[Coactivators in energy metabolism: peroxisome proliferator-activated receptor-gamma coactivator 1 family].
Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC1) family is highly expressed in tissues with high energy metabolism. They coactivate transcription factors in regulating genes engaged in processes such as gluconeogenesis, adipose beta-oxydation, lipoprotein synthesis and secretion, mitochondrial biogenesis, and oxidative metabolism. Protein conformation studies demonstrated that they lack DNA binding domains and act as coactivators through physical interaction with transcription factors. PGC1 activity is regulated at transcription level or by multiple covalent chemical modifications such as phosphorylation, methylation and acetylation/deacetylation. Abnormal expression of PGC1 coactivators usually is closely correlated with diseases such as diabetes, obesity, hyperglycemia, hyperlipemia, and arterial and brain neuron necrosis diseases.
Wang
Rui
R
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Beijing 100005, China.
Chang
Yong-sheng
YS
Fang
Fu-de
FD
D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D014157:Transcription Factors / Q000378:metabolism*
D014157:Transcription Factors; C111264:peroxisome-proliferator-activated receptor-gamma coactivator-1