Effects of chitosan-coated pressed calcium sulfate pellets combined with recombinant human bone morphogenetic protein 2 on bone formation in femoral condyle-contained bone defects.
Calcium sulfate has a rapid degradation rate and little osteoinductive capability. Chitosan-coated pressed calcium sulfate pellets combined with recombinant human bone morphogenetic protein 2 (rhBMP-2) have been developed that exhibit decreased resorption speed and increased compressive strength and osteoinduction. A rabbit femoral condyle-contained bone defect model was used to study the restoration of the defects treated with chitosan-coated pressed calcium sulfate pellets combined with rhBMP-2, chitosan-coated pressed calcium sulfate pellets, and uncoated pressed calcium sulfate pellets. No pellets were implanted in the control group. After 3 and 13 weeks, the results indicated that chitosan-coated pressed calcium sulfate pellets exhibited relatively slower resorption that closely coincides with the growth rate of new bone and enhanced osteogenesis when combined with rhBMP-2.
Chen
Hua
H
Department of Orthopaedics, General Hospital of Chinese People's Liberation Army, Beijing, China.
Cui
Xu
X
Yu
XueZhong
X
Tian
XueZhong
X
Zhang
BoXun
B
Tang
PeiFu
P
Wang
Yan
Y
D000818:Animals; D015519:Bone Density; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D001862:Bone Resorption / Q000517:prevention & control; D002133:Calcium Sulfate / Q000494:pharmacology*; D048271:Chitosan / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible; D019245:Compressive Strength; D005269:Femur / Q000601:surgery; D006801:Humans; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D011817:Rabbits; D011897:Random Allocation; D011994:Recombinant Proteins / Q000494:pharmacology*; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D020099:Coated Materials, Biocompatible; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2; D048271:Chitosan; D002133:Calcium Sulfate