Chemical reprogramming of Caenorhabditis elegans germ cell fate.
Small molecules can control cell fate in vivo and may allow directed induction of desired cell types, providing an attractive alternative to transplant-based approaches in regenerative medicine. We have chemically induced functional oocytes in Caenorhabditis elegans adults that otherwise produced only sperm. These findings suggest that chemical approaches to therapeutic cell reprogramming may be feasible and provide a powerful platform for analyzing molecular mechanisms of in vivo cell reprogramming.
Morgan
Clinton T
CT
Medical Scientist Training Program, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Lee
Myon-Hee
MH
Kimble
Judith
J
D000818:Animals; D002070:Butadienes / Q000737:chemistry / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000166:cytology* / Q000187:drug effects* / Q000196:embryology; D002454:Cell Differentiation / Q000187:drug effects; D019070:Cell Lineage / Q000187:drug effects; D065150:Cellular Reprogramming; D005260:Female; D020935:MAP Kinase Signaling System / Q000187:drug effects; D008297:Male; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry / Q000494:pharmacology*; D009865:Oocytes / Q000166:cytology / Q000187:drug effects; D013094:Spermatozoa / Q000166:cytology
D002070:Butadienes; D009570:Nitriles; C113580:U 0126