Amyloid light chain deposition associated with dermatofibroma: serendipity or association?
Primary cutaneous amyloidosis, also known as nodular amyloidosis, is defined as deposition of amyloid light chain in the skin in the absence of a systemic cause of amyloidosis. Such amyloid is produced by a localized aggregate of clonal plasma cells. In contrast, secondary cutaneous amyloidosis is related to lesions such as squamous cell carcinoma, Bowen disease, basal cell carcinoma, and discoid lupus erythematosus, and has been shown in most cases to be derived from keratin epithelial elements. Herein, we present a unique case of nodular amyloidosis occurring in association with a cellular dermatofibroma.
Quigley
Brian C
BC
From the *Department of Pathology, University of South Florida, College of Medicine, Tampa, FL; †University of Florida, Gainesville, FL; ‡Department of Dermatology, University of Florida College of Medicine, Gainesville, FL; and §Dermatopathology, James A. Haley VA Hospital, Tampa, FL.
Ricciuti
Jason
J
Morgan
Michael B
MB
D000682:Amyloid / Q000032:analysis / Q000378:metabolism*; D003937:Diagnosis, Differential; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000378:metabolism*; D008067:Lipoma / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
D000682:Amyloid; D007147:Immunoglobulin Light Chains