Outcomes of 1014 naturalistically treated inpatients with major depressive episode.
Due to strict exclusion criteria the generalizability of randomized controlled trials appears to be limited. Therefore, outcomes of naturalistically treated depressive inpatients with respect to depression mean scores, response and remission rates were evaluated. This was a multicenter trial, conducted in 12 psychiatric hospitals in Germany with a follow-up period of 4years. Patients were assessed biweekly from admission to discharge with diverse psychopathological rating scales. All patients (n=1014) met DSM-IV criteria for major depressive episode. Results are presented only for the acute inpatient treatment period. Mean inpatient treatment duration was 53.6+/-47.5days. Reduction on depression scales was evident as soon as week 2 and remained significant. Mean HAMD-17 total score decreased from 22.3 to 8.8. A total of 68.9% were classified as responders (> or =50% reduction of the initial HAMD-17 score), whereas 51.9% achieved remission (HAMD-17 total score < or =7). Of those who ultimately achieved response more than 40% did so within the first 2weeks. An individualized naturalistic inpatient treatment approach appears to be beneficial in terms of effectiveness.
Seemüller
Florian
F
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Germany. florian.seemueller@med.uni-muenchen.de
Riedel
Michael
M
Obermeier
Michael
M
Bauer
Michael
M
Adli
Mazda
M
Kronmüller
Klaus
K
Holsboer
Florian
F
Brieger
Peter
P
Laux
Gerd
G
Bender
Wolfram
W
Heuser
Isabella
I
Zeiler
Joachim
J
Gaebel
Wolfgang
W
Dichgans
Eva
E
Bottländer
Roland
R
Musil
Richard
R
Möller
Hans-Jürgen
HJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000628:therapy*; D004565:Electroconvulsive Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D010789:Phototherapy; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D012892:Sleep Deprivation; D050781:Transcranial Magnetic Stimulation; D016896:Treatment Outcome
D000928:Antidepressive Agents