Cancer-associated myositis and anti-p155 autoantibody in a series of 85 patients with idiopathic inflammatory myopathy.
A new autoantibody against a 155-kDa protein has been described in patients with myositis. We conducted a study to determine the occurrence and types of cancer occurring in a cohort of patients with polymyositis (PM) or dermatomyositis (DM) and analyzed the value of this autoantibody as a serologic marker of cancer-associated myositis (CAM). Serum samples from all patients were examined by protein immunoprecipitation assays with HeLa cells to determine the presence of a 155-kDa protein band. HLA-DRB1 and DQA1 typing was performed by polymerase chain reaction-reverse sequence specific oligonucleotide. Statistical analyses were carried out with the Mann Whitney U and Fisher exact tests. Associations were determined using odds ratios (ORs) with 95% confidence intervals (CI). Eighty-five patients with myositis (20 PM and 65 DM) were included. CAM was detected in 16 patients (19%), 14 with DM. The shawl sign rash was significantly more frequent in patients with CAM than in those without (p < 0.01). Adenocarcinoma was the most frequent type of cancer (87.5%). Anti-p155 autoantibody was found in 1 of the 20 (5%) patients with PM and in 15 of the 65 (23%) patients with DM. A relationship between anti-p155 and CAM was found in DM patients (OR, 23; 95% CI, 5.23-101.2). The HLA-DQA1*0102 allele was not found in any of the anti-p155-positive patients. The prevalence of CAM in our cohort was 19%. Autoantibody against p155 was highly related to CAM and could be a reliable marker of cancer in patients with DM.
Trallero-Araguás
Ernesto
E
From Internal Medicine Department (ETA, MLH, ASOC, MVT), Vall d'Hebron General Hospital, Barcelona; Immunology Department (MAM, JLRS), Hospital de la Santa Creu I Sant Pau, Barcelona; Preventive Medicine and Epidemiology Department (XMG), Universistat Autonoma de Barcelona, Barcelona; LIRAD (EP), Banc Sang I Teixits, Barcelona; Spain.
Labrador-Horrillo
Moisés
M
Selva-O'Callaghan
Albert
A
Martínez
Maria Angeles
MA
Martínez-Gómez
Xavier
X
Palou
Eduard
E
Rodriguez-Sanchez
Jose Luis
JL
Vilardell-Tarrés
Miquel
M
D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000097:blood* / Q000276:immunology*
D001323:Autoantibodies