title: Rhabdomyolysis associated with olanzapine treatment in a child with Autism.
abstract: Children with autism often display difficult behaviors including tantrums, extreme irritability, and physical aggression. There is emerging evidence that olanzapine is useful in decreasing these disruptive behaviors. The most common adverse effects are weight gain and short-term sedation. On the other hand, olanzapine rarely causes rhabdomyolysis. We report a case with rhabdomyolysis in an autistic child just after 2 doses of olanzapine treatment. Initial creatine kinase value was 30,690 IU/L (range, 5-130 U/L), and rhabdomyolysis resolved with hydration and alkalinization over 7 days. Monitoring serum creatine kinase levels may be useful in pediatric cases after initiation of olanzapine treatment.
authors.affiliation: Department of Pediatric, School of Medicine, Dokuz Eylül University, Izmir, Turkey. pakizekarakaya@gmail.com
authors.forename: Pakize
authors.initials: P
authors.lastname: Karakaya
authors.forename: Uluç
authors.initials: U
authors.lastname: Yiş
authors.forename: Semra Hz
authors.initials: SH
authors.lastname: Kurul
authors.forename: Mehmet Atilla
authors.initials: MA
authors.lastname: Türkmen
mesh_terms: D000293:Adolescent; D001321:Autistic Disorder / Q000188:drug therapy*; D001569:Benzodiazepines / Q000009:adverse effects* / Q000627:therapeutic use; D003402:Creatine Kinase / Q000097:blood; D005440:Fluid Therapy / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D000077152:Olanzapine; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000201:enzymology / Q000628:therapy; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D001569:Benzodiazepines; D003402:Creatine Kinase; D000077152:Olanzapine; D017367:Selective Serotonin Reuptake Inhibitors