title: Neonatal lupus erythematosus: three case reports and review of the Chinese literature.
abstract: To recognize the clinical characteristics and outcomes of neonatal lupus erythematosus (NLE), the authors retrospectively review 3 NLE babies in their department and compared their data with 51 NLE cases reported in the available Chinese literature between January 1991 and December 2008. Most of the cases were located near the eastern coast of China, and clinical manifestation of 72.22% of the cases occurred in 2-week-old babies. Skin findings occurred in 94.44% of the patients, 12.96% with complete heart block (CHB), 22.22% with thrombocytopenia, and 14.81% with transient elevated transaminase levels. Cutaneous lesions, thrombocytopenia, and transaminase level showed improvement; 3 CHB cases had persisted after 7 to 10 years follow-up, and 1 case died in 5 months. Twenty-four (44.44%) pregnant woman with anti-Ro/SSA and/or anti-La/SSB antibodies are asymptomatic, and antibody status is first indicated when their child shows symptoms of NLE. Thus, all pregnant women should be screened for anti-Ro/ SSA and anti-La/SSB antibodies.
authors.affiliation: Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
authors.lastname: Wei Sun
authors.forename: Tian-Ming
authors.initials: TM
authors.lastname: Yuan
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Chen
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Yu
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis / Q000276:immunology; D002681:China; D005260:Female; D006327:Heart Block / Q000151:congenital* / Q000503:physiopathology; D006330:Heart Defects, Congenital / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D008178:Lupus Erythematosus, Cutaneous / Q000151:congenital / Q000276:immunology / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000151:congenital* / Q000276:immunology / Q000503:physiopathology; D008297:Male; D008431:Maternal-Fetal Exchange; D015997:Neonatal Screening; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D011379:Prognosis; D035583:Rare Diseases; D018570:Risk Assessment
chemical_list: D000974:Antibodies, Antinuclear; C035356:SS-A antibodies; C035357:SS-B antibodies