Cross-couplings between benzylic and aryl halides "on water": synthesis of diarylmethanes.
A remarkably simple entry to unsymmetrical diarylmethanes has been developed that relies on an in situ organozinc-mediated, palladium-catalyzed cross-coupling. Thus, by mixing a benzyl and aryl halide together in the presence of Zn metal and a Pd catalyst, diarylmethanes are formed at room temperature without assistance by a surfactant; hence, "on water".
Duplais
Christophe
C
Department of Chemistry & Biochemistry, University of California, Santa Barbara, CA 93106, USA.
Krasovskiy
Arkady
A
Wattenberg
Alina
A
Lipshutz
Bruce H
BH
D002384:Catalysis; D006219:Halogens / Q000138:chemical synthesis / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D014867:Water / Q000737:chemistry; D015032:Zinc / Q000737:chemistry
D006219:Halogens; D006841:Hydrocarbons, Aromatic; D014867:Water; D010165:Palladium; D015032:Zinc; D008697:Methane