title: Synthesis of beta-aminoketones and construction of highly substituted 4-piperidones by mannich reaction induced by persistent radical cation salts.
abstract: A Mannich reaction of imines and ketones induced by persistent radical cation salts was investigated, and a series of Mannich bases, beta-aminoketones, were synthesized. A novel cyclization to form the 4-piperidone skeleton was achieved in a tandem process. The reaction can be rationalized as a radical cation process supported by various evidence.
authors.affiliation: Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China. jiaxd1975@163.com
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Jia
authors.forename: Xiao-E
authors.initials: XE
authors.lastname: Wang
authors.forename: Cai-Xia
authors.initials: CX
authors.lastname: Yang
authors.forename: Cong-De
authors.initials: CD
authors.lastname: Huo
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Ren
authors.forename: Xi-Cun
authors.initials: XC
authors.lastname: Wang