title: A retrospective comparison of allogeneic peripheral blood stem cell versus bone marrow transplantation.
abstract: OBJECTIVE
  Disease evolution depends in part on the source of transplanted cells. Therefore, we compared outcomes after allogeneic bone marrow (BM) and peripheral blood stem cell (PBSC) transplantation in patients who underwent transplant at Hospital das Clinicas of the Federal University of Minas Gerais, Brazil.
  
  
  METHODS
  We studied 364 patients who received allogeneic BM (n = 142) or PBSC transplantation (n = 222) between July 1995 and May 2005. The median age of the patients was 31 years (range, 3.1-58 years). Chronic myeloid leukemia was the predominant diagnosis (41.2%). A conditioning regimen with cyclosphosphamide and busulfan was used in 79.4% (n = 289) and graft-versus-host disease (GVHD) prophylaxis was cyclosporine/methotrexate in 95.9% (n = 349) of cases.
  
  
  RESULTS
  The patients in the PBSC group had faster neutrophil (P < .001) and platelet engraftment (P = .03) but increased rates of acute GVHD (P < .001) vs. those in the BM group. There was no significant difference between the groups in chronic GVHD, transplant-related mortality, relapse and survival rates.
  
  
  CONCLUSIONS
  Although allogeneic PBSC transplant results in a faster hematopoietic engraftment, there was an increase in acute GVHD. There was no clear benefit in relapse rate and no evidence that transplantation with PBSC benefits patient survival in our institution.
authors.affiliation: Internal Medicine Department, Hematopoietic Stem Cell Transplantation Unit/Hematology Division, Universidade Federal de Minas Gerais, Minas Gerais, Brazil. hebit@terra.com.br
authors.forename: Henrique
authors.initials: H
authors.lastname: Bittencourt
authors.forename: Monalisa
authors.initials: M
authors.lastname: Lopes
authors.forename: Antonio Vaz
authors.initials: AV
authors.lastname: de Macedo
authors.forename: Elen Rose
authors.initials: ER
authors.lastname: Teixeira
authors.forename: Gabriel Gomes Sabido
authors.initials: GG
authors.lastname: Gomes
authors.forename: Galileu Galilei
authors.initials: GG
authors.lastname: Ferreira
authors.forename: Leandro
authors.initials: L
authors.lastname: Amaral
authors.forename: Priscila
authors.initials: P
authors.lastname: Soares
authors.forename: Mônica
authors.initials: M
authors.lastname: Vieira
authors.forename: Luci Maria
authors.initials: LM
authors.lastname: Dusse
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000401:mortality*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology*; D006402:Hematologic Diseases / Q000401:mortality / Q000601:surgery*; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation / Q000401:mortality*; D012189:Retrospective Studies; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous; D055815:Young Adult