title: Smoking status is associated with serum high molecular adiponectin levels in community-dwelling Japanese men.
abstract: OBJECTIVE
  Serum high molecular weight (HMW) adiponectin improves insulin sensitivity, and a decreased level has been reported as a risk factor for the development of diabetes and coronary heart disease. This association may be further confounded by smoking, which is involved in the development of insulin resistance. The aim of this study was to determine whether smoking status is associated with serum HMW adiponectin levels in community-dwelling males.
  
  
  METHODS
  The cross-sectional study was carried out in 2002. Study participants without a clinical history of diabetes (724 men aged 60+/-14 (mean+/-standard deviation) (range, 20-89) years) were randomly recruited from a single community at an annual physical examination. They were classified into never-smokers, ex-smokers, light-smokers (<30 pack x year), and heavy-smokers (>or=30 pack x year).
  
  
  RESULTS
  Mean serum HMW adiponectin levels were significantly lower in the current smokers than in the never- and ex-smokers but showed no significant difference between the light and heavy-smokers. Multiple linear regression analyses revealed that smoking status was significantly associated with HMW adiponectin levels, as were age, BMI, alcohol consumption, triglycerides, and high-density lipoprotein cholesterol. Multivariate-adjusted mean serum HMW adiponectin levels were lowest in the heavy-smokers, and significantly decreased in heavy-smokers compared with never-smokers and ex-smokers of an age >or=60 years, BMI >or=22 kg/m(2), alcohol consumption >or=22.9 g of ethanol/day, and HOMA-IR >or=1.6.
  
  
  CONCLUSIONS
  Smoking status is associated with serum HMW adiponectin levels in community-dwelling Japanese men.
authors.affiliation: Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan. rykawamo@yahoo.co.jp
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kawamoto
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Tabara
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kohara
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miki
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ohtsuka
authors.forename: Tomo
authors.initials: T
authors.lastname: Kusunoki
authors.forename: Masanori
authors.initials: M
authors.lastname: Abe
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D006801:Humans; D007333:Insulin Resistance; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D012307:Risk Factors; D012907:Smoking / Q000097:blood* / Q000453:epidemiology; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin