Hybrid liposomes inhibit the growth of primary effusion lymphoma in vitro and in vivo.
Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) infection. It occurs predominantly in human immunodeficiency virus (HIV)-positive patients, is generally resistant to chemotherapy, and has a poor prognosis. Hybrid liposomes (HL), composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene dodecyl ether, inhibited PEL cell proliferation and induced apoptosis in vitro. Intraperitoneal inoculation of the BCBL-1 PEL cell line into NOD/Scid/Jak3 deficient mice induced massive ascites, which were inhibited by HL21 without significant systemic toxicity in the mice. These results suggest that HL21 is an effective and attractive reagent for PEL treatment.
Towata
Tomomi
T
Division of Applied Life Science, Graduate School of Engineering, Sojo University, Kumamoto, Japan.
Komizu
Yuji
Y
Suzu
Shinya
S
Matsumoto
Yoko
Y
Ueoka
Ryuichi
R
Okada
Seiji
S
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001201:Ascites / Q000188:drug therapy; D002455:Cell Division / Q000187:drug effects; D004134:Dimyristoylphosphatidylcholine; D006801:Humans; D053616:Janus Kinase 3 / Q000172:deficiency; D008081:Liposomes / Q000737:chemistry / Q000627:therapeutic use*; D054685:Lymphoma, Primary Effusion / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D016688:Mice, Inbred NOD; D018345:Mice, Knockout; D016513:Mice, SCID; D011092:Polyethylene Glycols; D014407:Tumor Cells, Cultured / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
D008081:Liposomes; C478747:polyoxyethylene-10-dodecyl ether; D011092:Polyethylene Glycols; C507935:Jak3 protein, mouse; D053616:Janus Kinase 3; D004134:Dimyristoylphosphatidylcholine