Pre-treatment with mild UV irradiation suppresses reproductive toxicity induced by subsequent cadmium exposure in nematodes.
In nematodes, 10 J/m(2)/min of UV irradiation induced a mild reproductive toxicity. Pre-treatment with UV irradiation at 10 J/m(2)/min suppressed the formation of reproductive defects, and activated a noticeable reduction of percentage of population with hsp-16.2::gfp expression, an obvious elevation of superoxide dismutase activities, and decrease of oxidative damage in 50 and 100 microM Cd exposed nematodes; however, pre-treatment with UV irradiation at 20 J/m(2)/min caused a significant decrease of brood sizes or increase of generation times in Cd-exposed nematodes. Pre-treatment with mild UV irradiation did not suppress the formation of reproductive defects in 150 microM Cd-exposed nematodes. Furthermore, the adaptive response to reproductive toxicity from Cd exposure was not observed in a reactive oxygen species sensitive mev-1(kn1) mutant. Therefore, pre-treatment with mild UV irradiation triggers the resistance to reproductive toxicity from Cd exposure by at least partially inducing adaptation to oxidative stress and through a mev-1-dependent pathway.
Wang
Dayong
D
Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Department of Biochemistry and Molecular Biology, Southeast University Medical School, Nanjing 210009, China. dayongw@seu.edu.cn
Xing
Xiaojuan
X
D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D012734:Disorders of Sex Development; D006360:Heat-Shock Proteins / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D007246:Infertility / Q000139:chemically induced / Q000517:prevention & control*; D009348:Nematoda / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D010058:Oviposition / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects / Q000528:radiation effects; D012098:Reproduction / Q000187:drug effects* / Q000528:radiation effects; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D014466:Ultraviolet Rays
D029742:Caenorhabditis elegans Proteins; D006360:Heat-Shock Proteins; C108431:hsp-16.2 protein, C elegans; D013482:Superoxide Dismutase