title: Omalizumab: when the non-responder is a late-responder.
abstract: Omalizumab is an anti-IgE monoclonal antibody available since 2006 for the treatment of GINA step 4 asthma. We studied a 41-year old male who has been suffering from severe steroid-resistant asthma with severe co-morbidity and treated with Omalizumab. He was found to be non-responder to the treatment until the 48th week, starting from which we began to see a distinct improvement in the symptoms and all the correlated parameters, in addition to remission of the co-existent allergy to milk.
  
  
  CONCLUSIONS
  we wish to point out the late response to Omalizumab, which occurred way beyond the times envisaged in literature. It seems possible that some patients are late responders to the drug.
authors.affiliation: Department of Respiratory Diseases, S. Maria Nuova Hospital - Reggio Emilia, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Menzella
authors.forename: N
authors.initials: N
authors.lastname: Facciolongo
authors.forename: C
authors.initials: C
authors.lastname: Castagnetti
authors.forename: A
authors.initials: A
authors.lastname: Simonazzi
authors.forename: L
authors.initials: L
authors.lastname: Zucchi
mesh_terms: D000328:Adult; D000420:Albuterol / Q000008:administration & dosage / Q000031:analogs & derivatives; D000485:Allergens / Q000276:immunology; D000730:Androstadienes / Q000008:administration & dosage; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D061067:Antibodies, Monoclonal, Humanized; D001249:Asthma / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage; D018572:Disease-Free Survival; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D000068298:Fluticasone; D005512:Food Hypersensitivity / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008892:Milk / Q000276:immunology; D000069444:Omalizumab; D000068299:Salmeterol Xinafoate; D013147:Spirometry; D013997:Time Factors
chemical_list: D000485:Allergens; D000730:Androstadienes; D018927:Anti-Asthmatic Agents; D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D001993:Bronchodilator Agents; D000069444:Omalizumab; D000068299:Salmeterol Xinafoate; D000068298:Fluticasone; D000420:Albuterol