title: Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1.
abstract: The cJun N-terminal kinase 1 (JNK1) is implicated in diet-induced obesity. Indeed, germline ablation of the murine Jnk1 gene prevents diet-induced obesity. Here we demonstrate that selective deficiency of JNK1 in the murine nervous system is sufficient to suppress diet-induced obesity. The failure to increase body mass is mediated, in part, by increased energy expenditure that is associated with activation of the hypothalamic-pituitary-thyroid axis. Disruption of thyroid hormone function prevents the effects of nervous system JNK1 deficiency on body mass. These data demonstrate that the hypothalamic-pituitary-thyroid axis represents an important target of metabolic signaling by JNK1.
authors.affiliation: Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Sabio
authors.forename: Julie
authors.initials: J
authors.lastname: Cavanagh-Kyros
authors.forename: Tamera
authors.initials: T
authors.lastname: Barrett
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Jung
authors.forename: Hwi Jin
authors.initials: HJ
authors.lastname: Ko
authors.forename: Helena
authors.initials: H
authors.lastname: Ong
authors.forename: Caroline
authors.initials: C
authors.lastname: Morel
authors.forename: Alfonso
authors.initials: A
authors.lastname: Mora
authors.forename: Judith
authors.initials: J
authors.lastname: Reilly
authors.forename: Jason K
authors.initials: JK
authors.lastname: Kim
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Davis
mesh_terms: D000818:Animals; D004435:Eating; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D048055:Mitogen-Activated Protein Kinase 8 / Q000235:genetics / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism*; D015398:Signal Transduction; D013961:Thyroid Gland / Q000378:metabolism*
chemical_list: D007328:Insulin; D048055:Mitogen-Activated Protein Kinase 8