Metoclopramide-induced encephalopathy in Parkinson disease.
A case of prolonged encephalopathy and worsened parkinsonism in a Parkinson disease patient exposed to a short course of metoclopramide is described. Parkinson disease (PD) is the second most common neurodegenerative disease in the United States. Because of the increased susceptibility to adverse drug effects, PD presents a special challenge to physicians. Anti-emetic drugs such as metoclopramide are widely used and may be particularly deleterious to PD patients due to blockade of dopamine receptors.
Robottom
Bradley J
BJ
Departments of Neurology and Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA. BRobottom@som.umaryland.edu
Shulman
Lisa M
LM
Anderson
Karen E
KE
Weiner
William J
WJ
D000368:Aged; D000932:Antiemetics / Q000009:adverse effects* / Q000627:therapeutic use; D003248:Constipation / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000009:adverse effects* / Q000627:therapeutic use; D020258:Neurotoxicity Syndromes / Q000150:complications / Q000209:etiology*; D010300:Parkinson Disease / Q000150:complications; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*
D000932:Antiemetics; D008787:Metoclopramide