title: [Nipple adenoma: report of 18 cases with review of literatures].
abstract: OBJECTIVE
  To investigate the clinicopathological and immunohistochemical features, diagnosis and differential diagnosis of nipple adenoma of the breast.
  
  
  METHODS
  Morphological observation and immunohistochemistry were applied to 18 cases of nipple adenoma with a review of the related literatures.
  
  
  RESULTS
  The neoplasms were localized at nipples or under the areola of breast, adherent to the epidermis, mainly composed of dilated ducts in a tubular appearance associated with fibrotic matrix. The glandular epithelium showed various type of proliferation, forming thick layers or complex structures such as papillae, micropapillae, tufts, fronds, arcades or bridges accompanying with solid or cribriform cell nests. The tumor cells were crowding, lack of an uniform morphology and polarity with intact myoepithelial cells around the ducts. By immunostaining, the glandular epithelium was diffusely positive for 34betaE12, patchily positive for CK5/6, and negative for p53 and c-erbB-2. The myoepithelium, positive for p63, smooth muscle actin and Calponin, was well preserved and outlining the ducts.
  
  
  CONCLUSIONS
  Nipple adenoma is an infrequent type of benign breast neoplasm, presenting as sclerosing papilloma, papillomatosis or florid sclerosing adenosis. It is easily confused with atypical ductal hyperplasia/low grade ductal carcinoma in situ, invasive ductal carcinoma or low grade adenosquamous carcinoma. A correct diagnosis is based on the peculiar location and morphology of the tumor, and immunohistochemistry is helpful in some cases.
authors.affiliation: Department of Pathology, General Hospital of Beijing Military Command, Beijing 100700, China.
authors.forename: Guang-zhi
authors.initials: GZ
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Hua-ye
authors.initials: HY
authors.lastname: Ding
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000328:Adult; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002278:Carcinoma in Situ / Q000378:metabolism / Q000473:pathology; D018196:Carcinoma, Adenosquamous / Q000378:metabolism / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D053555:Keratin-5 / Q000378:metabolism; D007633:Keratins / Q000378:metabolism; D008875:Middle Aged; D009558:Nipples / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
chemical_list: C121278:CK-34 beta E12; D053555:Keratin-5; D007633:Keratins