Euphane triterpenoids of Cassipourea lanceolata from the Madagascar rainforest.
Fractionation of an ethanol extract of a Madagascar collection of the leaves and fruit of Cassipourea lanceolata Tul. led to the isolation of three euphane triterpenoids 1-3. The (1)H and (13)C NMR spectra of all compounds were fully assigned using a combination of 2D NMR experiments, including COSY, TOCSY, HSQC (HMQC), HMBC and ROESY sequences. The three compounds showed weak antiproliferative activities against the A2780 human ovarian cancer cell line, with IC(50) values of 25, 25 and 32 microM, respectively.
Hou
Yanpeng
Y
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0212, USA.
Cao
Shugeng
S
Brodie
Peggy J
PJ
Miller
James S
JS
Birkinshaw
Chris
C
Andrianjafy
Mamisoa N
MN
Andriantsiferana
Rabodo
R
Rasamison
Vincent E
VE
TenDyke
Karen
K
Shen
Yongchun
Y
Suh
Edward M
EM
Kingston
David G I
DG
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D005260:Female; D005638:Fruit; D006801:Humans; D020128:Inhibitory Concentration 50; D008270:Madagascar; D015394:Molecular Structure; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018515:Plant Leaves; D043982:Rhizophoraceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014315:Triterpenes; C552300:dihydroxy-8,24E-euphadien-11-one; C552299:tetrahydroxy-7,24E-euphadiene