title: Repeated cocaine administration increases cleaved poly(ADP-ribose) polymerase-1 expression in the rat dorsal striatum.
abstract: Poly(ADP-ribose) polymerase-1 (PARP-1) expression is associated with the endoplasmic reticulum (ER) stress response in neurons. In this study, the regulation of PARP-1 activation by repeated cocaine administration in the rat dorsal striatum was investigated in vivo. Our results demonstrated that repeated systemic injections of cocaine (20 mg/kg) once a day for 7 days increased cleaved PARP-1 expression. This increase was reduced by blocking dopamine D1, but not dopamine D2, receptors. The blocking of group I metabotropic glutamate receptors (mGluRs), mGluR1 subtype, and N-methyl-D-aspartate receptors also reduced cocaine-stimulated cleaved PARP-1 expression. Taken together, these findings suggest that PARP-1 activation is upregulated by repeated cocaine administration, and that interactions between dopamine D1 and glutamate receptors may be involved in this upregulation.
authors.affiliation: Department of Biological Sciences, Pusan National University, 30 Jangjeon-dong, Kumjeong-gu, Biology Bldg., Room 311, Pusan 609-735, Republic of Korea.
authors.forename: Ju Hwan
authors.initials: JH
authors.lastname: Yang
authors.forename: Eun Sang
authors.initials: ES
authors.lastname: Choe
mesh_terms: D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000201:enzymology; D004789:Enzyme Activation; D008297:Male; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000502:physiology; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology
chemical_list: D000697:Central Nervous System Stimulants; D017447:Receptors, Dopamine D1; D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; C104077:metabotropic glutamate receptor type 1; C499321:Parp1 protein, mouse; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases; D003042:Cocaine