The high mobility group A1 gene: transforming inflammatory signals into cancer?
High mobility group A1 (HMGA1) is highly expressed during embryogenesis and in poorly differentiated cancers, and high levels portend a poor prognosis in some tumors. HMGA1 induces oncogenic transformation in cultured cells and causes aggressive cancers in transgenic mice, whereas blocking it interferes with transformation in experimental models. These findings suggest a pivotal role for HMGA1 in cancer. This review focuses on two recently described HMGA1 transcriptional targets that mediate inflammatory signals and drive malignant transformation because they could serve as biomarkers or therapeutic targets. Further elucidation of HMGA1 function in transformation promises to have a major impact on our war on cancer.
Resar
Linda M S
LM
The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2109., USA. lresar@jhmi.edu
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism; D025741:HMGA1a Protein / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000473:pathology; D051379:Mice; D009369:Neoplasms / Q000235:genetics / Q000473:pathology
D025741:HMGA1a Protein