ERp57, a multifunctional endoplasmic reticulum resident oxidoreductase.
ERp57 is a 58-kDa thiol oxidoreductase and a member of the protein disulfide isomerase (PDI)-like family. ERp57 is highly similar to other PDI family members in terms of amino acid sequence and structural/functional domain organization; however, it possesses some distinctive structural features that dictate its unique functions in the cell. This protein plays an important role in endoplasmic reticulum quality control of newly synthesized glycoproteins, is critical in major histocompatability complex (MHC) class I assembly and regulates gene expression. Studies on ERp57-deficient mice indicate that the protein is critical during embryonic development. The protein has been implicated in human pathologies including cancer and Alzheimer's disease.
Coe
Helen
H
Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7.
Michalak
Marek
M
D000544:Alzheimer Disease / Q000201:enzymology*; D000818:Animals; D047108:Embryonic Development; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005786:Gene Expression Regulation; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000201:enzymology*; D010088:Oxidoreductases / Q000235:genetics / Q000378:metabolism*; D019704:Protein Disulfide-Isomerases / Q000235:genetics / Q000378:metabolism*; D017510:Protein Folding; D040681:Structural Homology, Protein
D015395:Histocompatibility Antigens Class I; D010088:Oxidoreductases; D019704:Protein Disulfide-Isomerases; C085868:PDIA3 protein, human