title: Outcome of aortic valve replacement with bioprostheses in the elderly.
abstract: OBJECTIVE
  Today, the elderly population continues to increase worldwide, and rates of aortic stenosis (AS) climb with age. Since aortic valve replacement (AVR) is the current treatment for elderly patients with symptomatic AS, the number of patients undergoing AVR is expected to grow.
  
  
  METHODS
  Among patients operated on at Helsinki University Hospital between 1992 and 1997, a cohort (n = 145) was followed after AVR with a bioprosthesis. The patients were allocated to three groups, based on their age at the time of surgery: > or = 80 years (n = 30), < 80 to > or = 70 years (n = 94), and < or = 70 years (n = 21). All data relating to preoperative risk factors were collected. A control examination, which included echocardiography, was performed at least five years after surgery, and the follow up was continued until July 2006. The number of deaths and causes of death, as well as valve-related complications, were noted.
  
  
  RESULTS
  The 30-day mortality rates were 3.3% in the oldest (> or = 80-year) group, 6.4% in the middle (< 80 to > or = 70-year) group, and zero in the youngest (< or = 70-year) group. The mean age at death was 88 and 81 years in the oldest and middle groups, respectively. In the oldest and youngest groups, there were no reoperations, but five valve-related reoperations were performed during follow up in the middle group. At the control visit, the left ventricular ejection fraction was > 60% in all groups. In the oldest and middle groups the aortic valve gradient was lower than the preoperative level, while the left ventricular diameters and wall dimensions were smaller (p < 0.05). Valve calcification was observed in one patient in the youngest group.
  
  
  CONCLUSIONS
  Elderly patients who had undergone AVR with a bioprosthesis had a good outcome after more than 10 years of follow up, with an improved cardiac function being preserved for at least seven years after surgery. Despite a severely impaired preoperative aortic valve function, octogenarians especially had a good life expectancy, possibly due to their low comorbidity rates. Hence, AVR with a bioprosthesis proved to be an excellent treatment in this patient group.
authors.affiliation: Department of Anesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland. raili.suojaranta-ylinen@hus.fi
authors.forename: Raili T
authors.initials: RT
authors.lastname: Suojaranta-Ylinen
authors.forename: Sari
authors.initials: S
authors.lastname: Soisalon-Soininen
authors.forename: Maija
authors.initials: M
authors.lastname: Kaartinen
authors.forename: Paula K
authors.initials: PK
authors.lastname: Maasilta
authors.forename: Tiina L
authors.initials: TL
authors.lastname: Vainikka
authors.forename: Antti E
authors.initials: AE
authors.lastname: Vento
authors.forename: Ulla-Stina
authors.initials: US
authors.lastname: Salminen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000401:mortality / Q000601:surgery*; D001705:Bioprosthesis; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome