Temporal codes for amplitude contrast in auditory cortex.
The encoding of sound level is fundamental to auditory signal processing, and the temporal information present in amplitude modulation is crucial to the complex signals used for communication sounds, including human speech. The modulation transfer function, which measures the minimum detectable modulation depth across modulation frequency, has been shown to predict speech intelligibility performance in a range of adverse listening conditions and hearing impairments, and even for users of cochlear implants. We presented sinusoidal amplitude modulation (SAM) tones of varying modulation depths to awake macaque monkeys while measuring the responses of neurons in the auditory core. Using spike train classification methods, we found that thresholds for modulation depth detection and discrimination in the most sensitive units are comparable to psychophysical thresholds when precise temporal discharge patterns rather than average firing rates are considered. Moreover, spike timing information was also superior to average rate information when discriminating static pure tones varying in level but with similar envelopes. The limited utility of average firing rate information in many units also limited the utility of standard measures of sound level tuning, such as the rate level function (RLF), in predicting cortical responses to dynamic signals like SAM. Response modulation typically exceeded that predicted by the slope of the RLF by large factors. The decoupling of the cortical encoding of SAM and static tones indicates that enhancing the representation of acoustic contrast is a cardinal feature of the ascending auditory pathway.
Malone
Brian J
BJ
Center for Neural Science at New York University, New York, New York 10003, USA. bmalone@ohns.ucsf.edu
Scott
Brian H
BH
Semple
Malcolm N
MN
D000161:Acoustic Stimulation / Q000379:methods; D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001303:Auditory Cortex / Q000166:cytology / Q000502:physiology*; D001306:Auditory Pathways / Q000502:physiology; D001307:Auditory Perception / Q000502:physiology*; D001309:Auditory Threshold / Q000502:physiology; D001931:Brain Mapping; D008253:Macaca mulatta; D008297:Male; D056004:Molecular Dynamics Simulation; D009474:Neurons / Q000502:physiology; D011237:Predictive Value of Tests; D011571:Psychoacoustics; D011930:Reaction Time / Q000502:physiology; D017603:Signal Detection, Psychological / Q000502:physiology*; D013223:Statistics as Topic; D013997:Time Factors