Boosting the brain's ability to block inflammation via microRNA-132.
The brain-immune axis continues to fascinate. In this issue of Immunity, Shaked et al. (2009) describe how miR-132 mediates an anti-inflammatory effect via the targeting of acetylcholinesterase, leading to an increase in the neurotransmitter acetylcholine.
O'Neill
Luke A J
LA
School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland. laoneill@tcd.ie
D000109:Acetylcholine / Q000276:immunology / Q000378:metabolism; D000110:Acetylcholinesterase / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D035683:MicroRNAs / Q000819:agonists / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines; D008070:Lipopolysaccharides; C546976:MIRN132 microRNA, mouse; D035683:MicroRNAs; D000110:Acetylcholinesterase; D000109:Acetylcholine