title: Anti-inflammatory effect of Acacia visco extracts in animal models.
abstract: The aqueous and organic extracts of Acacia visco Lor. Ap Griseb (Fabaceae) were tested for anti-inflammatory activity in experimental models in rat. Besides, the free-radical scavenging capacity of extracts from A. visco was determined. The extracts revealed anti-inflammatory effect against carrageenan-induced oedema, phospholipase A(2)-induced oedema, cotton pellet-induced granuloma and they did not show acute toxic effect. Among the class of compounds characterized from A. visco leaves, the triterpenoid 20(29)-lupen-3β-ol (lupeol), 12-ursen-3β-ol (α-amyrin) and 12-oleanen-3β-ol (β-amyrin) may be mainly responsible for the pharmacological activities.
authors.affiliation: Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, San Luis, Argentina.
authors.forename: Ana María
authors.initials: AM
authors.lastname: Pedernera
authors.forename: Teresita
authors.initials: T
authors.lastname: Guardia
authors.forename: Carola Elisa Guardia
authors.initials: CE
authors.lastname: Calderón
authors.forename: Alejandra Ester
authors.initials: AE
authors.lastname: Rotelli
authors.forename: Nadir Ernesto
authors.initials: NE
authors.lastname: de la Rocha
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Saad
authors.forename: María Alejandra Lopez
authors.initials: MA
authors.lastname: Verrilli
authors.forename: Susana Garcia
authors.initials: SG
authors.lastname: Aseff
authors.forename: Lilian Eugenia
authors.initials: LE
authors.lastname: Pelzer
mesh_terms: D000045:Acacia; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000633:toxicity; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D006099:Granuloma / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D051379:Mice; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D053978:Pentacyclic Triterpenes / Q000627:therapeutic use*; D054467:Phospholipases A2; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D000094042:Lupanes
chemical_list: D000893:Anti-Inflammatory Agents; D002351:Carrageenan; D009828:Oleanolic Acid; D053978:Pentacyclic Triterpenes; D054467:Phospholipases A2; D010936:Plant Extracts; C036380:beta-amyrin; C010480:lupeol; D000094042:Lupanes