Blumeaenes A-J, sesquiterpenoid esters from Blumea balsamifera with NO inhibitory activity.
Chemical examination of the ethanol extract of the aerial parts of Blumea balsamifera led to the isolation of ten new sesquiterpenoid esters, blumeaenes A-J (1- 10), with 13 known flavonoids. Their structures were determined mainly by use of 1D and 2D NMR spectroscopic techniques. All sesquiterpenoid esters were tested for their inhibitory activity against LPS-induced NO production in RAW264.7 macrophages. Compounds 1, 4 and 5 showed slight inhibitory effect on the production of NO with IC(50) values of 40.06, 46.35 and 57.80 microg/mL, respectively.
Chen
Ming
M
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P R China.
Qin
Jiang-Jiang
JJ
Fu
Jian-Jun
JJ
Hu
Xiao-Jia
XJ
Liu
Xiao-Hua
XH
Zhang
Wei-Dong
WD
Jin
Hui-Zi
HZ
D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D002460:Cell Line; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
D008070:Lipopolysaccharides; D010936:Plant Extracts; D012717:Sesquiterpenes; D009569:Nitric Oxide