Hyperpolarized 89Y complexes as pH sensitive NMR probes.
Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T(1) decay of magnetization. Due to its long T(1), the hyperpolarized (89)Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the (89)Y chemical shift dependence upon pH for two hyperpolarized (89)Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH.
Jindal
Ashish K
AK
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
Merritt
Matthew E
ME
Suh
Eul Hyun
EH
Malloy
Craig R
CR
Sherry
A Dean
AD
Kovács
Zoltán
Z
D006863:Hydrogen-Ion Concentration; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D015335:Molecular Probes / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D015019:Yttrium / Q000737:chemistry*
D008024:Ligands; D015335:Molecular Probes; D009942:Organometallic Compounds; D015019:Yttrium