[COX-2 Inhibitors for the management of postoperative pain].
Compounds with anti-inflammatory properties are an important component of multimodal postoperative analgesia. NSAIDs and selective COX-2 inhibitors are of similar analgesic efficacy in this indication. However, the use of COX-2 inhibitors reduces the risk of gastrointestinal ulcers, bleeding complications and bronchospasm in comparison to NSAIDs. In parallel, COX-2 Inhibitors do not carry an increased risk of cardiovascular complications and require the same caution with regard to renal effects as NSAIDs.
Schug
Stephan A
SA
Universität von Westaustralien und Director of Pain Medicine at Royal Perth Hospital in Perth, Aus tralien - zurzeit als Gastprofessor am Universitätsklinikum Münster. stephan.schug@uwa.edu.au
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000453:epidemiology; D051546:Cyclooxygenase 2 / Q000502:physiology; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000453:epidemiology; D010149:Postoperative Pain / Q000188:drug therapy*; D012306:Risk
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D051546:Cyclooxygenase 2