title: Work-related barriers and facilitators to antiretroviral therapy adherence in persons living with HIV infection.
abstract: Little is known about how the structure of work affects adherence to HIV antiretroviral therapy. We surveyed participants in an adherence intervention study to learn more about job characteristics, including measures of psychological demand and control, and job accommodations. Adherence was assessed using the Medication Event Monitoring System. Of 156 trial subjects, 69 were employed, and these 69 made 229 study visits. Psychological demands and control were unrelated to adherence, but the presence of workplace accommodations was significantly associated with adherence (P < 0.05). In multivariable models adjusting for clustering, those who reported having received an accommodation were 12% more adherent than those who did not receive an accommodation. Adherence was unrelated to experiencing side effects affecting work performance. Having the ability to institute job accommodations was more important to adherence than the psychosocial structure of the work. These potential benefits of requesting modifications need to be weighed against the possible risks of workplace disclosure.
authors.affiliation: The Department of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA, USA.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Torres-Madriz
authors.forename: Debra
authors.initials: D
authors.lastname: Lerner
authors.forename: Robin
authors.initials: R
authors.lastname: Ruthazer
authors.forename: William H
authors.initials: WH
authors.lastname: Rogers
authors.forename: Ira B
authors.initials: IB
authors.lastname: Wilson
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D016903:Drug Monitoring; D004651:Employment / Q000523:psychology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000523:psychology*; D006801:Humans; D008297:Male; D008404:Massachusetts; D008875:Middle Aged; D010349:Patient Compliance; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D017132:Workplace / Q000523:psychology
chemical_list: D019380:Anti-HIV Agents