title: MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2.
abstract: Accumulating evidence suggests small non-coding RNAs (microRNAs) play important roles in human cancer progression. In the present study, we found miR-150 was overexpressed in gastric cancer cell lines and tissues. Ectopic expression of miR-150 promoted tumorigenesis and proliferation of gastric cancer cells. Luciferase reporter assay demonstrated that EGR2 was a direct target of miR-150. Collectively, our study demonstrated that overexpression of miR-150 in gastric cancer could promote proliferation and growth of cancer cells at least partially through directly targeting the tumor-suppressor EGR2, suggesting a potential strategy for the development of miRNA-based treatment of gastric cancer.
authors.affiliation: Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.forename: Haifeng
authors.initials: H
authors.lastname: Jin
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Yang
authors.forename: Guanhong
authors.initials: G
authors.lastname: Luo
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Lu
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.forename: Gui
authors.initials: G
authors.lastname: Ren
authors.forename: Tao
authors.initials: T
authors.lastname: Su
authors.forename: Yan
authors.initials: Y
authors.lastname: Pan
authors.forename: Bin
authors.initials: B
authors.lastname: Feng
authors.forename: Zengfu
authors.initials: Z
authors.lastname: Xue
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Daiming
authors.initials: D
authors.lastname: Fan
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D001483:Base Sequence; D002277:Carcinoma / Q000235:genetics / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D051767:Early Growth Response Protein 2 / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology*
chemical_list: D051767:Early Growth Response Protein 2; D035683:MicroRNAs; C497326:EGR2 protein, human; C533097:MIR150, human