title: Biodistribution of technetium-99m pertechnetate after Roux-en-Y gastric bypass (Capella technique) in rats.
abstract: OBJECTIVE
  The biodistribution of sodium pertechnetate, the most used radiopharmaceutical in nuclear medicine, has not been studied in details after bariatric surgery. The objective was to investigate the effect of Roux-en-Y gastric bypass (RYGB) on biodistribution of sodium pertechnetate (Na(99m)Tc(-)) in organs and tissues of rats.
  
  
  METHODS
  Twelve rats were randomly divided into two groups of 6 animals each. The RYGB group rats were submitted to the Roux-en-Y gastric bypass and the control group rats were not operated. After 15 days, all rats were injected with 0.1 mL of Na(99m)Tc(-) via orbital plexus with average radioactivity of 0.66 MBq. After 30 minutes, liver, stomach, thyroid, heart, lung, kidney and femur samples were harvested, weighed and percentage of radioactivity per gram (%ATI/g) of each organ was determined by gama counter Wizard Perkin-Elmer. We applied the Student t test for statistical analysis, considering p<0.05 as significant.
  
  
  RESULTS
  Significant reduction in mean %ATI/g was observed in the liver, stomach and femur in the RYGB group animals, compared with the control group rats (p<0.05). In other organs no significant difference in %ATI/g was observed between the two groups.
  
  
  CONCLUSIONS
  This work contributes to the knowledge that the bariatric surgery RYGB modifies the pattern of biodistribution of Na(99m)Tc(-).
authors.affiliation: Department of Surgery, School of Medicine, Federal University of Rio Grande do Norte (UFRN), Natal, Brazil.
authors.forename: Amália Cínthia Meneses do
authors.initials: AC
authors.lastname: Rêgo
authors.forename: Irami
authors.initials: I
authors.lastname: Araújo-Filho
authors.forename: Italo Medeiros
authors.initials: IM
authors.lastname: Azevedo
authors.forename: Daniel Tôrres
authors.initials: DT
authors.lastname: Jácome
authors.forename: Rachel de Alcântara Oliveira
authors.initials: Rde A
authors.lastname: Ramalho
authors.forename: Aldo Cunha
authors.initials: AC
authors.lastname: Medeiros
mesh_terms: D000818:Animals; D005269:Femur / Q000378:metabolism; D015390:Gastric Bypass / Q000009:adverse effects* / Q000379:methods; D005753:Gastric Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D023421:Models, Animal; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013670:Sodium Pertechnetate Tc 99m / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m