Pathology in children of HIV women.
OBJECTIVE
To assess the frequency of perinatal pathology in children exposed to antiretrovirals in perinatal period.


METHODS
Retrospective observational cohort study.


METHODS
Retrospective observational cohort study. Data collected among uninfected children born to HIV-infected women followed up from 1994 to 2006 in a tertiary Hospital. 220 uninfected children were studied. Factors studied included maternal, obstetrical and pediatric variables.


RESULTS
The most common disorder found among children exposed to antiretroviral drugs was anemia (84%); 6,4% of children had neutropenia and more than 24% had thrombocytosis, a finding never described before. Prematurity (24%) and low birth weight (23.6%) rates were high. Several congenital malformations were found: Poland syndrome, angiomas, hypospadias, Pierre-Robin sequence, trisomy 8, craniostosis and others. Long-term follow-up revealed neurological, cardiological and ophthalmological pathologies.


CONCLUSIONS
Some pathologies are frequent among children exposed to antiretroviral agents during perinatal life. It is crucial to carry out long-term studies to assess the safety of this therapy.
Nso Roca
Ana Pilar
AP
Servicio Inmuno-Pediatría, Hospital Universitario La Paz, Madrid, Spain. ananso@yahoo.es
García-Bermejo
C García-Bermejo
CG
Larru
B
B
R
Madero
M
Muñoz Fernández
M A
MA
de José
M I
MI
D000015:Abnormalities, Multiple / Q000453:epidemiology; D000328:Adult; D000740:Anemia / Q000139:chemically induced* / Q000453:epidemiology*; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D009503:Neutropenia / Q000139:chemically induced* / Q000453:epidemiology*; D010500:Perinatology; D015995:Prevalence; D011644:Puerperal Disorders / Q000453:epidemiology* / Q000209:etiology*; D012189:Retrospective Studies; D013922:Thrombocytosis / Q000139:chemically induced* / Q000453:epidemiology*
D044966:Anti-Retroviral Agents