title: Poor glycemic control is associated with abnormal changes in 24-hour ambulatory blood pressure in children and adolescents with type 1 diabetes mellitus.
abstract: BACKGROUND
  Twenty-four hour ambulatory blood pressure (ABPM) is emerging as a valuable tool to assess blood pressure (BP) changes in children with type 1 diabetes mellitus (DM1). Hypertension (HTN) is an important risk factor for, and may be an important indicator of diabetic nephropathy. Early accurate identification of HTN in DM1 may improve outcomes.
  
  
  OBJECTIVE
  To evaluate BP in adolescents with DM1 using 24-hour ABPM, and to identify risk factors associated with abnormal blood pressure.
  
  
  METHODS
  The ABPM of 105 children with DM1 was reviewed. Mean systolic BP (sBP) percentile was determined from the National High Blood Pressure Education Program (NHBPEP) tables. The patients with abnormal sBP were compared to those with normal sBP with respect to age, race, sex, body mass index (BMI) percentile, duration of DM1, average hemoglobin A1c (HbA1c) over the preceding year, and family history of hypertension.
  
  
  RESULTS
  Mean sBP was normal in 71%, whereas 23% had pre-hypertension, and 6% had stage 1 hypertension. Those who had abnormal sBP (pre-hypertension and stage 1 hypertension) had higher HbA1c (p = 0.023) and were more likely to be male (p = 0.03) than those with normal sBP.
  
  
  CONCLUSIONS
  Stage 1 hypertension is present in 6%, and pre-hypertension in 23% of adolescents with DM1. Poor diabetes control and male gender appear to be risk factors for abnormal sBP as measured by 24-hour ambulatory blood pressure monitoring.
authors.affiliation: Division of Pediatric Endocrinology, Schneider Children's Hospital, North Shore Long Island Jewish Health System, New Hyde Park, NY, USA. mac9261@nyp.org
authors.forename: Manjula
authors.initials: M
authors.lastname: Chatterjee
authors.forename: Phyllis W
authors.initials: PW
authors.lastname: Speiser
authors.forename: Margaret
authors.initials: M
authors.lastname: Pellizzarri
authors.forename: Dennis E
authors.initials: DE
authors.lastname: Carey
authors.forename: Pavel
authors.initials: P
authors.lastname: Fort
authors.forename: Paula M
authors.initials: PM
authors.lastname: Kreitzer
authors.forename: Graeme R
authors.initials: GR
authors.lastname: Frank
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000208:ethnology / Q000378:metabolism*; D005192:Family Health; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006630:Hispanic or Latino / Q000208:ethnology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000208:ethnology / Q000378:metabolism*; D008297:Male; D009518:New York / Q000453:epidemiology; D012189:Retrospective Studies; D044465:White People / Q000208:ethnology
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin