[Anti-Helicobacter pylori treatment in patients with idiopathic thrombocytopenic purpura].
OBJECTIVE
To observe the effect of anti-Helicobacter pylori (H.pylori) treatment on patients with idiopathic thrombocytopenic purpura (ITP) and its effect on blood platelet.


METHODS
From April 2006 to April 2008, a total of 31 patients diagnosed as having ITP and H. pylori infection were collected. These patients were given standard antibiotic therapy for H. pylori eradication (omeprazole 20 mg, clarithromycin 0.5 g, and amoxicillin 1.0 g, twice per day for 1 week). The effect of anti-H. pylori treatment was analyzed, and the blood platelets were counted before the treatment and on day 7, 14, and 28 after the treatment.


RESULTS
Of the 31 ITP patients with H. pylori infection, 21 were cured and 10 were not effective, with the effective rate 67.74%. Blood platelet increased in the cured group but did not change in the no-effect group.


CONCLUSIONS
Anti-H. pylori treatment could increase the blood platelet, and H. pylori infection may be related to the reduction of blood platelet in ITP patients.
Wu
Siyun
S
Department of Clinic Laboratory Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Li
Yanming
Y
Jian
Zijuan
Z
Tang
Faqing
F
D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D017291:Clarithromycin / Q000008:administration & dosage; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000188:drug therapy*; D012189:Retrospective Studies; D055815:Young Adult
D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole