title: Could aging human skin use a connective tissue growth factor boost to increase collagen content?
abstract: The roles of connective tissue growth factor (CTGF) and transforming growth factor-beta (TGF-beta), both well-known collagen production stimulators, were examined in skin aging. Aged skin and fibroblasts exhibited a coordinate decrease in CTGF, TGF-beta, and type I procollagen expression and content. CTGF knockdown and TGF-beta blockade in normal dermal fibroblasts reduced procollagen expression, whereas overexpressing CTGF increased procollagen by a TGF-beta/Smad signaling-dependent mechanism without involving Smad2/3.
authors.affiliation: Therapeutics Research, FibroGen, Inc., San Francisco, California 94080, USA. noelynnoliver@yahoo.com
authors.forename: Noelynn
authors.initials: N
authors.lastname: Oliver
authors.forename: Mark
authors.initials: M
authors.lastname: Sternlicht
authors.forename: Karin
authors.initials: K
authors.lastname: Gerritsen
authors.forename: Roel
authors.initials: R
authors.lastname: Goldschmeding
mesh_terms: D000818:Animals; D003094:Collagen / Q000737:chemistry / Q000378:metabolism*; D055513:Connective Tissue Growth Factor / Q000378:metabolism*; D003880:Dermatology / Q000379:methods; D005347:Fibroblasts / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D012867:Skin / Q000378:metabolism; D015595:Skin Aging; D051785:Smad Proteins / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D051785:Smad Proteins; D016212:Transforming Growth Factor beta; D055513:Connective Tissue Growth Factor; D003094:Collagen