title: [A case of secondary pulmonary alveolar proteinosis associated with myelodysplastic syndrome, complicated with disseminated M. abscessus infection].
abstract: A 27-year-old man was admitted to our hospital complaining of a persistent high fever since August 2007. Chest radiography showed infiltration shadows in the right lower lung field. Chest CT revealed scattered small nodular shadows and patchy consolidations in the right lower lobe. He was diagnosed as secondary pulmonary alveolar proteinosis (sPAP) associated with myelodysplastic syndrome (MDS), confirmed by video-assisted thoracic surgery (VATS) and bone marrow aspiration. Sera were negative for anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody. He developed a subcutaneous abscess and meningitis caused by M. absessus after VATS. After a long-course of antibiotic therapy, an allogenic peripheral blood stem cell transplantation was performed. But he died of graft versus host disease and M. abscessus sepsis 87 days after transplantation.
authors.affiliation: Kyushu Kousei Nenkin Hospital, Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University.
authors.forename: Yukari
authors.initials: Y
authors.lastname: Asai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ouchi
authors.forename: Tukasa
authors.initials: T
authors.lastname: Ohosima
authors.forename: Ryuji
authors.initials: R
authors.lastname: Nakano
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Yamano
authors.forename: Ichiro
authors.initials: I
authors.lastname: Inoshima
authors.forename: Takuji
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fukuyama
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Inoue
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakanishi
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D009165:Mycobacterium Infections, Nontuberculous / Q000150:complications*; D009190:Myelodysplastic Syndromes / Q000150:complications*; D011649:Pulmonary Alveolar Proteinosis / Q000209:etiology* / Q000628:therapy