[Hmim]TFA catalyzed multicomponent reaction: direct, mild, and efficient procedure for the synthesis of 1,2-dihydroquinazoline derivatives.
4-Substituted-spiro-1,2-dihydroquinazolines and related compounds were synthesized by direct reaction of 2-aminobenzophenones, isatin, or 1,2-diketone derivatives and ammonium acetate in the presence of dual role catalyst-solvent ionic liquid, [Hmim]TFA. Excellent conversion of starting materials was achieved to the desired 1,2-dihydroquinazoline products.
Dabiri
Minoo
M
Department of Chemistry, Faculty of Science, Shahid Beheshti University, GC, Evin, Tehran 1983963113, Iran m-dabiri@sbu.ac.ir
Bahramnejad
Mahboobeh
M
Bashiribod
Sahareh
S
D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D007093:Imidazoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry; D014269:Trifluoroacetic Acid / Q000737:chemistry*
D007093:Imidazoles; D011799:Quinazolines; D014269:Trifluoroacetic Acid