title: Efficacy of antibiotic-impregnated external ventricular drain catheters.
abstract: We prospectively compared the incidence of ventriculitis associated with external ventricular drains (EVD) impregnated with clindamycin and rifampicin with historical controls. We found the use of antibiotic impregnated (AI) EVDs showed a significant decrease in positive cerebrospinal fluid cultures and a significant delay in time to EVD infection.
authors.affiliation: Department of Microbiology, Auckland City Hospital, Private Bag 92024, Grafton, Auckland 1023, New Zealand.
authors.forename: S
authors.initials: S
authors.lastname: Muttaiyah
authors.forename: S
authors.initials: S
authors.lastname: Ritchie
authors.forename: S
authors.initials: S
authors.lastname: John
authors.forename: E
authors.initials: E
authors.lastname: Mee
authors.forename: S
authors.initials: S
authors.lastname: Roberts
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis; D002408:Catheters, Indwelling / Q000009:adverse effects* / Q000382:microbiology; D002494:Central Nervous System Infections / Q000134:cerebrospinal fluid / Q000209:etiology / Q000601:surgery; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects* / Q000379:methods; D002648:Child; D002675:Child, Preschool; D002981:Clindamycin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019586:Intracranial Hypertension / Q000209:etiology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012293:Rifampin / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D002981:Clindamycin; D012293:Rifampin