The role of facial sebum secretion in acne pathogenesis: facts and controversies.
Increased sebum secretion has been known as one of the major pathogenic factors in the development of acne; however, objective sebum measurement methods have been developed only recently. We have limited information about the association of sebum secretion, and the development of acne. There continues to be controversy about the role of sebum in the development of acne. This contribution will discuss sebum measurement techniques and the results of recent studies on the relationship of sebum, facial cosmetic skin type, and acne. New therapeutic modalities for inflammatory acne aim to control seborrhea. Superficial chemical peels, laser treatment for inflammatory acne, and photodynamic therapy are used as adjunctive therapies for acne; however, their sebosuppressive effects are only temporary.
Youn
Sang Woong
SW
Department of Dermatology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 166 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi 463-707, South Korea. swyoun@snu.ac.kr
D000152:Acne Vulgaris / Q000453:epidemiology / Q000382:microbiology* / Q000503:physiopathology / Q000628:therapy; D015982:Bias; D019317:Evidence-Based Medicine; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology / Q000382:microbiology* / Q000503:physiopathology; D006801:Humans; D011425:Propionibacterium acnes / Q000472:pathogenicity*; D012307:Risk Factors; D012627:Sebaceous Glands / Q000378:metabolism* / Q000382:microbiology; D012629:Sebum / Q000378:metabolism*