Palmadorins A--C, diterpene glycerides from the antarctic nudibranch Austrodoris kerguelenensis.
The nudibranch Austrodoris kerguelenensis is distributed widely around the Antarctic coast and continental shelves. Earlier collections from McMurdo Sound and the Weddell Sea shelf have afforded a suite of diterpene glyceride esters, a compound class implicated as a chemical defense in nudibranchs. The present chemical investigation of A. kerguelenensis collected near Palmer Station on the Western Antarctic Peninsula has revealed additional examples, palmadorins A-C (1-3), as the first three members of a new series of clerodane diterpenes. In this paper we describe their isolation, structure elucidation, and stereochemical analysis using a combination of one- and two-dimensional NMR spectroscopy and wet chemical methods.
Diyabalanage
Thushara
T
Department of Chemistry and Center for Molecular Diversity in Drug Design, Discovery and Delivery, University of South Florida, Tampa, Florida 33620, USA.
Iken
Katrin B
KB
McClintock
James B
JB
Amsler
Charles D
CD
Baker
Bill J
BJ
D000818:Animals; D000864:Antarctic Regions; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D049851:Gastropoda / Q000737:chemistry*; D005989:Glycerides / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D004224:Diterpenes; D005989:Glycerides; C548926:palmadorin A; C548927:palmadorin B; C548928:palmadorin C