[A systematic review on the protective efficacy of BCG against children tuberculosis meningitis and millet tuberculosis].
OBJECTIVE
To Understand the protective efficacy of Bacillus Calmette Guerin (BCG) vacciation against children tuberculosis meningitis and millet tuberculosis, to provide the data to improve immune tactics of BCG.


METHODS
A search CHKD full text database (1979-2007) and CHKD meeting paper database (1999-2008) and WANGFANG database (1982-2007), with BCG, tuberculosis meningitis, millet tuberculosis, then to analyze information from qualified literatures.


RESULTS
28 paper were involved. 25 were correlated with tuberculosis meningitis, 1 correlated with millet tuberculosis, 2 correlated with both. The study about protections of BCG against tuberculosis meningitis showed that BCG has protective action in ecology study. The inoculation of BCG in tuberculosis meningitis cases was 0-69.08%, millet tuberculosis BCG inoculating with 82.76%. Result of Mete analysis showed that it was 81% to the protection tuberculosis meningitis, 95% CI is 57%-91%.


CONCLUSIONS
BCG vaccine has protective effect for preventing tuberculous meningitis. Due to lack of case-control study, cases in vaccinated and unvaccinated ratio should not an objective description of the effect of BCG vaccination. Protective effect of miliary tuberculosis research literature was less, unable to come to precise conclusions.
Xiong
Chang-Hui
CH
Nangchang City Center for Disease Control and Prevention, Nanchang 330006, Jiangxi, China.
Liang
Xiao-Feng
XF
Wang
Hua-Qing
HQ
D000293:Adolescent; D001500:BCG Vaccine / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D020011:Protective Agents / Q000008:administration & dosage*; D014376:Tuberculosis / Q000382:microbiology / Q000517:prevention & control*; D014390:Tuberculosis, Meningeal / Q000382:microbiology / Q000517:prevention & control*; D014611:Vaccination
D001500:BCG Vaccine; D020011:Protective Agents