MicroTUB(B3)ules and brain development.
The microtubule network is crucial for the developing nervous system, and mutations in tubulin-encoding genes disrupt neuronal migration. Tischfield et al. (2010) now report that mutations in the tubulin-encoding gene TUBB3 have a striking impact on microtubule dynamics in neurons, resulting in a diverse set of disease symptoms.
Singh
Karun K
KK
Howard Hughes Medical Institute, Cambridge, MA 02139, USA.
Tsai
Li-Huei
LH
D000818:Animals; D001921:Brain / Q000196:embryology* / Q000378:metabolism; D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D009154:Mutation; D055495:Neurogenesis; D014404:Tubulin / Q000235:genetics / Q000378:metabolism*
C498585:TUBB3 protein, human; D014404:Tubulin