Myelodysplastic syndrome complicated by central diabetes insipidus and cerebral salt wasting syndrome with peculiar change in magnetic resonance images.
Central diabetes insipidus (CDI) could occurs in patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML), because of infiltration of leukemic cells into the neurohypophysis or some other reason and it is closely associated with abnormalities of chromosome 7. We report a case of MDS with abnormalities of chromosome 7, presenting as CDI followed by deterioration of polyuria and hyponatremia with a decreased extracellular fluid volume. Magnetic resonance imaging (MRI) revealed symmetrically enhanced lesions in the hypothalamus. Fludrocortisone treatment normalized his serum sodium level and cerebral salt wasting syndrome (CSWS) was suspected.
Sano
Soichi
S
Department of Internal Medicine, Osaka City General Hospital, Osaka.
Yamagami
Keiko
K
Morikawa
Takashi
T
Yoshioka
Katsunobu
K
D000368:Aged; D001928:Brain Diseases, Metabolic / Q000150:complications / Q000473:pathology*; D020790:Diabetes Insipidus, Neurogenic / Q000150:complications / Q000473:pathology*; D006801:Humans; D007010:Hyponatremia / Q000150:complications / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000473:pathology*