title: Keratocystic odontogenic tumor associated with nevoid basal cell carcinoma syndrome: similar behavior to sporadic type?
abstract: OBJECTIVE
  The objective of this study was to analyze the expression of proliferative markers and p53 in keratocystic odontogenic tumor (KCOT) sporadic type and KCOT associated with nevoid basal cell carcinoma syndrome (NBCCS).
  
  
  METHODS
  We performed a cross-sectional study. A total of 19 patients with KCOT were selected from the Oral Pathology Laboratory archives, Central University of Venezuela, from 1995 to 2005.
  
  
  METHODS
  Twelve cases corresponded to sporadic KCOT, and seven cases were associated with NBCCS. Immunohistochemical analysis for p53, proliferating cell nuclear antigen (PCNA), and Ki-67 was performed in all 19 cases.
  
  
  RESULTS
  Of the seven cases associated with NBCCS, six (86%) were positive for PCNA. From the 12 sporadic cases, nine (75%) were positive for PCNA. Only one case of sporadic KCOT showed Ki-67 positivity. Five of 12 (42%) cases of sporadic KCOT were positive for p53, and only one (14%) case associated with NBCCS was positive for p53.
  
  
  CONCLUSIONS
  On the basis of the analysis of the expression of PCNA, Ki-67, and p53, there appears to be no evidence to indicate higher aggressiveness in growth and infiltrative behavior in syndromic KCOT compared with the sporadic type. Therefore, surgical treatment may be approached in the same manner in KCOT sporadic and syndromic with the goal of minimizing recurrence.
authors.affiliation: Oral Surgery Residency Program, Central University of Venezuela, Caracas, Venezuela.
authors.forename: Adriana
authors.initials: A
authors.lastname: Figueroa
authors.forename: Maria
authors.initials: M
authors.lastname: Correnti
authors.forename: Maira
authors.initials: M
authors.lastname: Avila
authors.forename: Aleodor
authors.initials: A
authors.lastname: Andea
authors.forename: Patricia
authors.initials: P
authors.lastname: DeVilliers
authors.forename: Helen
authors.initials: H
authors.lastname: Rivera
mesh_terms: D001478:Basal Cell Nevus Syndrome / Q000378:metabolism* / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis*; D003430:Cross-Sectional Studies; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D009361:Neoplasm Invasiveness; D009807:Odontogenic Cysts / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53