title: Octanorcucurbitane triterpenoids protect against tert-butyl hydroperoxide-induced hepatotoxicity from the stems of Momordica charantia.
abstract: Four novel octanorcucurbitane triterpenes, octanorcucurbitacins A-D (1-4), together with one known octanorcucurbitane triterpene, kuguacin M (5), were isolated from the methyl alcohol extract of the stems of Momordica charantia. Their structures were elucidated on the basis of extensive spectroscopic analyses. Compound 3 inhibited tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity against HepG2 cells.
authors.affiliation: Graduate Institute of Biotechnology, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan. changchii@mail.npust.edu.tw
authors.forename: Chi-I
authors.initials: CI
authors.lastname: Chang
authors.forename: Chiy-Rong
authors.initials: CR
authors.lastname: Chen
authors.forename: Yun-Wen
authors.initials: YW
authors.lastname: Liao
authors.forename: Wen-Ling
authors.initials: WL
authors.lastname: Shih
authors.forename: Hsueh-Ling
authors.initials: HL
authors.lastname: Cheng
authors.forename: Chih-Ying
authors.initials: CY
authors.lastname: Tzeng
authors.forename: Jia-Wei
authors.initials: JW
authors.lastname: Li
authors.forename: Ming-Ting
authors.initials: MT
authors.lastname: Kung
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D019610:Cytoprotection; D006027:Glycosides / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D056945:Hep G2 Cells; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D029777:Momordica charantia / Q000737:chemistry*; D014315:Triterpenes / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D020122:tert-Butylhydroperoxide / Q000009:adverse effects*
chemical_list: D006027:Glycosides; D014315:Triterpenes; C514277:cucurbitane; D020122:tert-Butylhydroperoxide