title: Coagulopathy in critically ill patients: part 2-soluble clotting factors and hemostatic testing.
abstract: This manuscript provides an overview of how to interpret in vitro clotting studies and how to select studies to evaluate patients with bleeding disorders in the ICU. It provides a practical approach to understanding the complex subject of clotting factor abnormalities, including the most common problems of preanalytical error and anticoagulation therapy. Limitations and pitfalls of diagnostic testing are highlighted.
authors.affiliation: Medical Intensive Care Unit, Division of Allergy, Pulmonary, and Critical Care Medicine, T-1210 MCN Vanderbilt Medical Center, Nashville, TN 37232-2650, USA. art.wheeler@vanderbilt.edu
authors.forename: Arthur P
authors.initials: AP
authors.lastname: Wheeler
authors.forename: Todd W
authors.initials: TW
authors.lastname: Rice
mesh_terms: D001778:Blood Coagulation Disorders / Q000097:blood* / Q000150:complications; D001780:Blood Coagulation Tests / Q000379:methods*; D016638:Critical Illness; D006470:Hemorrhage / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans