title: Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model.
abstract: Curcumin can decrease viable cells through the induction of apoptosis in human lung cancer NCI-H460 cells in vitro. However, there are no reports that curcumin can inhibit cancer cells in vivo. In this study, NCI-H460 lung tumour cells were implanted directly into nude mice and divided randomly into four groups to be treated with vehicle, curcumin (30 mg/kg of body weight), curcumin (45 mg/kg of body weight) and doxorubicin (8 mg/kg of body weight). Each agent was injected once every 4 days intraperitoneally (i.p.), with treatment starting 4 weeks after inoculation with the NCI-H460 cells. Treatment with 30 mg/kg and 45 mg/kg of curcumin or with 8 mg/kg of doxorubicin resulted in a reduction in tumour incidence, size and weight compared with the control group. The findings indicate that curcumin can inhibit tumour growth in a NCI-H460 xenograft animal model in vivo.
authors.affiliation: Division of General Surgery, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien 970, Taiwan.
authors.forename: Chin-Cheng
authors.initials: CC
authors.lastname: Su
authors.forename: Jai-Sing
authors.initials: JS
authors.lastname: Yang
authors.forename: Chi-Cheng
authors.initials: CC
authors.lastname: Lu
authors.forename: Jo-Hua
authors.initials: JH
authors.lastname: Chiang
authors.forename: Chang-Lin
authors.initials: CL
authors.lastname: Wu
authors.forename: Jen-Jyh
authors.initials: JJ
authors.lastname: Lin
authors.forename: Kuang-Chi
authors.initials: KC
authors.lastname: Lai
authors.forename: Te-Chun
authors.initials: TC
authors.lastname: Hsia
authors.forename: Hsu-Feng
authors.initials: HF
authors.lastname: Lu
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Fan
authors.forename: Jing-Gung
authors.initials: JG
authors.lastname: Chung
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D018287:Carcinoma, Large Cell / Q000188:drug therapy*; D045744:Cell Line, Tumor; D003474:Curcumin / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D023041:Xenograft Model Antitumor Assays
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004317:Doxorubicin; D003474:Curcumin