[Proteomics and biomarkers for detection of cervical cancer].
OBJECTIVE
The purpose of this study was to focus on recent developments in the rapidly evolving field of biomarker discovery and validation techniques using proteomics platform with respect to cervical cancer.


METHODS
Review.


METHODS
Department of Obstetrics and Gynecology Medical Faculty Charles University Hradec Kralove.


METHODS
The last decade has seen major changes in the technologies used to identify diagnostic markers for early stages of cervical cancer. Significant advances were achieved in three key areas: protein profilling, multidimensional liquid chromatography combined with cutting edge mass spectrometry and high-throughput validation techniques. These new technologies hold significant promise in identifying more robust, sensitive and specific markers for cervical cancer.


CONCLUSIONS
The present review summarizes the results of clinical and experimental research on biomarkers of cervical cancer.
Kacerovský
M
M
Lékarská fakulta Hradec Králové Univerzita Karlova Praha, Porodnická a gynekologická klinika FN Hradec Králové. kacermar@fnhk.cz
Tosner
J
J
D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D009363:Neoplasm Proteins / Q000032:analysis*; D040901:Proteomics / Q000379:methods*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins