title: C1qTNF-related protein-6 mediates fatty acid oxidation via the activation of the AMP-activated protein kinase.
abstract: C1qTNF-related proteins (CTRPs) are involved in diverse processes including metabolism, inflammation host defense, apoptosis, cell differentiation, autoimmunity, hibernation, and organogenesis. However, the physiological role of CTRP6 remains poorly understood. Here we demonstrate that the globular domain of CTRP6 mediates the phosphorylation and activation of the 5'-AMP-activated protein kinase (AMPK) in skeletal muscle cells. In parallel with the activation of AMPK, CTRP6 induces the phosphorylation of acetyl coenzyme A carboxylase (ACC) and fatty acid oxidation in myocytes. Thus, CTRP6 plays a role in fatty acid metabolism via the AMPK-ACC pathway.
authors.affiliation: Department of Biochemistry, School of Medicine, Dongguk University, Kyungju 780-714, Republic of Korea.
authors.forename: Wan
authors.initials: W
authors.lastname: Lee
authors.forename: Mi-Jin
authors.initials: MJ
authors.lastname: Kim
authors.forename: Eun-Ju
authors.initials: EJ
authors.lastname: Park
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Choi
authors.forename: Seung-Yoon
authors.initials: SY
authors.lastname: Park
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D054392:Adipokines / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics / Q000502:physiology; D051379:Mice; D032342:Muscle Cells / Q000378:metabolism; D010084:Oxidation-Reduction; D010766:Phosphorylation; D017434:Protein Structure, Tertiary / Q000235:genetics / Q000502:physiology; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
chemical_list: D054392:Adipokines; C000606745:CTRP6 protein, mouse; D005227:Fatty Acids; D011506:Proteins; D055372:AMP-Activated Protein Kinases; D000103:Acetyl-CoA Carboxylase