title: Extrusion-spheronisation of microcrystalline cellulose pastes using a non-aqueous liquid binder.
abstract: An experimental investigation of extrusion-spheronisation (E-S) of a novel microcrystalline cellulose (MCC) formulation, comprising dimethyl sulfoxide (DMSO) as the granulating liquid, is reported. The extrusion-spheronisation performance of DMSO/MCC pastes is compared to that of similar water/MCC formulations and their rheological behaviours similarly assessed using lubricated squeeze flow. A case study involving water, DMSO and anhydrous ethanol yields important information regarding the physico-chemical properties necessary for solvents to be suitable for the extrusion of MCC.
authors.affiliation: Department of Chemical Engineering and Biotechnology, New Museums Site, Pembroke Street, Cambridge, CB2 3RA, UK.
authors.forename: S
authors.initials: S
authors.lastname: Mascia
authors.forename: C
authors.initials: C
authors.lastname: Seiler
authors.forename: S
authors.initials: S
authors.lastname: Fitzpatrick
authors.forename: D I
authors.initials: DI
authors.lastname: Wilson
mesh_terms: D002482:Cellulose / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D000431:Ethanol / Q000737:chemistry; D005079:Excipients / Q000737:chemistry*; D012212:Rheology; D012997:Solvents / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods; D014867:Water / Q000737:chemistry
chemical_list: D005079:Excipients; D012997:Solvents; D014867:Water; D000431:Ethanol; D002482:Cellulose; C109691:microcrystalline cellulose; D004121:Dimethyl Sulfoxide