title: TCF1 and beta-catenin regulate T cell development and function.
abstract: T cell factor-1 (TCF1) critically regulates T cell development. However, signals that control TCF1 function in developing and mature T cells remain unknown. TCF1 along with beta-catenin activates gene transcription and in cooperation with Groucho family of proteins mediates gene repression. It has been established that the beta-catenin-dependent gene expression is often downstream of the canonical Wnt signaling pathway. We have genetically manipulated the beta-catenin gene and generated mutant mice that have shown an essential role for beta-catenin and TCF1 during pre-T cell receptor (TCR) and TCR-dependent stages of T cell development. We have also demonstrated a function for TCF1 and beta-catenin downstream of TCR signaling in the differentiation of mature CD4 T cells into T helper lineages.
authors.affiliation: Lymphocyte Development Unit, Laboratory of Immunology, National Institute on Aging, National Institutes of Health, BRC Building, 8C218, Baltimore, MD 21224, USA.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yu
authors.forename: Archna
authors.initials: A
authors.lastname: Sharma
authors.forename: Jyoti Misra
authors.initials: JM
authors.lastname: Sen
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D051822:T Cell Transcription Factor 1 / Q000235:genetics / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
chemical_list: D011948:Receptors, Antigen, T-Cell; D051822:T Cell Transcription Factor 1; D051176:beta Catenin