title: What is positive appendicitis? A new answer to an old question. Clinical, macroscopical and microscopical findings in 200 consecutive appendectomies.
abstract: BACKGROUND
  The correlation between clinical and histopathology findings in appendicitis has been highlighted by many studies. However, the impact of this correlation on the surgical decision to remove a normal-looking appendix is still vague, with no clear definition of positive appendicitis. The aim of this study was to correlate the histological, operative and clinical diagnoses of acute appendicitis (AA).
  
  
  METHODS
  200 patients with a preoperative diagnosis of AA underwent laparoscopic appendectomy. A single consultant surgeon performed all the procedures. The clinical, macroscopical and microscopical outcomes were reported and analysed. Follow-up assessment was performed as an outpatient appointment.
  
  
  RESULTS
  112 women and 88 men were included in this study. The mean age was 18.8 (range 8-83) years. Macroscopical appendicitis was confirmed in 139 (69.5 percent) patients, while microscopical appendicitis was reported in 147 (73.5 percent) specimens of the appendix. Ten (7.2 percent) out of 139 patients who were macroscopically positive were found to have a normal appendix on microscopical examination. Different pathologies were found in 21 (10.5 percent) patients, and all underwent appendectomy. Microscopical appendicitis was confirmed in 10 (25 percent) out of 40 patients who had a normal-looking appendix.
  
  
  CONCLUSIONS
  The correlation of the clinical, microscopical and macroscopical findings in AA is important in order to understand the natural history of appendicitis, and this may help to formulate a sound surgical decision. These findings are supportive of justifying appendectomy for normal-looking appendices, if no other pathology is found.
authors.affiliation: Minimal Access Unit, Department of General Surgery, Princess Royal University Hospital, Farnborough Common, Orpington, BR6 8ND, Greater London, UK. azahrahussain@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Hussain
authors.forename: H
authors.initials: H
authors.lastname: Mahmood
authors.forename: T
authors.initials: T
authors.lastname: Singhal
authors.forename: S
authors.initials: S
authors.lastname: Balakrishnan
authors.forename: S
authors.initials: S
authors.lastname: El-Hasani
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001062:Appendectomy; D001064:Appendicitis / Q000473:pathology* / Q000601:surgery; D001065:Appendix / Q000473:pathology*; D002648:Child; D015331:Cohort Studies; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult