title: [Microcalorimetric investigation of two cephalosporins on colon bacteria activity].
abstract: The effects of cephradinum and ceftazidime on the metabolism of Escherichia coli (E. coli) DH5alpha was determined by microcalorimetry. The microbial activity was recorded as power-time curves through an ampoule method with a TAM Air Isothermal Microcalorimeter at 37 degrees C. The parameters such as the growth rate constant (k), inhibitory ratio (I), the maximum power output (Pm) and the time (tm) corresponding to the maximum power output were calculated. The results show that the ceftazidime has a better inhibitory effect on E. coli DH5alpha than cephradinum.
authors.affiliation: College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Xu
authors.forename: Cheng-Gong
authors.initials: CG
authors.lastname: Song
authors.forename: Rui-Hua
authors.initials: RH
authors.lastname: Wu
authors.forename: Li-Ni
authors.initials: LN
authors.lastname: Yang
authors.forename: Li-Xian
authors.initials: LX
authors.lastname: Sun
authors.forename: Zong-Bao
authors.initials: ZB
authors.lastname: Zhao
authors.forename: Zhi-Heng
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Cao
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002151:Calorimetry / Q000379:methods*; D002442:Ceftazidime / Q000008:administration & dosage / Q000494:pharmacology*; D002515:Cephradine / Q000008:administration & dosage / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D002442:Ceftazidime; D002515:Cephradine