title: Beta-amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia.
abstract: OBJECTIVE
  To investigate whether global and regional beta-amyloid (Abeta) burden as measured with 11C Pittsburgh compound B (PIB) PET is associated with hippocampal atrophy characterized using MRI in healthy controls and patients with amnestic mild cognitive impairment (aMCI) or Alzheimer disease (AD).
  
  
  METHODS
  Ninety-two elderly healthy controls, 32 subjects with aMCI, and 35 patients with AD were imaged using 11C-PIB PET and MRI. Hippocampal volume was measured and PIB standardized uptake value ratio was extracted after partial volume correction within 41 regions of interest. Global, regional, and voxel-based correlations between PIB and hippocampal volume were computed for each group.
  
  
  RESULTS
  In healthy control participants with elevated neocortex PIB retention, significant correlation was found between PIB retention in the inferior temporal region and hippocampal volume using both region-based and voxel-based approaches. No correlation was found in any other group.
  
  
  CONCLUSIONS
  The strong correlation between hippocampal atrophy and beta-amyloid (Abeta) burden in the Pittsburgh compound B-positive healthy control group suggests that Abeta deposition in the inferior temporal neocortex is related to hippocampal synaptic and neuronal degeneration.
authors.affiliation: CSIRO Preventative Health National Research Flagship ICTC, The Australian e-Health Research Centre-BioMedIA, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia. pierrick.bourgeat@csiro.au
authors.forename: P
authors.initials: P
authors.lastname: Bourgeat
authors.forename: G
authors.initials: G
authors.lastname: Chételat
authors.forename: V L
authors.initials: VL
authors.lastname: Villemagne
authors.forename: J
authors.initials: J
authors.lastname: Fripp
authors.forename: P
authors.initials: P
authors.lastname: Raniga
authors.forename: K
authors.initials: K
authors.lastname: Pike
authors.forename: O
authors.initials: O
authors.lastname: Acosta
authors.forename: C
authors.initials: C
authors.lastname: Szoeke
authors.forename: S
authors.initials: S
authors.lastname: Ourselin
authors.forename: D
authors.initials: D
authors.lastname: Ames
authors.forename: K A
authors.initials: KA
authors.lastname: Ellis
authors.forename: R N
authors.initials: RN
authors.lastname: Martins
authors.forename: C L
authors.initials: CL
authors.lastname: Masters
authors.forename: C C
authors.initials: CC
authors.lastname: Rowe
authors.forename: O
authors.initials: O
authors.lastname: Salvado
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism / Q000473:pathology; D000465:Algorithms; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000814:Aniline Compounds; D001284:Atrophy / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D001931:Brain Mapping / Q000379:methods; D002250:Carbon Radioisotopes; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D019579:Neocortex / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D009410:Nerve Degeneration / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D058225:Plaque, Amyloid / Q000378:metabolism / Q000473:pathology*; D049268:Positron-Emission Tomography / Q000379:methods; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D015415:Biomarkers; D002250:Carbon Radioisotopes; D013844:Thiazoles