Polycyclic polyprenylated acylphloroglucinols and chromone O-glucosides from Hypericum henryi subsp. uraloides.
Two new C(30)-epimeric polycyclic polyprenylated acylphloroglucinols (PPAPs), named uralodins B and C (1 and 2, resp.), were isolated from the aerial parts of Hypericum henryi subsp. uraloides together with two new chromone glucosides, urachromones A and B (3 and 4, resp.), as well as 16 known compounds. Their structures were established by extensive NMR techniques and MS analysis. The epimers 1 and 2 always behaved like a single compound when examined by TLC, and were separated by HPLC. Their configuration was distinguished by comparative analysis of the NMR data with known analogues together with the ROESY experiment. All the isolated PPAPs were evaluated for their cytotoxic activities against HepG2, SGC7901, HL-60, and K562 cell lines. Compound 1 showed modest cytotoxic activities against SGC7901 and HL-60 cell lines, and 2 showed modest cytotoxic activities against HepG2, SGC7901, HL-60, and K562 cell lines.
Chen
Xuan-Qin
XQ
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P R China.
Li
Yan
Y
Cheng
Xiao
X
Wang
Kou
K
He
Juan
J
Pan
Zheng-Hong
ZH
Li
Ming-Ming
MM
Peng
Li-Yan
LY
Xu
Gang
G
Zhao
Qin-Shi
QS
D045744:Cell Line, Tumor; D002867:Chromones / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D018922:HL-60 Cells; D056945:Hep G2 Cells; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D020014:K562 Cells; D008968:Molecular Conformation; D010696:Phloroglucinol / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
D002867:Chromones; D005960:Glucosides; D010696:Phloroglucinol