title: [Successful chemoradiation therapy for local control of rectal cancer with multiple bone metastases--a case report].
abstract: A 78-year-old man was admitted to our institute with the symptom of melena. The patient was diagnosed as having advanced rectal cancer (T4N2M1) with multiple bone metastases. Chemoradiation therapy was chosen for the local control because our proposal of colostomy was rejected. Concurrent chemoradiation therapy [46 Gy/23 Fr+tegafur/uraci (l UFT 400 mg/m2)/calcium folinate (Leucovorin: LV 75 mg/body)] resulted in a good partial response and the patient became asymptomatic. UFT/LV were administrated and most of the bone metastases were diminished. After 3 years of disease remission with good quality of life, local tumor recurred with the symptoms of melena and bowel obstruction. Colostomy and additional radiotherapy were performed for the palliation. He died after 4 years from the initial treatment. In advanced rectal cancer with distant metastases, chemoradiation therapy for local control plus systemic chemotherapy could be an alternative to improve quality of life.
authors.affiliation: Division of Gastroenterological Surgery, Department of Surgery, Graduate School of Medicine, Kobe University.
authors.forename: Tetsu
authors.initials: T
authors.lastname: Nakamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Kamigaki
authors.forename: Shiro
authors.initials: S
authors.lastname: Takase
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Sakai
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Yamashita
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sumi
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Matsuda
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Imanishi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Iwatani
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kuroda
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kuroda
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary*; D003131:Combined Modality Therapy; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D012004:Rectal Neoplasms / Q000473:pathology* / Q000628:therapy*
chemical_list: D002955:Leucovorin