[A mathematical model of the intracellular reproduction of the influenza virus].
A mathematical model of the intracellular reproduction of the influenza virus has been constructed, which describes the regulation of transcription, translation, replication, and assembly of the virus in a sensitive noninterferonogenic cell. A structural and parametric verification of the model has been performed, which involves an analysis of alternative mechanisms of regulation of the key events of the reproduction of the influenza virus at the stages of the primary and secondary transcription. It was shown that the dynamics of the concentrations of the system components is in qualitative agreement with the experimental data. An analysis of the model parameters showed a high sensitivity of the model to changes in the parameters that control the efficiency of the binding of the viral polymerase to virus-specific RNAs at the stages of initiation and elongation of transcription and replication of the viral genome. The results obtained suggest that the stages of the virus reproduction sensitive to changes in the parameters are potential targets for drugs. Using the model, a minimal multiplicity of infection at which the formation of viral particles is observed was predicted.
Bazhan
S I
SI
Kashevarova
N A
NA
Khlebodarova
T M
TM
Likhoshvaĭ
V A
VA
Kolchanov
N A
NA
D008954:Models, Biological; D009975:Orthomyxoviridae / Q000235:genetics / Q000502:physiology*; D014176:Protein Biosynthesis; D014158:Transcription, Genetic; D019065:Virus Assembly; D053586:Virus Internalization; D014779:Virus Replication