title: Blueberry supplementation improves memory in older adults.
abstract: The prevalence of dementia is increasing with expansion of the older adult population. In the absence of effective therapy, preventive approaches are essential to address this public health problem. Blueberries contain polyphenolic compounds, most prominently anthocyanins, which have antioxidant and anti-inflammatory effects. In addition, anthocyanins have been associated with increased neuronal signaling in brain centers, mediating memory function as well as improved glucose disposal, benefits that would be expected to mitigate neurodegeneration. This study investigated the effects of daily consumption of wild blueberry juice in a sample of nine older adults with early memory changes. At 12 weeks, improved paired associate learning (p = 0.009) and word list recall (p = 0.04) were observed. In addition, there were trends suggesting reduced depressive symptoms (p = 0.08) and lower glucose levels (p = 0.10). We also compared the memory performances of the blueberry subjects with a demographically matched sample who consumed a berry placebo beverage in a companion trial of identical design and observed comparable results for paired associate learning. The findings of this preliminary study suggest that moderate-term blueberry supplementation can confer neurocognitive benefit and establish a basis for more comprehensive human trials to study preventive potential and neuronal mechanisms.
authors.affiliation: Department of Psychiatry, University of Cincinnati Academic Health Center, Cincinnati, Ohio 45267-0559, USA. robert.krikorian@uc.edu
authors.forename: Robert
authors.initials: R
authors.lastname: Krikorian
authors.forename: Marcelle D
authors.initials: MD
authors.lastname: Shidler
authors.forename: Tiffany A
authors.initials: TA
authors.lastname: Nash
authors.forename: Wilhelmina
authors.initials: W
authors.lastname: Kalt
authors.forename: Melinda R
authors.initials: MR
authors.lastname: Vinqvist-Tymchuk
authors.forename: Barbara
authors.initials: B
authors.lastname: Shukitt-Hale
authors.forename: James A
authors.initials: JA
authors.lastname: Joseph
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D029798:Blueberry Plants / Q000737:chemistry*; D019587:Dietary Supplements / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts