title: The effect of nebivolol on atherogenesis in apoE-knockout mice.
abstract: Nebivolol is a novel beta1-blocker with a nitric oxide (NO)--potentiating, vasodilatory effect that is unique among beta-blockers. It was already shown that nebivolol ameliorates atherosclerosis in cholesterol-fed rabbits. We, therefore, wanted to investigate whether this is the case in the fine experimental model of atherosclerosis: apolipoprotein E (apoE)-knockout mice. Nebivolol attenuated atherogenesis, measured both by "en face" method (9.23+/-1.8% vs. 14.6+/-2.1%) and "cross-section" method (63125+/-8455 microm(2) vs. 91416+/-8357 m(2)). This is the first report showing the effect of nebivolol on atherogenesis in gene-targeted mice.
authors.affiliation: Jagiellonian University Medical College, Cracow, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Kus
authors.forename: M
authors.initials: M
authors.lastname: Gajda
authors.forename: G
authors.initials: G
authors.lastname: Pyka-Fosciak
authors.forename: J
authors.initials: J
authors.lastname: Toton-Zuranska
authors.forename: M
authors.initials: M
authors.lastname: Pawlowska
authors.forename: M
authors.initials: M
authors.lastname: Suski
authors.forename: A
authors.initials: A
authors.lastname: Niepsuj
authors.forename: B
authors.initials: B
authors.lastname: Nowak
authors.forename: P
authors.initials: P
authors.lastname: Wolkow
authors.forename: R
authors.initials: R
authors.lastname: Olszanecki
authors.forename: J
authors.initials: J
authors.lastname: Jawien
authors.forename: R
authors.initials: R
authors.lastname: Korbut
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000473:pathology; D001057:Apolipoproteins E / Q000172:deficiency / Q000235:genetics; D050197:Atherosclerosis / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D001578:Benzopyrans / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D051379:Mice; D018345:Mice, Knockout; D000068577:Nebivolol; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D000319:Adrenergic beta-Antagonists; D001057:Apolipoproteins E; D001578:Benzopyrans; D004983:Ethanolamines; D014280:Triglycerides; D014665:Vasodilator Agents; D000068577:Nebivolol; D002784:Cholesterol