title: Unexpected domino reaction via Pd-catalyzed Sonogashira coupling of benzimidoyl chlorides with 1,6-enynes and cyclization to synthesize quinoline derivatives.
abstract: A domino reaction via palladium-catalyzed Sonogashira coupling of benzimidoyl chlorides with 1,6-enynes and then cyclization to form quinoline derivatives has been developed. The reaction conditions and the scope of the process are examined, and a plausible mechanism is proposed. The procedure is simple, rapid, and general, and the substrates are readily available.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
authors.forename: Guo-Lin
authors.initials: GL
authors.lastname: Gao
authors.forename: Yan-Ning
authors.initials: YN
authors.lastname: Niu
authors.forename: Ze-Yi
authors.initials: ZY
authors.lastname: Yan
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Wang
authors.forename: Gang-Wei
authors.initials: GW
authors.lastname: Wang
authors.forename: Ali
authors.initials: A
authors.lastname: Shaukat
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000480:Alkynes; D001549:Benzamides; D011804:Quinolines; D010165:Palladium; C037219:quinoline