HMGB proteins and transcriptional regulation.
In eukaryotic nuclei, transcription reactions on the chromatin are regulated by the binding of transcription regulators such as transcription factors and chromatin remodeling factors to chromatin. High-mobility-group-box (HMGB) protein family is a member of HMG super family proteins, the most abundant and ubiquitous non-histone chromatin binding proteins in eukaryotic cells. HMGB proteins bind to chromosomal DNA via their DNA binding motif, a HMG box, and induce structural changes of chromatin. Besides the chromatin binding property of HMGB proteins, HMGB proteins also interact with other proteins including transcription regulators and histones. In addition to those key transcriptional regulatory proteins, undoubtedly HMGB proteins bind dynamically to chromatin and interact with other proteins including transcription factors, thereby participating in transcription regulation in multiple processes. We will focus on the transcription regulation by HMGB proteins bound to chromatin, and possible roles of the unique structural and functional domain, the acidic C-tail region.
Ueda
Tetsuya
T
Department of Biological Science and Technology, Science University of Tokyo, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. tetsuya.ueda@pss.co.jp
Yoshida
Michiteru
M
D000818:Animals; D001483:Base Sequence; D002843:Chromatin / Q000378:metabolism; D005786:Gene Expression Regulation; D024002:HMGB Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
D002843:Chromatin; D024002:HMGB Proteins; D014157:Transcription Factors