Human embryonic stem cell-derived keratinocytes: how close to clinics?
Recently in The Lancet, Guenou et al. (2009) demonstrate that human embryonic stem cells (hESCs) can differentiate into mature keratinocytes able to generate a pluristratified epithelium on immunodeficient mice. Their findings and the potential clinical use of hESC-derived keratinocytes will be discussed.
Pellegrini
Graziella
G
Centre for Regenerative Medicine "Stefano Ferrari," University of Modena and Reggio Emilia, 41100 Modena, Italy.
De Luca
Michele
M
D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D015603:Keratinocytes / Q000166:cytology* / Q000378:metabolism