Phloroglucinol glycosides from the fresh fruits of Eucalyptus maideni.
Five new phloroglucinol glycosides, eucalmainosides A-E (1-5), were isolated from the fresh fruits of Eucalyptus maideni, along with 15 flavonoids (6-20), seven (+)-oleuropeic acid derivatives (15, 16, and 22-26), three hydrolyzable tannins (32-34), and six simple phenolic compounds (21, 27-31). Their structures were determined on the basis of spectroscopic analyses, including HSQC, HMBC, and acidic hydrolysis. The in vitro anti-herpes simplex virus 1 (HSV-1) assay indicated that the flavonols, myricetin (6) and quercetin (7), and the ellagitannin isocoriariin F (33) showed weak anti-HSV-1 activity with TIC values of 0.31, 0.33, and 0.12 mM, respectively.
Tian
Li-Wen
LW
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Zhang
Ying-Jun
YJ
Qu
Chang
C
Wang
Yi-Fei
YF
Yang
Chong-Ren
CR
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D003509:Cyclohexanecarboxylic Acids / Q000737:chemistry / Q000302:isolation & purification; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005052:Eucalyptus / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010696:Phloroglucinol / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014709:Vero Cells
D000998:Antiviral Agents; D003509:Cyclohexanecarboxylic Acids; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D006027:Glycosides; D047348:Hydrolyzable Tannins; C013515:ellagitannin; C417926:oleuropeic acid; D010696:Phloroglucinol