title: [The antioxidant characteristics of medicinal plant extracts from Western Siberia].
abstract: An antioxidant activity of the water-alcohol extracts of leaves of ten herbs from Western Siberia was studied. In vivo the capability of extracts to protect cells of Escherichia coli against the bacteriostatic action of H2O2 and the influence of the extracts on the expression of the antioxidant gene katG coding catalase-hydroperoxidase I were investigated. In vitro the radical-binding activity with DPhPG (1,1-diphenyl-2-picrylhydrazyl radical), the chelating capability with ferrozine, and total composition of flavonoids and tannins were determined. The extracts of Filipendula stepposa and Limonium gmelinii were characterized by the highest antioxidant activity. According to data, the test extracts could have an antioxidant effect on bacteria in different ways at once including the direct inhibition of ROS (reactive oxygen species), iron ion chelation and antioxidant gene induction.
authors.forename: G V
authors.initials: GV
authors.lastname: Smirnova
authors.forename: G I
authors.initials: GI
authors.lastname: Vysochina
authors.forename: N G
authors.initials: NG
authors.lastname: Muzyka
authors.forename: Z Iu
authors.initials: ZIu
authors.lastname: Samoĭlova
authors.forename: T A
authors.initials: TA
authors.lastname: Kukushkina
authors.forename: O N
authors.initials: ON
authors.lastname: Oktiabr'skiĭ
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002374:Catalase; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics / Q000254:growth & development*; D029968:Escherichia coli Proteins; D031984:Filipendula / Q000737:chemistry*; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000235:genetics; D018384:Oxidative Stress / Q000187:drug effects* / Q000235:genetics; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D029606:Plumbaginaceae / Q000737:chemistry*; D012800:Siberia
chemical_list: D000975:Antioxidants; D029968:Escherichia coli Proteins; D010936:Plant Extracts; D002374:Catalase; C051253:katG protein, E coli