[Markers of the course of inflammatory bowel disease treated with immunomodulators or biological agents].
Immunosuppressive or biological treatment in patients with inflammatory bowel disease can modify the natural history of their disease, although these treatments are not universally effective and can have severe adverse effects. Attempts have been made to identify predictive factors of response to the various therapeutic options in order to aid the choice of the most appropriate therapeutic alternative in each patient. The possibility of modifying any one of these predictive factors would be of great interest since it would provide the opportunity to alter the course of the disease. Epidemiological, biological, clinical, endoscopic, radiological, genetic and even proteomic markers have been studied, in addition to others related to the disease itself or to specific treatments. The present article briefly discusses the real use of each of these markers and the evidence supporting their utility.
González-Lama
Yago
Y
Unidad de Enfermedad Inflamatoria Intestinal, Servicio de Gastroenterología y Hepatología, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España.
Vera
María Isabel
MI
Calvo
Marta
M
Abreu
Lluís
L
D000367:Age Factors; D001688:Biological Products / Q000627:therapeutic use*; D015415:Biomarkers; D002097:C-Reactive Protein / Q000032:analysis; D016903:Drug Monitoring; D016145:Endoscopy, Digestive System; D005243:Feces / Q000737:chemistry; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D007412:Intestinal Fistula / Q000209:etiology; D007413:Intestinal Mucosa / Q000473:pathology; D011859:Radiography; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
D001688:Biological Products; D015415:Biomarkers; D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D002097:C-Reactive Protein