title: Chorda tympani nerve analysis with electron microscopy in chronic suppurative otitis media.
abstract: CONCLUSIONS
  Chronic suppurative otitis media causes some disturbance to the chorda tympani nerve (CTN), which may affect the facial nerve. It is not possible to perform a biopsy of the main truncus of the facial nerve, therefore studies of the CTN might show possible pathologic or physiologic changes of the facial nerve in the future.
  
  
  OBJECTIVE
  The specific aim of this study was to investigate the effects of chronic suppurative otitis media on the CTN.
  
  
  METHODS
  The tympanic segments of CTNs were collected for ultrastructural investigations in patients with chronic suppurative otitis media who underwent canal wall-down tympanoplasty. The study population comprised 10 patients, 7 males, 3 females; the age range was 16-66 years, and the mean age was 38. Qualitative and semiquantitative evaluations were performed on the specimens of CTN by electron microscopy.
  
  
  RESULTS
  Our histopathologic examinations showed that there were changes of varying severity in all the CTNs such as scarcity of unmyelinated nerve fibers, Schwann cell nucleus condensation, scarcity of Schwann cell cytoplasm, adaxonal vacuolation and edema, myelin sheath disintegration, shrunken electron-dense axoplasm, increased collagen fibers, adaxonal circular lamellar complex, interstitial edema, and vacuolation of Schwann cell cytoplasm.
authors.affiliation: Otorhinolaryngology Department, Vakif Gureba Training and Research Hospital, Fatih, Istanbul. aysenurmeric@yahoo.com <aysenurmeric@yahoo.com>
authors.forename: Aysenur Meric
authors.initials: AM
authors.lastname: Teker
authors.forename: Orhan
authors.initials: O
authors.lastname: Gedikli
authors.forename: Huseyin
authors.initials: H
authors.lastname: Altun
authors.forename: Arzu Yasemin
authors.initials: AY
authors.lastname: Korkut
authors.forename: Bulent
authors.initials: B
authors.lastname: Ahishali
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001369:Axons / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology; D002814:Chorda Tympani Nerve / Q000648:ultrastructure*; D003593:Cytoplasm / Q000473:pathology; D004487:Edema / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009186:Myelin Sheath / Q000473:pathology; D010035:Otitis Media, Suppurative / Q000473:pathology* / Q000601:surgery; D011446:Prospective Studies; D012583:Schwann Cells / Q000473:pathology; D014433:Tympanoplasty; D014617:Vacuoles / Q000473:pathology; D055815:Young Adult