Aire, master of many trades.
In thymic epithelial cells, the protein Aire (autoimmune regulator) induces the ectopic expression of hundreds of peripheral tissue antigens, thus enlarging the repertoire of antigens available for the induction of central T cell tolerance. By analyzing Aire's interacting partners, Abramson et al. (2010) shed new light on this unorthodox form of gene expression.
Kyewski
Bruno
B
Division of Developmental Immunology, Tumor Immunology Program, German Cancer Research Center, Heidelberg 69120, Germany. b.kyewski@dkfz.de
Peterson
Pärt
P
D000818:Animals; D001324:Autoantigens / Q000235:genetics* / Q000276:immunology; D002460:Cell Line; D005786:Gene Expression Regulation; D006801:Humans; D007108:Immune Tolerance; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology*; D014157:Transcription Factors / Q000378:metabolism*; D000096927:AIRE Protein
D001324:Autoantigens; D014157:Transcription Factors; D000096927:AIRE Protein