title: Aziridines as intermediates in diversity-oriented syntheses of alkaloids.
abstract: The efficient synthesis of small molecules that collectively comprise optimal small-molecule screening collections is an important goal. With this in mind, we have used N-alkyl aziridines in a regio- and stereochemically controlled synthesis of polycyclic heterocycles based on nucleophilic ring opening and subsequent intramolecular cyclization.
authors.affiliation: Howard Hughes Medical Institute Broad Institute of Harvard and MIT 7 Cambridge Center, Cambridge, MA 02142 stuart_schreiber@harvard.edu.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Taylor
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Schreiber