title: The accuracy of dose-rate-regulated tracking: a parametric study.
abstract: Dose-rate-regulated tracking (DRRT) is a novel tumor-tracking technique based on a preprogrammed multileaf-collimator (MLC) sequence and dose-rate modulation. We have performed a parametric study on how limitations of the DRRT system and breathing irregularities affect the tracking error and the duty cycle of DRRT. The time delay and the allowed dose-rate increment (continuous-, discrete-increment or beam switching) were used as two parameters for the DRRT system limitation. The breathing irregularity was quantified in terms of three variables, namely, breathing period variation, variation of peak-to-peak amplitude and baseline drift. DRRT treatments were simulated using 2126 breathing cycles obtained from 24 lung-cancer patients. Tracking errors and duty cycles from all 24 patients were combined to evaluate their dependence on each parameter or variable. The tracking error and the duty cycle show a modest difference among the three dose-rate-increment cases. Time delay, breathing peak-to-peak variation and baseline drift are the main factors affecting tracking error. The duty cycle is affected mostly by the allowed dose-rate increment, peak-to-peak variation and baseline drift.
authors.affiliation: Department of Physics, The George Washington University, Washington, DC 20052, USA.
authors.forename: S
authors.initials: S
authors.lastname: Han-Oh
authors.forename: B
authors.initials: B
authors.lastname: Yi
authors.forename: B L
authors.initials: BL
authors.lastname: Berman
authors.forename: F
authors.initials: F
authors.lastname: Lerma
authors.forename: C
authors.initials: C
authors.lastname: Yu
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy; D009038:Motion; D010507:Periodicity; D011878:Radiotherapy / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012119:Respiration; D013997:Time Factors