[The curative effect of 1.8% hypertonic electrolyte glucose solution in enteral resuscitation of burn shock].
OBJECTIVE
To study the resuscitative effect of hypertonic electrolyte glucose solution (HEGS) in enteral resuscitation of burn shock.


METHODS
Eighteen Beagle dogs with 35% TBSA full-thickness flame injury were used in this study. They were randomized to a control group (no-fluid resuscitation, N group), a HEGS resuscitation group (H group) or an isotonic electrolyte glucose solution (IEGS) resuscitation group (I group). The solution enterally was given for resuscitation from half an hour after burn. The volumes and rates of fluid infusion in the H group were basically in accordance with 2 ml/(kg x 1%TBSA), those in the I group were basically in accordance with parkland formula [4 ml/(kg x 1%TBSA)]. The haemodynamic parameters, global end-diastolic volume index, plasma volume, osmotic pressure of plasma, intestinal absorptive rates of water and Na(+), and intestine mucosa blood flow were continuously assessed.


RESULTS
The cardiac output index, global end-diastolic volume index, plasma volume and intestine blood mucosa flow reduced markedly after burn in the three groups, and then gradually returned from 2 h after burn in two resuscitation groups, which were higher than that in the N group (P < 0.05). The activities of diamine oxidase in plasma in the two resuscitation groups were higher than that in N group (P < 0.05). The intestinal absorption rates of water and Na(+) reduced markedly after burn in two resuscitation groups with the lowest levels, and then returned from 6 h after burn. The rates of water in H group were lower than that in I group (P < 0.05); the rates of Na(+) in H group were higher than in I group (P < 0.05).


CONCLUSIONS
The results indicated that 35%TBSA III degrees burn-injury dogs be resuscitated effectively with 1.8% hypertonic electrolyte-glucose solution by enteral, which 1/2 volume of an isotonic electrolyte glucose solution.
Hu
Quan
Q
Burns Institute, First Hospital Affiliated to the PLA General Hospital, Beijing 100037, China.
Hu
Sen
S
Chai
Jia-ke
JK
Shen
Xiao-peng
XP
Che
Jin-wei
JW
Sheng
Zhi-yong
ZY
D000818:Animals; D002056:Burns / Q000628:therapy*; D004195:Disease Models, Animal; D004285:Dogs; D004750:Enteral Nutrition; D005440:Fluid Therapy / Q000379:methods*; D005950:Glucose Solution, Hypertonic / Q000008:administration & dosage* / Q000627:therapeutic use; D011897:Random Allocation; D012151:Resuscitation / Q000379:methods; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage* / Q000627:therapeutic use
D005950:Glucose Solution, Hypertonic; D012462:Saline Solution, Hypertonic