RNA silencing directed against geminiviruses: post-transcriptional and epigenetic components.
It is well-established that plants use cytoplasmic, post-transcriptional gene silencing (PTGS) as a defense against RNA viruses and DNA virus transcripts. More recently, it has become clear that small RNA-directed methylation leading to transcriptional gene silencing (TGS) is also used as a defense against DNA virus chromatin. Here we use the DNA-containing geminiviruses as models to discuss what is currently known about both types of antiviral silencing, and viral suppression of PTGS and TGS as a counterdefense.
Raja
Priya
P
Department of Molecular Genetics and Plant Biotechnology Center, and the Graduate Program in Molecular, Cellular, and Developmental Biology, The Ohio State University, Columbus, OH 43210, USA.
Wolf
Jamie N
JN
Bisaro
David M
DM
D044127:Epigenesis, Genetic; D017791:Geminiviridae / Q000235:genetics*; D018506:Gene Expression Regulation, Plant; D034622:RNA Interference