[The level of TNF-alpha secretion of PBMC in patients with chronic hepatitis C and nonalcoholic fatty liver].
OBJECTIVE
To study the roles of TNF-alpha secretion of PBMC in patients with chronic hepatitis C and Nonalcoholic fatty liver.


METHODS
The level of TNF-alpha secretion of PBMC in patients with chronic hepatitis C and Nonalcoholic fatty liver was detected by ELISA after culturing for 72 hours in vitro, as well as patients with chronic hepatitis C and the normal control.


RESULTS
(1) Compared with the normal control, the level of TNF-alpha in group with chronic hepatitis C and in group with chronic hepatitis C and Nonalcoholic fatty liver notably increased. (2) Compared with the group with chronic hepatitis C, the level of TNF-alpha in group with chronic hepatitis C and Nonalcoholic fatty liver also notably increased.


CONCLUSIONS
It suggested TNF-alpha takes important roles in the infection course of chronic hepatitis C with Nonalcoholic fatty liver.
Dong
Yi
Y
Department of Immunology, Institute of Infectious Diseases, the No. 302 Hospital of the People's Liberation Army, Beijing 100039, China.
Zhang
Hong-fei
HF
Zhu
Shi-shu
SS
Chen
Hao
H
Li
Jing
J
Cheng
Yun
Y
D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D002648:Child; D005234:Fatty Liver / Q000378:metabolism*; D005260:Female; D019698:Hepatitis C, Chronic / Q000378:metabolism*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D055815:Young Adult
D014409:Tumor Necrosis Factor-alpha