Peptide-based activity-based probes (ABPs) for target-specific profiling of protein tyrosine phosphatases (PTPs).
Synthesis of a novel unnatural amino acid (2-FMPT) for the solid-phase synthesis of peptide-based probes suitable for target-specific activity-based profiling of protein tyrosine phosphatases from crude proteomes is reported.
Kalesh
Karunakaran A
KA
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Tan
Lay Pheng
LP
Lu
Kai
K
Gao
Liqian
L
Wang
Jigang
J
Yao
Shao Q
SQ
D000818:Animals; D002460:Cell Line; D006801:Humans; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D019000:Phosphotyrosine / Q000031:analogs & derivatives*; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D020543:Proteome / Q000378:metabolism; D040901:Proteomics; D013379:Substrate Specificity
D010455:Peptides; D020543:Proteome; D019000:Phosphotyrosine; D017027:Protein Tyrosine Phosphatases