title: Cardiac troponin I is released following high-intensity short-duration exercise in healthy humans.
abstract: It has been previously shown that cardiac troponin (cTn) is released in response to prolonged endurance exercise. The influence of short-duration high-intensity exercise upon the release of cTn is not known. We examined cardiac troponin I (cTnI) release pre-, during and post-30 min of high-intensity running exercise in eight recreationally active males (age 29±3 years; VO2peak 53±11 ml kg min(-1)). Following exercise, cTnI increased in six of the eight participants. Four participants showed a minimal response (<0.05 µg/l) post-exercise. In contrast, two participants showed a progressive increase in cTnI (>0.1 µg/l) following exercise which peaked 3-4 h post-exercise. cTnI returned below the detection limit of the assay in all bar one of the participants 24 h post-exercise. These data are the first to show that cTnI can be released following short-duration high-intensity exercise. Clinicians should be aware that exercise-induced release of cTnI is not limited to prolonged endurance activity.
authors.affiliation: Brunel University, Uxbridge, Middlesex, UK. Electronic address: rob.shave@brunel.ac.uk.
authors.forename: Rob
authors.initials: R
authors.lastname: Shave
authors.affiliation: Brunel University, Uxbridge, Middlesex, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Ross
authors.affiliation: Brunel University, Uxbridge, Middlesex, UK.
authors.forename: David
authors.initials: D
authors.lastname: Low
authors.affiliation: Liverpool John Moores University, Liverpool, UK.
authors.forename: Keith
authors.initials: K
authors.lastname: George
authors.affiliation: Brunel University, Uxbridge, Middlesex, UK; St. Georges Hospital Medical School NHS Trust, Tooting, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Gaze
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D012420:Running / Q000502:physiology*; D013997:Time Factors; D019210:Troponin I / Q000097:blood / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D019210:Troponin I