title: Enzyme-instructed self-assembly of peptide derivatives to form nanofibers and hydrogels.
abstract: The review describes the use of enzyme catalysis and self-assembly, two essential and ubiquitous processes in biology, to create molecular nanofibers of peptide derivatives at the supramolecular level as potential nanomedicines and biomaterials. In particular, we discuss the use of enzymes to instruct the self-assembly of small peptide derivatives for hydrogelation, which takes place in vitro or in vivo, extra- or intracellularly, as a new strategy to detect the activity of enzymes, screen enzyme inhibitors, type bacteria, develop drug delivery systems, enhance the activity and stability of enzymes, and control the fate of cells.
authors.affiliation: Department of Chemistry, Brandeis University, 415 South St, Waltham, MA 02454, USA.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.forename: Zhimou
authors.initials: Z
authors.lastname: Yang
authors.forename: Yi
authors.initials: Y
authors.lastname: Kuang
authors.forename: Man-Lung
authors.initials: ML
authors.lastname: Ma
authors.forename: Jiayang
authors.initials: J
authors.lastname: Li
authors.forename: Fan
authors.initials: F
authors.lastname: Zhao
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism; D004795:Enzyme Stability; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D015394:Molecular Structure; D057139:Nanofibers / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D015202:Protein Engineering; D014867:Water / Q000737:chemistry
chemical_list: D004798:Enzymes; D020100:Hydrogels; D010455:Peptides; D014867:Water