Pheochromocytoma in children and adolescents.
Eleven subjects aged <20 yr with histologically proven pheochromocytoma between 1987 and 2006 were analyzed. Family history was present in 18%. In 2 patients, pheochromocytoma was part of VHL and in one it was associated with MEN 2. Twenty four hour urine VMA level was elevated in 100% and metanephrine level in 73%. CT/ MRI were showing the tumor in all. Prazosin extended release tablets (maximum 30 mg/day) were used in 73% and doxazosin (maximum 12 mg/ day) in 27%. Intraoperative BP fluctuations were seen in 27%. All were biochemically cured after surgery. Preoperative á blockade with extended release prazosin and doxazosin were effective in controlling perioperative BP fluctuations. Hence these drugs can be used in children and adolescents without fear of postoperative hypotension.
Ganesh
H K
HK
Department of Endorinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India.
Acharya
Shrikrishna V
SV
Goerge
Joe
J
Bandgar
Tushar R
TR
Menon
Padma S
PS
Shah
Nalini S
NS
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery; D000315:Adrenalectomy; D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D002648:Child; D017292:Doxazosin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology; D007431:Intraoperative Complications / Q000517:prevention & control; D008297:Male; D010673:Pheochromocytoma / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery; D011224:Prazosin / Q000627:therapeutic use; D016896:Treatment Outcome
D000317:Adrenergic alpha-Antagonists; D017292:Doxazosin; D011224:Prazosin