Synthesis, characterization and cytotoxic/cytostatic activity of La(III) and Dy(III) complexes.
New La(III) and Dy(III) complexes of deprotonated 4-hydroxy-3[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one (Acenocoumarol) were synthesized and characterized using FT-IR, FT-Raman, (1)H NMR spectra, and elemental analyses. The ligand and its lanthanide(III) complexes were tested for their cytotoxic/cytostatic activity against two tumor cell lines and peritoneal mouse macrophages. The La(III) and Dy(III) complexes exhibit good activity against melanoma B16 and fibrosarcoma L929 and they are stronger inhibitors of tumor cell proliferation compared to the ligand without influencing normal cell viability and NO release by mouse peritoneal macrophages.
Kostova
Irena
I
Department of Chemistry, Faculty of Pharmacy, Medical University, 2 Dunav St., Sofia 1000, Bulgaria. irenakostova@yahoo.com
Stefanova
Tsvetanka
T
D000074:Acenocoumarol / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D054697:Cytostatic Agents / Q000737:chemistry* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D004419:Dysprosium / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D007811:Lanthanum / Q000737:chemistry* / Q000633:toxicity; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013059:Spectrum Analysis, Raman; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D054697:Cytostatic Agents; D008024:Ligands; D004419:Dysprosium; D007811:Lanthanum; D000074:Acenocoumarol