Recent advances in association studies of osteoarthritis susceptibility genes.
Osteoarthritis (OA) is a polygenic disease with a definite genetic component, and recent advances in genome research have enabled us to investigate OA susceptibility genes. Several research groups, including ours, have reported the identification of OA susceptibility genes, mainly using candidate gene association studies. However, we are now entering the era of genome-wide association studies (GWAS). Here, we review recent progress in the study of susceptibility genes for OA, focusing in particular on GWAS and large-scale replication studies.
Dai
Jin
J
Center for Genomic Medicine, Riken, Japan.
Ikegawa
Shiro
S
D024142:Collagen Type VI / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods / Q000639:trends*; D055428:Growth Differentiation Factor 5 / Q000235:genetics; D006801:Humans; D010003:Osteoarthritis / Q000235:genetics*; D011544:Pseudogenes
C531065:COL6A4P1 protein, human; D024142:Collagen Type VI; C525893:GDF5 protein, human; D055428:Growth Differentiation Factor 5