[Effects of C-reactive protein on chemotaxis ability of monocytes in vitro].
OBJECTIVE
To investigate the effects of C-reactive protein (CRP) on monocytes chemotaxis ability in vitro.


METHODS
Transwell chemotaxis assay was used to evaluate the changes of chemotactic ability of THP-1 monocytes in each group treated with CRP in different concentration.


RESULTS
CRP increased the number of attracted monocytes in response to MCP-1 (monocyte chemoattractant protein-1). When treated with CRP concentration at 2 microg x mL(-1), the number of chemotactic monocytes increased (P < 0.05). The number of attracted monocytes increased as CRP concentration was elevated (P < 0.05).


CONCLUSIONS
CRP can increase chemotactic ability of THP-1 monocytes in concentration dependent manner.
Meng
Shu
S
State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
Zhang
Lin
L
Yang
He
H
Wu
Ya-Fei
YF
Ge
Song
S
Zhao
Lei
L
D002097:C-Reactive Protein; D018932:Chemokine CCL2; D002633:Chemotaxis; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes
D018932:Chemokine CCL2; D002097:C-Reactive Protein