[Serum androgen concentrations and bone mineral density in postmenopausal ovariectomized and non-ovariectomized women].
OBJECTIVE
Compare levels of androgens and bone mineral density (BMD) of ovariectomized (OVX) and non-ovariectomized (NOVX) postmenopausal women. Forty women, 20 OVX and 20 NOVX, (53.9 +/- 4 years) were selected.


METHODS
Total testosterone (TT), free testosterone (FT), androstenedione (AN), dehidroepiandrostenedione (DHEA) and its sulfate (DHEA-S) were measured. BMD was measured in 14 OVX and 16 NOVX.


RESULTS
No differences between groups with regard to age, body mass index (BMI) and time since menopause were found. Mean levels of TT and FT were two-fold higher in NOVX group (60.91 versus 30.17 ng/dL, p = 0.0001; 1.00 versus 0.48 pg/mL, p = 0.003). BMD was not different between groups. Inverse correlations were found between BMI and TT (r = -0.3; p = 0.05); time since menopause and AN (r = -0.35; p = 0.02) and time since menopause and DHEA (r = -0.3; p = 0.01).


CONCLUSIONS
Bilateral ovariectomy leads to a more severe androgen deficiency than natural menopause in postmenopausal women and did not compromise bone mass.
Kulak
Jaime
J
Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil. jkulak@ufpr.br
Urbanetz
Almir Antônio
AA
Kulak
Carolina Aguiar Moreira
CA
Borba
Victória Zegbi Cochenski
VZ
Boguszewski
César Luiz
CL
D000728:Androgens / Q000097:blood*; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010052:Ovariectomy; D017698:Postmenopause / Q000097:blood / Q000502:physiology*; D018709:Statistics, Nonparametric
D000728:Androgens