Prediction of infectious events by high-sensitivity C-reactive protein level before undergoing chemotherapy for acute myeloid leukaemia.
We retrospectively evaluated the serum high-sensitivity C-reactive protein (CRP) level before chemotherapy for the prediction of infectious events during neutropenia in patients with acute myeloid leukaemia. Thirty-eight patients who underwent first induction chemotherapy and 37 patients who underwent first consolidation chemotherapy were analyzed separately. A receiver-operating characteristic (ROC) curve revealed that the serum CRP level just before the first consolidation chemotherapy, but not just before the induction chemotherapy, had a significant predictive value for febrile neutropenia (FN) at a cut-off value of 0.19 mg/dl and documented infection (DI) at a cut-off value of 0.26 mg/dl. The high-sensitivity CRP measurement enabled the detection of slight increases in the serum CRP level, which might reflect a minute inflammation by occult infection, and discriminated high-risk patients for infectious events.
Sato
Miki
M
Division of Haematology, Saitama Medical Centre, Jichi Medical University, 1-847 Amanuma, Omiya-ku, Saitama, Japan.
Kako
Shinichi
S
Oshima
Kumi
K
Sato
Ken
K
Terasako
Kiriko
K
Kimura
Shun-Ichi
S
Nakasone
Hideki
H
Okuda
Shinya
S
Yamazaki
Rie
R
Higuchi
Takakazu
T
Nishida
Junji
J
Kanda
Yoshinobu
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis*; D004358:Drug Therapy; D005260:Female; D005544:Forecasting / Q000379:methods*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000453:epidemiology*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult
D002097:C-Reactive Protein