Lipid nanoparticles for drug delivery to the brain: in vivo veritas.
The present article is not aimed at extensively reviewing the literature on lipid nanoparticles, already described in monographs of recent redaction, but will provide a compilation of in vivo evidences supporting their potentiality in overcoming the blood-brain barrier problem. The advantages of using lipid over polymer carriers will be also discussed.
Blasi
Paolo
P
Department of Chemistry and Technology of Drugs, School of Pharmacy, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy.
Schoubben
Aurélie
A
Giovagnoli
Stefano
S
Rossi
Carlo
C
Ricci
Maurizio
M
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics*; D006801:Humans; D008055:Lipids / Q000737:chemistry* / Q000493:pharmacokinetics*; D050997:Nanomedicine / Q000639:trends*
D004337:Drug Carriers; D008055:Lipids