An evaluation of the genotoxic and cytotoxic effects of the anti-obesity drugs sibutramine and fenproporex.
Anti-obesity medications deserve special considerations at the present time due to an increasing number of overweight and obese people who require these therapeutic alternatives. Obesity is positively associated with several chronic illnesses, including cancer. In this work, we evaluated the possible genotoxic and/or cytotoxic actions of two drugs, sibutramine and fenproporex, in the doses of 10, 20 and 40 mg/kg body weight (bw), administered intraperitoneally in male Swiss mice. The genotoxic effect was analyzed by comet assay and micronucleus test. We found that both drugs increased the frequency of genotoxic damage in Swiss mice, but did not present cytotoxic activities towards the polychromatic erythrocytes of the bone marrow of these animals.
da Silva
Cristiano José
CJ
Department of Genetics, Faculty of Medicine of Ribeirão Preto, São Paulo University, São Paulo, Brazil. profeta@usp.br
dos Santos
José Ernesto
JE
Satie Takahashi
Catarina
C
D000662:Amphetamines / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000633:toxicity*; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000473:pathology; D020552:Comet Assay; D003503:Cyclobutanes / Q000008:administration & dosage / Q000633:toxicity*; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced*; D018570:Risk Assessment
D000662:Amphetamines; D019440:Anti-Obesity Agents; D003503:Cyclobutanes; C026013:fenproporex; C058254:sibutramine