Glycoxidative stress-induced damage on lipid profile in a fructose-enriched diet model of insulin resistance in rats.
OBJECTIVE
To study alterations in plasma lipid profile and oxidative damage to lipoprotein fractions (LF) and their fatty acids during an early insulin-resistant and increased oxidative state developed by a fructose-rich diet (FRD).


RESULTS
Wistar rats were fed a commercial diet with (FRD) or without (CD) 10% fructose in the drinking water. After 3 weeks, plasma glucose, triglyceride (TG), insulin (I), fructosamine (F), free fatty acids (FFA) and lipid profile (total cholesterol [TC] and HDL-C, LDL-C and VLDL-C sub-fractions) were determined. The insulin sensitivity HOMA index was assessed. FRD-fed rats had higher plasma TG, I, and F levels; increased HOMA; decreased HDL-C and LDL-C; augmented VLDL-C and TC/HDL-C, and TG/HDL-C atherogenic risk scores. LF of FRD rats had increased oxidative damage on the fatty acyl profile and in copper-induced lipoperoxidation.


CONCLUSIONS
Fructose feeding early increases the atherogenic risk inducing an insulin resistant-glycoxidative state that affects plasma lipid profiles.
García
M E
ME
Centro de Endocrinología Experimental y Aplicada, UNLP-CONICET La Plata, PAHO/WHO Collaborating Center, Argentina.
Marra
C A
CA
Rebolledo
O R
OR
D000284:Administration, Oral; D000818:Animals; D019422:Dietary Sucrose / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood*; D005632:Fructose / Q000008:administration & dosage / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar
D019422:Dietary Sucrose; D005227:Fatty Acids; D008055:Lipids; D008074:Lipoproteins; D005632:Fructose