title: Paltolides A--C, anabaenopeptin-type peptides from the palau sponge Theonella swinhoei.
abstract: Three new anabaenopeptin-like peptides, named paltolides A-C, were isolated from a deep-water specimen of the marine sponge Theonella swinhoei from Palau. Paltolides belong to a rare subgroup of sponge-derived anabaenopeptins that have in common a C-terminal tryptophan residue linked to the epsilon-amine of a lysine bearing a d configuration. The structures of paltolides A-C were determined by NMR and tandem MS techniques. Paltolide A is the first anabaenopeptin structure where a non-N-methylated amino acid precedes the C-terminal residue.
authors.affiliation: Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0820, USA.
authors.forename: Alberto
authors.initials: A
authors.lastname: Plaza
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Keffer
authors.forename: John R
authors.initials: JR
authors.lastname: Lloyd
authors.forename: Patrick L
authors.initials: PL
authors.lastname: Colin
authors.forename: Carole A
authors.initials: CA
authors.lastname: Bewley
mesh_terms: D000818:Animals; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047232:Theonella / Q000737:chemistry
chemical_list: D003603:Cytotoxins; D010456:Peptides, Cyclic; C548987:paltolide A; C548988:paltolide B; C548989:paltolide C