title: On a new strategy of preventive oncology.
abstract: The etiology of cancer is much wider than separately taken causal agent and rests against the most complicated interrelation and mutuality of many external and internal influences. Our researches with use of fluorescing antibodies to AFP, CEA and Ca-19-9 have shown that they are intensively besieged on a surface of cultivated malignant cells. It is the basic mechanism of tolerance and immunological escape, which is similar to pregnancy when "the maximal immunological most favored status" to developing fetus (semiallogenic transplant) is provided. The earliest revealing of first cancer cells, before steady community of cells and tumor angiogenesis were formed, has particular importance in the fight against cancer. The necessity of the specific completion of the weakened antineoplastic resistibility of people from high oncological risk groups is substantiated. The activity in this direction brought forth the design of embryonic anti-tumor modulator (EATM). EATM is composed of a wide pool of fetal proteins and proteoglycans isolated exceptionally from normal embryonic substances.
authors.affiliation: Russian-Armenian Scientific Medical Center, Yerevan, Armenia. MLN-38@mail.ru
authors.forename: L N
authors.initials: LN
authors.lastname: Mkrtchyan
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use / Q000633:toxicity; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D018394:CA-125 Antigen / Q000627:therapeutic use / Q000633:toxicity; D018395:CA-19-9 Antigen / Q000627:therapeutic use / Q000633:toxicity; D006063:Chorionic Gonadotropin / Q000627:therapeutic use / Q000633:toxicity; D005326:Fetal Proteins / Q000627:therapeutic use* / Q000633:toxicity; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000517:prevention & control; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D018675:Toxicity Tests; D000509:alpha-Fetoproteins / Q000627:therapeutic use / Q000633:toxicity
chemical_list: D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D006063:Chorionic Gonadotropin; D005326:Fetal Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins; D000509:alpha-Fetoproteins