title: Textures in magnetic resonance images of the ischemic rat brain treated with an anti-inflammatory agent.
abstract: Computer-based analysis of textures in magnetic resonance images provides a higher sensitivity to textural changes that cannot be recognized by the naked human eye. Thus, there is a better potential for identifying pathophysiological processes at an earlier stage or of a different character than even a trained radiologist can find. In the present study, the potential of texture analysis for in vivo identification of the administering effect of an anti-inflammatory drug in cerebral stroke in rats was evaluated. Twenty-seven Wistar rats underwent middle cerebral artery occlusion resulting in local ischemic brain infarct. One group of rats received alpha-melanocyte stimulating hormone (alpha-MSH) and a control group received saline only. T2-weighted images, apparent diffusion maps, and T2 maps were recorded by MR. Texture features were calculated in the T2-weighted images and correlated to the apparent diffusion coefficient (ADC) and the T2 values. From an array of tested texture features three independent features were tested further. Two of which were found to provide a significant discriminative classification between the control and the alpha-MSH groups. Furthermore, the same two texture features were significantly correlated to the ADCs. Thus, quantification of texture features can be helpful in detecting the effects of stroke therapy.
authors.affiliation: MR Research Centre, Aarhus University Hospital, 8200 Aarhus N, Denmark. gangchen@mr.au.dk
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Michal
authors.initials: M
authors.lastname: Strzelecki
authors.forename: Qi
authors.initials: Q
authors.lastname: Pang
authors.forename: Hyongsuk
authors.initials: H
authors.lastname: Kim
authors.forename: Hans
authors.initials: H
authors.lastname: Stødkilde-Jørgensen
mesh_terms: D000465:Algorithms; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D010363:Pattern Recognition, Automated / Q000379:methods*; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D000521:alpha-MSH / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D000521:alpha-MSH