The conductivity measurements applied for the evaluation of controlled release of chlorhexidine from thermosensitive N-isopropylacrylamide derivative microgels.
The aim of the work was the evaluation of the conductivity changes in aqueous environment, consisting of chlorhexidine, and N-isopropylacrylamide derivative microgel, during increasing the temperature between 25 degrees C and 42 degrees C, as a prerequisite to develop the this microgel for controlled release of chlorhexidine, when alterations in temperature are involved. Conductivity of studied systems underwent specific alterations, when temperature increased. For the system with polymer PNM I the values of conductivity were in the range 104,47 microS/cm - 134,70 microS/ cm, for temperature range 25 degrees C and 42 degrees C. In the case of PNM II - CX system, respective values reached 91,75 microS/cm - 135,95 microS/cm. The lowest conductivity values were observed when PNM III - CX mixture was studied: 96,90 microS/cm and 117,37 microS/cm. When a complex of derivatives of N-isopropylacrylamide with chlorhexidine undergoes thermal alteration, there is a potential to obtain controlled release of chlorhexidine from the polymeric bead in the range between 25 degrees C and 42 degrees C. The affinity of chlorhexidine to the polymer may be assessed in this systems applying the conductivity measurements. The solubility of chlorhexidine in the polymeric systems should be in future evaluated, to determine role of this factor in the conductivity alterations.
Musiał
Witold
W
University of Maribor, Department for Textile Materials and Design, Laboratory for Chemistry Dyes and Polymers, Slovenia. witold@ktpl.am.wroc.pl
Kokol
Vanja
V
Voncina
Bojana
B
D000178:Acrylamides / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry*; D002710:Chlorhexidine / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004553:Electric Conductivity; D005782:Gels / Q000737:chemistry; D006361:Heating; D011108:Polymers / Q000737:chemistry*
D000178:Acrylamides; D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005782:Gels; D011108:Polymers; C067295:N-isopropylacrylamide; D002710:Chlorhexidine