title: A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia.
abstract: The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18,920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 x 10(-5)-1.7 x 10(-3), common OR = 1.09-1.11). The region contains two genes, AHI1 and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.
authors.affiliation: Research Institute of Biological Psychiatry, Copenhagen University Hospital, Roskilde, Denmark. andres.ingason@shh.regionh.dk
authors.forename: Andrés
authors.initials: A
authors.lastname: Ingason
authors.forename: Ina
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authors.lastname: Giegling
authors.forename: Sven
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authors.lastname: Cichon
authors.forename: Thomas
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authors.lastname: Rasmussen
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authors.lastname: Strengman
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authors.lastname: Melle
authors.forename: Bernard
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authors.initials: HJ
authors.lastname: Möller
authors.forename: Clyde
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authors.lastname: Pietiläinen
authors.forename: Jouko
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authors.forename: Jaana
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authors.lastname: Suvisaari
authors.forename: Annamari
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authors.lastname: Tuulio-Henriksson
authors.forename: Muriel
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authors.lastname: Walshe
authors.forename: Evangelos
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authors.lastname: Vassos
authors.forename: Marta
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authors.lastname: Di Forti
authors.forename: Robin
authors.initials: R
authors.lastname: Murray
authors.forename: Chiara
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authors.lastname: Bonetto
authors.forename: Sarah
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authors.lastname: Tosato
authors.forename: Rita M
authors.initials: RM
authors.lastname: Cantor
authors.forename: Marcella
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authors.lastname: Rietschel
authors.forename: Nick
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authors.lastname: Craddock
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owen
authors.forename: Leena
authors.initials: L
authors.lastname: Peltonen
authors.forename: Ole A
authors.initials: OA
authors.lastname: Andreassen
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: David
authors.initials: D
authors.lastname: St Clair
authors.forename: Roel A
authors.initials: RA
authors.lastname: Ophoff
authors.forename: Michael C
authors.initials: MC
authors.lastname: O'Donovan
authors.forename: David A
authors.initials: DA
authors.lastname: Collier
authors.forename: Thomas
authors.initials: T
authors.lastname: Werge
authors.forename: Dan
authors.initials: D
authors.lastname: Rujescu
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D033942:Adaptor Proteins, Vesicular Transport; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D012559:Schizophrenia / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C487178:AHI1 protein, human; D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport; D005819:Genetic Markers