In vitro postantibiotic effects of tomopenem (CS-023) against Staphylococcus aureus and Pseudomonas aeruginosa.
The postantibiotic effect (PAE) of tomopenem was determined after a 2 h exposure of two strains of meticillin-susceptible and meticillin-resistant Staphylococcus aureus (MSSA and MRSA), and imipenem-susceptible and imipenem-resistant Pseudomonas aeruginosa, to tenfold the respective MIC. The PAEs on MSSA and P. aeruginosa were approximately 1 h and they were comparable to those of meropenem. The PAE on MRSA was 1.5 to 3 h, equal to or longer than those of vancomycin. The PAEs of tomopenem not only were found for MRSA, but also were present in the imipenem-resistant P. aeruginosa tested.
Tomozawa
Takanori
T
Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd, 1-2-58 Hiromachi,Shinagawa-ku, Tokyo 140-8710, Japan.
Sugihara
Chika
C
Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd, 1-2-58 Hiromachi,Shinagawa-ku, Tokyo 140-8710, Japan.
Kakuta
Masayo
M
Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd, 1-2-58 Hiromachi,Shinagawa-ku, Tokyo 140-8710, Japan.
Sugihara
Kiyoshi
K
Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd, 1-2-58 Hiromachi,Shinagawa-ku, Tokyo 140-8710, Japan.
Koga
Tetsufumi
T
Biological Research Laboratories IV, Daiichi Sankyo Co. Ltd, 1-2-58 Hiromachi,Shinagawa-ku, Tokyo 140-8710, Japan.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D015780:Carbapenems; C492232:tomopenem