A novel human adenovirus hexon protein of species D found in an AIDS patient.
To date, human adenoviruses are classified into 53 types (types 1-51 and types 53 and 54), which have been grouped into six species named A through F, and the recently identified type 52 has been proposed as member of a new species, G. Type classification is based on type-specific epitopes within loop 1 (L1) and loop 2 (L2) of the hexon protein, which contain seven hypervariable regions that are responsible for type specificity. In this paper, we present the characterization of an adenovirus strain isolated from a male AIDS patient in Cordoba, Argentina. This strain was found to be a member of species D by genomic Sma I restriction analysis. Sequencing of the L1 and L2 regions of the hexon gene and immunological characterization by virus neutralization revealed this hexon to be unique and distinct from the previously identified hexons of types within species D. A seroepidemiologic study in the human population of Cordoba showed that this strain was not endemic in the local human population.
Ferreyra
Leonardo
L
Virology Institute Dr. J. Vanella, School of Medical Sciences, National University of Cordoba, Cordoba, Argentina. ljferreyra@gmail.com
Giordano
Miguel
M
Martinez
Laura
L
Isa
M Beatriz
MB
Barril
Patricia
P
Masachessi
Gisela
G
Grutadauria
Sergio
S
Pavan
Jorge
J
Nates
Silvia
S
D017088:AIDS-Related Opportunistic Infections / Q000821:virology*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000821:virology; D000260:Adenoviruses, Human / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D000328:Adult; D036022:Capsid Proteins / Q000235:genetics* / Q000276:immunology; D002460:Cell Line; D005243:Feces / Q000821:virology; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny
D036022:Capsid Proteins; C018315:hexon capsid protein, Adenovirus