title: Rapid determination of nanotoxicity using luminous bacteria.
abstract: A new luminescence-based toxicity test using luminous bacteria as a reporting agent has been developed to determine EC(50) of different nanomaterials, such as gold nanoparticles and carbon nanotubes on living organisms. The whole assay takes only about 15 min and is as sensitive as other standard methods. Due to its technical simplicity, rapidity and sensitivity, this luminescent bacteria test has the potential to be developed as a general test of toxicity for a wide variety of nanomaterials.
authors.affiliation: Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Beibei, Chongqing 400715, P. R. China. zhenghz@swu.edu.cn
authors.forename: Huzhi
authors.initials: H
authors.lastname: Zheng
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Yihui
authors.initials: Y
authors.lastname: Lu
authors.forename: Yijuan
authors.initials: Y
authors.lastname: Long
authors.forename: Lingling
authors.initials: L
authors.lastname: Wang
authors.forename: Kam-Piu
authors.initials: KP
authors.lastname: Ho
authors.forename: Kwok-Yin
authors.initials: KY
authors.lastname: Wong
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D002244:Carbon / Q000633:toxicity; D005434:Flow Cytometry; D006046:Gold / Q000633:toxicity; D007928:Lethal Dose 50; D049449:Luminescence; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000633:toxicity*; D043942:Nanotubes / Q000633:toxicity; D012710:Serum Albumin, Bovine / Q000737:chemistry
chemical_list: D012710:Serum Albumin, Bovine; D002244:Carbon; D006046:Gold