title: [Successful treatment with S-1 + CPT-11 for hepatic metastasis from gastric cancer--a case report].
abstract: The patient was a 67-year-old male with Type 3 gastric cancer who underwent distal gastrectomy and D2 dissection in December 2004. It was diagnosed to be a cancer of se, n(1+), Stage IIIA. In October 2006, 22 months after the operations, abdominal CT showed multiple tumors with a maximum diameter of 35 mm in both hepatic lobes. The tumors were diagnosed as multiple hepatic metastases of the gastric cancer. After 5 courses of concomitant S-1+CPT-11 therapy, abdominal CT in February 2007 showed complete elimination of the multiple tumors in both hepatic lobes, and it was considered that a complete response (CR) had been obtained. After initiation of the treatment, 32 courses of S-1+CPT-11 therapy were performed, and at present, 24 months after the therapy, the patient has survived with no redevelopment of the cancer. All of the treatments were performed in an outpatient setting, and no side effects have been confirmed other than grade 1 gastric and skin symptoms. We experienced a case in which CR was achieved by S-1+CPT-11 therapy in a patient with hepatic metastasis of a gastric cancer.
authors.affiliation: Department of Surgery, Ichijokai Hospital, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Takahashi
authors.forename: Mitsugu
authors.initials: M
authors.lastname: Kochi
authors.forename: Noriaki
authors.initials: N
authors.lastname: Kanamori
authors.forename: Teruo
authors.initials: T
authors.lastname: Kaiga
authors.forename: Masashi
authors.initials: M
authors.lastname: Fujii
authors.forename: Tadatoshi
authors.initials: T
authors.lastname: Takayama
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D004338:Drug Combinations; D005743:Gastrectomy; D006801:Humans; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000077146:Irinotecan; D002166:Camptothecin