title: Pathogen recognition by the cell surface receptor CD46 induces autophagy.
abstract: Autophagy is a degradative mechanism involved in cell protection against invading pathogens. Although the autophagic process is well characterized, the molecular pathways leading to its activation upon pathogen binding remain poorly understood. Our recent work demonstrates that the cell surface pathogen receptor CD46 induces autophagy upon pathogen recognition. The molecular pathway linking CD46 to the autophagosome machinery relies on the scaffold protein GOPC and on the autophagosome formation complex Beclin 1/VPS34. The CD46-dependent autophagy is critical to an early control of infection.
authors.affiliation: Université de Lyon, INSERM, U851, Université Lyon 1, IFR128, Lyon, France.
authors.forename: Grégory
authors.initials: G
authors.lastname: Meiffren
authors.forename: Pierre-Emmanuel
authors.initials: PE
authors.lastname: Joubert
authors.forename: Isabel Pombo
authors.initials: IP
authors.lastname: Grégoire
authors.forename: Patrice
authors.initials: P
authors.lastname: Codogno
authors.forename: Chantal
authors.initials: C
authors.lastname: Rabourdin-Combe
authors.forename: Mathias
authors.initials: M
authors.lastname: Faure
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism; D001343:Autophagy / Q000276:immunology*; D000071186:Beclin-1; D054884:Host-Pathogen Interactions; D051916:Membrane Cofactor Protein / Q000276:immunology*; D051379:Mice; D010588:Phagosomes / Q000378:metabolism
chemical_list: D051017:Apoptosis Regulatory Proteins; D000071186:Beclin-1; C115010:Becn1 protein, mouse; D051916:Membrane Cofactor Protein