Dipolar molecules as impellers achieving electric-field-stimulated release.
Here we report the design of a new external electric field-controlled release system using functional dipolar molecules as nanoimpellers. The dipolar molecule 4-(3-cyanophenyl)butylene, which can reorient in response to external electric fields with different frequencies because of its strong inherent dipole moment, was synthesized and grafted onto the inner surfaces of mesopores. Under an alternating electric field, the swinging flexible molecular chains consequently push guest molecules out of the pore voids. This innovative approach to controlled release may provide important application opportunities in tumor treatment with a number of advantages in terms of local release with targetability, external remote control, and the nonelectrochemical nature of the process.
Zhu
Yingchun
Y
Key Lab of Inorganic Coating Materials, Shanghai Institute of Ceramics, CASS, Shanghai 200050, China. yzhu@mail.sic.ac.cn
Liu
Huijuan
H
Li
Fang
F
Ruan
Qichao
Q
Wang
Hua
H
Fujiwara
Masahiro
M
Wang
Lianzhou
L
Lu
G Q Max
GQ
D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D002073:Butanes / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D004574:Electromagnetic Fields; D007052:Ibuprofen / Q000008:administration & dosage*; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
C547328:4-(3-cyanophenyl)butylene; D018712:Analgesics, Non-Narcotic; D002073:Butanes; D009570:Nitriles; D012822:Silicon Dioxide; D007052:Ibuprofen