title: Indole as an intercellular signal in microbial communities.
abstract: Bacteria can utilize signal molecules to coordinate their behavior to survive in dynamic multispecies communities. Indole is widespread in the natural environment, as a variety of both Gram-positive and Gram-negative bacteria (to date, 85 species) produce large quantities of indole. Although it has been known for over 100 years that many bacteria produce indole, the real biological roles of this molecule are only now beginning to be unveiled. As an intercellular signal molecule, indole controls diverse aspects of bacterial physiology, such as spore formation, plasmid stability, drug resistance, biofilm formation, and virulence in indole-producing bacteria. In contrast, many non-indole-producing bacteria, plants and animals produce diverse oxygenases which may interfere with indole signaling. It appears indole plays an important role in bacterial physiology, ecological balance, and possibly human health. Here we discuss our current knowledge and perspectives on indole signaling.
authors.affiliation: School of Display & Chemical Engineering, Yeungnam University, Gyeongsan, Korea.
authors.forename: Jin-Hyung
authors.initials: JH
authors.lastname: Lee
authors.forename: Jintae
authors.initials: J
authors.lastname: Lee
mesh_terms: D001419:Bacteria / Q000254:growth & development / Q000378:metabolism*; D018407:Bacterial Physiological Phenomena; D018441:Biofilms / Q000254:growth & development; D024881:Drug Resistance, Bacterial; D015964:Gene Expression Regulation, Bacterial; D007211:Indoles / Q000378:metabolism*; D010957:Plasmids; D053038:Quorum Sensing; D015398:Signal Transduction; D014774:Virulence
chemical_list: D007211:Indoles; C030374:indole