Nucleocytoplasmic transport in yeast: a few roles for many actors.
Eukaryotic cells have developed a series of highly controlled processes of transport between the nucleus and cytoplasm. The present review focuses on the latest advances in our understanding of nucleocytoplasmic exchange of molecules in yeast, a widely studied model organism in the field. It concentrates on the role of individual proteins such as nucleoporins and karyopherins in the translocation process and relates this to how the organization of the nuclear pore complex effectively facilitates the bidirectional transport between the two compartments.
Fiserova
Jindriska
J
School of Biological and Biomedical Sciences, Durham University, Sciences Laboratories, South Road, Durham DH1 3LE, UK.
Goldberg
Martin W
MW
D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D028884:Karyopherins / Q000378:metabolism; D022022:Nuclear Pore / Q000378:metabolism*; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism
D028884:Karyopherins; D028861:Nuclear Pore Complex Proteins; D029701:Saccharomyces cerevisiae Proteins