[Protective role of leptin in acute gastric ulcers].
There are few data concerning protective effects of leptin on gastric epithelium treated with necrotic factors: ethanol, bile salts and hiperosmotic solutions. Further investigations are needed to establish the role of hormone leptin in gastroprotection and in the process of chronic gastric ulcers healing in animals. Exogenous leptin administration plays protective effects against 75% ethanol damage in gastric epithelium. Nitric oxide is involved in gastroprotective effects of leptin and CCK.
Ptak-Belowska
Agata
A
Katedra Fizjologii, Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków, Poland. agata.ptak-belowska@uj.edu.pl
Brzozowski
Tomasz
T
Pajdo
Robert
R
Pawlik
Michał
M
Kwiecień
Sławomir
S
Drozdowicz
Danuta
D
Pawlik
Wiesław W
WW
D000208:Acute Disease; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D005753:Gastric Mucosa / Q000378:metabolism*; D020738:Leptin / Q000008:administration & dosage* / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000378:metabolism* / Q000517:prevention & control
D000897:Anti-Ulcer Agents; D020738:Leptin