title: Perioperative metabolic changes in patients undergoing cardiac surgery.
abstract: Perioperative metabolic changes in cardiac surgical patients are not only induced by tissue injury and extracorporeal circulation per se: the systemic inflammatory response to surgical trauma and extracorporeal circulation, perioperative hypothermia, cardiovascular and neuroendocrine responses, and drugs and blood products used to maintain cardiovascular function and anesthesia contribute to varying degrees. The pathophysiologic changes include increased oxygen consumption and energy expenditure; increased secretion of adrenocorticotrophic hormone, cortisol, epinephrine, norepinephrine, insulin, and growth hormone; and decreased total tri-iodothyronine levels. Easily measurable metabolic consequences of these changes include hyperglycemia, hyperlactatemia, increased aspartate, glutamate and free fatty acid concentrations, hypokalemia, increased production of inflammatory cytokines, and increased consumption of complement and adhesion molecules. Nutritional risk before elective cardiac surgery-defined as preoperative unintended pathologic weight loss/low amount of food intake in the preceding week or low body mass index-is related to adverse postoperative outcome. Improvements in surgical techniques, anesthesia, and perioperative management have been designed to minimize the stressful stimulus to catabolism, thereby slowing the wasting process to the point where much less nutrition is required to meet metabolic requirements. Early nutrition in cardiac surgery is safe and well tolerated.
authors.affiliation: Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland. stephan.jakob@insel.ch
authors.forename: Stephan M
authors.initials: SM
authors.lastname: Jakob
authors.forename: Zeno
authors.initials: Z
authors.lastname: Stanga
mesh_terms: D018663:Adrenergic Agents / Q000378:metabolism; D000777:Anesthetics / Q000378:metabolism*; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002395:Catecholamines / Q000378:metabolism; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007431:Intraoperative Complications / Q000378:metabolism / Q000517:prevention & control; D009490:Neurosecretory Systems / Q000378:metabolism; D009752:Nutritional Status; D018529:Nutritional Support; D019990:Perioperative Care / Q000379:methods*; D011183:Postoperative Complications / Q000378:metabolism* / Q000517:prevention & control*; D018746:Systemic Inflammatory Response Syndrome / Q000378:metabolism
chemical_list: D018663:Adrenergic Agents; D000777:Anesthetics; D002395:Catecholamines; D006728:Hormones