title: Thalamic integrity underlies executive dysfunction in traumatic brain injury.
abstract: OBJECTIVE
  To quantify the effects of traumatic brain injury on integrity of thalamocortical projection fibers and to evaluate whether damage to these fibers accounts for impairments in executive function in chronic traumatic brain injury.
  
  
  METHODS
  High-resolution (voxel size: 0.78 mm x 0.78 mm x 3 mm(3)) diffusion tensor MRI of the thalamus was conducted on 24 patients with a history of single, closed-head traumatic brain injury (TBI) (12 each of mild TBI and moderate to severe TBI) and 12 age- and education-matched controls. Detailed neuropsychological testing with an emphasis on executive function was also conducted. Fractional anisotropy was extracted from 12 regions of interest in cortical and corpus callosum structures and 7 subcortical regions of interest (anterior, ventral anterior, ventral lateral, dorsomedial, ventral posterior lateral, ventral posterior medial, and pulvinar thalamic nuclei).
  
  
  RESULTS
  Relative to controls, patients with a history of brain injury showed reductions in fractional anisotropy in both the anterior and posterior corona radiata, forceps major, the body of the corpus callosum, and fibers identified from seed voxels in the anterior and ventral anterior thalamic nuclei. Fractional anisotropy from cortico-cortico and corpus callosum regions of interest did not account for significant variance in neuropsychological function. However, fractional anisotropy from the thalamic seed voxels did account for variance in executive function, attention, and memory.
  
  
  CONCLUSIONS
  The data provide preliminary evidence that traumatic brain injury and resulting diffuse axonal injury results in damage to the thalamic projection fibers and is of clinical relevance to cognition.
authors.affiliation: Departments of Neurology, Center for Stroke Research, The University of Illinois Medical Center at Chicago, Chicago, IL, USA. little@uic.edu
authors.forename: D M
authors.initials: DM
authors.lastname: Little
authors.forename: M F
authors.initials: MF
authors.lastname: Kraus
authors.forename: J
authors.initials: J
authors.lastname: Joseph
authors.forename: E K
authors.initials: EK
authors.lastname: Geary
authors.forename: T
authors.initials: T
authors.lastname: Susmaras
authors.forename: X J
authors.initials: XJ
authors.lastname: Zhou
authors.forename: N
authors.initials: N
authors.lastname: Pliskin
authors.forename: P B
authors.initials: PB
authors.lastname: Gorelick
mesh_terms: D000293:Adolescent; D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000473:pathology; D001930:Brain Injuries / Q000473:pathology*; D003072:Cognition Disorders / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D056344:Executive Function; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009434:Neural Pathways / Q000473:pathology; D009483:Neuropsychological Tests; D013788:Thalamus / Q000473:pathology*; D055815:Young Adult