Synthesis and characterization of a redox- and light-sensitive MRI contrast agent.
A redox- and light-sensitive, T(1)-weighted magnetic resonance imaging (MRI) contrast agent which tethers a spiropyran(SP)/merocyanine(MC) motif to a Gd-DO3A moiety was synthesized and characterized. When in the dark, the probe is in its MC form which has an r(1) relaxivity of 2.51 mM(-1)s(-1) (60MHz, 37°C). After irradiation with visible light or mixing with NADH, the probe experiences an isomerization and the r(1) relaxivity decreased 18% and 26%, respectively. Additionally, the signal intensity in MRI showed an observable decrease after the compound was mixed with NADH.
Tu
Chuqiao
C
Department of Biomedical Engineering, University of California, Davis, CA 95616, USA.
Osborne
Elizabeth A
EA
Louie
Angelique Y
AY