title: Regenerative treatment with platelet-rich plasma combined with a bovine-derived xenograft in smokers and non-smokers: 12-month clinical and radiographic results.
abstract: OBJECTIVE
  The purpose of this study was to assess the healing response of intrabony defects following regenerative treatment with platelet-rich plasma (PRP) combined with a bovine-derived xenograft (BDX) in smokers and non-smokers.
  
  
  METHODS
  A total of 24 advanced chronic periodontitis patients, 12 smokers and 12 non-smokers, with 113 intrabony defects with an intrabony component of or /=3 mm were included in this study. Defects were surgically treated with PRP/BDX. At baseline and 12 months after surgery, the following parameters were recorded: plaque and sulcus bleeding indices, probing depth (PD), relative attachment level, marginal recession, probing and radiographic bone levels.
  
  
  RESULTS
  Considering the soft tissue measurements, smokers and non-smokers presented a mean PD reduction of 3.97 +/- 0.76 and 4.63 +/- 0.52 mm, recession of 0.76 +/- 0.44 and 0.50 +/- 0.12 mm and attachment gain of 3.26 +/- 0.42 and 4.06 +/- 0.40 mm, respectively. Evaluation of the hard tissue findings revealed that the mean clinical and radiographic bone gains in smokers and non-smokers were 2.83 +/- 0.47 and 3.63 +/- 0.38 mm, 2.98 +/- 0.38 and 3.67 +/- 0.48 mm, respectively. Inter-group differences for PD reduction (p<0.05), attachment (p<0.001), clinical (p<0.001) and radiographic bone gains (p<0.001) were found to be significant between smokers and non-smokers.
  
  
  CONCLUSIONS
  Within the limits of this study, the results indicate that treatment outcome following PRP/BDX application in intrabony defects is impaired with smoking.
authors.affiliation: Department of Periodontology, Dental Faculty, Yeditepe University, Goztepe, Istanbul, Turkey.
authors.forename: Selcuk
authors.initials: S
authors.lastname: Yilmaz
authors.forename: Gokser
authors.initials: G
authors.lastname: Cakar
authors.forename: Sebnem Dirikan
authors.initials: SD
authors.lastname: Ipci
authors.forename: Bahar
authors.initials: B
authors.lastname: Kuru
authors.forename: Burak
authors.initials: B
authors.lastname: Yildirim
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D000539:Alveolar Process / Q000000981:diagnostic imaging; D000818:Animals; D016025:Bone Transplantation; D002417:Cattle; D055113:Chronic Periodontitis / Q000601:surgery; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000601:surgery; D005889:Gingival Recession / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000601:surgery; D053657:Platelet-Rich Plasma; D011859:Radiography; D012907:Smoking / Q000503:physiopathology; D014183:Transplantation, Heterologous; D014945:Wound Healing / Q000502:physiology