Thyroid dysfunction and autoantibodies during pregnancy as predictive factors of pregnancy complications and maternal morbidity in later life.
BACKGROUND
Knowledge is scarce concerning the significance of thyroid dysfunction/antibodies during pregnancy in regard to pregnancy complications/later maternal morbidity.


OBJECTIVE
The aim of this study was to evaluate the association between maternal thyroid dysfunction/antibodies during pregnancy and pregnancy complications or later maternal hypertension, diabetes, and thyroid disease.


METHODS
We studied a prospective population-based cohort, Northern Finland Birth Cohort 1986 (NFBC 1986), with follow-up of 20 yr. Medication and hospital discharge records were used to assess maternal morbidity to hypertension, diabetes, and thyroid diseases.


METHODS
The study consisted of mothers of NFBC 1986 with early pregnancy serum samples for thyroid function and antibody analyses (n = 5805). Mothers were grouped and compared according to these test results.


METHODS
We focused on preeclampsia and gestational diabetes during index pregnancy, later maternal hypertension, diabetes, and thyroid disease morbidity and total mortality.


RESULTS
Thyroid dysfunction and antibodies were not associated with pregnancy complications. Overt hypothyroidism was associated with subsequent maternal thyroid disease [hazard ratio (HR) (95% confidence interval), 17.7 (7.8-40.6)] and diabetes [6.0 (2.2-16.4)]. Subclinical hypothyroidism [3.3 (1.6-6.9)], TPO-Ab-positivity [4.2 (2.3-7.4)], and TG-Ab-positivity [3.3 (1.9-6.0)] were also associated with later thyroid disease. No association was found between thyroid dysfunction/antibodies and hypertension or overall mortality.


CONCLUSIONS
Thyroid dysfunction and antibodies during pregnancy seem to predict later thyroid disease. Overt hypothyroidism poses risk of diabetes.
Männistö
Tuija
T
Department of Obstetrics and Gynecology, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland.
Vääräsmäki
Marja
M
Pouta
Anneli
A
Hartikainen
Anna-Liisa
AL
Ruokonen
Aimo
A
Surcel
Heljä-Marja
HM
Bloigu
Aini
A
Järvelin
Marjo-Riitta
MR
Suvanto
Eila
E
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001323:Autoantibodies / Q000097:blood*; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000209:etiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications; D011446:Prospective Studies; D012044:Regression Analysis; D011795:Surveys and Questionnaires; D013959:Thyroid Diseases / Q000097:blood* / Q000209:etiology*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D001323:Autoantibodies; D014284:Triiodothyronine; D013974:Thyroxine