title: [Study on the association between chronic hepatitis B cirrhosis and HLA-DRB1 * 1301,1302 allele].
abstract: OBJECTIVE
  To investigate the association between the chronic hepatitis B cirrhosis and HLA-DRB1 * 1301,1302 gene.
  
  
  METHODS
  HLA-DRB1 * 1301,1302 allele in 27 patients with chronic hepatitis B cirrhosis and 30 patients with chronic hepatitis B was analyzed by using the polymerase chain reaction/sequence specific primer (PCR-SSP) technique.
  
  
  RESULTS
  The frenquency of HLA-DRB1 * 1301,1302 allele in the chronic hepatitis B cirrhosis group was markly higher than that in the chronic hepatitis B group.
  
  
  CONCLUSIONS
  HLA-DRB1 * 1301,1302 is closely associated with the suseptibility to chronic hepatitis cirrhosis.
authors.affiliation: Department of Infectious Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Liang
authors.forename: Zu-Jiang
authors.initials: ZJ
authors.lastname: Yu
authors.forename: He-Qing
authors.initials: HQ
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000483:Alleles; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D019694:Hepatitis B, Chronic / Q000235:genetics*; D006801:Humans; D008103:Liver Cirrhosis / Q000235:genetics*; D008297:Male
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains