title: Serum biochemical response to inhalant anesthetics in New Zealand white rabbits.
abstract: Anesthetics can affect biochemical parameters, complicating the interpretation of laboratory results and perhaps leading to erroneous diagnoses. The present study was performed to characterize variations in selected rabbit biochemical parameters after inhalant anesthetics. Twenty New Zealand White rabbits were allocated to 2 treatment groups (n = 10 animals each), which received either halothane or isoflurane. Anesthesia was induced by using a face-mask, and rabbits were intubated for maintenance of anesthesia for 30 min. Blood samples were obtained before induction and at 1, 10, 30, 60, and 120 min and 24, 48, and 72 h after intubation. Serum cholesterol, triglycerides, albumin, total proteins, total bilirubin, sodium, potassium, chloride, calcium, and phosphorus concentrations were measured by using an autoanalyzer. Administration of halothane significantly increased serum triglyceride levels and decreased serum cholesterol, albumin, total protein, and potassium levels. Isoflurane administration increased serum triglyceride, phosphorus, and chloride concentrations and decreased serum calcium and potassium levels. Caution is required in interpreting data on serum biochemical parameters from rabbits anesthetized with halothane or isoflurane.
authors.affiliation: Animal Physiology, College of Veterinary Medicine, Universidad Complutense Madrid, Madrid, Spain. aggil@vet.ucm.es
authors.forename: Alfredo González
authors.initials: AG
authors.lastname: Gil
authors.forename: Gema
authors.initials: G
authors.lastname: Silván
authors.forename: Alberto
authors.initials: A
authors.lastname: Villa
authors.forename: Pilar
authors.initials: P
authors.lastname: Millán
authors.forename: Leticia
authors.initials: L
authors.lastname: Martínez-Fernández
authors.forename: Juan C
authors.initials: JC
authors.lastname: Illera
mesh_terms: D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary*; D006221:Halothane / Q000008:administration & dosage*; D007530:Isoflurane / Q000008:administration & dosage*; D011817:Rabbits / Q000097:blood* / Q000502:physiology; D011897:Random Allocation
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane; D006221:Halothane