[IgE deficiency: a forgotten disease?].
BACKGROUND
Selective IgE deficiency is a profound deficiency (< 5 UI/mL) or absence of serum IgE levels without other immunologic abnormalities. It is usually asymptomatic, but may be associated with recurrent respiratory infections, chronic fatigue, and musculoskeletal complaints.


OBJECTIVE
To describe the evolution and treatment in patients with selective IgE deficiency.


METHODS
In selective IgE's deficiency patients identification note, atopy history, concurrent diseases, clinic of allergic diseases, Prick test and prior response to treatment were analyzed.


RESULTS
Eleven patients were included, five women and six men within 16 months to 10 years old. The patients had serum IgE levels < 5 UI with other immunoglobulins and sub-classes in normal levels; except a patient with concomitant IgA and IgE deficiency. The treatment administered was since prophylactic antibiotic to intravenous gammaglobulin.


CONCLUSIONS
We established the diagnosis of selective IgE deficiency in patient with serum IgE levels < 5 UI/mL associated with recurrent respiratory infections.


CONCLUSIONS
We need more clinic studies to document with precision the selective IgE deficiency.
García Pavón Osorio
Susana
S
Servicio de Alergia e Inmunología, quinto piso, Hospital Regional Lic. Adolfo López Mateos. Universidad 1321, colonia Florida, 01030 México, DF. sus_gar_pav@yahoo.com.mx
López Tiro
José Jesús
JJ
Gómez Vera
Javier
J
D019072:Antibiotic Prophylaxis; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004198:Disease Susceptibility; D004406:Dysgammaglobulinemia / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D006801:Humans; D017098:IgA Deficiency / Q000453:epidemiology; D016867:Immunocompromised Host; D007073:Immunoglobulin E / Q000172:deficiency*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D008800:Mexico / Q000453:epidemiology; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control
D016756:Immunoglobulins, Intravenous; D007073:Immunoglobulin E