[Effect of botulinum toxin-A on secretion of parasympathetic denervated rabbit submandibular gland].
OBJECTIVE
To investigate the effect of botulinum toxin-A (BTX-A) on secretion of parasympathetic denervated rabbit submandibular gland.


METHODS
Twenty-four rabbits were divided into 3 groups: control (n = 4), parasympathetic denervated submandibular gland (n = 4), and parasympathetic denervated submandibular gland with 5 U BTX-A injection (n = 16). Secretion flow was measured by Schirmer test. Composition of saliva was detected by biochemical method.


RESULTS
Secretion of parasympathetic denervated submandibular gland increased by 139.0% in rest time (P < 0.01), but decreased by 64.2% in feeding time (P < 0.01) compared with controls. Secretion of submandibular gland decreased in rest time 1, 2, 4, and 12 weeks after BTX-A injection compared with that of parasympathetic denervated submandibular gland without injection (P < 0.05), which was also the same in feeding time 1 and 2 week after injection (P < 0.05). The concentrations of amylase, sodium, potassium, chloride and protein of saliva were not changed after BTX-A injection.


CONCLUSIONS
BTX-A could decrease the secretion of parasympathetic denervated submandibular gland.
Shan
Xiao-feng
XF
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Cai
Zhi-gang
ZG
Wu
Li-ling
LL
Yu
Guang-yan
GY
D000818:Animals; D019274:Botulinum Toxins, Type A / Q000494:pharmacology*; D003714:Denervation; D008297:Male; D011817:Rabbits; D012463:Saliva / Q000378:metabolism*; D013363:Submandibular Gland / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism
D019274:Botulinum Toxins, Type A