title: Percutaneous coronary intervention in heavily calcified lesions using rotational atherectomy and paclitaxel-eluting stents: outcomes at one year.
abstract: Heavily calcified lesions present a challenge for percutaneous coronary intervention. With rotational atherectomy, it is possible to treat these lesions and paclitaxel-eluting stents (PESs) reduce the risk of restenosis over the long term. This retrospective study investigated clinical outcomes with rotational atherectomy and PESs in 50 consecutive patients with heavily calcified lesions. Mortality and target lesion revascularization at 1 year (median, 14 months; interquartile range, 8.75-25.5 months) were recorded. Some 52% of patients were aged over 70 years, 68% were male, 52% had acute coronary syndrome, 80% had multivessel disease and 44% were receiving abciximab. Two patients died in hospital, three died during follow-up (one cardiac death) and 3 (6%) underwent target lesion revascularization. At 1 year, the survival rate free of cardiac death was 94% and the survival rate free of target lesion revascularization was 94%. These findings demonstrate that the combination of rotational atherectomy and PESs gives excellent results in heavily calcified lesions.
authors.affiliation: Unidad de Hemodinámica, Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain. garciadelara@secardiologia.es
authors.forename: Juan
authors.initials: J
authors.lastname: García de Lara
authors.forename: Eduardo
authors.initials: E
authors.lastname: Pinar
authors.forename: Juan
authors.initials: J
authors.lastname: Ramón Gimeno
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Hurtado
authors.forename: Javier
authors.initials: J
authors.lastname: Lacunza
authors.forename: Raúl
authors.initials: R
authors.lastname: Valdesuso
authors.forename: Mariano
authors.initials: M
authors.lastname: Valdés Chávarri
mesh_terms: D000368:Aged; D017225:Atherectomy, Coronary; D002114:Calcinosis / Q000150:complications* / Q000601:surgery*; D003324:Coronary Artery Disease / Q000150:complications* / Q000601:surgery*; D003327:Coronary Disease / Q000150:complications / Q000601:surgery; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D017239:Paclitaxel