Powering reprogramming with vitamin C.
In this issue of Cell Stem Cell, Esteban et al. (2009) report that vitamin C enhances the reprogramming efficiency of mouse and human fibroblasts transduced with three (Oct4/Klf4/Sox2) or four (Oct4/Klf4/Sox2/cMyc) factors. Vitamin C can alleviate cell senescence by p53 repression and may accelerate reprogramming by synergizing with epigenetic regulators.
Shi
Yan
Y
Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen 518055, China.
Zhao
Yang
Y
Deng
Hongkui
H