Gold- and platinum-catalyzed formal Markownikoff's double hydroamination of alkynes: a rapid access to tetrahydroquinazolinones and angularly-fused analogues thereof.
A highly efficient gold(I)- and platinum(II)-catalyzed process for formal Markownikoff's double hydroamination of alkynes tethered with hydroxyl group has been developed. The method was shown to be applicable to a broad range of 2-aminobenzamides and alkynols leading to the formation of multiply substituted tetrahydroquinazolinones. Interestingly, when Pt(IV)Cl(4) catalyst was employed, cyclic angularly fused compound was obtained.
Patil
Nitin T
NT
Organic Chemistry Division II, Indian Institute of Chemical Technology, Hyderabad 500 607, India. patilnitint@yahoo.com
Kavthe
Rahul D
RD
Raut
Vivek S
VS
Shinde
Valmik S
VS
Sridhar
Balasubramanian
B