[Changes of thyroxin and monocyte human leukocyte antigen-DR expression in senior patients with sepsis].
OBJECTIVE
To investigate the changes of thyroxin and monocyte human leukocyte antigen-DR expression in senior patients with sepsis and explore their clinical significance.


METHODS
According to the 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions, 125 senior patients with sepsis free of thyroid conditions were divided into non-severe sepsis group (n=86) and severe sepsis group (n=39), with another 30 healthy subjects as the control. Thyroid function was assayed by chemoluminescence method in these patients and monocyte HLA-DR expression was determined by flow cytometry.


RESULTS
Compared with the control group and non-severe sepsis cases, the levels of free T3 (FT3), free T4 (FT4), T3, T4 and monocyte HLA-DR expression were significantly lower in severe sepsis cases (P<0.05), but the levels of thyroid stimulating hormone (TSH) were comparable between the 3 groups (P>0.05). The non-severe sepsis cases showed significantly lower levels of FT3, FT4, T3, T4, TSH and monocyte HLA-DR expression than the control group (P<0.05). In severe sepsis group, the levels of FT3, FT4, T3, T4 and monocyte HLA-DR expression showed significant differences between the fatal cases and surviving cases (P<0.05).


CONCLUSIONS
The levels of thyroxin and monocyte human leukocyte antigen-DR expression are obviously lower in senior patients with severe sepsis, and their detection may well indicate the severity of the condition and help make prognostic judgment.
Wu
Jun
J
Department of Gerontology, General Hospital of Guangzhou Command, Guangzhou 510010, China. gzlnkwujun@hotmail.com
Zhang
Yuan-yuan
YY
Feng
De-guang
DG
Xu
Cheng
C
Xiong
Ri-cheng
RC
Yu
Zhou
Z
Guo
Zhen-hui
ZH
Su
Lei
L
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006684:HLA-DR Antigens / Q000097:blood* / Q000276:immunology; D006801:Humans; D008297:Male; D009000:Monocytes / Q000378:metabolism*; D011014:Pneumonia / Q000150:complications; D018805:Sepsis / Q000097:blood* / Q000209:etiology / Q000276:immunology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood
D006684:HLA-DR Antigens; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine