title: [Genetic epidemiology--from gene to disease understanding].
abstract: Both genetic and environmental factors contribute to the aetiology of many common diseases. Recently, progress has been made in the identification of susceptibility genes by candidate gene and genome-wide association studies. Thereby, a further molecular understanding of pathophysiological pathways has been obtained and the development of new therapeutic modalities based on rational drug design has been initiated. However, a host of methods and approaches are necessary to further increase the knowledge on the aetiology of the complex diseases.
authors.affiliation: Medicinsk Afdeling, Regionshospitalet Viborg, DK-8800 Viborg, Denmark. Vibeke.andersen@viborg.rm.dk
authors.forename: Vibeke Charlotte
authors.initials: VC
authors.lastname: Andersen
authors.forename: Ulla
authors.initials: U
authors.lastname: Vogel
mesh_terms: D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D017720:Molecular Epidemiology; D010641:Phenotype