Phenolic compounds from Cryptocarya konishii: their cytotoxic and tyrosine kinase inhibitory properties.
Two chalcone derivatives, 2'-hydroxychalcone (1) and desmethylinfectocaryone (2), together with five known phenolic compounds infectocaryone (3), cryptocaryone (4), kurzichalcolactone A (5), pinocembrin (6) and trans-N-feruloyltyramine (7), were isolated from the methanol extract of the wood of Cryptocarya konishii. The structures of the new compounds were determined based on the analysis of spectroscopic data, including UV, IR, 1D and 2D NMR, and mass spectra. Evaluation of the cytotoxic and tyrosine kinase inhibitory activities of compounds 1-7 showed that compounds 2-4 strongly inhibited the growth of murine leukemia P-388 cells, whereas compound 4 significantly inhibited the enzyme.
Kurniadewi
Fera
F
Natural Products Research Group, Department of Chemistry, Bandung Institute of Technology, Jalan Ganeca 10, Bandung, Indonesia.
Juliawaty
Lia D
LD
Syah
Yana M
YM
Achmad
Sjamsul A
SA
Hakim
Euis H
EH
Koyama
Kiyotaka
K
Kinoshita
Kaoru
K
Takahashi
Kunio
K
D031369:Cryptocarya; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism
D003603:Cytotoxins; D010636:Phenols; D010936:Plant Extracts; D047428:Protein Kinase Inhibitors; D011505:Protein-Tyrosine Kinases