title: Continuous coronary sinus perfusion reverses ongoing myocardial damage in acute ischemia.
abstract: Acute cardiogenic shock or cardiac arrest (CS/CA) before cardiopulmonary bypass (CPB) installation are life-threatening events in acute coronary syndromes. We evaluated whether continuous retrograde warm-blood perfusion(CRWBP) before aortic cross-clamping (ACC),with immediate CPB installation may improve hospital results in these dreadful events. Hospital outcome of 18 coronary artery bypass grafting (CABG) (Group A) with CS/CA before CPB, with immediate CPB installation and CRWBP,has been compared with 24 CABG (Group B) with CS/CA undergoing only immediate CPB installation. No differences have been detected in the mean time to establish CPB(P = 0.655). Electrocardiography normalized in a significantly higher number of CRWBP (P = 0.0001). Group B showed longer CPB (116.2 +/- 21.2 min vs. 157.8 +/- 32.4;P = 0.0001) and postoperative intra-aortic balloon pumping time course (36.2 +/- 5.9 h vs. 77.8 +/-13.2; P = 0.0001).CRWBP reduced postoperative acute myocardial infarction (P = 0.004) and damage (P = 0.033), death (P = 0.026),and need for high inotropic support (0% vs. 37.5%; P =0.003). Troponin I was significantly lower in Group A(P = 0.013 from coronary sinus; P </= 0.0001 at 12, 24, and 48 h postoperatively; P = 0.008 at 72 h), never reaching values suggestive of acute myocardial infarction. Group A had also lower lactate release from aortic declamping to 48 h postoperatively (P </= 0.0001).CRWBP improved post operative left ventricular ejection fraction (EF) (P = 0.017)and wall motion score index (P = 0.041), whereas Group B showed a significant worsening of EF (P = 0.0001) and wall motion score index (P = 0.002). Patients in Group A had shorter intubation time (P = 0.0001), intensive therapy unit(ITU) stay (P = 0.001), and hospital stay (P = 0.0001).CRWBP reverses myocardial damage in patients with CS/CA during acute coronary syndromes, adding a straightforward benefit to hospital survival.
authors.affiliation: Cardiac Surgery Unit, Magna Graecia University, Catanzaro, Italy. frankono@libero.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Onorati
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Santarpino
authors.forename: Lucia
authors.initials: L
authors.lastname: Cristodoro
authors.forename: Cristian
authors.initials: C
authors.lastname: Scalas
authors.forename: Francesco Saverio
authors.initials: FS
authors.lastname: Costanzo
authors.forename: Attilio
authors.initials: A
authors.lastname: Renzulli
mesh_terms: D054058:Acute Coronary Syndrome / Q000628:therapy; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002315:Cardiopulmonary Bypass; D002316:Cardiotonic Agents / Q000008:administration & dosage; D001026:Coronary Artery Bypass; D003331:Coronary Vessels; D003404:Creatinine / Q000097:blood; D016757:Death, Sudden, Cardiac / Q000517:prevention & control; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000503:physiopathology; D006323:Heart Arrest / Q000628:therapy; D006439:Hemodynamics; D006801:Humans; D007362:Intensive Care Units; D007423:Intra-Aortic Balloon Pumping; D019344:Lactic Acid / Q000097:blood; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy*; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000473:pathology*; D012107:Research Design; D012189:Retrospective Studies; D012770:Shock, Cardiogenic / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome; D019210:Troponin I / Q000097:blood
chemical_list: D015415:Biomarkers; D002316:Cardiotonic Agents; D019210:Troponin I; D019344:Lactic Acid; D003404:Creatinine