title: Vibralactones D-F from cultures of the basidiomycete Boreostereum vibrans.
abstract: Three new metabolites, vibralactones D-F (1-3) were isolated from cultures of the basidiomycete Boreostereum vibrans. The relative configuration of 1 was established on the basis of X-ray diffraction analysis, while the absolute configurations of 1-3 were assigned using a modified Mosher's method. Compound 1 showed weak inhibitory activities against isozymes of 11beta-hydroxysteroid dehydrogenases (HSD) with IC(50) values of 85.7 microM (human HSD1), 295.2 microM (mouse HSD1), and 87.1 microM (human HSD2).
authors.affiliation: Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
authors.forename: Meng-Yuan
authors.initials: MY
authors.lastname: Jiang
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Ze-Jun
authors.initials: ZJ
authors.lastname: Dong
authors.forename: Zhu-Liang
authors.initials: ZL
authors.lastname: Yang
authors.forename: Ying
authors.initials: Y
authors.lastname: Leng
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D042842:11-beta-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D002460:Cell Line; D018360:Crystallography, X-Ray; D006801:Humans; D007783:Lactones / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008958:Models, Molecular; D014162:Transfection
chemical_list: D007783:Lactones; C522315:vibralactone; D042842:11-beta-Hydroxysteroid Dehydrogenases