Vinyl sulfone: a versatile function for simple bioconjugation and immobilization.
The easy functionalization of tags and solid supports with the vinyl sulfone function is a valuable tool in omic sciences that allows their coupling with the amine and thiol groups present in the proteogenic residues of proteins, in mild and green conditions compatible with their biological function.
Morales-Sanfrutos
Julia
J
Departamento de Q. Orgánica, Facultad de Ciencia, Instituto de Biotecnologia, Universidad de Granada, Granada, 18071 SPAIN.
Lopez-Jaramillo
Javier
J
Ortega-Muñoz
Mariano
M
Megia-Fernandez
Alicia
A
Perez-Balderas
Francisco
F
Hernandez-Mateo
Fernando
F
Santoyo-Gonzalez
Francisco
F
D000588:Amines / Q000737:chemistry; D000818:Animals; D002417:Cattle; D006863:Hydrogen-Ion Concentration; D055767:Immobilized Proteins / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D008958:Models, Molecular; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D013194:Staining and Labeling; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature
D000588:Amines; D055767:Immobilized Proteins; D007202:Indicators and Reagents; D011506:Proteins; D012235:Rhodamines; D013450:Sulfones; C009873:divinyl sulfone; D012822:Silicon Dioxide; C029773:rhodamine B