Microarray blood testing: Pros & cons.
Blood donation screening represents rather a unique set of blood grouping-related and pathogen detection assays. We are confronted with continuously growing numbers of testing targets. Ideally, the spectrum of clinically significant blood group antigens and alloantibodies would be wider than allowed by current routine tests. At the same time, we are witnessing an increase in emerging and re-emerging human pathogens due to urbanisation, increased international travel and trade, climate change and other factors. The spectrum of blood-borne infectious agents requiring donation screening is expected to grow correspondingly. Dengue and chikungunya viruses, variant CJD and hepatitis E virus represent just some of the candidate infectious agents for future donation screening. Multiplexing techniques, such as microarrays are well suited to address the growing number of targets, pending the increase in sensitivity of some of the microarrays assays. There are several possible scenarios for future testing algorithms, combining new multiplexing techniques with the existing blood testing assays. New generation testing platforms capable of microbiology screening, blood grouping and potential additional types of targets, are also being developed.
Petrik
Juraj
J
Scottish National Blood Transfusion Service, TTI Department, 21 Ellen's Glen Road, EH17 7QT Edinburgh, UK. juraj.petrik@nhs.net
D001782:Blood Donors; D017848:Blood-Borne Pathogens / Q000302:isolation & purification; D005838:Genotype; D006403:Hematologic Tests / Q000295:instrumentation / Q000379:methods* / Q000592:standards / Q000639:trends; D006801:Humans; D046228:Microarray Analysis / Q000295:instrumentation / Q000379:methods*; D012680:Sensitivity and Specificity; D012698:Serologic Tests / Q000295:instrumentation / Q000379:methods / Q000592:standards / Q000639:trends