Serum ivermectin levels after enteral and subcutaneous administration for Strongyloides hyperinfection: a case report.
An AIDS patient was diagnosed with Strongyloides stercoralis hyperinfection complicated by ileus. Serum ivermectin concentrations were very low after rectal administration, but increased after subcutaneous doses. Absorption of rectal ivermectin appears poor, and subcutaneous administration can increase serum levels quickly, which may improve treatment in critically ill patients.
Grein
Jonathan D
JD
Division of Infectious Diseases, Olive View-UCLA Medical Center, Sylmar, California, USA. jonathan.grein@cshs.org
Mathisen
Glenn E
GE
Donovan
Suzanne
S
Fleckenstein
Lawrence
L
D000285:Administration, Rectal; D000328:Adult; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000150:complications; D006801:Humans; D045823:Ileus / Q000150:complications; D007279:Injections, Subcutaneous; D007559:Ivermectin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D044967:Serum / Q000737:chemistry*; D017171:Strongyloides stercoralis / Q000302:isolation & purification*; D013322:Strongyloidiasis / Q000188:drug therapy* / Q000469:parasitology; D016896:Treatment Outcome
D000871:Anthelmintics; D007559:Ivermectin