title: Phenolic glycosides from Dodecadenia grandiflora and their glucose-6-phosphatase inhibitory activity.
abstract: Phytochemical investigation of Dodecadenia grandiflora leaves led to the isolation and identification of three phenolic glycosides, designated 1-[(4'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol (1), 1-[(6'-O-(E)-p-coumaroyl)-beta-D-glucopyranosyl]-oxy-2-phenol (2) and 1-[O-beta-D-glucopyranosyl(1-->2)-beta-D-glucopyranosyl]-oxy-2-phenol (3), along with nine known compounds. Compounds 1, 2, 5 and 9 exhibited significant glucose-6-phosphatase inhibitory activity (63.7, 66.9, 82.9 and 85.4%) with IC(50) values of 88.5, 81.0, 51 and 50 microM respectively. On the basis of biological results, a structure-activity relationship has been discussed.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226 001, India.
authors.forename: Manmeet
authors.initials: M
authors.lastname: Kumar
authors.forename: Preeti
authors.initials: P
authors.lastname: Rawat
authors.forename: Mohammad Faheem
authors.initials: MF
authors.lastname: Khan
authors.forename: Akhilesh K
authors.initials: AK
authors.lastname: Tamarkar
authors.forename: Arvind K
authors.initials: AK
authors.lastname: Srivastava
authors.forename: Kamal R
authors.initials: KR
authors.lastname: Arya
authors.forename: Rakesh
authors.initials: R
authors.lastname: Maurya
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D005952:Glucose-6-Phosphatase / Q000037:antagonists & inhibitors*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D020128:Inhibitory Concentration 50; D019770:Lauraceae / Q000737:chemistry*; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D006027:Glycosides; D010636:Phenols; D005952:Glucose-6-Phosphatase