Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of daily alcohol drinking on yearly changes in serum total and LDL cholesterol in Japanese men.
Reduced nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit 2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism, is reportedly associated with longevity in the Japanese population. The ND2-237Met genotype may exert resistance to atherogenic diseases, such as myocardial infarction or cerebrovascular disorders. To investigate whether ND2-237 Leu/Met polymorphism is associated with yearly changes in serum lipid levels, we conducted a longitudinal study of 107 healthy Japanese male subjects. Analysis of covariance revealed that the interaction between the ND2-237 Leu/Met genotypes and habitual drinking was significantly associated with yearly changes in serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC) levels (p=0.036 and p=0.006, respectively). In multiple regression analysis, daily drinking was significantly and positively associated with yearly changes in serum LDLC levels in men with ND2-237Met (p=0.026). After adjusting for covariates, yearly changes in serum LDLC levels were significantly lower in non-daily drinkers with ND2-237Met than in those with ND2-237Leu (p=0.047). These results suggest that ND2-237Met has a beneficial impact on yearly changes in serum LDLC in non-daily drinkers but not in daily drinkers.
Makita
Ryuji
R
Department of General Medicine, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
Kokaze
Akatsuki
A
Ohtsu
Tadahiro
T
Ishikawa
Mamoru
M
Matsunaga
Naomi
N
Karita
Kanae
K
Yoshida
Masao
M
Tanaka
Nobukazu
N
Yamamoto
Minoru
M
Hayashi
Junichi
J
Takashima
Yutaka
Y
Kitamoto
Kiyoshi
K
D000328:Adult; D000428:Alcohol Drinking / Q000097:blood / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood / Q000235:genetics; D008078:Cholesterol, LDL / Q000097:blood / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics; D005838:Genotype; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009245:NADH Dehydrogenase / Q000235:genetics*; D011110:Polymorphism, Genetic; D012044:Regression Analysis
D008078:Cholesterol, LDL; D004272:DNA, Mitochondrial; D002784:Cholesterol; D009245:NADH Dehydrogenase; C521326:NADH dehydrogenase subunit 2, human