title: Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments.
abstract: The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cells, therefore suggesting that ingestion is a viable route of uptake into different organism types. A consistency was also shown in the sensitivity of aquatic, fish cell and human cell models to Ag and CeO2 particles of different sizes; with the observed sensitivity sequence from highest to lowest as: nano-Ag > micro Ag > nano CeO2 = micro CeO2. Such consistency suggests that further studies might allow extrapolation of results between different models and species.
authors.affiliation: Edinburgh Napier University, UK.
authors.forename: Birgit K
authors.initials: BK
authors.lastname: Gaiser
authors.forename: Teresa F
authors.initials: TF
authors.lastname: Fernandes
authors.forename: Mark
authors.initials: M
authors.lastname: Jepson
authors.forename: Jamie R
authors.initials: JR
authors.lastname: Lead
authors.forename: Charles R
authors.initials: CR
authors.lastname: Tyler
authors.forename: Vicki
authors.initials: V
authors.lastname: Stone
mesh_terms: D000818:Animals; D002347:Carps / Q000378:metabolism; D002478:Cells, Cultured; D002563:Cerium / Q000378:metabolism / Q000633:toxicity*; D003621:Daphnia / Q000187:drug effects; D004435:Eating; D004781:Environmental Exposure / Q000032:analysis*; D004785:Environmental Pollutants / Q000378:metabolism / Q000633:toxicity*; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000378:metabolism; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D053768:Metal Nanoparticles / Q000633:toxicity*; D008954:Models, Biological; D010316:Particle Size; D012834:Silver / Q000378:metabolism / Q000633:toxicity*; D018675:Toxicity Tests
chemical_list: D004785:Environmental Pollutants; D002563:Cerium; D012834:Silver; C030583:ceric oxide