Design strategies for the creation of artificial metalloenzymes.
In recent years, several complementary strategies have been implemented for the creation and optimization of artificial metalloenzymes. Selected examples outline the pros and cons of five different approaches: catalytic antibodies, computational design, directed evolution, artificial metal-cofactors and DNAzymes.
Heinisch
Tillmann
T
Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland.
Ward
Thomas R
TR
D000595:Amino Acid Sequence; D000818:Animals; D032701:Biomimetics / Q000379:methods*; D019295:Computational Biology / Q000379:methods*; D006801:Humans; D008667:Metalloproteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data
D008667:Metalloproteins