title: Generalized spike-wave discharges involve a default mode network in patients with juvenile absence epilepsy: a MEG study.
abstract: This study uses magnetoencephalography (MEG) to examine whether cortical regions that constitute a default mode network are involved during generalized spike-wave discharges (GSWs) in patients with juvenile absence epilepsy (JAE). We studied five JAE patients for whom MEG was recorded using a 204-channel, whole-head gradiometer system. Dynamic statistical parametric mapping (dSPM) was done to estimate the cortical source distribution of GSW. The dSPM results showed strong medial prefrontal activation in all patients, with activation in the posterior cingulate and precuneus in three of five patients simultaneously or slightly after medial prefrontal activation. Furthermore, dSPM showed that the initial activation of a GSW appears in the focal cortical regions. Cortical regions that constitute a default mode network are strongly involved in the GSW process in some patients with JAE. Results also show that focal cortical activation appears at the onset of a GSW.
authors.affiliation: Department of Psychiatry and Neurology, Hokkaido University School of Medicine, North 15, West 7, Sapporo 060-8638, Japan. kootaroo@ab.auone-net.jp
authors.forename: Kotaro
authors.initials: K
authors.lastname: Sakurai
authors.forename: Youji
authors.initials: Y
authors.lastname: Takeda
authors.forename: Naoaki
authors.initials: N
authors.lastname: Tanaka
authors.forename: Tsugiko
authors.initials: T
authors.lastname: Kurita
authors.forename: Hideaki
authors.initials: H
authors.lastname: Shiraishi
authors.forename: Fumiya
authors.initials: F
authors.lastname: Takeuchi
authors.forename: Shingo
authors.initials: S
authors.lastname: Nakane
authors.forename: Keitaro
authors.initials: K
authors.lastname: Sueda
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Koyama
mesh_terms: D000200:Action Potentials; D000328:Adult; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000503:physiopathology*; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography / Q000379:methods; D008297:Male; D017397:Prefrontal Cortex / Q000503:physiopathology