title: Carcinoma developing in a fibroadenoma in a woman with a family history of breast cancer: a case report and review of literature.
abstract: BACKGROUND
  Malignant transformation of a fibroadenoma is rare with only about 100 cases reported in the world literature. Fibroadenoma occurring in middle aged woman with a strong family history of breast or ovarian cancer should be investigated with a high suspicion for malignancy.
  
  
  METHODS
  A 35-year- old Indian lady operated previously for fibroadenoma of the right breast presented with a recurrent lump at the same site. She had a strong family history of breast carcinoma. Mammography and trucut biopsy was suggestive of infiltrating duct carcinoma. She was managed by lumpectomy and axillary lymph node dissection with a satisfactory outcome. There was no evidence of BRCA-1, BRCA-2 mutation on immunohistochemistry.
  
  
  CONCLUSIONS
  Malignant change in a pre-existing fibroadenoma is rare, however in a middle aged woman with a family history of breast cancer it should be suspected. In the absence of any definite clinical and radiological criteria of diagnosing malignant change in a fibroadenoma, high suspicion index is mandatory. The management and outcome depends on the stage and grade of presentation.
authors.affiliation: Department of Surgery, Vardhman Mahavir Medical College, Safdarjang Hospital, New Delhi-110023, India.
authors.lastname: Chintamani
authors.forename: Rohan
authors.initials: R
authors.lastname: Khandelwal
authors.forename: Megha
authors.initials: M
authors.lastname: Tandon
authors.forename: K
authors.initials: K
authors.lastname: Yashwant
authors.forename: Pranjal
authors.initials: P
authors.lastname: Kulshreshtha
authors.forename: Tushar
authors.initials: T
authors.lastname: Aeron
authors.forename: Dinesh
authors.initials: D
authors.lastname: Bhatnagar
authors.forename: Anju
authors.initials: A
authors.lastname: Bansal
authors.forename: Sunita
authors.initials: S
authors.lastname: Saxena