Relation between 25(OH)-vitamin D deficiency and markers of bone formation and resorption in haemodialysis patients.
Deficient serum 25-hydroxyvitamin D [25(OH)D] may contribute to the impaired bone turnover of end stage renal disease patients. In 112 hemodialysed patients we analysed the relation between 25(OH)D and bone alkaline phosphatase (BALP), beta-CrossLaps (beta-CTx) and iPTH. We analysed parameters according to the manufacturers' instructions. We found potentially significant vitamin D deficiency: 71% of patients had 25(OH)D levels below 50 nmol/L. In patients with iPTH below 150 pg/mL (n = 57), we observed significantly low 25(OH) (p < 0.01). In addition, patients with iPTH above 300 pg/mL had higher BALP levels (p < 0.05). There were negative correlations between serum 25(OH)D and both BALP and iPTH (r = -0.225, p < 0.05 and r = -0.331, p < 0.05). Beta-CTx levels were significantly higher in patients who did not receive vitamin D supplementation (p < 0.01). In addition, reduced BALP and iPTH levels indicate decreased bone turnover. Recorded data could signify that vitamin D deficiency may contribute to the impaired bone metabolism of hemodialysis patients.
Milinković
Neda Lj
NLj
Institute of Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia. nedanvkvc@yahoo.com
Majkić-Singh
Nada T
NT
Mirković
Dusko D
DD
Beletić
Andjelo D
AD
Pejanović
Svetlana D
SD
Vujanić
Svetlana T
ST
D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism*; D001862:Bone Resorption / Q000378:metabolism*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000378:metabolism*; D024042:Collagen Type I / Q000378:metabolism; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010012:Osteogenesis / Q000502:physiology*; D010281:Parathyroid Hormone / Q000378:metabolism; D010455:Peptides / Q000378:metabolism; D012016:Reference Values; D006435:Renal Dialysis; D014808:Vitamin D Deficiency / Q000175:diagnosis / Q000378:metabolism*
D015415:Biomarkers; D024042:Collagen Type I; D010281:Parathyroid Hormone; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D000469:Alkaline Phosphatase