title: Imaginal discs: Renaissance of a model for regenerative biology.
abstract: Many animals display a capacity to regenerate tissues or even a complete body. One of the main goals of regenerative biology is to identify the genes and genetic networks necessary for this process. Drosophila offers an ideal model system for such studies. The wide range of genetic and genomic approaches available for use in flies has helped in initiating the deciphering of the mechanisms underlying regeneration, and the results may be applicable to other organisms, including mammals. Moreover, most models of regeneration require experimental manipulation, whereas in Drosophila discrete domains can be ablated by genetically induced methods. Here, we present a summary of current research into imaginal disc regeneration and discuss the power of this tissue as a tool for understanding the genetics of regeneration.
authors.affiliation: Facultat de Biologia, Departament de Genètica, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
authors.forename: Cora
authors.initials: C
authors.lastname: Bergantiños
authors.affiliation: Facultat de Biologia, Departament de Genètica, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Vilana
authors.affiliation: Facultat de Biologia, Departament de Genètica, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Corominas
authors.affiliation: Facultat de Biologia, Departament de Genètica, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
authors.forename: Florenci
authors.initials: F
authors.lastname: Serras
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000502:physiology; D049109:Cell Proliferation; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000196:embryology; D004625:Embryo, Nonmammalian / Q000033:anatomy & histology / Q000502:physiology; D044127:Epigenesis, Genetic; D004848:Epithelium / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D014945:Wound Healing