title: Fluorescence properties and cellular distribution of the investigational anticancer drug triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex.
abstract: Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), which entered several phase I and II clinical trials as an antitumor chemotherapeutic agent, was found to possess intrinsic fluorescence properties (lambda(ex) = 360 nm), which enabled us to monitor the uptake and intracellular distribution in living human cancer cells by fluorescence microscopy.
authors.affiliation: University of Vienna, Institute of Inorganic Chemistry, Währingerstr. 42, A-1090, Vienna, Austria.
authors.forename: Christian R
authors.initials: CR
authors.lastname: Kowol
authors.forename: Robert
authors.initials: R
authors.lastname: Trondl
authors.forename: Vladimir B
authors.initials: VB
authors.lastname: Arion
authors.forename: Michael A
authors.initials: MA
authors.lastname: Jakupec
authors.forename: Irene
authors.initials: I
authors.lastname: Lichtscheidl
authors.forename: Bernhard K
authors.initials: BK
authors.lastname: Keppler
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005453:Fluorescence; D006801:Humans; D008856:Microscopy, Fluorescence; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry*; D013882:Thiosemicarbazones / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D011725:Pyridines; D013882:Thiosemicarbazones; C078157:3-aminopyridine-2-carboxaldehyde thiosemicarbazone; D015032:Zinc