HLA typing in uveitis: use and misuse.
OBJECTIVE
To evaluate the role of HLA typing as a diagnostic test in patients with uveitis.


METHODS
Perspective derived from a literature review and analysis of reported results.


METHODS
Published data on the HLA associations of several uveitis entities and their prevalence among patients and the general population were used to calculate the positive predictive value of HLA testing as a diagnostic test for these disorders.


RESULTS
For nearly all diagnostic entities evaluated (including multiple sclerosis-associated intermediate uveitis, birdshot chorioretinitis, sympathetic ophthalmic, Behçet disease, and Vogt-Koyanagi-Harada disease), the positive predictive value was low (< 0.50), indicating the limited usefulness of routinely applied HLA typing as a diagnostic test. HLA-B27 testing may be of value in identifying a previously undiagnosed or misdiagnosed spondyloarthropathy among patients with recurrent acute anterior uveitis.


CONCLUSIONS
In general, HLA typing has limited usefulness as a diagnostic test in patients with uveitis.
Zamecki
Katherine J
KJ
Department of Ophthalmology, The Mount Sinai School of Medicine, New York, NY 10029, USA.
Jabs
Douglas A
DA
D003941:Diagnostic Techniques, Ophthalmological; D006680:HLA Antigens; D006650:Histocompatibility Testing; D006801:Humans; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014605:Uveitis / Q000175:diagnosis*
D006680:HLA Antigens