Polysaccharide-modified synthetic polymeric biomaterials.
This review presents an overview of polysaccharide-conjugated synthetic polymers and their use in tissue-engineered scaffolds and drug-delivery applications. This topic will be divided into four categories: (1) polymeric materials modified with non-mammalian polysaccharides such as alginate, chitin, and dextran; (2) polymers modified with mammalian polysaccharides such as hyaluronan, chondroitin sulfate, and heparin; (3) multi-polysaccharide-derivatized polymer conjugate systems; and (4) polymers containing polysaccharide-mimetic molecules. Each section will discuss relevant conjugation techniques, analysis, and the impact of these materials as micelles, particles, or hydrogels used in in-vitro and in-vivo biomaterial applications.
Baldwin
Aaron D
AD
Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA.
Kiick
Kristi L
KL
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D040761:Biomimetic Materials / Q000737:chemistry; D002236:Carbohydrate Conformation; D004337:Drug Carriers / Q000737:chemistry; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*; D023822:Tissue Engineering
D001672:Biocompatible Materials; D004337:Drug Carriers; D011108:Polymers; D011134:Polysaccharides