Patient with eight metachronous gastrointestinal cancers thought to be hereditary nonpolyposis colorectal cancer (HNPCC).
An 81-year-old woman presented with a chief complaint of swelling of both lower legs. She had a history of surgery for cancers of the stomach, rectum and colon. Among her immediate family members, her son had colon and rectal cancers, and her sister had ovarian cancer. After close examination the patient was diagnosed with small intestine cancer and ascending colon cancer. Gene mutation analyses did not reveal any mutations in DNA mismatch repair genes, but MSH-2 protein expression was lost only in the cancer lesions. Here, we report this rare case of eight metachronous gastrointestinal cancers thought to be HNPCC.
Yamasaki
Yasushi
Y
Department of Internal Medicine, Tokai University School of Medicine, Isehara.
Matsushima
Masashi
M
Tanaka
Hisae
H
Tajiri
Sakurako
S
Fukuda
Ryuki
R
Ozawa
Hideki
H
Takagi
Atsushi
A
Hirabayashi
Ken-ichi
K
Sadahiro
Sohtaro
S
D000369:Aged, 80 and over; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D051718:MutS Homolog 2 Protein / Q000032:analysis*; D016609:Neoplasms, Second Primary / Q000175:diagnosis*
C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein