Mediators of ocular angiogenesis.
Angiogenesis is the formation of new blood vessels from pre-existing vasculature. Pathologic angiogenesis in the eye can lead to severe visual impairment. In our review, we discuss the roles of both pro-angiogenic and anti-angiogenic molecular players in corneal angiogenesis, proliferative diabetic retinopathy, exudative macular degeneration and retinopathy of prematurity, highlighting novel targets that have emerged over the past decade.
Qazi
Yureeda
Y
Department of Ophthalmology, John Moran Eye Center, University of Utah, Salt Lake City, UT-84132, USA.
Maddula
Surekha
S
Ambati
Balamurali K
BK
D000818:Animals; D016510:Corneal Neovascularization / Q000235:genetics* / Q000378:metabolism; D005123:Eye / Q000098:blood supply*; D016222:Fibroblast Growth Factor 2 / Q000235:genetics / Q000378:metabolism; D006801:Humans; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic; D015861:Retinal Neovascularization / Q000235:genetics* / Q000378:metabolism; D012171:Retinal Vessels / Q000254:growth & development / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; D020782:Matrix Metalloproteinases