title: Chronic non-transmural infarction has a delayed recovery of function following revascularization.
abstract: BACKGROUND
  The time course of regional functional recovery following revascularization with regards to the presence or absence of infarction is poorly known. We studied the effect of the presence of chronic non-transmural infarction on the time course of recovery of myocardial perfusion and function after elective revascularization.
  
  
  METHODS
  Eighteen patients (mean age 69, range 52-84, 17 men) prospectively underwent cine magnetic resonance imaging (MRI), delayed contrast enhanced MRI and rest/stress 99m-Tc-tetrofosmin single photon emission computed tomography (SPECT) before, one and six months after elective coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI).
  
  
  RESULTS
  Dysfunctional myocardial segments (n = 337/864, 39%) were classified according to the presence (n = 164) or absence (n = 173) of infarction. Infarct transmurality in dysfunctional segments was largely non-transmural (transmurality = 31 +/- 22%). Quantitative stress perfusion and wall thickening increased at one month in dysfunctional segments without infarction (p < 0.001), with no further improvement at six months. Despite improvements in stress perfusion at one month (p < 0.001), non-transmural infarction displayed a slower and lesser improvement in wall thickening at one (p < 0.05) and six months (p < 0.001).
  
  
  CONCLUSIONS
  Dysfunctional segments without infarction represent repetitively stunned or hibernating myocardium, and these segments improved both perfusion and function within one month after revascularization with no improvement thereafter. Although dysfunctional segments with non-transmural infarction improved in perfusion at one month, functional recovery was mostly seen between one and six months, possibly reflecting a more severe ischemic burden. These findings may be of value in the clinical assessment of regional functional recovery in the time period after revascularization.
authors.affiliation: Department of Clinical Physiology, Lund University Hospital, Lund University, Lund, SE-221 85 Sweden.
authors.forename: Martin
authors.initials: M
authors.lastname: Ugander
authors.forename: Peter A
authors.initials: PA
authors.lastname: Cain
authors.forename: Per
authors.initials: P
authors.lastname: Johnsson
authors.forename: John
authors.initials: J
authors.lastname: Palmer
authors.forename: Håkan
authors.initials: H
authors.lastname: Arheden
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D002908:Chronic Disease; D001026:Coronary Artery Bypass / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology* / Q000628:therapy*; D009204:Myocardial Revascularization / Q000379:methods; D011446:Prospective Studies; D020127:Recovery of Function / Q000502:physiology*; D013997:Time Factors