Potential of stratus optical coherence tomography for detecting early glaucoma in perimetrically normal eyes of open-angle glaucoma patients with unilateral visual field loss.
OBJECTIVE
To evaluate the potential of stratus optical coherence tomography (OCT) for detecting early glaucoma.


METHODS
Fifty-two open-angle glaucoma patients with unilateral visual field loss detected by standard automatic perimetry were tested using stratus OCT and frequency doubling technology (FDT) N-30. Fifty-two perimetrically normal eyes were enrolled and divided into 2 groups: eyes with normal OCT results and eyes with abnormal OCT results. FDT parameters and scores were compared between the 2 groups. We evaluated the topographic relationship of the OCT-measured retinal nerve fiber layer (RNFL) defects with the FDT-measured visual field loss and glaucomatous optic neuropathy.


RESULTS
In eyes with abnormal OCT results, the percentage of eyes with abnormal FDT results was significantly higher (P<0.001); FDT mean deviation, pattern standard deviation, and scores were significantly worse than those with normal OCT results (P=0.005, P<0.001, P<0.001, respectively); and the OCT-measured RNFL defects showed good topographic agreement with the FDT-measured visual field loss and glaucomatous optic neuropathy.


CONCLUSIONS
RNFL defects detected by stratus OCT were associated with FDT visual field loss. Stratus OCT can detect early glaucoma sooner than standard automatic perimetry.
Zhang
Yu
Y
Peking University Third Hospital, Peking University Eye Center, Beijing, China.
Wu
Ling-Ling
LL
Yang
Yan-Fang
YF
D000328:Adult; D000368:Aged; D042241:Early Diagnosis; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D057066:Low Tension Glaucoma / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D014786:Vision Disorders / Q000175:diagnosis*; D058609:Visual Field Tests; D014794:Visual Fields; D055815:Young Adult