Fluorescent in situ hybridization 1p/19q deletion/imbalance analysis of low-grade and atypical meningiomas.
The chromosomal 1p/19q state was analyzed in 16 low-grade meningiomas and 7 atypical meningiomas using fluorescent in situ hybridization (FISH) analysis. Chromosome 1p aberrations were observed in all atypical meningiomas, but in only one low-grade meningioma. Atypical meningiomas showed 19q deletion or imbalance, suggesting chromosomal instability of 19q. A small group of low-grade meningioma showed 19q aberrations. FISH 1p/19q deletion/imbalance analysis is a sensitive method for detecting chromosome aberrations of meningiomas and provides useful information for grading of meningiomas. Patients with low-grade meningioma with chromosomal instability of 1p/19q should be followed up carefully. Assessment of the chromosomal state by FISH might be of crucial importance in the clinical management of meningiomas.
Nagasaka
Toru
T
Department of Neurosurgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya, Aichi, Japan. toru-ngy@umin.ac.jp
Gunji
Masaharu
M
Hosokai
Noboru
N
Hayashi
Kumiko
K
Fujino
Masahiko
M
Ikeda
Hiroshi
H
Ito
Masafumi
M
Inao
Suguru
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D022981:Allelic Imbalance / Q000235:genetics; D043171:Chromosomal Instability / Q000235:genetics; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D004252:DNA Mutational Analysis; D005260:Female; D017353:Gene Deletion; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000503:physiopathology; D008579:Meningioma / Q000175:diagnosis* / Q000235:genetics* / Q000503:physiopathology; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D011237:Predictive Value of Tests
D005819:Genetic Markers