title: Epilepsy research 150 years after Darwin's theory of evolution.
abstract: On February 12, 2009, we commemorated the 200th anniversary of Charles Darwin's birth and the 150th anniversary of the publication of the first edition of the 'On the origin of species'. Only in the sixth edition of the Origin Darwin explicitly stated that natural selection applied to the brain as to all other organs and contemporary epilepsy research plays an interesting role in this scenario. Epilepsy affects approximately 3 percent of the general population and is a complex disease. At least 11 genes have now been described for human epilepsy and over 50 more genes have been identified in animal models of epilepsy. The complex gene to gene interactions and gene-environment interactions may account for epilepsy susceptibility and antiepileptic drug response. Darwin's thoughts on evolution are relevant to understand these gene interactions, contributing to current development of new treatments and prevention of chronic diseases, such as epilepsy.
authors.affiliation: Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil. scorza.nexp@epm.br
authors.forename: Fulvio A
authors.initials: FA
authors.lastname: Scorza
authors.forename: Vera C
authors.initials: VC
authors.lastname: Terra
authors.forename: Carla A
authors.initials: CA
authors.lastname: Scorza
authors.forename: Ricardo M
authors.initials: RM
authors.lastname: Arida
authors.forename: Esper A
authors.initials: EA
authors.lastname: Cavalheiro
mesh_terms: D005075:Biological Evolution; D004827:Epilepsy / Q000235:genetics*; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D012641:Selection, Genetic / Q000235:genetics*