Preimplantation genetic diagnosis (PGD) for HLA typing: bases for setting up an open international collaboration when PGD is not available.
In severe forms of Diamond-Blackfan anemia, preimplantation genetic diagnosis (PGD) of histocompatibility leukocyte antigen-compatible embryos for enabling the next sibling in the family to be a stem-cell transplantation donor constitutes the sole lasting cure capable of terminating the enduring need for iterative transfusions. We report here an open collaboration between two renowned institutions to provide a family desiring this treatment even though they resided where the preimplantation genetic diagnosis procedure is banned.
Bellavia
Marina
M
Reproductive Endocrinology and Infertility, Department of Gynecology-Obstetrics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Von Der Weid
Nicolas
N
Peddes
Christina
C
Jacquemont
Sebastien
S
Liebaers
Inge
I
Hohlfeld
Patrick
P
Wunder-Galié
Dorothea
D
de Ziegler
Dominique
D
D000328:Adult; D029503:Anemia, Diamond-Blackfan / Q000628:therapy; D002648:Child; D033001:Directed Tissue Donation / Q000331:legislation & jurisprudence; D005260:Female; D005307:Fertilization in Vitro; D006297:Health Services Accessibility / Q000331:legislation & jurisprudence; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D007391:International Cooperation; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000379:methods / Q000706:statistics & numerical data*; D012801:Sibling Relations; D035781:Siblings; D033581:Stem Cell Transplantation / Q000379:methods; D013557:Switzerland; D014184:Transplantation, Homologous