title: Randomized, placebo-controlled, double-blind, parallel design trial of the efficacy and safety of Zestra in women with mixed desire/interest/arousal/orgasm disorders.
abstract: Over 256 women, age 21 to 65, with acquired mixed female sexual disorders participated in a 16-week randomized, placebo-controlled, double-blind study of Zestra, a topical botanical preparation. Routine outcome instruments measured efficacy and safety. Zestra was well tolerated. The only significant safety finding was mild-to-moderate genital burning seen only in Zestra-treated subjects (14.6%). Zestra provided significant desire, arousal, and treatment satisfaction benefits for a broadly generalized group of women with sexual difficulties.
authors.affiliation: Clinical Research Services Consulting, Grand Marais, Minnesota 55604, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Ferguson
authors.forename: Balakrishna
authors.initials: B
authors.lastname: Hosmane
authors.forename: Julia R
authors.initials: JR
authors.lastname: Heiman
mesh_terms: D000328:Adult; D002243:Carbolines / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D010938:Plant Oils; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy* / Q000453:epidemiology*; D000068581:Tadalafil; D055815:Young Adult
chemical_list: D002243:Carbolines; D010726:Phosphodiesterase Inhibitors; D010938:Plant Oils; D000068581:Tadalafil