title: Pyrroloquinoline quinone inhibits the fibrillation of amyloid proteins.
abstract: Several neurodegenerative diseases involve the selective damage of neuron cells resulting from the accumulation of amyloid fibril formation. Considering that the formation of amyloid fibrils as well as their precursor oligomers is cytotoxic, the agents that prevent the formation of oligomers and/or fibrils might allow the development of a novel therapeutic approach to neurodegenerative diseases. Here, we show pyrroloquinoline quinone (PQQ) inhibits the amyloid fibril formation of the amyloid proteins, amyloid beta (1-42) and mouse prion protein. The fibril formation of mouse prion protein in the presence of PQQ was dramatically prevented. Similarly, the fibril formation of amyloid beta (1-42) also decreased. With further advanced pharmacological approaches, PQQ may become a leading anti-neurodegenerative compound in the treatment of neurodegenerative diseases.
authors.affiliation: Department of Biotechnology, Graduate School of Engineering, Tokyo University of Agriculture & Technology, Koganei-shi, Tokyo, Japan.
authors.forename: Jihoon
authors.initials: J
authors.lastname: Kim
authors.forename: Masaki
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Makoto
authors.initials: M
authors.lastname: Fukuda
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ogasawara
authors.forename: Natsuki
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Sungwoong
authors.initials: S
authors.lastname: Han
authors.forename: Chikashi
authors.initials: C
authors.lastname: Nakamura
authors.forename: Masaki
authors.initials: M
authors.lastname: Inada
authors.forename: Chisato
authors.initials: C
authors.lastname: Miyaura
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ikebukuro
authors.forename: Koji
authors.initials: K
authors.lastname: Sode
mesh_terms: D000682:Amyloid / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D045542:PQQ Cofactor / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000682:Amyloid; D045542:PQQ Cofactor