title: [A case of type 4 advanced gastric cancer treated by S-1 simple suspension method with CDDP].
abstract: S-1 is a key drug for advanced, recurrent gastric cancer. It is difficult to administer S-1 for inoperable gastric cancer with stenosis. We report that a simple suspension method allows administration of S-1 for improved quality of life. The patient was a 65-year-old woman. She consulted a doctor regarding her poor food intake, and had a medical examination with chest-abdominal CT and gastrofiberscopy. She was diagnosed as type 4 gastric cancer with esophageal invasion. It was difficult for her to drink a cup of water due to the stenosis, but we could insert a 6 Fr-Elemental Diet (ED) tube into her stomach. S-1 was dissolved by the simple suspension method. She received combination chemotherapy of S-1 100mg/body (day 1-21) and CDDP 80 mg/body (day 8). After two courses, her intake was much improved; she was able to eat rice porridge and was discharged with improved quality of life. S-1 suspension with ED tube was effective for advanced gastric cancer with stenosis.
authors.affiliation: Department of Digestive Tract Surgery, Tokyo Medical University Hachioji Medical Center, Japan.
authors.forename: Kazushige
authors.initials: K
authors.lastname: Ito
authors.forename: Takashi
authors.initials: T
authors.lastname: Ogata
authors.forename: So
authors.initials: S
authors.lastname: Katayanagi
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Nomura
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ishizaki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yasuda
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sonoda
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Sumi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Tsuchida
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Aoki
authors.forename: Motohide
authors.initials: M
authors.lastname: Shimazu
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage*; D003251:Constriction, Pathologic; D004338:Drug Combinations; D005260:Female; D006801:Humans; D010094:Oxonic Acid / Q000008:administration & dosage*; D011788:Quality of Life; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013535:Suspensions; D005641:Tegafur / Q000008:administration & dosage*
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D004338:Drug Combinations; D013535:Suspensions; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin