title: [Production of immunoregulatory cytokines in autoimimune damage of the ovaries in mammals].
abstract: Several ovarian disorders in women are associated with autoimmune factors. In this study it was investigated a level of cytokines--TNF-alpha and IFNs in ovarian homogenate and blood serum at ovarian autoimmune damage of mammals. Experimental immune ovarian failure was induced in CBA mice by either immunization with allogenic ovarian extracts or administration of xenogenic anti-ovarian antibodies. Both models were accompanied with abnormalities in production of immunoregulatory cytokines. These data confirm the importance of definition of proinflammatory cytokine level for disclosing immune mechanisms which lay in a pathogenesis autoimmune ovarian diseases of female reproductive organs.
authors.forename: R I
authors.initials: RI
authors.lastname: Ianchiĭ
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Voznesens'ka
authors.forename: O A
authors.initials: OA
authors.lastname: Shepel'
authors.forename: T M
authors.initials: TM
authors.lastname: Bryshina
authors.forename: V S
authors.initials: VS
authors.lastname: Sukhina
authors.forename: L M
authors.initials: LM
authors.lastname: Lazarenko
authors.forename: Z M
authors.initials: ZM
authors.lastname: Olevins'ka
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Spivak
authors.forename: R M
authors.initials: RM
authors.lastname: Serbeniuk
authors.forename: O M
authors.initials: OM
authors.lastname: Serdiuk
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000097:blood; D016207:Cytokines / Q000097:blood*; D004195:Disease Models, Animal; D005260:Female; D007372:Interferons / Q000097:blood; D051379:Mice; D008808:Mice, Inbred CBA; D010049:Ovarian Diseases / Q000097:blood / Q000276:immunology*; D010053:Ovary / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D007372:Interferons