title: Utilization of myosin and actin bundles for the transport of molecular cargo.
abstract: The utilization of motor proteins for the movement and assembly of synthetic components is currently a goal of nanoengineering research. Application of the myosin actin motor system for nanotechnological uses has been hampered due to the low flexural rigidity of individual F-actin filaments. Here it is demonstrated how actin bundling can be used to affect the translational behavior of myosin-propelled filaments, transport molecules across a motor-patterned surface, and that the movement of bundled actin can be regulated photonically. These data suggest that actin bundling may significantly improve the applicability of the myosin motor for future nanotechnological applications.
authors.affiliation: Laboratory of Molecular Physiology, Robert C. Byrd Biotechnology Science Center, Department of Biological Sciences, Marshall University, Huntington, WV 25755-1090, USA.
authors.forename: Hideyo
authors.initials: H
authors.lastname: Takatsuki
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Rice
authors.forename: Shinichi
authors.initials: S
authors.lastname: Asano
authors.forename: B Scott
authors.initials: BS
authors.lastname: Day
authors.forename: Mizuki
authors.initials: M
authors.lastname: Hino
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Oiwa
authors.forename: Ryoki
authors.initials: R
authors.lastname: Ishikawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hiratsuka
authors.forename: Taro Q P
authors.initials: TQ
authors.lastname: Uyeda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kohama
authors.forename: Eric R
authors.initials: ER
authors.lastname: Blough
mesh_terms: D008841:Actin Cytoskeleton / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D000199:Actins / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects / Q000528:radiation effects; D002645:Chickens; D006576:Heterocyclic Compounds, 4 or More Rings / Q000494:pharmacology; D006801:Humans; D008027:Light; D009218:Myosins / Q000378:metabolism*; D053758:Nanoparticles / Q000737:chemistry; D011817:Rabbits
chemical_list: D000199:Actins; D006576:Heterocyclic Compounds, 4 or More Rings; C472645:blebbistatin; D009218:Myosins