title: Health-related quality of life and its determinants in HIV patients with post herpetic neuralgia.
abstract: BACKGROUND
  Postherpetic neuralgia is a neuralgia caused by the varicella zoster virus. Its natural history involves slow resolution of the pain syndrome. A subgroup of patients may develop severe, long-lasting pain that does not respond to medical therapy. It also accounts for 11-15% of all referrals to pain clinics but little is known about the quality of life of patients with this condition in our locality Nigeria.
  
  
  METHODS
  Fifty three Post herpetic Neuralgia patients aged between 25 and 56 years (mean = 37.47 +/- 8.29 years) receiving antiretroviral therapy/treatment at the University of Maiduguri Teaching Hospital, Maiduguri, Nigeria participated in this study. The short-form 36 (SF-36) generic health-related Quality of Life questionnaire was used to assess the QoL. Spearman rank correlation procedure was used to evaluate the relationship of HRQoL outcomes with medical and socio-demographic factor.
  
  
  RESULTS
  Physical functioning), Role limitations due to physical health (LPH), Role limitations due to emotional problems (LEP), Social functioning (SF), General health perceptions (GH) scores were below average (35.59 +/- 19.85, 34.28 +/- 33.16, 33.70 +/- 23.26, 49.07 +/- 17.04, 44.09 +/- 9.72 respectively) while Emotional well being/Mental health (EM) was above average (50.13 +/- 11.56). An average (moderate) symptom scale score was Energy/Fatigue (EF) (51.32 +/- 12.87) while Bodily pain (BP) was severe (31.09 +/- 20.46). Age and sex had no significant influence on any of the functional and symptom scale scores as well as the overall QOL. Inverse relationship was observed between age and each of the LPH, LEP, SF, GH, overall QoL and the entire symptom scales. The overall QoL and each of the symptom scale scores were significantly related (P > 0.05). The functional scale score PF, RPH, REP EM and GH were significantly related to overall QoL while SF was not significantly related (P > 0.01).
  
  
  CONCLUSIONS
  This study has shown that the overall QoL of PHN in HIV positive patients undergoing adjuvant therapy is below average. The predictor factors of the overall QoL of this group of patients have been brought to light. These patients would require ways to improve the QoL, there is the need for health care provider to address the factors uncovered by this study. Four of the determinant factors (PF, LP, BP and EF) are issues that fall within the corridor of physical therapy. Physical therapist should arise to address these significant aspects of the management this group of patients.
authors.affiliation: Department of Physiotherapy, College of Medical Sciences, University of Maiduguri, Maiduguri, Nigeria. sa2edia@yahoo.com
authors.forename: I A
authors.initials: IA
authors.lastname: Saidu
authors.forename: P U
authors.initials: PU
authors.lastname: Bassi
authors.forename: A O
authors.initials: AO
authors.lastname: Jaiyesimi
authors.forename: H A
authors.initials: HA
authors.lastname: Onuwe
authors.forename: A A
authors.initials: AA
authors.lastname: Rufa'l
authors.forename: S M
authors.initials: SM
authors.lastname: Maduagwu
authors.forename: A M
authors.initials: AM
authors.lastname: Jajere
authors.forename: A M
authors.initials: AM
authors.lastname: Ahmed
authors.forename: A H
authors.initials: AH
authors.lastname: Gabdo
authors.forename: A O
authors.initials: AO
authors.lastname: Akanbi
authors.forename: O A
authors.initials: OA
authors.lastname: Jaiyeola
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D015497:HIV-1; D006304:Health Status; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D051474:Neuralgia, Postherpetic / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D011581:Psychological Tests; D011594:Psychometrics; D011788:Quality of Life / Q000523:psychology; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D044966:Anti-Retroviral Agents