The stripe of primary lateral sclerosis: focal primary motor cortex hypometabolism seen on fluorodeoxyglucose F18 positron emission tomography.
BACKGROUND
Primary lateral sclerosis (PLS) is a progressive upper motor neuron neurodegenerative condition. The diagnosis is made using clinical history, objective neurological assessment, and exclusion of other neurodegenerative disorders.


OBJECTIVE
To evaluate the role of fluorodeoxyglucose F18 positron emission tomography and 3-dimensional stereotactic surface projection in the diagnosis of PLS.


METHODS
Case series.


METHODS
Outpatient neurology clinic. Patients Three cases of probable PLS. Intervention Fluorodeoxyglucose F18 positron emission tomography in 3 patients with PLS.


RESULTS
Three patients (2 male and 1 female; mean age, 65 years) were identified with a clinical diagnosis of PLS. Fluorodeoxyglucose F18 positron emission tomography demonstrated varying degrees of primary motor cortex hypometabolism.


CONCLUSIONS
Fluorodeoxyglucose F18 positron emission tomography and 3-dimensional stereotactic surface projection provide a useful diagnostic method to support a clinical diagnosis of PLS.
Claassen
Daniel O
DO
Departments of Neurology, Mayo Clinic and Mayo College of Medicine, Rochester, Minnesota 55905, USA.
Josephs
Keith A
KA
Peller
Patrick J
PJ
D000368:Aged; D001931:Brain Mapping / Q000379:methods; D003937:Diagnosis, Differential; D018450:Disease Progression; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D020233:Gait Disorders, Neurologic / Q000209:etiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D016472:Motor Neuron Disease / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D010291:Paresis / Q000209:etiology; D049268:Positron-Emission Tomography / Q000379:methods*; D011237:Predictive Value of Tests; D020828:Pseudobulbar Palsy / Q000209:etiology; D011712:Pyramidal Tracts / Q000378:metabolism / Q000503:physiopathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
D019788:Fluorodeoxyglucose F18