p38delta mitogen-activated protein kinase regulates skin  homeostasis and tumorigenesis.
The p38delta mitogen-activated protein kinase (MAPK) is abundantly expressed in a wide array of tissues where it is likely to have specific functions. This review aims to highlight recent new insights into the biological roles of this relatively less studied p38 isoform. We focus on function of p38delta in regulating of epidermal keratinocyte differentiation, apoptosis and skin tumor development.
Efimova
Tatiana
T
Division of Dermatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA. tefmova@im.wustl.edu
D000818:Animals; D006706:Homeostasis; D006801:Humans; D015603:Keratinocytes / Q000201:enzymology; D048292:Mitogen-Activated Protein Kinase 13 / Q000378:metabolism*; D011230:Precancerous Conditions / Q000201:enzymology*; D012867:Skin / Q000201:enzymology* / Q000473:pathology*; D012878:Skin Neoplasms / Q000201:enzymology* / Q000473:pathology
D048292:Mitogen-Activated Protein Kinase 13