A complex karyotype including a t(2;11) in a paediatric ependymoma: case report and review of the literature.
Ependymomas are glial tumours representing approximately 5-10% of all intracranial tumours and are the third most common primary brain tumour in childhood. Only a few karyotypic studies on paediatric ependymomas have been published and no specific chromosomal aberration has been specifically related to this type of cancer. We performed cytogenetic analysis of an ependymoma in an 11-year-old boy. Our patient showed a complex karyotype, characterized by a near-tetraploidy and a sole structural unbalanced aberration: der(2)t(2;11)(q11.2;q13.1), which has not been described before. We here discuss such cytogenetic findings, comparing our data with those reported in the literature.
Aschero
Simona
S
Department of Paediatric Haematology/Oncology, University of Turin, Piazza Polonia, 94, 10126 Torino, Italy. simona.aschero@unito.it
Vallero
Stefano
S
Morra
Isabella
I
Impera
Luciana
L
Forni
Marco
M
Sandri
Alessandro
A
Basso
Maria E
ME
Storlazzi
Clelia T
CT
Giordano
Flavio
F
Fidani
Paola
P
De Ioris
Maria A
MA
di Montezemolo
Luca Cordero
LC
D001932:Brain Neoplasms / Q000235:genetics*; D002648:Child; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D004806:Ependymoma / Q000235:genetics*; D006801:Humans; D007621:Karyotyping / Q000379:methods*; D008297:Male; D014178:Translocation, Genetic