title: Seroprevalence of human immunodeficiency virus in Nepalese blood donors: A study from three regional blood transfusion services.
abstract: OBJECTIVE
  The likelihood of human immunodeficiency virus (HIV) infection occurring in recipients of HIV seropositive blood is close to 100%. Transmission during window period is still possible even each unit of blood is tested for anti-HIV 1 and 2 antibodies. The possibility of window period transmission would be minimized if blood is collected from low risk targeted general public. A continuous surveillance data might prove valuable for concerned authorities to assess their service and plan for further improvements in transfusion safety. Our aim was to determine the seroprevalence of HIV in regional blood transfusion services located at three developmental regions of Nepal and compare the results.
  
  
  METHODS
  A total of 16,557 blood donors were screened for anti-HIV 1 and 2 antibodies in three blood transfusion services viz. 5,351 donors in Morang, 5,211 in Banke, 5,995 in Kaski by using rapid anti HIV 1 and 2 Test. The statistical significance of difference in seroprevalence was tested by Fisher's Exact Test using the statistical software 'Winpepi ver 3.8'.
  
  
  RESULTS
  The overall seroprevalence of HIV among blood donors in the regional blood transfusion services was 0.054% (9/16557) and 100% seropositivity was among male donors. The individual seroprevalence in Morang was 0.019%, in Banke was 0.095% and in Kaski was 0.05%. The HIV seroprevalence was not significantly different in regional blood transfusion services of Nepal (Fisher Exact Test, P = 0.2096).
  
  
  CONCLUSIONS
  The seroprevalence in the regional blood transfusion service of Nepal was quite low and the seroprevalence rate was not significantly different.
authors.forename: Bishnu Raj
authors.initials: BR
authors.lastname: Tiwari
authors.forename: Prakash
authors.initials: P
authors.lastname: Ghimire
authors.forename: Surendra
authors.initials: S
authors.lastname: Karki
authors.forename: Manita
authors.initials: M
authors.lastname: Rajkarnikar