title: Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk.
abstract: To identify new risk variants for chronic lymphocytic leukemia (CLL), we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four new risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio (OR) = 1.39; P = 2.11 x 10(-9)), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 x 10(-10)), 15q21.3 (rs7169431; OR = 1.36; P = 4.74 x 10(-7)) and 16q24.1 (rs305061; OR = 1.22; P = 3.60 x 10(-7)). We also found evidence for risk loci at 15q25.2 (rs783540, CPEB1; OR = 1.18; P = 3.67 x 10(-6)) and 18q21.1 (rs1036935; OR = 1.22; P = 2.28 x 10(-6)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy.
authors.affiliation: Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: Dalemari
authors.initials: D
authors.lastname: Crowther-Swanepoel
authors.forename: Peter
authors.initials: P
authors.lastname: Broderick
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Di Bernardo
authors.forename: Sara E
authors.initials: SE
authors.lastname: Dobbins
authors.forename: María
authors.initials: M
authors.lastname: Torres
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Mansouri
authors.forename: Clara
authors.initials: C
authors.lastname: Ruiz-Ponte
authors.forename: Anna
authors.initials: A
authors.lastname: Enjuanes
authors.forename: Richard
authors.initials: R
authors.lastname: Rosenquist
authors.forename: Angel
authors.initials: A
authors.lastname: Carracedo
authors.forename: Jesper
authors.initials: J
authors.lastname: Jurlander
authors.forename: Elias
authors.initials: E
authors.lastname: Campo
authors.forename: Gunnar
authors.initials: G
authors.lastname: Juliusson
authors.forename: Emilio
authors.initials: E
authors.lastname: Montserrat
authors.forename: Karin E
authors.initials: KE
authors.lastname: Smedby
authors.forename: Martin J S
authors.initials: MJ
authors.lastname: Dyer
authors.forename: Estella
authors.initials: E
authors.lastname: Matutes
authors.forename: Claire
authors.initials: C
authors.lastname: Dearden
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Sunter
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Hall
authors.forename: Tryfonia
authors.initials: T
authors.lastname: Mainou-Fowler
authors.forename: Graham H
authors.initials: GH
authors.lastname: Jackson
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Summerfield
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Harris
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Pettitt
authors.forename: David J
authors.initials: DJ
authors.lastname: Allsup
authors.forename: James R
authors.initials: JR
authors.lastname: Bailey
authors.forename: Guy
authors.initials: G
authors.lastname: Pratt
authors.forename: Chris
authors.initials: C
authors.lastname: Pepper
authors.forename: Chris
authors.initials: C
authors.lastname: Fegan
authors.forename: Anton
authors.initials: A
authors.lastname: Parker
authors.forename: David
authors.initials: D
authors.lastname: Oscier
authors.forename: James M
authors.initials: JM
authors.lastname: Allan
authors.forename: Daniel
authors.initials: D
authors.lastname: Catovsky
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
mesh_terms: D000483:Alleles; D002877:Chromosomes, Human / Q000235:genetics*; D056426:Genetic Loci / Q000235:genetics; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D015894:Genome, Human / Q000235:genetics; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics