A quartz crystal microbalance-based molecular ruler for biopolymers.
We developed a quartz crystal microbalance (QCM) based molecular ruler that measures the length of surface immobilized, hydrated biopolymers (DNA and proteins). These biopolymers acted as stakes that solidified surrounding liquid at high frequency vibration in QCM measurements, which led to a simple linear frequency-thickness relation.
Ma
Hongwei
H
Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215125, PR China. hwma2008@sinano.ac.cn
He
Jian'an
J
Zhu
Zhiqiang
Z
Lv
Bei'er
B
Li
Di
D
Fan
Chunhai
C
Fang
Jing
J
D000906:Antibodies / Q000276:immunology / Q000378:metabolism; D001704:Biopolymers / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D055767:Immobilized Proteins / Q000737:chemistry; D007074:Immunoglobulin G / Q000737:chemistry; D011791:Quartz / Q000737:chemistry*
D000906:Antibodies; D001704:Biopolymers; D055767:Immobilized Proteins; D007074:Immunoglobulin G; D011791:Quartz; D004247:DNA