Helicobacter pylori antibiotic resistance and [13C]urea breath test values.
A correlation between delta over baseline (DOB) values of the [(13)C]urea breath test (UBT) and Helicobacter pylori clarithromycin resistance has been reported, suggesting a possible predictive role of UBT in therapeutic outcome. However, available data are limited and conflicting. This study aimed to clarify this issue, assessing the possible relationship between H. pylori resistance towards different antibiotics (clarithromycin, metronidazole and levofloxacin) and UBT values. The data showed similar DOB values between susceptible and resistant strains for clarithromycin (46.9+/-32.3 vs 45.7+/-30.6; P=0.8), metronidazole (46.4+/-29.6 vs 47.4+/-37.9; P=0.8), and levofloxacin (45.0+/-30.2 vs 54.2+/-38.4; P=0.08). Likewise, comparable DOB values were observed between susceptible and multidrug-resistant strains (45.4+/-29.6 vs 54.8+/-44.8; P=0.1). In conclusion, our data failed to find a significant correlation between UBT values and H. pylori antibiotic resistance.
De Francesco
Vincenzo
V
Section of Gastroenterology, Department of Medical Sciences, University of Foggia, Foggia, Italy.
Zullo
Angelo
A
Gastroenterology and Digestive Endoscopy, 'Nuovo Regina Margherita' Hospital, Rome, Italy.
Perna
Federico
F
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy.
Giorgio
Floriana
F
Section of Gastroenterology, Department of Medical Sciences, University of Foggia, Foggia, Italy.
Hassan
Cesare
C
Gastroenterology and Digestive Endoscopy, 'Nuovo Regina Margherita' Hospital, Rome, Italy.
Vannella
Lucy
L
Section of Gastroenterology, Department of Medical Sciences, University of Foggia, Foggia, Italy.
Cristofari
Francesca
F
Gastroenterology and Digestive Endoscopy, 'Nuovo Regina Margherita' Hospital, Rome, Italy.
Panella
Carmine
C
Section of Gastroenterology, Department of Medical Sciences, University of Foggia, Foggia, Italy.
Vaira
Dino
D
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy.
Ierardi
Enzo
E
Section of Gastroenterology, Department of Medical Sciences, University of Foggia, Foggia, Italy.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000032:analysis*; D001944:Breath Tests; D017291:Clarithromycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005260:Female; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification*; D006801:Humans; D064704:Levofloxacin; D008297:Male; D008795:Metronidazole / Q000494:pharmacology; D008875:Middle Aged; D015242:Ofloxacin / Q000494:pharmacology; D013223:Statistics as Topic; D014508:Urea / Q000378:metabolism; D014510:Urease / Q000032:analysis
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D008795:Metronidazole; D064704:Levofloxacin; D014508:Urea; D015242:Ofloxacin; D014510:Urease; D017291:Clarithromycin