Galactosylated cucurbituril-inclusion polyplex for hepatocyte-targeted gene delivery.
The work demonstrates a judicious approach to achieve hepatocyte cell-targeted highly efficient gene delivery by utilizing a supramolecular complex of galactosylated cucurbituril and dextran-spermine conjugates.
Kim
Soo Kyung
SK
Department of Chemistry, BK21 Program, Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea.
Park
Kyeng Min
KM
Singha
Kaushik
K
Kim
Jeeyeon
J
Ahn
Youngjoo
Y
Kim
Kimoon
K
Kim
Won Jong
WJ
D003911:Dextrans / Q000737:chemistry / Q000378:metabolism; D016503:Drug Delivery Systems; D005690:Galactose / Q000737:chemistry / Q000378:metabolism*; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D022781:Hepatocytes / Q000737:chemistry / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000378:metabolism*; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D013096:Spermine / Q000737:chemistry / Q000378:metabolism; D000099246:Cucurbit(n)urils
D003911:Dextrans; D005690:Galactose; D047028:Macrocyclic Compounds; D046911:Macromolecular Substances; D013096:Spermine; D000099246:Cucurbit(n)urils