[The immunomodulatory effects of sijunzi decoction and its disassembled prescription on D-galactose-induced aging mice].
OBJECTIVE
To observe the immunomodulatory effects of codonopsis, atractylodes macrocephala, tuceahoe, broiled licorice and sijunzi decoction on D-galactose-induced aging mice.


METHODS
The models of aging mice were induced by D-galactose, the garlands and splenic lymphocyte transformation test (MTT) were used to determine the ability of erythrocytes immune and lymphocytes conversion; The content of maleic dialdehyde (MDA), activity of superoxide dismutase (SOD) and glutathione pemfidase (GSH-Px) in serum were detected.


RESULTS
Sijunzi decoction and its disassembled prescription codonopsis could significantly increase the ability of T lymphocyte transformation (P<0.05); Atractylodes macrocephala and sijunzi decoction could significantly enhance C(3b) garlands ratio (P<0.05) and decrease IC garlands ratio (P<0.05) on D-galactose-induced aging mice. Sijunzi decoction significantly increased the activity of SOD and GSH-Px (P<0.01), and decreased the content of MDA in serum (P<0.05).


CONCLUSIONS
Sijunzi decoction and its disassembled prescription codonopsis, atractylodes macrocephala can improve the immunomodulatory effects on D-galactose-induced aging mice; but tuceahoe and broiled licorice have no obvious effects.
Cheng
Wen-li
WL
The Sixth Affiliated Hospital of Sun Yat-sen University of Guangzhou, Guangzhou 510655, China.
Wang
Xiu-yin
XY
Jiang
Zhen-you
ZY
Pan
Jing-qiang
JQ
Dong
Jun
J
Kuang
Shao-song
SS
Rao
Zi-liang
ZL
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000375:Aging / Q000187:drug effects* / Q000276:immunology; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology*; D005260:Female; D005690:Galactose / Q000008:administration & dosage; D008213:Lymphocyte Activation / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D008815:Mice, Inbred Strains; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D013154:Spleen / Q000166:cytology; D013482:Superoxide Dismutase / Q000097:blood
D000276:Adjuvants, Immunologic; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005690:Galactose