TRRAP and the maintenance of stemness in gliomas.
Resistance of brain tumors to therapy and their eventual recurrence is attributed to stem-like cells. In this issue of Cell Stem Cell, a high-throughput kinome-wide screen (Wurdak et al., 2010) has identified TRRAP, a kinase-related protein, as being required for stem cell character in gliomas.
Charles
Nikki A
NA
Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Holland
Eric C
EC