title: Domino access to highly substituted chromans and isochromans from carbohydrates.
abstract: Herein we describe the synthesis of highly substituted chromans and isochromans using carbohydrates as starting materials. Our approach makes use of a Pd-catalyzed domino reaction consisting of oxidative addition, followed by two carbopalladation steps and completed by a cyclization to annelate the benzene moiety. The versatility of this route has been demonstrated by a small library of highly substituted chromans and isochromans.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Göttingen, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Leibeling
authors.forename: Dennis C
authors.initials: DC
authors.lastname: Koester
authors.forename: Martin
authors.initials: M
authors.lastname: Pawliczek
authors.forename: Svenia C
authors.initials: SC
authors.lastname: Schild
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Werz