Comparison of treatment of cherry angiomata with pulsed-dye laser, potassium titanyl phosphate laser, and electrodesiccation: a randomized controlled trial.
OBJECTIVE
To assess the comparative efficacy of energy treatments in resolving cherry angiomata.


METHODS
Rater-blinded randomized controlled trial.


METHODS
Outpatient dermatology clinic in an urban referral academic medical center.


METHODS
Fifteen healthy adults aged 21 to 65 years were enrolled. Two eligible individuals who were approached declined to participate, and no one enrolled was withdrawn for adverse effects.


METHODS
For each participant, 3 areas on the torso were demarcated such that each area contained 4 cherry angiomata. Each area was then randomly assigned to receive 1 of the 3 treatments: pulsed-dye laser (PDL) (595 nm), potassium titanyl phosphate (KTP) laser (532 nm), or electrodesiccation. Two treatments spaced 2 weeks apart were delivered to each area.


METHODS
Standardized photographs from before treatment and 3 months after the last treatment were evaluated for color and texture on visual analog scales.


RESULTS
Mean change in color was a significant improvement of 7.77 (P<.001), but there was no significant difference across treatment arms (P=.19). Mean change in texture was a significant improvement of 6.23 (P<.001), and the degree of textural change also differed across treatments (P<.001). In pairwise comparisons, cherry angiomata treated with electrodesiccation were significantly less improved than were those receiving KTP laser (P=.003) and those treated with PDL (P=.001). The effects of KTP laser and PDL on texture were not different (P=.50).


CONCLUSIONS
Cherry angiomata can be effectively treated with electrodesiccation and with laser. Laser, especially PDL, may minimize the likelihood of treatment-associated textural change. Trial Registration clinicaltrials.gov Identifier: NCT00509977.
Collyer
James
J
Department of Dermatology, Feinberg School of Medicine, Northwestern University, 676 N St Clair St, Ste 1600, Chicago, IL 60611, USA.
Boone
Susan L
SL
White
Lucile E
LE
Rademaker
Alfred
A
West
Dennis P
DP
Anderson
Kyle
K
Kim
Natalie A
NA
Smith
Scott
S
Yoo
Simon
S
Alam
Murad
M
D000328:Adult; D000368:Aged; D000798:Angiomatosis / Q000473:pathology / Q000628:therapy*; D003890:Desiccation / Q000379:methods*; D004311:Double-Blind Method; D004598:Electrosurgery / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy / Q000295:instrumentation*; D054025:Lasers, Dye / Q000627:therapeutic use*; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult