Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels.
Ca(2+) channels that underlie mitochondrial Ca(2+) transport first reported decades ago have now just recently been precisely characterized electrophysiologically. Numerous data indicate that mitochondrial Ca(2+) uptake via these channels regulates multiple intracellular processes by shaping cytosolic and mitochondrial Ca(2+) transients, as well as altering the cellular metabolic and redox state. On the other hand, mitochondrial Ca(2+) overload also initiates a cascade of events that leads to cell death. Thus, characterization of mitochondrial Ca(2+) channels is central to a comprehensive understanding of cell signaling. Here, we discuss recent progresses in the biophysical and electrophysiological characterization of several distinct mitochondrial Ca(2+) channels.
Ryu
Shin-Young
SY
Department of Pharmacology and Physiology, and Mitochondrial Research Innovation Group, University of Rochester Medical Center, Rochester, NY 14642, USA.
Beutner
Gisela
G
Dirksen
Robert T
RT
Kinnally
Kathleen W
KW
Sheu
Shey-Shing
SS
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D010539:Permeability; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism*; D015398:Signal Transduction
D015220:Calcium Channels; D019837:Ryanodine Receptor Calcium Release Channel; C034703:mitochondrial calcium uniporter; D002118:Calcium