title: Reduction in the risk of prostate cancer: future directions after the Prostate Cancer Prevention Trial.
abstract: The landmark Prostate Cancer Prevention Trial (PCPT) generated interest in the potential health benefits and cost of reducing prostate cancer risk--specifically, the potential role of 5alpha-reductase inhibitors. However, the PCPT raised several unanswered questions, including the cause and significance of the increased incidence of high-grade tumors associated with finasteride. In the present study, we review the PCPT findings and unanswered questions, next steps in this field, and ongoing prostate cancer prevention trials addressing these unanswered questions. Particular emphasis is placed on the design of the second large-scale trial of a 5alpha-reductase inhibitor, the REduction by DUtasteride of prostate Cancer Events (REDUCE) trial.
authors.affiliation: Department of Urologic Oncology, University of Colorado Health Sciences Center, Denver, Colorado, USA. david.crawford@ucdenver.edu
authors.forename: E David
authors.initials: ED
authors.lastname: Crawford
authors.forename: Gerald L
authors.initials: GL
authors.lastname: Andriole
authors.forename: Michael
authors.initials: M
authors.lastname: Marberger
authors.forename: Roger S
authors.initials: RS
authors.lastname: Rittmaster
mesh_terms: D018890:Chemoprevention; D002986:Clinical Trials as Topic; D005544:Forecasting; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000517:prevention & control*; D012307:Risk Factors