Widely conserved signaling pathways in the establishment of cell polarity.
How are the asymmetric distributions of proteins, lipids, and RNAs established and maintained in various cell types? Studies from diverse organisms show that Par proteins, GTPases, kinases, and phosphoinositides participate in conserved signaling pathways to establish and maintain cell polarity.
McCaffrey
Luke Martin
LM
Department of Microbiology, Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908-5077, USA.
Macara
Ian G
IG
D000818:Animals; D019070:Cell Lineage; D016764:Cell Polarity; D004330:Drosophila / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D010641:Phenotype; D020033:Protein Isoforms; D012333:RNA, Messenger / Q000378:metabolism; D015398:Signal Transduction
D020033:Protein Isoforms; D012333:RNA, Messenger; D020558:GTP Phosphohydrolases