title: [Ultrasound-guided intervention in the treatment of abdomino-pelvic advanced tumors].
abstract: OBJECTIVE
  The goal of this study was to evaluate the accuracy and safety of ultrasound-guided tru-cut biopsy in advanced abdomino-pelvic tumors in a sufficiently large cohort.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Oncogynecological Center, Department of Obstetrics and Gynecology, General Faculty Hospital of Charles University, Prague.
  
  
  METHODS
  Patients indicated for tru-cut biopsy were those with primarily inoperable tumors, with advanced tumors and compromised performance status preventing a primary surgical procedure, and with recurrent pelvic tumors requiring histological verification. All were referred to the Oncogynecological Center between January 2005 and June 2007. Tru-cut biopsy was taken either from pelvic tumor or from its metastatic sites transvaginally or transabdominally under ultrasound guidance. Sample adequacy was evaluated.
  
  
  RESULTS
  Altogether, 119 patients were referred for tru-cut biopsy during a study period. Only 4 cases were found unsuitable for tru-cut biopsy and the patients were referred for laparoscopy instead. Samples were obtained transvaginally in 67 patients (58.3%) and transabdominally in 48 patients (41.7%). The biopsy was taken from pelvic tumor in 59 patients (51.3%), omental cake in 14 patients (12.2%), from peritoneal visceral or parietal carcinomatosis in 37 patients (32.2%) and from other localities in 5 patients (4.3 %). The diagnostic adequacy of ultrasound-guided tru-cut biopsy reached 94.8% (95% CI, 94.17-99.40%). There were only two tru-cut biopsy-related complications: The first case involved bleeding from tumor in a patient with mild thrombocytopenia that required laparotomy; in the second case, diagnostic laparoscopy was indicated after a minor bleeding occurred in the biopsy site on ultrasound, however, no significant pelvic bleeding was confirmed by the procedure.
  
  
  CONCLUSIONS
  Ultrasound-guided tru-cut biopsy is a safe, reliable, fast, and cost-effective diagnostic method for histological verification of both advanced primary and recurrent abdomino-pelvic tumors. It can be performed in an outpatient setting without the need for general anesthesia, causing a minimal discomfort to the patient in comparison with laparoscopy or laparotomy. The risk of complications is low and the main advantage is the acquirement of a sample adequate for further immunohistochemical examination, which is a necessary requirement for the choice of optimal oncological treatment.
authors.affiliation: Onkogynekologické centrum, Gynekologicko-porodnická klinika VFN a 1. LF UK, Praha. daniela.fischerova@seznam.cz
authors.forename: D
authors.initials: D
authors.lastname: Fischerová
authors.forename: D
authors.initials: D
authors.lastname: Cibula
authors.forename: M
authors.initials: M
authors.lastname: Zikán
authors.forename: P
authors.initials: P
authors.lastname: Freitag
authors.forename: J
authors.initials: J
authors.lastname: Sláma
authors.forename: N
authors.initials: N
authors.lastname: Jancárková
authors.forename: I
authors.initials: I
authors.lastname: Pinkavová
authors.forename: P
authors.initials: P
authors.lastname: Dundr
mesh_terms: D000008:Abdominal Neoplasms / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000009:adverse effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000473:pathology*; D018084:Ultrasonography, Interventional