title: Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients.
abstract: The role of the Smac/DIABLO protein, a novel apoptosis agonist, in acute myeloid leukemia (AML) is not clearly determined. The expression of Smac/DIABLO protein in AML leukemic cells and its relationship with clinical outcome was evaluated in this study. The intracellular expression of Smac/DIABLO protein was assessed using multi-color flow cytometry in 71 newly diagnosed AML patients treated with conventional chemotherapy. It was found that the high expression of Smac/DIABLO protein was an independent prognostic factor in terms of higher complete remission rate (p<0.001) and longer overall survival (p=0.003). Moreover the low expression of Smac/DIABLO protein was associated with poor karyotype.
authors.affiliation: Department of Hematology, Medical University of Lodz, Copernicus Memorial Hospital, Ciolkowskiego 2 str, 93-510 Lodz, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Pluta
authors.forename: Agata
authors.initials: A
authors.lastname: Wrzesien-Kus
authors.forename: Barbara
authors.initials: B
authors.lastname: Cebula-Obrzut
authors.forename: Anna
authors.initials: A
authors.lastname: Wolska
authors.forename: Anna
authors.initials: A
authors.lastname: Szmigielska-Kaplon
authors.forename: Magdalena
authors.initials: M
authors.lastname: Czemerska
authors.forename: Piotr
authors.initials: P
authors.lastname: Pluta
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Robak
authors.forename: Piotr
authors.initials: P
authors.lastname: Smolewski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wierzbowska
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D051017:Apoptosis Regulatory Proteins; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000032:analysis* / Q000235:genetics; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000378:metabolism / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000032:analysis* / Q000235:genetics; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D051017:Apoptosis Regulatory Proteins; C412403:DIABLO protein, human; D047908:Intracellular Signaling Peptides and Proteins; D024101:Mitochondrial Proteins