Immunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinoma.
OBJECTIVE
To correlate the expression of p53 protein and VEGF with the prognosis of patients submitted to curative resection to treat esophageal adenocarcinoma.


METHODS
Forty-six patients with esophageal adenocarcinoma, submitted to curative resection, were studied. The expressions of p53 protein and VEGF were assessed by immunohistochemistry in 52.2% and 47.8% of tumors, respectively.


RESULTS
P53 protein and VEGF expressions coincided in 26% of the cases, and no correlation between these expressions was observed. None of the clinicopathological factors showed a significant correlation with p53 protein or VEGF expressions. There was no significant association between p53 protein and VEGF expressions and long-term survival.


CONCLUSIONS
The expression of p53 protein and VEGF did not correlate with prognosis in esophageal adenocarcinoma patients submitted to curative resection.
Cavazzola
Leandro Totti
LT
Departamento de Patologia, UFRGS, RS, BR. cavazzola@gmail.com
Rosa
André Ricardo Pereira da
AR
Schirmer
Carlos Cauduro
CC
Gurski
Richard Ricachenevski
RR
Telles
João Pedro Bueno
JP
Mielke
Fernando
F
Meurer
Luíse
L
Edelweiss
Maria Isabel Albano
MI
Kruel
Cleber Dario Pinto
CD
D000230:Adenocarcinoma / Q000737:chemistry / Q000378:metabolism* / Q000401:mortality*; D000328:Adult; D000368:Aged; D004938:Esophageal Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000401:mortality*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D015996:Survival Rate; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000096:biosynthesis*; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis* / Q000096:biosynthesis*
D016159:Tumor Suppressor Protein p53; D042461:Vascular Endothelial Growth Factor A