title: Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy.
abstract: Evidence for the involvement of inflammatory processes in the pathogenesis of Alzheimer's disease (AD) has been documented for a long time. However, the inflammation hypothesis in relation to AD pathology has emerged relatively recently. Even in this hypothesis, the inflammatory reaction is still considered to be a downstream effect of the accumulated proteins (amyloid beta (Abeta) and tau). This review aims to highlight the importance of the immune processes involved in AD pathogenesis based on the outcomes of the two major inflammation-relevant treatment strategies against AD developed and tested to date in animal studies and human clinical trials - the use of anti-inflammatory drugs and immunisation against Abeta.
authors.affiliation: Division of Clinical Neurosciences, School of Medicine, University of Southampton, Mailpoint 806, Level D, South Pathology Block, Southampton General Hospital, Southampton, SO16 6YD, UK. E.Zotova@soton.ac.uk.
authors.forename: Elina
authors.initials: E
authors.lastname: Zotova
authors.forename: James Ar
authors.initials: JA
authors.lastname: Nicoll
authors.forename: Raj
authors.initials: R
authors.lastname: Kalaria
authors.forename: Clive
authors.initials: C
authors.lastname: Holmes
authors.forename: Delphine
authors.initials: D
authors.lastname: Boche