Autonomous silica encapsulation and sustained release of anticancer protein.
We present a novel method for preparing a silica carrier for the sustained release of a proteinaceous pharmaceutical. This method makes use of the silicification activity of the protein itself, which autonomously formed a protein-silica composite upon simple incubation with a silica precursor. The composite was dissolved, and the encapsulated protein was released into a culture medium, thereby sustaining the protein's activity for a long period of time.
Sano
Ken-ichi
K
Division of Protein Engineering, Cancer Institute, Japanese Foundation for Cancer Research, Koto, Tokyo 135-8550, Japan.
Minamisawa
Tamiko
T
Shiba
Kiyotaka
K
D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D008422:Materials Testing; D010316:Particle Size; D011506:Proteins / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
D004337:Drug Carriers; D011506:Proteins; D012822:Silicon Dioxide