title: Successful use of therapeutic hypothermia in an opiate induced out-of-hospital cardiac arrest complicated by severe hypoglycaemia and amphetamine intoxication: a case report.
abstract: The survival to discharge rate after unwitnessed, non-cardiac out-of-hospital cardiac arrest (OHCA) is dismal. We report the successful use of therapeutic hypothermia in a 26-year old woman with OHCA due to intentional poisoning with heroin, amphetamine and insulin.The cardiac arrest was not witnessed, no bystander CPR was initiated, the time interval from the call to ambulance arrival was 9 minutes and the initial cardiac rhythm was asystole. Eight minutes of advanced cardiac life support resulted in ROSC.Upon hospital admission, the patient's pupils were dilated. Her arterial lactate was 17 mmol/l, base excess -20, pH 6.9 and serum glucose 0.2 mmol/l. During the first 24 hours in the ICU, the patient developed maximally dilated pupils not reacting to light and became increasingly haemodynamically unstable, requiring both inotropic support and massive fluid resuscitation. After 1 week in the ICU, however, she made an uneventful recovery with a Cerebral Performance Category of 1 at hospital discharge and at a follow up examination at 6 months.
  
  
  CONCLUSIONS
  According to most prognostic factors, the patient had a statistical chance for survival of less than 1%, not taking into account her severe state of hypoglyaemia. We suggest that this case exemplifies the need for more studies on the use of TH in non-coronary causes of OHCA.
authors.affiliation: Department of Anesthesia and Intensive Care Medicine, Stavanger University Hospital, Postboks 8100, 4068 Stavanger, Norway. Bumi@sus.no
authors.forename: Michael
authors.initials: M
authors.lastname: Busch
authors.forename: Eldar
authors.initials: E
authors.lastname: Søreide
mesh_terms: D000328:Adult; D000661:Amphetamine / Q000506:poisoning*; D001930:Brain Injuries / Q000517:prevention & control; D005260:Female; D006323:Heart Arrest / Q000097:blood / Q000139:chemically induced / Q000150:complications / Q000628:therapy*; D003932:Heroin / Q000506:poisoning*; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000150:complications*; D007036:Hypothermia, Induced; D007328:Insulin / Q000506:poisoning*; D011379:Prognosis
chemical_list: D007328:Insulin; D003932:Heroin; D000661:Amphetamine