title: Small molecule probes that target Abl kinase.
abstract: Two different strategies, namely a dialdehyde-based cross-linking and photo-affinity labeling, have been developed to generate small molecule activity-based probes (ABPs) for the Abelson (Abl) tyrosine kinase, of which probe 13, derived from the photo-affinity approach, showed specific labeling of Abl kinase present in a crude mammalian proteome.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors.forename: Karunakaran A
authors.initials: KA
authors.lastname: Kalesh
authors.forename: Derek S B
authors.initials: DS
authors.lastname: Sim
authors.forename: Jigang
authors.initials: J
authors.lastname: Wang
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.forename: Qingsong
authors.initials: Q
authors.lastname: Lin
authors.forename: Shao Q
authors.initials: SQ
authors.lastname: Yao
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000595:Amino Acid Sequence; D020134:Catalytic Domain; D005456:Fluorescent Dyes / Q000737:chemistry; D016315:Proto-Oncogene Proteins c-abl / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D000447:Aldehydes; D005456:Fluorescent Dyes; D011725:Pyridines; D011994:Recombinant Proteins; D016315:Proto-Oncogene Proteins c-abl