title: HIV infection and aging independently affect brain function as measured by functional magnetic resonance imaging.
abstract: We investigated the interactions between human immunodeficiency virus (HIV) infection and aging and their effects on brain function demands by means of functional magnetic resonance imaging (fMRI). A multiple-regression model was used to study the association and interaction between fMRI measures, HIV serostatus, and age for 26 HIV-infected subjects and 25 seronegative subjects. Although HIV serostatus and age independently affected fMRI measures, no interaction occurred. Functional brain demands in HIV-positive subjects were equivalent to those of HIV-negative subjects who were 15-20 years older. Frailty parallels between HIV infection and aging could result from continued immunological challenges depleting resources and triggering increased metabolic demands. In the future, fMRI could be a noninvasive biomarker to assess HIV infection in the brain.
authors.affiliation: Department of Neurology, Washington University, St Louis, Missouri, USA. bances@wustl.edu
authors.forename: Beau M
authors.initials: BM
authors.lastname: Ances
authors.forename: Florin
authors.initials: F
authors.lastname: Vaida
authors.forename: Melinda J
authors.initials: MJ
authors.lastname: Yeh
authors.forename: Christine L
authors.initials: CL
authors.lastname: Liang
authors.forename: Richard B
authors.initials: RB
authors.lastname: Buxton
authors.forename: Scott
authors.initials: S
authors.lastname: Letendre
authors.forename: J Allen
authors.initials: JA
authors.lastname: McCutchan
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Ellis
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D005260:Female; D015658:HIV Infections / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D055815:Young Adult