title: Small intestinal submucosa plug for closure of dilated nephrostomy tracts: a pilot study in swine.
abstract: The aim of this study was to evaluate efficacy of a plug made of small intestinal submucosa (SIS) for closure of dilated nephrostomy tract in the kidney after nephroscopy. Ten kidneys in 5 swine had nephrostomy tracts dilated up to 8 mm. The SIS plug was placed into the dilated renal cortex under nephroscopic control. Follow-up arteriograms, retrograde pyelograms, and macroscopic and histologic studies at 24 h (n = 4), 6 weeks (n = 2), and 3 months (n = 4) were performed to evaluate the efficacy of the plug. The SIS plug effectively closed the dilated nephrostomy tract. Follow-up studies showed minimal changes of the kidneys, except for 1 small infarction, regarding inflammatory and foreign-body reactions and progressive scarring of the SIS. SIS plug is effective for occlusion of dilated nephrostomy tract after nephroscopy. Its efficacy should be compared with other therapeutic options.
authors.affiliation: Dotter Interventional Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, L-342, Portland, OR 97239-3098, USA.
authors.forename: Hideyaki
authors.initials: H
authors.lastname: Kakizawa
authors.forename: M J
authors.initials: MJ
authors.lastname: Conlin
authors.forename: Dusan
authors.initials: D
authors.lastname: Pavcnik
authors.forename: Barry T
authors.initials: BT
authors.lastname: Uchida
authors.forename: Marc
authors.initials: M
authors.lastname: Loriaux
authors.forename: Young Hwan
authors.initials: YH
authors.lastname: Kim
authors.forename: Frederick S
authors.initials: FS
authors.lastname: Keller
authors.forename: Josef
authors.initials: J
authors.lastname: Rösch
mesh_terms: D000792:Angiography; D000818:Animals; D001672:Biocompatible Materials; D003094:Collagen; D004724:Endoscopy; D007413:Intestinal Mucosa / Q000637:transplantation*; D007669:Kidney Calculi / Q000601:surgery; D007672:Kidney Cortex / Q000601:surgery*; D009403:Nephrostomy, Percutaneous / Q000295:instrumentation*; D010865:Pilot Projects; D011183:Postoperative Complications / Q000517:prevention & control; D015641:Radiography, Interventional; D013552:Swine
chemical_list: D001672:Biocompatible Materials; D003094:Collagen