Rhomboid proteases: familiar features in unfamiliar phases.
In this issue of Molecular Cell, Strisovsky et al. (2009) identify a sequence motif underlying cleavage site specificity for the rhomboid proteases. This sheds light on potential mechanisms by which intramembrane-cleaving proteases cleave their substrates.
Amarneh
Bilal
B
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390-9046, USA.
Rawson
Robert B
RB
D020816:Amino Acid Motifs; D006868:Hydrolysis; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D010447:Peptide Hydrolases; D012697:Serine Endopeptidases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D013379:Substrate Specificity / Q000235:genetics
D008565:Membrane Proteins; D010447:Peptide Hydrolases; D012697:Serine Endopeptidases