Anti-inflammatory effect of Acacia visco extracts in animal models.
The aqueous and organic extracts of Acacia visco Lor. Ap Griseb (Fabaceae) were tested for anti-inflammatory activity in experimental models in rat. Besides, the free-radical scavenging capacity of extracts from A. visco was determined. The extracts revealed anti-inflammatory effect against carrageenan-induced oedema, phospholipase A(2)-induced oedema, cotton pellet-induced granuloma and they did not show acute toxic effect. Among the class of compounds characterized from A. visco leaves, the triterpenoid 20(29)-lupen-3β-ol (lupeol), 12-ursen-3β-ol (α-amyrin) and 12-oleanen-3β-ol (β-amyrin) may be mainly responsible for the pharmacological activities.
Pedernera
Ana María
AM
Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, San Luis, Argentina.
Guardia
Teresita
T
Calderón
Carola Elisa Guardia
CE
Rotelli
Alejandra Ester
AE
de la Rocha
Nadir Ernesto
NE
Saad
José Roberto
JR
Verrilli
María Alejandra Lopez
MA
Aseff
Susana Garcia
SG
Pelzer
Lilian Eugenia
LE
D000045:Acacia; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000633:toxicity; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D006099:Granuloma / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D051379:Mice; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D053978:Pentacyclic Triterpenes / Q000627:therapeutic use*; D054467:Phospholipases A2; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D000094042:Lupanes
D000893:Anti-Inflammatory Agents; D002351:Carrageenan; D009828:Oleanolic Acid; D053978:Pentacyclic Triterpenes; D054467:Phospholipases A2; D010936:Plant Extracts; C036380:beta-amyrin; C010480:lupeol; D000094042:Lupanes