[Evaluation of different combinations of components of Chinese formulation shuangshentongguan by using AUC values].
A sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was applied for the quantification of each component: tetrahydropalmatine (THP), dehydrocorydaline (DHC), salvianolic acid B (SAB), ginsenoside Rg1, Re, Rb1 and Rd in the Chinese herbal component SSTG (Shuangshentongguan) with different combinations. The pharmacokinetic data were analyzed with WinNonlin 5.2 software. The results showed that combination can increase the THP AUC value while the AUC values of SAB, ginsenoside Rg1, Re, Rb1 and Rd were reduced. These results showed significant differences. The AUC value of ginsenoside Rb1 was increased when combined with Danshen or Yanhusuo, but reduced when combined with Danshen and Yanhusuo. The DHC concentration in serum was too low to be determined.
Lin
Li
L
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Liu
Jian-Xun
JX
Zhang
Ying
Y
Duan
Chang-Ling
CL
Lin
Cheng-Ren
CR
Fu
Jian-Hua
JH
D001572:Benzofurans / Q000493:pharmacokinetics*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics; D036145:Ginsenosides / Q000493:pharmacokinetics*; D010618:Phenanthrolines / Q000493:pharmacokinetics; D027561:Salvia miltiorrhiza; D053630:Depsides
D001572:Benzofurans; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D010618:Phenanthrolines; C028972:dan-shen root extract; C442759:ginsenoside Rb1; C076944:salvianolic acid B; D053630:Depsides; C035054:ginsenoside Rg1