title: Catalytic asymmetric total synthesis of tangutorine.
abstract: The first enantioselective total synthesis of tangutorine has been achieved, wherein a Pd-catalyzed asymmetric allylic amination using a chiral diaminophosphine oxide (DIAPHOX) preligand was the key step.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-33, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Nemoto
authors.forename: Eri
authors.initials: E
authors.lastname: Yamamoto
authors.forename: Robert
authors.initials: R
authors.lastname: Franzén
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukuyama
authors.forename: Riliga
authors.initials: R
authors.lastname: Wu
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Fukamachi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Hamada
mesh_terms: D000498:Allyl Compounds / Q000737:chemistry; D000586:Amination; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004365:Drugs, Chinese Herbal / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D011807:Quinolizines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D002243:Carbolines; D004365:Drugs, Chinese Herbal; D011807:Quinolizines; C485396:tangutorine; D010165:Palladium