title: [Detection of early organ dysfunction for the selection of treatment strategy on severe acute pancreatitis.].
abstract: OBJECTIVE
  To investigate the severity related influencing factor and treatment strategy of severe acute pancreatitis with early organ dysfunction.
  
  
  METHODS
  From July 2007 to December 2008, 167 patients with severe acute pancreatitis were treated in the Surgical Department of Ruijin Hospital. The relationships between the happening of early organ dysfunction and outcome of the patients were observed, with operative or nonoperative treatment strategy.
  
  
  RESULTS
  Among 167 patients, 68 patients have early organ dysfunction, in which 39 with single organ dysfunction and 29 with multiple organ dysfunction. The early organ dysfunction were involved in 47.1% in cardiovascular system, 35.3% in lung and 29.4% in kidney. Aging (P < 0.05) and higher APACHE II score (P < 0.05) predicted a poor prognosis, which were benefit from early operation.
  
  
  CONCLUSIONS
  The mortality of the patients with SAP is related to age, and the degree of organ dysfunction as well. In the first phase of the disease, the selection of operation depends on the trends and the degree of early organ dysfunction before infected necrosis happens, with the aid of SOFA score as a scale.
authors.affiliation: Department of Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China.
authors.forename: Yi-Fan
authors.initials: YF
authors.lastname: Lu
authors.forename: Ruo-Qing
authors.initials: RQ
authors.lastname: Lei
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Xu
authors.forename: Yang
authors.initials: Y
authors.lastname: Deng
authors.forename: Sheng
authors.initials: S
authors.lastname: Chen
authors.forename: Hong-Chang
authors.initials: HC
authors.lastname: Li
authors.forename: Chun-Yu
authors.initials: CY
authors.lastname: Chai
authors.forename: Tian-Quan
authors.initials: TQ
authors.lastname: Han
authors.forename: Yao-Qing
authors.initials: YQ
authors.lastname: Tang
authors.forename: Sheng-Dao
authors.initials: SD
authors.lastname: Zhang
mesh_terms: D000208:Acute Disease; D000375:Aging; D006801:Humans; D009102:Multiple Organ Failure; D010195:Pancreatitis / Q000175:diagnosis; D011379:Prognosis