Higher fibrinogen levels predict progression of coronary artery calcification in adults with type 1 diabetes.
OBJECTIVE
To determine whether fibrinogen levels predict independently progression of coronary artery calcification (CAC) in adults with type 1 diabetes.


METHODS
Data from a prospective cohort--the Coronary Artery Calcification in Type 1 Diabetes Study--were evaluated. Fibrinogen levels at baseline were separated into quartiles. CAC was measured twice and averaged at baseline and at follow-up 2.4+/-0.4 years later. CAC progressors were defined as participants whose square-root transformed CAC volume increased by >or=2.5 mm3 or development of clinical coronary artery disease during the follow-up period.


RESULTS
Fibrinogen levels were higher in progressors than in non-progressors (276+/-61 mg/dl versus 259+/-61 mg/dl, p=0.0003). CAC progression, adjusted for known cardiovascular risk factors, increased in the highest quartile.


CONCLUSIONS
Higher fibrinogen levels predict CAC progression in type 1 diabetes subjects, independent of standard cardiovascular risk factors.
Rodrigues
T C
TC
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Health Sciences Center, Aurora CO 80045, USA. ticianacr@yahoo.com.br
Snell-Bergeon
J K
JK
Maahs
D M
DM
Kinney
G L
GL
Rewers
M
M
D000328:Adult; D002114:Calcinosis / Q000097:blood* / Q000473:pathology; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000473:pathology; D048909:Diabetes Complications / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D018450:Disease Progression; D005260:Female; D005340:Fibrinogen / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors
D005340:Fibrinogen