title: Annual electrocardiograms consistent with silent progression of cardiac involvement in sporadic familial amyloid polyneuropathy: a case report.
abstract: Understanding the clinical characteristics of transthyretin familial amyloid polyneuropathy (TTR-FAP) is critical for early diagnosis and timely referral for liver transplantation. Here, we describe a 52-year-old man who had slight paresthesia for four years and whose final diagnosis of TTR-cardiac amyloidosis caused by sporadic FAP was delayed despite annual electrocardiography. Curative liver transplantation was postponed because of progressive cardiac involvement. This experience highlights the difficulties associated with diagnosing TTR-FAP, especially when it is sporadic, and underscores the importance of slight changes in ECG that could indicate FAP.
authors.affiliation: Cardiovascular Center, Department of Internal Medicine, Japanese Red Cross Society, Nagoya Daini Hospital, Nagoya. teru.takigawa@gmail.com
authors.forename: Masateru
authors.initials: M
authors.lastname: Takigawa
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Hashimura
authors.forename: Hatsue
authors.initials: H
authors.lastname: Ishibashi-Ueda
authors.forename: Naoaki
authors.initials: N
authors.lastname: Yamada
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kiso
authors.forename: Mamoru
authors.initials: M
authors.lastname: Nanasato
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Haruo
authors.initials: H
authors.lastname: Hirayama
mesh_terms: D028227:Amyloid Neuropathies, Familial / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D028226:Amyloidosis, Familial / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D018450:Disease Progression; D004562:Electrocardiography / Q000639:trends*; D006331:Heart Diseases / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged