Effects of structural differences between radioiodine-labeled 1-(2'-fluoro-2'-deoxy-D-arabinofuranosyl)-5-iodouracil (FIAU) and 1-(2'-fluoro-2'-deoxy-d-ribofuranosyl)-5-iodouracil (FIRU) on HSV1-TK reporter gene imaging.
The goal of this investigation was to evaluate the effects of structural differences between FIAU and FIRU on their ability to serve as a potential tracer for reporter gene imaging. To examine the characteristics of different configurations of FIAU and FIRU, a series of evaluations were done on HSV1-TK gene-expressing cells and on mice with HSV1-TK gene-expressing tumor. The results showed that, as an imaging agent for HSV1-TK-expressing cells, radiolabeled FIAU was more efficient for in vivo imaging than FIRU.
Kim
Eun Jung
EJ
Radiopharmaceutical Research Team, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Republic of Korea.
Hong
Su Hee
SH
Choi
Tae Hyun
TH
Lee
Eun Ah
EA
Kim
Kyeong Min
KM
Lee
Kyo Chul
KC
An
Gwang Il
GI
El-Gamal
Mohammed I
MI
Cheon
Gi Jeong
GJ
Choi
Chang Woon
CW
Lim
Sang Moo
SM
D000818:Animals; D001086:Arabinofuranosyluracil / Q000031:analogs & derivatives* / Q000378:metabolism; D005467:Floxuridine / Q000031:analogs & derivatives / Q000378:metabolism; D017930:Genes, Reporter; D018259:Herpesvirus 1, Human / Q000201:enzymology*; D007457:Iodine Radioisotopes; D051379:Mice; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics*
D007457:Iodine Radioisotopes; D014764:Viral Proteins; D005467:Floxuridine; D001086:Arabinofuranosyluracil; C043457:fialuridine; C059970:5-iodo-1-(2-fluoro-2-deoxyribofuranosyl)uracil; D011505:Protein-Tyrosine Kinases