title: Episodic memory and impairment of an early encoding process in schizophrenia.
abstract: Investigations of memory impairment in schizophrenia have frequently revealed a strategic processing deficit at encoding. The authors studied an early encoding process, refreshing (in this case, thinking of a stimulus that has just-previously been presented), and its impact on recognition memory in schizophrenia. Following simultaneous presentation of three words or a single word in the top, middle, or bottom position of the screen, 25 patients with schizophrenia and 25 control participants saw and read a new word (read condition), or a word presented on the previous screen (repeat condition), or saw a dot indicating that they should think of and say the last word to have appeared in that position (refresh condition). Later, on a surprise test, participants were asked to recognize words seen previously and give a Remember, Know, or Guess response according to whether they recognized each on the basis of conscious recollection, familiarity, or guessing. The cognitive operation of refreshing was impaired in schizophrenia: patients were slower on 1-word trials and less accurate on 3-word trials to refresh a word, and their Remember responses did not benefit from refreshing.
authors.affiliation: INSERM U796, University Paris Descartes, Faculty of Medecine Paris Descartes, and Sainte-Anne Hospital, France.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Grillon
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Krebs
authors.forename: Raphaël
authors.initials: R
authors.lastname: Gourevitch
authors.forename: Anne
authors.initials: A
authors.lastname: Giersch
authors.forename: Caroline
authors.initials: C
authors.lastname: Huron
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time / Q000502:physiology; D011932:Reading; D021641:Recognition, Psychology / Q000502:physiology*; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology; D014706:Verbal Learning / Q000502:physiology; D055815:Young Adult