title: [Orbital territory hyperperfusion in pregnant women with systemic lupus erythematosus].
abstract: OBJECTIVE
  to analyze the ophthalmic artery functioning in pregnant women with systemic lupus erythematosus (PL) without active renal disease as compared to non-pregnant women with lupus (NPL) without active renal disease, and to normal pregnant women (PN).
  
  
  METHODS
  observational study that analyzed ophthalmic artery dopplervelocimetric variables of 20 PN, 10 PL and 17 NPL women. The variables analyzed were: pulsatility index (PI), final diastolic velocity (FDV) and velocity peak ratio (VPR). Mean and standard deviation of these indexes were calculated. For group mean comparison, analysis of variance (ANOVA) and the post-hoc Tukey test have been used, with confidence interval of 95% (p<0.05).
  
  
  RESULTS
  the PN group showed the following means and standard deviations of ophthalmic artery parameters: PI=2,4+/-0,3; VPR=0,5+/-0,1 e FDV=5,1+/-2,1 cm/s. The PL and NPL groups showed the following values, respectively: PI=2,0+/-0,4 and 1,9+/-0,4; VPR=0,6+/-0,1 and 0,6+/-0,1; FDV=9,7+/-3,9 cm/s and 8,1+/-4,3 cm/s. There was not significant mean difference between the PL and NPL groups for PI, VPR or FDV. However, statistically significant mean differences were observed between PN and PL for PI, VPR and FDV, with higher values of FDV and VPR in the PL group.
  
  
  CONCLUSIONS
  there was a reduction of ophthalmic artery vascular impedance with orbital hyperfusion in the two groups of women with lupus erythematosus as compared to normal pregnant women. These results may help to improve the understanding on pathophysiology of systemic lupus erythematosus. In addition, the present method may be applied in future studies as a complementary procedure for the differential diagnosis between pre-eclampsia and renal failure due to lupus.
authors.affiliation: Universidade Federal de Uberlândia, Uberlândia, MG, Brasil. mairesfreitas@yahoo.com.br
authors.forename: Márcia Aires Rodrigues
authors.initials: MA
authors.lastname: de Freitas
authors.forename: Angélica Lemos Debs
authors.initials: AL
authors.lastname: Diniz
authors.forename: Maria Célia
authors.initials: MC
authors.lastname: Dos Santos
authors.forename: Ben Hur Braga
authors.initials: BH
authors.lastname: Taliberti
authors.forename: Roberto
authors.initials: R
authors.lastname: Ranza
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology*; D009880:Ophthalmic Artery / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*