title: Clinical and model research of neurotrauma.
abstract: Modeling traumatic brain injury represents a major challenge for neuroscientists - to represent extremely complex pathobiological processes kept under close surveillance in the most complex organ of a laboratory animal. To ensure that such models also reflect those alterations evoked by and/or associated with traumatic brain injury (TBI) in man, well-defined, graded, simple injury paradigms should be used with clear endpoints that also enable us to assess the relevance of our findings to human observations. It is of particular importance that our endpoints should harbor clinical significance, and to this end, biological markers ultimately associated with the pathological processes operant in TBI are considered the best candidate. This chapter provides protocols for relevant experimental models of TBI and clinical materials for neuroproteomic analysis.
authors.affiliation: Department of Neurosurgery, Pécs University, Pécs, Hungary. andras.buki@aok.pte.huc
authors.forename: András
authors.initials: A
authors.lastname: Büki
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Kövesdi
authors.forename: József
authors.initials: J
authors.lastname: Pál
authors.forename: Endre
authors.initials: E
authors.lastname: Czeiter
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D009419:Nerve Tissue Proteins / Q000032:analysis; D020543:Proteome / Q000032:analysis; D040901:Proteomics / Q000379:methods*; D051381:Rats
chemical_list: D009419:Nerve Tissue Proteins; D020543:Proteome