Cytotoxic neoclerodane diterpenoids from Scutellaria barbata.
Seven new neoclerodane diterpenoids, scutebatas A-G (1-7), have been isolated from Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their structures were elucidated by spectroscopic analysis, and the relative configuration of scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1. Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC(50) value of 15.2 muM.
Zhu
Feng
F
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
Di
Ying-Tong
YT
Liu
Ling-Li
LL
Zhang
Qiang
Q
Fang
Xin
X
Yang
Ting-Quan
TQ
Hao
Xiao-Jiang
XJ
He
Hong-Ping
HP
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045785:Diterpenes, Clerodane; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D031363:Scutellaria / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045785:Diterpenes, Clerodane; D004365:Drugs, Chinese Herbal; C468586:neoclerodane