title: CTLA4 gene variations and haplotypes in patients with lung cancer.
abstract: The CTLA4 protein downmodulates and terminates immune responses by sending inhibitory signals to activated T cells. In this study, six main single-nucleotide polymorphisms of the CTLA4 gene were investigated in 127 lung cancer patients and 124 healthy control subjects: -1722T/C, -1661 A/G, -318 C/T, +49A/G, +1822 C/T, and +6230 A/G (CT60). Statistical analyses revealed no significant differences in the frequencies of genotypes, alleles, and haplotypes between patients and control subjects. We also could not find significant association between CTLA4 variants and any defined lung tumor type. These six single-nucleotide polymorphisms in CTLA4 were not associated with susceptibility to lung cancer in Iranian population.
authors.affiliation: Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Narges
authors.initials: N
authors.lastname: Khaghanzadeh
authors.forename: Nasrollah
authors.initials: N
authors.lastname: Erfani
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Ghayumi
authors.forename: Abbas
authors.initials: A
authors.lastname: Ghaderi
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000235:genetics*; D001483:Base Sequence; D060908:CTLA-4 Antigen; D017931:DNA Primers; D005260:Female; D006239:Haplotypes; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
chemical_list: D015703:Antigens, CD; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D017931:DNA Primers