title: [Advances in multidimensional high performance liquid chromatography for separation technology in proteomic study].
abstract: With the developments of proteomic study, multidimensional high performance liquid chromatography technology has attracted increasing interests due to its obvious advantages, such as rapid analysis, high automation and easy combination with mass spectrometry and so on. This review emphasizes the advances of multidimensional high performance liquid chromatography technology, including classical bottom-up methods, top-down techniques and array-based two-dimensional liquid chromatography system, which was designed and set up by our lab to improve the throughput. These techniques showed promising potential applications in proteomics study.
authors.affiliation: Department of Chemistry, Fudan University, Shanghai 200433, China.
authors.forename: Mingxia
authors.initials: M
authors.lastname: Gao
authors.forename: Xia
authors.initials: X
authors.lastname: Guan
authors.forename: Guangfeng
authors.initials: G
authors.lastname: Hong
authors.forename: Xiangmin
authors.initials: X
authors.lastname: Zhang
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D040901:Proteomics / Q000379:methods*