title: [Update on the management of severe traumatic brain injury].
abstract: Prognosis after severe traumatic brain injury (TBI) is determined by the severity of initial injury and secondary cerebral damage. The main determinants of secondary cerebral damage are brain ischemia and oedema. Traumatic brain injury is a heterogeneous disease. Head CT-scan is essential in evaluating initial type of injury and severity of brain oedema. A standardised approach based on prevention and treatment of secondary cerebral damage is the only effective therapeutic strategy of severe TBI. We review the classification, pathophysiology and treatment of secondary cerebral damage after severe TBI and discuss the management of intracranial hypertension, cerebral perfusion pressure and brain ischemia.
authors.affiliation: Service de médecine intensive adulte, Département des centres interdisciplinaires et logistique médicale, CHUV, 1011 Lausanne. mauro.oddo@chuv.ch
authors.forename: Mauro
authors.initials: M
authors.lastname: Oddo
authors.forename: Yvan
authors.initials: Y
authors.lastname: Gasche
mesh_terms: D001930:Brain Injuries / Q000628:therapy*; D006801:Humans; D015601:Injury Severity Score