title: Contribution of interferon-gamma receptor 1 gene polymorphisms to pre-eclampsia in China.
abstract: OBJECTIVE
  As gene polymorphisms of cytokines receptors have been found to significantly influence cell responses to cytokines, the aim of this study was to test the hypothesis that IFN-gamma receptor 1 (IFNGR1) gene polymorphisms may contribute to the pathogenesis of pre-eclampsia.
  
  
  METHODS
  One hundred and sixty-four pre-eclamptic patients (121 patients with mild pre-eclampsia and 43 patients with severe pre-eclampsia) and 171 controls were included. Polymorphisms of the IFNGR1 gene at positions -611, -270, +56 and +95 were genotyped with the matrix-assisted laser desorption/ionization time of flight mass spectrometry.
  
  
  RESULTS
  This study showed a positive association between -56C/C genotype (OR = 1.7; 95% CI = 1.1-2.7) and pre-eclampsia. Although the genotype frequencies (except for -56C/C) of the two polymorphisms were comparable between cases and controls, higher frequency of the -611A/-56C haplotype (OR = 1.450; 95% CI = 1.070-1.966) was noticed in patients versus controls. All patients and controls were homozygous for the -270T/T and +95T/T genotypes. Specifically, the frequency of the -56C allele (OR = 1.838; 95% CI = 1.127-2.995) was higher among patients with severe pre-eclampsia.
  
  
  CONCLUSIONS
  The IFNGR1 gene polymorphisms may contribute to the pathogenesis of pre-eclampsia in our population.
authors.affiliation: Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
authors.forename: Hao
authors.initials: H
authors.lastname: Zhou
authors.forename: Li
authors.initials: L
authors.lastname: Zou
authors.forename: Ping
authors.initials: P
authors.lastname: Zou
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D017471:Receptors, Interferon / Q000235:genetics*; D000096743:Interferon gamma Receptor
chemical_list: D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor