title: Efects of melatonin and octreotide on peridural fibrosis in an animal model of laminectomy.
abstract: OBJECTIVE
  To investigate the effects of melatonin and octreotide in the prevention of peridural fibrosis in an experimental rat model.
  
  
  METHODS
  A total of 36 rats were divided into three groups: Group I was laminectomized and not given any treatment. Group II received an intraperitoneal 30 microg/kg/day dose of octreotide for six weeks after the laminectomy. Group III rats were injected with melatonin 7.5 mg/kg/day for six weeks after the laminectomy. At the end of six weeks, plasma transforming growth factor beta-1 levels and peridural fibrous tissue hydroxyproline concentrations were determined and histopathological examinations was performed.
  
  
  RESULTS
  Serum TGF-Beta1 levels of the octreotide and melatonin groups were found to be lower than the control group. The lower levels of TGF-Beta1 was statistically significant in both of the groups. Hydroxyproline levels of the octreotide and melatonin groups were found to be lower than that of the control group. The decrease was statistically significant only in the melatonin group. Peridural fibrosis scores of the octreotide and melatonin groups were lower than the control group. This histopathological improvement was statistically significant only in the melatonin group.
  
  
  CONCLUSIONS
  Melatonin and octreotide prevented TGF-Beta1 increase in peridural fibrosis, but only melatonin significantly improved hyroxyproline levels and fibrosis scores as demonstrated.
authors.affiliation: Firat University, Faculty of Medicine, Department of Neurosurgery, Elaziğ, Turkey. fserol@yahoo.com
authors.forename: Fatih Serhat
authors.initials: FS
authors.lastname: Erol
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kavakli
authors.forename: Necip
authors.initials: N
authors.lastname: Ilhan
authors.forename: Ibrahim Hanifi
authors.initials: IH
authors.lastname: Ozercan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sarsilmaz
mesh_terms: D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology / Q000627:therapeutic use; D005355:Fibrosis / Q000145:classification / Q000188:drug therapy* / Q000473:pathology; D007796:Laminectomy / Q000379:methods*; D008159:Lumbar Vertebrae; D008297:Male; D008550:Melatonin / Q000494:pharmacology / Q000627:therapeutic use*; D015282:Octreotide / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D053773:Transforming Growth Factor beta1 / Q000097:blood
chemical_list: D002492:Central Nervous System Depressants; D053773:Transforming Growth Factor beta1; D008550:Melatonin; D015282:Octreotide