Anthelmintic constituents of Clonostachys candelabrum.
Five diastereomeric polyketide glycosides, roselipins 3A-3E (1-5), have been isolated from the acetone extract of Clonostachys candelabrum on the basis of their positive anthelmintic activity. The structures of these compounds were elucidated by comparison of their NMR and MS data to those of previously reported roselipins and related structures, and were confirmed by 2D-NMR spectral analysis. Known compounds linoleic acid (6) and aurantiogliocladin (7) were also isolated as active anthelmintic components, although much less potent than the roselipins.
Ayers
Sloan
S
Natural Products Chemistry, Merck Research Laboratories, Rahway, NJ, USA.
Zink
Deborah L
DL
Mohn
Kenneth
K
Powell
Joanne S
JS
Brown
Christine M
CM
Bills
Gerald
G
Grund
Alan
A
Thompson
Donald
D
Singh
Sheo B
SB
D000818:Animals; D000871:Anthelmintics / Q000737:chemistry* / Q000494:pharmacology*; D001681:Biological Assay; D002432:Cecum / Q000469:parasitology; D002851:Chromatography, High Pressure Liquid; D006999:Hypocreales / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D009349:Nematode Infections / Q000188:drug therapy / Q000469:parasitology; D009351:Nematospiroides dubius / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013270:Stomach / Q000469:parasitology; D013329:Structure-Activity Relationship
D000871:Anthelmintics; D007202:Indicators and Reagents