[Predictive factors for histopathological liver injury in the patients who received preoperative systemic chemotherapy for colorectal liver metastases].
The operation for liver metastases from colorectal cancer is increasing due to a progress of chemotherapy. On the other hand, the live damage induced by chemotherapy affects on post operative course. We studied histopathological liver injury on the patients who received preoperative chemotherapy. Between January 2004 and May 2009, forty seven patients underwent hepatectomy for colorectal liver metastases after systemic chemotherapy, and the remnant liver was histopathologically investigated about sinusoidal dilatation and non-alcoholic steatohepatitis. As a result, chemotherapy including irinotecan or oxaliplatin was significantly associated with sinusoidal dilatation, and female gender or higher body mass index was correlated with non-alcoholic steatohepatitis. These results should be taken into consideration before liver resection in patients who have received preoperative chemotherapy.
Kudo
Daisuke
D
Department of Surgery, Hirosaki University School of Medicine.
Tsutsumi
Shinji
S
Akasaka
Harue
H
Jin
Hiroyuki
H
Ohashi
Taisei
T
Muroya
Takahiro
T
Hasebe
Tatsuya
T
Sakamoto
Yoshiyuki
Y
Ishido
Keinosuke
K
Koyama
Motoi
M
Toyoki
Yoshikazu
Y
Murata
Akihiko
A
Narumi
Shunji
S
Kijima
Hiroshi
H
Hakamada
Kenichi
K
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D015179:Colorectal Neoplasms / Q000473:pathology*; D005234:Fatty Liver / Q000139:chemically induced; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged
D000970:Antineoplastic Agents