title: Human histologic evaluation of anorganic bovine bone mineral combined with recombinant human platelet-derived growth factor BB in maxillary sinus augmentation: case series study.
abstract: The objective of this proof-of-principle study was to examine the potential for improved bone regenerative outcomes in maxillary sinus augmentation procedures when recombinant human platelet-derived growth factor BB (0.3 mg/mL) is combined with particulate anorganic bovine bone mineral. The surgical outcomes in all treated sites were uneventful at 6 to 8 months, with sufficient regenerated bone present to allow successful placement of maxillary posterior implants. Large areas of dense, well-formed lamellar bone were seen throughout the intact core specimens in more than half of the grafted sites. Abundant numbers of osteoblasts were noted in concert with significant osteoid in all sites, indicating ongoing osteogenesis. A number of cores demonstrated efficient replacement of the normally slowly resorbing anorganic bovine bone mineral matrix particles with newly formed bone when the matrix was saturated with recombinant human platelet-derived growth factor BB.
authors.affiliation: Division of Periodontology, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts 02114, USA. nevinsperimp@aol.com
authors.forename: Myron
authors.initials: M
authors.lastname: Nevins
authors.forename: David
authors.initials: D
authors.lastname: Garber
authors.forename: James J
authors.initials: JJ
authors.lastname: Hanratty
authors.forename: Bradley S
authors.initials: BS
authors.lastname: McAllister
authors.forename: Marc L
authors.initials: ML
authors.lastname: Nevins
authors.forename: Maurice
authors.initials: M
authors.lastname: Salama
authors.forename: Peter
authors.initials: P
authors.lastname: Schupbach
authors.forename: Steven
authors.initials: S
authors.lastname: Wallace
authors.forename: Simon M
authors.initials: SM
authors.lastname: Bernstein
authors.forename: David M
authors.initials: DM
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000077214:Becaplermin; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes; D002417:Cattle; D003758:Dental Implantation, Endosseous; D005260:Female; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000601:surgery*; D008875:Middle Aged; D008903:Minerals; D013516:Oral Surgical Procedures, Preprosthetic; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D011446:Prospective Studies; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D055815:Young Adult
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008903:Minerals; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D000077214:Becaplermin