Toward the dynamic interactome: it's about time.
Dynamic molecular interactions play a central role in regulating the functioning of cells and organisms. The availability of experimentally determined large-scale cellular networks, along with other high-throughput experimental data sets that provide snapshots of biological systems at different times and conditions, is increasingly helpful in elucidating interaction dynamics. Here we review the beginnings of a new subfield within computational biology, one focused on the global inference and analysis of the dynamic interactome. This burgeoning research area, which entails a shift from static to dynamic network analysis, promises to be a major step forward in our ability to model and reason about cellular function and behavior.
Przytycka
Teresa M
TM
National Center of Biotechnology Information, NLM, NIH, 8000 Rockville Pike, Bethesda MD 20814, USA. przytyck@ncbi.nlm.nih.gov
Singh
Mona
M
Slonim
Donna K
DK
D011506:Proteins / Q000737:chemistry; D049490:Systems Biology
D011506:Proteins