Directed evolution of gold nanoparticle delivery to cells.
A newly selected anti-receptor (anti-EGFR) aptamer was conjugated to gold nanoparticles via a facile hybridization method and was found to specifically and quantitatively direct the delivery of gold nanoparticles to cells expressing EGFR through receptor-mediated endocytosis.
Li
Na
N
Department of Chemistry and Biochemistry, Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA.
Larson
Timothy
T
Nguyen
Hong H
HH
Sokolov
Konstantin V
KV
Ellington
Andrew D
AD
D052157:Aptamers, Nucleotide / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D004705:Endocytosis; D066246:ErbB Receptors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry
D052157:Aptamers, Nucleotide; D006046:Gold; D066246:ErbB Receptors