title: Effects of structural differences between radioiodine-labeled 1-(2'-fluoro-2'-deoxy-D-arabinofuranosyl)-5-iodouracil (FIAU) and 1-(2'-fluoro-2'-deoxy-d-ribofuranosyl)-5-iodouracil (FIRU) on HSV1-TK reporter gene imaging.
abstract: The goal of this investigation was to evaluate the effects of structural differences between FIAU and FIRU on their ability to serve as a potential tracer for reporter gene imaging. To examine the characteristics of different configurations of FIAU and FIRU, a series of evaluations were done on HSV1-TK gene-expressing cells and on mice with HSV1-TK gene-expressing tumor. The results showed that, as an imaging agent for HSV1-TK-expressing cells, radiolabeled FIAU was more efficient for in vivo imaging than FIRU.
authors.affiliation: Radiopharmaceutical Research Team, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Republic of Korea.
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Kim
authors.forename: Su Hee
authors.initials: SH
authors.lastname: Hong
authors.forename: Tae Hyun
authors.initials: TH
authors.lastname: Choi
authors.forename: Eun Ah
authors.initials: EA
authors.lastname: Lee
authors.forename: Kyeong Min
authors.initials: KM
authors.lastname: Kim
authors.forename: Kyo Chul
authors.initials: KC
authors.lastname: Lee
authors.forename: Gwang Il
authors.initials: GI
authors.lastname: An
authors.forename: Mohammed I
authors.initials: MI
authors.lastname: El-Gamal
authors.forename: Gi Jeong
authors.initials: GJ
authors.lastname: Cheon
authors.forename: Chang Woon
authors.initials: CW
authors.lastname: Choi
authors.forename: Sang Moo
authors.initials: SM
authors.lastname: Lim
mesh_terms: D000818:Animals; D001086:Arabinofuranosyluracil / Q000031:analogs & derivatives* / Q000378:metabolism; D005467:Floxuridine / Q000031:analogs & derivatives / Q000378:metabolism; D017930:Genes, Reporter; D018259:Herpesvirus 1, Human / Q000201:enzymology*; D007457:Iodine Radioisotopes; D051379:Mice; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D007457:Iodine Radioisotopes; D014764:Viral Proteins; D005467:Floxuridine; D001086:Arabinofuranosyluracil; C043457:fialuridine; C059970:5-iodo-1-(2-fluoro-2-deoxyribofuranosyl)uracil; D011505:Protein-Tyrosine Kinases