title: Measurement of long-range interatomic distances by solid-state tritium-NMR spectroscopy.
abstract: For the structural determination of a ligand bound to an amorphous macromolecular system, solid-state NMR can be used to provide interatomic distances. It is shown here that selective labeling in discrete locations with tritium enables accurate measurement of long-range distances owing to the high gyromagnetic ratio of this nucleus, without structural modification of the molecule. This approach gives access to the largest NMR distance ever measured between two nuclei (14.4 A). (3)H MAS NMR appears to be a promising tool for structural applications in the biological and material sciences.
authors.affiliation: CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, F-91191 Gif sur Yvette, France.
authors.forename: Alexander K L
authors.initials: AK
authors.lastname: Yuen
authors.forename: Olivier
authors.initials: O
authors.lastname: Lafon
authors.forename: Thibault
authors.initials: T
authors.lastname: Charpentier
authors.forename: Myriam
authors.initials: M
authors.lastname: Roy
authors.forename: Francine
authors.initials: F
authors.lastname: Brunet
authors.forename: Patrick
authors.initials: P
authors.lastname: Berthault
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Sakellariou
authors.forename: Bruno
authors.initials: B
authors.lastname: Robert
authors.forename: Sylvie
authors.initials: S
authors.lastname: Rimsky
authors.forename: Florence
authors.initials: F
authors.lastname: Pillon
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Cintrat
authors.forename: Bernard
authors.initials: B
authors.lastname: Rousseau
mesh_terms: D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D014316:Tritium
chemical_list: D014316:Tritium