title: Preimplantation genetic diagnosis (PGD) for HLA typing: bases for setting up an open international collaboration when PGD is not available.
abstract: In severe forms of Diamond-Blackfan anemia, preimplantation genetic diagnosis (PGD) of histocompatibility leukocyte antigen-compatible embryos for enabling the next sibling in the family to be a stem-cell transplantation donor constitutes the sole lasting cure capable of terminating the enduring need for iterative transfusions. We report here an open collaboration between two renowned institutions to provide a family desiring this treatment even though they resided where the preimplantation genetic diagnosis procedure is banned.
authors.affiliation: Reproductive Endocrinology and Infertility, Department of Gynecology-Obstetrics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors.forename: Marina
authors.initials: M
authors.lastname: Bellavia
authors.forename: Nicolas
authors.initials: N
authors.lastname: Von Der Weid
authors.forename: Christina
authors.initials: C
authors.lastname: Peddes
authors.forename: Sebastien
authors.initials: S
authors.lastname: Jacquemont
authors.forename: Inge
authors.initials: I
authors.lastname: Liebaers
authors.forename: Patrick
authors.initials: P
authors.lastname: Hohlfeld
authors.forename: Dorothea
authors.initials: D
authors.lastname: Wunder-Galié
authors.forename: Dominique
authors.initials: D
authors.lastname: de Ziegler
mesh_terms: D000328:Adult; D029503:Anemia, Diamond-Blackfan / Q000628:therapy; D002648:Child; D033001:Directed Tissue Donation / Q000331:legislation & jurisprudence; D005260:Female; D005307:Fertilization in Vitro; D006297:Health Services Accessibility / Q000331:legislation & jurisprudence; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D007391:International Cooperation; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000379:methods / Q000706:statistics & numerical data*; D012801:Sibling Relations; D035781:Siblings; D033581:Stem Cell Transplantation / Q000379:methods; D013557:Switzerland; D014184:Transplantation, Homologous