[The effect of gastric electrical stimulation on cisplatin-induced emesis in dogs.].
OBJECTIVE
The aims of this study were to investigate the effects of cisplatin (DDP) on gastric myoelectrical activity and the roles of gastric electrical stimulation (GES) in the treatment of drug-induced emesis in dogs.


METHODS
Four pairs of electrodes were implanted in gastric serosa in seven female dogs, all dogs performed followed two-session study: intravenous infusion of DDP (1.5 mg/kg) was given for 1 h in DDP-control session and DDP-GES session. Trains of short pulses GES was applied on the proximal pair of gastric electrodes from drugs infusion. It lasted 6 h in GES session. Gastric slow waves and animal behaviors were recorded in each session.


RESULTS
(1) DDP induced nausea and gastric dysrhythmia. The total number of emesis was 5.5 +/- 1.2 in DDP-control session, and the total symptom score was 31.83 +/- 2.75. The gastric slow wave showed both bradygastria and tachygastria during the period of emesis (P = 0.031 and 0.020 vs baseline). The percentage of normal slow wave was (69.61 +/- 5.81)% during this period (P = 0.003 vs baseline). (2) GES reduced emesis and the animal behavioral score suggestive of nausea compared with DDP-control sessions. The total behavioral score and total number of emesis decreased in this session (all the P < 0.05). However, GES had no effects on gastric dysrhythmia.


CONCLUSIONS
DDP induced emesis and gastric dysrhythmia. GES with trains of short pulses relieves drug-induced emetic responses but has no effects on dysrhythmia.
Yu
Xiao-Yun
XY
Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Email: houxh@public.wh.hb.cn.
Tu
Lei
L
Yang
Jie
J
Hou
Xiao-Hua
XH
Qian
Wei
W
Chen
Jian-de
JD
D000818:Animals; D002945:Cisplatin; D004285:Dogs; D004558:Electric Stimulation; D013270:Stomach / Q000187:drug effects; D013272:Stomach Diseases; D014839:Vomiting
D002945:Cisplatin