A real-time, telemetric method for continuous measurement of portal pressures.
The ability to longitudinally monitor portal and splanchnic pressures would greatly enhance the understanding of acute and chronic liver disease by helping to assess the immediate and long-term impact of therapeutic manipulations. However, a technique for measuring portal pressures in the ambulatory setting is not currently available. To overcome this difficulty, we utilized an approach that involved the implantation of a miniature telemetric device, equipped with a specially-designed pressure transmission catheter, into the spleen of an anesthetized mouse. Using this approach, portal pressures were measured continuously over 5 d in conscious, unrestrained animals, the availability of which will help facilitate studies of the portal circulation requiring long-term stability.
Schwartz
Jason
J
Department of Surgery, University of Utah, Salt Lake City, Utah 84132, USA. jason.schwartz@hsc.utah.edu
Rohrwasser
Andreas
A
Hillas
Elaine
E
Hatch
Jenny
J
Sorensen
John
J
Gayowski
Timothy
T
Hutson
William
W
Lalouel
Jean-Marc
JM
D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D015918:Infusion Pumps, Implantable; D008107:Liver Diseases / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017082:Portal Pressure / Q000502:physiology*; D013152:Splanchnic Circulation / Q000502:physiology*; D013686:Telemetry / Q000295:instrumentation / Q000379:methods