Polycyclic indole alkaloid-type compounds by MCR.
Polycyclic indole moieties are often part of bioactive natural or synthetic products, however traditionally have to be synthesized over several steps involving time consuming sequential multi-step syntheses. We herein communicate an efficient and flexible 2-step procedure to complex multicyclic indole alkaloid-type compounds involving Ugi MCR and Pictet-Spengler reaction.
Wang
Wei
W
University of Pittsburgh, Drug Discovery Institute, Pittsburgh, PA 15261, USA.
Herdtweck
Eberhardt
E
Dömling
Alexander
A
D018360:Crystallography, X-Ray; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D026121:Indole Alkaloids; D011083:Polycyclic Compounds