Clonal complex chromosome aberration in non-ossifying fibroma.
Cytogenetic information of non-ossifying fibromas (NOFs) is exceptionally limited. This fact relies, in part, on their benign nature but mainly because most cases evolve undetected or there is no need for surgical intervention. We report the case of a NOF arising in the left tibia of a 14-year-old male with an invariable clonal translocation. The karyotype was denoted as 42-46,XY,t(11;3;14)(q23;p21;p11). There are only two previous reported cases of clonally aberrant NOF. Records from additional cases will be essential to assess whether consistent karyotypic aberrations define this lesion.
Brassesco
María Sol
MS
Department of Pediatrics, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil. marsol@rge.fmrp.usp.br
Valera
Elvis Terci
ET
Engel
Edgard Eduard
EE
Nogueira-Barbosa
Marcello Henrique
MH
Becker
Aline Paixão
AP
Scrideli
Carlos Alberto
CA
Tone
Luiz Gonzaga
LG
D000293:Adolescent; D001859:Bone Neoplasms / Q000235:genetics* / Q000473:pathology; D020732:Cytogenetic Analysis; D005350:Fibroma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D013977:Tibia; D014178:Translocation, Genetic