Androgen deprivation and stem cell markers in prostate cancers.
In our previous studies using human LNCaP xenografts and TRAMP (transgenic adenocarcinoma of mouse prostate) mice, androgen deprivation therapy (ADT) resulted in a temporary cessation of prostate cancer (PCa) growth, but then tumors grew faster with more malignant behaviour. To understand whether cancer stem cells might play a role in PCa progression in these animal models, we investigated the expressions of stem cell-related markers in tumors at different time points after ADT. In both animal models, enhanced expressions of stem cell markers were observed in tumors of castrated mice, as compared to non-castrated controls. This increased cell population that expressed stem cell markers is designated as stem-like cells (SLC) in this article. We also observed that the SLC peaked at relatively early time points after ADT, before tumors resumed their growth. These results suggest that the SLC population may play a role in tumor re-growth and disease progression, and that targeting the SLC at their peak-expression time point may prevent tumor recurrence following ADT.
Tang
Yao
Y
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. ytang@som.umaryland.edu
Hamburger
Anne W
AW
Wang
Linbo
L
Khan
Mohammad Afnan
MA
Hussain
Arif
A
D000230:Adenocarcinoma / Q000473:pathology; D000728:Androgens / Q000378:metabolism*; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D016513:Mice, SCID; D008822:Mice, Transgenic; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009368:Neoplasm Transplantation; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D013234:Stem Cells / Q000378:metabolism*; D013997:Time Factors
D000728:Androgens; D014408:Biomarkers, Tumor