Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model.
Curcumin can decrease viable cells through the induction of apoptosis in human lung cancer NCI-H460 cells in vitro. However, there are no reports that curcumin can inhibit cancer cells in vivo. In this study, NCI-H460 lung tumour cells were implanted directly into nude mice and divided randomly into four groups to be treated with vehicle, curcumin (30 mg/kg of body weight), curcumin (45 mg/kg of body weight) and doxorubicin (8 mg/kg of body weight). Each agent was injected once every 4 days intraperitoneally (i.p.), with treatment starting 4 weeks after inoculation with the NCI-H460 cells. Treatment with 30 mg/kg and 45 mg/kg of curcumin or with 8 mg/kg of doxorubicin resulted in a reduction in tumour incidence, size and weight compared with the control group. The findings indicate that curcumin can inhibit tumour growth in a NCI-H460 xenograft animal model in vivo.
Su
Chin-Cheng
CC
Division of General Surgery, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien 970, Taiwan.
Yang
Jai-Sing
JS
Lu
Chi-Cheng
CC
Chiang
Jo-Hua
JH
Wu
Chang-Lin
CL
Lin
Jen-Jyh
JJ
Lai
Kuang-Chi
KC
Hsia
Te-Chun
TC
Lu
Hsu-Feng
HF
Fan
Ming-Jen
MJ
Chung
Jing-Gung
JG
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D018287:Carcinoma, Large Cell / Q000188:drug therapy*; D045744:Cell Line, Tumor; D003474:Curcumin / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D023041:Xenograft Model Antitumor Assays
D000972:Antineoplastic Agents, Phytogenic; D004317:Doxorubicin; D003474:Curcumin