Acute motor and sensory axonal neuropathy and concomitant encephalopathy during tumor necrosis factor-alpha antagonist therapy.
A woman with Crohn's disease developed acute neuropathy and concomitant encephalopathy while being treated with infliximab. The etiological investigations were negative. Infliximab was stopped and she was given four series of polyvalent immunoglobulin injections. Eighteen months later, the encephalitic symptoms had disappeared and the neuropathic symptoms were less severe. TNF-alpha antagonists have been previously blamed for triggering neurological disorders, but no cases of acute neuropathy concomitant with encephalopathy have been reported so far.
Faivre
Anthony
A
Hôpital d'Instruction des Armées Sainte-Anne, Service de Neurologie, Boulevard Ste-Anne, BP 20545 83041 Toulon cedex 9, France; Service de Neurologie et Maladies Neuromusculaires, Centre de Référence national pour les Maladies Neuromusculaires et la SLA, Hôpital la Timone, 264 boulevard St-Pierre, 13385 Marseille cedex 05, France.
Franques
Jérome
J
De Paula
Andre Maues
AM
Gutierrez
Mariana
M
Bret
Sandie
S
Aubert
Sandrine
S
Attarian
Shahram
S
Pouget
Jean
J
D000208:Acute Disease; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology; D003424:Crohn Disease / Q000188:drug therapy; D005260:Female; D006801:Humans; D000069285:Infliximab; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000139:chemically induced* / Q000473:pathology; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab