title: [Preparation and characterization of oridonin submicron emulsions].
abstract: OBJECTIVE
  To prepare the oridonin submicron emulsion and characterize their properties.
  
  
  METHODS
  High pressure homogenization method was employed to prepare the oridonin submicron emulsion and such properties as size, Zeta potential and viscosity were characterized.
  
  
  RESULTS
  The results showed that the submicron emulsions was formed with the drug loading 1 g L(-1), particle size of (138.87 +/- 0.60) nm, zeta potential of (47.27 +/- 2.31) mV, pH value of (6.02 +/- 0.03) and viscosity of (1.78 +/- 0.015) MPa s, respectively.
  
  
  CONCLUSIONS
  The method is feasible and the submicron emulsions has stable properties. Experiments offer a new formulation of oridonin for clinical application.
authors.affiliation: Shanghai Hengrui Pharmaceuticals Co. Ltd., Shanghai, China. yul@shhrp.com
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.forename: Xinyong
authors.initials: X
authors.lastname: Tong
authors.forename: Yan
authors.initials: Y
authors.lastname: Tan
mesh_terms: D002626:Chemistry, Pharmaceutical; D045786:Diterpenes, Kaurane / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry; D010316:Particle Size; D014783:Viscosity
chemical_list: D045786:Diterpenes, Kaurane; D004655:Emulsions; C011959:oridonin