title: Altered glucose metabolism during chemoradiation for head and neck cancer.
abstract: Platinum-based chemotherapy has been reported to induce diabetes and hyperosmolar coma in nondiabetic patients. The aim of the present study was to determine whether the administration of chemoradiation for head and neck carcinoma alters glucose metabolism during and after treatment.
  
  
  METHODS
  Weekly nonfasting serum glucose level was obtained during treatment of one hundred and six patients with locally advanced head and neck cancer who underwent chemoradiationt.
  
  
  RESULTS
  For the 91 non-diabetic patients, mean serum glucose level measured 97.75 before and 102.1, 102, 104.1, 109.1, 109.7, 110.3, 109.8, 113.2, 107.7 and 104.3 mg/dl during weeks 1-10 of treatment respectively. Serum glucose level elevation reached statistical significance for weeks 5-8.
  
  
  CONCLUSIONS
  Chemoradiation for head and neck cancer may produce severe glucose metabolism alteration during treatment.
authors.affiliation: Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724-5081, USA. NamPhong.Nguyen@yahoo.com
authors.forename: Nam P
authors.initials: NP
authors.lastname: Nguyen
authors.forename: Paul
authors.initials: P
authors.lastname: Vos
authors.forename: Vincent
authors.initials: V
authors.lastname: Vinh-Hung
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Borok
authors.forename: Suresh
authors.initials: S
authors.lastname: Dutta
authors.forename: Ulf
authors.initials: U
authors.lastname: Karlsson
authors.forename: Howard
authors.initials: H
authors.lastname: Lee
authors.forename: Tomas
authors.initials: T
authors.lastname: Martinez
authors.forename: Beng-Hoey
authors.initials: BH
authors.lastname: Jo
authors.forename: Ly M
authors.initials: LM
authors.lastname: Nguyen
authors.forename: Nga
authors.initials: N
authors.lastname: Nguyen
authors.forename: Sabah
authors.initials: S
authors.lastname: Sallah
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D052016:Mucositis / Q000097:blood / Q000139:chemically induced; D011878:Radiotherapy / Q000009:adverse effects; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose; D002945:Cisplatin; D005472:Fluorouracil