title: Investigating the activity spectrum for ring-substituted 8-hydroxyquinolines.
abstract: In this study, a series of fourteen ring-substituted 8-hydroxyquinoline derivatives were prepared. The synthesis procedures are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four mycobacterial strains and against eight fungal strains. Several compounds showed biological activity comparable with or higher than the standards isoniazid or fluconazole. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed.
authors.affiliation: Institute of Chemistry, University of Silesia, Szkolna 9, 40007 Katowice, Poland. robert.musiol@us.edu.pl
authors.forename: Robert
authors.initials: R
authors.lastname: Musiol
authors.forename: Josef
authors.initials: J
authors.lastname: Jampilek
authors.forename: Jacek E
authors.initials: JE
authors.lastname: Nycz
authors.forename: Matus
authors.initials: M
authors.lastname: Pesko
authors.forename: James
authors.initials: J
authors.lastname: Carroll
authors.forename: Katarina
authors.initials: K
authors.lastname: Kralova
authors.forename: Marcela
authors.initials: M
authors.lastname: Vejsova
authors.forename: Jim
authors.initials: J
authors.lastname: O'Mahony
authors.forename: Aidan
authors.initials: A
authors.lastname: Coffey
authors.forename: Anna
authors.initials: A
authors.lastname: Mrozek
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Polanski
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002736:Chloroplasts / Q000187:drug effects / Q000378:metabolism; D004579:Electron Transport / Q000187:drug effects; D006912:Hydroxyquinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects; D010788:Photosynthesis / Q000187:drug effects; D018724:Spinacia oleracea / Q000187:drug effects / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D006912:Hydroxyquinolines