title: Efficacy of a low-concentration chlorhexidine mouth rinse in non-compliant periodontitis patients attending a supportive periodontal care programme: a randomized clinical trial.
abstract: OBJECTIVE
  To assess the clinical and microbiological efficacy of a 0.05% chlorhexidine and 0.05% cetyl-pyridinium chloride mouth rinse in supportive periodontal care (SPC) in patients with inadequate plaque control.
  
  
  METHODS
  The study was a randomized, double-blinded, placebo-controlled clinical trial in patients with moderate to severe chronic periodontitis under SPC with an inadequate plaque control (Turesky index >1). After supragingival prophylaxis and oral hygiene reinforcement, participants rinsed twice a day for 3 months with the test or placebo solutions, in addition to conventional hygiene. Primary clinical outcome variables included plaque and gingival indices. As secondary outcomes, periodontal and microbiological variables were studied. ancova and chi(2) tests were used to compare the variables.
  
  
  RESULTS
  Forty-seven patients (22 placebo and 25 test group) participated. After 3 months, plaque levels increased in the placebo group, while diminished in the test group (p<0.001). Similar effects were found for bleeding on probing. The other clinical parameters did not show significant differences. Microbiological variables demonstrated inter-group significant reductions in subgingival counts of Fusobacterium nucleatum and Prevotella intermedia and a decrease of the total bacterial counts in saliva.
  
  
  CONCLUSIONS
  The tested mouth rinse demonstrated efficacy in reducing plaque and gingivitis, as well as in decreasing the microbial load in saliva and gingival sulcus.
authors.affiliation: Section of Graduate Periodontology, Faculty of Odontology, Complutense University, Madrid, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Escribano
authors.forename: David
authors.initials: D
authors.lastname: Herrera
authors.forename: Sergio
authors.initials: S
authors.lastname: Morante
authors.forename: Wim
authors.initials: W
authors.lastname: Teughels
authors.forename: Marc
authors.initials: M
authors.lastname: Quirynen
authors.forename: Mariano
authors.initials: M
authors.lastname: Sanz
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002594:Cetylpyridinium / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D002710:Chlorhexidine / Q000627:therapeutic use*; D055113:Chronic Periodontitis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D003773:Dental Plaque / Q000150:complications / Q000188:drug therapy / Q000382:microbiology; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D016967:Fusobacterium nucleatum / Q000187:drug effects; D005891:Gingivitis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D009910:Oral Hygiene; D010349:Patient Compliance; D010512:Periodontal Index; D018713:Prevotella intermedia / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D002594:Cetylpyridinium; D002710:Chlorhexidine