title: Selective generation of quaternary all-carbon-centres through Heck-cyclisations: synthesis of mesembrane.
abstract: Described is an observation that the intramolecular Heck reaction of a trisubstituted alkene proceeds with high regioselectivity and leads to the preferential formation of a quaternary all-carbon-centre. This observation was subsequently applied in a short synthesis of (+/-)-mesembrane.
authors.affiliation: Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Dublin 4, Ireland.
authors.forename: Johannes E M N
authors.initials: JE
authors.lastname: Klein
authors.forename: Kimberly
authors.initials: K
authors.lastname: Geoghegan
authors.forename: Nicolas
authors.initials: N
authors.lastname: Méral
authors.forename: Paul
authors.initials: P
authors.lastname: Evans