title: Recent advances in synthetic bioelastomers.
abstract: This article reviews the degradability of chemically synthesized bioelastomers, mainly designed for soft tissue repair. These bioelastomers involve biodegradable polyurethanes, polyphosphazenes, linear and crosslinked poly(ether/ester)s, poly(epsilon-caprolactone) copolymers, poly(1,3-trimethylene carbonate) and their copolymers, poly(polyol sebacate)s, poly(diol-citrates) and poly(ester amide)s. The in vitro and in vivo degradation mechanisms and impact factors influencing degradation behaviors are discussed. In addition, the molecular designs, synthesis methods, structure properties, mechanical properties, biocompatibility and potential applications of these bioelastomers were also presented.
authors.affiliation: Laboratory of Bone Tissue Engineering of Beijing Research Institute of Traumatology and Orthopaedics, Beijing 100035, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Shi
authors.affiliation: Laboratory of Bone Tissue Engineering of Beijing Research Institute of Traumatology and Orthopaedics, Beijing 100035, China.
authors.forename: Dafu
authors.initials: D
authors.lastname: Chen
authors.affiliation: Beijing Key Laboratory on Preparation and Processing of Novel Polymer Materials at Beijing University of Chemical Technology, 100029, China.
authors.forename: Quanyong
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Beijing Key Laboratory on Preparation and Processing of Novel Polymer Materials at Beijing University of Chemical Technology, 100029, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Spine Surgery of Beijing JiShuiTan Hospital, the Fourth Clinical Medical College of Peking University, Beijing 100035, China.
authors.forename: Xiaochuan
authors.initials: X
authors.lastname: Xu
authors.affiliation: Beijing Key Laboratory on Preparation and Processing of Novel Polymer Materials at Beijing University of Chemical Technology, 100029, China.
authors.forename: Liqun
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Laboratory of Bone Tissue Engineering of Beijing Research Institute of Traumatology and Orthopaedics, Beijing 100035, China.|Department of Spine Surgery of Beijing JiShuiTan Hospital, the Fourth Clinical Medical College of Peking University, Beijing 100035, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Tian
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D054813:Polyhydroxyalkanoates / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D009943:Organophosphorus Compounds; D011091:Polyesters; D054813:Polyhydroxyalkanoates; D011108:Polymers; D011140:Polyurethanes; C108974:poly(phosphazene); C016240:polycaprolactone