title: Indigenous use and bio-efficacy of medicinal plants in the Rasuwa District, Central Nepal.
abstract: BACKGROUND
  By revealing historical and present plant use, ethnobotany contributes to drug discovery and socioeconomic development. Nepal is a natural storehouse of medicinal plants. Although several ethnobotanical studies were conducted in the country, many areas remain unexplored. Furthermore, few studies have compared indigenous plant use with reported phytochemical and pharmacological properties.
  
  
  METHODS
  Ethnopharmacological data was collected in the Rasuwa district of Central Nepal by conducting interviews and focus group discussions with local people. The informant consensus factor (FIC) was calculated in order to estimate use variability of medicinal plants. Bio-efficacy was assessed by comparing indigenous plant use with phytochemical and pharmacological properties determined from a review of the available literature. Criteria were used to identify high priority medicinal plant species.
  
  
  RESULTS
  A total of 60 medicinal formulations from 56 plant species were documented. Medicinal plants were used to treat various diseases and disorders, with the highest number of species being used for gastro-intestinal problems, followed by fever and headache. Herbs were the primary source of medicinal plants (57% of the species), followed by trees (23%). The average FIC value for all ailment categories was 0.82, indicating a high level of informant agreement compared to similar studies conducted elsewhere. High FIC values were obtained for ophthalmological problems, tooth ache, kidney problems, and menstrual disorders, indicating that the species traditionally used to treat these ailments are worth searching for bioactive compounds: Astilbe rivularis, Berberis asiatica, Hippophae salicifolia, Juniperus recurva, and Swertia multicaulis. A 90% correspondence was found between local plant use and reported plant chemical composition and pharmacological properties for the 30 species for which information was available. Sixteen medicinal plants were ranked as priority species, 13 of which having also been prioritized in a country-wide governmental classification.
  
  
  CONCLUSIONS
  The Tamang people possess rich ethnopharmacological knowledge. This study allowed to identify many high value and high priority medicinal plant species, indicating high potential for economic development through sustainable collection and trade.
authors.affiliation: Human Ecology Department, Vrije Universiteit Brussel, Laarbeeklaan 109, B-1090 Brussels, Belgium. Yadav.Uprety@uqat.ca
authors.forename: Yadav
authors.initials: Y
authors.lastname: Uprety
authors.forename: Hugo
authors.initials: H
authors.lastname: Asselin
authors.forename: Emmanuel K
authors.initials: EK
authors.lastname: Boon
authors.forename: Saroj
authors.initials: S
authors.lastname: Yadav
authors.forename: Krishna K
authors.initials: KK
authors.lastname: Shrestha
mesh_terms: D019448:Ethnobotany; D020834:Ethnopharmacology; D017144:Focus Groups; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007407:Interviews as Topic; D019684:Magnoliopsida; D009390:Nepal; D008517:Phytotherapy; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D044382:Population Groups
chemical_list: D028321:Plant Preparations