Iron metabolism markers and haptoglobin phenotypes in susceptibility to HSV-1 or/and HSV-2 lesion relapses.
Different haptoglobin (Hp) phenotypes play a role in several pathologic processes including infectious diseases. In order to evaluate the role of iron storage and metabolism in susceptibility to herpetic manifestations, we studied the frequency of the Hp phenotypes and iron metabolism in patients affected by H. Simplex virus 1 or 2 (HSV-1 or HSV-2), compared with controls. Hp phenotype and iron metabolism were determined in 100 patients with recurrent HSV-1 or HSV-2 manifestations during the relapses, and in 110 healthy subjects. The frequencies of the three Hp phenotypes in the patient group compared to the control group were 18% versus 14.5% p = NS for Hp 1.1, 25% versus 40% p = 0.03 for Hp 2.2 and 57% versus 45.5% p = NS for Hp 2.1. All iron metabolism parameters tested showed significant differences between patients and controls; haemoglobin (Hb), ferritin, and serum iron were lower, while transferrin was higher in the patients than in controls. Reductions in iron availability may be a risk factor for relapsing lesions of HSV-1 or HSV-2. Hp 2.2 phenotype may offer some protection against the recurrence of Herpes labialis or genitalis manifestations.
Gennero
Luisa
L
Department of Genetics, Biology and Biochemistry, CERMS, Centre for Experimental Research and Medical Studies, University of Turin, Italy. luisagennero@yahoo.com
Roos
Maria Augusta
MA
D'Amelio
Patrizia
P
Denysenko
Tetyana
T
Morra
Emanuella
E
Sperber
Kirk
K
Ceroni
Vincenzo
V
Panzone
Michele
M
Lesca
Franco
F
De Vivo
Enrico
E
Grimaldi
Anastasia
A
Gabetti
Maria Luisa
ML
Ponzetto
Antonio
A
Pescarmona
Gian Piero
GP
Pugliese
Agostino
A
D000328:Adult; D015415:Biomarkers / Q000097:blood; D004198:Disease Susceptibility; D005260:Female; D005293:Ferritins / Q000097:blood; D006242:Haptoglobins / Q000145:classification / Q000378:metabolism*; D006454:Hemoglobins / Q000032:analysis; D006558:Herpes Genitalis / Q000209:etiology*; D006560:Herpes Labialis / Q000209:etiology*; D018259:Herpesvirus 1, Human; D018258:Herpesvirus 2, Human; D006801:Humans; D007501:Iron / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012008:Recurrence; D012307:Risk Factors; D014168:Transferrin / Q000032:analysis
D015415:Biomarkers; D006242:Haptoglobins; D006454:Hemoglobins; D014168:Transferrin; D005293:Ferritins; D007501:Iron