title: Francis Tally and the discovery and development of tigecycline: a personal reminiscence.
abstract: For Francis Tally, both medicine and science were highly personal undertakings. Tally thought that emotional engagement was important in one's work and one's life, which were inseparable in his case. Indeed, Tally materially participated in no fewer than 4 programs that resulted in the approval and commercialization of novel antibiotics. These included piperacillin-tazobactam (which is currently the injectable antibiotic with the largest volume of sales worldwide) and daptomycin. This article focuses on the discovery and development of tigecycline.
authors.affiliation: Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA. steven.projan@novartis.com
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Projan
mesh_terms: D000900:Anti-Bacterial Agents / Q000266:history* / Q000627:therapeutic use; D017277:Drug Approval; D015195:Drug Design; D004345:Drug Industry; D024901:Drug Resistance, Multiple, Bacterial; D049673:History, 20th Century; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000266:history / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline