title: Novel antitumor acetamide, pyrrole, pyrrolopyrimidine, thiocyanate, hydrazone, pyrazole, isothiocyanate and thiophene derivatives containing a biologically active pyrazole moiety.
abstract: 4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)-benzenesulfonamide (sulfaphenazole) 1 was selected as strategic starting material for the synthesis of some novel acetamide 2, pyrrole 4, pyrrolo[2,3-d]pyrimidine 5, thiocyanate 6, hydrazone 7a,b pyrazole 8, isothiocyanate 9 and thiophene 12 derivatives to evaluate theantitumor activity. Compound 4 was more effective than the reference drug, doxorubicin (CAS 23214-92-8) as positive control.
authors.affiliation: Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Saleh I
authors.initials: SI
authors.lastname: Alqasoumi
authors.forename: Moustafa M
authors.initials: MM
authors.lastname: Ghorab
authors.forename: Zeinab H
authors.initials: ZH
authors.lastname: Ismail
authors.forename: Soad M
authors.initials: SM
authors.lastname: Abdel-Gawad
authors.forename: Mohamed S A
authors.initials: MS
authors.lastname: El-Gaby
authors.forename: Hala M
authors.initials: HM
authors.lastname: Aly
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
chemical_list: D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D011720:Pyrazoles