title: [Preparation and drug release property of paclitaxel nanoparticles].
abstract: OBJECTIVE
  To prepare paclitaxel nanoparticles and evaluate its drug release property in vitro.
  
  
  METHODS
  The chitosan-poly (lactide) copolymers were synthesized by ring-opening polymerization. Paclitaxel nanoparticles were prepared by the nanoprecipitation method. The encapsulation efficiency of the nanoparticles and the in vitro release of paclitaxel were studied.
  
  
  RESULTS
  The nanoparticles were fine and uniform spheres. The encapsulation efficiency of nanoparticles was up to 93.2%. The in vitro release profile showed the slow and stable release rate of paclitaxel.
  
  
  CONCLUSIONS
  This method is simple and the nanoparticles possess good physical performance as sustained release character in vitro.
authors.affiliation: National Center for Nanoscience and Technology, Beijing 100190, China. tieweiwang123@126.com
authors.forename: Tie-wei
authors.initials: TW
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Ming-jun
authors.initials: MJ
authors.lastname: Li
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Gao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D048271:Chitosan / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D019344:Lactic Acid / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D010316:Particle Size; D011091:Polyesters; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D048271:Chitosan; D017239:Paclitaxel