title: Protein C and Protein S: causative factor for developing a hemorrhagic infarct in a HbE/Beta thalassemia child.
abstract: A 10-yr-old HbE/Beta thalassemia child who developed subacute to chronic occipitotemporal hemorrhagic infarct with smaller chronic infarct with gliotic changes in the left frontal periventricular white matter. Genetic tests showed that patient was positive for HbE and IVS1-5 mutation and was negative for thrombogenic mutations. Hemorrhagic infarct was confirmed by magnetic resonance imaging study. Antigenic levels of Protein C and Protein S were low. Based on these outcomes, it was concluded that Protein C and Protein S deficiency were the causative factor for developing hemorrhagic infarct in the HbE/Beta thalassemia patient.
authors.affiliation: Department of Hematology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Sharma
authors.initials: S
authors.lastname: Vineeta
authors.forename: Arijit
authors.initials: A
authors.lastname: Biswas
authors.forename: Bijender
authors.initials: B
authors.lastname: Kumar
authors.forename: Renu
authors.initials: R
authors.lastname: Saxena
mesh_terms: D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000209:etiology*; D002544:Cerebral Infarction / Q000175:diagnosis / Q000209:etiology*; D002648:Child; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020151:Protein C Deficiency / Q000150:complications / Q000175:diagnosis*; D018455:Protein S Deficiency / Q000150:complications / Q000175:diagnosis*; D017086:beta-Thalassemia / Q000150:complications*