Prevalence and antimicrobial resistance of Campylobacter isolates in broilers from China.
The prevalence and antimicrobial resistance of Campylobacter spp. in broiler chickens were determined in Shandong Province, China. In total, 275 Campylobacter isolates were obtained from 767 broiler cecal samples, including 208 Campylobacter jejuni, 53 Campylobacter coli, and 14 unidentified Campylobacter isolates. Minimal inhibitory concentrations of 11 antimicrobial agents were determined using the agar dilution method recommended by CLSI. More than 98% of the tested Campylobacter isolates were resistant to quinolones (nalidixic acid, ciprofloxacin and enrofloxacin) and tetracyclines (tetracycline and doxycycline). The C. jejuni isolates also exhibited a high rate of resistance to phenicol antibiotics and a moderate rate of resistance to macrolides and gentamicin. On the contrary, the C. coli isolates showed a high-level resistance to macrolides and gentamicin and little resistance to phenicol antibiotics. The vast majority of the Campylobacter isolates were classified as multidrug resistant. These findings reveal a broad extent of antimicrobial resistance in Campylobacter isolates from poultry in China and underline the need for prudent use of antibiotics in poultry production to minimize the spread of antibiotic resistant Campylobacter.
Chen
Xia
X
National Reference Laboratory for Veterinary Drug Residue, Key Laboratory of Development and Evaluation of the Chemical and Herbal Drugs for Animal Use, Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People's Republic of China.
Naren
Gao-Wa
GW
Wu
Cong-Ming
CM
Wang
Yang
Y
Dai
Lei
L
Xia
Li-Ning
LN
Luo
Peng-Jie
PJ
Zhang
Qijing
Q
Shen
Jian-Zhong
JZ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002167:Campylobacter / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D002169:Campylobacter Infections / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary*; D017000:Campylobacter coli / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D016123:Campylobacter jejuni / Q000187:drug effects / Q000302:isolation & purification; D002645:Chickens; D002681:China / Q000453:epidemiology; D017931:DNA Primers; D004352:Drug Resistance, Microbial / Q000187:drug effects; D005784:Gene Amplification; D011201:Poultry Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D012335:RNA, Ribosomal / Q000235:genetics
D000900:Anti-Bacterial Agents; D017931:DNA Primers; D012335:RNA, Ribosomal