Colchicinoids from Colchicum crocifolium Boiss. (Colchicaceae).
A new colchicinoid from Colchicum crocifolium Boiss. (Colchicaceae) was isolated and identified as N,N-dimethyl-N-deacetyl-(-)-cornigerine (5), along with four known compounds, but new to the species: (-)-colchicine (1), (-)-demecolcine (2), (-)-N-methyl-(-)-demecolcine (3) and 3-demethyl-N-methyl-(-)-demecolcine (4). All isolated compounds showed potent cytotoxicity against a human cancer cell panel.
Alali
Feras Q
FQ
Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan. falali@just.edu.jo
Gharaibeh
Ahmad A
AA
Ghawanmeh
Abdullah
A
Tawaha
Khaled
K
Qandil
Amjad
A
Burgess
Jason P
JP
Sy
Arlene
A
Nakanishi
Yuka
Y
Kroll
David J
DJ
Oberlies
Nicholas H
NH
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003079:Colchicum / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D013057:Spectrum Analysis / Q000379:methods
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts