Lack of association between schizophrenia and polymorphisms in dopamine metabolism and transport genes.
We investigated the relationship between several functional polymorphisms in genes coding for dopamine metabolism and transport enzymes (MAO-A VNTR; MAO-A 941T>G; DAT VNTR; DAT -67A/T; CYP2D6*3; CYP2D6*4; CYP2D6*5; CYP2D6*6) and the frequency of schizophrenia. Participants in the study were 242 subjects diagnosed with schizophrenia and related disorders and 290 hospital-based controls. Genomic DNA was isolated from whole blood and genotyped by several methods. However, there was no association between schizophrenia and the alleles, genotypes or diplotypes that were studied or their interactions. Polymorphisms in genes coding for dopamine metabolism and transport enzymes did not predispose to or protect from schizophrenia and related disorders.
Alvarez
Santi
S
Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Casanova 143, E-08036 Barcelona, Spain.
Mas
Sergi
S
Gassó
Patricia
P
Bernardo
Miquel
M
Parellada
Eduard
E
Lafuente
Amalia
A
D000328:Adult; D000483:Alleles; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D008995:Monoamine Oxidase / Q000235:genetics / Q000378:metabolism*; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000453:epidemiology / Q000378:metabolism*
D050483:Dopamine Plasma Membrane Transport Proteins; D019389:Cytochrome P-450 CYP2D6; D008995:Monoamine Oxidase; D004298:Dopamine