title: [A case of small cell carcinoma of the esophagus with SIADH].
abstract: The patient was a 63-year-old male admitted for further evaluation of the bleeding esophageal tumor. Endoscopic biopsy revealed small cell carcinoma. CT scan of the abdomen demonstrated nodular enlargement at the celiac axis. Under diagnosis of small cell carcinoma of the esophagus at Stage IVa, neoadjuvant chemotherapy with FP (5-FU+CDDP) was given. Immediately after fluid load, levels of serum sodium decreased to 117 mEq/L and persisted during chemotherapy treatment despite aggressive corrections. Response and shrinkage of the distant nodal metastases were confirmed, and an esophagectomy was conducted. Pathological examination with IHC demonstrated positive staining for CD56, NSE and synaptophysin but negative for ADH. Lymph node and liver metastases recurred. Progression of the disease again triggered hyponatremia.
authors.affiliation: Department of Surgery, Shonantobu General Hospital, Japan.
authors.forename: Shohei
authors.initials: S
authors.lastname: Suzuki
authors.forename: Mio
authors.initials: M
authors.lastname: Goto
authors.forename: Takahide
authors.initials: T
authors.lastname: Okamoto
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tomita
authors.forename: Akihiro
authors.initials: A
authors.lastname: Murayama
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sawa
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Noguchi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Hoshikawa
authors.forename: Akio
authors.initials: A
authors.lastname: Shimizu
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000150:complications* / Q000628:therapy; D016629:Esophagectomy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy
chemical_list: D002945:Cisplatin; D005472:Fluorouracil