Human serum albumin coated iron oxide nanoparticles for efficient cell labeling.
A novel dopamine-plus-HSA (human serum albumin) approach was developed to functionalize iron oxide nanoparticles (IONPs), yielding nanoconjugates that are highly efficient in labeling various types of cell lines, which was demonstrated by in vivo MR imaging on xenograft and focal cerebral ischemia models.
Xie
Jin
J
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institute of Health, 31 Center Drive, 31/1C22, Bethesda, MD 20892, USA.
Wang
Jinhua
J
Niu
Gang
G
Huang
Jing
J
Chen
Kai
K
Li
Xingguo
X
Chen
Xiaoyuan
X
D000818:Animals; D002545:Brain Ischemia / Q000175:diagnosis; D002460:Cell Line; D054022:Cerebrum / Q000473:pathology; D004705:Endocytosis; D005290:Ferric Compounds / Q000032:analysis / Q000737:chemistry; D006801:Humans; D008264:Macrophages / Q000737:chemistry / Q000166:cytology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D053758:Nanoparticles / Q000032:analysis / Q000737:chemistry; D051381:Rats; D012709:Serum Albumin / Q000737:chemistry*; D014183:Transplantation, Heterologous
D005290:Ferric Compounds; D012709:Serum Albumin; C000499:ferric oxide