Amisulpride improved debilitating clozapine-induced sialorrhea.
Clozapine induced sialorrhea is a common and troublesome adverse effect leading to poor treatment compliance. Although there are various treatment options, none has been demonstrated to be superior. In our case study, amisulpride 150 mg/d significantly reduced troublesome daytime sialorrhea along with minimal improvement in nocturnal sialorrhea.
Praharaj
Samir Kumar
SK
Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India. samirpsyche@yahoo.co.in
Ray
Prasenjit
P
Gandotra
Sachin
S
D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012798:Sialorrhea / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy*; D013469:Sulpiride / Q000031:analogs & derivatives / Q000627:therapeutic use*
D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D013469:Sulpiride; D003024:Clozapine