NCCN Task Force: Transfusion and iron overload in patients with myelodysplastic syndromes.
The National Comprehensive Cancer Network (NCCN) convened a multidisciplinary task force to critically review the evidence for iron chelation and the rationale for treatment of transfusional iron overload in patients with myelodysplastic syndromes (MDS). The task force was charged with addressing issues related to tissue iron toxicity; the role of MRI in assessing iron overload; the rationale and role of treating transfusional iron overload in patients with MDS; and the impact of iron overload on bone marrow transplantation. This report summarizes the background data and ensuing discussion from the NCCN Task Force meeting on transfusional iron overload in MDS.
Greenberg
Peter L
PL
Rigsby
Cynthia K
CK
Stone
Richard M
RM
Deeg
H Joachim
HJ
Gore
Steven D
SD
Millenson
Michael M
MM
Nimer
Stephen D
SD
O'Donnell
Margaret R
MR
Shami
Paul J
PJ
Kumar
Rashmi
R
D026683:Advisory Committees; D015913:Chelation Therapy; D006801:Humans; D007502:Iron Chelating Agents / Q000627:therapeutic use; D019190:Iron Overload / Q000209:etiology / Q000473:pathology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D009190:Myelodysplastic Syndromes / Q000188:drug therapy / Q000628:therapy*; D013789:Thalassemia; D065227:Transfusion Reaction
D007502:Iron Chelating Agents