A novel interface consisting of homologous immunoglobulin superfamily members with multiple functions.
Immunoglobulin superfamily (IgSF) members account for a large proportion of cell adhesion molecules that perform important immunological functions, including recognizing a variety of counterpart molecules on the cell surface or extracellular matrix. The findings that CD155/poliovirus receptor (PVR) and CD112/nectin-2 are the ligands for CD226/platelet and T-cell activation antigen 1 (PTA1)/DNAX accessory molecular-1 (DNAM-1), CD96/tactile and Washington University cell adhesion molecule (WUCAM) and that CD226 is physically and functionally associated with lymphocyte function-associated antigen-1 (LFA-1) on natural killer (NK) and activated T cells have largely expanded our knowledge about the functions of CD226, CD96, WUCAM and LFA-1 and their respective ligands, CD155, CD112, intercellular adhesion molecule (ICAM)-1 and junctional adhesion molecule (JAM)-1. The interactions of these receptors and their ligands are involved in many key functions of immune cells including naive T cells, cytotoxic T cells, NK cells, NK T cells, monocytes, dendritic cells, mast cells and platelets/megakaryocytes.
Xu
Zhuwei
Z
Department of Immunology, the Fourth Military Medical University, Xi'an, China. immu_jin@fmmu.edu.cn
Jin
Boquan
B
D000818:Animals; D015703:Antigens, CD / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*; D008024:Ligands; D011971:Receptors, Immunologic / Q000276:immunology; D015398:Signal Transduction
D015703:Antigens, CD; D007136:Immunoglobulins; D008024:Ligands; D011971:Receptors, Immunologic