Acute human parvovirus B19 infection and nephrotic syndrome in patients with sickle cell disease.
Acute Human Parvovirus B19 (HPV B19) infection is the major cause of transient red cell aplasia (TRCA) and acute anaemia in patients with sickle cell disease (SCD). We report three cases of patients who developed nephrotic syndrome (NS) with chronic sequelae after initially presenting with HPV B19-associated TRCA. There was no correlation between evidence of HPV B19 infection and impaired renal function in our cohort of adult sickle cell patients. This is consistent with a view that although NS is potentially a rare complication of symptomatic acute HPV B19 infection, exposure to HPV B19 is not associated with an increased risk of renal disease.
Quek
Lynn
L
Department of Haematological Medicine, King's College Hospital NHS Trust, Denmark Hill, London, UK.
Sharpe
Claire
C
Dutt
Neelanjana
N
Height
Sue
S
Allman
Marlene
M
Awogbade
Moji
M
Rees
David C
DC
Zuckerman
Mark
M
Thein
Swee Lay
SL
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000755:Anemia, Sickle Cell / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology / Q000821:virology*; D010322:Parvoviridae Infections / Q000150:complications*; D016732:Parvovirus B19, Human; D012010:Red-Cell Aplasia, Pure / Q000821:virology; D055815:Young Adult