title: [IgE deficiency: a forgotten disease?].
abstract: BACKGROUND
  Selective IgE deficiency is a profound deficiency (< 5 UI/mL) or absence of serum IgE levels without other immunologic abnormalities. It is usually asymptomatic, but may be associated with recurrent respiratory infections, chronic fatigue, and musculoskeletal complaints.
  
  
  OBJECTIVE
  To describe the evolution and treatment in patients with selective IgE deficiency.
  
  
  METHODS
  In selective IgE's deficiency patients identification note, atopy history, concurrent diseases, clinic of allergic diseases, Prick test and prior response to treatment were analyzed.
  
  
  RESULTS
  Eleven patients were included, five women and six men within 16 months to 10 years old. The patients had serum IgE levels < 5 UI with other immunoglobulins and sub-classes in normal levels; except a patient with concomitant IgA and IgE deficiency. The treatment administered was since prophylactic antibiotic to intravenous gammaglobulin.
  
  
  CONCLUSIONS
  We established the diagnosis of selective IgE deficiency in patient with serum IgE levels < 5 UI/mL associated with recurrent respiratory infections.
  
  
  CONCLUSIONS
  We need more clinic studies to document with precision the selective IgE deficiency.
authors.affiliation: Servicio de Alergia e Inmunología, quinto piso, Hospital Regional Lic. Adolfo López Mateos. Universidad 1321, colonia Florida, 01030 México, DF. sus_gar_pav@yahoo.com.mx
authors.forename: Susana
authors.initials: S
authors.lastname: García Pavón Osorio
authors.forename: José Jesús
authors.initials: JJ
authors.lastname: López Tiro
authors.forename: Javier
authors.initials: J
authors.lastname: Gómez Vera
mesh_terms: D019072:Antibiotic Prophylaxis; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004198:Disease Susceptibility; D004406:Dysgammaglobulinemia / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D006801:Humans; D017098:IgA Deficiency / Q000453:epidemiology; D016867:Immunocompromised Host; D007073:Immunoglobulin E / Q000172:deficiency*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D008800:Mexico / Q000453:epidemiology; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control
chemical_list: D016756:Immunoglobulins, Intravenous; D007073:Immunoglobulin E