title: Prediction of infectious events by high-sensitivity C-reactive protein level before undergoing chemotherapy for acute myeloid leukaemia.
abstract: We retrospectively evaluated the serum high-sensitivity C-reactive protein (CRP) level before chemotherapy for the prediction of infectious events during neutropenia in patients with acute myeloid leukaemia. Thirty-eight patients who underwent first induction chemotherapy and 37 patients who underwent first consolidation chemotherapy were analyzed separately. A receiver-operating characteristic (ROC) curve revealed that the serum CRP level just before the first consolidation chemotherapy, but not just before the induction chemotherapy, had a significant predictive value for febrile neutropenia (FN) at a cut-off value of 0.19 mg/dl and documented infection (DI) at a cut-off value of 0.26 mg/dl. The high-sensitivity CRP measurement enabled the detection of slight increases in the serum CRP level, which might reflect a minute inflammation by occult infection, and discriminated high-risk patients for infectious events.
authors.affiliation: Division of Haematology, Saitama Medical Centre, Jichi Medical University, 1-847 Amanuma, Omiya-ku, Saitama, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Sato
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kako
authors.forename: Kumi
authors.initials: K
authors.lastname: Oshima
authors.forename: Ken
authors.initials: K
authors.lastname: Sato
authors.forename: Kiriko
authors.initials: K
authors.lastname: Terasako
authors.forename: Shun-Ichi
authors.initials: S
authors.lastname: Kimura
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakasone
authors.forename: Shinya
authors.initials: S
authors.lastname: Okuda
authors.forename: Rie
authors.initials: R
authors.lastname: Yamazaki
authors.forename: Takakazu
authors.initials: T
authors.lastname: Higuchi
authors.forename: Junji
authors.initials: J
authors.lastname: Nishida
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kanda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis*; D004358:Drug Therapy; D005260:Female; D005544:Forecasting / Q000379:methods*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000453:epidemiology*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein