title: Sinonasal tumor in 3 dogs after successful topical treatment for frontal sinus aspergillosis.
abstract: Three dogs diagnosed with aspergillosis developed sinonasal tumors several months after successful treatment with topical clotrimazole solution. Chronic rhinosinusitis was also detected in all cases prior to diagnosis of sinonasal tumors. The inflammatory response to Aspergillus, clotrimazole treatment, and chronic inflammation after treatment are discussed as possible neoplastic promoting factors.
authors.affiliation: Department of Veterinary Clinical Sciences, Division of Veterinary Surgery, School of Veterinary Medicine, University of Milan, Italy. valentina.greci@unimi.it
authors.forename: Valentina
authors.initials: V
authors.lastname: Greci
authors.forename: Damiano
authors.initials: D
authors.lastname: Stefanello
authors.forename: Mauro
authors.initials: M
authors.lastname: Di Giancamillo
authors.forename: Carlo M
authors.initials: CM
authors.lastname: Mortellaro
mesh_terms: D000281:Administration, Intranasal; D000287:Administration, Topical; D000818:Animals; D000935:Antifungal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy; D003022:Clotrimazole / Q000009:adverse effects* / Q000627:therapeutic use; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D005626:Frontal Sinus / Q000382:microbiology / Q000473:pathology; D008297:Male; D010255:Paranasal Sinus Neoplasms / Q000139:chemically induced / Q000662:veterinary*
chemical_list: D000935:Antifungal Agents; D003022:Clotrimazole