title: Crosstalk between perivascular adipose tissue and blood vessels.
abstract: Crosstalk between cells in the blood vessel wall is vital to normal vascular function and is perturbed in diseases such as atherosclerosis and hypertension. Perivascular adipocytes reside at the adventitial border of blood vessels but until recently were virtually ignored in studies of vascular function. However, perivascular adipocytes have been demonstrated to be powerful endocrine cells capable of responding to metabolic cues and transducing signals to adjacent blood vessels. Accordingly, crosstalk between perivascular adipose tissue (PVAT) and blood vessels is now being intensely examined. Emerging evidence suggests that PVAT regulates vascular function through numerous mechanisms, but evidence to date suggests modulation of three key aspects that are the focus of this review: inflammation, vasoreactivity, and smooth muscle cell proliferation.
authors.affiliation: Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Rajsheker
authors.forename: David
authors.initials: D
authors.lastname: Manka
authors.forename: Andra L
authors.initials: AL
authors.lastname: Blomkalns
authors.forename: Tapan K
authors.initials: TK
authors.lastname: Chatterjee
authors.forename: Lynn L
authors.initials: LL
authors.lastname: Stoll
authors.forename: Neal L
authors.initials: NL
authors.lastname: Weintraub
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D001808:Blood Vessels / Q000378:metabolism* / Q000502:physiology; D049109:Cell Proliferation; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology; D008954:Models, Biological; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology