title: ACE DD genotype is unfavorable to Korean short-term muscle power athletes.
abstract: The purpose of this study was to test the hypothesis that the ACE DD genotype is unfavorably associated with the ultimate power-oriented performance. To test the hypothesis we recruited a total of 848 subjects including 55 international level power-oriented athletes (High-performance), 100 national level power-oriented athletes (Mid-performance) and 693 healthy controls (Control) in Korea. Then the distributions of ACE polymorphism throughout these groups were analyzed. As a result, there was a gradual decrease of frequencies of the DD genotype with advancing levels of performance (Control vs. Mid-performance vs. High-performance=17.2% vs. 10.0% vs. 5.5%, p=0.002). Also, the frequencies of D allele decreased gradually with advancing levels of performance (Control vs. Mid-performance vs. High-performance=42.6% vs. 35.0% vs. 30.9%, p<0.01). Therefore, power-oriented athletes at the top level had a markedly diminished frequency of the DD genotype and the D allele. This finding gave 3.83 times lower probability of success in power-oriented sports for individuals with the DD genotype than those with the II+ ID genotype. In conclusion, these results indicate that Korean power-oriented athletes with a lower frequency of the DD genotype had a lower probability of success in power-oriented sports.
authors.affiliation: Eulji University School of Medicine, Physiology and Biophysics, Daejoen, Korea, Republic of Korea.
authors.forename: C-H
authors.initials: CH
authors.lastname: Kim
authors.forename: J-Y
authors.initials: JY
authors.lastname: Cho
authors.forename: J Y
authors.initials: JY
authors.lastname: Jeon
authors.forename: Y G
authors.initials: YG
authors.lastname: Koh
authors.forename: Y-M
authors.initials: YM
authors.lastname: Kim
authors.forename: H-J
authors.initials: HJ
authors.lastname: Kim
authors.forename: M
authors.initials: M
authors.lastname: Park
authors.forename: H-S
authors.initials: HS
authors.lastname: Um
authors.forename: C
authors.initials: C
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D056352:Athletes; D054874:Athletic Performance / Q000502:physiology*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D013177:Sports / Q000502:physiology*; D055815:Young Adult
chemical_list: D007703:Peptidyl-Dipeptidase A