Selective generation of quaternary all-carbon-centres through Heck-cyclisations: synthesis of mesembrane.
Described is an observation that the intramolecular Heck reaction of a trisubstituted alkene proceeds with high regioselectivity and leads to the preferential formation of a quaternary all-carbon-centre. This observation was subsequently applied in a short synthesis of (+/-)-mesembrane.
Klein
Johannes E M N
JE
Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Dublin 4, Ireland.
Geoghegan
Kimberly
K
Méral
Nicolas
N
Evans
Paul
P