[Effect of moxibustion in treating knee joint osteoarthritis and its relation with contents of hyaluronic acid in serum and synovial fluid].
OBJECTIVE
To investigate the clinical effects of moxibustion (Mox) in treating knee joint osteoarthritis, and to detect the change of hyaluronic acid (HA) level in serum and synovial fluid (SF) for evaluating its significance.


METHODS
Thirty OA patients were treated with Mox applied on inner and outer hsiyens and Ashi point for 10 min once a day, 5 times a week for 3 months and the therapeutic efficacy was evaluated. Serum and SF levels of HA were measured by radio-immunoassay before and after the 3-month treatment, and compared with those from 30 non-OA persons for normal control.


RESULTS
After treatment, 19 patients (20 joints) out of the 30 patients were cured, the efficacy of Mox was evaluated as markedly effective in 8 patients on 10 joints, and as effective in 3 patients on 4 joints, the cure rate being 63.3%. Before treatment, HA level in serum (122.87 +/- 34.10 microg/L) was higher and in SF (0.98 +/- 0.17 g/L) was lower in OA patients than those in the normal controls (68.32 +/- 21.48 microg/L and 1.62 +/- 0.30 g/L, P<0.01), whereas after treatment, both the serum and SF levels of HA in patients changed toward normal range (70.29 +/- 27.30 microg/L and 1.58 +/- 0.26 g/L), showing insignificant difference as compared with those in the controls (P<0.01).


CONCLUSIONS
Mox is an effective approach for treatment of OA, and the levels of HA in serum and SF can be taken as the quantitative indicators for evaluating the pathogenetic condition of OA patients.
Li
Zhuo-Dong
ZD
Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, China. lzdmark@yahoo.com.cn
Cao
Lie-Hu
LH
Wang
Si-Cheng
SC
D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis* / Q000097:blood; D008297:Male; D008875:Middle Aged; D009071:Moxibustion; D020370:Osteoarthritis, Knee / Q000097:blood / Q000378:metabolism / Q000628:therapy*; D013582:Synovial Fluid / Q000378:metabolism*
D006820:Hyaluronic Acid