title: Effects of postoperative radiotherapy for temporomandibular joint ankylosis after gap arthroplasty: an animal study using sheep.
abstract: OBJECTIVE
  The aim of the present study was to examine the effects of postoperative irradiation on reducing heterotopic bone formation after gap arthroplasty release of temporomandibular joint ankylosis.
  
  
  METHODS
  Five sheep underwent induction of right temporomandibular joint ankylosis. After 3 months, the ankylosis was released by gap arthroplasty. At 24 hours after the release, they received a single radiation dose of 10 Gy. All sheep were sacrificed at 3 months after gap arthroplasty release. The body weight, jaw opening amount, and radiographs were measured at key intervals, with histologic assessment after death. The findings were compared with those in a control group treated with gap arthroplasty without irradiation.
  
  
  RESULTS
  The clinical measurements, radiographs, and histologic findings all revealed less evidence of reankylosis in the irradiated sheep.
  
  
  CONCLUSIONS
  The results of the present study have shown that a single radiation dose at 24 hours after gap arthroplasty for temporomandibular joint ankylosis inhibits heterotopic ossification.
authors.affiliation: First Department of Oral and Maxillofacial Surgery, Aichi Gakuin University School of Dentistry, Nagoya, Aichi, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Takaishi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kurita
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hatano
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Matsuura
authors.forename: Martin
authors.initials: M
authors.lastname: Borg
authors.forename: N Alastair
authors.initials: NA
authors.lastname: Goss
mesh_terms: D000818:Animals; D000844:Ankylosis / Q000532:radiotherapy / Q000601:surgery*; D001178:Arthroplasty / Q000379:methods*; D009999:Ossification, Heterotopic / Q000517:prevention & control*; D011182:Postoperative Care; D018714:Radiotherapy, Adjuvant; D012756:Sheep; D013705:Temporomandibular Joint Disorders / Q000532:radiotherapy* / Q000601:surgery*