Predictive factors of early recurrent death after a curative resection of gastric cancer.
Although several prognostic factors for gastric cancer have been shown, the predictive factors of early recurrent death remain to be elucidated. This study included 402 patients who underwent a curative resection for gastric cancer. Fifty-six patients died of recurrence. A multivariate analysis was performed to determine the independent factors correlated with survival time. The patients with an elevation of tumor markers, tumors in the upper one third of the stomach, deep wall invasion (T3, T4), extended lymph node metastases (N2, N3), an advanced stage (stages III and IV), and operation (total gastrectomy) showed a significantly different survival time. According to a multivariate analysis, the survival time was independently associated with tumor location, tumor markers, and lymph node metastases. The patients with tumors in the upper one third of the stomach, elevated tumor markers, and extended lymph node metastases can not be controlled by surgery alone.
Mikami
Koji
K
Second Department of Surgery, School of Medicine, Fukuoka University, 7-45-1, Nanakuma, Jonanku, Fukuoka 814-0180, Japan. mikamikj@fukuoka-u.ac.jp
Maekawa
Takafumi
T
Shinohara
Tetuo
T
Hoshino
Seiichiro
S
Yamauchi
Yasushi
Y
Noritomi
Tomoaki
T
Yamashita
Yuichi
Y
D014408:Biomarkers, Tumor / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D017024:Chemotherapy, Adjuvant; D005260:Female; D005743:Gastrectomy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000401:mortality; D013274:Stomach Neoplasms / Q000097:blood / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology / Q000601:surgery*
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen