Angiotensin-converting enzyme gene polymorphism in overweight and obese Turkish patients with insulin resistance.
The aim of this study was to analyze the distribution of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in obese Turkish patients with insulin resistance (IR). Sixty-two obese Turkish patients with IR were enrolled in this study. One hundred healthy people without IR were recruited as the control group. ACE amplification was performed by polymerase chain reaction. The frequency of the DD genotype was significantly higher in obese patients with IR than in control subjects. Of sixty-two patients, 1 (1.6%) had an II genotype, 22 (35.5%) had an ID genotype, and 39 (62.9%) had a DD genotype. The frequency of the I allele in the patient group was significantly lower than in controls. We found that the frequency of the DD genotype was higher in obese Turkish patients with IR. ACE gene I/D polymorphism may be associated with obesity in the Turkish population.
Akin
Fulya
F
Department of Endocrinology and Metabolism, Faculty of Medicine, Pamukkale University, Denizli, Turkey. fulyaendo@yahoo.com.tr
Turgut
Sebahat
S
Bastemir
Mehmet
M
Turgut
Gunfer
G
Kursunluoglu
Raziye
R
Karasu
Ugur
U
Guclu
Aydin
A
D000273:Adipose Tissue / Q000033:anatomy & histology; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics*; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D050177:Overweight / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D014421:Turkey; D014527:Uric Acid / Q000097:blood; D055105:Waist Circumference / Q000235:genetics
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D014527:Uric Acid; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A