Blood inflammatory proteins and risk of incident depression in the elderly.
BACKGROUND
It is unclear whether high levels of blood inflammatory proteins are associated with the risk of developing depression in late life.


METHODS
Blood C-reactive protein, interleukin (IL)-6, 1 -antichymotrypsin (ACT), intercellular adhesion molecule 1, and tumor necrosis factor were measured in an elderly cohort (n = 968). Major depression diagnosed according to clinical criteria and relevant depressive symptoms measured by the Geriatric Depression Scale (score 6 10) were assessed at baseline and 4 year later.


RESULTS
Baseline IL-6 and ACT were increased in both prevalent major depression and relevant depressive symptoms. Baseline ACT was increased in incident major depression. All associations weakened below significance after adjustment for possible confounders and multiple comparisons.


CONCLUSIONS
Blood inflammatory proteins do not predict the risk of developing depression in older age.
Forti
Paola
P
Department of Internal Medicine, Ageing, and Nephrology, University Hospital St. Orsola-Malpighi, Bologna, Italy. paola.forti@unibo.it
Rietti
Elisa
E
Pisacane
Nicoletta
N
Olivelli
Valentina
V
Mariani
Erminia
E
Chiappelli
Martina
M
Licastro
Federico
F
Ravaglia
Giovanni
G
D000368:Aged / Q000523:psychology*; D015331:Cohort Studies; D003863:Depression / Q000097:blood* / Q000453:epidemiology / Q000523:psychology*; D003865:Major Depressive Disorder / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007558:Italy / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D015233:Models, Statistical; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales
D018836:Inflammation Mediators