Synthetic approaches to the 2008 new drugs.
New drugs are introduced to the market every year and each individual drug represents a privileged structure for its biological target. These new chemical entities (NCEs) provide insights into molecular recognition and also serve as leads for designing future new drugs. This review covers the syntheses of 18 NCEs marketed in 2008.
Liu
Kevin K-C
KK
Pfizer Inc, La Jolla, CA 92037, USA. Kevin.k.liu@pfizer.com
Sakya
Subas M
SM
O'Donnell
Christopher J
CJ
Li
Jin
J
D017277:Drug Approval; D006801:Humans; D008968:Molecular Conformation; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry / Q000145:classification
D004364:Pharmaceutical Preparations