TLR signalling regulated antigen presentation in dendritic cells.
Recent evidence suggests that TLR signalling in dendritic cells (DCs) transiently enhances antigen endocytosis and autophagy, augments the assembly of key antigen transport and processing systems, qualitatively modulates protein translation and induces a temporary cessation of DC motility. These rapid changes require activation of the MAP kinases, PI3-kinase and downstream signalling pathways and are observed in both myeloid DC and, with variations on the theme, in plasmacytoid DC.
Watts
Colin
C
Division of Cell Biology & Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. c.watts@dundee.ac.uk
West
Michele A
MA
Zaru
Rossana
R
D000818:Animals; D017951:Antigen Presentation; D002465:Cell Movement; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D021381:Protein Transport; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology* / Q000378:metabolism
D051193:Toll-Like Receptors