title: Quantification of the spatiotemporal microstructural organization of the human brain association, projection and commissural pathways across the lifespan using diffusion tensor tractography.
abstract: Using diffusion tensor tractography, we quantified the microstructural changes in the association, projection, and commissural compact white matter pathways of the human brain over the lifespan in a cohort of healthy right-handed children and adults aged 6-68 years. In both males and females, the diffusion tensor radial diffusivity of the bilateral arcuate fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, uncinate fasciculus, corticospinal, somatosensory tracts, and the corpus callosum followed a U-curve with advancing age; fractional anisotropy in the same pathways followed an inverted U-curve. Our study provides useful baseline data for the interpretation of data collected from patients.
authors.affiliation: Department of Diagnostic and Interventional Imaging, University of Texas Medical School at Houston-Medical School, Houston, TX 77030, USA. Khader.M.Hasan@uth.tmc.edu
authors.forename: Khader M
authors.initials: KM
authors.lastname: Hasan
authors.forename: Arash
authors.initials: A
authors.lastname: Kamali
authors.forename: Humaira
authors.initials: H
authors.lastname: Abid
authors.forename: Larry A
authors.initials: LA
authors.lastname: Kramer
authors.forename: Jack M
authors.initials: JM
authors.lastname: Fletcher
authors.forename: Linda
authors.initials: L
authors.lastname: Ewing-Cobbs
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000033:anatomy & histology*; D002648:Child; D015331:Cohort Studies; D003337:Corpus Callosum / Q000033:anatomy & histology* / Q000502:physiology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000502:physiology; D009434:Neural Pathways / Q000033:anatomy & histology; D012737:Sex Factors; D055815:Young Adult