Immunohistochemical expression of HER-2/NEU-CERBB-2 in patients with adenocarcinoma of the stomach.
OBJECTIVE
To determine the prevalence of Her-2/Neu-cerbb-2 in the gastric mucosa of patients with gastric adenocarcinoma in a brazilian patient group.


METHODS
The immunohistochemical expression of Her-2/Neu was studied in 37 formalin-fixed paraffin-embedded tissue sections.


RESULTS
The immunohistochemical reaction produced by the anti-HER-2/Neu antibody was positive in two cases (5.4%).


CONCLUSIONS
The low prevalence of Her-2/Neu observed in these southern brazilian cases is probably due to the great number of poorly differentiated cancers in this series.
Cirne-Lima
Fernando K
FK
Federal University of Rio Grande do Sul, Porto Alegre, RS, Brasil. bruce@cpovo.net
Rosa
Aline de Souza
Ade S
Kulczynski
Jane M U
JM
Mattana
Diego S
DS
Corezolla
Kizzy
K
Moreira
Luis F
LF
D000230:Adenocarcinoma / Q000737:chemistry / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics*; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000737:chemistry / Q000235:genetics*
D018719:Erb-b2 Receptor Tyrosine Kinases