Microalbuminuria in cerebrovascular disease: a modifiable risk factor?
Stroke is potentially preventable through risk factor modification. Over the past decade, there has been considerable interest on microalbuminuria as a risk factor for chronic diseases. The concept of microalbuminuria was originally introduced, about 25 years ago, to clinical practice as a useful marker of nephropathy. Since then various studies reported an association of microalbuminuria with the increased risk of cardiovascular events and all cause of mortality in subjects with or without diabetes. The presence of microalbuminuria was related to left ventricular dysfunction, stroke, and myocardial infarction. Microalbuminuria may be a predictor of stroke but further studies are required. However data on prognostic significance and therapeutic consequence, particularly in haemorrhagic stroke are lacking. This review focuses on the importance of microalbuminuria for cerebrovascular disease, stressing the clinical and therapeutic implications using antihypertensive therapy to control the urinary albumin excretion.
Rocco
A
A
Department of Neurology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany. andrea.rocco@med.uni-heidelberg.de
Heerlein
K
K
Diedler
J
J
Sykora
M
M
Barrows
R
R
Hacke
W
W
Steiner
Th
T
D000419:Albuminuria / Q000209:etiology*; D002561:Cerebrovascular Disorders / Q000150:complications*; D048909:Diabetes Complications / Q000378:metabolism; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000150:complications; D018696:Neuroprotective Agents / Q000627:therapeutic use; D011379:Prognosis; D012107:Research Design; D012307:Risk Factors; D018805:Sepsis / Q000150:complications
D018696:Neuroprotective Agents