title: Severe central nervous and respiratory system depression after sedation with chloral hydrate: a case report.
abstract: Chloral hydrate is generally considered a safe sedative-hypnotic drug, and is commonly used for sedation of infants and young children before diagnostic procedures. Even chloral hydrate administered within the recommended maximal dose limits can cause serious morbidity and mortality. Here the authors describe a four-month-old girl with a life-threatening central nervous system and respiratory depression after administration of a therapeutic dose of chloral hydrate. The patient gradually recovered with supportive treatment including ventilation therapy.
authors.affiliation: Department of Pediatrics, Adnan Menderes University Faculty of Medicine, Aydin, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Ceçen
authors.forename: Ozgün
authors.initials: O
authors.lastname: Uygur
authors.forename: Ayşe
authors.initials: A
authors.lastname: Tosun
mesh_terms: D002490:Central Nervous System / Q000187:drug effects*; D002697:Chloral Hydrate / Q000009:adverse effects*; D016292:Procedural Sedation; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D007223:Infant; D012131:Respiratory Insufficiency / Q000139:chemically induced*; D012720:Severity of Illness Index
chemical_list: D006993:Hypnotics and Sedatives; D002697:Chloral Hydrate