Is the action spectrum for the UV-induced production of previtamin D3 in human skin correct?
The universally recognised action spectrum for the UV-induced conversion of 7-dehydrocholesterol to previtamin D(3) in human skin was published in 1982, and indicates a maximum at about 297 nm with essentially no production above 315 nm. This work represents a milestone in research on vitamin D, but limitations in the original data should be recognised. Various findings have arisen in recent years which cast doubts on the accuracy of the action spectrum and its application for spectral weighting in calculations of effective UV doses. In conclusion, the construction of an entirely new computational model to predict previtamin D levels is recommended.
Norval
Mary
M
Biomedical Sciences, University of Edinburgh Medical School, Teviot Place, Edinburgh, EH8 9AG, UK. M.Norval@ed.ac.uk
Björn
Lars Olof
LO
de Gruijl
Frank R
FR
D002762:Cholecalciferol / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000378:metabolism; D003684:Dehydrocholesterols / Q000378:metabolism; D006801:Humans; D012867:Skin / Q000378:metabolism* / Q000528:radiation effects*; D014466:Ultraviolet Rays
D003684:Dehydrocholesterols; D002762:Cholecalciferol; C016705:7-dehydrocholesterol; C025168:previtamin D(3)