Real time three-dimensional echocardiographic assessment of left ventricular regional systolic function and dyssynchrony in patients with dilated cardiomyopathy.
OBJECTIVE
To evaluate left ventricular (LV) regional systolic function and dyssynchrony in patients with dilated cardiomyopathy (DCM) by real time three-dimensional echocardiography (RT-3DE).


METHODS
The study population comprised 30 normal controls (NOR) and 44 patients with DCM. We divided the left ventricle into apical, middle, and basal regions. We calculated the LV regional end-diastolic volume ((R)EDV), regional end-systolic volume ((R)ESV), regional ejection fraction ((R)EF), and standard deviation in the time to minimal systolic volume in each level segment (Tmsv-SD) of the three regions by RT-3DE.


RESULTS
Compared with NOR, the (R)EDV, (R)ESV, and Tmsv-SD of DCM were significantly higher, whereas the (R)EF was lower (P < 0.01). In DCM, the Tmsv-SD increased smoothly from base to apex, and the (R)EF gradually decreased from base to apex (P < 0. 05). Linear correlation was observed between the Tmsv-SD of the middle region and 3D-EF in DCM (r =-0. 6829, P < 0.01).


CONCLUSIONS
RT-3DE provides a simple and feasible approach to quantify LV regional systolic function and dyssynchrony.
Mu
Yuming
Y
Department of Echocardiography, First Affiliated Hospital, Xinjiang Medical University, Urmuqi 830000, China. yuming.mu@hotmail.com
Chen
Lu
L
Tang
Qi
Q
Ayoufu
Guligena
G
D002311:Cardiomyopathy, Dilated / Q000150:complications / Q000000981:diagnostic imaging*; D003199:Computer Systems; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging*; D016277:Ventricular Function, Left