Chitosan and alginate polyelectrolyte complex membranes and their properties for wound dressing application.
This study investigated the characteristics and drug release properties of membranes of chitosan and alginate prepared via a casting/solvent evaporation technique. Membranes of chitosan and alginate with silver sulfadiazine as model drug incorporated in different concentrations and different membrane compositions were obtained. The polyblend solution viscosity reached to the highest at the composition polyblends of (1:1). This chitosan/alginate membranes showed pH- and ionic strength-dependent water uptake properties and had the WVTR rang from 442 to 618 g/m(2)/day. The maximum value of the dry membrane of breaking strength was 52.16 MPa and the maximum value of the wet membrane breaking elongation was 46.28%. The results of controlled release studies showed that the silver sulfadiazine release rate was the fastest when the alginate content was 50%. On the basis of the requisite physical properties, the chitosan-alginate PEC membrane can be considered for potential wound dressing or controlled release application.
Meng
Xin
X
Institute of Medical Equipment, Academy of Military Medical Sciences, Tianjin, 300161, People's Republic of China.
Tian
Feng
F
Yang
Jian
J
He
Chun-Nian
CN
Xing
Nan
N
Li
Fan
F
D000464:Alginates; D001458:Bandages; D048271:Chitosan; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D008566:Membranes; D009994:Osmolar Concentration; D012837:Silver Sulfadiazine; D014783:Viscosity; D014867:Water
D000464:Alginates; D006603:Hexuronic Acids; D014867:Water; D020723:Glucuronic Acid; D048271:Chitosan; D012837:Silver Sulfadiazine