[The expression stathmin gene in laryngeal squamous cell carcinoma].
OBJECTIVE
To observe expression of stathmin gene in laryngeal squamous cell carcinoma (LSCC) and relation between expression of stathmin gene and occurrence and development of LSCC.


METHODS
The expression of the stathmin gene was determined in 35 LSCC of specimens and 18 normal laryngeal tissues (NLT) of specimens by in situ hybridization with Digoxigenin labeled probe of stathmin mRNA.


RESULTS
Expression of stathmin gene was observed in 35 cases of laryngeal squamous cell carcinoma tissue (positive rate, 69%) and positive signal was observed in both cytoplasm and nuclear. Among 18 cases of normal tissue, only 6 showed weak positive signal. There was significant difference in expression of stathmin gene between laryngeal squamous cell carcinoma tissue and normal tissue.


CONCLUSIONS
Expression of stathmin gene may play a key role in the pathogenesis and development of laryngeal squamous cell carcinoma. It may be a very important biotherapy target in the treatment of laryngeal squamous cell carcinoma.
Zhang
Xuecong
X
Department of Otolaryngology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Cao
Hua
H
Gao
Dongling
D
D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics; D050777:Stathmin / Q000235:genetics / Q000378:metabolism*
D012333:RNA, Messenger; C493995:STMN1 protein, human; D050777:Stathmin