title: A study comparing chemical peeling using modified Jessner's solution and 15% trichloroacetic Acid versus 15% trichloroacetic acid in the treatment of melasma.
abstract: BACKGROUND
  Melasma is a symmetric progressive hyperpigmentation of the facial skin that occurs in all races but has a predilection for darker skin phenotypes. Depigmenting agents, laser and chemical peeling as classic Jessner's solution, modified Jessner's solution and trichloroacetic acid have been used alone and in combination in the treatment of melasma.
  
  
  OBJECTIVE
  The aim of the study was to compare the therapeutic effect of combined 15% Trichloroacetic acid (TCA) and modified Jessner's solution with 15% TCA on melasma.
  
  
  METHODS
  Twenty married females with melasma (epidermal type), with a mean age of 38.25 years, were included in this study. All were of skin type III or IV. Fifteen percent TCA was applied to the whole face, with the exception of the left malar area to which combined TCA 15% and modified Jessner's solution was applied.
  
  
  RESULTS
  Our results revealed statistically highly significant difference between MASI Score (Melasma Area and Severity Index) between the right malar area and the left malar area.
  
  
  CONCLUSIONS
  Modified Jessner's solution proved to be useful as an adjuvant treatment with TCA in the treatment of melasma, improving the results and minimizing postinflammatory hyperpigmentation.
authors.affiliation: Department of Dermatology, Cairo University, Cairo, Egypt. omar_safoury@hotmail.com
authors.forename: Omar Soliman
authors.initials: OS
authors.lastname: Safoury
authors.forename: Nagla Mohamed
authors.initials: NM
authors.lastname: Zaki
authors.forename: Eman Ahmad
authors.initials: EA
authors.lastname: El Nabarawy
authors.forename: Eman Abas
authors.initials: EA
authors.lastname: Farag