title: Effect of endemic fluorosis on hematological parameters.
abstract: Although so many studies exist on effect of fluoride on hematological parameters in experimental animals, a few studies have been conducted to investigate the effects of chronic fluorosis on hematological parameters in humans' subjects with endemic fluorosis. So we aimed to determine the hematological parameters in patients with endemic fluorosis. The study group consisted of 60 patients with endemic fluorosis (27 females, 33 males, and mean age 33.4 ± 9.6 years). An age-, gender-, and body mass index-matched control group was composed of 34 healthy volunteers (11 females, 23 males with a mean age 32.6 ± 5.6 years). Urine fluoride levels of fluorosis patients were significantly higher than control subjects as expected (0.42 ± 0.09 vs 1.92 ± 0.14 mg/l, respectively; P < 0.001). There were no statistically significant differences between the fluorosis group and control group with respect to hematological parameters (complete blood count and ferritin). We concluded that chronic fluorosis has no effect on hematological parameters in patients with endemic fluorosis.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Suleyman Demirel University, Cunur, 32200 Isparta, Turkey.
authors.forename: Ismail Hakki
authors.initials: IH
authors.lastname: Ersoy
authors.forename: E Guçhan
authors.initials: EG
authors.lastname: Alanoglu
authors.forename: Banu Kale
authors.initials: BK
authors.lastname: Koroglu
authors.forename: Simge
authors.initials: S
authors.lastname: Varol
authors.forename: Selahaddin
authors.initials: S
authors.lastname: Akcay
authors.forename: Yunus
authors.initials: Y
authors.lastname: Ugan
authors.forename: Sıddıka
authors.initials: S
authors.lastname: Ersoy
authors.forename: Mehmet Numan
authors.initials: MN
authors.lastname: Tamer
mesh_terms: D000328:Adult; D019353:Endemic Diseases; D005260:Female; D005459:Fluorides / Q000097:blood* / Q000652:urine*; D009050:Fluorosis, Dental / Q000097:blood* / Q000652:urine; D006801:Humans; D008297:Male
chemical_list: D005459:Fluorides