Novel rat model of stress urinary incontinence with a retroflexed bladder.
OBJECTIVE
We created a rat model with a retroflexed bladder that mimicked the loss of the posterior urethrovesical angle and compared the results with sham-surgery rats for the establishment of rat models of stress urinary incontinence.


METHODS
The retroflexed bladder was created by stitching the bladder posteriorly to the psoas muscle. Sneeze-induced urethral pressure response and urethral baseline pressure were measured using a microtip-transducer catheter and leak point pressures induced by sneezing, the Crede maneuver, and the vertical tilt table method were measured via a supra-pubic cystostomy.


RESULTS
In rats with a retroflexed bladder, both urethral pressure response and sneeze-induced leak point pressure were significantly decreased.


CONCLUSIONS
A retroflexed bladder may cause stress urinary incontinence by attenuating the sneeze-induced active urethral closure mechanism. Urethral pressure response restored by resumption of the posterior urethrovesical angle would explain why no sling tension is needed to treat the stress urinary incontinence.
Kawamorita
Naoki
N
Department of Urology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan.
Kaiho
Yasuhiro
Y
Nakagawa
Haruo
H
Miyazato
Minoru
M
Matsushita
Mabumi
M
Arai
Yoichi
Y
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D011312:Pressure; D051381:Rats; D017207:Rats, Sprague-Dawley; D001743:Urinary Bladder / Q000002:abnormalities; D014550:Urinary Incontinence, Stress / Q000209:etiology