Osteolytic lesions marker in multiple myeloma.
The degradation product of collagen type I carboxy terminal telopeptide (ICTP) represents a new biochemical parameter that reflects the changes in the resorption properties of skeletal system. Affection of the skeleton is one of the most important characteristics of multiple myeloma (MM). We estimated significance of ICTP as osteolysis predictor and overall survival in comparison with standard prognostic parameters β(2)-microglobulin and C-reactive protein (CRP), in patients with MM. With our results, we have shown significant difference in serum level of ICTP (P = 0.009) between patients with and without osteolysis on conventional radiography. It was proved that ICTP is the most significant predictor of osteolysis (P = 0.09), while CRP is the most significant risk factor for overall survival (P < 0.01). Being highly significant predictor of osteolysis, ICTP can be used for identification of patients with MM who had increased risk for developing osteolytic lesions.
Djunic
Irena
I
Institute of Hematology, Clinical Center of Serbia, str Koste Todorovica 2, Belgrade, Serbia. irenadju@eunet.rs
Elezovic
Ivo
I
Marinkovic
Milica
M
Suvajdzic-Vukovic
Nada
N
Tomin
Dragica
D
Jankovic
Gradimir
G
Bila
Jelena
J
Antic
Darko
D
Vidovic
Ana
A
Neskovic
Borka
B
Nikolic-Vukosavljevic
Dragica
D
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D024042:Collagen Type I / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000473:pathology*; D010014:Osteolysis / Q000097:blood* / Q000473:pathology*; D010455:Peptides / Q000097:blood*; D011379:Prognosis; D015996:Survival Rate; D001613:beta 2-Microglobulin / Q000097:blood
D014408:Biomarkers, Tumor; D024042:Collagen Type I; D010455:Peptides; D001613:beta 2-Microglobulin; C052929:collagen type I trimeric cross-linked peptide; D002097:C-Reactive Protein