title: Successful treatment of life-threatening Candida peritonitis in a child with abdominal non-Hodgkin lymphoma using Efungumab and amphotericin B colloid dispersion.
abstract: Invasive fungal infections are serious complications of cancer therapy. We present a case report of a 12-year-old boy diagnosed with abdominal non-Hodgkin lymphoma and fecal and Candida peritonitis during induction chemotherapy. The invasive mycosis was managed using a combined approach of systemic antifungal agents including efungumab and surgical interventions. Efungumab, a recombinant antibody that inhibits extracellular heat shock protein 90, was used in combination with amphotericin B colloid dispersion after the failure of standard approaches.
authors.affiliation: Departments of Pediatric Oncology, University Hospital Brno, Czech Republic. zkrenova@fnbrno.cz
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Krenova
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Pavelka
authors.forename: Petr
authors.initials: P
authors.lastname: Lokaj
authors.forename: Jarmila
authors.initials: J
authors.lastname: Skotakova
authors.forename: Ivana
authors.initials: I
authors.lastname: Kocmanova
authors.forename: Otakar
authors.initials: O
authors.lastname: Teyschl
authors.forename: Leos
authors.initials: L
authors.lastname: Kren
authors.forename: Peter
authors.initials: P
authors.lastname: Mudry
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Sterba
mesh_terms: D000008:Abdominal Neoplasms / Q000150:complications* / Q000188:drug therapy; D000666:Amphotericin B / Q000008:administration & dosage*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D061067:Antibodies, Monoclonal, Humanized; D000935:Antifungal Agents / Q000008:administration & dosage*; D002177:Candidiasis / Q000188:drug therapy*; D002648:Child; D004359:Drug Therapy, Combination; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000188:drug therapy; D008297:Male; D010538:Peritonitis / Q000188:drug therapy*
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000935:Antifungal Agents; D018841:HSP90 Heat-Shock Proteins; D000666:Amphotericin B; C512268:efungumab