title: Transient decrease in cerebral motor pathway fractional anisotropy after focal ischemic stroke in monkey.
abstract: In this study, diffusion tensor MRI was used to examine the restoration of the cerebral white matter of macaque monkeys after unilateral cerebral multiple microinfarctions. Post-stroke, the monkeys showed deficits in several neurological functions, including motor functions, but most of the deficits resolved within 6 weeks. Very interestingly, the fractional anisotropy (a value determined by diffusion tensor MRI), of the monkeys' affected motor pathways dropped transiently, indicating a damage in the neural tracts. However, it returned to normal levels within 6 weeks after the stroke, concomitant with the gradual recovery of motor functions at subacute phase.
authors.affiliation: Department of Integrated Biosciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan.
authors.forename: Yo
authors.initials: Y
authors.lastname: Chin
authors.forename: Yuki
authors.initials: Y
authors.lastname: Sato
authors.forename: Mitsuhito
authors.initials: M
authors.lastname: Mase
authors.forename: Tomomasa
authors.initials: T
authors.lastname: Kato
authors.forename: Bruno
authors.initials: B
authors.lastname: Herculano
authors.forename: Masaki
authors.initials: M
authors.lastname: Sekino
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ohsaki
authors.forename: Naohide
authors.initials: N
authors.lastname: Ageyama
authors.forename: Fumiko
authors.initials: F
authors.lastname: Ono
authors.forename: Keiji
authors.initials: K
authors.lastname: Terao
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Tatsuhiro
authors.initials: T
authors.lastname: Hisatsune
mesh_terms: D000818:Animals; D020520:Brain Infarction / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology*; D038524:Diffusion Magnetic Resonance Imaging; D004525:Efferent Pathways; D002546:Ischemic Attack, Transient / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D008252:Macaca fascicularis; D008297:Male; D020521:Stroke / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*