title: Particle shape: a new design parameter for passive targeting in splenotropic drug delivery.
abstract: The role of particle size and surface modification on biodistribution of nanocarriers is widely reported. We report for the first time the role of nanoparticle shape on biodistribution. Our study demonstrates that irregular shaped polymer lipid nanoparticles (LIPOMER) evade kupffer cells and localize in the spleen. We also demonstrate the macrophage-evading characteristic of the irregular-shaped LIPOMER. Our results suggest particle shape as an important tool for passive targeting of nanocarriers in splenotropic drug delivery.
authors.affiliation: Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N.P. Marg, Matunga (E), Mumbai 400019, Maharashtra, India. pvdevarajan@gmail.com
authors.forename: Padma V
authors.initials: PV
authors.lastname: Devarajan
authors.forename: Anil B
authors.initials: AB
authors.lastname: Jindal
authors.forename: Rajesh R
authors.initials: RR
authors.lastname: Patil
authors.forename: Fernaz
authors.initials: F
authors.lastname: Mulla
authors.forename: Rajiv V
authors.initials: RV
authors.lastname: Gaikwad
authors.forename: Abdul
authors.initials: A
authors.lastname: Samad
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008264:Macrophages / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D020849:Raloxifene Hydrochloride; D014018:Tissue Distribution
chemical_list: D008055:Lipids; D011108:Polymers; D020849:Raloxifene Hydrochloride