title: OXY-SCORE: a global index to improve evaluation of oxidative stress by combining pro- and antioxidant markers.
abstract: Our group recently proposed OXY-SCORE, a summary index of oxidative stress, computed by combining plasma free and total malondialdehyde (F- and T-MDA), glutathione in disulphide/reduced forms (GSSG/GSH), alpha- and gamma-tocopherol (TH), urine isoprostanes (iPF(2alpha)-III) levels, and plasma individual antioxidant capacity. Here, we describe the methods for the determination of the analytes and for the computation of the scores. We also report the results of two studies testing the performances of OXY-SCORE, and showing its value in assessing the oxidative status of cardiovascular patients and healthy subjects.
authors.affiliation: Unit of Biostatistics, Centro Cardiologico Monzino IRCCS, Milano, Italy. fabrizio.veglia@ccfm.it
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Veglia
authors.forename: Viviana
authors.initials: V
authors.lastname: Cavalca
authors.forename: Elena
authors.initials: E
authors.lastname: Tremoli
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D005978:Glutathione / Q000097:blood; D019803:Glutathione Disulfide / Q000097:blood; D006801:Humans; D028421:Isoprostanes / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D028421:Isoprostanes; D014810:Vitamin E; D008315:Malondialdehyde; D005978:Glutathione; D019803:Glutathione Disulfide