[Effects of general glycosides in Cynanchum auriculatum of Jiangsu province on liver fibrosis of rats].
OBJECTIVE
To investigate the effect of general glycosides from Cynanchun auriculatum of Jiangsu on liver fibrosis of rats.


METHODS
Seventy-two Wistar rats were randomly divided into normal group, model group, BSW three doses treated group and hydrocortisone treated group. CCl4 (50%, 2 mL x kg(-1)) was orally administraeated twice a week for 8 weeks. The liver and spleen indices were observed. The level of serum GPT, GOT, and HA, PCIII and the level of SOD, HyP, MDA in liver homogenates was also measured. The histopathologic change in hepatic of rats was examined.


RESULTS
The elevation of serum GPT, GOT, HA, PCIll, MDA and HyP and the content of liver homogenates were attanuated remarkably by BSW treatment. BSW groups also increased the level of SOD of liver homogenates, and make the fibrotic liver better.


CONCLUSIONS
The general glycosides in C. auriculatum of jiangsu province have an anti-hepatic fibrosis ettect on CCl4-induced fibrosis rats, the mechanisms might be associated with its anti-oxidative action.
Lv
Weihong
W
Medical and Pharmaceutical Institute of Yangzhou University, Yangzhou 225001, China. lwh8412@126.com
Zhang
Aixiang
A
Xu
Shan
S
Zhang
Hongquan
H
D000818:Animals; D002681:China; D031105:Cynanchum / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D006027:Glycosides / Q000008:administration & dosage*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D006027:Glycosides