Increased ratio of 2nd to 4th digit (2D:4D) in schizophrenia.
Sex differences in the onset, epidemiology, clinical presentation and neuropathology of schizophrenia suggest that sexual dimorphism in brain development may be relevant to pathogenesis. Sex hormones, in particular testosterone, are considered to be crucial in brain development, but few investigations have examined the potential role of prenatal testosterone in schizophrenia. In this study, we examined a retrospective marker of prenatal testosterone release - 2D:4D finger length ratio (2D:4D), the relative length of 2nd to 4th digit, in 64 Asian patients with schizophrenia and 64 sex-matched controls. No significant difference in mean finger lengths was present, however 2D:4D ratio was significantly different between patients and controls. The effect was primarily seen in males consistent with a 'less masculinised' pattern and hypotheses suggesting that schizophrenia may be associated with an abnormality in prenatal circulating testosterone.
Collinson
Simon Lowes
SL
Department of Psychology, National University of Singapore, 117570, Singapore. psycsl@nus.edu.sg
Lim
Matthew
M
Chaw
Jia Hui
JH
Verma
Swapna
S
Sim
Kang
K
Rapisarda
Attilio
A
Chong
Siow Ann
SA
D000328:Adult; D044466:Asian People; D049628:Body Size / Q000502:physiology*; D016022:Case-Control Studies; D005260:Female; D005385:Fingers / Q000033:anatomy & histology*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012559:Schizophrenia / Q000473:pathology*; D012737:Sex Factors; D013739:Testosterone / Q000502:physiology; D055815:Young Adult
D013739:Testosterone