Concentration-dependent effect of (-) epicatechin in hypertensive patients.
Non-vitamin polyphenolic compounds are ubiquitous in food plants and therefore potentially present in human plasma in a diet-dependent concentration. The aim of this study was to evaluate the concentration-dependent effect of (-) epicatechin, a polyphenol present in green tea with antioxidant activity, on various biomarkers of oxidative stress. The current study examined the in vitro concentration-dependent (10(-4) M to 10(-7) M) effects of (-) epicatechin on biomarkers of oxidative stress viz. malondialdehyde (MDA), reduced glutathione (GSH), membrane sulfhydryl (-SH) group and protein carbonyl content in hypertensive patients and normal ones. This effect seems to be due to ability of (-) epicatechin to reduce MDA and protein carbonyl content while increase in GSH and membrane -SH group in hypertensive patients. It can be concluded that (-) epicatechin exerts an antioxidant action inside the cell, responsible for the observed modulation of cellular response to oxidative challenges.
Kumar
Navneet
N
Doon PG Paramedical College & Hospital, Dehradun UK, India.
Kant
Ruchi
R
Maurya
Pawan Kumar
PK
D000975:Antioxidants / Q000494:pharmacology*; D016022:Case-Control Studies; D002392:Catechin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects; D005978:Glutathione / Q000097:blood / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D050050:Protein Carbonylation
D000975:Antioxidants; D008315:Malondialdehyde; D002392:Catechin; D005978:Glutathione