RECQL5 helicase: connections to DNA recombination and RNA polymerase II transcription.
The RecQ family of helicases are traditionally viewed as recombination factors, important for maintaining genome stability. RECQL5 is unique among these proteins in being associated with RNA polymerase II, the enzyme responsible for transcribing all protein-encoding genes in eukaryotes. Here, we describe the possible implications of recent studies and discuss models for RECQL5 function.
Aygün
Ozan
O
Mechanisms of Transcription Laboratory, Clare Hall Laboratories, Cancer Research UK London Research Institute, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, United Kingdom.
Svejstrup
Jesper Q
JQ
D000818:Animals; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D042822:Genomic Instability; D006801:Humans; D012319:RNA Polymerase II / Q000378:metabolism*; D053484:RecQ Helicases / Q000737:chemistry / Q000378:metabolism*; D011995:Recombination, Genetic; D014158:Transcription, Genetic
D004247:DNA; D012319:RNA Polymerase II; D053484:RecQ Helicases