[Therapeutic effect of anti-anaphylaxis granule on chronic urticaria and its impact on serum levels of RANTES].
OBJECTIVE
To investigate the therapeutic effect of Anti-anaphylaxis Granule (AAG) on chronic urticaria and its impact on cytokine of regulated upon activation of normal T cells expressed and secreted (RANTES), eosinophil chemotactic factor (Eotaxin) and tumor necrosis factor-alpha (TNF-alpha).


METHODS
The therapeutic effects of AAG and cetirizine on chronic urticaria patients allocated in two groups were observed respectively, and the serum levels of RANTES, Eotaxin and TNF-alpha in patients were measured by ELISA before and after treatment, and were compared with those in normal subjects.


RESULTS
The therapeutic effects of AAG group were better in effective rate (88.5% vs 64.0%) and lower in the recurrent rate (5.6% vs 41.9%) than those cetirizine (all P<0.05). Serum levels of RANTES, Eotaxin and TNF-alpha in patients were higher than those in normal subjects (P<0.01), and they could be significantly reduced after AAG treatment (P<0.01).


CONCLUSIONS
AAG has favorite effect for treatment of chronic urticaria, its regulation on serum levels of RANTES, Eotaxin and TNF-alpha may be the mechanism of action.
Shi
Li-Hong
LH
Department of Pharmacology, Weifang Medical University, Shandong, China. shilih@163.com
Fang
Chun-Yan
CY
Li
Xiao-Min
XM
D000293:Adolescent; D000328:Adult; D017332:Cetirizine / Q000627:therapeutic use; D054413:Chemokine CCL11 / Q000097:blood; D018946:Chemokine CCL5 / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D044967:Serum / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014581:Urticaria / Q000097:blood* / Q000188:drug therapy*; D055815:Young Adult
C483024:CCL5 protein, human; D054413:Chemokine CCL11; D018946:Chemokine CCL5; D004365:Drugs, Chinese Herbal; D014409:Tumor Necrosis Factor-alpha; D017332:Cetirizine