title: Determinants of specificity at the protein-lipid interface in membranes.
abstract: The complexity of pro- and eukaryotic lipidomes is increasingly appreciated mainly owing to the advance of mass spectrometric methods. Biophysical approaches have revealed that the large number of lipid classes and molecular species detected have implications for the self-organizing potential of biological membranes, resulting in the formation of lateral heterogeneous phases. How membrane proteins are able to adapt specifically to their surrounding heterogeneous matrix, and whether this environment affects protein targeting and function, is therefore a matter of particular interest. Here, we review specific protein-lipid interactions, focusing on the molecular mechanisms that determine specificity at the protein-lipid interface, and on membrane proteins that require lipids as cofactors for their architecture and function.
authors.affiliation: Heidelberg University, Biochemistry Center, Heidelberg, Germany. felix.wieland@bzh.uni-heidelberg.de \
authors.forename: Andreas M
authors.initials: AM
authors.lastname: Ernst
authors.forename: F Xabier
authors.initials: FX
authors.lastname: Contreras
authors.forename: Britta
authors.initials: B
authors.lastname: Brügger
authors.forename: Felix
authors.initials: F
authors.lastname: Wieland
mesh_terms: D000818:Animals; D050556:Fatty Acid-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D050356:Lipid Metabolism / Q000502:physiology; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism*; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D008566:Membranes / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D011485:Protein Binding; D013379:Substrate Specificity; D013499:Surface Properties
chemical_list: D050556:Fatty Acid-Binding Proteins; D008563:Membrane Lipids; D008565:Membrane Proteins