title: Powering reprogramming with vitamin C.
abstract: In this issue of Cell Stem Cell, Esteban et al. (2009) report that vitamin C enhances the reprogramming efficiency of mouse and human fibroblasts transduced with three (Oct4/Klf4/Sox2) or four (Oct4/Klf4/Sox2/cMyc) factors. Vitamin C can alleviate cell senescence by p53 repression and may accelerate reprogramming by synergizing with epigenetic regulators.
authors.affiliation: Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen 518055, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.forename: Hongkui
authors.initials: H
authors.lastname: Deng