Self-assembled lipid nanomedicines for siRNA tumor targeting.
Lipid-based nanoparticle technology has developed from chemical drug carrier into an efficient multifunctional siRNA tumor targeting delivery system. In this review, we start with an overview of the lipid-based nanomedicine history and the two classes of lipidic vectors for DNA or siRNA delivery. Then we discuss the features of lipid-based nanomedicine that lead to effective tumor targeting and the principles behind. We also discuss nanoparticle surface modification, classes of tumor targeting ligands, and other state-of-the-art strategies for enhancing endosome release primarily focused on lipid-based systems. At the end, we show that multifunctional self-assembled lipid-based nanoparticles could also be versatile delivery vehicles for cancer molecular imaging probes.
Tseng
Yu-Cheng
YC
Division of Molecular Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
Huang
Leaf
L
D000818:Animals; D003460:Crystallization / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods*; D018390:Gene Targeting / Q000379:methods*; D006801:Humans; D050997:Nanomedicine / Q000639:trends; D053758:Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D034741:RNA, Small Interfering / Q000235:genetics* / Q000627:therapeutic use*; D014162:Transfection / Q000379:methods*
D034741:RNA, Small Interfering