[Chemotherapeutic wafers in treatment of malignant cerebral glioma. Assessment of a Cochrane review].
The present Cochrane review deals with implantation of chemotherapeutic wafers in the surgical cavity after resection of a malignant glioma. The authors found two controlled, randomised studies concerning this treatment modality after first-time surgical treatment and one study dealing with treatment of recurrent tumour. An effect was shown in the first with an increase in median survival of 2 months equivalent to the survival seen after standard (concomitant) treatment. No effect was shown in recurrent tumour.
Kosteljanetz
Michael
M
Neurokirurgisk Afdeling NK 2092, Rigshospitalet, DK-2100 København Ø, Denmark. michael.kosteljanetz@rh.regionh.dk
Poulsen
Hans Skovgaard
HS
D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D002330:Carmustine / Q000008:administration & dosage*; D004343:Drug Implants; D019317:Evidence-Based Medicine; D005910:Glioma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D011379:Prognosis; D015996:Survival Rate; D016896:Treatment Outcome
D018906:Antineoplastic Agents, Alkylating; D004343:Drug Implants; D002330:Carmustine