title: A history of alcohol dependence increases the incidence and severity of postoperative cognitive dysfunction in cardiac surgical patients.
abstract: Postoperative cognitive dysfunction (POCD) commonly occurs after cardiac surgery. We tested the hypothesis that a history of alcohol dependence is associated with an increased incidence and severity of POCD in male patients undergoing cardiac surgery using cardiopulmonary bypass. Recent verbal and nonverbal memory and executive functions were assessed before and one week after surgery in patients with or without a history of alcohol dependence. Cognitive function was significantly reduced after cardiac surgery in patients with versus without a history of alcohol dependence. The results suggest that a history of alcohol dependence increases the incidence and severity of POCD after cardiac surgery.
authors.affiliation: Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, 53226, USA. judith.hudetz@va.gov
authors.forename: Judith A
authors.initials: JA
authors.lastname: Hudetz
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Patterson
authors.forename: Alison J
authors.initials: AJ
authors.lastname: Byrne
authors.forename: Zafar
authors.initials: Z
authors.lastname: Iqbal
authors.forename: Sweeta D
authors.initials: SD
authors.lastname: Gandhi
authors.forename: David C
authors.initials: DC
authors.lastname: Warltier
authors.forename: Paul S
authors.initials: PS
authors.lastname: Pagel
mesh_terms: D000368:Aged; D000437:Alcoholism / Q000150:complications*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D011446:Prospective Studies; D011594:Psychometrics; D018570:Risk Assessment; D012720:Severity of Illness Index; D013997:Time Factors; D014481:United States / Q000453:epidemiology; D014922:Wisconsin / Q000453:epidemiology