title: Early change of plasma and cerebrospinal fluid arginine vasopressin in traumatic subarachnoid hemorrhage.
abstract: OBJECTIVE
  To investigate the changes and effects of arginine vasopressin (AVP) in patients with acute traumatic subarachnoid hemorrhage (tSAH).
  
  
  METHODS
  The plasma and cerebrospinal fluid (CSF) level of AVP, and intracranial pressure (ICP) were measured in a total of 21 patients within 24 hours after tSAH. The neurological status of the patients was evaluated by Glasgow Coma Scale (GCS). Correlation between AVP and ICP, GCS was analyzed respectively. Meanwhile, 18 healthy volunteers were recruited as control group.
  
  
  RESULTS
  Compared with control group, the levels (pg/ml) of AVP in plasma and CSF (x+/-s) in tSAH group were significantly increased within 24 hours (38.72+/-24.71 vs 4.54+/-1.38 and 34.61+/-21.43 vs 4.13+/-.26, P less than 0.01), and was remarkably higher in GCS less than or equal to 8 group than GCS larger than 8 group (50.96+/-36.81 vs 25.26+/-12.87 and 44.68+/-31.72 vs 23.53+/-10.94, P less than 0.05). The CSF AVP level was correlated with ICP (r eqaul to 0.46, P less than 0.05), but no statistically significant correlation was found between plasma AVP, CSF AVP and initial GCS (r equal to -0.29, P larger than 0.05 and r equal to -0.32, P larger than 0.05, respectively). The ICP (mm Hg) in tSAH patients was elevated and higher in GCS less than or equal to 8 group than in GCS larger than 8 group (25.9+/-9.7 vs 17.6+/-5.2, P less than 0.05).
  
  
  CONCLUSIONS
  Our research suggests that AVP is correlated with the severity of tSAH, and may be involved in the pathophysiological process of brain damage in the early stage after tSAH. It seems that compared with the plasma AVP concentration, CSF AVP is more related to the severity of tSAH.
authors.affiliation: Department of Emergency, First Affiliated Hospital, Zhejiang University, Hangzhou, China.
authors.forename: Zhi-hua
authors.initials: ZH
authors.lastname: Yuan
authors.forename: Jian-yong
authors.initials: JY
authors.lastname: Zhu
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Huang
authors.forename: Jiu-kun
authors.initials: JK
authors.lastname: Jiang
authors.forename: Yuan-qiang
authors.initials: YQ
authors.lastname: Lu
authors.forename: Miao
authors.initials: M
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Su
authors.forename: Ting-ying
authors.initials: TY
authors.lastname: Jiang
mesh_terms: D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood* / Q000134:cerebrospinal fluid*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D007427:Intracranial Pressure; D008297:Male; D008875:Middle Aged; D020206:Subarachnoid Hemorrhage, Traumatic / Q000378:metabolism*
chemical_list: D001127:Arginine Vasopressin