title: Gold- and platinum-catalyzed formal Markownikoff's double hydroamination of alkynes: a rapid access to tetrahydroquinazolinones and angularly-fused analogues thereof.
abstract: A highly efficient gold(I)- and platinum(II)-catalyzed process for formal Markownikoff's double hydroamination of alkynes tethered with hydroxyl group has been developed. The method was shown to be applicable to a broad range of 2-aminobenzamides and alkynols leading to the formation of multiply substituted tetrahydroquinazolinones. Interestingly, when Pt(IV)Cl(4) catalyst was employed, cyclic angularly fused compound was obtained.
authors.affiliation: Organic Chemistry Division II, Indian Institute of Chemical Technology, Hyderabad 500 607, India. patilnitint@yahoo.com
authors.forename: Nitin T
authors.initials: NT
authors.lastname: Patil
authors.forename: Rahul D
authors.initials: RD
authors.lastname: Kavthe
authors.forename: Vivek S
authors.initials: VS
authors.lastname: Raut
authors.forename: Valmik S
authors.initials: VS
authors.lastname: Shinde
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Sridhar