title: Pregnancy associated breast cancer.
abstract: Treatment of pregnancy associated breast cancer (PABC) is usually compromised as both foetal and maternal health has to be taken into consideration. We have identified on our database twelve patients with PABC and twenty-four age-matched controls diagnosed in the same time-frame. The mean age was 36 and 38 years respectively. There was no difference in time to presentation between the two groups. The mean tumour size was 48.72 mm and 26.30 mm respectively (p = 0.001). Lymphovascular invasion and lymph node involvement were more common in the PABC group. In the PABC group, 5 patients (42%) were treated with neo-adjuvant chemotherapy including one patient in first trimester. All patients underwent surgery. Adjuvant chemotherapy was given to seven (58.3%) of the PABC patients. At median follow up of 36 months, there was a single mortality and two patients (17%) had developed recurrent disease. All children are healthy with no deformity or learning disability.
authors.affiliation: Department of Surgery, University College Hospital Galway, Galway.
authors.forename: M
authors.initials: M
authors.lastname: Makgasa
authors.forename: R S
authors.initials: RS
authors.lastname: Prichard
authors.forename: C
authors.initials: C
authors.lastname: Malone
authors.forename: M J
authors.initials: MJ
authors.lastname: Kerin
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D015996:Survival Rate