title: Amino acids from Mytilus galloprovincialis (L.) and Rapana venosa molluscs accelerate skin wounds healing via enhancement of dermal and epidermal neoformation.
abstract: Wound healing consists of re-epithelialization, contraction and formation of granulation and scar tissue. Amino acids from proteins are involved in these events, but their exact roles are not well understood. The present study was undertaken to investigate the anti-inflammatory effects of some amino acids from two molluscs, Mytilus galloprovincialis (L.) (Mediterranean mussel) and Rapana venosa (hard shell-clam) employed in induced skin burn injuries in Wistar rats. The treatment was evaluated in terms of essential amino acids composition which rendered the extracts very efficient in healing skin burns. The healing process was examined by periodic acid Schiff's, Verhoeff's Van Gieson and immunohistochemistry stains for collagen IV, CD 34 and CD 117 antibodies. According to the obtained results, as expressed by histological studies, the most abundant blood vessels, collagen fibres, basal and stem cells were found only for treated animals with amino acids from Rapana venosa extracts. The rich composition of amino acids from the two molluscs merits consideration as therapeutic agents in the treatment of skin burns.
authors.affiliation: Department of Biology-Biochemistry, Faculty of Natural and Agricultural Sciences, Ovidius University of Constanta, 124 Mamaia Blvd., 900527, Constanta, Romania. dianabadiu@yahoo.com
authors.forename: Diana L
authors.initials: DL
authors.lastname: Badiu
authors.forename: Rafael
authors.initials: R
authors.lastname: Luque
authors.forename: Elena
authors.initials: E
authors.lastname: Dumitrescu
authors.forename: Anca
authors.initials: A
authors.lastname: Craciun
authors.forename: Danut
authors.initials: D
authors.lastname: Dinca
mesh_terms: D000596:Amino Acids / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D049872:Bivalvia / Q000737:chemistry*; D002056:Burns / Q000188:drug therapy / Q000473:pathology; D008297:Male; D049878:Mytilus / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects / Q000502:physiology; D012867:Skin / Q000187:drug effects / Q000293:injuries / Q000378:metabolism; D014020:Tissue Extracts / Q000737:chemistry*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000596:Amino Acids; D014020:Tissue Extracts