Significant weight loss in breastfed term infants readmitted for hyperbilirubinemia.
BACKGROUND
Weight loss of greater than 7% from birth weight indicates possible feeding problems. Inadequate oral intake causes weight loss and increases the bilirubin enterohepatic circulation. The objective of this study was to describe the association between total serum bilirubin (TSB) levels and weight loss in healthy term infants readmitted for hyperbilirubinemia after birth hospitalization.


METHODS
We reviewed medical records of breastfed term infants who received phototherapy according to TSB levels readmitted to Caja Petrolera de Salud Clinic in La Paz, Bolivia during January 2005 through October 2008.


RESULTS
Seventy-nine infants were studied (64.6% were males). The hyperbilirubinemia readmission rate was 5% among breastfed infants. Term infants were readmitted at a median age of 4 days. Mean TSB level was 18.6 +/- 3 mg/dL. Thirty (38%) had significant weight loss. A weak correlation between TSB levels and percent of weight loss was identified (r = 0.20; p < 0.05). The frequency of severe hyperbilirubinemia (> 20 mg/dL) was notably higher among infants with significant weight loss (46.7% vs. 18.4%; p < 0.05). The risk of having severe hyperbilirubinemia was approximately 4 times greater for infants with significant weight loss (OR: 3.9; 95% CI: 1.4-10.8; p < 0.05).


CONCLUSIONS
Significant weight loss could be a useful parameter to identify breastfed term infants at risk of severe hyperbilirubinemia either during birth hospitalization or outpatient follow-up visits in settings where routine pre-discharge TSB levels have not been implemented yet.
Salas
Ariel A
AA
Division of Pediatrics, Caja Petrolera de Salud Clinic, 2525 Arce Ave, San Jorge, La Paz, Bolivia. ariel.a.salas@gmail.com
Salazar
Jorge
J
Burgoa
Claudia V
CV
De-Villegas
Carlos A
CA
Quevedo
Valeria
V
Soliz
Amed
A
D001663:Bilirubin / Q000097:blood; D001942:Breast Feeding; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000097:blood / Q000628:therapy*; D007231:Infant, Newborn; D008297:Male; D010359:Patient Readmission; D010789:Phototherapy / Q000379:methods; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D015431:Weight Loss / Q000502:physiology*
D001663:Bilirubin