title: Dietary fat and early-onset prostate cancer risk.
abstract: The UK incidence of prostate cancer has been increasing in men aged < 60 years. Migrant studies and global and secular variation in incidence suggest that modifiable factors, including a high-fat diet, may contribute to prostate cancer risk. The aim of the present study was to investigate the role of dietary fat intake and its derivatives on early-onset prostate cancer risk. During 1999-2004, a population-based case-control study with 512 cases and 838 controls was conducted. Cases were diagnosed with prostate cancer when < or = 60 years. Controls were sourced from UK GP practice registers. A self-administered FFQ collected data on typical past diet. A nutritional database was used to calculate daily fat intake. A positive, statistically significant risk estimate for the highest v. lowest quintile of intake of total fat, SFA, MUFA and PUFA was observed when adjusted for confounding variables: OR 2.53 (95 % CI 1.72, 3.74), OR 2.49 (95 % CI 1.69, 3.66), OR 2.69 (95 % CI 1.82, 3.96) and OR 2.34 (95 % CI 1.59, 3.46), respectively, with all P for trend < 0.001. In conclusion, there was a positive statistically significant association between prostate cancer risk and energy-adjusted intake of total fat and fat subtypes. These results potentially identify a modifiable risk factor for early-onset prostate cancer.
authors.affiliation: University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK. alopha2003@yahoo.co.uk
authors.forename: Artitaya
authors.initials: A
authors.lastname: Lophatananon
authors.forename: Jane
authors.initials: J
authors.lastname: Archer
authors.forename: Douglas
authors.initials: D
authors.lastname: Easton
authors.forename: Richard
authors.initials: R
authors.lastname: Pocock
authors.forename: David
authors.initials: D
authors.lastname: Dearnaley
authors.forename: Michelle
authors.initials: M
authors.lastname: Guy
authors.forename: Zsofia
authors.initials: Z
authors.lastname: Kote-Jarai
authors.forename: Lynne
authors.initials: L
authors.lastname: O'Brien
authors.forename: Rosemary A
authors.initials: RA
authors.lastname: Wilkinson
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Hall
authors.forename: Emma
authors.initials: E
authors.lastname: Sawyer
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Page
authors.forename: Jo-Fen
authors.initials: JF
authors.lastname: Liu
authors.forename: Sandra
authors.initials: S
authors.lastname: Barratt
authors.forename: Aneela A
authors.initials: AA
authors.lastname: Rahman
authors.forename: Rosalind
authors.initials: R
authors.lastname: Eeles
authors.forename: Kenneth
authors.initials: K
authors.lastname: Muir
mesh_terms: D016022:Case-Control Studies; D004034:Diet Surveys; D004041:Dietary Fats / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity; D016017:Odds Ratio; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000209:etiology*; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D004041:Dietary Fats