title: Towards building a chromosome segregation machine.
abstract: All organisms, from bacteria to humans, face the daunting task of replicating, packaging and segregating up to two metres (about 6 x 10(9) base pairs) of DNA when each cell divides. This task is carried out up to a trillion times during the development of a human from a single fertilized cell. The strategy by which DNA is replicated is now well understood. But when it comes to packaging and segregating a genome, the mechanisms are only beginning to be understood and are often as variable as the organisms in which they are studied.
authors.affiliation: Department of Biology, 622 Fordham Hall, CB3280, University of North Carolina at Chapel Hill, North Carolina 27599, USA. kerry_bloom@unc.edu
authors.forename: Kerry
authors.initials: K
authors.lastname: Bloom
authors.forename: Ajit
authors.initials: A
authors.lastname: Joglekar
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002455:Cell Division / Q000235:genetics; D002503:Centromere / Q000235:genetics; D002843:Chromatin / Q000378:metabolism; D020090:Chromosome Segregation / Q000235:genetics*; D004247:DNA / Q000737:chemistry; D005057:Eukaryotic Cells / Q000166:cytology* / Q000502:physiology; D006801:Humans; D011387:Prokaryotic Cells / Q000166:cytology* / Q000502:physiology; D021381:Protein Transport; D008941:Spindle Apparatus / Q000378:metabolism; D013816:Thermodynamics
chemical_list: D002843:Chromatin; D004247:DNA