Increased expression of p21-activated kinase in adenomyosis.
The present study was designed to evaluate whether the expression of p21-activated kinase 1 (Pak1), which recently has been shown to be increased in the eutopic endometrium of women with endometriosis, is also increased in adenomyotic nodules as well as in the eutopic endometrium in women with adenomyosis. Comparative immunohistochemical study using a monoclonal antihuman Pak1 antibody revealed that the expression of Pak1 is increased in the eutopic endometrium of women with adenomyosis during the secretory phase, along with its increased expression in adenomyotic nodules, suggesting a possible role of Pak1 in the establishment of adenomyosis.
Kim
So Ra
SR
Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Kim
Sung Hoon
SH
Lee
Hoi Woul
HW
Chae
Hee Dong
HD
Kim
Chung-Hoon
CH
Kang
Byung Moon
BM
D000328:Adult; D002278:Carcinoma in Situ / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D004715:Endometriosis / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D004717:Endometrium / Q000378:metabolism / Q000473:pathology; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008875:Middle Aged; D015854:Up-Regulation; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D014591:Uterine Diseases / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D054462:p21-Activated Kinases / Q000235:genetics* / Q000378:metabolism
C515903:PAK1 protein, human; D054462:p21-Activated Kinases