Utilization of myosin and actin bundles for the transport of molecular cargo.
The utilization of motor proteins for the movement and assembly of synthetic components is currently a goal of nanoengineering research. Application of the myosin actin motor system for nanotechnological uses has been hampered due to the low flexural rigidity of individual F-actin filaments. Here it is demonstrated how actin bundling can be used to affect the translational behavior of myosin-propelled filaments, transport molecules across a motor-patterned surface, and that the movement of bundled actin can be regulated photonically. These data suggest that actin bundling may significantly improve the applicability of the myosin motor for future nanotechnological applications.
Takatsuki
Hideyo
H
Laboratory of Molecular Physiology, Robert C. Byrd Biotechnology Science Center, Department of Biological Sciences, Marshall University, Huntington, WV 25755-1090, USA.
Rice
Kevin M
KM
Asano
Shinichi
S
Day
B Scott
BS
Hino
Mizuki
M
Oiwa
Kazuhiro
K
Ishikawa
Ryoki
R
Hiratsuka
Yuichi
Y
Uyeda
Taro Q P
TQ
Kohama
Kazuhiro
K
Blough
Eric R
ER
D008841:Actin Cytoskeleton / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D000199:Actins / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects / Q000528:radiation effects; D002645:Chickens; D006576:Heterocyclic Compounds, 4 or More Rings / Q000494:pharmacology; D006801:Humans; D008027:Light; D009218:Myosins / Q000378:metabolism*; D053758:Nanoparticles / Q000737:chemistry; D011817:Rabbits
D000199:Actins; D006576:Heterocyclic Compounds, 4 or More Rings; C472645:blebbistatin; D009218:Myosins