title: Light-curable polymer/calcium phosphate nanocomposite glue for bone defect treatment.
abstract: Light-curable, methacrylate-based resins are clinically used for complex defect repair in dentistry (Heliobond). The present study investigates how such easy-to-apply polymers may be used on a much broader range of applications, particularly for gluing wet bone. We investigate the significantly improved adhesion of the polymer to wet bone surfaces in a close to in vivo setup using freshly cut cow hip bone as a model. The use of a reactive filler (20 wt.% amorphous, glassy calcium phosphate nanoparticles, a-CaP) allows for combination of the properties of the polymer (strength; light-curing) and the reactive filler (recrystallization of amorphous CaP to hydroxyapatite within minutes). This filler alone has been earlier suggested for use as an injectable bone cement since it reacts under in vivo conditions within 10-15 min. Our study transfers this reactivity into a composite, thus using the reactive CaP phase to establish an improved adhesion of the composite to wet bone surfaces. Additional in vitro bioactivity tests, compressive and tensile strength suggest use of such light-curable nanocomposites for complex-shaped load-bearing implant materials and fracture repair.
authors.affiliation: Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.
authors.forename: Oliver D
authors.initials: OD
authors.lastname: Schneider
authors.forename: Alexander
authors.initials: A
authors.lastname: Stepuk
authors.forename: Dirk
authors.initials: D
authors.lastname: Mohn
authors.forename: Norman A
authors.initials: NA
authors.lastname: Luechinger
authors.forename: Kirill
authors.initials: K
authors.lastname: Feldman
authors.forename: Wendelin J
authors.initials: WJ
authors.lastname: Stark
mesh_terms: D001842:Bone and Bones / Q000002:abnormalities*; D002130:Calcium Phosphates; D008027:Light; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites; D011108:Polymers; D014014:Tissue Adhesives
chemical_list: D002130:Calcium Phosphates; D011108:Polymers; D014014:Tissue Adhesives; C020243:calcium phosphate