[Comparative study on different anti-adhesion agents in preventing tubal obstruction after interventional recanalization.].
OBJECTIVE
To study the efficacy of different anti-adhesion agents used in preventing tubal obstruction after recanalization.


METHODS
Five hundred and eight patients with tubal obstruction were divided into 245 cases in control group, 108 cases in chitosan group; 113 cases in sodium hyaluronate group and 42 cases in lipiodol group. The patients in control group were injected with anti-inflammation agents after recanalization, while other groups were injected with chitosan, sodium hyaluronate or lipiodol at dose of 2 - 3 ml in every therapeutic group. The rate of location of tubal obstruction and tubal recanalization were recorded during operation. Then patients in every group were followed up on tubal patency after 3 months, and pregnancy rate after 12 months.


RESULTS
Among 1016 fallopian tubes in 508 patients, there were 330 tubes occlusion at isthmus portion and 563 tubes occlusion at interstitial portion of fallopian tube. Thirty-seven fallopian tubes were ablated because of ectopic pregnancy, 86 fallopian tubes were unobstructed. (1) The recanalization rate were 95.7% (179/187) in chitosan group, 97.9% (191/195) in sodium hyaluronate group, 98.7% (75/76) in lipiodol group and 97.7% (425/435) in control group, which did not show statistical difference (P > 0.05). (2) The rates of tubal patency after 3 months of 91.7% (99/108) in chitosan group and 88.5% (100/113) in sodium hyaluronate group were significantly higher than 71.4% (30/42) in lipiodol group and 74.3% (182/245) in control group (P < 0.05). (3) The rates of intrauterine pregnancy after 12 months were 48.1% (52/108) in chitosan group and 41.6% (47/113) in sodium hyaluronate group, which were significantly higher than 23.8% (10/42) in lipiodol group and 24.1% (59/245) in control group (P < 0.05).


CONCLUSIONS
Chitosan and sodium hyaluronate could be effective to prevent tubal obstruction after interventional recanalization and increase pregnancy rate.
Huang
Yi
Y
Department of Radiology, Panyu People's Hospital, Guangzhou 511400, China. Email: hy35493@163.com.
Guo
Zhen-Zhen
ZZ
Chen
Han-Wei
HW
Liang
Wei-Hua
WH
Xu
Yan
Y
Yang
Li
L
Liang
Zhi-Tao
ZT
Wu
Xing-Jie
XJ
He
Li
L
D000818:Animals; D005184:Fallopian Tube Diseases / Q000601:surgery; D005187:Fallopian Tubes / Q000601:surgery; D006801:Humans; D007047:Hysterosalpingography; D018873:Pregnancy Rate; D013246:Sterilization, Tubal