title: Preparation of stable dispersion of barium titanate nanoparticles: Potential applications in biomedicine.
abstract: Nanoscale structures and materials have been explored in many biological applications because of their extraordinary novel properties. Here we propose a study of cellular interactions with barium titanate nanoparticles, an interesting ceramic material that has received a lot of interest in the nanotechnology research, but without any attention about its biological potential. We introduced for the first time an efficient method for the preparation of stable aqueous dispersions of barium titanate nanoparticles, characterized with FIB, TEM and AFM imaging, light scattering, Z-potential and UV/vis analysis. Finally, we presented a systematic study of short-term cytotoxicity of the prepared dispersion based both on quantitative (metabolism, proliferation) and qualitative (apoptosis, viability, differentiation) assays.
authors.affiliation: Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy. g.ciofani@sssup.it
authors.forename: G
authors.initials: G
authors.lastname: Ciofani
authors.forename: S
authors.initials: S
authors.lastname: Danti
authors.forename: S
authors.initials: S
authors.lastname: Moscato
authors.forename: L
authors.initials: L
authors.lastname: Albertazzi
authors.forename: D
authors.initials: D
authors.lastname: D'Alessandro
authors.forename: D
authors.initials: D
authors.lastname: Dinucci
authors.forename: F
authors.initials: F
authors.lastname: Chiellini
authors.forename: M
authors.initials: M
authors.lastname: Petrini
authors.forename: A
authors.initials: A
authors.lastname: Menciassi
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D017609:Barium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D035843:Biomedical Research; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D051381:Rats; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D017609:Barium Compounds; C024547:barium titanate(IV); D014025:Titanium