title: [Correlation of the expression of survivin and caspase-3 proteins in juvenile laryngeal papilloma].
abstract: OBJECTIVE
  To investigate correlation between the expression of survivin and caspase-3 proteins in juvenile laryngeal papilloma.
  
  
  METHODS
  The expression of survivin and caspase-3 proteins were detected with immunohistochemical method in 43 cases of juvenile laryngeal papilloma, 25 vocal nodules and 25 normal laryngeal mucosa.
  
  
  RESULTS
  The positive rates of survivin protein in juvenile laryngeal papilloma were 57.14% and higher than that in vocal nodules (P<0.01) and the normal laryngeal mucosa (P<0.01). And the Caspase-3 protein positive rate was 26.19% in juvenile laryngeal papilloma and lower than that in vocal nodules and the normal laryngeal mucosa (P<0.01). There was a significant negative correlation between the expression of survivin and caspase-3 in juvenile laryngeal papilloma.
  
  
  CONCLUSIONS
  The abnormal expression of survivin and caspase-3 may play important role in the pathogenesis of juvenile laryngeal papilloma.
authors.affiliation: Children's Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Wang
authors.forename: Yuan-da
authors.initials: YD
authors.lastname: Zhou
authors.forename: Hai-xia
authors.initials: HX
authors.lastname: He
mesh_terms: D053148:Caspase 3 / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007223:Infant; D051034:Inhibitor of Apoptosis Proteins; D007822:Laryngeal Neoplasms / Q000235:genetics*; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D010212:Papilloma / Q000235:genetics*; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D000077022:Survivin; D053148:Caspase 3