Gypenoside LXXIV ameliorates scopolamine-induced learning deficit in mice.
Gypenoside LXXIV (G-74), a major constituent of GYNOSTEMMA PENTAPHYLLUM Makino (GP; family Cucurbitaceae), was isolated and its memory-enhancing effects were investigated in scopolamine-treated mice in passive-avoidance and Morris water maze tests. G-74 potently reversed memory impairment caused by scopolamine. G-74 also significantly shortened the scopolamine-prolonged escape latencies in the Morris water maze test (p < 0.05) and increased the scopolamine-shortened swimming time within the platform quadrant (p < 0.05). Based on these findings, G-74 might improve learning deficits.
Joh
Eun-Ha
EH
Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, Dongdaemun-Ku, Seoul, Korea.
Yang
Jeong-Wha
JW
Kim
Dong-Hyun
DH
D000818:Animals; D029774:Gynostemma; D007859:Learning Disabilities / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D018782:Maze Learning; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000494:pharmacology; D012601:Scopolamine / Q000633:toxicity*
D010936:Plant Extracts; C474918:gypenoside; D012601:Scopolamine