title: [Development of Ethylcellulose/Eudragit matrix for controlled and continuous release of insulin].
abstract: OBJECTIVE
  Diabetes Type I is a chronic disease requiring insulin repeated injections by parenteral during a lifetime. This method of administration as well as traumatic can be a problem for adherence of patients to treatment. In order to overcome these difficulties, we considered the development of therapeutic transdermal drug delivery (TTDD) of insulin.
  
  
  METHODS
  As active ingredient we used anhydrous human insulin Actarapid HM from Novo Nordisk laboratory, the excipients are ethyl cellulose, Eudragit RS 100 and butylphtalate. We developed two matrix Ethylcellulose/Eudragit in reports 1 and 2, in which are incorporated different proportions of insulin.
  
  
  RESULTS
  The study of the release of insulin in phosphate buffer at pH 7.4, showed a continuous release profiles strongly depending on Ethylcellulose/Eudragit report and the initial charge of insulin.
  
  
  CONCLUSIONS
  This study shows that the matrix Ethylcellulose/Eudragit lends itself to the development of a controlled release of insulin. This allows us to continue this work by combining this matrix with other elements for achieving an insulin TTDD.
authors.affiliation: Laboratoire de Biophysique et de Physique Pharmaceutique, Faculté de Médecine de Pharmacie et d’Odontologie de Dakar, Université Cheikh Anta Diop de Dakar. mbaygo@yahoo.fr
authors.forename: Gora
authors.initials: G
authors.lastname: Mbaye
authors.forename: Augustin
authors.initials: A
authors.lastname: Ndiaye
authors.forename: Louis Augustin Diaga
authors.initials: LA
authors.lastname: Diouf
authors.forename: Abdoulaye Séga
authors.initials: AS
authors.lastname: Diallo
authors.forename: Adama
authors.initials: A
authors.lastname: Diedhiou
authors.forename: Mbaye
authors.initials: M
authors.lastname: Sene
authors.forename: Mamadou
authors.initials: M
authors.lastname: Mbodj
authors.forename: Oumar
authors.initials: O
authors.lastname: Thioune
authors.forename: Amadou Moctar
authors.initials: AM
authors.lastname: Dieye
authors.forename: Ibrahima
authors.initials: I
authors.lastname: Diop
authors.forename: Aynina
authors.initials: A
authors.lastname: Cisse
authors.forename: Mounibé
authors.initials: M
authors.lastname: Diarra
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives; D016503:Drug Delivery Systems; D007328:Insulin / Q000008:administration & dosage*; D011109:Polymethacrylic Acids
chemical_list: D007328:Insulin; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; C013517:ethyl cellulose; D002482:Cellulose