Nitroglycerin enhances vascular blood flow and drug delivery in hypoxic tumor tissues: analogy between angina pectoris and solid tumors and enhancement of the EPR effect.
Maeda
Hiroshi
H
Faculty of Pharmaceutical Sciences, Sojo University, Ikeda 4-22-1, Kumamoto 860-0082, Japan. hirmaeda@ph.sojo-u.ac.jp
D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001783:Blood Flow Velocity / Q000187:drug effects; D003287:Contrast Media / Q000493:pharmacokinetics; D003326:Coronary Circulation / Q000187:drug effects; D004337:Drug Carriers / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology; D007459:Iodized Oil / Q000493:pharmacokinetics; D009206:Myocardium / Q000378:metabolism; D009369:Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging / Q000378:metabolism / Q000517:prevention & control*; D005996:Nitroglycerin / Q000493:pharmacokinetics / Q000494:pharmacology*; D010539:Permeability; D011859:Radiography
D000970:Antineoplastic Agents; D003287:Contrast Media; D004337:Drug Carriers; D007459:Iodized Oil; D005996:Nitroglycerin