Note: Interference technique for minimally invasive, subnanometer, microsecond measurements of displacements.
We present a novel high-resolution technique for single-molecule experiments, viz., differential traveling wave tracking. This is an interference-based scattering technique where we use gold nanoparticles for high scattering intensities and incorporate differential measurements along one in-plane direction to subtract mechanical noise and drift of the system. In addition, out-of-plane distances are measured via scattered light intensity in a total internal reflectance illumination field. In plane, we demonstrate a rms noise level of only 0.10 nm at 10 kHz and less than 0.5 nm at 600 kHz.
Dujovne
Irene
I
Kavli Institute of NanoScience, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands.
Kerssemakers
Jacob
J
Cappello
G
G
Dekker
Cees
C
D004247:DNA / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D008027:Light; D008029:Lighting; D053768:Metal Nanoparticles / Q000737:chemistry; D009038:Motion; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D012542:Scattering, Radiation; D013997:Time Factors
D006046:Gold; D004247:DNA