Incidence of secondary hyperparathyroidism among postmenopausal women with end-stage knee osteoarthritis.
OBJECTIVE
To evaluate the incidence of secondary hyperparathyroidism (SH) among postmenopausal women with end-stage knee osteoarthritis scheduled for total knee replacement (TKR).


METHODS
283 Caucasian postmenopausal women aged 49 to 81 (mean, 70) years with end-stage idiopathic knee osteoarthritis were scheduled to undergo primary TKR. They had been menopausal for 7 to 31 (mean, 19) years. Their preoperative serum levels of intact parathyroid hormone (I-PTH), calcium, phosphorus, creatinine, and the clearance of creatinine were evaluated.


RESULTS
100 patients had abnormally elevated serum I-PTH. The overall incidence of SH was 35%. Serum levels of calcium and phosphorus were elevated in 33 and 12 patients, respectively. The serum level of I-PTH correlated positively with patient age (r=0.158, p=0.008) and serum creatinine level (r=0.138, p=0.021) and negatively with clearance of creatinine (r= -0.169, p=0.004).


CONCLUSIONS
SH is common among elderly postmenopausal women and may affect bone healing and implant fixation. Preoperative screening/evaluation of the serum PTH level in postmenopausal women scheduled for TKR is recommended.
Papavasiliou
Kyriakos A
KA
3rd Orthopaedic Department, Medical School of the Aristotle University of Thessaloniki, Greece. Kyrpap2005@yahoo.com
Kenanidis
Eustathios I
EI
Potoupnis
Michael E
ME
Sarris
Ioannis K
IK
Kirkos
John M
JM
Kapetanos
George A
GA
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000453:epidemiology*; D015994:Incidence; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000453:epidemiology* / Q000601:surgery; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D017698:Postmenopause; D012044:Regression Analysis; D014945:Wound Healing
D015415:Biomarkers; D010281:Parathyroid Hormone; D010758:Phosphorus; D003404:Creatinine; D002118:Calcium