Supercapacitive transport of pharmacologic agents using nanoporous gold electrodes.
In this study, nanoporous gold supercapacitors were produced by electrochemical dealloying of gold-silver alloy. Scanning electron microscopy and energy dispersive X-ray spectroscopy confirmed completion of the dealloying process and generation of a porous gold material with approximately 10 nm diameter pores. Cyclic voltammetry and chronoamperometry of the nanoporous gold electrodes indicated that these materials exhibited supercapacitor behavior. The storage capacity of the electrodes measured by chronoamperometry was approximately 3 mC at 200 mV. Electrochemical storage and voltage-controlled delivery of two model pharmacologic agents, benzylammonium and salicylic acid, was demonstrated. These results suggest that capacitance-based storage and delivery of pharmacologic agents may serve as an alternative to conventional drug delivery methods.
Gittard
Shaun D
SD
Joint Department of Biomedical Engineering, University of North Carolina Chapel Hill and North Carolina State University, Raleigh, NC, USA.
Pierson
Bonnie E
BE
Ha
Cindy M
CM
Wu
Chung-An Max
CA
Narayan
Roger J
RJ
Robinson
David B
DB
D050339:Benzylammonium Compounds / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D025802:Electric Capacitance; D004566:Electrodes; D006046:Gold / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D016062:Porosity; D012459:Salicylates / Q000737:chemistry; D012834:Silver / Q000737:chemistry*
D050339:Benzylammonium Compounds; D012459:Salicylates; D012834:Silver; D006046:Gold