title: A relationship between Alzheimer's disease and type 2 diabetes mellitus through the measurement of serum amyloid-beta autoantibodies.
abstract: Increasing evidence suggests that type 2 diabetes mellitus (T2DM) is strongly correlated with Alzheimer's disease (AD). To examine the relationship between T2DM and AD, autoantibodies against amyloid-Abeta were measured in the serum of T2DM patients and age-matched controls. Levels of Abeta autoantibody were measured by ELISA in serum samples of T2DM patients (n=92) and age-matched control group (n=106). Abeta autoantibody levels were increased in T2DM compared with age-matched controls by 45.4 +/- 8.1% (p< 0.001). Females had higher Abeta autoantibody levels than males in both T2DM and control group. Abeta autoantibody levels in the T2DM group were positively correlated with the levels of cholesterol (p=0.011), low density lipoprotein cholesterol (p=0.020), and triglycerides (p=0.039). In conclusion, the level of Abeta autoantibody is dramatically elevated in patient serum of T2DM, and, as such, might be used as a possible biomarker for T2DM.
authors.affiliation: Department of Biochemistry & Biomedical Sciences, Seoul, Korea.
authors.forename: Insub
authors.initials: I
authors.lastname: Kim
authors.forename: Junhee
authors.initials: J
authors.lastname: Lee
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Hong
authors.forename: Eun Sun
authors.initials: ES
authors.lastname: Jung
authors.forename: Yun Hyi
authors.initials: YH
authors.lastname: Ku
authors.forename: In Kyong
authors.initials: IK
authors.lastname: Jeong
authors.forename: Young Min
authors.initials: YM
authors.lastname: Cho
authors.forename: Insuk
authors.initials: I
authors.lastname: So
authors.forename: Kyong Soo
authors.initials: KS
authors.lastname: Park
authors.forename: Inhee
authors.initials: I
authors.lastname: Mook-Jung
mesh_terms: D000544:Alzheimer Disease / Q000097:blood* / Q000453:epidemiology*; D016229:Amyloid beta-Peptides / Q000097:blood* / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D016229:Amyloid beta-Peptides; D001323:Autoantibodies; D007074:Immunoglobulin G