[Hairpin oligonucleotides as actinomycin carriers].
The redistribution of actinomycin from hairpin oligonucleotide HP1 to dissolved DNA and DNA inside the cell has been discovered and investigated. It was found that the penetration of the antibiotic in a complex with HP1 into cancer cells takes place more effectively than that of the antibiotic separately. It is suggested that hairpin oligonucleotides can serve as molecular carriers of heterocyclic antibiotics to cancer cells.
Vekshin
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NL
Savintsev
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IV
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism / Q000473:pathology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000235:genetics; D004273:DNA, Neoplasm / Q000378:metabolism; D003609:Dactinomycin / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D004337:Drug Carriers; D051379:Mice; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides
D000903:Antibiotics, Antineoplastic; D004273:DNA, Neoplasm; D004337:Drug Carriers; D009841:Oligonucleotides; D003609:Dactinomycin; C025942:7-aminoactinomycin D