title: Increased excitability and metabolism in pilocarpine induced epileptic rats: effect of Bacopa monnieri.
abstract: We have evaluated the acetylcholine esterase and malate dehydrogenase activity in the muscle, epinephrine, norepinephrine, insulin and T3 content in the serum of epileptic rats. Acetylcholine esterase and malate dehydrogenase activity increased in the muscle and decreased in the heart of the epileptic rats compared to control. Insulin and T3 content were increased significantly in the serum of the epileptic rats. Our results suggest that repetitive seizures resulted in increased metabolism and excitability in epileptic rats. Bacopa monnieri and Bacoside-A treatment prevents the occurrence of seizures there by reducing the impairment on peripheral nervous system.
authors.affiliation: Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Cochin 682 022, Kerala, India.
authors.forename: Jobin
authors.initials: J
authors.lastname: Mathew
authors.forename: Jes
authors.initials: J
authors.lastname: Paul
authors.forename: M S
authors.initials: MS
authors.lastname: Nandhu
authors.forename: C S
authors.initials: CS
authors.lastname: Paulose
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D034681:Bacopa; D002220:Carbamazepine / Q000627:therapeutic use; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D004837:Epinephrine / Q000097:blood; D007328:Insulin / Q000097:blood; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D018721:Muscarinic Agonists; D009206:Myocardium / Q000201:enzymology; D009638:Norepinephrine / Q000097:blood; D008517:Phytotherapy; D010862:Pilocarpine; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000627:therapeutic use*; D014284:Triiodothyronine / Q000097:blood; D014315:Triterpenes / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D007328:Insulin; D018721:Muscarinic Agonists; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C500175:bacoside A; D010862:Pilocarpine; D014284:Triiodothyronine; D002220:Carbamazepine; D008291:Malate Dehydrogenase; D000110:Acetylcholinesterase; D009638:Norepinephrine; D004837:Epinephrine