Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
Parkinson disease (PD) is a chronic neurodegenerative disorder with a cumulative prevalence of greater than one per thousand. To date three independent genome-wide association studies (GWAS) have investigated the genetic susceptibility to PD. These studies implicated several genes as PD risk loci with strong, but not genome-wide significant, associations. In this study, we combined data from two previously published GWAS of Caucasian subjects with our GWAS of 604 cases and 619 controls for a joint analysis with a combined sample size of 1752 cases and 1745 controls. SNPs in SNCA (rs2736990, p-value = 6.7 x 10(-8); genome-wide adjusted p = 0.0109, odds ratio (OR) = 1.29 [95% CI: 1.17-1.42] G vs. A allele, population attributable risk percent (PAR%) = 12%) and the MAPT region (rs11012, p-value = 5.6 x 10(-8); genome-wide adjusted p = 0.0079, OR = 0.70 [95% CI: 0.62-0.79] T vs. C allele, PAR%= 8%) were genome-wide significant. No other SNPs were genome-wide significant in this analysis. This study confirms that SNCA and the MAPT region are major genes whose common variants are influencing risk of PD.
Edwards
Todd L
TL
John P. Hussman Institute for Human Genomics, University of Miami, FL 33136, USA.
Scott
William K
WK
Almonte
Cherylyn
C
Burt
Amber
A
Powell
Eric H
EH
Beecham
Gary W
GW
Wang
Liyong
L
Züchner
Stephan
S
Konidari
Ioanna
I
Wang
Gaofeng
G
Singer
Carlos
C
Nahab
Fatta
F
Scott
Burton
B
Stajich
Jeffrey M
JM
Pericak-Vance
Margaret
M
Haines
Jonathan
J
Vance
Jeffery M
JM
Martin
Eden R
ER
D055106:Genome-Wide Association Study; D006801:Humans; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D051844:alpha-Synuclein / Q000235:genetics* / Q000378:metabolism; D016875:tau Proteins / Q000235:genetics* / Q000378:metabolism
C497604:SNCA protein, human; D051844:alpha-Synuclein; D016875:tau Proteins