title: Toward the dynamic interactome: it's about time.
abstract: Dynamic molecular interactions play a central role in regulating the functioning of cells and organisms. The availability of experimentally determined large-scale cellular networks, along with other high-throughput experimental data sets that provide snapshots of biological systems at different times and conditions, is increasingly helpful in elucidating interaction dynamics. Here we review the beginnings of a new subfield within computational biology, one focused on the global inference and analysis of the dynamic interactome. This burgeoning research area, which entails a shift from static to dynamic network analysis, promises to be a major step forward in our ability to model and reason about cellular function and behavior.
authors.affiliation: National Center of Biotechnology Information, NLM, NIH, 8000 Rockville Pike, Bethesda MD 20814, USA. przytyck@ncbi.nlm.nih.gov
authors.forename: Teresa M
authors.initials: TM
authors.lastname: Przytycka
authors.forename: Mona
authors.initials: M
authors.lastname: Singh
authors.forename: Donna K
authors.initials: DK
authors.lastname: Slonim
mesh_terms: D011506:Proteins / Q000737:chemistry; D049490:Systems Biology
chemical_list: D011506:Proteins