[Genetics of atrial fibrillation].
Atrial fibrillation is the most common cardiac arrhythmia. The identification of familial forms of atrial fibrillation as well as epidemiological studies have confirmed the presence of a genetic background. Familial forms are rare diseases, and the common form is a multifactorial and probably multigenic disease largely modulated by environmental factors. New research developments, based on GWAS studies of well define large cohorts, should, in the near future, help to better characterize the different genetic profiles of this disease, the first step for the identification of new therapeutic targets.
Le Marec
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Département de Cardiologie, Hôpitaux de Brabois, Allée du Morvan, 54511 Vandoeuvre lès Nancy, France. herve.lemarec@chu-nantes.fr
Probst
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D001281:Atrial Fibrillation / Q000235:genetics*; D006801:Humans