Particle shape: a new design parameter for passive targeting in splenotropic drug delivery.
The role of particle size and surface modification on biodistribution of nanocarriers is widely reported. We report for the first time the role of nanoparticle shape on biodistribution. Our study demonstrates that irregular shaped polymer lipid nanoparticles (LIPOMER) evade kupffer cells and localize in the spleen. We also demonstrate the macrophage-evading characteristic of the irregular-shaped LIPOMER. Our results suggest particle shape as an important tool for passive targeting of nanocarriers in splenotropic drug delivery.
Devarajan
Padma V
PV
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P. Marg, Matunga (E), Mumbai 400019, Maharashtra, India. pvdevarajan@gmail.com
Jindal
Anil B
AB
Patil
Rajesh R
RR
Mulla
Fernaz
F
Gaikwad
Rajiv V
RV
Samad
Abdul
A
D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008264:Macrophages / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D020849:Raloxifene Hydrochloride; D014018:Tissue Distribution
D008055:Lipids; D011108:Polymers; D020849:Raloxifene Hydrochloride