title: Dental enamel: genes define biomechanics.
abstract: Regulated gene expression assembles an extracellular proteinaceous matrix to control biomineralization and the resultant biomechanical function of tooth enamel. The importance of the dominant enamel matrix protein, amelogenin (Amel); a minor transiently expressed protein, dentin sialoprotein (Dsp); an electrogenic sodium bicarbonate cotransporter (NBCe1); the timely removal of the proteinaceous matrix by a serine protease, Kallikrein-4 (Klk4); and the late-stage expression of Amelotin (Amtn) on enamel biomechanical function were demonstrated and measured using mouse models.
authors.affiliation: University of California, Los Angeles, School of Dentistry, USA.
authors.forename: Rick J
authors.initials: RJ
authors.lastname: Rauth
authors.forename: Karen S
authors.initials: KS
authors.lastname: Potter
authors.forename: Amanda Y-W
authors.initials: AY
authors.lastname: Ngan
authors.forename: Deema M
authors.initials: DM
authors.lastname: Saad
authors.forename: Rana
authors.initials: R
authors.lastname: Mehr
authors.forename: Vivian Q
authors.initials: VQ
authors.lastname: Luong
authors.forename: Verna L
authors.initials: VL
authors.lastname: Schuetter
authors.forename: Vetea G
authors.initials: VG
authors.lastname: Miklus
authors.forename: PeiPei
authors.initials: P
authors.lastname: Chang
authors.forename: Michael L
authors.initials: ML
authors.lastname: Paine
authors.forename: Rodrigo S
authors.initials: RS
authors.lastname: Lacruz
authors.forename: Malcolm L
authors.initials: ML
authors.lastname: Snead
authors.forename: Shane N
authors.initials: SN
authors.lastname: White
mesh_terms: D053523:Amelogenin / Q000235:genetics; D000818:Animals; D001696:Biomechanical Phenomena; D003743:Dental Enamel / Q000502:physiology*; D003746:Dental Enamel Proteins / Q000235:genetics*; D016326:Extracellular Matrix Proteins / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics; D007610:Kallikreins / Q000235:genetics; D051379:Mice; D023421:Models, Animal; D010750:Phosphoproteins / Q000235:genetics; D012795:Sialoglycoproteins / Q000235:genetics; D027982:Sodium-Bicarbonate Symporters / Q000235:genetics; D014074:Tooth Calcification / Q000235:genetics; D000099311:Dentin Sialophosphoprotein
chemical_list: D053523:Amelogenin; D003746:Dental Enamel Proteins; D016326:Extracellular Matrix Proteins; D007610:Kallikreins; D010750:Phosphoproteins; D012795:Sialoglycoproteins; D027982:Sodium-Bicarbonate Symporters; D000099311:Dentin Sialophosphoprotein; C507066:Amtn protein, mouse; C120801:kallikrein 4