title: Evaluation of the accumulation of (11)C-methionine with standardized uptake value in the normal brain.
abstract: The aim of this study was to determine the normal l-[methyl-(11)C]-methionine ((11)C-methionine) uptake and the extent of variation using standardized uptake value (SUV).
  
  
  METHODS
  Five healthy volunteers and 58 adult patients with normal (11)C-methionine uptake were included in the interindividual analysis and 22 patients in the intraindividual analysis. SUVs in different brain regions, age-associated changes, correlation between 2 correction methods (for body weight [w-SUV] or body surface area [s-SUV]), and intraindividual reproducibility were examined.
  
  
  RESULTS
  w-SUVs were statistically different between the brain regions. The frontal or parietal cortex showed lower coefficients of variation than did the cerebellum or brain stem. There was no significant age-associated change. w-SUVs showed lower coefficients of variation in interindividual analysis and lower symmetric percentage change in intraindividual reproducibility than did s-SUVs.
  
  
  CONCLUSIONS
  SUVs in the normal brain show inter- and intraindividual variation, and our proposed normal w-SUVs represent an important reference value.
authors.affiliation: Department of Neurosurgery, Graduate School of Medicine, Osaka City University, Abeno-ku, Osaka, Japan. uda@med.osaka-cu.ac.jp
authors.forename: Takehiro
authors.initials: T
authors.lastname: Uda
authors.forename: Naohiro
authors.initials: N
authors.lastname: Tsuyuguchi
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Terakawa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Takami
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohata
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001693:Biological Transport, Active; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000706:statistics & numerical data; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012016:Reference Values; D015203:Reproducibility of Results; D014018:Tissue Distribution; D055815:Young Adult
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D008715:Methionine; C038344:methionine methyl ester