title: Modification of vascular and inflammation biomarkers after OGTT in overweight healthy and diabetic subjects.
abstract: We evaluated the effect of an oral glucose tolerance test (OGTT) on the level of biomarkers of vascular remodelling. We enrolled 256 Caucasian overweight healthy subjects (H) and 274 overweight type 2 diabetic patients (D). All patients underwent basal measurements of blood glucose (BG), nitrites/nitrates, adiponectin (ADP), matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-9 (MMP-9) before and after OGTT. Nitrites/nitrates decrease was present after 60, 90, 120, and 180 min in both groups. Nitrite/nitrate levels were decreased at baseline, after 30 and 60 min in D group compared to H group. ADP decrease was present after 90, 120, and 180 min, in both groups. ADP levels were lower in D group than in H group during OGTT. MMP-2 increase was present after 60, 90, and 120 min in H group, while MMP-2 increase was observed after 90, 120, and 180 min in D group. MMP-2 levels were higher in D group than in H group during OGTT. MMP-9 increase was present in H group after 60, 90, 120, and 180 min, while MMP-9 increase was observed after 90, 120, and 180 min in D group. MMP-9 levels were higher in D group than in H group during OGTT. Postprandial glycemia induces an acute increase in biomarkers of vascular remodelling.
authors.affiliation: Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S. Matteo, Pavia, P. le C. Golgi, 2 - 27100 PAVIA, Italy. giuseppe.derosa@unipv.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Derosa
authors.forename: Angela
authors.initials: A
authors.lastname: D'Angelo
authors.forename: Sibilla A T
authors.initials: SA
authors.lastname: Salvadeo
authors.forename: Ilaria
authors.initials: I
authors.lastname: Ferrari
authors.forename: Elena
authors.initials: E
authors.lastname: Fogari
authors.forename: Alessia
authors.initials: A
authors.lastname: Gravina
authors.forename: Roberto
authors.initials: R
authors.lastname: Mereu
authors.forename: Ilaria
authors.initials: I
authors.lastname: Palumbo
authors.forename: Pamela
authors.initials: P
authors.lastname: Maffioli
authors.forename: Sabrina
authors.initials: S
authors.lastname: Randazzo
authors.forename: Arrigo F G
authors.initials: AF
authors.lastname: Cicero
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D050177:Overweight / Q000378:metabolism*; D019518:Postprandial Period
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D009566:Nitrates; D009573:Nitrites; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9