Palladium(II)-catalyzed oxidative C-H/C-H cross-coupling of heteroarenes.
An efficient methodology for the synthesis of unsymmetrical biheteroaryl molecules has been developed via Pd(II)-catalyzed oxidative C-H/C-H cross-coupling of heteroarenes. An inversion in reactivity and selectivity has been achieved successfully to perform the desired heterocoupling. This process allows the heterocoupling of not only electron-rich N-containing heteroarenes (e.g., xanthines, azoles, and indolizines) but also electron-poor pyridine N-oxides with various thiophenes or furans.
Xi
Peihua
P
Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China.
Yang
Fan
F
Qin
Song
S
Zhao
Dongbing
D
Lan
Jingbo
J
Gao
Ge
G
Hu
Changwei
C
You
Jingsong
J
D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D004583:Electrons; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
D006571:Heterocyclic Compounds; D010165:Palladium; D002244:Carbon; D006859:Hydrogen