Clinical implications of adiponectin and inflammatory biomarkers in type 2 diabetes mellitus.
OBJECTIVE
To study the interrelationships of adiponectin, C-reactive protein (CRP) and fibrinogen with each other in T2DM patients with (T2DM-C) and without complications (T2DM-NC) among healthy individuals.


METHODS
The study comprised of 120 T2DM-C, 59 T2DM-NC patients and 40 healthy volunteers. Biochemical markers were determined in the serum.


RESULTS
Positivity rates of CRP and fibrinogen were significantly increased in T2DM-C as compared to T2DM-NC or controls, whereas adiponectin showed highest level in healthy individuals. Inflammatory biomarkers were inversely correlated with adiponectin (P< 0.01). Lipid profiles, kidney functions and BMI, showed positive significant correlation with CRP and fibrinogen but negative correlation with adiponectin. For better detection of T2DM, the combined sensitivity (98.9%) and specificity (92.5%) of fibrinogen and adiponectin was higher than the combined sensitivity and specificity of fibrinogen and CRP or adiponectin and CRP or than that of the biomarkers alone.


CONCLUSIONS
Elevated levels of CRP and fibrinogen and reduced level of adiponectin can be used for early diagnosis of T2DM and can predict diabetic complications.
Swellam
Menha
M
Department of Biochemistry, National Research Center, Dokki, Giza, Egypt. menha_m_swellam@hotmail.com
Sayed Mahmoud And
Magda
M
Abdel-Fatah Ali
Adel
A
D052242:Adiponectin / Q000096:biosynthesis / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000097:blood; D007668:Kidney / Q000503:physiopathology; D054020:Lasers, Gas; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014652:Vascular Diseases / Q000209:etiology / Q000378:metabolism
D052242:Adiponectin; D015415:Biomarkers; D008055:Lipids; D005340:Fibrinogen; D002097:C-Reactive Protein