title: Predicting outcomes in cervical cancer: a kinetic model of tumor regression during radiation therapy.
abstract: Applications of mathematical modeling can improve outcome predictions of cancer therapy. Here we present a kinetic model incorporating effects of radiosensitivity, tumor repopulation, and dead-cell resolving on the analysis of tumor volume regression data of 80 cervical cancer patients (stages 1B2-IVA) who underwent radiation therapy. Regression rates and derived model parameters correlated significantly with clinical outcome (P < 0.001; median follow-up: 6.2 years). The 6-year local tumor control rate was 87% versus 54% using radiosensitivity (2-Gy surviving fraction S(2) < 0.70 vs. S(2) > or = 0.70) as a predictor (P = 0.001) and 89% vs. 57% using dead-cell resolving time (T(1/2) < 22 days versus T(1/2) > or = 22 days, P < 0.001). The 6-year disease-specific survival was 73% versus 41% with S(2) < 0.70 versus S(2) > or = 0.70 (P = 0.025), and 87% vs. 52% with T(1/2) < 22 days versus T(1/2) > or = 22 days (P = 0.002). Our approach illustrates the promise of volume-based tumor response modeling to improve early outcome predictions that can be used to enable personalized adaptive therapy.
authors.affiliation: Department of Radiation Medicine, The Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Huang
authors.forename: Nina A
authors.initials: NA
authors.lastname: Mayr
authors.forename: William T C
authors.initials: WT
authors.lastname: Yuh
authors.forename: Simon S
authors.initials: SS
authors.lastname: Lo
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Montebello
authors.forename: John C
authors.initials: JC
authors.lastname: Grecula
authors.forename: Lanchun
authors.initials: L
authors.lastname: Lu
authors.forename: Kaile
authors.initials: K
authors.lastname: Li
authors.forename: Hualin
authors.initials: H
authors.lastname: Zhang
authors.forename: Nilendu
authors.initials: N
authors.lastname: Gupta
authors.forename: Jian Z
authors.initials: JZ
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D008954:Models, Biological; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000532:radiotherapy*