Cell division: the need for speed.
A bundle of microtubules known as the spindle midzone is rapidly assembled after anaphase onset, recruiting multiple signaling proteins that regulate cytokinesis. A new study reveals that positive feedback driven by clustering of a kinesin-6 motor underlies the explosive assembly of the spindle midzone.
Miller
Ann L
AL
Department of Zoology and Laboratory of Molecular Biology, University of Wisconsin-Madison, Madison, WI 53706, USA. almiller1@wisc.edu
Bement
William M
WM
D002455:Cell Division / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D008941:Spindle Apparatus / Q000502:physiology; D013997:Time Factors
D047908:Intracellular Signaling Peptides and Proteins