title: [Contemporary opinions on pathogenesis, genetics and clinical picture of laterality disorders - left-right axis development defects].
abstract: Congenital malformations pose a great challenge to all medical specialities. Laterality defects belong to the group of congenital anomalies resulting from left-right axis development disturbances which arise at an early stage of embryogenesis. The authors discuss selected embryological, epidemiological, genetic and clinical aspects of left-right axis malformations. Furthermore recent knowledge concerning new genes involved in left-right asymmetry development is presented.
authors.affiliation: Katedra Genetyki AM we Wrocławiu.
authors.forename: Błazej
authors.initials: B
authors.lastname: Misiak
authors.forename: Robert
authors.initials: R
authors.lastname: Smigiel
mesh_terms: D001921:Brain / Q000002:abnormalities* / Q000196:embryology; D007839:Functional Laterality; D006801:Humans; D007231:Infant, Newborn; D012857:Situs Inversus / Q000175:diagnosis / Q000196:embryology / Q000235:genetics; D013577:Syndrome