Topography mapping of whole body adipose tissue using A fully automated and standardized procedure.
OBJECTIVE
To obtain quantitative measures of human body fat compartments from whole body MR datasets for the risk estimation in subjects prone to metabolic diseases without the need of any user interaction or expert knowledge.


METHODS
Sets of axial T1-weighted spin-echo images of the whole body were acquired. The images were segmented using a modified fuzzy c-means algorithm. A separation of the body into anatomic regions along the body axis was performed to define regions with visceral adipose tissue present, and to standardize the results. In abdominal image slices, the adipose tissue compartments were divided into subcutaneous and visceral compartments using an extended snake algorithm. The slice-wise areas of different tissues were plotted along the slice position to obtain topographic fat tissue distributions.


RESULTS
Results from automatic segmentation were compared with manual segmentation. Relatively low mean deviations were obtained for the class of total tissue (4.48%) and visceral adipose tissue (3.26%). The deviation of total adipose tissue was slightly higher (8.71%).


CONCLUSIONS
The proposed algorithm enables the reliable and completely automatic creation of adipose tissue distribution profiles of the whole body from multislice MR datasets, reducing whole examination and analysis time to less than half an hour.
Würslin
Christian
C
Department of Diagnostic and Interventional Radiology, University of Tübingen, Tübingen, Germany. christian.wuerslin@med.uni-tuebingen.de
Machann
Jürgen
J
Rempp
Hansjörg
H
Claussen
Claus
C
Yang
Bin
B
Schick
Fritz
F
D000273:Adipose Tissue / Q000033:anatomy & histology*; D000465:Algorithms; D001185:Artificial Intelligence; D050218:Body Fat Distribution / Q000379:methods* / Q000592:standards; D005858:Germany; D006801:Humans; D007089:Image Enhancement / Q000379:methods / Q000592:standards; D007090:Image Interpretation, Computer-Assisted / Q000379:methods* / Q000592:standards; D021621:Imaging, Three-Dimensional / Q000379:methods* / Q000592:standards; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D051598:Whole Body Imaging / Q000379:methods* / Q000592:standards