Reinfection rate and endoscopic changes after successful eradication of Helicobacter pylori.
OBJECTIVE
To determine the long-term outcomes regarding reinfection with Helicobacter pylori (H. pylori) and endoscopic changes after successful H. pylori eradication.


METHODS
From June 1994 to January 2007, 186 patients (M:F = 98:88; mean age 50.0 +/- 11.4 years), in whom H. pylori had been successfully eradicated, were enrolled. The mean duration of follow up was 41.2 +/- 24.0 mo.


RESULTS
H. pylori reinfection occurred in 58 patients (31.2%). The average annual reinfection rate was 9.1% per patient year. No recurrence of peptic ulcer was detected at the follow up endoscopy. There were no significant differences between the H. pylori eradication regimens for the reinfection rate and no significant differences in endoscopic findings between the H. pylori-recurred group and the H. pylori-cured group.


CONCLUSIONS
The reinfection rate in Korea is 9.1% which represents a decreasing trend. There was no relationship between H. pylori infection status and changes in endoscopic findings. There was also no recurrence or aggravation of ulcers.
Ryu
Kum Hei
KH
Center for Cancer Prevention and Detection, National Cancer Center, Madu1-dong, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-769, South Korea.
Yi
Sun Young
SY
Na
Youn Ju
YJ
Baik
Su Jung
SJ
Yoon
Su Jin
SJ
Jung
Hae-Sun
HS
Song
Hyun Joo
HJ
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005500:Follow-Up Studies; D016481:Helicobacter Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology*; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D012008:Recurrence; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies
D000900:Anti-Bacterial Agents