Synthesis and biological evaluation of caffeic acid 3,4-dihydroxyphenethyl ester.
A high-yield synthesis of caffeic acid 3,4-dihydroxyphenethyl ester (1) has been achieved through Knoevenagel condensation of 3,4-dihydroxybenzaldehyde and 3,4-dihydroxyphenethyl monomalonate as the key step. Compound 1 was tested against a 56-cell-line cytotoxicity panel and for its free-radical-scavenging activity in the DPPH test.
Zhang
Zhizhen
Z
Jiangxi Doctors Science and Technology R&D Co., Ltd., Nanchang 330029, People's Republic of China.
Xiao
Binghua
B
Chen
Qi
Q
Lian
Xiao-Yuan
XY
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology; D002109:Caffeic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004952:Esters; D005260:Female; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008297:Male; D015394:Molecular Structure; D010851:Picrates / Q000494:pharmacology
C523599:3-(3,4-dihydroxyphenyl)acrylic acid 2-(3,4-dihydroxyphenyl)ethyl ester; D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D002109:Caffeic Acids; D004952:Esters; D016166:Free Radical Scavengers; D010851:Picrates; C548196:caffeic acid 3,4-dihydroxyphenethyl ester; C004931:1,1-diphenyl-2-picrylhydrazyl