title: Taking a lesson from microbial diarrheagenesis in the management of chronic constipation.
authors.forename: Adil E
authors.initials: AE
authors.lastname: Bharucha
authors.forename: Scott A
authors.initials: SA
authors.lastname: Waldman
mesh_terms: D000284:Administration, Oral; D002908:Chronic Disease; D003248:Constipation / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D003672:Defecation / Q000187:drug effects; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy* / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D005765:Gastrointestinal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D010455:Peptides / Q000008:administration & dosage* / Q000009:adverse effects; D011788:Quality of Life; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005765:Gastrointestinal Agents; D010455:Peptides; C523483:linaclotide