Targeting viral infection by microRNA inhibition.
An inhibitor of microRNA-122 reduces viral load in chimpanzees that are chronically infected with hepatitis C virus, suggesting that such an approach might have therapeutic potential in humans.
Roberts
Ashley P E
AP
School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Jopling
Catherine L
CL
D000818:Animals; D001706:Biopsy; D002986:Clinical Trials as Topic; D016174:Hepacivirus / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000821:virology*; D006801:Humans; D008099:Liver / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics*; D009841:Oligonucleotides / Q000235:genetics; D002679:Pan troglodytes
C531907:MIRN122 microRNA, human; D035683:MicroRNAs; D009841:Oligonucleotides