title: One intraoperative dose of tranexamic Acid for patients having primary hip or knee arthroplasty.
abstract: BACKGROUND
  Multiple studies suggest tranexamic acid reduces blood loss and red cell transfusions in patients undergoing THA or TKA. However, many of the dosing schedules in these studies are not ideally suited for routine application.
  
  
  OBJECTIVE
  We asked whether one 20-mg per kg intraoperative dose of tranexamic acid in patients having primary THA or TKA would (1) decrease perioperative blood loss and red cell transfusion rates and (2) be a cost-effective protocol.
  
  
  METHODS
  We retrospectively reviewed the records of 234 patients operated on from April 1 to June 30, 2007 (before our study protocol) and 259 patients from April 1 to June 30, 2008 with the single-dose protocol. We then compared change in hemoglobin, transfusion rates, hemoglobin at discharge, hospital length of stay, and complications between the two groups. No other routine patient care practices or blood conservation program strategies were altered during this time.
  
  
  RESULTS
  We found a reduction in the decrease in hemoglobin in 2008 compared with 2007 for THA and TKA (39 from 46 g/L and 36 from 45 g/L, respectively),which led to a reduction in transfusion rates (3.6% from 13.5% and 2.0% from 13.4%, respectively) and higher hemoglobin levels at discharge [corrected].There were no recorded major adverse events associated with the introduction of this protocol.
  
  
  CONCLUSIONS
  One 20-mg per kg intraoperative dose of tranexamic acid reduced the perioperative decrease in hemoglobin and red blood cell transfusion rates in patients having TKA and THA compared with those of a similar cohort of patients in whom the protocol was not used. This weight increment dosing facilitated pharmacy drug preparation, led to minimal dose variability and wastage, and resulted in a substantial estimated cost savings.
  
  
  METHODS
  Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
authors.affiliation: Department of Anesthesia and Perioperative Medicine, University of Western Ontario, London, ON, Canada.
authors.forename: Fiona E
authors.initials: FE
authors.lastname: Ralley
authors.forename: Donna
authors.initials: D
authors.lastname: Berta
authors.forename: Valerie
authors.initials: V
authors.lastname: Binns
authors.forename: James
authors.initials: J
authors.lastname: Howard
authors.forename: Douglas D R
authors.initials: DD
authors.lastname: Naudie
mesh_terms: D000933:Antifibrinolytic Agents / Q000191:economics / Q000627:therapeutic use*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects* / Q000191:economics; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects* / Q000191:economics; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001803:Blood Transfusion / Q000191:economics; D016527:Drug Costs; D006488:Hemostasis, Surgical; D006801:Humans; D007430:Intraoperative Care; D012189:Retrospective Studies; D014148:Tranexamic Acid / Q000191:economics / Q000627:therapeutic use*
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid