title: Association of a progesterone receptor gene +331 G/A polymorphism with breast cancer risk: a meta-analysis.
abstract: Published studies on the association between the progesterone receptor gene +331 G/A polymorphism and breast cancer risk are inconclusive, and meta-analysis is required to verify the association. Six studies, including a total of 6,849 cases and 6,589 controls, were subjected to meta-analysis. When all eligible subjects were pooled for meta-analysis, the AG + AA variant genotype was not associated with a significantly elevated breast cancer risk [odds ratio (OR) = 1.11; 95% confidence interval (95%CI) = 0.99-1.24; P = 0.071]. However, subgroup analysis revealed that the AG + AA variant genotype was associated with an increased risk of breast cancer in American (OR = 1.32; 95%CI = 1.10-1.58; P = 0.003), but not in European or Australian. We could carefully suggest that the progesterone receptor promoter +331 G/A variant polymorphism might increase breast cancer risk, and this effect appeared to be more prominent in Americans than in Europeans and Australians.
authors.affiliation: Department of Radiation Oncology, Medical College, Korea University, Seoul, Korea.
authors.forename: Dae Sik
authors.initials: DS
authors.lastname: Yang
authors.forename: Hwa Jung
authors.initials: HJ
authors.lastname: Sung
authors.forename: Ok Hee
authors.initials: OH
authors.lastname: Woo
authors.forename: Kyong Hwa
authors.initials: KH
authors.lastname: Park
authors.forename: Sang Uk
authors.initials: SU
authors.lastname: Woo
authors.forename: Ae-Ree
authors.initials: AR
authors.lastname: Kim
authors.forename: Eun Sook
authors.initials: ES
authors.lastname: Lee
authors.forename: Jae-Bok
authors.initials: JB
authors.lastname: Lee
authors.forename: Yeul Hong
authors.initials: YH
authors.lastname: Kim
authors.forename: Jun Suk
authors.initials: JS
authors.lastname: Kim
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: Seo
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D011980:Receptors, Progesterone / Q000235:genetics*
chemical_list: D011980:Receptors, Progesterone