Toward the development of a sensitive, pre-clinical screen for neurological diseases from spontaneous neural coordination in juvenile and young-adult C57BK6 mice.
Spontaneous Frequency Bursts (SFBs) are a newly discovered form of long-distance neural coordination. They have several distinctive properties, including near-simultaneity of occurrence (+/-25-50 ms) across distant brain regions and high within- and across-site coherence in multiple low and high frequency bands, presumably requiring high axonal, dendritic and vascular integrity. We examined whether SFBs occurred in young and young-adult C57BK6 mice with properties similar to those seen in rats. We found that across the entorhinal and piriform cortices, SFBs occur robustly in young and young-adult mice under light anesthesia, and that their rate of occurrence dropped sharply as anesthetic levels increased, as in rats. Moreover, murine SFBs showed high cross-site coherence in multiple frequency bands, including those that require exquisite action potential timing to be maintained across long distances. We discuss our findings in light of SFBs potential as a pre-clinical biomarker for diseases affecting action potential firing and local field potential coherence, especially in high frequency ranges (20-30 Hz and beyond).
Robson
Jordan
J
Behavioral Neuroscience Program, Department of Psychology, University of Florida, Gainesville, FL 32611, USA.
Mehta
Nisarg
N
Polcz
Jeanette E
JE
Hermer
Linda
L
D000200:Action Potentials; D000375:Aging / Q000502:physiology*; D000758:Anesthesia; D000818:Animals; D001921:Brain / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009422:Nervous System Diseases / Q000503:physiopathology*