title: Two-stage capture employing active transport enables sensitive and fast biosensors.
abstract: Nanoscale sensors enable the detection of analytes with improved signal-to-noise ratio but suffer from mass transport limitations. Molecular shuttles, assembled from, e.g., antibody-functionalized microtubules and kinesin motor proteins, can selectively capture analytes from solution and deliver the analytes to a sensor patch. This two-stage process can accelerate mass transport to nanoscale biosensors and facilitate the rapid detection of analytes. Here, the possible increase of the signal-to-noise ratio is calculated, and the optimal layout of a system which integrates active transport is determined.
authors.affiliation: Department of Materials Science and Engineering, University of Florida, Gainesville, Florida 32611-6400, USA.
authors.forename: Parag
authors.initials: P
authors.lastname: Katira
authors.forename: Henry
authors.initials: H
authors.lastname: Hess
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D004058:Diffusion; D016547:Kinesins / Q000737:chemistry; D008422:Materials Testing; D008870:Microtubules / Q000737:chemistry; D015233:Models, Statistical; D008968:Molecular Conformation; D020409:Molecular Motor Proteins / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods
chemical_list: D020409:Molecular Motor Proteins; D016547:Kinesins