Catalytic asymmetric total synthesis of tangutorine.
The first enantioselective total synthesis of tangutorine has been achieved, wherein a Pd-catalyzed asymmetric allylic amination using a chiral diaminophosphine oxide (DIAPHOX) preligand was the key step.
Nemoto
Tetsuhiro
T
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
Yamamoto
Eri
E
Franzén
Robert
R
Fukuyama
Takashi
T
Wu
Riliga
R
Fukamachi
Toshihiko
T
Kobayashi
Hiroshi
H
Hamada
Yasumasa
Y
D000498:Allyl Compounds / Q000737:chemistry; D000586:Amination; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004365:Drugs, Chinese Herbal / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D011807:Quinolizines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000498:Allyl Compounds; D002243:Carbolines; D004365:Drugs, Chinese Herbal; D011807:Quinolizines; C485396:tangutorine; D010165:Palladium