Dietary fat and early-onset prostate cancer risk.
The UK incidence of prostate cancer has been increasing in men aged < 60 years. Migrant studies and global and secular variation in incidence suggest that modifiable factors, including a high-fat diet, may contribute to prostate cancer risk. The aim of the present study was to investigate the role of dietary fat intake and its derivatives on early-onset prostate cancer risk. During 1999-2004, a population-based case-control study with 512 cases and 838 controls was conducted. Cases were diagnosed with prostate cancer when < or = 60 years. Controls were sourced from UK GP practice registers. A self-administered FFQ collected data on typical past diet. A nutritional database was used to calculate daily fat intake. A positive, statistically significant risk estimate for the highest v. lowest quintile of intake of total fat, SFA, MUFA and PUFA was observed when adjusted for confounding variables: OR 2.53 (95 % CI 1.72, 3.74), OR 2.49 (95 % CI 1.69, 3.66), OR 2.69 (95 % CI 1.82, 3.96) and OR 2.34 (95 % CI 1.59, 3.46), respectively, with all P for trend < 0.001. In conclusion, there was a positive statistically significant association between prostate cancer risk and energy-adjusted intake of total fat and fat subtypes. These results potentially identify a modifiable risk factor for early-onset prostate cancer.
Lophatananon
Artitaya
A
University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK. alopha2003@yahoo.co.uk
Archer
Jane
J
Easton
Douglas
D
Pocock
Richard
R
Dearnaley
David
D
Guy
Michelle
M
Kote-Jarai
Zsofia
Z
O'Brien
Lynne
L
Wilkinson
Rosemary A
RA
Hall
Amanda L
AL
Sawyer
Emma
E
Page
Elizabeth
E
Liu
Jo-Fen
JF
Barratt
Sandra
S
Rahman
Aneela A
AA
Eeles
Rosalind
R
Muir
Kenneth
K
D016022:Case-Control Studies; D004034:Diet Surveys; D004041:Dietary Fats / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity; D016017:Odds Ratio; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000209:etiology*; D006113:United Kingdom / Q000453:epidemiology
D004041:Dietary Fats