The multiple mechanisms of T cell receptor cross-reactivity.
The ability of a single T cell to recognize the diverse peptides it encounters is based on T cell receptor crossreactivity. In this issue of Immunity, Macdonald et al. (2009) and Borbulevych et al. (2009) provide new insights into the structural principles underlying this fundamental property of T cells.
Yin
Yiyuan
Y
Center for Advanced Research in Biotechnology, WM Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA.
Mariuzza
Roy A
RA
D000818:Animals; D000941:Antigens / Q000276:immunology; D003429:Cross Reactions; D006649:Histocompatibility Antigens / Q000276:immunology*; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D006649:Histocompatibility Antigens; D011948:Receptors, Antigen, T-Cell