title: Use of zoledronic acid in the treatment of Gorham's disease.
abstract: Gorham's disease (Gorham-Stout syndrome) is a rare condition of unknown etiology involving a localized endothelial proliferation of lymph vessels resulting in destruction with bone resorption. The syndrome is rarely seen in the facial skeleton and has a large variety of prognoses and treatments. A case of this syndrome in a 9-year-old boy is presented. The clinical aspects are described, together with the treatment involving zoledronic acid. Other treatments described in the literature are reviewed. The authors believe that this report is one of the first cases in which a child afflicted in the first decade of life survives.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Universidade de Pernambuco, Recife, Brazil. rafael.ctbmf@yahoo.com.br
authors.forename: Rafael Linard
authors.initials: RL
authors.lastname: Avelar
authors.forename: Valber Barbosa
authors.initials: VB
authors.lastname: Martins
authors.forename: Antonio Azoubel
authors.initials: AA
authors.lastname: Antunes
authors.forename: Patricio José
authors.initials: PJ
authors.lastname: de Oliveira Neto
authors.forename: Emanuel Sávio de Souza
authors.initials: ES
authors.lastname: Andrade
mesh_terms: D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D002648:Child; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D008334:Mandible / Q000473:pathology; D010015:Osteolysis, Essential / Q000188:drug therapy* / Q000473:pathology; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid