Synthesis, spectral characterization and bioassay of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxa-phosphinines].
Synthesis of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxaphos-phinines] (3a-j) were accomplished via two step process. It involves the prior preparation of monochloride intermediate (2) and its subsequent reaction with the amino acid esters in dry tetrahydrofuran-toluene in the presence of triethylamine at reflux temperature. These compounds were characterized by IR, 1H, 13C, 31P NMR and were found to exhibit potent in vitro antioxidant activity.
Veera Narayana Reddy
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M
Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh 517 502, India.
Bala krishna
A
A
Suresh Reddy
C
C
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002374:Catalase / Q000037:antagonists & inhibitors*; D005978:Glutathione / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors*
D000975:Antioxidants; D001555:Benzene Derivatives; D009943:Organophosphorus Compounds; C519090:phosphinine; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione