[Developments in cancer care with innovative genomics. 2008 report of the National Cancer Consortium].
In the 3rd year of the program 8 new molecular diagnostic services have been introduced to clinic in the management of breast-, lung-, colorectal cancers as well as in GIST and melanoma. Two patents have been filed for innovative modulation of mito/motogenic signaling pathways in cancer cells. In preclinical models of human cancer a functional imaging technique was developed to detect vascular eff ects of erythropoietin. Using a genomic approach, the sequential changes in human melanoma during systemic dissemination were determined revealing several novel potential prognostic factors and some interesting novel targets for therapy.
Tímár
József
J
Országos Onkológiai Intézet Budapest Semmelweis Egyetem II. sz. Patológiai Intézet 1091 Budapest Ulloi út 93. jtimar@korb2.sote.hu
Kásler
Miklós
M
Heringh
Alexandra
A
Soós
Miklós
M
Mathiász
Dóra
D
Romány
Anna
A
Józsa
Adrienn
A
Szilák
László
L
Forrai
Tamás
T
Patthy
László
L
Kovács
Gábor
G
D000970:Antineoplastic Agents / Q000494:pharmacology*; D014408:Biomarkers, Tumor / Q000235:genetics*; D001859:Bone Neoplasms / Q000556:secondary; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D023281:Genomics; D006801:Humans; D006814:Hungary; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000235:genetics; D009369:Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D057089:Pathology, Molecular; D010597:Pharmacogenetics; D011379:Prognosis; D015397:Program Evaluation; D012307:Risk Factors; D015398:Signal Transduction / Q000235:genetics; D012878:Skin Neoplasms / Q000175:diagnosis / Q000235:genetics
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor