Two new cytotoxic disulfated holostane glycosides from the sea cucumber Pentacta quadrangularis.
Two new disulfated triterpene glycosides, pentactasides B and C (1 and 2, resp.), were isolated from the sea cucumber Pentacta quadrangularis collected from the South China Sea. Their structures were elucidated by extensive spectral analysis (2D-NMR and MS) and chemical methods. The compounds 1 and 2 possess the same tetrasaccharide moieties with two sulfated groups, but are different in the side chains of the triterpene aglycone. Pentactasides B and C (1 and 2, resp.) showed significant cytotoxicities (IC(50) 0.09-2.30 microM) against different human tumor cell lines.
Han
Hua
H
College of Animal Sciences, Zhejiang University, 268 Kai-Xuan Road, Hangzhou 310029, P R China.
Xu
Qiang-Zhi
QZ
Yi
Yang-Hua
YH
Gong
Wei
W
Jiao
Bing-Hua
BH
D000818:Animals; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D012616:Sea Cucumbers / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
C548430:16-(acetyloxy)-18-oxo-18,20-epoxylanosta-7,24-dien-3-yl 3-O-methylglucopyranosyl-(1-3)-xylopyranosyl-(1-4)-6-deoxy-2-O-sulfonatoglucopyranosyl-(1-2)-4-O-sulfonatoxylopyranoside; C548431:16-(acetyloxy)-18-oxo-18,20-epoxylanosta-7,25-dien-3-yl 3-O-methylglucopyranosyl-(1-3)-xylopyranosyl-(1-4)-6-deoxy-2-O-sulfonatoglucopyranosyl-(1-2)-4-O-sulfonatoxylopyranoside; D006027:Glycosides; D012503:Saponins; D014315:Triterpenes