title: [A case of postoperative multiple liver metastases of pancreatic cancer successfully treated by combination chemotherapy with weekly high-dose 5-FU hepatic arterial infusion plus systemic infusion of gemcitabine].
abstract: We report a case of a 65-year-old man with postoperative multiple liver metastases of pancreatic cancer successfully treated with weekly high-dose 5-FU hepatic arterial infusion chemotherapy plus systemic infusion of gemcitabine. The patient was admitted because of suffering from epigastralgia and jaundice. He underwent pancreaticoduodenectomy for pancreatic head cancer and received postoperative adjuvant chemotherapy of gemcitabine. Abdominal CT after 6 months showed multiple liver metastases. Then we started a systemic gemcitabine (1,000 mg/body) infusion and weekly high- dose 5-FU (1,500 mg/body) hepatic arterial infusion chemotherapy. After 26 times of treatment, CT indicated that the tumors completely disappeared. He survived for 34 months after surgery. It has been suggested that this combined chemotherapy might be an effective treatment to control liver metastases of pancreatic cancer.
authors.affiliation: Department of Surgery, Nara Medical University.
authors.forename: Jin
authors.initials: J
authors.lastname: Doh
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sho
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Yamada
authors.forename: Takeo
authors.initials: T
authors.lastname: Nomi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Akahori
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yamato
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Nishiofuku
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Tamamoto
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kichikawa
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Nakajima
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000601:surgery; D016577:Pancreaticoduodenectomy; D011184:Postoperative Period; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D005472:Fluorouracil; D000093542:Gemcitabine