Prognostic factors in desmoid-type fibromatosis: a clinicopathological and immunohistochemical analysis of 46 cases.
OBJECTIVE
To determine risk factors for recurrence of desmoid-type fibromatosis (aggressive fibromatosis).


METHODS
Forty-six cases of desmoid-type fibromatosis in Taiwanese patients were analysed for an association between tumour recurrence and clinical features, pathology, and the presence of p53 protein and beta-catenin on immunohistochemical staining.


RESULTS
Six (13%) of 46 patients developed recurrence after surgical resection. The only factor significantly associated with tumour recurrence was positive surgical margin (p = 0.035).


CONCLUSIONS
A positive surgical margin is a risk factor for recurrence of desmoid-type fibromatosis.
Huang
Pei-Wen
PW
Department of Pathology, Mackay Memorial Hospital, Taipei, Taiwan.
Tzen
Chi-Yuan
CY
D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D018221:Fibromatosis, Abdominal / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D018222:Desmoid Tumors / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012307:Risk Factors; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D051176:beta Catenin / Q000378:metabolism
D014408:Biomarkers, Tumor; C495270:CTNNB1 protein, human; D016159:Tumor Suppressor Protein p53; D051176:beta Catenin