Titanocene difluorides with improved cytotoxic activity.
Titanocene difluorides can be obtained by halide metathesis of the respective titanocene dichlorides with trimethyltin fluoride (Me(3)SnF), giving access to a new class of cytotoxic active substances. Furthermore, an improved method for the synthesis of diaryl-substituted titanocene dichlorides is presented.
Eger
Silvia
S
Fachbereich Chemie and Konstanz Research School Chemical Biology, Universität Konstanz, Germany.
Immel
Timo A
TA
Claffey
James
J
Müller-Bunz
Helge
H
Tacke
Matthias
M
Groth
Ulrich
U
Huhn
Thomas
T
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D019008:Drug Resistance, Neoplasm / Q000187:drug effects / Q000235:genetics; D004354:Drug Screening Assays, Antitumor; D004357:Drug Synergism; D020128:Inhibitory Concentration 50; D007680:Kidney Neoplasms / Q000188:drug therapy; D018374:LLC-PK1 Cells; D008297:Male; D051379:Mice; D008819:Mice, Nude; D015394:Molecular Structure; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D011471:Prostatic Neoplasms / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2; D013329:Structure-Activity Relationship; D013552:Swine
D009942:Organometallic Compounds; D019253:Proto-Oncogene Proteins c-bcl-2; C406884:titanocene; C020528:titanocene dichloride