title: Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity.
abstract: Several benzofuran derivatives linked to a 3-indoletetrahydropyridine through an alkyl chain were prepared and evaluated for serotonin transporter and 5-HT(1A) receptor affinities. Their design, synthesis and structure-activity relationships are described.
authors.affiliation: Chemical Sciences, Wyeth Research, Pearl River, NY 10965, United States.
authors.forename: Aranapakam M
authors.initials: AM
authors.lastname: Venkatesan
authors.forename: O
authors.initials: O
authors.lastname: Dos Santos
authors.forename: John
authors.initials: J
authors.lastname: Ellingboe
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Evrard
authors.forename: Boyd L
authors.initials: BL
authors.lastname: Harrison
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Smith
authors.forename: Rosemary
authors.initials: R
authors.lastname: Scerni
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Hornby
authors.forename: Lee E
authors.initials: LE
authors.lastname: Schechter
authors.forename: Terrence H
authors.initials: TH
authors.lastname: Andree
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000737:chemistry* / Q000378:metabolism*; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D011485:Protein Binding / Q000502:physiology; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D001572:Benzofurans; D050486:Serotonin Plasma Membrane Transport Proteins; D044282:Receptor, Serotonin, 5-HT1A; C105430:benzofuran