The effect of electroacupuncture on T cell responses in rats with experimental autoimmune encephalitis.
Successive electroacupuncture (EA) stimulation on Zusanli ST36 acupoints of rats with experimental autoimmune encephalitis (EAE), which is an inflammatory disease mediated by autoreactive T cells, relieved disease severity, inhibited specific T cell proliferation and rebuilt the CD4+ T cell subset balance. In addition, EA-treated rats had significantly higher ACTH concentrations in vivo compared to untreated EAE rats. These results indicated that EA stimulation could relieve the severity of EAE by restoring balance to the Th1/Th2/Th17/Treg Th cell subset responses by stimulating the hypothalamus to increase ACTH secretion.
Liu
Yu-mei
YM
Department of Neurobiology, Harbin Medical University, Heilongjiang Provincial Key Laboratory of Neurobiology, 157 Bao Jian Road, Harbin 150081, China.
Liu
Xi-jun
XJ
Bai
Sha-Sha
SS
Mu
Li-li
LL
Kong
Qing-fei
QF
Sun
Bo
B
Wang
Dan-dan
DD
Wang
Jing-hua
JH
Shu
Shi
S
Wang
Guang-you
GY
Li
Hu-lun
HL
D015669:Acupuncture Points; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism; D000818:Animals; D002452:Cell Count; D049109:Cell Proliferation; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D004195:Disease Models, Animal; D015671:Electroacupuncture / Q000379:methods*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D007031:Hypothalamus / Q000378:metabolism; D007108:Immune Tolerance / Q000502:physiology*; D007165:Immunosuppression Therapy / Q000379:methods*; D008213:Lymphocyte Activation / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism; D016896:Treatment Outcome
D000324:Adrenocorticotropic Hormone