Synthesis and anti-human hepatocellular carcinoma activity of new nitric oxide-releasing glycosyl derivatives of oleanolic acid.
A series of nitric oxide (NO)-releasing glycosyl derivatives () of oleanolic acid were synthesized to improve the aqueous solubility and cytotoxicity of the parent compound . Derivative exhibited better solubility and strong cytotoxicity against human hepatocellular carcinoma (HCC) in vitro. Furthermore, displayed low acute toxicity to mice and significantly inhibited the growth of HCC tumors in vivo, indicating that may be a promising candidate for the treatment of human HCC.
Huang
Zhangjian
Z
Center of Drug Discovery, China Pharmaceutical University, Nanjing, PR China.
Zhang
Yihua
Y
Zhao
Li
L
Jing
Yongwang
Y
Lai
Yisheng
Y
Zhang
Luyong
L
Guo
Qinglong
Q
Yuan
Shengtao
S
Zhang
Jianjun
J
Chen
Li
L
Peng
Sixun
S
Tian
Jide
J
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D055808:Drug Discovery; D005260:Female; D006031:Glycosylation; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000737:chemistry*; D009828:Oleanolic Acid / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D012995:Solubility; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry; D023041:Xenograft Model Antitumor Assays
D000970:Antineoplastic Agents; D014867:Water; D009569:Nitric Oxide; D009828:Oleanolic Acid