title: JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells.
abstract: The Drosophila midgut epithelium undergoes continuous regeneration that is sustained by multipotent intestinal stem cells (ISCs) underneath. Notch signaling has dual functions to control ISC behavior: it slows down the ISC proliferation and drives the activated ISCs into different differentiation pathways at a dose-dependent manner. Here we identified a molecular mechanism to unite these two contradictory functions. We found JAK-STAT signaling controls ISC proliferation and this ability is negatively regulated by Notch at least through a transcriptional control of the JAK-STAT signaling ligand, unpaired (upd). This study provides insight into how stem cells, under steady conditions, balance the processes of proliferation and differentiation to maintain the stable cellular composition of a healthy tissue.
authors.affiliation: The Mouse Cancer Genetics Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA. weiliu@mail.nih.gov
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Shree Ram
authors.initials: SR
authors.lastname: Singh
authors.forename: Steven X
authors.initials: SX
authors.lastname: Hou
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000166:cytology / Q000201:enzymology*; D007422:Intestines / Q000166:cytology*; D053612:Janus Kinases / Q000378:metabolism*; D051880:Receptors, Notch / Q000378:metabolism*; D050791:STAT Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology* / Q000201:enzymology; D014158:Transcription, Genetic
chemical_list: D029721:Drosophila Proteins; D051880:Receptors, Notch; D050791:STAT Transcription Factors; D053612:Janus Kinases