[Long-term outcome of 52 patients with chronic periaortitis treated with steroids, immunosuppressive therapy and(or) tamoxifen.].
OBJECTIVE
The study aims to assess the therapeutic benefit of medicine treatment in chronic periaortitis.


METHODS
A retrospective study of 52 patients with chronic periaortitis treated at Peking Union Medical College Hospital. Summarize clinical features, level of acute-phase reactants, extent of ureteral obstruction, level of renal function, size of mass with repeated follow-up CT scanning during the period of therapy.


RESULTS
The most prominent symtom was back or abdominal pain. 76.92% had ureteral obstruction, with 26.92% had a progressive renal failure. After a period of treatment, 95.35% were significant to complete resolution of symptoms. There was also a remarkable decrease in ESR and C-reactive protein a median treatment of 4 weeks. Creatinine decreased significantly (P = 0.002) in patients with progressive renal failure. 66.67% was successfully removed the ureteric stents. CT scanning showed 75% mass regression after a median of 6 months.


CONCLUSIONS
The clinical manifestations of chronic periaortitis is nonspecific, which often leads to a delayed diagnosis and the late complications. Chronic periaortitis is very effectively treated by a combination of steroids and immunosuppressive therapy and(or) tamoxifen, with excellent long-term outcome and relatively fewer disease relapse.
Su
Li
L
Department of Rheumatology Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100032, China. Email: zhaoyan_pumch@yahoo.com.cn.
Ren
Ru-Feng
RF
Xue
Hua-Dan
HD
Guo
Xiang-Hua
XH
Feng
Sheng
S
Gou
Li-Juan
LJ
Rong
Shi
S
Tian
Xin-Ping
XP
Zhao
Yan
Y
D002097:C-Reactive Protein; D006801:Humans; D007165:Immunosuppression Therapy; D012185:Retroperitoneal Fibrosis; D012189:Retrospective Studies; D013629:Tamoxifen; D016896:Treatment Outcome
D013629:Tamoxifen; D002097:C-Reactive Protein