Decreased serum levels of adiponectin in subjects with autism.
The neurobiological basis for autism remains poorly understood. We hypothesized that adipokines, such as adiponectin, may play a role in the pathophysiology of autism. In this study, we examined whether serum levels of adiponectin are altered in subjects with autism. We measured serum levels of adiponectin in male subjects with autism (n=31) and age-matched healthy male subjects (n=31). The serum levels of adiponectin in the subjects with autism were significantly lower than that of normal control subjects. The serum adiponectin levels in the subjects with autism were negatively correlated with their domain A scores in the Autism Diagnostic Interview-Revised, which reflects their impairments in social interaction. This study suggests that decreased levels of serum adiponectin might be implicated in the pathophysiology of autism.
Fujita-Shimizu
Azusa
A
Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.
Suzuki
Katsuaki
K
Nakamura
Kazuhiko
K
Miyachi
Taishi
T
Matsuzaki
Hideo
H
Kajizuka
Masanobu
M
Shinmura
Chie
C
Iwata
Yasuhide
Y
Suda
Shiro
S
Tsuchiya
Kenji J
KJ
Matsumoto
Kaori
K
Sugihara
Genichi
G
Iwata
Keiko
K
Yamamoto
Shigeyuki
S
Tsujii
Masatsugu
M
Sugiyama
Toshiro
T
Takei
Nori
N
Mori
Norio
N
D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D001321:Autistic Disorder / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D013223:Statistics as Topic; D055815:Young Adult
D052242:Adiponectin