title: Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
abstract: Parkinson disease (PD) is a chronic neurodegenerative disorder with a cumulative prevalence of greater than one per thousand. To date three independent genome-wide association studies (GWAS) have investigated the genetic susceptibility to PD. These studies implicated several genes as PD risk loci with strong, but not genome-wide significant, associations. In this study, we combined data from two previously published GWAS of Caucasian subjects with our GWAS of 604 cases and 619 controls for a joint analysis with a combined sample size of 1752 cases and 1745 controls. SNPs in SNCA (rs2736990, p-value = 6.7 x 10(-8); genome-wide adjusted p = 0.0109, odds ratio (OR) = 1.29 [95% CI: 1.17-1.42] G vs. A allele, population attributable risk percent (PAR%) = 12%) and the MAPT region (rs11012, p-value = 5.6 x 10(-8); genome-wide adjusted p = 0.0079, OR = 0.70 [95% CI: 0.62-0.79] T vs. C allele, PAR%= 8%) were genome-wide significant. No other SNPs were genome-wide significant in this analysis. This study confirms that SNCA and the MAPT region are major genes whose common variants are influencing risk of PD.
authors.affiliation: John P. Hussman Institute for Human Genomics, University of Miami, FL 33136, USA.
authors.forename: Todd L
authors.initials: TL
authors.lastname: Edwards
authors.forename: William K
authors.initials: WK
authors.lastname: Scott
authors.forename: Cherylyn
authors.initials: C
authors.lastname: Almonte
authors.forename: Amber
authors.initials: A
authors.lastname: Burt
authors.forename: Eric H
authors.initials: EH
authors.lastname: Powell
authors.forename: Gary W
authors.initials: GW
authors.lastname: Beecham
authors.forename: Liyong
authors.initials: L
authors.lastname: Wang
authors.forename: Stephan
authors.initials: S
authors.lastname: Züchner
authors.forename: Ioanna
authors.initials: I
authors.lastname: Konidari
authors.forename: Gaofeng
authors.initials: G
authors.lastname: Wang
authors.forename: Carlos
authors.initials: C
authors.lastname: Singer
authors.forename: Fatta
authors.initials: F
authors.lastname: Nahab
authors.forename: Burton
authors.initials: B
authors.lastname: Scott
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Stajich
authors.forename: Margaret
authors.initials: M
authors.lastname: Pericak-Vance
authors.forename: Jonathan
authors.initials: J
authors.lastname: Haines
authors.forename: Jeffery M
authors.initials: JM
authors.lastname: Vance
authors.forename: Eden R
authors.initials: ER
authors.lastname: Martin
mesh_terms: D055106:Genome-Wide Association Study; D006801:Humans; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D051844:alpha-Synuclein / Q000235:genetics* / Q000378:metabolism; D016875:tau Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C497604:SNCA protein, human; D051844:alpha-Synuclein; D016875:tau Proteins