Morphological findings in bone marrow biopsy and aspirate smears of visceral Kala Azar: a review.
BACKGROUND
Visceral leishmaniasis (VL) is endemic in India and may simulate and cause many hematological disorders like pancytopenia, myelofibrosis, myelodysplasia and hemophagocytosis.


OBJECTIVE
The study aims to investigate the hematological manifestation of Visceral Leishmaniasis and associated changes that may be observed in bone marrow aspirate smears and biopsy which may warn a pathologist of possible infections.


METHODS
This is a retrospective study of 18 VL cases on B (b) one marrow aspirate and biopsy in the department of Pathology in a tertiary care teaching hospital in New Delhi.


METHODS
Giemsa stained slides of bone marrow aspirates and hematoxylin and Eosin stained biopsy slides were reviewed in detail by two competent pathologists. All the findings were tabulated and discussed and comparisons made with the previous similar studies.


RESULTS
Hyper cellular marrow, increased lymphocytes and plasma cells, marrow granulomas, hemophagocytosis, myelofibrosis, myelodysplasia and gelatinous transformation of the marrow were notable features the presence of which together or individually should caution a pathologist to search for Leishman Donovan (LD) bodies in patients especially in a non-endemic zone in a tropical country.
Dhingra
Kajal Kiran
KK
Department of Pathology, Maulana Azad Medical College and Lok Nayak Hospital, Bahadur Shah Zafar Marg, New Delhi 110 002, India.
Gupta
Parul
P
Saroha
Vijay
V
Setia
Namrata
N
Khurana
Nita
N
Singh
Tejinder
T
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D006651:Histocytochemistry / Q000379:methods; D006784:Hospitals, Teaching; D006801:Humans; D007194:India; D007898:Leishmaniasis, Visceral / Q000473:pathology*; D008297:Male; D008853:Microscopy / Q000379:methods; D012189:Retrospective Studies; D055815:Young Adult