Binding bacteria to highly branched poly(N-isopropyl acrylamide) modified with vancomycin induces the coil-to-globule transition.
Binding of highly branched poly(N-isopropylacrylamide) with vancomycin end groups to Staphylococcus aureus induced a coil-to-globule phase transition. The polymers aggregated this gram-positive bacteria (but not gram-negative bacteria) over a wide range of temperatures, but cooling to 24-26 degrees C progressed the polymer-bound bacteria through a globule-to-coil phase transition, after which the bacteria were released.
Shepherd
Joanna
J
School of Clinical Dentistry, University of Sheffield, Sheffield S10 2TA, UK.
Sarker
Prodip
P
Swindells
Kathryn
K
Douglas
Ian
I
MacNeil
Sheila
S
Swanson
Linda
L
Rimmer
Stephen
S
D000178:Acrylamides / Q000737:chemistry* / Q000378:metabolism*; D000180:Acrylic Resins; D001419:Bacteria / Q000378:metabolism*; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism*; D013050:Spectrometry, Fluorescence; D013696:Temperature; D014640:Vancomycin / Q000737:chemistry*
D000178:Acrylamides; D000180:Acrylic Resins; D011108:Polymers; C052970:poly-N-isopropylacrylamide; D014640:Vancomycin