[SSRI antidepressants and negative schizophrenic symptoms: differences between paroxetine and fluvoxamine in patients treated with olanzapine].
BACKGROUND
After the advent of SSRI, antidepressants in low doses and in combination with neuroleptic treatment entered into use in clinical practice. The indication is the depression that may overlap with schizophrenic disorder.


OBJECTIVE
Our work, based on "serotonin dimension" of schizophrenic disorder and accepting the neuropharmacological paradox that is cotherapy antipsicotic drug/SSRI, has investigated two different combinations of integrated treatment: olanzapine+paroxetine and olanzapine+fluvoxamine.


METHODS
The study sample consists of 50 patients with schizophrenia, all young adults aged up to 36 years. The therapeutic groups were structured as a term of one year, with scales by SANS and PANSS at time 0, 1 months, 6 months and 12 months. RESULTS; The clinical evidence has shown good parameters of efficacy, safety and tolerability of the drug SSRI in combination with neuroleptics. There was a reduction in negative symptoms, as evidenced by the decrease in scoring in the PANSS and SANS scales. This is especially valid for the molecule fluvoxamine.


CONCLUSIONS
While the molecule paroxetine seems partly slatentize cognitive deficits (expression of residual psychotic negative component), fluvoxamine has proven effective in improving the negative symptoms and has shown, moreover, not to increase the positive symptoms of the disease.
Rusconi
Anna Carlotta
AC
Day Hospital Psichiatrico, Dipartimento di Scienze Psichiatriche e Medicina Psicologica, Sapienza Università di Roma. kriskarl@hotmail.it
Carlone
Cristiano
C
Muscillo
Marco
M
Coccanari de' Fornari
Maria Antonietta
MA
Podda
Livia
L
Piccione
Michele
M
D000328:Adult; D001569:Benzodiazepines / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D016666:Fluvoxamine / Q000627:therapeutic use*; D006801:Humans; D000077152:Olanzapine; D017374:Paroxetine / Q000627:therapeutic use*; D012559:Schizophrenia / Q000175:diagnosis* / Q000188:drug therapy*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
D001569:Benzodiazepines; D016666:Fluvoxamine; D000077152:Olanzapine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors