title: [Effects of C-reactive protein on chemotaxis ability of monocytes in vitro].
abstract: OBJECTIVE
  To investigate the effects of C-reactive protein (CRP) on monocytes chemotaxis ability in vitro.
  
  
  METHODS
  Transwell chemotaxis assay was used to evaluate the changes of chemotactic ability of THP-1 monocytes in each group treated with CRP in different concentration.
  
  
  RESULTS
  CRP increased the number of attracted monocytes in response to MCP-1 (monocyte chemoattractant protein-1). When treated with CRP concentration at 2 microg x mL(-1), the number of chemotactic monocytes increased (P < 0.05). The number of attracted monocytes increased as CRP concentration was elevated (P < 0.05).
  
  
  CONCLUSIONS
  CRP can increase chemotactic ability of THP-1 monocytes in concentration dependent manner.
authors.affiliation: State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Meng
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: He
authors.initials: H
authors.lastname: Yang
authors.forename: Ya-Fei
authors.initials: YF
authors.lastname: Wu
authors.forename: Song
authors.initials: S
authors.lastname: Ge
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
mesh_terms: D002097:C-Reactive Protein; D018932:Chemokine CCL2; D002633:Chemotaxis; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes
chemical_list: D018932:Chemokine CCL2; D002097:C-Reactive Protein