title: [Detection of peripheral blood Th1/Th2 and Tc1/Tc2 subsets in patients with condyloma acuminatum and its significance].
abstract: OBJECTIVE
  To investigate the role of T-helper (Th) and cytotoxic T (Tc) lymphocyte polarization in the pathogenesis of condyloma acuminatum (CA) and its correlation with recurrence.
  
  
  METHODS
  Three-colour immunofluorescent flow cytometry was used to detect the proportion of CD3+ CD8- /IFN-gamma+ (Th1), CD3+ CD8- /IL-4+ (Th2), CD3+ CD8+/IFN-gamma+ (Tc1) and CD3+ CD8+ /IL-4+ (Tc2) cells in the peripheral blood of CA patients and health controls.
  
  
  RESULTS
  Compared to health controls, CA patients showed a decreased number of Th1 (P < 0.01) and Tc1 cells (P < 0.05), as well as a decreased Th1/Th2 and Tc1/Tc2 ratio (P < 0.05). Furthermore, in 15 recurrent CA patients the ratio of Th1/Th2 was remarkably decreased (P < 0.01), while the ratio of Tc1/Tc2 had no significant change in comparison with health controls.
  
  
  CONCLUSIONS
  The decrease of Th1 and Tc1 subsets results in relative Th2 and Tc2 predominance, and this tendency is more significant in recurrent CA patients. The Th1 to Th2 and Tc1 to Tc2 shifts in CA patients could be responsible for the fact that human papilloma virus (HPV) is hard to be eliminated.
authors.affiliation: Department of Dermatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Key Laboratory of Biotherapy of Zhejiang province, Hangzhou 310053, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhu
authors.forename: Hao
authors.initials: H
authors.lastname: Cheng
authors.forename: Ke-Jian
authors.initials: KJ
authors.lastname: Zhu
authors.forename: Xing
authors.initials: X
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.forename: Dong-Hai
authors.initials: DH
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003218:Condylomata Acuminata / Q000097:blood* / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology; D018417:Th1 Cells / Q000166:cytology* / Q000276:immunology; D018418:Th2 Cells / Q000166:cytology* / Q000276:immunology