Polar spongioblastoma: A high-grade glioma that does not contain the IDH1 mutation or 1p/19q LOH.
We report a case of an unusual glioma termed "primitive polar spongioblastoma" that displayed characteristic palisading tumor cells at the light microscopic level. The patient was a 52-year-old woman who underwent subtotal removal for a left frontotemporal tumor. The palisading pattern was present throughout the tumor. Several glial markers were revealed by immunohistochemical examination, but no neuronal markers were observed. Genetic studies showed O-6-methylguanine-DNA methyltransferase (MGMT) methylation, wild type IDH1, and the absence of 1p/19q loss of heterozygosity (LOH) in the tumor genes. Based on histological and genetic features, this tumor might not be suited to any of neuroepithelial tumor in the recent WHO classification. We consider that cases such as this should be temporarily set under a separate heading and be entrusted to future investigation after more cases have been accumulated.
Nagaishi
Masaya
M
Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma,Department of Neurosurgery, Koshigaya hospital Dokkyo University School of Medicine, Saitama andDepartment of Neurosurgery, Dokkyo University School of Medicine, Tochigi, Japan.
Tanaka
Yoshihiro
Y
Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma,Department of Neurosurgery, Koshigaya hospital Dokkyo University School of Medicine, Saitama andDepartment of Neurosurgery, Dokkyo University School of Medicine, Tochigi, Japan.
Iwatate
Kensho
K
Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma,Department of Neurosurgery, Koshigaya hospital Dokkyo University School of Medicine, Saitama andDepartment of Neurosurgery, Dokkyo University School of Medicine, Tochigi, Japan.
Yokoo
Hideaki
H
Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma,Department of Neurosurgery, Koshigaya hospital Dokkyo University School of Medicine, Saitama andDepartment of Neurosurgery, Dokkyo University School of Medicine, Tochigi, Japan.
Ueki
Keisuke
K
Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma,Department of Neurosurgery, Koshigaya hospital Dokkyo University School of Medicine, Saitama andDepartment of Neurosurgery, Dokkyo University School of Medicine, Tochigi, Japan.
Hyodo
Akio
A
Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma,Department of Neurosurgery, Koshigaya hospital Dokkyo University School of Medicine, Saitama andDepartment of Neurosurgery, Dokkyo University School of Medicine, Tochigi, Japan.
Nakazato
Yoichi
Y
Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma,Department of Neurosurgery, Koshigaya hospital Dokkyo University School of Medicine, Saitama andDepartment of Neurosurgery, Dokkyo University School of Medicine, Tochigi, Japan.
D000293:Adolescent; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002648:Child; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D019175:DNA Methylation; D015254:DNA Modification Methylases; D045643:DNA Repair Enzymes; D005260:Female; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007223:Infant; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D019656:Loss of Heterozygosity; D008297:Male; D008875:Middle Aged; D018302:Neoplasms, Neuroepithelial / Q000235:genetics* / Q000473:pathology; D025521:Tumor Suppressor Proteins
D025521:Tumor Suppressor Proteins; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes