Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps.
OBJECTIVE
Metabolic syndrome and insulin resistance are associated with a higher risk of colon cancer. Non-alcoholic fatty liver disease (NAFLD) is regarded as a manifestation of metabolic syndrome in the liver. This investigation was initiated to determine whether NAFLD has a relationship to colorectal adenomatous polyps.


METHODS
We examined the 2917 participants who underwent a routine colonoscopy at Kangbuk Samsung Hospital in 2007. We divided the 2917 subjects into the adenomatous polyp group (n = 556) and the normal group (n = 2361). Anthropometric measurements, biochemical tests for liver and metabolic function, and abdominal ultrasonographs were assessed.


RESULTS
The prevalence of NAFLD was 41.5% in the adenomatous polyp group and 30.2% in the control group. By multiple logistic regression analysis, NAFLD was found to be associated with an increased risk of colorectal adenomatous polyps (odds ratio, 1.28; 95% confidence interval, 1.03-1.60). An increased risk for NAFLD was more evident in patients with a greater number of adenomatous polyps.


CONCLUSIONS
NAFLD was associated with colorectal adenomatous polyps. Further studies are needed to confirm whether NAFLD is a predictor for the development of colorectal adenomatous polyps and cancer.
Hwang
Sang Tae
ST
Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, South Korea.
Cho
Yong Kyun
YK
Park
Jung Ho
JH
Kim
Hong Joo
HJ
Park
Dong Il
DI
Sohn
Chong Il
CI
Jeon
Woo Kyu
WK
Kim
Byung Ik
BI
Won
Kyoung Hee
KH
Jin
Wook
W
D018256:Adenomatous Polyps / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D005234:Fatty Liver / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D005235:Fatty Liver, Alcoholic / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications; D008875:Middle Aged; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D018709:Statistics, Nonparametric