Antihyperglycemic activity of naphthylchalcones.
The purpose of the present work was to investigate, following previous works, naphthylchalcones as antihyperglycemic agent in glucose loaded animal model, insulin secretion as well as the action of these compounds on glucose uptake in a target tissue of insulin. The naphthylchalcones were found to have an acute serum glucose-lowering effect in hyperglycemic normal rats. In addition, chalcones 2 and 4 stimulated significantly the insulin secretion induced by glucose. These results suggest that the presence of nitro group and their position in the phenyl rings are responsible for the antihyperglycemic activity of chalcones. Additionally, the effect of chalcones on serum glucose-lowering seems to be a consequence of insulin secretion and these chalcones represent potential compounds with strong antihyperglycemic properties.
Damazio
Rosangela Guollo
RG
Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina Campus Universitário, Bairro Trindade, Cx. Postal 5069, CEP: 88040-970, Florianópolis, Santa Catarina, Brazil.
Zanatta
Ana Paula
AP
Cazarolli
Luisa Helena
LH
Chiaradia
Louise Domeneghini
LD
Mascarello
Alessandra
A
Nunes
Ricardo José
RJ
Yunes
Rosendo Augusto
RA
Barreto Silva
Fátima Regina Mena
FR
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D047188:Chalcones / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D047188:Chalcones; D007004:Hypoglycemic Agents; D007328:Insulin