title: Reliability of self-reported diagnostic radiation history  in BRCA1/2 mutation carriers.
abstract: We assessed reliability of self-reported diagnostic radiation history in BRCA1/2 mutation carriers with and without breast cancer. Within the frame-work of the HEBON study, 401 BRCA1/2 mutation carriers completed a baseline (1999-2004) and a follow-up questionnaire (2006-2007). Test-retest reliability of self-reported exposure to chest X-rays, fluoroscopies and mammograms was assessed for the entire study population and by case status.Overall proportion agreement on reporting ever/never exposure was good ([75%), while the corresponding kappa coefficients were between 0.40 and 0.75, indicating at least moderate reliability beyond chance. Reliability of number of exposures was also good ([75%). Proportion agreement on reporting age at first mammogram was low(40%) for exact consistency and moderate (60%) for consistency +/- 1 year. Reliability of age at first mammogram was higher for cases than for unaffected carriers(P\0.001) but this difference disappeared when excluding diagnostic mammograms (P = 0.60). In unaffected carriers proportion agreement on age at last mammogram was 50%. In general, the direction of disagreement on all items was equally distributed. More consistent reporting was mainly determined by a younger age at questionnaire completion. In conclusion, inconsistent self-report of diagnostic radiation by BRCA1/2 mutation carriers was mainly non-differential by disease status.
authors.affiliation: Department of Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands.
authors.forename: Anouk
authors.initials: A
authors.lastname: Pijpe
authors.forename: Peggy
authors.initials: P
authors.lastname: Manders
authors.forename: Renée L
authors.initials: RL
authors.lastname: Mulder
authors.forename: Flora E
authors.initials: FE
authors.lastname: van Leeuwen
authors.forename: Matti A
authors.initials: MA
authors.lastname: Rookus
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics; D015331:Cohort Studies; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006801:Humans; D016015:Logistic Models; D008327:Mammography / Q000706:statistics & numerical data*; D008487:Medical History Taking; D011939:Mental Recall; D008875:Middle Aged; D009426:Netherlands; D011829:Radiation Dosage; D013902:Radiography, Thoracic / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D055815:Young Adult