The association of metabolic syndrome and its components with serum prostate-specific antigen levels in a Korean-screened population.
BACKGROUND
Metabolic syndrome plays a potential role in the etiology of prostate cancer and is associated with the increase in prostatic growth rate in patients with benign prostatic hyperplasia. However, the influence of metabolic syndrome on prostate-specific antigen (PSA) level remains unclear.


METHODS
Data were obtained from 23,601 men ages 40 years or older without a history of prostate cancer who underwent general health screening tests between 2006 and 2007 at Asan Medical Center. The criteria for metabolic syndrome were consistent with those defined by the NCEP-ATPIII-AHA/NHLBI statement. Multivariate linear regression analysis was used to determine the independent effects of age, body mass index (BMI), metabolic syndrome, and each component of metabolic syndrome, on PSA level.


RESULTS
Geometric mean PSA level increased linearly and significantly with increasing age and decreasing BMI (P < 0.001). Although the geometric mean PSA levels were lower in men with metabolic syndrome than in those without the condition, metabolic syndrome no longer retained a statistically significant association with PSA after the adjustment for age and BMI (P = 0.850). Among five metabolic components, higher waist circumference and fasting plasma glucose level were significantly associated with lower PSA (P = 0.021 and P = 0.001), whereas hypertension was significantly associated with higher PSA (P < 0.001), after complete adjustment for age, BMI, and other metabolic components.


CONCLUSIONS
In our screened population, metabolic syndrome was not associated with PSA level. The lack of association between metabolic syndrome and PSA level may reflect the heterogeneous relationship between each metabolic risk factor and PSA level.
Jeong
In Gab
IG
Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Hwang
Seung Sik
SS
Kim
Hong Kyu
HK
Ahn
Hanjong
H
Kim
Choung-Soo
CS
D000328:Adult; D000368:Aged; D044466:Asian People; D015992:Body Mass Index; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000209:etiology
D017430:Prostate-Specific Antigen