Intraperitoneal meshes in the repair of abdominal wall defects: comparison of polyester with collagen versus polypropylene with polyglycolic acid.
OBJECTIVE
To compare the clinical and histological outcomes of the repair of induced abdominal wall defects with Parietex and Optilene Mesh Elastic + Safil in direct contact with abdominal viscera (intraperitoneal position, IPOM).


METHODS
Sixteen rabbits were allocated into two groups with 8 animals each, corresponding to evaluation on the 30th and 60th postoperative days. All animals were submitted to two standardized symmetric abdominal wall defects, comprising all muscular layers and the peritoneum, followed by repair through the intraperitoneal placement of two different meshes. The experimental design allowed each animal to be its own control. Macroscopic aspects evaluated were: surgical site infection, mesh erosion, suture insufficiency, fistulae, intra-abdominal infection and adhesion formation. Microscopic parameters analyzed consisted of collagen deposition and the immunohistochemical healing process.


RESULTS
The formation of intraperitoneal adhesions and the other macroscopic outcome measures evaluated did not present significant statistical differences between the two meshes, neither did type I and III collagen deposition and MMP-1 and MMP-8 antibody expression. MMP-13 antibody exhibited significantly higher expression on the 30th postoperative day with Optilene+Safil and on the 60th day with Parietex.


CONCLUSIONS
Due to the similar results obtained, both macroscopically and microscopically, the meshes can be considered equivalent with respect to the healing of surgical wounds in abdominal wall defects in rabbits.
de Araújo
Ubirajara Rutilio Mendes E Ferreira
UR
Evangelical Medical School, Curitiba, Paraná, Brazil. ipem@evangelico.org.br
Czeczko
Nicolau Gregori
NG
Ribas-Filho
Jurandir Marcondes
JM
Malafaia
Osvaldo
O
Budel
Vinícius Milani
VM
Balderrama
Cynthia Maria S Rojas
CM
Zimmermann
Elise
E
Dietz
Ulrich Andreas
UA
D034861:Abdominal Wall / Q000601:surgery*; D000818:Animals; D003094:Collagen; D008297:Male; D010537:Peritoneum / Q000601:surgery*; D011091:Polyesters; D011100:Polyglycolic Acid; D011126:Polypropylenes; D011817:Rabbits; D013526:Surgical Mesh; D014945:Wound Healing
D011091:Polyesters; D011126:Polypropylenes; D011100:Polyglycolic Acid; D003094:Collagen