title: Association of postprandial and fasting triglycerides with traits of the metabolic syndrome in the Metabolic Intervention Cohort Kiel.
abstract: OBJECTIVE
  Postprandial (pp) lipid metabolism is associated with insulin resistance and type 2 diabetes. In young men, pp triglycerides (TGs) are more strongly associated with traits of metabolic syndrome (MS) than fasting TGs. We established a cohort of middle-aged men selected for traits of MS and pp lipid metabolism to determine if fasting TGs or pp TGs are more closely related to MS.
  
  
  METHODS
  A total of 1558 men were characterized for MS. A total of 755 men underwent an oral metabolic tolerance test consisting of a standardized high-fat meal and an oral glucose tolerance test. Blood samples were drawn in the fasting state and hourly until 9 h to determine pp TGs and free fatty acids. Glucose and insulin were analyzed until 5 h pp.
  
  
  RESULTS
  In the overall cohort, 329 subjects (21.1%) had a complete MS based on the Adult Treatment Panel III criteria, and 650 subjects (41.7%) had a complete MS based on the International Diabetes Federation criteria. The association of pp TGs with MS parameters was not stronger than the association of fasting TGs with them. Pp TGs were independently associated with beta-cell function.
  
  
  CONCLUSIONS
  Pp TGs did not show a higher correlation with MS traits than fasting TGs. This finding is probably due to the high incidence of overweight subjects in this middle-aged cohort.
authors.affiliation: Institute of Physiology and Biochemistry of Nutrition, Federal Research Centre for Nutrition and Food, 24103 Kiel, Germany. drubin@1med.uni-kiel.de
authors.forename: Diana
authors.initials: D
authors.lastname: Rubin
authors.forename: Ulf
authors.initials: U
authors.lastname: Helwig
authors.forename: Michael
authors.initials: M
authors.lastname: Nothnagel
authors.forename: Ulrich R
authors.initials: UR
authors.lastname: Fölsch
authors.forename: Stefan
authors.initials: S
authors.lastname: Schreiber
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schrezenmeir
mesh_terms: D000886:Anthropometry; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure; D015331:Cohort Studies; D005215:Fasting / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D016014:Linear Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology*; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides