Short term testosterone replacement therapy improves libido and body composition.
OBJECTIVE
To assess the efficacy and safety of testosterone replacement in males with late-onset hypogonadism compared to hypogonadal men without replacement, and controls, during six months.


METHODS
We assessed, through ADAM, AMS, IIEF-5 and SF-36 questionnaires, and through clinical and laboratory examinations, 62 patients divided into three groups: 17 hypogonadal males (HR) used intramuscular testosterone every three weeks; 14 hypogonadal males (HV) and 31 non-hypogonadal males (CV) used oral vitamins daily.


RESULTS
When compared to others, HR group obtained libido improvement assessed by ADAM 1 (p = 0.004), and borderline sexual potency improvement assessed by IIEF-5 (p = 0.053), besides a decrease in waist circumference after eight weeks (p = 0.018). The remaining parameters did not differ between the groups. PSA and hematocrit remained stable in those using testosterone.


CONCLUSIONS
Six months of testosterone replacement improved sexuality and body composition, with prostatic and hematological safety.
Andrade
Edésio Seara de
ES
Divisão de Endocrinologia Feminina e Andrologia, Setor de Endocrinologia, Hospital da Lagoa, Rio de Janeiro, RJ, Brasil. junioredesio@hotmail.com
Clapauch
Ruth
R
Buksman
Salo
S
D000368:Aged; D000728:Androgens / Q000008:administration & dosage* / Q000009:adverse effects; D001823:Body Composition / Q000187:drug effects*; D004812:Epidemiologic Methods; D020249:Hormone Replacement Therapy / Q000009:adverse effects; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000188:drug therapy*; D007989:Libido / Q000187:drug effects*; D008297:Male; D013739:Testosterone / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors; D055105:Waist Circumference / Q000187:drug effects
D000728:Androgens; D013739:Testosterone