[Intercellular reabsorption in the general systemic absorption of ethanol in the gastrointestinal tract].
Using the model of different ethanol concentration gradient between gastrointestinal tract (GIT) and blood of white mice, we analyzed kinetics of the intercellular transport of original compound and its metabolites (radioactive material). We showed that with intravenous administration 14C-ethanol (5 mmol/kg), its penetration into various divisions ofGIT (stomach, thin, thick, rectum) was observed. Creating a concentration gradient of ethanol by intravenous injection of ethanol (5 mmol/kg) and peroral intake (5, 10, 20 mmol/kg) led to a reduction in its intake into GIT, which was not entirely restricted under the laws of diffusion. Possible mechanisms for this phenomenon (insufficient gradient of ethanol concentrations in the blood-GIT, intrahepatic circulation, the residual radioactivity in the capillaries) are under discussion. The conclusion was made on possible reabsorption of ethanol in the process of its absorption in GIT.
Holovenko
M Ia
MIa
Borysiuk
I Iu
IIu
Likhota
O B
OB
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D001692:Biological Transport; D002250:Carbon Radioisotopes; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D041981:Gastrointestinal Tract / Q000378:metabolism*; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D000431:Ethanol