title: [Expressions of E-cadherin and beta-catenin in LNCaP and ARCaP cell lines and their significance].
abstract: OBJECTIVE
  To observe the expressions of E-cadherin and beta-catenin in LNCaP and ARCaP cell lines and explore their relationship with the metastasis of human prostate cancer.
  
  
  METHODS
  The expressions and distribution of E-cadherin and beta-catenin in LNCaP and ARCaP cell lines (IF11 and IA8) were detected by Western blot and immunofluorescent staining.
  
  
  RESULTS
  The expression of E-cadherin was high in LNCaP, but absent in IF11 and IA8, while beta-catenin was expressed highly in IF11 and LA8, but lowly in LNCaP. Immunofluorescent staining showed that E-cadherin was mainly in the membrane of LNCaP, while beta-catenin both in the membrane of LNCaP and in the nuclei of IF11 and IA8.
  
  
  CONCLUSIONS
  E-cadherin and beta-catenin are differently expressed and distributed in prostate cancer cell lines with different characteristics of epithelial-mesenchymal transition (EMT), and the abnormal activation of the beta-catenin signal pathway may be involved in the EMT of prostate cancer cells.
authors.affiliation: Department of Urology, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beiing 100029, China. yongguangjiang2008@yahoo.com.cn
authors.forename: Yong-guang
authors.initials: YG
authors.lastname: Jiang
authors.forename: Jia-hui
authors.initials: JH
authors.lastname: Zhao
authors.forename: Yong
authors.initials: Y
authors.lastname: Luo
authors.forename: Da-lin
authors.initials: DL
authors.lastname: He
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Xin-hao
authors.initials: XH
authors.lastname: Cui
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
mesh_terms: D015820:Cadherins / Q000378:metabolism*; D045744:Cell Line, Tumor; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D015820:Cadherins; D051176:beta Catenin