Therapy with FasL-gene-modified dendritic cells confers a protective microenvironment in murine pregnancy.
Analysis of the expression of FasL in the local decidua of pregnant mice and examination of the apoptosis of T cells in peripheral blood and local decidua indicated that adoptive transference of FasL-gene-modified dendritic cells may induce pregnancy immune tolerance by increasing FasL expression in the maternal-fetal interface and inducing the apoptosis of T cells in local decidua but not the peripheral blood.
Xiong
Miao
M
Department of Obstetrics and Gynecology, Shanghai Pudong New Area Gongli Hospital, Shanghai, People's Republic of China.
Lu
Jihong
J
Zhao
Aimin
A
Xu
Liang
L
Bao
Shimin
S
Lin
Qide
Q
Yang
Binlie
B
D019264:Adoptive Transfer; D000818:Animals; D017209:Apoptosis; D003656:Decidua / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology / Q000502:physiology*; D053222:Fas Ligand Protein / Q000096:biosynthesis / Q000502:physiology*; D005260:Female; D051379:Mice; D011247:Pregnancy; D013601:T-Lymphocytes / Q000473:pathology
D053222:Fas Ligand Protein; C505658:Fasl protein, mouse