Enzymatically degradable heparin-polyethylene glycol gels with controlled mechanical properties.
A new class of biodegradable materials was prepared by combining polyethylene glycol, heparin, and a matrix metalloproteinase-cleavable peptide sequence into a well-defined hydrogel network which mimics native extracellular matrices in its ability to provide mechanical support and chemical signals as well as elicit a dynamic reciprocal response.
Tsurkan
Mikhail V
MV
Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials Dresden Hohe Str. 6, 01069 Dresden, Germany.
Levental
Kandice R
KR
Freudenberg
Uwe
U
Werner
Carsten
C
D000595:Amino Acid Sequence; D006493:Heparin / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000737:chemistry; D020782:Matrix Metalloproteinases / Q000378:metabolism; D010455:Peptides / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D010455:Peptides; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D006493:Heparin; D020782:Matrix Metalloproteinases