Design, synthesis and biological evaluation of simplified analogues of the RNA polymerase inhibitor etnangien.
Novel simplified analogues of the potent RNA polymerase inhibitor etnangien were obtained by total synthesis and evaluated for antibacterial activity against Gram-positive bacteria and one Gram-negative bacterium.
Menche
Dirk
D
Institut für Organische Chemie, Ruprecht-Karls-Universität Heidelberg, INF 270, D-69120 Heidelberg, Germany. dirk.menche@oci.uni-heidelberg.de
Li
Pengfei
P
Irschik
Herbert
H
D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development; D018942:Macrolides / Q000138:chemical synthesis* / Q000494:pharmacology*; D011090:Polyenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development
D018942:Macrolides; D011090:Polyenes; C521655:etnangien; D012321:DNA-Directed RNA Polymerases