title: (-)-Bacillamide C: the convergent approach.
abstract: The newly discovered natural product bacillamide C and several derivatives were convergently synthesized for the first time and in only three steps. The key transformation constitutes a thiazole Ugi multicomponent reaction. These compounds will serve to elucidate chemical biology and SAR of this potent anti-algae natural product and shows the synthetic pathway to related natural products.
authors.affiliation: University of Pittsburgh, Drug Discovery Institute, Pittsburgh, PA 15261, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Shannon
authors.initials: S
authors.lastname: Joyner
authors.forename: Kareem Andrew Sameer
authors.initials: KA
authors.lastname: Khoury
authors.forename: Alexander
authors.initials: A
authors.lastname: Dömling
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D007700:Kinetics; D013237:Stereoisomerism; D013379:Substrate Specificity; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D014363:Tryptamines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D001688:Biological Products; D013844:Thiazoles; D014363:Tryptamines; C525340:bacillamide C