Vibralactones D-F from cultures of the basidiomycete Boreostereum vibrans.
Three new metabolites, vibralactones D-F (1-3) were isolated from cultures of the basidiomycete Boreostereum vibrans. The relative configuration of 1 was established on the basis of X-ray diffraction analysis, while the absolute configurations of 1-3 were assigned using a modified Mosher's method. Compound 1 showed weak inhibitory activities against isozymes of 11beta-hydroxysteroid dehydrogenases (HSD) with IC(50) values of 85.7 microM (human HSD1), 295.2 microM (mouse HSD1), and 87.1 microM (human HSD2).
Jiang
Meng-Yuan
MY
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
Zhang
Ling
L
Dong
Ze-Jun
ZJ
Yang
Zhu-Liang
ZL
Leng
Ying
Y
Liu
Ji-Kai
JK
D042842:11-beta-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D002460:Cell Line; D018360:Crystallography, X-Ray; D006801:Humans; D007783:Lactones / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008958:Models, Molecular; D014162:Transfection
D007783:Lactones; C522315:vibralactone; D042842:11-beta-Hydroxysteroid Dehydrogenases