title: Vertebroplasty and kyphoplasty - inefficient treatments for degenerative spine disease.
abstract: Osteoporotic vertebral fractures and pathological vertebral lesions are frequent clinical situations causing severe back pain. The pharmacological treatment of the underlying disease and the analgetic treatment of the associated back pain usually do not rid the patient's back pain completely and are insufficient to prevent the fracture-weakened vertebral body from further fracturing with long term consequences for the biomechanical competence of the entire spine. In the last 10 years the minimal invasive treatment options vertebroplasty (VP) and balloon kyphoplasty (BK) have spread quickly because these procedures appeared to be promising treatments to stop the fracture and vertebral lesion associated back pain and to internally stabilize a fractured vertebral body. Numerous published reports on VP and BK appeared to support the notion of an immediate and lasting pain reduction after VP and BK in additon to a prevention of further fracturing of the treated vertebrae. The first three randomized controlled and partly blinded trials have been published this year. Two of these trials demonstrate that VP does not result in a better pain control than a sham operation whereas BK was shown to reduce back pain due to verterbal fractures for at least 12 months. Considering that more than 1.5 million people world-wide have been treated with VP and BK until now this work discusses the recent trials and suggests clinical and academic consequences on the basis of the most recent evidence.
authors.forename: C
authors.initials: C
authors.lastname: Kasperk
authors.forename: P J
authors.initials: PJ
authors.lastname: Meeder
authors.forename: G
authors.initials: G
authors.lastname: Nöldge
authors.forename: B
authors.initials: B
authors.lastname: Wiedenhöfer
authors.forename: R
authors.initials: R
authors.lastname: Ewerbeck
authors.forename: H
authors.initials: H
authors.lastname: Bardenheuer
authors.forename: I
authors.initials: I
authors.lastname: Grafe
authors.forename: F-X
authors.initials: FX
authors.lastname: Huber
authors.forename: P
authors.initials: P
authors.lastname: Nawroth
mesh_terms: D001847:Bone Diseases / Q000150:complications / Q000601:surgery*; D005598:Fractures, Spontaneous / Q000209:etiology / Q000601:surgery*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D016103:Spinal Fractures / Q000209:etiology / Q000601:surgery*; D013131:Spine / Q000601:surgery; D016896:Treatment Outcome; D054854:Vertebroplasty