Is high consumption of antibiotics associated with Clostridium difficile polymerase chain reaction-ribotype 027 infections in France?
We compared antibiotic consumption between hospitals affected by a strain of Clostridium difficile designated as polymerase chain reaction-ribotype 027 (CD-027) and those unaffected during an outbreak in northern France. The mean consumption of several beta-lactams, amikacin, and fluoroquinolones was high in affected hospitals (P < .05). However, only levofloxacin and imipenem remained associated with emerging CD-027 in the multivariate analysis, suggesting that those antibiotics should be better targeted by prevention campaigns.
Birgand
Gabriel
G
Regional Coordinating Center for Nosocomial Infection Control, Paris, France.
Miliani
Katiuska
K
Carbonne
Anne
A
Astagneau
Pascal
P
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016360:Clostridioides difficile / Q000145:classification / Q000187:drug effects*; D003015:Clostridium Infections / Q000453:epidemiology*; D003428:Cross Infection; D004196:Disease Outbreaks; D005602:France / Q000453:epidemiology; D006761:Hospitals / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D016133:Polymerase Chain Reaction; D010818:Practice Patterns, Physicians'; D021521:Ribotyping
D000900:Anti-Bacterial Agents