Cough: The Emerging Role of the TRPA1 Channel.
Sneezing, cough, mucus secretion, and bronchoconstriction represent the main components of a coordinated and efficient reaction direct to expel or neutralize irritant agents from the respiratory system. A dense network of sensory nerves localized from the nose to the lower airways beneath the epithelium subserves this function. A variety of receptors and channels present in sensory nerve terminals by sensing irritant stimuli activate the system in emergence and initiate protective reflex responses, including cough. Previous and recent literature highlights the prominent role of some transient receptor potential (TRP) ion channels, and specifically the vanilloid 1 (TRPV1) and the ankyrin 1 (TRPA1) as sensors of airway irritation and initiators of the cough reflex.
Geppetti
Pierangelo
P
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy, geppetti@unifi.it.
Patacchini
Riccardo
R
Nassini
Romina
R
Materazzi
Serena
S
D000818:Animals; D001249:Asthma / Q000503:physiopathology; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D002211:Capsaicin / Q000494:pharmacology; D003371:Cough / Q000209:etiology / Q000503:physiopathology*; D006168:Guinea Pigs; D006801:Humans; D007509:Irritants / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism / Q000503:physiopathology; D012018:Reflex / Q000502:physiology*; D012137:Respiratory System / Q000294:innervation*; D000074025:TRPA1 Cation Channel; D050916:TRPV Cation Channels / Q000037:antagonists & inhibitors / Q000502:physiology; D050051:Transient Receptor Potential Channels / Q000187:drug effects / Q000502:physiology*
D015220:Calcium Channels; D007509:Irritants; D009419:Nerve Tissue Proteins; D000074025:TRPA1 Cation Channel; C473350:TRPA1 protein, human; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; D050051:Transient Receptor Potential Channels; D002211:Capsaicin