title: Chi-square-based scoring function for categorization of MEDLINE citations.
abstract: OBJECTIVE
  Text categorization has been used in biomedical informatics for identifying documents containing relevant topics of interest. We developed a simple method that uses a chi-square-based scoring function to determine the likelihood of MEDLINE citations containing genetic relevant topic.
  
  
  METHODS
  Our procedure requires construction of a genetic and a nongenetic domain document corpus. We used MeSH descriptors assigned to MEDLINE citations for this categorization task. We compared frequencies of MeSH descriptors between two corpora applying chi-square test. A MeSH descriptor was considered to be a positive indicator if its relative observed frequency in the genetic domain corpus was greater than its relative observed frequency in the nongenetic domain corpus. The output of the proposed method is a list of scores for all the citations, with the highest score given to those citations containing MeSH descriptors typical for the genetic domain.
  
  
  RESULTS
  Validation was done on a set of 734 manually annotated MEDLINE citations. It achieved predictive accuracy of 0.87 with 0.69 recall and 0.64 precision. We evaluated the method by comparing it to three machine-learning algorithms (support vector machines, decision trees, naïve Bayes). Although the differences were not statistically significantly different, results showed that our chi-square scoring performs as good as compared machine-learning algorithms.
  
  
  CONCLUSIONS
  We suggest that the chi-square scoring is an effective solution to help categorize MEDLINE citations. The algorithm is implemented in the BITOLA literature-based discovery support system as a preprocessor for gene symbol disambiguation process.
authors.affiliation: Institute of Medical Genetics, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: A
authors.initials: A
authors.lastname: Kastrin
authors.forename: B
authors.initials: B
authors.lastname: Peterlin
authors.forename: D
authors.initials: D
authors.lastname: Hristovski
mesh_terms: D022126:Access to Information; D000465:Algorithms; D001185:Artificial Intelligence; D001499:Bayes Theorem; D016009:Chi-Square Distribution; D003625:Data Collection; D003627:Data Interpretation, Statistical; D057225:Data Mining; D004282:Documentation / Q000379:methods*; D006801:Humans; D016239:MEDLINE; D008490:Medical Informatics; D009323:Natural Language Processing