title: Bioactive phenylpropanoids from Daucus crinitus Desf. from Algeria.
abstract: The volatile constituents of Daucus crinitus Desf. from Algeria were analyzed by GC and GC-MS, The main constituent was isochavicol isobutyrate (39.0%), an uncommon phenylpropanoid. By synthesis of a series of homologous esters, it was also possible to determine the presence of small amounts of isochavicol propionate, which has never been described previously as a natural product. The antibacterial and antifungal activities of the whole essential oil, of these two esters, and of isochavicol itself were investigated against a wide range of bacteria and fungi. Additionally, their antimalarial and antiradical properties were also evaluated, showing an interesting antiplasmodial activity of isochavicol.
authors.affiliation: Université de Corse-CNRS, UMR 6134 SPE, Equipe Chimie et Biomasse, Route des Sanguinaires, 20000 Ajaccio, France.
authors.forename: Don-Antoine
authors.initials: DA
authors.lastname: Lanfranchi
authors.forename: Hocine
authors.initials: H
authors.lastname: Laouer
authors.forename: Meriem
authors.initials: M
authors.lastname: El Kolli
authors.forename: Soizic
authors.initials: S
authors.lastname: Prado
authors.forename: Christine
authors.initials: C
authors.lastname: Maulay-Bailly
authors.forename: Nicolas
authors.initials: N
authors.lastname: Baldovini
mesh_terms: D000462:Algeria; D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology; D019661:Apiaceae / Q000737:chemistry*; D001234:Aspergillus niger / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects; D004952:Esters / Q000302:isolation & purification / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D009822:Oils, Volatile / Q000302:isolation & purification* / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000981:Antiprotozoal Agents; D004952:Esters; D009822:Oils, Volatile