Reticulone, a novel free radical scavenger produced by Aspergillus sp.
Bioassay-guided fractionation of the culture broth of Aspergillus sp. FN070449 (KCTC 26428) using a DPPH (2,2-diphenyl-1-picrylhydrazyl) assay led to the isolation of two compounds: reticulone (1) and reticulol (2). Their chemical structures were elucidated on the basis of UV, IR, NMR, and MS spectroscopic analysis. Compound 1 exhibited more potent free radical scavenging activity on ABTS.+ (2,2'-azino-bis [3-ethylbenzthiazoline-6-sulphonic acid]) and DPPH radicals than did butylated hydroxyanisole (BHA) and caffeic acid.
Ryoo
In-Ja
IJ
Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea.
Xu
Guang-Hua
GH
Kim
Young-Hee
YH
Choo
Soo-Jin
SJ
Ahn
Jong-Seog
JS
Bae
KiHwan
K
Yoo
Ick-Dong
ID
D001230:Aspergillus / Q000378:metabolism*; D001547:Benzaldehydes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D052160:Benzothiazoles / Q000378:metabolism; D001713:Biphenyl Compounds / Q000737:chemistry; D002083:Butylated Hydroxyanisole / Q000378:metabolism; D002109:Caffeic Acids / Q000378:metabolism; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D007218:Industrial Microbiology; D049934:Isocoumarins; D009682:Magnetic Resonance Spectroscopy; D018384:Oxidative Stress; D010851:Picrates / Q000737:chemistry; D013451:Sulfonic Acids / Q000378:metabolism
D001547:Benzaldehydes; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D002109:Caffeic Acids; D003374:Coumarins; D016166:Free Radical Scavengers; D049934:Isocoumarins; D010851:Picrates; D013451:Sulfonic Acids; C549599:reticulone; D002083:Butylated Hydroxyanisole; C010780:reticulol; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl; C040048:caffeic acid