title: Hepatoprotective constituents from the roots and stems of Erycibe hainanesis.
abstract: Eleven new diglycosides, erycibosides A-K (1-11), four new chlorogenic acid derivatives (14-17), and a new bis-coumarin (18), together with 21 known compounds, have been isolated from an EtOH extract of the roots and stems of Erycibe hainanesis. Their structures were elucidated by means of spectroscopic methods and chemical evidence. Inhibitory activities of some of the compounds on d-galactosamine-induced cytotoxicity in WB-F344 rat hepatic epithelial stem-like cells were screened, and compounds 2, 6, 10, 18, and 32 showed potent hepatoprotective activities at concentrations of 1 x 10(-5) to 1 x 10(-4) M.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing 100050, People's Republic of China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Song
authors.forename: Yixiu
authors.initials: Y
authors.lastname: Li
authors.forename: Ziming
authors.initials: Z
authors.lastname: Feng
authors.forename: Jianshuang
authors.initials: J
authors.lastname: Jiang
authors.forename: Peicheng
authors.initials: P
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002726:Chlorogenic Acid / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D027722:Convolvulaceae / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005688:Galactosamine / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D022781:Hepatocytes / Q000187:drug effects*; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D051381:Rats
chemical_list: D003374:Coumarins; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D002726:Chlorogenic Acid; D005688:Galactosamine