title: Renal failure due to combined cast nephropathy, amyloidosis and light-chain deposition disease.
abstract: Renal dysfunction commonly occurs in multiple myeloma (MM) and is caused by deposition of abnormal light chain within various compartments of the kidney. Renal pathologic findings are diverse and include cast nephropathy (CN), amyloidosis and light-chain deposition disease (LCDD). We report a case of renal failure in a patient with MM caused by concurrent CN, amyloidosis and LCDD which has not been previously described.
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Lorenz
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Sethi
authors.forename: Tanya L
authors.initials: TL
authors.lastname: Poshusta
authors.forename: Marina
authors.initials: M
authors.lastname: Ramirez-Alvarado
authors.forename: Shaji
authors.initials: S
authors.lastname: Kumar
authors.forename: Donna J
authors.initials: DJ
authors.lastname: Lager
authors.forename: Fernando C
authors.initials: FC
authors.lastname: Fervenza
authors.forename: Nelson
authors.initials: N
authors.lastname: Leung
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000150:complications*; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007147:Immunoglobulin Light Chains; D007674:Kidney Diseases / Q000150:complications*; D009101:Multiple Myeloma / Q000150:complications*; D051437:Renal Insufficiency / Q000209:etiology* / Q000628:therapy
chemical_list: D007147:Immunoglobulin Light Chains