title: Reduction in postprandial glucose excursion and prolongation of satiety: possible explanation of the long-term effects of whole grain Salba (Salvia Hispanica L.).
abstract: Despite strong correlations linking whole-grain consumption to reductions in heart disease, the physiological mechanisms involved remain ambiguous. We assessed whether Salba (Salvia Hispanica L.) whole grain reduces postprandial glycemia in healthy subjects, as a possible explanation for its cardioprotective effects observed in individuals with diabetes. The study used acute, randomized, double-blind, controlled design in which 11 healthy individuals (6 males and 5 females; body mass index 22.3+/-2.8 kg/m(2)) received 0, 7, 15 or 24 g of Salba baked into white bread. Capillary samples and appetite ratings were collected over 2 h after consumption. A dose-response reduction in postprandial glycemia (P=0.002, r(2)=0.203) was observed with all three doses of Salba, significantly decreasing incremental areas under the curve (iAUCs) and time point-specific blood glucose (P<0.05). Appetite ratings were decreased at 60 min after high, 90 min after high and intermediate and at 120 min after all treatments (P<0.05). Decrease in postprandial glycemia provides a potential explanation for improvements in blood pressure, coagulation and inflammatory markers previously observed after 12-week Salba supplementation in type II diabetes.
authors.affiliation: Clinical Nutrition and Risk Factor Modification Centre, St Michael's Hospital, Toronto, Ontario, Canada. v.vuksan@utoronto.ca
authors.forename: V
authors.initials: V
authors.lastname: Vuksan
authors.forename: A L
authors.initials: AL
authors.lastname: Jenkins
authors.forename: A G
authors.initials: AG
authors.lastname: Dias
authors.forename: A S
authors.initials: AS
authors.lastname: Lee
authors.forename: E
authors.initials: E
authors.lastname: Jovanovski
authors.forename: A L
authors.initials: AL
authors.lastname: Rogovik
authors.forename: A
authors.initials: A
authors.lastname: Hanna
mesh_terms: D000328:Adult; D001066:Appetite / Q000187:drug effects*; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D001939:Bread; D002318:Cardiovascular Diseases / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D028321:Plant Preparations / Q000494:pharmacology* / Q000627:therapeutic use; D019518:Postprandial Period; D012016:Reference Values; D012307:Risk Factors; D027544:Salvia; D012527:Satiation / Q000187:drug effects*; D012639:Seeds
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D010936:Plant Extracts; D028321:Plant Preparations