title: Effects of glucosamine-chondroitin sulfate supplementation on serum fructosamine concentration in healthy dogs.
abstract: OBJECTIVE
  To determine whether short-term administration of an oral glucosamine-chondroitin sulfate (Glu-CS) supplement alters serum fructosamine concentration in healthy dogs.
  
  
  METHODS
  Prospective crossover study.
  
  
  METHODS
  12 healthy adult dogs.
  
  
  METHODS
  Dogs received Glu-CS and a placebo for 3 weeks each, with a 4-week minimum washout period between treatments. Serum fructosamine concentration was measured 4 times for each dog: prior to the first treatment period, at the end of the first treatment period, at the end of the washout period, and at the end of the second treatment period.
  
  
  RESULTS
  No significant change in serum fructosamine concentration was identified after treatment with either Glu-CS or the placebo. The change in serum fructosamine concentration associated with Glu-CS administration was not significantly different from the change in concentration associated with administration of the placebo.
  
  
  CONCLUSIONS
  Results suggest that in healthy dogs, short-term (ie, 21 days) oral Glu-CS administration does not affect glycemic control or cause diabetes mellitus.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Lenox
authors.forename: Katharine F
authors.initials: KF
authors.lastname: Lunn
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002809:Chondroitin Sulfates / Q000008:administration & dosage* / Q000378:metabolism; D004285:Dogs / Q000097:blood*; D004359:Drug Therapy, Combination; D019270:Fructosamine / Q000097:blood*; D005944:Glucosamine / Q000008:administration & dosage* / Q000378:metabolism; D008297:Male
chemical_list: D019270:Fructosamine; D002809:Chondroitin Sulfates; D005944:Glucosamine