Markedly different cytotoxicity of the two enantiomers of C(2)-symmetrical Ti(IV) phenolato complexes; mechanistic implications.
The two enantiomers of a member of the highly active C(2)-symmetrical bis(isopropoxo) Ti(iv) family of complexes of diamine bis(phenolato) ligands demonstrate markedly different cytotoxicity, supporting a chiral biological target of activity and participation of a ligand-bound active species.
Manna
Cesar M
CM
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Tshuva
Edit Y
EY
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D018360:Crystallography, X-Ray; D003959:Diamines / Q000737:chemistry; D019073:HT29 Cells; D006801:Humans; D008968:Molecular Conformation; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
D000970:Antineoplastic Agents; D056831:Coordination Complexes; D003959:Diamines; D014025:Titanium