Copper-free cycloaddition of azide and alkyne in crystalline state facilitated by arene-perfluoroarene interactions.
Facilitated by arene-perfluoroarene interactions, a 1,3-dipolar cycloaddition between azide and alkyne proceeded in the crystals at room temperature in the absence of a copper(I) catalyst, and the reaction was confirmed to be a highly regioselective process giving the 1,4-triazole product.
Ni
Ben-Bo
BB
Beijing National Laboratory for Molecular Sciences (BNLMS), Key Labs of Polymer Chemistry & Physics of Ministry of Education, College of Chemistry, Peking University, Beijing, 100871, China.
Wang
Chong
C
Wu
Huixian
H
Pei
Jian
J
Ma
Yuguo
Y
D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000480:Alkynes; D001386:Azides; D014230:Triazoles