title: Volume loss of the medial temporal lobe structures in subjective memory impairment.
abstract: OBJECTIVE
  Subjective memory impairment (SMI) has been suggested as a manifestation of Alzheimer's Disease (AD) preceding mild cognitive impairment (MCI). In this study, we determined the volumes of the hippocampus, the entorhinal cortex (EC) and the amygdala to provide biological evidence for AD in SMI.
  
  
  METHODS
  Regional volumetric measures were manually traced on 3-Tesla MRI scans.
  
  
  RESULTS
  Total brain volume did not differ between the groups. Individuals with SMI had reduced volumes of the hippocampus bilaterally (right p = 0.001; left p < 0.001), the bilateral EC (right p = 0.031, left p = 0.006) and the right amygdala (p = 0.01) compared to the control group.
  
  
  CONCLUSIONS
  Volume reduction of bilateral hippocampus, bilateral EC and right amygdala supports the concept of SMI as a very early manifestation of AD prior to MCI. SMI may indicate awareness of a degenerative process that can still be functionally compensated.
authors.affiliation: Department of Psychiatry, University of Bonn, Germany. nadine.striepens@web.de
authors.forename: Nadine
authors.initials: N
authors.lastname: Striepens
authors.forename: Lukas
authors.initials: L
authors.lastname: Scheef
authors.forename: Andrea
authors.initials: A
authors.lastname: Wind
authors.forename: Julius
authors.initials: J
authors.lastname: Popp
authors.forename: Annika
authors.initials: A
authors.lastname: Spottke
authors.forename: Déirdre
authors.initials: D
authors.lastname: Cooper-Mahkorn
authors.forename: Husam
authors.initials: H
authors.lastname: Suliman
authors.forename: Michael
authors.initials: M
authors.lastname: Wagner
authors.forename: Hans H
authors.initials: HH
authors.lastname: Schild
authors.forename: Frank
authors.initials: F
authors.lastname: Jessen
mesh_terms: D000368:Aged; D000679:Amygdala / Q000473:pathology; D001057:Apolipoproteins E / Q000235:genetics; D001921:Brain / Q000473:pathology; D004493:Education; D018728:Entorhinal Cortex / Q000473:pathology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000473:pathology* / Q000523:psychology; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D013702:Temporal Lobe / Q000473:pathology*
chemical_list: D001057:Apolipoproteins E