title: Comprehensive sequential interventional therapy for hepatocellular carcinoma.
abstract: BACKGROUND
  Since the 1980s, various approaches to interventional therapy have been developed, with the development and achievement of medical imaging technology. This study aimed to evaluate the effectiveness of comprehensive sequential interventional therapy especially personal therapeutic plan in 53 radical cure patients with hepatocellular carcinoma (HCC).
  
  
  METHODS
  From January 2003 to January 2005, a total of 203 patients with HCC received sequential interventional treatment in our hospital. Fifty-three patients achieved radical cure outcomes. Those patients were treated with transcatheter arterial chemoembolization (TACE), radiofrequency ablation (RFA), percutaneous ethanol injection (PEI), or high intensity focused ultrasound (HIFU), sequentially and in combination depending on their clinical and pathological features. PET-CT was used to evaluate, assess, and guide treatment.
  
  
  RESULTS
  Based on the imaging and serological data, all the patients had a personal therapeutic plan. The longest follow-up time was 24 months, the shortest was 6 months, and mean survival time was 16.5 months.
  
  
  CONCLUSIONS
  Comprehensive sequential interventional therapy especially personal therapeutic plan for HCC play roles in interventional treatment of HCC in middle or advanced stage.
authors.affiliation: State Key Laboratory of Oncology in Southern China, Department of Radiology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong 510060, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.forename: Wei-jun
authors.initials: WJ
authors.lastname: Fan
authors.forename: Jin-hua
authors.initials: JH
authors.lastname: Huang
authors.forename: Chuan-xing
authors.initials: CX
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.forename: Li-gang
authors.initials: LG
authors.lastname: Wang
authors.forename: Tian
authors.initials: T
authors.lastname: Tang
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D017115:Catheter Ablation; D016461:Chemoembolization, Therapeutic; D003131:Combined Modality Therapy; D000431:Ethanol / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D014464:Ultrasonic Therapy
chemical_list: D000431:Ethanol