title: Serum uric acid levels and neuromyelitis optica.
abstract: Uric acid (UA) has been reported to be reduced in the serum of patients with multiple sclerosis (MS) and optic neuritis (ON). However, the relationship between UA and neuromyelitis optica (NMO) was unknown. NMO was claimed to be a distinct nosologic entity from MS. The aim of our study was to investigate the correlation between serum UA level and the clinical characteristics of NMO. The serum UA level was measured in 403 Chinese patients; 69 with NMO, 32 ON, 127 MS, 80 cerebral infarction (CI) patients, and 95 healthy controls (CTL). Serum UA level in NMO was significantly lower than that in CI (249.89 +/- 93.74 vs. 315.42 +/- 85.57 micromol/L, p = 0.004) and CTL (249.89 +/- 93.74 vs. 314.33 +/- 102.05 micromol/L, p < 0.0001). However, no difference was found between NMO and MS (p = 0.496) or NMO and ON (p = 0.858). When the analysis was performed in the female cohort separately, UA level was significantly lower in females than in males in all groups. It was also shown in our study that UA level in patients with NMO was not correlated with disease activity revealed by MRI, disease disability or duration of disease. Our results indicated a reduced serum UA level in patients with NMO.
authors.affiliation: Department Of Neurology, The Third Affiliated Hospital, Sun Yat-Sen University, 510630 Guangzhou, Guangdong, China. pfh93@21cn.com
authors.forename: Fuhua
authors.initials: F
authors.lastname: Peng
authors.forename: Xiufeng
authors.initials: X
authors.lastname: Zhong
authors.forename: Xuhui
authors.initials: X
authors.lastname: Deng
authors.forename: Wei
authors.initials: W
authors.lastname: Qiu
authors.forename: Aimin
authors.initials: A
authors.lastname: Wu
authors.forename: Youming
authors.initials: Y
authors.lastname: Long
authors.forename: Xueqiang
authors.initials: X
authors.lastname: Hu
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Dai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D020520:Brain Infarction / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D015331:Cohort Studies; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood; D009471:Neuromyelitis Optica / Q000097:blood* / Q000473:pathology; D012720:Severity of Illness Index; D012737:Sex Factors; D013997:Time Factors; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D014527:Uric Acid