title: Studies on Cu(II) ternary complexes involving an aminopenicillin drug and imidazole containing ligands.
abstract: Equilibrium studies on the ternary complex systems involving ampicillin (amp) as ligand (A) and imidazole containing ligands viz., imidazole (Him), benzimidazole (Hbim), histamine (Hist) and histidine (His) as ligands (B) at 37 degrees C and I=0.15 mol dm(-3) (NaClO(4)) show the presence of CuABH, CuAB and CuAB(2). The proton in the CuABH species is attached to ligand A. In the ternary complexes the ligand, amp(A) binds the metal ion via amino nitrogen and carbonyl oxygen atom. The CuAB (B=Hist/His)/CuAB(2) (B=Him/Hbim) species have also been isolated and the analytical data confirmed its formation. Non-electrolytic behavior and monomeric type of chelates have been assessed from their low conductance and magnetic susceptibility values. The electronic and vibrational spectral results were interpreted to find the mode of binding of ligands to metal and geometry of the complexes. This is also supported by the g tensor values calculated from ESR spectra. The thermal behaviour of complexes were studied by TGA/DTA. The redox behavior of the complexes has been studied by cyclic voltammetry. The antimicrobial activity and CT DNA cleavage study of the complexes show higher activity for ternary complexes.
authors.affiliation: Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli 627012, Tamilnadu, India.
authors.forename: Sthanumoorthy
authors.initials: S
authors.lastname: Regupathy
authors.forename: Madhavan Sivasankaran
authors.initials: MS
authors.lastname: Nair
mesh_terms: D000667:Ampicillin / Q000737:chemistry* / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001562:Benzimidazoles / Q000737:chemistry; D003300:Copper / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D004247:DNA / Q000235:genetics / Q000378:metabolism; D053837:DNA Cleavage / Q000187:drug effects; D005670:Fusarium / Q000187:drug effects; D006639:Histidine / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry* / Q000378:metabolism*; D008024:Ligands; D008958:Models, Molecular; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001562:Benzimidazoles; D007093:Imidazoles; D008024:Ligands; D006639:Histidine; D003300:Copper; D000667:Ampicillin; D004247:DNA; C427203:calf thymus DNA; C031000:benzimidazole