title: Premature ejaculation: treatment update.
abstract: Premature ejaculation (PE) is the most common male sexual problem worldwide affecting 22-38% of men. It has a significant morbidity both on patients and their partners, causing distress, anxiety and relationship difficulties. The mainstay of treatment is a combined approach using behavioural therapies and non-licensed medication such as topical anaesthetic preparations, selective serotonin re-uptake inhibitors and phosphodiesterase-5 inhibitors. In recent years, there has been a greater emphasis placed on researching novel treatments and exploring the on-demand use of current preparations. This review provides an overview of current accepted treatments and emerging agents for the use in PE.
authors.affiliation: Department of Genitourinary Medicine, Royal Victoria Hospital, Grosvenor Road, Belfast BT126BA, UK. ej_mccarty@hotmail.com
authors.forename: E J
authors.initials: EJ
authors.lastname: McCarty
authors.forename: W W
authors.initials: WW
authors.lastname: Dinsmore
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D019162:Anesthetics, Combined / Q000627:therapeutic use; D000779:Anesthetics, Local / Q000008:administration & dosage; D001596:Benzylamines / Q000008:administration & dosage / Q000627:therapeutic use; D004542:Ejaculation; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use; D000077442:Lidocaine, Prilocaine Drug Combination; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use; D058986:Phosphodiesterase 5 Inhibitors; D011318:Prilocaine / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy*
chemical_list: D019162:Anesthetics, Combined; D000779:Anesthetics, Local; D001596:Benzylamines; D004791:Enzyme Inhibitors; D008012:Lidocaine; D000077442:Lidocaine, Prilocaine Drug Combination; D009281:Naphthalenes; D058986:Phosphodiesterase 5 Inhibitors; D011318:Prilocaine; D017367:Selective Serotonin Reuptake Inhibitors; C080598:dapoxetine