title: Paraneoplastic granulomatous vitritis and retinitis as a presentation of recurrent classical Hodgkin's lymphoma.
abstract: We describe a unique case of a patient with an established diagnosis of Hodgkin's lymphoma in clinical remission who later presented with apparent vitreous inflammation. A vitreous biopsy (including fortuitously some peripheral retinal fragments) exhibited granulomatous inflammation. Since the latter can be a paraneoplastic phenomenon of active Hodgkin's lymphoma in distant organ sites, the haematologists were alerted to the possibility of recurrent lymphoma, despite the patient having no clinical symptoms. Repeat body imaging showed enlarged mediastinal lymph nodes, biopsy of which confirmed recurrent Hodgkin's lymphoma. The patient responded well to systemic chemotherapy with resolution of the visual symptoms. This case report illustrates the importance of vitreous biopsy in this clinical setting and how to interpret the significance of granulomas in this context, and outlines a unique vitreo-retinal paraneoplastic granulomatous presentation in the setting of recurrent Hodgkin's lymphoma and how this diagnosis triggered a prompt review of the patient who had no constitutional symptoms, with hopefully a favourable impact on prognosis given the early recurrent disease detection.
authors.affiliation: National Specialist Ophthalmic Pathology Service (NSOPS-Sheffield Lab), Department of Histopathology, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, England, UK. hardeep.mudhar@sth.nhs.uk
authors.forename: Hardeep Singh
authors.initials: HS
authors.lastname: Mudhar
authors.forename: Malee
authors.initials: M
authors.lastname: Fernando
authors.forename: Richard
authors.initials: R
authors.lastname: Sheard
authors.forename: Ian
authors.initials: I
authors.lastname: Rennie
mesh_terms: D000368:Aged; D001706:Biopsy; D005128:Eye Diseases / Q000209:etiology* / Q000473:pathology; D005260:Female; D006099:Granuloma / Q000209:etiology* / Q000473:pathology; D006689:Hodgkin Disease / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008482:Mediastinum; D009364:Neoplasm Recurrence, Local; D010257:Paraneoplastic Syndromes / Q000209:etiology* / Q000473:pathology; D012173:Retinitis / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D014822:Vitreous Body / Q000473:pathology