SUMO and ubiquitin modifications during steroid hormone synthesis and function.
Steroid hormones control many aspects of animal physiology and behaviour. They are highly regulated, among other mechanisms, by post-translational modifications of the transcription factors involved in their synthesis and response. In the present review, we will focus on the influence of SUMO (small ubiquitin-related modifier) and ubiquitin modifications on the function of transcription factors involved in adrenal cortex formation, steroidogenesis and the hormonal response.
Talamillo
Ana
A
CIC bioGUNE, Bizkaia Technology Park, Building 801-A, 48160 Derio, Bizkaia, Spain. atalamillo@cicbiogune.es
Martín
David
D
Hjerpe
Roland
R
Sánchez
Jonatan
J
Barrio
Rosa
R
D000302:Adrenal Cortex / Q000033:anatomy & histology / Q000502:physiology; D000818:Animals; D006801:Humans; D011499:Protein Processing, Post-Translational; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D011987:Receptors, Steroid / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D013256:Steroids / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism*
D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D025841:Small Ubiquitin-Related Modifier Proteins; D013256:Steroids; D014157:Transcription Factors; D025801:Ubiquitin