title: Dramatically elevated circulating tumor cell numbers in a patient with small cell neuroendocrine carcinoma of the prostate.
abstract: Detection of circulating tumor cells in whole blood is a useful prognostic tool for patients with castration-resistant prostate cancer, as well as for patients with metastatic breast cancer and colorectal carcinoma. In this report, we present the case of a patient with neuroendocrine small cell prostate cancer with normal prostate-specific antigen levels throughout the course of disease but who had markedly elevated circulating tumor cells, as detected with the CellSearch (Veridex) system.
authors.affiliation: Department of Medical Oncology, Nevada Cancer Institute, Las Vegas, NV 89135, USA.
authors.forename: Fanny
authors.initials: F
authors.lastname: Chan
authors.forename: Oscar
authors.initials: O
authors.lastname: Goodman
authors.forename: Louis
authors.initials: L
authors.lastname: Fink
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Vogelzang
authors.forename: David
authors.initials: D
authors.lastname: Pomerantz
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Khoury
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D018278:Carcinoma, Neuroendocrine / Q000097:blood* / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000097:blood* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen