title: The cytotoxic properties of natural coumarins isolated from roots of Ferulago campestris (Apiaceae) and of synthetic ester derivatives of aegelinol.
abstract: Grandivittin (1), agasyllin (2), aegelinol benzoate (3) and felamidin (20), four natural coumarins isolated from Ferulago campestris, and several synthetic ester derivatives of aegelinol (4) were tested against four tumor cell lines. Some of them were shown to be marginally cytotoxic against the A549 lung cancer cell line.
authors.affiliation: Dipartimento Chimica Organica "E. Paternò ", Università di Palermo, Viale delle Scienze, Parco d'Orleasn II, 90128 Palermo, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Rosselli
authors.forename: Antonella Maria
authors.initials: AM
authors.lastname: Maggio
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Faraone
authors.forename: Vivienne
authors.initials: V
authors.lastname: Spadaro
authors.forename: Susan L
authors.initials: SL
authors.lastname: Morris-Natschke
authors.forename: Kenneth F
authors.initials: KF
authors.lastname: Bastow
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bruno
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; C547463:aegelinol