title: Structure and antibacterial activity of brominated diterpenes from the red alga Sphaerococcus coronopifolius.
abstract: Four new tetracyclic brominated diterpenes, 1-4, were isolated from the organic extract of Sphaerococcus coronopifolius, collected from the rocky coasts of Corfu Island. The structures of the new natural products, as well as their relative configurations, were elucidated on the basis of extensive spectral analyses, including 2D-NMR experiments. The isolated metabolites were evaluated for their antibacterial activity against a panel of bacteria including multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) with MIC values in the range of 16-128 microg/ml.
authors.affiliation: Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, GR-Athens 15771.
authors.forename: Vangelis
authors.initials: V
authors.lastname: Smyrniotopoulos
authors.forename: Constantinos
authors.initials: C
authors.lastname: Vagias
authors.forename: Mukhlesur M
authors.initials: MM
authors.lastname: Rahman
authors.forename: Simon
authors.initials: S
authors.lastname: Gibbons
authors.forename: Vassilios
authors.initials: V
authors.lastname: Roussis
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018432:Drug Resistance, Multiple / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D000461:Rhodophyta / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes