Hepatoprotective activity of hydroalcoholic extract of leaves of Alocasia indica (Linn.).
Oral administration of hydroalcoholic extract of A. indica (250 and 500 mg/kg) effectively inhibited CCl4 and paracetamol induced changes in the serum marker enzymes, cholesterol, serum protein and albumin in a dose-dependent manner as compared to the normal and the standard drug silymarin-treated groups. Hepatic steatosis, fatty infiltration, hydropic degeneration and necrosis observed in CCl4 and paracetamol-treated groups were completely absent in histology of the liver sections of the animals treated with the extracts. The results suggests that the hydroalcoholic extract of leaves of A. indica possess significant potential as hepatoprotective agent.
Mulla
Wahid A
WA
Government College of Pharmacy, Vidyanagar, Karad 415 124, India. wahidmulla@gmail.com
Salunkhe
Vijay R
VR
Bhise
Satish B
SB
D000082:Acetaminophen / Q000633:toxicity; D031055:Alocasia / Q000737:chemistry*; D000818:Animals; D000431:Ethanol / Q000737:chemistry; D005260:Female; D008099:Liver / Q000187:drug effects*; D008111:Liver Function Tests; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D000082:Acetaminophen; D000431:Ethanol