title: A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients.
abstract: Single clustering methods have often been used to elucidate clusters in high dimensional medical data, even though reliance on a single algorithm is known to be problematic. In this paper, we present a methodology to determine a set of 'core classes' by using a range of techniques to reach consensus across several different clustering algorithms, and to ascertain the key characteristics of these classes. We apply the methodology to immunohistochemical data from breast cancer patients. In doing so, we identify six core classes, of which several may be novel sub-groups not previously emphasised in literature.
authors.affiliation: School of Computer Science, University of Nottingham, Jubilee Campus, Wollaton Road, Nottingham, UK.
authors.forename: Daniele
authors.initials: D
authors.lastname: Soria
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Garibaldi
authors.forename: Federico
authors.initials: F
authors.lastname: Ambrogi
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Green
authors.forename: Des
authors.initials: D
authors.lastname: Powe
authors.forename: Emad
authors.initials: E
authors.lastname: Rakha
authors.forename: R Douglas
authors.initials: RD
authors.lastname: Macmillan
authors.forename: Roger W
authors.initials: RW
authors.lastname: Blamey
authors.forename: Graham
authors.initials: G
authors.lastname: Ball
authors.forename: Paulo J G
authors.initials: PJ
authors.lastname: Lisboa
authors.forename: Terence A
authors.initials: TA
authors.lastname: Etchells
authors.forename: Patrizia
authors.initials: P
authors.lastname: Boracchi
authors.forename: Elia
authors.initials: E
authors.lastname: Biganzoli
authors.forename: Ian O
authors.initials: IO
authors.lastname: Ellis
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000378:metabolism*; D016000:Cluster Analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry