[Immune recovery following allogeneic hematopoietic cell transplantation].
Allogeneic hematopoietic stem cell transplantation (alloHCT) is frequently used as treatment for patients with hematological malignancies. Its efficacy depends in part on the destruction of recipient tumor cells by donor immune cells contained in the graft (graft-versus-tumor effects), underlying the interest of studying donor immune recovery after alloHCT. Further, donor immune cells play an important role in the prevention and treatment of infections after alloHCT, and are the cause of graft-versus-host disease (GVHD). This article reviews the mechanisms of immune recovery after allogeneic hematopoietic cell transplantation (alloHCT), as well as techniques currently used to monitor immune function following alloHCT.
Castermans
E
E
Service d'Hématologie, CHU de Liège, Liège, Belgique.
Hannon
M
M
Drion
P
P
Geenen
V
V
Beguin
Y
Y
Baron
F
F
D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007107:Immune System / Q000502:physiology; D012038:Regeneration; D013601:T-Lymphocytes / Q000502:physiology*; D014184:Transplantation, Homologous