title: The influence of nutrigenetics on the lipid profile: interaction between genes and dietary habits.
abstract: Nutrigenetics is a new field with few studies in Latin America. Our aim is to investigate the way in which different genes related to the lipid profile influence the response to specific dietary habits. Eight polymorphisms on seven genes were investigated in a sample (n = 567) from Porto Alegre, RS, Brazil. All the volunteers completed a food diary that was then assessed and classified into nine food groups. A number of nutrigenetic interactions were detected primarily related to the apolipoprotein E (apoE) gene. For example, frequent consumption of foods rich in polyunsaturated fat resulted in the beneficial effect of increasing HDL-C only in individuals who were not carriers of the E*4 allele of the APOE gene, whereas variations in eating habits of E*4 carriers did not affect their HDL-C (P = 0.018). Our data demonstrate for the first time nutrigenetic interactions in a Brazilian population.
authors.affiliation: Health Sciences Institute, Centro Universitário Feevale, RS 239, No. 2755, B. Vila Nova, Novo Hamburgo, RS CEP 93352-000, Brazil. fabiana.andrade@feevale.br
authors.forename: Fabiana M
authors.initials: FM
authors.lastname: de Andrade
authors.forename: Andréa C
authors.initials: AC
authors.lastname: Bulhões
authors.forename: Sharbel W
authors.initials: SW
authors.lastname: Maluf
authors.forename: Jaqueline B
authors.initials: JB
authors.lastname: Schuch
authors.forename: Francine
authors.initials: F
authors.lastname: Voigt
authors.forename: Juliana F
authors.initials: JF
authors.lastname: Lucatelli
authors.forename: Alessandra C
authors.initials: AC
authors.lastname: Barros
authors.forename: Mara H
authors.initials: MH
authors.lastname: Hutz
mesh_terms: D000328:Adult; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics; D004034:Diet Surveys; D004843:Epistasis, Genetic / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics*; D008055:Lipids / Q000097:blood*; D008297:Male; D055442:Metabolome / Q000235:genetics; D008875:Middle Aged; D054647:Nutrigenomics; D011795:Surveys and Questionnaires
chemical_list: D001057:Apolipoproteins E; D008055:Lipids