title: The senescence-associated secretory phenotype: the dark side of tumor suppression.
abstract: Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretory phenotype (SASP) that turns senescent fibroblasts into proinflammatory cells that have the ability to promote tumor progression.
authors.affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Coppé
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Desprez
authors.forename: Ana
authors.initials: A
authors.lastname: Krtolica
authors.forename: Judith
authors.initials: J
authors.lastname: Campisi
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000473:pathology; D016922:Cellular Senescence / Q000502:physiology; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D009369:Neoplasms / Q000473:pathology* / Q000503:physiopathology; D010641:Phenotype; D025521:Tumor Suppressor Proteins / Q000502:physiology
chemical_list: D025521:Tumor Suppressor Proteins