title: Gas in portal circulation and pneumatosis cystoides intestinalis during chemotherapy for advanced rectal cancer.
abstract: OBJECTIVE
  Acute abdominal symptoms with CT scan evidence of intramural gas in bowel walls (pneumatosis cystoides intestinalis, PCI) and of gas in the portal venous blood (PBG) in patients undergoing chemotherapy may represent a worrisome picture, suggestive of bowel necrosis. This picture remains a major clinical clue and the reporting of new cases may help to share awareness and experience on management. We describe a patient with acute abdominal symptoms and evidence of PCI with PBG under cetuximab, oxaliplatin, tegafur-uracil and folinic acid chemotherapy for metastatic adenocarcinoma of the rectosigmoid junction.
  
  
  METHODS
  After admission for mucositis with diarrhea and profound dehydration, and subsequent emergency laparotomy for derotation of an intestinal volvulus, on the tenth postoperative day the patient developed fever and abdominal pain, with CT scan evidence of PCI with PBG. The exam of the abdomen did not suggest major problems requiring emergency surgery, and antibiotic treatment with close monitoring were performed, followed by rapid improvement.
  
  
  RESULTS
  Twelve days later, after resumption of oral diet, the patient unexpectedly suffered a spontaneous jejunal microperforation, requiring emergency laparotomy and bowel resection. Pathology showed that the perforation was within an area of ulceration involving the inner superficial layer of the bowel. Subsequently recovery was normal and at present, after 15 months, the patient is well and continuing chemotherapy.
  
  
  CONCLUSIONS
  This is probably the first report of PCI with PBG related to intestinal toxicity during cetuximab, oxaliplatin, tegafur-uracil and folinic acid chemotherapy in a patient with advanced rectal carcinoma, followed by delayed small bowel perforation. It provides an example of the challenges involved in the management of this type of patient.
authors.affiliation: Catholic University of Sacred Heart, Agostino Gemelli Medical School, Rome, Italy. gclemente@rm.unicatt.it
authors.forename: G
authors.initials: G
authors.lastname: Clemente
authors.forename: C
authors.initials: C
authors.lastname: Chiarla
authors.forename: I
authors.initials: I
authors.lastname: Giovannini
authors.forename: A M
authors.initials: AM
authors.lastname: De Rose
authors.forename: A
authors.initials: A
authors.lastname: Astone
authors.forename: C
authors.initials: C
authors.lastname: Barone
authors.forename: G
authors.initials: G
authors.lastname: Nuzzo
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000009:adverse effects; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D000068818:Cetuximab; D005740:Gases; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects; D000077150:Oxaliplatin; D011006:Pneumatosis Cystoides Intestinalis / Q000139:chemically induced / Q000473:pathology / Q000601:surgery; D011169:Portal Vein / Q000473:pathology*; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000473:pathology; D005641:Tegafur / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D005740:Gases; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D005641:Tegafur; D000068818:Cetuximab; D002955:Leucovorin