title: Mechanisms of chromosome behaviour during mitosis.
abstract: For over a century, scientists have strived to understand the mechanisms that govern the accurate segregation of chromosomes during mitosis. The most intriguing feature of this process, which is particularly prominent in higher eukaryotes, is the complex behaviour exhibited by the chromosomes. This behaviour is based on specific and highly regulated interactions between the chromosomes and spindle microtubules. Recent discoveries, enabled by high-resolution imaging combined with the various genetic, molecular, cell biological and chemical tools, support the idea that establishing and controlling the dynamic interaction between chromosomes and microtubules is a major factor in genomic fidelity.
authors.affiliation: Medical Sciences Program, Indiana University, Myers Hall 262, 915 East 3rd Street, Bloomington, Indiana, 47405, USA. cwalczak@indiana.edu
authors.forename: Claire E
authors.initials: CE
authors.lastname: Walczak
authors.forename: Shang
authors.initials: S
authors.lastname: Cai
authors.forename: Alexey
authors.initials: A
authors.lastname: Khodjakov
mesh_terms: D000818:Animals; D003585:Cell Biology; D002875:Chromosomes; D006801:Humans; D008870:Microtubules / Q000378:metabolism / Q000648:ultrastructure; D008938:Mitosis; D008941:Spindle Apparatus / Q000378:metabolism / Q000648:ultrastructure