A case of primary cutaneous senile EBV-related diffuse large B-cell lymphoma.
Epstein-Barr virus is known to be associated with the development of lymphomas in immunosuppressed patients. Recently, age-related immune impairment was recognized as a predisposing factor in the development of Epstein-Barr virus-driven lymphoproliferative processes in elderly patients. We describe the case of an otherwise healthy 84-year-old lady who developed a solitary primary cutaneous diffuse B-cell lymphoma on her leg in which the majority of the malignant cells had Epstein barr early RNA (EBER) and late membrane protein-1 expression, with in situ hybridization and immunohistochemistry, respectively.
Martin
Blanca
B
Department of Dermatopathology and Skin Tumour Unit, St. John's Institute of Dermatology, London, UK. blanca.martin@gstt.nhs.uk
Whittaker
Sean
S
Morris
Stephan
S
Robson
Alistair
A
D000367:Age Factors; D000369:Aged, 80 and over; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007866:Leg; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000378:metabolism / Q000821:virology*; D012367:RNA, Viral / Q000378:metabolism; D012867:Skin / Q000378:metabolism / Q000473:pathology / Q000821:virology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000821:virology*
D012367:RNA, Viral