title: Long-term predictors of mortality and functional recovery after aortic valve replacement for severe aortic stenosis with left ventricular dysfunction.
abstract: OBJECTIVE
  At present, surgery is the only recommended effective treatment for severe aortic stenosis. However, the surgical risk is increased when left ventricular dysfunction is present. The aim of this study was to identify predictors of postoperative and long-term mortality and functional improvement after valve replacement in patients with severe aortic stenosis and left ventricular dysfunction.
  
  
  METHODS
  Between 1996 and 2008, 635 consecutive patients with severe aortic stenosis underwent surgery. Early postoperative mortality in the 82 with an ejection fraction <40% was 19.5%. The following independent predictors of early postoperative mortality were identified: female sex (odds ratio [OR]=2.60; 95% confidence interval [CI], 2.20-89.0; P=.004), mild mitral regurgitation (OR=2.38; 95% CI, 1.40-80.0; P=.020) and coronary artery disease (OR=2.09; 95% CI, 1.26-51.0; P=.027).
  
  
  RESULTS
  During the mean follow-up period of 42.59+/-40.83 months, overall mortality was 18.8% and cardiovascular mortality was 11.3%. The only factor associated with increased mortality during follow-up was a low postoperative cardiac output (OR=4.40; 95% CI, 1.20-15.5; P=.02). In total, 70.5% showed early improvement in ventricular function, the predictors of which were: no improvement following a previous myocardial infarction (P=.04), no revascularized coronary lesions (P=.04), and a low aortic valve pressure gradient (P=.02). Functional class improved significantly during follow-up in 93.4% of patients.
  
  
  CONCLUSIONS
  Despite considerable early postoperative mortality in patients with aortic stenosis and left ventricular dysfunction, over the long term there was evidence of better survival coupled to improved ventricular function and functional class.
authors.affiliation: Unidad del Corazón, Servicio de Cardiología y Cirugía Cardiaca, Hospital Universitario Virgen de la Victoria, Málaga, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Flores-Marín
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Gómez-Doblas
authors.forename: Juan
authors.initials: J
authors.lastname: Caballero-Borrego
authors.forename: Fernando
authors.initials: F
authors.lastname: Cabrera-Bueno
authors.forename: Isabel
authors.initials: I
authors.lastname: Rodríguez-Bailón
authors.forename: José M
authors.initials: JM
authors.lastname: Melero
authors.forename: Carlos
authors.initials: C
authors.lastname: Porras
authors.forename: Gema
authors.initials: G
authors.lastname: Sánchez-Espín
authors.forename: Miguel
authors.initials: M
authors.lastname: Such
authors.forename: Eduardo
authors.initials: E
authors.lastname: Olalla
authors.forename: Eduardo
authors.initials: E
authors.lastname: de Teresa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000150:complications / Q000401:mortality* / Q000601:surgery*; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality; D011379:Prognosis; D020127:Recovery of Function; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000150:complications