Host-guest interaction mediated polymeric assemblies: multifunctional nanoparticles for drug and gene delivery.
Novel core-shell structured nanoassemblies are assembled by a beta-cyclodextrin containing a positively charged host polymer and a hydrophobic guest polymer. The hydrophobic core of these types of assemblies serves as a nanocontainer to load and release the hydrophobic drugs, while the positively charged hydrophilic shell is able to condense the plasmid DNA and achieve its transfection/expression in osteoblast cells. These assemblies may be used as a new generation of multifunctional nanocarriers for simultaneous drug delivery and gene therapy.
Zhang
Jianxiang
J
Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Sun
Hongli
H
Ma
Peter X
PX
D000818:Animals; D002460:Cell Line; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D003907:Dexamethasone / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D018014:Gene Transfer Techniques; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D010316:Particle Size; D010455:Peptides / Q000737:chemistry; D011094:Polyethyleneimine / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D013997:Time Factors; D047392:beta-Cyclodextrins / Q000737:chemistry
D004337:Drug Carriers; D010455:Peptides; D011108:Polymers; D047392:beta-Cyclodextrins; C033141:poly-beta-benzyl-aspartate; D003907:Dexamethasone; D011094:Polyethyleneimine; D004247:DNA