title: Is the action spectrum for the UV-induced production of previtamin D3 in human skin correct?
abstract: The universally recognised action spectrum for the UV-induced conversion of 7-dehydrocholesterol to previtamin D(3) in human skin was published in 1982, and indicates a maximum at about 297 nm with essentially no production above 315 nm. This work represents a milestone in research on vitamin D, but limitations in the original data should be recognised. Various findings have arisen in recent years which cast doubts on the accuracy of the action spectrum and its application for spectral weighting in calculations of effective UV doses. In conclusion, the construction of an entirely new computational model to predict previtamin D levels is recommended.
authors.affiliation: Biomedical Sciences, University of Edinburgh Medical School, Teviot Place, Edinburgh, EH8 9AG, UK. M.Norval@ed.ac.uk
authors.forename: Mary
authors.initials: M
authors.lastname: Norval
authors.forename: Lars Olof
authors.initials: LO
authors.lastname: Björn
authors.forename: Frank R
authors.initials: FR
authors.lastname: de Gruijl
mesh_terms: D002762:Cholecalciferol / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000378:metabolism; D003684:Dehydrocholesterols / Q000378:metabolism; D006801:Humans; D012867:Skin / Q000378:metabolism* / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: D003684:Dehydrocholesterols; D002762:Cholecalciferol; C016705:7-dehydrocholesterol; C025168:previtamin D(3)