Chemical decay of an antibiotic inverts selection for resistance.
Antibiotics are often unstable and can decay into various compounds with potential biological activities. We found that as tetracycline degrades, the competitive advantage conferred to bacteria by resistance not only diminishes but actually reverses to become a prolonged disadvantage due to the activities of more stable degradation products. Tetracycline decay can lead to net selection against resistance, which may help explain the puzzling coexistence of sensitive and resistant strains in natural environments.
Palmer
Adam C
AC
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.
Angelino
Elaine
E
Kishony
Roy
R
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D007536:Isomerism; D015394:Molecular Structure; D012641:Selection, Genetic; D013752:Tetracycline / Q000737:chemistry* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D013752:Tetracycline