Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice.
This study investigated the efficacy of chlorogenic acid on altering body fat in high-fat diet (37% calories from fat) induced-obese mice compared to caffeic acid. Caffeic acid or chlorogenic acid was supplemented with high-fat diet at 0.02% (wt/wt) dose. Both caffeic acid and chlorogenic acid significantly lowered body weight, visceral fat mass and plasma leptin and insulin levels compared to the high-fat control group. They also lowered triglyceride (in plasma, liver and heart) and cholesterol (in plasma, adipose tissue and heart) concentrations. Triglyceride content in adipose tissue was significantly lowered, whereas the plasma adiponectin level was elevated by chlorogenic acid supplementation compared to the high-fat control group. Body weight was significantly correlated with plasma leptin (r=0.894, p<0.01) and insulin (r=0.496, p<0.01) levels, respectively. Caffeic acid and chlorogenic acid significantly inhibited fatty acid synthase, 3-hydroxy-3-methylglutaryl CoA reductase and acyl-CoA:cholesterol acyltransferase activities, while they increased fatty acid beta-oxidation activity and peroxisome proliferator-activated receptors alpha expression in the liver compared to the high-fat group. These results suggest that caffeic acid and chlorogenic acid improve body weight, lipid metabolism and obesity-related hormones levels in high-fat fed mice. Chlorogenic acid seemed to be more potent for body weight reduction and regulation of lipid metabolism than caffeic acid.
Cho
Ae-Sim
AS
Department of Nutrition Education, Graduate School of Education, Sunchon National University, Suncheon 540-742, Republic of Korea.
Jeon
Seon-Min
SM
Kim
Myung-Joo
MJ
Yeo
Jiyoung
J
Seo
Kwon-Il
KI
Choi
Myung-Sook
MS
Lee
Mi-Kyung
MK
D052242:Adiponectin / Q000097:blood; D050154:Adiposity / Q000187:drug effects; D000818:Animals; D019440:Anti-Obesity Agents; D000975:Antioxidants / Q000494:pharmacology; D015153:Blotting, Western; D001835:Body Weight / Q000187:drug effects; D002109:Caffeic Acids / Q000494:pharmacology; D002726:Chlorogenic Acid / Q000494:pharmacology*; D004041:Dietary Fats / Q000009:adverse effects*; D004435:Eating / Q000502:physiology; D002149:Energy Intake / Q000502:physiology; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009206:Myocardium / Q000378:metabolism; D009765:Obesity / Q000188:drug therapy* / Q000209:etiology; D047493:PPAR alpha / Q000378:metabolism
D052242:Adiponectin; D019440:Anti-Obesity Agents; D000975:Antioxidants; D002109:Caffeic Acids; D004041:Dietary Fats; D007328:Insulin; D020738:Leptin; D047493:PPAR alpha; D002726:Chlorogenic Acid; C040048:caffeic acid