Monocyte expression of adhesion molecules during low- and high-flux polysulfone hemodialysis and the effect of atorvastatin administration.
OBJECTIVE
Aims of the present study are to examine the effects of atorvastatin administration and the influence of membrane flux on adhesion molecules expression on monocytes.


METHODS
We studied CD11b, CD18 and CD62L expression on monocytes (flow cytometry) in 32 patients, 16 on low-flux (LFD) and 16 on high-flux (HFD) polysulfone hemodialysis, before and after dialysis and also after administration of atorvastatin 20 mg/day for 6 months.


RESULTS
After hemodialysis, expression of CD11b and CD18 increased and expression of CD62L decreased. After atorvastatin administration there was a decrease in pre-dialysis monocyte expression of CD11b and CD18, and an increase in the expression of CD62L compared to pre-dialysis baseline values. There were no statistically significant differences in expression of all three molecules between LFD and HFD groups.


CONCLUSIONS
Polysulfone dialysis process activates monocytes irrespectively of the membrane flux. Atorvastatin use is associated with reduced monocyte activation.
Stavroulopoulos
Aristeidis
A
Nephrology Department, IASIO Hospital - General Clinic of Kallithea, Athens, Greece. stavroulopoulos@yahoo.co.uk
Petras
Dimitrios
D
Kakavas
Ioannis
I
Agroyannis
Ioannis
I
Stamatelou
Kyriaki
K
Vyssoulis
Georgios
G
Papadakis
Ioannis T
IT
Stefanadis
Christodoulos
C
D000328:Adult; D000368:Aged; D000069059:Atorvastatin; D039481:CD11b Antigen / Q000096:biosynthesis; D018821:CD18 Antigens / Q000096:biosynthesis; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D018592:Cross-Over Studies; D005260:Female; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy; D019041:L-Selectin / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D011108:Polymers; D011758:Pyrroles / Q000627:therapeutic use*; D006435:Renal Dialysis / Q000295:instrumentation / Q000379:methods*; D013450:Sulfones
D039481:CD11b Antigen; D018821:CD18 Antigens; D015815:Cell Adhesion Molecules; D006538:Heptanoic Acids; C509295:ITGAM protein, human; D011108:Polymers; D011758:Pyrroles; D013450:Sulfones; D019041:L-Selectin; C017662:polysulfone P 1700; D000069059:Atorvastatin