title: Estimation of age from sclerotic glomeruli.
abstract: Glomerular sclerosis is one of the age-related causes of nephron damage. Histological studies of cadaver kidneys in several ethnic groups have shown that there is a consistent relationship between the percentage of sclerotic glomeruli (PSG) and age. However, no study regarding this relationship in the Japanese population has been reported to date. Here, we investigated such relationship in 150 Japanese cadavers that were selected regardless of clinical history. The straight line regression was estimated as follows: Age=23.3+1.36 x APSG (APSG: arcsine-transformed PSG). The R(2) value of the regression line was 0.598. The diagnostic test with the PSG value (cutoff=0.6%) for the age stratum (cutoff=33 years old) showed very high sensitivity (100%) and specificity (97.6%). From the results, PSG appears to be useful for the estimation of a cadaver's age in the Japanese population.
authors.affiliation: Department of Legal Medicine, Graduate School of Medicine, Chiba University, Chu-o-ku, Chiba, Japan. shellingford.4869@hotmail.co.jp
authors.forename: Naoki
authors.initials: N
authors.lastname: Fukuda
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sato
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yajima
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Hayakawa
authors.forename: Hisako
authors.initials: H
authors.lastname: Motani
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Katsura
authors.initials: K
authors.lastname: Otsuka
authors.forename: Sayaka
authors.initials: S
authors.lastname: Nagasawa
authors.forename: Hirotaro
authors.initials: H
authors.lastname: Iwase
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D049429:Forensic Pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D012044:Regression Analysis; D012598:Sclerosis; D012680:Sensitivity and Specificity; D055815:Young Adult