title: Outbreak of acquired ocular toxoplasmosis involving 248 patients.
abstract: OBJECTIVE
  To describe the demographic profile and clinical and laboratory findings of 248 patients with acquired retinitis caused by systemic infection with toxoplasmosis in a presumed outbreak of the disease.
  
  
  METHODS
  Retrospective observational case series.
  
  
  RESULTS
  Most patients (209) were residents of one city in Southern India. A total of 35 patients had a prodrome of fever, and 242 patients had unilateral retinitis without associated old retinochoroidal scars. All had laboratory evidence of acquired systemic infection with Toxoplasma gondii, and all favorably responded to antitoxoplasma therapy. Toxoplasma IgM and IgG antibodies were detected, suggesting recently acquired systemic disease. Complications seen were macular scars in 50 eyes (25.1%); epiretinal membranes, 23 eyes (11.5%); cataract, 5 eyes (2.5%); posterior vitreous detachment, 12 eyes (6%); and retinal detachment, 12 eyes (6%). One recurrence has been seen. The suspected source of infection is municipal drinking water.
  
  
  CONCLUSIONS
  Large numbers of residents of any age in a population are at risk of acquiring ocular disease during an outbreak of toxoplasmosis, which can go unnoticed, and can cause significant ocular morbidity.
authors.affiliation: Uvea Clinic, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, 641014, India. dr.mb@cbe.aravind.org
authors.forename: Manohar B
authors.initials: MB
authors.lastname: Balasundaram
authors.forename: Raghuram
authors.initials: R
authors.lastname: Andavar
authors.forename: Manikandan
authors.initials: M
authors.lastname: Palaniswamy
authors.forename: Narendran
authors.initials: N
authors.lastname: Venkatapathy
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000913:Antibodies, Protozoan / Q000097:blood; D002648:Child; D004196:Disease Outbreaks; D004359:Drug Therapy, Combination; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012173:Retinitis / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology; D012189:Retrospective Studies; D017678:Sex Distribution; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014122:Toxoplasma / Q000276:immunology; D014126:Toxoplasmosis, Ocular / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology; D014295:Trimethoprim / Q000627:therapeutic use
chemical_list: D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D014295:Trimethoprim; D013420:Sulfamethoxazole