Serum cardiac troponin I is related to increased left ventricular wall thickness, left ventricular dysfunction, and male gender in hypertrophic cardiomyopathy.
BACKGROUND
Serum cardiac troponin I (cTnI) is a sensitive and specific marker of myocardial injury. However, a systematic evaluation of cTnI in hypertrophic cardiomyopathy (HCM) patients has not been performed.


OBJECTIVE
The purpose of this study is to evaluate cTnI and determine its relationship to clinical features in HCM.


METHODS
We studied serum cTnI in 162 consecutive HCM patients.


RESULTS
Serum cTnI ranged from 0.01 to 0.83 ng/mL (mean, 0.068 +/- 0.100 ng/mL) and was higher in male patients (P < .001), those with atrial fibrillation (P = .033), and left ventricular (LV) systolic dysfunction (P = .046). Serum cTnI values were also correlated with maximum LV wall thickness (r = 0.30, P < .001), LV end-systolic diameter (r = 0.20, P = .012), and E/Ea (peak early transmitral filling velocity/early diastolic mitral annulus velocity; r = 0.24, P = .004). Serum cTnI levels were not significantly different among New York Heart Association (NYHA) functional class and there was no difference between patients with or without LV outflow tract obstruction; although B-type natriuretic peptide (BNP) levels showed significant difference in those variables. Serum cTnI had very weak correlation with BNP values (r = 0.18, P = .023). Multivariate analysis revealed an independent relationship between cTnI and maximum LV wall thickness, E/Ea, and male gender.


CONCLUSIONS
In patients with HCM, serum cTnI was associated with important clinical indices such as maximum LV wall thickness, LV dysfunction, and male gender. Serum cTnI seemed to have clinical significance different from that of BNP and may not be reflecting cardiac load but the LV remodeling process in HCM.
Kubo
Toru
T
Department of Medicine and Geriatrics, Kochi Medical School, Kochi, Japan.
Kitaoka
Hiroaki
H
Okawa
Makoto
M
Yamanaka
Shigeo
S
Hirota
Takayoshi
T
Hoshikawa
Eri
E
Hayato
Kayo
K
Yamasaki
Naohito
N
Matsumura
Yoshihisa
Y
Yasuda
Nobufumi
N
Sugiura
Tetsuro
T
Doi
Yoshinori L
YL
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D016009:Chi-Square Distribution; D002648:Child; D003430:Cross-Sectional Studies; D015150:Echocardiography, Doppler; D005260:Female; D006439:Hemodynamics; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012737:Sex Factors; D019210:Troponin I / Q000097:blood*; D015854:Up-Regulation; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling; D055815:Young Adult
D015415:Biomarkers; D019210:Troponin I; D020097:Natriuretic Peptide, Brain