title: Antibacterial constituents from the roots of Erythrina herbacea against methicillin-resistant Staphylococcus aureus.
abstract: Two new compounds, erybacin A (1) and erybacin B (2), together with 10 known compounds (3- 12), were isolated from the roots of Erythrina herbacea. Their structures were established on the basis of spectroscopic analyses. Erybacin A is a rare, naturally occurring 1-hydroxy-1,3-diphenylpropan-2-one derivative. The isolated compounds were evaluated for their antibacterial activity against 13 strains of methicillin-resistant Staphylococcus aureus (MRSA). The new compound 2 showed a potent bactericidal activity against MRSA.
authors.affiliation: Faculty of Pharmacy, Meijo University, Yagoto, Tempaku-ku, Nagoya, Japan. hitoshi@ccmfs.meijo-u.ac.jp
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Masaru
authors.initials: M
authors.lastname: Sudo
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kawamura
authors.forename: Masaru
authors.initials: M
authors.lastname: Sato
authors.forename: Ryozo
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: Toshio
authors.initials: T
authors.lastname: Fukai
authors.forename: Eiji
authors.initials: E
authors.lastname: Sakai
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Tanaka
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004895:Erythrina / Q000737:chemistry*; D016106:Methicillin Resistance / Q000187:drug effects*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D010936:Plant Extracts; D012118:Resorcinols; C554607:erybacin A; C554608:erybacin B