Nanosized self-emulsifying lipid vesicles of diacylglycerol-PEG lipid conjugates: biophysical characterization and inclusion of lipophilic dietary supplements.
Hydrated diacylglycerol-PEG lipid conjugates, glyceryl dioleate-PEG12 (GDO-PEG12) and glyceryl dipalmitate-PEG23 (GDP-PEG23), spontaneously form uni- or oligolamellar liposomes in their liquid crystalline phase, in distinct difference from the PEGylated phospholipids which form micelles. GDP-PEG23 exhibits peculiar hysteretic phase behavior and can arrange into a long-living hexagonal phase at ambient and physiological temperatures. Liposomes of GDO-PEG12 and its mixture with soy lecithin exchange lipids with the membranes much more actively than common lecithin liposomes; such an active lipid exchange might facilitate the discharging of the liposome cargo upon uptake and internalization, and can thus be important in drug delivery applications. Diacylglycerol-PEG lipid liposome formulations can encapsulate up to 20-30wt.% lipophilic dietary supplements such as fish oil, coenzyme Q10, and vitamins D and E. The encapsulation is feasible by way of dry mixing, avoiding the use of organic solvent.
Koynova
Rumiana
R
Ohio State University College of Pharmacy, 517 Parks Hall, 500 W 12th Ave, Columbus, OH 43210, USA. rkoynova@gmail.com
Tihova
Mariana
M
D055592:Biophysical Phenomena / Q000187:drug effects; D002725:Chloroform; D019587:Dietary Supplements; D004075:Diglycerides / Q000737:chemistry*; D004655:Emulsions; D005395:Fish Oils / Q000494:pharmacology; D054709:Lecithins / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry* / Q000648:ultrastructure; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D008567:Membranes, Artificial; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D044367:Phase Transition / Q000187:drug effects; D011092:Polyethylene Glycols / Q000737:chemistry*; D053838:Scattering, Small Angle; D012996:Solutions; D013696:Temperature; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000494:pharmacology; D014807:Vitamin D / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology; D014961:X-Ray Diffraction
D004075:Diglycerides; D004655:Emulsions; D005395:Fish Oils; D054709:Lecithins; D008081:Liposomes; D008567:Membranes, Artificial; D012996:Solutions; D014451:Ubiquinone; D014807:Vitamin D; D014810:Vitamin E; D011092:Polyethylene Glycols; D002725:Chloroform; C024989:coenzyme Q10