[Bone and Men's Health. Function of androgen receptor in bone tissues].
Androgen is well established to exert anabolic action for skeletal tissues beyond sex difference. However, the target cells/genes remain to be identified. Recently, we have generated a mouse line selectively ablated androgen receptor gene in osteoclasts, and found osteoporotic phenotype in male mutants, indicating that anabolic androgen action is attributed to its repressive action for bone resorption.
Kato
Shigeaki
S
IMCB, The University of Tokyo/ERATO, JST.
Imai
Yuuki
Y
D000818:Animals; D001862:Bone Resorption / Q000209:etiology / Q000517:prevention & control; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008660:Metabolism; D051379:Mice; D011944:Receptors, Androgen / Q000235:genetics / Q000502:physiology*
D011944:Receptors, Androgen