In vitro activities of eight antifungal drugs against 55 clinical isolates of Fonsecaea spp.
The in vitro activities of eight antifungal drugs against clinical isolates of Fonsecaea pedrosoi (n = 21), Fonsecaea monophora (n = 25), and Fonsecaea nubica (n = 9) were tested. The resulting MIC(90)s for all strains (n = 55) were as follows, in increasing order: posaconazole, 0.063 microg/ml; itraconazole, 0.125 microg/ml; isavuconazole, 0.25 microg/ml; voriconazole, 0.5 microg/ml; amphotericin B, 2 microg/ml; caspofungin, 2 microg/ml; anidulafungin, 2 microg/ml; and fluconazole, 32 microg/ml.
Najafzadeh
Mohammad J
MJ
CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.
Badali
Hamid
H
Illnait-Zaragozi
Maria Teresa
MT
De Hoog
G Sybren
GS
Meis
Jacques F
JF
D000666:Amphotericin B / Q000494:pharmacology; D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects* / Q000302:isolation & purification; D000077336:Caspofungin; D002862:Chromoblastomycosis / Q000188:drug therapy* / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology; D015725:Fluconazole / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D017964:Itraconazole / Q000494:pharmacology; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D009570:Nitriles / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology; D065819:Voriconazole
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D009570:Nitriles; D011725:Pyridines; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; C508735:isavuconazole; C101425:posaconazole; D000666:Amphotericin B; D015725:Fluconazole; D000077612:Anidulafungin; D000077336:Caspofungin; D065819:Voriconazole