Shifting players and paradigms in cell-specific transcription.
Historically, developmental-stage- and tissue-specific patterns of gene expression were assumed to be determined primarily by DNA regulatory sequences and their associated activators, while the general transcription machinery including core promoter recognition complexes, coactivators, and chromatin modifiers was held to be invariant. New evidence suggests that significant changes in these general transcription factors including TFIID, BAF, and Mediator may facilitate global changes in cell-type-specific transcription.
D'Alessio
Joseph A
JA
Howard Hughes Medical Institute, University of California, Berkeley, 94720, USA.
Wright
Kevin J
KJ
Tjian
Robert
R
D000818:Animals; D018507:Gene Expression Regulation, Developmental; D056892:Mediator Complex / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D011401:Promoter Regions, Genetic; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D035182:TATA Box Binding Protein-Like Proteins / Q000235:genetics / Q000378:metabolism; D014018:Tissue Distribution; D035362:Transcription Factor TFIID / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D056892:Mediator Complex; D020033:Protein Isoforms; D035182:TATA Box Binding Protein-Like Proteins; D035362:Transcription Factor TFIID