Could aging human skin use a connective tissue growth factor boost to increase collagen content?
The roles of connective tissue growth factor (CTGF) and transforming growth factor-beta (TGF-beta), both well-known collagen production stimulators, were examined in skin aging. Aged skin and fibroblasts exhibited a coordinate decrease in CTGF, TGF-beta, and type I procollagen expression and content. CTGF knockdown and TGF-beta blockade in normal dermal fibroblasts reduced procollagen expression, whereas overexpressing CTGF increased procollagen by a TGF-beta/Smad signaling-dependent mechanism without involving Smad2/3.
Oliver
Noelynn
N
Therapeutics Research, FibroGen, Inc., San Francisco, California 94080, USA. noelynnoliver@yahoo.com
Sternlicht
Mark
M
Gerritsen
Karin
K
Goldschmeding
Roel
R
D000818:Animals; D003094:Collagen / Q000737:chemistry / Q000378:metabolism*; D055513:Connective Tissue Growth Factor / Q000378:metabolism*; D003880:Dermatology / Q000379:methods; D005347:Fibroblasts / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D012867:Skin / Q000378:metabolism; D015595:Skin Aging; D051785:Smad Proteins / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D051785:Smad Proteins; D016212:Transforming Growth Factor beta; D055513:Connective Tissue Growth Factor; D003094:Collagen