title: Vas deferens--a model used to establish sympathetic cotransmission.
abstract: The vas deferens has been used as a model for many diverse studies of different aspects of autonomic neurotransmission since its introduction including, in particular, sympathetic cotransmission involving release of ATP and neuropeptide Y together with noradrenaline and prejunctional and postjunctional neuromodulation. It has also been used to study sympathetic reinnervation following vasectomy and castration, as well as the deleterious effects of diabetes, hypertension and chronic alcohol.
authors.affiliation: Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK. g.burnstock@ucl.ac.uk
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Burnstock
authors.forename: Alexej
authors.initials: A
authors.lastname: Verkhratsky
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000375:Aging / Q000378:metabolism / Q000502:physiology; D000818:Animals; D006801:Humans; D008297:Male; D008954:Models, Biological; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000254:growth & development / Q000294:innervation / Q000378:metabolism; D009469:Neuromuscular Junction / Q000502:physiology; D009478:Neuropeptide Y / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*; D014649:Vas Deferens / Q000254:growth & development / Q000294:innervation* / Q000378:metabolism; D014781:Viscera / Q000294:innervation / Q000502:physiology
chemical_list: D009478:Neuropeptide Y; D018377:Neurotransmitter Agents; D000255:Adenosine Triphosphate; D009638:Norepinephrine