A neural mass model to simulate different rhythms in a cortical region.
An original neural mass model of a cortical region has been used to investigate the origin of EEG rhythms. The model consists of four interconnected neural populations: pyramidal cells, excitatory interneurons and inhibitory interneurons with slow and fast synaptic kinetics, GABA(A, slow) and GABA(A,fast) respectively. A new aspect, not present in previous versions, consists in the inclusion of a self-loop among GABA(A,fast) interneurons. The connectivity parameters among neural populations have been changed in order to reproduce different EEG rhythms. Moreover, two cortical regions have been connected by using different typologies of long range connections. Results show that the model of a single cortical region is able to simulate the occurrence of multiple power spectral density (PSD) peaks; in particular the new inhibitory loop seems to have a critical role in the activation in gamma (gamma) band, in agreement with experimental studies. Moreover the effect of different kinds of connections between two regions has been investigated, suggesting that long range connections toward GABA(A,fast) interneurons have a major impact than connections toward pyramidal cells. The model can be of value to gain a deeper insight into mechanisms involved in the generation of gamma rhythms and to provide better understanding of cortical EEG spectra.
Zavaglia
M
M
Department of Electronics, Computer Science, and Systems, University of Bologna, Cesena, Italy. melissa.zavaglia@unibo.it
Cona
F
F
Ursino
M
M
D002540:Cerebral Cortex / Q000502:physiology*; D003198:Computer Simulation; D004569:Electroencephalography; D006801:Humans; D007395:Interneurons / Q000502:physiology*; D007700:Kinetics; D008564:Membrane Potentials / Q000502:physiology; D008959:Models, Neurological; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology*; D011963:Receptors, GABA-A / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology
D011963:Receptors, GABA-A