Antibacterial constituents from the roots of Erythrina herbacea against methicillin-resistant Staphylococcus aureus.
Two new compounds, erybacin A (1) and erybacin B (2), together with 10 known compounds (3- 12), were isolated from the roots of Erythrina herbacea. Their structures were established on the basis of spectroscopic analyses. Erybacin A is a rare, naturally occurring 1-hydroxy-1,3-diphenylpropan-2-one derivative. The isolated compounds were evaluated for their antibacterial activity against 13 strains of methicillin-resistant Staphylococcus aureus (MRSA). The new compound 2 showed a potent bactericidal activity against MRSA.
Tanaka
Hitoshi
H
Faculty of Pharmacy, Meijo University, Yagoto, Tempaku-ku, Nagoya, Japan. hitoshi@ccmfs.meijo-u.ac.jp
Sudo
Masaru
M
Kawamura
Tomoko
T
Sato
Masaru
M
Yamaguchi
Ryozo
R
Fukai
Toshio
T
Sakai
Eiji
E
Tanaka
Nobuyuki
N
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004895:Erythrina / Q000737:chemistry*; D016106:Methicillin Resistance / Q000187:drug effects*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D010936:Plant Extracts; D012118:Resorcinols; C554607:erybacin A; C554608:erybacin B