title: One pot 'click' reactions: tandem enantioselective biocatalytic epoxide ring opening and [3+2] azide alkyne cycloaddition.
abstract: Halohydrin dehalogenase (HheC) can perform enantioselective azidolysis of aromatic epoxides to 1,2-azido alcohols which are subsequently ligated to alkynes producing chiral hydroxy triazoles in a one-pot procedure with excellent enantiomeric excess.
authors.affiliation: Stratingh Institute for Chemistry, University of Groningen, Groningen, the Netherlands.
authors.forename: Lachlan S
authors.initials: LS
authors.lastname: Campbell-Verduyn
authors.forename: Wiktor
authors.initials: W
authors.lastname: Szymański
authors.forename: Christiaan P
authors.initials: CP
authors.lastname: Postema
authors.forename: Rudi A
authors.initials: RA
authors.lastname: Dierckx
authors.forename: Philip H
authors.initials: PH
authors.lastname: Elsinga
authors.forename: Dick B
authors.initials: DB
authors.lastname: Janssen
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D055162:Biocatalysis; D004852:Epoxy Compounds / Q000737:chemistry*; D006867:Hydrolases / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D004852:Epoxy Compounds; D014230:Triazoles; D006867:Hydrolases; C430848:halohydrin dehalogenase