Targeting multiple biofilm pathways.
Cegelski et al. (2009) demonstrate the importance of amyloid production for biofilm formation and host colonization using several mutant strains of pathogenic E. coli and small molecule inhibitors. This work reveals a path forward for studying the role of bacterial amyloids in vivo and suggests the potential for small molecules to target multiple biofilm formation pathways.
Hett
Erik C
EC
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Hung
Deborah T
DT
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development*; D004195:Disease Models, Animal; D010861:Fimbriae, Bacterial / Q000737:chemistry / Q000378:metabolism; D051379:Mice; D053038:Quorum Sensing; D056689:Uropathogenic Escherichia coli / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C077481:Crl protein, Bacteria