Modulation of apoptosis against P. falciparum by low dose radiation in human PBMCs.
BACKGROUND
Implications of low dose radiation (LDR) have been well reported in cancer therapy but data is scanty on the therapeutic application of LDR in infectious diseases.


METHODS
Human peripheral blood mononuclear cells (PBMCs) were cultured and exposed to 0.07 Gy. P. falciparum infected RBCs were mixed with the PBMCs after five hours of irradiation. Thereafter, PBMCs were monitored for micronuclei and apoptosis.


RESULTS
The low dose pre-irradiated PBMCs which were subsequently challenged with parasite, showed a reduction in micronuclei frequency and apoptosis as compared to controls.


CONCLUSIONS
LDR inhibited apoptosis against P. falciparum in human PBMCs.
Singh
Sompal
S
Radiation Biosciences, Institute of Nuclear Medicine & Allied Sciences (DRDO), Delhi, India. somuatar@gmail.com
Dhiman
Ramesh C
RC
Dash
Aditya P
AP
D000328:Adult; D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D002478:Cells, Cultured; D005720:Gamma Rays; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000469:parasitology* / Q000528:radiation effects*; D010963:Plasmodium falciparum / Q000254:growth & development* / Q000528:radiation effects*; D055815:Young Adult