title: [A case of advanced gastric cancer treated with S-1 and S-1/paclitaxel showing complete response twice].
abstract: The patient was a 76-year-old man with advanced gastric cancer located in cardia, and was diagnosed to have an invasion to diaphragma and multiple lymph node metastases. We treated successfully with 12-course of S-1 chemotherapy. But second primary gastric cancer was detected in antrum 26 months after primary therapy. We treated with S-1/paclitaxel ( PTX) combined chemotherapy. S-1 (80 mg/m2) was orally administered for 2 weeks followed by a week interval and PTX (50 mg/m2) was also administered days 1 and 8. One course of chemotherapy was 21 days. GIF and abdominal CT revealed complete response (CR) after 3 courses of chemotherapy. We are now going on 6 courses of chemotherapy and the patient did not experience any grade 3 adverse effects.
authors.affiliation: Department of Surgery, Yao Municipal Hospital.
authors.forename: Jin
authors.initials: J
authors.lastname: Matsuyama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Naitou
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hiraki
authors.forename: Shinji
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Shigekazu
authors.initials: S
authors.lastname: Yokoyama
authors.forename: Shunji
authors.initials: S
authors.lastname: Morita
authors.forename: Takashi
authors.initials: T
authors.lastname: Morimoto
authors.forename: Yukio
authors.initials: Y
authors.lastname: Fukushima
authors.forename: Isamu
authors.initials: I
authors.lastname: Nishishou
authors.forename: Takashi
authors.initials: T
authors.lastname: Nomura
authors.forename: Yo
authors.initials: Y
authors.lastname: Sasaki
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002299:Cardia; D004338:Drug Combinations; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D017239:Paclitaxel / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy*; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D017239:Paclitaxel