684:Kidney Tubules / Q000276:immunology* / Q000473:pathology; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology*