Effect of flavonoids from Exellodendron coriaceum (Chrysobalanaceae) on glucose-6-phosphatase.
From the n-butanol extract of the aerial parts of Exellodendron coriaceum (Benth.) Prance the flavonoids quercetin-3-O-beta-D-galactopyranoside (1), quercetin-3-O-alpha-L-arabinopyranoside (2), quercetin-3-O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-rhamnopyranoside (3), and quercetin-3-O-alpha-L-rhamnopyranosyl-(1-->6)-beta-D-galactopyranoside (4) were isolated. Additionally from this extract three flavonoids were isolated and partially characterized as quercetin glycosides. All these compounds were tested for their hypoglycemic activity using the glucose-6-phosphatase microsomal hepatic system. The flavonoids inhibited the activity of the enzyme when intact microsomes were used, the highest percentage of inhibition being 65%. To the best of our knowledge, this is the first report of chemical and biological activity of E. coriaceum.
Carrasco
Diana
D
Laboratorio de Productos Naturales, Escuela de Química, Facultad de Ciencias, Universidad Central de Venezuela, Apartado Postal 47102, Caracas 1020-A, Venezuela. diana.carrasco@ciens.ucv.ve
Méndez
Jeannette
J
Braca
Alessandra
A
De Leo
Marinella
M
González-Mujica
Freddy
F
Duque
Sandra
S
D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D005952:Glucose-6-Phosphatase / Q000037:antagonists & inhibitors*; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000302:isolation & purification; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D018515:Plant Leaves / Q000737:chemistry; D011794:Quercetin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D005419:Flavonoids; D007004:Hypoglycemic Agents; D011794:Quercetin; D005952:Glucose-6-Phosphatase