title: Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and clinico-pathological and biological factors in invasive breast cancer.
abstract: BACKGROUND
  To investigate the relationship between the magnetic resonance imaging (MRI) features of breast cancer and its clinicopathological and biological factors.
  
  
  METHODS
  Dynamic MRI parameters of 68 invasive breast carcinomas were investigated. We also analyzed microvessel density (MVD), estrogen and progesterone receptor status, and expression of p53, HER2, ki67, VEGFR-1 and 2.
  
  
  RESULTS
  Homogeneous enhancement was significantly associated with smaller tumor size (T1: < 2 cm) (p = 0.015). Tumors with irregular or spiculated margins had a significantly higher MVD than tumors with smooth margins (p = 0.038). Tumors showing a maximum enhancement peak at two minutes, or longer, after injecting the contrast, had a significantly higher MVD count than those which reached this point sooner (p = 0.012). The percentage of tumors with vascular invasion or high mitotic index was significantly higher among those showing a low percentage (<or= 150%) of maximum enhancement before two minutes than among those ones showing a high percentage (>150%) of enhancement rate (p = 0.016 and p = 0.03, respectively). However, there was a significant and positive association between the mitotic index and the peak of maximum intensity (p = 0.036). Peritumor inflammation was significantly associated with washout curve type III (p = 0.042).
  
  
  CONCLUSIONS
  Variations in the early phase of dynamic MRI seem to be associated with parameters indicatives of tumor aggressiveness in breast cancer.
authors.affiliation: Unidad de Investigación, Hospital de Jove, Gijón-Spain.
authors.forename: Oscar
authors.initials: O
authors.lastname: Fernández-Guinea
authors.forename: Alejandro
authors.initials: A
authors.lastname: Andicoechea
authors.forename: Luis O
authors.initials: LO
authors.lastname: González
authors.forename: Salomé
authors.initials: S
authors.lastname: González-Reyes
authors.forename: Antonio M
authors.initials: AM
authors.lastname: Merino
authors.forename: Luis C
authors.initials: LC
authors.lastname: Hernández
authors.forename: Alfonso
authors.initials: A
authors.lastname: López-Muñiz
authors.forename: Paz
authors.initials: P
authors.lastname: García-Pravia
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Vizoso
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis; D007700:Kinetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008833:Microcirculation; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis; D011960:Receptors, Estrogen / Q000096:biosynthesis; D011980:Receptors, Progesterone / Q000096:biosynthesis; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000096:biosynthesis; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000096:biosynthesis
chemical_list: D019394:Ki-67 Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D016159:Tumor Suppressor Protein p53; D040281:Vascular Endothelial Growth Factor Receptor-1; D040301:Vascular Endothelial Growth Factor Receptor-2; C495901:TP53 protein, human; C508053:ERBB2 protein, human