title: Contact lens-induced regression of Lisch epithelial corneal dystrophy.
abstract: OBJECTIVE
  To describe the use of soft contact lenses (CL) to reduce the epithelial opacities of Lisch epithelial corneal dystrophy (LECD). First presentation of confocal microscopy in LECD.
  
  
  METHODS
  Two unrelated female patients with LECD demonstrated a central gray opacity with distinct visual impairment. The first patient wore a daily hydroxyethlmethacrylate (HEMA) CL for 3 months and the second, a daily silicone hydrogel CL for 1 month. Pre-CL and post-CL appearances of the cornea were photodocumented at the slit lamp. Additionally, in the second patient, a confocal microscopic evaluation of LECD was performed.
  
  
  RESULTS
  In both patients, the wearing of CL resulted in a distinct reduction of central corneal opacification with a visual improvement. Discontinued wearing of CL induced again a progression of opacity. The confocal microscopy disclosed the typical intracytoplasmatic vacuolization of the involved epithelial cells.
  
  
  CONCLUSIONS
  Wearing CL for a longer duration causes a significant regression of corneal opacities in LECD. The etiology of this phenomenon is interpreted as a CL-induced thinning of corneal epithelium and reduction of epithelial layers.
authors.affiliation: Department of Ophthalmology, Klinikum Hanau, Hanau, Germany. Lisch.Hanau@t-online.de
authors.forename: Walter
authors.initials: W
authors.lastname: Lisch
authors.forename: Joanna
authors.initials: J
authors.lastname: Wasielica-Poslednik
authors.forename: Christina
authors.initials: C
authors.lastname: Lisch
authors.forename: Parykshit
authors.initials: P
authors.lastname: Saikia
authors.forename: Susanne
authors.initials: S
authors.lastname: Pitz
mesh_terms: D000328:Adult; D000368:Aged; D003263:Contact Lenses, Hydrophilic; D003317:Corneal Dystrophies, Hereditary / Q000473:pathology / Q000628:therapy*; D003318:Corneal Opacity / Q000473:pathology / Q000628:therapy; D019573:Epithelium, Corneal / Q000473:pathology*; D005260:Female; D006801:Humans; D008689:Methacrylates; D018613:Microscopy, Confocal; D020034:Silicone Gels; D014792:Visual Acuity
chemical_list: D008689:Methacrylates; D020034:Silicone Gels; C005044:hydroxyethyl methacrylate