title: First Japanese patient treated with parathyroid hormone peptide immunization for refractory hypercalcemia caused by metastatic parathyroid carcinoma.
abstract: Patients with unresectable parathyroid carcinoma develop severe hypercalcemia, bone fractures and renal failure, and become unresponsive to conventional treatments. It has been shown that successful induction of anti-parathyroid hormone (PTH) antibodies, using PTH peptide fragments for immunisation, normalized serum levels of calcium as well as improved clinical symptoms. Here, we report our experience of PTH immunization in a Japanese female suffering from refractory hypercalcemia and renal failure caused by unresectable metastatic parathyroid carcinoma. Upon immunization, there were apparent clinical responses including reduction of serum levels of Ca along with anti-PTH antibodies induction. Therefore, we concluded that PTH immunization was an effective treatment against hypercalcemia caused by metastatic parathyroid carcinomas that are unresponsive to conventional treatments.
authors.affiliation: First Department of Medicine, Nagasaki University School of Medicine, Nagasaki, Japan. ih1504@nagasaki-u.ac.jp
authors.forename: Ichiro
authors.initials: I
authors.lastname: Horie
authors.forename: Takao
authors.initials: T
authors.lastname: Ando
authors.forename: Naoko
authors.initials: N
authors.lastname: Inokuchi
authors.forename: Yumi
authors.initials: Y
authors.lastname: Mihara
authors.forename: Shiro
authors.initials: S
authors.lastname: Miura
authors.forename: Misa
authors.initials: M
authors.lastname: Imaizumi
authors.forename: Toshiro
authors.initials: T
authors.lastname: Usa
authors.forename: Naoe
authors.initials: N
authors.lastname: Kinoshita
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sekine
authors.forename: Shimeru
authors.initials: S
authors.lastname: Kamihara
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood; D002277:Carcinoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006333:Heart Failure; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology / Q000628:therapy*; D007114:Immunization; D016233:Immunotherapy, Active; D009362:Neoplasm Metastasis; D010281:Parathyroid Hormone / Q000097:blood / Q000276:immunology*; D010282:Parathyroid Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D010446:Peptide Fragments / Q000276:immunology; D051437:Renal Insufficiency / Q000209:etiology
chemical_list: D000906:Antibodies; D010281:Parathyroid Hormone; D010446:Peptide Fragments