Catechol-O-methyltransferase val108/158met genotype, major depressive disorder and response to selective serotonin reuptake inhibitors in major depressive disorder.
The functional val108/158met polymorphism of the COMT gene (rs4680) was evaluated in major depressive disorder (MDD), and in the treatment response to antidepressants in MDD. We could not demonstrate any significant difference in the distribution of this COMT single-nucleotide polymorphism (SNP) in the treatment response to selective serotonin reuptake inhibitors or between patients with MDD and control subjects.
Illi
Ari
A
University of Tampere, Medical School, Tampere, Finland. ari.illi@uta.fi
Setälä-Soikkeli
Eija
E
Kampman
Olli
O
Viikki
Merja
M
Nuolivirta
Timo
T
Poutanen
Outi
O
Huhtala
Heini
H
Mononen
Nina
N
Lehtimäki
Terho
T
Leinonen
Esa
E
D002394:Catechol O-Methyltransferase / Q000235:genetics*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics*; D005387:Finland; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008715:Methionine / Q000235:genetics*; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D014633:Valine / Q000235:genetics*
D002394:Catechol O-Methyltransferase; D008715:Methionine; D017367:Selective Serotonin Reuptake Inhibitors; D014633:Valine