Electrospun silk material systems for wound healing.
The functional properties of six distinct electrospun silk material groups were evaluated to assess conformational and biocompatible characteristics related to wound dressings. In a hydrated state, all six silk matrices exhibited absorption, water vapor transmission, oxygen permeation and enzymatic biodegradation suitable for full-thickness wound sites. Employing constrained drying techniques, silk concentration was a determinate factor influencing material structural properties related to the storage and distribution of such wound dressing systems. Subsequently, three electrospun silk models demonstrated ideal biomaterial properties with potential utility for wound dressings.
Wharram
Scott E
SE
Biomedical Engineering and Biotechnology, University of Massachusetts at Lowell, 1 University Avenue, Lowell, MA 01854, USA.
Zhang
Xiaohui
X
Kaplan
David L
DL
McCarthy
Stephen P
SP
D000042:Absorption / Q000187:drug effects; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D012831:Bombyx; D048271:Chitosan / Q000494:pharmacology; D008422:Materials Testing / Q000379:methods*; D018625:Microscopy, Atomic Force; D010100:Oxygen / Q000032:analysis; D016062:Porosity / Q000187:drug effects; D047011:Silk / Q000494:pharmacology* / Q000648:ultrastructure; D013499:Surface Properties / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
D001672:Biocompatible Materials; D047011:Silk; D048271:Chitosan; D010100:Oxygen