The cytotoxic properties of natural coumarins isolated from roots of Ferulago campestris (Apiaceae) and of synthetic ester derivatives of aegelinol.
Grandivittin (1), agasyllin (2), aegelinol benzoate (3) and felamidin (20), four natural coumarins isolated from Ferulago campestris, and several synthetic ester derivatives of aegelinol (4) were tested against four tumor cell lines. Some of them were shown to be marginally cytotoxic against the A549 lung cancer cell line.
Rosselli
Sergio
S
Dipartimento Chimica Organica "E. Paternò ", Università di Palermo, Viale delle Scienze, Parco d'Orleasn II, 90128 Palermo, Italy.
Maggio
Antonella Maria
AM
Faraone
Nicoletta
N
Spadaro
Vivienne
V
Morris-Natschke
Susan L
SL
Bastow
Kenneth F
KF
Lee
Kuo-Hsiung
KH
Bruno
Maurizio
M
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; C547463:aegelinol