title: The role of cytotoxic and regulatory T cells in relapsed/refractory Hodgkin lymphoma.
abstract: Recent data suggests the presence of cytotoxic (TIA-1 and granzyme B+) and regulatory T-cells (FOXP3+) in classical Hodgkin lymphoma (cHL) tissues has been shown to correlate with poor overall survival in mainly diagnostic biopsies. By tissue microarray analyses, we extend this observation to a cohort of relapsed/refractory cHL tissue biopsies and analyze immunohistochemical expression of FOXP3, TIA-1, and granzyme B in the inflammatory background and the tumor microenvironment. High expression of TIA-1 (>50%) correlated with poor overall survival (P<0.0001), low expression of FOXP3 (<25%) correlated with poor overall survival (P<0.01), and combined high TIA-1 (>50%) and low FOXP3 (<25%) correlated with poor overall survival (P<0.0001). Expression of cytotoxic and regulatory T-cells shows prognostic significance in the relapsed/refractory clinical setting of cHL.
authors.affiliation: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
authors.forename: Aashiyana F
authors.initials: AF
authors.lastname: Koreishi
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Saenz
authors.forename: Dan O
authors.initials: DO
authors.lastname: Persky
authors.forename: Hayan
authors.initials: H
authors.lastname: Cui
authors.forename: Allison
authors.initials: A
authors.lastname: Moskowitz
authors.forename: Craig H
authors.initials: CH
authors.lastname: Moskowitz
authors.forename: Julie
authors.initials: J
authors.lastname: Teruya-Feldstein
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D019008:Drug Resistance, Neoplasm; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D053804:Granzymes / Q000378:metabolism*; D006689:Hodgkin Disease / Q000175:diagnosis / Q000276:immunology* / Q000401:mortality / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007120:Immunochemistry; D008297:Male; D046228:Microarray Analysis; D008875:Middle Aged; D039102:Poly(A)-Binding Proteins / Q000378:metabolism*; D011237:Predictive Value of Tests; D011379:Prognosis; D012008:Recurrence; D016019:Survival Analysis; D000074019:T-Cell Intracellular Antigen-1; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism* / Q000473:pathology
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D039102:Poly(A)-Binding Proteins; D000074019:T-Cell Intracellular Antigen-1; C071558:TIA1 protein, human; D053804:Granzymes