The role of mTOR signaling in controlling mammalian life span: what a fungicide teaches us about longevity.
Sharp
Zelton Dave
ZD
Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245, USA. sharp@uthscsa.edu
Strong
Randy
R
D000375:Aging / Q000378:metabolism / Q000502:physiology; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D049109:Cell Proliferation; D004194:Disease / Q000209:etiology; D004334:Drug Administration Schedule; D005853:Geriatrics / Q000379:methods; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D008136:Longevity / Q000187:drug effects* / Q000502:physiology*; D008659:Metabolic Diseases / Q000209:etiology; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D011322:Primary Prevention / Q000379:methods; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D020123:Sirolimus / Q000008:administration & dosage / Q000494:pharmacology*; D058570:TOR Serine-Threonine Kinases
D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D047908:Intracellular Signaling Peptides and Proteins; C546842:MTOR protein, human; D017346:Protein Serine-Threonine Kinases; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus