title: Trp64Arg polymorphism in beta3-adrenergic receptor gene is associated with decreased fat oxidation both in resting and aerobic exercise in the Japanese male.
abstract: The purpose of our study was to investigate whether the Trp64Arg polymorphism in beta3-AR gene and the -3826A/G polymorphism in the UCP1 gene were associated with the reduction in energy expenditure and fat oxidation both in resting and aerobic exercise in Japanese. Eighty-six nonobese young healthy Japanese were recruited. Energy expenditure was measured using indirect calorimetry. The subjects performed an aerobic exercise program at 60% of their maximal heart rate for 30 minutes. The level of fat oxidation at rest and aerobic exercise of the male subjects with Trp/Arg of the beta3-AR gene was significantly lower than that of the Trp/Trp genotype. No difference in FO(0-30) was observed in the female subjects. There was no association between UCP-1 polymorphism and energy expenditure during aerobic exercise. It was revealed that the Trp64Arg polymorphism in beta3-AR gene is associated with reduction of fat oxidation both in resting and aerobic exercise in healthy, young Japanese males.
authors.affiliation: Graduate School of Human Science and Environment, University of Hyogo, 1-1-12 Shinzaike-Honmachi, Himeji, Hyogo 670-0092, Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Morita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Motoyoshi
authors.initials: M
authors.lastname: Sakaue
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution; D001120:Arginine / Q000235:genetics; D044466:Asian People / Q000235:genetics; D001794:Blood Pressure; D002153:Calorimetry, Indirect; D004041:Dietary Fats / Q000378:metabolism*; D002149:Energy Intake; D015444:Exercise / Q000502:physiology*; D005260:Female; D005838:Genotype; D006339:Heart Rate; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D008297:Male; D024101:Mitochondrial Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D012146:Rest / Q000502:physiology; D014364:Tryptophan / Q000235:genetics; D000071256:Uncoupling Protein 1; D055815:Young Adult
chemical_list: D004041:Dietary Fats; D007473:Ion Channels; D024101:Mitochondrial Proteins; D022702:Receptors, Adrenergic, beta-3; C000604371:UCP1 protein, human; D000071256:Uncoupling Protein 1; D014364:Tryptophan; D001120:Arginine