title: N-terminal proB-type natriuretic peptide and homocysteine concentrations in athletes.
abstract: OBJECTIVE
  Several studies suggest that intense exercise may increase the athlete's thrombotic tendency. Available data on those metabolic alteration are still conflicting and their clinical significance is still worth of interest. The aim of the present study was to investigate if widely used markers of cardiac damage such as NT-proBNP levels are affected by homocysteine concentrations during sustained sport activities.
  
  
  METHODS
  Seventy-eight competitive, non-professional athletes were enrolled in the study; 70 healthy age matched subjects, recruited from blood donors, served as controls. Besides the general clinical determinations, the assessed variables included homocysteine, folate, vitamin B12, total and HDL cholesterol, LDH, CPK, NT-proBNP and IL-6.
  
  
  RESULTS
  The percentages of athletes with normal and elevated homocysteine levels resulted 46% and 54%, respectively. Mean NT-proBNP levels were significantly higher in athletes than in controls (1176.66 + or - 442.15 pg/mL versus 450.34 + or - 180.39 pg/mL). No correlation was found between homocysteine and NT-proBNP values.
  
  
  CONCLUSIONS
  The previously described "sport related" homocysteine is not related to other markers of cardiovascular stress such as NT-proBNP. Available data suggest that both hyperhomocysteinemia and high NT-proBNP levels in healthy young athletes could be interpreted as markers of metabolic and morphologic adaptation to training rather than a risk factor for cardio-vascular diseases.
authors.affiliation: Department of Health Sciences, University of Rome Foro Italico, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Fagnani
authors.forename: A
authors.initials: A
authors.lastname: Spaccamiglio
authors.forename: L
authors.initials: L
authors.lastname: Grasso
authors.forename: A
authors.initials: A
authors.lastname: Termine
authors.forename: A
authors.initials: A
authors.lastname: Angeli
authors.forename: F
authors.initials: F
authors.lastname: Pigozzi
authors.forename: P
authors.initials: P
authors.lastname: Borrione
mesh_terms: D000328:Adult; D015415:Biomarkers; D016022:Case-Control Studies; D003163:Competitive Behavior; D005260:Female; D006304:Health Status; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood*; D007249:Inflammation / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D009043:Motor Activity; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012307:Risk Factors; D013177:Sports; D013223:Statistics as Topic
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D006710:Homocysteine; D020097:Natriuretic Peptide, Brain