[Epidemiologic profile and prognostic factors in clinically localized prostate adenocarcinoma submitted to surgical treatment].
OBJECTIVE
Radical prostatectomy remains the standard treatment for early prostate cancer. This study was conducted to evaluate the outcome and prognostic factors of radical prostatectomy.


METHODS
A total of 500 patients with prostate cancer underwent radical prostatectomy at Santa Rita hospital- Maringa-PR, between 2000 and 2006. Clinical staging, preoperative prostate-specific antigen (PSA) and Gleason score were evaluated with pathological stage and margin status. Follow-up PSA monitoring and survival were analyzed.


RESULTS
Of 500 patients with clinical localized disease with a median follow up of 36,7 + or - 18,8 months. The average operative duration was 190 + or - 45 minutes and the average intra-operative bleeding was 630 ml. The patients' preoperative serum PSA was 7,8 + or - 4,5 ng/dl , with a higher proportion of Gleason Score < 6(72%) and The TNM stage pT2c (65%). For late postoperative complications: incontinence in 2% and 46 % with erectile dysfunction.


CONCLUSIONS
Radical prostatectomy in men shows excellent results. The chance of recurrence was directly associated with PSA = 10 ng/ml, high Gleason score and inversely proportional to age.
Nassif
Aissar Eduardo
AE
Doutorando do Programa de Pós-Graduação em Clínica Cirúrgica da Universidade Federal do Paraná e Professor Adjunto da Universidade Ingá (UNINGA), Maringá, PR, Brasil. aenassif@gmail.com
Tâmbara Filho
Renato
R
Paula
Regina Xavier Gomes de
RX
Taguchi
Willian Setsumi
WS
Pozzobon
Helio Jorge
HJ
D000230:Adenocarcinoma / Q000453:epidemiology* / Q000601:surgery*; D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000601:surgery*