title: Expression of placenta growth factor: an independent factor for prediction of progression and prognosis of oral cancer.
abstract: BACKGROUND
  Expression of placenta growth factor (PlGF) is found to correlate with the progression and prognosis of several human cancers.
  
  
  METHODS
  This study used an immunohistochemical technique to examine the expression of PlGF in 100 specimens of oral squamous cell carcinoma (OSCC).
  
  
  RESULTS
  We found that the higher mean PlGF labeling index was significantly associated with OSCCs with positive lymph node metastasis (p = .014) or with more advanced clinical stages (p = .016). Positive lymph node metastasis (p = .008) and PlGF labeling index >40% (p = .010) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. Moreover, a Kaplan-Meier curve showed that OSCC patients with a PlGF labeling index >40% had a significantly poorer cumulative survival than those with a PlGF labeling index ≤40% (log-rank test, p = .003).
  
  
  CONCLUSIONS
  The PlGF labeling index can predict the progression and prognosis of OSCCs in Taiwan.
authors.affiliation: Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
authors.forename: Shih-Jung
authors.initials: SJ
authors.lastname: Cheng
authors.forename: Jang-Jaer
authors.initials: JJ
authors.lastname: Lee
authors.forename: Sang-Heng
authors.initials: SH
authors.lastname: Kok
authors.forename: Chia-Hsuan
authors.initials: CH
authors.lastname: Chou
authors.forename: Hao-Hueng
authors.initials: HH
authors.lastname: Chang
authors.forename: Meng Ling
authors.initials: ML
authors.lastname: Chiang
authors.forename: Hsin-Ming
authors.initials: HM
authors.lastname: Chen
authors.forename: Mark Yen-Ping
authors.initials: MY
authors.lastname: Kuo
authors.forename: Chun-Pin
authors.initials: CP
authors.lastname: Chiang
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D015999:Multivariate Analysis; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000378:metabolism*; D011379:Prognosis
chemical_list: C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor