GPCR interacting proteins (GIPs) in the nervous system: Roles in physiology and pathologies.
G protein-coupled receptors (GPCRs) are key transmembrane recognition molecules for regulatory signals such as light, odors, taste hormones, and neurotransmitters. In addition to activating guanine nucleotide binding proteins (G proteins), GPCRs associate with a variety of GPCR-interacting proteins (GIPs). GIPs contain structural interacting domains that allow the formation of large functional complexes involved in G protein-dependent and -independent signaling. At the cellular level, other functions of GIPs include targeting of GPCRs to subcellular compartments and their trafficking to and from the plasma membrane. Recently, roles of GPCR-GIP interactions in central nervous system physiology and pathologies have been revealed. Here, we highlight the role of GIPs in some important neurological and psychiatric disorders, as well as their potential for the future development of therapeutic drugs.
Bockaert
Joël
J
Centre National de la Recherche Scientifique, UMR, Institut de Génomique Fonctionnelle, Montpellier, France. joel.bockaert@igf.cnrs.fr
Perroy
Julie
J
Bécamel
Carine
C
Marin
Philippe
P
Fagni
Laurent
L
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001007:Anxiety / Q000209:etiology; D001921:Brain / Q000502:physiology*; D002352:Carrier Proteins / Q000502:physiology*; D004827:Epilepsy / Q000209:etiology; D005600:Fragile X Syndrome / Q000209:etiology; D000072233:Homer Scaffolding Proteins; D006801:Humans; D019964:Mood Disorders / Q000188:drug therapy; D009473:Neuronal Plasticity; D009687:Nuclear Proteins / Q000502:physiology; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology; D011985:Receptors, Serotonin / Q000502:physiology; D012559:Schizophrenia / Q000209:etiology; D009435:Synaptic Transmission; D011506:Proteins
D000928:Antidepressive Agents; D002352:Carrier Proteins; D000072233:Homer Scaffolding Proteins; D009687:Nuclear Proteins; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; D011985:Receptors, Serotonin; C498297:PICk1 protein, human; C102719:metabotropic glutamate receptor 7; C104077:metabotropic glutamate receptor type 1; C512356:C1QTNF1 protein, human; D011506:Proteins