title: Nonresponder patients with hepatitis C virus genotype 2/3 infection: a question of low systemic interferon concentrations?
abstract: Twelve of 303 per-protocol patients were nonresponders in a 12-week versus 24-week treatment study of hepatitis C virus (HCV) genotype 2/3 infection. The nonresponders had significantly lower interferon concentrations, as well as significantly greater mean age, body mass index, and viral load. Suboptimal drug concentrations may thus contribute to lack of response to therapy in patients with infection due to HCV genotype 2/3.
authors.affiliation: Department of Infectious Diseases, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Asa
authors.initials: A
authors.lastname: Alsiö
authors.forename: Peer Brehm
authors.initials: PB
authors.lastname: Christensen
authors.forename: Martti
authors.initials: M
authors.lastname: Färkkilä
authors.forename: Nina
authors.initials: N
authors.lastname: Langeland
authors.forename: Mads Rauning
authors.initials: MR
authors.lastname: Buhl
authors.forename: Court
authors.initials: C
authors.lastname: Pedersen
authors.forename: Kristine
authors.initials: K
authors.lastname: Mørch
authors.forename: Bart L
authors.initials: BL
authors.lastname: Haagmans
authors.forename: Johan
authors.initials: J
authors.lastname: Westin
authors.forename: Kristoffer
authors.initials: K
authors.lastname: Hellstrand
authors.forename: Gunnar
authors.initials: G
authors.lastname: Norkrans
authors.forename: Martin
authors.initials: M
authors.lastname: Lagging
mesh_terms: D000328:Adult; D000367:Age Factors; D000906:Antibodies / Q000097:blood; D000998:Antiviral Agents / Q000008:administration & dosage; D015992:Body Mass Index; D004359:Drug Therapy, Combination; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage* / Q000097:blood / Q000276:immunology; D008875:Middle Aged; D015999:Multivariate Analysis; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D012367:RNA, Viral / Q000032:analysis; D011994:Recombinant Proteins; D012254:Ribavirin / Q000008:administration & dosage; D019562:Viral Load
chemical_list: D000906:Antibodies; D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D012367:RNA, Viral; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C100416:peginterferon alfa-2a