Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium.
A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown. We determined ABO genotypes (OO, AO, AA, AB, BO, and BB) in 1,534 cases and 1,583 controls from 12 prospective cohorts in PanScan, grouping participants by genotype-derived serologic blood type (O, A, AB, and B). Adjusted odds ratios (ORs) for pancreatic cancer by ABO alleles were calculated using logistic regression. Compared with blood type O, the ORs for pancreatic cancer in subjects with types A, AB, and B were 1.38 [95% confidence interval (95% CI), 1.18-1.62], 1.47 (95% CI, 1.07-2.02), and 1.53 (95% CI, 1.21-1.92), respectively. The incidence rates for blood types O, A, AB, and B were 28.9, 39.9, 41.8, and 44.5 cases per 100,000 subjects per year. An increase in risk was noted with the addition of each non-O allele. Compared with OO genotype, subjects with AO and AA genotype had ORs of 1.33 (95% CI, 1.13-1.58) and 1.61 (95% CI, 1.22-2.18), whereas subjects with BO and BB genotypes had ORs of 1.45 (95% CI, 1.14-1.85) and 2.42 (1.28-4.57). The population attributable fraction for non-O blood type was 19.5%. In a joint model with smoking, current smokers with non-O blood type had an adjusted OR of 2.68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk.
Wolpin
Brian M
BM
Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA. bwolpin@partners.org
Kraft
Peter
P
Gross
Myron
M
Helzlsouer
Kathy
K
Bueno-de-Mesquita
H Bas
HB
Steplowski
Emily
E
Stolzenberg-Solomon
Rachael Z
RZ
Arslan
Alan A
AA
Jacobs
Eric J
EJ
Lacroix
Andrea
A
Petersen
Gloria
G
Zheng
Wei
W
Albanes
Demetrius
D
Allen
Naomi E
NE
Amundadottir
Laufey
L
Anderson
Garnet
G
Boutron-Ruault
Marie-Christine
MC
Buring
Julie E
JE
Canzian
Federico
F
Chanock
Stephen J
SJ
Clipp
Sandra
S
Gaziano
John Michael
JM
Giovannucci
Edward L
EL
Hallmans
Göran
G
Hankinson
Susan E
SE
Hoover
Robert N
RN
Hunter
David J
DJ
Hutchinson
Amy
A
Jacobs
Kevin
K
Kooperberg
Charles
C
Lynch
Shannon M
SM
Mendelsohn
Julie B
JB
Michaud
Dominique S
DS
Overvad
Kim
K
Patel
Alpa V
AV
Rajkovic
Aleksandar
A
Sanchéz
Maria-José
MJ
Shu
Xiao-Ou
XO
Slimani
Nadia
N
Thomas
Gilles
G
Tobias
Geoffrey S
GS
Trichopoulos
Dimitrios
D
Vineis
Paolo
P
Virtamo
Jarmo
J
Wactawski-Wende
Jean
J
Yu
Kai
K
Zeleniuch-Jacquotte
Anne
A
Hartge
Patricia
P
Fuchs
Charles S
CS
D000017:ABO Blood-Group System / Q000235:genetics*; D000368:Aged; D000483:Alleles; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010190:Pancreatic Neoplasms / Q000235:genetics*; D012307:Risk Factors
D000017:ABO Blood-Group System