title: Antibiotic treatment for bacterial meningitis caused by Listeria monocytogenes in a patient with multiple myeloma.
abstract: Multiple myeloma is a hematolymphoid malignancy, and patients with this disorder are frequently complicated by infection. An 80-year-old woman with multiple myeloma was complicated by bacterial meningitis, and was admitted to our hospital in August 2007. She initially received ceftriaxone, but culture of cerebrospinal fluid detected Listeria monocytogenes. Ampicillin was administered, but headache and pyrexia persisted for 2 weeks, and on cerebrospinal fluid examination, the proliferation of polymorphonuclear leukocytes had not resolved. After medication with meropenem was started, the clinical symptoms completely disappeared, and the abnormalities on cerebrospinal fluid examination resolved. The patient ultimately received meropenem for 27 days, resulting in a cure. In conclusion, meropenem is useful to treat bacterial meningitis caused by L. monocytogenes. This agent is indicated when ampicillin shows inadequate effect or if the patient has an allergy to ampicillin.
authors.affiliation: Department of Hematology, Tonami General Hospital, Tonami, Toyama, 939-1395, Japan. eievui7@p1.tst.ne.jp
authors.forename: Sadaya
authors.initials: S
authors.lastname: Matano
authors.forename: Shigehiko
authors.initials: S
authors.lastname: Satoh
authors.forename: Yukari
authors.initials: Y
authors.lastname: Harada
authors.forename: Hajime
authors.initials: H
authors.lastname: Nagata
authors.forename: Tatsuho
authors.initials: T
authors.lastname: Sugimoto
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008089:Listeria monocytogenes / Q000187:drug effects / Q000302:isolation & purification*; D008088:Listeriosis / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy*; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid / Q000150:complications / Q000188:drug therapy*; D009101:Multiple Myeloma / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents