Outbreak of echovirus 18 meningitis in a rural Missouri community.
This is a case-control study of viral meningitis outbreak in Perry County, Missouri. All case-patients had viral meningitis per routine CSF analysis or PCR testing. Enterovirus VP1-specific RT-PCR and sequencing was performed on CSF. Univariate and multivariable logistic regression analysis was done to evaluate risk factors. The meningitis attack rate was 1/1,000 population. The main risk factor for meningitis was association with childcare. In patients with signs of meningitis, but normal routine CSF analysis, molecular testing of the CSF is helpful for conclusive diagnosis.
Turabelidze
George
G
Missouri Department of Health and Senior Services, Jefferson City, MO, USA. George.Turabelidze@dhss.mo.gov
Lin
Mei
M
Butler
Cindy
C
Fick
Frank
F
Russo
Tony
T
D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002656:Child Day Care Centers; D002675:Child, Preschool; D004196:Disease Outbreaks; D004457:Echovirus Infections / Q000134:cerebrospinal fluid / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid / Q000453:epidemiology*; D008923:Missouri; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D012424:Rural Population; D017678:Sex Distribution; D014776:Virus Cultivation