Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis.
Antibiotic-induced bacteriolysis exacerbates inflammation and brain damage in bacterial meningitis. Here the quality and temporal kinetics of cerebrospinal fluid (CSF) inflammation were assessed in an infant rat pneumococcal meningitis model for the nonbacteriolytic antibiotic daptomycin versus ceftriaxone. Daptomycin led to lower CSF concentrations of interleukin 1beta (IL-1beta), IL-10, IL-18, monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1 alpha (MIP-1alpha) (P < 0.05). In experimental pneumococcal meningitis, daptomycin treatment resulted in more rapid bacterial killing, lower CSF inflammation, and less brain damage than ceftriaxone treatment.
Grandgirard
Denis
D
Laboratory for Experimental Neuroinfectiology, Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Oberson
Kevin
K
Bühlmann
Angela
A
Gäumann
Rahel
R
Leib
Stephen L
SL
D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002443:Ceftriaxone / Q000008:administration & dosage / Q000494:pharmacology*; D002555:Cerebrospinal Fluid / Q000187:drug effects / Q000276:immunology* / Q000382:microbiology; D017576:Daptomycin / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000382:microbiology; D008586:Meningitis, Pneumococcal / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D017576:Daptomycin