title: Efficient one-pot synthesis of spirooxindole derivatives catalyzed by L-proline in aqueous medium.
abstract: An efficient one-pot synthesis of spirooxindole derivatives by three-component reaction of isatins, malononitrile (cyanoacetic ester) and 1,3-dicarbonyl compounds in water in the presence of l-proline is reported. This new protocol has the advantages of environmental friendliness, higher yields, shorter reaction times, low cost, and convenient operation.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
authors.forename: Yuling
authors.initials: Y
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Chunling
authors.initials: C
authors.lastname: Shi
authors.forename: Daqing
authors.initials: D
authors.lastname: Shi
authors.forename: Shunjun
authors.initials: S
authors.lastname: Ji
mesh_terms: D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis*; D011392:Proline / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis*; D014867:Water
chemical_list: D007211:Indoles; D013141:Spiro Compounds; D014867:Water; D011392:Proline