title: Noninvasive monitoring of placental oxygenation by near-infrared spectroscopy.
abstract: We evaluated the clinical usefulness of near-infrared spectroscopic quantitative measurement of placental oxygenation for the noninvasive estimation of uteroplacental function in pregnant women. We performed a prospective, observational clinical study. Women without complications (N = 15), women with threatened preterm delivery (TPD; N = 6), and women with intrauterine fetal growth restriction (IUGR; N = 6) were enrolled. Measurements of placental tissue oxygenation index (TOI) using the NIRO-300 (Hamamatsu Photonics, Hamamatsu City, Japan) were recorded. Mean TOI was 72.3 +/- 5.3% in women without complications, 72.9 +/- 5.6% in pregnant women with TPD, and 78.7 +/- 3.0% in pregnant women with IUGR. Mean TOI in pregnant women with IUGR was significantly higher than that of the other two groups (P < 0.05). In the IUGR group, although gestational age at measurement on admission was less than that made during hospitalization (P < 0.05), there were no differences in the TOI in relation to gestational age at measurement. Higher TOIs in pregnant women suggest decreased placental function. Monitoring the TOI by near-infrared spectroscopic quantitative measurement may have a high potential for clinical application, particularly in prenatal management.
authors.affiliation: Department of Obstetrics and Gynecology, International Medical Center of Japan, Shinjuku, Japan. jkakogaw@imcj.hosp.go.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Kakogawa
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sumimoto
authors.forename: Takakazu
authors.initials: T
authors.lastname: Kawamura
authors.forename: Shigeki
authors.initials: S
authors.lastname: Minoura
authors.forename: Naohiro
authors.initials: N
authors.lastname: Kanayama
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D010100:Oxygen / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011446:Prospective Studies; D019265:Spectroscopy, Near-Infrared
chemical_list: D010100:Oxygen