title: Tight orbit syndrome: a previously unrecognized cause of open-angle glaucoma.
abstract: OBJECTIVE
  To describe a new syndrome of tight orbit and intractable glaucoma with a poor visual prognosis.
  
  
  METHODS
  A retrospective observational case series of six patients seen at two centres between 2001 and 2007 assessing intraocular pressure (IOP), best-corrected visual acuity and visual field.
  
  
  RESULTS
  Three men and three women, ranging in age at diagnosis from 14 to 53 years, demonstrated similar orbital features and progressive visual field loss despite intensive management with medication and laser and operative surgery. Highest IOPs ranged from 30 to 50 mmHg. Trabeculectomy and/or glaucoma drainage devices were attempted in five patients but all failed. One patient underwent orbital decompression with achievement of IOP control. Final IOP at last follow-up was variable; only two patients achieved IOP in the normal range, with the rest ranging from 25 to 40 mmHg. All patients had advanced visual field loss.
  
  
  CONCLUSIONS
  Tight orbit syndrome presents a serious clinical challenge. Despite maximum medical therapy and surgical intervention IOP is difficult to control, resulting in progressive visual field loss.
authors.affiliation: City Eye Centre, Brisbane, Queensland, Australia. eye@cityeye.com.au
authors.forename: Graham A
authors.initials: GA
authors.lastname: Lee
authors.forename: Robert
authors.initials: R
authors.lastname: Ritch
authors.forename: Steve Y-W
authors.initials: SY
authors.lastname: Liang
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Liebmann
authors.forename: Philip
authors.initials: P
authors.lastname: Dubois
authors.forename: Matthew
authors.initials: M
authors.lastname: Bastian-Jordan
authors.forename: Kate
authors.initials: K
authors.lastname: Lehmann
authors.forename: Prin
authors.initials: P
authors.lastname: Rojanapongpun
mesh_terms: D000293:Adolescent; D000328:Adult; D019299:Decompression, Surgical; D005260:Female; D005500:Follow-Up Studies; D020327:Glaucoma Drainage Implants; D005902:Glaucoma, Open-Angle / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009916:Orbital Diseases / Q000150:complications* / Q000601:surgery; D012189:Retrospective Studies; D013577:Syndrome; D014130:Trabeculectomy; D017211:Treatment Failure; D014786:Vision Disorders / Q000209:etiology; D014794:Visual Fields; D055815:Young Adult