title: Rapid two-step synthesis of drug-like polycyclic substances by sequential multi-catalysis cascade reactions.
abstract: An efficient amino acid-/self-/base-/ruthenium-/thermal-catalyzed two-step process for the synthesis of functionalized drug-like carbocycles was achieved through combinations of cascade TCRA/C-allylation/enyne-RCM/Diels-Alder reactions as key steps starting from simple acyclic substrates. In this communication, we report the two-step synthesis of drug-like carbocycles through a combination of organocatalysis with ruthenium-catalysis.
authors.affiliation: School of Chemistry, University of Hyderabad, Hyderabad-500 046, India. ramsc@uohyd.ernet.in
authors.forename: Dhevalapally B
authors.initials: DB
authors.lastname: Ramachary
authors.forename: Rumpa
authors.initials: R
authors.lastname: Mondal
authors.forename: Chintalapudi
authors.initials: C
authors.lastname: Venkaiah
mesh_terms: D002384:Catalysis; D055772:Green Chemistry Technology; D007700:Kinetics; D009942:Organometallic Compounds / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D011392:Proline / Q000737:chemistry; D013696:Temperature
chemical_list: D009942:Organometallic Compounds; D004364:Pharmaceutical Preparations; D011083:Polycyclic Compounds; D011392:Proline