Cell-targeting and cell-penetrating peptides for delivery of therapeutic and imaging agents.
This review will discuss the basic concepts concerning the use of cell-targeting peptides (CTPs) and cell-penetrating peptides (CPPs) in the context of nanocarrier technology. It deals with the discovery and subsequent evolution of CTPs and CPPs, issues concerning their interactions with cells and their biodistribution in vivo, and their potential advantages and disadvantages as delivery agents. The article also briefly discusses several specific examples of the use of CTPs or CPPs to assist in the delivery of nanoparticles, liposomes, and other nanocarriers.
Juliano
Rudolph L
RL
Department of Pharmacology, University of North Carolina, Chapel Hill, USA. arjay@med.unc.edu
Alam
Rowshon
R
Dixit
Vidula
V
Kang
Hyun Min
HM
D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D050997:Nanomedicine / Q000639:trends; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010455:Peptides / Q000737:chemistry*
D004337:Drug Carriers; D010455:Peptides