Integrins and mutant p53 on the road to metastasis.
Understanding how tumor cells invade tissues is key to developing drugs to block metastasis. In this issue, Muller et al. (2009) report that a mutant form of the tumor suppressor p53 in cancer cells boosts the endocytic recycling of the adhesion molecule integrin alpha5beta1 and of epidermal growth factor receptor, promoting invasion and metastasis.
Selivanova
Galina
G
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 17177, Sweden.
Ivaska
Johanna
J
D000818:Animals; D066246:ErbB Receptors / Q000378:metabolism; D006801:Humans; D039081:Integrin alpha5beta1 / Q000378:metabolism*; D051379:Mice; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D039081:Integrin alpha5beta1; D016159:Tumor Suppressor Protein p53; D066246:ErbB Receptors