Association of a progesterone receptor gene +331 G/A polymorphism with breast cancer risk: a meta-analysis.
Published studies on the association between the progesterone receptor gene +331 G/A polymorphism and breast cancer risk are inconclusive, and meta-analysis is required to verify the association. Six studies, including a total of 6,849 cases and 6,589 controls, were subjected to meta-analysis. When all eligible subjects were pooled for meta-analysis, the AG + AA variant genotype was not associated with a significantly elevated breast cancer risk [odds ratio (OR) = 1.11; 95% confidence interval (95%CI) = 0.99-1.24; P = 0.071]. However, subgroup analysis revealed that the AG + AA variant genotype was associated with an increased risk of breast cancer in American (OR = 1.32; 95%CI = 1.10-1.58; P = 0.003), but not in European or Australian. We could carefully suggest that the progesterone receptor promoter +331 G/A variant polymorphism might increase breast cancer risk, and this effect appeared to be more prominent in Americans than in Europeans and Australians.
Yang
Dae Sik
DS
Department of Radiation Oncology, Medical College, Korea University, Seoul, Korea.
Sung
Hwa Jung
HJ
Woo
Ok Hee
OH
Park
Kyong Hwa
KH
Woo
Sang Uk
SU
Kim
Ae-Ree
AR
Lee
Eun Sook
ES
Lee
Jae-Bok
JB
Kim
Yeul Hong
YH
Kim
Jun Suk
JS
Seo
Jae Hong
JH
D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D011980:Receptors, Progesterone / Q000235:genetics*
D011980:Receptors, Progesterone