[Classification and clinical analysis of 165 patients with antiphospholipid syndrome.].
OBJECTIVE
Based on 2006 revised classification criteria of definite antiphospholipid syndrome (APS) and definition of new APS subsets, we investigated clinical features of APS patients, correlation between thrombotic events and related antibodies was assessed as well.


METHODS
165 patients with APS were enrolled and analysed retrospectively.


RESULTS
124 female and 41 male patients were included. 116 cases (70.3%), 34 cases (20.6%), 10 cases (6.1%), and 5 cases (3.0%) were classified as definite APS, probable APS, seronegative APS, and microangiopathic APS (MAPS) respectively. Among 124 patients accompanied with other diseases, 113 (91.1%) were autoimmune diseases, mostly systemic lupus erythematosus (79.6%). 121 (73.3%) patients had episodes of thrombosis, with majority of deep vein thrombosis. The patients with positive test of lupus anticoagulant (LA) only were more likely to have episodes of thrombosis than with positive anticardiolipid antibody (ACL) only (86.0% versus 55.7%; P < 0.05). Among 61 patients with prolonged APTT, the presence of LA was detected in 50 (82.0%) patients, and ACL in 34 (55.7%) patients.


CONCLUSIONS
APS patients could be classified into several subgroups according to their clinical features. Venous thromboses are more common than arterial thromboses, and positive of LA correlates thrombosis more than ACL.
Xu
Na
N
Department of Rheumatology Immunology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100032, China. Email: zhangwen91@sina.com.
Zhang
Yao
Y
Zhang
Wen
W
Zhao
Yan
Y
Zeng
Xiao-Feng
XF
D017153:Antibodies, Anticardiolipin; D016736:Antiphospholipid Syndrome; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D008180:Lupus Erythematosus, Systemic; D013927:Thrombosis
D017153:Antibodies, Anticardiolipin; D016682:Lupus Coagulation Inhibitor