Burkholdines 1097 and 1229, potent antifungal peptides from Burkholderia ambifaria 2.2N.
Potent antifungal cyclic lipopeptides, burkholdines (Bk), were isolated from a culture of Burkholderia ambifaria 2.2N. Bk-1229 (1) and Bk-1097 (2) are octapeptides comprised of nonproteinogenic amino acids, including beta-hydroxytyrosine, beta-hydroxyasparagine, and a new fatty acyl amino acid. 1 and 2 are fungicidal against a panel of fungi with potencies 2-60-fold better than amphotericin B control.
Tawfik
Kamilia A
KA
Department of Pharmacognosy, Suez Canal University, Ismailia, Egypt 41522.
Jeffs
Peter
P
Bray
Brian
B
Dubay
George
G
Falkinham
Joseph O
JO
Mesbah
Mostafa
M
Youssef
Diaa
D
Khalifa
Sherief
S
Schmidt
Eric W
EW
D000528:Alternaria / Q000187:drug effects; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects; D020171:Botrytis / Q000187:drug effects; D019117:Burkholderia / Q000737:chemistry*; D055666:Lipopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D055750:Phytophthora infestans / Q000187:drug effects
D000935:Antifungal Agents; D055666:Lipopeptides; C000718065:burkholdine