title: Dynamic epidemiology of acute viral hepatitis in Japan.
abstract: The epidemiology of acute viral hepatitis (AVH) is dynamic and affected by many factors including hygiene, socioeconomic status and vaccination coverage. A total of 4,302 cases of AVH were sequentially enrolled in this nationwide study between 1980 and 2008. Of the cases of AVH, acute hepatitis A (AHA) accounted for 1,583 (36.8%), acute hepatitis B (AHB) for 1,197 (27.8%), acute hepatitis C (AHC) for 359 (8.3%), and non-A, non-B and non-C (non-ABC) for 1,163 (27.0%). Between 1980 and 1995, the proportions of AHA, AHB, AHC and non-ABC were approximately 40, 25, 10 and 25%; between 1996 and 2003, they were approximately 30, 30, 10 and 30%, and this shifted to approximately 10, 40, 10 and 40% in the last 5 years. The number of AHB caused by genotype A, which is not indigenous to Japan, was 6.0% between 1991 and 1996 but has been markedly increasing since 2000, to reach 52% in 2008. Autochthonous acute hepatitis E (AHE) accounted for 10-15% of non-ABC hepatitis after 2002. The etiology of AVH in Japan has been drastically changing. A marked increase of AHB genotype A and constant occurrence of autochthonous AHE require attention, and necessary measures should be taken.
authors.affiliation: Research Center for Hepatitis and Immunology, International Medical Center of Japan, Kohnodai Hospital, Ichikawa, Chiba, Japan. kyano-kkr@umin.ac.jp
authors.forename: Koji
authors.initials: K
authors.lastname: Yano
authors.forename: Yoko
authors.initials: Y
authors.lastname: Tamada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yatsuhashi
authors.forename: Atsumasa
authors.initials: A
authors.lastname: Komori
authors.forename: Seigo
authors.initials: S
authors.lastname: Abiru
authors.forename: Kiyoaki
authors.initials: K
authors.lastname: Ito
authors.forename: Naohiko
authors.initials: N
authors.lastname: Masaki
authors.forename: Masashi
authors.initials: M
authors.lastname: Mizokami
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ishibashi
mesh_terms: D006518:Hepatitis Viruses / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006525:Hepatitis, Viral, Human / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D015995:Prevalence