Active search for chronic thromboembolic pulmonary hypertension does not appear indicated after acute pulmonary embolism.
BACKGROUND
Chronic thromboembolic pulmonary hypertension (CTEPH) is a life threatening but often, by pulmonary endarterectomy, curable disease. The incidence of CTEPH after an acute pulmonary embolism (PE) appears to be much higher than previously thought. Systematic follow-up of patients after PE might increase the number of diagnosed CTEPH patients.


OBJECTIVE
To study whether, compared to current clinical practice, a systematic search for CTEPH in patients after acute PE would increase the number of patients diagnosed with symptomatic, potentially treatable CTEPH.


METHODS
Consecutive patients with a prior diagnosis of acute PE were presented with a questionnaire, designed to establish the presence of either new or worsened dyspnea after the acute PE episode. If so, patients were evaluated for the presence of CTEPH.


RESULTS
PE patients (n=110; 56+/-18 years) were included after a median follow-up of three years. Overall mortality was 34% (37 patients); 1 patient had died due to CTEPH. In total 62 out of 69 questionnaires were returned; 23 patients reported new or worsened dyspnea related to the PE episode, and qualified for additional testing. In 2 patients, CTEPH was already diagnosed prior to this study. None of the remaining patients met the criteria for the diagnosis of CTEPH. The overall incidence of 2.7% (3/110; 95%CI 0.6-7.8%) is in agreement with earlier reported incidences.


CONCLUSIONS
Our findings do not point to a role for a systematic search and pro-active approach towards patients with a recent history of pulmonary embolism to increase the number of patients diagnosed with potentially treatable CTEPH.
Surie
Sulaiman
S
Department of Pulmonology, Academical Medical Center Amsterdam, the Netherlands. s.surie@amc.uva.nl
Gibson
Nadine S
NS
Gerdes
Victor E A
VE
Bouma
Berto J
BJ
van Eck-Smit
Berthe L F
BL
Buller
Harry R
HR
Bresser
Paul
P
D015984:Causality; D015897:Comorbidity; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000453:epidemiology*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors