title: ATLANTIC DIP: the impact of obesity on pregnancy outcome in glucose-tolerant women.
abstract: OBJECTIVE A prospective study of the impact of obesity on pregnancy outcome in glucose-tolerant women. RESEARCH DESIGN AND METHODS The Irish Atlantic Diabetes in Pregnancy network advocates universal screening for gestational diabetes. Women with normoglycemia and a recorded booking BMI were included. Maternal and infant outcomes correlated with booking BMI are reported. RESULTS A total of 2,329 women fulfilled the criteria. Caesarean deliveries increased in overweight (OW) (odds ratio 1.57 [95% CI 1.24-1.98]) and obese (OB) (2.65 [2.03-3.46]) women. Hypertensive disorders increased in OW (2.30 [1.55-3.40]) and OB (3.29 [2.14-5.05]) women. Reported miscarriages increased in OB (1.4 [1.11-1.77]) women. Mean birth weight was 3.46 kg in normal BMI (NBMI), 3.54 kg in OW, and 3.62 kg in OB (P < 0.01) mothers. Macrosomia occurred in 15.5, 21.4, and 27.8% of babies of NBMI, OW, and OB mothers, respectively (P < 0.01). Shoulder dystocia occur in 4% (>4 kg) compared with 0.2% (<4 kg) babies (P < 0.01). Congenital malformation risk increased for OB (2.47 [1.09-5.60]) women. CONCLUSIONS OW and OB glucose-tolerant women have greater adverse pregnancy outcomes.
authors.affiliation: Department of Medicine, National University of Ireland, Galway, Ireland.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Owens
authors.forename: Eoin P
authors.initials: EP
authors.lastname: O'Sullivan
authors.forename: Breeda
authors.initials: B
authors.lastname: Kirwan
authors.forename: Gloria
authors.initials: G
authors.lastname: Avalos
authors.forename: Geraldine
authors.initials: G
authors.lastname: Gaffney
authors.forename: Fidelma
authors.initials: F
authors.lastname: Dunne
mesh_terms: D000328:Adult; D001267:Atlantic Ocean; D001786:Blood Glucose / Q000378:metabolism; D002585:Cesarean Section / Q000706:statistics & numerical data; D016640:Diabetes, Gestational / Q000097:blood / Q000453:epidemiology / Q000378:metabolism; D005260:Female; D005320:Fetal Macrosomia / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D007494:Ireland; D009765:Obesity / Q000097:blood / Q000150:complications / Q000453:epidemiology* / Q000378:metabolism; D010344:Patient Advocacy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000453:epidemiology* / Q000378:metabolism; D011256:Pregnancy Outcome / Q000453:epidemiology*
chemical_list: D001786:Blood Glucose