title: Oral epithelial hyperplasia in diabetes mellitus.
abstract: Diabetes mellitus is one of the chronic systemic disorders with major influences of the oral cavity microenvironment. Oral manifestations of diabetes are diverse; they are represented by candidose, lichen plan, recurrent aphthous stomatitis, gingivitis, salivary disorders, oral mucosa atrophy and rarely hypertrophy; a possible link between oral cancer and diabetes is suspected, both in animal models and humans. We report a case of a young woman with type 1 diabetes with class I Kennedy edentation with mobile denture prosthesis; latter in the clinical follow-up, a hyperplasic lesion of the oral mucosa with p53 expression within the epithelial nuclei was identified, p53 being the more likely pathogenic pathway involved in diabetes-related oral cancer. The approach of this patient required multidisciplinary investigations and careful follow-up.
authors.affiliation: Gr.T. Popa University of Medicine and Pharmacy, Iassy, Romania.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Girtan
authors.forename: Sabina
authors.initials: S
authors.lastname: Zurac
authors.forename: Florica
authors.initials: F
authors.lastname: Stăniceanu
authors.forename: Alexandra
authors.initials: A
authors.lastname: Bastian
authors.forename: Cristiana
authors.initials: C
authors.lastname: Popp
authors.forename: Luciana
authors.initials: L
authors.lastname: Nichita
authors.forename: Elisabeta
authors.initials: E
authors.lastname: Laba
authors.forename: Norina
authors.initials: N
authors.lastname: Forna
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D017573:Focal Epithelial Hyperplasia / Q000150:complications* / Q000473:pathology*; D006801:Humans; D009062:Mouth Neoplasms / Q000150:complications* / Q000473:pathology*