Neuroglobin expression in ischemic stroke.
OBJECTIVE
We investigated whether neuroglobin, a neuronal protein that protects neurons from hypoxic-ischemic injury, is upregulated in ischemic stroke.


METHODS
Neuroglobin immunoreactivity was measured in brain tissue from control subjects and patients with ischemic stroke.


RESULTS
Neuroglobin was detected in several brain areas, and its expression was increased in the cortical peri-infarct region after stroke.


CONCLUSIONS
Ischemic stroke increases expression of the neuroprotective protein neuroglobin, suggesting neuroglobin may represent a novel target for stroke therapy.
Jin
Kunlin
K
Mao
Ying
Y
Mao
Xiao
X
Xie
Lin
L
Greenberg
David A
DA
D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000378:metabolism* / Q000517:prevention & control; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D005914:Globins / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D000078787:Neuroglobin; D020521:Stroke / Q000378:metabolism* / Q000517:prevention & control; D015854:Up-Regulation / Q000502:physiology
D009419:Nerve Tissue Proteins; D000078787:Neuroglobin; D005914:Globins