Breaking the vicious circle of obesity: the metabolic syndrome and low testosterone by administration of testosterone to a young man with morbid obesity.
OBJECTIVE
The metabolic syndrome (MS) is associated with low serum testosterone levels. Conversely, low testosterone levels induce MS. These operational mechanisms reinforce one another and induce a vicious cycle. This is a report on a morbid obesity 42 year-old man with the MS and serum testosterone of 5.0 nmol/L (N: 12.0-33.0), who was resistant to treatment with diet and exercise. He was treated with testosterone undecanoate for 16 months.


METHODS
Anthropological and laboratory variables were measured before and during testosterone administration. Also the Aging Male Symptom Scale (AMS), the International Index of Erectile Function (IIEF) and Beck's Depression Inventory were assessed.


RESULTS
After 16 months, there was a weight loss of 50 kg and a decrease in waist circumference of 36.5 cm. Blood pressure normalized and laboratory variables returned to the normal range. The patient did not meet the criteria for the MS anymore. There were improvements on the AMS, the IIEF and Beck's Depression Inventory.


CONCLUSIONS
Normalizing testosterone in men with morbid obesity in combination with diet and exercise, with the MS and low testosterone levels, may rescue them from the MS, improving their mood and their stamina to follow a diet and to exercise.
Tishova
Yuliya
Y
Department of Andrology and Urology, Research Center for Endocrinology, Moscow, Russia. yulya_tishova@mail.rur
Kalinchenko
Svetlana Y
SY
D000328:Adult; D000728:Androgens / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D009767:Obesity, Morbid / Q000188:drug therapy*; D013739:Testosterone / Q000031:analogs & derivatives* / Q000172:deficiency* / Q000627:therapeutic use; D055105:Waist Circumference / Q000187:drug effects; D015431:Weight Loss / Q000187:drug effects
D000728:Androgens; D013739:Testosterone; C010792:testosterone undecanoate