Rare human IFNG variants.
After the identification of the human interferon-gamma (IFNG) variant G54D (c.287G>A, ss105106770) in DNA samples from Ghana, West Africa, systematic mutation screening of IFNG by the LightCycler((R))-based procedure of high-resolution melting (HRM) revealed additional rare mutations. All variants occurred heterozygously only and were confirmed either by their detection in other individuals and/or by repeated DNA sequencing of independent PCR products.
Thye
Thorsten
T
Bernhard Nocht Institute for Tropical Medicine, Department of Molecular Medicine, Hamburg, Germany.
Ehmen
Christa
C
Intemann
Christopher D
CD
Chinbuah
Margaret Amanua
MA
Ziegler
Andreas
A
Horstmann
Rolf D
RD
Meyer
Christian G
CG
D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D009691:Nucleic Acid Denaturation; D012984:Software
D007371:Interferon-gamma