Comparison of lung asbestos fiber content in cancer subjects with healthy individuals with no known history of occupational asbestos exposure in Korea.
To evaluate the effects of environmental asbestos exposure on the inducement of lung cancer, pulmonary asbestos and non-asbestos fiber content was determined in 36 normal Korean subjects and 38 lung cancer subjects with no known occupational history of asbestos exposure. Pulmonary asbestos fiber content was measured by transmission electron microscopy (TEM) with energy-dispersive x-ray analysis after applying a low-temperature ashing procedure. Chrysotile fibers were the major fiber type found in the lungs of the Korean subjects. The asbestos fiber concentrations found in the lungs of normal males (25) and females (11) were 0.26 x 10(6) fibers/g of dry lung tissue and 0.16 x 10(6) fibers/g of dry lung tissue, respectively. The asbestos concentrations found in the lungs of cancer subjects were 0.16 x 10(6) fibers/g of dry lung tissue for 32 males and 0.44 x 10(6) fibers/g of dry lung tissue for 6 females. No statistical difference was found in pulmonary asbestos content between the normal and lung cancer subjects, whereas a statistical difference was noted between normal and lung cancer subjects with respect to lung non-asbestos content, indicating a potential role for non-asbestos fibers being associated with lung cancer.
Han
Jeong Hee
JH
Center for Occupational Toxicology, Occupational Safety and Health Research Institute, Daejeon, Korea.
Park
Jung Duck
JD
Sakai
Kiyoshi
K
Hisanaga
Naomi
N
Chang
Hee Kyung
HK
Lee
Yong Hwan
YH
Kwon
Il Hoon
IH
Choi
Byung Sun
BS
Chung
Yong Hyun
YH
Kim
Hyeon Yeong
HY
Yang
Jung Sun
JS
Cho
Myung Haing
MH
Yu
Il Je
IJ
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001194:Asbestos / Q000302:isolation & purification* / Q000633:toxicity*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008168:Lung / Q000737:chemistry; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced* / Q000453:epidemiology; D008875:Middle Aged; D016273:Occupational Exposure; D056910:Republic of Korea / Q000453:epidemiology; D055815:Young Adult
D001194:Asbestos