[Reproductive potential of women with epilepsy].
An aim of the article was to study reproductive health of 218 women with epilepsy who were long-term treated with antiepileptic drugs (AED). A comparison group included 47 patients with polycystic ovary syndrome (PCOS). Women with epilepsy were stratified into 2 groups: group 1 included 107 women of reproductive age and group 2 - 111 pregnant women with epilepsy. In group 1, 27,7% women had ovary dysfunction, 7,2% - hypoprogesteronemia and 27% - hyperprolactinemia. There was no signs characteristic of diagnosis of PCOS in women with epilepsy compared to the women with PCOS. Menstrual cycle disturbances were reversible. The pregnant women were stratified into 2 subgroups: subgroup A consisted of women who were prepared for pregnancy by the epileptologist, subgroup B included women with unplanned pregnancy. The comparative study of the pregnancy course in these subgroups revealed that in subgroup A the compliance to treatment was higher and pregnancy and delivery were more successful as compared to subgroup B. Preparing for pregnancy and its planning together with epileptologist allows to control for seizures using minimal doses of AED and decreases pregnancy and delivery complications.
Zhidkova
I A
IA
Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet; Meditsinskiĭ tsentr Nevro-med, Moskva. Irina.Zhidkova@gmail.com
Karlov
V A
VA
Kun'kina
Iu B
IuB
Zlatorunskaia
M A
MA
Braginskaia
S G
SG
Kaznacheeva
T V
TV
Kozhokaru
A B
AB
D000293:Adolescent; D000328:Adult; D004827:Epilepsy / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D005831:Genital Diseases, Female / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications; D011379:Prognosis; D012098:Reproduction / Q000502:physiology*; D055815:Young Adult