Non-invasive evaluation of hepatic fibrosis for type C chronic hepatitis.
OBJECTIVE
The aim of this study was to investigate liver fibrosis using non-invasive Real-time Tissue Elastography (RTE) and transient elastography (FibroScan) methods.


METHODS
RTE, FibroScan and percutaneous liver biopsy were all performed on patients with chronic liver disease, particularly hepatitis C, to investigate liver fibrosis.


RESULTS
FibroScan and RTE were compared for fibrous liver staging (F stage), which was pathologically classified using liver biopsy. In FibroScan, significant differences were observed between F1/F3 and F2/F4, but no such differences were observed between F1/F2, F2/F3 and F3/F4. In RTE, significant differences were observed between F1/F2, F2/F3 and F2/F4. But for F3/F4, no significant differences were observed.


CONCLUSIONS
FibroScan and RTE correlated well with F staging of the liver. In particular RTE was more successful than FibroScan in diagnosing the degree of liver fibrosis.
Tatsumi
Chie
C
Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka-Sayama, Japan.
Kudo
Masatoshi
M
Ueshima
Kazuomi
K
Kitai
Satoshi
S
Ishikawa
Emi
E
Yada
Norihisa
N
Hagiwara
Satoru
S
Inoue
Tatsuo
T
Minami
Yasunori
Y
Chung
Hobyung
H
Maekawa
Kiyoshi
K
Fujimoto
Kenji
K
Kato
Michio
M
Tonomura
Akiko
A
Mitake
Tsuyoshi
T
Shiina
Tsuyoshi
T
D001706:Biopsy; D054459:Elasticity Imaging Techniques / Q000379:methods*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index