title: Findings of clinical trials that evaluate the impact of medical therapies on progression of atherosclerosis.
abstract: BACKGROUND
  Arterial wall imaging has been increasingly employed in clinical trials to evaluate the impact of medical therapies on progression of atherosclerosis.
  
  
  METHODS
  A selective overview of major findings from clinical trials that assessed the impact of medical therapies on atherosclerosis progression.
  
  
  RESULTS
  Targeting established risk factors including LDL cholesterol, HDL cholesterol and blood pressure has a beneficial impact on disease progression.
  
  
  CONCLUSIONS
  As a result, vascular imaging has been employed in the early evaluation of experimental therapies.
authors.affiliation: Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Lavoie
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Uno
authors.forename: Ozgur
authors.initials: O
authors.lastname: Bayturan
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Nicholls
mesh_terms: D000792:Angiography / Q000379:methods; D050197:Atherosclerosis / Q000097:blood / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy*; D001794:Blood Pressure; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL