Cyanative alkene-aldehyde coupling: Ni(0)-NHC-Et2AlCN mediated chromanol synthesis with high cis-selectivity at room temperature.
Described are several classes of Ni(0) mediated cyanative alkene-aldehyde coupling reactions, providing 6-membered cores, which complement existing cyclization technology in several respects. Et(2)AlCN was used as both a cyclization accelerator and CN source. The NHC ligand may have a positive effect in differentiating reductive elimination and syn-beta-hydride elimination.
Ho
Chun-Yu
CY
Center of Novel Functional Molecules, Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR. jasonhcy@cuhk.edu.hk