Serum antimullerian hormone (AMH) levels are elevated in adolescent girls with polycystic ovaries and the polycystic ovarian syndrome (PCOS).
Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in adolescents, with potentially significant lifelong consequences. This prospective study set out to determine if the investigators could derive a threshold value of antimullerian hormone (AMH) that would predict its presence according to two internationally recognized definitions using a simple measurement, avoiding more extensive and potentially more invasive investigations. The study failed to demonstrate, in a general adolescent population, that serum AMH is a reliable predictor of PCO morphology or for the presence of PCOS.
Hart
Roger
R
School of Women's and Infants' Health, University of Western Australia, and Women and Infants Research Foundation, King Edward Memorial Hospital, Perth, Western Australia, Australia. roger.hart@uwa.edu.au
Doherty
Dorota A
DA
Norman
Robert J
RJ
Franks
Stephen
S
Dickinson
Jan E
JE
Hickey
Martha
M
Sloboda
Deborah M
DM
D000293:Adolescent; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D015331:Cohort Studies; D003940:Diagnostic Techniques, Endocrine; D005260:Female; D006801:Humans; D009929:Organ Size; D010048:Ovarian Cysts / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D010053:Ovary / Q000473:pathology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D012680:Sensitivity and Specificity; D015854:Up-Regulation
D015415:Biomarkers; D054304:Anti-Mullerian Hormone