Does sudden unexpected death in children with epilepsy occur more frequently in those with high seizure frequency?
People with epilepsy are more likely to die prematurely and the most common epilepsy-related category of death is sudden unexpected death in epilepsy (SUDEP). Several studies have reported a moderate or high seizure frequency among SUDEP cases and SUDEP is considered rare in patients in remission.


METHODS
We reviewed the occurrence of SUDEP in our epilepsy unit over an 8-year period to identify a potential association between seizure frequency and SUDEP occurrence in children with epilepsy.


RESULTS
From 835 patients evaluated, 12 had suffered SUDEP and nearly all of the SUDEP cases in our children are related to chronic uncontrolled epilepsy (daily--50.0%, two to four/week--41.7%, monthly--8.3%).


CONCLUSIONS
SUDEP is not a rare event in children and increased mortality was recorded in those individuals who had not responded to pharmacologic treatment. Improved seizure control seems to be one of the most important measures to prevent SUDEP.
Terra
Vera C
VC
Departamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
Scorza
Fulvio A
FA
Sakamoto
Américo C
AC
Pinto
Kylvia G F D
KG
Fernandes
Regina M F
RM
Arida
Ricardo M
RM
Cavalheiro
Esper A
EA
Machado
Hélio R
HR
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003645:Death, Sudden / Q000453:epidemiology / Q000209:etiology*; D004827:Epilepsy / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D012640:Seizures / Q000517:prevention & control; D012720:Severity of Illness Index