Human copper homeostasis: a network of interconnected pathways.
Copper plays an essential role in normal human physiology. Copper misbalance affects heart development, CNS and liver function, influences lipid metabolism, inflammation, and resistance to chemotherapeutic drugs. Recent studies yielded new information on the structure, function, and regulation of human copper transporters, uncovered unanticipated functions for copper chaperones, and established connections between copper homeostasis and other metabolic pathways. It has become apparent that the copper trafficking machinery is regulated at several levels and that the cross-talk between cell compartments contributes to the intracellular copper balance. The human copper regulon is emerging.
Lutsenko
Svetlana
S
Department of Physiology, Johns Hopkins University, Baltimore, MD 21205, USA. lutsenko@jhmi.edu
D000595:Amino Acid Sequence; D000818:Animals; D027682:Cation Transport Proteins / Q000737:chemistry / Q000378:metabolism*; D003300:Copper / Q000378:metabolism*; D006801:Humans; D017136:Ion Transport; D008958:Models, Molecular; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D027682:Cation Transport Proteins; D003300:Copper