Evaluation of teratogenic potential of cyfluthrin, a synthetic pyrethroid in Swiss albino mice.
A toxicity study was planned to assess the teratogenic potential of cyfluthrin that is widely used as a household insecticide to control mosquitoes, flies and cockroaches. Pregnant Swiss albino mice of one group were orally administered two doses of the pesticide (16 mg/kg and 32 mg/kg body weight) daily during the organogenetic phase (days 5-14) of gestation. The second group received the same two doses daily during the maturation phase (days 14-18) of gestation. The animals receiving the higher dose exhibited burrowing behaviour, which is a characteristic symptom of pyrethroid poisoning. The autopsies were performed on the 18th day of gestation and routine teratological observations were made. No external malformations occurred in any of the fetus. The higher dose significantly reduced the number of live fetuses, litter size and increased the resorption of embryos when administered during organogenesis, while exposure to the pesticide during the maturation phase did not significantly affect the reproductive parameters. During both the phases, the higher dose reduced the maternal weight gain and the average weight of the fetuses. The fetal anomalies observed were reduced ossification of skull bones, widened cranial sutures, short or absent ribs, hydrocephaly of the ventricles, microphthalmia, anophthalmia, pulmonary edema and subcutaneous edema.
Syed
Farah
F
Environmental Toxicology Laboratory, Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Rajasthan, India. syedf3_02@yahoo.co.in
Soni
Inderpal
I
John
P J
PJ
Bhatnagar
Pradeep
P
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001842:Bone and Bones / Q000002:abnormalities / Q000187:drug effects / Q000196:embryology / Q000473:pathology; D005260:Female; D005298:Fertility / Q000187:drug effects; D008297:Male; D051379:Mice; D009570:Nitriles / Q000633:toxicity*; D011247:Pregnancy; D011722:Pyrethrins / Q000633:toxicity*; D018709:Statistics, Nonparametric; D013723:Teratogens / Q000633:toxicity*; D018675:Toxicity Tests / Q000379:methods
D009570:Nitriles; D011722:Pyrethrins; D013723:Teratogens; C052570:cyfluthrin