A novel ultra-porous titanium dioxide ceramic with excellent biocompatibility.
The current study compares biocompatibility, cell growth and morphology, pore diameter distribution, and interconnectivity of a novel titanium dioxide (TiO(2)) bone graft substitute granules with three different commercially available bone graft granules Natix, Straumann BoneCeramic, and Bio-Oss. Human primary mesenchymal stem cells were cultured on the bone graft substitutes and cell viability and proliferation were evaluated after 1 and 3 days. The microstructural properties of the bone graft substitutes were evaluated by scanning electron microscopy, micro-computed tomography analysis, and mechanical testing. The cell viability and proliferation, porosity, interconnectivity, open pore size, and surface area-to-volume ratio of TiO(2) granules were significantly higher than commercial bone granules (Bio-Oss and Straumann BoneCeramic).
Sabetrasekh
Roya
R
Department for Biomaterials, Faculty for Dentistry, University of Oslo NO-0317 Oslo, Norway.
Tiainen
Hanna
H
Lyngstadaas
S Petter
SP
Reseland
Janne
J
Haugen
Håvard
H
D001672:Biocompatible Materials / Q000032:analysis / Q000737:chemistry*; D018786:Bone Substitutes / Q000032:analysis* / Q000737:chemistry*; D016025:Bone Transplantation; D049109:Cell Proliferation; D002470:Cell Survival; D002516:Ceramics / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing / Q000379:methods; D059630:Mesenchymal Stem Cells / Q000166:cytology; D008855:Microscopy, Electron, Scanning / Q000379:methods; D008903:Minerals / Q000032:analysis* / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry; D016062:Porosity; D014025:Titanium / Q000032:analysis* / Q000737:chemistry*
C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D008903:Minerals; C577189:Natix; D011140:Polyurethanes; C009495:titanium dioxide; C028279:polyurethane foam; D014025:Titanium