title: Primary neuroendocrine carcinoma coexisting with hemangioma in the liver: report of a case.
abstract: Primary hepatic neuroendocrine carcinoma is an extremely rare liver tumor. We herein report a case of primary hepatic neuroendocrine carcinoma coexisting with a hemangioma in a 66-year-old man. Ultrasonography, computed tomography, and magnetic resonance imaging showed a tumor (1.5 cm in diameter) coexisting with a hemangioma in the lateral segment of the liver. Liver biopsy showed malignant cells, and several examinations revealed no alternative primary source. We performed a lateral segmentectomy. Microscopically, the tumor cells had round to oval nuclei and eosinophilic cytoplasm, proliferated in thick trabeculae or solid nests, and formed a focal rosette pattern. Mitotic cells were frequently observed. Immunohistochemically, the tumor cells were positive for the endocrine markers chromogranin A, neuron-specific enolase, and neural cell adhesion molecule, but negative for alpha-fetoprotein and hepatocyte-specific antigen. The patient is still alive after 3 months, without recurrence.
authors.affiliation: Department of Surgery, Beppu Medical Center, 1473 Oaza-Uchikamado, Beppu, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Akahoshi
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Higashi
authors.forename: Satoru
authors.initials: S
authors.lastname: Tsuruta
authors.forename: Kouichiro
authors.initials: K
authors.lastname: Tahara
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Hideya
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Shoichi
authors.initials: S
authors.lastname: Era
authors.forename: Fuminori
authors.initials: F
authors.lastname: Fujita
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Muto
mesh_terms: D018278:Carcinoma, Neuroendocrine / Q000000981:diagnostic imaging / Q000473:pathology*; D003937:Diagnosis, Differential; D006391:Hemangioma / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D016896:Treatment Outcome