Rhabdomyolysis associated with olanzapine treatment in a child with Autism.
Children with autism often display difficult behaviors including tantrums, extreme irritability, and physical aggression. There is emerging evidence that olanzapine is useful in decreasing these disruptive behaviors. The most common adverse effects are weight gain and short-term sedation. On the other hand, olanzapine rarely causes rhabdomyolysis. We report a case with rhabdomyolysis in an autistic child just after 2 doses of olanzapine treatment. Initial creatine kinase value was 30,690 IU/L (range, 5-130 U/L), and rhabdomyolysis resolved with hydration and alkalinization over 7 days. Monitoring serum creatine kinase levels may be useful in pediatric cases after initiation of olanzapine treatment.
Karakaya
Pakize
P
Department of Pediatric, School of Medicine, Dokuz Eylül University, Izmir, Turkey. pakizekarakaya@gmail.com
Yiş
Uluç
U
Kurul
Semra Hz
SH
Türkmen
Mehmet Atilla
MA
D000293:Adolescent; D001321:Autistic Disorder / Q000188:drug therapy*; D001569:Benzodiazepines / Q000009:adverse effects* / Q000627:therapeutic use; D003402:Creatine Kinase / Q000097:blood; D005440:Fluid Therapy / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D000077152:Olanzapine; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000201:enzymology / Q000628:therapy; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
D001569:Benzodiazepines; D003402:Creatine Kinase; D000077152:Olanzapine; D017367:Selective Serotonin Reuptake Inhibitors