Elevated serum levels of S100 calcium binding protein A8 (S100A8) reflect disease severity in canine atopic dermatitis.
A monoclonal antibody to canine S100 calcium binding protein A8 (S100A8) was developed to determine the association between S100A8 and the disease severity of canine atopic dermatitis. Serum S100A8 concentrations were studied in dogs with canine atopic dermatitis (n=213) and healthy dogs (n=213). Statistical correlations between these indices and atopic dermatitis activity were established, and dermatitis severity was assessed according to the CADESI score. Serum S100A8 concentrations were measured with an enzyme-linked immunosorbent assay (ELISA). S100A8 serum levels were significantly higher in canine atopic dermatitis patients than in healthy dogs. A strong positive correlation was identified between S100A8 levels and canine atopic dermatitis patients. Our findings suggested that S100A8 is actively involved in the pathogenesis and clinical picture of canine atopic dermatitis.
Chung
Tae-Ho
TH
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Korea.
Oh
Jin-Sik
JS
Lee
Yong-Soon
YS
Kang
Kyung-Sun
KS
Jung
Ji-Won
JW
Youn
Hwa-Young
HY
Hwang
Cheol-Yong
CY
D000818:Animals; D000911:Antibodies, Monoclonal / Q000097:blood / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D040501:Calgranulin A / Q000097:blood* / Q000235:genetics / Q000276:immunology; D017931:DNA Primers; D003876:Dermatitis, Atopic / Q000097:blood / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D016133:Polymerase Chain Reaction; D012016:Reference Values; D012720:Severity of Illness Index
D000911:Antibodies, Monoclonal; D015415:Biomarkers; D040501:Calgranulin A; D017931:DNA Primers