title: Effect of refrigeration of the antiemetic Cerenia (maropitant) on pain on injection.
abstract: Injection pain has been associated with veterinary use of the antiemetic maropitant (Cerenia, Pfizer Animal Health). Cerenia is formulated using sulphobutylether-beta-cyclodextrin to bind maropitant and mitigate injection pain. The objective of this study was to determine whether the temperature of Cerenia alters binding between maropitant and sulphobutylether-beta-cyclodextrin and affects injection pain. Binding decreased as temperature increased, and Cerenia-elicited injection pain increased at warmer drug temperatures. These data suggest that the amount of free unbound maropitant increases with temperature and that injection pain increases with temperature in a similar fashion. Clinically, these studies suggest that injection of refrigerated Cerenia may significantly reduce or eliminate pain associated with SC injection of Cerenia.
authors.affiliation: Pfizer Animal Health, Discovery Research, 7000 Portage Road, Kalamazoo, MI 49001, USA.
authors.forename: Sunil Thomas
authors.initials: ST
authors.lastname: Narishetty
authors.forename: Betsy
authors.initials: B
authors.lastname: Galvan
authors.forename: Eileen
authors.initials: E
authors.lastname: Coscarelli
authors.forename: Michelle
authors.initials: M
authors.lastname: Aleo
authors.forename: Tim
authors.initials: T
authors.lastname: Fleck
authors.forename: William
authors.initials: W
authors.lastname: Humphrey
authors.forename: Robert B
authors.initials: RB
authors.lastname: McCall
mesh_terms: D000818:Animals; D000932:Antiemetics / Q000008:administration & dosage* / Q000009:adverse effects*; D004283:Dog Diseases / Q000139:chemically induced; D004285:Dogs; D005079:Excipients; D010146:Pain / Q000139:chemically induced*; D011812:Quinuclidines / Q000008:administration & dosage* / Q000009:adverse effects* / Q000737:chemistry; D012034:Refrigeration; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D000932:Antiemetics; D005079:Excipients; D011812:Quinuclidines; D047392:beta-Cyclodextrins; C093196:SBE4-beta-cyclodextrin; C518176:maropitant