Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups.
A continuous flow system for the synthesis of enantioenriched diarylmethanols from aldehydes is described. The system uses an amino alcohol-functionalized polystyrene resin as the catalyst, and the arylating agent is conveniently prepared by transmetallation of triarylboroxins with diethylzinc.
Rolland
Julien
J
Institute of Chemical Research of Catalonia, Avinguda Països Catalans, Tarragona, Spain.
Cambeiro
Xacobe C
XC
Rodríguez-Escrich
Carles
C
Pericàs
Miquel A
MA