Synergistic effects between aminoethyl-chitosans and beta-lactams against methicillin-resistant Staphylococcus aureus (MRSA).
Two kinds of aminoethyl-chitosans (AEC), AEC90 and AEC50, which had degrees of deacetylation of 90% and 50%, respectively, were prepared and their synergistic effects in combination with beta-lactams including ampicillin, penicillin, and oxacillin against two standard methicillin-resistant Staphylococcus aureus (MRSA) strains and twelve clinical isolated MRSA strains were investigated. When AECs and beta-lactams were combined, synergistic effects were observed with fractional inhibitory concentration (FIC) indices of 0.252-0.508, and the MICs of beta-lactams in the presence of AECs were dramatically reduced.
Lee
Dae-Sung
DS
Department of Microbiology, Pukyong National University, Busan 608-737, Republic of Korea.
Kim
Young-Mog
YM
Lee
Myung-Suk
MS
Ahn
Chang-Bum
CB
Jung
Won-Kyo
WK
Je
Jae-Young
JY
D048271:Chitosan / Q000008:administration & dosage* / Q000737:chemistry; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology; D008826:Microbial Sensitivity Tests / Q000379:methods; D047090:beta-Lactams / Q000008:administration & dosage* / Q000737:chemistry
D047090:beta-Lactams; D048271:Chitosan