title: In-hospital complication rates after stent treatment of 388 symptomatic intracranial stenoses: results from the INTRASTENT multicentric registry.
abstract: OBJECTIVE
  Stenting is increasingly used as an adjunct to medical therapy in symptomatic intracranial stenoses. High periprocedural adverse event rates are one of the limitations of endovascular treatment. Data from the INTRASTENT multicentric registry should demonstrate in-hospital complications at the current stage of clinical development of the stent procedure.
  
  
  METHODS
  Participating centers entered the records of all their consecutive intracranial stent procedures into the database. To determine the clinical outcome in the acute phase, we distinguished transient ischemic attack/nondisabling stroke (modified Rankin Scale <2), disabling stroke, death, and intracranial hemorrhage as clinical complications and analyzed whether they were associated with patient- or stenosis-related risk factors.
  
  
  RESULTS
  Data from 372 patients with 388 stenoses proved 4.8% disabling strokes and 2.2% deaths. Transient or minor events were detected in 5.4% of the cases. Hemorrhagic events (3.5%) occurred more frequently after treatment of middle cerebral artery stenoses (P=0.004) and were associated with significantly higher morbidity and mortality rates. Ischemic strokes by compromise of perforating branches were detected mainly in the posterior circulation. However, the overall rate of severe adverse events was not dependent from location, degree, and morphology of the stenosis or from patient's age, gender, vascular risk factors, or type of qualifying event.
  
  
  CONCLUSIONS
  The complication rates within the registry are within the limits of previously published data. Severe adverse events were equally distributed between potential risk groups with similar rates but different types of main complications in the anterior and posterior circulation.
authors.affiliation: Department of Neuroradiology, University of Frankfurt, Schleusenweg 2-16, 60528 Frankfurt, Germany. wiebke.kurre@kgu.de
authors.forename: Wiebke
authors.initials: W
authors.lastname: Kurre
authors.forename: Joachim
authors.initials: J
authors.lastname: Berkefeld
authors.forename: Friedhelm
authors.initials: F
authors.lastname: Brassel
authors.forename: Roland
authors.initials: R
authors.lastname: Brüning
authors.forename: Bernd
authors.initials: B
authors.lastname: Eckert
authors.forename: Seniye
authors.initials: S
authors.lastname: Kamek
authors.forename: Guenther E
authors.initials: GE
authors.lastname: Klein
authors.forename: Michael
authors.initials: M
authors.lastname: Knauth
authors.forename: Thomas
authors.initials: T
authors.lastname: Liebig
authors.forename: Jana
authors.initials: J
authors.lastname: Maskova
authors.forename: Dirk
authors.initials: D
authors.lastname: Mucha
authors.forename: Tobias
authors.initials: T
authors.lastname: Neumann-Haefelin
authors.forename: Sara
authors.initials: S
authors.lastname: Pilgram-Pastor
authors.forename: Matthias
authors.initials: M
authors.lastname: Sitzer
authors.forename: Michael
authors.initials: M
authors.lastname: Sonnberger
authors.forename: Mark
authors.initials: M
authors.lastname: Tietke
authors.forename: Johannes
authors.initials: J
authors.lastname: Trenkler
authors.forename: Bernd
authors.initials: B
authors.lastname: Turowski
mesh_terms: D000368:Aged; D017130:Angioplasty / Q000009:adverse effects* / Q000295:instrumentation / Q000639:trends; D003251:Constriction, Pathologic / Q000150:complications / Q000401:mortality / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization / Q000639:trends*; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality; D011446:Prospective Studies; D012042:Registries; D012189:Retrospective Studies; D015607:Stents / Q000009:adverse effects*; D016896:Treatment Outcome