Exercise training in rats impairs the replenishment of white adipose tissue after partial lipectomy.
The aim of this study was to evaluate the effect of exercise training on the metabolism of rats following the partial removal of fat pads. Three-month-old male Wistar rats were subjected to the partial removal (L) of retroperitoneal white adipose tissue (RET) and epididymal white adipose tissue (EPI), or a sham operation (Sh). Seven days after surgery, both sets of rats were subdivided into exercised (LE or ShE) (swimming 90 min/day, 5 days/week, 6 weeks) and sedentary (LS or ShS) groups. Partial removal of the fat pads increased the lipogenesis rates in both the RET and EPI and decreased the weight and lypolysis rate of the EPI, while the RET weight was not significantly affected by lipectomy. In both lipectomized and sham-operated groups, exercise training caused a reduction in carcass lipid content, food intake, RET and EPI weights, and RET lipogenesis rate. On the other hand, the exercise training increased the percentage of diet-derived lipid accumulation in both tissues, either in sham and lipectomized rats. These results confirmed that regrowth is not uniform and depends on the particular fat pad that is excised. They also demonstrated that exercise training following the partial removal of fat pads modified adipose tissue metabolism, impaired the replenishment of adipose tissue, and decrease body adiposity.
Habitante
Carlos A
CA
Institute of Biological and Health Science, Universidade Federal do Mato Grosso, Mato Grosso, MT, Brazil.
Oyama
Lila M
LM
Bueno
Allain Amador
AA
Ribeiro
Eliane Beraldi
EB
Estadella
Débora
D
Dâmaso
Ana R
AR
Nascimento
Claudia M Oller do
CM
D050154:Adiposity; D000818:Animals; D004041:Dietary Fats / Q000378:metabolism; D004435:Eating; D050152:Intra-Abdominal Fat / Q000254:growth & development / Q000378:metabolism / Q000601:surgery*; D015187:Lipectomy; D050155:Lipogenesis; D008066:Lipolysis; D008297:Male; D009929:Organ Size; D005082:Physical Exertion; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration; D050151:Subcutaneous Fat / Q000254:growth & development / Q000378:metabolism / Q000601:surgery*; D013550:Swimming; D013997:Time Factors
D004041:Dietary Fats