Dammarane-type glycosides from Gynostemma pentaphyllum and their effects on IL-4-induced eotaxin expression in human bronchial epithelial cells.
Two new dammarane-type glycosides, 2alpha,3beta,12beta,20S-tetrahydroxydammar-24-ene-3-O-[beta-d-glucopyranosyl(1-->4)-beta-d-glucopyranosyl]-20-O-[beta-d-xylopyranosyl-(1-->6)-beta-d-glucopyranoside] (1) and 2alpha,3beta,12beta,20S-tetrahydroxydammar-24-ene-3-O-beta-d-glucopyranosyl-20-O-[beta-d-6-O-acetylglucopyranosyl-(1-->2)-beta-d-glucopyranoside] (2), were isolated from a MeOH extract of the leaves of Gynostemma pentaphyllum. Their structures were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical studies. The isolated compounds showed potential inhibitory effects on eotaxin expression in BEAS-2B bronchial epithelial cells.
Hung
Tran Manh
TM
College of Pharmacy, Catholic University of Daegu, Kyeongbuk 712-702, Korea.
Thu
Cao Van
CV
Cuong
To Dao
TD
Hung
Nguyen Phi
NP
Kwack
Seung Jun
SJ
Huh
Jung-Im
JI
Min
Byung Sun
BS
Choi
Jae Sue
JS
Lee
Hyeong Kyu
HK
Bae
KiHwan
K
D001980:Bronchi / Q000166:cytology / Q000187:drug effects; D004847:Epithelial Cells / Q000187:drug effects; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029774:Gynostemma / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014744:Vietnam; D000097669:Dammaranes
D005960:Glucosides; D006027:Glycosides; D014315:Triterpenes; D000097669:Dammaranes; C548100:2alpha,3beta,12beta,20S-tetrahydroxydammar-24-ene-3-O-(beta-D-glucopyranosyl(1-4)-beta-D-glucopyranosyl)-20-O-(beta-D-xylopyranosyl-(1-6)-beta-D-glucopyranoside); C548101:2alpha,3beta,12beta,20S-tetrahydroxydammar-24-ene-3-O-beta-D-glucopyranosyl-20-O-(beta-D-6-O-acetylglucopyranosyl-(1-2)-beta-D-glucopyranoside)