Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure.
The natural tetracyclic schweinfurthins are potent and selective inhibitors of cell growth in the National Cancer Institute's 60-cell line screen. An interest in determination of their cellular or molecular target has inspired our efforts to prepare both the natural products and analogues. In this paper, chemical synthesis of analogues modified in different olefinic positions, and preliminary results from studies of their biological activity, are reported.
Ulrich
Natalie C
NC
Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA.
Kodet
John G
JG
Mente
Nolan R
NR
Kuder
Craig H
CH
Beutler
John A
JA
Hohl
Raymond J
RJ
Wiemer
David F
DF
D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015335:Molecular Probes; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D013267:Stilbenes / Q000737:chemistry*
D015335:Molecular Probes; D013267:Stilbenes; C518723:schweinfurthin F