title: Synthesis and antimicrobial activity of some pyridinium salts.
abstract: Some substituted benzylidenehydrazinylpyridinium derivatives bearing benzyl, ethylphenyl and propylphenyl groups on the pyridinium nitrogen were synthesized and screened for possible antibacterial and antifungal activities against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans using the microdilution method. Antimicrobial test results indicated that compounds containing a 3-phenylpropyl chain displayed the highest antimicrobial activity against Staphylococcus aureus and the compound 3d was the most active in the series against all tested bacteria and fungi strains.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, 35100, Bornova, Izmir, Turkey. vildan.alptuzun@ege.edu.tr
authors.forename: Vildan
authors.initials: V
authors.lastname: Alptüzün
authors.forename: Sülünay
authors.initials: S
authors.lastname: Parlar
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Taşli
authors.forename: Ercin
authors.initials: E
authors.lastname: Erciyas
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D012492:Salts; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011726:Pyridinium Compounds; D012492:Salts