title: Role of color Doppler indices in predicting disease-free survival of breast cancer patients during neoadjuvant chemotherapy.
abstract: The aim of our study was to evaluate whether blood flow in locally advanced and inflammatory breast cancer before and after neoadjuvant chemotherapy using color Doppler ultrasonography can be used to monitor the response to therapy and identify possible correlations between survival and various Doppler indices. Fifty patients with breast cancer underwent Doppler evaluation of the tumor with determination of Doppler indices such as pulsatility index (PI), resistive index (RI), and peak systolic velocity (PSV). RI and PI decreased in 27 (54%) and 20 (40%) patients, respectively, and increased in 23 (46%) and 30 (60%) patients, respectively. Thirty (60%) patients showed a decrease in PSV and 20 (40%) patients an increase. Patients with an intratumoral blood flow velocity increase after chemotherapy had a greater likelihood of local recurrence and metastasis compared with patients in whom flow velocity decreased after chemotherapy. The study also confirmed a greater correlation between Doppler PSV and clinical assessment. Tumor flow velocity measured by Doppler ultrasound can be used as an independent marker of disease-free survival in patients with breast cancer.
authors.affiliation: Medical Physics Unit, IRCH, AIIMS, New Delhi 110029, India. guraiims@gmail.com
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Singh
authors.forename: Pratik
authors.initials: P
authors.lastname: Kumar
authors.forename: Rajinder
authors.initials: R
authors.lastname: Parshad
authors.forename: Ashu
authors.initials: A
authors.lastname: Seith
authors.forename: Sanjay
authors.initials: S
authors.lastname: Thulkar
authors.forename: Norbert
authors.initials: N
authors.lastname: Hosten
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000188:drug therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011673:Pulsatile Flow; D018615:Ultrasonography, Doppler, Color; D014655:Vascular Resistance
chemical_list: D000970:Antineoplastic Agents