[Cardiotoxicity induced by chemo- and radiotherapy].
The authors describe the case of a 55-year old patient, with dyslipidemia as single cardiovascular risk factor, who previously underwent chemo and radiotherapy for Hodgkin lymphoma (stage 2b). The patient developed early coronary atherosclerosis followed by aortic and mitral valve disease and initial constrictive pericarditis. The role of chemo and radiotherapy in the development of cardiovascular disease, in particular valvular and pericardial disease, is discussed.
Srebot
Vera
V
Istituto di Fisiologia Clinica e Fondazione Toscana Gabriele Monasterio, Pisa.
Sbrana
Francesco
F
Maffei
Alessio
A
Solinas
Marco
M
Rovai
Daniele
D
D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D001022:Aortic Valve Insufficiency / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000209:etiology*; D003324:Coronary Artery Disease / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000209:etiology*; D004317:Doxorubicin / Q000009:adverse effects*; D015150:Echocardiography, Doppler; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008944:Mitral Valve Insufficiency / Q000139:chemically induced / Q000209:etiology*; D009367:Neoplasm Staging; D010494:Pericarditis, Constrictive / Q000139:chemically induced / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin