title: Unusual reactions to 5-HT3 receptor antagonists in a child with rhabdomyosarcoma.
abstract: A case of unusual reactions consisting of involuntary abnormal facial movements in a child following exposure to the 5-HT3 receptor antagonists for prophylaxis against chemotherapy-induced vomiting is presented. Potential mechanisms for these reactions are discussed.
authors.affiliation: Division of Clinical Pharmacology & Toxicology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Candace Y W
authors.initials: CY
authors.lastname: Lee
authors.forename: Savithiri
authors.initials: S
authors.lastname: Ratnapalan
authors.forename: Margaret
authors.initials: M
authors.lastname: Thompson
authors.forename: Paul C
authors.initials: PC
authors.lastname: Nathan
authors.forename: Jordan
authors.initials: J
authors.lastname: Closs
authors.forename: Amy
authors.initials: A
authors.lastname: French
authors.forename: Angela
authors.initials: A
authors.lastname: Punnett
authors.forename: Facundo
authors.initials: F
authors.lastname: Garcia-Bournissen
authors.forename: Shinya
authors.initials: S
authors.lastname: Ito
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
mesh_terms: D000932:Antiemetics / Q000009:adverse effects / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D005152:Facial Muscles / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008297:Male; D017294:Ondansetron / Q000009:adverse effects* / Q000627:therapeutic use; D012208:Rhabdomyosarcoma / Q000188:drug therapy; D058831:Serotonin 5-HT3 Receptor Antagonists; D012702:Serotonin Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents; D058831:Serotonin 5-HT3 Receptor Antagonists; D012702:Serotonin Antagonists; D017294:Ondansetron