A Putative Case of Methotrexate-Related Lymphoma: Clinical Course and PET/CT Findings.
Patients with autoimmune conditions develop lymphoproliferative disorders (LPDs) at a higher frequency than normal both in association with and independent of Methotrexate (MTX). We describe a case of MTX-associated lymphoma in a patient with psoriasis on long-standing MTX. The case is notable for the initial tumor burden, the dramatic disappearance of the PET-CT findings on discontinuation of MTX, and the subsequent early regrowth of disease. Our case report is illustrative of an MTX-related NHL in an autoimmune patient. Conclusion. Withdrawal of MTX in a patient with lymphoma is reasonable before initiating chemotherapy, but observation for early regrowth of disease is necessary.
Jankowitz
Rachel C
RC
Department of Oncology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Ganon
James
J
Blodgett
Todd
T
Garcia
Christine
C
Jacobs
Samuel
S