[Evaluation of detection of Epstein-Barr virus Rta/IgG in nasopharyngeal carcinoma].
OBJECTIVE
This study was aimed to investigate the clinical value of Epstein-Barr virus (EBV) Rta/IgG in the diagnosis of nasopharyngeal carcinoma (NPC).


METHODS
Serum samples derived from 211 untreated patients with NPC, 413 subjects including 203 non-NPC ENT patients and 210 healthy volunteers as control were examined for the presence of antibodies directed against Rta/IgG by using enzyme-linked immnunosorbent assay (ELISA). Receiver operating characteristic (ROC) curve was applied to perform methodical evaluation of this tumor marker.


RESULTS
The rA value median of Rta/IgG in NPC group was significantly higher than one in control group (P < 0.001). The area under ROC was 0.933. The sensitivity and specificity of this marker were 90.5% and 90.1%, respectively, when the best cutoff value was defined.


CONCLUSIONS
Rta/IgG detected with ELISA method is a new target of EBV, and may be one of important marker for NPC diagnosis.
Zheng
Yu-Ming
YM
Central Laboratory, Wuzhou Red Cross Hospital, Guangxi 543002, China. zhengym2000@hotmail.com
Cain
Yong-Lin
YL
Cheng
Ji-Ru
JR
Li
Jun
J
Mo
Yong-Kun
YK
Gao
Jian-Quan
JQ
Dong
Zhi-Rong
ZR
Zhong
Qing-Yan
QY
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood*; D002277:Carcinoma / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D016022:Case-Control Studies; D002648:Child; D003955:Diagnostic Tests, Routine / Q000379:methods*; D020031:Epstein-Barr Virus Infections / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D017874:Immediate-Early Proteins / Q000097:blood / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D015534:Trans-Activators / Q000097:blood / Q000276:immunology*; D055815:Young Adult
D000914:Antibodies, Viral; C068382:BRLF1 protein, Human herpesvirus 4; D017874:Immediate-Early Proteins; D007074:Immunoglobulin G; D015534:Trans-Activators