title: [Evaluation of different combinations of components of Chinese formulation shuangshentongguan by using AUC values].
abstract: A sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was applied for the quantification of each component: tetrahydropalmatine (THP), dehydrocorydaline (DHC), salvianolic acid B (SAB), ginsenoside Rg1, Re, Rb1 and Rd in the Chinese herbal component SSTG (Shuangshentongguan) with different combinations. The pharmacokinetic data were analyzed with WinNonlin 5.2 software. The results showed that combination can increase the THP AUC value while the AUC values of SAB, ginsenoside Rg1, Re, Rb1 and Rd were reduced. These results showed significant differences. The AUC value of ginsenoside Rb1 was increased when combined with Danshen or Yanhusuo, but reduced when combined with Danshen and Yanhusuo. The DHC concentration in serum was too low to be determined.
authors.affiliation: Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.forename: Jian-Xun
authors.initials: JX
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chang-Ling
authors.initials: CL
authors.lastname: Duan
authors.forename: Cheng-Ren
authors.initials: CR
authors.lastname: Lin
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Fu
mesh_terms: D001572:Benzofurans / Q000493:pharmacokinetics*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics; D036145:Ginsenosides / Q000493:pharmacokinetics*; D010618:Phenanthrolines / Q000493:pharmacokinetics; D027561:Salvia miltiorrhiza; D053630:Depsides
chemical_list: D001572:Benzofurans; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D010618:Phenanthrolines; C028972:dan-shen root extract; C442759:ginsenoside Rb1; C076944:salvianolic acid B; D053630:Depsides; C035054:ginsenoside Rg1