title: Vaginal paravaginal repair using porcine or human cadaveric dermal implant: a survival analysis.
abstract: This study was designed to compare the objective failure rate after vaginal paravaginal repair for anterior vaginal wall prolapse using either porcine or human cadaveric dermal implants. A retrospective, repeated-measures cohort study compared 72 women who underwent repair using porcine tissue implants with 45 women using cadaveric dermal implants. Anterior vaginal wall prolapse was staged preoperatively and every 6 months postoperatively. Objective failure was defined as recurrent anterior vaginal wall prolapse, stage II or greater. Life table analysis was performed. The median length of follow-up was 25 months in the cadaveric and 21 months in the porcine dermal group. The relative risk for objective failure for the porcine dermal group was 0.45 (95% confidence interval, 0.1-0.8) compared with the cadaveric dermal group. The rate of postoperative complications was similar in the two groups. The risk of recurrence of anterior vaginal prolapse is lower after surgical repair using porcine compared with cadaveric dermal implants.
authors.affiliation: Division of Urogynecology and Reconstructive Pelvic Surgery, Riverside Methodist Hospital, Columbus, Ohio 43214, USA. jnovi@ohiohealth.com
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Novi
authors.forename: Beth H K
authors.initials: BH
authors.lastname: Mulvihil
authors.forename: Lily
authors.initials: L
authors.lastname: Arya
mesh_terms: D000818:Animals; D002102:Cadaver; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D015993:Life Tables; D008875:Middle Aged; D016016:Proportional Hazards Models; D019736:Prostheses and Implants; D011475:Prosthesis Failure; D012008:Recurrence; D013552:Swine; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous; D014596:Uterine Prolapse / Q000601:surgery*; D014621:Vagina / Q000601:surgery*