title: What determines the later clinical course of patients who do not undergo colectomy at the first attack? A Japanese cohort study on ulcerative colitis.
abstract: OBJECTIVE
  Several earlier studies on factors predicting the long-term outcome of ulcerative colitis only encompassed treatment failure for one severe episode, or suffered from a lack of multivariate analyses. We aimed to identify factors assessable at diagnosis or after the first induction therapy which predicted relapse or later colectomy in patients with mild to severe ulcerative colitis.
  
  
  METHODS
  Clinical parameters (age, sex, disease extent, and disease activity at diagnosis) and laboratory data (hemoglobin, albumin, C-reactive protein, and erythrocyte sedimentation rate at diagnosis and 4 weeks after the first induction therapy) were evaluated in 296 patients (median follow-up 87 months). Factors predicting relapse and later colectomy were sought using the Cox proportional hazard model.
  
  
  RESULTS
  The presence of moderate or severe disease at diagnosis were significant predictors of relapse [adjusted hazard ratio (95% CI) 2.07 (1.48-2.89) and 1.70 (1.06-2.72), respectively] and later colectomy [3.40 (1.09-10.54) and 6.77 (1.92-23.86)]. After the first induction therapy, hemoglobin and albumin were associated with relapse [0.87 (0.76-0.99) and 0.58 (0.41-0.83)] and later colectomy [0.60 (0.47-0.77) and 0.11 (0.06-0.22)].
  
  
  CONCLUSIONS
  Relapse and later colectomy were associated with (1) disease activity at diagnosis and (2) lower levels of hemoglobin and albumin after the first induction therapy.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Aoba, Sendai, Japan. hshiga@mail.tains.tohoku.ac.jp
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shiga
authors.forename: Sho
authors.initials: S
authors.lastname: Takagi
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Inoue
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kinouchi
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Ohkubo
authors.forename: Seiichi
authors.initials: S
authors.lastname: Takahashi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Negoro
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yokoyama
authors.forename: Seiichi
authors.initials: S
authors.lastname: Kato
authors.forename: Kouhei
authors.initials: K
authors.lastname: Fukushima
authors.forename: Nobuo
authors.initials: N
authors.lastname: Hiwatashi
authors.forename: Tooru
authors.initials: T
authors.lastname: Shimosegawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015331:Cohort Studies; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012008:Recurrence; D012307:Risk Factors; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric