[The role of TGFbeta1 and IL-13 in cellular signal transduction of hepatic fibrosis of schistosomiasis].
Liver fibrosis is characterized by an abnormal hepatic accumulation of extracellular matrix (ECM) that results from both increased deposition and reduced degradation of collagen fibres. Some studies show that transforming growth factor beta1 (TGF-beta1), alternatively activated macrophage (aaM) and interleukin 13 (IL-13) play a key role in the evolution of fibrosis, of which TGF-beta1 and IL-13 become research hotspots. TGF-beta1 mainly activates hepatic stellate cells (HSC) through TGF-beta1/Smad signal pathway, while IL-13 seems to play a rather crucial role through JAK-STAT6 signal pathway. aaM is an important source of TGF-beta1 and activated with IL-13. This paper reviews the role of those signaling molecules in cellular signal transduction of hepatic fibrosis of schistosomiasis japonica, and provides some targets for future drug development.
Li
Jing
J
Anhui Medical University, Hefei, China.
Wang
Wei
W
Shen
Ji-Long
JL
D005109:Extracellular Matrix / Q000378:metabolism; D018793:Interleukin-13 / Q000378:metabolism*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008103:Liver Cirrhosis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D012552:Schistosomiasis / Q000378:metabolism; D015398:Signal Transduction; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
D018793:Interleukin-13; D053773:Transforming Growth Factor beta1