title: Outcomes of renal transplants from spousal donors: 25 years of experience at our center.
abstract: OBJECTIVE
  Many transplantation teams have attempted renal transplants from living unrelated kidney donors, as well as from cadaveric and living related kidney donors. In this study, we evaluated the results for renal transplants from spousal donors at our center.
  
  
  METHODS
  We retrospectively analyzed renal transplant patients from spousal donors from 1983 to 2008. A total of 25 patients who underwent a cadaveric donor renal transplant from 1983 to 2008 were also studied as a control group. Patients were evaluated regarding patient and graft survival at 1 and 5 years of follow-up. Acute rejection, delayed graft function, infections, and late complications were recorded.
  
  
  RESULTS
  Thirty-eight male, spousal transplant recipients (group 1), 21 female, spousal transplant recipients (group 2), and 25 cadaveric donor transplant recipients were included this study. Graft survival rates were 96% in group 1 and 100% in group 2 (p=0.76) at 1-year follow-up. Patient survival rates in group 1 and 2 were both 100% at 1-year follow-up. Graft survival rates were 80% in group 1 and 100% in group 2 (p=0.12) at 5-year follow-up. Patient survival rates were 90% in group 1 and 100% in group 2 (p=0.56) at 5-year follow-up. Acute rejection rates were 10% (group 1) and 33% (group 2) (p=0.03); delayed graft function rates were 0% (group 1) and 10% (group 2) (p=0.05); infection rates were 16% (group 1) and 5% (group 2) (p=0.21) as early period posttransplant complications.
  
  
  CONCLUSIONS
  Results for transplants between spouses in our groups were comparable to those previously reported in the literature. Acute rejection rates were mildly higher in female recipients than in the male recipients due to pre-sensitization arising from previous pregnancies; however long-term patient and graft survival rates were not significantly different between female and male recipients.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. numangorgulu@gmail.com
authors.forename: Numan
authors.initials: N
authors.lastname: Gorgulu
authors.forename: Yasar
authors.initials: Y
authors.lastname: Caliskan
authors.forename: Berna
authors.initials: B
authors.lastname: Yelken
authors.forename: Aydin
authors.initials: A
authors.lastname: Turkmen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000276:immunology / Q000401:mortality* / Q000601:surgery*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors; D018454:Spouses; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult