title: The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description.
abstract: OBJECTIVE
  To describe a protocol that was based on an integrative neurobiological model of scientific investigation to better understand the pathophysiology of obsessive-compulsive disorder and to present the clinical and demographic characteristics of the sample.
  
  
  METHODS
  A standardized research protocol that combines different methods of investigation (genetics, neuropsychology, morphometric magnetic resonance imaging and molecular neuroimaging of the dopamine transporter) obtained before and after treatment of drug-naïve adult obsessive-compulsive disorder patients submitted to a sequentially allocated 12-week clinical trial with a selective serotonin reuptake inhibitor (fluoxetine) and group cognitive-behavioral therapy.
  
  
  RESULTS
  Fifty-two treatment-naïve obsessive-compulsive disorder patients entered the clinical trial (27 received fluoxetine and 25 received group cognitive-behavioral therapy). At baseline, 47 blood samples for genetic studies, 50 neuropsychological evaluations, 50 morphometrical magnetic resonance images and 48 TRODAT-1 single-photon emission computed tomography (SPECT) exams were obtained. After 12 weeks, 38 patients completed the protocol (fluoxetine = 20 and GCBT = 18). Thirty-eight neuropsychological evaluations, 31 morphometrical magnetic resonance images and 34 TRODAT-1 SPECT exams were obtained post-treatment. Forty-one healthy controls matched for age, gender, socioeconomic status, level of education and laterality were submitted to the same research procedures at baseline.
  
  
  CONCLUSIONS
  The comprehensive treatment response protocol applied in this project allowing integration on genetic, neuropsychological, morphometrical and molecular imaging of the dopamine transporter data in drug-naïve patients has the potential to generate important original information on the neurobiology of obsessive-compulsive disorder, and at the same time be clinically meaningful.
authors.affiliation: Department & Institute of Psychiatry, Clinical Hospital, Medical School, Universidade de São Paulo, São Paulo, SP, Brazil. mqhoexter@gmail.com
authors.forename: Marcelo Queiroz
authors.initials: MQ
authors.lastname: Hoexter
authors.forename: Roseli Gedanke
authors.initials: RG
authors.lastname: Shavitt
authors.forename: Carina Chaubet
authors.initials: CC
authors.lastname: D'Alcante
authors.forename: Janaina Philippi
authors.initials: JP
authors.lastname: Cecconi
authors.forename: Juliana Belo
authors.initials: JB
authors.lastname: Diniz
authors.forename: Cristina
authors.initials: C
authors.lastname: Belotto-Silva
authors.forename: Ana Gabriela
authors.initials: AG
authors.lastname: Hounie
authors.forename: Sonia
authors.initials: S
authors.lastname: Borcato
authors.forename: Ivanil
authors.initials: I
authors.lastname: Moraes
authors.forename: Marines Alves
authors.initials: MA
authors.lastname: Joaquim
authors.forename: Carolina
authors.initials: C
authors.lastname: Cappi
authors.forename: Aline Santos
authors.initials: AS
authors.lastname: Sampaio
authors.forename: Maria Alice de
authors.initials: MA
authors.lastname: Mathis
authors.forename: Marcelo Camargo
authors.initials: MC
authors.lastname: Batistuzzo
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Lopes
authors.forename: Ana Carolina Ferreira
authors.initials: AC
authors.lastname: Rosa
authors.forename: Renan Kawano
authors.initials: RK
authors.lastname: Muniz
authors.forename: Andrea Horvath
authors.initials: AH
authors.lastname: Marques
authors.forename: Luciana Cristina
authors.initials: LC
authors.lastname: Santos
authors.forename: Anita
authors.initials: A
authors.lastname: Taub
authors.forename: Fábio Luís de Souza
authors.initials: FL
authors.lastname: Duran
authors.forename: Darin Dean
authors.initials: DD
authors.lastname: Dougherty
authors.forename: Geraldo Filho
authors.initials: GF
authors.lastname: Busatto
authors.forename: Rodrigo Affonseca
authors.initials: RA
authors.lastname: Bressan
authors.forename: Euripedes Constantino
authors.initials: EC
authors.lastname: Miguel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015928:Cognitive Behavioral Therapy; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D057054:Molecular Imaging; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology / Q000628:therapy*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors