Clinical biomarkers in esophageal adenocarcinoma.
This review describes genetic and molecular changes related to adenocarcinoma of the esophagus and gastroesophageal junction (GEJ) with emphasis on prognostic value and possibilities for targeted therapy in clinical setting. The progression of Barrett's esophagus to adenocarcinoma has been the focus of particular scrutiny, and a number of potential tissue and serum-based disease biomarkers have emerged. Tissue biomarkers allowing risk stratification of Barrett's are reviewed as well as strategies currently being used to discover novel biomarkers that will facilitate the early detection of esophageal adenocarcinoma.
Biondi
Antonio
A
Section of General Surgery and Oncology, Department of General Surgery, University Medical School of Catania, Catania, Italy. biondian@tin.it
Migliore
Marcello
M
Strano
Giuseppe
G
Vadala
Salvatore
S
Tropea
Alessandro
A
Basile
Francesco
F
D000230:Adenocarcinoma / Q000175:diagnosis*; D001471:Barrett Esophagus / Q000175:diagnosis*; D014408:Biomarkers, Tumor / Q000097:blood / Q000652:urine; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000175:diagnosis*; D005819:Genetic Markers; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D009092:Mucous Membrane / Q000000981:diagnostic imaging; D012307:Risk Factors; D014463:Ultrasonography
D014408:Biomarkers, Tumor; D005819:Genetic Markers