title: MicroTUB(B3)ules and brain development.
abstract: The microtubule network is crucial for the developing nervous system, and mutations in tubulin-encoding genes disrupt neuronal migration. Tischfield et al. (2010) now report that mutations in the tubulin-encoding gene TUBB3 have a striking impact on microtubule dynamics in neurons, resulting in a diverse set of disease symptoms.
authors.affiliation: Howard Hughes Medical Institute, Cambridge, MA 02139, USA.
authors.forename: Karun K
authors.initials: KK
authors.lastname: Singh
authors.forename: Li-Huei
authors.initials: LH
authors.lastname: Tsai
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology* / Q000378:metabolism; D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D009154:Mutation; D055495:Neurogenesis; D014404:Tubulin / Q000235:genetics / Q000378:metabolism*
chemical_list: C498585:TUBB3 protein, human; D014404:Tubulin