TLR2 looks at lipoproteins.
Toll-like receptors (TLRs) have evolved to recognize lipoproteins from diverse species of bacteria. In this issue of Immunity, Kang et al. (2009) provide insight into the mechanisms by which TLR2-TLR6 heterodimers recognize diacylated liporoteins, whereas TLR2-TLR1 heterodimers recognize triacylated lipopeptides.
Schenk
Mirjam
M
Division of Dermatology, UCLA School of Medicine, Los Angeles, CA 90095, USA.
Belisle
John T
JT
Modlin
Robert L
RL
D000215:Acylation; D000217:Acyltransferases / Q000276:immunology / Q000378:metabolism; D000818:Animals; D001419:Bacteria / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D008074:Lipoproteins / Q000737:chemistry / Q000276:immunology*; D051194:Toll-Like Receptor 1 / Q000276:immunology*; D051195:Toll-Like Receptor 2 / Q000276:immunology*; D051216:Toll-Like Receptor 6 / Q000276:immunology*
D001425:Bacterial Outer Membrane Proteins; D008074:Lipoproteins; D051194:Toll-Like Receptor 1; D051195:Toll-Like Receptor 2; D051216:Toll-Like Receptor 6; D000217:Acyltransferases