Tyrosine phosphatase SHP-1 in allergic and anaphylactic inflammation.
Protein tyrosine phosphatase SHP-1 is an essential regulatory molecule in many different signaling pathways. The biological importance of SHP-1 is underscored by the motheaten mutant mouse strains with immunological disorders involving multiple organs and by the close association of aberrant SHP-1 expression with several human diseases. Recent studies provided some compelling evidence that supports a role of SHP-1 in regulating mast cell development and function and also in regulating type 2 allergic inflammatory responses in both innate and adaptive immune responses. In this article, we summarize the recent advancement of our understanding of this interesting phosphatase in the important area of allergic inflammation.
Zhu
Zhou
Z
Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, 5501 Hopkins Bayview Circle/1A.2, Baltimore, MD 21224, USA. zzhu@jhmi.edu
Oh
Sun Young
SY
Cho
You Sook
YS
Zhang
Li
L
Kim
Yoon-Keun
YK
Zheng
Tao
T
D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007249:Inflammation; D008168:Lung / Q000276:immunology* / Q000378:metabolism; D008407:Mast Cells / Q000166:cytology; D051379:Mice; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6 / Q000378:metabolism*; D015398:Signal Transduction
D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6