Dabigatran etexilate in venous thromboembolism.
Dabigatran etexilate (Pradaxa) is the orally available prodrug of dabigatran, a potent compound belonging to the new class of nonpeptide direct thrombin inhibitors (DTIs). Following oral administration, dabigatran etexilate reached peak plasma concentrations within 2 hours, showed linear pharmacokinetics across a wide dose range, a linear relationship between ecarin clotting time (ECT) and international normalized ratio (INR), and no significant food or drug interactions. Dabigatran etexilate at once-daily doses of 150 mg and 220 mg has demonstrated non-inferiority to once-daily enoxaparin 40 mg for the prevention of venous thromboembolism (VTE) in patients undergoing total hip or knee replacement surgery in two large, randomized, double-blind clinical trials. The safety profile of dabigatran etexilate was similar to that of enoxaparin with comparable rates of major bleeding, liver enzyme elevation and acute coronary events. Oral availability of dabigatran etexilate, together with a rapid onset and offset of action and predictable anticoagulation response, makes this compound an attractive alternative to traditional anticoagulant therapies for the prevention of VTE.
Ferrer
Elisa
E
Medical Information Department, Thomson Reuters, Barcelona, Spain. scientific.prousjournals@thomsonreuters.com
D000925:Anticoagulants / Q000627:therapeutic use; D001562:Benzimidazoles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D000069604:Dabigatran; D006801:Humans; D011725:Pyridines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D054556:Venous Thromboembolism / Q000517:prevention & control*
D000925:Anticoagulants; D001562:Benzimidazoles; D011725:Pyridines; D000069604:Dabigatran