Pathogen recognition by the cell surface receptor CD46 induces autophagy.
Autophagy is a degradative mechanism involved in cell protection against invading pathogens. Although the autophagic process is well characterized, the molecular pathways leading to its activation upon pathogen binding remain poorly understood. Our recent work demonstrates that the cell surface pathogen receptor CD46 induces autophagy upon pathogen recognition. The molecular pathway linking CD46 to the autophagosome machinery relies on the scaffold protein GOPC and on the autophagosome formation complex Beclin 1/VPS34. The CD46-dependent autophagy is critical to an early control of infection.
Meiffren
Grégory
G
Université de Lyon, INSERM, U851, Université Lyon 1, IFR128, Lyon, France.
Joubert
Pierre-Emmanuel
PE
Grégoire
Isabel Pombo
IP
Codogno
Patrice
P
Rabourdin-Combe
Chantal
C
Faure
Mathias
M
D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism; D001343:Autophagy / Q000276:immunology*; D000071186:Beclin-1; D054884:Host-Pathogen Interactions; D051916:Membrane Cofactor Protein / Q000276:immunology*; D051379:Mice; D010588:Phagosomes / Q000378:metabolism
D051017:Apoptosis Regulatory Proteins; D000071186:Beclin-1; C115010:Becn1 protein, mouse; D051916:Membrane Cofactor Protein