title: Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes.
abstract: FRET analysis has been used to examine the folded conformations and differing kinetic stabilities of two DNA G-quadruplexes (c-kit 1 and c-kit 2) derived from sequences found in the promoter of the c-kit proto-oncogene.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW.
authors.forename: Adrian
authors.initials: A
authors.lastname: Fegan
authors.forename: Pravin S
authors.initials: PS
authors.lastname: Shirude
authors.forename: Liming
authors.initials: L
authors.lastname: Ying
authors.forename: Shankar
authors.initials: S
authors.lastname: Balasubramanian
mesh_terms: D031541:Fluorescence Resonance Energy Transfer; D054856:G-Quadruplexes; D007700:Kinetics; D009691:Nucleic Acid Denaturation; D011401:Promoter Regions, Genetic; D019009:Proto-Oncogene Proteins c-kit / Q000737:chemistry* / Q000235:genetics; D013816:Thermodynamics
chemical_list: D019009:Proto-Oncogene Proteins c-kit