title: Non-surgical chemotherapeutic treatment strategies for the management of periodontal diseases.
abstract: Periodontal diseases are initiated by subgingival periodontal pathogens in susceptible periodontal sites. The host immune response toward periodontal pathogens helps to sustain periodontal disease and eventual alveolar bone loss. Numerous adjunctive therapeutic strategies have evolved to manage periodontal diseases. Systemic and local antibiotics, antiseptics, and past and future host immune modulatory agents are reviewed and discussed to facilitate the dental practitioner's appreciation of this ever-growing field in clinical periodontics.
authors.affiliation: Department of Stomatology, College of Dental Medicine, Medical University of South Carolina, 30 Bee Steet - room 115, Charleston, SC 29425, USA.
authors.forename: Joe W
authors.initials: JW
authors.lastname: Krayer
authors.forename: Renata S
authors.initials: RS
authors.lastname: Leite
authors.forename: Keith L
authors.initials: KL
authors.lastname: Kirkwood
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000571:American Dental Association; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use; D002710:Chlorhexidine / Q000627:therapeutic use; D055113:Chronic Periodontitis / Q000188:drug therapy*; D003773:Dental Plaque / Q000188:drug therapy*; D017277:Drug Approval; D004338:Drug Combinations; D005891:Gingivitis / Q000188:drug therapy*; D006801:Humans; D056747:Immunomodulation / Q000187:drug effects; D061965:Matrix Metalloproteinase Inhibitors; D009067:Mouthwashes / Q000627:therapeutic use; D011448:Prostaglandin Antagonists / Q000627:therapeutic use; D012459:Salicylates / Q000627:therapeutic use; D013729:Terpenes / Q000627:therapeutic use; D014481:United States
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D061965:Matrix Metalloproteinase Inhibitors; D009067:Mouthwashes; D011448:Prostaglandin Antagonists; D012459:Salicylates; D013729:Terpenes; C057473:Listerine; D002710:Chlorhexidine