Genetics of bronchopulmonary dysplasia in the age of genomics.
OBJECTIVE
According to recent evidence, susceptibility to bronchopulmonary dysplasia (BPD) in preterm infants is predominantly inherited. The purpose of this review is to discuss current published genetic association studies in light of the accumulated knowledge in genomics.


RESULTS
Major advances in the development of next-generation genotyping and sequencing platforms, statistical methodologies, inventories of functional outcome of some common genetic polymorphisms and large-scale cataloguing of genetic variability among many of the world's ethnic populations have greatly facilitated the study of polygenic conditions. For BPD, genetic-association studies have primarily focused on components of innate (e.g. first-line) immune and antioxidant defences, mechanisms of vascular and lung remodelling, and surfactant proteins. However, studies have been limited in sample size and therefore fraught with a high probability of false-positive and false-negative associations. Nonetheless, candidate gene associations have indicated some novel biological pathways and provide a conceptual framework for the design of larger, collaborative population-based studies.


CONCLUSIONS
Although studies to date have not been able to identify reproducible genetic risk markers for BPD, they have directed us towards new, promising research avenues.
Lavoie
Pascal M
PM
Child & Family Research Institute, University of British Columbia, Vancouver, Canada. plavoie@cw.bc.ca
Dubé
Marie-Pierre
MP
D001997:Bronchopulmonary Dysplasia / Q000235:genetics*; D023281:Genomics; D006801:Humans; D007231:Infant, Newborn