Women rule.
Female animals tolerate trauma and hemorrhage better than male animals AND Estrogen has rapid nongenomic effects that protect organs from damage and attenuate insult-induced inflammation MOREOVER The survival deficit from trauma and hemorrhage produced in ovariectomized female animals is repaired with administration of exogenous estrogen AND Women survive injury, sepsis, and trauma-hemorrhage-induced hypoxemia/reperfusion better than men THEREFORE Women rule ... in survival after trauma, thus, men would benefit from being more like women.
Bullard
M Kelley
MK
Department of Surgery, University of California, San Francisco-East Bay, San Francisco, CA, USA. kelley.bullard@ucsfmedctr.org
Bir
Natasha
N
Kwan
Rita
R
Cureton
Elizabeth
E
Knudson
Peggy
P
Harken
Alden
A
D000818:Animals; D004958:Estradiol / Q000494:pharmacology / Q000627:therapeutic use*; D004967:Estrogens / Q000378:metabolism* / Q000627:therapeutic use; D019317:Evidence-Based Medicine; D005260:Female; D006321:Heart / Q000187:drug effects; D006801:Humans; D008168:Lung / Q000187:drug effects; D008297:Male; D015427:Reperfusion Injury / Q000378:metabolism / Q000401:mortality*; D018805:Sepsis / Q000378:metabolism / Q000401:mortality*; D012727:Sex Characteristics
D004967:Estrogens; D004958:Estradiol