title: Anthelmintic constituents of Clonostachys candelabrum.
abstract: Five diastereomeric polyketide glycosides, roselipins 3A-3E (1-5), have been isolated from the acetone extract of Clonostachys candelabrum on the basis of their positive anthelmintic activity. The structures of these compounds were elucidated by comparison of their NMR and MS data to those of previously reported roselipins and related structures, and were confirmed by 2D-NMR spectral analysis. Known compounds linoleic acid (6) and aurantiogliocladin (7) were also isolated as active anthelmintic components, although much less potent than the roselipins.
authors.affiliation: Natural Products Chemistry, Merck Research Laboratories, Rahway, NJ, USA.
authors.forename: Sloan
authors.initials: S
authors.lastname: Ayers
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Zink
authors.forename: Kenneth
authors.initials: K
authors.lastname: Mohn
authors.forename: Joanne S
authors.initials: JS
authors.lastname: Powell
authors.forename: Christine M
authors.initials: CM
authors.lastname: Brown
authors.forename: Gerald
authors.initials: G
authors.lastname: Bills
authors.forename: Alan
authors.initials: A
authors.lastname: Grund
authors.forename: Donald
authors.initials: D
authors.lastname: Thompson
authors.forename: Sheo B
authors.initials: SB
authors.lastname: Singh
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000737:chemistry* / Q000494:pharmacology*; D001681:Biological Assay; D002432:Cecum / Q000469:parasitology; D002851:Chromatography, High Pressure Liquid; D006999:Hypocreales / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D009349:Nematode Infections / Q000188:drug therapy / Q000469:parasitology; D009351:Nematospiroides dubius / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013270:Stomach / Q000469:parasitology; D013329:Structure-Activity Relationship
chemical_list: D000871:Anthelmintics; D007202:Indicators and Reagents