HemoHIM improves ovarian morphology and decreases expression of nerve growth factor in rats with steroid-induced polycystic ovaries.
Estradiol valerate (EV)-induced polycystic ovaries (PCOs) in rats cause the anovulation and cystic ovarian morphology. We investigated whether treatment with HemoHIM influences the ovarian morphology and the expression of nerve growth factor (NGF) in an EV-induced PCO rat model. PCO was induced by a single intramuscular injection of EV (4 mg, dissolved in sesame oil) in adult cycling rats. HemoHIM was either administered orally (100 mg/kg of body weight/day) for 35 consecutive days or injected intraperitoneally (50 mg/kg of body weight) every other day after EV injection. Ovarian morphology was almost normalized, and NGF was normalized in the PCO + HemoHIM group. HemoHIM lowered the high numbers of antral follicles and increased the number of corpora lutea in PCOs. The results are consistent with a beneficial effect of HemoHIM in the prevention and treatment of PCO syndrome.
Kim
Sung Ho
SH
College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea.
Lee
Hae June
HJ
Kim
Joong Sun
JS
Moon
Changjong
C
Kim
Jong Choon
JC
Bae
Chun Sik
CS
Park
Hae Ran
HR
Jung
Uhee
U
Jo
Sung Kee
SK
D000818:Animals; D004195:Disease Models, Animal; D004958:Estradiol / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D020932:Nerve Growth Factor / Q000235:genetics* / Q000378:metabolism; D010053:Ovary / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D028321:Plant Preparations / Q000008:administration & dosage*; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D028321:Plant Preparations; D004958:Estradiol; D020932:Nerve Growth Factor