title: Conformality study for stereotactic radiosurgery of the lung.
abstract: The purpose of this study is to compare two techniques of developing highly conformal plans for stereotactic body radiation therapy (SBRT) that target a high ablative dose to the center of the tumor while dropping off rapidly in normal tissues to determine which technique produced a more desirable treatment plan. The techniques used for comparison are "field in field" (FIF) and "non field in field" (NFIF). Twelve case studies were used, all of which had been treated using the FIF technique. Each FIF plan was edited, maintaining the same geometry for each field but reducing the total number of fields to one half by deleting all of the fields that were inside another field; this edited plan was the NFIF plan. Normalization was made to the isodose line (NFIF-I) and to the target volume (NFIF-V) and both plans were compared with the standard FIF plan independently. Dose-ratio comparisons were made of the 80% and 50% isodose volumes, as well as maximum doses outside of the planning target volume, mean dose to the gross tumor volume (GTV), minimum dose coverage on the GTV, maximum dose to the spinal cord, and the dose to the volume of noninvolved lung receiving 2000 cGy (V20). The FIF plans resulted in the best sparing of normal tissue. The NFIF-I had the best target coverage but also resulted in the highest doses to normal tissues. The NFIF-V was not significantly different from the FIF in doses to normal tissue but had the lowest coverage to targets of any of the techniques. Overall, in our department, we have chosen to use the FIF technique for SBRT conformality to obtain optimal coverage while minimizing the dose to normal tissue.
authors.affiliation: Department of Radiation Oncology, IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA. mewing@clarian.org
authors.forename: Marvene M
authors.initials: MM
authors.lastname: Ewing
authors.forename: Colleen
authors.initials: C
authors.lastname: Desrosiers
authors.forename: Achilles J
authors.initials: AJ
authors.lastname: Fakiris
authors.forename: Carolyn R
authors.initials: CR
authors.lastname: DeBliek
authors.forename: Daniel N
authors.initials: DN
authors.lastname: Kiszka
authors.forename: Eric R
authors.initials: ER
authors.lastname: Stinson
authors.forename: Lanice E
authors.initials: LE
authors.lastname: Young
authors.forename: Gregory K
authors.initials: GK
authors.lastname: Bartlett
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery*; D008954:Models, Biological; D011835:Radiation Protection / Q000379:methods*; D011874:Radiometry / Q000379:methods*; D016634:Radiosurgery / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*