title: Free radicals in primary knee osteoarthritis.
abstract: Free radicals have an important role in the pathogenesis of knee osteoarthritis. Reactive oxygen species (ROS) produced by abnormal chondrocyte metabolism exceeds the physiological buffering capacity and results in oxidative stress. The excessive production of ROS can damage proteins, lipids, nucleic acids, and matrix components. They also serve as important intracellular signaling molecules that amplify the inflammatory response. An understanding of oxidative stress involved in this disease might allow the use of antioxidant therapies in the prevention and/or treatment of knee osteoarthritis.
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. tewsv@mahidol.ac.th
authors.forename: Werasak
authors.initials: W
authors.lastname: Sutipornpalangkul
authors.forename: Noppawan Phumala
authors.initials: NP
authors.lastname: Morales
authors.forename: Thossart
authors.initials: T
authors.lastname: Harnroongroj
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D019902:Chondrocytes / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D020370:Osteoarthritis, Knee / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000975:Antioxidants; D016326:Extracellular Matrix Proteins; D005609:Free Radicals; D017382:Reactive Oxygen Species