Pulse wave velocity is more closely associated with cardiovascular risk than augmentation index in the relatively low-risk population.
Pulse wave velocity (PWV) and augmentation index (AI) are both indirect indicators of arterial stiffness, which is an independent predictor of morbidity and mortality in cardiovascular diseases. The aim of this study was to assess the association between carotid AI (CAI), carotid-femoral PWV (CFPWV), and Framingham risk score (FRS), and to evaluate the factors determining CAI and CFPWV. Carotid AI and CFPWV were measured by applanation tonometry in 177 consecutive subjects without evidence of significant cardiovascular disease. Correlations between CAI and FRS and CFPWV and FRS were analyzed and major determinants of CAI and CFPWV were assessed. The mean age was 60.5 +/- 11.9 years and 112 (63%) of study patients were men. There was a significant association between CFPWV and FRS (r = 0.417, P < 0.001) and a weaker but also significant relation between CAI and FRS (r = 0.267, P < 0.001). CFPWV was significantly related to FRS in both men and women (P < 0.001 in both sexes), whereas the relation between CAI and FRS was significant only in women (P < 0.001). Our results suggest that CFPWV may be associated with CVD risk irrespective of sex, whereas CAI may be associated with CVD risk in women only.
Song
Bong Gun
BG
Division of Cardiology, Cardiac and Vascular Center, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, #50 Irwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea.
Park
Jeong Bae
JB
Cho
Soo Jin
SJ
Lee
Sang Yeub
SY
Kim
Jung Hyuk
JH
Choi
Seung Min
SM
Park
Ji Han
JH
Park
Yong Hwan
YH
Choi
Jin-Oh
JO
Lee
Sang-Chol
SC
Park
Seung Woo
SW
D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000503:physiopathology*; D002339:Carotid Arteries / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D004548:Elasticity; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology*; D006801:Humans; D016014:Linear Models; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011673:Pulsatile Flow; D018570:Risk Assessment; D012307:Risk Factors; D017678:Sex Distribution; D012737:Sex Factors