title: Experimental and computational aspects of signaling mechanisms of spike-timing-dependent plasticity.
abstract: STDP (spike-timing-dependent synaptic plasticity) is thought to be a synaptic learning rule that embeds spike-timing information into a specific pattern of synaptic strengths in neuronal circuits, resulting in a memory. STDP consists of bidirectional long-term changes in synaptic strengths. This process includes long-term potentiation and long-term depression, which are dependent on the timing of presynaptic and postsynaptic spikings. In this review, we focus on computational aspects of signaling mechanisms that induce and maintain STDP as a key step toward the definition of a general synaptic learning rule. In addition, we discuss the temporal and spatial aspects of STDP, and the requirement of a homeostatic mechanism of STDP in vivo.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Urakubo
authors.forename: Minoru
authors.initials: M
authors.lastname: Honda
authors.forename: Keiko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Shinya
authors.initials: S
authors.lastname: Kuroda