CALHM1 P86L polymorphism is a risk factor for Alzheimer's disease in the Chinese population.
We conducted a case-control study to determine the prevalence of the CALHM1 P86L polymorphism (rs2986017) in patients with Alzheimer's disease (AD) in the Chinese population of mainland China, and also to clarify whether this polymorphism is a risk factor for AD. Fourteen heterozygous P86L carriers were identified among 198 AD patients. One control subject was also found to be a P86L heterozygous carrier. The allelic frequencies of the AD patients and control subjects were found to be significantly different. Our study indicates that the CALHM1-P86L polymorphism is associated with AD in the ethnic Chinese Han.
Cui
Pei-Jing
PJ
Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zheng
Lan
L
Cao
Li
L
Wang
Ying
Y
Deng
Yu-Lei
YL
Wang
Gang
G
Xu
Wei
W
Tang
Hui-Dong
HD
Ma
Jian-Fang
JF
Zhang
Ting
T
Ding
Jian-Qing
JQ
Cheng
Qi
Q
Chen
Sheng-Di
SD
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D044466:Asian People / Q000235:genetics*; D015220:Calcium Channels / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D006801:Humans; D007930:Leucine / Q000235:genetics; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011392:Proline / Q000235:genetics; D012307:Risk Factors
C530077:CALHM1 protein, human; D015220:Calcium Channels; D008562:Membrane Glycoproteins; D011392:Proline; D007930:Leucine