title: [Transoral carbon dioxide laser surgery for treatment of hypopharyngeal carcinoma].
abstract: OBJECTIVE
  To evaluate the feasibility and curative effects of transoral CO2 laser in treatment of hypopharyngeal carcinoma.
  
  
  METHODS
  The retrospective analysis included 24 cases of hypopharyngeal carcinoma from 1994 to 2005 in the Department of Head and Neck. All cases were treated with endoscopic laser surgery and adjuvant selective neck dissection or radiotherapy. The follow-up period was more than 3 years. Twenty-four patients (21 male, 3 female) were classified as follows: 14 cases were T1N0M0, 4 were T1N1M0, 1 was T1N2bM0, 3 were T2N0M0 and 2 were T2N2bM0.
  
  
  RESULTS
  Kaplan-Meier survival analysis showed the overall 5-year survival rate was 74.9%, and the 5-year survival rate of T1 lesions and T2 lesions was 78.8% and 60.1%, respectively. The overall 5-year local control rate was 82.1% and 5-year larynx preservation rate was 87.0%. Six of 7 patients with local-regional recurrences underwent salvage surgery and radiotherapy. Finally 4 of them died of recurrence again and 2 were survival. The other one of 7 patients had distant metastasis, and died after radiochemotherapy. One patient died of non-neoplastic diseases. Two patients experienced minor complications with conventional ambulatory treatment without sequelae. All survival patients had laryngeal preservation except the one who received salvage surgery of the hypopharynx and larynx.
  
  
  CONCLUSIONS
  Endoscopic CO2 laser surgery with adjuvant selective or modified radical neck dissection and radiotherapy is an alternative for the treatment of selected hypopharyngeal carcinoma, associated with satisfying curative effects and a high larynx preservation rate.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing, China.
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Huang
authors.forename: Xin
authors.initials: X
authors.lastname: Ni
authors.forename: Ju-gao
authors.initials: JG
authors.lastname: Fang
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Chen
authors.forename: Zhen-kun
authors.initials: ZK
authors.lastname: Yu
authors.forename: Xue-jun
authors.initials: XJ
authors.lastname: Chen
authors.forename: Wei-guo
authors.initials: WG
authors.lastname: Zhou
authors.forename: Jun-wei
authors.initials: JW
authors.lastname: Huang
authors.forename: De-min
authors.initials: DM
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000601:surgery*; D053685:Laser Therapy; D054020:Lasers, Gas / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D012189:Retrospective Studies