title: Prevalence of vertebral fracture in postmenopausal women with lumbar osteopenia using MorphoXpress® (OSTEOXPRESS Study).
abstract: OBJECTIVE
  Vertebral fracture (VF) is the most common complication of osteoporosis. However, more than half of all VF are asymptomatic and may go unnoticed, even in patients with osteoporosis. Our aim was to assess the prevalence of VF in postmenopausal women with osteopenic lumbar densitometry by means of vertebral morphometry, using the MorphoXpress® software.
  
  
  METHODS
  This was an epidemiological, cross-sectional, multicenter study conducted among 289 postmenopausal women (>1 year of amenorrhoea), diagnosed with lumbar osteopenia (not due to chronic treatment with corticosteroids or immobilization). Vertebral deformities ≥20% were considered as VF.
  
  
  RESULTS
  Demographic and clinical characteristics showed mean age (±SD) 64±9 years, body mass index 27±5 kg/m2, and time from diagnosis of 2±3 years. A total of 25% of subjects had a family history of osteoporotic fracture in first-degree relatives, and 23% had previous fragility fracture. The prevalence of VF was 50% (CI 95% 44-56), the most frequent being the dorsal wedge (34%). Previous fragility fracture was a risk factor for VF (OR 3.13, p=0.0004). A total of 76.5% of patients were receiving treatment, mainly calcium and vitamin D supplements (70%) and bisphosphonates (27%).
  
  
  CONCLUSIONS
  MorphoXpress® revealed that 50% of postmenopausal women with osteopenic lumbar densitometry showed VF. This result is important since only 7% of all evaluated subjects had previously been diagnosed with VF.
authors.affiliation: Rheumatology Department, Hospital San Agustín, C/Camino de Heros 4C, 33400 Avilés, Asturias, Spain. arboleya@ser.es
authors.forename: Luis
authors.initials: L
authors.lastname: Arboleya
authors.forename: Manuel
authors.initials: M
authors.lastname: Díaz-Curiel
authors.forename: Luis
authors.initials: L
authors.lastname: Del Río
authors.forename: Josep
authors.initials: J
authors.lastname: Blanch
authors.forename: Adolfo
authors.initials: A
authors.lastname: Díez-Pérez
authors.forename: Nuria
authors.initials: N
authors.lastname: Guañabens
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Quesada
authors.forename: Manuel
authors.initials: M
authors.lastname: Sosa
authors.forename: Carlos
authors.initials: C
authors.lastname: Gómez
authors.forename: Manuel
authors.initials: M
authors.lastname: Muñoz-Torres
authors.forename: Esther
authors.initials: E
authors.lastname: Ramírez
authors.forename: Josep
authors.initials: J
authors.lastname: Combalia
mesh_terms: D000368:Aged; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000150:complications*; D003430:Cross-Sectional Studies; D003720:Densitometry; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae; D008875:Middle Aged; D017698:Postmenopause; D015995:Prevalence; D012984:Software; D016103:Spinal Fractures / Q000453:epidemiology* / Q000209:etiology