title: Senile systemic amyloidosis in an aged savannah monkey (Cercopithecus aethiops) with tenosynovial degeneration.
abstract: Senile systemic amyloidosis (SSA) is a rather common disease in elderly people, but it is very rare in animals, including nonhuman primates. Pathological examination of a 26-year-old male savannah monkey (Cercopithecus aethiops) revealed systemic amyloidosis with severe cardiac fibrosis, and tenosynovial degeneration of the elbow and knee joints. The amyloid deposits were observed predominantly in the heart, lung, intestine and tenosynovium, and were positive for transthyretin (TTR) in immunohistochemistry. Immunohistochemical results, together with the distribution of the amyloid deposited lesions and the age of the monkey, were equivalent to those of human SSA. This is the second case of animal SSA with unprecedented TTR amyloid deposited lesions of the tenosynovium resembling human SSA. There may be a genetic factor that makes this species susceptible to SSA, since SSA has been reported in no other mammal besides humans.
authors.affiliation: Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, Fuchinobe, Sagamihara, Kanagawa, Japan.
authors.forename: James Kenn
authors.initials: JK
authors.lastname: Chambers
authors.forename: Takuya
authors.initials: T
authors.lastname: Kanda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shirai
authors.forename: Keiichi
authors.initials: K
authors.lastname: Higuchi
authors.forename: Shu-Ichi
authors.initials: S
authors.lastname: Ikeda
authors.forename: Yumi
authors.initials: Y
authors.lastname: Une
mesh_terms: D000686:Amyloidosis / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D000836:Animals, Zoo; D002522:Chlorocebus aethiops; D017809:Fatal Outcome; D005355:Fibrosis / Q000473:pathology / Q000662:veterinary; D006325:Heart Atria / Q000473:pathology; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D007564:Japan; D008297:Male; D008992:Monkey Diseases / Q000473:pathology*; D009206:Myocardium / Q000473:pathology; D013045:Species Specificity