title: Surgical and medical treatment of hearing loss in mixed otosclerosis.
abstract: OBJECTIVE
  We assessed the effect of using preoperative sodium fluoride (NaF) on the difficulty of working with the footplate during stapedectomy and its effect on the postsurgical hearing gain in patients with mixed otosclerosis (i.e., otosclerosis and/or otospongiosis).
  
  
  METHODS
  There were 2 groups of patients with mixed otosclerosis. The experimental group was made up of patients with an active focus of the disease; they received NaF for 6 months and then underwent stapedectomy. The control group was made up of patients with an inactive focus of the disease; they underwent stapedectomy without administration of NaF.
  
  
  RESULTS
  The difference between the study groups in the degree of difficulty in extracting the footplate was not found to be statistically significant. Both groups had hearing gains in bone and air conduction. The level of posttreatment hearing gain in the group exposed to NaF was greater than that in the nonexposed group.
  
  
  CONCLUSIONS
  Sodium fluoride administered to patients with mixed otosclerosis and an active focus of disease does not increase the difficulty of working with the footplate during stapedectomy, and it increases the hearing gain after the procedure.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, General Hospital of the National Medical Center La Raza, Mexican Institute of Social Security Mexico, DF, Mexico.
authors.forename: Manuel Martín
authors.initials: MM
authors.lastname: Félix-Trujillo
authors.forename: Edith
authors.initials: E
authors.lastname: Valdez-Martínez
authors.forename: Jorge Eduardo
authors.initials: JE
authors.lastname: Ramírez
authors.forename: Ramón
authors.initials: R
authors.lastname: Lozano-Morales
mesh_terms: D000328:Adult; D001844:Bone Conduction; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005276:Fenestration, Labyrinth; D005500:Follow-Up Studies; D034381:Hearing Loss / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010040:Otosclerosis / Q000150:complications / Q000188:drug therapy* / Q000601:surgery*; D020127:Recovery of Function; D012969:Sodium Fluoride / Q000008:administration & dosage*; D013201:Stapes Surgery; D016896:Treatment Outcome
chemical_list: D012969:Sodium Fluoride