IGF-1, oxidative stress and atheroprotection.
Atherosclerosis is a chronic inflammatory disease in which early endothelial dysfunction and subintimal modified lipoprotein deposition progress to complex, advanced lesions that are predisposed to erosion, rupture and thrombosis. Oxidative stress plays a crucial role not only in initial lesion formation but also in lesion progression and destabilization. Although most growth factors are thought to promote vascular smooth muscle cell proliferation and migration, thereby increasing neointima, recent animal studies indicate that insulin-like growth factor (IGF)-1 exerts both pleiotropic anti-oxidant effects and anti-inflammatory effects, which together reduce atherosclerotic burden. This review discusses the effects of IGF-1 in models of vascular injury and atherosclerosis, emphasizing the relationship between oxidative stress and potential atheroprotective actions of IGF-1.
Higashi
Yusuke
Y
Tulane University School of Medicine, 1430 Tulane Avenue, SL 48, New Orleans, LA 70112, USA.
Sukhanov
Sergiy
S
Anwar
Asif
A
Shai
Shaw-Yung
SY
Delafontaine
Patrice
P
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D017209:Apoptosis; D050197:Atherosclerosis / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D004730:Endothelium, Vascular / Q000166:cytology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism / Q000627:therapeutic use*; D023421:Models, Animal; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D018384:Oxidative Stress; D013234:Stem Cells / Q000502:physiology
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D007334:Insulin-Like Growth Factor I