An examination of anthocyanins' and anthocyanidins' affinity for cannabinoid receptors.
A growing body of evidence suggests that anthocyanins and anthocyanidins may possess analgesic properties in addition to neuroprotective and anti-inflammatory activities. These functionalities suggest a role for the cannabinoid receptor (CB) in mediating biological effects. Competitive radioligand binding assays identified cyanidin (K(i) = 16.2 microM) and delphinidin (K(i) = 21.3 microM) as ligands with moderate affinity to human CB1. For CB2, similar affinities were achieved by cyanidin (K(i) = 33.5 microM), delphinidin (K(i) = 34.3 microM), and peonidin (K(i) = 46.4 microM). Inhibition constants >50 microM were obtained for pelargonidin, malvidin, cyanidin-3,5-di-O-glucoside, cyanidin-3-O-glucoside, cyanidin-3-O-galactoside, and cyanidin-3-O-rutinoside for both CB subtypes.
Korte
Gabriele
G
Department of Psychiatry, University of Regensburg, Regensburg, Germany. gabriele.korte@klinik.uni-regensburg.de
Dreiseitel
Andrea
A
Schreier
Peter
P
Oehme
Anett
A
Locher
Sanja
S
Hajak
Goeran
G
Sand
Philipp G
PG
D000872:Anthocyanins / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D011485:Protein Binding; D043884:Receptor, Cannabinoid, CB1 / Q000737:chemistry*; D043885:Receptor, Cannabinoid, CB2 / Q000737:chemistry*
D000872:Anthocyanins; D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2; C017154:cyanidin; C017185:delphinidin