title: Influence of height, weight, and body mass index on optic disc parameters.
abstract: OBJECTIVE
  To examine the influence of body height, body weight, and body mass index (BMI) on optic disc parameters in a population-based study.
  
  
  METHODS
  The Singapore Malay Eye Study examined 3280 persons of Malay ethnicity, aged 40 to 80 years, of whom 2329 (71.0%) had reliable retinal scanning confocal laser tomography images for analyses. Intraocular pressure (IOP) was ascertained by Goldmann applanation tonometry. Body height and weight were measured with standardized protocols; BMI was calculated as weight (kilograms)/height squared (meters). Sociodemographic information was collected in an interviewer-administered questionnaire.
  
  
  RESULTS
  In univariate analyses, body height, weight, and BMI were significantly associated with optic cup area, rim area, and cup-to-disc area ratio (all with P < 0.05) but none of the anthropometric parameters was significantly associated with optic disc area (all with P > 0.05). In multiple regression analyses after adjustment for age, sex, optic disc size, axial length, education, family income, and IOP, each SD increase in body height was associated with a 0.042-mm(2) decrease in optic rim area and a 0.020 increase in optic cup-to-disc area ratio; each SD decrease in body weight was associated with a 0.013-mm(2) decrease in optic rim area and a 0.010 increase in optic cup-to-disc ratio; and each SD decrease in BMI was associated with a 0.021-mm(2) decrease in optic rim area and a 0.010 increase in optic cup-to-disc ratio.
  
  
  CONCLUSIONS
  Persons who are taller or have lower BMI have a smaller neuroretinal rim area and a larger optic cup-to-disc area ratio.
authors.affiliation: Singapore Eye Research Institute, Singapore National Eye Center, Singapore.
authors.forename: Yingfeng
authors.initials: Y
authors.lastname: Zheng
authors.forename: Carol Y L
authors.initials: CY
authors.lastname: Cheung
authors.forename: Tien Y
authors.initials: TY
authors.lastname: Wong
authors.forename: Paul
authors.initials: P
authors.lastname: Mitchell
authors.forename: Tin
authors.initials: T
authors.lastname: Aung
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000208:ethnology; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000208:ethnology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis / Q000208:ethnology; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000473:pathology*; D012846:Singapore / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014065:Tonometry, Ocular; D058609:Visual Field Tests; D014794:Visual Fields