Integrating phenotype ontologies across multiple species.
Phenotype ontologies are typically constructed to serve the needs of a particular community, such as annotation of genotype-phenotype associations in mouse or human. Here we demonstrate how these ontologies can be improved through assignment of logical definitions using a core ontology of phenotypic qualities and multiple additional ontologies from the Open Biological Ontologies library. We also show how these logical definitions can be used for data integration when combined with a unified multi-species anatomy ontology.
Mungall
Christopher J
CJ
Genome Dynamics Department, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. cjm@berkeleybop.org
Gkoutos
Georgios V
GV
Smith
Cynthia L
CL
Haendel
Melissa A
MA
Lewis
Suzanna E
SE
Ashburner
Michael
M
D000465:Algorithms; D000818:Animals; D001331:Automation; D002874:Chromosome Mapping / Q000379:methods*; D019295:Computational Biology / Q000379:methods; D016678:Genome; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D051379:Mice; D008954:Models, Biological; D010641:Phenotype; D012984:Software; D013045:Species Specificity