Bacterial manipulation of innate immunity to promote infection.
The mammalian innate immune response provides a barrier against invading pathogens. Innate immune mechanisms are used by the host to respond to a range of bacterial pathogens in an acute and conserved fashion. Host cells express pattern recognition receptors that sense pathogen-associated molecular patterns. After detection, an arsenal of antimicrobial mechanisms is deployed to kill bacteria in infected cells. Innate immunity also stimulates antigen-specific responses mediated by the adaptive immune system. In response, pathogens manipulate host defence mechanisms to survive and eventually replicate. This Review focuses on the control of host innate immune responses by pathogenic intracellular bacteria.
Diacovich
Lautaro
L
Centre d'Immunologie de Marseille-Luminy, 1 Aix Marseille Université, Institut National de la Santé et de la Recherche Médicale, U631 and Centre National de la Recherche Scientifique, UMR6102, Marseille, F-13,288, France.
Gorvel
Jean-Pierre
JP
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001419:Bacteria / Q000276:immunology* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007110:Immunity, Active; D007113:Immunity, Innate; D014774:Virulence / Q000276:immunology
D000942:Antigens, Bacterial