title: Advanced carcinoma of the prostatic urethra in a patient with marked response to chemotherapy, leading to preservation of the bladder.
abstract: We performed transurethral resection of the prostate (TUR-P) for a 66-year-old man with benign prostatic hyperplasia. Pathological examination diagnosed poorly differentiated urothelial carcinoma of the urethra with broad prostatic permeation. Random bladder biopsies showed no malignancy, but a second TUR-P revealed urothelial carcinoma in the prostate and bladder neck. Computed tomography (CT) showed lymph node metastases from para-aortic to right/left external iliac and left obturator nodes, so clinical stage T3N2M0 carcinoma of the prostatic urethra was diagnosed. Given the presence of lymph node metastases, neoadjuvant chemotherapy using cisplatin 70 mg/m(2), ifosfamide 1.2 g/m(2) and docetaxel 70 mg/m(2) (PIT) was considered. After chemotherapy, CT showed complete response (CR) of all lymph nodes. Local control in the bladder was considered to be good, so total prostatectomy and retroperitoneal lymph node dissection was selected instead of total cystoprostatectomy. Pathological findings of surgical specimens showed no residual carcinoma in the prostatic urethra or lymph nodes, although prostatic adenocarcinoma was recognized. No recurrences or metastases have been encountered as of 3 years and 5 months since surgery.
authors.affiliation: Department of Urology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan. hamasaki@nms.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hamasaki
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Kondo
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Ogata
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yoshida
authors.forename: Go
authors.initials: G
authors.lastname: Kimura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Taiji
authors.initials: T
authors.lastname: Nishimura
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D020360:Neoadjuvant Therapy; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000601:surgery; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D014523:Urethral Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery