[Value of loss of CD10 expression in pathologic diagnosis of follicular lymphoma].
OBJECTIVE
To study the value of loss of CD10 expression in the diagnosis and differential diagnosis of follicular lymphoma (FL).


METHODS
One hundred and twenty-six cases of FL and 31 cases of reactive follicular hyperplasia (RFH) were studied with routine microscopy and immunohistochemistry.


RESULTS
Loss of CD10 expression was observed in 37 cases (29.4%) of FL. Three patterns of CD10 loss were demonstrated, as follows: diffuse CD10 loss in all of the neoplastic follicles (33/37, 89%), CD10 loss in most follicles (3/37, 8%) and CD10 loss in only a few follicles (1/37, 3%). In general, loss of CD10 was frequently seen in higher-grade FL. Morphologically, the cases with CD10 loss showed follicular architecture. The neoplastic follicles in high-grade FL were of various sizes and showed irregular margins, while those in low-grade FL were relatively uniform in size with regular margin. Sometimes, the CD10-negative FL cells contained a clear cytoplasm, mimicking monocytoid B cells. On the other hand, CD10 expression was found in all of the 31 cases of RFH studied, with the exception of occasional individual or regressed follicles.


CONCLUSIONS
The expression of CD10 differs in FL and RFH. Loss of CD10 expression is seen mainly in FL. It is thus considered as a valuable parameter in differentiating between FL and RFH.
Xie
Jian-lan
JL
Department of Pathology, Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing 100050, China.
Zhou
Xiao-ge
XG
Jin
Yan
Y
Zhu
Hong
H
Zheng
Yuan-yuan
YY
Zhang
Shu-hong
SH
Zhang
Yan-ning
YN
Zhang
Xiao-jing
XJ
Zheng
Xiao-dan
XD
D000293:Adolescent; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008224:Lymphoma, Follicular / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015260:Neprilysin / Q000378:metabolism*; D019310:Pseudolymphoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D013160:Splenic Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D014067:Tonsillar Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
D015260:Neprilysin