[Research advances in Sirt1 gene].
As the most homologic homologue of silent information regulator 2 of yeast, Sirt1 gene is extensively expressed in mature tissues, and is rich in early embryo and reproductive cells. It is involved in the regulation of gene transcription, energy metabolism and cell aging. It promotes fat mobilization in adipocytes and glucose production in liver and regulates insulin secretion in islet beta cell. Furthermore, Sirt1 gene is an essential endogenous apoptosis inhibitor. In future, it may be used as new drug targets or applied in other disease management modalities.
Qiao
Ai-jun
AJ
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Beijing 100005, China.
Zhiao
Jin
J
Liu
Xiao-jun
XJ
Shao
Di
D
Zhu
Liu-luan
LL
Cui
An-fang
AF
Kong
Xing-xing
XX
Fang
Fu-de
FD
Chang
Yong-sheng
YS
D000818:Animals; D006801:Humans; D056564:Sirtuin 1 / Q000235:genetics / Q000378:metabolism / Q000502:physiology
D056564:Sirtuin 1