Plasma aldosterone and glomerular filtration in hypertensive patients with preserved renal function.
There is increasing interest in the role of aldosterone in the pathophysiology of hypertension, cardiovascular disease and deteriorating renal function. The aim of this study was to investigate the relationship between aldosterone and the glomerular filtration rate (GFR) in hypertensive patients with preserved renal function. The study involved 186 consecutive hypertensive patients with a GFR >60 mL/min. The GFR was determined using the Modification of Diet in Renal Disease (MDRD) equation and the patients' plasma aldosterone levels were measured. Patients with a GFR between 60-89 mL/min had a significantly higher plasma aldosterone level than those with a GFR >90 mL/min (20.02 ng/dL vs. 15.3 ng/dL; P< .05). Multivariate analysis showed that the plasma aldosterone level was independently associated with the GFR (B=-7.36; P< .001). In hypertensive patients with preserved kidney function, the plasma aldosterone level was observed to increase as the GFR decreased.
Roldán
Julián
J
Unidad de Hipertensión Arterial, Servicio de Cardiología, Hospital Universitario San Juan, Alicante, Spain.
Morillas
Pedro
P
Castillo
Jesús
J
Andrade
Helder
H
Guillén
Silvia
S
Núñez
Daniel
D
Quiles
Juan
J
Bertomeu
Vicente
V
D000450:Aldosterone / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology*; D007668:Kidney / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D000450:Aldosterone