title: Continuous infusion of amphotericin B deoxycholate in the treatment of cryptococcal meningoencephalitis: analysis of safety and fungicidal activity.
abstract: We measured fungicidal activity of continuous infusion of amphotericin B deoxycholate plus 5'flucytosine using quantitative cultures of cerebrospinal fluid (CSF) obtained from lumbar punctures of human immunodeficiency virus (HIV)-infected patients with neurocryptococcosis during 14 days of treatment. Glomerular renal function was preserved in all patients. Mycological efficacy with progressive reduction in CSF cryptococcal colony-forming units was comparable to standard 4-h infusion of amphotericin B.
authors.affiliation: Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil.
authors.forename: Diego Rodrigues
authors.initials: DR
authors.lastname: Falci
authors.forename: Luciano Weber
authors.initials: LW
authors.lastname: Lunardi
authors.forename: Carina Guedes
authors.initials: CG
authors.lastname: Ramos
authors.forename: Mônica Baumgardt
authors.initials: MB
authors.lastname: Bay
authors.forename: Valério Rodrigues
authors.initials: VR
authors.lastname: Aquino
authors.forename: Luciano Zubaran
authors.initials: LZ
authors.lastname: Goldani
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage* / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D002555:Cerebrospinal Fluid / Q000382:microbiology; D015169:Colony Count, Microbial; D003454:Cryptococcus / Q000187:drug effects / Q000302:isolation & purification; D003840:Deoxycholic Acid / Q000008:administration & dosage* / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005437:Flucytosine / Q000008:administration & dosage / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D016919:Meningitis, Cryptococcal / Q000188:drug therapy* / Q000382:microbiology; D050296:Microbial Viability / Q000187:drug effects; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D003840:Deoxycholic Acid; D000666:Amphotericin B; C059765:amphotericin B, deoxycholate drug combination; D005437:Flucytosine