title: [Serum androgen concentrations and bone mineral density in postmenopausal ovariectomized and non-ovariectomized women].
abstract: OBJECTIVE
  Compare levels of androgens and bone mineral density (BMD) of ovariectomized (OVX) and non-ovariectomized (NOVX) postmenopausal women. Forty women, 20 OVX and 20 NOVX, (53.9 +/- 4 years) were selected.
  
  
  METHODS
  Total testosterone (TT), free testosterone (FT), androstenedione (AN), dehidroepiandrostenedione (DHEA) and its sulfate (DHEA-S) were measured. BMD was measured in 14 OVX and 16 NOVX.
  
  
  RESULTS
  No differences between groups with regard to age, body mass index (BMI) and time since menopause were found. Mean levels of TT and FT were two-fold higher in NOVX group (60.91 versus 30.17 ng/dL, p = 0.0001; 1.00 versus 0.48 pg/mL, p = 0.003). BMD was not different between groups. Inverse correlations were found between BMI and TT (r = -0.3; p = 0.05); time since menopause and AN (r = -0.35; p = 0.02) and time since menopause and DHEA (r = -0.3; p = 0.01).
  
  
  CONCLUSIONS
  Bilateral ovariectomy leads to a more severe androgen deficiency than natural menopause in postmenopausal women and did not compromise bone mass.
authors.affiliation: Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil. jkulak@ufpr.br
authors.forename: Jaime
authors.initials: J
authors.lastname: Kulak
authors.forename: Almir Antônio
authors.initials: AA
authors.lastname: Urbanetz
authors.forename: Carolina Aguiar Moreira
authors.initials: CA
authors.lastname: Kulak
authors.forename: Victória Zegbi Cochenski
authors.initials: VZ
authors.lastname: Borba
authors.forename: César Luiz
authors.initials: CL
authors.lastname: Boguszewski
mesh_terms: D000728:Androgens / Q000097:blood*; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010052:Ovariectomy; D017698:Postmenopause / Q000097:blood / Q000502:physiology*; D018709:Statistics, Nonparametric
chemical_list: D000728:Androgens