title: Cardioprotection in ischemia/reperfusion injury: spotlight on sphingosine-1-phosphate and bradykinin signalling.
abstract: Complex signal-transduction cascades are known to be involved in regulating cardiomyocyte function, death and survival during acute cardiac ischemia-reperfusion process, but detailed survival signalling pathways are not clear. This review presents and discusses the recent findings bearing upon the evidence on the cardioprotective effect of sphingosine-1-phosphate (S1P) and bradykinin in acute cardiac ischemia-reperfusion and underlying signalling mechanisms, particularly, through activation of P21 activated kinase.
authors.affiliation: Victoria Hospital, Cardiology, Hayfield Road, Kirkcaldy, Fife KY2 5AH, UK.
authors.forename: Emmanuel Eroume A
authors.initials: EE
authors.lastname: Egom
authors.forename: Yunbo
authors.initials: Y
authors.lastname: Ke
authors.forename: R John
authors.initials: RJ
authors.lastname: Solaro
authors.forename: Ming
authors.initials: M
authors.lastname: Lei
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008246:Lysophospholipids / Q000494:pharmacology / Q000627:therapeutic use*; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control*; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D054462:p21-Activated Kinases / Q000378:metabolism
chemical_list: D008246:Lysophospholipids; C060506:sphingosine 1-phosphate; D054462:p21-Activated Kinases; D013110:Sphingosine; D001920:Bradykinin