[Microcalorimetric investigation of two cephalosporins on colon bacteria activity].
The effects of cephradinum and ceftazidime on the metabolism of Escherichia coli (E. coli) DH5alpha was determined by microcalorimetry. The microbial activity was recorded as power-time curves through an ampoule method with a TAM Air Isothermal Microcalorimeter at 37 degrees C. The parameters such as the growth rate constant (k), inhibitory ratio (I), the maximum power output (Pm) and the time (tm) corresponding to the maximum power output were calculated. The results show that the ceftazidime has a better inhibitory effect on E. coli DH5alpha than cephradinum.
Xu
Fen
F
College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China.
Song
Cheng-Gong
CG
Wu
Rui-Hua
RH
Yang
Li-Ni
LN
Sun
Li-Xian
LX
Zhao
Zong-Bao
ZB
Zhang
Zhi-Heng
ZH
Cao
Zhong
Z
Zhang
Ling
L
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002151:Calorimetry / Q000379:methods*; D002442:Ceftazidime / Q000008:administration & dosage / Q000494:pharmacology*; D002515:Cephradine / Q000008:administration & dosage / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D002442:Ceftazidime; D002515:Cephradine