title: Primary pituitary lymphoma: idiopathic anasarca with relapse in bone marrow only.
abstract: We report a case of primary large B cell-type pituitary lymphoma in a 47-year-old immunocompetent female who presented with headache and cranial nerve palsy. She was treated with the DeAngelis chemotherapy protocol and achieved a complete remission. At 1 and 6 months after completion of chemotherapy, she presented with anasarca and was diagnosed with relapse exclusively in the bone marrow twice. She received 8 cycles of R-CHOP chemotherapy and had complete resolution of anasarca. Consequently, we proceeded with salvage chemotherapy followed by autologous stem cell transplantation. To our knowledge, this is the first reported case of primary pituitary lymphoma that relapsed exclusively in the bone marrow and presented with clinical findings of idiopathic anasarca.
authors.affiliation: Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA. sbayraktar@med.miami.edu
authors.forename: Soley
authors.initials: S
authors.lastname: Bayraktar
authors.forename: Wilfredo
authors.initials: W
authors.lastname: Bassini
authors.forename: Mark
authors.initials: M
authors.lastname: Goodman
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001855:Bone Marrow Diseases / Q000209:etiology*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004487:Edema / Q000209:etiology*; D005260:Female; D006801:Humans; D045022:Lactate Dehydrogenases / Q000097:blood; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications* / Q000188:drug therapy; D011241:Prednisone / Q000008:administration & dosage; D012008:Recurrence; D016879:Salvage Therapy; D033581:Stem Cell Transplantation; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D045022:Lactate Dehydrogenases; D011241:Prednisone