The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2.
Background. We studied the effect of fast induction of cardiac arrest with denosine on myocardial bax and bcl-2 expression. Methods and Results. 40 elective CABG patients were allocated into two groups. The adenosine group (n = 20) received 250 mug/kg adenosine into the aortic root followed by blood potassium cardioplegia. The control group received potassium cardioplegia in blood. Bcl-2 and bax were measured. Bax was reduced in the postoperative biopsies (1.38 versus 0.47, P = .002) in the control group. Bcl-2 showed a reducing tendency (0.14 versus 0.085, P = .07). After the adenosine treatment, the expression of both bax (0.52 versus 0.59, P = .4) and bcl-2 (0.104 versus 0.107, P = .4) remained unaltered after the operation. Conclusion. Open heart surgery is associated with rapid reduction in the expression of apoptosis regulating genes bax and bcl-2. Fast Adenosine induction abolished changes in their expression.
Shalaby
Ahmed
A
Division of Cardiothoracic Surgery, Heart Center, Pirkanmaa Hospital District, P.O. Box 2000, 33521 Tampere, Finland.
Rinne
Timo
T
Järvinen
Otso
O
Latva-Hirvelä
Juha
J
Nuutila
Kristiina
K
Saraste
Antti
A
Laurikka
Jari
J
Porkkala
Helena
H
Saukko
Pekka
P
Tarkka
Matti
M