Primary ocular presentation of sinonasal undifferentiated carcinoma.
The authors describe 2 consecutive patients who presented to Vanderbilt University Medical Center with primary orbital presentation of sinonasal undifferentiated carcinoma and were treated from July 2005 to April 2009. The patients were a 39-year-old woman and 54-year-old woman who both presented to the ophthalmology service due to complaints of diplopia. Imaging studies demonstrated large soft tissue masses originating in the sinuses with extension in the orbit in both cases. Both patients were treated with carboplatin, paclitaxel, and dexamethasone as induction chemotherapy followed by concurrent chemoradiation with intensity-modulated radiation therapy. This treatment regimen resulted in significant tumor shrinkage, resolution of symptoms, and no evidence of recurrence while avoiding surgical intervention and allowing orbital preservation.
Parbhu
Keshini C
KC
Department of Ophthalmology, University of Alabama, Birmingham, Alabama, USA. keshini.parbhu@yahoo.com
Galler
KoriAnne E
KE
Murphy
Barbara A
BA
Pitchford
Clovis W
CW
Mawn
Louise A
LA
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D002277:Carcinoma / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D017239:Paclitaxel / Q000008:administration & dosage; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D049268:Positron-Emission Tomography; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed
D003907:Dexamethasone; D016190:Carboplatin; D017239:Paclitaxel