Antimicrobial activity of Inga fendleriana extracts and isolated flavonoids.
The EtOAc and n-BuOH extracts of Inga fendleriana inhibited Gram-positive, but not Gram-negative bacteria; a narrow spectrum of activity against Staphylococcus epidermidis was detected. The MIC values of the extracts ranged from 125 to 850 microg/mL. Quercetin 3-methylether, myricetin 3-O-rhamnoside and tricetin showed antibacterial activity against the same bacterial strains with MICs in the range from 31 to 250 microg/mL. In time-kill kinetic studies, the flavonoids showed bactericidal effects at the concentrations corresponding to four times the MICs.
Pistelli
Luisa
L
Dipartimento di Scienze Farmaceutiche, Università di Pisa, Italy. luipi@farm.unipi.it
Bertoli
Alessandra
A
Noccioli
Cecilia
C
Mendez
Jeanette
J
Musmanno
Rosa Anna
RA
Di Maggio
Tiziana
T
Coratza
Grazietta
G
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D003470:Culture Media; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013210:Staphylococcus / Q000187:drug effects
D000890:Anti-Infective Agents; D003470:Culture Media; D005419:Flavonoids; D010936:Plant Extracts