title: Arsonoliposomes: preparation and physicochemical characterization.
abstract: Arsonoliposomes (ARSL) which are liposomes that contain arsonolipids in their membranes have shown interesting anticancer and antiparasitic activity in vitro. Their lipid composition (the specific arsonolipids and/or phospholipids used for their preparation, and the relative amounts of each lipid type) highly influences their physicochemical properties as well as their in vivo kinetics and antiparasitic activity; however, their cytotoxicity towards cancer cells is minimally--if at all--modified. ARSL are prepared by a modification of the "one step" method followed or not by sonication (for formation of sonicated or non-sonicated ARSL, respectively). Arsonoliposomes may be composed only of arsonolipids (containing or not cholesterol) [plain ARSL], or they may contain mixtures of arsonolipids with phospholipids (with or without Chol) [mixed ARSL]. Herein, we describe in detail the preparation and physicochemical characterization of ARSL.
authors.affiliation: Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, and FORTH-Institute of Chemical Engineering, Patras, Greece.
authors.forename: Sophia G
authors.initials: SG
authors.lastname: Antimisiaris
authors.forename: Panayiotis V
authors.initials: PV
authors.lastname: Ioannou
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D000977:Antiparasitic Agents / Q000737:chemistry*; D001151:Arsenic / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D000977:Antiparasitic Agents; D008055:Lipids; D008081:Liposomes; D001151:Arsenic