MIRD Pamphlet No. 22 (abridged): radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy.
The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of alpha-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with alpha-particle emitters. Although alpha-emitters have been studied for many decades, their current use in humans for targeted therapy is an important milestone. The objective of this work is to review those aspects of the field that are pertinent to targeted alpha-particle emitter therapy and to provide guidance and recommendations for human alpha-particle emitter dosimetry.
Sgouros
George
G
Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA. gsgouros@jhmi.edu
Roeske
John C
JC
McDevitt
Michael R
MR
Palm
Stig
S
Allen
Barry J
BJ
Fisher
Darrell R
DR
Brill
A Bertrand
AB
Song
Hong
H
Howell
Roger W
RW
Akabani
Gamal
G
Bolch
Wesley E
WE
Brill
A Bertrand
AB
Fisher
Darrell R
DR
Howell
Roger W
RW
Meredith
Ruby F
RF
Sgouros
George
G
Wessels
Barry W
BW
Zanzonico
Pat B
PB
D000512:Alpha Particles / Q000009:adverse effects / Q000627:therapeutic use*; D016923:Cell Death / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects; D002986:Clinical Trials as Topic; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000532:radiotherapy*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D010174:Pamphlets; D011837:Radiation-Protective Agents / Q000627:therapeutic use; D011853:Radiobiology; D011868:Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012062:Relative Biological Effectiveness; D012955:Societies, Medical
D011837:Radiation-Protective Agents; D011868:Radioisotopes