title: [Expression of adhension molecule CD146 in renal tubular epithelial cells and its clinical significance in IgA nephropathy].
abstract: OBJECTIVE
  To detect the expression of adhension molecule CD146 in renal tubular epithelial cells and its clinical significance in IgA nephropathy.
  
  
  METHODS
  The expression level of CD146 was measured by immunochemistry method in serial sections of 44 specimens from the patients with biopsy-proven IgA nephropathy. The relationship between CD146 expression and clinicopathological changes was analyzed.
  
  
  RESULTS
  CD146 was mainly expressed in renal tubular epithelial cells, also slightly in the endothelial cells of peritubular capillary and smooth muscle cells. The expression of CD146 had no relationship with Lee's grade of IgA nephropathy, but positively correlated with 24-hour urine protein(r = 0.381, P = 0.011), hypertention, serum creatinine, triglyceride (Z = -2.738, -2.166, - 2.313, P = 0.006, 0.030, 0.021), index of glomerular sclerosis (r = 0 410, P = 0.006), degree of interstitial fibrosi s (r = 0.311, P = 0.040).
  
  
  CONCLUSIONS
  CD146 might play an important role in the progression of renal interstitial fibrosis.
authors.affiliation: Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Ji
authors.forename: Gui-Ming
authors.initials: GM
authors.lastname: Wu
authors.forename: Li-Chuan
authors.initials: LC
authors.lastname: Yang
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Huan
authors.initials: H
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D051929:CD146 Antigen / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism*; D005260:Female; D005922:Glomerulonephritis, IGA / Q000378:metabolism*; D006801:Humans; D007684:Kidney Tubules / Q000166:cytology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D051929:CD146 Antigen; C497902:MCAM protein, human