Periodontal regeneration: focus on growth and differentiation factors.
Several growth and differentiation factors have shown potential as therapeutic agents to support periodontal wound healing/regeneration, although optimal dosage, release kinetics, and suitable delivery systems are still unknown. Experimental variables, including delivery systems, dose, and the common use of poorly characterized preclinical models, make it difficult to discern the genuine efficacy of each of these factors. Only a few growth and differentiation factors have reached clinical evaluation. It appears that well-defined discriminating preclinical models followed by well-designed clinical trials are needed to further investigate the true potential of these and other candidate factors. Thus, current research is focused on finding relevant growth and differentiation factors, optimal dosages, and the best approaches for delivery to develop clinically meaningful therapies in patient-centered settings.
Lee
Jaebum
J
Laboratory for Applied Periodontal & Craniofacial Regeneration (LAPCR), Departments of Periodontics and Oral Biology, Medical College of Georgia School of Dentistry, 1120 5th Street AD1434, Augusta, GA 30912, USA.
Stavropoulos
Andreas
A
Susin
Cristiano
C
Wikesjö
Ulf M E
UM
D016301:Alveolar Bone Loss / Q000188:drug therapy*; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology* / Q000627:therapeutic use; D001861:Bone Regeneration / Q000187:drug effects; D003739:Dental Cementum / Q000187:drug effects; D004285:Dogs; D017823:Furcation Defects / Q000188:drug therapy; D055412:Growth Differentiation Factors / Q000494:pharmacology* / Q000627:therapeutic use; D006133:Growth Substances / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008252:Macaca fascicularis; D017622:Periodontal Attachment Loss / Q000188:drug therapy*; D012038:Regeneration / Q000187:drug effects*
D019485:Bone Morphogenetic Proteins; D055412:Growth Differentiation Factors; D006133:Growth Substances