Regulating cancer stem cells the miR way.
A recent study in Nature Cell Biology, Wellner et al. (2009) identifies ZEB1, a known promoter of tumor invasion, as a negative regulator of miRNA clusters that target stem cell factors. These findings provide new insight into the network of transcription factors and miRNAs that regulate cancer stem cells.
Peter
Marcus E
ME
The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA. mpeter@uchicago.edu