title: Polycyclic polyprenylated acylphloroglucinols and chromone O-glucosides from Hypericum henryi subsp. uraloides.
abstract: Two new C(30)-epimeric polycyclic polyprenylated acylphloroglucinols (PPAPs), named uralodins B and C (1 and 2, resp.), were isolated from the aerial parts of Hypericum henryi subsp. uraloides together with two new chromone glucosides, urachromones A and B (3 and 4, resp.), as well as 16 known compounds. Their structures were established by extensive NMR techniques and MS analysis. The epimers 1 and 2 always behaved like a single compound when examined by TLC, and were separated by HPLC. Their configuration was distinguished by comparative analysis of the NMR data with known analogues together with the ROESY experiment. All the isolated PPAPs were evaluated for their cytotoxic activities against HepG2, SGC7901, HL-60, and K562 cell lines. Compound 1 showed modest cytotoxic activities against SGC7901 and HL-60 cell lines, and 2 showed modest cytotoxic activities against HepG2, SGC7901, HL-60, and K562 cell lines.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P R China.
authors.forename: Xuan-Qin
authors.initials: XQ
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Xiao
authors.initials: X
authors.lastname: Cheng
authors.forename: Kou
authors.initials: K
authors.lastname: Wang
authors.forename: Juan
authors.initials: J
authors.lastname: He
authors.forename: Zheng-Hong
authors.initials: ZH
authors.lastname: Pan
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Li
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
mesh_terms: D045744:Cell Line, Tumor; D002867:Chromones / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D018922:HL-60 Cells; D056945:Hep G2 Cells; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D020014:K562 Cells; D008968:Molecular Conformation; D010696:Phloroglucinol / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
chemical_list: D002867:Chromones; D005960:Glucosides; D010696:Phloroglucinol