title: Bayesian logic in statistical test control: application to coagulation factor VIII assay.
abstract: Coagulation factor VIII was assayed around the critical concentration of 80 U/dl, which is optimal for postoperative haemostasis in haemophiliac patients, in order to assess the use of Bayesian logic in interpreting internal quality control results during a change of reagent or control batch. A mathematical model based on Bayesian inference, requiring no preliminary control-plan phase, was compared with a classical approach, which necessarily involves performing a preliminary phase. Tsiamyrtzis and Hawkins' Bayesian model proved applicable to rapid statistical control of factor VIII assay, detecting shift at least as efficiently as classical approaches, which depend on running the kind of costly and controversial preliminary control phase recommended by Shewhart.
authors.affiliation: Haemostasis Laboratory, Edouard Herriot Hospital, Lyon, France. frederic.sobas@chu-lyon.fr
authors.forename: Frédéric
authors.initials: F
authors.lastname: Sobas
authors.forename: Audrey
authors.initials: A
authors.lastname: Bellisario
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Tsiamyrtzis
authors.forename: Anne
authors.initials: A
authors.lastname: Lienhart
authors.forename: Christophe
authors.initials: C
authors.lastname: Nougier
authors.forename: Claude
authors.initials: C
authors.lastname: Négrier
mesh_terms: D005169:Factor VIII / Q000032:analysis*; D006801:Humans; D015233:Models, Statistical; D011786:Quality Control
chemical_list: D005169:Factor VIII