title: [Natural history of multiple sclerosis].
abstract: Multiple sclerosis (MS) is the most frequent chronic, disabling neurological disease in young adults in France. Descriptions of the natural history of large cohorts have provided extensive information about the overall course and prognosis of MS, but individual prognosis remains a major challenge for researchers. Recent studies suggest that the clinical phenotype of MS is mostly age-related and that relapses play a minimal role in the long-term accumulation of disability.
authors.affiliation: Service de neurologie A, centre de coordination EDMUS pour la sclérose en plaques, hôpital neurologique Pierre-Wertheimer, hospices civils de Lyon, 69677 Bron cedex, France. sandra.vukusic@chu-lyon.fr
authors.forename: Sandra
authors.initials: S
authors.lastname: Vukusic
authors.forename: Christian
authors.initials: C
authors.lastname: Confavreux
mesh_terms: D006801:Humans; D009103:Multiple Sclerosis / Q000175:diagnosis; D011379:Prognosis