title: Can't hear, can't see, and too sore to play.
abstract: A 52-year-old man developed transient, migratory polyarthralgias in the presence of hearing loss. He then developed persistent leukocytosis and thrombocytosis. His initial transient, bilateral visual obscurations happened in context with bilateral disk edema and an enlarged blind spot. Visual symptoms progressed to vision loss and multiple branch retinal artery occlusions. It was not until later in the disease progression that gastrointestinal symptoms occurred. Electron microscopy of duodenal biopsies confirmed a diagnosis of Whipple disease.
authors.affiliation: Department of Ophthalmology, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Scheurer
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Kosmorsky
authors.forename: Gary S
authors.initials: GS
authors.lastname: Hoffman
authors.forename: Carol
authors.initials: C
authors.lastname: Farver
authors.forename: Michael S
authors.initials: MS
authors.lastname: Lee
authors.forename: Dean M
authors.initials: DM
authors.lastname: Cestari
mesh_terms: D018771:Arthralgia / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D015818:Eye Infections, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D034381:Hearing Loss / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D007964:Leukocytosis; D008264:Macrophages / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D015356:Retinal Artery Occlusion / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D054851:Tropheryma / Q000302:isolation & purification; D008061:Whipple Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology
chemical_list: D015662:Trimethoprim, Sulfamethoxazole Drug Combination