title: Postoperative management of pulmonary endarterectomy and outcome.
abstract: Pulmonary artery thromboendarterectomy (PTE) has been regarded as a promising, potentially curative surgical procedure. However, PTE is associated with specific postoperative complications, such as reperfusion pulmonary edema and right heart failure leading to a considerable mortality of 7-24%. Despite its limitations PTE is a better surgical alternative to lung transplantation which carries high morbidity and mortality. The aim of the study is to analyze the efficacy, safety, morbidity and survival associated in the postoperative period and quality of life after six months of PTE in Indian patients. Forty-one patients with surgically correctable chronic thromboembolic pulmonary hypertension underwent pulmonary endarterectomy. All patients were in New York Heart Association (NYHA) Class II, III or IV. Preoperative mean pulmonary artery pressure was 40.98 +/- 9.29 mmHg and mean pulmonary vascular resistance was 418.39 +/- 95.88 dynes/sec/cm(-5). All patients were followed up to six months and a telephonic survey was conducted using a standard questionnaire. They were assessed and classified as per NYHA grading. There was a significant reduction in the mean pulmonary artery pressure (from 40.98 +/- 9.29 mmHg to 24.13 +/- 7.36 mmHg, P < 0.001) and pulmonary vascular resistance (from 418.39 +/- 95.88 dynes/sec/cm(-5) to 142.45 +/- 36.27 dynes/sec/cm(-5), P < 0.001) with a concomitant increase in the cardiac index (from 1.99 +/- 0.20 L/min/m 2 to 3.28 +/- 0.56 L/min/m 2 , P < 0.001) during the postoperative period. The mortality rate in our study was 12.19% (five patients). Ninety per cent of the patients reported a significant improvement in the quality of life and exercise tolerance after surgery compared to the preoperative state. Pulmonary endarterectomy is an effective and potentially curative surgical treatment for patients with severe chronic thromboembolic pulmonary hypertension. The current techniques of operation make the procedure relatively safe and long-term survival, NYHA functional status and exercise capacity improve significantly.
authors.affiliation: Narayana Hrudayalaya Institute of Medical Sciences, Bangalore, India. manvaram@yahoo.com
authors.forename: Ramakrishna M
authors.initials: RM
authors.lastname: Narayana Iyengar
authors.forename: Deviprasad
authors.initials: D
authors.lastname: Hegde
authors.forename: Binoy
authors.initials: B
authors.lastname: Chattuparambil
authors.forename: Ratan
authors.initials: R
authors.lastname: Gupta
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Patil
mesh_terms: D000328:Adult; D004691:Endarterectomy / Q000009:adverse effects* / Q000401:mortality; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000523:psychology / Q000601:surgery*; D008297:Male; D011183:Postoperative Complications / Q000628:therapy*; D011651:Pulmonary Artery / Q000601:surgery*; D011788:Quality of Life; D016896:Treatment Outcome