Role of Krüppel-like factor 4 in phenotypic switching and proliferation of vascular smooth muscle cells.
Phenotypic switching and proliferation of vascular smooth muscle cells (VSMCs) are critical components in the development of many vascular proliferation diseases such as atherosclerosis and restenosis after percutaneous coronary interventions. Krüppel-like factor 4 (KLF4) has been shown to play a key role in VSMC proliferation and differentiation. The focus of this review is to provide an overview for understanding the physiological and pathobiological roles of KLF4 in phenotypic switching and proliferation of VSMCs.
Zheng
Bin
B
Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, China.
Han
Mei
M
Wen
Jin-Kun
JK
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology*; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D010641:Phenotype
C000715467:KLF4 protein, human; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors