title: Discrete wavelet transform de-noising in eukaryotic gene splicing.
abstract: BACKGROUND
  This paper compares the most common digital signal processing methods of exon prediction in eukaryotes, and also proposes a technique for noise suppression in exon prediction. The specimen used here which has relevance in medical research, has been taken from the public genomic database - GenBank.
  
  
  METHODS
  Here exon prediction has been done using the digital signal processing methods viz. binary method, EIIP (electron-ion interaction psuedopotential) method and filter methods. Under filter method two filter designs, and two approaches using these two designs have been tried. The discrete wavelet transform has been used for de-noising of the exon plots.
  
  
  RESULTS
  Results of exon prediction based on the methods mentioned above, which give values closest to the ones found in the NCBI database are given here. The exon plot de-noised using discrete wavelet transform is also given.
  
  
  CONCLUSIONS
  Alterations to the proven methods as done by the authors, improves performance of exon prediction algorithms. Also it has been proven that the discrete wavelet transform is an effective tool for de-noising which can be used with exon prediction algorithms.
authors.affiliation: Department of Electronics and Instrumentation, College of Engineering, Kidangoor, Kottayam, Kerala, India. tinapgcusat@gmail.com
authors.forename: Tina P
authors.initials: TP
authors.lastname: George
authors.forename: Tessamma
authors.initials: T
authors.lastname: Thomas
mesh_terms: D000465:Algorithms; D030541:Databases, Genetic; D056890:Eukaryota / Q000235:genetics; D005091:Exons; D012326:RNA Splicing / Q000235:genetics*