title: PSiFR: an integrated resource for prediction of protein structure and function.
abstract: In the post-genomic era, the annotation of protein function facilitates the understanding of various biological processes. To extend the range of function annotation methods to the twilight zone of sequence identity, we have developed approaches that exploit both protein tertiary structure and/or protein sequence evolutionary relationships. To serve the scientific community, we have integrated the structure prediction tools, TASSER, TASSER-Lite and METATASSER, and the functional inference tools, FINDSITE, a structure-based algorithm for binding site prediction, Gene Ontology molecular function inference and ligand screening, EFICAz(2), a sequence-based approach to enzyme function inference and DBD-hunter, an algorithm for predicting DNA-binding proteins and associated DNA-binding residues, into a unified web resource, Protein Structure and Function prediction Resource (PSiFR).
  
  
  METHODS
  PSiFR is freely available for use on the web at http://psifr.cssb.biology.gatech.edu/
authors.affiliation: Center for the Study of Systems Biology, School of Biology, Georgia Institute of Technology, Atlanta, GA 30318, USA.
authors.forename: Shashi B
authors.initials: SB
authors.lastname: Pandit
authors.forename: Michal
authors.initials: M
authors.lastname: Brylinski
authors.forename: Hongyi
authors.initials: H
authors.lastname: Zhou
authors.forename: Mu
authors.initials: M
authors.lastname: Gao
authors.forename: Adrian K
authors.initials: AK
authors.lastname: Arakaki
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Skolnick
mesh_terms: D001665:Binding Sites; D030562:Databases, Protein; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D012984:Software
chemical_list: D011506:Proteins