Improving regenerating potential of the heart after myocardial infarction: factor-based approach.
The emerging evidence that the heart has the potential to regenerate, albeit not ideally, has stimulated considerable interest in the field of cardiac regenerative medicine. Several lines of research demonstrated that factor-based therapy is feasible and effective, whether it is used independently or as an adjunct to cell therapy. The ultimate goal of the factor-based approach is to improve the regenerating potential of the heart as a means to treat patients with cardiovascular disease. This article reviews recent approaches involving factor-based therapy for cardiac repair and regeneration including some of the advantages of this type of therapy as well as some of the hurdles that must be overcome before this therapeutic approach becomes a standard part of clinical medicine.
Hwang
Hyosook
H
Heart Institute, Good Samaritan Hospital, Los Angeles, CA 90017, United States.
Kloner
Robert A
RA
D000375:Aging; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000628:therapy; D016207:Cytokines / Q000627:therapeutic use; D006321:Heart / Q000502:physiology*; D016298:Hematopoietic Cell Growth Factors / Q000627:therapeutic use*; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy / Q000473:pathology* / Q000628:therapy*; D012038:Regeneration / Q000502:physiology*; D044968:Regenerative Medicine; D042442:Vascular Endothelial Growth Factors / Q000627:therapeutic use*
D016207:Cytokines; D016298:Hematopoietic Cell Growth Factors; D042442:Vascular Endothelial Growth Factors