EEG topography-specific BOLD changes: a continuous EEG-fMRI study in a patient with focal epilepsy.
Blood oxygenation level dependent (BOLD) response related to interictal activity was evaluated in a patient with post-traumatic focal epilepsy at repeated continuous electroencephalogram (EEG)-functional magnetic resonance imaging examinations. Lateralized interictal EEG activity induced a main cluster of activation co-localized with the anatomical lesion. Spreading of EEG interictal activity to both frontal lobes evoked bilateral clusters of activation indicating that topography of BOLD response might depend on the spatial distribution of epileptiform activity.
Cosottini
Mirco
M
Department of Neuroscience University of Pisa, 56100 Pisa, Italy. mircocosottini@libero.it
Pesaresi
Ilaria
I
Maritato
Patrizia
P
Belmonte
Gina
G
Taddei
Arianna
A
Sartucci
Ferdinando
F
Mascalchi
Mario
M
Murri
Luigi
L
D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male