Efficient one-pot synthesis of spirooxindole derivatives catalyzed by L-proline in aqueous medium.
An efficient one-pot synthesis of spirooxindole derivatives by three-component reaction of isatins, malononitrile (cyanoacetic ester) and 1,3-dicarbonyl compounds in water in the presence of l-proline is reported. This new protocol has the advantages of environmental friendliness, higher yields, shorter reaction times, low cost, and convenient operation.
Li
Yuling
Y
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
Chen
Hui
H
Shi
Chunling
C
Shi
Daqing
D
Ji
Shunjun
S
D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis*; D011392:Proline / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis*; D014867:Water
D007211:Indoles; D013141:Spiro Compounds; D014867:Water; D011392:Proline