[Role of xenobiotic biotransformation enzymes in respiratory diseases caused by dust].
Genetic peculiarities particularly xenobiotic detoxification enzymes play important role in pulmonary diseases development. The study was aimed to analyze gene polymorphisms for first (CYP1A1, CYP2E1, EPHX1) and second (GSTM1, GSTT1) phases of xenobiotics biotransformation in relation to occupational respiratory diseases risk.
Mingazova
S R
SR
Viktorova
T V
TV
Akhmadishina
L Z
LZ
D000328:Adult; D001711:Biotransformation / Q000235:genetics*; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics; D004247:DNA / Q000235:genetics; D004391:Dust; D004851:Epoxide Hydrolases / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D009784:Occupational Diseases / Q000201:enzymology* / Q000235:genetics; D016273:Occupational Exposure / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D011379:Prognosis; D012140:Respiratory Tract Diseases / Q000201:enzymology* / Q000235:genetics; D012307:Risk Factors; D015262:Xenobiotics / Q000009:adverse effects* / Q000378:metabolism
D019363:Cytochrome P-450 CYP1A1; D019392:Cytochrome P-450 CYP2E1; D004247:DNA; D004391:Dust; D004851:Epoxide Hydrolases; D005982:Glutathione Transferase; D015262:Xenobiotics; C413545:glutathione S-transferase T1; C522330:EPHX1 protein, human