title: Chewing the fat on tumor cell metabolism.
abstract: Tumor cells undergo a metabolic shift toward specific bioenergetic (glycolysis) and anabolic (protein and lipid synthesis) processes that promote rapid growth. Nomura et al. (2010) now demonstrate that an increase in monoacylglycerol lipase (MAGL) drives tumorigenesis through the lipolytic release and remodeling of free fatty acids.
authors.affiliation: Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Yecies
authors.forename: Brendan D
authors.initials: BD
authors.lastname: Manning
mesh_terms: D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008994:Monoacylglycerol Lipases / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D008994:Monoacylglycerol Lipases