title: [Cardiac dyssynchrony correlates with left ventricular remodeling after myocardial Infarction].
abstract: BACKGROUND
  Cardiac dyssynchrony is common in advanced heart failure (HF), but the changes in cardiac synchrony after myocardial infarction (MI) have not been adequately descríbed.
  
  
  OBJECTIVE
  To study the relationship between cardiac synchrony and left ventricular remodeling after acute myocardial infarction.
  
  
  METHODS
  Forty nine patients aged 59+/-10 years (77% men) with a first episode of a ST segment elevation MI, were studied. Scintigraphic left ventricular function and synchrony analyses were performed at baseline and after a six months follow-up. Determinations were compared with 33 healthy subjects.
  
  
  RESULTS
  At baseline, patients with MIhad a decreased left ventricular ejection fraction (LVEF) and significant dyssynchrony, when compared with controls. LVEF was 36.4%+/-10%, left ventricular end-diastolic volume (LVEDV) 127+/-38 mL, interventricular delay (IEV) 29+/-35 miliseconds (ms), and intraventricular delay (IAV), 234+/-89 ms. After 6 months, LVEF significantly improved (38%+/-10%, p =0.042) without significant changes in LVEDV (129+/-32 mL, p =0.97), IEV (24+/-17, p =0.96) or IAV (231+/-97, p =0.34). At baseline there were significant correlations between IAV and LVEF, and between IAV and LVEDV (r =0.48, p =0.001 and r =0.41, p =0.004, respectively). These correlations remained significant after 6 months. There was a positive correlation between IAV and LVEDV changes at six months (r =0.403, p =0.04).
  
  
  CONCLUSIONS
  The development of cardiac dyssynchrony correlates with adverse left ventricular remodeling after MI .
authors.affiliation: Departamento de Enfermedades Cardiovasculares, Pontificia Universidad de Catolica de Chile, Santiago, Chile.
authors.forename: Paul
authors.initials: P
authors.lastname: McNab
authors.forename: Pablo
authors.initials: P
authors.lastname: Castro
authors.forename: Luigi
authors.initials: L
authors.lastname: Gabrielli
authors.forename: Hugo
authors.initials: H
authors.lastname: Verdejo
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Quintana
authors.forename: José A
authors.initials: JA
authors.lastname: Rodríguez
authors.forename: Ramón
authors.initials: R
authors.lastname: Corbalán
mesh_terms: D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology; D011877:Radionuclide Imaging; D013318:Stroke Volume / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D020257:Ventricular Remodeling / Q000502:physiology*