[Neuropsychiatric manifestations in systemic sclerosis].
Until recently, systemic sclerosis (SSc) was thought to spare the central nervous system (CNS). Neurological symptoms secondary to CNS involvement are very rare in SSc patients. Conversely, the prevalence of depression in SSc patients ranges from 17 to 65% and is much higher than that observed in the general population. Cognitive impairment has been reported in SSc patients, but these findings require confirmation in further studies. Brain calcifications and hyperintense white matter signals (leukoaraiosis) have been documented in SSc patients at a higher incidence than in control populations. Severe leukoaraiosis lesions seem to be associated with severe vascular manifestations in SSc. If morphological CNS abnormalities could be linked to neuropsychiatric manifestations, it would be possible to identify neuropsychiatric scleroderma as we can now identify neuropsychiatric systemic lupus erythematosus.
Launay
David
D
Université Lille 2, Service de médecine interne, Centre de référence de la sclérodermie systémique, Hôpital Claude-Huriez, CHRU Lille, F-59037 Lille Cedex, France.
Baubet
Thierry
T
Cottencin
Olivier
O
Bérezné
Alice
A
Zéphir
Hélène
H
Morell-Dubois
Sandrine
S
Pruvo
Jean-Pierre
JP
Guillevin
Loïc
L
Hatron
Pierre-Yves
PY
Hachulla
Eric
E
Mouthon
Luc
L
D001927:Brain Diseases / Q000209:etiology; D002114:Calcinosis / Q000209:etiology; D002493:Central Nervous System Diseases / Q000209:etiology*; D003072:Cognition Disorders / Q000209:etiology; D003863:Depression / Q000209:etiology; D006801:Humans; D049292:Leukoaraiosis / Q000209:etiology; D001523:Mental Disorders / Q000209:etiology*; D012595:Scleroderma, Systemic / Q000150:complications*; D020293:Vasculitis, Central Nervous System / Q000209:etiology