Sibutramine selective electrodes for batch and flow injection determinations in pharmaceutical preparations.
The construction and electrochemical response characteristics of two new polyvinyl chloride (PVC) membrane sensors for the determination of sibutramine hydrochloride were described. The sensors are based on the ion association complexes of sibutramine with sodium tetraphenylborate (NaTPB) or phosphotungstic acid (PTA) using dibutyl phthalate as plasticizing solvent. The sensors display a fast, stable response over the concentration range 3.84 x 10(-5)-1.00 x 10(-2) M sibutramine hydrochloride monohydrate (SibuCl), with cationic slopes of 57.7 +/- 0.57 and 59.7 +/- 1.79 mV concentration decade(-1) and detection limits of 8.91 x 10(-6) and 1.47 x 10(-5) M in case of sibutramine-tetraphenylborate (Sibu-TPB) and sibutramine-phosphotungstate ((Sibu)(3)-PT), respectively. The proposed sensors have been successfully applied for the determination of sibutramine hydrochloride in Regitrim capsules in batch and flow injection (FI) conditions.
Zayed
S I M
SI
Faculty of Industrial Education, Beni Suef University, Beni Suef, Egypt. simam90@hotmail.com
Issa
Y M
YM
D001067:Appetite Depressants / Q000032:analysis*; D002138:Calibration; D002214:Capsules / Q000032:analysis; D003503:Cyclobutanes / Q000032:analysis*; D003993:Dibutyl Phthalate / Q000737:chemistry; D004566:Electrodes; D004573:Electrolytes / Q000737:chemistry; D017022:Flow Injection Analysis; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations / Q000032:analysis*; D010772:Phosphotungstic Acid / Q000737:chemistry; D011143:Polyvinyl Chloride / Q000737:chemistry; D011199:Potentiometry; D013696:Temperature; D013775:Tetraphenylborate / Q000737:chemistry
D001067:Appetite Depressants; D002214:Capsules; D003503:Cyclobutanes; D004573:Electrolytes; D007202:Indicators and Reagents; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations; D010772:Phosphotungstic Acid; D003993:Dibutyl Phthalate; D013775:Tetraphenylborate; D011143:Polyvinyl Chloride; C058254:sibutramine