title: Ultrasonographic guided axillary plexus blocks with low volumes of local anaesthetics: a crossover volunteer study.
abstract: Our study group recently evaluated an ED(95) local anaesthetic volume of 0.11 ml.mm(-2) cross-sectional nerve area for the ulnar nerve. This prospective, randomised, double-blind crossover study investigated whether this volume is sufficient for brachial plexus blocks at the axillary level. Ten volunteers received an ultrasonographic guided axillary brachial plexus block either with 0.11 ('low' volume) or 0.4 ('high' volume) ml.mm(-2) cross-sectional nerve area with mepivacaine 1%. The mean (SD) volume was in the low volume group 4.0 (1.0) and 14.8 (3.8) ml in the high volume group. The success rate for the individual nerve blocks was 27 out of 30 in the low volume group (90%) and 30 out of 30 in the high volume group (100%), resulting in 8 out of 10 (80%) vs 10 out of 10 (100%) complete blocks in the low vs the high volume groups, respectively (NS). The mean (SD) sensory onset time was 25.0 (14.8) min in the low volume group and 15.8 (6.8) min in the high volume group (p < 0.01). The mean (SD) duration of sensory block was 125 (38) min in the low volume group and 152 (70) min in the high volume group (NS). This study confirms our previous published ED(95) volume for mepivacaine 1% to block peripheral nerves. The volume of local anaesthetic has some influence on the sensory onset time.
authors.affiliation: Medical University of Vienna. peter.marhofer@meduniwien.ac.at
authors.forename: P
authors.initials: P
authors.lastname: Marhofer
authors.forename: U
authors.initials: U
authors.lastname: Eichenberger
authors.forename: S
authors.initials: S
authors.lastname: Stöckli
authors.forename: G
authors.initials: G
authors.lastname: Huber
authors.forename: S
authors.initials: S
authors.lastname: Kapral
authors.forename: M
authors.initials: M
authors.lastname: Curatolo
authors.forename: S
authors.initials: S
authors.lastname: Kettner
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage*; D001365:Axilla; D015992:Body Mass Index; D001917:Brachial Plexus; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D006801:Humans; D008475:Median Nerve / Q000000981:diagnostic imaging; D009407:Nerve Block / Q000379:methods*; D011446:Prospective Studies; D011826:Radial Nerve / Q000000981:diagnostic imaging; D012677:Sensation / Q000187:drug effects; D014459:Ulnar Nerve / Q000000981:diagnostic imaging; D018084:Ultrasonography, Interventional / Q000379:methods; D055815:Young Adult
chemical_list: D000779:Anesthetics, Local