title: [Complete resection of Pancoast tumor following induction chemoradiotherapy improves survival].
abstract: OBJECTIVE
  Pancoast tumors are some of the most challenging thoracic malignant diseases to treat because of their proximity to vital structures at the thoracic inlet. We retrospectively analyzed 23 patients with pT3-4, N0-3 Pancoast tumors who underwent combined chest wall resection including the 1st rib, and discuss the anatomical considerations, assessment of induction therapy, and surgical approaches for these cancers.
  
  
  METHODS
  Between 1983 and 2006, 23 patients with Pancoast tumors underwent combined resection of the 1st rib at our institute. Of those, 21 were male and 2 were female, with an average age of 58 years. There were 10 each of squamous cell carcinoma and adenocarcinoma, 2 large cell carcinoma, and 1 adenosquamous carcinoma. Over the past decade, induction chemoradiotherapy (>40Gy) was employed before surgery.
  
  
  RESULTS
  A posterior approach was employed in 14 patients, an anterior approach in 7, and a combined anterior and posterior approach in 2. Sixteen patients underwent complete resection. One of 7 patients undergoing incomplete resection (4.3%) died on the 45th postoperative day. The 3- and 5-year survival rates were 50 and 22%, respectively, for patients with complete resection. No case survived for more than 8 months out of the 7 patients with incomplete resection. Fourteen patients with pN0 showed significantly better survival than those with pN1-3 (p = 0.0053).
  
  
  CONCLUSIONS
  Recent literature and our results suggest that patients with pN0 and/or a pathological complete response (pCR) after induction chemoradiotherapy could achieve long-term survival after complete resection.
authors.affiliation: Department of Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Kodama
authors.forename: J
authors.initials: J
authors.lastname: Okami
authors.forename: J
authors.initials: J
authors.lastname: Maeda
authors.forename: T
authors.initials: T
authors.lastname: Tokunaga
authors.forename: R
authors.initials: R
authors.lastname: Kanzaki
authors.forename: A
authors.initials: A
authors.lastname: Fujiwara
authors.forename: M
authors.initials: M
authors.lastname: Higashiyama
mesh_terms: D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000601:surgery*; D008875:Middle Aged; D010178:Pancoast Syndrome / Q000401:mortality / Q000601:surgery*; D018714:Radiotherapy, Adjuvant