title: Real-time monitoring of drug release.
abstract: A new prodrug system, assembled using a distinctive coumarin linker, was demonstrated to report real-time activation and drug release in vitro.
authors.affiliation: School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv 69978, Israel.
authors.forename: Roy
authors.initials: R
authors.lastname: Weinstain
authors.forename: Ehud
authors.initials: E
authors.lastname: Segal
authors.forename: Ronit
authors.initials: R
authors.lastname: Satchi-Fainaro
authors.forename: Doron
authors.initials: D
authors.lastname: Shabat
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage* / Q000494:pharmacology; D015394:Molecular Structure; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003374:Coumarins; D011355:Prodrugs; C030123:coumarin; D008558:Melphalan