Simultaneous EEG-fMRI in patients with Unverricht-Lundborg disease: event-related desynchronization/synchronization and hemodynamic response analysis.
We performed simultaneous acquisition of EEG-fMRI in seven patients with Unverricht-Lundborg disease (ULD) and in six healthy controls using self-paced finger extension as a motor task. The event-related desynchronization/synchronization (ERD/ERS) analysis showed a greater and more diffuse alpha desynchronization in central regions and a strongly reduced post-movement beta-ERS in patients compared with controls, suggesting a significant dysfunction of the mechanisms regulating active movement and movement end. The event-related hemodynamic response obtained from fMRI showed delayed BOLD peak latency in the contralateral primary motor area suggesting a less efficient activity of the neuronal populations driving fine movements, which are specifically impaired in ULD.
Visani
Elisa
E
Department of Neurophysiopathology, Carlo Besta IRCCS Neurological Institute, 20133 Milan, Italy. visani.e@istituto-besta.it
Minati
Ludovico
L
Canafoglia
Laura
L
Gilioli
Isabella
I
Salvatoni
Lucia
L
Varotto
Giulia
G
Fazio
Patrik
P
Aquino
Domenico
D
Bruzzone
Maria Grazia
MG
Franceschetti
Silvana
S
Panzica
Ferruccio
F
D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D005385:Fingers / Q000294:innervation; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D009068:Movement / Q000502:physiology; D010100:Oxygen / Q000097:blood; D011597:Psychomotor Performance / Q000502:physiology; D018709:Statistics, Nonparametric; D013997:Time Factors; D020194:Unverricht-Lundborg Syndrome / Q000473:pathology* / Q000503:physiopathology
D010100:Oxygen