[Inflammatory myofibroblastic tumor].
Inflammatory myofibroblastic tumor (IMT) is a soft tissue lesion which can be found in almost all parts of the human body, but shows the highest incidence in the abdomen. It is a spindle cell lesion with prominent inflammatory infiltrate which consists predominantly of plasma cells. Using immunohistochemistry a myofibroblastic differentiation can be demonstrated. ALK is expressed in approximately 50% of tumors. The tumors are associated with a benign behavior but recurrences occur in about one third of abdominal cases. Malignant cases are rare.
Leuschner
I
I
Kindertumorregister der Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH), Sektion Kinderpathologie, Institut für Pathologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Michaelisstr. 11, 24105 Kiel.
D000008:Abdominal Neoplasms / Q000235:genetics / Q000473:pathology; D000077548:Anaplastic Lymphoma Kinase; D014408:Biomarkers, Tumor / Q000235:genetics; D002648:Child; D003937:Diagnosis, Differential; D006104:Granuloma, Plasma Cell / Q000235:genetics / Q000473:pathology*; D006801:Humans; D009379:Neoplasms, Muscle Tissue / Q000235:genetics / Q000473:pathology*; D011379:Prognosis; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000473:pathology*
D014408:Biomarkers, Tumor; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases