title: Unprecedented synthesis of a novel amino quinone ring system via oxidative decarboxylation of quinone-based alpha,alpha-amino esters.
abstract: An unusual and efficient method for the synthesis of new quinone-based amine and its derivatives from the corresponding alpha,alpha-amino ester is described. The procedure involves the quinone-based system's oxidative decarboxylation via hydride transfer throughout basic hydrolysis. This synthetic method provides, with good yields, rapid access to new potentially cytotoxic quinones.
authors.affiliation: Department of Pharmaceutical Science, University of Salerno, I-84084, Fisciano, Salerno, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Campiglia
authors.forename: Claudio
authors.initials: C
authors.lastname: Aquino
authors.forename: Alessia
authors.initials: A
authors.lastname: Bertamino
authors.forename: Nicoletta
authors.initials: N
authors.lastname: De Simone
authors.forename: Marina
authors.initials: M
authors.lastname: Sala
authors.forename: Sabrina
authors.initials: S
authors.lastname: Castellano
authors.forename: Marisabella
authors.initials: M
authors.lastname: Santoriello
authors.forename: Paolo
authors.initials: P
authors.lastname: Grieco
authors.forename: Ettore
authors.initials: E
authors.lastname: Novellino
authors.forename: Isabel M
authors.initials: IM
authors.lastname: Gomez-Monterrey
mesh_terms: D000588:Amines / Q000737:chemistry; D016227:Benzoquinones / Q000138:chemical synthesis* / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D006868:Hydrolysis; D010084:Oxidation-Reduction
chemical_list: D000588:Amines; D016227:Benzoquinones; D002264:Carboxylic Acids; D004952:Esters; C004532:quinone