Current status of oxidative stress in pediatric liver transplantation.
Generation of free radicals in children after liver transplantation is multifactorial from ischemia-reperfusion injury, immunosuppression and post-transplant complications. Thus, this group is at higher risk of oxidative imbalance with molecular and clinical consequences. We discuss pathogenesis and ways of action against oxidative stress in liver transplant recipients.
Czubkowski
Piotr
P
Department of Gastroenterology, Hepatology and Immunology, The Children's Memorial Health Institute, Warsaw, Poland. piotr.czubkowski@mp.pl
Socha
Piotr
P
Pawlowska
Joanna
J
D000975:Antioxidants / Q000627:therapeutic use; D002648:Child; D015316:Genetic Therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D019194:Ischemic Preconditioning; D016031:Liver Transplantation / Q000009:adverse effects* / Q000502:physiology; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy
D000975:Antioxidants; D007166:Immunosuppressive Agents; D017382:Reactive Oxygen Species