title: [Progress toward molecular determinants of the pathogenesis of disease due to nontypeable Haemophilus influenzae].
abstract: Haemophilus influenzae (Hi) is a pathogen exclusively found in humans. It causes a wide range of infections from the upper respiratory tract to serious invasive diseases. Such as pneumonia, septicemia and meningitis. Strains of Hi are usually classified into six serotypes a to f and nontypeable H. influenzae (NTHI) according to the antigenicities and compositions of their polysaccharide capsules. Hib was a common cause of serious infections in younger children. The polysaccharide-protein conjugate vaccines against Hib had almost eliminated H. influenzae as a cause of pediatric meningitis. However, NTHI remains an important pathogen, particularly in children and the elderly. Efforts to understand and control NTHI disease have been hampered by the diversity of these bacteria. This review introduced the study progress about pathogenic mechanism of NTHI. In order to provide the help for development of vaccine, clinic treatment and prevent the occurrence of diseases causing by NTHI.
authors.affiliation: National Institute for Communicable Disease Control and Prevention, Chinese Center for Diseases Control and Prevention, Beijing 102206, China.
authors.forename: Guo-Zhong
authors.initials: GZ
authors.lastname: Tian
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhu-Jun
authors.initials: ZJ
authors.lastname: Shao
mesh_terms: D000818:Animals; D006192:Haemophilus Infections / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D006193:Haemophilus influenzae / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D054884:Host-Pathogen Interactions; D006801:Humans
chemical_list: D018073:Haemophilus Vaccines