Assessment of cardiac iron by MRI susceptometry and R2* in patients with thalassemia.
A magnetic resonance imaging cardiac magnetic susceptometry (MRI-CS) technique for assessing cardiac tissue iron concentration based on phase mapping was developed. Normal control subjects (n=9) and thalassemia patients (n=13) receiving long-term blood transfusion therapy underwent MRI-CS and MRI measurements of the cardiac relaxation rate R2*. Using MRI-CS, subepicardium and subendocardium iron concentrations were quantified exploiting the hemosiderin/ferritin iron specific magnetic susceptibility. The average of subepicardium and subendocardium iron concentrations and R2* of the septum were found to be strongly correlated (r=0.96, P<.0001), and linear regression analysis yielded CIC (microg Fe/g(wet tissue))=(6.4+/-0.4).R2* (septum) (s(-1)) - (120+/-40). The results demonstrated that septal R2* indeed measures cardiac iron level.
Wang
Zhiyue J
ZJ
Texas Children's Hospital, Houston, TX 77030, USA. jerry.wang@childrens.com
Fischer
Roland
R
Chu
Zili
Z
Mahoney
Donald H
DH
Mueller
Brigitta U
BU
Muthupillai
Raja
R
James
Ellen B
EB
Krishnamurthy
Rajesh
R
Chung
Taylor
T
Padua
Eric
E
Vichinsky
Elliott
E
Harmatz
Paul
P
D000328:Adult; D000465:Algorithms; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007501:Iron / Q000032:analysis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013789:Thalassemia / Q000175:diagnosis* / Q000378:metabolism*; D055815:Young Adult
D015415:Biomarkers; D007501:Iron