title: Host factor Ebp1 inhibits rinderpest virus transcription in vivo.
abstract: ErbB3 binding protein Ebp1 has been shown to downregulate ErbB3 receptor-mediated signaling to inhibit cell proliferation. Rinderpest virus belongs to the family Paramyxoviridae and is characterized by the presence of a non-segmented negative-sense RNA genome. In this work, we show that rinderpest virus infection of Vero cells leads to the down-regulation of the host factor Ebp1, at both the mRNA and protein levels. Ebp1 protein has been shown to co-localize with viral inclusion bodies in infected cells, and it is packaged into virions, presumably through its interaction with the N protein or the N-RNA itself. Overexpression of Ebp1 inhibits viral transcription and multiplication in infected cells, suggesting that a mutual antagonism operates between host factor Ebp1 and the virus.
authors.affiliation: Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
authors.forename: M
authors.initials: M
authors.lastname: Gopinath
authors.forename: S
authors.initials: S
authors.lastname: Raju
authors.forename: A
authors.initials: A
authors.lastname: Honda
authors.forename: M S
authors.initials: MS
authors.lastname: Shaila
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000096:biosynthesis*; D000818:Animals; D002522:Chlorocebus aethiops; D015536:Down-Regulation; D015870:Gene Expression; D012302:Rinderpest virus / Q000472:pathogenicity*; D014709:Vero Cells
chemical_list: D048868:Adaptor Proteins, Signal Transducing