title: Targeted magnetic liposomes loaded with doxorubicin.
abstract: Targeted delivery systems for anticancer drugs are urgently needed to achieve maximum therapeutic efficacy by site-specific accumulation and thereby minimizing adverse effects resulting from systemic distribution of many potent anticancer drugs. We have prepared folate receptor targeted magnetic liposomes loaded with doxorubicin, which are designed for tumor targeting through a combination of magnetic and biological targeting. Furthermore, these liposomes are designed for hyperthermia-induced drug release to be mediated by an alternating magnetic field and to be traceable by magnetic resonance imaging (MRI). Here, detailed preparation and relevant characterization techniques of targeted magnetic liposomes encapsulating doxorubicin are described.
authors.affiliation: School of Biosciences and Bioengineering, IIT Bombay, Mumbai, India.
authors.forename: Pallab
authors.initials: P
authors.lastname: Pradhan
authors.forename: Rinti
authors.initials: R
authors.lastname: Banerjee
authors.forename: Dhirendra
authors.initials: D
authors.lastname: Bahadur
authors.forename: Christian
authors.initials: C
authors.lastname: Koch
authors.forename: Olga
authors.initials: O
authors.lastname: Mykhaylyk
authors.forename: Christian
authors.initials: C
authors.lastname: Plank
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D002352:Carrier Proteins / Q000378:metabolism*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D058973:Folate Receptors, GPI-Anchored; D005492:Folic Acid / Q000737:chemistry / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D007501:Iron / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D008280:Magnetics; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013696:Temperature
chemical_list: D000903:Antibiotics, Antineoplastic; D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D008081:Liposomes; D011956:Receptors, Cell Surface; D004317:Doxorubicin; D005492:Folic Acid; D007501:Iron