title: Chemotherapy with low-dose capecitabine as palliative treatment in a patient with metastatic breast cancer: a case report.
abstract: Chemotherapeutic agents are rarely used for symptom management in patients under palliative care setting. This is because chemotherapeutic agents not only have limited efficacy in palliative treatment but are also known to exert severe adverse effects. We describe our experience with a patient with metastatic breast cancer who was successfully treated with low-dose capecitabine, without the development of any severe toxicities and with significant improvement in activities of daily living (ADL) and quality of life (QOL).The patient, a 43-year-old female, had breast cancer with liver, bone, and cutaneous metastases. She visited our clinic after a year-long hiatus during which she underwent alternative therapy. She presented with ulcerated lesions on the anterior chest and dyspnea due to malignant pleural effusion. After treatment for the latter, we administered capecitabine (600 mg/day) in accordance with the wishes of the patient and her attendants. The ulcerated lesions on the anterior chest, dyspnea, ADL and QOL improved significantly, without the development of any serious adverse effects. The findings of this case indicate that chemotherapy in the form of low-dose capecitabine monotherapy may be considered in patients under palliative care setting.
authors.affiliation: Department of Practical Pharmacy, School of Pharmacy, Tokyo University of Pharmacy & Life Sciences, 1432-1 Horinouchi, Hachioji-city, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: Satoru
authors.initials: S
authors.lastname: Iwase
authors.forename: Hironori
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Ayako
authors.initials: A
authors.lastname: Ikeda
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Kuroda
authors.forename: Naoko
authors.initials: N
authors.lastname: Sakata
authors.forename: Megumi
authors.initials: M
authors.lastname: Umeda
authors.forename: Kaori
authors.initials: K
authors.lastname: Kobara
authors.forename: Tadaharu
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Sakae
authors.initials: S
authors.lastname: Unezaki
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nagumo