Antinociceptive and anti-inflammatory effects of ethanolic extracts of Glycine max (L.) Merr and Rhynchosia nulubilis seeds.
The aim of this study was to assess the in vivo potential of ethanolic extracts of Glycine max (L.) Merr. (SoRiTae) and Rhynchosia nulubilis (Yak-Kong) seeds as natural anti-nociceptive and anti-inflammatory agents. To assess the anti-nociceptive and anti-inflammatory potential, the ethanolic extracts of SoRiTae and Yak-Kong seeds were tested in arachidonic acid-induced ear edema, carrageenan induced paw edema, formalin-induced licking time, acetic acid induced writhing and hot plate-induced thermal stimulation in mice. The administration of ethanolic extracts of SoRiTae and Yak-Kong seeds evoked a significant effect of anti-nociceptive and anti-inflammatory activities as compared to standards aminopyrine and indomethacin. The ear edema, paw edema, paw licking time, pain and writhes in mice were significantly reduced (p < 0.05) as compared to the control. The results obtained in this study indicate that both SoRiTae and Yak-Kong soybeans possesses potential anti-nociceptive and anti-inflammatory activities.
Yim
Joo Hyuk
JH
Korea Food Research Institute, Seongnam, Kyonggi, 463-746, Korea.
Lee
Ok-Hwan
OH
Department of Biomedical Science, CHA University, Seongnam, Kyonggi, 463-836, Korea.
Choi
Ung-Kyu
UK
Pohang Center for Evaluation of Biomaterials, Pohang 790-834, Korea.
Kim
Young-Chan
YC
Korea Food Research Institute, Seongnam, Kyonggi, 463-746, Korea.
D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D000431:Ethanol / Q000737:chemistry; D007887:Fabaceae / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D010146:Pain / Q000188:drug therapy*; D059408:Pain Management; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D012639:Seeds / Q000737:chemistry / Q000378:metabolism; D013025:Glycine max / Q000737:chemistry* / Q000378:metabolism
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D000431:Ethanol