Maternal and umbilical resistin levels do not correlate with infant birth weight either in normal pregnancies and or in pregnancies complicated with gestational diabetes.
OBJECTIVE
To evaluate the role of resistin in the pathophysiology of insulin resistance during pregnancy and on the birth weight of infants born from women with gestational diabetes (GDM).


METHODS
Thirty women diagnosed with GDM were compared to 30 normal pregnant controls. Maternal serum resistin and insulin levels were measured at the time of the oral glucose tolerance test screening. In addition, umbilical levels of resistin and insulin were measured at the time of delivery.


RESULTS
There was no difference in maternal serum resistin levels in women with GDM as compared to normal controls at 24-26 weeks. There was no difference in umbilical resistin levels between the infants born in the two groups. There was no correlation between infant weight and either maternal resistin at 24-26 week or umbilical resistin levels.


CONCLUSIONS
There were no significant differences in umbilical resistin levels between infants born of women with GDM as compared to normal pregnant women. In addition, there was no correlation between resistin levels during pregnancy, as well as between umbilical resistin levels and neonatal birth weight. In conclusion, resistin seems to play a rather minor role in the pathophysiology of GDM and the energy metabolism during fetal life.
Vitoratos
Nikolaos
N
2nd Department of Obstetric and Gynecology, School of Medicine, University of Athens, Aretaieion University Hospital, 76 Vas. Sofias Av., Athens, Greece. nikolasvitoratos@yahoo.gr
Dimitrakaki
Alexandra
A
Vlahos
Nikolaos F
NF
Gregoriou
Odysseas
O
Panoulis
Kostantinos
K
Christopoulos
Panagiotis
P
Creatsas
George
G
D000328:Adult; D001724:Birth Weight / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood* / Q000209:etiology; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D005312:Fetal Blood / Q000737:chemistry* / Q000378:metabolism; D005333:Fetus / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D009035:Mothers; D011247:Pregnancy / Q000097:blood*; D052243:Resistin / Q000032:analysis / Q000097:blood* / Q000502:physiology
D001786:Blood Glucose; D007328:Insulin; C499624:RETN protein, human; D052243:Resistin