title: Physical activity for prevention of osteoporosis in patients with severe haemophilia on long-term prophylaxis.
abstract: Physical activity has been considered as an important factor for bone density and as a factor facilitating prevention of osteoporosis. Bone density has been reported to be reduced in haemophilia. To examine the relation between different aspects of physical activity and bone mineral density (BMD) in patients with severe haemophilia on long-term prophylaxis. The study group consisted of 38 patients with severe haemophilia (mean age 30.5 years). All patients received long-term prophylaxis to prevent bleeding. The bone density (BMD g cm(-2)) of the total body, lumbar spine, total hip, femoral neck and trochanter was measured by dual energy X-ray absorptiometry. Physical activity was assessed using the self-report Modifiable Activity Questionnaire, an instrument which collects information about leisure and occupational activities for the prior 12 months. There was only significant correlation between duration and intensity of vigorous physical activity and bone density at lumber spine L1-L4; for duration (r = 0.429 and P = 0.020) and for intensity (r = 0.430 and P = 0.019); whereas no significant correlation between all aspects of physical activity and bone density at any other measured sites. With adequate long-term prophylaxis, adult patients with haemophilia are maintaining bone mass, whereas the level of physical activity in terms of intensity and duration play a minor role. These results may support the proposition that the responsiveness to mechanical strain is probably more important for bone mass development in children and during adolescence than in adults and underscores the importance of early onset prophylaxis.
authors.affiliation: Malmö Centre for Thrombosis and Haemostasis, Malmö University Hospital, Malmö, Sweden. mohammed.khawaji@med.lu.se
authors.forename: M
authors.initials: M
authors.lastname: Khawaji
authors.forename: J
authors.initials: J
authors.lastname: Astermark
authors.forename: K
authors.initials: K
authors.lastname: Akesson
authors.forename: E
authors.initials: E
authors.lastname: Berntorp
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D001779:Blood Coagulation Factors / Q000008:administration & dosage; D015519:Bone Density / Q000502:physiology*; D015444:Exercise; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology; D006467:Hemophilia A / Q000150:complications* / Q000188:drug therapy; D002836:Hemophilia B / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D010024:Osteoporosis / Q000150:complications / Q000517:prevention & control*; D013314:Stress, Mechanical; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D001779:Blood Coagulation Factors