[Expression of DC-SIGNR in the primary trophoblast cells and its significance].
OBJECTIVE
To study the expression of DC-SIGNR in human placenta and trophoblast cells cultured in vitro, and provided a basis for experiment in vitro aiming to investigate the mechanism of receptor-mediated intrauterine transmission.


METHODS
Primary culture system of human chorionic trophoblast cells were established. The expression of DC-SIGN and DC-SIGNR was determined by Immunohistochemistry (IHC) stain.


RESULTS
DC-SIGNR was mainly expressed in the membrane and plasm in placental trophoblast cells, Hofbauer cells and placental vascular endothelial cells.


CONCLUSIONS
The expression of DC-SIGNR in human placenta and trophoblast cells cultured in vitro is determined by IHC; The study provides a cellular basis for experiment in vitro aiming to investigate the mechanism of receptor-mediated intrauterine transmission.
Zhang
Qin
Q
Department of Obesterics and Gynecology, South-west Hospital, Third Military Medical University, Chongqin, China. zhangqin2003212@tom.com
Li
Jun-nan
JN
Linag
Zhi-qing
ZQ
D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D005260:Female; D015870:Gene Expression; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics* / Q000378:metabolism; D010920:Placenta / Q000166:cytology* / Q000378:metabolism; D011247:Pregnancy; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D014327:Trophoblasts / Q000378:metabolism*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C433029:CLEC4M protein, human