Octanorcucurbitane triterpenoids protect against tert-butyl hydroperoxide-induced hepatotoxicity from the stems of Momordica charantia.
Four novel octanorcucurbitane triterpenes, octanorcucurbitacins A-D (1-4), together with one known octanorcucurbitane triterpene, kuguacin M (5), were isolated from the methyl alcohol extract of the stems of Momordica charantia. Their structures were elucidated on the basis of extensive spectroscopic analyses. Compound 3 inhibited tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity against HepG2 cells.
Chang
Chi-I
CI
Graduate Institute of Biotechnology, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan. changchii@mail.npust.edu.tw
Chen
Chiy-Rong
CR
Liao
Yun-Wen
YW
Shih
Wen-Ling
WL
Cheng
Hsueh-Ling
HL
Tzeng
Chih-Ying
CY
Li
Jia-Wei
JW
Kung
Ming-Ting
MT
D002470:Cell Survival / Q000187:drug effects; D019610:Cytoprotection; D006027:Glycosides / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D056945:Hep G2 Cells; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D029777:Momordica charantia / Q000737:chemistry*; D014315:Triterpenes / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D020122:tert-Butylhydroperoxide / Q000009:adverse effects*
D006027:Glycosides; D014315:Triterpenes; C514277:cucurbitane; D020122:tert-Butylhydroperoxide