title: A complex karyotype including a t(2;11) in a paediatric ependymoma: case report and review of the literature.
abstract: Ependymomas are glial tumours representing approximately 5-10% of all intracranial tumours and are the third most common primary brain tumour in childhood. Only a few karyotypic studies on paediatric ependymomas have been published and no specific chromosomal aberration has been specifically related to this type of cancer. We performed cytogenetic analysis of an ependymoma in an 11-year-old boy. Our patient showed a complex karyotype, characterized by a near-tetraploidy and a sole structural unbalanced aberration: der(2)t(2;11)(q11.2;q13.1), which has not been described before. We here discuss such cytogenetic findings, comparing our data with those reported in the literature.
authors.affiliation: Department of Paediatric Haematology/Oncology, University of Turin, Piazza Polonia, 94, 10126 Torino, Italy. simona.aschero@unito.it
authors.forename: Simona
authors.initials: S
authors.lastname: Aschero
authors.forename: Stefano
authors.initials: S
authors.lastname: Vallero
authors.forename: Isabella
authors.initials: I
authors.lastname: Morra
authors.forename: Luciana
authors.initials: L
authors.lastname: Impera
authors.forename: Marco
authors.initials: M
authors.lastname: Forni
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sandri
authors.forename: Maria E
authors.initials: ME
authors.lastname: Basso
authors.forename: Clelia T
authors.initials: CT
authors.lastname: Storlazzi
authors.forename: Flavio
authors.initials: F
authors.lastname: Giordano
authors.forename: Paola
authors.initials: P
authors.lastname: Fidani
authors.forename: Maria A
authors.initials: MA
authors.lastname: De Ioris
authors.forename: Luca Cordero
authors.initials: LC
authors.lastname: di Montezemolo
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D002648:Child; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D004806:Ependymoma / Q000235:genetics*; D006801:Humans; D007621:Karyotyping / Q000379:methods*; D008297:Male; D014178:Translocation, Genetic