Scoring and monitoring the severity of psoriasis. What is the preferred method? What is the ideal method? Is PASI passé? facts and controversies.
Instruments to measure and to monitor the severity of psoriasis over time are needed for research and for optimal patient care. Scoring psoriasis has moved from an earlier time when clinical categories were adopted without concern about their reliability; for example, from clearance to more recent semi-quantitative scores, such as the Psoriasis Area and Severity Index (PASI), that carry the allure of being objective and quantitative "hard" data but actually translate a subjective judgement into a number. The PASI score has never been standardized, and data on interrater and intrarater reliability are limited. Better clinimetrics of disease severity are needed. The next generation of instruments should reflect the major concern of patients and treating physicians relative to safe and effective long-term disease control for a lifelong condition.
Naldi
Luigi
L
Centro Studi Gruppo Italiano Studi Epidemiologici in Dermatologia and Department of Dermatology, Ospedali Riuniti, Largo Barozzi 1, 24100 Bergamo, Italy. luigi.naldi@gised.it
D003879:Dermatologic Agents / Q000008:administration & dosage; D003880:Dermatology / Q000379:methods; D006801:Humans; D015233:Models, Statistical; D008962:Models, Theoretical; D011565:Psoriasis / Q000145:classification* / Q000175:diagnosis* / Q000188:drug therapy; D011788:Quality of Life; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012867:Skin / Q000473:pathology*
D003879:Dermatologic Agents