title: Peptide-based activity-based probes (ABPs) for target-specific profiling of protein tyrosine phosphatases (PTPs).
abstract: Synthesis of a novel unnatural amino acid (2-FMPT) for the solid-phase synthesis of peptide-based probes suitable for target-specific activity-based profiling of protein tyrosine phosphatases from crude proteomes is reported.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors.forename: Karunakaran A
authors.initials: KA
authors.lastname: Kalesh
authors.forename: Lay Pheng
authors.initials: LP
authors.lastname: Tan
authors.forename: Kai
authors.initials: K
authors.lastname: Lu
authors.forename: Liqian
authors.initials: L
authors.lastname: Gao
authors.forename: Jigang
authors.initials: J
authors.lastname: Wang
authors.forename: Shao Q
authors.initials: SQ
authors.lastname: Yao
mesh_terms: D000818:Animals; D002460:Cell Line; D006801:Humans; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D019000:Phosphotyrosine / Q000031:analogs & derivatives*; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D020543:Proteome / Q000378:metabolism; D040901:Proteomics; D013379:Substrate Specificity
chemical_list: D010455:Peptides; D020543:Proteome; D019000:Phosphotyrosine; D017027:Protein Tyrosine Phosphatases