title: Oral Candida flora in a group of Jordanian patients with beta-thalassemia major.
abstract: OBJECTIVE
  Thalassemic patients present with multiple immune abnormalities that may predispose them to oral Candida, however this has not been investigated. The aim of this study was to assess oral candidal colonization in a group of patients with beta-thalassemia major both qualitatively and quantitatively.
  
  
  METHODS
  The oral mycologic flora of 50 beta-thalassemia major patients and 50 age- and sex-matched control subjects was assessed using the concentrated oral rinse technique. Candida species were identified using the germ tube test and the Vitek yeast identification system.
  
  
  RESULTS
  Oral Candida was isolated from 37 patients (74%) and 28 healthy subjects (56%; P = .04). The mean candidal count was significantly higher in thalassemic patients compared with the healthy group (P < .05) and in patients who had surgical splenectomy compared with nonsplenectomized patients (P = .04).
  
  
  CONCLUSIONS
  Oral Candida colonization and candidal counts are significantly higher in beta-thalassemia major patients than in healthy subjects. Surgical splenectomy may increase the quantity of colonizing oral candidal organisms in thalassemic patients.
authors.affiliation: Department of Oral Medicine and Surgery, Faculty of Dentistry, Jordan University of Science and Technology, Irbid, Jordan. hazza@just.edu.jo
authors.forename: A M
authors.initials: AM
authors.lastname: Hazza'a
authors.forename: Azmi M G
authors.initials: AM
authors.lastname: Darwazeh
authors.forename: Omar S M
authors.initials: OS
authors.lastname: Museedi
mesh_terms: D000293:Adolescent; D002175:Candida / Q000302:isolation & purification*; D002353:Carrier State; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D015169:Colony Count, Microbial; D005260:Female; D006801:Humans; D008297:Male; D009055:Mouth / Q000382:microbiology*; D013156:Splenectomy; D018709:Statistics, Nonparametric; D017086:beta-Thalassemia / Q000276:immunology / Q000382:microbiology*