title: Immunoglobulin levels of vitiligo patients.
abstract: In the present study, the serum immunoglobulin profiles of vitiligo patients were compared with that of cohort control and evaluated the correlation between immunoglobulin level with their socioeconomic factors and nutritional status. Thirty vitiligo patients were recruited randomly from the Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University Hospital, Dhaka, Bangladesh for this study. Thirty healthy individuals as control group matched by age, sex, education and socioeconomic factors to the patient group were selected. Serum immunoglobulin concentrations were determined by turbidimetry method using immunoglobulin kit. The concentration of IgG and IgA decreased significantly (P<0.05), but the change of IgM was not significant. Socioeconomic data revealed that most of the patients were young and female. Moreover statistical analysis revealed that there was significant correlation between immunoglobulin (IgG and IgA only) concentrations and BMI and number of depigmented patches with IgG concentrations. Finally it can be concluded that the change of serum immunoglobulin concentration in vitiligo patients could be due to the disease condition as pathomechanism suggested the aberrations in cellular immunity. But study with larger number of population is required for further evaluation of the relationship between the immune response and disease state to confirm these findings.
authors.affiliation: Department of Dermatology, Bangabandhu Sheikh Mujib Medical University, Dhaka-1000, Bangladesh.
authors.forename: Rubaiya
authors.initials: R
authors.lastname: Ali
authors.forename: Mohammad Shamsul
authors.initials: MS
authors.lastname: Ahsan
authors.forename: Mohammad Abul Kalam
authors.initials: MA
authors.lastname: Azad
authors.forename: Md Ashik
authors.initials: MA
authors.lastname: Ullah
authors.forename: Wasimul
authors.initials: W
authors.lastname: Bari
authors.forename: Sheikh Nazrul
authors.initials: SN
authors.lastname: Islam
authors.forename: Sabina
authors.initials: S
authors.lastname: Yeasmin
authors.forename: Abul
authors.initials: A
authors.lastname: Hasnat
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012959:Socioeconomic Factors; D014820:Vitiligo / Q000276:immunology*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M