The role of ultraviolet radiation in melanomagenesis.
The role of ultraviolet radiation (UV) in the pathogenesis has been discussed controversially for many decades. Studies in mice (SCID, HGF/SF, SV40T) which develop malignant melanoma, show a role of UVB in melanomagenesis. In contrast to this, the role of UVA is less clear. We will review the recent in vitro and in vivo data in support of the hypothesis that UVA is also involved in the development of malignant melanoma. The role of UVA in p53 activation, apoptosis, cell cycle arrest and photoproduct formation is discussed.
von Thaler
Anna-Katharina
AK
Department of Dermatology, Eberhard Karls University, Tübingen, Germany.
Kamenisch
York
Y
Berneburg
Mark
M
D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D004249:DNA Damage; D004195:Disease Models, Animal; D006801:Humans; D008545:Melanoma / Q000209:etiology* / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D018384:Oxidative Stress; D012878:Skin Neoplasms / Q000209:etiology* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014466:Ultraviolet Rays / Q000009:adverse effects*
D016159:Tumor Suppressor Protein p53