title: [Successful treatment of chronic disseminated intravascular coagulation syndrome with continuous subcutaneous infusion of heparin using a mobile infusion pump: report of 2 cases].
abstract: We report here two patients with chronic disseminated intravascular coagulation (chronic DIC) secondary to aortic aneurysm, who were successfully treated with continuous subcutaneous infusion of heparin. The patients were 69- and 89-year-old males, who were admitted to our hospital because of thrombocytopenia and marked bleeding tendency. The underlying conditions were aortic dissection and aortic aneurysm, respectively. Coagulation test demonstrated that these patients had DIC, and a diagnosis of chronic DIC secondary to aortic aneurysm was made. Anti-coagulation treatment with oral camostat mesylate and daily subcutaneous infusion of heparin calcium was started. However, the treatment was insufficient to control chronic DIC, and these patients developed recurrent severe subcutaneous hemorrhages. Therefore, we attempted continuous subcutaneous infusion of heparin using a mobile infusion pump. This delivery of heparin markedly improved the coagulopathy, and the hemorrhagic episode disappeared with good compliance in the use of infusion equipment in these patients. Continuous subcutaneous infusion of heparin using a mobile infusion pump is effective and useful for long term treatment of chronic DIC by the outpatient department.
authors.affiliation: Department of Hematology, Kobe City Medical Center, General Hospital.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Togami
authors.forename: Yuya
authors.initials: Y
authors.lastname: Nagai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Arima
authors.forename: Sonoko
authors.initials: S
authors.lastname: Shimoji
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kimura
authors.forename: Daichi
authors.initials: D
authors.lastname: Inoue
authors.forename: Minako
authors.initials: M
authors.lastname: Mori
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Fujita
authors.forename: Sumie
authors.initials: S
authors.lastname: Tabata
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kurata
authors.forename: Soshi
authors.initials: S
authors.lastname: Yanagida
authors.forename: Akiko
authors.initials: A
authors.lastname: Matsushita
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nagai
authors.forename: Shuichiroh
authors.initials: S
authors.lastname: Kaji
authors.forename: Takayuki
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000784:Aortic Dissection / Q000150:complications; D000925:Anticoagulants / Q000008:administration & dosage*; D001014:Aortic Aneurysm / Q000150:complications; D002908:Chronic Disease; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy* / Q000209:etiology; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007260:Infusion Pumps; D055104:Infusions, Subcutaneous; D008297:Male; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D006493:Heparin