[The safety analysis of living-related kidney donors in short term after transplantation].
OBJECTIVE
To evaluate the safety of living related donors in short term after transplantation.


METHODS
Two hundred and fifty-one cases of living related donor kidney transplantation from May 2000 to July 2007 were analysed retrospectively. There were 117 male and 134 female aged from 22 to 72 years old, with a mean of 46.6 years old. The indexes were compared including serum creatinine (SCr), creatinine clearance (CCr), glomerular filtration rate (GFR) and quality of life before and after donation. Surgical complications were followed-up.


RESULTS
Donors' SCr was (75.9 +/- 17.2) micromol/L before donation, (107.4 +/- 21.2) micromol/L on 7 d after donation, (130.4 +/- 58.2) micromol/L at the 1(st) month and (116.1 +/- 24.1) micromol/L at the 3(rd) month. There were significant difference between any 2 time points (P < 0.01). CCr was (94.4 +/- 17.5) ml/min before donation and (63.5 +/- 17.8) ml/min on 10 d after donation (P < 0.01). In 62 donors, total GFR was (82.4 +/- 21.8) ml/min before donation. On 10 d after donation, GFR of remaining kidney was (57.4 +/- 14.1) ml/min which was 34.7% higher than GFR of this kidney before donation (42.6 +/- 11.8) ml/min. There was no significant difference in quality of life before living related donors and non-donor populations (P = 0.116). Surgical complications included splenic rupture in 1 case, descending colon rupture in 1 case and wound infection in 5 cases.


CONCLUSIONS
Living donor kidney transplantation is safe for donors, although part of indexes would vary within normal range during the early time after donation.
Zhao
Yu-bo
YB
Organ Transplantation Centre of People's Liberation Army, Second Affiliated Hospital of General Hospital of People's Liberation Army, Beijing 100091, China.
Shi
Bing-yi
BY
Chen
Zheng
Z
Pan
Guang-hui
GH
Liao
De-huai
DH
Fang
Jia-li
JL
Wang
Ke
K
Gao
Zhen-li
ZL
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects*; D011184:Postoperative Period; D012189:Retrospective Studies; D012449:Safety; D055815:Young Adult