title: Virginols A-C, three new withanolides from Physalis virginiana.
abstract: Virginols A-C are three new withanolides containing an epoxylactol at the side chain. They were isolated from the aerial parts of Physalis virginiana Miller. Structures of these compounds were determined by analyses of their spectroscopic data, including 1D and 2D NMR. The structure of virginol A was confirmed by X-ray diffraction analysis. The anti-inflammatory activity of virginols was evaluated in the TPA-induced ear mouse edema model.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, D.F., Mexico. emmaldon@servidor.unam.mx <emmaldon@servidor.unam.mx>
authors.forename: Emma
authors.initials: E
authors.lastname: Maldonado
authors.forename: Sonia
authors.initials: S
authors.lastname: Amador
authors.forename: Mahinda
authors.initials: M
authors.lastname: Martínez
authors.forename: Ana L
authors.initials: AL
authors.lastname: Pérez-Castorena
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D032321:Physalis / Q000737:chemistry*; D054358:Withanolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D054358:Withanolides; C550567:virginol A; C550568:virginol B; C550566:virginol C