title: Burkholdines 1097 and 1229, potent antifungal peptides from Burkholderia ambifaria 2.2N.
abstract: Potent antifungal cyclic lipopeptides, burkholdines (Bk), were isolated from a culture of Burkholderia ambifaria 2.2N. Bk-1229 (1) and Bk-1097 (2) are octapeptides comprised of nonproteinogenic amino acids, including beta-hydroxytyrosine, beta-hydroxyasparagine, and a new fatty acyl amino acid. 1 and 2 are fungicidal against a panel of fungi with potencies 2-60-fold better than amphotericin B control.
authors.affiliation: Department of Pharmacognosy, Suez Canal University, Ismailia, Egypt 41522.
authors.forename: Kamilia A
authors.initials: KA
authors.lastname: Tawfik
authors.forename: Peter
authors.initials: P
authors.lastname: Jeffs
authors.forename: Brian
authors.initials: B
authors.lastname: Bray
authors.forename: George
authors.initials: G
authors.lastname: Dubay
authors.forename: Joseph O
authors.initials: JO
authors.lastname: Falkinham
authors.forename: Mostafa
authors.initials: M
authors.lastname: Mesbah
authors.forename: Diaa
authors.initials: D
authors.lastname: Youssef
authors.forename: Sherief
authors.initials: S
authors.lastname: Khalifa
authors.forename: Eric W
authors.initials: EW
authors.lastname: Schmidt
mesh_terms: D000528:Alternaria / Q000187:drug effects; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects; D020171:Botrytis / Q000187:drug effects; D019117:Burkholderia / Q000737:chemistry*; D055666:Lipopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D055750:Phytophthora infestans / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D055666:Lipopeptides; C000718065:burkholdine