Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators.
In this review we discuss both gene expression and protein localization changes of polarity proteins in carcinoma. We highlight the importance of protein mislocalization and its possible role in cancer. We also discuss the emerging role of polarity proteins as regulators of proliferation, apoptosis, tissue polarity, epithelial-mesenchymal transition, in addition to their known role in cell junction biogenesis.
Huang
Ling
L
Ontario Cancer Institute, Campbell Family Institute for Breast Cancer Research, Dept. of Medical Biophysics, University of Toronto, Toronto, Canada.
Muthuswamy
Senthil K
SK
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D017209:Apoptosis; D002277:Carcinoma / Q000235:genetics* / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism; D002465:Cell Movement; D016764:Cell Polarity / Q000235:genetics*; D049109:Cell Proliferation; D005136:Eye Proteins / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009703:Nucleoside-Phosphate Kinase / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; C448939:CRB1 protein, human; D018797:Cell Cycle Proteins; D005136:Eye Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C509689:PARD3 protein, human; D009703:Nucleoside-Phosphate Kinase; C501307:MPP5 protein, human