[Expression of adhension molecule CD146 in renal tubular epithelial cells and its clinical significance in IgA nephropathy].
OBJECTIVE
To detect the expression of adhension molecule CD146 in renal tubular epithelial cells and its clinical significance in IgA nephropathy.


METHODS
The expression level of CD146 was measured by immunochemistry method in serial sections of 44 specimens from the patients with biopsy-proven IgA nephropathy. The relationship between CD146 expression and clinicopathological changes was analyzed.


RESULTS
CD146 was mainly expressed in renal tubular epithelial cells, also slightly in the endothelial cells of peritubular capillary and smooth muscle cells. The expression of CD146 had no relationship with Lee's grade of IgA nephropathy, but positively correlated with 24-hour urine protein(r = 0.381, P = 0.011), hypertention, serum creatinine, triglyceride (Z = -2.738, -2.166, - 2.313, P = 0.006, 0.030, 0.021), index of glomerular sclerosis (r = 0 410, P = 0.006), degree of interstitial fibrosi s (r = 0.311, P = 0.040).


CONCLUSIONS
CD146 might play an important role in the progression of renal interstitial fibrosis.
Ji
Ling
L
Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, China.
Wu
Gui-Ming
GM
Yang
Li-Chuan
LC
Li
Ling
L
Xu
Huan
H
D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D051929:CD146 Antigen / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism*; D005260:Female; D005922:Glomerulonephritis, IGA / Q000378:metabolism*; D006801:Humans; D007684:Kidney Tubules / Q000166:cytology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D051929:CD146 Antigen; C497902:MCAM protein, human