title: Monocyte expression of adhesion molecules during low- and high-flux polysulfone hemodialysis and the effect of atorvastatin administration.
abstract: OBJECTIVE
  Aims of the present study are to examine the effects of atorvastatin administration and the influence of membrane flux on adhesion molecules expression on monocytes.
  
  
  METHODS
  We studied CD11b, CD18 and CD62L expression on monocytes (flow cytometry) in 32 patients, 16 on low-flux (LFD) and 16 on high-flux (HFD) polysulfone hemodialysis, before and after dialysis and also after administration of atorvastatin 20 mg/day for 6 months.
  
  
  RESULTS
  After hemodialysis, expression of CD11b and CD18 increased and expression of CD62L decreased. After atorvastatin administration there was a decrease in pre-dialysis monocyte expression of CD11b and CD18, and an increase in the expression of CD62L compared to pre-dialysis baseline values. There were no statistically significant differences in expression of all three molecules between LFD and HFD groups.
  
  
  CONCLUSIONS
  Polysulfone dialysis process activates monocytes irrespectively of the membrane flux. Atorvastatin use is associated with reduced monocyte activation.
authors.affiliation: Nephrology Department, IASIO Hospital - General Clinic of Kallithea, Athens, Greece. stavroulopoulos@yahoo.co.uk
authors.forename: Aristeidis
authors.initials: A
authors.lastname: Stavroulopoulos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Petras
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kakavas
authors.forename: Ioannis
authors.initials: I
authors.lastname: Agroyannis
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Stamatelou
authors.forename: Georgios
authors.initials: G
authors.lastname: Vyssoulis
authors.forename: Ioannis T
authors.initials: IT
authors.lastname: Papadakis
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D000328:Adult; D000368:Aged; D000069059:Atorvastatin; D039481:CD11b Antigen / Q000096:biosynthesis; D018821:CD18 Antigens / Q000096:biosynthesis; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D018592:Cross-Over Studies; D005260:Female; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy; D019041:L-Selectin / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D011108:Polymers; D011758:Pyrroles / Q000627:therapeutic use*; D006435:Renal Dialysis / Q000295:instrumentation / Q000379:methods*; D013450:Sulfones
chemical_list: D039481:CD11b Antigen; D018821:CD18 Antigens; D015815:Cell Adhesion Molecules; D006538:Heptanoic Acids; C509295:ITGAM protein, human; D011108:Polymers; D011758:Pyrroles; D013450:Sulfones; D019041:L-Selectin; C017662:polysulfone P 1700; D000069059:Atorvastatin