title: Analysis of cytokine pattern in exhaled breath condensate of lung  transplant recipients with bronchiolitis obliterans syndrome.
abstract: BACKGROUND
  Exhaled breath condensate (EBC) analysis is a promising method for investigating airway pathology. In this pilot study we tested the cytokine pattern of EBC of lung transplant patients with and without clinical evidence of bronchiolitis obliterans syndrome (BOS).
  
  
  METHODS
  Breath condensates collected from eight BOS patients and eight stable BOS-free lung transplant recipients in three consecutive visits were pooled in order to increase protein concentration and were then used for antibody microarray analysis detecting 120 cytokines simultaneously.
  
  
  RESULTS
  Nine cytokines exhibited more than twofold increase and four exhibited more than twofold decrease in BOS patients as compared to stable subjects.
  
  
  CONCLUSIONS
  We conclude that inflammatory cytokines are present in EBC of lung transplant recipients, however the potential benefit of detecting the EBC proteome warrants further studies.
authors.affiliation: Department of Pathophysiology, National Koranyi Institute for TB and Pulmonology, Budapest, Hungary. antusb@hotmail.com
authors.forename: Balazs
authors.initials: B
authors.lastname: Antus
authors.forename: Imre
authors.initials: I
authors.lastname: Barta
authors.forename: Krisztina
authors.initials: K
authors.lastname: Czebe
authors.forename: Ildiko
authors.initials: I
authors.lastname: Horvath
authors.forename: Eszter
authors.initials: E
authors.lastname: Csiszer
mesh_terms: D051722:ADAM Proteins / Q000378:metabolism; D000328:Adult; D001944:Breath Tests; D001989:Bronchiolitis Obliterans / Q000378:metabolism* / Q000601:surgery*; D016207:Cytokines / Q000378:metabolism*; D045853:Exhalation; D005260:Female; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000378:metabolism; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism; D018793:Interleukin-13 / Q000378:metabolism; D016040:Lung Transplantation; D008297:Male; D010865:Pilot Projects; D014180:Transplantation; D025521:Tumor Suppressor Proteins / Q000378:metabolism
chemical_list: D016207:Cytokines; D051100:Glial Cell Line-Derived Neurotrophic Factor; D018793:Interleukin-13; D025521:Tumor Suppressor Proteins; D016753:Interleukin-10; D051722:ADAM Proteins; C090222:ADAM11 protein, human