Lonomia obliqua venom: In vivo effects and molecular aspects associated with the hemorrhagic syndrome.
Caterpillar envenomation has been an emergent health issue. Lonomia obliqua is a medically important animal that causes a hemorrhagic syndrome that can progress to acute renal failure, intracranial hemorrhage and death. In the past few years the molecular characterization of L. obliqua venom in addition to experimental models has provided fundamental information to the understanding of the envenomation syndrome. Herein studies from several authors which characterized the complex toxic-pharmacological actions of whole venom are reviewed.
Pinto
Antônio F M
AF
Laboratório de Bioquímica Farmacológica, Centro de Biotecnologia (UFRGS), Av. Bento Gonçalves, 9500, CEP 91501-970, Porto Alegre, RS, Brazil.
Berger
Markus
M
Reck
José
J
Terra
Renata M S
RM
Guimarães
Jorge A
JA
D000818:Animals; D000997:Antivenins / Q000627:therapeutic use; D001180:Arthropod Venoms / Q000737:chemistry / Q000633:toxicity*; D001777:Blood Coagulation / Q000187:drug effects; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006474:Hemorrhagic Disorders / Q000097:blood / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007299:Insect Bites and Stings / Q000188:drug therapy / Q000473:pathology; D007668:Kidney / Q000187:drug effects; D007814:Larva / Q000737:chemistry / Q000235:genetics; D008954:Models, Biological; D009036:Moths / Q000737:chemistry* / Q000235:genetics / Q000254:growth & development; D010974:Platelet Aggregation / Q000187:drug effects; D013577:Syndrome
D000997:Antivenins; D001180:Arthropod Venoms