title: Gd(III)-nanodiamond conjugates for MRI contrast enhancement.
abstract: A Gd(III)-nanodiamond conjugate [Gd(III)-ND] was prepared and characterized, enabling detection of nanodiamonds by MR imaging. The Gd(III)-ND particles significantly reduced the T(1) of water protons with a per-Gd(III) relaxivity of 58.82 +/- 1.18 mM(-1) s(-1) at 1.5 T (60 MHz). This represents a 10-fold increase compared to the monomer Gd(III) complex (r(1) = 5.42 +/- 0.20 mM(-1) s(-1)) and is among the highest per-Gd(III) relaxivities reported.
authors.affiliation: Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Manus
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Mastarone
authors.forename: Emily A
authors.initials: EA
authors.lastname: Waters
authors.forename: Xue-Qing
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Elise A
authors.initials: EA
authors.lastname: Schultz-Sikma
authors.forename: Keith W
authors.initials: KW
authors.lastname: Macrenaris
authors.forename: Dean
authors.initials: D
authors.lastname: Ho
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Meade
mesh_terms: D000818:Animals; D002151:Calorimetry / Q000379:methods; D003287:Contrast Media / Q000494:pharmacology*; D018130:Diamond; D005682:Gadolinium / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008968:Molecular Conformation; D041681:NIH 3T3 Cells; D050997:Nanomedicine / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*
chemical_list: D003287:Contrast Media; D018130:Diamond; D005682:Gadolinium