title: Design strategies for the creation of artificial metalloenzymes.
abstract: In recent years, several complementary strategies have been implemented for the creation and optimization of artificial metalloenzymes. Selected examples outline the pros and cons of five different approaches: catalytic antibodies, computational design, directed evolution, artificial metal-cofactors and DNAzymes.
authors.affiliation: Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland.
authors.forename: Tillmann
authors.initials: T
authors.lastname: Heinisch
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Ward
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D032701:Biomimetics / Q000379:methods*; D019295:Computational Biology / Q000379:methods*; D006801:Humans; D008667:Metalloproteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data
chemical_list: D008667:Metalloproteins