Room temperature direct alkynylation of 1,3,4-oxadiazoles with alkynyl bromides under copper catalysis.
The direct alkynylation reaction of 1,3,4-oxadiazoles with alkynyl bromides efficiently proceeds in the presence of a copper catalyst at room temperature to create the corresponding heteroaryl-alkynyl linkage in good yields. This direct coupling provides a rapid and convergent access to oxadiazole core pi-conjugated systems.
Kawano
Tsuyoshi
T
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Matsuyama
Naoto
N
Hirano
Koji
K
Satoh
Tetsuya
T
Miura
Masahiro
M