title: Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.
abstract: The major mood disorders, which include bipolar disorder and major depressive disorder (MDD), are considered heritable traits, although previous genetic association studies have had limited success in robustly identifying risk loci. We performed a meta-analysis of five case-control cohorts for major mood disorder, including over 13,600 individuals genotyped on high-density SNP arrays. We identified SNPs at 3p21.1 associated with major mood disorders (rs2251219, P = 3.63 x 10(-8); odds ratio = 0.87; 95% confidence interval, 0.83-0.92), with supportive evidence for association observed in two out of three independent replication cohorts. These results provide an example of a shared genetic susceptibility locus for bipolar disorder and MDD.
authors.affiliation: Unit on the Genetic Basis of Mood & Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. mcmahonf@mail.nih.gov
authors.forename: Francis J
authors.initials: FJ
authors.lastname: McMahon
authors.forename: Nirmala
authors.initials: N
authors.lastname: Akula
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Schulze
authors.forename: Pierandrea
authors.initials: P
authors.lastname: Muglia
authors.forename: Federica
authors.initials: F
authors.lastname: Tozzi
authors.forename: Sevilla D
authors.initials: SD
authors.lastname: Detera-Wadleigh
authors.forename: C J M
authors.initials: CJ
authors.lastname: Steele
authors.forename: René
authors.initials: R
authors.lastname: Breuer
authors.forename: Jana
authors.initials: J
authors.lastname: Strohmaier
authors.forename: Jens R
authors.initials: JR
authors.lastname: Wendland
authors.forename: Manuel
authors.initials: M
authors.lastname: Mattheisen
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Mühleisen
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon
authors.forename: Anne
authors.initials: A
authors.lastname: Farmer
authors.forename: John B
authors.initials: JB
authors.lastname: Vincent
authors.forename: Florian
authors.initials: F
authors.lastname: Holsboer
authors.forename: Martin
authors.initials: M
authors.lastname: Preisig
authors.forename: Marcella
authors.initials: M
authors.lastname: Rietschel
mesh_terms: D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D019964:Mood Disorders / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics