Unusual approach to branched 3-alkynylamides and to 1,5-dihydropyrrol-2-ones.
Rare carboxamide branched alkynes such as 11a can be readily obtained by reaction of the electrophilic 4-alkylidene isoxazolinones with isocycanides followed by nitrosative cleavage of the heterocyclic ring. N-Iodosuccinimide induced ring closure in the presence of a nucleophile results in the formation of new iodopyrrolinones such as 16c.
Dias-Jurberg
Igor
I
Laboratoire de Synthèse Organique, CNRS UMR 7652, Ecole Polytechnique, 91128 Palaiseau Cedex, France.
Gagosz
Fabien
F
Zard
Samir Z
SZ