title: Fifteen-piconewton force detection from neural growth cones using nanowire arrays.
abstract: We used epitaxially grown monodisperse nanowire arrays to measure cellular forces with a spatial resolution of 1 mum. Nerve cells were cultured on the array and cellular forces were calculated from the displacement of the nanowire tips. The measurements were done in situ on live cells using confocal microscopy. Forces down to 15 pN were measured on neural growth cones, showing that this method can be used to study the fine details of growth-cone dynamics.
authors.affiliation: Division of Solid State Physics, Lund University, Sweden.
authors.forename: Waldemar
authors.initials: W
authors.lastname: Hällström
authors.forename: Monica
authors.initials: M
authors.lastname: Lexholm
authors.forename: Dmitry B
authors.initials: DB
authors.lastname: Suyatin
authors.forename: Greger
authors.initials: G
authors.lastname: Hammarin
authors.forename: Dan
authors.initials: D
authors.lastname: Hessman
authors.forename: Lars
authors.initials: L
authors.lastname: Samuelson
authors.forename: Lars
authors.initials: L
authors.lastname: Montelius
authors.forename: Martin
authors.initials: M
authors.lastname: Kanje
authors.forename: Christelle N
authors.initials: CN
authors.lastname: Prinz
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004867:Equipment Design; D019544:Equipment Failure Analysis; D020439:Growth Cones / Q000502:physiology* / Q000648:ultrastructure*; D051379:Mice; D046228:Microarray Analysis / Q000295:instrumentation*; D036103:Nanotechnology / Q000295:instrumentation*; D043942:Nanotubes / Q000737:chemistry*; D013314:Stress, Mechanical; D014159:Transducers