Upgrading a natural product: inhibition of human beta-tryptase by cyclotheonamide analogues.
Schaschke
Norbert
N
Fakultät für Chemie, Universität Bielefeld, Universitätsstr. 25, 33615 Bielefeld, Germany. norbert.schaschke@uni-bielefeld.de
Sommerhoff
Christian P
CP
D000818:Animals; D001249:Asthma / Q000188:drug therapy; D002417:Cattle; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology*; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D014357:Trypsin / Q000737:chemistry / Q000378:metabolism; D053802:Tryptases / Q000378:metabolism*
D010456:Peptides, Cyclic; D015842:Serine Proteinase Inhibitors; C452833:cyclotheonamide E4; C081986:cyclotheonamide A; D014357:Trypsin; D053802:Tryptases