Postconditioning: from experimental proof to clinical concept.
The therapeutic strategies for acute myocardial infarction in the last decade have, among other therapeutic targets, focused on myocardial reperfusion injury, which accounts for a significant part of the final infarct size. Although several experiments in the last 20 years have reported that pharmacological interventions at reperfusion might reduce myocardial reperfusion injury, this could not be consistently confirmed in animal models or human studies. An alternative to chemical modifiers, postconditioning (brief repeated periods of ischemia applied at the onset of reperfusion) is the first method proven to be efficient in different animal models and to be confirmed in a recent human study. This simple method, applied in the first minute of reperfusion, reduces the final infarct size by 30-50%. This review will focus on the postconditioning technique and show how the data from different animal models and experimental settings have advanced our understanding of both the mechanisms and the definition of an accurate protocol that is easily applicable in human patients in the setting of acute myocardial infarction.
Mewton
Nathan
N
Hôpital Cardiovasculaire Louis Pradel, 28 Avenue Doyen Lépine, Bron 69677, France. nmewton@gmail.com
Ivanès
Fabrice
F
Cour
Martin
M
Ovize
Michel
M
D000818:Animals; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000473:pathology / Q000628:therapy*; D057170:Translational Research, Biomedical