title: Partition coefficients of some purine derivatives and its application to pharmacokinetics.
abstract: Metazathioprine (MAZA), a methylated derivative of azathioprine (AZA), demonstrated the greatest values of apparent and specific partition coefficients in n-octanol/phosphate buffer at pH 5.7 and pH 7.4 among purine derivatives such as 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) and AZA. Introduction of a methyl group into the imidazole ring of AZA increases lipophilic properties of MAZA compared to AZA. Mass balance of purine derivatives in n-octanol and in phosphate buffer indicated their chemical stability in those media.
authors.affiliation: Department of Physical Pharmacy and Pharmacokinetics, Poznań University of Medical Sciences, Poznań, Poland. mchrzan@ump.edu.pl
authors.forename: M
authors.initials: M
authors.lastname: Chrzanowska
authors.forename: J
authors.initials: J
authors.lastname: Sobiak
authors.forename: M
authors.initials: M
authors.lastname: Kuehn
authors.forename: E
authors.initials: E
authors.lastname: Dorawa
authors.forename: T
authors.initials: T
authors.lastname: Hermann
mesh_terms: D020003:1-Octanol; D000465:Algorithms; D002021:Buffers; D007202:Indicators and Reagents; D010710:Phosphates / Q000737:chemistry; D011687:Purines / Q000737:chemistry* / Q000493:pharmacokinetics*; D012995:Solubility; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002021:Buffers; D007202:Indicators and Reagents; D010710:Phosphates; D011687:Purines; D012997:Solvents; D020003:1-Octanol