[Therapeutic effects of vinorelbine-based chemotherapy--retrospective study of 65 patients with metastatic or relapsed breast cancer].
METHODS
The subjects were 65 stage IV or relapsed breast cancer patients who received vinorelbine monotherapy or combination therapy at Fukushima Medical University between May 2002 and November 2006.


METHODS
Chemotherapy was divided into the following 3 groups Vinorelbine monotherapy (group A), Trastuzumab combination therapy (group B), MMVC (mitomycin C, methotrexate, vinorelbine and cyclophosphamide) therapy(group C).


RESULTS
There were 33 patients in group A, 15 patients in group B, and 17 patients in group C. The percentage of patients who had received more than 3 prior chemotherapy regimens were 69. 7% in group A, 66. 7% in group B, and 82. 4% in group C. No complete responses were observed. Partial responses was observed 6 patients in group A, 5 patients in group B, and 2 patients in group C. Overall response rate was 18. 2% in group A, 33. 3% in group B, and 11. 8% in group C. Clinical benefit rate was 24. 2% in group A, 46. 7% in group B, and 23. 5% in group C. The median overall survival time was 267, 522, and 275 days in group A, B, and C respectively.


CONCLUSIONS
Vinorelbine-based chemotherapy was considered as a new treatment option for patients with metastatic or relapsed breast cancer. It is necessary to examine the use at the early stage or more to obtain a high response rate and duration of response.
Watanabe
Kumiko
K
Department of Surgery 2, Fukushima Medical University, Fukushima, Japan.
Otake
Toru
T
Yasuda
Mitsuhiko
M
Takenoshita
Seiichi
S
D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D000068878:Trastuzumab; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077235:Vinorelbine
D000903:Antibiotics, Antineoplastic; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D000972:Antineoplastic Agents, Phytogenic; D016685:Mitomycin; D014747:Vinblastine; D000068878:Trastuzumab; D000077235:Vinorelbine; D008727:Methotrexate