A fast ruthenium polypyridine cage complex photoreleases glutamate with visible or IR light in one and two photon regimes.
We introduce a new caged glutamate, based in a ruthenium bipyridyl core, that undergoes heterolytic cleavage after irradiation with visible light with wavelengths up to 532nm, yielding free glutamate in less than 50ns. Glutamate photorelease occurs also efficiently following two-photon (2P) excitation at 800nm, and has a functional cross section of 0.14GM.
Salierno
Marcelo
M
Departamento de Química Inorgánica, Analítica y Química Física, INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina.
Marceca
Ernesto
E
Peterka
Darcy S
DS
Yuste
Rafael
R
Etchenique
Roberto
R
D000818:Animals; D018698:Glutamic Acid / Q000737:chemistry*; D007259:Infrared Rays; D008027:Light; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D010775:Photic Stimulation / Q000379:methods*; D017785:Photons; D012428:Ruthenium / Q000737:chemistry*
D018698:Glutamic Acid; D012428:Ruthenium