title: C(35)-terpenes from Bacillus subtilis KSM 6-10.
abstract: Four C(35)-terpenes (1-4) were isolated from a liquid culture of Bacillus subtilis KSM 6-10. Compounds 1 and 2, tetraprenyl-beta-curcumene and tetraprenyl-alpha-curcumene, respectively, were previously isolated from a spore preparation of the same species, whereas 3 and 4 are new C(35)-terpenols. The C(35)-terpenols (3 and 4) possess polycyclic skeletons. We propose that the C(35)-terpenols (3 and 4) are formed by cyclization of the acyclic C(35)-terpenes (1 and 2). Because only trace amounts of C(35)-terpenols 3 and 4 were found in the spore in contrast to the vegetative cells of B. subtilis KSM 6-10, it is assumed that the expression of terpene cyclase is not related to sporulation, as has been observed by other researchers in a different strain.
authors.affiliation: Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai, Haga, Tochigi 321-3497, Japan. takigawa.hirofumi@kao.co.jp
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Takigawa
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Sugiyama
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Shibuya
mesh_terms: D001412:Bacillus subtilis / Q000737:chemistry*; D019753:Intramolecular Lyases / Q000378:metabolism; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013171:Spores, Bacterial / Q000378:metabolism; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D012717:Sesquiterpenes; D013729:Terpenes; C086829:alpha-curcumene; D019753:Intramolecular Lyases