title: [Early identification and treatment of cardiovascular failure in severe sepsis].
abstract: Severe sepsis is a leading cause of death characterised by infection-induced endothelial and cardiac dysfunction leading to hypovolaemia, maldistribution of flow, tissue ischaemia and organ failure. A clinical approach with focus on cardiovascular diagnostics and rational goal-directed therapy is likely to reduce the high mortality. The treatment involves focus control, broad-spectrum antibiotics, target-oriented fluid therapy and vasopressor and inotropic agents guided by frequent reassessments of the patient's response to treatment.
authors.affiliation: Intensiv Terapiklinik 4131, Rigshospitalet, Blegdamsvej 9, DK-2100 København Ø, Denmark. nicolai.haase@regionh.com
authors.forename: Nicolai
authors.initials: N
authors.lastname: Haase
authors.forename: Jonathan
authors.initials: J
authors.lastname: White
authors.forename: Anders
authors.initials: A
authors.lastname: Perner
mesh_terms: D042241:Early Diagnosis; D004638:Emergency Treatment; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D018805:Sepsis / Q000150:complications* / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D012772:Shock, Septic / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D018746:Systemic Inflammatory Response Syndrome / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D013997:Time Factors