ABCC2/Abcc2: a multispecific transporter with dominant excretory functions.
ABCC2/Abcc2 (MRP2/Mrp2) is expressed at major physiological barriers, such as the canalicular membrane of liver cells, kidney proximal tubule epithelial cells, enterocytes of the small and large intestine, and syncytiotrophoblast of the placenta. ABCC2/Abcc2 always localizes in the apical membranes. Although ABCC2/Abcc2 transports a variety of amphiphilic anions that belong to different classes of molecules, such as endogenous compounds (e.g., bilirubin-glucuronides), drugs, toxic chemicals, nutraceuticals, and their conjugates, it displays a preference for phase II conjugates. Phenotypically, the most obvious consequence of mutations in ABCC2 that lead to Dubin-Johnson syndrome is conjugate hyperbilirubinemia. ABCC2/Abcc2 harbors multiple binding sites and displays complex transport kinetics.
Jemnitz
Katalin
K
Chemical Research Center, Institute of Biomolecular Chemistry, HAS, Budapest, Hungary.
Heredi-Szabo
Krisztina
K
Janossy
Judit
J
Ioja
Eniko
E
Vereczkey
Laszlo
L
Krajcsi
Peter
P
D000818:Animals; D001693:Biological Transport, Active; D003001:Cloning, Molecular; D018432:Drug Resistance, Multiple; D006801:Humans; D007700:Kinetics; D051379:Mice; D018345:Mice, Knockout; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011487:Protein Conformation; D015262:Xenobiotics / Q000378:metabolism
D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D015262:Xenobiotics; C000715087:ABCC2 protein, human