Interaction of methylenetetrahydrofolate reductase genotype and smoking habit in Taiwanese lung cancer patients.
The aim of this study was to evaluate the association and interaction of genotypic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and environmental factors with lung cancer in Taiwan. Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed in association with lung cancer susceptibility, and discussed their joint effects with individual habits on lung cancer risk.


METHODS
In total, 358 patients with lung cancer and 716 healthy controls recruited from the China Medical Hospital in central Taiwan were genotyped.


RESULTS
The MTHFR C677T genotype, but not the A1298C, was differently distributed between the lung cancer and control groups. The T allele of MTHFR C677T was significantly more frequently found in controls than in cancer patients. As for A1298C polymorphism, there was no difference in distribution between the lung cancer and control groups. Gene interactions with smoking were significant for MTHFR C677T polymorphism. The MTHFR C677T CT and TT genotypes in association with smoking conferred a decreased risk of 0.706 (95% confidence interval=0.531-0.939) for lung cancer.


CONCLUSIONS
Our results provide the first evidence that the C allele of MTHFR C677T may be associated with the development of lung cancer and may be a novel useful marker for primary prevention and anticancer intervention.
Liu
Chiu-Shong
CS
Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Tsai
Chia-Wen
CW
Hsia
Te-Chun
TC
Wang
Rou-Fen
RF
Liu
Chin-Jung
CJ
Hang
Liang-Wen
LW
Chiang
Su-Yin
SY
Wang
Chung-Hsing
CH
Tsai
Ru-Yin
RY
Lin
Cheng-Chieh
CC
Bau
Da-Tian
DT
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D013624:Taiwan / Q000453:epidemiology
D042965:Methylenetetrahydrofolate Reductase (NADPH2)