The role of platelets in the pathogenesis of cerebral malaria.
Malaria is a major cause of morbidity and mortality in the developing world and cerebral malaria is responsible for the majority of malaria-associated deaths. There is a strong association between thrombocytopenia and outcome in malaria, suggesting a role for platelets in the pathogenesis of malaria. This thrombocytopenia is likely due to platelet activation possibly through an interaction between PfEMP1 on plasmodium and CD36 on platelets. Platelet activation by plasmodium has two potential consequences. It can lead to the formation of micro-aggregates of infected red blood cells and platelets which can occlude blood vessels and it also leads to binding to and activation of the endothelium.
Cox
Dermot
D
Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland. dcox@rcsi.ie
McConkey
Sam
S
D001792:Blood Platelets / Q000276:immunology* / Q000469:parasitology; D018955:CD36 Antigens / Q000276:immunology; D006801:Humans; D016779:Malaria, Cerebral / Q000150:complications / Q000276:immunology*; D010961:Plasmodium / Q000276:immunology*; D015539:Platelet Activation / Q000276:immunology; D015800:Protozoan Proteins / Q000276:immunology; D013921:Thrombocytopenia / Q000469:parasitology*
D018955:CD36 Antigens; D015800:Protozoan Proteins; C085731:erythrocyte membrane protein 1, Plasmodium falciparum