Drug-drug interactions with the use of psychotropic medications. Interview by Diane M. Sloan.
Drug interactions with psychotropics can result in poor tolerability or reduced efficacy, or both, which can negatively impact patient outcomes. Most drug interactions with psychotropics are pharmacokinetic and involve the CYP family of enzymes. Clinicians can improve outcomes for patients by considering the potential for DDIs when selecting a specific psychotropic, and when evaluating patient progress, compliance, and the incidence of AEs throughout the course of treatment. Resources for clinicians include internet databases, software programs, package inserts, and consultation with pharmacists.
Ereshefsky
Larry
L
California Clinical Trials, PAREXEL International, Glendale, California, USA.
D000428:Alcohol Drinking / Q000009:adverse effects; D001688:Biological Products / Q000009:adverse effects; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects*; D004346:Drug Information Services; D004347:Drug Interactions; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy; D004366:Nonprescription Drugs / Q000009:adverse effects; D011619:Psychotropic Drugs / Q000009:adverse effects* / Q000627:therapeutic use
D001688:Biological Products; D004366:Nonprescription Drugs; D011619:Psychotropic Drugs; D003577:Cytochrome P-450 Enzyme System