title: Brain plasticity following early life brain injury: insights from neuroimaging.
abstract: The developing human brain possesses a superior capacity to reorganize after focal lesions. This review describes mechanisms of reorganization following pre- and perinatally-acquired, unilateral brain lesions for motor, somatosensory, and language functions. In the motor system, unilateral damage to the corticospinal tract can lead to the maintenance of normally-transient ipsilateral corticospinal projections from the contralesional hemisphere. In some patients, this type of corticospinal (re)organization can achieve an active grasp function of the paretic hand, while in others no useful hand function develops although such projections exist. In the somatosensory system, periventricular lesions can be compensated by outgrowing thalamocortical projections forming "bypasses" around the defective white matter to reach the postcentral gyrus. By contrast, lesions in the postcentral gyrus often lead to marked somatosensory deficits. Finally, language functions can be taken over by the right hemisphere in cases of left hemispheric damage, often with excellent functional outcome. Knowledge of these mechanisms is necessary for establishing a "prognostic corridor" of development derived from neuroimaging in newborns with brain lesions.
authors.affiliation: Department of Pediatric Neurology and Developmental Medicine, University Children's Hospital, Tübingen, Germany. mstaudt@schoen-kliniken.de
authors.forename: Martin
authors.initials: M
authors.lastname: Staudt
mesh_terms: D001930:Brain Injuries / Q000503:physiopathology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009043:Motor Activity / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*