title: Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene/ruthenium organometallic species.
abstract: Two ethylene linked binuclear mixed ferrocene/ruthenium complexes were biologically investigated in comparison to structurally related mononuclear ferrocene or ruthenium species with styryl substituents or ligands. Results indicated that the electron distribution (but not the redox potential), cellular uptake and (to some minor extent) anti-estrogenic effects were the key contributors to antiproliferative effects observed in tumor cell lines.
authors.affiliation: Institute of Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106 Braunschweig, Germany. ingo.ott@tu-bs.de
authors.forename: Ingo
authors.initials: I
authors.lastname: Ott
authors.forename: Konrad
authors.initials: K
authors.lastname: Kowalski
authors.forename: Ronald
authors.initials: R
authors.lastname: Gust
authors.forename: Jörg
authors.initials: J
authors.lastname: Maurer
authors.forename: Philipp
authors.initials: P
authors.lastname: Mücke
authors.forename: Rainer F
authors.initials: RF
authors.lastname: Winter
mesh_terms: D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005030:Ethylenes / Q000737:chemistry* / Q000494:pharmacology; D005296:Ferrous Compounds / Q000737:chemistry* / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D000075163:Metallocenes; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D005030:Ethylenes; D005296:Ferrous Compounds; D000075163:Metallocenes; D009942:Organometallic Compounds; D012428:Ruthenium; C004998:ferrocene