[CA 125 expression in cervical and vaginal secretions in women in normal reproductive period].
OBJECTIVE
To investigate the tumor-associated antigen CA125 expression in the serum and cervical and vaginal secretions in women during normal reproductive period, and explore the clinical value of detecting tumor markers in the cervical and vaginal secretions.


METHODS
A total of 145 women in reproductive period were divided into 3 age groups (20-29 years, 30-39 years, and over 40 years), and their CA125 levels in cervical secretion, vaginal secretion and serum were detected by automatic electro-chemiluminescent immunoassay.


RESULTS
CA125 levels in the cervical secretion, vaginal secretion and serum showed no significant difference between the 3 age groups (P>0.05). In each group, CA125 levels differed significantly between the cervical secretion, vaginal secretion and serum (P<0.001). In the 145 women, the average CA125 level was 497.82 - or + 75.29 U/ml in the cervical secretion, 114.66 - or + 26.40 U/ml in vaginal secretion and 18.06 - or + 3.35 U/ml in serum, showing significant differences between them (P<0.001).


CONCLUSIONS
CA125 expression level is significantly higher in the cervical and vaginal secretions than in the serum in women in normal reproductive period, and its levels in cervical and vaginal secretions can be more sensitive and convenient for early detection of related diseases.
He
Shu-ming
SM
Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. heshuming@zsxlyy.com
Xing
Fu-qi
FQ
Sui
Hong
H
Wang
Yong-li
YL
Mai
Xiao-fan
XF
Luo
Zheng-qin
ZQ
Chen
Xiu-qing
XQ
Chen
Guang-hui
GH
Kong
Zi-jing
ZJ
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D018394:CA-125 Antigen / Q000097:blood / Q000378:metabolism*; D002582:Cervix Mucus / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D014621:Vagina / Q000378:metabolism*; D055815:Young Adult
D015415:Biomarkers; D018394:CA-125 Antigen