title: Trypanocidal activity of the ethyl esters of N-propyl and N-isopropyl oxamates on intracellular amastigotes of Trypanosoma cruzi acute infected mice.
abstract: In this investigation we studied the trypanocidal activity of the ethyl esters of N-propyl (Et-NPOX) and N-isopropyl (Et-NIPOX) oxamates on bloodstream trypomastigotes and on the clinically relevant intracellular amastigotes of Trypanosoma cruzi acute infected mice. In the infected and treated mice, the levels of parasitemia were drastically reduced between days 15 and 20 of treatment and almost to zero between days 35 and 40. We also found that Et-NPOX completely eliminated amastigote nests in the myocardium of mice infected with INC-5 or NINOA T. cruzi strain, and in skeletal muscle the reduction in the number of amastigote nests was between 60 and 80% in both strains. Also, Et-NIPOX reduced by 60-80% the number of amastigote nests in the myocardium and skeletal muscle of mice infected with these T. cruzi strains. In contrast, nifurtimox, used for comparison, produced a reduction of amastigote nests of only 20-40% in the studied tissues in both strains.
authors.affiliation: Departamento de Bioquímica, Escuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional, Mexico City, Mexico.
authors.forename: Charmina
authors.initials: C
authors.lastname: Aguirre-Alvarado
authors.forename: Fabiola
authors.initials: F
authors.lastname: Zaragoza-Martínez
authors.forename: Lorena
authors.initials: L
authors.lastname: Rodríguez-Páez
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Téllez-Rendón
authors.forename: Benjamín
authors.initials: B
authors.lastname: Nogueda
authors.forename: Isabel
authors.initials: I
authors.lastname: Baeza
authors.forename: Carlos
authors.initials: C
authors.lastname: Wong
mesh_terms: D000818:Animals; D051379:Mice; D010072:Oxamic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000187:drug effects*; D014352:Trypanosomiasis / Q000188:drug therapy*
chemical_list: D014344:Trypanocidal Agents; D010072:Oxamic Acid