title: A new kalihinol diterpene from the Hainan sponge Acanthella sp.
abstract: A new kalihinol diterpene, 10-epi-kalihinol X (1), together with two known related diterpenes (2 and 3), and two sesquiterpenes (4 and 5) were isolated from the Hainan sponge Acanthella sp. The structure of the new compound was elucidated on the basis of the detailed analysis of its spectroscopic data and by comparison of its NMR data with those of structurally related compounds. Compounds 1 and 3-5 exhibited in vitro moderate cytotoxicities against human lung adenocarcinoma cell line A549, with IC50 values of 9.30, 3.17, 2.44, and 1.98 microg/mL, respectively.
authors.affiliation: College of Life Science, Shandong University, Jinan, China.
authors.forename: Ji-Zheng
authors.initials: JZ
authors.lastname: Sun
authors.forename: Kao-Shan
authors.initials: KS
authors.lastname: Chen
authors.forename: Li-Gong
authors.initials: LG
authors.lastname: Yao
authors.forename: Hai-Li
authors.initials: HL
authors.lastname: Liu
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C547410:10-epi-kalihinol X; D000970:Antineoplastic Agents; D004224:Diterpenes; D012717:Sesquiterpenes