title: Hypertriglyceridemia with increased plasma insulin concentrations in cats.
abstract: Metabolite, insulin and adiponectin concentrations and LDH, AST and ALT activities were measured in plasma of 142 client-owned cats (1-13years old, 16 breeds) to set up a new criterion of hypertriglyceridemia (hyper-TG) with increased plasma insulin concentrations for early diagnosis of lipid metabolism abnormality including obesity. 25 cats with over 165mg/dl of plasma triglyceride (TG) concentrations were decided as hyper-TG with increased plasma insulin concentrations, and prevalence of hyper-TG was 16.7% in young (1-6years old) and 18.3% in old (>7years old) cats examined. In the hyper-TG cats, their plasma TG concentrations increased to 6.6-7.4-fold of the values of control cats with 35-50mg/dl of plasma TG and their plasma cholesterol, FFA and insulin concentrations and LDH and ALT activities increased significantly, whereas their plasma adiponectin concentrations decreased significantly compared to those in the control cats. Hyper-TG cats with significantly increased body weights and plasma insulin and decreased plasma adiponectin seemed to be in early stage of obesity accompanying increased plasma insulin concentrations. Increased TG, insulin, LDH and ALT and decreased adiponectin values in plasma seemed to be key factors for diagnosis of lipid metabolism abnormality at early stage in cats.
authors.affiliation: School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hatano
authors.forename: N
authors.initials: N
authors.lastname: Mori
authors.forename: M
authors.initials: M
authors.lastname: Asada
authors.forename: A
authors.initials: A
authors.lastname: Mori
authors.forename: I
authors.initials: I
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Muranaka
authors.forename: M
authors.initials: M
authors.lastname: Kojima
authors.forename: M
authors.initials: M
authors.lastname: Kigure
authors.forename: M
authors.initials: M
authors.lastname: Yagishita
authors.forename: T
authors.initials: T
authors.lastname: Sako
authors.forename: T
authors.initials: T
authors.lastname: Arai
mesh_terms: D000375:Aging; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001835:Body Weight; D002415:Cats; D002784:Cholesterol / Q000097:blood; D006937:Hypercholesterolemia / Q000453:epidemiology / Q000662:veterinary; D015228:Hypertriglyceridemia / Q000201:enzymology / Q000378:metabolism* / Q000662:veterinary*; D007328:Insulin / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D009765:Obesity / Q000201:enzymology / Q000378:metabolism / Q000662:veterinary*; D012016:Reference Values
chemical_list: D007328:Insulin; D002784:Cholesterol; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase