Transmyocardial laser revascularization combined with intramyocardial endothelial progenitor cell transplantation in patients with intractable ischemic heart disease ineligible for conventional revascularization: preliminary results in a highly selected small patient cohort.
OBJECTIVE
Transmyocardial laser revascularization for angina relief and intramyocardial autologous endothelial progenitor cell injection for neoangiogenesis may offer a new treatment strategy for patients with intractable ischemic heart disease.


METHODS
Transmyocardial laser revascularization and intramyocardial injection of bone marrow-derived CD133+ cells was performed in six highly symptomatic patients. Transmyocardial laser channels were created and isolated CD133+ cells were injected intramyocardially. All patients were followed up for a minimum of 6 months postoperatively.


RESULTS
One patient died shortly after the operation due to refractory heart failure. In the five survivors, CCS class improved as well as left ventricular ejection fraction. Left ventricular end-diastolic volume and myocardial perfusion varied between the patients. All patients described a considerable improvement in quality of life postoperatively. Repeated 24-hour Holter monitoring revealed no significant arrhythmias.


CONCLUSIONS
In this small patient cohort, intramyocardial CD 133+ cell injection combined with transmyocardial laser revascularization led to an improvement in clinical symptomatology in all patients and in left ventricular function in 4 out of 5 patients, with an unclear effect on myocardial perfusion. Caution is advised when employing this therapy in patients with severely depressed left ventricular function.
Babin-Ebell
J
J
Cardiac and Thoracic Vascular Surgery Clinic, University of Luebeck, Luebeck, Germany.
Sievers
H-H
HH
Charitos
E I
EI
Klein
H M
HM
Jung
F
F
Hellberg
A-K
AK
Depping
R
R
Sier
H A
HA
Marxsen
J
J
Stoelting
S
S
Kraatz
E G
EG
Wagner
K F
KF
D000368:Aged; D003131:Combined Modality Therapy; D042783:Endothelial Cells / Q000637:transplantation*; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000601:surgery*; D009204:Myocardial Revascularization / Q000379:methods*; D033581:Stem Cell Transplantation; D013234:Stem Cells; D016896:Treatment Outcome