title: [Pregnant women hepatitis B markers investigation and analysis of intrauterine infection].
abstract: OBJECTIVE
  To investigate the relationship between the hepatitis B virus (HBV) infection in pregnant women and intrauterine infection in local region.
  
  
  METHODS
  The markers of hepatitis B (HBVM) were determined by time-resolved fluoroimmunoassay and HBV-DNA were determined by FQ-PCR.
  
  
  RESULTS
  A total of 1262 pregnant women were examined the HBVM, 2.6%, 38.2%, 0.9%, 22.6%, 23.1% subjects were identified HBsAg, HBsAb, HBeAg, HBeAb, HBcAb positive respectively. In 33 cases of serum HBsAg-positive pregnant women, HBV-DNA were observed in most of 11 cases of pregnant women with HBeAg-positive and intrauterine infection rates were 6/11. In contrast, 22 cases of pregnant women with HBeAg negative, HBV-DNA were detected lowly-loaded and intrauterine infection rates were 2/22 (P < 0.01). Intrauterine infection rates of HBV in pregnant women with HBsAg-positive were 24.2% (8/33).
  
  
  CONCLUSIONS
  HBV infective rates in pregnant women in the local region were low. Pregnant women with serum HBeAg positive and HBV-DNA high-loaded were prone to intrauterine infection.
authors.affiliation: Central Hospital of Huzhou, Zhejiang 313000, China. lhf12345666@126.com
authors.forename: Hui-Fen
authors.initials: HF
authors.lastname: Lu
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Jin
authors.forename: Xioa-Hong
authors.initials: XH
authors.lastname: Huang
authors.forename: Qin-Ying
authors.initials: QY
authors.lastname: Zhao
authors.forename: Hua-Ying
authors.initials: HY
authors.lastname: Mao
mesh_terms: D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000097:blood* / Q000276:immunology / Q000821:virology; D006510:Hepatitis B Antibodies / Q000097:blood* / Q000276:immunology; D006511:Hepatitis B Antigens / Q000097:blood* / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood* / Q000276:immunology / Q000821:virology; D014591:Uterine Diseases / Q000097:blood* / Q000276:immunology / Q000821:virology; D055815:Young Adult
chemical_list: D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens