Kickstarting Foxp3 with c-Rel.
In this issue of Immunity, reports by Long et al. (2009) and Ruan et al. (2009) suggest that the transcription factor NF-kappaB-c-Rel is an important molecular mechanism by which T cell receptor-specificity for self-antigens instructs the selection of Foxp3(+) regulatory T cells.
Hsieh
Chyi-Song
CS
Department of Internal Medicine, Division of Rheumatology, Washington University, Saint Louis, MO 63110, USA.
D000818:Animals; D001324:Autoantigens / Q000276:immunology; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D051379:Mice; D016328:NF-kappa B / Q000276:immunology* / Q000378:metabolism; D020569:Proto-Oncogene Proteins c-rel / Q000276:immunology* / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism
D001324:Autoantigens; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D016328:NF-kappa B; D020569:Proto-Oncogene Proteins c-rel; D011948:Receptors, Antigen, T-Cell