title: [Posterior cortical atrophy. Report of five cases].
abstract: Posterior cortical atrophy (PCA) is a neurodegenerative syndrome, usually due to Alzheimer's disease. The first symptoms are progressive impairment of visuo spatial (Balint's and Gertsmann's syndromes) or visuo perceptive (visual agnosia, alexia) function. Episodic memory and executive function are spared until later stages. We report two males aged 51 and 55years and three females aged 50, 54 and 56 years, with posterior cortical atrophy. Ophthalmologic study was normal in all. Presenting signs and symptoms were visual ataxia, simultagnosia, agraphia, acalculia, spatial disorientation and unilateral neglect (Balint's and Gerstmann's syndromes). Apperceptive visual agnosia, aphasia, apraxia and alexia were also observed. One female had cortical blindness. Structural images were inconclusive, but PET scan and SPECT disclosed functional impairments in occipitotemporal or occipitoparietal areas.
authors.affiliation: Hospital Clínico de la Universidad de Chile. Santiago de Chile.
authors.forename: Carolina
authors.initials: C
authors.lastname: Delgado D
authors.forename: Archibaldo
authors.initials: A
authors.lastname: Donoso S
mesh_terms: D001284:Atrophy / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D003072:Cognition Disorders / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000473:pathology*; D009778:Occipital Lobe / Q000473:pathology; D015835:Ocular Motility Disorders / Q000145:classification / Q000473:pathology; D014796:Visual Perception / Q000502:physiology