Plasma concentrations of apolipoproteins A-I, B, and M in patients with critical limb ischemia.
OBJECTIVE
Apolipoproteins affect development of atherosclerosis, but their involvement in the pathogenesis of critical limb ischemia (CLI), a severe form of atherosclerosis, has not previously been examined.


METHODS
ApoA-I, apoB, and apoM were measured in plasma from 196 CLI subjects and 214 control individuals from the background population.


RESULTS
Cases had lower levels of the apolipoproteins, as compared to controls; apoA-I, 1.23 vs. 2.08 g/L; apoB, 0.93 vs. 1.04 g/L; apoM, 0.75 vs. 0.91 mumol/L (p<0.0001 for all three). ApoA-I and apoM correlated negatively with inflammatory markers and positively to 1- and 3-year survival rates, whereas apoB did not. In multivariate analyses, apoA-I, but not apoB and apoM, was independently associated with CLI, the odds ratio being 0.015.


CONCLUSIONS
In subjects with CLI, plasma concentrations of apoA-I, apoB and apoM were significantly lower than in control individuals, but only apoA-I was independently associated to CLI.
Ahnström
Josefin
J
Lund University, Department of Laboratory Medicine, Division of Clinical Chemistry, Wallenberg laboratory, entrance 46, floor 6, University Hospital, Malmö, S-20502 Malmö, Sweden.
Gottsäter
Anders
A
Lindblad
Bengt
B
Dahlbäck
Björn
B
D000368:Aged; D000369:Aged, 80 and over; D016632:Apolipoprotein A-I / Q000032:analysis / Q000097:blood*; D001053:Apolipoproteins / Q000032:analysis / Q000097:blood*; D001055:Apolipoproteins B / Q000032:analysis / Q000097:blood*; D000075243:Apolipoproteins M; D016022:Case-Control Studies; D016638:Critical Illness / Q000401:mortality; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood* / Q000401:mortality; D054834:Lipocalins; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D009994:Osmolar Concentration; D016491:Peripheral Vascular Diseases / Q000097:blood / Q000401:mortality; D016019:Survival Analysis
C400523:APOM protein, human; D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D001055:Apolipoproteins B; D000075243:Apolipoproteins M; D054834:Lipocalins