[Comparison of clinical features from patients with chronic hepatitis B between HBeAg negative and positive].
OBJECTIVE
To analyze different clinical features from patients with chronic hepatitis B between HBeAg negative and positive.


METHODS
354 patients with chronic hepatitis B (124 cases with HBeAg positive and 230 cases with HBeAg negative) were enrolled into this retrospective investigation. Comparisons were conducted according to their demographic, liver biochemical, virological characters and clinical diagnosis types.


RESULTS
(1) patients with chronic hepatitis B in HBeAg negative group have older age; moderate and severe chronic hepatitis occupied a lower proportion (P = 0.007 and 0.014). But fulminant hepatitis had a higher proportion (P = 0.008). (2) ALT, ALB, PTA and HBV DNA load of HBeAg negative group were lower than that of HBeAg positive group, but TBil in HBeAg negative group was higher; AST had no statistical significance between two groups. (3) In high HBV DNA load group ( > 10(5) copies/ml), HBeAg negative group had a lower proportion than HBeAg positive group (37.4% vs 55.6%, P = 0.001).


CONCLUSIONS
HBeAg-negative patients compared with HBeAg-positive patients had older age, lower serum HBV DNA level and other characteristics; HBeAg-negative patients maybe had serious disease.
Xu
Qi-Huan
QH
Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yet-sen University, Guangzhou 510630, China. xqh0303@yahoo.com.cn
Shu
Xin
X
Chen
Lu-Biao
LB
Zhang
Ka
K
Li
Gang
G
D000328:Adult; D000367:Age Factors; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006513:Hepatitis B e Antigens / Q000097:blood*; D019694:Hepatitis B, Chronic / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
D004279:DNA, Viral; D006513:Hepatitis B e Antigens