title: Severity of bronchopulmonary dysplasia and increased risk of feeding desaturation and growth delay in very low birth weight preterm infants.
abstract: Oral feeding has been reported to compromise breathing among preterm infants with bronchopulmonary dysplasia (BPD) during hospitalization or shortly after discharge. However, limited information was available concerning whether preterm infants with BPD remain vulnerable to feeding and growth insufficiency after a longer term of follow-up. The purpose of this study was therefore to examine the effect of severity of BPD on pulse oxygen saturation (SpO(2)) during feeding and growth in very low birth weight (VLBW) preterm infants during infancy. Seventy-two preterm infants with VLBW and 15 term infants were prospectively examined their growth and SpO(2) during feeding at 2, 4, and 6 months of corrected age. The severity of BPD was graded in VLBW infants according to the American National Institutes of Health consensus definition. In comparison to VLBW infants with mild BPD and term infants, VLBW infants with severe BPD showed significantly lower mean levels of SpO(2) during feeding at 2-6 months corrected age (P < 0.05). Those with severe BPD further exhibited higher rates of growth delay (weight < 10th percentile) throughout the study period. Among VLBW infants, severe BPD had an adverse relation with subsequent weight measures after adjustment for medical and demographic confounding variables (beta = -904 g, P = 0.03). The consensus BPD definition is useful to identify those preterm infants who are at greater risk of feeding desaturation and growth delay during infancy and close monitoring of SpO(2) during feeding should be advised.
authors.affiliation: School and Graduate Institute of Physical Therapy, National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Wang
authors.forename: Hong-Ji
authors.initials: HJ
authors.lastname: Luo
authors.forename: Wu-Shiun
authors.initials: WS
authors.lastname: Hsieh
authors.forename: Chyong-Hsin
authors.initials: CH
authors.lastname: Hsu
authors.forename: Hui-Chin
authors.initials: HC
authors.lastname: Hsu
authors.forename: Pei-Shan
authors.initials: PS
authors.lastname: Chen
authors.forename: Nan-Chang
authors.initials: NC
authors.lastname: Chiu
authors.forename: Wang-Tso
authors.initials: WT
authors.lastname: Lee
authors.forename: Suh-Fang
authors.initials: SF
authors.lastname: Jeng
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology*; D002657:Child Development; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007228:Infant Nutrition Disorders / Q000453:epidemiology*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D019102:Infant, Very Low Birth Weight / Q000254:growth & development*; D008137:Longitudinal Studies; D008297:Male; D010100:Oxygen / Q000097:blood; D012306:Risk
chemical_list: D010100:Oxygen