title: [Manifestations of colonic dysbacteriosis in patients with drug-resistant respiratory tuberculosis].
abstract: The bacteriological and clinical manifestations of colonic dysbacteriosis were studied in 65 patients with drug-resistant respiratory tuberculosis before treatment with reserve drugs. Colonic microbiological disturbances corresponding to first-, second-, and third-degree dysbacteriosis were detected in 6 (9%), 14 (21%), and 42 (65%), respectively; no evidence of dysbacteriosis was found in 3 (5%) patients. There were characteristic clinical symptoms of dysbacteriosis (tympanism in 80% of the patients, signs of dyspepsia in 73.8%, sensation of abdominal discomfort in 69.2%, stool pattern changes in 65%). The magnitude of dysbiotic disorders was found to be associated with the severity of the tuberculous process (the extent and presence of lung tissue destruction) and the duration of previous standard chemotherapy. Intoxication and severe colonic microenvironmental disturbances were ascertained to have a mutual impact. Gastrointestinal comorbidity in remission did not affect the severity of colonic dysbacteriosis in patients with drug-resistant pulmonary tuberculosis.
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Tsygina
authors.forename: T V
authors.initials: TV
authors.lastname: Chebotareva
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003108:Colonic Diseases / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D012426:Russia / Q000453:epidemiology; D018088:Tuberculosis, Multidrug-Resistant / Q000150:complications* / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000382:microbiology; D055815:Young Adult