title: Cataloging the Repertoire of Nature's Blowtorch, P450.
abstract: Veith et al. (2009) analyzed over 17,000 compounds for interaction with the five major human cytochrome P450 drug-metabolizing enzymes. Analysis of the results provides some structural insight and framework for expansion.
authors.affiliation: Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA.
authors.forename: F Peter
authors.initials: FP
authors.lastname: Guengerich
mesh_terms: D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D016208:Databases, Factual; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008024:Ligands; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D008024:Ligands; D003577:Cytochrome P-450 Enzyme System