A1C but not serum glycated albumin is elevated because of iron deficiency in late pregnancy in diabetic women.
OBJECTIVE We have already reported that A1C is elevated because of iron deficiency in late pregnancy among nondiabetic pregnant women. This report examined whether the same phenomenon is observed in pregnant women with diabetes. RESEARCH DESIGN AND METHODS This longitudinal study was conducted in 17 pregnant women with diabetes (20-35 weeks of pregnancy). A1C, serum glycated albumin, erythrocyte indexes, and iron metabolism indexes were measured. RESULTS A1C levels were significantly increased in late pregnancy, whereas serum glycated albumin showed no significant changes. Glycated albumin/A1C ratio, mean corpuscular hemoglobin, serum transferrin saturation, and serum ferritin were significantly decreased in late pregnancy. Serum transferrin saturation showed a significant positive correlation with glycated albumin/A1C ratio. CONCLUSIONS A1C levels, but not serum glycated albumin levels, are elevated in late pregnancy because of iron deficiency in diabetic women. Serum glycated albumin may offer an adequate marker for glycemic control during pregnancy.
Hashimoto
Kunihiko
K
Department of Internal Medicine, Aizenbashi Hospital, Osaka, Japan.
Osugi
Tomoaki
T
Noguchi
Sanai
S
Morimoto
Yasuhiko
Y
Wasada
Kenshi
K
Imai
Shiro
S
Waguri
Masako
M
Toyoda
Rieko
R
Fujita
Tomio
T
Kasayama
Soji
S
Koga
Masafumi
M
D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood* / Q000378:metabolism; D048909:Diabetes Complications / Q000097:blood / Q000378:metabolism; D016640:Diabetes, Gestational / Q000097:blood* / Q000378:metabolism; D004906:Erythrocyte Count; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D017127:Glycation End Products, Advanced; D006801:Humans; D007501:Iron / Q000097:blood / Q000378:metabolism; D008137:Longitudinal Studies; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood* / Q000378:metabolism; D011262:Pregnancy Trimester, Second / Q000097:blood / Q000378:metabolism; D011263:Pregnancy Trimester, Third / Q000097:blood / Q000378:metabolism; D011254:Pregnancy in Diabetics / Q000097:blood* / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism*; D015854:Up-Regulation; D000093423:Glycated Serum Albumin
D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D007501:Iron; D012709:Serum Albumin; D000093423:Glycated Serum Albumin; C517652:hemoglobin A1c protein, human