title: Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation.
abstract: Mutations of nicotinamide adenine dinucleotide phosphate-dependent isocitrate dehydrogenase gene (IDH1) have been identified in patients with gliomas. Recent genome-wide screening also revealed IDH1 mutation as a recurrent event in acute myeloid leukemia (AML), but its clinical implications in AML are largely unknown. We analyzed 493 adult Chinese AML patients in Taiwan and found 27 patients (5.5%) harboring this mutation. IDH1 mutation was strongly associated with normal karyotype (8.4%, P = .002), isolated monosomy 8 (P = .043), NPM1 mutation (P < .001), and French-American-British M1 subtype (P < .001), but inversely associated with French-American-British M4 subtype (P = .030) and expression of HLA-DR, CD13, and CD14 (P = .002, .003, and .038, respectively). There was no impact of this mutation on patient survival. Sequential analysis of IDH1 mutation was performed in 130 patients during follow-ups. None of the 112 patients without IDH1 mutation at diagnosis acquired this mutation at relapse. In all 18 IDH1-mutated patients studied, the mutation disappeared in complete remission; the same mutation reappeared in all 11 samples obtained at relapse. We conclude that IDH1 is associated with distinct clinical and biologic characteristics and seems to be very stable during disease evolution.
authors.affiliation: Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
authors.forename: Wen-Chien
authors.initials: WC
authors.lastname: Chou
authors.forename: Hsin-An
authors.initials: HA
authors.lastname: Hou
authors.forename: Chien-Yuan
authors.initials: CY
authors.lastname: Chen
authors.forename: Jih-Luh
authors.initials: JL
authors.lastname: Tang
authors.forename: Ming
authors.initials: M
authors.lastname: Yao
authors.forename: Woei
authors.initials: W
authors.lastname: Tsay
authors.forename: Bor-Shen
authors.initials: BS
authors.lastname: Ko
authors.forename: Shang-Ju
authors.initials: SJ
authors.lastname: Wu
authors.forename: Shang-Yi
authors.initials: SY
authors.lastname: Huang
authors.forename: Szu-Chun
authors.initials: SC
authors.lastname: Hsu
authors.forename: Yao-Chang
authors.initials: YC
authors.lastname: Chen
authors.forename: Yen-Ning
authors.initials: YN
authors.lastname: Huang
authors.forename: Yi-Chang
authors.initials: YC
authors.lastname: Chang
authors.forename: Fen-Yu
authors.initials: FY
authors.lastname: Lee
authors.forename: Ming-Chi
authors.initials: MC
authors.lastname: Liu
authors.forename: Chia-Wen
authors.initials: CW
authors.lastname: Liu
authors.forename: Mei-Hsuan
authors.initials: MH
authors.lastname: Tseng
authors.forename: Chi-Fei
authors.initials: CF
authors.lastname: Huang
authors.forename: Hwei-Fang
authors.initials: HF
authors.lastname: Tien
mesh_terms: D000328:Adult; D000368:Aged; D018826:CD13 Antigens / Q000096:biosynthesis / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D015973:Gene Expression Regulation, Leukemic / Q000235:genetics; D055106:Genome-Wide Association Study; D006684:HLA-DR Antigens / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology / Q000235:genetics*; D018950:Lipopolysaccharide Receptors / Q000096:biosynthesis / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009006:Monosomy; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D000090243:Nucleophosmin; D012008:Recurrence; D012074:Remission Induction; D013624:Taiwan
chemical_list: D006684:HLA-DR Antigens; D018950:Lipopolysaccharide Receptors; C000716967:NPM1 protein, human; D009363:Neoplasm Proteins; D000090243:Nucleophosmin; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human; D018826:CD13 Antigens