Mitochondrial respiratory chain and creatine kinase activities in mdx mouse brain.
In this study we investigated energy metabolism in the mdx mouse brain.To this end, prefrontal cortex, cerebellum, hippocampus, striatum, and cortex were analyzed. There was a decrease in Complex I but not in Complex II activity in all structures. There was an increase in Complex III activity in striatum and a decrease in Complex IV activity in prefrontal cortex and striatum. Mitochondrial creatine kinase activity was increased in hippocampus, prefrontal cortex, cortex, and striatum. Our results indicate that there is energy metabolism dysfunction in the mdx mouse brain.
Tuon
Lisiane
L
Laboratório de Neurociências and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil.
Comim
Clarissa M
CM
Fraga
Daine B
DB
Scaini
Giselli
G
Rezin
Gislaine T
GT
Baptista
Bruna R
BR
Streck
Emilio L
EL
Vainzof
Mariz
M
Quevedo
João
J
D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000473:pathology; D002531:Cerebellum / Q000201:enzymology / Q000473:pathology; D002540:Cerebral Cortex / Q000201:enzymology / Q000473:pathology; D003342:Corpus Striatum / Q000201:enzymology / Q000473:pathology; D003402:Creatine Kinase / Q000378:metabolism*; D004195:Disease Models, Animal; D042967:Electron Transport Complex I / Q000378:metabolism*; D042963:Electron Transport Complex II / Q000378:metabolism*; D014450:Electron Transport Complex III / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology; D006624:Hippocampus / Q000201:enzymology / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018101:Mice, Inbred mdx; D020388:Muscular Dystrophy, Duchenne / Q000201:enzymology* / Q000473:pathology; D017397:Prefrontal Cortex / Q000201:enzymology / Q000473:pathology
D042963:Electron Transport Complex II; D003576:Electron Transport Complex IV; D003402:Creatine Kinase; D042967:Electron Transport Complex I; D014450:Electron Transport Complex III