title: Recent research on polyphenolics in vision and eye health.
abstract: A long-standing yet controversial bioactivity attributed to polyphenols is their beneficial effects in vision. Although anecdotal case reports and in vitro research studies provide evidence for the visual benefits of anthocyanin-rich berries, rigorous clinical evidence of their benefits is still lacking. Recent in vitro studies demonstrate that anthocyanins and other flavonoids interact directly with rhodopsin and modulate visual pigment function. Additional in vitro studies show flavonoids protect a variety of retinal cell types from oxidative stress-induced cell death, a neuroprotective property of significance because the retina has the highest metabolic rate of any tissue and is particularly vulnerable to oxidative injury. However, more information is needed on the bioactivity of in vivo conjugates and the accumulation of flavonoids in ocular tissues. The direct and indirect costs of age-related vision impairment provide a powerful incentive to explore the potential for improved vision health through the intake of dietary polyphenolics.
authors.affiliation: Atlantic Food and Horticulture Research Centre, Agriculture and Agri-Food Canada, Kentville, Nova Scotia, Canada. wilhelmina.kalt@agr.gc.ca
authors.forename: Wilhelmina
authors.initials: W
authors.lastname: Kalt
authors.forename: Anne
authors.initials: A
authors.lastname: Hanneken
authors.forename: Paul
authors.initials: P
authors.lastname: Milbury
authors.forename: Francois
authors.initials: F
authors.lastname: Tremblay
mesh_terms: D000818:Animals; D035843:Biomedical Research; D005123:Eye / Q000187:drug effects* / Q000503:physiopathology; D005419:Flavonoids / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D006801:Humans; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D059808:Polyphenols; D014785:Vision, Ocular / Q000187:drug effects*
chemical_list: D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols