Obesity as a risk factor for coronary events in Japanese patients with hypercholesterolemia on low-dose simvastatin therapy.
OBJECTIVE
We previously reported that obesity (defined as a body mass index (BMI) >or=25 kg/m(2)) was not an independent risk factor for coronary heart disease (CHD) in hypercholesterolemic patients without a history of CHD from the Japan Lipid Intervention Trial (J-LIT). In this study, the obese J-LIT subgroup was further analyzed to assess CHD risk.


METHODS
In the J-LIT study, patients received simvastatin treatment (usually at 5 mg/day) for 6 years. A total of 38,385 patients (mean age: 57.7+/-7.9, 12,111 men) without prior CHD and/or stroke were analyzed.


RESULTS
In this cohort, 181 CHD (acute myocardial infarction or sudden cardiac death) were observed. Obesity (n=12,929) was not an independent risk factor for CHD (relative risk; 1.18, 95% confidence interval; 0.87?1.59) after adjustment for the major risk known factors, such as age, sex, hypertension, diabetes mellitus (DM), and smoking. However, blood pressure, triglycerides, and fasting plasma glucose all increased, while high-density lipoprotein-cholesterol decreased, with increased BMI. The percentage of patients having two or three risk factors (such as dyslipidemia, hypertension, and DM) also increased with increased BMI.


CONCLUSIONS
Obesity was not an independent risk factor for CHD in hypercholesterolemic patients on statin therapy; however, it is important to control obesity, a condition in which CHD risks accumulate, in order to improve associated risk factors along with the treatment of each risk factor, thus further reducing the risk of CHD.
Saito
Yasushi
Y
Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan. yasushi@faculty.chiba-u.jp
Kita
Toru
T
Mabuchi
Hiroshi
H
Matsuzaki
Masunori
M
Matsuzawa
Yuji
Y
Nakaya
Noriaki
N
Oikawa
Shinichi
S
Sasaki
Jun
J
Shimamoto
Kazuaki
K
Itakura
Hiroshige
H
D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D015992:Body Mass Index; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000150:complications* / Q000188:drug therapy* / Q000208:ethnology; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000473:pathology*; D007564:Japan; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000188:drug therapy* / Q000208:ethnology; D012307:Risk Factors; D019821:Simvastatin / Q000627:therapeutic use*
D000924:Anticholesteremic Agents; D019821:Simvastatin