Subchondral bone in osteoarthritis physiopathology: state-of-the art and perspectives.
Osteoarthritis (OA) is the most common form of arthritic disease, and it is a major cause of disability and impaired quality of life in the elderly. A hallmark of the disease is progressive degeneration of articular cartilage and subsequent joint space narrowing. However, OA is a complex disease not limited to cartilage degeneration, but involving also synovial membrane and subchondral bone, thereby presenting alternatives approaches for treatment. In this paper, we propose a short review of the recent advances in the understanding of the role played by subchondral bone in OA.
Henrotin
Y
Y
Bone and Cartilage Research Unit, Institute of Pathology, CHU Sart-Tilman, University of Liège, Liège, Belgium. yhenrotin@ulg.ac.be
Pesesse
L
L
Sanchez
C
C
D001842:Bone and Bones / Q000473:pathology* / Q000503:physiopathology*; D002358:Cartilage, Articular / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D010003:Osteoarthritis / Q000473:pathology* / Q000503:physiopathology*