[Investigation of oxidative stress-induced alterations in the rat brain cortical cellular culture and their correction with vitamines E and C].
The oxidative stress-induced changes and feasibility of prevention of these changes with an aid of vitamines E and C were investigated in cultured brain cortex of the newborn albino rats. Modeling the oxidative stress was achieved with addition of H(2)O(2) into the nutrient medium. In order to prevent an oxidative stress-induced cytotoxic effect, concomittantly with H(2)O(2), vitamines E and C were added into the nutrient medium. The data, obtained in our study revealed inhibition of the glial cells'- and axonal migration into the growth zone resulting from the oxidative stress. These changes were attenuated following action of vitamines E and C, which points at feasibility of their use against oxidative impact from the free radicals emerging during neurodegenerative disorders.
Davitashvili
D T
DT
Museridze
D P
DP
Svanidze
I K
IK
Gegenava
L G
LG
Sanikidze
T V
TV
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000473:pathology*; D001927:Brain Diseases / Q000188:drug therapy* / Q000473:pathology*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005960:Glucosides / Q000627:therapeutic use*; D057888:Iridoid Glucosides; D039823:Iridoids / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000502:physiology*; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D005960:Glucosides; D057888:Iridoid Glucosides; D039823:Iridoids; D014810:Vitamin E; C078040:catalpol; D001205:Ascorbic Acid