Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity.
Polarized epithelial cells have a distinctive apical-basal axis of polarity for vectorial transport of ions and solutes across the epithelium. In contrast, migratory mesenchymal cells have a front-rear axis of polarity. During development, mesenchymal cells convert to epithelia by coalescing into aggregates that undergo epithelial differentiation. Signaling networks and protein complexes comprising Rho family GTPases, polarity complexes (Crumbs, PAR, and Scribble), and their downstream effectors, including the cytoskeleton and the endocytic and exocytic vesicle trafficking pathways, together regulate the distributions of plasma membrane and cytoskeletal proteins between front-rear and apical-basal polarity. The challenge is to understand how these regulators and effectors are adapted to regulate symmetry breaking processes that generate cell polarities that are specialized for different cellular activities and functions.
Nelson
W James
WJ
Department of Biology, Stanford University, Stanford, California 94305, USA. wjnelson@stanford.edu
D000818:Animals; D019521:Body Patterning; D002448:Cell Adhesion; D016764:Cell Polarity; D004023:Dictyostelium; D004705:Endocytosis; D004847:Epithelial Cells / Q000166:cytology*; D005089:Exocytosis; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D020741:rho GTP-Binding Proteins