title: Effects of general anesthesia on plasma colloid oncotic pressure in dogs.
abstract: OBJECTIVE
  To determine the magnitude of the change in colloid oncotic pressure (COP) associated with general anesthesia in dogs undergoing a variety of elective procedures.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  50 client-owned dogs.
  
  
  METHODS
  For each dog, preanesthetic and postanesthetic PCV, plasma total solids (TS) concentration, and COP were determined. The procedures requiring anesthesia, volume of crystalloid fluids administered IV, duration of anesthesia, age, weight, and sex were recorded.
  
  
  RESULTS
  Postanesthetic PCV (mean +/- SD, 41.8 +/- 5.4%), TS concentration (6.3 +/- 0.8 g/dL), and COP (19.4 +/- 3.6 mm Hg) were significantly decreased, compared with preanesthetic values (48.8 +/- 5.9%, 7.2 +/- 0.7 g/dL, and 24.4 +/- 4.2 mm Hg, respectively). None of the variables tested could be used to reliably predict changes in COP.
  
  
  CONCLUSIONS
  Results suggested that COP in healthy dogs may decrease by 5 mm Hg on average after general anesthesia and that this decrease may not be reliably predicted by the volume of fluids administered IV during anesthesia or by the concurrent measured decrease in TS concentration.
authors.affiliation: Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
authors.forename: David I
authors.initials: DI
authors.lastname: Dismukes
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Thomovsky
authors.forename: F A
authors.initials: FA
authors.lastname: Mann
authors.forename: John R
authors.initials: JR
authors.lastname: Middleton
mesh_terms: D000768:Anesthesia, General / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000494:pharmacology; D018686:Anesthetics, Intravenous / Q000494:pharmacology; D000818:Animals; D001798:Blood Proteins / Q000502:physiology*; D003102:Colloids / Q000378:metabolism*; D000077324:Crystalloid Solutions; D004285:Dogs; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000494:pharmacology; D009997:Osmotic Pressure / Q000502:physiology*; D015532:Rehydration Solutions / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D001798:Blood Proteins; D003102:Colloids; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D015532:Rehydration Solutions