Treatment of primary angiitis of the central nervous system in childhood with mycophenolate mofetil.
OBJECTIVE
To assess the use of mycophenolate mofetil (MMF) in the treatment of refractory primary angiitis of the CNS in childhood (cPACNS).


METHODS
A retrospective chart review was performed in patients with cPACNS who were treated with MMF following failure of a combination of corticosteroids and another immunosuppressant.


RESULTS
Three patients from two centres were included in this study. The age of onset of disease was 5, 6 and 9 years. All the patients improved when treated with MMF, such that the dose of corticosteroids could be weaned or stopped.


CONCLUSIONS
MMF should be considered for maintenance treatment in the management of patients with cPACNS refractory to the combination of corticosteroids and first-line immunosuppressive agents.
Sen
Ethan S
ES
Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, UK.
Leone
Valentina
V
Abinun
Mario
M
Forsyth
Robert
R
Ramesh
Venkateswaran
V
Friswell
Mark
M
O'Callaghan
Finbar
F
Ramanan
Athimalaipet V
AV
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome; D020293:Vasculitis, Central Nervous System / Q000188:drug therapy* / Q000473:pathology
D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid