title: Blood loss during and after transurethral resection of prostate: a prospective study.
abstract: OBJECTIVE
  Transurethral resection of prostate (TURP) is the gold standard treatment for symptomatic prostatic bladder outlet obstruction. Haemorrhage during and after TURP can lead to significant morbidity and mortality. The purpose of this study was to assess the influence of anaesthesia, operating time, weight of resected prostatic tissue and its histology on blood loss during and after TURP and to revisit the available body of evidence in the literature of urology.
  
  
  METHODS
  This is a prospective study of a cohort of 100 consecutive patients who had undergone TURP over a period of one year, where the data was collected on a performa specifically designed for the study, which included the type of anaesthesia administered, resection time, amount of blood lost during and after TURP, weight of the resected prostatic tissue and histology.
  
  
  RESULTS
  Sixty seven patients underwent TURP under spinal anaesthesia (SA) and 33 under general anaesthesia (GA). The median intraoperative (SA: 89.95 (5-936); GA: 105.40 (5-517) mls), postoperative (SA: 72.37 (15-387); GA: 136.43 (11-969) mls) and total (SA: 162.32 (29-1200); GA: 241.83 (21-1251) mls) blood losses were not significantly different between the two groups (95% C.I. -9.90 to 19.22, p= 0.46). The total operating time (SA: 29.70 (10-55); GA: 29.80 (10-65) minutes) and weight of resected prostate (SA: 21.90 (3-45); GA: 18.00 (4-60) gms) were similar between the two groups. There was a trend towards increased blood loss when BPH was associated with prostatitis (N=8). Of these, 3 patients required blood transfusion as compared to 1 patient in rest of the group, although this was not statistically significant (95% C.I - 67.2 to 1120.4, p = 0.87).
  
  
  CONCLUSIONS
  The intraoperative, postoperative and total blood losses related to TURP were not influenced by the type of anaesthesia, resection time, weight of the resected prostate and the histology.
authors.affiliation: Department of Urology, Royal Gwent Hospital, Newport, Gwent, UK. shresthabm@doctors.net.uk
authors.forename: B M
authors.initials: BM
authors.lastname: Shrestha
authors.forename: K
authors.initials: K
authors.lastname: Prasopshanti
authors.forename: S S
authors.initials: SS
authors.lastname: Matanhelia
authors.forename: W B
authors.initials: WB
authors.lastname: Peeling
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000627:therapeutic use; D016063:Blood Loss, Surgical / Q000706:statistics & numerical data*; D001810:Blood Volume; D015331:Cohort Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D019106:Postoperative Hemorrhage / Q000209:etiology*; D011446:Prospective Studies; D011467:Prostate / Q000601:surgery*; D011470:Prostatic Hyperplasia / Q000601:surgery; D011471:Prostatic Neoplasms / Q000601:surgery; D011472:Prostatitis / Q000601:surgery; D020728:Transurethral Resection of Prostate / Q000009:adverse effects*; D014546:Urinary Catheterization; D014552:Urinary Tract Infections / Q000150:complications
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin