Green chemistry: a facile synthesis of polyfunctionally substituted thieno[3,4-c]pyridinones and thieno[3,4-d]pyridazinones under neat reaction conditions.
A facile, solvent free, ecofriendly approach for the synthesis of pyridine-2,6-diones 4a-d, pyridazinone derivatives 8a-c and thienoazines 6 and 9 is herein described employing neat reaction conditions under both microwave and ultrasound irradiations. This solventless methodology is environmentally benign as it completely eliminates the use of solvent from the reaction procedure.
Al-Zaydi
Khadijah M
KM
Department of Chemistry, Girls' College of Education, King Abduls-Aziz University, Jeddah, P.O. Box 50918, Jeddah 21533, Saudi Arabia. Alzaydi_kh@yahoo.com
Borik
Rita M
RM
Mekheimer
Ramadan A
RA
Elnagdi
Mohamed H
MH
D055772:Green Chemistry Technology / Q000379:methods*; D011728:Pyridones / Q000737:chemistry* / Q000528:radiation effects*; D013010:Sonication
D011728:Pyridones