title: Titanate-silica mesostructured nanocables: synthesis, structural analysis and biomedical applications.
abstract: 1D hierarchical composite mesostructures of titanate and silica were synthesized via an interfacial surfactant templating approach. Such mesostructures have complex core-shell architectures consisting of single-crystalline H(2)Ti(3)O(7) nanobelts inside the ordered mesoporous SiO(2) shell, which are nontoxic and highly biocompatible. The overall diameter of as-prepared 1D hierarchical composite mesostructures is only approx. 34.2 nm with a length over 500 nm on average. A model to explain the formation mechanism of these mesostructures has been proposed; the negatively charged surface of H(2)Ti(3)O(7) nanobelts controls the formation of the octadecyltrimethylammonium bromide (C(18)TAB) bilayer, which in turn regulates the cooperative self-assembly of silica and C(18)TAB complex micelles on the interface to produce a mesoporous silica shell. More importantly, the application of synthesized mesostructured nanocables as anticancer drug reservoirs has also been explored, which indicates that the membranes containing these mesoporous nanocables have a great potential to be used as transdermal drug delivery systems.
authors.affiliation: Department of Traditional Chinese Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Su
authors.forename: Shizhang
authors.initials: S
authors.lastname: Qiao
authors.forename: Huagui
authors.initials: H
authors.lastname: Yang
authors.forename: Chen
authors.initials: C
authors.lastname: Yang
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Jin
authors.forename: Frances
authors.initials: F
authors.lastname: Stahr
authors.forename: Jiayu
authors.initials: J
authors.lastname: Sheng
authors.forename: Lina
authors.initials: L
authors.lastname: Cheng
authors.forename: Changquan
authors.initials: C
authors.lastname: Ling
authors.forename: Gao Qing
authors.initials: GQ
authors.lastname: Lu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002018:Bufanolides / Q000008:administration & dosage*; D003692:Delayed-Action Preparations / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D012822:Silicon Dioxide / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry; D014025:Titanium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D002018:Bufanolides; D003692:Delayed-Action Preparations; D013501:Surface-Active Agents; D012822:Silicon Dioxide; D014025:Titanium; C022777:bufalin