title: Multicenter analysis of 80 solid organ transplantation recipients with post-transplantation lymphoproliferative disease: outcomes and prognostic factors in the modern era.
abstract: PURPOSE Adult post-transplantation lymphoproliferative disease (PTLD) has a reported 3-year overall survival (OS) of 35% to 40%. The impact of rituximab on the outcome of PTLD is not well defined. METHODS We examined the clinical features and outcomes among a large cohort of solid organ transplantation (SOT) -related patients with PTLD who were recently treated at four Chicago institutions (from January 1998 to January 2008). Results Eighty patients with PTLD were identified who had a median SOT-to-PTLD time of 48 months (range, 1 to 216 months). All patients had reduction of immunosuppression as part of initial therapy, whereas 59 (74%) of 80 patients received concurrent first-line rituximab with or without chemotherapy. During 40-month median follow-up, 3-year progression-free survival (PFS) for all patients was 57%, and the 3-year overall survival (OS) rate was 62%. Patients who received rituximab-based therapy as part of initial treatment had 3-year PFS of 70% and OS 73% compared with 21% (P < .0001) and 33% (P = .0001), respectively, without rituximab. Notably, of all relapses, only 9% (4 of 34 patients) occurred beyond 12 months from PTLD diagnosis. On multivariate regression analysis, three factors were associated with progression and survival: CNS involvement (PFS, 4.70; P = .01; OS, 3.61; P = .04), bone marrow involvement (PFS, 2.95; P = .03; OS, 3.14; P = .03), and hypoalbuminemia (PFS, 2.96; P = .05; OS, 3.64; P = .04). Furthermore, a survival model by multivariate CART analysis that was based on number of adverse factors present (ie, 0, 1, > or = 2) was formed: 3-year PFS rates were 84%, 66%, 7%, respectively, and 3-year OS rates were 93%, 68%, 11%, respectively (P < .0001). CONCLUSION This large, multicenter, retrospective analysis suggests significantly improved PFS and OS associated with early rituximab-based treatment in PTLD. In addition, clinical factors at diagnosis identified patients with markedly divergent outcomes.
authors.affiliation: DO, MSc, Division of Hematology/Oncology, 676 N St Clair S, Suite 850, Chicago, IL, 60611, USA. a-evens@northwestern.edu
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Evens
authors.forename: Kevin A
authors.initials: KA
authors.lastname: David
authors.forename: Irene
authors.initials: I
authors.lastname: Helenowski
authors.forename: Beverly
authors.initials: B
authors.lastname: Nelson
authors.forename: Dixon
authors.initials: D
authors.lastname: Kaufman
authors.forename: Sheetal M
authors.initials: SM
authors.lastname: Kircher
authors.forename: Alla
authors.initials: A
authors.lastname: Gimelfarb
authors.forename: Elise
authors.initials: E
authors.lastname: Hattersley
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Mauro
authors.forename: Borko
authors.initials: B
authors.lastname: Jovanovic
authors.forename: Amy
authors.initials: A
authors.lastname: Chadburn
authors.forename: Patrick
authors.initials: P
authors.lastname: Stiff
authors.forename: Jane N
authors.initials: JN
authors.lastname: Winter
authors.forename: Jayesh
authors.initials: J
authors.lastname: Mehta
authors.forename: Koen
authors.initials: K
authors.lastname: Van Besien
authors.forename: Stephanie
authors.initials: S
authors.lastname: Gregory
authors.forename: Leo I
authors.initials: LI
authors.lastname: Gordon
authors.forename: Jamile M
authors.initials: JM
authors.lastname: Shammo
authors.forename: Scott E
authors.initials: SE
authors.lastname: Smith
authors.forename: Sonali M
authors.initials: SM
authors.lastname: Smith
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016377:Organ Transplantation / Q000009:adverse effects*; D011183:Postoperative Complications / Q000188:drug therapy*; D011379:Prognosis; D012189:Retrospective Studies; D000069283:Rituximab; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab