Novel 4,4'-diether-2,2'-bipyridine cisplatin analogues are more effective than cisplatin at inducing apoptosis in cancer cell lines.
The synthesis and characterization of dichloro(4,4'-bis[methoxy]-2,2'-bipyridine)platinum (1) and dichloro(4,4'-bis[3-methoxy-n-propyl]-2,2'-bipyridine)platinum (2) are described. As analogues to CDDP, these 4,4'-disubstituted 2,2'-bipyridine complexes exhibit decreased EC(50) values of 10-100 times in cancer cell lines of the lung, prostate, and melanoma with several combinations of complex and cell line less than 10 microM. Flow cytometry data indicate 'blocks' of MDA-MD-435 cycle by 1 (G2/M) and 2 (S). Observed cell survival trends in the presence of 1, 2 under ionizing radiation mimic those of CDDP. Preliminary structure activity relationships are discussed for the 4,4'-substitutions made on the bipyridine ring.
Vo
Van
V
Department of Chemistry, University of Nevada, Las Vegas, 4505 Maryland Parkway, Box 454003, Las Vegas, NV 89154-4003, United States.
Kabuloglu-Karayusuf
Zeynep G
ZG
Carper
Stephen W
SW
Bennett
Byron L
BL
Evilia
Caryn
C
D015082:2,2'-Dipyridyl / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002277:Carcinoma / Q000188:drug therapy; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000737:chemistry* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008545:Melanoma / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy*; D011471:Prostatic Neoplasms / Q000188:drug therapy
D015082:2,2'-Dipyridyl; D002945:Cisplatin