title: New neo-clerodane diterpenoids from Scutellaria barbata with cytotoxic activities.
abstract: Two new neo-clerodane diterpenoids have been isolated from the whole plant of Scutellaria barbata D. Don, and their structures were established by detailed spectral analyses as scutehenanine H (1) and 6-(2,3-epoxy-2-isopropyl-n-propoxyl)barbatin C (2). In vitro, the isolated two new compounds showed significant cytotoxic activities against three human cancer lines, and gave IC(50) values in the range OF 2.0-4.2 μΜ.
authors.affiliation: School of Pharmaceutical Science, Yantai University, Yantai 264005, PR China. daishengjun_9@hotmail.com
authors.forename: Sheng-Jun
authors.initials: SJ
authors.lastname: Dai
authors.forename: Gui-Wu
authors.initials: GW
authors.lastname: Qu
authors.forename: Qun-Ying
authors.initials: QY
authors.lastname: Yu
authors.forename: De-Wu
authors.initials: DW
authors.lastname: Zhang
authors.forename: Gui-Sheng
authors.initials: GS
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D045785:Diterpenes, Clerodane / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D031363:Scutellaria / Q000737:chemistry*
chemical_list: C557238:6-(2,3-epoxy-2-isopropyl-n-propoxyl)barbatin; D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane; D010936:Plant Extracts; C557237:scutehenanine H