Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes.
Guanidino-modified phthalocyanines are evaluated in vitro (polymerase-stop assays and FRET) and in cultured cells as G4-DNA ligands and modulators of gene transcription.
Membrino
Alexandro
A
Department of Biomedical Science and Technology, University of Udine, 33100 Udine, Italy.
Paramasivam
Manikandan
M
Cogoi
Susanna
S
Alzeer
Jawad
J
Luedtke
Nathan W
NW
Xodo
Luigi E
LE
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002463:Cell Membrane Permeability; D004247:DNA / Q000235:genetics; D054856:G-Quadruplexes / Q000187:drug effects*; D019791:Guanidine / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D054833:Isoindoles; D051379:Mice; D041681:NIH 3T3 Cells; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects*
D000970:Antineoplastic Agents; D007211:Indoles; D054833:Isoindoles; D004247:DNA; D016283:Proto-Oncogene Proteins p21(ras); D019791:Guanidine; C013647:phthalocyanine