[Change from inflammation to carcinoma in ulcerative colitis: the role of PTEN/PI3K/AKT].
OBJECTIVE
To detect the changes of expression of PTEN protein and AKT protein in patients with Ulcerative Colitis (UC) in the pathway from inflammation to carcinoma.


METHODS
A total of 110 paraffin colorectal sections were examined, which included 65 cases with UC, 25 cases with colorectal cancer and 25 cases with normal tissues. The expression of PTEN protein and AKT protein was detected with immunohistochemistry.


RESULTS
(1) The patients with UC had lower expression of PTEN protein and higher expression of AKT than those with normal tissues (P < 0.01). (2) The patients with UC had higher expression of PTEN protein and lower expression of AKT protein than those with colorectal cancer (P < 0.01). (3) With the progress of UC, the expression of PTEN protein decreased while the expression of AKT protein increased (P < 0.01). (4) The expression of PTEN protein was negatively correlated with the expression with AKT protein in patients with UC and colorectal cancer (r = -0. 542 and -0. 674, respectively P < 0.01).


CONCLUSIONS
The change of expressions of PTEN protein and AKT protein might play an important role in the development of UC and colorectal cancer. Decreased PTEN protein and increased AKT protein might be a marker for the early detection of the occurrence of colorectal cancer in patients with UC.
Fu
Dai-Gang
DG
Department of Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.
Huang
Xiao-Li
XL
Gan
Hua-Tian
HT
Zhang
De-Kui
DK
Zhao
Li-Qiang
LQ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D003093:Colitis, Ulcerative / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D055815:Young Adult
D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human