Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes.
FRET analysis has been used to examine the folded conformations and differing kinetic stabilities of two DNA G-quadruplexes (c-kit 1 and c-kit 2) derived from sequences found in the promoter of the c-kit proto-oncogene.
Fegan
Adrian
A
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW.
Shirude
Pravin S
PS
Ying
Liming
L
Balasubramanian
Shankar
S
D031541:Fluorescence Resonance Energy Transfer; D054856:G-Quadruplexes; D007700:Kinetics; D009691:Nucleic Acid Denaturation; D011401:Promoter Regions, Genetic; D019009:Proto-Oncogene Proteins c-kit / Q000737:chemistry* / Q000235:genetics; D013816:Thermodynamics
D019009:Proto-Oncogene Proteins c-kit