title: Immune response and one-year antibody persistence after a fourth dose of a novel Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine (HibMenCY) at 12 to 15 months of age.
abstract: A total of 236 infants received a fourth Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine (HibMenCY) dose at 12 to 15 months. One month later, the proportion with anti-PRP antibody > or =1.0 microg/mL and bactericidal titers > or =1:8 to MenC and MenY was 98.9%, 96.9%, and 95.4%, respectively. One year later, anti-PRP concentrations > or =0.15 microg/mL, and MenC and MenY bactericidal titers > or =1:8 persisted in 100%, 96.6%, and 83.8%, respectively. The safety profile of HibMenCY was comparable to Hib.
authors.affiliation: Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY 40202, USA. gsmars01@louisville.edu
authors.forename: Gary S
authors.initials: GS
authors.lastname: Marshall
authors.forename: Colin D
authors.initials: CD
authors.lastname: Marchant
authors.forename: Mark
authors.initials: M
authors.lastname: Blatter
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Aris
authors.forename: Dominique
authors.initials: D
authors.lastname: Boutriau
authors.forename: Jan T
authors.initials: JT
authors.lastname: Poolman
authors.forename: Leonard R
authors.initials: LR
authors.lastname: Friedland
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Miller
mesh_terms: D000907:Antibodies, Bacterial / Q000276:immunology*; D018073:Haemophilus Vaccines / Q000009:adverse effects / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary / Q000379:methods*; D007223:Infant; D008137:Longitudinal Studies; D050296:Microbial Viability / Q000276:immunology; D013745:Tetanus Toxoid / Q000009:adverse effects / Q000276:immunology*; D013997:Time Factors; D014611:Vaccination / Q000379:methods*; D018074:Vaccines, Conjugate / Q000009:adverse effects / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D018073:Haemophilus Vaccines; C527605:Hib-MenCY-TT vaccine; D013745:Tetanus Toxoid; D018074:Vaccines, Conjugate