title: The role of race and trust in tissue/blood donation for genetic research.
abstract: BACKGROUND
  Public willingness to donate tissue samples is critical to genetic research. Prior work has linked minority status and mistrust with less willingness to provide specimens. Some have suggested recruitment of prior research participants to address these barriers. We present data from a genetic epidemiology study with a request for blood and/or saliva specimens to (1) measure willingness to donate tissue/blood samples, (2) identify demographic, trust, and other factors associated with willingness to donate samples, and (3) measure willingness to participate in future genetic research.
  
  
  METHODS
  We surveyed participants in the North Carolina Colorectal Cancer Study, which included biologic sample collection from consenting participants. Participants were later asked about sample provision; trust in researchers, and future research participation.
  
  
  RESULTS
  African Americans were less likely to give a blood sample, when compared with whites (21% vs. 13%, P < 0.05). After controlling for "trust," this difference was no longer statistically significant (17% vs. 13%, P = 0.27). Those who had given samples were more likely to express willingness to participate in future research.
  
  
  CONCLUSIONS
  Despite prior participation in a genetic epidemiology study, factors associated with provision of tissue samples reflected many previously identified demographic factors (race and trust). Interventions to improve and demonstrate the trustworthiness of the research team and recruitment of subjects with a record of sample donation might enhance future study participation.
authors.affiliation: School of Medicine, Emory University, Atlanta, Georgia 30331, USA. jcbusse@emory.edu
authors.forename: Jada
authors.initials: J
authors.lastname: Bussey-Jones
authors.forename: Joanne
authors.initials: J
authors.lastname: Garrett
authors.forename: Gail
authors.initials: G
authors.lastname: Henderson
authors.forename: Mairead
authors.initials: M
authors.lastname: Moloney
authors.forename: Connie
authors.initials: C
authors.lastname: Blumenthal
authors.forename: Giselle
authors.initials: G
authors.lastname: Corbie-Smith
mesh_terms: D044383:Black People / Q000523:psychology*; D001782:Blood Donors; D005260:Female; D036281:Genetic Research; D006801:Humans; D008297:Male; D008875:Middle Aged; D009927:Tissue and Organ Procurement; D035502:Trust; D044465:White People / Q000523:psychology*; D001741:Black or African American