[Optimization of solubilizing process of Qingkailing injection based on GA-BPNN modeling].
OBJECTIVE
To optimize solubilizing process of Qingkailing injection.


METHODS
Uniform design experimental method and GA-BPNN modeling method were applied to optimize the technical parameters, and the solubility of cholic acid in medium was taken as optimizing index.


RESULTS
The type of solubilizer and pH of medium had greater impact on the index than the concentration for solubilizer. The optimum solubilizer was Tween-80. In a certain range the higher pH of medium was optimum; it was not necessary to use high-concentration solubilizer although there was positive correlation between the index and the concentration of solubilizer.


CONCLUSIONS
Uniform design combined with GA-BPNN modeling method is suitable for optimization of solubilizing process of Chinese materia medica injection, which has certain practical application value.
Liu
Ruixin
R
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. liuruixin7@yahoo.com.cn
Liu
Nancen
N
Shi
Xinyuan
X
Qiao
Yanjiang
Y
D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008419:Materia Medica / Q000737:chemistry*; D016571:Neural Networks, Computer; D012995:Solubility
D004365:Drugs, Chinese Herbal; D008419:Materia Medica; C504928:Qingkailing