[Epidemiology of the meningococcal disease in Catalonia before and after vaccination against serogroup C].
BACKGROUND
Meningococcal disease remains a serious public health problem worldwide. In Catalonia, after implementing the vaccination program, there has been a significant decrease in cases caused by meningococcus C.


METHODS
Reported cases of meningococcal disease between 1997 and 2008 were analyzed to determine the evolution after the introduction of a conjugated vaccine in Catalonia.


RESULTS
In < 6 years, the incidence rate of serogroup C fell from 7.6 to 0.6 per 100,000 persons/year in the periods before (1997-2000) and after (2001-2007) the introduction of the conjugate vaccine. In serogroup B, the reduction was from 15.4 to 11.1. In < 20 years case-fatality-rate increased only in serogroup B (3% and 7.4%). Serosubtype P1.15was the most frequent in serogroup B (31%), mainly associated with serotype 4 (80%), and in serogroup C subtype P1.5 (36%), with serotype 2a (86%). During 2008, 5 apparently unrelated cases of B:2a:P1.5 were identified in the same geographic area, with a case-fatality-rate of 80%.


CONCLUSIONS
Exhaustive surveillance of circulating meningococcal strains is essential.
Martínez
Ana I
AI
Departamento de Salud, Generalitat de Cataluña, Barcelona, España. amartinez@gencat.cat
Domínguez
Angela
A
Oviedo
Manuel
M
Minguell
Sofía
S
Jansà
Josep M
JM
Codina
Gemma
G
Vázquez
Julio A
JA
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008589:Meningococcal Infections / Q000453:epidemiology* / Q000517:prevention & control*; D022401:Meningococcal Vaccines; D038542:Neisseria meningitidis, Serogroup C; D013030:Spain / Q000453:epidemiology; D013997:Time Factors; D055815:Young Adult
D022401:Meningococcal Vaccines