title: Quantum-dot-based immunofluorescent imaging of HER2 and ER provides new insights into breast cancer heterogeneity.
abstract: Breast cancer (BC) is a heterogeneous tumor, and better understanding of its heterogeneity is essential to improving treatment effect. Quantum dot (QD)-based immunofluorescent nanotechnology (QD-IHC) for molecular pathology has potential advantages in delineating tumor heterogeneity. This potential is explored in this paper by QD-IHC imaging of HER2 and ER. BC heterogeneity can be displayed more clearly and sensitively by QD-IHC than conventional IHC in BC tissue microarrays. Furthermore, the simultaneous imaging of ER and HER2 might help understand their interactions during the process of evolution of heterogeneous BC.
authors.affiliation: Department of Oncology, Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan, People's Republic of China.
authors.forename: Chuang
authors.initials: C
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Peng
authors.forename: Heshun
authors.initials: H
authors.lastname: Xia
authors.forename: Qiongshui
authors.initials: Q
authors.lastname: Wu
authors.forename: Libo
authors.initials: L
authors.lastname: Zeng
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
authors.forename: Hongwu
authors.initials: H
authors.lastname: Tang
authors.forename: Zhiling
authors.initials: Z
authors.lastname: Zhang
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhu
authors.forename: Daiwen
authors.initials: D
authors.lastname: Pang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism*; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D005455:Fluorescent Antibody Technique / Q000379:methods*; D018740:Genetic Heterogeneity; D006801:Humans; D008875:Middle Aged; D045663:Quantum Dots; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D046888:Tissue Array Analysis
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; C508053:ERBB2 protein, human