title: Decreased serum levels of adiponectin in subjects with autism.
abstract: The neurobiological basis for autism remains poorly understood. We hypothesized that adipokines, such as adiponectin, may play a role in the pathophysiology of autism. In this study, we examined whether serum levels of adiponectin are altered in subjects with autism. We measured serum levels of adiponectin in male subjects with autism (n=31) and age-matched healthy male subjects (n=31). The serum levels of adiponectin in the subjects with autism were significantly lower than that of normal control subjects. The serum adiponectin levels in the subjects with autism were negatively correlated with their domain A scores in the Autism Diagnostic Interview-Revised, which reflects their impairments in social interaction. This study suggests that decreased levels of serum adiponectin might be implicated in the pathophysiology of autism.
authors.affiliation: Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.
authors.forename: Azusa
authors.initials: A
authors.lastname: Fujita-Shimizu
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakamura
authors.forename: Taishi
authors.initials: T
authors.lastname: Miyachi
authors.forename: Hideo
authors.initials: H
authors.lastname: Matsuzaki
authors.forename: Masanobu
authors.initials: M
authors.lastname: Kajizuka
authors.forename: Chie
authors.initials: C
authors.lastname: Shinmura
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Iwata
authors.forename: Shiro
authors.initials: S
authors.lastname: Suda
authors.forename: Kenji J
authors.initials: KJ
authors.lastname: Tsuchiya
authors.forename: Kaori
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Genichi
authors.initials: G
authors.lastname: Sugihara
authors.forename: Keiko
authors.initials: K
authors.lastname: Iwata
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Tsujii
authors.forename: Toshiro
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Nori
authors.initials: N
authors.lastname: Takei
authors.forename: Norio
authors.initials: N
authors.lastname: Mori
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D001321:Autistic Disorder / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D052242:Adiponectin