[Endotoxinemia and anti-endotoxin immunity in women with bacterial vaginosis].
OBJECTIVE
To assess the level of endotoxinemia and state of antiendotoxin immunity compared with parameters of humoral immunity in patients with bacterial vaginosis.


METHODS
Blood sera from 28 women with bacterial vaginosis (main group) and 24 clinically healthy women (control group). Concentration of lypopolysaccharide (LPS) in sera was measured by semi-quantitative gel-clot test using LAL-reagent Endosafe. Concentration of LBP, IgG EndoCAb as well as levels of serum IgA, IgM and IgG were measured by enzyme immunoassay.


RESULTS
Conditionally higher level of LPS, 2-fold increase of LBP concentration, 1.7-fold increase of IgG EndoCAb as well as tendency to decrease of IgA level were revealed in sera of women from the main group. Dysbiotic shift in vaginal microecological system of non-pregnant women of child-bearing age was associated with breakthrough of LPS in systemic bloodstream. Registration of vaginosis during pregnancy associated with detection of Chlamydia, possessing LPS similar to enterobacteria, revealed presence of unfavorable variants of prolonged torpid course of dysbiotic signs.


CONCLUSIONS
During torpid forms of bacterial vaginosis, entotoxinemia and abnormalities in anti-endotoxin immunity are revealed, which the need of optimization of its therapy.
Mavziutov
A R
AR
Bondarenko
K R
KR
Bondarenko
V M
VM
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D002352:Carrier Proteins / Q000097:blood / Q000276:immunology; D002692:Chlamydia trachomatis / Q000276:immunology*; D019446:Endotoxemia / Q000276:immunology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008070:Lipopolysaccharides / Q000276:immunology* / Q000378:metabolism; D011247:Pregnancy; D016585:Vaginosis, Bacterial / Q000097:blood / Q000276:immunology*
D000907:Antibodies, Bacterial; D002352:Carrier Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008070:Lipopolysaccharides