Deficits in sensory-specific devaluation task performance following genetic deletions of cannabinoid (CB1) receptor.
Cannabinoid CB1 receptor is abundantly expressed throughout the CNS and is implicated in numerous physiological and behavioral functions, including appetite and feeding. In the present study, wild-type and CB1 heterozygous and homozygous knockout mice were tested on an instrumental outcome-selective devaluation task to assess changes in acquired instrumental response levels for a distinct food reward following selective satiation. Deletion of CB1 receptor, as well as reduction in CB1 expression (HET), produced deficits in outcome-selective instrumental devaluation. These results identify a critical role for CB1 receptor in the ability of animals to represent, update, and/or use sensory-specific outcome representations to alter appetitive behaviors.
Crombag
Hans S
HS
Neurogenetics and Behavior Center, Department of Psychological & Brain Sciences, The Johns Hopkins University, Baltimore, Maryland 21218, USA. h.crombag@sussex.ac.uk
Johnson
Alexander W
AW
Zimmer
Anne M
AM
Zimmer
Andreas
A
Holland
Peter C
PC
D000818:Animals; D001070:Appetitive Behavior / Q000502:physiology*; D017353:Gene Deletion; D007858:Learning / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics*; D012677:Sensation / Q000235:genetics; D013647:Task Performance and Analysis
C543264:Cnr1 protein, rat; D043884:Receptor, Cannabinoid, CB1