Wittig olefination between phosphine, aldehyde, and allylic carbonate: a general method for stereoselective synthesis of trisubstituted 1,3-dienes with highly variable substituents.
A clean and salt-free Wittig olefination between phosphines, aldehydes, and allylic carbonates is described. It represents a general method for convenient and efficient synthesis of 1,2,4-trisubstituted 1,3-dienes from readily available starting materials. This method exhibits high synthetic efficiency, high stereoselectivity, and high variability of substituent.
Zhou
Rong
R
The State Key Laboratory of Elemento-Organic Chemistry and Department of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, PR China.
Wang
Chunzhang
C
Song
Haibin
H
He
Zhengjie
Z