title: Tipping the balance by manipulating post-translational modifications.
abstract: Bacteria use a variety of mechanisms during infection to ensure their survival including the delivery of virulence factors via a type III secretion system into the infected cell. The factors exhibit diverse activities that in many cases mimic eukaryotic mechanisms used by the host to defend against infection. Herein we describe a class of effectors that use post-translational modifications, some reversible and others irreversible, to manipulate host signaling systems to subvert the host response.
authors.affiliation: Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Broberg
authors.forename: Kim
authors.initials: K
authors.lastname: Orth
mesh_terms: D001419:Bacteria / Q000472:pathogenicity*; D001426:Bacterial Proteins / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000382:microbiology / Q000502:physiology*; D005786:Gene Expression Regulation; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D037521:Virulence Factors