title: [Current situation researching of methylation in tumor].
abstract: The disorders of DNA and histone methylation have a close relationship with the development and progression of tumors. Epigenetic regulation is critical in maintaining the stability and integrity of the expression profiles of different cell types by modifying DNA methylation and histone methylation. However, the abnormal changes of methylation often result in the development and progression of tumors. This review summarized the theory of tumor genomic and histone methylation, detection methods of methylation and their applications, and the clinical application of methylation as biological markers and drug targets.
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Beijing 100005, China.
authors.forename: Di
authors.initials: D
authors.lastname: Shao
authors.forename: An-fang
authors.initials: AF
authors.lastname: Cui
authors.forename: Liu-luan
authors.initials: LL
authors.lastname: Zhu
authors.forename: Ai-jun
authors.initials: AJ
authors.lastname: Qiao
authors.forename: Xing-xing
authors.initials: XX
authors.lastname: Kong
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Liu
authors.forename: Yong-sheng
authors.initials: YS
authors.lastname: Chang
authors.forename: Fu-de
authors.initials: FD
authors.lastname: Fang
mesh_terms: D019175:DNA Methylation; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism
chemical_list: D006657:Histones