title: Modified phenazines from an Indonesian Streptomyces sp.
abstract: Fractionation of the extract from the Indonesian Streptomyces sp. ICBB8198 as directed by the antibacterial activity delivered the known phenazine antibiotics griseoluteic acid (1a) and griseolutein A (1b), as well as two new phenazine derivatives (2 and 3). In addition, the known compounds spirodionic acid, dihydrosarkomycins, and 6-ethyl-4-hydroxy-3,5-dimethyl-2H-pyran-2-one (4a), along with the new pyrone 3,6-diethyl-4-hydroxy-5-methyl-2H-pyran-2-one (4b), were isolated. We report here the isolation, structure elucidation, and antibiotic activity of the new metabolites as well as a hypothetical pathway for the formation of the new phenazine derivatives.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, USA.
authors.forename: Serge
authors.initials: S
authors.lastname: Fotso
authors.forename: Dwi Andreas
authors.initials: DA
authors.lastname: Santosa
authors.forename: Rasti
authors.initials: R
authors.lastname: Saraswati
authors.forename: Jongtae
authors.initials: J
authors.lastname: Yang
authors.forename: Taifo
authors.initials: T
authors.lastname: Mahmud
authors.forename: T Mark
authors.initials: TM
authors.lastname: Zabriskie
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Proteau
mesh_terms: D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D007214:Indonesia; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009089:Mucor / Q000187:drug effects; D010619:Phenazines / Q000737:chemistry / Q000302:isolation & purification*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D010619:Phenazines