The mighty mice prove pluripotency for iPSCs.
By injecting induced pluripotent stem cells (iPSCs) into tetraploid blastocysts to generate live pups, two groups in China demonstrated that the injected cells are as pluripotent as embryonic stem cells, i.e. capable of giving rise to every cell in the newborn mice. This achievement validates iPS technology for regenerative medicine.
Pei
Duanqing
D
Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510663, China. pei_duanqing@gibh.ac.cn
D000818:Animals; D001755:Blastocyst / Q000166:cytology; D054337:Cell Dedifferentiation; D019070:Cell Lineage; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D051379:Mice; D008845:Microinjections; D011123:Polyploidy