Virginols A-C, three new withanolides from Physalis virginiana.
Virginols A-C are three new withanolides containing an epoxylactol at the side chain. They were isolated from the aerial parts of Physalis virginiana Miller. Structures of these compounds were determined by analyses of their spectroscopic data, including 1D and 2D NMR. The structure of virginol A was confirmed by X-ray diffraction analysis. The anti-inflammatory activity of virginols was evaluated in the TPA-induced ear mouse edema model.
Maldonado
Emma
E
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, D.F., Mexico. emmaldon@servidor.unam.mx <emmaldon@servidor.unam.mx>
Amador
Sonia
S
Martínez
Mahinda
M
Pérez-Castorena
Ana L
AL
D000818:Animals; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D032321:Physalis / Q000737:chemistry*; D054358:Withanolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D054358:Withanolides; C550567:virginol A; C550568:virginol B; C550566:virginol C