How bugs make lassos.
In this issue of Chemistry & Biology, Knappe et al. report the generation of a series of mutants of the bacterial peptide capistruin to help unravel key aspects of the biosynthesis of its unusual lasso structure.
Rosengren
K Johan
KJ
The University of Queensland, Institute for Molecular Bioscience, Brisbane, QLD 4072, Australia.
Craik
David J
DJ
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001430:Bacteriocins / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D047169:Cyclotides / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D005810:Multigene Family; D010455:Peptides / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D017433:Protein Structure, Secondary
D001426:Bacterial Proteins; D001430:Bacteriocins; D047169:Cyclotides; D010455:Peptides; D010456:Peptides, Cyclic; C533129:capistruin; C091930:kalata B1; C020411:microcin