Cytotoxic chemical constituents from the roots of Cimicifuga foetida. [corrected].
Seven new 9,19-cycloartane triterpene glycosides, 25-O-acetylcimigenol-3-O-[2'-O-(E)-2-butenoyl]-beta-d-xylopyranoside (1), 25-O-acetylcimigenol-3-O-[4'-O-(E)-2-butenoyl]-beta-d-xylopyranoside (2), 25-O-acetylcimigenol-3-O-[3'-O-acetyl]-beta-d-xylopyranoside (3), 25-O-acetylcimigenol-3-O-[4'-O-acetyl]-beta-d-xylopyranoside (4), 25-O-acetyl-12beta-acetoxycimigenol-3-O-beta-d-xylopyranoside (5), 3'-O-acetylactein (6), and 3'-O-acetyl-23-epi-26-deoxyactein (7), together with eight known compounds (8-15), were isolated from the roots of Cimicifuga fetida. Their structures were established by spectroscopic and chemical methods. Most of these compounds showed more selective and higher cytotoxicity against the human HepG2 cell line than against the MCF7, HT29, and MKN28 cell lines. Compounds 2, 3, and 7 exhibited significant cytotoxicity against HepG2 cells, with IC(50) values of 1.29, 0.71, and 1.41 microM, respectively.
Nian
Yin
Y
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Zhang
Yan-Li
YL
Chen
Jian-Chao
JC
Lu
Lu
L
Qiu
Ming-Hua
MH
Qing
Chen
C
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031885:Cimicifuga / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019073:HT29 Cells; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D014315:Triterpenes