Does maternal treatment with zidovudine affect changes in mandibles of newborns? Laser induced fluorescence study.
The influence of antiretroviral drug zidovudine treatment during pregnancy on mandible development in newborn rats was studied. The fluorescence of mandibles from 7-, 14- and 28-days old individuals was measured by means of fiber-optical fluorescence analyzer with 407 nm laser excitation. Obtained results revealed disturbing effect of maternal zidovudine administration on mandible fluorescence intensity which should decrease with bone development. Small changes in fluorescence of porphyrin forms are maintaining in the first month of newborns life while the changes observed in 440-585 nm range disappear.
Drzazga
Zofia Krystyna
ZK
Chełkowski's Institute of Physics, Department of Medical Physics, University of Silesia, 40 007 Katowice, ul. Uniwersytecka 4, Poland. Zofia.Drzazga@us.edu.pl
Maciejewska
Karina
K
Michalik
Katarzyna
K
Kaszuba
Michał
M
Nowińska
Barbara
B
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001846:Bone Development / Q000187:drug effects; D005260:Female; D007834:Lasers; D008334:Mandible / Q000187:drug effects*; D018811:Maternal Exposure; D009035:Mothers; D055100:Optical Fibers; D011166:Porphyrins; D011247:Pregnancy; D051381:Rats; D013050:Spectrometry, Fluorescence / Q000295:instrumentation / Q000379:methods*; D015215:Zidovudine / Q000008:administration & dosage / Q000494:pharmacology*
D011166:Porphyrins; D015215:Zidovudine