Enzyme-instructed self-assembly of peptide derivatives to form nanofibers and hydrogels.
The review describes the use of enzyme catalysis and self-assembly, two essential and ubiquitous processes in biology, to create molecular nanofibers of peptide derivatives at the supramolecular level as potential nanomedicines and biomaterials. In particular, we discuss the use of enzymes to instruct the self-assembly of small peptide derivatives for hydrogelation, which takes place in vitro or in vivo, extra- or intracellularly, as a new strategy to detect the activity of enzymes, screen enzyme inhibitors, type bacteria, develop drug delivery systems, enhance the activity and stability of enzymes, and control the fate of cells.
Gao
Yuan
Y
Department of Chemistry, Brandeis University, 415 South St, Waltham, MA 02454, USA.
Yang
Zhimou
Z
Kuang
Yi
Y
Ma
Man-Lung
ML
Li
Jiayang
J
Zhao
Fan
F
Xu
Bing
B
D000818:Animals; D001419:Bacteria / Q000378:metabolism; D004795:Enzyme Stability; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D015394:Molecular Structure; D057139:Nanofibers / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D015202:Protein Engineering; D014867:Water / Q000737:chemistry
D004798:Enzymes; D020100:Hydrogels; D010455:Peptides; D014867:Water