Myeloma cells with asurophilic granules--an unusual morphological variant--case presentation.
We present the case of an 80-year-old man who was admitted for anemia, back pain and progressive weakness. After a workup of clinical and laboratory data, the final diagnosis was multiple myeloma. The bone marrow aspirate revealed 53% myeloma cells with peculiar and rare morphological features: numerous large asurophilic--bright red granules--mucopolizaccharides and immunoglobulins secreted and accumulated in the endoplasmic reticulum, typically known as Russel bodies.
Vlădăreanu
Ana Maria
AM
University of Medicine and Pharmacy Carol Davila, Clinic of Hematology Universitary Emergency Hospital, Bucharest.
Cîşleanu
Diana
D
Derveşteanu
Mihaela
M
Onisâi
Minodora
M
Bumbea
Horia
H
Radeşi
Sînziana
S
Begu
Mădălina
M
Cristina
Băluţă
B
D000369:Aged, 80 and over; D001854:Bone Marrow Cells / Q000473:pathology*; D003594:Cytoplasmic Granules / Q000473:pathology; D005598:Fractures, Spontaneous / Q000473:pathology; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009101:Multiple Myeloma / Q000000981:diagnostic imaging / Q000473:pathology*; D010950:Plasma Cells / Q000473:pathology*; D011859:Radiography; D016103:Spinal Fractures / Q000473:pathology