title: Synthesis and in vitro cytotoxic activity of compounds with pro-apoptotic potential.
abstract: In our search for new anticancer therapies, some compounds synthesized in our lab were selected and their potential cytotoxic activity was evaluated in vitro against two cancer cells lines including a solid tumor (UACC-62, melanoma) and a human lymphoma (JURKAT). Compounds showing cytotoxic activity were subjected to an apoptosis assay. Two compounds showed promising results.
authors.affiliation: Laboratório de Química de Produtos Naturais, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz (FIOCRUZ), Av. Augusto de Lima 1715, Belo Horizonte, MG 30190-002, Brazil.
authors.forename: Gisell
authors.initials: G
authors.lastname: Apicela Soares
authors.forename: Renata
authors.initials: R
authors.lastname: Barbosa de Oliveira
authors.forename: Saulo
authors.initials: S
authors.lastname: Fernandes de Andrade
authors.forename: Ricardo José
authors.initials: RJ
authors.lastname: Alves
authors.forename: Carlos
authors.initials: C
authors.lastname: Leomar Zani
authors.forename: Elaine Maria
authors.initials: EM
authors.lastname: de Souza-Fagundes
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3 / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D053938:DNA Fragmentation / Q000187:drug effects; D004273:DNA, Neoplasm / Q000032:analysis; D004354:Drug Screening Assays, Antitumor; D004789:Enzyme Activation / Q000187:drug effects; D005434:Flow Cytometry; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D053148:Caspase 3