Induction of tolerance to warfarin after anaphylaxis with a desensitization protocol.
Warfarin hypersensitivity is exceedingly rare. A 59-year-old male with acute renal infarction and a history of allergy to warfarin underwent evaluation, confirming presence of warfarin hypersensitivity. Induction of tolerance to warfarin was successfully completed using an oral desensitization protocol, which has not previously been reported.
Jameson
Travis
T
Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, USA.
Siri
Dareen
D
D000284:Administration, Oral; D000707:Anaphylaxis / Q000139:chemically induced* / Q000276:immunology* / Q000517:prevention & control; D000925:Anticoagulants / Q000008:administration & dosage / Q000276:immunology* / Q000633:toxicity*; D003888:Desensitization, Immunologic / Q000379:methods*; D003875:Drug Eruptions / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007238:Infarction / Q000150:complications; D007668:Kidney / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013923:Thromboembolism / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology / Q000517:prevention & control; D014859:Warfarin / Q000008:administration & dosage / Q000276:immunology* / Q000633:toxicity*
D000925:Anticoagulants; D014859:Warfarin