A new map to understand deubiquitination.
Deubiquitination is a crucial mechanism in ubiquitin-mediated signalling networks. The importance of Dubs (deubiquitinating enzymes) as regulators of diverse cellular processes is becoming ever clearer as new roles are elucidated and new pathways are shown to be affected by this mechanism. Recent work, reviewed in the present paper, provides new perspective on the widening influence of Dubs and a new tool to focus studies of not only Dub interactions, but also potentially many more cellular systems.
Katz
Elijah J
EJ
Institut de Biologia Molecular de Barcelona, CSIC, Barcelona Scientific Park, Baldiri i Reixac 15-21, 08028 Barcelona, Spain.
Isasa
Marta
M
Crosas
Bernat
B
D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D015203:Reproducibility of Results; D015398:Signal Transduction / Q000502:physiology*; D025801:Ubiquitin / Q000378:metabolism*; D043222:Ubiquitin Thiolesterase / Q000235:genetics / Q000378:metabolism
D025801:Ubiquitin; D010450:Endopeptidases; D043222:Ubiquitin Thiolesterase