title: [Effect of general anesthesia used in cesarean section on maternal-neonatal outcome of pregnancy complicated with severe thrombocytopenia].
abstract: OBJECTIVE
  To investigate the effect of general anesthesia on pregnancy women with thrombocytopenia and neonate during cesarean section (CS).
  
  
  METHODS
  Sixty-five singleton pregnant women with low platelet count (< 50 x 10(9)/L) and gestation>35 weeks were allocated into general anesthesia group (35 cases) and local anesthesia group (30 cases) randomly. The time from skin incision to fetal delivery, the oxyhemoglobin saturation (SO2) before and after anesthesia, the blood loss during operation, Apgar scores at 1 min, birth weight,umbilical cord blood gas analysis were recorded.
  
  
  RESULTS
  The mean time from anesthesia induction to fetal delivery was (9.7 +/- 3.5) minutes in general anesthesia group. The time from skin incision to fetal delivery in general anesthesia group [(7.7 +/- 2.5) minutes] was shorter than that in local anesthesia group [(12.5 +/- 3.0) minutes, P < 0.01], while the operation time had no significant differences. There were no significant difference for the value of SO2 before and after general anesthesia or local anesthesia (P > 0.05). There was no significant difference for the blood loss [(471 +/- 245) ml vs. (452 +/- 213) ml, P > 0.05], Apgar scores at 1 minute, birth weight and umbilical cord blood gas analysis between the two groups (P > 0.05). There had two infants with blue asphyxia in local anesthesia group while no infant with asphyxia in general anesthesia group.
  
  
  CONCLUSIONS
  General anesthesia is safe to pregnant women with thrombocytopenia during CS.
authors.affiliation: Department of Obstetrics, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wei
authors.forename: Guo-li
authors.initials: GL
authors.lastname: Liu
authors.forename: Mei-ying
authors.initials: MY
authors.lastname: Liang
authors.forename: Shan-mi
authors.initials: SM
authors.lastname: Wang
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D000773:Anesthesia, Obstetrical / Q000379:methods*; D001034:Apgar Score; D001724:Birth Weight; D001784:Blood Gas Analysis; D002585:Cesarean Section; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011256:Pregnancy Outcome; D013921:Thrombocytopenia / Q000150:complications* / Q000453:epidemiology; D014469:Umbilical Arteries; D014471:Umbilical Veins