[TSH-secreting pituitary tumors: two case reports and literature review].
BACKGROUND
TSH-secreting pituitary adenomas are rare pituitary functioning tumors accounting for less than 2% of the pituitary adenomas. The clinical feature consists of thyrotoxicosis occasionally associated to tumoral symptoms due to mass effect. The biochemical feature consists of elevated thyroid hormones levels and normal or high TSH concentrations. This disease is often wrongly diagnosed as Grave's disease, and the ablative therapy is frequently conducted prior to the diagnosis.


OBJECTIVE
To report two cases followed in the Neuroendocrine Unit of Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo and to review the literature aiming at the management of this affection.


CONCLUSIONS
In the presence of elevated thyroid hormone levels associated with inappropriate normal or increased TSH levels, the possibility of a TSH-secreting pituitary adenoma should be considered for the proper medical treatment.
Duarte
Felipe Henning Gaia
FH
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil. felipe_gaia1@hotmail.com
Jallad
Raquel Soares
RS
Salgado
Luiz Roberto
LR
Bronstein
Marcello Delano
MD
D000236:Adenoma / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009384:Paraneoplastic Endocrine Syndromes / Q000175:diagnosis; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology*; D013971:Thyrotoxicosis / Q000473:pathology*; D052684:Thyrotrophs / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult