[Safety and immunogenicity of lyophilized live attenuated domestic varicella vaccine].
OBJECTIVE
To evaluate the safety and immunogenicity of the lyophilized live attenuated domestic varicella vaccine of Oka strain in Zhejiang province.


METHODS
785 susceptible children aged 1-13 years, who had no history of VZV infection and had not been immunized, were observed. RESULTS The results showed that 2.29% children had adverse reactions after 30 mins of inoculation, 3.69% children had adverse reactions after 4 hours, 3.82% children had adverse reactions after 24 hours, 1.78% children had adverse reactions after 48 hours, 0.25% children had adverse reactions after 72 hours, no adverse reactions were observed after six weeks. There were 3.82% children had fever, The incidence rate of other adverse reactions such as swell and scleroma were low. The vaccine had high sero-converson rate.


CONCLUSIONS
The results showed that it has good safety and immunogenicity of the live attenuated domestic varicella vaccine.
Chen
En-Fu
EF
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China.
Jiang
Zheng-Gang
ZG
Li
Qian
Q
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D002644:Chickenpox / Q000097:blood / Q000276:immunology* / Q000821:virology; D019433:Chickenpox Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D002681:China; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005612:Freeze Drying; D006801:Humans; D007223:Infant; D008297:Male; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology
D000914:Antibodies, Viral; D019433:Chickenpox Vaccine; D014613:Vaccines, Attenuated