Disease-associated functions of IL-33: the new kid in the IL-1 family.
Interleukin-33 (IL-33), a newly described member of the IL-1 family, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The IL-33 receptor, consisting of ST2 and IL-1 receptor accessory protein, is also widely expressed, particularly by T helper 2 (T(H)2) cells and mast cells. IL-33 is host-protective against helminth infection and reduces atherosclerosis by promoting T(H)2-type immune responses. However, IL-33 can also promote the pathogenesis of asthma by expanding T(H)2 cells and mediate joint inflammation, atopic dermatitis and anaphylaxis by mast cell activation. Thus IL-33 could be a new target for therapeutic intervention across a range of diseases.
Liew
Foo Y
FY
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK. f.y.liew@clinmed.gla.ac.uk
Pitman
Nick I
NI
McInnes
Iain B
IB
D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D001249:Asthma / Q000276:immunology*; D050197:Atherosclerosis / Q000276:immunology*; D003876:Dermatitis, Atopic / Q000276:immunology*; D006373:Helminthiasis / Q000276:immunology*; D006801:Humans; D007375:Interleukin-1 / Q000276:immunology*; D000067596:Interleukin-33; D007378:Interleukins / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology
C506536:IL33 protein, human; D007375:Interleukin-1; D000067596:Interleukin-33; D007378:Interleukins