Current review of small molecule Ret kinase inhibitors.
Aberrant Ret kinase activity has been implicated in multiple carcinomas and disorders. Many strategies have been implemented to identify Ret kinase inhibitors. This review details current efforts to discover novel small molecule Ret kinase inhibitors. Furthermore, we compile a comprehensive list of Ret kinase inhibitors and describe clinical results of advanced assets with Ret inhibitory activity.
Zuercher
W J
WJ
GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA.
Turunen
B J
BJ
Lackey
K E
KE
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D006801:Humans; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D051096:Proto-Oncogene Proteins c-ret / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D051096:Proto-Oncogene Proteins c-ret