title: Reduced retinal blood flow velocity in diabetic retinopathy.
abstract: OBJECTIVE
  The purpose of this study was to compare the retinal blood flow velocities of patients with diabetes and healthy control subjects. We used a novel device offering a noninvasive diagnostic of retinal function.
  
  
  METHODS
  Flow velocities in retinal arterioles and venules were quantitatively analyzed by retinal function imager scanning in 58 eyes of 42 patients with nonproliferative diabetic retinopathy and 51 eyes of 32 normal subjects. Group differences were assessed by the mixed-model effect.
  
  
  RESULTS
  Average velocity in arterial compartments (in mm/s) was 3.74 +/- 1.09 for the diabetic group and 4.19 +/- 0.99 for the control subjects. The average velocity of all segments, taking associated heart rate and individual segment widths into account, was 17% slower in the diabetic group (P < 0.0001). In both groups, average venous compartment velocity was lower than the arterial velocity (2.61 +/- 0.65 for the diabetic group; 3.03 +/- 0.59 for the control subjects). Individual vein velocities, taking heart rate and segment widths into account, was 17% slower, on average, in the diabetic group (P < 0.0001).
  
  
  CONCLUSIONS
  Our measurement showed significantly decreased flow velocities in the retinal arterioles and venules of patients with diabetes compared with healthy control subjects, supporting the view of abnormal vessel function in eyes with nonproliferative diabetic retinopathy.
authors.affiliation: Department of Ophthalmology, Edith Wolfson Medical Center, Holon, Israel. zviaeb@gmail.com
authors.forename: Zvia
authors.initials: Z
authors.lastname: Burgansky-Eliash
authors.forename: Darin A
authors.initials: DA
authors.lastname: Nelson
authors.forename: Orly Pupko
authors.initials: OP
authors.lastname: Bar-Tal
authors.forename: Anat
authors.initials: A
authors.lastname: Lowenstein
authors.forename: Amiram
authors.initials: A
authors.lastname: Grinvald
authors.forename: Adiel
authors.initials: A
authors.lastname: Barak
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000502:physiology; D003430:Cross-Sectional Studies; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012039:Regional Blood Flow / Q000502:physiology; D012161:Retinal Artery / Q000502:physiology*; D012169:Retinal Vein / Q000502:physiology*; D014792:Visual Acuity / Q000502:physiology