Computational analysis identifies human adenovirus type 55 as a re-emergent acute respiratory disease pathogen.
Novel human adenoviruses (HAdVs) arise from genome recombination. Analysis of HAdV type 55 from an outbreak in China shows a hexon recombination between HAdV-B11 and HAdV-B14, resulting in a genome that is 97.4% HAdV-B14. Sporadic appearances as a re-emergent pathogen and misidentification as "HAdV-B11a" are due to this partial hexon.
Walsh
Michael P
MP
Department of Bioinformatics and Computational Biology, George Mason University, 10900 University Blvd., MSN 5B3, Manassas, Virginia 20110, USA.
Seto
Jason
J
Jones
Morris S
MS
Chodosh
James
J
Xu
Wenbo
W
Seto
Donald
D
D000258:Adenovirus Infections, Human / Q000453:epidemiology* / Q000821:virology; D000260:Adenoviruses, Human / Q000235:genetics* / Q000302:isolation & purification*; D036022:Capsid Proteins / Q000235:genetics; D002681:China / Q000453:epidemiology; D021821:Communicable Diseases, Emerging / Q000453:epidemiology* / Q000821:virology; D019295:Computational Biology; D004279:DNA, Viral / Q000235:genetics; D004196:Disease Outbreaks; D019143:Evolution, Molecular; D006801:Humans; D011995:Recombination, Genetic; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000821:virology
D036022:Capsid Proteins; D004279:DNA, Viral; C018315:hexon capsid protein, Adenovirus