Scalable synthesis of cryptophane-1.1.1 and its functionalization.
Cryptophanes, cage molecules for which xenon exhibits a high affinity, are good candidates for xenon biosensing. Cryptophane-1.1.1 (1) exhibits the highest binding constant for xenon encapsulation in organic solution determined to date. This property suggests that the cryptophane-1.1.1 core (1) is optimal for sensing applications. A high-yielding scalable synthesis of compound 1 is reported as well as an easy way to functionalize it.
Traoré
Ténin
T
CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, Gif sur Yvette, F-91191, France.
Delacour
Léa
L
Garcia-Argote
Sébastien
S
Berthault
Patrick
P
Cintrat
Jean-Christophe
JC
Rousseau
Bernard
B
D019281:Dimerization; D019800:Phenol / Q000737:chemistry; D011083:Polycyclic Compounds; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D014978:Xenon / Q000032:analysis* / Q000737:chemistry*
D011083:Polycyclic Compounds; D014230:Triazoles; C523242:cryptophane; D019800:Phenol; D014978:Xenon