title: B-type natriuretic peptide utilization as an adjunct to management in a case of conjoined twins with pulmonary hypertension.
abstract: This article reports a case of pulmonary hypertension in 37-week-gestational-age, pygopagus conjoined twins where B-type natriuretic peptide (BNP) was used as a cost-effective and important tool to aid effective management. Pulmonary hypertension in neonates is associated with high morbidity and mortality and multiplies the challenge of caring for conjoined twins. BNP is a peptide hormone secreted by cardiac ventricles that have undergone stress related to ventricular filling, volume overload, and pressure. BNP is commonly used in adults to assess heart failure, but its utility is less established in infants receiving neonatal intensive care. In this case, BNP testing was used as an adjunct to standard assessments for rapid diagnosis which was critical to expediting appropriate treatment management for these high-risk patients.
authors.affiliation: David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Vladana
authors.initials: V
authors.lastname: Milisavljevic
authors.forename: Isabell B
authors.initials: IB
authors.lastname: Purdy
authors.forename: Cindy
authors.initials: C
authors.lastname: Le
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D004200:Diseases in Twins / Q000378:metabolism* / Q000628:therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000378:metabolism* / Q000628:therapy*; D007223:Infant; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D016896:Treatment Outcome; D014428:Twins, Conjoined; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D015415:Biomarkers; D014662:Vasoconstrictor Agents; D020097:Natriuretic Peptide, Brain