The potential benefits of low-molecular-weight heparins in cancer patients.
Cancer patients are at increased risk of venous thromboembolism due to a range of factors directly related to their disease and its treatment. Given the high incidence of post-surgical venous thromboembolism in cancer patients and the poor outcomes associated with its development, thromboprophylaxis is warranted. A number of evidence-based guidelines delineate anticoagulation regimens for venous thromboembolism treatment, primary and secondary prophylaxis, and long-term anticoagulation in cancer patients. However, many give equal weight to several different drugs and do not make specific recommendations regarding duration of therapy. In terms of their efficacy and safety profiles, practicality of use, and cost-effectiveness the low-molecular-weight heparins are at least comparable to, and offer several advantages over, other available antithrombotics in cancer patients. In addition, data are emerging that the antithrombotics, and particularly low-molecular-weight heparins, may exert an antitumor effect which could contribute to improved survival in cancer patients when given for long-term prophylaxis. Such findings reinforce the importance of thromboprophylaxis with low-molecular-weight heparin in cancer patients.
Robert
Francisco
F
Department of Medicine, Division of Hematology/Oncology, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 352943300, USA. pacorobertuab@cs.com
D000925:Anticoagulants / Q000737:chemistry / Q000191:economics / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D006493:Heparin / Q000009:adverse effects / Q000737:chemistry / Q000191:economics / Q000627:therapeutic use*; D006801:Humans; D008970:Molecular Weight; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D011315:Preventive Medicine / Q000191:economics / Q000639:trends; D018570:Risk Assessment; D016019:Survival Analysis; D054556:Venous Thromboembolism / Q000150:complications / Q000517:prevention & control*
D000925:Anticoagulants; D006493:Heparin