The genetics of albuminuria: from haplotype association mapping in mice to genetic causation in humans.
Genome-wide haplotype association mapping (HAM) in inbred mouse strains emerged as an efficient method for identifying novel quantitative trait loci for disease-related phenotypes. In this issue of Kidney International, Tsaih et al. present the results of the first HAM for age-related kidney damage in mice and examine the detected loci in the context of the human genome-wide association study for diabetic nephropathy.
Sterken
Roel
R
Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Kiryluk
Krzysztof
K
D000419:Albuminuria / Q000235:genetics*; D000818:Animals; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods*; D006239:Haplotypes; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D040641:Quantitative Trait Loci