title: Catechol-O-methyltransferase val108/158met genotype, major depressive disorder and response to selective serotonin reuptake inhibitors in major depressive disorder.
abstract: The functional val108/158met polymorphism of the COMT gene (rs4680) was evaluated in major depressive disorder (MDD), and in the treatment response to antidepressants in MDD. We could not demonstrate any significant difference in the distribution of this COMT single-nucleotide polymorphism (SNP) in the treatment response to selective serotonin reuptake inhibitors or between patients with MDD and control subjects.
authors.affiliation: University of Tampere, Medical School, Tampere, Finland. ari.illi@uta.fi
authors.forename: Ari
authors.initials: A
authors.lastname: Illi
authors.forename: Eija
authors.initials: E
authors.lastname: Setälä-Soikkeli
authors.forename: Olli
authors.initials: O
authors.lastname: Kampman
authors.forename: Merja
authors.initials: M
authors.lastname: Viikki
authors.forename: Timo
authors.initials: T
authors.lastname: Nuolivirta
authors.forename: Outi
authors.initials: O
authors.lastname: Poutanen
authors.forename: Heini
authors.initials: H
authors.lastname: Huhtala
authors.forename: Nina
authors.initials: N
authors.lastname: Mononen
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
authors.forename: Esa
authors.initials: E
authors.lastname: Leinonen
mesh_terms: D002394:Catechol O-Methyltransferase / Q000235:genetics*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics*; D005387:Finland; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008715:Methionine / Q000235:genetics*; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D014633:Valine / Q000235:genetics*
chemical_list: D002394:Catechol O-Methyltransferase; D008715:Methionine; D017367:Selective Serotonin Reuptake Inhibitors; D014633:Valine