Anti-inflammatory function of Nodosin via inhibition of IL-2.
In order to explore the anti-inflammatory effects of Nodosin from Isodon serra, a traditional Chinese herb medicine, mouse T lymphocytes were incubated with Nodosin. In the current study, Nodosin suppressed the overproduction of the T lymphocytes; moreover, cell mitosis cycle was modulated by interfering with DNA replication in G1 stages via inhibition of IL-2 cytokine secretion at the mRNA level by Nodosin. Interestingly, Xylene-induced mouse tumescence model results suggested Nodosin depressed the murine ear-swelling extent and the level of IL-2 in the blood serum. Finally, Nodosin possessed significant anti-inflammatory effects and is a potential candidate for further clinical trial.
Li
Jiyu
J
Institute of Department of General Surgery, Xinhua Hospital, Shanghai Jiaotong University, China. leejiyu@sina.com
Du
Junming
J
Sun
Lijuan
L
Liu
Jianwen
J
Quan
Zhiwei
Z
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002453:Cell Cycle / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D004423:Ear; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy / Q000276:immunology; D005260:Female; D007376:Interleukin-2 / Q000037:antagonists & inhibitors* / Q000097:blood; D037602:Isodon / Q000737:chemistry*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D035261:Plant Components, Aerial; D012333:RNA, Messenger / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D014992:Xylenes
D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D012333:RNA, Messenger; D014992:Xylenes; C548830:nodosin