title: [Anaphylactic shock due to patent blue: four case report and review of literature].
abstract: OBJECTIVE
  Description of four cases of anaphylactic shock with blue dye injection (bleu patenté V Guerbet 2.5%) during sentinel node biopsy for breast cancer.
  
  
  METHODS
  Women with breast carcinoma and combined approach with radioactive tracer and blue patent injection.
  
  
  RESULTS
  Four cases were observed, which means an incidence of 0.57%. We report one case of grade II anaphylactic reaction and three cases of grade III requiring active reanimation and adrenaline perfusion. One patient developed a pulmonary embolism during the postoperative period, but no death was observed.
  
  
  CONCLUSIONS
  We find an incidence of 1.06% of allergy but only 0.25% of anaphylactic shock (grade III). These rare but serious cases must weigh up the benefits and risks of using blue dye. We suggest using blue dye injection only in case of radioisotope detection failure. Of course, this approach must be evaluated.
authors.affiliation: Service de chirurgie oncologique, centre Paul-Papin, Angers, France.
authors.forename: N
authors.initials: N
authors.lastname: Lucas
authors.forename: S Benay
authors.initials: SB
authors.lastname: Interne
authors.forename: P
authors.initials: P
authors.lastname: Laine
authors.forename: B
authors.initials: B
authors.lastname: Nicolie
authors.forename: E
authors.initials: E
authors.lastname: Fondrinier
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced* / Q000453:epidemiology; D001943:Breast Neoplasms / Q000473:pathology; D004396:Coloring Agents; D005260:Female; D006801:Humans; D008875:Middle Aged; D012394:Rosaniline Dyes / Q000276:immunology*; D021701:Sentinel Lymph Node Biopsy
chemical_list: D004396:Coloring Agents; D012394:Rosaniline Dyes; C008769:sulfan blue