Phenyl-oxazoles, a new family of inverse agonists at the H(3) histamine receptor.
Denonne
Frédéric
F
UCB New Medicines, Chemin du Foriest, 1420 Braine-L'Alleud, Belgium. Frederic.denonne@ucb.com
Atienzar
Franck
F
Célanire
Sylvain
S
Christophe
Bernard
B
Delannois
Frédérique
F
Delaunoy
Christel
C
Delporte
Marie-Laure
ML
Durieu
Véronique
V
Gillard
Michel
M
Lallemand
Bénédicte
B
Lamberty
Yves
Y
Lorent
Geneviève
G
Vanbellinghen
Alain
A
Van Houtvin
Nathalie
N
Verbois
Valérie
V
Provins
Laurent
L
D000818:Animals; D001554:Benzene / Q000737:chemistry*; D018938:Caco-2 Cells; D002460:Cell Line; D003072:Cognition Disorders / Q000188:drug therapy; D054314:Drug Inverse Agonism; D006633:Histamine Antagonists / Q000737:chemistry*; D006801:Humans; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D010080:Oxazoles / Q000737:chemistry* / Q000493:pharmacokinetics; D011759:Pyrrolidines / Q000737:chemistry* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D018100:Receptors, Histamine H3 / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry / Q000493:pharmacokinetics
D006633:Histamine Antagonists; D010080:Oxazoles; D011759:Pyrrolidines; D018100:Receptors, Histamine H3; D013844:Thiazoles; D001554:Benzene