title: The effect of electroacupuncture on T cell responses in rats with experimental autoimmune encephalitis.
abstract: Successive electroacupuncture (EA) stimulation on Zusanli ST36 acupoints of rats with experimental autoimmune encephalitis (EAE), which is an inflammatory disease mediated by autoreactive T cells, relieved disease severity, inhibited specific T cell proliferation and rebuilt the CD4+ T cell subset balance. In addition, EA-treated rats had significantly higher ACTH concentrations in vivo compared to untreated EAE rats. These results indicated that EA stimulation could relieve the severity of EAE by restoring balance to the Th1/Th2/Th17/Treg Th cell subset responses by stimulating the hypothalamus to increase ACTH secretion.
authors.affiliation: Department of Neurobiology, Harbin Medical University, Heilongjiang Provincial Key Laboratory of Neurobiology, 157 Bao Jian Road, Harbin 150081, China.
authors.forename: Yu-mei
authors.initials: YM
authors.lastname: Liu
authors.forename: Xi-jun
authors.initials: XJ
authors.lastname: Liu
authors.forename: Sha-Sha
authors.initials: SS
authors.lastname: Bai
authors.forename: Li-li
authors.initials: LL
authors.lastname: Mu
authors.forename: Qing-fei
authors.initials: QF
authors.lastname: Kong
authors.forename: Bo
authors.initials: B
authors.lastname: Sun
authors.forename: Dan-dan
authors.initials: DD
authors.lastname: Wang
authors.forename: Jing-hua
authors.initials: JH
authors.lastname: Wang
authors.forename: Shi
authors.initials: S
authors.lastname: Shu
authors.forename: Guang-you
authors.initials: GY
authors.lastname: Wang
authors.forename: Hu-lun
authors.initials: HL
authors.lastname: Li
mesh_terms: D015669:Acupuncture Points; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism; D000818:Animals; D002452:Cell Count; D049109:Cell Proliferation; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D004195:Disease Models, Animal; D015671:Electroacupuncture / Q000379:methods*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D007031:Hypothalamus / Q000378:metabolism; D007108:Immune Tolerance / Q000502:physiology*; D007165:Immunosuppression Therapy / Q000379:methods*; D008213:Lymphocyte Activation / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D000324:Adrenocorticotropic Hormone