Modification of vascular and inflammation biomarkers after OGTT in overweight healthy and diabetic subjects.
We evaluated the effect of an oral glucose tolerance test (OGTT) on the level of biomarkers of vascular remodelling. We enrolled 256 Caucasian overweight healthy subjects (H) and 274 overweight type 2 diabetic patients (D). All patients underwent basal measurements of blood glucose (BG), nitrites/nitrates, adiponectin (ADP), matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-9 (MMP-9) before and after OGTT. Nitrites/nitrates decrease was present after 60, 90, 120, and 180 min in both groups. Nitrite/nitrate levels were decreased at baseline, after 30 and 60 min in D group compared to H group. ADP decrease was present after 90, 120, and 180 min, in both groups. ADP levels were lower in D group than in H group during OGTT. MMP-2 increase was present after 60, 90, and 120 min in H group, while MMP-2 increase was observed after 90, 120, and 180 min in D group. MMP-2 levels were higher in D group than in H group during OGTT. MMP-9 increase was present in H group after 60, 90, 120, and 180 min, while MMP-9 increase was observed after 90, 120, and 180 min in D group. MMP-9 levels were higher in D group than in H group during OGTT. Postprandial glycemia induces an acute increase in biomarkers of vascular remodelling.
Derosa
Giuseppe
G
Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S. Matteo, Pavia, P. le C. Golgi, 2 - 27100 PAVIA, Italy. giuseppe.derosa@unipv.it
D'Angelo
Angela
A
Salvadeo
Sibilla A T
SA
Ferrari
Ilaria
I
Fogari
Elena
E
Gravina
Alessia
A
Mereu
Roberto
R
Palumbo
Ilaria
I
Maffioli
Pamela
P
Randazzo
Sabrina
S
Cicero
Arrigo F G
AF
D015415:Biomarkers / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D050177:Overweight / Q000378:metabolism*; D019518:Postprandial Period
D015415:Biomarkers; D001786:Blood Glucose; D009566:Nitrates; D009573:Nitrites; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9