Effect of angiotensin II type 1 receptor antagonist valsartan on cardiac remodeling and left ventricular function in patients with acute ST-elevation myocardial infarction.
BACKGROUND
Left ventricular (LV) remodeling after acute ST-elevation myocardial infarction (STEMI) is an important predictor of mid and long-term prognosis. Pathological cardiac remodeling is associated with the development of LV systolic dysfunction and of congestive heart failure. The role of angiotensin converting enzyme (ACE) inhibitors in preventing cardiac remodeling and LV function improvement is well-known. The aim of our study was to assess the impact of an angiotensin II type 1 receptor antagonist administration instead of ACE inhibitor, in the standardized therapy of STEMI, on LV remodeling and function.


METHODS
We have studied 34 consecutive patients with STEMI (91% men, mean age 58.5 +/- 10.2 years, 41% with anterior location of MI, mean GISSI class 4.7 +/- 1.2) within 6 hours of symptom onset, who received standard fibrinolytic therapy with 1.5 million IU of streptokinase, followed by unfractionated heparin for at least 48 hours. These patients also received: aspirin (100%), valsartan (100%), statins (94%), beta-blockers (85%) and other drugs according to the physician's choice. Neither of them received ACE inhibitors. An echocardiography was performed at baseline and 6 months after STEMI. Left ventricular end-diastolic diameter (LVEDD) and left ventricular mass corrected to body surface (LVm_BS) were used to assess the remodeling process. Left ventricular ejection fraction (LVEF) and a wall motion index (WMI) based on the analysis of regional contractility of 17 segments were taken into account for the LV systolic function. Changes in these values from baseline to the end of the study were compared using the Wilcoxon statistical test for paired samples.


RESULTS
After six months follow-up, there were no significant statistical differences from baseline in LVEDD (from 52.1 +/-6.1 to 52.7 +/- 5.6 mm, Z = 0.61, p = 0.53) and in LVm_BS (from 104.8 +/- 27.5 to 105.2 +/- 27.8 g/m2, Z = -0.54, p = 0.54). There was a significant improvement of WMI (from 1.57 +/- 0.29 to 1.43 +/- 0.34, Z = -3.05. p = 0.002) and a significant increase of LVEF (from 41.0 +/- 7.1 to 45.2 +/- 10.0%, Z = 2.96, p = 0.003).


CONCLUSIONS
The results of this study suggested that administration of valsartan instead of ACE inhibitor, in consecutive patients with medium-risk STEMI, attenuates pathological LV remodeling and improves LV systolic function. However, as obtained within the first six months after the infarction, these results can not be generalized to the later period after STEMI.
Ovricenco
Eduard
E
Department of Cardiology, Bagdasar-Arseni Clinical Emergency Hospital, 10-12 Berceni str. Bucharest IV, Romania.
Sinescu
Crina
C
Dinescu
Smaranda
S
D000328:Adult; D000368:Aged; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use*; D056988:Anterior Wall Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006329:Heart Conduction System / Q000503:physiopathology; D006333:Heart Failure / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D013777:Tetrazoles / Q000627:therapeutic use*; D016896:Treatment Outcome; D014633:Valine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000068756:Valsartan; D016277:Ventricular Function, Left / Q000187:drug effects*; D020257:Ventricular Remodeling / Q000187:drug effects*
D047228:Angiotensin II Type 1 Receptor Blockers; D005343:Fibrinolytic Agents; D013777:Tetrazoles; D000068756:Valsartan; D014633:Valine