Flavonoids: recent advances as anticancer drugs.
Flavonoids belong to polyphenolic secondary metabolites with broad-spectrum pharmacological activities and extensive biological effects, and the most prominent activity is their potential role as anticancer agents. In recent years, flavonoids and their synthetic analogues have been intensely investigated in the treatment of ovarian, breast, cervical, pancreatic, and prostate cancer. To some extent, chemical structures of flavonoids will influence their anticancer activities. Thus, some new analogues based on the structural skeleton of these flavonoids have been synthesized and investigated. This review presents recent advances on the aspects of the natural flavonoids and their synthetic analogues in the treatment of cancers, and new synthetic approaches and possible structure-activity relationships of flavonoids are also briefly summarized.
Liu
Hai L
HL
Analytical & Testing Center of Beijing Normal University, Beijing 100875, China.
Jiang
Wen B
WB
Xie
Meng X
MX
D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D047188:Chalcones / Q000494:pharmacology / Q000627:therapeutic use; D047309:Flavones / Q000494:pharmacology / Q000627:therapeutic use; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D044948:Flavonols / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008495:Medical Oncology / Q000331:legislation & jurisprudence / Q000639:trends; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy*; D010330:Patents as Topic
D000872:Anthocyanins; D000970:Antineoplastic Agents; D047188:Chalcones; D047309:Flavones; D005419:Flavonoids; D044948:Flavonols