Use of zoledronic acid in the treatment of Gorham's disease.
Gorham's disease (Gorham-Stout syndrome) is a rare condition of unknown etiology involving a localized endothelial proliferation of lymph vessels resulting in destruction with bone resorption. The syndrome is rarely seen in the facial skeleton and has a large variety of prognoses and treatments. A case of this syndrome in a 9-year-old boy is presented. The clinical aspects are described, together with the treatment involving zoledronic acid. Other treatments described in the literature are reviewed. The authors believe that this report is one of the first cases in which a child afflicted in the first decade of life survives.
Avelar
Rafael Linard
RL
Department of Oral and Maxillofacial Surgery, Universidade de Pernambuco, Recife, Brazil. rafael.ctbmf@yahoo.com.br
Martins
Valber Barbosa
VB
Antunes
Antonio Azoubel
AA
de Oliveira Neto
Patricio José
PJ
Andrade
Emanuel Sávio de Souza
ES
D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D002648:Child; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D008334:Mandible / Q000473:pathology; D010015:Osteolysis, Essential / Q000188:drug therapy* / Q000473:pathology; D000077211:Zoledronic Acid
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid