[Evaluation of the analgesic effects of the lumiracoxib compared with placebo in the 24 first postoperative hours].
OBJECTIVE
To test lumiracoxib used preemptively against a placebo,and to analyse the analgesic administration (dipirona and tramadol) in the 24 first postoperative hours.


METHODS
Sixty patients undergone to a breast aumentation, under epidural anesthesia, were selected and put randomly in two groups - GI and GII. Sixty minutes before the surgery, it was administered orally, one pill of lumiracoxib 400mg to the 30 GI patients and one pill of placebo to the 30 GII patients. The postoperative pain was evaluated through the visual analogic scale, ranged from 0 (painless) to 10 (most intensive pain), being applied to the patient whenever having pain. For the same scores or under 4, it was administered intravenously 15mg/kg of dipirona up to a maximum of 1g. For scores of 5, 6 or 7, the patient had intravenously 50mg of tramadol.Scores 8 or more were treated intravenously with 0,5 mg/kg of meperidine.


RESULTS
The scores in GI were significantly lower than the ones obtained in GII within the first 24 hours, with the need of 20% less dipirona and 56% of tramadol in this period of time. In the same way, it was observed that analgesic solicitation for the first time had a delay of 191 minutes in GI in comparison to GII.


CONCLUSIONS
The use of lumiracoxib preemptively, was effective in the treatment of postoperative pain, reducing considerably the consume of analgesics, and enlarging the time for the first medication.
Molon
Vilmar
V
Facudade de Medicina, Universidade de Caxias do Sul, Caxias do Sul, RS, Brasil.
Kruel
Cleber Dario Pinto
CD
Maioli
Desiré Tarso
DT
Caran
Juliana Zanrosso
JZ
Lovison
Raquel Cristina
RC
D000328:Adult; D000698:Analgesia; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage; D004008:Diclofenac / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004177:Dipyrone / Q000008:administration & dosage; D005260:Female; D006801:Humans; D010149:Postoperative Pain / Q000517:prevention & control*; D013997:Time Factors; D014147:Tramadol / Q000008:administration & dosage
D000701:Analgesics, Opioid; D000806:Angiotensin-Converting Enzyme Inhibitors; D004008:Diclofenac; D014147:Tramadol; D004177:Dipyrone; C473384:lumiracoxib