title: Aire, master of many trades.
abstract: In thymic epithelial cells, the protein Aire (autoimmune regulator) induces the ectopic expression of hundreds of peripheral tissue antigens, thus enlarging the repertoire of antigens available for the induction of central T cell tolerance. By analyzing Aire's interacting partners, Abramson et al. (2010) shed new light on this unorthodox form of gene expression.
authors.affiliation: Division of Developmental Immunology, Tumor Immunology Program, German Cancer Research Center, Heidelberg 69120, Germany. b.kyewski@dkfz.de
authors.forename: Bruno
authors.initials: B
authors.lastname: Kyewski
authors.forename: Pärt
authors.initials: P
authors.lastname: Peterson
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000235:genetics* / Q000276:immunology; D002460:Cell Line; D005786:Gene Expression Regulation; D006801:Humans; D007108:Immune Tolerance; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology*; D014157:Transcription Factors / Q000378:metabolism*; D000096927:AIRE Protein
chemical_list: D001324:Autoantigens; D014157:Transcription Factors; D000096927:AIRE Protein