FANCD2 hurdles the DNA interstrand crosslink.
Left unrepaired, DNA interstrand crosslinks represent impassable hurdles for DNA replication, and their removal is a complicated stepwise process involving a variety of enzymes. In a recent paper in Science, Knipscheer et al. (2009) demonstrate that the Fanconi Anemia protein FANCD2 promotes multiple steps of the crosslink repair process.
Moldovan
George-Lucian
GL
Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
D'Andrea
Alan D
AD
D000818:Animals; D004260:DNA Repair; D052236:Fanconi Anemia Complementation Group D2 Protein / Q000378:metabolism*; D006801:Humans
D052236:Fanconi Anemia Complementation Group D2 Protein