Inhibition of prostaglandin E2 production by synthetic wogonin analogs.
Effects of wogonin analogs on cyclooxygenase-2 (COX-2) catalyzed prostaglandin E2 production on lipopolysaccharide (LPS)-induced RAW 264.7 cells were investigated. Wogonin analogs were prepared via several different synthetic pathways. Among wogonin analogs tested, 8-halogeno and 8-nitro analogs showed strong inhibitory activities against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells. Effect of wogonin was largely dependent on structural alteration of the 8-methoxy group.
Gurung
Santosh K
SK
College of Pharmacy, Kangwon National University, Chunchon 200-707, Republic of Korea.
Kim
Hyun Pyo
HP
Park
Haeil
H
D000818:Animals; D002460:Cell Line; D051546:Cyclooxygenase 2 / Q000187:drug effects*; D052246:Cyclooxygenase 2 Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015232:Dinoprostone / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D044950:Flavanones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D013329:Structure-Activity Relationship
D052246:Cyclooxygenase 2 Inhibitors; D044950:Flavanones; D008070:Lipopolysaccharides; D051546:Cyclooxygenase 2; D015232:Dinoprostone; C085514:wogonin