Successful treatment of acute myelogenous leukemia with favorable cytogenetics by reduced-intensity stem cell transplantation.
Acute myelogenous leukemia (AML) with favorable cytogenetics responds well to chemotherapy. If the leukemia relapses, allogenic hematopoietic stem transplantation (allo-HSCT) is considered as a treatment option. Since the efficacy of reduced-intensity stem cell transplantation (RIST) for AML with favorable cytogenetics has not been established, we retrospectively analyzed the outcomes of allo-HSCT in AML patients according to cytogenetic risks. The outcome of allo-HSCT for AML patients with favorable cytogenetics seemed to be superior to that for AML patients with intermediate cytogenetics. In AML patients with favorable cytogenetics, the 3-year overall survival (OS) and relapse-free survival (RFS) rates were 88 and 76%, respectively, in the RIST group. Both the 3-year OS and RFS rates were 81% in the conventional stem cell transplantation (CST) group. The outcome of RIST for AML patients with favorable cytogenetics was comparable to that for patients who received CST despite the more advanced age and greater organ dysfunction in RIST group than in CST group. None of the patients died within 90 days after RIST. Moreover, there was no relapse in patients with favorable cytogenetics who were in hematological remission prior to RIST. Thus, RIST for AML patients with favorable cytogenetics in remission is safe and effective.
Kondo
Takeshi
T
Stem Cell Transplantation Center, Hokkaido University Hospital, Sapporo 060-8648, Japan. t-kondoh@med.hokudai.ac.jp
Yasumoto
Atsushi
A
Arita
Kotaro
K
Sugita
Jun-Ichi
J
Shigematsu
Akio
A
Okada
Kohei
K
Takahata
Mutsumi
M
Onozawa
Masahiro
M
Kahata
Kaoru
K
Takeda
Yukari
Y
Obara
Masato
M
Yamamoto
Satoshi
S
Endo
Tomoyuki
T
Nishio
Mitsufumi
M
Sato
Norihiro
N
Tanaka
Junji
J
Hashino
Satoshi
S
Koike
Takao
T
Asaka
Masahiro
M
Imamura
Masahiro
M
D000328:Adult; D000368:Aged; D003582:Cytogenetics; D018572:Disease-Free Survival; D005260:Female; D006086:Graft vs Host Disease / Q000401:mortality; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D019172:Transplantation Conditioning / Q000379:methods*; D055815:Young Adult