First Japanese patient treated with parathyroid hormone peptide immunization for refractory hypercalcemia caused by metastatic parathyroid carcinoma.
Patients with unresectable parathyroid carcinoma develop severe hypercalcemia, bone fractures and renal failure, and become unresponsive to conventional treatments. It has been shown that successful induction of anti-parathyroid hormone (PTH) antibodies, using PTH peptide fragments for immunisation, normalized serum levels of calcium as well as improved clinical symptoms. Here, we report our experience of PTH immunization in a Japanese female suffering from refractory hypercalcemia and renal failure caused by unresectable metastatic parathyroid carcinoma. Upon immunization, there were apparent clinical responses including reduction of serum levels of Ca along with anti-PTH antibodies induction. Therefore, we concluded that PTH immunization was an effective treatment against hypercalcemia caused by metastatic parathyroid carcinomas that are unresponsive to conventional treatments.
Horie
Ichiro
I
First Department of Medicine, Nagasaki University School of Medicine, Nagasaki, Japan. ih1504@nagasaki-u.ac.jp
Ando
Takao
T
Inokuchi
Naoko
N
Mihara
Yumi
Y
Miura
Shiro
S
Imaizumi
Misa
M
Usa
Toshiro
T
Kinoshita
Naoe
N
Sekine
Ichiro
I
Kamihara
Shimeru
S
Eguchi
Katsumi
K
D000328:Adult; D000906:Antibodies / Q000097:blood; D002277:Carcinoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006333:Heart Failure; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology / Q000628:therapy*; D007114:Immunization; D016233:Immunotherapy, Active; D009362:Neoplasm Metastasis; D010281:Parathyroid Hormone / Q000097:blood / Q000276:immunology*; D010282:Parathyroid Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D010446:Peptide Fragments / Q000276:immunology; D051437:Renal Insufficiency / Q000209:etiology
D000906:Antibodies; D010281:Parathyroid Hormone; D010446:Peptide Fragments