Possible benefits of curcumin regimen in combination with taxane chemotherapy for hormone-refractory prostate cancer treatment.
Complementary and alternative therapies for neoplastic diseases treatment and prevention receive increasing attention from the medical community. Prostate cancer (PC) is the most frequently diagnosed malignancy and the second major cause of male death in industrialized countries. The chemopreventive properties and clinical safety of curcumin, a polyphenolic derivative, have already been established. However, curcumin regimen value in addition to conventional hormone refractory (HR) PC treatment remains largely unknown. This review article summarizes mechanisms by which curcumin may decrease HRPC aggressive proliferation and potentiate activity of taxane therapy. Our analysis suggests that curcumin alone has a therapeutic value in HRPC. In combination with a taxane agent, this compound may enhance cytotoxicity and retard PC cell resistance to taxane. As a consequence, a rationale is provided for considering the possible benefits of curcumin regimen in combination with taxane therapy in HRPC patients.
Cabrespine-Faugeras
Aurelie
A
Hotel-Dieu Pavillon Villemin Pasteur, Clermont-Ferrand, France.
Bayet-Robert
Mathilde
M
Bay
Jacques-Olivier
JO
Chollet
Philippe
P
Barthomeuf
Chantal
C
D016588:Anticarcinogenic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D001952:Bridged-Ring Compounds / Q000008:administration & dosage*; D002453:Cell Cycle / Q000187:drug effects; D003474:Curcumin / Q000008:administration & dosage* / Q000009:adverse effects; D019008:Drug Resistance, Neoplasm; D006728:Hormones; D006801:Humans; D008297:Male; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D043823:Taxoids / Q000008:administration & dosage*
D016588:Anticarcinogenic Agents; D001952:Bridged-Ring Compounds; D006728:Hormones; D043823:Taxoids; C080625:taxane; D003474:Curcumin