title: [Safety and immunogenicity of measles attenuated live vaccine prepared by master seed lot vaccine of Shanghai-191 strain].
abstract: OBJECTIVE
  To evaluate the safety and immunogenicity of a new measles vaccine prepared by master seed lot original vaccine of Shanghai-191 strain.
  
  
  METHODS
  According to selection and exclusion criteria, 8-10-month healthy children, who have no history of measles, measles vaccine inoculation and vaccination contraindication were selected. The children selected were vaccinated 0.5 ml measles attenuate live vaccine prepared by master seed lot vaccine of the Shanghai-191 strain. They were observed the local and systemic response in 30 min and 6h, 24h, 48h, 72h, 7d, 14d, 21d, 28d after inoculation, and immune serum were collected before immunization and after 28 days. Measles virus antibody positive rate and geometric mean titer (GMT) were detected by hemagglutination inhibition.
  
  
  RESULTS
  There were not serious adverse reactions. Measles virus antibodies in serum positive rate was 100% after 28 days of immunization, and measles virus antibody GMT was 1:50.66.
  
  
  CONCLUSIONS
  New measles vaccine prepared by master seed lot original vaccine of the Shanghai-191 strain at 8-10-month children was safe and immunogenicity.
authors.affiliation: Human provincial Center for Disease Control and Prevention, Changsha 410005, Hunan, China.
authors.forename: Shu-Jun
authors.initials: SJ
authors.lastname: Zhang
authors.forename: Qi-You
authors.initials: QY
authors.lastname: Xiao
authors.forename: Fang-Jun
authors.initials: FJ
authors.lastname: Li
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D002681:China; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008457:Measles / Q000097:blood / Q000276:immunology* / Q000821:virology; D008458:Measles Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D008458:Measles Vaccine; D014613:Vaccines, Attenuated