OGG1 Ser326Cys polymorphism and susceptibility to esophageal cancer in low and high at-risk populations of northern India.
BACKGROUND
Esophageal cancer has diverse incidence worldwide, and genetic/environmental risk factors are supposed to be responsible for it. OGG1 Ser326Cys gene polymorphism (rs1052133) has been found to be associated with different cancer susceptibilities and interaction with different environmental factors.


OBJECTIVE
The aim of this study is to detect the role of OGG1 Ser326Cys polymorphism in susceptibility to esophageal cancer in two Northern Indian populations having different incidence rates.


METHODS
A total of 737 cases and controls from two high and low at-risk populations were selected for the study. All the subjects were genotyped by PCR with confronting two-pair primers.


RESULTS
No significant association was found between OGG1 Ser326Cys genotypes and esophageal cancer risk in both of the populations. Gene-environment analysis revealed no significant interaction between OGG1 Ser326Cys genotypes and smoking/high-salted tea intake habits.


CONCLUSIONS
OGG1 Ser326Cys polymorphism does not have a role in determining susceptibility to esophageal cancer either in high or in low at-risk populations of Northern India.
Upadhyay
Rohit
R
Department of Genetics, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Raebareilly Road, Lucknow, 226014, India.
Malik
Manzoor Ahmed
MA
Zargar
Showkat Ali
SA
Mittal
Balraj
B
D000368:Aged; D016022:Case-Control Studies; D045647:DNA Glycosylases / Q000032:analysis / Q000235:genetics*; D017931:DNA Primers; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007194:India / Q000453:epidemiology; D007407:Interviews as Topic; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors
D017931:DNA Primers; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human