title: Construction of all-carbon quaternary center by R2AlCl-mediated ring-opening reaction of oxacycles.
abstract: An unexpected R(2)AlCl-mediated ring-opening reaction of oxacycles for the formation of all-carbon quaternary centers was discovered, and a possible mechanism is proposed. The developed chemistry provides a concise approach to synthesize structural diverse of dolastane-type compounds.
authors.affiliation: Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Che
authors.forename: Lianzhu
authors.initials: L
authors.lastname: Liu
authors.forename: Jianxian
authors.initials: J
authors.lastname: Gong
authors.forename: Yunfang
authors.initials: Y
authors.lastname: Yang
authors.forename: Guoxin
authors.initials: G
authors.lastname: Wang
authors.forename: Junmin
authors.initials: J
authors.lastname: Quan
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D004224:Diterpenes