title: Practical and efficient synthesis of pyrano[3,2-c]pyridone, pyrano[4,3-b]pyran and their hybrids with nucleoside as potential antiviral and antileishmanial agents.
abstract: A highly practical and efficient preparation of pyrano[3,2-c]pyridone and pyrano[4,3-b]pyran derivatives was developed via an ionic liquid mediated and promoted multi-component reaction of aldehyde (1), 4-hydroxy-pyridin-2(1H)-one or 4-hydroxy-2-pyranone (2), and malononitrile (3). As an application, a series of pyrimidine nucleoside-pyrano[3,2-c]pyridone or pyrano[4,3-b]pyran hybrids were efficiently obtained. These hybrid compounds were evaluated as potential antiviral and antileishmanial agents and showed encouraging biological activities.
authors.affiliation: School of Chemistry and Environmental Sciences, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang, Henan 453007, PR China.
authors.forename: Xuesen
authors.initials: X
authors.lastname: Fan
authors.forename: Dong
authors.initials: D
authors.lastname: Feng
authors.forename: Yingying
authors.initials: Y
authors.lastname: Qu
authors.forename: Xinying
authors.initials: X
authors.lastname: Zhang
authors.forename: Jianji
authors.initials: J
authors.lastname: Wang
authors.forename: Philippe M
authors.initials: PM
authors.lastname: Loiseau
authors.forename: Graciela
authors.initials: G
authors.lastname: Andrei
authors.forename: Robert
authors.initials: R
authors.lastname: Snoeck
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D007893:Leishmania donovani / Q000187:drug effects / Q000502:physiology; D009705:Nucleosides / Q000138:chemical synthesis / Q000494:pharmacology; D011714:Pyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D011728:Pyridones / Q000138:chemical synthesis* / Q000494:pharmacology; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000981:Antiprotozoal Agents; D000998:Antiviral Agents; D009705:Nucleosides; D011714:Pyrans; D011728:Pyridones; D011741:Pyrimidine Nucleosides