Control of NF-kappaB activation by the COP9 signalosome.
The transcription factor NF-kappaB (nuclear factor kappaB) exerts crucial functions in the regulation of innate and adaptive immune responses, wound healing and tissue maintenance and in the development of immune cells. Tight control of NF-kappaB is essential for an efficient defence against pathogens and environmental stress to protect organisms from inflammatory diseases including cancer. An involvement of the CSN (COP9 signalosome) in the regulation of NF-kappaB has been discovered recently. The CSN is a conserved multiprotein complex, which mainly functions in the control of proteolysis. Here, we review recent observations indicating important roles of the CSN in the control of NF-kappaB in innate immunity, as well as T-cell activation and maturation.
Schweitzer
Katrin
K
Institute of Experimental Internal Medicine, Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Naumann
Michael
M
D000818:Animals; D000075686:COP9 Signalosome Complex; D007113:Immunity, Innate / Q000502:physiology*; D008213:Lymphocyte Activation / Q000276:immunology; D046912:Multiprotein Complexes / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D046912:Multiprotein Complexes; D016328:NF-kappa B; D011948:Receptors, Antigen, T-Cell; D047888:Receptors, Tumor Necrosis Factor, Type I; D010447:Peptide Hydrolases; D000075686:COP9 Signalosome Complex