title: Phase II trial of a trimodality regimen for stage III non-small-cell lung cancer using chemotherapy as induction treatment with concurrent hyperfractionated chemoradiation with carboplatin and paclitaxel followed by subsequent resection: a single-center study.
abstract: PURPOSE We started a phase II trial of induction chemotherapy and concurrent hyperfractionated chemoradiotherapy followed by either surgery or boost chemoradiotherapy in patients with advanced, stage III disease. The purpose is to achieve better survival in the surgery group with minimum morbidity and mortality. PATIENTS AND METHODS Patients treated from 1998 to 2002 with neoadjuvant chemoradiotherapy and surgical resection for stage III NSCLC were analyzed. The treatment consisted of four cycles of induction chemotherapy with carboplatin/paclitaxel followed by chemoradiotherapy with a reduced dose of carboplatin/paclitaxel and accelerated hyperfractionated radiotherapy with 1.5 Gy twice daily up to 45 Gy. After restaging, operable patients underwent thoracotomy. Inoperable patients received chemoradiotherapy up to 63 Gy. Study end points included resectability, pathologic response, and survival. Results One hundred twenty patients were enrolled; 25% patients had stage IIIA, 73% had stage IIIB, and 2% stage IV. After treatment, 47.5% had downstaging, 29.2% had stable disease, and 23.3% had progressive disease. Thirty patients (25%) were not eligible for operation because of progressive disease, stable disease, and/or functional deterioration with one treatment-related death. The 30-day mortality was 5% in patients who underwent operation. The 5-year survival rate for 120 patients was 21.7%, and it was 43.1% in patients with complete resection. In postoperative patients with stage N0 disease, 5-year survival was 53.3%; if stage N2 or N3 disease was still present, 5-year survival was 33.3%. CONCLUSION Staging and treatment with chemoradiotherapy and complete resection performed in experienced centers achieve acceptable morbidity and mortality.
authors.affiliation: FETCS, Department of Thoracic Surgery, Robert-Bosch-Hospital Klinik Schillerhoehe, Thoracic Center, D-70839 Stuttgart-Gerlingen, Germany. godehard.friedel@klinik-schillerhoehe.de
authors.forename: Godehard
authors.initials: G
authors.lastname: Friedel
authors.forename: Wilfried
authors.initials: W
authors.lastname: Budach
authors.forename: Juergen
authors.initials: J
authors.lastname: Dippon
authors.forename: Werner
authors.initials: W
authors.lastname: Spengler
authors.forename: Susanne Martina
authors.initials: SM
authors.lastname: Eschmann
authors.forename: Christina
authors.initials: C
authors.lastname: Pfannenberg
authors.forename: Fawaz
authors.initials: F
authors.lastname: Al-Kamash
authors.forename: Thorsten
authors.initials: T
authors.lastname: Walles
authors.forename: Hermann
authors.initials: H
authors.lastname: Aebert
authors.forename: Thomas
authors.initials: T
authors.lastname: Kyriss
authors.forename: Stefanie
authors.initials: S
authors.lastname: Veit
authors.forename: Martin
authors.initials: M
authors.lastname: Kimmich
authors.forename: Michael
authors.initials: M
authors.lastname: Bamberg
authors.forename: Martin
authors.initials: M
authors.lastname: Kohlhaeufl
authors.forename: Volker
authors.initials: V
authors.lastname: Steger
authors.forename: Thomas
authors.initials: T
authors.lastname: Hehr
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000008:administration & dosage; D011379:Prognosis; D012074:Remission Induction; D015996:Survival Rate; D013908:Thoracotomy; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D016190:Carboplatin; D017239:Paclitaxel