title: The associations of hA3G and hA3B mRNA levels with HIV disease progression among HIV-infected individuals of China.
abstract: OBJECTIVE
  To explore correlations between mRNA (hA3G, hA3F, and hA3B) levels and CD4 T-cell counts and HIV-1 viral loads to evaluate their respective roles in disease progression.
  
  
  METHODS
  Real-time polymerase chain reaction was used to quantify the mRNA levels of hA3G, hA3B, and hA3F in peripheral blood mononuclear cells from slow progress patients (SP), asymptomatic HIV-infected patients (AS), AIDS patients, and HIV-negative controls.
  
  
  RESULTS
  The levels of hA3G and hA3B mRNA correlated positively with CD4 T-cell counts (r = 0.436, P = 0.002, r = 0.334, P = 0.025), and negatively with HIV-1 viral loads (r = -0.306, P = 0.038, r = -0.301 P = 0.044). The levels of hA3G and hA3B mRNA in HIV-infected subjects were lower than in HIV-negative controls (P < 0.05), and hA3G and hA3B mRNA levels were significantly higher in SP than in AIDS patients (P < 0.05). There was no correlation between the hA3F mRNA level and CD4 T-cell counts or between the hA3F mRNA level and HIV-1 viral loads.
  
  
  CONCLUSIONS
  Higher expression levels of hA3G and hA3B mRNA in the peripheral blood mononuclear cells of Chinese HIV-infected individuals were found to be associated with slower HIV disease progression, suggesting their potential roles in antiviral innate immunity.
authors.affiliation: The First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.forename: Wenqing
authors.initials: W
authors.lastname: Geng
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Jiang
authors.forename: Xiaoxu
authors.initials: X
authors.lastname: Han
authors.forename: Hualu
authors.initials: H
authors.lastname: Cui
authors.forename: Di
authors.initials: D
authors.lastname: Dai
authors.forename: Mingjia
authors.initials: M
authors.lastname: Bao
authors.forename: Ying
authors.initials: Y
authors.lastname: Pan
authors.forename: Yating
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Zhang
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Guan
authors.initials: G
authors.lastname: Qi
authors.forename: Hong
authors.initials: H
authors.lastname: Shang
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D018450:Disease Progression; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000502:physiology; D014644:Genetic Variation; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy / Q000821:virology; D006801:Humans; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D012333:RNA, Messenger