title: Nephrotic syndrome and Guillan-Barré Syndrome: a rare association in child.
abstract: Only few cases of nephrotic syndrome associated with Guillain-Barre Syndrome (GBS) have been reported in the adult and pediatric literature. A 3-year-old boy was initially admitted to our hospital following five days of progressive weakness of his extremities, fatigue, right leg pain and numbness. There was no past history of renal or neurological disease. Cerebro-spinal fluid studies showed a protein level of 92 mg/dL and a white cell count of 1 per high-power field. The diagnosis of GBS was verified with a nerve conduction velocity test as well as. The GBS symptoms improved gradually on intravenous immunoglobulin. Three weeks later, he developed severe proteinuria and edema; laboratory investigation showed nephrotic syndrome which responded to steroid therapy. Renal biopsy showed minimal change glomerulonephritis. He remained free of proteinuria during his 20 months of follow-up.
authors.affiliation: Pediatric's Department, Children's Hospital of Tunis, Tunisia. olfa.bouyahia@rns.tn
authors.forename: Olfa
authors.initials: O
authors.lastname: Bouyahia
authors.forename: Ibtissem
authors.initials: I
authors.lastname: Khelifi
authors.forename: Lamia
authors.initials: L
authors.lastname: Gharsallah
authors.forename: Kais
authors.initials: K
authors.lastname: Harzallah
authors.forename: Sonia Mazigh
authors.initials: SM
authors.lastname: Mrad
authors.forename: Tahar
authors.initials: T
authors.lastname: Ghargah
authors.forename: Samir
authors.initials: S
authors.lastname: Boukthir
authors.forename: Sammoud El Gharbi
authors.initials: Sel G
authors.lastname: Azza
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002675:Child, Preschool; D005221:Fatigue / Q000209:etiology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D006987:Hypesthesia / Q000209:etiology; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007866:Leg; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D009460:Neurologic Examination; D010146:Pain / Q000209:etiology; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous; D013256:Steroids