title: Efficacy of combined porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae vaccination in piglets.
abstract: Three vaccination challenge studies were performed to evaluate the impact on vaccine efficacy of combining porcine reproductive and respiratory syndrome virus (PRRSV) and Mycoplasma hyopneumoniae vaccines. Piglets were vaccinated with either a M hyopneumoniae bacterin, a modified live PRRSV vaccine based on a European-type PRRSV strain, or a combination of both vaccines, followed by experimental infection with either M hyopneumoniae or PRRSV. Vaccine efficacy was evaluated by assessing lung lesion scores for M hyopneumoniae and measuring viraemia for PRRSV. There were no significant differences between the protective efficacy of the combined vaccine protocol and the protective efficacy of the two single vaccines, indicating that PRRSV vaccination did not interfere with M hyopneumoniae vaccine efficacy and vice versa.
authors.affiliation: Intervet/Schering-Plough Animal Health, 5830 AA Boxmeer, The Netherlands. christa.drexler@intervet.com
authors.forename: C S
authors.initials: CS
authors.lastname: Drexler
authors.forename: M H
authors.initials: MH
authors.lastname: Witvliet
authors.forename: M
authors.initials: M
authors.lastname: Raes
authors.forename: M
authors.initials: M
authors.lastname: van de Laar
authors.forename: A A S
authors.initials: AA
authors.lastname: Eggen
authors.forename: E L
authors.initials: EL
authors.lastname: Thacker
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D045705:Mycoplasma hyopneumoniae / Q000276:immunology*; D045729:Pneumonia of Swine, Mycoplasmal / Q000517:prevention & control*; D019318:Porcine Reproductive and Respiratory Syndrome / Q000517:prevention & control*; D019316:Porcine respiratory and reproductive syndrome virus / Q000276:immunology*; D011897:Random Allocation; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D016896:Treatment Outcome; D014613:Vaccines, Attenuated; D017778:Vaccines, Combined; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated; D017778:Vaccines, Combined; D014765:Viral Vaccines