Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop.
Radiation exposures from accidents, nuclear detonations or terrorist incidents are unlikely to be homogeneous; however, current biodosimetric approaches are developed and validated primarily in whole-body irradiation models. A workshop was held at the Armed Forces Radiobiology Research Institute in May 2008 to draw attention to the need for partial-body biodosimetry, to discuss current knowledge, and to identify the gaps to be filled. A panel of international experts and the workshop attendees discussed the requirements and concepts for a path forward. This report addresses eight key areas identified by the Workshop Program Committee for future focus: (1) improved cytogenetics, (2) clinical signs and symptoms, (3) cutaneous bioindicators, (4) organ-specific biomarkers, (5) biophysical markers of dose, (6) integrated diagnostic approaches, (7) confounding factors, and (8) requirements for post-event medical follow-up. For each area, the status, advantages and limitations of existing approaches and suggestions for new directions are presented.
Prasanna
Pataje G S
PG
Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889, USA. patajeprasanna@mail.nih.gov
Blakely
William F
WF
Bertho
Jean-Marc
JM
Chute
John P
JP
Cohen
Eric P
EP
Goans
Ronald E
RE
Grace
Marcy B
MB
Lillis-Hearne
Patricia K
PK
Lloyd
David C
DC
Lutgens
Ludy C H W
LC
Meineke
Viktor
V
Ossetrova
Natalia I
NI
Romanyukha
Alexander
A
Saba
Julie D
JD
Weisdorf
Daniel J
DJ
Wojcik
Andrzej
A
Yukihara
Eduardo G
EG
Pellmar
Terry C
TC
D015415:Biomarkers / Q000032:analysis*; D006801:Humans; D011832:Radiation Injuries / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*
D015415:Biomarkers