title: Circulating vascular progenitor cells in patients with type 1 diabetes and microalbuminuria.
abstract: OBJECTIVE
  Patients with type 1 diabetes and microalbuminuria are at increased risk of cardiovascular disease (CVD). Abnormalities in vascular progenitor cells, which participate in vascular repair, may be implicated in this susceptibility.
  
  
  METHODS
  We studied the number and function of vascular progenitor cells in 22 type 1 diabetic patients with history of microalbuminuria (MA(+)) and 22 type 1 diabetic patients without history of microalbuminuria (MA(-)), of similar age, diabetes duration, glycemic control, renal function, and no history of CVD.
  
  
  RESULTS
  MA(+) patients had lower circulating CD34(+) and CD34(+)/CD133(+) cell numbers compared with MA(-) patients (P < 0.006). In in vitro functional assays, MA(+) patients had a significantly lower number of colony-forming units and impaired vascular endothelial growth factor (VEGF)-A-mediated tube formation, when compared with MA(-) patients (P < 0.01).
  
  
  CONCLUSIONS
  In type 1 diabetic patients with microalbuminuria, a marker of microvascular injury and a risk factor for CVD, circulating vascular progenitor cell number is reduced and function is impaired.
authors.affiliation: Cardiovascular Division, King's College, London, UK.
authors.forename: Cecile
authors.initials: C
authors.lastname: Dessapt
authors.forename: Janaka
authors.initials: J
authors.lastname: Karalliedde
authors.forename: Maria
authors.initials: M
authors.lastname: Hernandez-Fuentes
authors.forename: Paz
authors.initials: P
authors.lastname: Prieto Martin
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Maltese
authors.forename: Nikesh
authors.initials: N
authors.lastname: Dattani
authors.forename: Ravinder
authors.initials: R
authors.lastname: Atkar
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Viberti
authors.forename: Luigi
authors.initials: L
authors.lastname: Gnudi
mesh_terms: D000071916:AC133 Antigen; D000419:Albuminuria / Q000473:pathology* / Q000503:physiopathology; D015703:Antigens, CD / Q000378:metabolism; D018952:Antigens, CD34 / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000473:pathology*; D042783:Endothelial Cells / Q000166:cytology*; D005260:Female; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology*
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D018952:Antigens, CD34; D006023:Glycoproteins; C000606023:PROM1 protein, human; D010455:Peptides