title: Advanced cancer with situs inversus totalis associated with KIF3 complex deficiency: report of two cases.
abstract: Situs inversus totalis (SIT) is a relatively rare congenital anomaly, occurring at an incidence of 1 in 10 000-50 000 live births. Although there are some case reports of SIT with the presence of cancer, there are few reports on the relationship between SIT and cancer. However, the recent phylogenetic investigations of this condition suggest that this may be linked to the development and progression of cancer on the molecular level. The key elements are one of the intracellular motor proteins, the KIF3 complex, and the cell-adhesion factors N-cadherin and beta-catenin. We herein present the cases of advanced gastric cancer and lung cancer with SIT, and review the relationship between SIT and the development and progression of cancer.
authors.affiliation: Department of Surgery, Tottori Prefectural Central Hospital, 730 Ezu, Tottori, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Haruki
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maeta
authors.forename: Sei-ichi
authors.initials: S
authors.lastname: Nakamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Sawata
authors.forename: Tetsu
authors.initials: T
authors.lastname: Shimizu
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kishi
authors.forename: Shigeto
authors.initials: S
authors.lastname: Miyasaka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Maeta
authors.forename: Keisuke
authors.initials: K
authors.lastname: Morimoto
authors.forename: Iwao
authors.initials: I
authors.lastname: Taniguchi
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016547:Kinesins / Q000172:deficiency*; D008175:Lung Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008297:Male; D012857:Situs Inversus / Q000150:complications* / Q000378:metabolism; D013274:Stomach Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D016896:Treatment Outcome; D051176:beta Catenin / Q000378:metabolism
chemical_list: C495270:CTNNB1 protein, human; D015820:Cadherins; D051176:beta Catenin; D016547:Kinesins