[Preparation and release in vitro of injectable thermosensitive in situ gel of Glabrous Sarcandra herb extract].
OBJECTIVE
To prepare and evaluate the injectable temperature responsive in situ gel for sustained release of Glabrous Sarcandra Herb extract in vitro.


METHODS
The novel temperature responsive poloxamer 407 was used as the carrier material of Glabrous Sarcandra Herb extract sustained release injection. The release of Glabrous Sarcandra Herb extract from poloxamer 407 based in situ gel in the phosphate buffer (pH 7. 6) was studied at 37 degrees C under agitation. HPLC method was used for the determination of Glabrous Sarcandra Herb extract.


RESULTS
The best prescription was composed of by 16% P-407, 6% P-188, 0.2% HPMC, 0.5% benzil alcohol and 4% (g mL(-1)) Glabrous Sarcandra Herb extract. The optimal gelation temperature was around 33 degrees C. The data of release in vitro were analyzed according to the theoretical model of Korsmeyer-Peppas.


CONCLUSIONS
The preparation method of the injectable thermosensitive in situ gel of Glabrous Sarcandra Herb extract is appropriate. The release in vitro can reach the expecting request.
Chen
Yanjun
Y
Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing, China. ivycyj@163.com
Li
Lu
L
Liu
Huafeng
H
Peng
Bo
B
Jin
Rixian
R
D029624:Ferns / Q000737:chemistry*; D010936:Plant Extracts / Q000032:analysis*; D020442:Poloxamer / Q000737:chemistry*; D013696:Temperature
D010936:Plant Extracts; D020442:Poloxamer