title: Changes in waist circumference and body mass index in relation to changes in serum uric acid in Japanese individuals.
abstract: OBJECTIVE
  Studies have shown that obesity is associated with an increase in serum uric acid; and few data are available on the relationship between changes in measures of obesity and changes in uric acid concentrations. We investigated the relationship among percentage changes in waist circumference (%dWC), body mass index (%dBMI), and serum uric acid (%dUA).
  
  
  METHODS
  The data of 3153 individuals [1968 men, 1185 women (536 premenopausal, 649 postmenopausal)] who underwent general health screening over a 2-year period and were not taking antihyperuricemic medication were analyzed.
  
  
  RESULTS
  Stepwise multiple regression analysis showed that %dBMI was associated positively with %dUA in postmenopausal women and men, and the association retained statistical significance after adjustment for changes in blood pressure and in renal function. Association between %dBMI and %dUA was not significant in premenopausal women. In men, %dWC was a predicting factor for %dUA, although it did not remain significant when %dBMI was used as a covariate in the statistical model. Multivariate logistic regression analysis showed that the odds ratio of the association between the lowest %dBMI quartile (%dBMI < -1.86) and the lowest %dUA quartile (%dUA < -7.41) was 2.04 (95% CI 1.35-3.07) in postmenopausal women and 1.46 (95% CI 1.14-1.86) in men.
  
  
  CONCLUSIONS
  Weight loss may represent an effective nonmedical strategy for reducing serum UA levels, especially in postmenopausal women and men.
authors.affiliation: Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan. nobuishizka-tky@umin.ac.jp
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Ishizaka
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ishizaka
authors.forename: Akiko
authors.initials: A
authors.lastname: Toda
authors.forename: Mizuki
authors.initials: M
authors.lastname: Tani
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Koike
authors.forename: Minoru
authors.initials: M
authors.lastname: Yamakado
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
mesh_terms: D044466:Asian People; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007564:Japan; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood; D016017:Odds Ratio; D018579:Patient Selection; D012044:Regression Analysis; D011795:Surveys and Questionnaires; D014527:Uric Acid / Q000097:blood*; D055105:Waist Circumference / Q000502:physiology*
chemical_list: D008055:Lipids; D014527:Uric Acid