Liposomes for drug delivery to mitochondria.
Efficacy of therapeutically active drugs known to act on intracellular targets can be enhanced by specific delivery to the site of action. Triphenylphosphonium cations can be used to create subcellular targeted liposomes that efficiently deliver drugs to mitochondria, thus enhancing their therapeutic action.
Boddapati
Sarathi V
SV
Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA.
D'Souza
Gerard G M
GG
Weissig
Volkmar
V
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002463:Cell Membrane Permeability; D002518:Ceramides / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008081:Liposomes / Q000737:chemistry* / Q000493:pharmacokinetics*; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy; D009943:Organophosphorus Compounds / Q000737:chemistry*; D013229:Stearic Acids / Q000737:chemistry*
D000970:Antineoplastic Agents; D002518:Ceramides; D008081:Liposomes; D009943:Organophosphorus Compounds; D013229:Stearic Acids; C101954:N-caproylsphingosine