title: MMP9 but Not EGFR, MET, ERCC1, P16, and P-53 Is Associated with Response to Concomitant Radiotherapy, Cetuximab, and Weekly Cisplatin in Patients with Locally Advanced Head and Neck Cancer.
abstract: Concomitant administration of radiotherapy with cisplatin or radiotherapy with cetuximab appear to be the treatment of choice for patients with locally advanced head and neck cancer. In the present retrospective analysis, we investigated the predictive role of several biomarkers in an unselected cohort of patients treated with concomitant radiotherapy, weekly cisplatin, and cetuximab (CCRT). We identified 37 patients treated with this approach, of which 13 (35%) achieved a complete response and 10 (27%) achieved a partial response. Severe side effects were mainly leucopenia, dysphagia, rash, and anemia. Tumor EGFR, MET, ERCC1, and p-53 protein and/or gene expression were not associated with treatment response. In contrast, high MMP9 mRNA expression was found to be significantly associated with objective response. In conclusion, CCRT is feasible and active. MMP9 was the only biomarker tested that appears to be of predictive value in cetuximab treated patients. However, this is a hypothesis generating study and the results should not be viewed as definitive evidence until they are validated in a larger cohort.
authors.affiliation: Department of Medical Oncology, "Papageorgiou" Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Fountzilas
authors.forename: Anna
authors.initials: A
authors.lastname: Kalogera-Fountzila
authors.forename: Sophia
authors.initials: S
authors.lastname: Lambaki
authors.forename: Ralph M
authors.initials: RM
authors.lastname: Wirtz
authors.forename: Angelos
authors.initials: A
authors.lastname: Nikolaou
authors.forename: Georgia
authors.initials: G
authors.lastname: Karayannopoulou
authors.forename: Mattheos
authors.initials: M
authors.lastname: Bobos
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Kotoula
authors.forename: Samuel
authors.initials: S
authors.lastname: Murray
authors.forename: Alexandros
authors.initials: A
authors.lastname: Lambropoulos
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Aravantinos
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Markou
authors.forename: Eleni
authors.initials: E
authors.lastname: Athanassiou
authors.forename: Despina
authors.initials: D
authors.lastname: Misailidou
authors.forename: Konstantine T
authors.initials: KT
authors.lastname: Kalogeras
authors.forename: Demosthenis
authors.initials: D
authors.lastname: Skarlos