Dental enamel: genes define biomechanics.
Regulated gene expression assembles an extracellular proteinaceous matrix to control biomineralization and the resultant biomechanical function of tooth enamel. The importance of the dominant enamel matrix protein, amelogenin (Amel); a minor transiently expressed protein, dentin sialoprotein (Dsp); an electrogenic sodium bicarbonate cotransporter (NBCe1); the timely removal of the proteinaceous matrix by a serine protease, Kallikrein-4 (Klk4); and the late-stage expression of Amelotin (Amtn) on enamel biomechanical function were demonstrated and measured using mouse models.
Rauth
Rick J
RJ
University of California, Los Angeles, School of Dentistry, USA.
Potter
Karen S
KS
Ngan
Amanda Y-W
AY
Saad
Deema M
DM
Mehr
Rana
R
Luong
Vivian Q
VQ
Schuetter
Verna L
VL
Miklus
Vetea G
VG
Chang
PeiPei
P
Paine
Michael L
ML
Lacruz
Rodrigo S
RS
Snead
Malcolm L
ML
White
Shane N
SN
D053523:Amelogenin / Q000235:genetics; D000818:Animals; D001696:Biomechanical Phenomena; D003743:Dental Enamel / Q000502:physiology*; D003746:Dental Enamel Proteins / Q000235:genetics*; D016326:Extracellular Matrix Proteins / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics; D007610:Kallikreins / Q000235:genetics; D051379:Mice; D023421:Models, Animal; D010750:Phosphoproteins / Q000235:genetics; D012795:Sialoglycoproteins / Q000235:genetics; D027982:Sodium-Bicarbonate Symporters / Q000235:genetics; D014074:Tooth Calcification / Q000235:genetics; D000099311:Dentin Sialophosphoprotein
D053523:Amelogenin; D003746:Dental Enamel Proteins; D016326:Extracellular Matrix Proteins; D007610:Kallikreins; D010750:Phosphoproteins; D012795:Sialoglycoproteins; D027982:Sodium-Bicarbonate Symporters; D000099311:Dentin Sialophosphoprotein; C507066:Amtn protein, mouse; C120801:kallikrein 4