Fluorescence properties and cellular distribution of the investigational anticancer drug triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex.
Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), which entered several phase I and II clinical trials as an antitumor chemotherapeutic agent, was found to possess intrinsic fluorescence properties (lambda(ex) = 360 nm), which enabled us to monitor the uptake and intracellular distribution in living human cancer cells by fluorescence microscopy.
Kowol
Christian R
CR
University of Vienna, Institute of Inorganic Chemistry, Währingerstr. 42, A-1090, Vienna, Austria.
Trondl
Robert
R
Arion
Vladimir B
VB
Jakupec
Michael A
MA
Lichtscheidl
Irene
I
Keppler
Bernhard K
BK
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005453:Fluorescence; D006801:Humans; D008856:Microscopy, Fluorescence; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry*; D013882:Thiosemicarbazones / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D011725:Pyridines; D013882:Thiosemicarbazones; C078157:3-aminopyridine-2-carboxaldehyde thiosemicarbazone; D015032:Zinc