Versatile roles for myosin Va in dense core vesicle biogenesis and function.
The motor protein myosin Va is involved in multiple successive steps in the development of dense-core vesicles, such as in the membrane remodelling during their maturation, their transport along actin filaments and the regulation of their exocytosis. In the present paper, we summarize the current knowledge on the roles of myosin Va in the different steps of dense-core vesicle biogenesis and exocytosis, and compare findings obtained from different cell types and experimental systems.
Kögel
Tanja
T
Department of Biomedicine, University of Bergen, Jonas Lies Vei 91, 5009 Bergen, Norway.
Bittins
Claudia Margarethe
CM
Rudolf
Rüdiger
R
Gerdes
Hans-Hermann
HH
D000818:Animals; D019439:Chromaffin Cells / Q000166:cytology / Q000378:metabolism; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000378:metabolism; D024701:Myosin Type V / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D022142:Secretory Vesicles / Q000378:metabolism*
D024701:Myosin Type V