title: Bone marrow biopsy in patients with hepatitis C virus infection: spectrum of findings and diagnostic utility.
abstract: Patients with hepatitis C virus (HCV) infection develop a number of hematologic disorders, with benign and malignant B-cell proliferations being the most common. HCV-infected patients are also prone to developing peripheral cytopenias, the etiologies of which are multifactorial and include hypersplenism and/or antiviral medications. Some of these patients may undergo bone marrow biopsy but no study has systematically recorded the bone marrow findings in this patient group. Here, we report on the range of bone marrow findings in 47 adult HCV-infected patients. These patients, who lacked concurrent human immunodefiency virus (HIV) infection, most commonly presented for a bone marrow biopsy due to abnormal peripheral cell counts. The bone marrow biopsies displayed a range of findings. Dyserythropoiesis, present in 19% of the cases, was the most common finding. Patients with pancytopenia(n = 6), as defined by current World Health Organization standards, were the most likely to have bone marrow abnormalities; two pancytopenic patients had acute myeloid leukemia, and one patient had a primary myelodysplastic syndrome. There was no correlation in bone marrow findings and antiviral medications, MELD score, cirrhosis or splenomegaly, suggesting that the degree of bone marrow dysfunction is independent of stage of HCV. The results of this study suggest that bone marrow biopsy in HCV-infected patients, even those with features of hypersplenism and/or documented antiviral therapy, can be a valid test for hematologic evaluation, especially for patients with severe pancytopenia and/or sudden alterations in peripheral cell counts.
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA.
authors.forename: Jeffery M
authors.initials: JM
authors.lastname: Klco
authors.forename: Bob
authors.initials: B
authors.lastname: Geng
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Brunt
authors.forename: Anjum
authors.initials: A
authors.lastname: Hassan
authors.forename: Tu-Dung
authors.initials: TD
authors.lastname: Nguyen
authors.forename: Friederike H
authors.initials: FH
authors.lastname: Kreisel
authors.forename: Mauricio
authors.initials: M
authors.lastname: Lisker-Melman
authors.forename: John L
authors.initials: JL
authors.lastname: Frater
mesh_terms: D000328:Adult; D001706:Biopsy; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology*; D004920:Erythropoiesis; D005260:Female; D016174:Hepacivirus; D006526:Hepatitis C / Q000097:blood / Q000150:complications / Q000473:pathology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D010198:Pancytopenia / Q000097:blood / Q000473:pathology*; D012189:Retrospective Studies