title: Insertion and deletion processes in recent human history.
abstract: BACKGROUND
  Although insertions and deletions (indels) account for a sizable portion of genetic changes within and among species, they have received little attention because they are difficult to type, are alignment dependent and their underlying mutational process is poorly understood. A fundamental question in this respect is whether insertions and deletions are governed by similar or different processes and, if so, what these differences are.
  
  
  RESULTS
  We use published resequencing data from Seattle SNPs and NIEHS human polymorphism databases to construct a genomewide data set of short polymorphic insertions and deletions in the human genome (n = 6228). We contrast these patterns of polymorphism with insertions and deletions fixed in the same regions since the divergence of human and chimpanzee (n = 10,546). The macaque genome is used to resolve all indels into insertions and deletions. We find that the ratio of deletions to insertions is greater within humans than between human and chimpanzee. Deletions segregate at lower frequency in humans, providing evidence for deletions being under stronger purifying selection than insertions. The insertion and deletion rates correlate with several genomic features and we find evidence that both insertions and deletions are associated with point mutations. Finally, we find no evidence for a direct effect of the local recombination rate on the insertion and deletion rate.
  
  
  CONCLUSIONS
  Our data strongly suggest that deletions are more deleterious than insertions but that insertions and deletions are otherwise generally governed by the same genomic factors.
authors.affiliation: Bioinformatics Research Center, C. F. Møllers Alle, Arhus, Denmark. persj@cs.au.dk
authors.forename: Per
authors.initials: P
authors.lastname: Sjödin
authors.forename: Thomas
authors.initials: T
authors.lastname: Bataillon
authors.forename: Mikkel H
authors.initials: MH
authors.lastname: Schierup
mesh_terms: D030541:Databases, Genetic; D006801:Humans; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic