[Current situation researching of methylation in tumor].
The disorders of DNA and histone methylation have a close relationship with the development and progression of tumors. Epigenetic regulation is critical in maintaining the stability and integrity of the expression profiles of different cell types by modifying DNA methylation and histone methylation. However, the abnormal changes of methylation often result in the development and progression of tumors. This review summarized the theory of tumor genomic and histone methylation, detection methods of methylation and their applications, and the clinical application of methylation as biological markers and drug targets.
Shao
Di
D
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Beijing 100005, China.
Cui
An-fang
AF
Zhu
Liu-luan
LL
Qiao
Ai-jun
AJ
Kong
Xing-xing
XX
Liu
Xiao-jun
XJ
Chang
Yong-sheng
YS
Fang
Fu-de
FD
D019175:DNA Methylation; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism
D006657:Histones