Effects of glucosamine-chondroitin sulfate supplementation on serum fructosamine concentration in healthy dogs.
OBJECTIVE
To determine whether short-term administration of an oral glucosamine-chondroitin sulfate (Glu-CS) supplement alters serum fructosamine concentration in healthy dogs.


METHODS
Prospective crossover study.


METHODS
12 healthy adult dogs.


METHODS
Dogs received Glu-CS and a placebo for 3 weeks each, with a 4-week minimum washout period between treatments. Serum fructosamine concentration was measured 4 times for each dog: prior to the first treatment period, at the end of the first treatment period, at the end of the washout period, and at the end of the second treatment period.


RESULTS
No significant change in serum fructosamine concentration was identified after treatment with either Glu-CS or the placebo. The change in serum fructosamine concentration associated with Glu-CS administration was not significantly different from the change in concentration associated with administration of the placebo.


CONCLUSIONS
Results suggest that in healthy dogs, short-term (ie, 21 days) oral Glu-CS administration does not affect glycemic control or cause diabetes mellitus.
Lenox
Catherine E
CE
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Lunn
Katharine F
KF
D000284:Administration, Oral; D000818:Animals; D002809:Chondroitin Sulfates / Q000008:administration & dosage* / Q000378:metabolism; D004285:Dogs / Q000097:blood*; D004359:Drug Therapy, Combination; D019270:Fructosamine / Q000097:blood*; D005944:Glucosamine / Q000008:administration & dosage* / Q000378:metabolism; D008297:Male
D019270:Fructosamine; D002809:Chondroitin Sulfates; D005944:Glucosamine