title: Histomorphologic and histomorphometric evaluation of various endosseous implant healing chamber configurations at early implantation times: a study in dogs.
abstract: OBJECTIVE
  The objective of this study was to evaluate the early healing of endosseous implants presenting various healing chamber configurations in a beagle dog mandible model.
  
  
  METHODS
  The four premolars of 12 beagle dogs were extracted and allowed to heal for a period of 8 weeks. Implants allowing six different healing chamber configurations were placed in each dog (three per side, six configurations per dog). The animals were sacrificed after 3 and 5 weeks in vivo (n=6 per time in vivo), and the implants were non-decalcified processed to slides of approximately 30 microm thickness. Bone-to-implant contact (BIC) and bone area fraction occupied (BAFO) within the healing chamber were quantified. Statistical analysis was performed by a GLM ANOVA model at 5% significance level.
  
  
  RESULTS
  Osseointegration and healing with woven bone filling throughout all healing chambers was observed. Replacement of woven bone by lamellar bone showing primary osteonic structures was observed at 5 weeks. BIC was significantly affected by healing chamber configuration (P<0.001) and was not affected by time in vivo (P>0.42) at 3 and 5 weeks in vivo. BAFO was not affected by healing chamber configuration (P>0.14) however significantly increased over implantation time (P<0.001).
  
  
  CONCLUSIONS
  Regardless of healing chamber design and dimensions considered, healing allowed the devices osseointegration. However, healing chamber configuration significantly affected osseointegration measurable parameters such as BIC.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Charles
authors.initials: C
authors.lastname: Marin
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Granato
authors.forename: Marcelo
authors.initials: M
authors.lastname: Suzuki
authors.forename: Jose N
authors.initials: JN
authors.lastname: Gil
authors.forename: Malvin N
authors.initials: MN
authors.lastname: Janal
authors.forename: Paulo G
authors.initials: PG
authors.lastname: Coelho
mesh_terms: D000818:Animals; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D017267:Dental Prosthesis Design; D004285:Dogs; D016348:Osseointegration / Q000502:physiology*; D010027:Osteotomy / Q000379:methods; D013997:Time Factors; D014945:Wound Healing / Q000502:physiology
chemical_list: D015921:Dental Implants