title: Helicobacter pylori antibiotic resistance and [13C]urea breath test values.
abstract: A correlation between delta over baseline (DOB) values of the [(13)C]urea breath test (UBT) and Helicobacter pylori clarithromycin resistance has been reported, suggesting a possible predictive role of UBT in therapeutic outcome. However, available data are limited and conflicting. This study aimed to clarify this issue, assessing the possible relationship between H. pylori resistance towards different antibiotics (clarithromycin, metronidazole and levofloxacin) and UBT values. The data showed similar DOB values between susceptible and resistant strains for clarithromycin (46.9+/-32.3 vs 45.7+/-30.6; P=0.8), metronidazole (46.4+/-29.6 vs 47.4+/-37.9; P=0.8), and levofloxacin (45.0+/-30.2 vs 54.2+/-38.4; P=0.08). Likewise, comparable DOB values were observed between susceptible and multidrug-resistant strains (45.4+/-29.6 vs 54.8+/-44.8; P=0.1). In conclusion, our data failed to find a significant correlation between UBT values and H. pylori antibiotic resistance.
authors.affiliation: Section of Gastroenterology, Department of Medical Sciences, University of Foggia, Foggia, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Francesco
authors.affiliation: Gastroenterology and Digestive Endoscopy, 'Nuovo Regina Margherita' Hospital, Rome, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Zullo
authors.affiliation: Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Perna
authors.affiliation: Section of Gastroenterology, Department of Medical Sciences, University of Foggia, Foggia, Italy.
authors.forename: Floriana
authors.initials: F
authors.lastname: Giorgio
authors.affiliation: Gastroenterology and Digestive Endoscopy, 'Nuovo Regina Margherita' Hospital, Rome, Italy.
authors.forename: Cesare
authors.initials: C
authors.lastname: Hassan
authors.affiliation: Section of Gastroenterology, Department of Medical Sciences, University of Foggia, Foggia, Italy.
authors.forename: Lucy
authors.initials: L
authors.lastname: Vannella
authors.affiliation: Gastroenterology and Digestive Endoscopy, 'Nuovo Regina Margherita' Hospital, Rome, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Cristofari
authors.affiliation: Section of Gastroenterology, Department of Medical Sciences, University of Foggia, Foggia, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Panella
authors.affiliation: Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy.
authors.forename: Dino
authors.initials: D
authors.lastname: Vaira
authors.affiliation: Section of Gastroenterology, Department of Medical Sciences, University of Foggia, Foggia, Italy.
authors.forename: Enzo
authors.initials: E
authors.lastname: Ierardi
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000032:analysis*; D001944:Breath Tests; D017291:Clarithromycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005260:Female; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification*; D006801:Humans; D064704:Levofloxacin; D008297:Male; D008795:Metronidazole / Q000494:pharmacology; D008875:Middle Aged; D015242:Ofloxacin / Q000494:pharmacology; D013223:Statistics as Topic; D014508:Urea / Q000378:metabolism; D014510:Urease / Q000032:analysis
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D008795:Metronidazole; D064704:Levofloxacin; D014508:Urea; D015242:Ofloxacin; D014510:Urease; D017291:Clarithromycin