A structural guide to proteins of the NF-kappaB signaling module.
The prosurvival transcription factor NF-kappaB specifically binds promoter DNA to activate target gene expression. NF-kappaB is regulated through interactions with IkappaB inhibitor proteins. Active proteolysis of these IkappaB proteins is, in turn, under the control of the IkappaB kinase complex (IKK). Together, these three molecules form the NF-kappaB signaling module. Studies aimed at characterizing the molecular mechanisms of NF-kappaB, IkappaB, and IKK in terms of their three-dimensional structures have lead to a greater understanding of this vital transcription factor system.
Huxford
Tom
T
Department of Chemistry and Biochemistry, San Diego State University, 5500 Campanile Drive, San Diego, California 92182-1030, USA.
Ghosh
Gourisankar
G
D000818:Animals; D004247:DNA / Q000737:chemistry; D019281:Dimerization; D006801:Humans; D020672:I-kappa B Proteins / Q000378:metabolism*; D008954:Models, Biological; D008968:Molecular Conformation; D016328:NF-kappa B / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000737:chemistry; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D051996:Transcription Factor RelA / Q000737:chemistry
D020672:I-kappa B Proteins; D016328:NF-kappa B; C498143:RELA protein, human; D051996:Transcription Factor RelA; D004247:DNA; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease