Role of the transcription factor NFIC in odontoblast gene expression.
The transcription factor NFI-C is essential for root development. Mice lacking NFI-C develop abnormal roots and lose their teeth, resembling radicular dentin dysplasia I in humans. The purpose of this study was to understand the role of NFI-C in dentinogenesis. The authors found statistically significant increases in the expression of several mRNAs in cells lacking NFI-C, suggesting that these molecules might interfere with odontoblast cell migration and differentiation, and consequently with root development.
Kim
Mi Young
MY
University of Southern California, School of Dentistry, Los Angeles, USA.
Reyna
Julia
J
Chen
Li-Sha
LS
Zeichner-David
Maggie
M
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D002465:Cell Movement / Q000235:genetics; D003810:Dentinogenesis / Q000235:genetics*; D004195:Disease Models, Animal; D015870:Gene Expression / Q000235:genetics*; D051379:Mice; D051839:NFI Transcription Factors / Q000235:genetics*; D009804:Odontoblasts / Q000502:physiology*; D009805:Odontogenesis / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D014092:Tooth Root / Q000502:physiology
D051839:NFI Transcription Factors; C497648:Nfic protein, mouse; D012333:RNA, Messenger