title: How ineffective hypertension control in subjects treated with angiotensin-converting enzyme inhibitors is related to polymorphisms in the renin-angiotensin-aldosterone system.
abstract: OBJECTIVE
  To investigate how genetic polymorphisms of the renin-angiotensin-aldosterone system (RAAS) influence hypertension (HT) control with angiotensin-converting enzyme inhibitor drugs (ACEI).
  
  
  METHODS
  A case-control, cross-sectional population-based nested study (n=1514) included hypertensive patients treated with ACEI drugs, either alone or with other antihypertensive drugs. We differentiated between those who did not control their HT (cases) with those who did (controls). Each group's characteristics were compared to determine the risk of non-controlled HT associated with RAAS polymorphisms by adjusting for different variables.
  
  
  RESULTS
  rs11571074 obtained an ORa of 5.26 for T/T (1.25-20). rs5945377 obtained an ORa 16.16 (1.61-162.62) for genotypes G/G-G/C. rs909383, rs275649 and rs4681444 obtained an ORa of 4.00 (1.19-14.28), 5.89 (1.53-25) and 3.89 (1.53-25) when genotypes C/C and A/A were expressed for the first and for the other two, respectively. For rs2272089, rs13117325 and rs11099680, a higher non-control risk was seen in A/G-G/G carriers (ORa: 4.9 (1.3-18.3); ORa: 3.7 (1.0-13.4); ORa: 6.5 (1.7-24.7). Finally, rs6535598 obtained an ORa of 10.4 (1.2-92.9) in T/T carriers.
  
  
  CONCLUSIONS
  Although this study shows a possible association of polymorphisms of RAAS genes with the risk of non-control of HT in ACEI-treated patients and indicates the importance of all this system's components in regulating HT, it needs to be replicated in other data sources.
authors.affiliation: Unit of Public Health and Environmental Care, Department of Preventive Medicine, University of Valencia, Valencia, Spain.
authors.forename: Maria M
authors.initials: MM
authors.lastname: Morales-Suárez-Varela
authors.forename: Maria L
authors.initials: ML
authors.lastname: Mansego
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Martín-Escudero
authors.forename: Agustín
authors.initials: A
authors.lastname: Llopis-González
authors.forename: Felipe Javier
authors.initials: FJ
authors.lastname: Chaves
authors.forename: Raul
authors.initials: R
authors.lastname: López-Izquierdo
authors.forename: Raul
authors.initials: R
authors.lastname: Frutos-Llanes
authors.forename: Ana M
authors.initials: AM
authors.lastname: Vicedo-Cabrera
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors