title: [Liver metastasis from sigmoid colon cancer showed a complete response to S-1 after recurrence with FOLFOX6 treatment].
abstract: A 48-year-old woman was referred to our hospital with complaints of appetite loss caused by a sigmoid colon cancer and multiple liver metastasis. To prevent bowel obstruction, a sigmoid colon resection was performed. On postoperative day 27, FOLFOX was begun for the liver metastasis. But FOLFOX6 was discontinued due to diarrheal symptoms of grade 3. The liver metastasis was pointed out again in CT after two months, and S-1 was begun. It became CR on CT again. S-1 can be expected to be an effective agent for the treatment of colon cancer with liver metastasis.
authors.affiliation: Senbon Hospital, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nobuhara
authors.forename: Naoshi
authors.initials: N
authors.lastname: Kubo
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Matuoka
authors.forename: Taihou
authors.initials: T
authors.lastname: Yo
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D004338:Drug Combinations; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010094:Oxonic Acid / Q000627:therapeutic use*; D012811:Sigmoid Neoplasms / Q000473:pathology* / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000077146:Irinotecan; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin