Worldwide dissemination of the blaOXA-23 carbapenemase gene of Acinetobacter baumannii.
To assess dissemination of OXA-23-producing strains of Acinetobacter baumannii, we obtained 20 carbapenem-resistant, OXA-23-producing isolates from different regions. Their clonal relationship was assessed by pulsed-field gel electrophoresis and multilocus sequence typing. We identified 8 sequence types, including 4 novel types. All except 2 strains belonged to 2 main European clonal lineages. The blaOXA-23 gene was either located on the chromosome or on plasmids and associated with 4 genetic structures.
Mugnier
Pauline D
PD
Institut National de la Sante et de la Recherche Medicale Unite 914, Paris, France.
Poirel
Laurent
L
Naas
Thierry
T
Nordmann
Patrice
P
D000151:Acinetobacter Infections / Q000178:diet therapy / Q000453:epidemiology / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D015139:Blotting, Southern; D003001:Cloning, Molecular; D016521:Electrophoresis, Gel, Pulsed-Field; D022761:Gene Transfer, Horizontal / Q000235:genetics; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics*
C466679:beta-lactamase OXA-23; D001618:beta-Lactamases