title: Increased ratio of 2nd to 4th digit (2D:4D) in schizophrenia.
abstract: Sex differences in the onset, epidemiology, clinical presentation and neuropathology of schizophrenia suggest that sexual dimorphism in brain development may be relevant to pathogenesis. Sex hormones, in particular testosterone, are considered to be crucial in brain development, but few investigations have examined the potential role of prenatal testosterone in schizophrenia. In this study, we examined a retrospective marker of prenatal testosterone release - 2D:4D finger length ratio (2D:4D), the relative length of 2nd to 4th digit, in 64 Asian patients with schizophrenia and 64 sex-matched controls. No significant difference in mean finger lengths was present, however 2D:4D ratio was significantly different between patients and controls. The effect was primarily seen in males consistent with a 'less masculinised' pattern and hypotheses suggesting that schizophrenia may be associated with an abnormality in prenatal circulating testosterone.
authors.affiliation: Department of Psychology, National University of Singapore, 117570, Singapore. psycsl@nus.edu.sg
authors.forename: Simon Lowes
authors.initials: SL
authors.lastname: Collinson
authors.forename: Matthew
authors.initials: M
authors.lastname: Lim
authors.forename: Jia Hui
authors.initials: JH
authors.lastname: Chaw
authors.forename: Swapna
authors.initials: S
authors.lastname: Verma
authors.forename: Kang
authors.initials: K
authors.lastname: Sim
authors.forename: Attilio
authors.initials: A
authors.lastname: Rapisarda
authors.forename: Siow Ann
authors.initials: SA
authors.lastname: Chong
mesh_terms: D000328:Adult; D044466:Asian People; D049628:Body Size / Q000502:physiology*; D016022:Case-Control Studies; D005260:Female; D005385:Fingers / Q000033:anatomy & histology*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012559:Schizophrenia / Q000473:pathology*; D012737:Sex Factors; D013739:Testosterone / Q000502:physiology; D055815:Young Adult
chemical_list: D013739:Testosterone