Glioblastoma invasion, cathepsin B, and the potential for both to be inhibited by auranofin, an old anti-rheumatoid arthritis drug.
Kast
R E
RE
Psychiatry, University of Vermont, 22 Church Street, Burlington, VT 05401, USA. rekast@email.com
D018501:Antirheumatic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001310:Auranofin / Q000494:pharmacology* / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002401:Cathepsin B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005909:Glioblastoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009361:Neoplasm Invasiveness; D025101:Vitamin B 6 / Q000378:metabolism
D018501:Antirheumatic Agents; D001310:Auranofin; D025101:Vitamin B 6; D002401:Cathepsin B