Gd-functionalised Au nanoparticles as targeted contrast agents in MRI: relaxivity enhancement by polyelectrolyte coating.
Monolayer-protected, Gd(3+)-functionalised gold nanoparticles with enhanced spin-lattice relaxivity (r(1)) were prepared; adsorption of polyelectrolytes on these materials further increased r(1) and ligand exchange with a biotin-derivatised disulfide led to a prototype avidin-targeted contrast agent.
Warsi
Muhammad Farooq
MF
Department of Chemistry, University of York, Heslington, York, UK YO10 5DD.
Adams
Ralph W
RW
Duckett
Simon B
SB
Chechik
Victor
V
D001710:Biotin / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*
D003287:Contrast Media; D001710:Biotin; D006046:Gold; D005682:Gadolinium