title: A novel approach to 3-methylindoles by a Heck/cyclization/isomerization process.
abstract: A novel synthesis of 3-methylindoles from chlorotriflates through a Heck reaction, carbamate/aryl chloride coupling, and isomerization sequence is presented. The three-step sequence is highly efficient and general, enabling the regiocontrolled synthesis of substituted indoles in short order.
authors.affiliation: Department of Process Research, Merck Sharp and Dohme Research Laboratories, Hertford Road, Hoddesdon, Hertfordshire, EN11 9BU, United Kingdom. carl_baxter2@merck.com
authors.forename: Carl A
authors.initials: CA
authors.lastname: Baxter
authors.forename: Ed
authors.initials: E
authors.lastname: Cleator
authors.forename: Mahbub
authors.initials: M
authors.lastname: Alam
authors.forename: Antony J
authors.initials: AJ
authors.lastname: Davies
authors.forename: Adrian
authors.initials: A
authors.lastname: Goodyear
authors.forename: Michael
authors.initials: M
authors.lastname: O'Hagan
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D012862:Skatole / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006843:Hydrocarbons, Chlorinated; D008698:Mesylates; D012862:Skatole