Cardioprotection in ischemia/reperfusion injury: spotlight on sphingosine-1-phosphate and bradykinin signalling.
Complex signal-transduction cascades are known to be involved in regulating cardiomyocyte function, death and survival during acute cardiac ischemia-reperfusion process, but detailed survival signalling pathways are not clear. This review presents and discusses the recent findings bearing upon the evidence on the cardioprotective effect of sphingosine-1-phosphate (S1P) and bradykinin in acute cardiac ischemia-reperfusion and underlying signalling mechanisms, particularly, through activation of P21 activated kinase.
Egom
Emmanuel Eroume A
EE
Victoria Hospital, Cardiology, Hayfield Road, Kirkcaldy, Fife KY2 5AH, UK.
Ke
Yunbo
Y
Solaro
R John
RJ
Lei
Ming
M
D054058:Acute Coronary Syndrome / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008246:Lysophospholipids / Q000494:pharmacology / Q000627:therapeutic use*; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control*; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D054462:p21-Activated Kinases / Q000378:metabolism
D008246:Lysophospholipids; C060506:sphingosine 1-phosphate; D054462:p21-Activated Kinases; D013110:Sphingosine; D001920:Bradykinin