title: Synthesis and anti-human hepatocellular carcinoma activity of new nitric oxide-releasing glycosyl derivatives of oleanolic acid.
abstract: A series of nitric oxide (NO)-releasing glycosyl derivatives () of oleanolic acid were synthesized to improve the aqueous solubility and cytotoxicity of the parent compound . Derivative exhibited better solubility and strong cytotoxicity against human hepatocellular carcinoma (HCC) in vitro. Furthermore, displayed low acute toxicity to mice and significantly inhibited the growth of HCC tumors in vivo, indicating that may be a promising candidate for the treatment of human HCC.
authors.affiliation: Center of Drug Discovery, China Pharmaceutical University, Nanjing, PR China.
authors.forename: Zhangjian
authors.initials: Z
authors.lastname: Huang
authors.forename: Yihua
authors.initials: Y
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.forename: Yongwang
authors.initials: Y
authors.lastname: Jing
authors.forename: Yisheng
authors.initials: Y
authors.lastname: Lai
authors.forename: Luyong
authors.initials: L
authors.lastname: Zhang
authors.forename: Qinglong
authors.initials: Q
authors.lastname: Guo
authors.forename: Shengtao
authors.initials: S
authors.lastname: Yuan
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Sixun
authors.initials: S
authors.lastname: Peng
authors.forename: Jide
authors.initials: J
authors.lastname: Tian
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D055808:Drug Discovery; D005260:Female; D006031:Glycosylation; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000737:chemistry*; D009828:Oleanolic Acid / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D012995:Solubility; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D014867:Water; D009569:Nitric Oxide; D009828:Oleanolic Acid