title: Neurological complications following adult lung transplantation.
abstract: The full spectrum of neurologic complications and their impact on survival in lung recipients has not been reported. A retrospective cohort review of the Mayo Clinic Lung Transplant Registry (1988-2008) was performed to determine the range of neurologic complications in a cohort of adult lung recipients. Cox regression models were used to assess risk factors for neurological complications and death posttransplant. One hundred and twenty lung transplant recipients (53% women, median age at transplantation 53 years, range 21-73, median survival 4.8 years) were identified, of whom 95 had a neurological complication posttransplantation (median time to complication 0.8 years). Neurological complications were severe in 46 patients (requiring hospitalization or urgent care and evaluation) and were most often perioperative stroke or encephalopathy. Age predicted neurological complications of any type, whereas lung allocation score, bilateral lung transplantation, sex, underlying lung disease, elevated hemoglobin A1C, renal insufficiency and smoking history did not. Neurological complications of any severity (HR 4.3, 95% CI 2.2-8.6, p < 0.001) and high severity (HR 7.2, 95% CI 3.5-14.6, p < 0.001) were associated with increased risk of death. Neurological complications are common after lung transplantation, affecting 92% of recipients within 10 years. Severe neurologic complications are also common, affecting 53% of recipients within 10 years.
authors.affiliation: Department of Neurology.
authors.forename: F J
authors.initials: FJ
authors.lastname: Mateen
authors.affiliation: Division of Biomedical Statistics and Informatics Mayo Clinic, Rochester, MN.
authors.forename: R A
authors.initials: RA
authors.lastname: Dierkhising
authors.affiliation: Department of Neurology.
authors.forename: A A
authors.initials: AA
authors.lastname: Rabinstein
authors.affiliation: Department of Neurology, Center of Infection and Immunity Amsterdam (CINIMA) Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Van De Beek
authors.affiliation: Department of Neurology.
authors.forename: E F M
authors.initials: EFM
authors.lastname: Wijdicks
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery*; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies