Sesquiterpenoids from the formosan soft coral Sinularia leptoclados.
Chemical investigation of the soft coral Sinularia leptoclados has afforded three new sesquiterpenoids, leptocladols A (1), B (2), and 1-epi-chabrolidione A (3). The relative structures of 1-3 were determined on the basis of extensive spectroscopic analysis. The relative configuration of 1 was further confirmed by a single-crystal X-ray diffraction analysis.
Su
Jui-Hsin
JH
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Chiang
Michael Y
MY
Wen
Zhi-Hong
ZH
Dai
Chang-Feng
CF
Hsu
Chi-Hsin
CH
Sheu
Jyh-Horng
JH
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008958:Models, Molecular; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D014961:X-Ray Diffraction
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D008070:Lipopolysaccharides; D012717:Sesquiterpenes