Moistening of misoprostol tablets with acetic acid prior to vaginal administration for mid-trimester termination of anomalous pregnancy: A randomised comparison of three regimens.
OBJECTIVE
To compare the efficacy and side effects of three regimens of intravaginal misoprostol for second-trimester abortion.


METHODS
A total of 118 women requiring second-trimester pregnancy termination were randomly assigned to one of three treatment groups: 400 microg 3-hourly in group A (n = 39), 600 microg 6-hourly in group B (n = 39), and 800 microg 12-hourly in group C (n = 40). Misoprostol tablets moistened with 3 ml of 5% acetic acid were placed into the posterior vaginal fornix.


RESULTS
The median induction-abortion times in groups A (8 h [range: 3-64]) and B (9 h [4-81]) were significantly shorter (p < 0.01 and p < 0.05, respectively) than in group C (12.5 [3-72]). Moreover, expulsion rates within 24 hours in groups A (92.3%) and B (92.3%) were significantly higher (p < 0.05 in both cases) than that of group C (75%). Expulsion rate within 48 hours, number of tablets used, number of patients with retained placenta and side effects did not differ between groups.


CONCLUSIONS
Misoprostol moistened with acetic acid is effective for second-trimester pregnancy termination when given vaginally 3-hourly, 6-hourly or 12-hourly. The former two regimens are significantly more effective than the latter.
Yilmaz
Bulent
B
Department of Obstetrics and Gynaecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. drbulentyilmaz@yahoo.com
Ertas
Ibrahim Egemen
IE
Kelekci
Sefa
S
Sut
Necdet
N
Mollamahmutoglu
Leyla
L
Danisman
Nuri
N
D000020:Abortifacient Agents, Nonsteroidal / Q000009:adverse effects; D000028:Abortion, Induced / Q000009:adverse effects / Q000379:methods*; D019342:Acetic Acid; D000282:Administration, Intravaginal; D000328:Adult; D000013:Congenital Abnormalities; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000009:adverse effects; D011247:Pregnancy; D011262:Pregnancy Trimester, Second
D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol; D019342:Acetic Acid