title: Comparative structural and hemodynamic analysis of vascular trees.
abstract: The availability of detailed three-dimensional images of vascular trees from mammalian organs provides a wealth of essential data for understanding the processes and mechanisms of vascular patterning. Using this detailed geometric data requires the ability to compare individual representations of vascular trees in statistically meaningful ways. This article provides some comparisons of geometry and also of simulated hemodynamics, enabling the identification of similarities and differences among 10 individual specimens (5 placenta specimens and 5 lung specimens). Similar comparisons made with a series of models (starting with the simplest and increasing in complexity) enable the identification of essential features that are needed to account for the patterns and function of vascular arborization.
authors.affiliation: Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: L X
authors.initials: LX
authors.lastname: Yu
authors.forename: M Y
authors.initials: MY
authors.lastname: Rennie
authors.forename: J G
authors.initials: JG
authors.lastname: Sled
authors.forename: R M
authors.initials: RM
authors.lastname: Henkelman
mesh_terms: D000818:Animals; D005260:Female; D005333:Fetus / Q000098:blood supply; D006439:Hemodynamics / Q000502:physiology*; D008168:Lung / Q000098:blood supply* / Q000196:embryology; D051379:Mice; D008815:Mice, Inbred Strains; D008953:Models, Anatomic; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D012039:Regional Blood Flow / Q000502:physiology