title: Alteration of skin laser-Doppler flux response to local cooling in gestational hypertension.
abstract: OBJECTIVE
  The pathophysiology of the pregnancy-induced hypertension is still poorly understood, especially with regard to the central autonomic nervous system control and peripheral vascular factors.
  
  
  METHODS
  Our study therefore aimed to investigate simultaneously the responses of blood pressure, heart rate, heart rate variability (HRV), and laser-Doppler (LD) flux to local cooling in healthy non-pregnant women (N = 12), in pregnant women with normal pregnancy (N = 16) and in women with gestational hypertension (N = 10).
  
  
  RESULTS
  The direct and indirect LD flux responses to local cold exposure were diminished in normotensive pregnant females (Dunnett's test, p < 0.05) when compared to non-pregnant females with normal menstrual cycle, but not in females with pregnancy-induced hypertension. In addition, blood pressure increased and heart rate decreased during cold exposure only in normotensive pregnant females, but not in pregnant hypertensive females (paired t test, p < 0.05). Simultaneously calculated heart rate variability total power of HRV and LF power values typically increased during local cold provocation test in non-pregnant females and in normotensive pregnant females (paired t test, p < 0.05). In hypertensive pregnant females HRV indices remained unchanged.
  
  
  CONCLUSIONS
  Our results indicate that the cardiovascular reactivity adaptation seen in normal pregnancy is absent in gestational hypertension.
authors.affiliation: Institute of Physiology, Medical Faculty, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia. ksenija.cankar@mf.uni-lj.si
authors.forename: Ksenija
authors.initials: K
authors.lastname: Cankar
authors.forename: Nejka
authors.initials: N
authors.lastname: Potocnik
authors.forename: Martin
authors.initials: M
authors.lastname: Strucl
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D017704:Baroreflex / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D004562:Electrocardiography; D005260:Female; D005498:Follicular Phase / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000175:diagnosis* / Q000503:physiopathology; D017078:Laser-Doppler Flowmetry; D008183:Luteal Phase / Q000502:physiology; D011247:Pregnancy; D012039:Regional Blood Flow / Q000502:physiology; D012867:Skin / Q000503:physiopathology*