Paralemnolins J-P, new sesquiterpenoids from the soft coral Paralemnalia thyrsoide.
Six new sesquiterpenoids, paralemnolins J-O (1-6), along with one novel norsesquiterpenoid, paralemnolin P (7), have been isolated from the soft coral Paralemnalia thyrsoides. The structures of metabolites 1-7 were established on the basis of extensive NMR study and chemical methods. The structure of 5 was further confirmed by a single-crystal X-ray analysis. Cytotoxicity of these metabolites toward a limited panel of cancer cell lines also is described.
Wang
Guey-Horng
GH
Department of Cosmetic Science, Chia-Nan University of Pharmacy and Science, Taiwan.
Huang
Ho-Cheng
HC
Su
Jui-Hsin
JH
Wu
Yang-Chang
YC
Sheu
Jyh-Horng
JH
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000032:analysis* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C547780:paralemnolin