title: Selenium supplementation and premature (pre-labour) rupture of membranes: a randomised double-blind placebo-controlled trial.
abstract: The aim was to determine if selenium supplementation during pregnancy reduces the occurrence of premature (pre-labour) rupture of membranes (PROM). A total of 166 primigravid pregnant women in the first trimester of pregnancy, were randomised to receive 100 microg of selenium (n = 83, drop-outs = 22) or a placebo (n = 83, drop-outs = 19) per day until delivery. The incidence of PROM, as well as serum selenium concentrations were evaluated at baseline and at the end of the study. Supplementation with selenium was associated with a significant increase in mean serum selenium concentration at term (p < 0.001). In contrast, mean serum selenium concentration remained unchanged in the control group (p > 0.05). The incidence of PROM was significantly lower in the selenium group (n = 8, 13.1%) than in the control group (n = 22, 34.4%) (p < 0.01). Our findings indicate that selenium supplementation (100 microg/day) in pregnant women effectively reduces the incidence of PROM.
authors.affiliation: Department of Obstetrics and Gynaecology, OM-Albanin Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
authors.forename: F
authors.initials: F
authors.lastname: Tara
authors.forename: M P
authors.initials: MP
authors.lastname: Rayman
authors.forename: H
authors.initials: H
authors.lastname: Boskabadi
authors.forename: M
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.forename: A
authors.initials: A
authors.lastname: Sahebkar
authors.forename: O
authors.initials: O
authors.lastname: Yazarlu
authors.forename: S
authors.initials: S
authors.lastname: Ouladan
authors.forename: S
authors.initials: S
authors.lastname: Tavallaie
authors.forename: M
authors.initials: M
authors.lastname: Azimi-Nezhad
authors.forename: M T
authors.initials: MT
authors.lastname: Shakeri
authors.forename: M S
authors.initials: MS
authors.lastname: Teymoori
authors.forename: B S
authors.initials: BS
authors.lastname: Razavi
authors.forename: M
authors.initials: M
authors.lastname: Oladi
authors.forename: G
authors.initials: G
authors.lastname: Ferns
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000517:prevention & control*; D006801:Humans; D011247:Pregnancy; D012643:Selenium / Q000097:blood / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D012643:Selenium