Comorbidity between headache and epilepsy in a pediatric headache center.
The purpose of this study was to analyse the comorbidity between headache and epilepsy in a large series of children with headache (1,795). Fifty-six cases (3.1%) suffered from idiopathic headache and idiopathic or cryptogenic epilepsy or unprovoked seizures. There was a strong association between migraine and epilepsy: in migraineurs (46/56) the risk of epilepsy was 3.2 times higher when compared with tension-type headache, without significant difference between migraine with and without aura (P = 0.89); children with epilepsy had a 4.5-fold increased risk of developing migraine than tension-type headache. In cases with comorbidity, focal epilepsies prevailed (43/56, 76.8%). Migraineurs affected by focal epilepsies (36/56) had a three times higher risk of having a cryptogenic epilepsy (27/36, 75%) than an idiopathic epilepsy (9/36, 25%) (P = 0.003). In migraine with aura, epilepsy preceded migraine in 71% of cases. Photosensitivity (7/56, 12.5%) and positive family history for epilepsy (22/56, 39%) were frequent in cases with comorbidity.
Toldo
Irene
I
Department of Pediatrics, University of Padova, Padua, Italy. irene.toldo@unipd.it
Perissinotto
Egle
E
Menegazzo
Francesca
F
Boniver
Clementina
C
Sartori
Stefano
S
Salviati
Leonardo
L
Clementi
Maurizio
M
Montagna
Pasquale
P
Battistella
Pier Antonio
PA
D000293:Adolescent; D000367:Age Factors; D017668:Age of Onset; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004827:Epilepsy / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology*; D020195:Epilepsy, Reflex / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D020773:Headache Disorders / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology; D006306:Health Surveys; D006776:Hospitals, Pediatric / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007558:Italy / Q000453:epidemiology; D008297:Male; D008881:Migraine Disorders / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology; D015995:Prevalence; D012189:Retrospective Studies; D018781:Tension-Type Headache / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology; D055815:Young Adult