title: Synthesis of new imidazolidin-2,4-dione and 2-thioxoimidazolidin-4-ones via C-phenylglycine derivatives.
abstract: Hydantoins and their derivatives constitute a group of pharmaceutical compounds with anticonvulsant and antiarrhythmic properties, and are also used against diabetes. N-3 and C-5 substituted imidazolidines are examples of such products. As such, we have developed a synthesis of 2,4-dione and 2-thioxo-4-one imidazolidinic derivatives by reaction of amino acids with C-phenylglycine, phenyl isocyanate and phenyl isothiocyanate. Four amino-derivatives IG(1-4) and eight imidazolidinic derivatives, IM(1-8), were obtained in yields of 70-74%. The mass, infrared, (1)H and (13)C-NMR spectra of representative products are discussed.
authors.affiliation: Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa-PB, CEP 58.051-970, Brazil.
authors.forename: José Alixandre
authors.initials: JA
authors.lastname: de Sousa Luis
authors.forename: José Maria
authors.initials: JM
authors.lastname: Barbosa Filho
authors.forename: Bruno
authors.initials: B
authors.lastname: Freitas Lira
authors.forename: Isac
authors.initials: I
authors.lastname: Almeida Medeiros
authors.forename: Liana Clébia
authors.initials: LC
authors.lastname: Soares Lima de Morais
authors.forename: Raline Mendonça
authors.initials: RM
authors.lastname: dos Anjos
authors.forename: Alexsandro Fernandes
authors.initials: AF
authors.lastname: Dos Santos
authors.forename: Cledualdo
authors.initials: C
authors.lastname: Soares de Oliveira
authors.forename: Petrônio Filgueiras
authors.initials: PF
authors.lastname: de Athayde-Filho
mesh_terms: D005998:Glycine / Q000031:analogs & derivatives* / Q000737:chemistry*; D048289:Imidazolidines / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013867:Thiohydantoins / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D048289:Imidazolidines; D013867:Thiohydantoins; C514490:imidazolidine-2,4-dione; C008852:2-phenylglycine; D005998:Glycine