Structure, phase behaviour and membrane interactions of N-acylethanolamines and N-acylphosphatidylethanolamines.
N-Acylethanolamines (NAEs) and N-acylphosphatidylethanolamines (NAPEs) are naturally occurring membrane lipids, whose content increases dramatically in a variety of organisms when subjected to stress, suggesting that they may play a role in the stress-combating mechanisms of organisms. In the light of this, it is of great interest to characterize the structure, physical properties, phase transitions and membrane interactions of these two classes of lipids. This review will present the current status of our understanding of the structure and phase behaviour of NAEs and NAPEs and their interaction with major membrane lipids, namely phosphatidylcholine, phosphatidylethanolamine and cholesterol. The relevance of such interactions to the putative stress-combating and membrane stabilizing properties of these lipids will also be discussed.
Swamy
Musti J
MJ
School of Chemistry, University of Hyderabad, Gachi Bowli, Andhra Pradesh, Hyderabad 500046, India. mjssc@uohyd.ernet.in
Tarafdar
Pradip K
PK
Kamlekar
Ravi Kanth
RK
D004983:Ethanolamines / Q000737:chemistry*; D008563:Membrane Lipids / Q000737:chemistry*; D015394:Molecular Structure
D004983:Ethanolamines; D008563:Membrane Lipids