title: Cytogenetic evaluation of traffic policemen occupationally exposed to vehicular exhaust.
abstract: OBJECTIVE
  Automobile exhaust consists of many toxic components and is considered to be a major health concern in urban areas. Traffic policemen are occupationally exposed to vehicular exhaust during the traffic control. Hence, the present study was aimed to evaluate genotoxic effects of vehicular exhaust in traffic policemen in Hyderabad, south India.
  
  
  METHODS
  Analysis of chromosomal aberrations was carried out in 136 traffic policemen, including 78 non smokers and 58 smokers who were exposed to vehicular exhaust for a period of 1-28 yr. For comparison, 115 healthy males including 69 non smokers and 46 smokers of the same age group and socio-economic status (who were not exposed to any chemical or radiation at their workplace) were studied.
  
  
  RESULTS
  A significant increase (P<0.05) was observed in the mean frequency of chromosomal aberrations in non smoker and smoker traffic policemen (6.48 and 8.96 respectively) when compared to their respective control groups (3.35 and 4.30). According to the age a significant increase in the frequency of chromosomal aberrations was observed both in control and exposed groups (P<0.05). As the duration of exposure increased in traffic policemen, there was a corresponding increase in the frequency of chromosomal aberrations.
  
  
  CONCLUSIONS
  Cytogenetic damage was more pronounced in smokers when compared to non smokers. Age and duration of exposure also appear to play a vital role in causing cytogenetic damage. Thus the present study suggests that the induction of cytogenetic damage might be due to the cumulative effect of smoking, age and duration of exposure to vehicular exhaust.
authors.affiliation: Department of Environmental Toxicology, Institute of Genetics & Hospital for Genetic Diseases, Osmania University, Hyderabad, India. sreedevi_vreey@yahoo.co.in
authors.forename: V
authors.initials: V
authors.lastname: Sree Devi
authors.forename: V
authors.initials: V
authors.lastname: Durga Rao
authors.forename: V V
authors.initials: VV
authors.lastname: Hara Gopal
authors.forename: B
authors.initials: B
authors.lastname: Siva Prasad
authors.forename: G
authors.initials: G
authors.lastname: Sandhya Devi
authors.forename: A
authors.initials: A
authors.lastname: Jyothy
authors.forename: P P
authors.initials: PP
authors.lastname: Reddy
authors.forename: M
authors.initials: M
authors.lastname: Hema Prasad
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000633:toxicity*; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009153:Mutagens / Q000633:toxicity; D016273:Occupational Exposure; D016495:Police; D001335:Vehicle Emissions / Q000633:toxicity*; D055815:Young Adult
chemical_list: D000395:Air Pollutants, Occupational; D009153:Mutagens; D001335:Vehicle Emissions