Tissue reaction to implantation of collagen film.
A new modified collagen film was investigated to evaluate the tissue reaction and absorption time (a) after implantation in rabbit muscle, and (b) in a human model where collagen was implanted in the prostatic cavity during operation. Clinical follow-up by cystoscopy and biopsy was made one week postoperatively. The animal results showed that for 6 weeks after implantation there was a cellular reaction associated with phagocytosis of the collagen film. Then a scar was formed, similar to that in the controls. The human results showed a similar tissue reaction and no adverse effects from the collagen film.
Bergqvist
D
D
Department of Surgery, Kärnsjukhuset, Skövde, Uppsala, Sweden.
Falk
J
J
Ståhl
A
A
D000818:Animals; D003094:Collagen / Q000008:administration & dosage*; D006801:Humans; D008954:Models, Biological; D010587:Phagocytosis; D011817:Rabbits
D003094:Collagen