Expression of master regulators of helper T-cell differentiation in peripheral T-cell lymphoma, not otherwise specified, by immunohistochemical analysis.
The normal counterparts of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) have not been accurately identified. We immunohistochemically analyzed 10 PTCL-NOS cases to examine the expression of the master regulators of T-cell differentiation and of surface antigens, including chemokine receptors. All cases were positive for the master regulator of helper T cells (Th-POK) and the marker of effector T cells (CD45RO). Three cases each were positive for T-Bet and GATA3, which are master regulators of helper T cells (T(H) ) type 1 (T(H)1) and 2 (T(H)2), respectively. Two cases were positive for the surface antigens of central memory (Tcm) (CCR7 and CD62L), and 1 case was positive for follicular helper T-cell (TFH) phenotype (BCL6, CXCL13, and PD-1). The remaining case was negative for all markers of effector T(H) subtypes. These results suggest the postulated normal counterparts of PTCL-NOS identified in 9 of the 10 cases consist of T(H)1, T(H)2, TCM, and TFH.
Matsumoto
Yosuke
Y
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan.
Horiike
Shigeo
S
Ohshiro
Muneo
M
Yamamoto
Mio
M
Sasaki
Nana
N
Tsutsumi
Yasuhiko
Y
Kobayashi
Tsutomu
T
Shimizu
Daisuke
D
Uchiyama
Hitoji
H
Kuroda
Junya
J
Nomura
Kenichi
K
Shimazaki
Chihiro
C
Taniwaki
Masafumi
M
D000328:Adult; D000368:Aged; D000954:Antigens, Surface / Q000378:metabolism; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017493:Leukocyte Common Antigens / Q000378:metabolism*; D016411:Lymphoma, T-Cell, Peripheral / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D054367:Receptors, CXCR3 / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology*; D014157:Transcription Factors / Q000378:metabolism*
D000954:Antigens, Surface; C515187:CXCR3 protein, human; D004268:DNA-Binding Proteins; D054367:Receptors, CXCR3; D014157:Transcription Factors; C484225:ZBTB7B protein, human; D017493:Leukocyte Common Antigens