title: [Chemotherapeutic wafers in treatment of malignant cerebral glioma. Assessment of a Cochrane review].
abstract: The present Cochrane review deals with implantation of chemotherapeutic wafers in the surgical cavity after resection of a malignant glioma. The authors found two controlled, randomised studies concerning this treatment modality after first-time surgical treatment and one study dealing with treatment of recurrent tumour. An effect was shown in the first with an increase in median survival of 2 months equivalent to the survival seen after standard (concomitant) treatment. No effect was shown in recurrent tumour.
authors.affiliation: Neurokirurgisk Afdeling NK 2092, Rigshospitalet, DK-2100 København Ø, Denmark. michael.kosteljanetz@rh.regionh.dk
authors.forename: Michael
authors.initials: M
authors.lastname: Kosteljanetz
authors.forename: Hans Skovgaard
authors.initials: HS
authors.lastname: Poulsen
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D002330:Carmustine / Q000008:administration & dosage*; D004343:Drug Implants; D019317:Evidence-Based Medicine; D005910:Glioma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D011379:Prognosis; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D004343:Drug Implants; D002330:Carmustine