title: Dynamic kinetic asymmetric transformation (DYKAT) by combined amine- and transition-metal-catalyzed enantioselective cycloisomerization.
abstract: The first examples of one-pot highly chemo- and enantioselective dynamic kinetic asymmetric transformations (DYKATs) involving alpha,beta-unsaturated aldehydes and propargylated carbon acids are presented. These DYKATs, which proceed by a combination of catalytic iminium activation, enamine activation, and Pd(0)-catalyzed enyne cycloisomerization, give access to functionalized cyclopentenes with up to 99 % ee and can be used for the generation of all-carbon quaternary stereocenters.
authors.affiliation: Department of Organic Chemistry, The Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden.
authors.forename: Gui-Ling
authors.initials: GL
authors.lastname: Zhao
authors.forename: Farman
authors.initials: F
authors.lastname: Ullah
authors.forename: Luca
authors.initials: L
authors.lastname: Deiana
authors.forename: Shuangzheng
authors.initials: S
authors.lastname: Lin
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhang
authors.forename: Junliang
authors.initials: J
authors.lastname: Sun
authors.forename: Ismail
authors.initials: I
authors.lastname: Ibrahem
authors.forename: Pawel
authors.initials: P
authors.lastname: Dziedzic
authors.forename: Armando
authors.initials: A
authors.lastname: Córdova
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry; D007700:Kinetics; D056004:Molecular Dynamics Simulation; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D028561:Transition Elements / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D003517:Cyclopentanes; D028561:Transition Elements; D010165:Palladium