title: Pharmacokinetics of liposomal amphotericin B in pleural fluid.
abstract: We report the penetration of liposomal amphotericin B into the pleural fluid of a patient with pulmonary zygomycosis and empyema. The ratio of area under the concentration-versus-time curve in pleural fluid (AUC(pleural fluid)) to that in serum (AUC(serum)) for liposomal amphotericin B over 24 h was 9.4%, with pleural fluid concentrations of 2.12 to 4.91 microg/ml. Given the relatively low level of intrapleural penetration of liposomal amphotericin B, chest tube drainage may be warranted for successful treatment of zygomycotic empyema.
authors.affiliation: NIH Clinical Center Pharmacy Department, 10 Center Drive, Bethesda, MD 20892, USA. bmoriyama@cc.nih.gov
authors.forename: Brad
authors.initials: B
authors.lastname: Moriyama
authors.forename: Parizad
authors.initials: P
authors.lastname: Torabi-Parizi
authors.forename: Alexandra K
authors.initials: AK
authors.lastname: Pratt
authors.forename: Stacey A
authors.initials: SA
authors.lastname: Henning
authors.forename: Gennethel
authors.initials: G
authors.lastname: Pennick
authors.forename: Yvonne R
authors.initials: YR
authors.lastname: Shea
authors.forename: Sinchita
authors.initials: S
authors.lastname: Roy Chowdhuri
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rinaldi
authors.forename: A John
authors.initials: AJ
authors.lastname: Barrett
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D016724:Empyema, Pleural / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D006801:Humans; D008081:Liposomes; D008172:Lung Diseases, Fungal / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D008875:Middle Aged; D009091:Mucormycosis / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D010996:Pleural Effusion / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D008081:Liposomes; C068538:liposomal amphotericin B; D000666:Amphotericin B