title: Bioactive alkaloids from the plant endophytic fungus Aspergillus terreus.
abstract: One new alkaloid, named 16 alpha-hydroxy-5 N-acetylardeemin ( 1), along with seven known metabolites ( 2- 8) was isolated from the fermentation broth of an endophytic fungus, ASPERGILLUS TERREUS. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis and by comparing spectroscopic data with those in the literature. Compound 1 displayed an inhibitory effect against acetylcholinesterase. Compounds 1- 8 also showed moderate or weak cytotoxic activity against KB and HSC-T6 cell lines.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, School of Lifesciences, Nanjing University, Nanjing, PR China.
authors.forename: Hui Ming
authors.initials: HM
authors.lastname: Ge
authors.forename: Hui
authors.initials: H
authors.lastname: Peng
authors.forename: Zhi Kai
authors.initials: ZK
authors.lastname: Guo
authors.forename: Jiang Tao
authors.initials: JT
authors.lastname: Cui
authors.forename: Yong Chun
authors.initials: YC
authors.lastname: Song
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D001681:Biological Assay; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000470:Alkaloids