Hemostasis in neonates and children: pitfalls and dilemmas.
Developmental Hemostasis refers to the age-related changes in the coagulation system that are most marked during neonatal life and childhood. An understanding of these changes is crucial to the accurate diagnosis of hemostatic abnormalities in neonates and children. This paper explains the current understanding of developmental hemostasis and describes the common pitfalls observed in clinical practice through failure to implement the principles into routine diagnostic work. Finally, there is a brief discussion as to a potential physiological rationale for developmental hemostasis and the implications of this for hemostatic interventions in neonates and children. There remains a need for further study to improve our understanding of the implications of developmental hemostasis in normal growth and development.
Monagle
Paul
P
Department of Clinical Haematology, University of Melbourne, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia. paul.monagle@rch.org.au
Ignjatovic
Vera
V
Savoia
Helen
H
D000375:Aging / Q000502:physiology*; D001777:Blood Coagulation; D002648:Child; D002675:Child, Preschool; D006402:Hematologic Diseases / Q000175:diagnosis / Q000503:physiopathology; D006487:Hemostasis; D006801:Humans; D007231:Infant, Newborn