title: Amplitude-integrated electroencephalography in patients with acute encephalopathy with refractory, repetitive partial seizures.
abstract: We report amplitude-integrated EEG findings in two children with acute encephalopathy with refractory, repetitive partial seizures. Both patients had a febrile illness one week before the onset of seizure. They had reduction of consciousness and repetitive seizures refractory to first-line antiepileptic drugs. Seizure frequency rapidly increased and evolved into status epilepticus. Continuous seizure monitoring with amplitude-integrated EEG revealed frequent subclinical seizures which were missed by direct observation. In addition, the site of origin of seizures was multifocal, and seizure foci shifted from one hemisphere to the other. Their seizures were controlled after an administration of high-dose phenobarbital. Continuous seizure monitoring with amplitude-integrated EEG will contribute to correct estimation of seizure burden and efficacy of antiepileptic drugs in children with acute encephalopathy with refractory, repetitive partial seizures.
authors.affiliation: Department of Pediatrics, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan. okumura@juntendo.ac.jp
authors.forename: Akihisa
authors.initials: A
authors.lastname: Okumura
authors.forename: Mitsutaka
authors.initials: M
authors.lastname: Komatsu
authors.forename: Shinpei
authors.initials: S
authors.lastname: Abe
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kitamura
authors.forename: Kotoko
authors.initials: K
authors.lastname: Matsui
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ikeno
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D004569:Electroencephalography / Q000379:methods* / Q000706:statistics & numerical data*; D005260:Female; D005334:Fever / Q000150:complications; D006801:Humans; D010634:Phenobarbital / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D013226:Status Epilepticus / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants; D010634:Phenobarbital