title: Calicheamicin γ1(I) and phenyl tert-butyl nitrone (PBN): observation of a kinetic isotope effect by an ESR study.
abstract: ESR study of enediyne calicheamicin gamma(1)(I) with phenyl tert-butyl nitrone (PBN) gave a significant kinetic isotope effect (k(H)/k(D) = 1.8) for the formation of the phenyl radical PBN monoadducts.
authors.affiliation: Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan. t-usuki@sophia.ac.jp
authors.forename: Toyonobu
authors.initials: T
authors.lastname: Usuki
authors.forename: Mari
authors.initials: M
authors.lastname: Kawai
authors.forename: Koji
authors.initials: K
authors.lastname: Nakanishi
authors.forename: George A
authors.initials: GA
authors.lastname: Ellestad
mesh_terms: D000617:Aminoglycosides / Q000737:chemistry*; D003497:Cyclic N-Oxides / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D053281:Enediynes / Q000737:chemistry*; D007700:Kinetics; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D000617:Aminoglycosides; D003497:Cyclic N-Oxides; D053281:Enediynes; C055955:calicheamicin gamma(1)I; C029217:phenyl-N-tert-butylnitrone