title: Implications of body mass index in Japanese patients with prostate cancer who had undergone radical prostatectomy.
abstract: OBJECTIVE
  To determine the association between obesity and prostate cancer in Japanese recurrence after primary treatment with radical prostatectomy.
  
  
  METHODS
  The subjects were 173 Japanese patients with prostate cancer who had been treated with radical prostatectomy at Chiba University Hospital between April 1997 and March 2007. Clinicopathological characteristics and biochemical recurrence outcomes after radical prostatectomy were compared between the three body mass index cohorts.
  
  
  RESULTS
  Mean body mass index was 23.4 kg/m(2) with a standard deviation of 2.4, and mean follow-up period was 37.4 months. Operative time was longer and estimated blood loss was much more in obese patients. Patients with pT3>or= had significantly higher serum prostate-specific antigen, total cholesterol levels, Gleason's sum and positive of surgical margin than pT2 patients. Recurrence rate was significantly higher in the 26.5 kg/m(2) and hyperlipidemia groups in pT3>or= patients.
  
  
  CONCLUSIONS
  Obesity is an independent predictor of disease recurrence in Japanese patients with pT3>or= prostate cancer who underwent radical prostatectomy. Obese patients who underwent radical prostatectomy require vigilant follow-up care.
authors.affiliation: Department of Urology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Komaru
authors.forename: Naoto
authors.initials: N
authors.lastname: Kamiya
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Takumi
authors.initials: T
authors.lastname: Endo
authors.forename: Makoto
authors.initials: M
authors.lastname: Takano
authors.forename: Masashi
authors.initials: M
authors.lastname: Yano
authors.forename: Koji
authors.initials: K
authors.lastname: Kawamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Imamoto
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Ichikawa
mesh_terms: D044466:Asian People; D015992:Body Mass Index; D018572:Disease-Free Survival; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D053208:Kaplan-Meier Estimate; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000453:epidemiology / Q000473:pathology; D009367:Neoplasm Staging; D009765:Obesity / Q000150:complications*; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000150:complications* / Q000473:pathology* / Q000601:surgery*; D012307:Risk Factors
chemical_list: D017430:Prostate-Specific Antigen