title: Successful unrelated bone marrow transplantation for a human immunodeficiency virus type-1-seropositive acute myelogenous leukemia patient following HAART.
abstract: The availability of highly active anti-retroviral therapy (HAART) has greatly improved the outcome of human immunodeficiency virus type-1 (HIV-1) infection and disease. We report here on a case of an HIV-1-seropositive patient with acute myelogenous leukemia who underwent a successful allogeneic unrelated bone marrow transplantation following HAART. A 40-year-old Japanese HIV-seropositive man underwent allogeneic unrelated bone marrow transplantation using a myeloablative pretransplant-conditioning regimen. Neutrophil engraftment occurred on day +18, and donor chimerism was achieved on day +27. During pre- and post- transplantation, the HAART was not interrupted. Over 1 year after transplantation, the patient is alive and in continuous complete remission with undetectable levels of HIV-1 RNA. HAART can lead to a successful hematopoietic stem cell transplantation without severe opportunistic infections.
authors.affiliation: Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8606, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Oka
authors.forename: Haruko
authors.initials: H
authors.lastname: Tashiro
authors.forename: Mitsuho
authors.initials: M
authors.lastname: Mizutani-Noguchi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Koga
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Sugao
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Shirasaki
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Miura
authors.forename: Nobu
authors.initials: N
authors.lastname: Akiyama
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kawasugi
authors.forename: Shin
authors.initials: S
authors.lastname: Fujimori
authors.forename: Naoki
authors.initials: N
authors.lastname: Shirafuji
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D016026:Bone Marrow Transplantation; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000628:therapy*; D008297:Male; D012367:RNA, Viral; D012074:Remission Induction
chemical_list: D012367:RNA, Viral