title: Left-right determination: involvement of molecular motor KIF3, cilia, and nodal flow.
abstract: Mammalian left-right determination is a good example for how multiple cell biological processes coordinate in the formation of a basic body plan. The leftward movement of fluid at the ventral node, called nodal flow, is the central process in symmetry breaking on the left-right axis. Nodal flow is autonomously generated by the rotation of posteriorly tilted cilia that are built by transport via KIF3 motor on cells of the ventral node. How nodal flow is interpreted to create left-right asymmetry has been a matter of debate. Recent evidence suggests that the leftward movement of sheathed lipidic particles, called nodal vesicular parcels (NVPs), may result in the activation of the noncanonical hedgehog signaling pathway, an asymmetric elevation in intracellular Ca(2+) and changes in gene expression.
authors.affiliation: Department of Cell Biology and Anatomy, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, Tokyo, 113-0033 Japan. hirokawa@m.u-tokyo.ac.jp
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hirokawa
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okada
mesh_terms: D000818:Animals; D001695:Biology / Q000379:methods; D019521:Body Patterning; D002923:Cilia / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000378:metabolism; D006801:Humans; D016547:Kinesins / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D015398:Signal Transduction
chemical_list: C087415:KIF3A protein, human; D016547:Kinesins