title: The role of mTOR signaling in controlling mammalian life span: what a fungicide teaches us about longevity.
authors.affiliation: Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245, USA. sharp@uthscsa.edu
authors.forename: Zelton Dave
authors.initials: ZD
authors.lastname: Sharp
authors.forename: Randy
authors.initials: R
authors.lastname: Strong
mesh_terms: D000375:Aging / Q000378:metabolism / Q000502:physiology; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D049109:Cell Proliferation; D004194:Disease / Q000209:etiology; D004334:Drug Administration Schedule; D005853:Geriatrics / Q000379:methods; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D008136:Longevity / Q000187:drug effects* / Q000502:physiology*; D008659:Metabolic Diseases / Q000209:etiology; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D011322:Primary Prevention / Q000379:methods; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D020123:Sirolimus / Q000008:administration & dosage / Q000494:pharmacology*; D058570:TOR Serine-Threonine Kinases
chemical_list: D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D047908:Intracellular Signaling Peptides and Proteins; C546842:MTOR protein, human; D017346:Protein Serine-Threonine Kinases; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus