Association between foetal growth and different maternal metabolic characteristics in women with gestational diabetes mellitus.
OBJECTIVE
The aim of the study was to investigate the association between foetal growth and different maternal metabolic characteristics in women with gestational diabetes mellitus (GDM).


METHODS
The study group included 200 consecutive pregnant women who attended the Endocrinology, Diabetes and Metabolic Disorders Outpatient Department in the period from 02.2006 to 02.2009 with singleton pregnancy and GDM diagnosed following ADA criteria. The following parameters were studied: pre-pregnancy maternal body mass index (BMI), 3-hours 100g oral glucose tolerance test (OGTT) results, glycosylated haemoglobin (HbA1c), total lipids (TL), total cholesterol (TH), triglycerides (TG), HDL- and LDL-cholesterol levels at admission. Neonatal birth weight and the prevalence of being large for gestational age (LGA) was an end-point.


RESULTS
We found a significant association between birth weight and pre-pregnancy BMI, HDL-C and birth weight of a large child born previously. Birth weight of a large child born previously was the strongest independent predictor for LGA. The prevalence of LGA (from 27% to 80%) was related to a number of altered maternal characteristics.


CONCLUSIONS
Pre-pregnancy BMI, HDL-C and birth weight of a large child born previously are the independent predictors for LGA, but results of glucose levels during OGTT are not useful in the prediction of LGA in GDM pregnancies. Probably more factors and other maternal metabolic parameters than glucose levels during OGTT are responsible for the risk of LGA.
Krstevska
B
B
Endocrinology, Diabetes and Metabolic Disorders Clinic, Medical Faculty, Skopje, R. Macedonia. branakrstevska@yahoo.com
Velkoska Nakova
V
V
Adamova
G
G
Simeonova
S
S
Dimitrovski
Ch
Ch
Livrinova
V
V
Serafimoski
V
V
D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D047109:Fetal Development; D005320:Fetal Macrosomia / Q000209:etiology*; D005865:Gestational Age; D005951:Glucose Tolerance Test; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D055815:Young Adult
D001786:Blood Glucose; D008076:Cholesterol, HDL