Full genome analysis of an emerging cluster of human immunodeficiency virus type 1 subtype B infection in Hong Kong.
With considerable capacity for genetic diversification, new HIV-1 genotypes have been reported over the years. Three HIV-1 isolates previously genotyped as B using gag and env sequences were completely sequenced and reanalyzed. Several amino acid mutations were found in vif, rev, and nef genes but not in gag or env sequences. These alterations have not previously been reported in Hong Kong. The investigation of phylogenetic relatedness revealed that a region of the vif of the studied Hong Kong isolates subtype B cluster contains several subtype D signature amino acid residues. Several unique mutations on vif in these three isolates were also identified.
Tsui
Stephen K W
SK
Centre for Microbial Genomics and Proteomics, Hong Kong SAR. kwtsui@cuhk.edu.hk
Fong
Nga-Yin
NY
Li
Sai-Kam
SK
Leung
Ka-Kit
KK
Chan
Denise P C
DP
Chan
Paul K S
PK
Wong
Ka-Hing
KH
Lee
Shui-Shan
SS
D019943:Amino Acid Substitution / Q000235:genetics; D000818:Animals; D016000:Cluster Analysis; D016679:Genome, Viral; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D014764:Viral Proteins / Q000235:genetics
D014764:Viral Proteins