title: Mycobacterium tuberculosis Beijing genotype is an independent risk factor for tuberculosis treatment failure in Indonesia.
abstract: Animal studies have shown that the globally emerging Beijing genotype strains of Mycobacterium tuberculosis are more virulent than other strains. We examined whether Beijing strains increase treatment failure in a prospective cohort study in Indonesia. Among 818 tuberculosis cases, positive sputum culture results after 6 months of treatment were more common among patients infected with Beijing strains (33.4%) than among those infected with non-Beijing strains (relative risk, 1.94 [95% confidence interval, 1.26-3.00]), even after adjustment for differences in drug resistance. These data suggest that M. tuberculosis Beijing genotype strains have a higher capacity to withstand tuberculosis treatment, even in the absence of drug resistance.
authors.affiliation: Department of Clinical Pathology, Hasan Sadikin Hospital, Medical Faculty, Universitas Padjadjaran, Bandung, Indonesia.
authors.forename: Ida
authors.initials: I
authors.lastname: Parwati
authors.forename: Bachti
authors.initials: B
authors.lastname: Alisjahbana
authors.forename: Lika
authors.initials: L
authors.lastname: Apriani
authors.forename: Rista D
authors.initials: RD
authors.lastname: Soetikno
authors.forename: Tom H
authors.initials: TH
authors.lastname: Ottenhoff
authors.forename: Adri G M
authors.initials: AG
authors.lastname: van der Zanden
authors.forename: Jos
authors.initials: J
authors.lastname: van der Meer
authors.forename: Dick
authors.initials: D
authors.lastname: van Soolingen
authors.forename: Reinout
authors.initials: R
authors.lastname: van Crevel
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D005838:Genotype; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D008297:Male; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D011446:Prospective Studies; D012307:Risk Factors; D017211:Treatment Failure; D014376:Tuberculosis / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents