Lipid/particle assemblies based on maltodextrin-gum arabic core as bio-carriers.
A novel system to carry and protect epigallocatechin gallate (EGCG), an antioxidant from the green tea, is reported. The system consists of maltodextrin and gum arabic nanoparticles coated with egg-yolk l-alpha-phosphatidylcholine (Egg-PC)/stearylamine (SA) bilayers. In this study, the polysaccharide core was produced by homogenization followed by spray-drying. The lipid coating was performed by the lipid film hydration method. The polysaccharide core revealed negative zeta potential, which changed to opposite signs after lipid coating. The presence of lipid layers was evidenced by cryogenic-transmission (cryo-TEM) and scanning (cryo-SEM) electron microscopy studies. An increase in size was observed after lipid coating as determined by dynamic light scattering (DLS). Atomic force microscopy (AFM) demonstrated that the polysaccharide core provides high resistance to mechanical strength. The lipid/particle assemblies show high retention efficiency of EGCG at physiological pH, opening the possibility of their use for delivery and controlled release of tea catechins.
Gomes
Joana F P S
JF
LEPAE, Chemical Engineering Department, Faculty of Engineering, University of Porto, Rua Roberto Frias, 4200-465 Porto, Portugal. joana.gomes@fe.up.pt
Rocha
Sandra
S
do Carmo Pereira
Maria
M
Peres
Ivone
I
Moreno
Susana
S
Toca-Herrera
José
J
Coelho
Manuel A N
MA
D000588:Amines / Q000737:chemistry*; D002392:Catechin / Q000031:analogs & derivatives / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D004530:Egg Yolk / Q000737:chemistry*; D006170:Gum Arabic / Q000737:chemistry*; D008567:Membranes, Artificial; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*; D013499:Surface Properties
D000588:Amines; D004337:Drug Carriers; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D011134:Polysaccharides; C008315:maltodextrin; D002392:Catechin; D006170:Gum Arabic; C045651:epigallocatechin gallate; C009317:stearylamine