Renal failure due to combined cast nephropathy, amyloidosis and light-chain deposition disease.
Renal dysfunction commonly occurs in multiple myeloma (MM) and is caused by deposition of abnormal light chain within various compartments of the kidney. Renal pathologic findings are diverse and include cast nephropathy (CN), amyloidosis and light-chain deposition disease (LCDD). We report a case of renal failure in a patient with MM caused by concurrent CN, amyloidosis and LCDD which has not been previously described.
Lorenz
Elizabeth C
EC
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Sethi
Sanjeev
S
Poshusta
Tanya L
TL
Ramirez-Alvarado
Marina
M
Kumar
Shaji
S
Lager
Donna J
DJ
Fervenza
Fernando C
FC
Leung
Nelson
N
D000328:Adult; D000686:Amyloidosis / Q000150:complications*; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007147:Immunoglobulin Light Chains; D007674:Kidney Diseases / Q000150:complications*; D009101:Multiple Myeloma / Q000150:complications*; D051437:Renal Insufficiency / Q000209:etiology* / Q000628:therapy
D007147:Immunoglobulin Light Chains