title: Effect of probiotic supplementation in the first 6 months of life on specific antibody responses to infant Hepatitis B vaccination.
abstract: Probiotics have been shown to enhance specific immune responses to vaccines. We aim to assess the effect of probiotic supplementation on specific IgG antibody responses to Hepatitis B (HepB) vaccination in infants. Compared to controls, probiotic supplementation improved HepB surface antibody responses in subjects receiving monovalent doses of HepB vaccine at 0, 1 month and a DTPa-HepB combination vaccine at 6 months [placebo (n=28): 187.97 (180.70-195.24), probiotic (n=29): 345.70 (339.41-351.99)mIU/ml] (p=0.069), but not those who received 3 monovalent doses [placebo (n=68): 302.34 (296.31-308.37), probiotic (n=77): 302.06 (296.31-307.81)mIU/ml] (p=0.996). Probiotics may enhance specific antibody responses in infants receiving certain Hepatitis B vaccine schedules.
authors.affiliation: Department of Paediatrics, Yong Loo Lin School of Medicine, National University Health System, Singapore 119074, Singapore.
authors.forename: Shu E
authors.initials: SE
authors.lastname: Soh
authors.forename: Dave Qi Rong
authors.initials: DQ
authors.lastname: Ong
authors.forename: Irvin
authors.initials: I
authors.lastname: Gerez
authors.forename: Xiaoe
authors.initials: X
authors.lastname: Zhang
authors.forename: Pavithra
authors.initials: P
authors.lastname: Chollate
authors.forename: Lynette Pei-Chi
authors.initials: LP
authors.lastname: Shek
authors.forename: Bee Wah
authors.initials: BW
authors.lastname: Lee
authors.forename: Marion
authors.initials: M
authors.lastname: Aw
mesh_terms: D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology; D005260:Female; D018073:Haemophilus Vaccines / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000097:blood*; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010919:Placebos / Q000008:administration & dosage; D019936:Probiotics / Q000008:administration & dosage*
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D007074:Immunoglobulin G; D010919:Placebos; C122182:diphtheria-tetanus-acellular pertussis-Hib-hepatitis B vaccine