title: Congenital pigment synthesizing melanoma of the scalp.
abstract: The pigment synthesizing melanoma, so-called animal type melanoma, is a rare variant of melanoma that is characterized by prominent melanin production and an unpredictable prognosis. Congenital onset of this melanoma is exceedingly rare. A 2-month-old Korean girl had a black nodule and a satellite black macule on the scalp which were noticed at birth. She received a surgical resection 3 months later because of rapidly growing lesions and the histopathologic features of a pigment synthesizing melanoma. Two months later, she returned with cervical area swelling, and the excised multiple lymph nodes showed metastatic malignant melanoma. The exact origin and pathogenesis of congenital pigment synthesizing melanoma is different from the more common forms of melanoma and remains poorly understood.
authors.affiliation: Department of Dermatology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School and Center for Biomedical Human Resources, Gwangju, Korea.
authors.forename: Sook Jung
authors.initials: SJ
authors.lastname: Yun
authors.forename: Dong Kyun
authors.initials: DK
authors.lastname: Han
authors.forename: Min-Cheol
authors.initials: MC
authors.lastname: Lee
authors.forename: Jee-Bum
authors.initials: JB
authors.lastname: Lee
authors.forename: Hee Jo
authors.initials: HJ
authors.lastname: Baek
authors.forename: Si Young
authors.initials: SY
authors.lastname: Bae
authors.forename: Tai Ju
authors.initials: TJ
authors.lastname: Hwang
authors.forename: Sam Yong
authors.initials: SY
authors.lastname: Lee
authors.forename: Joon Kyoo
authors.initials: JK
authors.lastname: Lee
authors.forename: Hoon
authors.initials: H
authors.lastname: Kook
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007223:Infant; D016898:Interferon-alpha / Q000008:administration & dosage; D007376:Interleukin-2 / Q000008:administration & dosage; D008207:Lymphatic Metastasis / Q000473:pathology; D008543:Melanins / Q000096:biosynthesis; D008545:Melanoma / Q000151:congenital* / Q000473:pathology / Q000601:surgery; D012878:Skin Neoplasms / Q000151:congenital* / Q000601:surgery; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D016898:Interferon-alpha; D007376:Interleukin-2; D008543:Melanins; D014747:Vinblastine; D003606:Dacarbazine; D002945:Cisplatin