[Response to hepatitis B vaccine in infants with mother-to-child HCV infection].
The aim of the study was to establish the vaccination-induced anti-HBs seroconversion in a group of children with mother-to-child HCV infection.


METHODS
105 infants born to HCV infected mothers were vaccinated against hepatitis B virus (10 microg/ml; 0, 1, 6 months). HCV infection (HCV-RNA RT-PCR, Abbot Laboratories, in serum positive infants detected twice in the first year of life) was confirmed in 18 (group A). 87 infants were HCV uninfected (group B). Anti-HBs titers (Ortho-EIA) were measured 1-6 months after the third dose of immunisation.


RESULTS
Seroconversion to anti-HBs >10 mIU/ml was achieved in 93 (88.6%) infants: 13/18 (73%) in group A, 80/87 (92%) in group B. Anti-HBs <10 mIU/ml was observed in 12 (11.3%) children: 5 (27%) in group A, and 7 (8%) in group B (p=0.04).


CONCLUSIONS
Response to hepatitis B vaccine in infants infected with HCV was weaker than in nonvaccinated infants.
Aniszewska
Małgorzata
M
Klinika Chorób Zakaźnych Wieku Dzieciecego, Warszawski Uniwersytet Medyczny, Wojewódzki Szpital Zakaźny w Warszawie, 01-201 Warszawa. malgorzata.aniszewska@wum.edu.pl
Kowalik-Mikołajewska
Barbara
B
Pokorska-Lis
Maria
M
D005260:Female; D006509:Hepatitis B / Q000276:immunology* / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006526:Hepatitis C / Q000276:immunology* / Q000635:transmission*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy
D017325:Hepatitis B Vaccines