title: Mumps vaccine associated orchitis: Evidence supporting a potential immune-mediated mechanism.
abstract: We report 3 cases of orchitis following vaccination with mumps-measles-rubella (MMR) vaccine, two with an onset within 3 days following vaccination. Orchitis is a common complication of mumps infection, particularly in post-pubertal males, and is also recognized as a very rare complication of mumps vaccination. These cases, discussed together with a comprehensive review of the existing literature regarding post-vaccine orchitis, highlight uncertainty regarding the pathogenesis of post-vaccine orchitis.
authors.affiliation: Infectious Diseases Unit, Department of General Medicine & Murdoch Childrens Research Institute, Royal Children's Hospital Melbourne, Parkville, Victoria 3052, Australia. vanessa.clifford@rch.org.au
authors.forename: Vanessa
authors.initials: V
authors.lastname: Clifford
authors.forename: Jane
authors.initials: J
authors.lastname: Wadsley
authors.forename: Bernard
authors.initials: B
authors.lastname: Jenner
authors.forename: Jim P
authors.initials: JP
authors.lastname: Buttery
mesh_terms: D000328:Adult; D006801:Humans; D007223:Infant; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000009:adverse effects*; D009920:Orchitis / Q000139:chemically induced* / Q000453:epidemiology / Q000276:immunology*
chemical_list: D022542:Measles-Mumps-Rubella Vaccine