Chromosome aberrations after high-dose 131I and 99mTc-MIBI administration using a micronucleus assay.
OBJECTIVE
We evaluated the potential detrimental cytogenetic effects of Tc-methoxyisobutyl isonitrile (MIBI) and I on patients who were exposed to the radiopharmaceutics for cardiac imaging or thyroid cancer therapy, respectively.


METHODS
Mononuclear leukocytes were isolated both before and after radiopharmaceutical administration and subsequently cultured. Micronuclei frequency was then assessed and microscopic evaluation of apoptosis was conducted.


RESULTS
Small statistically insignificant augmentation in the percentage of micronuclei from 10.9+/-3.8 to 11.3+/-2.4% was observed in the Tc-MIBI group. In contrast, I elicited a notable augmentation of micronuclei from 6.3+/-2.2 to 9.6+/-3.1 at 3.7 GBq, and 6+/-1.5 to 9.2+/-2.7 at 5.55 GBq (P<0.05).


CONCLUSIONS
Our results showed that there were no remarkable alterations either in the micronuclei incidence or in the percentage of apoptotic lymphocytes after in-vivo exposure to radiopharmaceutical imaging, which provides evidence to reduce the growing concern about the safety issue of cardiac imaging with Tc-MIBI, whereas the deleterious effects of I must be considered when it is applied to thyroid cancer treatment.
Asli
Isa Neshandar
IN
Department of Nuclear Medicine, Taleghani Hospital.
Mosaffa
Nariman
N
Mogharrabi
Mehdi
M
Hooman
Aref
A
Tabei
Faraj
F
Javadi
Hamid
H
Shafei
Babak
B
Seyedabadi
Mohammad
M
Assadi
Majid
M
D000328:Adult; D002454:Cell Differentiation; D002869:Chromosome Aberrations / Q000528:radiation effects*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage* / Q000009:adverse effects*; D008297:Male; D015162:Micronucleus Tests / Q000379:methods*; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000009:adverse effects; D011829:Radiation Dosage; D017256:Technetium Tc 99m Sestamibi / Q000008:administration & dosage* / Q000009:adverse effects*; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy
D007457:Iodine Radioisotopes; D017256:Technetium Tc 99m Sestamibi