title: Deficits in sensory-specific devaluation task performance following genetic deletions of cannabinoid (CB1) receptor.
abstract: Cannabinoid CB1 receptor is abundantly expressed throughout the CNS and is implicated in numerous physiological and behavioral functions, including appetite and feeding. In the present study, wild-type and CB1 heterozygous and homozygous knockout mice were tested on an instrumental outcome-selective devaluation task to assess changes in acquired instrumental response levels for a distinct food reward following selective satiation. Deletion of CB1 receptor, as well as reduction in CB1 expression (HET), produced deficits in outcome-selective instrumental devaluation. These results identify a critical role for CB1 receptor in the ability of animals to represent, update, and/or use sensory-specific outcome representations to alter appetitive behaviors.
authors.affiliation: Neurogenetics and Behavior Center, Department of Psychological & Brain Sciences, The Johns Hopkins University, Baltimore, Maryland 21218, USA. h.crombag@sussex.ac.uk
authors.forename: Hans S
authors.initials: HS
authors.lastname: Crombag
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Johnson
authors.forename: Anne M
authors.initials: AM
authors.lastname: Zimmer
authors.forename: Andreas
authors.initials: A
authors.lastname: Zimmer
authors.forename: Peter C
authors.initials: PC
authors.lastname: Holland
mesh_terms: D000818:Animals; D001070:Appetitive Behavior / Q000502:physiology*; D017353:Gene Deletion; D007858:Learning / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics*; D012677:Sensation / Q000235:genetics; D013647:Task Performance and Analysis
chemical_list: C543264:Cnr1 protein, rat; D043884:Receptor, Cannabinoid, CB1