title: A real-time, telemetric method for continuous measurement of portal pressures.
abstract: The ability to longitudinally monitor portal and splanchnic pressures would greatly enhance the understanding of acute and chronic liver disease by helping to assess the immediate and long-term impact of therapeutic manipulations. However, a technique for measuring portal pressures in the ambulatory setting is not currently available. To overcome this difficulty, we utilized an approach that involved the implantation of a miniature telemetric device, equipped with a specially-designed pressure transmission catheter, into the spleen of an anesthetized mouse. Using this approach, portal pressures were measured continuously over 5 d in conscious, unrestrained animals, the availability of which will help facilitate studies of the portal circulation requiring long-term stability.
authors.affiliation: Department of Surgery, University of Utah, Salt Lake City, Utah 84132, USA. jason.schwartz@hsc.utah.edu
authors.forename: Jason
authors.initials: J
authors.lastname: Schwartz
authors.forename: Andreas
authors.initials: A
authors.lastname: Rohrwasser
authors.forename: Elaine
authors.initials: E
authors.lastname: Hillas
authors.forename: Jenny
authors.initials: J
authors.lastname: Hatch
authors.forename: John
authors.initials: J
authors.lastname: Sorensen
authors.forename: Timothy
authors.initials: T
authors.lastname: Gayowski
authors.forename: William
authors.initials: W
authors.lastname: Hutson
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Lalouel
mesh_terms: D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D015918:Infusion Pumps, Implantable; D008107:Liver Diseases / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017082:Portal Pressure / Q000502:physiology*; D013152:Splanchnic Circulation / Q000502:physiology*; D013686:Telemetry / Q000295:instrumentation / Q000379:methods