MK2 signaling: lessons on tissue specificity in modulation of inflammation.
MK2 is a promising candidate for treating inflammation. Mice deficient in MK2 were studied in models of inflammation to see whether MK2 could be a useful target in inflammatory skin disease. Surprisingly, MK2 played only a minor role in skin inflammation, indicating that modulation of cell signaling gives different results depending on the models of inflammation and target organs that are studied.
Fyhrquist
Nanna
N
Unit of Excellence in Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland.
Matikainen
Sampsa
S
Lauerma
Antti
A
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D012867:Skin / Q000378:metabolism*; D012879:Skin Physiological Phenomena; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism; D000099190:MAP-Kinase-Activated Kinase 2
D047908:Intracellular Signaling Peptides and Proteins; D017346:Protein Serine-Threonine Kinases; D048051:p38 Mitogen-Activated Protein Kinases; D000099190:MAP-Kinase-Activated Kinase 2