Magnetic resonance spectroscopic imaging (1H-MRSI) and dynamic contrast-enhanced magnetic resonance (DCE-MRI): pattern changes from inflammation to prostate cancer.
OBJECTIVE
To assess (1)H-magnetic resonance spectroscopic imaging ((1)H-MRSI) and dynamic contrast-enhanced magnetic resonance (DCE-MRI) features in histologically confirmed prostatic chronic inflammation, prostatic intraepithelial neoplasia (PIN), low grade prostate cancer (LGPCa), and high grade prostate cancer (HGPCa).


METHODS
Ninety-six men were selected, who showed at histology a diagnosis of chronic inflammation (Group B), high grade (HG) PIN (Group C), or prostate cancer (LGPCa = Group D and HGPCa = Group E).


RESULTS
ANOVA analysis shows that inflammation (Group B) displays no significantly (p >.05) different choline and citrate levels when compared to HGPIN and LGPCa.


CONCLUSIONS
our results suggest the potential for these MR imaging techniques in the description of inflammatory and proliferative lesions inside the prostate gland.
Sciarra
Alessandro
A
Department of Urology, Sapienza University, Viale Policlinico 155, Rome, Italy. sciarra.md@libero.it
Panebianco
Valeria
V
Ciccariello
Mauro
M
Salciccia
Stefano
S
Lisi
Danilo
D
Osimani
Marcello
M
Alfarone
Andrea
A
Gentilucci
Alessandro
A
Parente
Ulderico
U
Passariello
Roberto
R
Gentile
Vincenzo
V
D000368:Aged; D002908:Chronic Disease; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D011472:Prostatitis / Q000175:diagnosis* / Q000378:metabolism