Antiobesity and hypolipidemic effects of polyphenol-rich longan (Dimocarpus longans Lour.) flower water extract in hypercaloric-dietary rats.
Plenty of polyphenols, i.e. phenolic acids and flavonoids, were found in longan flower water extract (LFWE) through spectrophotometric and HPLC analyses. Antiobesity and hypolipidemic effects of polyphenol-rich longan flower water extract (LFWE) were investigated in this study. Eight male rats per group were assigned randomly to one of the following dietary groups: (1) normal-caloric diet and pure water (NCD + NDW); (2) hypercaloric diet and pure water (HCD + NDW); (3) HCD and 1.25% (w/v) LFWE (HCD + 1.25% LFWE); (4) HCD and 2.5% (w/v) LFWE (HCD + 2.5% LFWE) for 9 weeks. Body weight, size of epididymal fat, serum triglyceride level and atherogenic index, and hepatic lipids were decreased (p < 0.05) in HCD rats by drinking 2.5% LFWE which may result from downregulated (p < 0.05) pancreatic lipase activity, and sterol regulatory element binding protein-1c (SREBP-1c) and fatty acid synthase (FAS) gene expressions, as well as upregulated (p < 0.05) LDL receptor (LDLR) and peroxisome proliferator-activated-receptor-alpha (PPAR-alpha) gene expressions, and also increased (p < 0.05) fecal triglyceride excretions. Therefore, polyphenol-rich LFWE indeed characterizes antiobesity and hypolipidemic effects in vivo.
Yang
Deng-Jye
DJ
School of Health Diet and Industry Management, Chung Shan Medical University, Taichung 402, Taiwan.
Chang
Yuan-Yen
YY
Hsu
Chin-Lin
CL
Liu
Cheng-Wei
CW
Lin
Yi-Ling
YL
Lin
Yu-Huei
YH
Liu
Kai-Cheng
KC
Chen
Yi-Chen
YC
D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005419:Flavonoids / Q000627:therapeutic use*; D035264:Flowers / Q000737:chemistry; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D000960:Hypolipidemic Agents / Q000008:administration & dosage*; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D009765:Obesity / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D047493:PPAR alpha / Q000235:genetics / Q000378:metabolism; D010636:Phenols / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*; D059808:Polyphenols; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D029631:Sapindaceae / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood
D004041:Dietary Fats; D005419:Flavonoids; D000960:Hypolipidemic Agents; D047493:PPAR alpha; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D014280:Triglycerides