Application of biochemical markers in development of drugs for treatment of osteoarthritis.
Osteoarthritis is a chronic disease for which no efficacious medical intervention is yet available. Recent disappointments in late-stage clinical development of disease-modifying osteoarthritic drugs (DMOADs) have precipitated efforts in biomarker discovery aimed at developing an analytical tool box with the potential to improve the clinical development process. In this review, we seek to provide an overview of the biochemical marker repertoire currently available with a special focus on data originating from their application in clinical development programmes. Finally, we discuss possible directions in future biomarker research.
Qvist
Per
P
Nordic Bioscience A/S, Herlev, Denmark. pq@nordicbioscience.com
Christiansen
Claus
C
Karsdal
Morten A
MA
Madsen
Suzi Høgh
SH
Sondergaard
Bodil Cecilie
BC
Bay-Jensen
Anne-Christine
AC
D015415:Biomarkers; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D010003:Osteoarthritis / Q000175:diagnosis / Q000188:drug therapy*
D015415:Biomarkers