title: Expressions of some vital molecules: glioblastoma multiforme versus normal tissues.
abstract: OBJECTIVE
  The aim of this study was to assess plasma and/or tissue levels of adhesion and apoptotic molecules, cytokines, nitric oxide metabolites, levels of lipid peroxidation, myeloperoxidase and superoxide dismutase in patients with glioblastoma multiforme and controls.
  
  
  METHODS
  All the molecules were evaluated in 25 tumors and 30 controls: 15 were normal healthy subjects for plasma and 15 were normal brain tissues that were collected during autopsy. Commercially available kits for measurements were used.
  
  
  RESULTS
  Superoxide dismutase was significantly lower in tumors, while all other molecules were significantly elevated compared to the controls (p=0.0001). Superoxide dismutase negatively correlated with plasma interleukin-1beta (p=0.04) and plasma Fas (p=0.016). Plasma intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 correlated positively with plasma 3-nitrotyrosine (p=0.019) and nitrite/nitrate (p=0.019), respectively. Furthermore, plasma interleukin-1beta also positively correlated with plasma nitrite/nitrate (p=0.003).
  
  
  CONCLUSIONS
  These results suggest that there is a complex relationship between pro- and anti-apoptotic molecules in glioblastoma multiforme pathogenesis. Thus, targeting multiple pathways with advanced chemotherapeutic agents or radiotheraupetic regimens following total resections might be helpful in patients with glioblastoma multiforme since preventing a single pathway does not seem to be reasonable.
authors.affiliation: Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Atukeren
authors.forename: Rahsan
authors.initials: R
authors.lastname: Kemerdere
authors.forename: Tibet
authors.initials: T
authors.lastname: Kacira
authors.forename: Hakan
authors.initials: H
authors.lastname: Hanimoglu
authors.forename: Fatma
authors.initials: F
authors.lastname: Ozlen
authors.forename: Berna
authors.initials: B
authors.lastname: Yavuz
authors.forename: Taner
authors.initials: T
authors.lastname: Tanriverdi
authors.forename: Koray
authors.initials: K
authors.lastname: Gumustas
authors.forename: Bulent
authors.initials: B
authors.lastname: Canbaz
mesh_terms: D000328:Adult; D000368:Aged; D001774:Blood Chemical Analysis; D001921:Brain / Q000378:metabolism*; D001932:Brain Neoplasms / Q000097:blood* / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005909:Glioblastoma / Q000097:blood* / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult