Gamma-secretase inhibitors--do they have a role in the treatment of B cell lymphoma?
Swaminathan
Sankar
S
Division of Infectious Diseases, Department of Medicine, UF Shands Cancer Center, University of Florida, Gainesville, FL USA. sswamina@ufl.edu
D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002986:Clinical Trials as Topic; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D020031:Epstein-Barr Virus Infections; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006566:Herpesviridae Infections; D004854:Herpesvirus 4, Human / Q000472:pathogenicity; D019288:Herpesvirus 8, Human / Q000472:pathogenicity; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D054685:Lymphoma, Primary Effusion / Q000188:drug therapy / Q000473:pathology / Q000821:virology; D051379:Mice; D016513:Mice, SCID; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology / Q000821:virology; D051880:Receptors, Notch / Q000037:antagonists & inhibitors / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects; D014412:Tumor Virus Infections; D023041:Xenograft Model Antitumor Assays
D004791:Enzyme Inhibitors; D009363:Neoplasm Proteins; D051880:Receptors, Notch; D053829:Amyloid Precursor Protein Secretases