title: Do microsatellites reflect genome-wide genetic diversity in natural populations? A comment on Väli et al. (2008).
abstract: A recent study by Väli et al. (2008) highlights that microsatellites will often provide a poor prediction of the genome-wide nucleotide diversity of wild populations, but does not fully explain why. To clarify and stress the importance of identity disequilibrium and marker variability for correlations between multilocus heterozygosity and genome-wide genetic variability, we performed a simple simulation with different types of markers, corresponding to microsatellites and SNPs, in populations with different inbreeding history. The importance of identity disequilibrium was apparent for both markers and there was a clear impact of marker variability.
authors.affiliation: Department of Animal Ecology, Ecology Building, Lund University, S-223 62 Lund, Sweden. marcus.ljungqvist@zooekol.lu.se
authors.forename: Marcus
authors.initials: M
authors.lastname: Ljungqvist
authors.forename: Mikael
authors.initials: M
authors.lastname: Akesson
authors.forename: Bengt
authors.initials: B
authors.lastname: Hansson
mesh_terms: D000818:Animals; D003198:Computer Simulation; D003247:Conservation of Natural Resources; D014644:Genetic Variation; D005828:Genetics, Population; D006579:Heterozygote; D007178:Inbreeding; D018895:Microsatellite Repeats; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide