Development and evaluation of novel buccoadhesive wafers of nimodipine for treatment of hypertension.
Buccoadhesive wafers (BW) containing Nimodipine (N) were prepared using the solvent casting method. Chitosan lactate was used as the mucoadhesive polymer with different ratios to PVP K-30 in preparation of the sustained release layer. Sodium carboxymethyl cellulose low viscosity (SCMC LV) in different ratios with Eudragit-RS30D was used in preparation of the immediate release layer of (BW). The wafers were tested for their physical characteristics, ex vivo mucoadhesion strength, ex vivo mucoadhesion time, in vitro drug release, and in vitro permeation and in vivo bioavailability studies. Wafers exhibited controlled release for 7 h. The mechanism of drug release was found to be non-Fickian diffusion and followed by first-order kinetics. Thus, BW of N could be an alternative route to bypass the hepatic first-pass metabolism and to improve the bioavailability of N.
Hassan
Nisreen
N
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India.
Ali
Mushir
M
Ali
Javed
J
D000180:Acrylic Resins / Q000008:administration & dosage / Q000493:pharmacokinetics; D000268:Adhesiveness; D000278:Administration, Buccal; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001682:Biological Availability; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry; D004058:Diffusion; D004304:Dosage Forms; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004355:Drug Stability; D005079:Excipients / Q000008:administration & dosage / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D006973:Hypertension / Q000188:drug therapy*; D009061:Mouth Mucosa; D009553:Nimodipine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004364:Pharmaceutical Preparations; D011817:Rabbits; D012995:Solubility; D013678:Technology, Pharmaceutical; D014783:Viscosity
D000180:Acrylic Resins; D000959:Antihypertensive Agents; D004304:Dosage Forms; D004337:Drug Carriers; D005079:Excipients; D004364:Pharmaceutical Preparations; C050528:Eudragit RS; D009553:Nimodipine; D048271:Chitosan; D002266:Carboxymethylcellulose Sodium