Synthesis of beta-aminoketones and construction of highly substituted 4-piperidones by mannich reaction induced by persistent radical cation salts.
A Mannich reaction of imines and ketones induced by persistent radical cation salts was investigated, and a series of Mannich bases, beta-aminoketones, were synthesized. A novel cyclization to form the 4-piperidone skeleton was achieved in a tandem process. The reaction can be rationalized as a radical cation process supported by various evidence.
Jia
Xiao-Dong
XD
Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China. jiaxd1975@163.com
Wang
Xiao-E
XE
Yang
Cai-Xia
CX
Huo
Cong-De
CD
Wang
Wen-Juan
WJ
Ren
Yan
Y
Wang
Xi-Cun
XC