Tamarindus indica L. and Moringa oleifera M. extract administration ameliorates fluoride toxicity in rabbits.
Aqueous extracts of T. indica fruit pulp (100 mg/kg body weight) and M. oleifera seeds (50 mg/kg body wight) orally once daily for 90 days lowered plasma fluoride concentrations in rabbits receiving fluorinated drinking water (200 mg NaF/ Liter water). Cortical indices and metaphysial width in animals receiving extracts also revealed beneficial effects of plant extracts. Changes in plasma biochemistry suggested less hepatic and renal damages in animals receiving plant extracts along with fluorinated water in comparison to that receiving fluorinated water alone. Preliminary results revealed these plant extracts have some potential to mitigate fluoride toxicity.
Ranjan
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Division of Medicine, Indian Veterinary Research Institute, Izatnagar 243 122, India. rakesh_ranjan3@rediffmail.com
Swarup
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Patra
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Chandra
Vikas
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D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D005459:Fluorides / Q000633:toxicity*; D008297:Male; D029588:Moringa oleifera / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D011817:Rabbits; D029861:Tamarindus / Q000737:chemistry*
D000931:Antidotes; D010936:Plant Extracts; D005459:Fluorides