Awareness of glucose-6 phosphate-dehydrogenase deficiency in celiac disease.
Individuals with celiac disease (CD) are predisposed to a number of haematological abnormalities including anaemia secondary to malabsorption of iron, vitamin B12 or folate; anaemia of chronic disease and coagulopathy secondary to vitamin K deficiency. Correction of coagulopathy with vitamin K is necessary before endoscopic biopsy in patients with suspected CD. However, vitamin K causes haemolysis in glucose-6 phosphate-dehydrogenase deficiency.


CONCLUSIONS
When vitamin K administration becomes necessary for correction of coagulopathy in patients with CD; glucose-6 phosphate-dehydrogenase deficiency should be considered.
Hosnut
F O
FO
Department of Pediatric Gastroenterology, Hepatology and Nutrition, Başkent University Faculty of Medicine, Ankara, TurkeyObstetric and Children Hospital, Adana, TurkeyDepartment of Pediatric Hematology, Başkent University Faculty of Medicine, Ankara, Turkey.
Canan
O
O
Department of Pediatric Gastroenterology, Hepatology and Nutrition, Başkent University Faculty of Medicine, Ankara, TurkeyObstetric and Children Hospital, Adana, TurkeyDepartment of Pediatric Hematology, Başkent University Faculty of Medicine, Ankara, Turkey.
Özcay
F
F
Department of Pediatric Gastroenterology, Hepatology and Nutrition, Başkent University Faculty of Medicine, Ankara, TurkeyObstetric and Children Hospital, Adana, TurkeyDepartment of Pediatric Hematology, Başkent University Faculty of Medicine, Ankara, Turkey.
Özbek
N
N
Department of Pediatric Gastroenterology, Hepatology and Nutrition, Başkent University Faculty of Medicine, Ankara, TurkeyObstetric and Children Hospital, Adana, TurkeyDepartment of Pediatric Hematology, Başkent University Faculty of Medicine, Ankara, Turkey.
D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis / Q000178:diet therapy; D000075202:Contraindications; D055050:Diet, Gluten-Free; D016099:Endoscopy, Gastrointestinal; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications* / Q000175:diagnosis; D006461:Hemolysis; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D014812:Vitamin K; D014813:Vitamin K Deficiency / Q000188:drug therapy / Q000209:etiology
D014812:Vitamin K; D005954:Glucosephosphate Dehydrogenase