title: [Evaluation of the analgesic effects of the lumiracoxib compared with placebo in the 24 first postoperative hours].
abstract: OBJECTIVE
  To test lumiracoxib used preemptively against a placebo,and to analyse the analgesic administration (dipirona and tramadol) in the 24 first postoperative hours.
  
  
  METHODS
  Sixty patients undergone to a breast aumentation, under epidural anesthesia, were selected and put randomly in two groups - GI and GII. Sixty minutes before the surgery, it was administered orally, one pill of lumiracoxib 400mg to the 30 GI patients and one pill of placebo to the 30 GII patients. The postoperative pain was evaluated through the visual analogic scale, ranged from 0 (painless) to 10 (most intensive pain), being applied to the patient whenever having pain. For the same scores or under 4, it was administered intravenously 15mg/kg of dipirona up to a maximum of 1g. For scores of 5, 6 or 7, the patient had intravenously 50mg of tramadol.Scores 8 or more were treated intravenously with 0,5 mg/kg of meperidine.
  
  
  RESULTS
  The scores in GI were significantly lower than the ones obtained in GII within the first 24 hours, with the need of 20% less dipirona and 56% of tramadol in this period of time. In the same way, it was observed that analgesic solicitation for the first time had a delay of 191 minutes in GI in comparison to GII.
  
  
  CONCLUSIONS
  The use of lumiracoxib preemptively, was effective in the treatment of postoperative pain, reducing considerably the consume of analgesics, and enlarging the time for the first medication.
authors.affiliation: Facudade de Medicina, Universidade de Caxias do Sul, Caxias do Sul, RS, Brasil.
authors.forename: Vilmar
authors.initials: V
authors.lastname: Molon
authors.forename: Cleber Dario Pinto
authors.initials: CD
authors.lastname: Kruel
authors.forename: Desiré Tarso
authors.initials: DT
authors.lastname: Maioli
authors.forename: Juliana Zanrosso
authors.initials: JZ
authors.lastname: Caran
authors.forename: Raquel Cristina
authors.initials: RC
authors.lastname: Lovison
mesh_terms: D000328:Adult; D000698:Analgesia; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage; D004008:Diclofenac / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004177:Dipyrone / Q000008:administration & dosage; D005260:Female; D006801:Humans; D010149:Postoperative Pain / Q000517:prevention & control*; D013997:Time Factors; D014147:Tramadol / Q000008:administration & dosage
chemical_list: D000701:Analgesics, Opioid; D000806:Angiotensin-Converting Enzyme Inhibitors; D004008:Diclofenac; D014147:Tramadol; D004177:Dipyrone; C473384:lumiracoxib