title: Plasma aldosterone and glomerular filtration in hypertensive patients with preserved renal function.
abstract: There is increasing interest in the role of aldosterone in the pathophysiology of hypertension, cardiovascular disease and deteriorating renal function. The aim of this study was to investigate the relationship between aldosterone and the glomerular filtration rate (GFR) in hypertensive patients with preserved renal function. The study involved 186 consecutive hypertensive patients with a GFR >60 mL/min. The GFR was determined using the Modification of Diet in Renal Disease (MDRD) equation and the patients' plasma aldosterone levels were measured. Patients with a GFR between 60-89 mL/min had a significantly higher plasma aldosterone level than those with a GFR >90 mL/min (20.02 ng/dL vs. 15.3 ng/dL; P< .05). Multivariate analysis showed that the plasma aldosterone level was independently associated with the GFR (B=-7.36; P< .001). In hypertensive patients with preserved kidney function, the plasma aldosterone level was observed to increase as the GFR decreased.
authors.affiliation: Unidad de Hipertensión Arterial, Servicio de Cardiología, Hospital Universitario San Juan, Alicante, Spain.
authors.forename: Julián
authors.initials: J
authors.lastname: Roldán
authors.forename: Pedro
authors.initials: P
authors.lastname: Morillas
authors.forename: Jesús
authors.initials: J
authors.lastname: Castillo
authors.forename: Helder
authors.initials: H
authors.lastname: Andrade
authors.forename: Silvia
authors.initials: S
authors.lastname: Guillén
authors.forename: Daniel
authors.initials: D
authors.lastname: Núñez
authors.forename: Juan
authors.initials: J
authors.lastname: Quiles
authors.forename: Vicente
authors.initials: V
authors.lastname: Bertomeu
mesh_terms: D000450:Aldosterone / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology*; D007668:Kidney / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000450:Aldosterone