Verbascoside isolated from Lepechinia speciosa has inhibitory activity against HSV-1 and HSV-2 in vitro.
Verbascoside has been isolated form L. speciosa after several different chromatographic methods. After its purification, the structure has been unequivocally established using modern spectroscopic techniques. As for the antiviral activity, the maximum non toxic concentration has been established and this concentration has been used in the anti herpes assay, in vitro. Mechanism of action for this molecule regarding the anti-herpes activity has been studied encompassing the following assays: virucidal activity, cellular receptor assay, penetration assay and intracellular assay, in order to understand the activity for this natural product.
Martins
Fernanda O
FO
Laboratório Experimental de Drogas Antivirais e Citotóxicas (LEDAC), Departamento de Virologia do Instituto de Microbiologia Prof Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), CCS, Bloco I, Rio de Janeiro, Brasil.
Esteves
Patricia F
PF
Mendes
Gabriella S
GS
Barbi
Nanci S
NS
Menezes
Fabio S
FS
Romanos
Maria T V
MT
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002462:Cell Membrane / Q000378:metabolism; D002522:Chlorocebus aethiops; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D019686:Lamiaceae / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D014709:Vero Cells; D059808:Polyphenols
D000998:Antiviral Agents; D005960:Glucosides; D010636:Phenols; D010936:Plant Extracts; C058956:acteoside; D059808:Polyphenols