title: Pathogen incidence and antibiotic resistance patterns of catheter-associated urinary tract infection in children.
abstract: The aim of this study was to characterize the pathogens and their antibiotic susceptibilities in children with catheter-associated urinary tract infection (CAUTI) in order to optimize empirical antibiotic therapy and prophylaxis. from 2001 to 2006, 895 children with an indwelling catheter from 3 hospitals in China were included in this study, of whom 335 (37.4%) had CAUTI. Antimicrobial susceptibility testing of 450 bacterial isolates was performed using the ClSi broth and Kirby-bauer agar dilution methods. Escherichia coli was the most frequently isolated pathogen, followed by Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus spp. E. coli had higher susceptibility to ceftazidime (87.4%), cefuroxime (85.1%) and cefatrizine (76.6%) than to sulfamethoxazole (SMZ) (8.0%), amoxicillin (21.7%), ampicillin (17.1%) and cefazolin (37.7%). Isolates of Klebsiella pneumoniae and Proteus species had similar patterns as E. coli. S. aureus had lower susceptibility to SmZ (6.8%), ampicillin (8.2%), and amoxicillin (24.7%); the trend of S. epidermidis was similar. This study demonstrates that the Gram-negative species are the predominating uropathogens of CAUti in children. it is important to know the bacterial spectrum and the susceptibility patterns to various classes of antibiotic agents to improve empiric antibiotic therapy of children with CAUTI in China.
authors.affiliation: Southern Medical University, Guangzhou, China.
authors.forename: Xue-Cheng
authors.initials: XC
authors.lastname: Bi
authors.forename: Binghua
authors.initials: B
authors.lastname: Zhang
authors.forename: Yong-Kang
authors.initials: YK
authors.lastname: Ye
authors.forename: Hui-Chan
authors.initials: HC
authors.lastname: He
authors.forename: Zhao-Dong
authors.initials: ZD
authors.lastname: Han
authors.forename: Qi-Shan
authors.initials: QS
authors.lastname: Dai
authors.forename: Yu-Xiang
authors.initials: YX
authors.lastname: Liang
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Zeng
authors.forename: Yue-Sheng
authors.initials: YS
authors.lastname: Wang
authors.forename: Qing-Biao
authors.initials: QB
authors.lastname: Chen
authors.forename: Wei-De
authors.initials: WD
authors.lastname: Zhong
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D055499:Catheter-Related Infections / Q000188:drug therapy / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004352:Drug Resistance, Microbial; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D014546:Urinary Catheterization / Q000009:adverse effects*; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents