[Novel complex, formed by transcription coactivator SAYP].
The multisubunit complex which contains the novel evolutionarily conservative transcription factor SAYP was isolated and the protein composition of the complex was determined. It was shown that SAYP unites two complexes with different functions in transcription activation: the chromatin - remodeling complex PBAP (SWI/SNF) and the main component of preinitiation complex of Pol II, general transcription factor TFIID. The isolated super-complex contained the full set of PBAP and TFIID subunits. All components of supercomplex (SAYP, TFIID and PBAP) are essential for its effective interaction with promoters of SAYP-dependent genes.
Soshnikova
N V
NV
Vorob'eva
N E
NE
Krasnov
A N
AN
Georgieva
S G
SG
Nabirochkina
E N
EN
Shidlovskiĭ
Iu V
IuV
D000818:Animals; D002460:Cell Line; D042002:Chromatin Assembly and Disassembly / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism*; D011401:Promoter Regions, Genetic / Q000502:physiology; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism; D035362:Transcription Factor TFIID / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology*
D029721:Drosophila Proteins; D046912:Multiprotein Complexes; C492947:SWI protein, D melanogaster; D035362:Transcription Factor TFIID; D014157:Transcription Factors; C499490:e(y)3 protein, Drosophila; D012319:RNA Polymerase II