title: Future requirement for arterial wall imaging modalities in the evaluation of novel anti-atherosclerotic therapies.
abstract: BACKGROUND
  While arterial wall imaging has been used to characterize progression of atherosclerosis, there remain limitations to this approach.
  
  
  METHODS
  A selective overview of emerging modalities to image the artery wall and highlight how they may be used to evaluate emerging anti-atherosclerotic agents.
  
  
  RESULTS
  Ongoing developments appear to enable assessment of composition and molecular properties of plaque in addition to quantitation of burden. Non-invasiveness and correlation with clinical outcome remains a challenge.
  
  
  CONCLUSIONS
  New developments in imaging should enhance the ability to provide early characterization of the potential therapeutic efficacy of experimental agents.
authors.affiliation: Cleveland Clinic, Cleveland OH, USA.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Bayturan
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Uno
authors.forename: Andrea
authors.initials: A
authors.lastname: Lavoie
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Nicholls
mesh_terms: D000792:Angiography / Q000379:methods / Q000639:trends; D001158:Arteries; D050197:Atherosclerosis / Q000000981:diagnostic imaging* / Q000628:therapy*; D006801:Humans; D008991:Monitoring, Physiologic / Q000379:methods* / Q000639:trends*