title: In vivo imaging of RNA interference.
abstract: RNA interference (RNAi), an effective technique for regulating or silencing specific genes, can be applied to treat various diseases. Multiple clinical trials using RNAi are ongoing, and molecular imaging can serve as a powerful tool in RNAi-based therapies. This brief review will highlight the current progress on in vivo imaging of RNAi delivery and silencing effects. Incorporation of suitable molecular imaging techniques into future RNAi-based clinical trials will provide more pieces of the puzzle, thus facilitating the transformation of RNAi into a powerful therapeutic modality in the clinic.
authors.affiliation: Departments of Radiology and Medical Physics and University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
authors.forename: Hao
authors.initials: H
authors.lastname: Hong
authors.forename: Yin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Weibo
authors.initials: W
authors.lastname: Cai
mesh_terms: D000818:Animals; D020868:Gene Silencing; D006801:Humans; D008163:Luminescent Measurements; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008856:Microscopy, Fluorescence; D057054:Molecular Imaging / Q000379:methods*; D049268:Positron-Emission Tomography; D045663:Quantum Dots; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics / Q000627:therapeutic use; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D034741:RNA, Small Interfering