title: [Evaluation of promoting effect of several transdermal enhancers with fuzzy matter-element model].
abstract: OBJECTIVE
  To investigate the utilization of fuzzy matter - element model in evaluating the promoting effects of transdermal enhancers.
  
  
  METHODS
  Paracetamol was used as drug model. Azone, menthol, camphor, oleic acid, clove oil, Schizonepeta tenuifolia oil and patchouli were used as transdermal enhancers. Transdermal absorption experimentation of paracetamol was detected on the device of penetrating skins of rabbit in vitro and penetrating rates, steady fluxs, lag time and enhancement ratio were calculated to evaluate promoting effects of transdermal enhancers with fuzzy matter-element model based on variation coefficient weight.
  
  
  RESULTS
  Paracetamol had the best promoting function with 2% clove oil and 2% camphor. The function drops slightly with 1% azone, 2% Schizonepeta tenuifolia oil, 2% menthol and 2% oleic acid ranked behind. The worst was with 2% patchouli.
  
  
  CONCLUSIONS
  Fuzzy matter-element model based on variation coefficient weight could judge the promoting and penetrating effect of transdermal enhancers objectively and feasible.
authors.affiliation: Department of Pharmacology of Traditonal Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zheng
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Kuoju
authors.initials: K
authors.lastname: Cheng
authors.forename: Qing
authors.initials: Q
authors.lastname: Liang
mesh_terms: D000082:Acetaminophen / Q000493:pharmacokinetics; D000277:Adjuvants, Pharmaceutic / Q000737:chemistry*; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D008954:Models, Biological; D011817:Rabbits; D012869:Skin Absorption
chemical_list: D000277:Adjuvants, Pharmaceutic; D000082:Acetaminophen