title: WebParc: a tool for analysis of the topography and volume of stroke from MRI.
abstract: The quantitative assessment of the anatomic consequences of cerebral infarction is critical in the study of the etiology and therapeutic response in patients with stroke. We present here an overview of the operation of "WebParc," a computational system that provides measures of stroke lesion volume and location with respect to canonical forebrain neural systems nomenclature. Using a web-based interface, clinical imaging data can be registered to a template brain that contains a comprehensive set of anatomic structures. Upon delineation of the lesion, we can express the size and localization of the lesion in terms of the regions that are intersected within the template. We demonstrate the application of the system using MRI-based diffusion-weighted imaging and document measures of the validity and reliability of its uses. Intra- and inter-rater reliability is demonstrated, and characterized relative to the various classes of anatomic regions that can be assessed. The WebParc system has been developed to meet criteria of both efficiency and intuitive operator use in the real time analysis of stroke anatomy, so as to be useful in support of clinical care and clinical research studies. This article is an overview of its base-line operation with quantitative anatomic characterization of lesion size and location in terms of stroke distribution within the separate gray and white matter compartments of the brain.
authors.affiliation: Center for Morphometric Analysis, Massachusetts General Hospital, 149 13th Street, Charlestown, Boston, MA, USA. David.Kennedy@umassmed.edu
authors.forename: David N
authors.initials: DN
authors.lastname: Kennedy
authors.forename: Christian
authors.initials: C
authors.lastname: Haselgrove
authors.forename: Nikos
authors.initials: N
authors.lastname: Makris
authors.forename: Donald M
authors.initials: DM
authors.lastname: Goldin
authors.forename: Michael H
authors.initials: MH
authors.lastname: Lev
authors.forename: David
authors.initials: D
authors.lastname: Caplan
authors.forename: Verne S
authors.initials: VS
authors.lastname: Caviness
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D020407:Internet; D008297:Male; D015588:Observer Variation; D011873:Radiology Information Systems; D015203:Reproducibility of Results; D020521:Stroke / Q000473:pathology*; D014584:User-Computer Interface