A pH-driven DNA switch based on the A+ x G mispair.
A new approach to the development of pH-driven DNA switches is presented. Here, the improved stability of the A x G mispair under slightly acidic conditions is exploited. The temperature tunability and the potential generality of the approach are discussed.
Lee
Jennifer A
JA
Chemistry Department, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada.
DeRosa
Maria C
MC
D000225:Adenine / Q000737:chemistry*; D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D019791:Guanidine / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009690:Nucleic Acid Conformation; D011522:Protons; D013696:Temperature
D011522:Protons; D004247:DNA; D000225:Adenine; D019791:Guanidine