title: Immunohistochemical expression of HER-2/NEU-CERBB-2 in patients with adenocarcinoma of the stomach.
abstract: OBJECTIVE
  To determine the prevalence of Her-2/Neu-cerbb-2 in the gastric mucosa of patients with gastric adenocarcinoma in a brazilian patient group.
  
  
  METHODS
  The immunohistochemical expression of Her-2/Neu was studied in 37 formalin-fixed paraffin-embedded tissue sections.
  
  
  RESULTS
  The immunohistochemical reaction produced by the anti-HER-2/Neu antibody was positive in two cases (5.4%).
  
  
  CONCLUSIONS
  The low prevalence of Her-2/Neu observed in these southern brazilian cases is probably due to the great number of poorly differentiated cancers in this series.
authors.affiliation: Federal University of Rio Grande do Sul, Porto Alegre, RS, Brasil. bruce@cpovo.net
authors.forename: Fernando K
authors.initials: FK
authors.lastname: Cirne-Lima
authors.forename: Aline de Souza
authors.initials: Ade S
authors.lastname: Rosa
authors.forename: Jane M U
authors.initials: JM
authors.lastname: Kulczynski
authors.forename: Diego S
authors.initials: DS
authors.lastname: Mattana
authors.forename: Kizzy
authors.initials: K
authors.lastname: Corezolla
authors.forename: Luis F
authors.initials: LF
authors.lastname: Moreira
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics*; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000737:chemistry / Q000235:genetics*
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases