title: Effect of hydroxylpropyl-beta-cyclodextrin on Solubility of Carvedilol.
abstract: The present study was undertaken to examine the effect of pH and concentration of hydroxypropyl-beta-cyclodextrin on the solubility of carvedilol as it shows pH-dependent solubility. The equilibrium solubility of carvedilol in a series of solutions of varying pH (from 1.2 to 11) was determined and compared with the equilibrium solubility of carvedilol in the presence of 20% hydroxypropyl-beta-cyclodextrin at same pH values. It was observed that solubility of protonated form is more than neutral molecule. Hydroxypropyl-beta-cyclodextrin resulted in increased solubility at all the pH. But inclusion in the cavity of hydroxypropyl-beta-cyclodextrin might depend upon charge state of the molecule. So it can be concluded that solubility of carvedilol, can be increased either by the addition of hydroxypropyl-beta-cyclodextrin or by adding pH lowering agents. But both these methods if are to be used together, pH should be selected carefully.
authors.affiliation: H. R. Patel Women's Collage of Pharmacy, Karwand Naka (Shirpur)- 425 405, India.
authors.forename: B D
authors.initials: BD
authors.lastname: Shewale
authors.forename: N P
authors.initials: NP
authors.lastname: Sapkal
authors.forename: N A
authors.initials: NA
authors.lastname: Raut
authors.forename: N J
authors.initials: NJ
authors.lastname: Gaikwad
authors.forename: R A
authors.initials: RA
authors.lastname: Fursule