title: Epidemiology of Cryptococcus gattii, British Columbia, Canada, 1999-2007.
abstract: British Columbia, Canada, has the largest reported population of Cryptococcus gattii-infected persons worldwide. To assess the impact of illness, we retrospectively analyzed demographic and clinical features of reported cases, hospitalizations, and deaths during 1999-2007. A total of 218 cases were reported (average annual incidence 5.8 per million persons). Most persons who sought treatment had respiratory illness (76.6%) or lung cryptococcoma (75.4%). Persons without HIV/AIDS hospitalized with cryptococcosis were more likely than those with HIV/AIDS to be older and admitted for pulmonary cryptococcosis. The 19 (8.7%) persons who died were more likely to be older and to have central nervous system disease and infection from the VGIIb strain. Although incidence in British Columbia is high, the predominant strain (VGIIa) does not seem to cause greater illness or death than do other strains. Further studies are needed to explain host and strain characteristics for regional differences in populations affected and disease outcomes.
authors.affiliation: British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada. eleni.galanis@bccdc.ca
authors.forename: Eleni
authors.initials: E
authors.lastname: Galanis
authors.forename: Laura
authors.initials: L
authors.lastname: Macdougall
authors.forename: Sarah
authors.initials: S
authors.lastname: Kidd
authors.forename: Mohammad
authors.initials: M
authors.lastname: Morshed
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000401:mortality; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001955:British Columbia / Q000453:epidemiology; D002648:Child; D003453:Cryptococcosis / Q000453:epidemiology* / Q000401:mortality; D056285:Cryptococcus gattii; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D008172:Lung Diseases, Fungal / Q000453:epidemiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult