[The effect of the composition of hydrophilic base on pharmaceutical availability of prednisolone].
Studies on the effect of hydrophilic gel composition on pharmaceutical availability of prednisolone revealed that the half-release times were differentiated depening on the substances added 4% of methylcellulose hydrogel, propylene glycol-1,2 and N,N-dimethylacetamide. Hydrogels containing 15% of N,N-dimethylacetamide and 20% propylene glycol-1,2 as well 0.25% or 0.5% of active substance characterized by the largest pharmaceutical availability, for this gels was found shortened time of prednisolone the half-release.
Szcześniak
Maria
M
Katedra i Zakład Technologii Postaci Leku, Akademia Medyczna we Wrocławiu. marias@ktpl.am.wroc.pl
Pluta
Janusz
J
D000081:Acetamides / Q000737:chemistry; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D004339:Drug Compounding; D005079:Excipients; D006207:Half-Life; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry; D008747:Methylcellulose / Q000737:chemistry; D011239:Prednisolone / Q000737:chemistry* / Q000493:pharmacokinetics*; D011409:Propylene Glycols / Q000737:chemistry; D014867:Water / Q000737:chemistry
D000081:Acetamides; D004337:Drug Carriers; D005079:Excipients; D020100:Hydrogels; D011409:Propylene Glycols; D014867:Water; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008747:Methylcellulose; D011239:Prednisolone; C013959:dimethylacetamide