title: 3-year follow-up of 100 consecutive coronary bifurcation lesions treated with Taxus stents and the crush technique.
abstract: OBJECTIVE
  To determine the 3 year safety and efficacy of crush-stenting with paclitaxel-eluting stents.
  
  
  BACKGROUND
  The optimum two-stent strategy for treatment of coronary bifurcation lesions is undetermined. Crush-stenting is advocated to minimize restenosis through complete circumferential stent coverage; long-term follow-up data are lacking.
  
  
  RESULTS
  In a single center prospective registry, 100 consecutive patients with bifurcation lesions were treated with the Crush technique. The vast majority (93%) were true bifurcations, predominantly involving the left anterior descending and diagonal arteries. Technical success was 98%. Final kissing balloon dilatation, which became standard practice during the study, was attempted in 68 patients and successful in 51. Abciximab was used in all cases. There were no peri-procedural stent thromboses. Follow-up was 100% at 3 years. Symptom-driven target lesion revascularisation was 8% at 3 years. Cumulative 3-year major adverse cardiac events was 28% (7 cardiac deaths, 15 myocardial infarctions, 11 target vessel revascularisations). Absence of a final kissing inflation predicted repeat revascularisation but not death, infarction or stent thrombosis. Three probable stent thromboses occurred, of which two were very late.
  
  
  CONCLUSIONS
  Where a two-stent bifurcation strategy is required, Crush-stenting with paclitaxel-eluting stents is safe and effective in the long-term. Failure to perform a final kissing dilatation increases the likelihood of revascularisation but not other adverse events.
authors.affiliation: Department of Cardiovascular Medicine, University of Birmingham, Birmingham, United Kingdom.
authors.forename: Colin D
authors.initials: CD
authors.lastname: Chue
authors.forename: Helen C
authors.initials: HC
authors.lastname: Routledge
authors.forename: Peter F
authors.initials: PF
authors.lastname: Ludman
authors.forename: Jonathan N
authors.initials: JN
authors.lastname: Townend
authors.forename: Andrew C R
authors.initials: AC
authors.lastname: Epstein
authors.forename: Nigel P
authors.initials: NP
authors.lastname: Buller
authors.forename: Sagar N
authors.initials: SN
authors.lastname: Doshi
mesh_terms: D000077284:Abciximab; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods / Q000401:mortality; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D016009:Chi-Square Distribution; D003324:Coronary Artery Disease / Q000401:mortality / Q000628:therapy*; D018572:Disease-Free Survival; D054855:Drug-Eluting Stents; D004739:England; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000517:prevention & control; D017239:Paclitaxel / Q000008:administration & dosage*; D018579:Patient Selection; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011446:Prospective Studies; D011474:Prosthesis Design; D012042:Registries; D018570:Risk Assessment; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D002317:Cardiovascular Agents; D007140:Immunoglobulin Fab Fragments; D010975:Platelet Aggregation Inhibitors; D017239:Paclitaxel; D000077284:Abciximab