title: Rosai-Dorfman disease of the nasal cavities: A CO(2) laser excision.
abstract: BACKGROUND
  Rosai-Dorfman disease (RDD) is a rare nonneoplastic histiocytic proliferative disorder characterized by painless massive lymphadenopathy. Extranodal manifestations frequently occur in the head and neck area.
  
  
  METHODS
  We report the clinical and histological features of nasal cavities and cervical lymph node RDD in a 72-year-old woman, who complained of major nasal obstruction and hyposmia.
  
  
  RESULTS
  Nasal endoscopy revealed polypoid masses arising from the turbinates; the septum was intact. Immunohistochemical analysis revealed staining for S-100 protein, CD68, and alpha-1 antitrypsin. The presence of the Epstein-Barr virus was revealed by serology and also by in situ hybridization. The general examination and systemic evaluation did not find other extranodal localization.
  
  
  CONCLUSIONS
  Because the disease is known for not responding to local or systemic steroids, CO(2) laser excision was used to clear the nasal obstruction with a satisfactory result. This is, to the best of our knowledge, the first description of the use of laser excision for nasal cavities RDD.
authors.affiliation: Department of Ear, Nose, and Throat, Farhat Hached University Hospital, Sousse, Tunisia. belcadhi@yahoo.fr
authors.forename: Malek
authors.initials: M
authors.lastname: Belcadhi
authors.forename: Mouna
authors.initials: M
authors.lastname: Bellakhdhar
authors.forename: Badreddine
authors.initials: B
authors.lastname: Sriha
authors.forename: Kamel
authors.initials: K
authors.lastname: Bouzouita
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000276:immunology / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology / Q000378:metabolism; D004351:Drug Resistance; D005260:Female; D015618:Histiocytosis, Sinus / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D053685:Laser Therapy; D054020:Lasers, Gas / Q000706:statistics & numerical data; D009296:Nasal Cavity / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D015508:Nasal Obstruction; D009298:Nasal Polyps; D009418:S100 Proteins / Q000276:immunology / Q000378:metabolism; D013256:Steroids / Q000627:therapeutic use; D000515:alpha 1-Antitrypsin / Q000276:immunology / Q000378:metabolism; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009418:S100 Proteins; D013256:Steroids; D000515:alpha 1-Antitrypsin; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C043392:SERPINA1 protein, human