Hedgehog signalling in colon cancer and stem cells.
The participation of the HH pathway in colon cancer has remained controversial. In this issue, Varnat et al (2009) demonstrate that HH signalling is essential for human colon cancer growth, recurrence, metastases and stem cell expansion. This closeup by Gulino et al discusses the paper and its implications.
Gulino
Alberto
A
Department of Experimental Medicine, Sapienza University, Rome, Italy. alberto.gulino@uniroma1.it
Ferretti
Elisabetta
E
De Smaele
Enrico
E
D003110:Colonic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000166:cytology* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D000071676:Zinc Finger Protein GLI1
C400551:GLI1 protein, human; D053823:Hedgehog Proteins; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1