Deregulation of H3K27 methylation in cancer.
A new study now reports recurrent somatic mutation of EZH2, a histone methyltransferase that modifies H3K27, in diffuse large B-cell lymphoma (DLBCL). There is now evidence for both increased and decreased activity of enzymes controlling H3K27 methylation in cancer, suggesting that a precise balance of this methylation is critical for normal cell growth.
Martinez-Garcia
Eva
E
Licht
Jonathan D
JD
D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics; D000071221:Enhancer of Zeste Homolog 2 Protein; D018858:Germinal Center / Q000378:metabolism / Q000473:pathology; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008224:Lymphoma, Follicular / Q000235:genetics*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000473:pathology; D008239:Lysine / Q000378:metabolism*; D008745:Methylation; D009154:Mutation / Q000235:genetics; D063151:Polycomb Repressive Complex 2; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics
D004268:DNA-Binding Proteins; D006657:Histones; D014157:Transcription Factors; C498409:EZH2 protein, human; D000071221:Enhancer of Zeste Homolog 2 Protein; D063151:Polycomb Repressive Complex 2; D008239:Lysine