FGFR3 expression in Xenopus laevis.
We studied the expression of FGF receptor 3 (FGFR3) mRNA throughout early development of Xenopus laevis by RT-PCR and in situ hybridization. RT-PCR shows that FGFR3 mRNA is localized within the gastrula; regionalized staining is detected by the neural plate stage and continues throughout embryonic development. Strong expression is seen in developing neural structures, especially in the forebrain and hindbrain, including the developing eyes, and in lateral mesoderm. Comparison of these data with previous reports of FGF expression in this species suggests possible FGF-FGFR3 interactions. The pattern of FGFR3 expression appears to be strongly conserved among vertebrate embryos.
Pope
Amanda Popielski
AP
Department of Biology, Ithaca College, Ithaca, NY 14850, USA.
Liu
Chen
C
Sater
Amy K
AK
Servetnick
Marc
M
D000818:Animals; D005775:Gastrula / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D016548:Prosencephalon / Q000196:embryology / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000096:biosynthesis / Q000235:genetics*; D012249:Rhombencephalon / Q000196:embryology / Q000378:metabolism; D014982:Xenopus laevis / Q000196:embryology
D012333:RNA, Messenger; D051498:Receptor, Fibroblast Growth Factor, Type 3