title: Effects of chronic exposure to octylphenol on the male rat reproductive system.
abstract: p-tert-Octylphenol (OP) is a degradation product of alkylphenol ethoxylates. OP is an endocrine disruptor known to bind to the estrogen receptor; however, effects on males are controversial. The objective of this study was to evaluate the effects of chronic exposure to OP on male reproduction. Adult Sprague-Dawley rats were administered OP for 60 d, representing 1.5 cycles of spermatogenesis. Experimental groups included a vehicle control, and three doses of OP (25, 50, or 125 mg/kg body weight [bw]) administered daily by gavage. There was a significant decrease in body weight in the 125-mg/kg group after 60 d of treatment. Both testicular and epididymal weights and histology were not altered by treatment with OP at any of the doses administered. There were no marked differences in cauda epididymal sperm counts at any doses; however, total percent sperm motility was significantly lower in rats exposed to the intermediate dose (50 mg/kg bw). There was an increase in percent static sperm cells in all OP-treated groups, with the intermediate dose (50 mg/kg) displaying a significantly higher proportion of static cells relative to untreated controls. Caput epididymal sperm motility was unaltered by OP treatment. Gene expression profiles of testes from control and high-dose-exposed rats indicate that 14 genes were modulated by at least twofold, although these changes were not statistically significant. Taken together, results from this study indicate that OP treatment of adult rats does not appear to exert major effects on male reproductive endpoints at relevant environmental exposure doses.
authors.affiliation: INRS-Institut Armand-Frappier, Université du Québec, Québec, Canada.
authors.forename: Mary
authors.initials: M
authors.lastname: Gregory
authors.forename: Alexandra
authors.initials: A
authors.lastname: Lacroix
authors.forename: Sami
authors.initials: S
authors.lastname: Haddad
authors.forename: Patrick
authors.initials: P
authors.lastname: Devine
authors.forename: Michel
authors.initials: M
authors.lastname: Charbonneau
authors.forename: Robert
authors.initials: R
authors.lastname: Tardif
authors.forename: Kannan
authors.initials: K
authors.lastname: Krishnan
authors.forename: Gerard M
authors.initials: GM
authors.lastname: Cooke
authors.forename: Timothy
authors.initials: T
authors.lastname: Schrader
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Cyr
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004785:Environmental Pollutants / Q000008:administration & dosage* / Q000633:toxicity*; D004822:Epididymis / Q000187:drug effects; D008297:Male; D010636:Phenols / Q000008:administration & dosage* / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012661:Semen / Q000187:drug effects; D013076:Sperm Count; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects
chemical_list: D004785:Environmental Pollutants; D010636:Phenols; C474055:octylphenol