Bone diseases: Interferon regulatory factor-8 suppresses osteoclastogenesis.
To date, understanding of the molecular mechanisms of bone metabolism has centered on three tumor necrosis factor family members--RANK, its ligand RANKL and its decoy receptor osteoprotegrin. This view should now be modified, however, to incorporate the role of interferon regulatory factor-8.
Wagner
Hermann
H
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Trogestrasse 30, Munich, Germany. hermann.wagner@mikrobio.med.tum.de
D000818:Animals; D050835:Interferon Regulatory Factors / Q000378:metabolism*; D010010:Osteoclasts / Q000502:physiology*; D010024:Osteoporosis / Q000378:metabolism*; D053244:Osteoprotegerin / Q000378:metabolism; D053245:RANK Ligand / Q000378:metabolism; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000378:metabolism; D000099185:Interferon Regulatory Factor-8
D050835:Interferon Regulatory Factors; D053244:Osteoprotegerin; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; D000099185:Interferon Regulatory Factor-8