title: The treatment of cerebral salt wasting with fludrocortisone in a child with lissencephaly.
abstract: Hyponatremia is the most frequent electrolyte disorder in critically ill neurological patients. The major differential diagnoses in this situation are the syndrome of inappropriate antidiuretic hormone secretion, marked by inappropriate retention of free water, and cerebral salt wasting, characterized by excessive urinary loss of sodium and resulting in polyuria and extracellular volume contraction. Cerebral salt wasting is a syndrome of hyponatremia due to increased urine output and excessive natriuresis described in patients with central nervous system disease. Although cerebral salt wasting has been well described in neurosurgical patients, data regarding pediatric patients is sparse. We present a 34-month-old boy with lissencephaly who developed cerebral salt wasting after brain biopsy. The patient was treated with hypertonic saline and multiple antiepileptic drugs. Fludrocortisone supplementation effectively treated cerebral salt wasting.
authors.affiliation: Ankara Diskapi Pediatric Disease Education and Investigation Hospital, Pediatric Intensive Care Unit, Ankara, Turkey. doktorhalil@gmail.com
authors.forename: Halil
authors.initials: H
authors.lastname: Ozdemir
authors.forename: Zehra
authors.initials: Z
authors.lastname: Aycan
authors.forename: Aydan
authors.initials: A
authors.lastname: Degerliyurt
authors.forename: Ayse
authors.initials: A
authors.lastname: Metin
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D002675:Child, Preschool; D005438:Fludrocortisone / Q000627:therapeutic use*; D006801:Humans; D007010:Hyponatremia / Q000188:drug therapy / Q000209:etiology*; D054082:Lissencephaly / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D011141:Polyuria / Q000188:drug therapy / Q000209:etiology; D017096:Prion Diseases / Q000175:diagnosis / Q000601:surgery*; D012640:Seizures / Q000188:drug therapy / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D005438:Fludrocortisone