Comparison of oral glucose insulin sensitivity with other insulin sensitivity surrogates from oral glucose tolerance tests in Chinese.
BACKGROUND
There is no single method of measuring insulin resistance that is both accurate and can be easily performed by general researchers. We validate the accuracy of oral glucose insulin sensitivity (OGIS) in the Chinese by comparing the OGIS120 and OGIS180, homeostasis model assessment of insulin resistance (HOMA-IR), and quantitative insulin sensitivity check index (OUICKI) with steady-state plasma glucose (SSPG) in different glucose tolerance subjects.


METHODS
We enrolled 515 subjects, aged between 20 and 75 years old, during routine health evaluations. All subjects were divided into normal, obese, impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and type 2 diabetes (T2D) groups. Participants had a 3-hour oral glucose tolerance test (OGTT) and SSPG with an insulin suppression test. The relationships between SSPG and OGIS120, OGIS180, HOMA-IR, and QUICKI were evaluated.


RESULTS
The normal group had the highest OGIS120, OGIS180 and lowest SSPG as compared with the other 4 groups. OGIS180, HOMA-IR and QUICKI in all 5 groups were significantly related to SSPG (r = 0.397-0.621, all P <0.05). OGIS120 in all 5 groups was not significantly related to SSPG (r = 0.003-0.226). Additionally, the r value of OGIS180 against SSPG was not higher than the other 2 insulin sensitivity surrogates from OGTT.


CONCLUSIONS
Although OGIS180 was more accurate in estimating insulin sensitivity than OGIS120 in the Chinese, it was not superior to the traditional surrogates such as HOMA-IR or QUICKI.
Wu
Chung Ze
CZ
Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei,Taiwan, Republic of China.
Pei
Dee
D
Su
Ching Chieh
CC
Hsiao
Fone Ching
FC
Chu
Yi Min
YM
Lee
Li Hsiu
LH
Wang
Kun
K
Hsieh
An Tsz
AT
Lin
Juinn Diann
JD
Hsia
Te Lin
TL
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002681:China; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000175:diagnosis*; D055815:Young Adult