title: Diagnostic considerations and prosthetic rehabilitation of a cocaine-induced midline destructive lesion: A clinical report.
abstract: The intranasal inhalation of cocaine has numerous complications. In addition to its systemic effects, cocaine can cause extensive destruction of the osteocartilaginous midline structures of the palate, nose, and sinuses. Without an accurate social and clinical history, a cocaine-induced midline destructive lesion can cause diagnostic difficulties, because its clinical presentation closely mimics other diseases. This clinical report describes an oronasal defect caused by cocaine use, the diagnostic considerations of these lesions, and prosthetic management of the defect.
authors.affiliation: Assistant Professor, Department of Head and Neck Surgery, Section of Oncologic Dentistry and Prosthodontics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas TX 77030-4009, USA. thofstede@mdanderson.org
authors.forename: Theresa M
authors.initials: TM
authors.lastname: Hofstede
authors.forename: Rhonda F
authors.initials: RF
authors.lastname: Jacob
mesh_terms: D000280:Administration, Inhalation; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000009:adverse effects; D003042:Cocaine / Q000008:administration & dosage / Q000009:adverse effects; D019970:Cocaine-Related Disorders / Q000150:complications / Q000473:pathology* / Q000601:surgery; D017267:Dental Prosthesis Design; D019094:Dental Prosthesis, Implant-Supported; D003937:Diagnosis, Differential; D014890:Granulomatosis with Polyangiitis / Q000473:pathology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009668:Nose Diseases / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D016155:Oral Fistula / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D013516:Oral Surgical Procedures, Preprosthetic / Q000379:methods; D056948:Orthognathic Surgical Procedures / Q000379:methods; D010158:Palatal Obturators; D021362:Palate, Hard / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants; D003042:Cocaine