title: Inflammation and oncogenesis: a vicious connection.
abstract: Epidemiological and experimental data suggest a close connection between inflammation and tumorigenesis. Solid tumors are typically infiltrated with immune cells and inflammation impacts most, if not all, stages of tumorigenesis. Molecular and cellular pathways, which connect inflammation and cancer, have emerged as attractive targets for prevention and therapy. In this review we discuss general mechanisms and concepts of cancer promoting inflammation.
authors.affiliation: Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
authors.forename: Sergei I
authors.initials: SI
authors.lastname: Grivennikov
authors.forename: Michael
authors.initials: M
authors.lastname: Karin
mesh_terms: D003092:Colitis / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000150:complications*; D018836:Inflammation Mediators / Q000276:immunology; D016328:NF-kappa B / Q000378:metabolism; D009369:Neoplasms / Q000151:congenital / Q000276:immunology* / Q000473:pathology; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D018836:Inflammation Mediators; D016328:NF-kappa B; D050796:STAT3 Transcription Factor