Mycobacterium tuberculosis Beijing genotype is an independent risk factor for tuberculosis treatment failure in Indonesia.
Animal studies have shown that the globally emerging Beijing genotype strains of Mycobacterium tuberculosis are more virulent than other strains. We examined whether Beijing strains increase treatment failure in a prospective cohort study in Indonesia. Among 818 tuberculosis cases, positive sputum culture results after 6 months of treatment were more common among patients infected with Beijing strains (33.4%) than among those infected with non-Beijing strains (relative risk, 1.94 [95% confidence interval, 1.26-3.00]), even after adjustment for differences in drug resistance. These data suggest that M. tuberculosis Beijing genotype strains have a higher capacity to withstand tuberculosis treatment, even in the absence of drug resistance.
Parwati
Ida
I
Department of Clinical Pathology, Hasan Sadikin Hospital, Medical Faculty, Universitas Padjadjaran, Bandung, Indonesia.
Alisjahbana
Bachti
B
Apriani
Lika
L
Soetikno
Rista D
RD
Ottenhoff
Tom H
TH
van der Zanden
Adri G M
AG
van der Meer
Jos
J
van Soolingen
Dick
D
van Crevel
Reinout
R
D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D005838:Genotype; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D008297:Male; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D011446:Prospective Studies; D012307:Risk Factors; D017211:Treatment Failure; D014376:Tuberculosis / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology*
D000995:Antitubercular Agents