[Influence of serum IGF-I and testosterone on lipid and glycemic profile in acromegalic men].
OBJECTIVE
To evaluate the influence of IGF-I and testosterone on the lipid profile and glycemia in acromegalic men.


METHODS
Fifteen acromegalic men were studied.


RESULTS
The hypogonadic patients presented lower HDL-c and higher tryglicerides, LDL-c, glycemia, GH and IGF-I. Serum IGF-I was inversely correlated with HDL-c (r = - 0.57, p = 0.04) and directly with TG (r = 0.62, p = 0.01) and glycemia (r = 0.66, p = 0.008), whereas serum testosterone correlated directly with HDL-c (r = 0.52, p = 0.05) and inversely with TG (r = - 0.57, p = 0.02), LDL-c (r = - 0.53, p = 0.04) and fasting blood glucose (r = - 0.54, p = 0.03). IGF-I and testosterone were inversely correlated (r = - 0.585, p = 0.028).


CONCLUSIONS
These results suggest that the most important intervention in reducing cardiovascular risk in these patients is to control the activity of the disease.
Figueiredo
Patrícia R L
PR
Serviço de Endocrinologia e Diabetes, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, CE, Brasil.
Martins
Manoel R A
MR
Montenegro
Renan M
RM
Albano
Mônica F
MF
Montenegro
Renan M
RM
D000172:Acromegaly / Q000097:blood*; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000096:biosynthesis*; D016022:Case-Control Studies; D006801:Humans; D007006:Hypogonadism / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008055:Lipids / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D013739:Testosterone / Q000097:blood*
D001786:Blood Glucose; D008055:Lipids; D013739:Testosterone; D007334:Insulin-Like Growth Factor I