Autophagy in viral replication and pathogenesis.
Autophagy is a catabolic process that is important for the removal of damaged organelles and long-lived proteins for the maintenance of cellular homeostasis. It can also serve as innate immunity to remove intracellular microbial pathogens. A growing list of viruses has been shown to affect this cellular pathway. Some viruses suppress this pathway for their survival, while others enhance or exploit this pathway to benefit their replication. The effect of viruses on autophagy may also sensitize cells to death or enhance cell survival and play a critical role in viral pathogenesis. In this article, we review the relationships between different viruses and autophagy and discuss how these relationships may affect viruses and their host cells.
Sir
Donna
D
Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA.
Ou
Jing-hsiung James
JH
D000818:Animals; D001343:Autophagy; D002470:Cell Survival; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D008561:Membrane Fusion; D014777:Virus Diseases / Q000276:immunology / Q000473:pathology / Q000821:virology; D014779:Virus Replication