Engineering static and dynamic control of synthetic pathways.
Maximizing the production of a desired small molecule is one of the primary goals in metabolic engineering. Recent advances in the nascent field of synthetic biology have increased the predictability of small-molecule production in engineered cells growing under constant conditions. The next frontier is to create synthetic pathways that adapt to changing environments.
Holtz
William J
WJ
Department of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA 94720, USA.
Keasling
Jay D
JD
D057005:Bioengineering; D004926:Escherichia coli / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D053858:Metabolic Networks and Pathways; D009876:Operon