Plasma water as a diagnostic tool in the assessment of dehydration in children with acute gastroenteritis.
Acute gastroenteritis is common in childhood. The estimation of the degree of dehydration is essential for management of acute gastroenteritis. Plasma water was assessed as a diagnostic tool in children with acute gastroenteritis and dehydration admitted to hospital. In a prospective cohort study, 101 patients presenting at the emergency department with dehydration were included. Clinical assessment, routine laboratory tests, and plasma water measurement were performed. Plasma water was measured as a percentage of water content using dry weight method. During admission, patients were rehydrated in 12 h. Weight gain at the end of the rehydration period and 2 weeks thereafter was used to determine the percentage of weight loss as a gold standard for the severity of dehydration. Clinical assessment of dehydration was not significantly associated with the percentage of weight loss. Blood urea nitrogen (r = 0.3, p = 0.03), base excess (r =-0.31, p = 0.03), and serum bicarbonate (r = 0.32, p = 0.02) were significantly correlated with the percentage of weight loss. Plasma water did not correlate with the percentage of weight loss. On the basis of the presented data, plasma water should not be used as a diagnostic tool in the assessment of dehydration in children with acute gastroenteritis.
Plaisier
Annemarie
A
Department of Pediatrics, Maasstad Hospital, P.O. Box 9100, 3075 EA, Rotterdam, The Netherlands.
Maingay-de Groof
Femke
F
Mast-Harwig
Roechama
R
Kalkman
Patricia M J
PM
Wulkan
Remi W
RW
Verwers
Renee
R
Neele
Marjolein
M
Hop
Wim C J
WC
Groeneweg
Michael
M
D000208:Acute Disease; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003681:Dehydration / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D005759:Gastroenteritis / Q000150:complications*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010949:Plasma / Q000737:chemistry*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D015431:Weight Loss