title: Antinociceptive and anti-inflammatory effects of ethanolic extracts of Glycine max (L.) Merr and Rhynchosia nulubilis seeds.
abstract: The aim of this study was to assess the in vivo potential of ethanolic extracts of Glycine max (L.) Merr. (SoRiTae) and Rhynchosia nulubilis (Yak-Kong) seeds as natural anti-nociceptive and anti-inflammatory agents. To assess the anti-nociceptive and anti-inflammatory potential, the ethanolic extracts of SoRiTae and Yak-Kong seeds were tested in arachidonic acid-induced ear edema, carrageenan induced paw edema, formalin-induced licking time, acetic acid induced writhing and hot plate-induced thermal stimulation in mice. The administration of ethanolic extracts of SoRiTae and Yak-Kong seeds evoked a significant effect of anti-nociceptive and anti-inflammatory activities as compared to standards aminopyrine and indomethacin. The ear edema, paw edema, paw licking time, pain and writhes in mice were significantly reduced (p < 0.05) as compared to the control. The results obtained in this study indicate that both SoRiTae and Yak-Kong soybeans possesses potential anti-nociceptive and anti-inflammatory activities.
authors.affiliation: Korea Food Research Institute, Seongnam, Kyonggi, 463-746, Korea.
authors.forename: Joo Hyuk
authors.initials: JH
authors.lastname: Yim
authors.affiliation: Department of Biomedical Science, CHA University, Seongnam, Kyonggi, 463-836, Korea.
authors.forename: Ok-Hwan
authors.initials: OH
authors.lastname: Lee
authors.affiliation: Pohang Center for Evaluation of Biomaterials, Pohang 790-834, Korea.
authors.forename: Ung-Kyu
authors.initials: UK
authors.lastname: Choi
authors.affiliation: Korea Food Research Institute, Seongnam, Kyonggi, 463-746, Korea.
authors.forename: Young-Chan
authors.initials: YC
authors.lastname: Kim
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D000431:Ethanol / Q000737:chemistry; D007887:Fabaceae / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D059408:Pain Management; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D012639:Seeds / Q000737:chemistry / Q000378:metabolism; D013025:Glycine max / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D000431:Ethanol