title: Models for the generation and interpretation of gradients.
abstract: Source regions for morphogen gradients-organizing regions-can be generated if a local self-enhancing reaction is coupled with a long-ranging reaction that acts antagonistically. Resulting gradients can be translated into patterns of stable gene activities using genes whose products have a positive feedback on the activation on themselves. If several autoregulatory genes compete with each other for activity, cells make an unequivocal choice. Although the signal consists of a smoothly graded distribution, the all-or-nothing response of the cells leads to regions of differently determined cells that are delimited by sharp borders. In some systems, it is not the absolute but the relative level of a gradient that matters. The sequence of head, tentacles, and foot formation in hydra is controlled by a head activation gradient and is an example of this widely used but conceptually rather neglected mode. For subpatterns such as legs and wings, different "compartments" cooperate to produce new signaling substances. Here, morphogen production is restricted to the common borders or where they intersect. The model accounts for the formation of substructures in pairs at the correct positions within the embryo and for the correct orientation and handedness with respect to the main body axes.
authors.affiliation: Max-Planck-Institut für Entwicklungsbiologie, Spemannstr. 35, D- 72076 Tübingen. hans.meinhardt@tuebingen.mpg.de
authors.forename: Hans
authors.initials: H
authors.lastname: Meinhardt
mesh_terms: D000818:Animals; D019521:Body Patterning; D015509:Developmental Biology / Q000379:methods*; D005121:Extremities / Q000473:pathology; D018507:Gene Expression Regulation, Developmental; D006257:Head / Q000196:embryology / Q000502:physiology; D006829:Hydra / Q000196:embryology* / Q000502:physiology*; D008954:Models, Biological; D008957:Models, Genetic; D009024:Morphogenesis; D012038:Regeneration; D015398:Signal Transduction