HuD stimulates translation via eIF4A.
In this issue of Molecular Cell, Fukao et al. (2009) report that HuD upregulates mRNA translation through direct interaction with eIF4A in the 5' cap-binding complex, revealing a posttranscriptional role for HuD in neuronal development and plasticity.
Chen
Chyi-Ying A
CY
Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, 77030, USA.
Shyu
Ann-Bin
AB
D000818:Animals; D002460:Cell Line; D051959:ELAV Proteins / Q000235:genetics / Q000378:metabolism*; D000067779:ELAV-Like Protein 4; D039601:Eukaryotic Initiation Factor-4A / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
D051959:ELAV Proteins; D000067779:ELAV-Like Protein 4; C498010:ELAVL4 protein, human; D012333:RNA, Messenger; D039601:Eukaryotic Initiation Factor-4A