C1qTNF-related protein-6 mediates fatty acid oxidation via the activation of the AMP-activated protein kinase.
C1qTNF-related proteins (CTRPs) are involved in diverse processes including metabolism, inflammation host defense, apoptosis, cell differentiation, autoimmunity, hibernation, and organogenesis. However, the physiological role of CTRP6 remains poorly understood. Here we demonstrate that the globular domain of CTRP6 mediates the phosphorylation and activation of the 5'-AMP-activated protein kinase (AMPK) in skeletal muscle cells. In parallel with the activation of AMPK, CTRP6 induces the phosphorylation of acetyl coenzyme A carboxylase (ACC) and fatty acid oxidation in myocytes. Thus, CTRP6 plays a role in fatty acid metabolism via the AMPK-ACC pathway.
Lee
Wan
W
Department of Biochemistry, School of Medicine, Dongguk University, Kyungju 780-714, Republic of Korea.
Kim
Mi-Jin
MJ
Park
Eun-Ju
EJ
Choi
Young-Jin
YJ
Park
Seung-Yoon
SY
D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D054392:Adipokines / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics / Q000502:physiology; D051379:Mice; D032342:Muscle Cells / Q000378:metabolism; D010084:Oxidation-Reduction; D010766:Phosphorylation; D017434:Protein Structure, Tertiary / Q000235:genetics / Q000502:physiology; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
D054392:Adipokines; C000606745:CTRP6 protein, mouse; D005227:Fatty Acids; D011506:Proteins; D055372:AMP-Activated Protein Kinases; D000103:Acetyl-CoA Carboxylase