Production of c9,t11- and t10,c12-conjugated linoleic acids in humans by Lactobacillus rhamnosus PL60.
Lactobacillus rhamnosus PL60 was tested for whether it can produce c9,t11- and t10,c12-conjugated linoleic acids (CLAs) in human. After consumption of L. rhamnosus PL60, L. rhamnosus was detected in feces 1 week after the start of intake. Analysis by gas chromatography showed that concentrations of c9,t11- and t10,c12-CLAs in serum had increased and concentrations of serum leptin had significantly decreased. Results showed that L. rhamnosus PL60 can survive in human intestines and produce CLAs in human. This is the first report that bacteria can produce CLAs in humans.
Lee
Kieun
K
Culture Collection of Antimicrobial Resistant Microbes, Department of Biology, Seoul Women's University, Seoul 139-744, Korea.
Lee
Yeonhee
Y
D000328:Adult; D002849:Chromatography, Gas; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D004334:Drug Administration Schedule; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology; D052201:Lacticaseibacillus rhamnosus / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D020738:Leptin / Q000097:blood; D044243:Linoleic Acids, Conjugated / Q000096:biosynthesis* / Q000097:blood / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism / Q000517:prevention & control; D019936:Probiotics / Q000008:administration & dosage; D013997:Time Factors
D004269:DNA, Bacterial; D020738:Leptin; D044243:Linoleic Acids, Conjugated