Synthesis and antiviral activity of scopadulane-rearranged diterpenes.
A new bioactive diterpene skeleton resulting from a backbone rearrangement is described. Activity of the rearranged product and several derivatives against Herpes Virus Simplex type 2 is reported.
González
Miguel A
MA
Departamento de Química Orgánica, Universidad de Valencia, Dr Moliner 50, E-46100 Burjassot, Valencia, Spain. miguel.a.gonzalez@uv.es <miguel.a.gonzalez@uv.es>
Agudelo
Lee
L
Betancur-Galvis
Liliana
L
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D014709:Vero Cells; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D004224:Diterpenes