title: The stripe of primary lateral sclerosis: focal primary motor cortex hypometabolism seen on fluorodeoxyglucose F18 positron emission tomography.
abstract: BACKGROUND
  Primary lateral sclerosis (PLS) is a progressive upper motor neuron neurodegenerative condition. The diagnosis is made using clinical history, objective neurological assessment, and exclusion of other neurodegenerative disorders.
  
  
  OBJECTIVE
  To evaluate the role of fluorodeoxyglucose F18 positron emission tomography and 3-dimensional stereotactic surface projection in the diagnosis of PLS.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Outpatient neurology clinic. Patients Three cases of probable PLS. Intervention Fluorodeoxyglucose F18 positron emission tomography in 3 patients with PLS.
  
  
  RESULTS
  Three patients (2 male and 1 female; mean age, 65 years) were identified with a clinical diagnosis of PLS. Fluorodeoxyglucose F18 positron emission tomography demonstrated varying degrees of primary motor cortex hypometabolism.
  
  
  CONCLUSIONS
  Fluorodeoxyglucose F18 positron emission tomography and 3-dimensional stereotactic surface projection provide a useful diagnostic method to support a clinical diagnosis of PLS.
authors.affiliation: Departments of Neurology, Mayo Clinic and Mayo College of Medicine, Rochester, Minnesota 55905, USA.
authors.forename: Daniel O
authors.initials: DO
authors.lastname: Claassen
authors.forename: Keith A
authors.initials: KA
authors.lastname: Josephs
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Peller
mesh_terms: D000368:Aged; D001931:Brain Mapping / Q000379:methods; D003937:Diagnosis, Differential; D018450:Disease Progression; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D020233:Gait Disorders, Neurologic / Q000209:etiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D016472:Motor Neuron Disease / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D010291:Paresis / Q000209:etiology; D049268:Positron-Emission Tomography / Q000379:methods*; D011237:Predictive Value of Tests; D020828:Pseudobulbar Palsy / Q000209:etiology; D011712:Pyramidal Tracts / Q000378:metabolism / Q000503:physiopathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D019788:Fluorodeoxyglucose F18