title: Four new ent-kauranoids from Isodon rubescens var. lushanensis and data reassignment of dayecrystal B.
abstract: Four new 7, 20-epoxy-ent-kauranoids, rubluanins A-D (1-4) and eleven known ones, were isolated from Isodon rubescens var. lushanensis, and their structures were elucidated by spectroscopic analysis. Compounds 2-14 were evaluated for their cytotoxicity in several human tumor cell lines (U937, Jurkat, HL-60, K562, SGC790, and HepG2). Among the compounds, lasiokaurin (13) showed significant cytotoxic activity of 0.62 microM (IC(50)) in U937 cells.
authors.affiliation: Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Zhang
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Wang
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Xiao
authors.initials: X
authors.lastname: Luo
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis* / Q000302:isolation & purification / Q000493:pharmacokinetics*; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D045786:Diterpenes, Kaurane / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045786:Diterpenes, Kaurane; C011893:lasiokaurin