title: Plasma soluble corin in patients with heart failure.
abstract: BACKGROUND
  Corin is a transmembrane protease that processes natriuretic peptides in the heart. Like many membrane proteins, corin is shed from the cell surface.
  
  
  RESULTS
  In this study, we obtained plasma samples from healthy controls and patients with heart failure (HF) and acute myocardial infarction. Soluble corin levels in plasma were measured by an ELISA method. In healthy adults (n=198), plasma corin levels were 690 pg/mL (SD, 260 pg/mL). The corin levels did not differ significantly among different age groups. In patients with HF (n=291), plasma corin levels were significantly lower compared with that of healthy controls (365 pg/mL [SD, 259]; P<0.001). The reduction in plasma corin levels seemed to correlate with the severity of HF. In patients of New York Heart Association classes II, III, and IV, plasma corin levels were 450 pg/mL (SD, 281 pg/mL; n=69), 377 pg/mL (SD, 270 pg/mL; n=132), and 282 pg/mL (SD, 194 pg/mL; n=90), respectively (P<0.001 class II vs class IV; P<0.05 class III vs class IV). In contrast, plasma corin levels in patients with acute myocardial infarction (n=73) were similar to that of healthy controls (678 pg/mL [SD, 285 pg/mL]; P>0.05).
  
  
  CONCLUSIONS
  Soluble corin was detected in human plasma. Plasma corin levels were reduced significantly in patients with HF but not in those with acute myocardial infarction. Our results indicate that corin deficiency may contribute to the pathogenesis of HF and that plasma corin may be used as a biomarker in the diagnosis of HF.
authors.affiliation: Department of Cardiology, Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, Suzhou, China.
authors.forename: Ningzheng
authors.initials: N
authors.lastname: Dong
authors.forename: Shenghan
authors.initials: S
authors.lastname: Chen
authors.forename: Junhua
authors.initials: J
authors.lastname: Yang
authors.forename: Lizhen
authors.initials: L
authors.lastname: He
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Dongdong
authors.initials: D
authors.lastname: Zheng
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Zhou
authors.forename: Changgeng
authors.initials: C
authors.lastname: Ruan
authors.forename: Edward
authors.initials: E
authors.lastname: Plow
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D012697:Serine Endopeptidases / Q000097:blood*
chemical_list: D015415:Biomarkers; C119812:CORIN protein, human; D012697:Serine Endopeptidases