Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression.
Experimental data suggest that the endogenous cannabinoid system is involved in mood regulation, but no study has been performed so far to investigate the role of endocannabinoid genes in the susceptibility to major depression (MD) and/or bipolar disorder (BD). We assessed the CB1 receptor gene (CNR1) single nucleotide polymorphism (SNP) rs1049353 (1359 G/A) and the fatty acid amide hydrolase (FAAH) gene rs324420 SNP (cDNA 385C to A) for their associations with MD and/or BD in 83 Caucasian patients with recurrent MD, 134 Caucasian individuals with BD, and 117 Caucasian healthy subjects. The distribution of the CNR1 1359 G/A genotypes and alleles significantly differed among the groups (chi(2)=12.595; df=4, P=0.01 for genotypes; chi(2)=13.773; df=2, P=0.001 for alleles) with MD patients showing a higher frequency of both AG, GG genotypes and A allele as compared to healthy controls. The distribution of the FAAH cDNA 385C to A genotypes, according to the CC dominant model (AA+AC vs. CC), significantly differed among the groups (chi(2)=6.626; df=2, P=0.04), with both BD patients and MD patients showing a non-significant slightly higher frequency of the AC genotype. These findings, although preliminary, suggest that the CNR1 1359 G/A and the FAAH cDNA 385C to A gene variants may contribute to the susceptibility to mood disorders.
Monteleone
Palmiero
P
Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy. monteri@tin.it
Bifulco
Maurizio
M
Maina
Giuseppe
G
Tortorella
Alfonso
A
Gazzerro
Patrizia
P
Proto
Maria Chiara
MC
Di Filippo
Carmela
C
Monteleone
Francesco
F
Canestrelli
Benedetta
B
Buonerba
Giovanna
G
Bogetto
Filippo
F
Maj
Mario
M
D000328:Adult; D017668:Age of Onset; D000483:Alleles; D000581:Amidohydrolases / Q000235:genetics*; D001714:Bipolar Disorder / Q000453:epidemiology* / Q000235:genetics*; D015992:Body Mass Index; D003865:Major Depressive Disorder / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics*; D013406:Suicide, Attempted / Q000706:statistics & numerical data; D000099252:Fatty Acid Amide Hydrolases
D000581:Amidohydrolases; D043884:Receptor, Cannabinoid, CB1; D000099252:Fatty Acid Amide Hydrolases