ENY2: couple, triple...more?
ENY2/Sus1, a protein involved in the coupling of transcription with mRNA export, is a component of SAGA/TFTC and TREX-2/AMEX complexes. Recently, we have described the association of ENY2 with the third protein complex, THO. Moreover, our data indicate that ENY2 is also associated with other factors, both in the nucleus and cytoplasm. Thus, being a shared components of several protein complexes, ENY2 appears to function as an adapter molecule involved in integration of cellular processes, in particular, subsequent stages of gene expression.
Kopytova
Daria V
DV
Department of Regulation of Gene Expression, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Krasnov
Alexey N
AN
Orlova
Anastasija V
AV
Gurskiy
Dmitriy Ya
DY
Nabirochkina
Elena N
EN
Georgieva
Sofa G
SG
Shidlovskii
Yulii V
YV
D000818:Animals; D004331:Drosophila melanogaster / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D012261:Ribonucleoproteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*
D012261:Ribonucleoproteins; D014157:Transcription Factors; C026452:messenger ribonucleoprotein