title: RECQL5 helicase: connections to DNA recombination and RNA polymerase II transcription.
abstract: The RecQ family of helicases are traditionally viewed as recombination factors, important for maintaining genome stability. RECQL5 is unique among these proteins in being associated with RNA polymerase II, the enzyme responsible for transcribing all protein-encoding genes in eukaryotes. Here, we describe the possible implications of recent studies and discuss models for RECQL5 function.
authors.affiliation: Mechanisms of Transcription Laboratory, Clare Hall Laboratories, Cancer Research UK London Research Institute, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, United Kingdom.
authors.forename: Ozan
authors.initials: O
authors.lastname: Aygün
authors.forename: Jesper Q
authors.initials: JQ
authors.lastname: Svejstrup
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D042822:Genomic Instability; D006801:Humans; D012319:RNA Polymerase II / Q000378:metabolism*; D053484:RecQ Helicases / Q000737:chemistry / Q000378:metabolism*; D011995:Recombination, Genetic; D014158:Transcription, Genetic
chemical_list: D004247:DNA; D012319:RNA Polymerase II; D053484:RecQ Helicases