Chromatin 'programming' by sequence--is there more to the nucleosome code than %GC?
The role of genomic sequence in directing the packaging of eukaryotic genomes into chromatin has been the subject of considerable recent debate. A new paper from Tillo and Hughes shows that the intrinsic thermodynamic preference of a given sequence in the yeast genome for the histone octamer can largely be captured with a simple model, and in fact is mostly explained by %GC. Thus, the rules for predicting nucleosome occupancy from genomic sequence are much less complicated than has been claimed. See research article http://www.biomedcentral.com/1471-2105/10/442.
Hughes
Amanda
A
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street No, 903, Worcester, MA 01605, USA.
Rando
Oliver J
OJ
D000818:Animals; D001482:Base Composition / Q000235:genetics; D001483:Base Sequence / Q000235:genetics; D002843:Chromatin / Q000235:genetics*; D019295:Computational Biology / Q000379:methods; D018899:CpG Islands / Q000235:genetics; D003597:Cytosine Nucleotides / Q000235:genetics; D006150:Guanine Nucleotides / Q000235:genetics; D006801:Humans; D009707:Nucleosomes / Q000235:genetics*; D011237:Predictive Value of Tests
D002843:Chromatin; D003597:Cytosine Nucleotides; D006150:Guanine Nucleotides; D009707:Nucleosomes