title: Higher fibrinogen levels predict progression of coronary artery calcification in adults with type 1 diabetes.
abstract: OBJECTIVE
  To determine whether fibrinogen levels predict independently progression of coronary artery calcification (CAC) in adults with type 1 diabetes.
  
  
  METHODS
  Data from a prospective cohort--the Coronary Artery Calcification in Type 1 Diabetes Study--were evaluated. Fibrinogen levels at baseline were separated into quartiles. CAC was measured twice and averaged at baseline and at follow-up 2.4+/-0.4 years later. CAC progressors were defined as participants whose square-root transformed CAC volume increased by >or=2.5 mm3 or development of clinical coronary artery disease during the follow-up period.
  
  
  RESULTS
  Fibrinogen levels were higher in progressors than in non-progressors (276+/-61 mg/dl versus 259+/-61 mg/dl, p=0.0003). CAC progression, adjusted for known cardiovascular risk factors, increased in the highest quartile.
  
  
  CONCLUSIONS
  Higher fibrinogen levels predict CAC progression in type 1 diabetes subjects, independent of standard cardiovascular risk factors.
authors.affiliation: Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Health Sciences Center, Aurora CO 80045, USA. ticianacr@yahoo.com.br
authors.forename: T C
authors.initials: TC
authors.lastname: Rodrigues
authors.forename: J K
authors.initials: JK
authors.lastname: Snell-Bergeon
authors.forename: D M
authors.initials: DM
authors.lastname: Maahs
authors.forename: G L
authors.initials: GL
authors.lastname: Kinney
authors.forename: M
authors.initials: M
authors.lastname: Rewers
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000097:blood* / Q000473:pathology; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000473:pathology; D048909:Diabetes Complications / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D018450:Disease Progression; D005260:Female; D005340:Fibrinogen / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D005340:Fibrinogen