title: Augmented peripheral chemoreflex in patients with heart failure and inspiratory muscle weakness.
abstract: We hypothesized that heart failure patients with inspiratory muscle weakness (IMW) present greater peripheral chemoreflex responsiveness and augmented exercise ventilatory oscillation compared to patients with preserved inspiratory muscle strength. We studied 19 heart failure patients: 9 with IMW (maximal inspiratory pressure [PImax]<70% of predicted) and 10 with preserved inspiratory muscle strength. Inspiratory muscle strength was measured via pressure transducer. Peripheral chemoreflex was evaluated by the single-breath CO(2) test. Exercise ventilatory oscillation was determined as the ratio between amplitude and mean of each oscillation during incremental exercise. Patients with IMW had greater peripheral chemoreflex response (0.11+/-0.03 l min(-1) Torr(-1)) than those with preserved inspiratory muscle strength (0.07+/-0.03 l min(-1) Torr(-1), p=0.02). Moreover, there was a significant and inverse correlation between PImax and peripheral chemoreflex response (r=-0.57, p=0.01). Likewise, there was a significant and inverse correlation between PImax and ventilatory oscillations (r=-0.46, p=0.04). Our findings indicate that IMW is linked to increased peripheral chemoreflex and augmented exercise ventilatory oscillation in patients with chronic heart failure.
authors.affiliation: Exercise Pathophysiology Research Laboratory, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Carine C
authors.initials: CC
authors.lastname: Callegaro
authors.forename: Denis
authors.initials: D
authors.lastname: Martinez
authors.forename: Paula A B
authors.initials: PA
authors.lastname: Ribeiro
authors.forename: Marta
authors.initials: M
authors.lastname: Brod
authors.forename: Jorge P
authors.initials: JP
authors.lastname: Ribeiro
mesh_terms: D000328:Adult; D002245:Carbon Dioxide; D002628:Chemoreceptor Cells / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation / Q000379:methods; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology; D018908:Muscle Weakness / Q000473:pathology*; D018482:Muscle, Skeletal / Q000503:physiopathology*; D011237:Predictive Value of Tests; D012123:Pulmonary Ventilation / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000473:pathology*
chemical_list: D002245:Carbon Dioxide