title: Engineering static and dynamic control of synthetic pathways.
abstract: Maximizing the production of a desired small molecule is one of the primary goals in metabolic engineering. Recent advances in the nascent field of synthetic biology have increased the predictability of small-molecule production in engineered cells growing under constant conditions. The next frontier is to create synthetic pathways that adapt to changing environments.
authors.affiliation: Department of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA 94720, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Holtz
authors.forename: Jay D
authors.initials: JD
authors.lastname: Keasling
mesh_terms: D057005:Bioengineering; D004926:Escherichia coli / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D053858:Metabolic Networks and Pathways; D009876:Operon