title: Synthesis, characterization, and cytotoxic activity of novel platinum (II) complexes derived from n-benzyl-ethylenediamine and oxalate.
abstract: This work describes the synthesis and characterization of three novel complexes derived from N-benzyl-ethylenediamine and oxalate. Precursor compounds were synthesized by reacting N-benzyl-ethylenediamine with K(2)PtCl(4). Subsequent substitution of chlorides by oxalate led to the final products. Elemental analysis and the infrared, (1)H, (13)C, and (195)Pt NMR spectra of these complexes were provided. The cytotoxic activities were investigated against human non-small cell lung carcinoma (A(549)), mouse non-metastatic cell skin melanoma (B16-F1), mouse metastatic cell skin melanoma (B16-F10), human cell breast adenocarcinoma (MDA-MB-231) and normal cell lines such as baby hamster cell kidney (BHK-21), hamster cell ovary (CHO) and compared to cisplatin and carboplatin under the same experimental conditions. The presence of oxalate as a leaving group conferred an interesting cytotoxicity profile to the complexes in the tested cell lines.
authors.affiliation: Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora-MG, 36036-900, Brazil.
authors.forename: Heveline
authors.initials: H
authors.lastname: Silva
authors.forename: Carolina V
authors.initials: CV
authors.lastname: Barra
authors.forename: Fillipe V
authors.initials: FV
authors.lastname: Rocha
authors.forename: Mauro V
authors.initials: MV
authors.lastname: de Almeida
authors.forename: Eloi T
authors.initials: ET
authors.lastname: Cesar
authors.forename: Luciana M
authors.initials: LM
authors.lastname: da Silva Siqueira
authors.forename: Miriam T P
authors.initials: MT
authors.lastname: Lopes
authors.forename: Ana P S
authors.initials: AP
authors.lastname: Fontes
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D016466:CHO Cells; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D006224:Cricetinae; D003412:Cricetulus; D005029:Ethylenediamines / Q000737:chemistry*; D006801:Humans; D051379:Mice; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D010070:Oxalates / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D005029:Ethylenediamines; D009944:Organoplatinum Compounds; D010070:Oxalates; C031234:ethylenediamine