title: Sleep-disordered breathing changes after kidney transplantation: a polysomnographic study.
abstract: BACKGROUND
  Sleep disorders are common in patients with end-stage renal disease (ESRD) and are not improved by either conventional haemodialysis or peritoneal dialysis. Sleep-disordered breathing (SDB) is associated with cardiovascular disease and contributes to high mortality found in patients with ESRD. Cure of SDB after transplantation has been anecdotally reported.
  
  
  METHODS
  Thirty-four non-diabetic patients with ESRD were studied, and clinical, laboratory test and polysomnographic features were determined and compared prior to and after transplantation and between groups with or without SDB, defined as having an apnoea-hypopnoea index (AHI) >or=5.
  
  
  RESULTS
  An AHI >or=5 was present in nine patients (26.5%) prior to and seven (21%) after transplantation, and no significant reduction of mean AHI was found between study phases (5.3 +/- 7.3 vs 3.1 +/- 4.5; P > 0.05). Transplantation was associated with a significant improvement in sleep architecture.
  
  
  CONCLUSIONS
  Kidney transplantation is associated with an improvement in sleep architecture, but does not cure SDB in all patients.
authors.affiliation: Nephrology Division, Federal University of São Paulo, Brazil. cjorodrigues@uol.com.br
authors.forename: Cassio J O
authors.initials: CJ
authors.lastname: Rodrigues
authors.forename: Odair
authors.initials: O
authors.lastname: Marson
authors.forename: Sonia M G P
authors.initials: SM
authors.lastname: Togeiro
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
authors.forename: Artur B
authors.initials: AB
authors.lastname: Ribeiro
authors.forename: Agostinho
authors.initials: A
authors.lastname: Tavares
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D006435:Renal Dialysis; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy