Schistosome genomes: a wealth of information.
The blood flukes Schistosoma japonicum and Schistosoma mansoni are the first major human platyhelminth pathogens to have their genome sequences published. The work of two large international consortia offers draft sequence information and detailed analyses presenting a wealth of information addressing, in particular, metabolic and signalling pathways, host-parasite interactions and potential new drug targets. We comment on these breakthroughs and their potential applications in the study and control of schistosomes.
Webster
Joanne P
JP
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, UK. joanne.webster@imperial.ac.uk
Oliviera
Guilherme
G
Rollinson
David
D
Gower
Charlotte M
CM
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D015195:Drug Design; D049751:Genome, Helminth / Q000235:genetics*; D006801:Humans; D011634:Public Health; D012547:Schistosoma / Q000235:genetics*; D012552:Schistosomiasis / Q000188:drug therapy
D000871:Anthelmintics