title: Membrane organization and dynamics in cell polarity.
abstract: The establishment and maintenance of cell polarity is important to a wide range of biological processes ranging from chemotaxis to embryogenesis. An essential feature of cell polarity is the asymmetric organization of proteins and lipids in the plasma membrane. In this article, we discuss how polarity regulators such as small GTP-binding proteins and phospholipids spatially and kinetically control vesicular trafficking and membrane organization. Conversely, we discuss how membrane trafficking contributes to cell polarization through delivery of polarity determinants and regulators to the plasma membrane.
authors.affiliation: Department of Biology, University of Pennsylvania, Philadelphia, 19104-6018, USA.
authors.forename: Kelly
authors.initials: K
authors.lastname: Orlando
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
mesh_terms: D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D016764:Cell Polarity; D002633:Chemotaxis; D004023:Dictyostelium / Q000378:metabolism; D004331:Drosophila melanogaster; D005089:Exocytosis; D007700:Kinetics; D008055:Lipids / Q000737:chemistry*; D008954:Models, Biological; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism; D020691:rab GTP-Binding Proteins / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism
chemical_list: D015820:Cadherins; D008055:Lipids; D020764:cdc42 GTP-Binding Protein; D020691:rab GTP-Binding Proteins; D020741:rho GTP-Binding Proteins