OXY-SCORE: a global index to improve evaluation of oxidative stress by combining pro- and antioxidant markers.
Our group recently proposed OXY-SCORE, a summary index of oxidative stress, computed by combining plasma free and total malondialdehyde (F- and T-MDA), glutathione in disulphide/reduced forms (GSSG/GSH), alpha- and gamma-tocopherol (TH), urine isoprostanes (iPF(2alpha)-III) levels, and plasma individual antioxidant capacity. Here, we describe the methods for the determination of the analytes and for the computation of the scores. We also report the results of two studies testing the performances of OXY-SCORE, and showing its value in assessing the oxidative status of cardiovascular patients and healthy subjects.
Veglia
Fabrizio
F
Unit of Biostatistics, Centro Cardiologico Monzino IRCCS, Milano, Italy. fabrizio.veglia@ccfm.it
Cavalca
Viviana
V
Tremoli
Elena
E
D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D005978:Glutathione / Q000097:blood; D019803:Glutathione Disulfide / Q000097:blood; D006801:Humans; D028421:Isoprostanes / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D015415:Biomarkers; D028421:Isoprostanes; D014810:Vitamin E; D008315:Malondialdehyde; D005978:Glutathione; D019803:Glutathione Disulfide