title: Furosemide impairs nasal mucociliary clearance in humans.
abstract: Furosemide, a potent diuretic, affects ion and water movement across the respiratory epithelium. However, the effects of furosemide, as clinically used, on mucociliary clearance, a critical respiratory defense mechanism, are still lacking in humans. Fourteen young healthy subjects were assigned to three random interventions, spaced one-week apart: no intervention (control), oral furosemide (40mg), and furosemide+oral volume replacement (F+R). Nasal mucociliary clearance was assessed by saccharine test (STT), and mucus properties were in vitro evaluated by means of contact angle and transportability by sneeze. Urine output and osmolality were also evaluated. Urine output increased and reduced urine osmolality in furosemide and F+R compared to the control condition. STT remained stable in the control group. In contrast, STT increased significantly (40%) after furosemide and F+R. There were no changes in vitro mucus properties in all groups. In conclusion, furosemide prolongs STT in healthy young subjects. This effect is not prevented by fluid replacement, suggesting a direct effect of furosemide on the respiratory epithelium.
authors.affiliation: Department of Physiotherapy, Communication Science and Disorders, Occupational Therapy, LIM 34, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Goto
authors.forename: Giuliana M
authors.initials: GM
authors.lastname: Torres
authors.forename: Antonio C
authors.initials: AC
authors.lastname: Seguro
authors.forename: Paulo H N
authors.initials: PH
authors.lastname: Saldiva
authors.forename: Geraldo
authors.initials: G
authors.lastname: Lorenzi-Filho
authors.forename: Naomi K
authors.initials: NK
authors.lastname: Nakagawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D004232:Diuretics / Q000009:adverse effects*; D005665:Furosemide / Q000009:adverse effects*; D006801:Humans; D009079:Mucociliary Clearance / Q000187:drug effects* / Q000502:physiology; D009297:Nasal Mucosa / Q000187:drug effects* / Q000503:physiopathology; D009668:Nose Diseases / Q000139:chemically induced* / Q000503:physiopathology*; D013997:Time Factors; D055815:Young Adult
chemical_list: D004232:Diuretics; D005665:Furosemide