The right team at the right time to go for a home run: tyrosine kinase activation by the TCR.
The TCR signals via cytoplasmic tyrosine kinases. Art Weiss recounts discoveries that led to early understanding of these events.
Weiss
Arthur
A
Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, Departments of Medicine and of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA. aweiss@medicine.ucsf.edu
D000486:Allergy and Immunology / Q000266:history*; D004789:Enzyme Activation / Q000502:physiology*; D005260:Female; D049673:History, 20th Century; D006801:Humans; D011505:Protein-Tyrosine Kinases / Q000276:immunology / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology*
D011948:Receptors, Antigen, T-Cell; D011505:Protein-Tyrosine Kinases