Immune evasive mechanisms contributing to persistent Leishmania donovani infection.
The protozoan parasite Leishmania donovani, a causative agent of visceral leishmaniasis, has evolved several strategies to interfere with the immune system and establish persistent infections that are potentially lethal. In this article, we discuss two mechanisms of immune evasion adopted by the parasite: the induction of immune suppressive IL-10 responses and the generation of poor and functionally impaired CD8(+) T-cell responses.
Stäger
Simona
S
Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, BRB, Rm 655, Baltimore, MD 21205, USA. sstager1@jhmi.edu
Joshi
Trupti
T
Bankoti
Rashmi
R
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002908:Chronic Disease; D006801:Humans; D057131:Immune Evasion / Q000276:immunology*; D016753:Interleukin-10 / Q000276:immunology; D007893:Leishmania donovani / Q000472:pathogenicity*; D007898:Leishmaniasis, Visceral / Q000276:immunology* / Q000469:parasitology; D008213:Lymphocyte Activation; D051379:Mice
D016753:Interleukin-10