Toward a unified nomenclature for mammalian ADP-ribosyltransferases.
ADP-ribosylation is a post-translational modification of proteins catalyzed by ADP-ribosyltransferases. It comprises the transfer of the ADP-ribose moiety from NAD+ to specific amino acid residues on substrate proteins or to ADP-ribose itself. Currently, 22 human genes encoding proteins that possess an ADP-ribosyltransferase catalytic domain are known. Recent structural and enzymological evidence of poly(ADP-ribose)polymerase (PARP) family members demonstrate that earlier proposed names and classifications of these proteins are no longer accurate. Here we summarize these new findings and propose a new consensus nomenclature for all ADP-ribosyltransferases (ARTs) based on the catalyzed reaction and on structural features. A unified nomenclature would facilitate communication between researchers both inside and outside the ADP-ribosylation field.
Hottiger
Michael O
MO
Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. hottiger@vetbio.uzh.ch
Hassa
Paul O
PO
Lüscher
Bernhard
B
Schüler
Herwig
H
Koch-Nolte
Friedrich
F
D036002:ADP Ribose Transferases / Q000737:chemistry / Q000145:classification* / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D020134:Catalytic Domain / Q000235:genetics / Q000502:physiology; D006801:Humans; D008322:Mammals / Q000235:genetics; D011065:Poly(ADP-ribose) Polymerases / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D009626:Terminology as Topic
D036002:ADP Ribose Transferases; D011065:Poly(ADP-ribose) Polymerases