Small intestinal submucosa plug for closure of dilated nephrostomy tracts: a pilot study in swine.
The aim of this study was to evaluate efficacy of a plug made of small intestinal submucosa (SIS) for closure of dilated nephrostomy tract in the kidney after nephroscopy. Ten kidneys in 5 swine had nephrostomy tracts dilated up to 8 mm. The SIS plug was placed into the dilated renal cortex under nephroscopic control. Follow-up arteriograms, retrograde pyelograms, and macroscopic and histologic studies at 24 h (n = 4), 6 weeks (n = 2), and 3 months (n = 4) were performed to evaluate the efficacy of the plug. The SIS plug effectively closed the dilated nephrostomy tract. Follow-up studies showed minimal changes of the kidneys, except for 1 small infarction, regarding inflammatory and foreign-body reactions and progressive scarring of the SIS. SIS plug is effective for occlusion of dilated nephrostomy tract after nephroscopy. Its efficacy should be compared with other therapeutic options.
Kakizawa
Hideyaki
H
Dotter Interventional Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, L-342, Portland, OR 97239-3098, USA.
Conlin
M J
MJ
Pavcnik
Dusan
D
Uchida
Barry T
BT
Loriaux
Marc
M
Kim
Young Hwan
YH
Keller
Frederick S
FS
Rösch
Josef
J
D000792:Angiography; D000818:Animals; D001672:Biocompatible Materials; D003094:Collagen; D004724:Endoscopy; D007413:Intestinal Mucosa / Q000637:transplantation*; D007669:Kidney Calculi / Q000601:surgery; D007672:Kidney Cortex / Q000601:surgery*; D009403:Nephrostomy, Percutaneous / Q000295:instrumentation*; D010865:Pilot Projects; D011183:Postoperative Complications / Q000517:prevention & control; D015641:Radiography, Interventional; D013552:Swine
D001672:Biocompatible Materials; D003094:Collagen