title: Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs.
abstract: The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs for further therapeutic development against the hepatitis B virus (HBV).
authors.affiliation: Spring Bank Pharmaceuticals Inc., Milford, MA, United States.
authors.forename: John E
authors.initials: JE
authors.lastname: Coughlin
authors.forename: Seetharamaiyer
authors.initials: S
authors.lastname: Padmanabhan
authors.forename: Guangrong
authors.initials: G
authors.lastname: Zhang
authors.forename: Cassandra J
authors.initials: CJ
authors.lastname: Kirk
authors.forename: Chandrika P
authors.initials: CP
authors.lastname: Govardhan
authors.forename: Brent E
authors.initials: BE
authors.lastname: Korba
authors.forename: Kathleen
authors.initials: K
authors.lastname: O'Loughlin
authors.forename: Carol E
authors.initials: CE
authors.lastname: Green
authors.forename: Jon
authors.initials: J
authors.lastname: Mirsalis
authors.forename: John D
authors.initials: JD
authors.lastname: Morrey
authors.forename: Radhakrishnan P
authors.initials: RP
authors.lastname: Iyer
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D002460:Cell Line; D005260:Female; D006509:Hepatitis B / Q000188:drug therapy*; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation; D009711:Nucleotides / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000998:Antiviral Agents; D009711:Nucleotides; D011355:Prodrugs