Nonresponder patients with hepatitis C virus genotype 2/3 infection: a question of low systemic interferon concentrations?
Twelve of 303 per-protocol patients were nonresponders in a 12-week versus 24-week treatment study of hepatitis C virus (HCV) genotype 2/3 infection. The nonresponders had significantly lower interferon concentrations, as well as significantly greater mean age, body mass index, and viral load. Suboptimal drug concentrations may thus contribute to lack of response to therapy in patients with infection due to HCV genotype 2/3.
Alsiö
Asa
A
Department of Infectious Diseases, University of Gothenburg, Gothenburg, Sweden.
Christensen
Peer Brehm
PB
Färkkilä
Martti
M
Langeland
Nina
N
Buhl
Mads Rauning
MR
Pedersen
Court
C
Mørch
Kristine
K
Haagmans
Bart L
BL
Westin
Johan
J
Hellstrand
Kristoffer
K
Norkrans
Gunnar
G
Lagging
Martin
M
D000328:Adult; D000367:Age Factors; D000906:Antibodies / Q000097:blood; D000998:Antiviral Agents / Q000008:administration & dosage; D015992:Body Mass Index; D004359:Drug Therapy, Combination; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage* / Q000097:blood / Q000276:immunology; D008875:Middle Aged; D015999:Multivariate Analysis; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D012367:RNA, Viral / Q000032:analysis; D011994:Recombinant Proteins; D012254:Ribavirin / Q000008:administration & dosage; D019562:Viral Load
D000906:Antibodies; D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D012367:RNA, Viral; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C100416:peginterferon alfa-2a