title: Inhibitory effect of proanthocyanidin on ultraviolet B irradiation-induced melanogenesis.
abstract: Repetitive exposure of the skin to ultraviolet (UV) radiation induces various adverse effects, including skin thickening, wrinkle formation, inflammation, and pigmentation. Various natural and synthetic compounds were studied to determine whether they might prevent UV induction of these adverse effects. In particular, naturally occurring antioxidants were used for regulating skin damage induced by UV radiation since several antioxidants were found to inhibit photoaging through prevention of collagen synthesis via inhibition of matrix metalloproteinases (MMP) and/or decrease of melanin synthesis. The L values in pigmented skin were lower at 4 wk (52.97 +/- 2.09) than at the start of this study (0 wk, 62.89 +/- 0.56) in the control. In the proanthocyanidin mixture group, the L value was increased (56.83 +/- 1.71) similar to the control (52.97 +/- 2.09). Proanthocyanidin also suppressed the expression levels of tyrosinase by 20-40%, and blocked the expression of MITF, TRP-1, and TRP-2, which are factors implicated in the control of melanogenesis. Taken together, these data indicate that proanthocyanidin may be useful to attenuate UVB-induced melanogenesis.
authors.affiliation: College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Republic of Korea.
authors.forename: Ho-Song
authors.initials: HS
authors.lastname: Cho
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Kwak
authors.forename: Im Seup
authors.initials: IS
authors.lastname: Choi
authors.forename: Hyung Kook
authors.initials: HK
authors.lastname: Park
authors.forename: Sang Jin
authors.initials: SJ
authors.lastname: Kang
authors.forename: Hwan Soo
authors.initials: HS
authors.lastname: Yoo
authors.forename: Moon Soon
authors.initials: MS
authors.lastname: Lee
authors.forename: Ki-Won
authors.initials: KW
authors.lastname: Oh
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
mesh_terms: D000363:Agaricales / Q000201:enzymology; D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008543:Melanins / Q000378:metabolism*; D008545:Melanoma; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D010858:Pigmentation / Q000187:drug effects* / Q000528:radiation effects; D044945:Proanthocyanidins / Q000494:pharmacology*; D014466:Ultraviolet Rays
chemical_list: D008543:Melanins; D044945:Proanthocyanidins; C013221:proanthocyanidin; D014442:Monophenol Monooxygenase