Synthesis and anti-influenza virus activity of dihydrofuran-fused perhydrophenanthrenes with a benzyloxy-type side-chain.
As one of our ongoing research project concerning development of a novel anti-influenza virus agent, dihydrofuran-fused perhydrophenanthrenes were derivatized by means of Williamson ether synthesis and Suzuki-Miyaura cross coupling reactions. Newly synthesized compounds were subjected to evaluation of anti-influenza virus activity using influenza A/Aichi/2/68 (H3N2 subtype) virus strain by a plaque titration method. These investigations revealed that incorporation of benzyl-type ether substituents was effective for exerting the inhibition activity of influenza virus proliferation.
Matsuya
Yuji
Y
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan. matsuya@pha.u-toyama.ac.jp
Suzuki
Nozomi
N
Kobayashi
Shin-Ya
SY
Miyahara
Tatsuro
T
Ochiai
Hiroshi
H
Nemoto
Hideo
H
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D004285:Dogs; D005663:Furans / Q000737:chemistry*; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects* / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared
D000998:Antiviral Agents; D005663:Furans; D010616:Phenanthrenes