Modified phenazines from an Indonesian Streptomyces sp.
Fractionation of the extract from the Indonesian Streptomyces sp. ICBB8198 as directed by the antibacterial activity delivered the known phenazine antibiotics griseoluteic acid (1a) and griseolutein A (1b), as well as two new phenazine derivatives (2 and 3). In addition, the known compounds spirodionic acid, dihydrosarkomycins, and 6-ethyl-4-hydroxy-3,5-dimethyl-2H-pyran-2-one (4a), along with the new pyrone 3,6-diethyl-4-hydroxy-5-methyl-2H-pyran-2-one (4b), were isolated. We report here the isolation, structure elucidation, and antibiotic activity of the new metabolites as well as a hypothetical pathway for the formation of the new phenazine derivatives.
Fotso
Serge
S
Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, USA.
Santosa
Dwi Andreas
DA
Saraswati
Rasti
R
Yang
Jongtae
J
Mahmud
Taifo
T
Zabriskie
T Mark
TM
Proteau
Philip J
PJ
D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D007214:Indonesia; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009089:Mucor / Q000187:drug effects; D010619:Phenazines / Q000737:chemistry / Q000302:isolation & purification*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry / Q000302:isolation & purification*
D010619:Phenazines