title: Antihyperglycemic and antihyperlipidemic activities of methanol:water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats.
abstract: The present study was taken up to identify potent antihyperglycemic fraction from the aqueous extract of Syzygium alternifolium (SA) seeds, using bioassay guided fractionation. The isolated fraction C at a dose of 50 mg/kg.b.w produced the maximum fall of 83% in the blood glucose level in the diabetic rats after 6 h of the treatment. The administration of fraction C (50 mg/kg.b.w) once daily for 30 days in STZ diabetic rats resulted in a significant decrease in blood glucose, glycosylated haemoglobin with a significant rise in plasma insulin level. Further fraction C showed antihyperlipidemic activity as evidenced by significant decrease in serum TC, TG, LDL-C, VLDL-C levels coupled together with elevation of HDL-C level in diabetic rats. A significant decrease in the activities of SGOT, SGPT, ALP and decreased levels of serum urea and creatinine in diabetic treated rats when compared to diabetic untreated rats, indicate the protective role against liver and kidney damage and non-toxic property of the fraction C. A comparison was made between the action of fraction C and antidiabetic drug glibenclamide (20 mg/kg.b.w). The effect of fraction C was more prominent when compared to that of glibenclamide.
authors.affiliation: Department of Biochemistry, Sri Venkateswara University, Tirupati 517502, AP, India.
authors.forename: Ramesh Babu
authors.initials: RB
authors.lastname: Kasetti
authors.forename: Maddirala Dilip
authors.initials: MD
authors.lastname: Rajasekhar
authors.forename: Vinay Kumar
authors.initials: VK
authors.lastname: Kondeti
authors.forename: Shaik Sameena
authors.initials: SS
authors.lastname: Fatima
authors.forename: Ethamakula Guravaiah Tiruvenkata
authors.initials: EG
authors.lastname: Kumar
authors.forename: Sirasanagandla
authors.initials: S
authors.lastname: Swapna
authors.forename: Bellamkonda
authors.initials: B
authors.lastname: Ramesh
authors.forename: Chippada Appa
authors.initials: CA
authors.lastname: Rao
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects; D005591:Chemical Fractionation; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D005905:Glyburide / Q000494:pharmacology; D006442:Glycated Hemoglobin / Q000032:analysis / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008111:Liver Function Tests; D008297:Male; D000432:Methanol / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry; D013311:Streptozocin; D027842:Syzygium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001219:Aspartate Aminotransferases; D001786:Blood Glucose; D005905:Glyburide; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007328:Insulin; D008055:Lipids; D000432:Methanol; D010936:Plant Extracts; D013311:Streptozocin; D014867:Water