title: Pathway analysis of microRNAs in mouse heart development.
abstract: MicroRNAs (miRNAs) are non-coding RNAs, which regulate gene expression by promoting degradation or repressing translation of targeted transcripts. Current researches indicate that microRNAs play essential roles in heart development, but their regulating mechanisms are still elusive. Using computational methods, we analysed microRNAs associated pathways in mouse heart development and found that 24 pathways were enriched with target genes of microRNAs. Some of these pathways are reported important in heart development, while others are associated with cancer. The computational results could be used to guide experimental design for the further understanding of the microRNAs function in heart development.
authors.affiliation: School of Life Science and Technology, Tongji University, Shanghai 200092, China. 6guns@tongji.edu.cn
authors.forename: Ganqiang
authors.initials: G
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Ding
authors.forename: Haiyun
authors.initials: H
authors.lastname: Wang
authors.forename: Jinyan
authors.initials: J
authors.lastname: Huang
authors.forename: Qing
authors.initials: Q
authors.lastname: Jing
authors.forename: Bairong
authors.initials: B
authors.lastname: Shen
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods*; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000254:growth & development; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D035683:MicroRNAs