title: Influence of a magnesium-fluoride coating of magnesium-based implants (MgCa0.8) on degradation in a rabbit model.
abstract: MgCa0.8 cylinders (2.5 x 25 mm(2)) were coated with a magnesium-fluoride layer and implanted in the marrow cavities of both tibiae of 10 New Zealand White rabbits. The implantation duration was 3 and 6 months. The implants were clinically well tolerated. Micro-computed tomography revealed a new bone formation at the edges of the implants as well as an endosteal and periosteal remodeling. Using EDX-analysis, a calcium and phosphorus rich degradation layer could be found on the implant surface. It was covered by an incomplete layer containing fluoride. The analysis by weight before implantation and after 3 and 6 months, respectively, showed a slight decrease in volume in comparison to uncoated implants. When compared with uncoated implants, the mechanical properties of the coated implants exhibited a reduction in strength after 3 months. After 6 months, the strength of the coated implants was higher than that of uncoated cylinders.
authors.affiliation: Small Animal Clinic, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, Hannover 30173, Germany. martina.thomann@tiho-hannover.de
authors.forename: Martina
authors.initials: M
authors.lastname: Thomann
authors.forename: Christian
authors.initials: C
authors.lastname: Krause
authors.forename: Nina
authors.initials: N
authors.lastname: Angrisani
authors.forename: Dirk
authors.initials: D
authors.lastname: Bormann
authors.forename: Thomas
authors.initials: T
authors.lastname: Hassel
authors.forename: Henning
authors.initials: H
authors.lastname: Windhagen
authors.forename: Andrea
authors.initials: A
authors.lastname: Meyer-Lindenberg
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry; D002118:Calcium / Q000737:chemistry; D005260:Female; D005459:Fluorides / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry; D017616:Magnesium Compounds / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning / Q000379:methods; D016348:Osseointegration; D019736:Prostheses and Implants; D011817:Rabbits; D013314:Stress, Mechanical; D013977:Tibia / Q000473:pathology; D013997:Time Factors; D055114:X-Ray Microtomography / Q000379:methods
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D017616:Magnesium Compounds; C031288:magnesium fluoride; D008274:Magnesium; D005459:Fluorides; D002118:Calcium