Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene/ruthenium organometallic species.
Two ethylene linked binuclear mixed ferrocene/ruthenium complexes were biologically investigated in comparison to structurally related mononuclear ferrocene or ruthenium species with styryl substituents or ligands. Results indicated that the electron distribution (but not the redox potential), cellular uptake and (to some minor extent) anti-estrogenic effects were the key contributors to antiproliferative effects observed in tumor cell lines.
Ott
Ingo
I
Institute of Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106 Braunschweig, Germany. ingo.ott@tu-bs.de
Kowalski
Konrad
K
Gust
Ronald
R
Maurer
Jörg
J
Mücke
Philipp
P
Winter
Rainer F
RF
D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005030:Ethylenes / Q000737:chemistry* / Q000494:pharmacology; D005296:Ferrous Compounds / Q000737:chemistry* / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D000075163:Metallocenes; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry* / Q000494:pharmacology
D005030:Ethylenes; D005296:Ferrous Compounds; D000075163:Metallocenes; D009942:Organometallic Compounds; D012428:Ruthenium; C004998:ferrocene