title: Elevated serum levels of S100 calcium binding protein A8 (S100A8) reflect disease severity in canine atopic dermatitis.
abstract: A monoclonal antibody to canine S100 calcium binding protein A8 (S100A8) was developed to determine the association between S100A8 and the disease severity of canine atopic dermatitis. Serum S100A8 concentrations were studied in dogs with canine atopic dermatitis (n=213) and healthy dogs (n=213). Statistical correlations between these indices and atopic dermatitis activity were established, and dermatitis severity was assessed according to the CADESI score. Serum S100A8 concentrations were measured with an enzyme-linked immunosorbent assay (ELISA). S100A8 serum levels were significantly higher in canine atopic dermatitis patients than in healthy dogs. A strong positive correlation was identified between S100A8 levels and canine atopic dermatitis patients. Our findings suggested that S100A8 is actively involved in the pathogenesis and clinical picture of canine atopic dermatitis.
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Korea.
authors.forename: Tae-Ho
authors.initials: TH
authors.lastname: Chung
authors.forename: Jin-Sik
authors.initials: JS
authors.lastname: Oh
authors.forename: Yong-Soon
authors.initials: YS
authors.lastname: Lee
authors.forename: Kyung-Sun
authors.initials: KS
authors.lastname: Kang
authors.forename: Ji-Won
authors.initials: JW
authors.lastname: Jung
authors.forename: Hwa-Young
authors.initials: HY
authors.lastname: Youn
authors.forename: Cheol-Yong
authors.initials: CY
authors.lastname: Hwang
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000097:blood / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D040501:Calgranulin A / Q000097:blood* / Q000235:genetics / Q000276:immunology; D017931:DNA Primers; D003876:Dermatitis, Atopic / Q000097:blood / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D016133:Polymerase Chain Reaction; D012016:Reference Values; D012720:Severity of Illness Index
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers; D040501:Calgranulin A; D017931:DNA Primers