title: Overexpression of Ref-1 Inhibits Lead-induced Endothelial Cell Death via the Upregulation of Catalase.
abstract: The role of apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1) on the lead (Pb)-induced cellular response was investigated in the cultured endothelial cells. Pb caused progressive cellular death in endothelial cells, which occurred in a concentration- and time-dependent manner. However, Ref-1 overexpression with AdRef-1 significantly inhibited Pb-induced cell death in the endothelial cells. Also the overexpression of Ref-1 significantly suppressed Pb-induced superoxide and hydrogen peroxide elevation in the endothelial cells. Pb exposure induced the downregulation of catalase, it was inhibited by the Ref-1 overexpression in the endothelial cells. Taken together, our data suggests that the overexpression of Ref-1 inhibited Pb-induced cell death via the upregulation of catalase in the cultured endothelial cells.
authors.affiliation: Department of Physiology, School of Medicine, Chungnam National University, Daejeon 301-131, Korea.
authors.forename: Kwon Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Sang Ki
authors.initials: SK
authors.lastname: Lee
authors.forename: Hyo Shin
authors.initials: HS
authors.lastname: Kim
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Cho
authors.forename: Hee Kyoung
authors.initials: HK
authors.lastname: Joo
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Lee
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Myoung Soo
authors.initials: MS
authors.lastname: Park
authors.forename: Seok Jong
authors.initials: SJ
authors.lastname: Chang
authors.forename: Chung-Hyun
authors.initials: CH
authors.lastname: Cho
authors.forename: Jin Bong
authors.initials: JB
authors.lastname: Park
authors.forename: Byeong Hwa
authors.initials: BH
authors.lastname: Jeon