Overexpression of AIB1 negatively affects survival of surgically resected non-small-cell lung cancer patients.
BACKGROUND
The amplified in breast cancer 1 (AIB1) gene has been considered to play an oncogenic role in human cancers, but its clinical/prognostic significance in non-small-cell lung cancer (NSCLC) is still unclear.


METHODS
The methods of immunohistochemistry and FISH were utilized to examine protein expression and amplification of AIB1 in 230 informative surgically resected NSCLCs and in 30 samples of normal lung tissues.


RESULTS
Overexpression and amplification of AIB1 were found in 48.3% and 8.2% of NSCLCs, respectively. AIB1 overexpression was associated with AIB1 gene amplification and cell proliferation but not related to estrogen receptor (ER)-alpha, ER-beta, progesterone receptor or androgen receptor status. A positive correlation between AIB1 overexpression and an ascending pathologic node stage in lung adenocarcinoma (ADC) was observed (P = 0.043). Univariate survival analysis demonstrated a significant association of AIB1 overexpression with shortened patient survival, especially for those with stage III disease (P < 0.001). Importantly, AIB1 expression was evaluated as the most significant predictor for survival in multivariate analysis (hazards ratio = 2.069, P < 0.001).


CONCLUSIONS
Overexpression of AIB1 might provide a selective advantage for lymph node metastasis of lung ADC and serve as a useful biomarker for poor prognosis for NSCLC patients.
He
L-R
LR
State Key Laboratory of Oncology in South China; Department of Radiotherapy.
Zhao
H-Y
HY
Department of Medical Oncology.
Li
B-K
BK
Department of Surgical Oncology, Cancer Center, Sun Yat-Sen University, Guangzhou.
Zhang
L-J
LJ
Department of Surgical Oncology, Cancer Center, Sun Yat-Sen University, Guangzhou.
Liu
M-Z
MZ
Department of Radiotherapy.
Kung
H-F
HF
State Key Laboratory of Oncology in South China.
Guan
X-Y
XY
State Key Laboratory of Oncology in South China.
Bian
X-W
XW
Department of Pathology, Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, China.
Zeng
Y-X
YX
State Key Laboratory of Oncology in South China.
Xie
D
D
State Key Laboratory of Oncology in South China. Electronic address: xied@mail.sysu.edu.cn.
D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D056921:Nuclear Receptor Coactivator 3 / Q000235:genetics*; D011379:Prognosis; D011944:Receptors, Androgen / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D015996:Survival Rate
D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C538866:NCOA3 protein, human; D056921:Nuclear Receptor Coactivator 3