HIV protease inhibitors, indinavir or nelfinavir, augment antimalarial action of artemisinin in vitro.
Most malaria endemic regions are co-infested with HIV infection. Treatment of one may affect outcome of the other in co-infected individuals. HIV protease inhibitors, indinavir or nelfinavir, are important antiretroviral drugs and artemisinin is central to malaria treatment. We show these protease inhibitors augment the antimalarial activity of artemisinin against P. falciparum in vitro.
Mishra
Lokesh C
LC
Department of Zoology, University of Delhi, Delhi, India. lokesh20sept@yahoo.co.in
Bhattacharya
Amit
A
Sharma
Manish
M
Bhasin
Virendra K
VK
D000962:Antimalarials / Q000008:administration & dosage / Q000627:therapeutic use*; D037621:Artemisinins / Q000008:administration & dosage / Q000627:therapeutic use*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D019469:Indinavir / Q000008:administration & dosage / Q000627:therapeutic use*; D008288:Malaria / Q000150:complications / Q000188:drug therapy*; D019888:Nelfinavir / Q000008:administration & dosage / Q000627:therapeutic use*
D000962:Antimalarials; D037621:Artemisinins; D017320:HIV Protease Inhibitors; D019469:Indinavir; C031327:artemisinin; D019888:Nelfinavir