title: Cardiac resynchronisation therapy: what a hospital practitioner needs to know?
abstract: The incidence and prevalence of heart failure are rapidly rising. Despite the improvement in pharmacologic treatment, many patients have severe persistent symptoms, and their prognosis remains poor. One of the most recent advances in heart failure management is the concept of cardiac resynchronisation therapy (CRT). This therapy aims to pace the right and left ventricles synchronously to contract simultaneously and therefore enhances cardiac output. Clinical trials on CRT have demonstrated both morbidity and mortality benefits. This article reviews the evidence for CRT, the current indications, and important information relevant to the clinician treating patients with heart failure. It also highlights some of the current controversies in this field as well as the need for future research.
authors.affiliation: Liverpool Heart and Chest Hospital, Thomas Drive, Liverpool, UK. albouaini@gmail.com
authors.forename: Khaled
authors.initials: K
authors.lastname: Albouaini
authors.forename: Amr
authors.initials: A
authors.lastname: Alkarmi
authors.forename: David Justin
authors.initials: DJ
authors.lastname: Wright
mesh_terms: D002302:Cardiac Output; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D015337:Multicenter Studies as Topic; D010138:Pacemaker, Artificial; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic