title: Interaction of methylenetetrahydrofolate reductase genotype and smoking habit in Taiwanese lung cancer patients.
abstract: The aim of this study was to evaluate the association and interaction of genotypic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and environmental factors with lung cancer in Taiwan. Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed in association with lung cancer susceptibility, and discussed their joint effects with individual habits on lung cancer risk.
  
  
  METHODS
  In total, 358 patients with lung cancer and 716 healthy controls recruited from the China Medical Hospital in central Taiwan were genotyped.
  
  
  RESULTS
  The MTHFR C677T genotype, but not the A1298C, was differently distributed between the lung cancer and control groups. The T allele of MTHFR C677T was significantly more frequently found in controls than in cancer patients. As for A1298C polymorphism, there was no difference in distribution between the lung cancer and control groups. Gene interactions with smoking were significant for MTHFR C677T polymorphism. The MTHFR C677T CT and TT genotypes in association with smoking conferred a decreased risk of 0.706 (95% confidence interval=0.531-0.939) for lung cancer.
  
  
  CONCLUSIONS
  Our results provide the first evidence that the C allele of MTHFR C677T may be associated with the development of lung cancer and may be a novel useful marker for primary prevention and anticancer intervention.
authors.affiliation: Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Chiu-Shong
authors.initials: CS
authors.lastname: Liu
authors.forename: Chia-Wen
authors.initials: CW
authors.lastname: Tsai
authors.forename: Te-Chun
authors.initials: TC
authors.lastname: Hsia
authors.forename: Rou-Fen
authors.initials: RF
authors.lastname: Wang
authors.forename: Chin-Jung
authors.initials: CJ
authors.lastname: Liu
authors.forename: Liang-Wen
authors.initials: LW
authors.lastname: Hang
authors.forename: Su-Yin
authors.initials: SY
authors.lastname: Chiang
authors.forename: Chung-Hsing
authors.initials: CH
authors.lastname: Wang
authors.forename: Ru-Yin
authors.initials: RY
authors.lastname: Tsai
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Lin
authors.forename: Da-Tian
authors.initials: DT
authors.lastname: Bau
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D013624:Taiwan / Q000453:epidemiology
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)