Fuscacarpans A-C, new pterocarpans from the stems of Erythrina fusca.
Chemical investigation of the stems of Erythrina fusca Lour. led to the isolation of three new pterocarpans, named fuscacarpans A-C (1-3), together with fourteen known compounds, sandwicensin (4), erythribyssin A (5), erythrabissin I (6), demethylmedicarpin (7), eryvarin D (8), erypoegin I (9), hydroxycristacarpone (10), orientanol A (11), scandenone (12), genistein (13), liquiritigenin (14), isoliquiritigenin (15), vestitone (16) and 3,7,4'-trihydroxyflavone (17). Structures 1-3 were elucidated by spectroscopic and chemical methods. The isolates were evaluated for antibacterial, antiplasmodial and cytotoxic activities.
Innok
Phongsak
P
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.
Rukachaisirikul
Thitima
T
Phongpaichit
Souwalak
S
Suksamrarn
Apichart
A
D000900:Anti-Bacterial Agents / Q000032:analysis; D000962:Antimalarials / Q000032:analysis; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004895:Erythrina / Q000737:chemistry*; D006801:Humans; D008968:Molecular Conformation; D009904:Optical Rotation; D018547:Plant Stems / Q000737:chemistry; D036343:Pterocarpans / Q000737:chemistry / Q000302:isolation & purification*
D000900:Anti-Bacterial Agents; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D036343:Pterocarpans; C553382:fuscacarpan A; C553383:fuscacarpan B; C553384:fuscacarpan C