title: SPAKling insight into blood pressure regulation.
abstract: Arterial hypertension is one of the most important health problems in industrialized cities. Blood pressure levels are influenced by renal salt handling and salt reabsorption in the kidney. In this Closeup, Castañeda-Bueno and Gamba discuss the work from Alessi and coworkers on the in vivo roles of the SPAK kinase in defining blood pressure levels.
authors.affiliation: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México.
authors.forename: María
authors.initials: M
authors.lastname: Castañeda-Bueno
authors.forename: Gerardo
authors.initials: G
authors.lastname: Gamba
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D006706:Homeostasis; D007668:Kidney / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D012492:Salts / Q000378:metabolism
chemical_list: D012492:Salts; C486407:Stk39 protein, mouse; D017346:Protein Serine-Threonine Kinases