Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma.
We have used copy number variation (CNV) analysis with SNP mapping arrays for miRNA-15a and miRNA-16-1 expression analysis in patients with multiple myeloma (MM) with or without deletion of chromosome 13q14. MiRNA-15a and miRNA-16 display a range of expression patterns in MM patients, independent of the chromosome 13 status. These findings suggest that genes other than miR-15a and miR-16 may explain the prognostic significance of 13q14 deletions.
Corthals
Sophie L
SL
Department of Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands.
Jongen-Lavrencic
Mojca
M
de Knegt
Yvonne
Y
Peeters
Justine K
JK
Beverloo
H Berna
HB
Lokhorst
Henk M
HM
Sonneveld
Pieter
P
D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D017353:Gene Deletion; D018628:Gene Dosage; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D035683:MicroRNAs / Q000235:genetics*; D009101:Multiple Myeloma / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
C505362:MIRN16 microRNA, human; D035683:MicroRNAs