[Expression of mammary serine proteinase inhibitor in oral squamous cell carcinoma and its clinical significance].
OBJECTIVE
To investigate the expression of mammary serine proteinase inhibitor(Maspin) in patients with oral squamous cell carcinoma and its relationship with clinicopathological features.


METHODS
The Maspin protein expression was examined in 45 patients with oral squamous cell carcinoma and in non-malignant oral epithelia by immunohistochemical staining. The relationship between the Maspin protein expression and the clinicopathological parameters was statistically analyzed.


RESULTS
The Maspin protein expression in the cancerous tissues of oral squamous cell carcinoma was lower than that in the non-malignant oral epithelia (P = 0.001). Negative correlation was found between the Maspin protein expression in cancerous tissue and the status of lymph node metastasis (P = 0.038). Positive Maspin protein expression indicated negative lymph node metastasis, and negative correlation was also found between the Maspin protein expression and the postoperative metastasis (P = 0.004). Positive correlation was found between the Maspin expression and the patients' survival rate (P = 0.014), patients with positive Maspin protein expression having higher survival rate than those with negative Maspin expression.


CONCLUSIONS
Maspin might be useful as a potential prognostic marker for oral squamous cell carcinoma.
Luo
Jun
J
Department of Oral and Maxillofacial Surgery, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Zhou
Lan
L
Zheng
Gen-jian
GJ
Ji
Tong
T
Zhong
Lai-ping
LP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D015842:Serine Proteinase Inhibitors / Q000378:metabolism*; D015843:Serpins / Q000378:metabolism*
C085344:SERPIN-B5; D015842:Serine Proteinase Inhibitors; D015843:Serpins