Increased oxidative stress in patients with pseudoexfoliation syndrome.
OBJECTIVE
The objective of this study was to investigate the antioxidant/oxidant status of serum in patients with pseudoexfoliation syndrome (PEX).


METHODS
Forty-seven patients with PEX and 32 healthy controls were included in the study. Serum total antioxidant capacity (TAC) and total oxidant status (TOS) levels were determined by using a novel automated method.


RESULTS
A significant increase in serum TOS (p < 0.001) and a significant decrease in serum TAC (p < 0.0001) were observed in PEX patients compared to control subjects.


CONCLUSIONS
TAC decreases while the oxidative stress increases in PEX.
Cumurcu
Tongabay
T
Department of Ophthalmology, Gaziosmanpasa University School of Medicine, Tokat, Turkey. tongabay@superonline.com
Gunduz
Abuzer
A
Ozyurt
Huseyin
H
Nurcin
Hatun
H
Atis
Omer
O
Egri
Mucahit
M
D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D017889:Exfoliation Syndrome / Q000097:blood*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress; D011446:Prospective Studies; D014065:Tonometry, Ocular
D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants