Systems cell biology of the mitotic spindle.
Cell division depends critically on the temporally controlled assembly of mitotic spindles, which are responsible for the distribution of duplicated chromosomes to each of the two daughter cells. To gain insight into the process, Vizeacoumar et al., in this issue (Vizeacoumar et al. 2010. J. Cell Biol. doi:10.1083/jcb.200909013), have combined systems genetics with high-throughput and high-content imaging to comprehensively identify and classify novel components that contribute to the morphology and function of the mitotic spindle.
Saleem
Ramsey A
RA
Institute for Systems Biology, Seattle, WA 98103, USA.
Aitchison
John D
JD
D003584:Cytological Techniques / Q000379:methods*; D005821:Genetic Techniques; D012441:Saccharomyces cerevisiae / Q000737:chemistry* / Q000166:cytology* / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000032:analysis* / Q000235:genetics / Q000378:metabolism; D008941:Spindle Apparatus / Q000737:chemistry* / Q000235:genetics; D049490:Systems Biology / Q000379:methods*
D029701:Saccharomyces cerevisiae Proteins