title: The effect of repetitive transcranial magnetic stimulation on a model rat of Parkinson's disease.
abstract: This study was undertaken to investigate the neuroprotective effects of repetitive transcranial magnetic stimulation (rTMS) on 6-hydroxydopamine (6-OHDA)-induced rats with Parkinson's disease. rTMS was given to rats with Parkinson's disease induced by 6-OHDA, daily for 4 weeks to examine the protective effects. Rotational test showed that rTMS significantly attenuated apomorphine-induced turns in rats with Parkinson's disease. Tissue processing showed that rTMS alleviated 6-OHDA-induced loss of dopaminergic neurons in rat substantia nigra. Furthermore, rTMS decreased the levels of cyclooxygenase-2 and tumor necrosis factor-alpha in rat substantia nigra, and prevented the fall of dopamine in the striatum of rats with Parkinson's disease.
authors.affiliation: Department of Neurology, Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Yang
authors.forename: Lu
authors.initials: L
authors.lastname: Song
authors.forename: Zhenguo
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D002853:Chromatography, Liquid; D003342:Corpus Striatum / Q000378:metabolism*; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D018492:Dopamine Antagonists; D005260:Female; D008845:Microinjections; D009474:Neurons / Q000378:metabolism*; D016627:Oxidopamine; D010300:Parkinson Disease / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013378:Substantia Nigra / Q000378:metabolism*; D050781:Transcranial Magnetic Stimulation; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D018492:Dopamine Antagonists; D014409:Tumor Necrosis Factor-alpha; D016627:Oxidopamine; D051546:Cyclooxygenase 2; D004298:Dopamine