title: The role of ultraviolet radiation in melanomagenesis.
abstract: The role of ultraviolet radiation (UV) in the pathogenesis has been discussed controversially for many decades. Studies in mice (SCID, HGF/SF, SV40T) which develop malignant melanoma, show a role of UVB in melanomagenesis. In contrast to this, the role of UVA is less clear. We will review the recent in vitro and in vivo data in support of the hypothesis that UVA is also involved in the development of malignant melanoma. The role of UVA in p53 activation, apoptosis, cell cycle arrest and photoproduct formation is discussed.
authors.affiliation: Department of Dermatology, Eberhard Karls University, Tübingen, Germany.
authors.forename: Anna-Katharina
authors.initials: AK
authors.lastname: von Thaler
authors.forename: York
authors.initials: Y
authors.lastname: Kamenisch
authors.forename: Mark
authors.initials: M
authors.lastname: Berneburg
mesh_terms: D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D004249:DNA Damage; D004195:Disease Models, Animal; D006801:Humans; D008545:Melanoma / Q000209:etiology* / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D018384:Oxidative Stress; D012878:Skin Neoplasms / Q000209:etiology* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D016159:Tumor Suppressor Protein p53