In vivo modulation of HMGA2 expression.
While the biochemical role of the HMGA proteins has largely been elucidated in tissue culture, the majority of the insight as to their physiological functions in the processes of proliferation and development has been established in animal models of overexpression (transgenic) and null mice (knockouts). An emphasis has been placed on the HMGA2 studies which have defined its critical role in mesenchymal proliferation and differentiation.
Ashar
Hena R
HR
HMGene, Inc. 675 US Highway One, North Brunswick, NJ 08902, USA.
Chouinard
Roland A
RA
Dokur
Madhavi
M
Chada
Kiran
K
D050156:Adipogenesis; D000818:Animals; D025743:HMGA2 Protein / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D008067:Lipoma / Q000378:metabolism; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D013091:Spermatogenesis; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D013737:Testis / Q000166:cytology / Q000378:metabolism
D025743:HMGA2 Protein