Antipsychotic prescribing trends: a review of pharmaco-epidemiological studies.
OBJECTIVE
To review findings from pharmaco-epidemiological studies exploring antipsychotic (AP) drugs prescribing trends.


METHODS
We retrieved original studies that explored AP prescribing trends in general population samples since 2000. For each study, we extracted information on sampling method, period, assessment of AP use and corresponding estimates (incidence rates, prevalence rates, pharmacy sales, prescription data) and diagnostic assessment.


RESULTS
Nearly all studies meeting the inclusion criteria (n = 17) showed an increase in AP prescriptions, mainly because of a dramatic rise in second-generation antipsychotics (SGAP) prescriptions. APs are often prescribed for non-psychotic disorders in adults as well as in children and adolescents.


CONCLUSIONS
Considering the growing number of persons from the general population exposed to APs, population studies assessing the risk/benefit ratio of SGAP use in disorders other than psychosis are necessary, particularly in children and adolescents.
Verdoux
H
H
INSERM U657, Université Victor Segalen Bordeaux2, Bordeaux Cedex, France.
Tournier
M
M
Bégaud
B
B
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002648:Child; D055808:Drug Discovery / Q000639:trends; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D004363:Drug Utilization / Q000639:trends; D006801:Humans; D016239:MEDLINE / Q000706:statistics & numerical data; D001523:Mental Disorders / Q000188:drug therapy; D056687:Off-Label Use / Q000706:statistics & numerical data; D017891:Pharmacoepidemiology / Q000706:statistics & numerical data* / Q000639:trends; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data / Q000639:trends
D014150:Antipsychotic Agents