title: Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma.
abstract: We have used copy number variation (CNV) analysis with SNP mapping arrays for miRNA-15a and miRNA-16-1 expression analysis in patients with multiple myeloma (MM) with or without deletion of chromosome 13q14. MiRNA-15a and miRNA-16 display a range of expression patterns in MM patients, independent of the chromosome 13 status. These findings suggest that genes other than miR-15a and miR-16 may explain the prognostic significance of 13q14 deletions.
authors.affiliation: Department of Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands.
authors.forename: Sophie L
authors.initials: SL
authors.lastname: Corthals
authors.forename: Mojca
authors.initials: M
authors.lastname: Jongen-Lavrencic
authors.forename: Yvonne
authors.initials: Y
authors.lastname: de Knegt
authors.forename: Justine K
authors.initials: JK
authors.lastname: Peeters
authors.forename: H Berna
authors.initials: HB
authors.lastname: Beverloo
authors.forename: Henk M
authors.initials: HM
authors.lastname: Lokhorst
authors.forename: Pieter
authors.initials: P
authors.lastname: Sonneveld
mesh_terms: D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D017353:Gene Deletion; D018628:Gene Dosage; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D035683:MicroRNAs / Q000235:genetics*; D009101:Multiple Myeloma / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: C505362:MIRN16 microRNA, human; D035683:MicroRNAs