title: [Optimization of solubilizing process of Qingkailing injection based on GA-BPNN modeling].
abstract: OBJECTIVE
  To optimize solubilizing process of Qingkailing injection.
  
  
  METHODS
  Uniform design experimental method and GA-BPNN modeling method were applied to optimize the technical parameters, and the solubility of cholic acid in medium was taken as optimizing index.
  
  
  RESULTS
  The type of solubilizer and pH of medium had greater impact on the index than the concentration for solubilizer. The optimum solubilizer was Tween-80. In a certain range the higher pH of medium was optimum; it was not necessary to use high-concentration solubilizer although there was positive correlation between the index and the concentration of solubilizer.
  
  
  CONCLUSIONS
  Uniform design combined with GA-BPNN modeling method is suitable for optimization of solubilizing process of Chinese materia medica injection, which has certain practical application value.
authors.affiliation: School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. liuruixin7@yahoo.com.cn
authors.forename: Ruixin
authors.initials: R
authors.lastname: Liu
authors.forename: Nancen
authors.initials: N
authors.lastname: Liu
authors.forename: Xinyuan
authors.initials: X
authors.lastname: Shi
authors.forename: Yanjiang
authors.initials: Y
authors.lastname: Qiao
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008419:Materia Medica / Q000737:chemistry*; D016571:Neural Networks, Computer; D012995:Solubility
chemical_list: D004365:Drugs, Chinese Herbal; D008419:Materia Medica; C504928:Qingkailing