Identification and quantitation of zopiclone in biological matrices using gas chromatography-mass spectrometry (GC-MS).
Zopiclone is a nonbenzodiazapine hypnotic used for the treatment of insomnia. Significant side effects include daytime drowsiness, dizziness, lightheadedness, bitter taste, dry mouth, headache, and upset stomach. A single method for confirmation and quantitation of zopiclone was developed for biological specimens and tissues. Zopiclone is extracted from the biological matrix using solid phase extraction technology. The drug is confirmed using gas chromatography mass spectrometry for toxicological and forensic purposes.
Rohrig
Timothy P
TP
Regional Forensic Science Center, Wichita, KS, USA.
Norton
Melissa C
MC
Harryman
Lydia A
LA
D053961:Azabicyclo Compounds / Q000032:analysis / Q000097:blood* / Q000652:urine*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D010879:Piperazines / Q000032:analysis / Q000097:blood* / Q000652:urine*; D052616:Solid Phase Extraction
D053961:Azabicyclo Compounds; D010879:Piperazines; C515050:zopiclone