title: Euphane triterpenoids of Cassipourea lanceolata from the Madagascar rainforest.
abstract: Fractionation of an ethanol extract of a Madagascar collection of the leaves and fruit of Cassipourea lanceolata Tul. led to the isolation of three euphane triterpenoids 1-3. The (1)H and (13)C NMR spectra of all compounds were fully assigned using a combination of 2D NMR experiments, including COSY, TOCSY, HSQC (HMQC), HMBC and ROESY sequences. The three compounds showed weak antiproliferative activities against the A2780 human ovarian cancer cell line, with IC(50) values of 25, 25 and 32 microM, respectively.
authors.affiliation: Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0212, USA.
authors.forename: Yanpeng
authors.initials: Y
authors.lastname: Hou
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
authors.forename: Peggy J
authors.initials: PJ
authors.lastname: Brodie
authors.forename: James S
authors.initials: JS
authors.lastname: Miller
authors.forename: Chris
authors.initials: C
authors.lastname: Birkinshaw
authors.forename: Mamisoa N
authors.initials: MN
authors.lastname: Andrianjafy
authors.forename: Rabodo
authors.initials: R
authors.lastname: Andriantsiferana
authors.forename: Vincent E
authors.initials: VE
authors.lastname: Rasamison
authors.forename: Karen
authors.initials: K
authors.lastname: TenDyke
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Shen
authors.forename: Edward M
authors.initials: EM
authors.lastname: Suh
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D005260:Female; D005638:Fruit; D006801:Humans; D020128:Inhibitory Concentration 50; D008270:Madagascar; D015394:Molecular Structure; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018515:Plant Leaves; D043982:Rhizophoraceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014315:Triterpenes; C552300:dihydroxy-8,24E-euphadien-11-one; C552299:tetrahydroxy-7,24E-euphadiene