FANCM: A landing pad for the Fanconi Anemia and Bloom's Syndrome complexes.
In this issue of Molecular Cell, Deans and West (2009) reveal the molecular basis of the phenotypic similarities between Fanconi Anemia (FA) and Bloom's Syndrome, identifying FANCM as the anchor for both FA and Bloom's complexes at the site of the DNA interstrand crosslink.
Vinciguerra
Patrizia
P
Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
D'Andrea
Alan D
AD
D001816:Bloom Syndrome / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage; D004265:DNA Helicases / Q000235:genetics / Q000378:metabolism*; D004260:DNA Repair; D005199:Fanconi Anemia / Q000235:genetics / Q000378:metabolism; D006801:Humans; D010641:Phenotype; D053484:RecQ Helicases / Q000235:genetics / Q000378:metabolism
C097151:Bloom syndrome protein; C518295:FANCM protein, human; D004265:DNA Helicases; D053484:RecQ Helicases