Eukaryotic cold shock domain proteins: highly versatile regulators of gene expression.
Cold shock domain (CSD)-containing proteins have been found in all three domains of life and function in a variety of processes that are related, for the most part, to post-transcriptional gene regulation. The CSD is an ancient beta-barrel fold that serves to bind nucleic acids. The CSD is structurally and functionally similar to the S1 domain, a fold with otherwise unrelated primary sequence. The flexibility of the CSD/S1 domain for RNA recognition confers an enormous functional versatility to the proteins that contain them. This review summarizes the current knowledge on eukaryotic CSD/S1 domain-containing proteins with a special emphasis on UNR (upstream of N-ras), a member of this family with multiple copies of the CSD.
Mihailovich
Marija
M
Gene Regulation Programme, Centre de Regulació Genòmica (CRG-UPF), Barcelona, Spain.
Militti
Cristina
C
Gabaldón
Toni
T
Gebauer
Fátima
F
D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism*; D039642:Eukaryotic Initiation Factors / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D055354:Exosomes / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D010802:Phylogeny; D017433:Protein Structure, Secondary; D012097:Repressor Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism; D051840:Y-Box-Binding Protein 1 / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism
D029742:Caenorhabditis elegans Proteins; D039642:Eukaryotic Initiation Factors; D006360:Heat-Shock Proteins; C452195:LIN-28 protein, C elegans; D012097:Repressor Proteins; D051840:Y-Box-Binding Protein 1