title: Diurnal cortisol levels, psychiatric symptoms and sense of coherence in abused adolescents.
abstract: BACKGROUND
  The role of the hypothalamic-pituitary-adrenal (HPA) axis in psychiatric disorders following trauma is poorly studied and most studies have been done on adults.
  
  
  OBJECTIVE
  To investigate the association of mental well-being and diurnal cortisol in abused adolescents.
  
  
  METHODS
  The present cross-sectional study examined diurnal salivary cortisol (measured three times a day during three days) in relation to psychiatric symptoms (Trauma Symptoms Checklist for Children) and the salutogenic construct "sense of coherence", in 15 adolescents exposed to childhood abuse.
  
  
  RESULTS
  Significant correlations were found between symptoms and sense of coherence versus early and late morning cortisol concentrations. The correlations were most consistent for internalizing and externalizing symptoms, and somewhat less for post-traumatic symptoms and sense of coherence. In contrast, evening cortisol did not correlate with any of the psychological measures.
  
  
  CONCLUSIONS
  These results extend previous research findings by pointing towards a relation between symptoms and higher morning cortisol and accentuated diurnal cortisol variation in abused adolescent as opposed to lower basal cortisol and a flattening of the cortisol rhythm repeatedly observed in traumatized adults.
  
  
  CONCLUSIONS
  The pathophysiology of the impact of trauma on youth, including the impact on biological stress systems, are important for an understanding of the consequences of trauma and may serve as a basis for the development of new treatment options.
authors.affiliation: Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, SE-901 85 Umeå, Sweden. Per.E.Gustafsson@fammed.umu.se
authors.forename: Per E
authors.initials: PE
authors.lastname: Gustafsson
authors.forename: Nina
authors.initials: N
authors.lastname: Nelson
authors.forename: Per A
authors.initials: PA
authors.lastname: Gustafsson
mesh_terms: D000293:Adolescent; D002648:Child; D002649:Child Abuse / Q000523:psychology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D010913:Pituitary-Adrenal System / Q000378:metabolism / Q000503:physiopathology; D012463:Saliva / Q000737:chemistry; D012649:Self Concept; D013313:Stress Disorders, Post-Traumatic / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D011795:Surveys and Questionnaires
chemical_list: D006854:Hydrocortisone