title: [Hereditary tylosis syndrome and esophagus cancer].
abstract: Tylosis palmoplantaris is an autosomal dominant disorder characterized by hyperkeratosis of palms and soles. Lesions start during childhood and are more evident in areas of pressure. Familial tylosis palmoplantaris comprises two forms: epidermolytic and non-epidermolytic. Patients with the epidermolytic variant have up to 40% higher chance of developing squamous cell carcinoma of the esophagus. The association of tylosis palmoplantaris with esophageal cancer is called Howel-Evans syndrome.
authors.affiliation: Faculdade de Medicina do Vale do Aço, Ipatinga, MG, Brasil. kkmedicina@yahoo.com.br
authors.forename: Camila Alves
authors.initials: CA
authors.lastname: de Souza
authors.forename: Allan da Costa
authors.initials: Ada C
authors.lastname: Santos
authors.forename: Lennon da Costa
authors.initials: Lda C
authors.lastname: Santos
authors.forename: Artur Leonel
authors.initials: AL
authors.lastname: Carneiro
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D004938:Esophageal Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D015776:Keratoderma, Palmoplantar, Diffuse / Q000150:complications* / Q000235:genetics