[Testing of antibodies against serogroup C Neisseria meningitidis by serum bactericidal assay in healthy population, Liaoning province].
OBJECTIVE
To test the serum antibodies from healthy population by Serum Bactericidal Assay (SBA), in order to evaluate the level of protective antibodies against serogroup C Neisseria meningitidis in Liaoning province.


METHODS
240 serum samples were selected from eight age-group randomly. Serogroup C vaccine candidate strain (C11) and the prevail serogroup C strain (053442) were used for SBA.


RESULTS
48.33% of 240 serum samples were positive (titer > or = 1:2) to C11 vaccine strain. Protective rate of SBA was 35.83% (titer > or = 1:8), in which, > or = 6 years old were 13.33%, 7-19 years old was 61.67%, 20-39 years old were 46.67% and > or = 40 years old were 63.33%. Rate of SBA to 053442 was lower than that to C11 in the group over 15 years old by statistic analysis.


CONCLUSIONS
Population under 6 years old showed lower SBA capacities. With the implemention of Expanded Program on Immunization, children under 3 years old should be considered how to give them meningococcal vaccine in order to improve the titer of antibodies against Neisseria meningitidis serogroup C.
An
Shu-Yi
SY
Liaoning Provincial Center for Disease Control and Prevention, Shenyang 110005, Liaoning, China.
Xu
Li
L
Li
Yi-Xing
YX
D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology / Q000494:pharmacology*; D001770:Blood Bactericidal Activity; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008589:Meningococcal Infections / Q000097:blood* / Q000276:immunology* / Q000382:microbiology; D008875:Middle Aged; D038542:Neisseria meningitidis, Serogroup C / Q000187:drug effects* / Q000276:immunology; D011159:Population Surveillance; D055815:Young Adult
D000907:Antibodies, Bacterial