Efficacy of antibiotic-impregnated external ventricular drain catheters.
We prospectively compared the incidence of ventriculitis associated with external ventricular drains (EVD) impregnated with clindamycin and rifampicin with historical controls. We found the use of antibiotic impregnated (AI) EVDs showed a significant decrease in positive cerebrospinal fluid cultures and a significant delay in time to EVD infection.
Muttaiyah
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S
Department of Microbiology, Auckland City Hospital, Private Bag 92024, Grafton, Auckland 1023, New Zealand.
Ritchie
S
S
John
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S
Mee
E
E
Roberts
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S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis; D002408:Catheters, Indwelling / Q000009:adverse effects* / Q000382:microbiology; D002494:Central Nervous System Infections / Q000134:cerebrospinal fluid / Q000209:etiology / Q000601:surgery; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects* / Q000379:methods; D002648:Child; D002675:Child, Preschool; D002981:Clindamycin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019586:Intracranial Hypertension / Q000209:etiology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012293:Rifampin / Q000008:administration & dosage; D055815:Young Adult
D000891:Anti-Infective Agents, Local; D002981:Clindamycin; D012293:Rifampin