title: Changes in quality of life and sexual health are associated with low-dose peginterferon therapy and disease progression in patients with chronic hepatitis C.
abstract: BACKGROUND
  Primary analysis of the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis (HALT-C) Trial showed long-term peginterferon therapy did not reduce complications in patients with chronic hepatitis C and advanced fibrosis or cirrhosis.
  
  
  OBJECTIVE
  To assess the effects of long-term peginterferon therapy and disease progression on health-related quality of life (HRQOL), symptoms and sexual health in HALT-C patients.
  
  
  METHODS
  A total of 517 HALT-C patients received peginterferon alfa-2a (90 microg/week); 532 received no additional treatment for 3.5 years. Patients were followed up for outcomes of death, hepatocellular carcinoma and hepatic decompensation. Sexual health, SF-36 scores and symptoms were serially assessed by repeated-measures analyses of covariance.
  
  
  RESULTS
  Patients with cirrhosis (n = 427) reported lower general well-being and more fatigue (P < 0.001) than patients with fibrosis (n = 622). Physical scores declined significantly over time, independent of treatment, and patients with cirrhosis reported lower scores. Vitality scores were lower in those with cirrhosis, and treated patients experienced a greater decline over time than untreated patients; HRQOL rebounded after treatment ended. Patients with a clinical outcome had significantly greater declines in all SF-36 and symptom scores. Among men, Sexual Health scores were significantly worse in treated patients and in those with a clinical outcome.
  
  
  CONCLUSIONS
  Clinical progression of chronic hepatitis C and maintenance peginterferon therapy led to worsening of symptoms, HRQOL and, in men, sexual health in a large patient cohort followed up over 4 years (NCT00006164).
authors.affiliation: New England Research Institutes, Watertown, MA 02472, USA. ksnow@neriscience.com
authors.forename: K K
authors.initials: KK
authors.lastname: Snow
authors.forename: H L
authors.initials: HL
authors.lastname: Bonkovsky
authors.forename: R J
authors.initials: RJ
authors.lastname: Fontana
authors.forename: H-Y
authors.initials: HY
authors.lastname: Kim
authors.forename: R K
authors.initials: RK
authors.lastname: Sterling
authors.forename: A M
authors.initials: AM
authors.lastname: Di Bisceglie
authors.forename: T R
authors.initials: TR
authors.lastname: Morgan
authors.forename: J L
authors.initials: JL
authors.lastname: Dienstag
authors.forename: M G
authors.initials: MG
authors.lastname: Ghany
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D005221:Fatigue / Q000150:complications / Q000523:psychology; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000523:psychology / Q000821:virology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000523:psychology / Q000821:virology; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D011788:Quality of Life / Q000523:psychology; D011994:Recombinant Proteins; D012725:Sexual Behavior / Q000187:drug effects* / Q000523:psychology; D012959:Socioeconomic Factors
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C100416:peginterferon alfa-2a