title: Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted.
abstract: BACKGROUND
  Dental trauma is common. One of the most severe injuries is when a permanent tooth is knocked completely out (avulsed) of the mouth. In most circumstances the tooth should be replanted as quickly as possible. There is uncertainty on how best to prepare teeth for replantation.
  
  
  OBJECTIVE
  To compare the effects of a range of interventions for managing traumatised permanent teeth with avulsion injuries.
  
  
  METHODS
  The Cochrane Oral Health Group's Trials Register (to 28th October 2009); CENTRAL (The Cochrane Library 2009, Issue 4); MEDLINE (1950 to October 2009); EMBASE (1980 to October 2009); www.clinicaltrials.gov/; www.controlled-trials.com/ and reference lists of articles were searched. There were no language restrictions.
  
  
  METHODS
  Only randomised controlled trials (RCTs), that included a minimum follow-up period of 12 months, for interventions for avulsed and replanted permanent teeth were considered.
  
  
  METHODS
  Two review authors independently extracted data and assessed trial quality and the risk of bias in studies to be included.
  
  
  RESULTS
  Three studies, involving a total of 162 patients and 231 teeth were identified. Study one (with a high risk of bias) investigated the effect of extra-oral endodontics. This showed no significant difference in radiographic resorption compared with intra-oral endodontics provided at week 1 for teeth avulsed for longer than 60 minutes dry time. Study two (which had a moderate risk of bias) investigated a 10-minute soaking in thymosin alpha 1 prior to replantation and then its further use as a daily gingival injection for the first 7 days. They reported a strong benefit at 48 months (14% with periodontal healing in the control group versus 77% for the experimental group). Study three (with a high risk of bias) investigated a 20-minute soaking with gentamycin sulphate (4x10(7) U/L) for both groups prior to replantation and then the use of hyperbaric oxygen daily in the experimental group for 80 minutes for the first 10 days. They reported a strong benefit at 12 months (43% periodontal healing versus 88% for the experimental group). There was no formal reporting of adverse events.
  
  
  CONCLUSIONS
  The available evidence suggests that extra-oral endodontics is not detrimental for teeth replanted after more than 60 minutes dry time. Studies with moderate/high risk of bias indicate that soaking in thymosin alpha 1 and gentamycin sulphate followed by hyperbaric oxygen may be advantageous however, they have not previously been reported as interventions for avulsed teeth and need further validation. More evidence with low risk of bias is required and, with the low incidence of avulsed teeth, collaborative multicentre trials are indicated.
authors.affiliation: Department of Paediatric Dentistry, Leeds Dental Institute, Clarendon Way, Leeds, UK, LS2 9LU.
authors.forename: Peter
authors.initials: P
authors.lastname: Day
authors.forename: Monty
authors.initials: M
authors.lastname: Duggal
mesh_terms: D001846:Bone Development / Q000502:physiology; D006801:Humans; D007180:Incisor / Q000293:injuries*; D010513:Periodontal Ligament / Q000254:growth & development; D011300:Preoperative Care / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D014084:Tooth Avulsion / Q000601:surgery*; D014090:Tooth Replantation / Q000379:methods*