title: Blood inflammatory proteins and risk of incident depression in the elderly.
abstract: BACKGROUND
  It is unclear whether high levels of blood inflammatory proteins are associated with the risk of developing depression in late life.
  
  
  METHODS
  Blood C-reactive protein, interleukin (IL)-6, 1 -antichymotrypsin (ACT), intercellular adhesion molecule 1, and tumor necrosis factor were measured in an elderly cohort (n = 968). Major depression diagnosed according to clinical criteria and relevant depressive symptoms measured by the Geriatric Depression Scale (score 6 10) were assessed at baseline and 4 year later.
  
  
  RESULTS
  Baseline IL-6 and ACT were increased in both prevalent major depression and relevant depressive symptoms. Baseline ACT was increased in incident major depression. All associations weakened below significance after adjustment for possible confounders and multiple comparisons.
  
  
  CONCLUSIONS
  Blood inflammatory proteins do not predict the risk of developing depression in older age.
authors.affiliation: Department of Internal Medicine, Ageing, and Nephrology, University Hospital St. Orsola-Malpighi, Bologna, Italy. paola.forti@unibo.it
authors.forename: Paola
authors.initials: P
authors.lastname: Forti
authors.forename: Elisa
authors.initials: E
authors.lastname: Rietti
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Pisacane
authors.forename: Valentina
authors.initials: V
authors.lastname: Olivelli
authors.forename: Erminia
authors.initials: E
authors.lastname: Mariani
authors.forename: Martina
authors.initials: M
authors.lastname: Chiappelli
authors.forename: Federico
authors.initials: F
authors.lastname: Licastro
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ravaglia
mesh_terms: D000368:Aged / Q000523:psychology*; D015331:Cohort Studies; D003863:Depression / Q000097:blood* / Q000453:epidemiology / Q000523:psychology*; D003865:Major Depressive Disorder / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007558:Italy / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D015233:Models, Statistical; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales
chemical_list: D018836:Inflammation Mediators