Further diffusion tensor imaging contribution in horizontal gaze palsy and progressive scoliosis.
In two siblings with clinical diagnosis of horizontal gaze palsy associated with progressive scoliosis (HGPPS) we could demonstrate by diffusion tensor imaging: (1) An anterior displacement of the transverse pontine fibers; (2) Posterior clumping of the corticospinal, medial lemniscus and central tegmental tracts and of the medial and dorsal longitudinal fasciculi complex; (3) Absent decussation of superior cerebellar peduncle. Those findings can contribute as surrogate markers for the diagnosis.
Otaduy
Maria Conceptión García
MC
Department of Radiology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Leite
Claudia da Costa
Cda C
Nagae
Lídia Mayumi
LM
Pinho
Marco da Cunha
Mda C
Bueno
Clarissa
C
Reed
Umbertina Conti
UC
Kok
Fernando
F
D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D015835:Ocular Motility Disorders / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D011149:Pons / Q000473:pathology; D012600:Scoliosis / Q000150:complications / Q000175:diagnosis*