Cerebrospinal fluid apolipoprotein E concentration decreases after seizure.
OBJECTIVE
In epilepsy, many studies were focus on apoE gene polymorphism and found APOE epsilon4 to be associated with earlier onset of temporal lobe epilepsy. There is not any study about apoE in cerebrospinal fluid (CSF) of epileptic patients, so we detect the CSF-apoE and determine whether it is changed after seizure.


METHODS
A total of 60 epileptic patients and 28 subjects with no evidence of any neurological diseases were studied. The concentrations of CSF-apoE were detected with enzyme-linked immunosorbent assay.


RESULTS
The CSF-apoE levels in epilepsy and control group were 5.78+/-2.15 mg/l and 13.60+/-12.11 mg/l, and there were statistical difference. In epilepsy group, the CSF-apoE concentration was 6.53+/-2.55 mg/l in male patients, and 4.98+/-1.21 mg/l in female. In secondary epilepsy group was 5.06+/-1.31 mg/l, and in idiopathic epilepsy was 6.04+/-2.34 mg/l. In different seizure types groups, including complex partial seizure (CPS), secondarily generalized tonic-clonic seizure (SGTC), generalized tonic-clonic seizure (GTCS), and absence seizure (AS), the mean concentrations of CSF-apoE were 6.62+/-3.13 mg/l, 5.21+/-1.22 mg/l, 5.00+/-1.09 mg/l and 7.25+/-1.88 mg/l, respectively.


CONCLUSIONS
CSF-apoE concentration decreases after seizures, correlated with the gender, etiological factor and seizure types.
Wang
Liang
L
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, 1 You Yi Road, Chongqing 400016, China.
Han
Yanbing
Y
Chen
Dan
D
Xiao
Zheng
Z
Xi
Zhiqin
Z
Xiao
Fei
F
Wang
Xuefeng
X
D000293:Adolescent; D000328:Adult; D001057:Apolipoproteins E / Q000134:cerebrospinal fluid*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000134:cerebrospinal fluid*; D012737:Sex Factors; D055815:Young Adult
D001057:Apolipoproteins E