Pregnancy after prophylactic total gastrectomy.
Hereditary diffuse gastric cancer is an autosomal dominant inherited cancer predisposition syndrome characterized by susceptibility to diffuse gastric and lobular breast cancers. Since current screening options for diffuse gastric cancer are ineffective, prophylactic total gastrectomy (PTG) is a recommended option for unaffected germline CDH1 mutation carriers. It is unknown whether pregnancy after surgery is possible or advisable due to potential maternal nutritional deficiencies. In this report we describe the pregnancy outcomes in three CDH1 mutation positive women after PTG and in a CDH1 mutation negative woman after total gastrectomy for early gastric cancer.
Kaurah
Pardeep
P
British Columbia Cancer Agency, University of British Columbia, 600 West 10th Avenue, Rm 3427, Vancouver, BC, V5Z 4E6, Canada.
Fitzgerald
Rebecca
R
Dwerryhouse
Sarah
S
Huntsman
David G
DG
D000328:Adult; D015703:Antigens, CD; D015820:Cadherins / Q000235:genetics; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D013274:Stomach Neoplasms / Q000235:genetics / Q000517:prevention & control*; D055815:Young Adult
D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins