Inhibitory effect of proanthocyanidin on ultraviolet B irradiation-induced melanogenesis.
Repetitive exposure of the skin to ultraviolet (UV) radiation induces various adverse effects, including skin thickening, wrinkle formation, inflammation, and pigmentation. Various natural and synthetic compounds were studied to determine whether they might prevent UV induction of these adverse effects. In particular, naturally occurring antioxidants were used for regulating skin damage induced by UV radiation since several antioxidants were found to inhibit photoaging through prevention of collagen synthesis via inhibition of matrix metalloproteinases (MMP) and/or decrease of melanin synthesis. The L values in pigmented skin were lower at 4 wk (52.97 +/- 2.09) than at the start of this study (0 wk, 62.89 +/- 0.56) in the control. In the proanthocyanidin mixture group, the L value was increased (56.83 +/- 1.71) similar to the control (52.97 +/- 2.09). Proanthocyanidin also suppressed the expression levels of tyrosinase by 20-40%, and blocked the expression of MITF, TRP-1, and TRP-2, which are factors implicated in the control of melanogenesis. Taken together, these data indicate that proanthocyanidin may be useful to attenuate UVB-induced melanogenesis.
Cho
Ho-Song
HS
College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Republic of Korea.
Kwak
Dong Hoon
DH
Choi
Im Seup
IS
Park
Hyung Kook
HK
Kang
Sang Jin
SJ
Yoo
Hwan Soo
HS
Lee
Moon Soon
MS
Oh
Ki-Won
KW
Hong
Jin Tae
JT
D000363:Agaricales / Q000201:enzymology; D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008543:Melanins / Q000378:metabolism*; D008545:Melanoma; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D010858:Pigmentation / Q000187:drug effects* / Q000528:radiation effects; D044945:Proanthocyanidins / Q000494:pharmacology*; D014466:Ultraviolet Rays
D008543:Melanins; D044945:Proanthocyanidins; C013221:proanthocyanidin; D014442:Monophenol Monooxygenase