Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation?
Hydrogen sulfide (H(2)S) is emerging as a physiological neuromodulator as well as a smooth muscle relaxant. We submit the first evidence that blood H(2)S levels are significantly lower in fasting blood obtained from type 2 diabetes patients compared with age-matched healthy subjects, and in streptozotocin-treated diabetic rats compared with control Sprague-Dawley rats. We further observed that supplementation with H(2)S or an endogenous precursor of H(2)S (l-cysteine) in culture medium prevents IL-8 and MCP-1 secretion in high-glucose-treated human U937 monocytes. These first observations led to the hypothesis that lower blood H(2)S levels may contribute to the vascular inflammation seen in diabetes.
Jain
Sushil K
SK
Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA.
Bull
Rebeca
R
Rains
Justin L
JL
Bass
Pat F
PF
Levine
Steven N
SN
Reddy
Sudha
S
McVie
Robert
R
Bocchini
Joseph A
JA
D000818:Animals; D001808:Blood Vessels / Q000187:drug effects* / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000139:chemically induced* / Q000276:immunology; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D006862:Hydrogen Sulfide / Q000097:blood* / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000009:adverse effects
D013311:Streptozocin; D005947:Glucose; D006862:Hydrogen Sulfide