title: The association of Fcgamma receptor IIIb genetic polymorphism and susceptibility to periodontitis in Taiwanese individuals.
abstract: OBJECTIVE
  The allelic polymorphism of FcgammaRIIIb, the neutrophil-specific receptor involved in the phagocytosis of immunoglobulin G-opsonized bacteria, has functionally distinct capacities that are important in host defence mediated by neutrophils. The aim of this study was to identify whether the polymorphism of FcgammaRIIIb is associated with periodontitis in Taiwanese individuals.
  
  
  METHODS
  This case-control study included of 93 aggressive periodontitis (AgP) patients, 372 chronic periodontitis (CP) patients and 158 healthy controls (HC). The FcgammaRIIIb genotypes were determined by PCR using allele-specific primers. The risk for periodontitis associated with genotypes was calculated as the odds ratio (OR).
  
  
  RESULTS
  A significant difference was observed in the distribution of the FcgammaRIIIb genotype between either AgP and HC, or AgP and CP, but not between CP and HC. The OR for carriage of the NA2 allele (NA1NA2+NA2NA2 versus NA1NA1) in AgP was 3.27 [95% confidence interval (CI)=1.57-7.51, p=0.0027] and 2.94 (95% CI=1.49-6.48, p=0.0037), as compared with HC and CP. After adjusting for possible confounding factors, the association was still significant.
  
  
  CONCLUSIONS
  The results of the present study suggest that subjects carrying at least one copy of the FcgammaRIIIb-NA2 allele might be associated with susceptibility to AgP. However, the clinical implications of the FcgammaRIIIb allelic polymorphism should be determined by further studies.
authors.affiliation: Department of Dentistry, Division of Periodontics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Ho
authors.forename: Yi-Hsin
authors.initials: YH
authors.lastname: Yang
authors.forename: Kun-Yen
authors.initials: KY
authors.lastname: Ho
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Wu
authors.forename: Chi-Cheng
authors.initials: CC
authors.lastname: Tsai
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000235:genetics* / Q000276:immunology; D000704:Analysis of Variance; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000235:genetics* / Q000276:immunology; D005260:Female; D058851:GPI-Linked Proteins / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D010512:Periodontal Index; D020641:Polymorphism, Single Nucleotide; D017452:Receptors, IgG / Q000235:genetics*; D012016:Reference Values; D013624:Taiwan
chemical_list: C428200:FCGR3B protein, human; D058851:GPI-Linked Proteins; D017452:Receptors, IgG