title: A prospective study of risk factor profile & incidence of deep venous thrombosis among medically-ill hospitalized patients at a tertiary care hospital in northern India.
abstract: OBJECTIVE
  Hospitalization for medical-illness is associated with an increased risk of deep venous thrombosis (DVT). However, there are no published data from India addressing at this issue. We sought to study the risk factor profile and the incidence of DVT among hospitalized medically-ill patients, a tertiary care hospital in northern India.
  
  
  METHODS
  All adults admitted to the medical wards and intensive care unit with level 1 or 2 mobility over a period of two years (July 2006 to July 2008) at the All India Institute of Medical Sciences hospital, New Delhi, were prospectively studied. Patients having DVT at admission or an anticipated hospital stay less than 48 h were excluded. The presence of clinical risk factors for DVT was recorded and laboratory evaluation was done for hypercoagulable state. A routine surveillance venous compression Doppler ultrasonography was performed 12 +/- 8 days after hospital admission.
  
  
  RESULTS
  Of the 163 patients, 77 (47%) had more than one risk factor for DVT. Five (3%) patients developed DVT; none of them had symptomatic DVT. None of these patients received anticoagulation prior to the development of DVT. The mean age of those who developed DVT was 40 +/- 13 (25-50) yr; two of five were male. The incidence rate of DVT was 2.7 per 1000 person-days of hospital stay [95% confidence interval (CI): 0.87 to 6.27]. None of the factors was found to be significantly associated with the risk of DVT.
  
  
  CONCLUSIONS
  In our setting, although many hospitalized medically-ill patients had risk factors for DVT, the absolute risk of DVT was low compared to the western population but clearly elevated compared to non hospitalized patients. Large studies from India are required to confirm our findings.
authors.affiliation: Division of Pulmonary, Critical Care & Sleep Medicine, Head, Department of Medicine All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India. sksharma@aiims.ac.in
authors.forename: Surendra K
authors.initials: SK
authors.lastname: Sharma
authors.forename: Varun
authors.initials: V
authors.lastname: Gupta
authors.forename: Tamilarasu
authors.initials: T
authors.lastname: Kadhiravan
authors.forename: Amit
authors.initials: A
authors.lastname: Banga
authors.forename: Ashu
authors.initials: A
authors.lastname: Seith
authors.forename: Atin
authors.initials: A
authors.lastname: Kumar
authors.forename: Renu
authors.initials: R
authors.lastname: Saxena
authors.forename: Molly M
authors.initials: MM
authors.lastname: Thabah
authors.forename: Vandana
authors.initials: V
authors.lastname: Gulati
authors.forename: Indrish
authors.initials: I
authors.lastname: Bhatia
authors.forename: Amit A
authors.initials: AA
authors.lastname: Kavimandan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006760:Hospitalization; D006801:Humans; D007194:India / Q000453:epidemiology; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D020246:Venous Thrombosis / Q000453:epidemiology* / Q000209:etiology; D055815:Young Adult