[Cembrane diterpenes in olibanum].
OBJECTIVE
To study the constituents in the chloroform extract of olibanum and their antitumor activities.


METHODS
The compounds were isolated by chromatographic methods and their structures were identified on the basis of spectroscopic methods and X-ray diffraction. The antiproliferative effect of the compounds in human leukemia HL-60 cells was tested by viable cell counting.


RESULTS
Four cembrane diterpenes were isolated and identified as incensole-oxide (1), acetyl incensole-oxide (2), incensole (3), and acetyl incensole (4).


CONCLUSIONS
Compounds 2 and 4 were isolated from the genus Boswellia for the first time. Compound 4 showed growth inhibitory effect against human leukemia HL-60 cell lines with IG50 value of (16.3 +/- 3.4) micromol x L(-1).
Wang
Feng
F
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Li
Zhanlin
Z
Liu
Tao
T
Hua
Huiming
H
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D029743:Boswellia / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts