title: Phosphine-mediated stereoselective reductive cyclopropanation of alpha-substituted allenoates with aromatic aldehydes.
abstract: A novel phosphine-mediated reductive cyclopropanation between alpha-substituted allenoates 2 and aldehydes 1 is described. It represents a new member of the allene-based annulations, which provides facile and efficient access to highly functionalized cyclopropanes 3 from simple and readily available starting materials. It also unveils an unprecedented reactivity pattern of allenoates with aldehydes.
authors.affiliation: The State Key Laboratory of Elemento-Organic Chemistry and Department of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, P.R. China.
authors.forename: Silong
authors.initials: S
authors.lastname: Xu
authors.forename: Lili
authors.initials: L
authors.lastname: Zhou
authors.forename: Renqin
authors.initials: R
authors.lastname: Ma
authors.forename: Haibin
authors.initials: H
authors.lastname: Song
authors.forename: Zhengjie
authors.initials: Z
authors.lastname: He
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000466:Alkadienes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000466:Alkadienes; D003521:Cyclopropanes; D010720:Phosphines; C044646:phosphine