title: Sesquiterpenoids from the formosan soft coral Sinularia leptoclados.
abstract: Chemical investigation of the soft coral Sinularia leptoclados has afforded three new sesquiterpenoids, leptocladols A (1), B (2), and 1-epi-chabrolidione A (3). The relative structures of 1-3 were determined on the basis of extensive spectroscopic analysis. The relative configuration of 1 was further confirmed by a single-crystal X-ray diffraction analysis.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Chiang
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wen
authors.forename: Chang-Feng
authors.initials: CF
authors.lastname: Dai
authors.forename: Chi-Hsin
authors.initials: CH
authors.lastname: Hsu
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008958:Models, Molecular; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D014961:X-Ray Diffraction
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D008070:Lipopolysaccharides; D012717:Sesquiterpenes