title: Recent advances in association studies of osteoarthritis susceptibility genes.
abstract: Osteoarthritis (OA) is a polygenic disease with a definite genetic component, and recent advances in genome research have enabled us to investigate OA susceptibility genes. Several research groups, including ours, have reported the identification of OA susceptibility genes, mainly using candidate gene association studies. However, we are now entering the era of genome-wide association studies (GWAS). Here, we review recent progress in the study of susceptibility genes for OA, focusing in particular on GWAS and large-scale replication studies.
authors.affiliation: Center for Genomic Medicine, Riken, Japan.
authors.forename: Jin
authors.initials: J
authors.lastname: Dai
authors.forename: Shiro
authors.initials: S
authors.lastname: Ikegawa
mesh_terms: D024142:Collagen Type VI / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods / Q000639:trends*; D055428:Growth Differentiation Factor 5 / Q000235:genetics; D006801:Humans; D010003:Osteoarthritis / Q000235:genetics*; D011544:Pseudogenes
chemical_list: C531065:COL6A4P1 protein, human; D024142:Collagen Type VI; C525893:GDF5 protein, human; D055428:Growth Differentiation Factor 5