The effect of repetitive transcranial magnetic stimulation on a model rat of Parkinson's disease.
This study was undertaken to investigate the neuroprotective effects of repetitive transcranial magnetic stimulation (rTMS) on 6-hydroxydopamine (6-OHDA)-induced rats with Parkinson's disease. rTMS was given to rats with Parkinson's disease induced by 6-OHDA, daily for 4 weeks to examine the protective effects. Rotational test showed that rTMS significantly attenuated apomorphine-induced turns in rats with Parkinson's disease. Tissue processing showed that rTMS alleviated 6-OHDA-induced loss of dopaminergic neurons in rat substantia nigra. Furthermore, rTMS decreased the levels of cyclooxygenase-2 and tumor necrosis factor-alpha in rat substantia nigra, and prevented the fall of dopamine in the striatum of rats with Parkinson's disease.
Yang
Xinxin
X
Department of Neurology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Song
Lu
L
Liu
Zhenguo
Z
D000818:Animals; D002853:Chromatography, Liquid; D003342:Corpus Striatum / Q000378:metabolism*; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D018492:Dopamine Antagonists; D005260:Female; D008845:Microinjections; D009474:Neurons / Q000378:metabolism*; D016627:Oxidopamine; D010300:Parkinson Disease / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013378:Substantia Nigra / Q000378:metabolism*; D050781:Transcranial Magnetic Stimulation; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D018492:Dopamine Antagonists; D014409:Tumor Necrosis Factor-alpha; D016627:Oxidopamine; D051546:Cyclooxygenase 2; D004298:Dopamine