title: [The GATA family in reproduction].
abstract: The GATA family proteins are a group of zinc finger transcription factors that are expressed in human and mammalian animals and play an important role in mammalian organ morphogenesis, cell proliferation and sex differentiation. GATA-4 and GATA-6 have been identified in the ovaries and testes of humans, mice, pigs and chickens. GATA-4 contributes to fetal male gonadal development by regulating the genes that mediate Müllerian duct regression and the onset of testosterone production. GATA-4 and GATA-6 are localized in and regulate the function of the ovarian and testicular somatic cells of fetal mice, especially granulosa cells, thecal cells, Sertoli cells and Leydig cells. GATA-4 is also present in the germ cells of fetal and prepubertal mice.
authors.affiliation: Department of Parasitology, West China School of Preclinical and Forensic Medicine, Sichuan University, Cheng-du, Sichuan 610041, China.
authors.forename: Cai-xia
authors.initials: CX
authors.lastname: Jing
authors.forename: Jia-zhou
authors.initials: JZ
authors.lastname: Yang
authors.forename: Qing-yan
authors.initials: QY
authors.lastname: Ai
authors.forename: Nai-zhou
authors.initials: NZ
authors.lastname: Miao
authors.forename: Yu-feng
authors.initials: YF
authors.lastname: Zhao
authors.forename: Yan-mei
authors.initials: YM
authors.lastname: Wang
mesh_terms: D000818:Animals; D002645:Chickens; D005260:Female; D050991:GATA4 Transcription Factor / Q000378:metabolism*; D050993:GATA6 Transcription Factor / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D010053:Ovary / Q000196:embryology; D012098:Reproduction; D013552:Swine; D013737:Testis / Q000196:embryology; D014157:Transcription Factors / Q000145:classification
chemical_list: D050991:GATA4 Transcription Factor; D050993:GATA6 Transcription Factor; D014157:Transcription Factors