title: Cerebrovascular physiology in perinates with congenital hydrocephalus.
abstract: OBJECTIVE
  This study investigated changes in regional cerebral blood flow (rCBF), autoregulation (AR), and mean CO(2) reactivity (CO(2)r) in nine neonates, who underwent cerebrospinal fluid (CSF) diversion for congenital hydrocephalus.
  
  
  METHODS
  During shunt insertion, a thermal diffusion probe inserted adjacent to the ventricular catheter in the right parietal region recorded rCBF. Changes in rCBF, mean arterial pressure, intracranial pressure (ICP), and expired CO(2) tension were recorded before and after removing CSF.
  
  
  RESULTS
  Mean baseline rCBF for the entire group was 19.5 mL/100 g/min (range 8.4-44.8), with a mean ICP of 9.9 mmHg (range 4-20). Following CSF removal, the rCBF increased significantly in two patients. Three patients demonstrated AR throughout their studies; one infant showed AR after CSF removal. One infant without AR during shunt insertion showed an increase in rCBF and AR during a revision 5 months later. Baseline CO(2)r varied considerably but was greater than two in two patients and increased in three other children after CSF removal. Mean follow-up was 23.6 months. One child, with severe developmental delay, died. Death or severe delay was associated with the absence of AR and a negative CO(2)r in three children. Normal or mild developmental delay was associated with AR and a neutral or positive CO(2)r in five patients.
  
  
  CONCLUSIONS
  Baseline levels of rCBF were not associated with developmental prognosis. AR and a positive CO(2)r were necessary but insufficient factors for normal development. The absence of AR and a negative CO(2)r were associated with poor prognosis.
authors.affiliation: Department of Neurosurgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA. WHanigan@umsmed.edu
authors.forename: William C
authors.initials: WC
authors.lastname: Hanigan
authors.forename: Donna
authors.initials: D
authors.lastname: Bogner
mesh_terms: D001794:Blood Pressure; D002245:Carbon Dioxide / Q000378:metabolism*; D002557:Cerebrospinal Fluid Shunts; D002560:Cerebrovascular Circulation; D002658:Developmental Disabilities / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006849:Hydrocephalus / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D007231:Infant, Newborn; D007427:Intracranial Pressure; D008297:Male; D010296:Parietal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology; D011379:Prognosis; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D002245:Carbon Dioxide