title: Trials, travails and triumphs: an account of RNA catalysis in RNase P.
abstract: Last December marked the 20th anniversary of the Nobel Prize in Chemistry to Sidney Altman and Thomas Cech for their discovery of RNA catalysts in bacterial ribonuclease P (an enzyme catalyzing 5' maturation of tRNAs) and a self-splicing rRNA of Tetrahymena, respectively. Coinciding with the publication of a treatise on RNase P, this review provides a historical narrative, a brief report on our current knowledge, and a discussion of some research prospects on RNase P.
authors.affiliation: Department of Bacteriology, College of Agriculture & Life Sciences, University of Wisconsin, Madison, WI 53706, USA. wmmclain@wisc.edu
authors.forename: William H
authors.initials: WH
authors.lastname: McClain
authors.forename: Lien B
authors.initials: LB
authors.lastname: Lai
authors.forename: Venkat
authors.initials: V
authors.lastname: Gopalan
mesh_terms: D000818:Animals; D002384:Catalysis; D006801:Humans; D012313:RNA / Q000737:chemistry*; D043262:Ribonuclease P / Q000737:chemistry*
chemical_list: D012313:RNA; D043262:Ribonuclease P