Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder.
Functional and structural alterations of the anterior cingulate cortex (ACC), a key region for emotional and cognitive processing, are associated with borderline personality disorder (BPD). However, the interhemispheric structural connectivity between the left and right ACC and between other prefrontal regions in this condition is unknown. We acquired diffusion-tensor imaging data from 20 healthy women and 19 women with BPD and comorbid attention-deficit hyperactivity disorder (ADHD). Interhemispheric structural connectivity between both sides of the ACC, dorsolateral prefrontal cortices and medial orbitofrontal cortices was assessed by a novel probabilistic diffusion tensor-based fiber tracking method. In the BPD group as compared with healthy controls, we found decreased interhemispheric structural connectivity between both ACCs in fiber tracts that pass through the anterior corpus callosum and connect dorsal areas of the ACCs. Decreased interhemispheric structural connectivity between both ACCs may be a structural correlate of BPD.
Rüsch
Nicolas
N
Department of Psychiatry and Psychotherapy, University of Freiburg, Germany. nicolas.ruesch@uniklinik-freiburg.de
Bracht
Tobias
T
Kreher
Björn W
BW
Schnell
Susanne
S
Glauche
Volkmar
V
Il'yasov
Kamil A
KA
Ebert
Dieter
D
Lieb
Klaus
K
Hennig
Jürgen
J
Saur
Dorothee
D
van Elst
Ludger Tebartz
LT
D000293:Adolescent; D000328:Adult; D001883:Borderline Personality Disorder / Q000473:pathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D003337:Corpus Callosum / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006179:Gyrus Cinguli / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008875:Middle Aged; D009434:Neural Pathways / Q000473:pathology; D055815:Young Adult