Annual electrocardiograms consistent with silent progression of cardiac involvement in sporadic familial amyloid polyneuropathy: a case report.
Understanding the clinical characteristics of transthyretin familial amyloid polyneuropathy (TTR-FAP) is critical for early diagnosis and timely referral for liver transplantation. Here, we describe a 52-year-old man who had slight paresthesia for four years and whose final diagnosis of TTR-cardiac amyloidosis caused by sporadic FAP was delayed despite annual electrocardiography. Curative liver transplantation was postponed because of progressive cardiac involvement. This experience highlights the difficulties associated with diagnosing TTR-FAP, especially when it is sporadic, and underscores the importance of slight changes in ECG that could indicate FAP.
Takigawa
Masateru
M
Cardiovascular Center, Department of Internal Medicine, Japanese Red Cross Society, Nagoya Daini Hospital, Nagoya. teru.takigawa@gmail.com
Hashimura
Kazuhiko
K
Ishibashi-Ueda
Hatsue
H
Yamada
Naoaki
N
Kiso
Keisuke
K
Nanasato
Mamoru
M
Yoshida
Yukihiko
Y
Hirayama
Haruo
H
D028227:Amyloid Neuropathies, Familial / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D028226:Amyloidosis, Familial / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D018450:Disease Progression; D004562:Electrocardiography / Q000639:trends*; D006331:Heart Diseases / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged