Alcohol consumption and sudden unexpected death in epilepsy: experimental approach.
Using the pilocarpine model of epilepsy, we investigated the effects of alcohol consumption on the frequency of seizures in animals with epilepsy as well the underlying a possible association between alcohol intake and sudden unexpected death in epilepsy (SUDEP) occurrence. Rats were divided randomly into two groups: (A) rats with epilepsy and (B) rats with epilepsy that received a daily dose of ethanol solution (350 mg kg(-1), i.p.) for 30 days. The basal frequency of seizures observed in the A and B groups during the first 30 days were 3.4+/-1.5 and 3.2+/-1.9 seizures per week per animal, respectively. In B group, it was observed a significant seizure increase (11.6+/-5.3) during the first 2 weeks of alcohol administration and quite interesting, one rat died suddenly after a generalized tonic-clonic seizure during this period. We concluded in our experimental study that exist a possible association between alcohol abuse and SUDEP occurrence.
Scorzai
Carla A
CA
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Cysneiros
Roberta M
RM
Arida
Ricardo M
RM
Terra
Vera C
VC
Machado
Hélio R
HR
de Almeida
Antonio-Carlos G
AC
Cavalheiro
Esper A
EA
Scorza
Fulvio A
FA
D000428:Alcohol Drinking / Q000009:adverse effects* / Q000503:physiopathology; D000818:Animals; D003645:Death, Sudden / Q000209:etiology*; D004195:Disease Models, Animal; D004827:Epilepsy / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D018721:Muscarinic Agonists; D010862:Pilocarpine; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors
D018721:Muscarinic Agonists; D010862:Pilocarpine