title: Classification models for early identification of persons at risk for dementia in primary care: an evaluation in a sample aged 80 years and older.
abstract: OBJECTIVE
  To evaluate previously developed classification models to make implementation in primary care possible and aid early identification of persons at risk for dementia.
  
  
  METHODS
  Data were drawn from the OCTO-Twin study. At baseline, 521 persons >or= 80 years of age were nondemented, and for 387 a blood sample was available. Predictors of dementia were collected and analyzed in initially nondemented persons using generalized estimating equations and Cox survival analyses.
  
  
  RESULTS
  In the basic model using predictors already known or easily obtained (basic set), the mean 2-year predictive value increased from 6.9 to 28.8% in persons with memory complaints and an MMSE score <or= 25. In the extended model, using both the basic set and an extended set of predictors requiring further assessment, the 8-year predictive value increased from 15.0 to 45.8% in persons with low cholesterol and an MMSE score <or= 24.
  
  
  CONCLUSIONS
  Both models can contribute to an improved early identification of persons at risk for dementia in primary care.
authors.affiliation: Longitudinal Aging Study Amsterdam and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands. tn.vandenkommer @ vumc.nl
authors.forename: Tessa N
authors.initials: TN
authors.lastname: van den Kommer
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Bontempo
authors.forename: Hannie C
authors.initials: HC
authors.lastname: Comijs
authors.forename: Scott M
authors.initials: SM
authors.lastname: Hofer
authors.forename: Miranda G
authors.initials: MG
authors.lastname: Dik
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Piccinin
authors.forename: Cees
authors.initials: C
authors.lastname: Jonker
authors.forename: Dorly J H
authors.initials: DJ
authors.lastname: Deeg
authors.forename: Boo
authors.initials: B
authors.lastname: Johansson
mesh_terms: D000369:Aged, 80 and over / Q000523:psychology*; D000428:Alcohol Drinking / Q000453:epidemiology; D015415:Biomarkers; D003362:Cost-Benefit Analysis; D003627:Data Interpretation, Statistical; D003704:Dementia / Q000145:classification* / Q000175:diagnosis* / Q000191:economics; D003863:Depression / Q000523:psychology; D003920:Diabetes Mellitus / Q000523:psychology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000523:psychology; D015233:Models, Statistical; D009483:Neuropsychological Tests; D011320:Primary Health Care; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D018570:Risk Assessment / Q000145:classification* / Q000379:methods / Q000706:statistics & numerical data; D012907:Smoking / Q000523:psychology; D013548:Sweden / Q000453:epidemiology; D018433:Twin Studies as Topic
chemical_list: D015415:Biomarkers