Prenatal hair development: implications for drug exposure determination.
Neonatal hair is a clinically important toxicological matrix, as it allows determination of in utero drug exposure. This paper serves to review the physiological development of the hair follicle and hair production during fetal life. An understanding of the mechanisms and timing of hair development in the prenatal period is critical to effectively assessing the time window of exposure determination associated with toxicological analysis of neonatal hair.
Gareri
Joey
J
Division of Clinical Pharmacology & Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada. joey.gareri@sickkids.ca
Koren
Gideon
G
D002454:Cell Differentiation; D004815:Epidermal Growth Factor / Q000378:metabolism; D004817:Epidermis / Q000196:embryology; D005260:Female; D006197:Hair / Q000196:embryology* / Q000378:metabolism; D006200:Hair Color / Q000502:physiology; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D053564:Keratins, Hair-Specific / Q000378:metabolism; D018811:Maternal Exposure; D008544:Melanocytes / Q000378:metabolism; D011247:Pregnancy; D015398:Signal Transduction / Q000502:physiology
D053823:Hedgehog Proteins; D053564:Keratins, Hair-Specific; D004815:Epidermal Growth Factor