title: Blumeaenes A-J, sesquiterpenoid esters from Blumea balsamifera with NO inhibitory activity.
abstract: Chemical examination of the ethanol extract of the aerial parts of Blumea balsamifera led to the isolation of ten new sesquiterpenoid esters, blumeaenes A-J (1- 10), with 13 known flavonoids. Their structures were determined mainly by use of 1D and 2D NMR spectroscopic techniques. All sesquiterpenoid esters were tested for their inhibitory activity against LPS-induced NO production in RAW264.7 macrophages. Compounds 1, 4 and 5 showed slight inhibitory effect on the production of NO with IC(50) values of 40.06, 46.35 and 57.80 microg/mL, respectively.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P R China.
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.forename: Jiang-Jiang
authors.initials: JJ
authors.lastname: Qin
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Fu
authors.forename: Xiao-Jia
authors.initials: XJ
authors.lastname: Hu
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Liu
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
authors.forename: Hui-Zi
authors.initials: HZ
authors.lastname: Jin
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D002460:Cell Line; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D008070:Lipopolysaccharides; D010936:Plant Extracts; D012717:Sesquiterpenes; D009569:Nitric Oxide