Paraoxonase-1 in female infertility: a possible role against oxidative stress-induced inflammation.
In this observational, case-control study in infertile women, we observed elevated serum oxidative stress that was significantly correlated with an increase in serum paraoxonase-1 activity and without any evidence of a proinflammatory reaction. These results suggest a protective role of paraoxonase-1 against inflammation in this clinical setting.
Marsillach
Judit
J
Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Reus, Catalunya, Spain.
Checa
Miguel Angel
MA
Pedro-Botet
Juan
J
Carreras
Ramon
R
Joven
Jorge
J
Camps
Jordi
J
D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood* / Q000378:metabolism / Q000502:physiology*; D002097:C-Reactive Protein / Q000032:analysis / Q000378:metabolism; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood / Q000378:metabolism; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000209:etiology / Q000378:metabolism; D007249:Inflammation / Q000097:blood / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control*; D015850:Interleukin-6 / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000378:metabolism; D055815:Young Adult
C111835:CCL2 protein, human; D018932:Chemokine CCL2; C508600:IL6 protein, human; D015850:Interleukin-6; D008054:Lipid Peroxides; D002097:C-Reactive Protein; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human