Chewing the fat on tumor cell metabolism.
Tumor cells undergo a metabolic shift toward specific bioenergetic (glycolysis) and anabolic (protein and lipid synthesis) processes that promote rapid growth. Nomura et al. (2010) now demonstrate that an increase in monoacylglycerol lipase (MAGL) drives tumorigenesis through the lipolytic release and remodeling of free fatty acids.
Yecies
Jessica L
JL
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Manning
Brendan D
BD
D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008994:Monoacylglycerol Lipases / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*
D005227:Fatty Acids; D008994:Monoacylglycerol Lipases