title: Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
abstract: A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case-control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case-control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate-adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19-2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12-1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52-1.31), breast cancer (OR = 1.21, 95% CI = 0.97-1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93-1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.
authors.affiliation: Department of Epidemiology, American Cancer Society, Atlanta, GA, USA. ejacobs@cancer.org
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Jacobs
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: Charles S
authors.initials: CS
authors.lastname: Fuchs
authors.forename: Andrea
authors.initials: A
authors.lastname: Lacroix
authors.forename: Robert R
authors.initials: RR
authors.lastname: McWilliams
authors.forename: Emily
authors.initials: E
authors.lastname: Steplowski
authors.forename: Rachael Z
authors.initials: RZ
authors.lastname: Stolzenberg-Solomon
authors.forename: Alan A
authors.initials: AA
authors.lastname: Arslan
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Myron
authors.initials: M
authors.lastname: Gross
authors.forename: Kathy
authors.initials: K
authors.lastname: Helzlsouer
authors.forename: Gloria
authors.initials: G
authors.lastname: Petersen
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Ilir
authors.initials: I
authors.lastname: Agalliu
authors.forename: Naomi E
authors.initials: NE
authors.lastname: Allen
authors.forename: Laufey
authors.initials: L
authors.lastname: Amundadottir
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Boutron-Ruault
authors.forename: Julie E
authors.initials: JE
authors.lastname: Buring
authors.forename: Federico
authors.initials: F
authors.lastname: Canzian
authors.forename: Sandra
authors.initials: S
authors.lastname: Clipp
authors.forename: Miren
authors.initials: M
authors.lastname: Dorronsoro
authors.forename: J Michael
authors.initials: JM
authors.lastname: Gaziano
authors.forename: Edward L
authors.initials: EL
authors.lastname: Giovannucci
authors.forename: Susan E
authors.initials: SE
authors.lastname: Hankinson
authors.forename: Patricia
authors.initials: P
authors.lastname: Hartge
authors.forename: Robert N
authors.initials: RN
authors.lastname: Hoover
authors.forename: David J
authors.initials: DJ
authors.lastname: Hunter
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Jacobs
authors.forename: Mazda
authors.initials: M
authors.lastname: Jenab
authors.forename: Peter
authors.initials: P
authors.lastname: Kraft
authors.forename: Charles
authors.initials: C
authors.lastname: Kooperberg
authors.forename: Shannon M
authors.initials: SM
authors.lastname: Lynch
authors.forename: Malin
authors.initials: M
authors.lastname: Sund
authors.forename: Julie B
authors.initials: JB
authors.lastname: Mendelsohn
authors.forename: Tracy
authors.initials: T
authors.lastname: Mouw
authors.forename: Christina C
authors.initials: CC
authors.lastname: Newton
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Petra H M
authors.initials: PH
authors.lastname: Peeters
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Rajkovic
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.forename: Gilles
authors.initials: G
authors.lastname: Thomas
authors.forename: Geoffrey S
authors.initials: GS
authors.lastname: Tobias
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Trichopoulos
authors.forename: Jarmo
authors.initials: J
authors.lastname: Virtamo
authors.forename: Jean
authors.initials: J
authors.lastname: Wactawski-Wende
authors.forename: Brian M
authors.initials: BM
authors.lastname: Wolpin
authors.forename: Kai
authors.initials: K
authors.lastname: Yu
authors.forename: Anne
authors.initials: A
authors.lastname: Zeleniuch-Jacquotte
mesh_terms: D016022:Case-Control Studies; D015331:Cohort Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000235:genetics