Diastereoselective and enantioselective Mukaiyama aldol reactions of alpha-ketoesters using hydrogen bond catalysis.
Hydrogen bond catalyzed Mukaiyama aldol reactions of alpha-ketoesters proceed in high diastereo- and enantioselectivities, giving products possessing two chiral centers, of which one is a tertiary alcohol.
Gondi
Vijaya Bhasker
VB
Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA.
Hagihara
Koji
K
Rawal
Viresh H
VH
D000080:Acetals / Q000737:chemistry; D002384:Catalysis; D005030:Ethylenes / Q000737:chemistry; D006860:Hydrogen Bonding; D007659:Ketones / Q000737:chemistry*; D019289:Pyruvic Acid / Q000737:chemistry; D013237:Stereoisomerism
D000080:Acetals; D005030:Ethylenes; D007659:Ketones; D019289:Pyruvic Acid; C008223:ketene