Administration of neuraminidase inhibitors for the treatment of Japanese patients infected with the novel influenza A (H1N1).
The Centers for Disease Control and Prevention in the United States recommend the use of neuraminidase inhibitors for treating the novel influenza A (H1N1) in patients requiring desirable antiviral agents. However, the efficacy and side effects of neuraminidase inhibitors in Japanese patients infected with the novel influenza A (H1N1) are not well known. It is worth reporting on the results of the administration of neuraminidase inhibitors in Japanese patients infected with the novel influenza A (H1N1), as it is believed the number of Japanese patients will increase in the future. We treated seven Japanese patients (five adults and two juveniles) infected with the novel influenza A (H1N1) with oseltamivir and zanamivir, and good clinical courses were obtained. Our study indicates that oseltamivir and zanamivir may indeed be useful in Japanese patients infected with the novel influenza A (H1N1) in cases where antiviral therapy is required.
Ohnishi
Kenji
K
Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital, Tokyo, Japan. infection@bokutoh-hp.metro.tokyo.jp
Nakamura-Uchiyama
Fukumi
F
D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification / Q000187:drug effects*; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology; D007564:Japan; D008297:Male; D009439:Neuraminidase / Q000037:antagonists & inhibitors* / Q000494:pharmacology / Q000627:therapeutic use; D053139:Oseltamivir / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult; D053243:Zanamivir / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use
D000998:Antiviral Agents; D053139:Oseltamivir; D009439:Neuraminidase; D053243:Zanamivir