title: Clonal dissemination of Klebsiella pneumoniae carbapenemase KPC-3 in Long Beach, California.
abstract: Carbapenems (CARBs) are the primary treatment for infections caused by extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae strains. Production of a serine carbapenemase, KPC, is increasing alarmingly in the United States and is probably contributing to CARB resistance rates. We describe the clinical and molecular characteristics of four infections caused by KPC-3 K. pneumoniae strains.
authors.affiliation: University of California, San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, 9500 Gilman Drive, MC 0714, La Jolla, CA 92093-0714, USA. jenle@ucsd.edu.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Le
authors.forename: Mariana
authors.initials: M
authors.lastname: Castanheira
authors.forename: David S
authors.initials: DS
authors.lastname: Burgess
authors.forename: Barbara
authors.initials: B
authors.lastname: McKee
authors.forename: Raza
authors.initials: R
authors.lastname: Iqbal
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Jones
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics; D002140:California; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology* / Q000473:pathology*; D007711:Klebsiella pneumoniae / Q000145:classification* / Q000201:enzymology* / Q000302:isolation & purification; D007902:Length of Stay; D008875:Middle Aged; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001618:beta-Lactamases; C495220:beta-lactamase KPC-3, Klebsiella pneumoniae