title: Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipids.
abstract: Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis. Our aim was to investigate serum levels of ZAG and polymorphisms in the ZAG gene in relation to serum lipids in man. Serum levels of ZAG correlated with serum levels of cholesterol (P = .00088) in healthy subjects and during weight loss (P = .059). The ZAG genotype was associated with total cholesterol (P = .014) and low-density lipoprotein cholesterol (P = .026) in healthy subjects, and the associations were replicated in an additional cohort (P = .0017 and P = .060, respectively). Our data indicate that ZAG plays a role in lipid metabolism.
authors.affiliation: The Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, 413 45 Gothenburg, Sweden.
authors.forename: Louise E
authors.initials: LE
authors.lastname: Olofsson
authors.forename: Bob
authors.initials: B
authors.lastname: Olsson
authors.forename: Theodore
authors.initials: T
authors.lastname: Lystig
authors.forename: Peter
authors.initials: P
authors.lastname: Jacobson
authors.forename: Margareta
authors.initials: M
authors.lastname: Jernås
authors.forename: Kajsa
authors.initials: K
authors.lastname: Sjöholm
authors.forename: Anders
authors.initials: A
authors.lastname: Gummesson
authors.forename: Lars
authors.initials: L
authors.lastname: Sjöström
authors.forename: Per
authors.initials: P
authors.lastname: Eriksson
authors.forename: Anders
authors.initials: A
authors.lastname: Hamsten
authors.forename: Laura P
authors.initials: LP
authors.lastname: Hale
authors.forename: Dag S
authors.initials: DS
authors.lastname: Thelle
authors.forename: Björn
authors.initials: B
authors.lastname: Carlsson
authors.forename: Lena M S
authors.initials: LM
authors.lastname: Carlsson
mesh_terms: D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007118:Immunoassay; D008055:Lipids / Q000097:blood*; D008297:Male; D011110:Polymorphism, Genetic; D029589:Seminal Plasma Proteins / Q000097:blood* / Q000235:genetics*; D000090203:Zn-Alpha-2-Glycoprotein
chemical_list: D008055:Lipids; D029589:Seminal Plasma Proteins; D000090203:Zn-Alpha-2-Glycoprotein