title: The emerging role of lysine acetylation of non-nuclear proteins.
abstract: Lysine acetylation is a post-translational modification that critically regulates gene transcription by targeting histones as well as a variety of transcription factors in the nucleus. More recent reports have also demonstrated that numerous proteins located outside the nucleus are also acetylated and that this modification has profound consequences on their functions. This review describes the latest findings on the substrates acetylated outside the nucleus and on the acetylases and deacetylates that catalyse these modifications. Protein acetylation is emerging as a major mechanism by which key proteins are regulated in many physiological processes such as migration, metabolism and aging as well as in pathological circumstances such as cancer and neurodegenerative disorders.
authors.affiliation: Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, CHU Sart-Tilman, Liège, Belgium.
authors.forename: Pierre
authors.initials: P
authors.lastname: Close
authors.forename: Catherine
authors.initials: C
authors.lastname: Creppe
authors.forename: Magali
authors.initials: M
authors.lastname: Gillard
authors.forename: Aurélie
authors.initials: A
authors.lastname: Ladang
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Chapelle
authors.forename: Laurent
authors.initials: L
authors.lastname: Nguyen
authors.forename: Alain
authors.initials: A
authors.lastname: Chariot
mesh_terms: D000107:Acetylation; D000818:Animals; D006801:Humans; D008239:Lysine / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism*
chemical_list: D011506:Proteins; D008239:Lysine