Vascular endothelial growth factor in the aqueous humour in eyes with myopic choroidal neovascularization.
OBJECTIVE
To determine the concentration of vascular endothelial growth factor (VEGF) in the aqueous humour of eyes with myopic choroidal neovascularization (mCNV).


METHODS
Aqueous humour samples were obtained from 21 eyes of 21 patients with mCNV and from 21 eyes of 21 patients with cataract without CNV or other ocular or systemic diseases (control group). The VEGF concentration in the aqueous humour was measured using an enzyme-linked immunosorbent assay.


RESULTS
The VEGF concentrations in the aqueous humour of eyes with mCNV ranged from < 20.6 to 200 pg/ml (median 35 pg/ml). The concentrations in the control group ranged from 26 to 218 pg/ml (median 100 pg/ml). The difference between the two VEGF concentrations in the aqueous humour was significant (p < 0.001, Mann--Whitney rank sum test).


CONCLUSIONS
The VEGF concentration in the aqueous humour of patients with mCNV is lower than in normal controls. VEGF might localize in or around the CNV in eyes with mCNV.
Sawada
Osamu
O
Department of Ophthalmology, Shiga University of Medical Science, Japan. osawada@belle.shiga-med.ac.jp
Kawamura
Hajime
H
Kakinoki
Masashi
M
Sawada
Tomoko
T
Ohji
Masahito
M
D000328:Adult; D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D001082:Aqueous Humor / Q000378:metabolism*; D000068258:Bevacizumab; D002386:Cataract / Q000378:metabolism; D020256:Choroidal Neovascularization / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000378:metabolism*; D011446:Prospective Studies; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors / Q000378:metabolism*
D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab