title: Further diffusion tensor imaging contribution in horizontal gaze palsy and progressive scoliosis.
abstract: In two siblings with clinical diagnosis of horizontal gaze palsy associated with progressive scoliosis (HGPPS) we could demonstrate by diffusion tensor imaging: (1) An anterior displacement of the transverse pontine fibers; (2) Posterior clumping of the corticospinal, medial lemniscus and central tegmental tracts and of the medial and dorsal longitudinal fasciculi complex; (3) Absent decussation of superior cerebellar peduncle. Those findings can contribute as surrogate markers for the diagnosis.
authors.affiliation: Department of Radiology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Maria Conceptión García
authors.initials: MC
authors.lastname: Otaduy
authors.forename: Claudia da Costa
authors.initials: Cda C
authors.lastname: Leite
authors.forename: Lídia Mayumi
authors.initials: LM
authors.lastname: Nagae
authors.forename: Marco da Cunha
authors.initials: Mda C
authors.lastname: Pinho
authors.forename: Clarissa
authors.initials: C
authors.lastname: Bueno
authors.forename: Umbertina Conti
authors.initials: UC
authors.lastname: Reed
authors.forename: Fernando
authors.initials: F
authors.lastname: Kok
mesh_terms: D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D015835:Ocular Motility Disorders / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D011149:Pons / Q000473:pathology; D012600:Scoliosis / Q000150:complications / Q000175:diagnosis*