Cell-fusion-mediated somatic-cell reprogramming: a mechanism for tissue regeneration.
Spontaneous cell fusion between two cells of different lineages will originate new hybrid cells that have different features from the original parent cells. It has been shown that injury to a tissue can enhance spontaneous cell-cell fusion events. If one of the parent cells of a cell-cell fusion is highly plastic, such as a stem cell, and the other is a somatic cell, their fusion can be followed by reprogramming events that can generate new hybrid pluripotent cells. These, in turn, have the potential to differentiate and regenerate the damaged tissue. However, if this process is deregulated, this would provide a mechanism for cancer development.
Lluis
Frederic
F
Telethon Institute of Genetics and Medicine and Institute of Genetics and Biophysics, CNR, Naples, Italy.
Cosma
Maria Pia
MP
D000818:Animals; D002459:Cell Fusion; D019070:Cell Lineage; D049109:Cell Proliferation; D054338:Cell Transdifferentiation / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D006822:Hybrid Cells; D014411:Neoplastic Stem Cells / Q000473:pathology; D012038:Regeneration / Q000235:genetics; D013234:Stem Cells