Nitric oxide: pros and cons in tumor progression.
Nitric oxide (NO), synthesized by NO synthase, is a mediator involved in different processes varying from neurotransmission, to affecting the vasculature. The role of NO in tumor development is multifaceted and depends on a variety of conditions that exist with in the cell. This review will discuss the pros and cons of NO in tumor progression and provide an overview of their significant part in metabolism, angiogenesis and their role in the activation of macrophages as well as tumor-associated macrophages. The role of natural products in the regulation of NO will also be discussed.
Prabhu
Vinod
V
Department of Biotechnology, Karunya University, Coimbatore 641114, Tamil Nadu, India.
Guruvayoorappan
C
C
D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use; D018450:Disease Progression; D006801:Humans; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000139:chemically induced; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000235:genetics / Q000378:metabolism*; D008517:Phytotherapy
D000970:Antineoplastic Agents; D001688:Biological Products; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase