Interfering with perirhinal brain-derived neurotrophic factor expression impairs recognition memory in rats.
The role of brain-derived neurotrophic factor (BDNF) in recognition memory was investigated by locally infusing oligodeoxynucleotides (ODNs) into perirhinal cortex, a region of the temporal lobe essential for familiarity discrimination. Antisense but not sense BDNF ODN impaired consolidation of long-term (24 h) but not shorter-term (20 min) recognition memory.
Seoane
Ana
A
Department of Anatomy, Medical Research Council, Centre for Synaptic Plasticity, University of Bristol, Bristol, UK.
Tinsley
Chris J
CJ
Brown
Malcolm W
MW
D000818:Animals; D001483:Base Sequence; D019208:Brain-Derived Neurotrophic Factor / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000502:physiology*; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D057567:Memory, Long-Term / Q000187:drug effects / Q000502:physiology; D020319:Oligodeoxyribonucleotides, Antisense / Q000008:administration & dosage / Q000235:genetics; D051381:Rats; D021641:Recognition, Psychology / Q000187:drug effects / Q000502:physiology; D013702:Temporal Lobe / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*
D019208:Brain-Derived Neurotrophic Factor; D020319:Oligodeoxyribonucleotides, Antisense