Outsmarting a mastermind.
Moellering et al. recently reported that a cell-permeable "stapled" synthetic peptide of the Notch coactivator Mastermind is a potent dominant-negative inhibitor of oncogenic Notch signaling in T cell acute lymphoblastic leukemia. This new class of inhibitor may find broad utility in blocking protein-protein interactions that underlie many human diseases.
Jones
Katherine A
KA
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-1099, USA. jones@salk.edu
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism* / Q000627:therapeutic use*; D010455:Peptides / Q000627:therapeutic use*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism / Q000628:therapy; D051880:Receptors, Notch / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D004268:DNA-Binding Proteins; C430872:MAML1 protein, human; D009687:Nuclear Proteins; D010455:Peptides; D051880:Receptors, Notch; D014157:Transcription Factors