Growing teratoma syndrome of the ovary after fertility-sparing surgery and successful pregnancy.
BACKGROUND
Growing teratoma syndrome (GTS) is rare and is defined as an enlarging mature teratoma that arises during or after chemotherapy for a malignant germ cell tumor, with normalization of previously elevated serum tumor markers.


METHODS
A 30-year-old nulliparous Japanese woman was diagnosed as having a stage IIIa immature teratoma. After fertility-sparing surgery, she received 4 cycles of chemotherapy consisting of cisplatin, etoposide and bleomycin. Thereafter, she successfully gave birth twice. Eight years after the initial surgery, a mass mimicking an adrenal tumor was resected laparoscopically. Surgical specimens revealed a mature teratoma, and she was diagnosed as having GTS postoperatively.


CONCLUSIONS
Clinicians should consider that GTS may present late, even after pregnancy. Therefore, long-term follow-up of patients treated for ovarian immature teratoma should be mandatory.
Matsushita
Hiroshi
H
Departments of Obstetrics and Gynecology, Tsuruoka Municipal Shonai Hospital, Tsuruoka-City, Japan.
Arai
Kei
K
Fukase
Masayuki
M
Takayanagi
Takeshi
T
Ikarashi
Hirokazu
H
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D014408:Biomarkers, Tumor / Q000097:blood; D001761:Bleomycin / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis / Q000175:diagnosis* / Q000628:therapy; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D011247:Pregnancy; D013724:Teratoma / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery
D014408:Biomarkers, Tumor; D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin