title: [Administration of premedication with fexofenadine for paclitaxel-induced hypersensitive reactions in breast cancer patients complicated with closed-angle glaucoma].
abstract: Paclitaxel (PTX) is one of the most important breast cancer treatment drugs. However, severe hypersensitivity reactions such as decreases in blood pressure and impaired breathing occur with high frequency. For the prevention of such hypersensitivity reactions, administration of a premedication composed of three components, diphenhydramine, ranitidine (or famotidine), and dexamethasone, has been advised in package insert information of medicine. Administration of diphenhydramine is difficult in breast cancer patients complicated with closed-angle glaucoma, because diphenhydramine has a weak anticholinergic adverse effect which can induce mydriasis and glaucoma attack. We studied the prevention of severe hypersensitivity reactions and of glaucoma attack in 2 breast cancer patients complicated with closed angle glaucoma at our hospital from April 2007 to March 2008. We switched from diphenhydramine to fexofenadine as the medicine to prevent hypersensitivity reactions. Hypersensitivity reactions were not observed throughout all courses in both patients, and no glaucoma attack was observed.
authors.affiliation: Department of Pharmacy, National Hospital Organization Shikoku Cancer Center, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Komatsubara
authors.forename: Kyoko
authors.initials: K
authors.lastname: Miyoshi
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Kogure
authors.forename: Tetsuaki
authors.initials: T
authors.lastname: Matsuhisa
authors.forename: Hisae
authors.initials: H
authors.lastname: Eguchi
mesh_terms: D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy*; D004342:Drug Hypersensitivity / Q000517:prevention & control*; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D017239:Paclitaxel / Q000009:adverse effects*; D011292:Premedication; D016593:Terfenadine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D018926:Anti-Allergic Agents; D000972:Antineoplastic Agents, Phytogenic; D016593:Terfenadine; C093230:fexofenadine; D017239:Paclitaxel