Variability order of the latent and the infectious periods in a deterministic SEIR epidemic model and evaluation of control effectiveness.
We use distribution theory and ordering of non-negative random variables to study the Susceptible-Exposed-Infectious-Removed (SEIR) model with two control measures, quarantine and isolation, to reduce the spread of an infectious disease. We identify that the probability distributions of the latent period and the infectious period are primary features of the SEIR model to formulate the epidemic threshold and to evaluate the effectiveness of the intervention measures. If the primary features are changed, the conclusions will be altered in an importantly different way. For the latent and infectious periods with known mean values, it is the dilation, a generalization of variance, of their distributions that ranks the effectiveness of these control measures. We further propose ways to set quarantine and isolation targets to reduce the controlled reproduction number below the threshold using observed initial growth rate from outbreak data. If both quarantine and isolation are 100% effective, one can directly use the observed growth rate for setting control targets. If they are not 100% effective, some further knowledge of the distributions is required.
Yan
Ping
P
Public Health Agency of Canada, Ontario, Canada. Ping_Yan@phac-aspc.gc.ca
Feng
Zhilan
Z
D000465:Algorithms; D050936:Basic Reproduction Number; D003140:Communicable Disease Control; D003141:Communicable Diseases / Q000453:epidemiology* / Q000382:microbiology / Q000628:therapy / Q000635:transmission; D006801:Humans; D008954:Models, Biological; D010356:Patient Isolation; D015397:Program Evaluation; D011790:Quarantine; D016008:Statistical Distributions