title: Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke: a possible linkage to homocysteine.
abstract: OBJECTIVE
  Homocysteine (Hcy) is an independent predictor of stroke. Coupling factor 6 (CF6) is regulated by nuclear factor kappa B (NF-kappaB) signaling which is activated by Hcy. We tested the hypothesis that CF6 is elevated with Hcy in stroke. We also examined the effect of vitamin treatment on CF6 and Hcy levels.
  
  
  RESULTS
  The 59 Japanese patients with a recent history of stroke were randomly assigned to a group without vitamin treatment (Group 1, n = 29) and to a group with treatment with both folic acid and vitamin B(12) for 2 months (Group 2, n = 30). The CF6 level was elevated in the patients with stroke compared with that in controls (n = 64) at admission. In a multiple regression model, the plasma CF6 level was weakly correlated to the total Hcy (tHcy) level. In Group 1, the plasma tHcy and CF6 levels were unchanged. In Group 2, however, they were both decreased, and there was a weak positive correlation between the decreases in plasma levels of CF6 and tHcy.
  
  
  CONCLUSIONS
  CF6 is elevated in patients with stroke independently of risk factors. Since Hcy and vitamin treatment affect CF6 levels in stroke, CF6 appears to be a novel molecule for the pathogenesis and treatment of stroke.
authors.affiliation: Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. osanait@cc.hirosaki-u.ac.jp
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Osanai
authors.forename: Naoto
authors.initials: N
authors.lastname: Fujiwara
authors.forename: Satoko
authors.initials: S
authors.lastname: Sasaki
authors.forename: Norifumi
authors.initials: N
authors.lastname: Metoki
authors.forename: Genta
authors.initials: G
authors.lastname: Saitoh
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tomita
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishimura
authors.forename: Shuji
authors.initials: S
authors.lastname: Shibutani
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yokoyama
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Konta
authors.forename: Koji
authors.initials: K
authors.lastname: Magota
authors.forename: Ken
authors.initials: K
authors.lastname: Okumura
mesh_terms: D000368:Aged; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D025261:Mitochondrial Proton-Translocating ATPases / Q000097:blood*; D010086:Oxidative Phosphorylation Coupling Factors / Q000097:blood*; D020521:Stroke / Q000097:blood / Q000188:drug therapy*; D014805:Vitamin B 12 / Q000627:therapeutic use*; D014803:Vitamin B Complex / Q000627:therapeutic use*
chemical_list: D010086:Oxidative Phosphorylation Coupling Factors; D006710:Homocysteine; D014803:Vitamin B Complex; D005492:Folic Acid; C000628217:F(6) ATPase; D025261:Mitochondrial Proton-Translocating ATPases; D014805:Vitamin B 12