title: Application of bone morphogenetic proteins to femoral non-unions: a 4-year multicentre experience.
abstract: Fracture non-unions often complicate orthopaedic trauma. BMPs (bone morphogenetic proteins) are currently considered the most appealing osteoinductive agents. Applications of BMP-7 since January 2004 were prospectively recorded in a multicentre registry of aseptic femoral non-unions. The study included 30 patients who had undergone a median of 1 revision operation before BMP-7 application and who were followed up for a median 24 months. In 23/30 cases the application of BMP-7 was combined with revision of the fixation, and in 12 it was combined also with autograft. Non-union healing was verified in 26/30 cases in a median period of 6 months. No adverse events were associated with BMP-7 application. Our case series supports the safety and efficacy of BMP-7 in femoral non-unions. Multicentre networks and systematic, long-term follow-up of patients may improve understanding of this promising osteoinductive bone substitute.
authors.affiliation: Department of Trauma and Orthopaedics, Leeds Teaching Hospitals NHS Trust, Leeds General Infirmary, Leeds LS1 3EX, UK.
authors.forename: N K
authors.initials: NK
authors.lastname: Kanakaris
authors.forename: N
authors.initials: N
authors.lastname: Lasanianos
authors.forename: G M
authors.initials: GM
authors.lastname: Calori
authors.forename: R
authors.initials: R
authors.lastname: Verdonk
authors.forename: T J
authors.initials: TJ
authors.lastname: Blokhuis
authors.forename: P
authors.initials: P
authors.lastname: Cherubino
authors.forename: P
authors.initials: P
authors.lastname: De Biase
authors.forename: P V
authors.initials: PV
authors.lastname: Giannoudis
mesh_terms: D000328:Adult; D000368:Aged; D055419:Bone Morphogenetic Protein 7 / Q000008:administration & dosage / Q000627:therapeutic use*; D004337:Drug Carriers; D005260:Female; D005264:Femoral Fractures / Q000000981:diagnostic imaging / Q000628:therapy*; D005500:Follow-Up Studies; D005592:Fracture Fixation / Q000379:methods*; D017102:Fracture Healing / Q000187:drug effects*; D005599:Fractures, Ununited / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012042:Registries; D012086:Reoperation; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D055419:Bone Morphogenetic Protein 7; D004337:Drug Carriers