title: Intervertebral disc degeneration.
abstract: Disc degeneration in the human spine is a complex phenomenon characterised by biochemical change in the nucleus pulposus and inner annulus and the formation of clefts and fissures radiating from the central area of the disc towards the periphery. In addition, and probably independent of these phenomena, discrete defects in the outer annular attachement are seen which are likely to be due to mechanical stress and failure. The presence of stress tears in disc tissue and their failure to heal can initiate or accelerate the degeneration of the central component of the intervertebral disc. We postulate that discogenic pain may be linked to damage to the outer portion of the annulus fibrosus. Although it would seem logical to assume that discs with sustained high intradiscal pressure would be more prone to pain referred in the outer annular layers because of higher tensile strain, analysis of prospective studies has failed to confirm a relationship between typical pain reproduction at discography and high pressure values. It is concluded that, at present, the only consistent morphological changes present in patients with pain reproduction at discography are the presence of various annular defects involving the outer layers. Whether nerve ingrowth during attempts at repair of these defects is a consistent feature remains to be established.
authors.affiliation: Spinal Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
authors.forename: R D
authors.initials: RD
authors.lastname: Fraser
authors.forename: O L
authors.initials: OL
authors.lastname: Osti
authors.forename: B
authors.initials: B
authors.lastname: Vernon-Roberts
mesh_terms: D000818:Animals; D006801:Humans; D007403:Intervertebral Disc / Q000000981:diagnostic imaging* / Q000473:pathology; D055959:Intervertebral Disc Degeneration / Q000150:complications / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D010146:Pain / Q000209:etiology; D011859:Radiography