Research and development of universal influenza vaccines.
The continuous threat of influenza pandemics determines the urgency and necessity to develop safe and effective vaccines against divergent influenza viruses. This review describes the advancements in the research and development of universal influenza vaccines based on the relatively conserved sequences of M2e, HA, and other proteins of influenza viruses.
Du
Lanying
L
Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.
Zhou
Yusen
Y
Jiang
Shibo
S
D035843:Biomedical Research / Q000639:trends*; D017124:Conserved Sequence; D006389:Hemagglutinins, Viral / Q000235:genetics / Q000276:immunology; D006801:Humans; D007252:Influenza Vaccines / Q000235:genetics* / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology* / Q000517:prevention & control*; D022223:Vaccines, Subunit / Q000235:genetics / Q000276:immunology; D014763:Viral Matrix Proteins / Q000235:genetics / Q000276:immunology; D000086082:Viroporin Proteins
D006389:Hemagglutinins, Viral; D007252:Influenza Vaccines; D022223:Vaccines, Subunit; D014763:Viral Matrix Proteins; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins; C458881:hemagglutinin fusogenic peptide, influenza virus