title: Narrowband ultraviolet B course improves vitamin D balance in women in winter.
abstract: BACKGROUND
  Vitamin D insufficiency is common in winter in the Nordic countries.
  
  
  OBJECTIVE
  To examine whether a short course of narrowband ultraviolet B (NB-UVB) improves vitamin D balance.
  
  
  METHODS
  Fifty-six healthy, white women (mean age 41 years) volunteered and 53 completed the study. NB-UVB exposures were given on seven consecutive days either on the whole body (n = 19), on the head and arms (n = 9) or on the abdomen (n = 14). Similarly, seven solar simulator exposures were given on the face and arms (n = 11). The cumulative UVB dose was 13 standard erythema doses in all regimens. Serum calcidiol (25-hydroxyvitamin D) concentration was measured by radioimmunoassay before and after the NB-UVB exposures. Follow-up samples were taken from the whole-body NB-UVB group at 2 months.
  
  
  RESULTS
  At onset 41 women (77%) had vitamin D insufficiency (calcidiol < 50 nmol L(-1)) and six (11%) had vitamin D deficiency (calcidiol < 25 nmol L(-1)). Calcidiol concentration increased significantly, by a mean of 11.4 nmol L(-1) when NB-UVB was given on the whole body, by 11.0 nmol L(-1) when given on the head and arms and by 4.0 nmol L(-1) when given on the abdomen. Solar simulator exposures given on the face and arms increased calcidiol by 3.8 nmol L(-1). After 2 months serum calcidiol was still higher than initially in the group who received NB-UVB exposures on the whole body.
  
  
  CONCLUSIONS
  NB-UVB exposures given on seven consecutive days on different skin areas of healthy women significantly improved serum calcidiol concentration. A short low-dose NB-UVB course can improve vitamin D balance in winter.
authors.affiliation: Department of Dermatology, Päijät-Häme Central Hospital, Lahti, Finland. katja.vahavihu@uta.fi
authors.forename: K
authors.initials: K
authors.lastname: Vähävihu
authors.forename: L
authors.initials: L
authors.lastname: Ylianttila
authors.forename: H
authors.initials: H
authors.lastname: Kautiainen
authors.forename: H
authors.initials: H
authors.lastname: Viljakainen
authors.forename: C
authors.initials: C
authors.lastname: Lamberg-Allardt
authors.forename: T
authors.initials: T
authors.lastname: Hasan
authors.forename: P
authors.initials: P
authors.lastname: Tuohimaa
authors.forename: T
authors.initials: T
authors.lastname: Reunala
authors.forename: E
authors.initials: E
authors.lastname: Snellman
mesh_terms: D000328:Adult; D002112:Calcifediol / Q000097:blood*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005387:Finland; D006801:Humans; D008875:Middle Aged; D012621:Seasons; D012867:Skin / Q000528:radiation effects*; D055108:Sunbathing; D016896:Treatment Outcome; D014466:Ultraviolet Rays; D014467:Ultraviolet Therapy / Q000379:methods*; D014807:Vitamin D / Q000096:biosynthesis* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000628:therapy; D055815:Young Adult
chemical_list: D014807:Vitamin D; D002112:Calcifediol