Facile preparation of 3-substituted benzisothiazoles from o-mercaptoacylphenones.
A synthesis of 3-substituted benzisothiazoles starting from readily available o-mercaptoacylphenones is presented. The key cyclization step features a mild S-nitrosation and its succeeding intramolecular aza-Wittig reaction leading to the construction of the title compounds.
Devarie-Baez
Nelmi O
NO
Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
Xian
Ming
M
D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry
D001555:Benzene Derivatives; D013438:Sulfhydryl Compounds; D013844:Thiazoles; C466948:benzisothiazole