title: Fifteen years of APC/cyclosome: a short and impressive biography.
abstract: The APC/C (anaphase-promoting complex/cyclosome) discovered exactly 15 years ago by Avram Heshko and Marc Kirschner is by far the most complex ubiquitin ligase discovered so far. The APC/C is composed of roughly a dozen subunits and measures a massive 1.5 MDa. This huge complex, as well as its multiple modes of regulation, boasts impressive evolutionary conservation. One of its most puzzling features is its split personality: regulation of mitotic exit events on the one hand, and its ongoing activity during G(1)-phase, G(0)-phase and in terminally differentiated cells. The present short review is intended to provide a basic description of our current understanding of the APC/C, focusing on recent findings concerning its role in G(1)-phase and in differentiated cells.
authors.affiliation: Department of Genetics, The Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel.
authors.forename: Kobi J
authors.initials: KJ
authors.lastname: Simpson-Lavy
authors.forename: Yifat S
authors.initials: YS
authors.lastname: Oren
authors.forename: Oren
authors.initials: O
authors.lastname: Feine
authors.forename: Julia
authors.initials: J
authors.lastname: Sajman
authors.forename: Tammy
authors.initials: T
authors.lastname: Listovsky
authors.forename: Michael
authors.initials: M
authors.lastname: Brandeis
mesh_terms: D000595:Amino Acid Sequence; D064173:Anaphase-Promoting Complex-Cyclosome; D002453:Cell Cycle / Q000502:physiology; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D013379:Substrate Specificity; D043743:Ubiquitin-Protein Ligase Complexes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D021122:Protein Subunits; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome