title: Respiratory function and pulmonary lesions in pigs infected with porcine reproductive and respiratory syndrome virus.
abstract: Pulmonary dysfunction was evaluated in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV, isolate VR-2332) and compared to clinical and pathological findings. Infected pigs developed fever, reduced appetite, respiratory distress and dullness at 9 days post-inoculation (dpi). Non-invasive pulmonary function tests using impulse oscillometry and rebreathing of test gases (He, CO) revealed peripheral airway obstruction, reduced lung compliance and reduced lung CO-transfer factor. PRRSV-induced pulmonary dysfunction was most marked at 9-18 dpi and was accompanied by a significantly increased respiratory rate and decreased tidal volume. Expiration was affected more than inspiration. On histopathological examination, multifocal areas of interstitial pneumonia (more severe and extensive at 10 dpi than 21 dpi) were identified as a possible structural basis for reduced lung compliance and gas exchange disturbances.
authors.affiliation: Institute of Molecular Pathogenesis in the Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Naumburger Str 96a, 07743 Jena, Germany.
authors.forename: Judith
authors.initials: J
authors.lastname: Wagner
authors.forename: Annette
authors.initials: A
authors.lastname: Kneucker
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Liebler-Tenorio
authors.forename: Vicky
authors.initials: V
authors.lastname: Fachinger
authors.forename: Melanie
authors.initials: M
authors.lastname: Glaser
authors.forename: Stefan
authors.initials: S
authors.lastname: Pesch
authors.forename: Michael P
authors.initials: MP
authors.lastname: Murtaugh
authors.forename: Petra
authors.initials: P
authors.lastname: Reinhold
mesh_terms: D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D016133:Polymerase Chain Reaction / Q000662:veterinary; D019318:Porcine Reproductive and Respiratory Syndrome / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D019316:Porcine respiratory and reproductive syndrome virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D012129:Respiratory Function Tests / Q000662:veterinary; D013552:Swine