title: The natural history of fibroids.
abstract: OBJECTIVE
  Fibroids are common, hormone-dependent, benign uterine tumors. They can cause significant morbidity and the symptoms depend largely on their size. The aim of this study was to describe the natural history of fibroids and identify factors that may influence their growth.
  
  
  METHODS
  This was a retrospective longitudinal study of premenopausal women who were diagnosed with uterine fibroids on ultrasound examination. All women underwent at least two transvaginal ultrasound scans, which were all performed by a single operator. Fibroids were measured in three perpendicular planes and the mean diameter was calculated. The size and position of every individual fibroid was assessed and recorded on a computerized database. The volume of each fibroid was calculated using the formula for a sphere.
  
  
  RESULTS
  A total of 122 women were included in the study. Their median age at the initial examination was 40 (range, 27-45) years. Seventy-two (59.0%) were nulliparous and 74 (60.7%) had multiple fibroids. The median interval between the initial and final examination was 21.5 (range, 8-90) months. The median fibroid volume increased by 35.2% per year. Small fibroids (< 20 mm mean diameter) grew significantly faster than larger fibroids (P = 0.007). The median increase in size was significantly higher in cases of intramural fibroids (53.2 (interquartile range (IQR), 11.2-217)%) than in subserous fibroids (25.1 (IQR, 1.1-87.1)%) and submucous fibroids (22.8 (IQR, - 11.7 to 48.3)%) (P = 0.012). Multivariate analysis retained only fibroid size at presentation as an independent predictor of fibroid growth.
  
  
  CONCLUSIONS
  The growth of fibroids in premenopausal women is influenced by the tumor's size at presentation.
authors.affiliation: Gynaecology Diagnostic and Outpatient Treatment Unit, University College Hospital, London, UK.
authors.forename: D
authors.initials: D
authors.lastname: Mavrelos
authors.forename: J
authors.initials: J
authors.lastname: Ben-Nagi
authors.forename: T
authors.initials: T
authors.lastname: Holland
authors.forename: W
authors.initials: W
authors.lastname: Hoo
authors.forename: J
authors.initials: J
authors.lastname: Naftalin
authors.forename: D
authors.initials: D
authors.lastname: Jurkovic
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D018231:Leiomyomatosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D008137:Longitudinal Studies; D008875:Middle Aged; D017697:Premenopause; D011379:Prognosis; D012044:Regression Analysis; D012189:Retrospective Studies; D018570:Risk Assessment; D016896:Treatment Outcome; D047368:Tumor Burden; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology