title: Toxicity evaluation and prediction of toxic chemicals on activated sludge system.
abstract: The gaps of data for evaluating toxicity of new or overloaded organic chemicals on activated sludge system resulted in the requirements for methodology of toxicity estimation. In this study, 24 aromatic chemicals typically existed in the industrial wastewater were selected and classified into three groups of benzenes, phenols and anilines. Their toxicity on activated sludge was then investigated. Two indexes of IC(50-M) and IC(50-S) were determined respectively from the respiration rates of activated sludge with different toxicant concentration at mid-term (24h) and short-term (30min) time intervals. Experimental results showed that the group of benzenes was the most toxic, followed by the groups of phenols and anilines. The values of IC(50-M) of the tested chemicals were higher than those of IC(50-S). In addition, quantitative structure-activity relationships (QSARs) models developed from IC(50-M) were more stable and accurate than those of IC(50-S). The multiple linear models based on molecular descriptors and K(ow) presented better reliability than single linear models based on K(ow). Among these molecular descriptors, E(lumo) was the most important impact factor for evaluation of mid-term toxicity.
authors.affiliation: State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai, China.
authors.forename: Bijing
authors.initials: B
authors.lastname: Cai
authors.forename: Li
authors.initials: L
authors.lastname: Xie
authors.forename: Dianhai
authors.initials: D
authors.lastname: Yang
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Arcangeli
mesh_terms: D000814:Aniline Compounds / Q000633:toxicity; D001555:Benzene Derivatives / Q000633:toxicity; D006841:Hydrocarbons, Aromatic / Q000633:toxicity*; D007220:Industrial Waste / Q000517:prevention & control; D009930:Organic Chemicals / Q000633:toxicity; D010636:Phenols / Q000633:toxicity; D021281:Quantitative Structure-Activity Relationship; D012722:Sewage / Q000009:adverse effects*; D018675:Toxicity Tests; D014874:Water Pollutants, Chemical
chemical_list: D000814:Aniline Compounds; D001555:Benzene Derivatives; D006841:Hydrocarbons, Aromatic; D007220:Industrial Waste; D009930:Organic Chemicals; D010636:Phenols; D012722:Sewage; D014874:Water Pollutants, Chemical