title: Nuclear receptors gene polymorphisms and risk of restenosis and clinical events following coronary stenting.
abstract: BACKGROUND
  Hereditary factors connected with inflammation and fibroproliferation may play important role in restenotic process after coronary stenting. Peroxisome proliferator-activated receptors (PPAR) and retinoic X receptors (RXR) regulate the transcription of crucial genes involved in the glucose and lipid metabolism, inflammation and cell differentiation.
  
  
  METHODS
  In our angiographic and clinical study we assessed the association of gene polymorphisms of L162V for PPAR-alpha, C161T for PPAR-gamma and A(39526)AA for RXR-alpha with the risk of restenosis and cardiac events after coronary stenting. Primary endpoint was diameter stenosis > or = 50% at follow-up angiography. Secondary endpoints were death, myocardial infarction and/or target lesion revascularisation at 12 months, and clinical restenosis. The results were adjusted for known predictors of restenosis. The genotypes were analysed by polymerase chains reaction (PCR) and restriction fragment length polymorphism (RFLP) methods.
  
  
  RESULTS
  Control angiography was performed in 477 of 565 patients (84.4%) with following restenosis rates in genotype subgroups: CC 29.0% vs GC/GG 22.6% (p = 0.33) in L162V, CC 29.9% vs TC/TT 24.6% (p = 0.24) in C161T and A/A 26.9% vs A/AA + AA/AA 35.0% (p = 0.14) in A(39526)AA polymorphisms. The T allele ofC161T polymorphism was associated with lower frequency of clinical restenosis (p = 0.015).
  
  
  CONCLUSIONS
  We could not find an association of L162V PPAR-alpha, C161T PPAR-gamma and A(39526)AA RXR-alpha gene polymorphisms with angiographic in-stent restenosis or major cardiac events. However, we found the relationship between C161T PPAR-gamma polymorphism and clinical restenosis deserving further study.
authors.affiliation: Interní kardiologická klinika Lékarské fakulty MU a FN Brno. petr.neug@post.cz
authors.forename: P
authors.initials: P
authors.lastname: Neugebauer
authors.forename: M
authors.initials: M
authors.lastname: Goldbergová-Pávková
authors.forename: P
authors.initials: P
authors.lastname: Kala
authors.forename: O
authors.initials: O
authors.lastname: Bocek
authors.forename: P
authors.initials: P
authors.lastname: Jerábek
authors.forename: M
authors.initials: M
authors.lastname: Poloczek
authors.forename: M
authors.initials: M
authors.lastname: Vytiska
authors.forename: J
authors.initials: J
authors.lastname: Parenica
authors.forename: R
authors.initials: R
authors.lastname: Mikulík
authors.forename: J
authors.initials: J
authors.lastname: Jarkovský
authors.forename: B
authors.initials: B
authors.lastname: Semrád
authors.forename: J
authors.initials: J
authors.lastname: Spinar
authors.forename: A
authors.initials: A
authors.lastname: Vasků
mesh_terms: D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000235:genetics*; D023921:Coronary Stenosis / Q000628:therapy; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics*; D011110:Polymorphism, Genetic; D047490:Retinoid X Receptor alpha / Q000235:genetics*; D012307:Risk Factors; D015607:Stents
chemical_list: D047492:Peroxisome Proliferator-Activated Receptors; D047490:Retinoid X Receptor alpha