A short, chemoenzymatic route to chiral beta-aryl-gamma-amino acids using reductases from anaerobic bacteria.
A short chemoenzymatic synthesis of beta-aryl-gamma-aminobutyric acids has been developed, based on a highly enantioselective biocatalytic reduction of beta-aryl-beta-cyano-alpha,beta-unsaturated carboxylic acids.
Fryszkowska
Anna
A
Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, United Kingdom. anna.fryszkowska@manchester.ac.uk
Fisher
Karl
K
Gardiner
John M
JM
Stephens
Gill M
GM
D000693:Anaerobiosis; D001419:Bacteria / Q000201:enzymology*; D055162:Biocatalysis; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism*; D013237:Stereoisomerism; D013379:Substrate Specificity; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000096:biosynthesis* / Q000138:chemical synthesis* / Q000737:chemistry
D005680:gamma-Aminobutyric Acid; D010088:Oxidoreductases