[Evaluation of promoting effect of several transdermal enhancers with fuzzy matter-element model].
OBJECTIVE
To investigate the utilization of fuzzy matter - element model in evaluating the promoting effects of transdermal enhancers.


METHODS
Paracetamol was used as drug model. Azone, menthol, camphor, oleic acid, clove oil, Schizonepeta tenuifolia oil and patchouli were used as transdermal enhancers. Transdermal absorption experimentation of paracetamol was detected on the device of penetrating skins of rabbit in vitro and penetrating rates, steady fluxs, lag time and enhancement ratio were calculated to evaluate promoting effects of transdermal enhancers with fuzzy matter-element model based on variation coefficient weight.


RESULTS
Paracetamol had the best promoting function with 2% clove oil and 2% camphor. The function drops slightly with 1% azone, 2% Schizonepeta tenuifolia oil, 2% menthol and 2% oleic acid ranked behind. The worst was with 2% patchouli.


CONCLUSIONS
Fuzzy matter-element model based on variation coefficient weight could judge the promoting and penetrating effect of transdermal enhancers objectively and feasible.
Zheng
Xiaoyan
X
Department of Pharmacology of Traditonal Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
Wang
Hui
H
Cheng
Kuoju
K
Liang
Qing
Q
D000082:Acetaminophen / Q000493:pharmacokinetics; D000277:Adjuvants, Pharmaceutic / Q000737:chemistry*; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D008954:Models, Biological; D011817:Rabbits; D012869:Skin Absorption
D000277:Adjuvants, Pharmaceutic; D000082:Acetaminophen