gamma-Glutamyltranspeptidase and incident stroke among Japanese men and women: the Circulatory Risk in Communities Study (CIRCS).
OBJECTIVE
Although serum gamma-glutamyltranspeptidase (GGT) levels have been associated with cardiovascular disease incidence, few studies have taken into account the effect of alcohol intake on GGT levels. In this study, we examined the relationship between GGT and stroke incidence according to drinking status.


METHODS
We conducted a prospective cohort study of Japanese women (N=6281) and men (N=3471) aged 40 to 69 years living in communities under systematic surveillance for stroke incidence.


RESULTS
During the 18-year follow-up, 202 (3.2%) women and 230 (6.6%) men had strokes. Serum GGT levels were positively associated with risk of total stroke for women but not men. The multivariable hazard ratios of total stroke for the highest quartile of GGT compared with the lowest quartile were 1.56 (95% CI, 1.01 to 2.39) for women and 1.37 (95% CI, 0.89 to 2.11) for men. Moreover, GGT was associated with total and ischemic stroke risks for never-drinking women.


CONCLUSIONS
Serum GGT is associated with risk of total and ischemic strokes for Japanese women, especially never-drinkers.
Shimizu
Yuji
Y
Public Health, Department of Social and Environmental Medicine, Osaka University, Suita-shi, Osaka, Japan.
Imano
Hironori
H
Ohira
Tetsuya
T
Kitamura
Akihiko
A
Kiyama
Masahiko
M
Okada
Takeo
T
Sato
Shinichi
S
Shimamoto
Takashi
T
Yamagishi
Kazumasa
K
Tanigawa
Takeshi
T
Iso
Hiroyasu
H
D000328:Adult; D000368:Aged; D020268:Alcohol-Induced Disorders, Nervous System / Q000097:blood / Q000201:enzymology / Q000453:epidemiology; D000437:Alcoholism / Q000097:blood / Q000201:enzymology* / Q000453:epidemiology*; D044466:Asian People / Q000235:genetics; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002492:Central Nervous System Depressants / Q000009:adverse effects; D015331:Cohort Studies; D015897:Comorbidity; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D012727:Sex Characteristics; D017678:Sex Distribution; D020521:Stroke / Q000097:blood / Q000201:enzymology* / Q000453:epidemiology*; D005723:gamma-Glutamyltransferase / Q000032:analysis / Q000097:blood*
D015415:Biomarkers; D002492:Central Nervous System Depressants; D000431:Ethanol; D005723:gamma-Glutamyltransferase