title: Neuroglobin expression in ischemic stroke.
abstract: OBJECTIVE
  We investigated whether neuroglobin, a neuronal protein that protects neurons from hypoxic-ischemic injury, is upregulated in ischemic stroke.
  
  
  METHODS
  Neuroglobin immunoreactivity was measured in brain tissue from control subjects and patients with ischemic stroke.
  
  
  RESULTS
  Neuroglobin was detected in several brain areas, and its expression was increased in the cortical peri-infarct region after stroke.
  
  
  CONCLUSIONS
  Ischemic stroke increases expression of the neuroprotective protein neuroglobin, suggesting neuroglobin may represent a novel target for stroke therapy.
authors.forename: Kunlin
authors.initials: K
authors.lastname: Jin
authors.forename: Ying
authors.initials: Y
authors.lastname: Mao
authors.forename: Xiao
authors.initials: X
authors.lastname: Mao
authors.forename: Lin
authors.initials: L
authors.lastname: Xie
authors.forename: David A
authors.initials: DA
authors.lastname: Greenberg
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000378:metabolism* / Q000517:prevention & control; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D005914:Globins / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D000078787:Neuroglobin; D020521:Stroke / Q000378:metabolism* / Q000517:prevention & control; D015854:Up-Regulation / Q000502:physiology
chemical_list: D009419:Nerve Tissue Proteins; D000078787:Neuroglobin; D005914:Globins