title: Species specific thyroid signal transduction: conserved physiology, divergent mechanisms.
abstract: In the literature, data obtained in signal transduction from various species thyroids and cells lines are often integrated in a common model. We investigate qualitatively and systematically, using the same protocol, the control by TSH of the two main functions of the thyrocytes, the synthesis and the secretion of thyroid hormones. In all species investigated, the TSH receptor activates both. In some species, including humans, rats and mice, the TSH receptor activates both the cAMP and phospholipase C-PIP2 cascades, in others (e.g. dog) it only stimulates the first. The cAMP pathway activates the limiting step in thyroid hormones synthesis, the generation of H(2)O(2), in dog, rat and mice but not in human, pig, horse and beef. Thus although the physiological result of TSH action is the same in all species, the signaling pathways used are different. Other distinctions in signaling are observed such as the relative effects of one cascade on the other.
authors.affiliation: Institute of Interdisciplinary Research (IRIBHM), School of Medicine, Université Libre de Bruxelles, Campus Erasme Hospital, Brussels, Belgium.
authors.forename: Y
authors.initials: Y
authors.lastname: Song
authors.forename: C
authors.initials: C
authors.lastname: Massart
authors.forename: V
authors.initials: V
authors.lastname: Chico-Galdo
authors.forename: L
authors.initials: L
authors.lastname: Jin
authors.forename: V
authors.initials: V
authors.lastname: De Maertelaer
authors.forename: C
authors.initials: C
authors.lastname: Decoster
authors.forename: J E
authors.initials: JE
authors.lastname: Dumont
authors.forename: J
authors.initials: J
authors.lastname: Van Sande
mesh_terms: D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000502:physiology; D004285:Dogs; D006736:Horses; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D051379:Mice; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000502:physiology; D010740:Phospholipases / Q000502:physiology; D051381:Rats; D011989:Receptors, Thyrotropin / Q000502:physiology*; D012756:Sheep; D015398:Signal Transduction / Q000502:physiology*; D013045:Species Specificity; D013552:Swine; D013961:Thyroid Gland / Q000502:physiology*; D013963:Thyroid Hormones / Q000502:physiology
chemical_list: D019269:Phosphatidylinositol 4,5-Diphosphate; D011989:Receptors, Thyrotropin; D013963:Thyroid Hormones; D006861:Hydrogen Peroxide; D000242:Cyclic AMP; D010740:Phospholipases