title: Semi-automatic assessment of global left ventricular function and left ventricular parameters with dual-source computed tomography: comparison with invasive angiography.
abstract: This study assesses the global left ventricular function and volumes using dual-source computed tomography (DSCT) with improved temporal resolution (83 ms) by use of a semi-automatic software tool in comparison to invasive angiography (IVA). One hundred patients scheduled for invasive coronary angiography because of suspected or known coronary artery disease (80 men; 20 women, mean age 62 +/- 10 years) were additionally examined by DSCT. Global left ventricular function (LVF), left ventricular end-diastolic volume (LVEDV), end-systolic volume (LVESV), and stroke volume (SV) were calculated by the use of semi-automatic post-processing software and results compared with those of IVA. Bland-Altman analysis revealed a good concordance between DSCT and IVA in terms of LVF: Pearson's r 0.78, confidence interval [CI] 0.68-0.86, P < 0.0001, bias 7.1% +/- 9.1%. The same was true for LVESV (Pearson's r 0.78, CI 0.67-0.85, P < 0.0001, bias 15.0 +/- 21.0 ml), whereas the agreement for LVEDV and SV was only moderate (LVEDV: Pearson's r 0.59, CI 0.43-0.72, P < 0.0001, bias 13.0 +/- 18.1 ml; SV: Pearson's r 0.47, CI 0.28-0.62, P < 0.0001, bias -1.4 +/- 28.4 ml). Semi-automatic evaluation of left ventricular parameters with DSCT revealed good correlation for LVF and LVESV, whereas LVEDV and SV showed only a moderate correlation. Moreover, LVF is systematically underestimated by DSCT.
authors.affiliation: Department of Cardiology, University of Tuebingen, Tuebingen, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Drosch
authors.forename: Ilias
authors.initials: I
authors.lastname: Tsiflikas
authors.forename: Harald
authors.initials: H
authors.lastname: Brodoefel
authors.forename: Martin
authors.initials: M
authors.lastname: Heuschmid
authors.forename: Anja
authors.initials: A
authors.lastname: Reimann
authors.forename: Christoph
authors.initials: C
authors.lastname: Thomas
authors.forename: Dominik
authors.initials: D
authors.lastname: Ketelsen
authors.forename: Diana
authors.initials: D
authors.lastname: Wurster
authors.forename: Stephen
authors.initials: S
authors.lastname: Schroeder
authors.forename: Christof
authors.initials: C
authors.lastname: Burgstahler
mesh_terms: D000368:Aged; D057205:Automation, Laboratory; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D013318:Stroke Volume; D014057:Tomography, X-Ray Computed; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D016277:Ventricular Function, Left