Periodontitis and abdominal aortic aneurysms: a random association or a pathogenetic link?
A number of micro-organisms have been implicated in the development/progression of abdominal aortic aneurysms (AAAs), thus suggesting an infective theory of AAA pathogenesis. Periodontitis may be involved in the development of AAAs by means of introduction of subgingival plaque periodontal bacteria into the bloodstream and degeneration of the aortic wall. A different theory supports that the findings of periodontal pathogens in AAA biopsies are a secondary phenomenon with transient bacteremia leading to invasion of already formed AAAs. It is not yet clear whether the periodontopathic bacteria accelerate the growth/weakening of the aortic wall or whether they are secondary colonizers of AAAs. Clarification of the association between periodontal disease and AAAs in large-scale studies holds implications for a role for chemoprophylaxis/antibiotic treatment in the management of AAAs.
Paraskevas
K I
KI
Department of Vascular Surgery, Red Cross Hospital, Athens, Greece.
Mikhailidis
D P
DP
Giannoukas
A D
AD
D000785:Aneurysm, Infected / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017544:Aortic Aneurysm, Abdominal / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D019317:Evidence-Based Medicine; D006801:Humans; D010518:Periodontitis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D018570:Risk Assessment; D012307:Risk Factors
D000900:Anti-Bacterial Agents