Trailing or paradoxical growth of Candida albicans when exposed to caspofungin is not associated with microsatellite genotypes.
Multilocus microsatellite polymorphisms in 27 clinical Candida albicans isolates were found to be clearly unrelated to in vitro paradoxical growth or trailing effect with caspofungin. These findings suggest that such in vitro phenotypes are either gained or lost too rapidly to be predicted by more stable genomic markers.
Khlif
Mohamed
M
Laboratoire de Biologie Moléculaire Parasitaire et Fongique, Faculté de Médecine de Sfax, Sfax, Tunisia.
Bogreau
Hervé
H
Michel-Nguyen
Annie
A
Ayadi
Ali
A
Ranque
Stéphane
S
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development*; D002177:Candidiasis / Q000382:microbiology; D000077336:Caspofungin; D054714:Echinocandins / Q000494:pharmacology*; D005838:Genotype; D006801:Humans; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D018895:Microsatellite Repeats / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin