Obesity alters retrieved oocyte count and clinical pregnancy rates in high and poor responder women after in vitro fertilization.
OBJECTIVE
Ovarian responsiveness to ovulation induction agents is essential for a successful clinical outcome in assisted reproductive technology (ART) cycles. We aimed to evaluate the accuracy of multinominal logistic models for the prediction of ovarian reserve and pregnancy in women undergoing ART cycles.


METHODS
1,970 patients who underwent ovarian stimulation for ART programs were evaluated. Patients were designated to ovarian response with body mass index (BMI) and age.


RESULTS
When evaluating the factors affecting the egg quantity in poor responder and high responder patient groups according to the BMI, we observed that there was a lower probability of extracting less than five eggs in patients with a BMI of over 30 kg/m(2). The BMI was not an influential parameter for the amount of eggs obtained when comparing norm responder and high responder patient groups. Otherwise, obesity does not constitute a risk factor for positive pregnancy. Being 36-40 years of age is an important risk factor in foreseeing pregnancy.


CONCLUSIONS
Predicting and managing the variability between patients is a significant clinical challenge in stimulation protocols. Research into predictive factors and the construction of multivariate models are the first steps towards evidence-based individualized treatment. The current practice of individualized treatment is based only on clinical experience and has poor reproducibility.
Kilic
Sevtap
S
Department of Reproductive Endocrinology and ART, Dr. Zekai Tahir Burak Women Health Educational and Resarch Hospital, Ankara, Turkey.
Yilmaz
Nafiye
N
Zülfikaroglu
Ebru
E
Sarikaya
Esma
E
Kose
Kenan
K
Topcu
Onur
O
Batioglu
Sertac
S
D000328:Adult; D017677:Age Distribution; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D016015:Logistic Models; D009765:Obesity / Q000150:complications*; D009865:Oocytes; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult