title: Phenolic compounds from Cryptocarya konishii: their cytotoxic and tyrosine kinase inhibitory properties.
abstract: Two chalcone derivatives, 2'-hydroxychalcone (1) and desmethylinfectocaryone (2), together with five known phenolic compounds infectocaryone (3), cryptocaryone (4), kurzichalcolactone A (5), pinocembrin (6) and trans-N-feruloyltyramine (7), were isolated from the methanol extract of the wood of Cryptocarya konishii. The structures of the new compounds were determined based on the analysis of spectroscopic data, including UV, IR, 1D and 2D NMR, and mass spectra. Evaluation of the cytotoxic and tyrosine kinase inhibitory activities of compounds 1-7 showed that compounds 2-4 strongly inhibited the growth of murine leukemia P-388 cells, whereas compound 4 significantly inhibited the enzyme.
authors.affiliation: Natural Products Research Group, Department of Chemistry, Bandung Institute of Technology, Jalan Ganeca 10, Bandung, Indonesia.
authors.forename: Fera
authors.initials: F
authors.lastname: Kurniadewi
authors.forename: Lia D
authors.initials: LD
authors.lastname: Juliawaty
authors.forename: Yana M
authors.initials: YM
authors.lastname: Syah
authors.forename: Sjamsul A
authors.initials: SA
authors.lastname: Achmad
authors.forename: Euis H
authors.initials: EH
authors.lastname: Hakim
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Koyama
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kinoshita
authors.forename: Kunio
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D031369:Cryptocarya; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D003603:Cytotoxins; D010636:Phenols; D010936:Plant Extracts; D047428:Protein Kinase Inhibitors; D011505:Protein-Tyrosine Kinases