Association between polymorphism of glutathione S-transferase P1 and chronic obstructive pulmonary disease: a meta-analysis.
BACKGROUND
It was proposed that glutathione S-transferase P1 (GSTP1) gene involved in detoxification of electrophilic substances may be related with lung function. The present study aimed at investigating the correlation between GSTP1 105Val/Val genotype and chronic obstruct pulmonary disease (COPD) using a meta-analysis of existed studies.


METHODS
The Embase, Ovid, and PubMed databases were searched to identify eligible studies published before October 1, 2009. Data were extracted using standardized forms and the pooled odds ratios (ORs) with 95% confidence intervals (CI) were assessed by a model of fixed- or random effects.


RESULTS
The values of odds ratios(ORs) for COPD were 0.634 (95%CI 0.426-0.943, p = 0.025) in GSTP1 Ile/Ile, 0.625 (95%CI 0.418-0.935, p = 0.022) in GSTP1 Ile/Val, and 0.633 (95% CI 0.430-0.933, p = 0.021) in both, as compared to GSTP1 Val/Val, respectively. The individuals with GSTP1 105Ile/Ile, Ile/Val, and both have about 37% reduction in the odds of COPD, as compared to individuals with GSTP1 105Val/Val.


CONCLUSIONS
The GSTP1 105Val/Val genotype is suggested to be a genetic contributor to COPD susceptibility, which should be furthermore clarified by studies with large sample sizes and careful control for age, sex, ethnicity, and cigarette smoking.
Yan
Fugui
F
Department of Respiratory Medicine, First Affiliated Hospital, Wenzhou Medical College, Wenzhou, PR China.
Chen
Chengshui
C
Jing
Jiyong
J
Li
Wen
W
Shen
Huahao
H
Wang
Xiangdong
X
D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics* / Q000503:physiopathology; D012307:Risk Factors
C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi