title: Highly specific dual enzyme-mediated payload release from peptide-coated silica particles.
abstract: Stimuli-responsive gate mechanisms offer potential for the controlled passage of payload molecules from a porous carrier vehicle on-demand. We describe a method for the enzyme-mediated release of macromolecular guest molecules from inorganic silica particles coated with a bioactive peptide shell, synthesized precisely by Fmoc chemistry. Specific enzymatic hydrolysis of the peptide shell removes the bulky peptide-terminated Fmoc groups, permitting the selective release of previously entrapped guest molecules.
authors.affiliation: School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Thornton
authors.forename: Andreas
authors.initials: A
authors.lastname: Heise
mesh_terms: D000588:Amines / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D002918:Chymotrypsin / Q000378:metabolism*; D003911:Dextrans / Q000737:chemistry / Q000378:metabolism; D006868:Hydrolysis; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D010880:Piperidines / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D013379:Substrate Specificity; D013820:Thermolysin / Q000378:metabolism*
chemical_list: D000588:Amines; D003911:Dextrans; D010455:Peptides; D010880:Piperidines; C032727:piperidine; D012822:Silicon Dioxide; D002918:Chymotrypsin; D013820:Thermolysin