Archaebacterial tetraetherlipid liposomes.
Liposomes are widely investigated for their applicability as drug delivery systems. However, the unstable liposomal constitution is one of the greatest limitations, because the liposomes undergo fast elimination after application to the human body. In the presented study, novel archeal lipids were used to prepare liposomal formulations which were tested for their stability at elevated temperatures, at different pH-values and after heat sterilization.
Ozcetin
Aybike
A
Department of Pharmaceutical Technology and Biopharmacy, Philipps-Universität Marburg, Marburg, Germany.
Mutlu
Samet
S
Bakowsky
Udo
U
D004075:Diglycerides / Q000737:chemistry* / Q000302:isolation & purification; D006017:Glycolipids / Q000737:chemistry* / Q000302:isolation & purification; D006863:Hydrogen-Ion Concentration; D008081:Liposomes / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D015394:Molecular Structure; D016945:Sulfolobus acidocaldarius / Q000737:chemistry*; D013696:Temperature
D004075:Diglycerides; D006017:Glycolipids; D008081:Liposomes; C094613:calditoglycerocaldarchaeol