title: Colchicinoids from Colchicum crocifolium Boiss. (Colchicaceae).
abstract: A new colchicinoid from Colchicum crocifolium Boiss. (Colchicaceae) was isolated and identified as N,N-dimethyl-N-deacetyl-(-)-cornigerine (5), along with four known compounds, but new to the species: (-)-colchicine (1), (-)-demecolcine (2), (-)-N-methyl-(-)-demecolcine (3) and 3-demethyl-N-methyl-(-)-demecolcine (4). All isolated compounds showed potent cytotoxicity against a human cancer cell panel.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan. falali@just.edu.jo
authors.forename: Feras Q
authors.initials: FQ
authors.lastname: Alali
authors.forename: Ahmad A
authors.initials: AA
authors.lastname: Gharaibeh
authors.forename: Abdullah
authors.initials: A
authors.lastname: Ghawanmeh
authors.forename: Khaled
authors.initials: K
authors.lastname: Tawaha
authors.forename: Amjad
authors.initials: A
authors.lastname: Qandil
authors.forename: Jason P
authors.initials: JP
authors.lastname: Burgess
authors.forename: Arlene
authors.initials: A
authors.lastname: Sy
authors.forename: Yuka
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: David J
authors.initials: DJ
authors.lastname: Kroll
authors.forename: Nicholas H
authors.initials: NH
authors.lastname: Oberlies
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003079:Colchicum / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts