Biodistribution of technetium-99m pertechnetate after Roux-en-Y gastric bypass (Capella technique) in rats.
OBJECTIVE
The biodistribution of sodium pertechnetate, the most used radiopharmaceutical in nuclear medicine, has not been studied in details after bariatric surgery. The objective was to investigate the effect of Roux-en-Y gastric bypass (RYGB) on biodistribution of sodium pertechnetate (Na(99m)Tc(-)) in organs and tissues of rats.


METHODS
Twelve rats were randomly divided into two groups of 6 animals each. The RYGB group rats were submitted to the Roux-en-Y gastric bypass and the control group rats were not operated. After 15 days, all rats were injected with 0.1 mL of Na(99m)Tc(-) via orbital plexus with average radioactivity of 0.66 MBq. After 30 minutes, liver, stomach, thyroid, heart, lung, kidney and femur samples were harvested, weighed and percentage of radioactivity per gram (%ATI/g) of each organ was determined by gama counter Wizard Perkin-Elmer. We applied the Student t test for statistical analysis, considering p<0.05 as significant.


RESULTS
Significant reduction in mean %ATI/g was observed in the liver, stomach and femur in the RYGB group animals, compared with the control group rats (p<0.05). In other organs no significant difference in %ATI/g was observed between the two groups.


CONCLUSIONS
This work contributes to the knowledge that the bariatric surgery RYGB modifies the pattern of biodistribution of Na(99m)Tc(-).
Rêgo
Amália Cínthia Meneses do
AC
Department of Surgery, School of Medicine, Federal University of Rio Grande do Norte (UFRN), Natal, Brazil.
Araújo-Filho
Irami
I
Azevedo
Italo Medeiros
IM
Jácome
Daniel Tôrres
DT
Ramalho
Rachel de Alcântara Oliveira
Rde A
Medeiros
Aldo Cunha
AC
D000818:Animals; D005269:Femur / Q000378:metabolism; D015390:Gastric Bypass / Q000009:adverse effects* / Q000379:methods; D005753:Gastric Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D023421:Models, Animal; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013670:Sodium Pertechnetate Tc 99m / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m