title: Quantitative CT assessment of chronic obstructive pulmonary disease.
abstract: Chronic obstructive pulmonary disease (COPD) is characterized by the presence of airflow limitation that is caused by a combination of small airway remodeling and emphysema-induced loss of elastic recoil. The management of COPD depends on the relative distribution and severity of these two pathologic processes, factors that may vary widely even among patients with a similar degree of airflow limitation. Standard lung function testing with spirometry is unhelpful for distinguishing the specific contribution of each process. Pathologic changes such as emphysema and modification of the small and large airways are better evaluated with quantitative analyses of image data from multidetector computed tomography (CT). CT-based quantitative analyses can help differentiate the COPD phenotype (emphysema-predominant, airway-predominant, or mixed), which is crucial information for determining the appropriate management strategy.
authors.affiliation: Department of Radiology and Pulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. shin4114@mac.com
authors.forename: Shin
authors.initials: S
authors.lastname: Matsuoka
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Yamashiro
authors.forename: George R
authors.initials: GR
authors.lastname: Washko
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kurihara
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Hiroto
authors.initials: H
authors.lastname: Hatabu
mesh_terms: D000368:Aged; D004646:Emphysema / Q000150:complications / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000000981:diagnostic imaging*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*