Saliva cortisol and exposure to aircraft noise in six European countries.
BACKGROUND
Several studies show an association between exposure to aircraft or road traffic noise and cardiovascular effects, which may be mediated by a noise-induced release of stress hormones.


OBJECTIVE
Our objective was to assess saliva cortisol concentration in relation to exposure to aircraft noise.


METHODS
A multicenter cross-sectional study, HYENA (Hypertension and Exposure to Noise near Airports), comprising 4,861 persons was carried out in six European countries. In a subgroup of 439 study participants, selected to enhance the contrast in exposure to aircraft noise, saliva cortisol was assessed three times (morning, lunch, and evening) during 1 day.


RESULTS
We observed an elevation of 6.07 nmol/L [95% confidence interval (CI), 2.32-9.81 nmol/L] in morning saliva cortisol level in women exposed to aircraft noise at an average 24-hr sound level (L(Aeq,24h)) > 60 dB, compared with women exposed to L(Aeq,24h) < or = 50 dB, corresponding to an increase of 34%. Employment status appeared to modify the response. We found no association between noise exposure and saliva cortisol levels in men.


CONCLUSIONS
Our results suggest that exposure to aircraft noise increases morning saliva cortisol levels in women, which could be of relevance for noise-related cardiovascular effects.
Selander
Jenny
J
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. jenny.selander@ki.se
Bluhm
Gösta
G
Theorell
Töres
T
Pershagen
Göran
G
Babisch
Wolfgang
W
Seiffert
Ingeburg
I
Houthuijs
Danny
D
Breugelmans
Oscar
O
Vigna-Taglianti
Federica
F
Antoniotti
Maria Chiara
MC
Velonakis
Emmanuel
E
Davou
Elli
E
Dudley
Marie-Louise
ML
Järup
Lars
L
D000368:Aged; D000401:Aircraft; D002318:Cardiovascular Diseases / Q000209:etiology; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000009:adverse effects; D005060:Europe; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009624:Noise, Transportation / Q000009:adverse effects*; D012463:Saliva / Q000737:chemistry*; D012737:Sex Factors; D013997:Time Factors
D006854:Hydrocortisone