title: Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease.
abstract: BACKGROUND
  A reduction in dietary saturated fat has generally been thought to improve cardiovascular health.
  
  
  OBJECTIVE
  The objective of this meta-analysis was to summarize the evidence related to the association of dietary saturated fat with risk of coronary heart disease (CHD), stroke, and cardiovascular disease (CVD; CHD inclusive of stroke) in prospective epidemiologic studies.
  
  
  METHODS
  Twenty-one studies identified by searching MEDLINE and EMBASE databases and secondary referencing qualified for inclusion in this study. A random-effects model was used to derive composite relative risk estimates for CHD, stroke, and CVD.
  
  
  RESULTS
  During 5-23 y of follow-up of 347,747 subjects, 11,006 developed CHD or stroke. Intake of saturated fat was not associated with an increased risk of CHD, stroke, or CVD. The pooled relative risk estimates that compared extreme quantiles of saturated fat intake were 1.07 (95% CI: 0.96, 1.19; P = 0.22) for CHD, 0.81 (95% CI: 0.62, 1.05; P = 0.11) for stroke, and 1.00 (95% CI: 0.89, 1.11; P = 0.95) for CVD. Consideration of age, sex, and study quality did not change the results.
  
  
  CONCLUSIONS
  A meta-analysis of prospective epidemiologic studies showed that there is no significant evidence for concluding that dietary saturated fat is associated with an increased risk of CHD or CVD. More data are needed to elucidate whether CVD risks are likely to be influenced by the specific nutrients used to replace saturated fat.
authors.affiliation: Children's Hospital, Oakland Research Institute Oakland, CA, USA.
authors.forename: Patty W
authors.initials: PW
authors.lastname: Siri-Tarino
authors.forename: Qi
authors.initials: Q
authors.lastname: Sun
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Krauss
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D015331:Cohort Studies; D003327:Coronary Disease / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D004032:Diet / Q000009:adverse effects; D004041:Dietary Fats / Q000009:adverse effects*; D005227:Fatty Acids / Q000009:adverse effects*; D006801:Humans; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids