Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk.
To identify new risk variants for chronic lymphocytic leukemia (CLL), we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four new risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio (OR) = 1.39; P = 2.11 x 10(-9)), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 x 10(-10)), 15q21.3 (rs7169431; OR = 1.36; P = 4.74 x 10(-7)) and 16q24.1 (rs305061; OR = 1.22; P = 3.60 x 10(-7)). We also found evidence for risk loci at 15q25.2 (rs783540, CPEB1; OR = 1.18; P = 3.67 x 10(-6)) and 18q21.1 (rs1036935; OR = 1.22; P = 2.28 x 10(-6)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy.
Crowther-Swanepoel
Dalemari
D
Institute of Cancer Research, Sutton, Surrey, UK.
Broderick
Peter
P
Di Bernardo
Maria Chiara
MC
Dobbins
Sara E
SE
Torres
María
M
Mansouri
Mahmoud
M
Ruiz-Ponte
Clara
C
Enjuanes
Anna
A
Rosenquist
Richard
R
Carracedo
Angel
A
Jurlander
Jesper
J
Campo
Elias
E
Juliusson
Gunnar
G
Montserrat
Emilio
E
Smedby
Karin E
KE
Dyer
Martin J S
MJ
Matutes
Estella
E
Dearden
Claire
C
Sunter
Nicola J
NJ
Hall
Andrew G
AG
Mainou-Fowler
Tryfonia
T
Jackson
Graham H
GH
Summerfield
Geoffrey
G
Harris
Robert J
RJ
Pettitt
Andrew R
AR
Allsup
David J
DJ
Bailey
James R
JR
Pratt
Guy
G
Pepper
Chris
C
Fegan
Chris
C
Parker
Anton
A
Oscier
David
D
Allan
James M
JM
Catovsky
Daniel
D
Houlston
Richard S
RS
D000483:Alleles; D002877:Chromosomes, Human / Q000235:genetics*; D056426:Genetic Loci / Q000235:genetics; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D015894:Genome, Human / Q000235:genetics; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics