Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipids.
Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis. Our aim was to investigate serum levels of ZAG and polymorphisms in the ZAG gene in relation to serum lipids in man. Serum levels of ZAG correlated with serum levels of cholesterol (P = .00088) in healthy subjects and during weight loss (P = .059). The ZAG genotype was associated with total cholesterol (P = .014) and low-density lipoprotein cholesterol (P = .026) in healthy subjects, and the associations were replicated in an additional cohort (P = .0017 and P = .060, respectively). Our data indicate that ZAG plays a role in lipid metabolism.
Olofsson
Louise E
LE
The Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden.
Olsson
Bob
B
Lystig
Theodore
T
Jacobson
Peter
P
Jernås
Margareta
M
Sjöholm
Kajsa
K
Gummesson
Anders
A
Sjöström
Lars
L
Eriksson
Per
P
Hamsten
Anders
A
Hale
Laura P
LP
Thelle
Dag S
DS
Carlsson
Björn
B
Carlsson
Lena M S
LM
D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007118:Immunoassay; D008055:Lipids / Q000097:blood*; D008297:Male; D011110:Polymorphism, Genetic; D029589:Seminal Plasma Proteins / Q000097:blood* / Q000235:genetics*; D000090203:Zn-Alpha-2-Glycoprotein
D008055:Lipids; D029589:Seminal Plasma Proteins; D000090203:Zn-Alpha-2-Glycoprotein