title: Therapy with FasL-gene-modified dendritic cells confers a protective microenvironment in murine pregnancy.
abstract: Analysis of the expression of FasL in the local decidua of pregnant mice and examination of the apoptosis of T cells in peripheral blood and local decidua indicated that adoptive transference of FasL-gene-modified dendritic cells may induce pregnancy immune tolerance by increasing FasL expression in the maternal-fetal interface and inducing the apoptosis of T cells in local decidua but not the peripheral blood.
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai Pudong New Area Gongli Hospital, Shanghai, People's Republic of China.
authors.forename: Miao
authors.initials: M
authors.lastname: Xiong
authors.forename: Jihong
authors.initials: J
authors.lastname: Lu
authors.forename: Aimin
authors.initials: A
authors.lastname: Zhao
authors.forename: Liang
authors.initials: L
authors.lastname: Xu
authors.forename: Shimin
authors.initials: S
authors.lastname: Bao
authors.forename: Qide
authors.initials: Q
authors.lastname: Lin
authors.forename: Binlie
authors.initials: B
authors.lastname: Yang
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D017209:Apoptosis; D003656:Decidua / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology / Q000502:physiology*; D053222:Fas Ligand Protein / Q000096:biosynthesis / Q000502:physiology*; D005260:Female; D051379:Mice; D011247:Pregnancy; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D053222:Fas Ligand Protein; C505658:Fasl protein, mouse