Gastroprotective and antisecretory effects  of Ailanthus excelsa (Roxb).
Ailanthus excelsa (Roxb), an Egyptian medicinal species highly important for treating numerous diseases, was investigated against experimentally induced gastric ulcer in rodents. We evaluated the gastroprotective effect of four extracts (petroleum ether, diethyl ether, chloroform, and methanol) of A. excelsa bark by using the ethanol-induced gastric lesion model. The pretreatment of animals with methanolic, petroleum ether, and chloroformic extracts (100 mg/kg, oral (p.o.)) from A. excelsa significantly reduced gastric lesion induced by ulcerogenic agent (56, 47, and 70%, respectively) when compared with animals pretreated with vehicle. However, the diethyl ether pretreatment led to the least gastric lesion damage (83%), similar to the standard antiulcer drug, cimetidine, at the same dose (100 mg/kg, p.o.). The lower effective dose of diethyl ether extract, as well as cimetidine, given by intraduodenal route, significantly increased the pH values and reduced the acid output of gastric juice. Sterols, triterpenes,and quassinoids are present in the diethyl ether extract of A. excelsa stem bark, which presented the best gastroprotective action among the studied extracts. Our study confirmed the traditional indications of A. excelsa for the treatment of gastric ulcer.
Melanchauski
Larissa S
LS
São Paulo State University-UNESP, c.p. 610, Botucatu,SP CEP 18618-000, Brazil
Broto
Ana Paula G S
AP
Moraes
Thiago M
TM
Nasser
Ana Lúcia M
AL
Said
Ataa
A
Hawas
Usama W
UW
Rashed
Khaled
K
Vilegas
Wagner
W
Hiruma-Lima
Clélia A
CA
D032268:Ailanthus / Q000737:chemistry*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002927:Cimetidine / Q000494:pharmacology; D004195:Disease Models, Animal; D004534:Egypt; D000431:Ethanol / Q000633:toxicity; D005744:Gastric Acid / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology*; D012997:Solvents / Q000737:chemistry; D013276:Stomach Ulcer / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol; D002927:Cimetidine