title: Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps.
abstract: OBJECTIVE
  Metabolic syndrome and insulin resistance are associated with a higher risk of colon cancer. Non-alcoholic fatty liver disease (NAFLD) is regarded as a manifestation of metabolic syndrome in the liver. This investigation was initiated to determine whether NAFLD has a relationship to colorectal adenomatous polyps.
  
  
  METHODS
  We examined the 2917 participants who underwent a routine colonoscopy at Kangbuk Samsung Hospital in 2007. We divided the 2917 subjects into the adenomatous polyp group (n = 556) and the normal group (n = 2361). Anthropometric measurements, biochemical tests for liver and metabolic function, and abdominal ultrasonographs were assessed.
  
  
  RESULTS
  The prevalence of NAFLD was 41.5% in the adenomatous polyp group and 30.2% in the control group. By multiple logistic regression analysis, NAFLD was found to be associated with an increased risk of colorectal adenomatous polyps (odds ratio, 1.28; 95% confidence interval, 1.03-1.60). An increased risk for NAFLD was more evident in patients with a greater number of adenomatous polyps.
  
  
  CONCLUSIONS
  NAFLD was associated with colorectal adenomatous polyps. Further studies are needed to confirm whether NAFLD is a predictor for the development of colorectal adenomatous polyps and cancer.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, South Korea.
authors.forename: Sang Tae
authors.initials: ST
authors.lastname: Hwang
authors.forename: Yong Kyun
authors.initials: YK
authors.lastname: Cho
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Park
authors.forename: Hong Joo
authors.initials: HJ
authors.lastname: Kim
authors.forename: Dong Il
authors.initials: DI
authors.lastname: Park
authors.forename: Chong Il
authors.initials: CI
authors.lastname: Sohn
authors.forename: Woo Kyu
authors.initials: WK
authors.lastname: Jeon
authors.forename: Byung Ik
authors.initials: BI
authors.lastname: Kim
authors.forename: Kyoung Hee
authors.initials: KH
authors.lastname: Won
authors.forename: Wook
authors.initials: W
authors.lastname: Jin
mesh_terms: D018256:Adenomatous Polyps / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D005234:Fatty Liver / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D005235:Fatty Liver, Alcoholic / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications; D008875:Middle Aged; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D018709:Statistics, Nonparametric