title: Increased serum YKL-40 and C-reactive protein levels are associated with angiographic lesion progression in patients with coronary artery disease.
abstract: OBJECTIVE
  YKL-40 is a pro-inflammatory protein highly expressed in atherosclerotic plaques, and is related to prognosis of patients with coronary artery disease (CAD). This study aimed to assess the possible association between YKL-40 and coronary lesion progression in CAD patients.
  
  
  METHODS
  A total of 313 patients with CAD, who underwent percutaneous coronary intervention (PCI) and follow-up angiography (mean 13.2+/-3.2 months) were recruited. Serum YKL-40 and high-sensitivity C-reactive protein (hsCRP) levels were measured using ELISA kits.
  
  
  RESULTS
  Baseline serum YKL-40 and hsCRP levels were higher in those with lesion progression (all p<0.001 vs. patients without lesion progression), and correlated significantly with change of lumen diameter stenosis and cumulative coronary obstruction score (all p<0.01). Multivariable logistic regression analysis revealed that after adjusting for conventional risk factors, number of total coronary artery lesions, YKL-40 and hsCRP levels were independent determinants of lesion progression. An area under the curve of YKL-40 and hsCRP was 0.744 (CI 95% 0.685-0.804, p<0.001) and 0.716 (CI 95% 0.657-0.776, p<0.001), respectively. The optimal values of cut-off point were 74.98 ng/ml (sensitivity 70%, specificity 71%) for YKL-40 and 3.21 mg/l (sensitivity 66%, specificity 68%) for hsCRP to predict lesion progression.
  
  
  CONCLUSIONS
  Increased serum YKL-40 and hsCRP levels are independently associated with lesion progression in patients with CAD.
authors.affiliation: Department of Cardiology, Rui Jin Hospital, Jiaotong University School of Medicine, Shanghai 200025, PR China.
authors.forename: Jian Lei
authors.initials: JL
authors.lastname: Zheng
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.forename: Jian
authors.initials: J
authors.lastname: Hu
authors.forename: Rui Yan
authors.initials: RY
authors.lastname: Zhang
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Qiu Jin
authors.initials: QJ
authors.lastname: Chen
authors.forename: Wei Feng
authors.initials: WF
authors.lastname: Shen
mesh_terms: D054392:Adipokines; D000368:Aged; D000792:Angiography / Q000379:methods*; D015906:Angioplasty, Balloon, Coronary; D002097:C-Reactive Protein / Q000096:biosynthesis*; D000071451:Chitinase-3-Like Protein 1; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000473:pathology; D018450:Disease Progression; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007249:Inflammation; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors
chemical_list: D054392:Adipokines; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D006023:Glycoproteins; D037102:Lectins; D002097:C-Reactive Protein