Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice.
PRE-084, a selective sigma receptor agonist, exhibited an antidepressant-like effect in the forced swim test (FST) in Albino Swiss and C57BL/6J mice. This effect was counteracted by BD 1047 (5 and 10 mg/kg) but not by SM-21 (3 and 10 mg/kg), which are sigma(1)- and sigma(2)-receptor antagonists, respectively. The results indicated that PRE-084 has an antidepressant-like effect in C57BL/6J and, to a lesser extent, in Albino Swiss mice. These results support the idea that sigma(1)-receptors, but not sigma(2)-receptors, contribute to the mechanism of antidepressant activity of sigma agonists in FST.
Skuza
Grazyna
G
Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Kraków, Poland. skuza@if-pan.krakow.pl
Rogóz
Zofia
Z
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002087:Butyrates / Q000008:administration & dosage / Q000494:pharmacology; D003863:Depression / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D005029:Ethylenediamines / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009025:Morpholines / Q000494:pharmacology*; D017480:Receptors, sigma / Q000819:agonists* / Q000187:drug effects / Q000378:metabolism; D013045:Species Specificity; D013550:Swimming; D014326:Tropanes / Q000008:administration & dosage / Q000494:pharmacology; D000097605:Sigma-1 Receptor
D000928:Antidepressive Agents; D002087:Butyrates; D005029:Ethylenediamines; D009025:Morpholines; D017480:Receptors, sigma; D014326:Tropanes; D000097605:Sigma-1 Receptor; C106107:sigma-2 receptor; C071738:2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate; C107044:SM 21; C097963:N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin