title: Intermittent simulated moving bed chromatography: 1. Design criteria and cyclic steady-state.
abstract: The intermittent SMB (I-SMB) process is a multi-column chromatographic process, which is a modification of the conventional SMB process, has been applied so far only in the sugar industry and is claimed to achieve higher productivity. In the I-SMB process the time interval between two port switches is divided in two sub-intervals, and only during the first the product streams are collected. The potential of the I-SMB technology is demonstrated in the case of the separation of a binary mixture subject to the linear isotherm by using both the equilibrium theory of chromatography and detailed simulations. It is shown that a I-SMB with only four columns can achieve much higher separation performance than a SMB unit with four columns.
authors.affiliation: Institute of Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092 Zurich, Switzerland.
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Katsuo
authors.forename: Marco
authors.initials: M
authors.lastname: Mazzotti
mesh_terms: D000327:Adsorption; D002845:Chromatography / Q000379:methods*; D003198:Computer Simulation; D008956:Models, Chemical; D013237:Stereoisomerism; D013816:Thermodynamics