Haploidentical bone marrow transplantation in primary immune deficiency: stem cell selection and manipulation.
Since the early 1980s T-cell depletion has allowed haploidentical bone marrow transplantation to be performed in patients with primary immunodeficiency for whom a matched sibling donor was not available, without causing severe graft versus host disease (GVHD). This review article presents the available data in the literature on survival, GVHD, and immune reconstitution in different categories of patients, with special emphasis on the impact of different T-cell depletion methods.
Hagin
David
D
Department of Immunology, Weizmann Institute of Science, PO Box 26, Rehovot 76100, Israel.
Reisner
Yair
Y
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000276:immunology*; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology / Q000379:methods*; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology*; D006239:Haplotypes; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000628:therapy*; D008212:Lymphocyte Depletion / Q000379:methods*; D051379:Mice; D051381:Rats; D013234:Stem Cells / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*