Vesicular phospholipid gels.
Highly concentrated phospholipid dispersions of vesicular morphology, Vesicular phospholipid Gels (VPGs) are of importance for sustained release of drugs upon implantation, or, upon transfer into SUV-dispersions, for drug delivery upon i.v. injection. Here the formation of homogeneous lipid and lipid/drug-blends is described as well as the preparation of VPGs by high-pressure homogenization, along with remote loading via "passive loading".
Brandl
Martin
M
Department of Physics and Chemistry, University of Southern Denmark, Odense M, Denmark.
D054697:Cytostatic Agents / Q000008:administration & dosage; D003692:Delayed-Action Preparations / Q000737:chemistry*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005612:Freeze Drying; D005782:Gels / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry*; D011312:Pressure; D000093542:Gemcitabine
D054697:Cytostatic Agents; D003692:Delayed-Action Preparations; D005782:Gels; D010743:Phospholipids; D003841:Deoxycytidine; D000093542:Gemcitabine