The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery.
To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery.



Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery.



There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02).



Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.
Cooley
Sharon M
SM
Rotunda Hospital, Parnell Street, Dublin 1, Ireland. smcooley@hotmail.com
Donnelly
Jennifer C
JC
Collins
Claire
C
Geary
Michael P
MP
Rodeck
Charles H
CH
Hindmarsh
Peter C
PC
D000328:Adult; D000428:Alcohol Drinking; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D007335:Insulin-Like Growth Factor II / Q000032:analysis*; D011247:Pregnancy; D047928:Premature Birth / Q000097:blood*; D011446:Prospective Studies; D012907:Smoking
D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II