title: Response variability is associated with self-reported cognitive fatigue in multiple sclerosis.
abstract: Cognitive fatigue is a common, often debilitating symptom of multiple sclerosis (MS). Although MS patients frequently report that fatigue negatively affects cognitive functioning, most studies have found little evidence for a direct relationship between self-reported cognitive fatigue and traditional measures of neuropsychological functioning. The purpose of the present study was to examine the association between self-reported cognitive fatigue and a measure of response time variability (RTV). MS patients demonstrated significantly higher RTV than controls, and RTV was highly correlated with self-reported cognitive fatigue among relapsing-remitting and secondary progressive MS patients. Results highlight the need to implement newer methods to further elucidate the relationship between cognitive fatigue and neuropsychological functioning in MS.
authors.affiliation: Department of Psychology, University of Missouri-Kansas City, 5100 Rockhill Road, Kansas City, MO 64110, USA. Brucejm@umkc.edu
authors.forename: Jared M
authors.initials: JM
authors.lastname: Bruce
authors.forename: Amanda S
authors.initials: AS
authors.lastname: Bruce
authors.forename: Peter A
authors.initials: PA
authors.lastname: Arnett
mesh_terms: D000328:Adult; D001244:Association; D001288:Attention; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007360:Intelligence; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000523:psychology*; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000502:physiology*; D012649:Self Concept; D012919:Social Behavior; D013223:Statistics as Topic; D018709:Statistics, Nonparametric