Angiotensin II receptor antagonists against migraine in pregnancy: fatal outcome.
A pregnant young woman with a severe migraine is prescribed candesartan, an angiotensin II type 1 receptor antagonist (AT II antagonists). This has a positive effect-except for severe maldevelopment of her fetus. There is an increase in the use of the fetotoxic drugs, AT II antagonists and angiotensin-converting enzyme inhibitors, as prophylactic treatment of migraines, in addition to their use as hypertensives.
Haaland
Kirsti
K
Department of Pediatrics, Oslo University Hospital, Ullevål, Oslo, Norway. kirsti66@online.no
D000014:Abnormalities, Drug-Induced / Q000473:pathology* / Q000503:physiopathology; D000328:Adult; D047228:Angiotensin II Type 1 Receptor Blockers / Q000009:adverse effects*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects; D001562:Benzimidazoles / Q000009:adverse effects*; D001713:Biphenyl Compounds; D017809:Fatal Outcome; D005260:Female; D005333:Fetus / Q000002:abnormalities / Q000187:drug effects*; D006801:Humans; D007668:Kidney / Q000002:abnormalities / Q000187:drug effects; D008168:Lung / Q000002:abnormalities / Q000187:drug effects; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology / Q000517:prevention & control*; D010920:Placenta / Q000187:drug effects / Q000378:metabolism; D011247:Pregnancy; D012886:Skull / Q000187:drug effects / Q000473:pathology; D013723:Teratogens / Q000494:pharmacology; D013777:Tetrazoles / Q000009:adverse effects*
D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D013723:Teratogens; D013777:Tetrazoles; C081643:candesartan