The effects of synthetic organoselenium compounds on nitric oxide in DMBA-induced rat liver.
DMBA (7, 12-dimethylbenz[a]anthracene) is known to generate DNA-reactive species during their metabolism, which may enhance oxidative stress in cells. Since selenium is known as a non-enzymic antioxidant, health problems induced by many environmental pollutants, have stimulated the evaluation of relative antioxidant potential of selenium and synthetic organoselenium compounds. Therefore, we aimed to evaluate chemopreventive potential of synthetic organoselenium compounds by monitoring level of liver nitric oxide. In this study, adult female Wistar rats were treated with DMBA and the novel organoselenium compounds (Se I) and (Se II) in the determined doses. DMBA-induced in rats, the effects of organoselenium compounds on nitric oxide levels in rat liver was studied. In this study it has been observed a statistically significant increase in (Nitric Oxide) levels for the liver of rat exposed to DMBA (p<0.05). However with administration of Se I and Se II there was a statistically significant decrease in NO levels (p<0.05). The ability of the organoselenium compounds to prevent oxidative damage induced by DMBA in rat livers was rationalized. Protection against nitric oxide measured in Se I and Se II treated groups were provided by synthesized organoselenium compounds. Se I and Se II both provided chemoprevention against DMBA-induced oxidative stress in rat liver.
Talas
Zeliha Selamoglu
ZS
Department of Biology, Faculty of Arts and Science, Nigde University, Nigde-51100, Turkey.
Bayraktar
Nihayet
N
Ozdemir
Ilknur
I
Gok
Yetkin
Y
Yilmaz
Ismet
I
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D008099:Liver / Q000187:drug effects*; D009569:Nitric Oxide / Q000378:metabolism*; D016566:Organoselenium Compounds / Q000737:chemistry / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D020011:Protective Agents / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism
C526938:1,3-di-p-methoxybenzylpyrimidine-2-selenone; C526937:1-isopropyl-3-methylbenzimidazole-2-selenone; D000975:Antioxidants; D001562:Benzimidazoles; D016566:Organoselenium Compounds; D020011:Protective Agents; D011743:Pyrimidines; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D015127:9,10-Dimethyl-1,2-benzanthracene