[Superficial acral fibromyxoma of finger: report of a case with review of literature].
OBJECTIVE
To study the clinicopathologic characteristics, immunophenotype and differential diagnosis of superficial acral fibromyxoma (SAF).


METHODS
The clinical, pathologic and immunohistochemical features of a case of SAF occurring in left middle finger was studied, with review of literature.


RESULTS
The patient was a 62-year-old male who presented with a solitary painful nodule located in the distal aspect of his left middle finger. The nodule lied close to the nail bed and deep to the underlying periosteum. Grossly, the tumor was poorly circumscribed, measured 2 cm in greatest dimension and had a greyish-white cut surface and rubbery consistency. On low-power examination, the tumor was centred in the dermis and displayed a vague lobular pattern. The tumor cells were spindled to stellate in shape and associated with myxoid matrix. Focal fascicular or loose storiform patterns were also noted. A delicate vascular network was identified in the myxoid stroma. Mast cells were readily observed. On high-power examination, the tumor cells were relatively bland-looking and showed at most a mild degree of nuclear atypia. Mitotic figures were rare and coagulative tumor necrosis was absent. Immunohistochemical study showed that the tumor cells were positive for vimentin, CD34 and CD99. Focal staining for CD10 was also demonstrated. Other immunomarkers including actins, desmin and epithelial membrane antigen were negative.


CONCLUSIONS
SAF is a distinctive soft tissue tumor occurring mainly in the digits of adults. Awareness of this entity is helpful in distinguishing SAF from other myxoid soft tissue tumors occurring there. Complete excision with clear resection margins is the mainstay of treatment.
Wang
Qi-Feng
QF
Department of Pathology, No. 4 Hospital, Wuxi 214062, China.
Pu
Yong
Y
Wu
Yu-Yu
YY
Wang
Jia
J
D000071443:12E7 Antigen; D015703:Antigens, CD / Q000378:metabolism; D018952:Antigens, CD34 / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D018223:Dermatofibrosarcoma / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005350:Fibroma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005385:Fingers / Q000473:pathology*; D005500:Follow-Up Studies; D045888:Ganglion Cysts / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018317:Nerve Sheath Neoplasms / Q000378:metabolism / Q000473:pathology; D011859:Radiography; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D014746:Vimentin / Q000378:metabolism
D000071443:12E7 Antigen; D015703:Antigens, CD; D018952:Antigens, CD34; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D014746:Vimentin