Proline-rich hypothalamic polypeptide has opposite effects on the proliferation of human normal bone marrow stromal cells and human giant-cell tumour stromal cells.
In the present study we carried out experiments in vitro and in vivo and investigated the effect of proline-rich polypeptide (PRP) on the proliferation and effectiveness of colony formation of MMSCs in vitro. Various routes and doses of PRP administration to rats increased the number of MMSCs in bone marrow and spleen. Our research revealed opposite effects of PRP on the proliferation of bone marrow stromal cells obtained from normal humans and stromal cells isolated from a human giant-cell tumour.
Chailakhyan
R K
RK
Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Gamaleya str., 18, 123098, Moscow, Russian Federation. info@riem.ru
Gerasimov
Yu V
YV
Chailakhyan
M R
MR
Galoyan
Armen A
AA
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects*; D049109:Cell Proliferation; D002478:Cells, Cultured; D005870:Giant Cell Tumors / Q000473:pathology*; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects; D039902:Multipotent Stem Cells / Q000166:cytology / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017154:Stromal Cells / Q000166:cytology / Q000187:drug effects; D013997:Time Factors
D010455:Peptides