[A case of advanced gastric cancer with a complete response to S-1 plus CPT-11 chemotherapy for eight years].
A 70-year-old male presented with type 2 gastric cancer in the antrum with an involved lymph node which measured 50 mm in diameter and was attached to the proper and common hepatic artery. We tried to perform a radical operation, but it was impossible to dissect the lymph node involved with the proper hepatic and left hepatic artery. Finally, we performed an incisional biopsy of the involved lymph node, and confirmed it to be a metastasis from gastric cancer. Combination chemotherapy with S-1 and CPT-11 was administered after surgery. The tumor shrunk after two courses of chemotherapy, and computed tomography (CT) showed the involved lymph node had shrunk 25 mm after 6 courses. CT showed no swelling of the lymph nodes after 10 courses. Furthermore, an endoscopic examination revealed a scar, and no cancer cells were found in a biopsy specimen of the scar tissue. As a result, we diagnosed a complete response to this treatment. No radical operation was performed according to the patient's wishes. This chemotherapy protocol continued for two years and has now finished. So far, no recurrent disease has been detected for eight years since a complete response was confirmed in this patient.
Inokuchi
Mikito
M
Department of Esophago-Gastric Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Kojima
Kazuyuki
K
Yamada
Hiroyuki
H
Kato
Keiji
K
Kawano
Tatsuyuki
T
Sugihara
Kenichi
K
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D004338:Drug Combinations; D006801:Humans; D000077146:Irinotecan; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage; D011706:Pyloric Antrum; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy*; D005641:Tegafur / Q000008:administration & dosage
D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000077146:Irinotecan; D002166:Camptothecin