title: Bioavailability of various polyphenols from a diet containing moderate amounts of berries.
abstract: Berries are a rich source of various polyphenols. The objective of this study was to investigate the bioavailability of polyphenols from berries. Middle-aged subjects (n = 72) consumed moderate amounts of berry or control products for 8 weeks in a randomized, placebo-controlled dietary intervention trial. Average intake of berries was 160 g/day (bilberries, lingonberries, black currants, and chokeberries). Plasma and urine polyphenols were analyzed by GC-MS and HPLC and berry polyphenols by HPLC. The total intake of polyphenols was 837 mg/day. Plasma quercetin, p-coumaric acid, 3-hydroxyphenylacetic acid, caffeic acid, protocatechuic acid, vanillic acid, homovanillic acid, and 3-(3-hydroxyphenyl)propionic acid increased significantly from the baseline in the berry group compared to the control group (p < 0.05). The urinary excretion of quercetin, p-coumaric acid, and 3-hydroxyphenylacetic acid increased significantly in the berry group compared to the control group (p < 0.05). In conclusion, a number of polyphenols are bioavailable from a diet containing moderate amounts of blue and red berries.
authors.affiliation: Disease Risk Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland. raika.koli@thl.fi
authors.forename: Raika
authors.initials: R
authors.lastname: Koli
authors.forename: Iris
authors.initials: I
authors.lastname: Erlund
authors.forename: Antti
authors.initials: A
authors.lastname: Jula
authors.forename: Jukka
authors.initials: J
authors.lastname: Marniemi
authors.forename: Pirjo
authors.initials: P
authors.lastname: Mattila
authors.forename: Georg
authors.initials: G
authors.lastname: Alfthan
mesh_terms: D000368:Aged; D001682:Biological Availability; D019587:Dietary Supplements / Q000032:analysis*; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D010636:Phenols / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D059808:Polyphenols; D031965:Ribes / Q000737:chemistry; D029800:Vaccinium myrtillus / Q000737:chemistry; D029801:Vaccinium vitis-idaea / Q000737:chemistry
chemical_list: D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols