title: Anti-virus effect of traditional Chinese medicine Yi-Fu-Qing granule on acute respiratory tract infections.
abstract: Yi-Fu-Qing granule is a traditional Chinese medicine for the treatment of acute respiratory tract infections. The present study sought to investigate the anti-virus effects of Yi-Fu-Qing granule on acute respiratory infections with respiratory syncytial virus (RSV) and human adenoviruses type 3 (Ad3). The cytotoxicity of Yi-Fu-Qing granule was evaluated by the neutral red assay on HeLa cells. The antiviral effect of Yi-Fu-Qing granule was tested by observing the cytopathogenic effect (CPE) with a compound mixture of Isatis leaf as the positive control drug. The results indicated that the highest non-toxicity concentration of Yi-Fu-Qing granule on Hela cells was 1:100. The CPE reduction assay showed that Yi-Fu-Qing granule inhibited RSV and Ad3 replication at a concentration of 1:100. Thus, Yi-Fu-Qing granule may have a significant antivirus effect on acute respiratory tract infections with RSV and Ad3 infections and this could prove useful for further antivirus research on acute respiratory tract infections.
authors.affiliation: Department of Traditional Chinese Medicine, Provincial Hospital Affiliated to Shandong University, Ji'nan, Shandong, China. sdslyy999@163.com
authors.forename: Anyuan
authors.initials: A
authors.lastname: Li
authors.forename: Yanying
authors.initials: Y
authors.lastname: Xie
authors.forename: Fanghua
authors.initials: F
authors.lastname: Qi
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Shulan
authors.initials: S
authors.lastname: Xu
authors.forename: Lin
authors.initials: L
authors.lastname: Zhao
mesh_terms: D000704:Analysis of Variance; D000998:Antiviral Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D031219:Isatis / Q000737:chemistry; D009499:Neutral Red; D012136:Respiratory Syncytial Viruses / Q000187:drug effects*; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D023382:Toxicity Tests, Acute; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D009499:Neutral Red