Influence of chemoresistance and p53 status on fluoro-2-deoxy-D-glucose incorporation in cancer.
Both mutant p53 and chemoresistance are poor prognostic factors in cancer. Many studies have examined the influence of these factors on fluoro-2-deoxy-D-glucose (FDG) incorporation. Whilst mutant p53 is associated with increased FDG incorporation, chemoresistance, especially when associated with P-glycoprotein, is associated with decreased FDG incorporation.
Smith
Tim A D
TA
School of Medical Sciences (Biomedical Physics), University of Aberdeen, Foresterhill, Aberdeen, UK. t.smith@abdn.ac.uk
D000818:Animals; D001692:Biological Transport; D019008:Drug Resistance, Neoplasm; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D011379:Prognosis; D011877:Radionuclide Imaging; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53; D019788:Fluorodeoxyglucose F18