title: [Noninvasive prenatal test in the first trimester of pregnancy (NT and estimation of beta-hCG and PAPP-A) in the diagnosis of fetal abnormalities in Polish population--comparison of the biochemistry own normal ranges and literature reported data].
abstract: OBJECTIVE
  Estimation of Polish population standards of the concentrations of pregnancy-associated plasma protein--A (PAPP-A) and free beta--human chorionic gonadotropin (beta-HCG) in the maternal blood between 10.0 and 13.6 week of pregnancy and comparison of the biochemistry own normal ranges and literature reported data. Estimation the sensitivity of the fetal nuchal translucency measurement, biochemical concentrations of PAPP-A and free beta-HCG in detection of the fetal chromosomal abnormalities.
  
  
  METHODS
  582 women in the age 14 to 46 years old with singleton pregnancies were included to the study The screening was performed between 10.0 and 13.6 week of gestation. The fetal nuchal translucency serum concentrations of PAPP-A and free beta-HCG were measured. The specific risk was calculated using the Fetal Medicine Foundation software (FTS) by accredited sonographers.
  
  
  RESULTS
  Standards for serum concentrations of PAPP-A and free beta-HCG in normal pregnancies were determined. The measurement sensitivity of the fetal nuchal translucency in detection of the fetal chromosomal abnormalities was 80% and sensitivity of serum concentrations of PAPP-A and free beta-HCG was 40% and 80%.
  
  
  CONCLUSIONS
  There is no significant differences between estimated biochemistry standards (PAPP-A and free beta-HCG) for Polish population and literature reported data. Observed differences in measurements of fetal NT, serum concentrations of PAPP-A and free beta-HCG in a control group and the group with the aneuploidies confirmed usefulness of these methods for the first trimester prenatal screening.
authors.affiliation: Klinika Medycyny Ptodu i Ginekologii I Katedry Ginekologii i Połoznictwa Uniwersytetu Medycznego w Łodzi. getman@op.pl
authors.forename: Sofija
authors.initials: S
authors.lastname: Mandryka-Stankewycz
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Perenc
authors.forename: Grazyna
authors.initials: G
authors.lastname: Dec
authors.forename: Piotr
authors.initials: P
authors.lastname: Sieroszewski
mesh_terms: D000293:Adolescent; D000328:Adult; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D004314:Down Syndrome / Q000175:diagnosis*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D048208:Nuchal Translucency Measurement; D011044:Poland / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D011261:Pregnancy Trimester, First; D018566:Pregnancy, High-Risk; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D012016:Reference Values; D055815:Young Adult
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D011266:Pregnancy-Associated Plasma Protein-A