FineStr: a web server for single-base-resolution nucleosome positioning.
CONCLUSIONS
The DNA in eukaryotic cells is packed into the chromatin that is composed of nucleosomes. Positioning of the nucleosome core particles on the sequence is a problem of great interest because of the role nucleosomes play in different cellular processes including gene regulation. Using the sequence structure of 10.4 base DNA repeat presented in our previous works and nucleosome core DNA sequences database, we have derived the complete nucleosome DNA bendability matrix of Caenorhabditis elegans. We have developed a web server named FineStr that allows users to upload genomic sequences in FASTA format and to perform a single-base-resolution nucleosome mapping on them.


BACKGROUND
FineStr server is freely available for use on the web at http:/www.cs.bgu.ac.il/ approximately nucleom. The site contains a help file with explanation regarding the exact usage.


BACKGROUND
gabdank@cs.bgu.ac.il.
Gabdank
Idan
I
Department of Computer Science, Ben Gurion University of the Negev, Beer Sheva 84105, Israel. gabdank@cs.bgu.ac.il
Barash
Danny
D
Trifonov
Edward N
EN
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D002843:Chromatin / Q000378:metabolism; D020407:Internet; D009707:Nucleosomes / Q000737:chemistry*; D017422:Sequence Analysis, DNA; D012984:Software
D002843:Chromatin; D009707:Nucleosomes