title: Potential risk of bisphenol A migration from polycarbonate containers after heating, boiling, and microwaving.
abstract: The migration levels of bisphenol A (BPA) were analyzed in food samples by high-performance liquid chromatography (HPLC) from polycarbonate (PC) bottles subjected to simulated use by heating with microwave, heating in a boiling water bath, or filling them with boiling hot water (100 degrees C). Migration testing performed in PC bottles filled with steamed rice or hot cooked pork, standing at room temperature, or heated in a boiling water bath (100 degrees C) showed that BPA was not detected at the limit of detection (LOD) of 1 microg/L (ppb). In contrast, heating by microwaving to 100 degrees C for 9 min increased BPA migration levels from 6 to 18 ppb and from 5 to 15 ppb for steamed rice or for cooked pork, respectively. In addition, 3 different PC bottles were tested by filling them with boiling hot water (100 degrees C) and leaving them to stand at room temperature for up to 3 h. The mean BPA levels from the bottles increased in a time-dependent manner, with the range of not detected (ND) to 2.5 ppb after 60 min. However, none of the PC bottles released BPA at levels that exceed the recently established specific migration limits (SML) of 600 ppb established by European Union and Korea Food and Drug Administration (KFDA). Data suggest that the use of PC plastic bottles in our daily life is considered safe in Korea.
authors.affiliation: Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, South Korea.
authors.forename: Duck Soo
authors.initials: DS
authors.lastname: Lim
authors.forename: Seung Jun
authors.initials: SJ
authors.lastname: Kwack
authors.forename: Kyu-Bong
authors.initials: KB
authors.lastname: Kim
authors.forename: Hyung Sik
authors.initials: HS
authors.lastname: Kim
authors.forename: Byung Mu
authors.initials: BM
authors.lastname: Lee
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds; D003296:Cooking; D004968:Estrogens, Non-Steroidal / Q000737:chemistry / Q000633:toxicity; D005504:Food Analysis; D006358:Hot Temperature; D008460:Meat; D008872:Microwaves; D012275:Oryza; D010636:Phenols / Q000737:chemistry* / Q000633:toxicity; D011108:Polymers / Q000737:chemistry*; D019064:Product Packaging; D013552:Swine; D014867:Water / Q000737:chemistry*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D011108:Polymers; D014867:Water; C017902:lexan; C006780:bisphenol A; D000098826:Bisphenol A Compounds