title: [Proteomics studies on arthritis by SELDI-TOF-MS: identification of the S100 proteins family as proteins of interest].
abstract: Clinical proteomics is a technical approach studying the entire proteome expressed by cells, tissues or organs. It describes the dynamics of cell regulation by detecting molecular events related to diseases development. Proteomic techniques focus mainly on identification of new biomarkers or new therapeutic targets. It is a multidisciplinary approach using medical, biological, bioanalytical and bioinformatics knowledges. A strong collaboration between these fields allowed SELDI-TOF-MS proteomics studies to be performed at the CHU and the University of Liège, in GIGA-Research facilities. The aim of these studies was driven along three main axes of research related to the identification of biomarkers specific to a studied pathology, to a common biological pathway and, finally, to a treatment response. This work was presented in the setting of the "Synthèse CHU 2009" meeting.
authors.affiliation: Service de Rhumatologie, CHU de Liège, Liège, Belgique. ddeseny@chu.ulg.ac.be
authors.forename: D
authors.initials: D
authors.lastname: De Seny
authors.forename: C
authors.initials: C
authors.lastname: Ribbens
authors.forename: G
authors.initials: G
authors.lastname: Cobraiville
authors.forename: M A
authors.initials: MA
authors.lastname: Meuwis
authors.forename: R
authors.initials: R
authors.lastname: Marée
authors.forename: P
authors.initials: P
authors.lastname: Geurts
authors.forename: L
authors.initials: L
authors.lastname: Wehenkel
authors.forename: E
authors.initials: E
authors.lastname: Louis
authors.forename: M P
authors.initials: MP
authors.lastname: Merville
authors.forename: M
authors.initials: M
authors.lastname: Fillet
authors.forename: M G
authors.initials: MG
authors.lastname: Malaise
mesh_terms: D001168:Arthritis / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D006801:Humans; D040901:Proteomics; D009418:S100 Proteins / Q000097:blood*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D015415:Biomarkers; D009418:S100 Proteins