title: [A case of acinar cell carcinoma of pancreas with liver metastases treated effectively by S-1].
abstract: A 65-year-old man underwent a total gastrectomy and distal pancreatectomy for acinar cell carcinoma of the pancreas. Multiple metastatic liver lesions were found one year postoperatively. He was treated with S-1 chemotherapy over 34 months, and the tumors significantly reduced in size without severe side effects. Four years after surgery, the liver metastases increased in size, associated with pain especially in the right upper quadrant. We then performed right hepatectomy. Peritoneal dissemination and multiple lung metastases were found 8 months after liver resection. Acinar cell carcinoma of the pancreas is a rare and highly malignant tumor, and there are few reports regarding treatment with chemotherapy. Herein, we report a case with multiple liver metastases which were controlled by systemic chemotherapy using S-1.
authors.affiliation: Department of Surgery, School of Medicine, Jichi Medical University, Japan.
authors.forename: Kazue
authors.initials: K
authors.lastname: Morishima
authors.forename: Masanobu
authors.initials: M
authors.lastname: Hyodo
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Nihei
authors.forename: Naohiro
authors.initials: N
authors.lastname: Sata
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Yasuda
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D018267:Carcinoma, Acinar Cell / Q000473:pathology* / Q000628:therapy*; D004338:Drug Combinations; D005743:Gastrectomy; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D010094:Oxonic Acid / Q000627:therapeutic use*; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000628:therapy*; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid