title: Acute bilateral mydriasis associated with anti-GQ1b antibody.
abstract: Miller Fisher syndrome (MFS) is an autoimmune neuropathy characterized by external ophthalmoplegia, ataxia and areflexia. Mydriasis is present in 35% of typical MFS. We report five patients with acute bilateral mydriasis, either isolated or associated with external ophthalmoplegia for which the presumed diagnosis of "atypical MFS" was confirmed by the positivity of anti-GQ1b antibodies. Acute bilateral mydriasis raises important differential diagnoses in clinical practice. This report demonstrates that acute mydriasis can be autoimmune mediated and that anti-GQ1b antibodies are useful to confirm the diagnosis in unexplained cases.
authors.affiliation: Neurology Department, Grenoble University Hospital, Grenoble, France. VFleury@chu-grenoble.fr
authors.forename: V
authors.initials: V
authors.lastname: Fleury
authors.forename: A
authors.initials: A
authors.lastname: Aqallal
authors.forename: E
authors.initials: E
authors.lastname: Lagrange
authors.forename: G
authors.initials: G
authors.lastname: Besson
authors.forename: C
authors.initials: C
authors.lastname: Caudie
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019846:Miller Fisher Syndrome / Q000097:blood / Q000150:complications* / Q000276:immunology; D015878:Mydriasis / Q000209:etiology*; D009886:Ophthalmoplegia / Q000209:etiology
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D005732:Gangliosides; C039129:GQ1b ganglioside