Susceptibility for ischemic stroke in four constitution medicine is associated with polymorphisms of FCGR2A and IL1RN genes.
OBJECTIVE
To determine the association between Four Constitutional classification and Fc fragment of IgG, low affinity of IIa, receptor (FCGR2A) and interleukin 1 receptor antagonist (IL1RN) in Korean ischemic stroke patients.


METHODS
We classified the Four Constitutional types in ischemic stroke patients (n=162) and healthy control subjects (n=135), and genotyped FCGR2A and IL1RN polymorphisms using direct DNA sequencing and polymerase chain reaction (PCR) methods.


RESULTS
In the IL1RN polymorphisms, the IL1RN*1/IL1RN*2 genotype (OR=5.80, p=0.0142), and in the FCGR2A polymorphisms, the rs7535475 (OR=0.58, p=0.0218) and rs7512140 (OR=0.09, p=0.0335), were significantly associated with ischemic stroke. The prevalence of IL1RN*1/IL1RN*2 genotype of IL1RN and rs7535475 of FCGR2A in greater Yin person ischemic stroke patients were different from greater Yin person healthy controls (OR=18.97, p=0.0063; OR=0.38, p=0.0045).


CONCLUSIONS
These results suggest that IL1RN*1/IL1RN*2 genotype in greater Yin person might be associated with increased risk of ischemic stroke, and rs7535475 of FCGR2A might be associated with decreased risk of ischemic stroke. Furthermore, this relationship could provide the basis for a new approach in investigating the etiology of ischemic stroke.
Lee
Byung-Cheol
BC
Department of Internal Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Korea. hydrolee@korea.com
Lee
Hyejung
H
Park
Hun-Kuk
HK
Yang
Jong-Soo
JS
Chung
Joo-Ho
JH
D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D007723:Korea; D008297:Male; D055670:Medicine, Korean Traditional; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D015995:Prevalence; D017452:Receptors, IgG / Q000235:genetics*; D017422:Sequence Analysis, DNA; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*; D011795:Surveys and Questionnaires
C445323:FCGR2A protein, human; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D017452:Receptors, IgG