Brain activation during autobiographical relationship episode narratives: a core conflictual relationship theme approach.
The authors combined the core conflictual relationship theme (CCRT) method and functional magnetic resonance imaging (fMRI) to identify brain regions involved in recall of autobiographical relationship episodes, a key process in psychotherapy. Relationship narratives were obtained from healthy subjects and scored for CCRT relationship themes and emotion. Autobiographical personal and nonautobiographical control narratives were presented in a block-design fMRI experiment. Personal versus control narratives showed activations in anterior cingulate, precuneus, inferior and middle frontal gyri, and inferior parietal lobule. These are regions involved in autobiographical memory, theory of mind, self-referential processing, and emotion. In an exploratory analysis, higher CCRT scores correlated with increased brain activation in the left hippocampus, parahippocampal gyrus, and middle occipital gyrus. This suggests that brain systems subserving memory processes are more active when recalling relationship episodes with greater CCRT content.
Loughead
James W
JW
Department of Psychiatry, University of Pennsylvania, Gates Building, 10th floor, 3400 Spruce Street, Philadelphia, PA 19104, USA. loughead@upenn.edu
Luborsky
Lester
L
Weingarten
Carol P
CP
Krause
Elizabeth D
ED
German
Ramaris E
RE
Kirk
Daniel
D
Gur
Ruben C
RC
D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D003220:Conflict, Psychological; D004292:Dominance, Cerebral / Q000502:physiology; D004644:Emotions / Q000502:physiology; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D007398:Interpersonal Relations; D008279:Magnetic Resonance Imaging; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D033262:Narration; D010100:Oxygen / Q000097:blood*; D011369:Professional-Patient Relations; D011575:Psychoanalytic Therapy; D012650:Self Disclosure; D014167:Transference, Psychology
D010100:Oxygen