title: Evaluation of inherent toxicology and biocompatibility of magnesium phosphate bone cement.
abstract: Magnesium phosphate cement (MPC) is a kind of novel biodegradable bone adhesive for its distinct performance. However, there is few research work concerning on the systemic biocompatibility and genetic toxicological evaluation of MPC. In this study, the investigation on the inherited toxicology of MPC including gene mutation assay (Ames test), chromosome aberration assay (micronucleus test), and DNA damage assay (unscheduled DNA synthesis test) were carried out. Fracture healing and degradation behavior were explored for the evaluation of the biocompatibility of MPC, using macroscopical histological, histomorphometrical, and scanning electron microscopical methods. The results of mutagenicity and potential carcinogenicity of MPC extracts were negative, and the animal implantation illustrated no toxicity and good resorption. The study suggested that bioresorbable MPC was safe for application and might have potential applications for physiological fracture fixation.
authors.affiliation: Department of Orthopaedics, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Yonglin
authors.initials: Y
authors.lastname: Yu
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Changsheng
authors.initials: C
authors.lastname: Liu
authors.forename: Bingwen
authors.initials: B
authors.lastname: Zhang
authors.forename: Honghong
authors.initials: H
authors.lastname: Chen
authors.forename: Han
authors.initials: H
authors.lastname: Guo
authors.forename: Gaoren
authors.initials: G
authors.lastname: Zhong
authors.forename: Weidong
authors.initials: W
authors.lastname: Qu
authors.forename: Songhui
authors.initials: S
authors.lastname: Jiang
authors.forename: Huangyuan
authors.initials: H
authors.lastname: Huang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001843:Bone Cements / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D017616:Magnesium Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010710:Phosphates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011817:Rabbits; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D017616:Magnesium Compounds; D010710:Phosphates; C030781:magnesium phosphate