Ubiquitin and SUMO signalling in DNA repair.
The repair of lesions and gaps in DNA follows different pathways, each mediated by specific proteins and complexes. Post-translational modifications in many of these proteins govern their activities and interactions, ultimately determining whether a particular pathway is followed. Prominent among these modifications are the addition of phosphate or ubiquitin (and ubiquitin-like) moieties that confer new binding surfaces and conformational states on the modified proteins. The present review summarizes some of consequences of ubiquitin and ubiquitin-like modifications and interactions that regulate nucleotide excision repair, translesion synthesis, double-strand break repair and interstrand cross-link repair, with the discussion of relevant examples in each pathway.
Thomson
Timothy M
TM
Laboratory of Cell Signaling and Cancer, Department of Cell Biology, Instituto de Biología Molecular de Barcelona, Consejo Superior de Investigaciones Científicas, Parque Científico de Barcelona, Edificio Hélice, Baldiri Reixac 15-21, 08028 Barcelona, Spain. titbmc@ibmb.csic.es
Guerra-Rebollo
Marta
M
D000818:Animals; D019313:BRCA1 Protein / Q000235:genetics / Q000378:metabolism; D044842:Cullin Proteins / Q000378:metabolism; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D045643:DNA Repair Enzymes / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D005199:Fanconi Anemia / Q000235:genetics / Q000503:physiopathology; D018816:Genes, cdc; D006801:Humans; D046912:Multiprotein Complexes / Q000378:metabolism; D010766:Phosphorylation; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*; D054875:Ubiquitination
D019313:BRCA1 Protein; D044842:Cullin Proteins; D004268:DNA-Binding Proteins; D046912:Multiprotein Complexes; D018809:Proliferating Cell Nuclear Antigen; D025841:Small Ubiquitin-Related Modifier Proteins; D025801:Ubiquitin; D045643:DNA Repair Enzymes