A cohort study on cancer among workers exposed to an antirust oil.
An epidemiologic study in an engineering company was prompted by the observation of three cases of cancer; it revealed several more cancers among women who wrapped bearing rings covered with antirust oil, i.e., 12 cases vs 3.9 expected. The 12 tumors were situated in different organs, including the uterus, ovaries, breast, thyroid, brain, colon, and bladder. No known carcinogenic substance was found that could explain the increased incidence of cancer. If the increased incidence is not a random phenomenon, N-phenyl-1-naphthylamine or its nitroso derivative is likely to be the causative agent.
Järvholm
B
B
Department of Occupational Medicine, Sahlgrenska Sjukhuset, Göteborg, Sweden.
Lavenius
B
B
D015057:1-Naphthylamine / Q000009:adverse effects / Q000031:analogs & derivatives*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002273:Carcinogens; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007219:Industrial Oils / Q000009:adverse effects* / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology*; D009602:Nitrosamines / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D012977:Sodium Nitrite / Q000009:adverse effects; D013548:Sweden / Q000453:epidemiology
D002273:Carcinogens; D009602:Nitrosamines; C005444:N-phenyl-1-naphthylamine; D015057:1-Naphthylamine; D012977:Sodium Nitrite