title: [Pathological study of liver biopsy from 156 patients clinically diagnosed with mild chronic hepatitis B based on current guideline].
abstract: OBJECTIVE
  To study the pathological features of liver tissues from patients clinically diagnosed with mild chronic hepatitis B based on current guideline and emphasize the important significance of liver puncture and biopsy for these patients.
  
  
  METHODS
  Totally 156 patients clinically diagnosed with mild chronic hepatitis B based on current guideline received liver puncture under the real-time Doppler ultrasonographic guiding. Pathological diagnosis was made after microscopic examinations of the liver tissue specimens stained with hematoxylin-eosin (HE) and reticular fiber staining. The differences between clinical and pathological diagnosis for these patients were analyzed.
  
  
  RESULTS
  Finally, 105 (67.3%) patients were pathologically diagnosed with mild chronic hepatitis B; 28 (18.0%), 3 (1.9%) and 20 (12.8%) patients were pathologically diagnosed as moderate, severe chronic hepatitis B and cirrhosis, respectively. Forty-eight (30.8%) and 39 (25.0%) patients of non-mild chronic hepatitis B were found to have G3-4 inflammation and S3-4 fibrosis, respectively. Differences in serum alanine aminotransferase, aspartate aminotransferase, total bilirubin or albumin between mild and non-mild chronic hepatitis B based on pathological diagnosis were not statistically significant (t-test, P > 0.05).
  
  
  CONCLUSIONS
  Accurate pathological diagnosis is helpful to guiding an antiviral therapy.
authors.affiliation: Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Lu-biao
authors.initials: LB
authors.lastname: Chen
authors.forename: Hai-hui
authors.initials: HH
authors.lastname: Huang
authors.forename: Xin
authors.initials: X
authors.lastname: Shu
authors.forename: Qi-huan
authors.initials: QH
authors.lastname: Xu
authors.forename: Ni
authors.initials: N
authors.lastname: Chen
authors.forename: Ka
authors.initials: K
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D019694:Hepatitis B, Chronic / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult