[The effect of the expression and influence of MMP-9 on prognosis of nasal polyps].
OBJECTIVE
To study the expression of MMP-9 and eosinophils in nasal polyps and its influence on the prognosis.


METHODS
Study the expression of MMP-9 and EOS on the tissue of nasal polyps of patients who were cured or recurrent and normal nasal mucosa (NM) by immunohistochemistry and HE staining.


RESULTS
In the patients of recurrent group (Group B), the expression of MMP-9 was much stronger than that of good prognosis group (Group A) and NM. The MMP-9 was stronger in the eosinophil nasal polyps than that of non-eosinophil groups. The percentage of EOS in Group A was 16.67%, while 62.50% in the Group B.


CONCLUSIONS
The stronger expression of MMP-9 on Group B and eosinophil group indicated that MMP-9 might affect the prognosis of nasal polyps through inducing the number of EOS in the mucosa. MMP-9 may be one of the risk factors for the relapse of nasal polyps.
Chen
Jiangbo
J
Department of Otolaryngology, the Third Xiangya Hospital, Central South University, Chan-gsha, 410013, China.
Wang
Tiansheng
T
Sun
Hong
H
D000328:Adult; D016022:Case-Control Studies; D004804:Eosinophils / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D009297:Nasal Mucosa / Q000378:metabolism; D009298:Nasal Polyps / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D012008:Recurrence
D020780:Matrix Metalloproteinase 9