title: [Cardiotoxicity induced by chemo- and radiotherapy].
abstract: The authors describe the case of a 55-year old patient, with dyslipidemia as single cardiovascular risk factor, who previously underwent chemo and radiotherapy for Hodgkin lymphoma (stage 2b). The patient developed early coronary atherosclerosis followed by aortic and mitral valve disease and initial constrictive pericarditis. The role of chemo and radiotherapy in the development of cardiovascular disease, in particular valvular and pericardial disease, is discussed.
authors.affiliation: Istituto di Fisiologia Clinica e Fondazione Toscana Gabriele Monasterio, Pisa.
authors.forename: Vera
authors.initials: V
authors.lastname: Srebot
authors.forename: Francesco
authors.initials: F
authors.lastname: Sbrana
authors.forename: Alessio
authors.initials: A
authors.lastname: Maffei
authors.forename: Marco
authors.initials: M
authors.lastname: Solinas
authors.forename: Daniele
authors.initials: D
authors.lastname: Rovai
mesh_terms: D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D001022:Aortic Valve Insufficiency / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000209:etiology*; D003324:Coronary Artery Disease / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000209:etiology*; D004317:Doxorubicin / Q000009:adverse effects*; D015150:Echocardiography, Doppler; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008944:Mitral Valve Insufficiency / Q000139:chemically induced / Q000209:etiology*; D009367:Neoplasm Staging; D010494:Pericarditis, Constrictive / Q000139:chemically induced / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin