title: Clonal complex chromosome aberration in non-ossifying fibroma.
abstract: Cytogenetic information of non-ossifying fibromas (NOFs) is exceptionally limited. This fact relies, in part, on their benign nature but mainly because most cases evolve undetected or there is no need for surgical intervention. We report the case of a NOF arising in the left tibia of a 14-year-old male with an invariable clonal translocation. The karyotype was denoted as 42-46,XY,t(11;3;14)(q23;p21;p11). There are only two previous reported cases of clonally aberrant NOF. Records from additional cases will be essential to assess whether consistent karyotypic aberrations define this lesion.
authors.affiliation: Department of Pediatrics, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil. marsol@rge.fmrp.usp.br
authors.forename: María Sol
authors.initials: MS
authors.lastname: Brassesco
authors.forename: Elvis Terci
authors.initials: ET
authors.lastname: Valera
authors.forename: Edgard Eduard
authors.initials: EE
authors.lastname: Engel
authors.forename: Marcello Henrique
authors.initials: MH
authors.lastname: Nogueira-Barbosa
authors.forename: Aline Paixão
authors.initials: AP
authors.lastname: Becker
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Scrideli
authors.forename: Luiz Gonzaga
authors.initials: LG
authors.lastname: Tone
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000235:genetics* / Q000473:pathology; D020732:Cytogenetic Analysis; D005350:Fibroma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D013977:Tibia; D014178:Translocation, Genetic