title: Mechanical property characterization of bilayered tablets using nondestructive air-coupled acoustics.
abstract: A noncontact/nondestructive air-coupled acoustic technique to be potentially used in mechanical property determination of bilayer tablets is presented. In the reported experiments, a bilayer tablet is vibrated via an acoustic field of an air-coupled transducer in a frequency range sufficiently high to excite several vibrational modes (harmonics) of the tablet. The tablet vibrational transient responses at a number of measurement points on the tablet are acquired by a laser vibrometer in a noncontact manner. An iterative computational procedure based on the finite element method is utilized to extract the Young's modulus, the Poisson's ratio, and the mass density values of each layer material of a bilayer tablet from a subset of the measured resonance frequencies. For verification purposes, a contact ultrasonic technique based on the time-of-flight data of the longitudinal (pressure) and transverse (shear) acoustic waves in each layer of a bilayer tablet is also utilized. The extracted mechanical properties from the air-coupled acoustic data agree well with those determined from the contact ultrasonic measurements. The mechanical properties of solid oral dosage forms have been shown to impact its mechanical integrity, disintegration profile and the release rate of the drug in the digestive tract, thus potentially affecting its therapeutic response. The presented nondestructive technique provides greater insight into the mechanical properties of the bilayer tablets and has the potential to identify quality and performance problems related to the mechanical properties of the bilayer tablets early on the production process and, consequently, reduce associated cost and material waste.
authors.affiliation: Department of Mechanical and Aeronautical Engineering, Photo-Acoustic Research Laboratory, Clarkson University, Potsdam, New York 13699-5725, USA.
authors.forename: Ilgaz
authors.initials: I
authors.lastname: Akseli
authors.forename: Dipankar
authors.initials: D
authors.lastname: Dey
authors.forename: Cetin
authors.initials: C
authors.lastname: Cetinkaya
mesh_terms: D000162:Acoustics; D000388:Air; D004304:Dosage Forms; D005079:Excipients; D007834:Lasers; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011312:Pressure; D013607:Tablets / Q000737:chemistry*; D014465:Ultrasonics; D014732:Vibration
chemical_list: D004304:Dosage Forms; D005079:Excipients; D004364:Pharmaceutical Preparations; D013607:Tablets