sP-selectin in preeclamptic pregnancies with intrauterine normal growth and small-for-gestational-age foetus. Preliminary communication.
OBJECTIVE
The aim of this study was the comparative analysis of the sP-selectin in pregnancies complicated by severe preeclampsia with intrauterine normal growth and small-for-gestational-age foetus.


METHODS
The study was carried out on 14 patients with preeclampsia complicated by intrauterine growth retardation (group PI) and 13 preeclamptic patients with appropriate-for-gestational-age weight infants (group P). The control group consisted of 13 healthy normotensive pregnant patients with singleton uncomplicated pregnancies (group C). Maternal serum soluble P-selectin concentrations were estimated using sandwich ELISA assay according to the manufacturer's instructions.


RESULTS
Pregnant women with severe preeclampsia had higher maternal serum sP-selectin levels than the normotensive controls. The sP-selectin levels were highest and statistically significant in preeclamptic patients with appropriate-for-gestational-age weight infants.


CONCLUSIONS
Our findings indicate an association between the increased levels of sP-selectin and severe preeclampsia. However, further studies are required to validate this association and explore the possibility of clinical importance and causative role of sP-selectin in the pathogenesis of preeclampsia.
Laskowska
Marzena
M
Department of Obstetrics and Perinatology Medical University of Lublin, ul. Jaczewskiego 8, 20-950 Lublin. melaskowska@go2.pl
Laskowska
Katarzyna
K
Leszczyńska-Gorzelak
Bozena
B
Oleszczuk
Jan
J
D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood*; D019007:P-Selectin / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012016:Reference Values
D015415:Biomarkers; D019007:P-Selectin