Oxidant/antioxidant status in premenstrual syndrome.
OBJECTIVE
To investigate oxidant/antioxidant status in premenstrual syndrome (PMS).


METHODS
Study group (n = 20) consisted of PMS and control group (n = 21) consisted of normal menstruating women. The serum oxidant status was assessed by the lipid hydroperoxide (LHP), malondialdehyde (MDA) and protein carbonyl (PC); the antioxidant status was assessed by the total thiol (T-SH) and total antioxidant capacity (TAC).


RESULTS
The study and control groups revealed no statistical difference, in terms of day 3 LHP, MDA, PC, T-SH and TAC levels. There were no significant differences between groups in terms of day 21 MDA, PC and T-SH levels. However, day 21 LHP levels were increased and TAC levels were decreased in the study group compared with the control group.


CONCLUSIONS
Increased oxidative stress and reduced antioxidant capacity may occur in PMS. It can be speculated that the imbalance of oxidant/antioxidant systems may be a cause or the consequence of the various stress symptoms in PMS.
Duvan
Candan Iltemir
CI
Department of Obstetric and Gynecology, University of Fatih, Yukari Ayranci, Ankara, Turkey. candanduvan@yahoo.com
Cumaoglu
Ahmet
A
Turhan
Nilgun Ozturk
NO
Karasu
Cimen
C
Kafali
Hasan
H
D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D016877:Oxidants / Q000097:blood*; D011293:Premenstrual Syndrome / Q000097:blood*; D050050:Protein Carbonylation; D013438:Sulfhydryl Compounds / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D055815:Young Adult
D000975:Antioxidants; D008054:Lipid Peroxides; D016877:Oxidants; D013438:Sulfhydryl Compounds; D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde