title: Role of the transcription factor NFIC in odontoblast gene expression.
abstract: The transcription factor NFI-C is essential for root development. Mice lacking NFI-C develop abnormal roots and lose their teeth, resembling radicular dentin dysplasia I in humans. The purpose of this study was to understand the role of NFI-C in dentinogenesis. The authors found statistically significant increases in the expression of several mRNAs in cells lacking NFI-C, suggesting that these molecules might interfere with odontoblast cell migration and differentiation, and consequently with root development.
authors.affiliation: University of Southern California, School of Dentistry, Los Angeles, USA.
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Kim
authors.forename: Julia
authors.initials: J
authors.lastname: Reyna
authors.forename: Li-Sha
authors.initials: LS
authors.lastname: Chen
authors.forename: Maggie
authors.initials: M
authors.lastname: Zeichner-David
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D002465:Cell Movement / Q000235:genetics; D003810:Dentinogenesis / Q000235:genetics*; D004195:Disease Models, Animal; D015870:Gene Expression / Q000235:genetics*; D051379:Mice; D051839:NFI Transcription Factors / Q000235:genetics*; D009804:Odontoblasts / Q000502:physiology*; D009805:Odontogenesis / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D014092:Tooth Root / Q000502:physiology
chemical_list: D051839:NFI Transcription Factors; C497648:Nfic protein, mouse; D012333:RNA, Messenger