title: Cardiocirculatory changes in hemorrhagic shock induced in pigs submitted to three distinct therapeutic methods.
abstract: OBJECTIVE
  To evaluate and compare the response of pigs submitted to hemorrhagic shock and treated using three different strategies.
  
  
  METHODS
  Thirty-five Dalland pigs were divided into four groups: Control; Bleeding; Saline and Saline + Red Cell Concentrate. Parameters evaluated: heart rate (HR), mean arterial blood pressure (MAP) and central vein pressure (CVP).Hemorrhagic shock was induced by removing (624.25 + or - 64.55), (619.30 + or - 44.94) and (664.23 + or - 39.96) ml of blood respectively, with the following treatment: Bleeding Group - zero volume replacement; Saline Group - replacement with 676 ml of 0.9% saline solution; Saline + Red Cell Concentrate Group - replacement with 440 ml of 0.9% saline solution + 291 ml of red cell concentrate. The treatment was evaluated after 10 (T3), 30 (T4), 45 (T5) and 60 (T6) minutes.
  
  
  RESULTS
  HR: No statistically significant difference was found between the Bleeding and Saline [p=1.000], Bleeding and Saline + Red Cell Concentrate [p=1.000], and Saline and Saline + Red Cell Concentrate [p=0.721] groups. MAP; Significant differences were found between all the groups studied. CVP: No significant difference was found between the groups.
  
  
  CONCLUSIONS
  Non-replacement and euvolemic resuscitation maintained a satisfactory hemodynamic pattern in controlled severe hemorrhagic shock in swine. The euvolemic replacement strategies exceeded the limit values of MAP for rebleeding.
authors.affiliation: Department of Surgery, UFPE, Recife, PE, Brazil. gabreu01@uol.com.br
authors.forename: Gilberto Fernandes Silva de
authors.initials: GF
authors.lastname: Abreu
authors.forename: Antônio Roberto Barros
authors.initials: AR
authors.lastname: Coelho
authors.forename: José Lamartine de Andrade
authors.initials: JL
authors.lastname: Aguiar
authors.forename: Sílvio Amorim
authors.initials: SA
authors.lastname: Moura Filho
mesh_terms: D000818:Animals; D001802:Blood Substitutes / Q000494:pharmacology*; D004195:Disease Models, Animal; D005440:Fluid Therapy / Q000379:methods*; D006439:Hemodynamics / Q000187:drug effects*; D007552:Isotonic Solutions / Q000494:pharmacology*; D011897:Random Allocation; D012771:Shock, Hemorrhagic / Q000139:chemically induced / Q000188:drug therapy*; D013552:Swine
chemical_list: D001802:Blood Substitutes; D007552:Isotonic Solutions