title: New radiobiological, radiation risk and radiation protection paradigms.
abstract: The long-standing conventional paradigm for radiobiology has formed a logical basis for the standard paradigm for radiation risk of cancer and heritable effects and, from these paradigms, has developed the internationally applied system for radiation protection, but with many simplifications, assumptions and generalizations. A variety of additional radiobiological phenomena that do not conform to the standard paradigm for radiobiology may have potential implications for radiation risk and radiation protection. It is suggested, however, that the current state of knowledge is still insufficient for these phenomena, individually or collectively, to be formulated systematically into a new paradigm for radiobiology. Additionally, there is at present lack of direct evidence of their relevance to risk for human health, despite attractive hypotheses as to how they might be involved. Finally, it remains to be shown how incorporation of such phenomena into the paradigm for radiation protection would provide sufficient added value to offset disruption to the present widely applied system. Further research should aim for better mechanistic understanding of processes such as radiation-induced genomic instability (for all radiation types) and bystander effects (particularly for low-fluence high-LET particles) and also priority should be given to confirmation, or negation, of the relevance of the processes to human health risks from radiation.
authors.affiliation: c/o Medical Research Council, Harwell, Didcot OX11 0RD, United Kingdom. Electronic address: d.goodhead@har.mrc.ac.uk.
authors.forename: Dudley T
authors.initials: DT
authors.lastname: Goodhead
mesh_terms: D024201:Bystander Effect; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008954:Models, Biological; D011829:Radiation Dosage; D011835:Radiation Protection; D011853:Radiobiology; D012306:Risk