title: Immunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinoma.
abstract: OBJECTIVE
  To correlate the expression of p53 protein and VEGF with the prognosis of patients submitted to curative resection to treat esophageal adenocarcinoma.
  
  
  METHODS
  Forty-six patients with esophageal adenocarcinoma, submitted to curative resection, were studied. The expressions of p53 protein and VEGF were assessed by immunohistochemistry in 52.2% and 47.8% of tumors, respectively.
  
  
  RESULTS
  P53 protein and VEGF expressions coincided in 26% of the cases, and no correlation between these expressions was observed. None of the clinicopathological factors showed a significant correlation with p53 protein or VEGF expressions. There was no significant association between p53 protein and VEGF expressions and long-term survival.
  
  
  CONCLUSIONS
  The expression of p53 protein and VEGF did not correlate with prognosis in esophageal adenocarcinoma patients submitted to curative resection.
authors.affiliation: Departamento de Patologia, UFRGS, RS, BR. cavazzola@gmail.com
authors.forename: Leandro Totti
authors.initials: LT
authors.lastname: Cavazzola
authors.forename: André Ricardo Pereira da
authors.initials: AR
authors.lastname: Rosa
authors.forename: Carlos Cauduro
authors.initials: CC
authors.lastname: Schirmer
authors.forename: Richard Ricachenevski
authors.initials: RR
authors.lastname: Gurski
authors.forename: João Pedro Bueno
authors.initials: JP
authors.lastname: Telles
authors.forename: Fernando
authors.initials: F
authors.lastname: Mielke
authors.forename: Luíse
authors.initials: L
authors.lastname: Meurer
authors.forename: Maria Isabel Albano
authors.initials: MI
authors.lastname: Edelweiss
authors.forename: Cleber Dario Pinto
authors.initials: CD
authors.lastname: Kruel
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000378:metabolism* / Q000401:mortality*; D000328:Adult; D000368:Aged; D004938:Esophageal Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000401:mortality*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D015996:Survival Rate; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000096:biosynthesis*; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis* / Q000096:biosynthesis*
chemical_list: D016159:Tumor Suppressor Protein p53; D042461:Vascular Endothelial Growth Factor A