title: [A case of acute lymphoblastic leukemia with variable appearance].
abstract: BACKGROUND
  A case of acute lymphoblastic leukemia in which a variety of ophthalmic findings were observed.
  
  
  METHODS
  A 27-year-old woman with acute lymphoblastic leukemia. Ocular findings were Roth's spot and serous retinal detachment. Fluorescein angiography revealed no clear leak point. Subsequently, the serous retinal detachment disappeared. Within 4 months after the initial diagnosis, cytomegalovirus (CMV) retinitis occurred, and further keratoconjunctivitis and serous retinal detachment recurred due to Graft-versus-Host Disease (GVHD), thus resulting in death 4 months later.
  
  
  CONCLUSIONS
  Cases in which patients with leukemia complicated by serous retinal detachment during the course often result in death. In the present case, CMV retinitis and keratoconjunctivitis occurred due to GVHD after serous retinal detachment, thus resulting in death 8 months after the initial diagnosis, therefore if serous retinal detachment is observed in a leukemia patient, it is necessary to perform periodical ophthalmologic examinations even after the ocular symptoms disappear.
authors.affiliation: Department of Ophthalmology, Hyogo College of Medicine, Hyogo-ken, Japan.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Yoshid
authors.forename: Norio
authors.initials: N
authors.lastname: Okamoto
authors.forename: Yuka
authors.initials: Y
authors.lastname: Hosotani
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Ueda
authors.forename: Katsuji
authors.initials: K
authors.lastname: Kaida
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Ogawa
authors.forename: Osamu
authors.initials: O
authors.lastname: Mimura
mesh_terms: D000328:Adult; D017726:Cytomegalovirus Retinitis / Q000209:etiology*; D005260:Female; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D012163:Retinal Detachment / Q000209:etiology*; D033581:Stem Cell Transplantation / Q000009:adverse effects