title: [Therapeutic effect of anti-anaphylaxis granule on chronic urticaria and its impact on serum levels of RANTES].
abstract: OBJECTIVE
  To investigate the therapeutic effect of Anti-anaphylaxis Granule (AAG) on chronic urticaria and its impact on cytokine of regulated upon activation of normal T cells expressed and secreted (RANTES), eosinophil chemotactic factor (Eotaxin) and tumor necrosis factor-alpha (TNF-alpha).
  
  
  METHODS
  The therapeutic effects of AAG and cetirizine on chronic urticaria patients allocated in two groups were observed respectively, and the serum levels of RANTES, Eotaxin and TNF-alpha in patients were measured by ELISA before and after treatment, and were compared with those in normal subjects.
  
  
  RESULTS
  The therapeutic effects of AAG group were better in effective rate (88.5% vs 64.0%) and lower in the recurrent rate (5.6% vs 41.9%) than those cetirizine (all P<0.05). Serum levels of RANTES, Eotaxin and TNF-alpha in patients were higher than those in normal subjects (P<0.01), and they could be significantly reduced after AAG treatment (P<0.01).
  
  
  CONCLUSIONS
  AAG has favorite effect for treatment of chronic urticaria, its regulation on serum levels of RANTES, Eotaxin and TNF-alpha may be the mechanism of action.
authors.affiliation: Department of Pharmacology, Weifang Medical University, Shandong, China. shilih@163.com
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Shi
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Fang
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D017332:Cetirizine / Q000627:therapeutic use; D054413:Chemokine CCL11 / Q000097:blood; D018946:Chemokine CCL5 / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D044967:Serum / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014581:Urticaria / Q000097:blood* / Q000188:drug therapy*; D055815:Young Adult
chemical_list: C483024:CCL5 protein, human; D054413:Chemokine CCL11; D018946:Chemokine CCL5; D004365:Drugs, Chinese Herbal; D014409:Tumor Necrosis Factor-alpha; D017332:Cetirizine