Expression of placenta growth factor: an independent factor for prediction of progression and prognosis of oral cancer.
BACKGROUND
Expression of placenta growth factor (PlGF) is found to correlate with the progression and prognosis of several human cancers.


METHODS
This study used an immunohistochemical technique to examine the expression of PlGF in 100 specimens of oral squamous cell carcinoma (OSCC).


RESULTS
We found that the higher mean PlGF labeling index was significantly associated with OSCCs with positive lymph node metastasis (p = .014) or with more advanced clinical stages (p = .016). Positive lymph node metastasis (p = .008) and PlGF labeling index >40% (p = .010) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. Moreover, a Kaplan-Meier curve showed that OSCC patients with a PlGF labeling index >40% had a significantly poorer cumulative survival than those with a PlGF labeling index ≤40% (log-rank test, p = .003).


CONCLUSIONS
The PlGF labeling index can predict the progression and prognosis of OSCCs in Taiwan.
Cheng
Shih-Jung
SJ
Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
Lee
Jang-Jaer
JJ
Kok
Sang-Heng
SH
Chou
Chia-Hsuan
CH
Chang
Hao-Hueng
HH
Chiang
Meng Ling
ML
Chen
Hsin-Ming
HM
Kuo
Mark Yen-Ping
MY
Chiang
Chun-Pin
CP
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D015999:Multivariate Analysis; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000378:metabolism*; D011379:Prognosis
C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor