Rapid hemostasis of arterial puncture sites with Angio-Seal in patients undergoing percutaneous coronary intervention.
OBJECTIVE
To evaluate the efficacy and safety of Angio-Seal device in achieving rapid hemostasis of the access site after percutaneous coronary intervention (PCI) compared with manual compression.


METHODS
From December 2002 to November 2003, the device was used in 88 nonconsecutive patients underwent PCI, their age was 58 +/- 9 years and 78% were male, and time to hemostasis, time to ambulation and in hospital groin complications were compared to 88 nonconsecutive patients (age 58 +/- 11 years and 77% were male), who had manual compression.


RESULTS
Time to hemostasis is significantly shorter in Angio-Seal group compared with manual compression (1.5 +/- 2.0 minutes vs 38.1 +/- 5.4 minutes, p < 0.0001) despite activated clotting time (319 +/- 37 seconds vs 131 +/- 18 seconds, p < 0.0001). Leg immobilization was 4-6 hours in 98% of patients using the Angio-Seal device. While in patients with manual compression the leg immobilization required 10-14 hours. Time to ambulation was significantly shorter in Angio-Seal group compared with manual compression (5.2 +/- 0.6 hours vs 13.0 +/- 0.7 hours. P < 0.05). There was no difference in overall major complication rate found between the two groups.


CONCLUSIONS
This study showed that the Angio-Seal device rapid hemostasis could be obtained in the arterial puncture sites, so that time to ambulation became much shorter with Angio-Seal compared with manual compression, without any significant differences in groin complications.
Trisnohadi
Hanafi B
HB
Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia-Dr. Cipto Mangunkusumo Hospital, Jakarta.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D003327:Coronary Disease / Q000628:therapy*; D004867:Equipment Design; D005260:Female; D005263:Femoral Artery / Q000601:surgery*; D005500:Follow-Up Studies; D006488:Hemostasis, Surgical / Q000295:instrumentation*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000601:surgery*; D011677:Punctures / Q000379:methods*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome