Increased risk of chronic kidney disease in elderly with metabolic syndrome and high levels of C-reactive protein: Kahrizak Elderly Study.
BACKGROUND
To explore the interrelationship between metabolic syndrome (MS), chronic kidney disease (CKD) and C-reactive protein (CRP) in an elderly Iranian cohort.


METHODS
122 residents of Kahrizak Charity Foundation aged >or= 60 years were enrolled in this survey. MS was defined according to the NCEP-ATPIII criteria. CKD was defined as an estimated glomerular filtration rate < 60 ml/min/1.73 m2. CRP levels >or= 3 mg/dl were determined as a high CRP.


RESULTS
The multivariate-adjusted odds ratio (OR) for CKD in MS was 5.81 (95% confidence interval (CI) 1.72-19.58) compared to those without MS. High blood pressure and high triglyceride levels were significantly associated with an increased risk of CKD (OR 4.01, 95% CI 1.55-10.37 and OR 3.27, 95% CI 1.25-8.53, respectively). Subjects with MS and high CRP levels had a 1.71-fold greater risk of having CKD compared to those without MS and low CRP levels (95% CI 1.02-2.84).


CONCLUSIONS
There was a strong and independent relation between MS and risk of CKD in these elderly people. High blood pressure and hypertriglyceridemia increased the risk of CKD. Combination of high CRP and MS was strongly associated with an increased risk of CKD.
Fakhrzadeh
Hossein
H
Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran. fakhrzad@tums.ac.ir
Ghaderpanahi
Maryam
M
Sharifi
Farshad
F
Badamchizade
Zohre
Z
Mirarefin
Mojde
M
Larijani
Bagher
B
D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D002097:C-Reactive Protein / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006306:Health Surveys; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000503:physiopathology; D015228:Hypertriglyceridemia / Q000097:blood; D007492:Iran / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000209:etiology; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D016017:Odds Ratio; D012307:Risk Factors; D055105:Waist Circumference
D008076:Cholesterol, HDL; D008055:Lipids; D002097:C-Reactive Protein