Tipping the scale: muscle versus fat.
Adipocytes and scar tissue form during skeletal muscle degeneration. Two new studies reveal that adipocytes and fibroblasts in skeletal muscle derive from a population of bipotent progenitors that reside within muscle, but are not derived from the muscle lineage. These progenitor cells also have a surprising role in stimulating the restoration of muscle mass during regeneration.
Rodeheffer
Matthew S
MS
Section of Comparative Medicine, Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA. matthew.rodeheffer@yale.edu
D017667:Adipocytes / Q000166:cytology* / Q000378:metabolism; D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D005347:Fibroblasts / Q000166:cytology; D051379:Mice; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000166:cytology*; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism