title: Antibacterial activity of poly(vinyl alcohol)-b-poly(acrylonitrile) based micelles loaded with silver nanoparticles.
abstract: A new amphiphilic poly(vinyl alcohol)-b-poly(acrylonitrile) (PVOH-b-PAN) copolymer obtained by selective hydrolysis of well-defined poly(vinyl acetate)-b-poly(acrylonitrile) copolymer synthesized by cobalt mediated radical polymerization was used for the preparation of PVOH-b-PAN based micelles with embedded silver nanoparticles. The successful formation of silver loaded micelles has been confirmed by UV-vis, DLS and TEM analysis and their antibacterial activity against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa) and spore solution of Bacillus subtilis (B. subtilis) has been studied. PVOH-b-PAN based micelles with embedded silver nanoparticles showed a strong bactericidal effect against E. coli, S. aureus and P. aeruginosa and the minimum bactericidal concentration for each system (MBC) has been determined.
authors.affiliation: University of Chemical Technology and Metallurgy, Department Polymer Engineering, 8 Kl.Ohridski, 1756 Sofia, Bulgaria. rbryaskova@uctm.edu
authors.forename: Rayna
authors.initials: R
authors.lastname: Bryaskova
authors.forename: Daniela
authors.initials: D
authors.lastname: Pencheva
authors.forename: Mariya
authors.initials: M
authors.lastname: Kyulavska
authors.forename: Dimitriya
authors.initials: D
authors.lastname: Bozukova
authors.forename: Antoine
authors.initials: A
authors.lastname: Debuigne
authors.forename: Christophe
authors.initials: C
authors.lastname: Detrembleur
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006868:Hydrolysis; D053768:Metal Nanoparticles / Q000737:chemistry*; D008823:Micelles; D008826:Microbial Sensitivity Tests; D010316:Particle Size; D011145:Polyvinyls / Q000737:chemistry* / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D008823:Micelles; D011145:Polyvinyls; C544705:poly(vinyl alcohol)-b-poly(acrylonitrile); D012834:Silver