title: Increasing hospital admission rates for urological complications after transrectal ultrasound guided prostate biopsy.
abstract: OBJECTIVE
  Transrectal ultrasound guided prostate biopsy is widely used to confirm the diagnosis of prostate cancer. The technique has been associated with significant morbidity in a small proportion of patients.
  
  
  METHODS
  We conducted a population based study of 75,190 men who underwent a transrectal ultrasound guided biopsy in Ontario, Canada, between 1996 and 2005. We used hospital and cancer registry administrative databases to estimate the rates of hospital admission and mortality due to urological complications associated with the procedure.
  
  
  RESULTS
  Of the 75,190 men who underwent transrectal ultrasound biopsy 33,508 (44.6%) were diagnosed with prostate cancer and 41,682 (55.4%) did not have prostate cancer. The hospital admission rate for urological complications within 30 days of the procedure for men without cancer was 1.9% (781/41,482). The 30-day hospital admission rate increased from 1.0% in 1996 to 4.1% in 2005 (p for trend <0.0001). The majority of hospital admissions (72%) were for infection related reasons. The probability of being admitted to hospital within 30 days of having the procedure increased 4-fold between 1996 and 2005 (OR 3.7, 95% CI 2.0-7.0, p <0.0001). The overall 30-day mortality rate was 0.09% but did not change during the study period.
  
  
  CONCLUSIONS
  The hospital admission rates for complications following transrectal ultrasound guided prostate biopsy have increased dramatically during the last 10 years primarily due to an increasing rate of infection related complications.
authors.affiliation: Division of Urology, Sunnybrook Research Institute, Toronto, Ontario, Canada. Robert.nam@utoronto.ca
authors.forename: Robert K
authors.initials: RK
authors.lastname: Nam
authors.forename: Refik
authors.initials: R
authors.lastname: Saskin
authors.forename: Yuna
authors.initials: Y
authors.lastname: Lee
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Calvin
authors.initials: C
authors.lastname: Law
authors.forename: Laurence H
authors.initials: LH
authors.lastname: Klotz
authors.forename: D Andrew
authors.initials: DA
authors.lastname: Loblaw
authors.forename: John
authors.initials: J
authors.lastname: Trachtenberg
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Stanimirovic
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Simor
authors.forename: Arun
authors.initials: A
authors.lastname: Seth
authors.forename: David R
authors.initials: DR
authors.lastname: Urbach
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000009:adverse effects / Q000379:methods; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010343:Patient Admission / Q000706:statistics & numerical data*; D011467:Prostate / Q000473:pathology*; D012007:Rectum; D012189:Retrospective Studies; D014570:Urologic Diseases / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy