title: Glycoxidative stress-induced damage on lipid profile in a fructose-enriched diet model of insulin resistance in rats.
abstract: OBJECTIVE
  To study alterations in plasma lipid profile and oxidative damage to lipoprotein fractions (LF) and their fatty acids during an early insulin-resistant and increased oxidative state developed by a fructose-rich diet (FRD).
  
  
  RESULTS
  Wistar rats were fed a commercial diet with (FRD) or without (CD) 10% fructose in the drinking water. After 3 weeks, plasma glucose, triglyceride (TG), insulin (I), fructosamine (F), free fatty acids (FFA) and lipid profile (total cholesterol [TC] and HDL-C, LDL-C and VLDL-C sub-fractions) were determined. The insulin sensitivity HOMA index was assessed. FRD-fed rats had higher plasma TG, I, and F levels; increased HOMA; decreased HDL-C and LDL-C; augmented VLDL-C and TC/HDL-C, and TG/HDL-C atherogenic risk scores. LF of FRD rats had increased oxidative damage on the fatty acyl profile and in copper-induced lipoperoxidation.
  
  
  CONCLUSIONS
  Fructose feeding early increases the atherogenic risk inducing an insulin resistant-glycoxidative state that affects plasma lipid profiles.
authors.affiliation: Centro de Endocrinología Experimental y Aplicada, UNLP-CONICET La Plata, PAHO/WHO Collaborating Center, Argentina.
authors.forename: M E
authors.initials: ME
authors.lastname: García
authors.forename: C A
authors.initials: CA
authors.lastname: Marra
authors.forename: O R
authors.initials: OR
authors.lastname: Rebolledo
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019422:Dietary Sucrose / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood*; D005632:Fructose / Q000008:administration & dosage / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019422:Dietary Sucrose; D005227:Fatty Acids; D008055:Lipids; D008074:Lipoproteins; D005632:Fructose