title: Vesical instillations of hyaluronic acid to reduce the acute vesical toxicity caused by high-dose brachytherapy do not affect the survival: a five-year follow-up study.
abstract: OBJECTIVE
  To determine whether the intravesical use of hyaluronic acid (HA) reduces acute and late vesical toxicity induced by radiotherapy.
  
  
  METHODS
  Single-centre retrospective study of patients diagnosed with cervical and endometrial cancer treated with brachytherapy (BT) with or without intravesical instillation of HA. Patients were assigned consecutively to the two treatment groups. Forty milligrams of HA was instilled intravesically for approximately 30 min prior to each BT session. Rates of acute and late vesical toxicity were recorded using the RTOG criteria.
  
  
  RESULTS
  Ninety-five clinical histories were reviewed (48 with HA instillation and 47 without). Surgery had been performed in 85.3% of cases, external radiotherapy in 76.8% and chemotherapy in 25.3%. There were no significant differences between groups with regard to the total number of BT sessions, dose per session, total dose or biological equivalent dose. In all the sessions the percentage of patients presenting acute vesical toxicity was lower in the HA group, the differences being statistically significant (p<0.05) after the 2nd (20.8% vs. 40.4%) and 4th sessions (10.9% vs. 31.9%). No patients in the HA group presented vesical toxicity after six months of follow-up. Over the whole study period, the percentage of patients presenting vesical toxicity of degree 2 or more was significantly lower in the HA group (2.08% vs. 12.8%; p<0.05).
  
  
  CONCLUSIONS
  Vesical instillations of HA decrease the incidence and the degree of acute vesical toxicity induced by high-dose BT, and reduce the percentage of patients that develop toxicity of degree 2 or more.
authors.affiliation: Servicio de Oncología Radioterápica, Hospital Central de la Defensa Gómez Ulla, Madrid, Spain. psamots@oc.mde.es
authors.forename: Pilar Ma
authors.initials: PM
authors.lastname: Samper Ots
authors.forename: Concha
authors.initials: C
authors.lastname: López Carrizosa
authors.forename: Aurora
authors.initials: A
authors.lastname: Rodríguez
authors.forename: Juan
authors.initials: J
authors.lastname: de Dios Sáez
authors.forename: José María
authors.initials: JM
authors.lastname: Delgado
authors.forename: Manuel
authors.initials: M
authors.lastname: Martín de Miguel
authors.forename: Montserrat
authors.initials: M
authors.lastname: Vidal
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D000283:Administration, Intravesical; D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods; D019610:Cytoprotection / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D005833:Genital Neoplasms, Female / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D011832:Radiation Injuries / Q000401:mortality / Q000517:prevention & control*; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000187:drug effects / Q000528:radiation effects
chemical_list: D006820:Hyaluronic Acid