Patient preference and acceptability of calcium plus vitamin D3 supplementation: a randomised, open, cross-over trial.
Preference for a drug formulation is important in adherence to long-term medication for chronic illnesses such as osteoporosis. We investigated the preference for and acceptability of chewable tablet containing calcium and vitamin D (Calci Chew D(3), Nycomed) compared to that of a sachet containing calcium and vitamin D(3) (Cad, Will-Pharma). This open, randomised, cross-over trial was set up to compare the preference and acceptability of two calcium plus vitamin D(3) formulations (both with 500 mg calcium and 400/440 IU vitamin D3), given twice a day in patients with osteoporosis. Preference and acceptability were assessed by means of questionnaires. Preference was determined by asking the question, which treatment the patient preferred, and acceptability was measured by scoring five variables, using rating scales. Of the 102 patients indicating a preference for a trial medication, 67% preferred the chewable tablet, 19% the sachet with calcium and vitamin D(3,) and 15% stated no preference. The significant preference for Calci Chew D(3) (p < 0.0001) was associated with higher scores for all five acceptability variables. The two formulations were tolerated equally well. A significant greater number of patients considered the chewable tablet as preferable and acceptable to the sachet, containing calcium and vitamin D(3).


BACKGROUND
Current Controlled Trials ISRCTN18822358.
den Uyl
Debby
D
Department of Rheumatology, VU Medical Centre, Room 3A58, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands.
Geusens
Piet P M M
PP
van Berkum
Frank N R
FN
Houben
Harry H M L
HH
Jebbink
Max C
MC
Lems
Willem F
WF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002118:Calcium / Q000378:metabolism; D002762:Cholecalciferol / Q000009:adverse effects / Q000627:therapeutic use*; D018592:Cross-Over Studies; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D010024:Osteoporosis / Q000188:drug therapy*; D057240:Patient Preference; D011795:Surveys and Questionnaires
D002762:Cholecalciferol; D002118:Calcium