Transient decrease in cerebral motor pathway fractional anisotropy after focal ischemic stroke in monkey.
In this study, diffusion tensor MRI was used to examine the restoration of the cerebral white matter of macaque monkeys after unilateral cerebral multiple microinfarctions. Post-stroke, the monkeys showed deficits in several neurological functions, including motor functions, but most of the deficits resolved within 6 weeks. Very interestingly, the fractional anisotropy (a value determined by diffusion tensor MRI), of the monkeys' affected motor pathways dropped transiently, indicating a damage in the neural tracts. However, it returned to normal levels within 6 weeks after the stroke, concomitant with the gradual recovery of motor functions at subacute phase.
Chin
Yo
Y
Department of Integrated Biosciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan.
Sato
Yuki
Y
Mase
Mitsuhito
M
Kato
Tomomasa
T
Herculano
Bruno
B
Sekino
Masaki
M
Ohsaki
Hiroyuki
H
Ageyama
Naohide
N
Ono
Fumiko
F
Terao
Keiji
K
Yoshikawa
Yasuhiro
Y
Hisatsune
Tatsuhiro
T
D000818:Animals; D020520:Brain Infarction / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology*; D038524:Diffusion Magnetic Resonance Imaging; D004525:Efferent Pathways; D002546:Ischemic Attack, Transient / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D008252:Macaca fascicularis; D008297:Male; D020521:Stroke / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*