[New insights into obesity].
Central to obesity is an energy imbalance due to increased calorie intake and/or decreased energy expenditure, as well as a genetic or non genetic biological predisposition. New advances in obesity research point to a role of primary changes in fat storage capacity. Modifications of the cellular composition and structure of adipose tissue, characterized by inflammation and fibrosis, can lead to an "organ disease" that is partially irreversible, thus explaining long-term treatment resistance. This organ disease may lead to local and systemic disorders. A possible role of the gut flora is one especially interesting line of research.
Basdevant
Arnaud
A
Pôle d'Endocrinologie de la Pitié Salpêtrière, AP-HP, 47 bld de l'Hôpital, 75651 Paris cedex 13. arnaud.basdevant@psl.aphp.fr
Ciangura
Cécile
C
D000273:Adipose Tissue / Q000503:physiopathology; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D009765:Obesity / Q000503:physiopathology*