Role of neuronal Ca2+-sensor proteins in Golgi-cell-surface membrane traffic.
The regulated local synthesis of PtdIns4P and PtdIns(4,5)P(2) is crucial for TGN (trans-Golgi network)-plasma membrane trafficking. The activity of PI4Kbeta (phosphoinositide 4-kinase IIIbeta) at the Golgi membrane is a first mandatory step in this process. In addition to PI4Kbeta activity, elevated Ca(2+) levels are also needed for the exit of vesicles from the TGN. The reason for this Ca(2+) requirement is at present unclear. In the present review, we discuss the role of neuronal Ca(2+)-sensor proteins in the regulation of PI4Kbeta and suggest that this regulation might impose a need for elevated Ca(2+) levels for a late step of vesicle assembly.
Mikhaylova
Marina
M
Project Group Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany. mikhaylova@ifn-magdeburg.de
Reddy
Pasham Parameshwar
PP
Kreutz
Michael R
MR
D000818:Animals; D001692:Biological Transport / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism* / Q000648:ultrastructure; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D015778:Minor Histocompatibility Antigens; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors / Q000378:metabolism; D022161:Transport Vesicles / Q000378:metabolism; D021601:trans-Golgi Network / Q000378:metabolism* / Q000648:ultrastructure
D002147:Calmodulin; D007527:Isoenzymes; D015778:Minor Histocompatibility Antigens; D017853:Phosphotransferases (Alcohol Group Acceptor); C402182:phosphatidylinositol phosphate 4-kinase; D002118:Calcium