title: A 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight change.
abstract: OBJECTIVE
  Adiponectin gene variations have been associated with obesity. There are few interventional studies analyzing this association. The aim of this study was to analyze the effects of a nutritional intervention with Mediterranean-style diet and three (-4034A/C, +45T/G, and +276 G/T) adiponectin gene variants on 3-year body weight changes in high cardiovascular risk patients.
  
  
  METHODS
  A total of 737 participants, aged 55-80 at high cardiovascular risk were assigned to a low-fat diet or to a Mediterranean-style diet (MD) groups, one with high intake of virgin olive oil (VOO) and the other with high intake of nuts. Anthropometric parameters were taken at baseline and after 3-year follow-up, and the genotyping of the -4034A/C, +45T/G, and +276 G/T polymorphisms was done.
  
  
  RESULTS
  GG genotype of the +45T/G polymorphism was associated with 3-year higher body weight gain (B = 1.399; B = 0.043). TT genotype of the +276G/T polymorphism was linked to the highest 3-year body weight gain in men. Both Mediterranean diets appeared to reverse this effect (p for interaction = 0.053).
  
  
  CONCLUSIONS
  Adiponectin gene variation appeared to be associated with 3-year body weight changes in a high cardiovascular risk population. This association may be modulated by a nutritional intervention with a Mediterranean-style diet.
authors.affiliation: Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Irunlarrea 1, 31080, Pamplona, Navarra, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Razquin
authors.forename: J A
authors.initials: JA
authors.lastname: Martínez
authors.forename: M A
authors.initials: MA
authors.lastname: Martínez-González
authors.forename: J
authors.initials: J
authors.lastname: Salas-Salvadó
authors.forename: R
authors.initials: R
authors.lastname: Estruch
authors.forename: A
authors.initials: A
authors.lastname: Marti
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000368:Aged; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000235:genetics / Q000517:prevention & control; D003920:Diabetes Mellitus / Q000503:physiopathology; D018752:Diet, Fat-Restricted; D038441:Diet, Mediterranean; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D000069463:Olive Oil; D010938:Plant Oils; D011110:Polymorphism, Genetic; D012307:Risk Factors; D015430:Weight Gain / Q000235:genetics* / Q000502:physiology*
chemical_list: D052242:Adiponectin; D000069463:Olive Oil; D010938:Plant Oils