title: Assessment and interpretation of comorbidity burden in older adults with cancer.
abstract: OBJECTIVE
  To evaluate the associations between comorbidities, functional limitations, geriatric syndromes, treatment patterns, and outcomes in a population-based cohort of older patients diagnosed with colorectal cancer and receiving home health care.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Data from the Ohio Cancer Incidence Surveillance System, Medicare claims and enrollment files, and the home health care Outcome and Assessment Information Set.
  
  
  METHODS
  Ohio residents diagnosed with incident colorectal cancer in 1999 to 2001 and receiving home health care in the 30 days before or after cancer diagnosis (N=957).
  
  
  METHODS
  Outcome measures included receipt of cancer treatment and survival through 2005.
  
  
  RESULTS
  Not having surgery was associated negatively with comorbidities but positively with functional limitations and geriatric syndromes. Receipt of chemotherapy was negatively associated with comorbidities and functional limitations. The presence of two or more geriatric syndromes was significantly associated with unfavorable survival outcomes when analyzing overall survival and disease-specific survival (DSS). Having limitations in two or more activities of daily living was associated with unfavorable overall survival but not with DSS. Comorbity was associated with favorable DSS at borderline level of statistical significance but not with overall survival.
  
  
  CONCLUSIONS
  The findings highlight the importance of incorporating functional limitations and geriatric syndrome data in geriatric oncology outcomes studies.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. skoroukian@case.edu
authors.forename: Siran M
authors.initials: SM
authors.lastname: Koroukian
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000150:complications* / Q000401:mortality / Q000628:therapy*; D017281:Cost of Illness; D005260:Female; D006699:Home Care Services; D006801:Humans; D008297:Male; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D015996:Survival Rate; D013577:Syndrome