title: Ribosomal therapy in the treatment of recurrent acute adenoiditis.
abstract: The aim of this study was to evaluate the efficacy of an oral ribosomal immunotherapy in the management of children with recurrent acute adenoiditis (RAA). 60 children with RAA were included and randomly assigned into two groups (group A and B). Group A children underwent ribosomal prophylaxis, while group B received a placebo. Before, at the end and 6 months after start of the therapy, children underwent medical history, ENT examination, plasma levels of immunoglobulins class E, A, G, M (IgE, IgA, IgG, IgM), tympanometry, active anterior rhinomanometry and VAS scores by children' parents. After the treatment and at the end of the study, in the group A, the serum concentration of IgE was significantly (P < 0.05) lower than in group B (77.34 +/- 6.23 vs. 95.49 +/- 7.07 mg/dl; 74.82 +/- 6.26 vs. 94.44 +/- 7.44 mg/dl), IgA titers were significantly (P < 0.05) higher than in group B (312.04 +/- 18.41 vs. 213.20 +/- 11.82; 309.07 +/- 18.33 vs. 211.73 +/- 11.54 mg/dl) as well as serum concentration of IgG (1401.12 +/- 118.81 vs. 1101.81 +/- 109.64 mg/dl; 1412.19 +/- 116.43 vs. 1144.06 +/- 103.58 mg/dl). At the end of the study, comparison between the two groups showed, in group A: 77% of children (n = 23), versus 23% (n = 7) of group B, with a type A tympanogram; significant (P < 0.05) nasal flow decrease at the rhinomanometric measures; VAS scores were significantly (P < 0.05) improved (1.8 +/- 0.22 vs. 5.1 +/- 0.59) and frequency, severity and social impact of RAA episodes were significantly (P < 0.05) lower than group B. Our results show the therapeutic effectiveness of this approach in the prophylaxis of recurrent acute adenoiditis.
authors.affiliation: ENT Department, University of Genoa, Genoa, Italy. renzomora@libero.it
authors.forename: Renzo
authors.initials: R
authors.lastname: Mora
authors.forename: Massimo
authors.initials: M
authors.lastname: Dellepiane
authors.forename: Barbara
authors.initials: B
authors.lastname: Crippa
authors.forename: Luca
authors.initials: L
authors.lastname: Guastini
authors.forename: Valentina
authors.initials: V
authors.lastname: Santomauro
authors.forename: Angelo
authors.initials: A
authors.lastname: Salami
mesh_terms: D000158:Acoustic Impedance Tests; D000234:Adenoids; D000293:Adolescent; D000942:Antigens, Bacterial / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007136:Immunoglobulins / Q000097:blood; D007155:Immunologic Factors / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D009304:Nasopharyngitis / Q000188:drug therapy* / Q000276:immunology; D010147:Pain Measurement; D025363:Rhinomanometry; D055502:Secondary Prevention
chemical_list: D000942:Antigens, Bacterial; D007136:Immunoglobulins; D007155:Immunologic Factors; C034206:Ribomunyl; D007073:Immunoglobulin E