Real-time monitoring of drug release.
A new prodrug system, assembled using a distinctive coumarin linker, was demonstrated to report real-time activation and drug release in vitro.
Weinstain
Roy
R
School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv 69978, Israel.
Segal
Ehud
E
Satchi-Fainaro
Ronit
R
Shabat
Doron
D
D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage* / Q000494:pharmacology; D015394:Molecular Structure; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry*
D018906:Antineoplastic Agents, Alkylating; D003374:Coumarins; D011355:Prodrugs; C030123:coumarin; D008558:Melphalan