title: Estimation of wildlife hazard levels using interspecies correlation models and standard laboratory rodent toxicity data.
abstract: Toxicity data from laboratory rodents are widely available and frequently used in human health assessments as animal model data. This study explores the possibility of using single rodent acute toxicity values to predict chemical toxicity to a diversity of wildlife species and estimate hazard levels from modeled species sensitivity distributions (SSD). Interspecies correlation estimation (ICE) models predict toxicity values for untested species using the sensitivity relationship between measured toxicity values of two species. Predicted toxicity values can subsequently populate SSD for application in ecological risk assessments. Laboratory mouse and rat toxicity values were used to estimate toxicity to wildlife and the predicted values then were used to derive SSD hazard dose levels. Toxicity values were predicted within fivefold of measured toxicity values for 78% of ICE models using laboratory rat or mouse toxicity as a surrogate value. Hazard dose levels (HD5) were within fivefold of measured estimates for 72% of SSD developed using laboratory rodent ICE models. Rodents were most often in the least sensitive quartile of species sensitivity distributions, and therefore toxicity values alone may not adequately represent the toxicity to many species of concern without appropriate safety or assessment factors. Laboratory rodent toxicity data offer an additional source of information that can be used to predict hazard levels for wildlife species, and thus offer a starting point for both health and ecological risk assessment.
authors.affiliation: U. S. Environmental Protection Agency, Gulf Ecology Division, Gulf Breeze, Florida 32561, USA. awkerman.jill@epa.gov
authors.forename: Jill A
authors.initials: JA
authors.lastname: Awkerman
authors.forename: Sandy
authors.initials: S
authors.lastname: Raimondo
authors.forename: Mace G
authors.initials: MG
authors.lastname: Barron
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D000835:Animals, Wild; D003627:Data Interpretation, Statistical; D017753:Ecosystem; D004785:Environmental Pollutants / Q000032:analysis* / Q000378:metabolism / Q000633:toxicity*; D015386:Hazardous Substances / Q000032:analysis* / Q000378:metabolism / Q000633:toxicity*; D007287:Inorganic Chemicals / Q000032:analysis / Q000378:metabolism / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D009930:Organic Chemicals / Q000032:analysis / Q000378:metabolism / Q000633:toxicity; D051381:Rats; D018570:Risk Assessment; D012377:Rodentia; D013045:Species Specificity
chemical_list: D004785:Environmental Pollutants; D015386:Hazardous Substances; D007287:Inorganic Chemicals; D009930:Organic Chemicals