title: Overt diabetes mellitus adversely affects surgical outcomes of noncardiovascular patients.
abstract: BACKGROUND
  It is known that cardiac surgical patients with diabetes have greater peri-operative mortality and morbidity when compared with nondiabetic patients; the rate of adverse events in other surgery subspecialties has been only investigated minimally. The aim of this study was to test the magnitude of association between overt diabetes mellitus and postoperative complications across a spectrum of noncardiac surgical patients.
  
  
  METHODS
  Prospective outcome data registries describing 1,343 data sets from a spectrum of surgical subspecialties were examined to establish the prevalence of diagnosed diabetes, the incidence of intra- and postoperative complications, and the difference in proportion of morbidity between diabetic versus nondiabetic patients.
  
  
  RESULTS
  There was a significant difference in overall morbidity between diabetic and nondiabetic patients with a 2.0 and 1.6 times increased morbidity risk in known diabetic patients with and without malignancy, respectively. Known diabetes was related to the number of postoperative complications in noncardiovascular patients.
  
  
  CONCLUSIONS
  This study quantified the association between known diabetes and the occurrence of complications during recovery after a spectrum of noncardiac surgery. Because of a high prevalence of prediabetic and undiagnosed conditions, the strength of associations between glucose dysregulation and operative outcomes may be even greater than we report.
authors.affiliation: Department of Surgery, The Chinese University of Hong Kong, Hong Kong. wendyb@surgery.cuhk.edu.hk
authors.forename: Wendy F
authors.initials: WF
authors.lastname: Bower
authors.forename: Lawrence
authors.initials: L
authors.lastname: Jin
authors.forename: Malcolm J
authors.initials: MJ
authors.lastname: Underwood
authors.forename: Janet F
authors.initials: JF
authors.lastname: Lee
authors.forename: Kit F
authors.initials: KF
authors.lastname: Lee
authors.forename: Yuk H
authors.initials: YH
authors.lastname: Lam
authors.forename: Sui K
authors.initials: SK
authors.lastname: Ng
authors.forename: Alexander C
authors.initials: AC
authors.lastname: Vlantis
authors.forename: Paul B
authors.initials: PB
authors.lastname: Lai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003920:Diabetes Mellitus / Q000401:mortality*; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D009369:Neoplasms / Q000401:mortality* / Q000601:surgery*; D011183:Postoperative Complications / Q000401:mortality*; D015995:Prevalence; D012042:Registries; D012307:Risk Factors; D013896:Thoracic Diseases / Q000401:mortality* / Q000601:surgery*; D013959:Thyroid Diseases / Q000401:mortality / Q000601:surgery; D014652:Vascular Diseases / Q000401:mortality / Q000601:surgery; D055815:Young Adult