title: Combinatorial vector fields and the valley structure of fitness landscapes.
abstract: Adaptive (downhill) walks are a computationally convenient way of analyzing the geometric structure of fitness landscapes. Their inherently stochastic nature has limited their mathematical analysis, however. Here we develop a framework that interprets adaptive walks as deterministic trajectories in combinatorial vector fields and in return associate these combinatorial vector fields with weights that measure their steepness across the landscape. We show that the combinatorial vector fields and their weights have a product structure that is governed by the neutrality of the landscape. This product structure makes practical computations feasible. The framework presented here also provides an alternative, and mathematically more convenient, way of defining notions of valleys, saddle points, and barriers in landscape. As an application, we propose a refined approximation for transition rates between macrostates that are associated with the valleys of the landscape.
authors.affiliation: Max Planck Institute for Mathematics in the Sciences, Inselstrasse 22, Leipzig, Germany. baer@bioinf.uni-leipzig.de
authors.forename: Bärbel M R
authors.initials: BM
authors.lastname: Stadler
authors.forename: Peter F
authors.initials: PF
authors.lastname: Stadler
mesh_terms: D019143:Evolution, Molecular; D008957:Models, Genetic; D012641:Selection, Genetic