Roles of gastrointestinal and adipose tissue peptides in childhood obesity and changes after weight loss due to lifestyle intervention.
Childhood obesity is a global epidemic and associated with an increased risk of hypertension, diabetes mellitus, and coronary heart disease, in addition to psychological disorders. Interventions such as bariatric surgery are highly invasive and lifestyle modifications are often unsuccessful because of disturbed perceptions of satiety. New signaling peptides discovered in recent years that are produced in peripheral tissues such as the gut, adipose tissue, and pancreas communicate with brain centers of energy homeostasis, such as the hypothalamus and hindbrain. This review discusses the major known gut- and adipose tissue-derived hormones involved in the regulation of food intake and energy homeostasis and their serum levels in childhood obesity before and after weight loss as well as their relationship to consequences of obesity. Since most of the changes of gastrointestinal hormones and adipokines normalize in weight loss, pharmacological interventions based on these hormones will likely not solve the obesity epidemic in childhood. However, a better understanding of the pathways of body weight- and food intake-regulating gut- and adipose tissue-derived hormones will help to find new strategies to treat obesity and its consequences.
Roth
Christian L
CL
Division of Endocrinology, Seattle Children's Hospital Research Institute, 1900 Ninth Ave, Seattle, WA 98101, USA. christian.roth@seattlechildrens.org
Reinehr
Thomas
T
D054392:Adipokines / Q000097:blood* / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism*; D002648:Child; D002766:Cholecystokinin / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000201:enzymology* / Q000453:epidemiology; D004151:Dipeptides / Q000378:metabolism; D004765:Enteropeptidase / Q000097:blood* / Q000378:metabolism; D015444:Exercise; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D015438:Health Behavior; D006293:Health Promotion; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D008019:Life Style; D009765:Obesity / Q000097:blood / Q000453:epidemiology / Q000378:metabolism* / Q000517:prevention & control; D053772:Oxyntomodulin / Q000378:metabolism; D010191:Pancreatic Polypeptide / Q000378:metabolism; D012249:Rhombencephalon / Q000378:metabolism; D015431:Weight Loss
D054392:Adipokines; D004151:Dipeptides; D053772:Oxyntomodulin; C042696:tyrosyltyrosine; D010191:Pancreatic Polypeptide; D052216:Glucagon-Like Peptide 1; D002766:Cholecystokinin; D004765:Enteropeptidase