title: Usefulness of intraoperative parathyroid hormone measurements in patients with renal hyperparathyroidism.
abstract: BACKGROUND
  In renal hyperparathyroidism, it remains unclear whether intraoperative parathyroid hormone (PTH) measurements can predict postoperative outcome and guide the extent of surgical exploration.
  
  
  METHODS
  In 42 parathyroidectomies for renal hyperparathyroidism, we analyzed the predictive value of the Miami Criterion of 50% intraoperative PTH decrease. We used receiver operating characteristic (ROC) curves to find the criterion with the best diagnostic performance. We also investigated whether the whole PTH assay improved accuracy.
  
  
  RESULTS
  Twenty-six operations (62%) resulted in normal postoperative PTH. With the Miami Criterion, cure was predicted with a sensitivity of 95% and specificity of only 8%. Specificity could be improved to 50% using a 70% PTH decrease as cut-off level. The whole PTH assay did not improve accuracy.
  
  
  CONCLUSIONS
  Prediction of cure after parathyroidectomy for renal hyperparathyroidism might be improved with a criterion of 70% PTH decrease 10 minutes after excision of all parathyroid glands. Prospective analysis needs to validate this new criterion.
authors.affiliation: Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. k.freriks@endo.umcn.nl
authors.forename: Kim
authors.initials: K
authors.lastname: Freriks
authors.forename: Ad R M M
authors.initials: AR
authors.lastname: Hermus
authors.forename: Ruud G L
authors.initials: RG
authors.lastname: de Sévaux
authors.forename: Han J
authors.initials: HJ
authors.lastname: Bonenkamp
authors.forename: Jan
authors.initials: J
authors.lastname: Biert
authors.forename: Martin
authors.initials: M
authors.lastname: den Heijer
authors.forename: Fred C G J
authors.initials: FC
authors.lastname: Sweep
authors.forename: Henk W
authors.initials: HW
authors.lastname: van Hamersvelt
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology / Q000601:surgery*; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D016105:Parathyroidectomy; D011184:Postoperative Period; D011237:Predictive Value of Tests; D012372:ROC Curve; D051437:Renal Insufficiency / Q000150:complications; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D010281:Parathyroid Hormone