title: Efficient anisotropic filtering of diffusion tensor images.
abstract: To improve the accuracy of structural and architectural characterization of living tissue with diffusion tensor imaging, an efficient smoothing algorithm is presented for reducing noise in diffusion tensor images. The algorithm is based on anisotropic diffusion filtering, which allows both image detail preservation and noise reduction. However, traditional numerical schemes for anisotropic filtering have the drawback of inefficiency and inaccuracy due to their poor stability and first order time accuracy. To address this, an unconditionally stable and second order time accuracy semi-implicit Craig-Sneyd scheme is adapted in our anisotropic filtering. By using large step size, unconditional stability allows this scheme to take much fewer iterations and thus less computation time than the explicit scheme to achieve a certain degree of smoothing. Second-order time accuracy makes the algorithm reduce noise more effectively than a first order scheme with the same total iteration time. Both the efficiency and effectiveness are quantitatively evaluated based on synthetic and in vivo human brain diffusion tensor images, and these tests demonstrate that our algorithm is an efficient and effective tool for denoising diffusion tensor images.
authors.affiliation: Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232, USA.
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu
authors.forename: Adam W
authors.initials: AW
authors.lastname: Anderson
authors.forename: John C
authors.initials: JC
authors.lastname: Gore
authors.forename: Zhaohua
authors.initials: Z
authors.lastname: Ding
mesh_terms: D000465:Algorithms; D016880:Anisotropy; D001921:Brain / Q000033:anatomy & histology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted