title: Forepaw sensorimotor deprivation in early life leads to the impairments on spatial memory and synaptic plasticity in rats.
abstract: To investigate the influence of forepaw sensorimotor deprivation on memory and synaptic plasticity, Sprague-Dawley rats were divided into two groups: a sham-operated group and a group deprived of forepaw sensorimotor function by microsurgical operation at postnatal day 13 (PN13). Behavioral and electrophysiological studies were performed at PN25, PN35, PN45, and PN60. Open field test was used to assess the spontaneous locomotor activity. Morris water maze was used to evaluate spatial reference learning and memory. The long-term potentiation (LTP) in the medial perforant path--dentate gyrus (MPP-DG) pathway was examined with hippocampal slices. We found that forepaw sensorimotor deprivation did not affect spontaneous activity of the rats. However, spatial reference learning and memory were significantly impaired in their early life (PN25, PN35, and PN45). In accordance with the behavior results, LTP in MPP-DG pathway was significantly suppressed in their early life. These data demonstrated that forepaw sensorimotor deprivation led to the impairments on spatial memory via inducing pronounced deficits in the MPP-DG pathway to exhibit LTP, one of the major cellular mechanisms underlying learning and memory.
authors.affiliation: Shanghai Key Laboratory of Children's Environmental Health, Shanghai Institute for Pediatric Research, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Cao
authors.forename: Xingming
authors.initials: X
authors.lastname: Jin
authors.forename: Chonghuai
authors.initials: C
authors.lastname: Yan
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Shen
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D018891:Dentate Gyrus / Q000503:physiopathology; D005552:Forelimb / Q000503:physiopathology*; D066298:In Vitro Techniques; D008124:Locomotion / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology; D018782:Maze Learning; D008568:Memory / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D019580:Perforant Pathway / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley