title: McKittrick-Wheelock syndrome: a rare cause of life-threatening electrolyte disturbances and volume depletion.
abstract: BACKGROUND
  It is uncommon for emergency physicians to discover a patient with circulatory failure resulting from chronic diarrhea.
  
  
  OBJECTIVE
  We describe McKittrick-Wheelock syndrome, a rare disorder characterized by volume and electrolyte depletion and caused by colonic neoplasm.
  
  
  METHODS
  The case of a 30-year-old woman who came to the Emergency Department with hypovolemic shock, hyponatremia, and hypokalemia with a background of chronic diarrhea is reported. The hypokalemia and dehydration were refractory to aggressive replacement therapy. Her condition was the result of fluid and electrolyte hypersecretion caused by a colonic adenocarcinoma and colonic polyposis. Surgical removal of the colon and subsequent volume and electrolyte replacement therapy resulted in complete recovery.
  
  
  CONCLUSIONS
  This case is presented to increase awareness among emergency physicians of the rare disorder of McKittrick-Wheelock syndrome.
authors.affiliation: Department of Emergency Medicine, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Yu-Sung
authors.initials: YS
authors.lastname: Lee
authors.forename: Hung-Jung
authors.initials: HJ
authors.lastname: Lin
authors.forename: Kuo-Tai
authors.initials: KT
authors.lastname: Chen
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000601:surgery; D000328:Adult; D002908:Chronic Disease; D003110:Colonic Neoplasms / Q000150:complications / Q000601:surgery; D003111:Colonic Polyps / Q000150:complications / Q000601:surgery; D003967:Diarrhea / Q000150:complications* / Q000209:etiology; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000209:etiology*; D007010:Hyponatremia / Q000209:etiology*; D012769:Shock / Q000209:etiology*; D013577:Syndrome; D014883:Water-Electrolyte Imbalance / Q000209:etiology*