Detection and management of late-onset 21-hydroxylase deficiency in women with hyperandrogenism.
Moderate forms of 21-hydroxylase deficiency (D21OH-NC), the so-called non-classical or late-onset forms are a frequently reported cause of hyperandrogenism in women [1-5]. The purpose of this collective and synthetic work was to provide the endocrinologist, gynecologist and dermatologist with consensual information so as to detect the maximum cases with acceptable cost-benefit ratio and to define the main lines of optimal patient management, given the data currently available in medical literature.
Young
J
J
Department of endocrinology and reproductive disorders, hôpital Bicêtre, 78 rue du Général-Leclerc, Le Kremlin Bicêtre, France. jacques.young@bct.aphp.fr
Tardy
V
V
de la Perrière
A-B
AB
Bachelot
A
A
Morel
Y
Y
D000312:Adrenal Hyperplasia, Congenital / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000235:genetics; D000309:Adrenal Insufficiency / Q000150:complications / Q000175:diagnosis; D003366:Cosyntropin; D005260:Female; D005817:Genetic Counseling; D005938:Glucocorticoids / Q000627:therapeutic use; D006628:Hirsutism / Q000209:etiology / Q000628:therapy; D020249:Hormone Replacement Therapy; D006801:Humans; D017588:Hyperandrogenism / Q000175:diagnosis / Q000188:drug therapy* / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D007247:Infertility, Female / Q000209:etiology; D013255:Steroid 21-Hydroxylase / Q000235:genetics
D005938:Glucocorticoids; D003366:Cosyntropin; D013255:Steroid 21-Hydroxylase