Development of in vivo tooth EPR for individual radiation dose estimation and screening.
The development of in vivo EPR has made it feasible to perform tooth dosimetry measurements in situ, greatly expanding the potential for using this approach for immediate screening after radiation exposures. The ability of in vivo tooth dosimetry to provide estimates of absorbed dose has been established through a series of experiments using unirradiated volunteers with specifically irradiated molar teeth placed in situ within gaps in their dentition and in natural canine teeth of patients who have completed courses of radiation therapy for head and neck cancers. Multiple measurements in patients who have received radiation therapy demonstrate the expected heterogeneous dose distributions. Dose-response curves have been generated using both populations and, using the current methodology and instrument, the standard error of prediction based on single 4.5-min measurements is approximately 1.5 Gy for inserted molar teeth and between 2.0 and 2.5 Gy in the more irregularly shaped canine teeth. Averaging of independent measurements can reduce this error significantly to values near 1 Gy. Developments to reduce these errors are underway, focusing on geometric optimization of the resonators, detector positioning techniques, and optimal data averaging approaches. In summary, it seems plausible that the EPR dosimetry techniques will have an important role in retrospective dosimetry for exposures involving large numbers of individuals.
Williams
Benjamin B
BB
Dartmouth Medical School, 704 Vail HP7785, Hanover, NH 03755, USA.
Dong
Ruhong
R
Kmiec
Maciej
M
Burke
Greg
G
Demidenko
Eugene
E
Gladstone
David
D
Nicolalde
Roberto J
RJ
Sucheta
Artur
A
Lesniewski
Piotr
P
Swartz
Harold M
HM
D000818:Animals; D001681:Biological Assay / Q000379:methods*; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D008403:Mass Screening / Q000379:methods; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014070:Tooth / Q000737:chemistry* / Q000528:radiation effects*