[Effects of hydroxyzine on tolerance of facial mask during induction in children].
OBJECTIVE
To evaluate the effectiveness of hydroxyzine as a premedication agent for the acceptance of facial mask during induction of general anaesthesia in children.


METHODS
Prospective randomized single-blind study including ASA 1 and 2 children, aged between 1 and 9 years and undergoing outpatient surgery.


METHODS
Patients were randomly allocated to receive orally either 1mg/kg hydroxyzine (G1) or water 0.1 ml/kg (G2) one hour before induction of standardized inhalational anaesthesia. Tolerance of facial mask was assessed with a 3-points scale (good, moderate or poor). Chi-square and Student's t-test were used in statistical analysis; p values less than 0.05 were considered statistically significant.


RESULTS
One hundred patients were included (G1 = 49, G2 = 51). Demographic data were similar in both groups. Acceptance of facial mask was significantly better in G1 than in G2 (p = 0,002).


CONCLUSIONS
Hydroxyzine provided better acceptance of facial mask than placebo during induction of general anaesthesia in children.
Trifa
M
M
Service d'anesthésie-réanimation, hôpital d'Enfants, Tunis, Tunisie. mehditrifa@yahoo.fr
Khalifa
S Ben
SB
Gargouri
F
F
Kaouech
N
N
Friaa
M
M
D000284:Administration, Oral; D000556:Ambulatory Surgical Procedures; D000769:Anesthesia, Inhalation / Q000295:instrumentation / Q000523:psychology*; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006919:Hydroxyzine / Q000008:administration & dosage / Q000627:therapeutic use*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D008397:Masks; D011229:Preanesthetic Medication; D011446:Prospective Studies; D016037:Single-Blind Method
D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D006919:Hydroxyzine