title: Simple and effective method for producing [11C]phosgene using an environmental CCl4 gas detection tube.
abstract: BACKGROUND
  Carbon-11-labeled phosgene is an important labeling precursor for PET molecular probes. Despite the usefulness of [(11)C]phosgene, some difficulties, especially in the formation of [(11)C]phosgene process from [(11)C]CCl(4), hamper its use. The present article shows a simple preparation method for [(11)C]phosgene.
  
  
  METHODS
  [(11)C]CCl(4) was obtained using the conventional method by passing a mixture of [(11)C]CH(4) and Cl(2) through a heated quartz tube. The [(11)C]CCl(4) was transformed to [(11)C]phosgene simply by passing through a pretreatment tube of a Kitagawa gas detection system for the working-environmental CCl(4) concentration measurement at room temperature with a flow rate of 50 ml/min.
  
  
  RESULTS
  This tube successfully transformed [(11)C]CCl(4) to [(11)C]phosgene at room temperature. [(11)C]Phosgene was obtained at nearly 80% radiochemical yield (EOB) in a short synthesis time with high reproducibility.
  
  
  CONCLUSIONS
  A high yield and reliable [(11)C]phosgene production method using a gas detector tube system for working-environmental CCl(4) concentration measurement was developed.
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.
authors.forename: Masanao
authors.initials: M
authors.lastname: Ogawa
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Takada
authors.forename: Hisashi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Nemoto
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Fukumura
mesh_terms: D002250:Carbon Radioisotopes / Q000737:chemistry; D002251:Carbon Tetrachloride / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry*; D005740:Gases / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry*; D010705:Phosgene / Q000138:chemical synthesis* / Q000737:chemistry*; D015203:Reproducibility of Results; D013696:Temperature
chemical_list: D002250:Carbon Radioisotopes; D005740:Gases; D010705:Phosgene; D002251:Carbon Tetrachloride