Antiplasmodial and cytotoxic activity of phloroglucinol derivatives from Hypericum erectum Thunb.
The chloroform extracts of whole plants of Hypericum erectum were investigated for antiplasmodial activity against chloroquine-sensitive strains of Plasmodium falciparum. Five phloroglucinol derivatives, otogirin (1), otogirone (2), erectquione A (3), erectquione B (4), and erectquione C (5) were isolated from the whole plants of H. erectum. Also, five compounds were evaluated for in vitro antiplasmodial activities as well as their cytotoxic potential on SK-OV-3 cancer cell line cells. Compounds 2, 4 showed notable growth inhibitory activity against chloroquine-sensitive strains of Plasmodium falciparum with IC(50) values from 5.6 and 7.2 microM. This compound showed no significant cytotoxicity (IC(50) > 150 microM) evaluated using SK-OV-3 cancer cell line cells.
Moon
Hyung-In
HI
Inam Neuroscience Research Center, Wonkwang University, Sanbon Medical Center, Kyunggi-Do, South Korea. himun68@gmail.com
D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010696:Phloroglucinol / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D010936:Plant Extracts; C454564:erectquione B; C454565:erectquione C; D010696:Phloroglucinol