A convenient microwave-enhanced solid-phase synthesis of short chain N-methyl-rich peptides.
Structural modification of the peptide backbone via N-methylation is a powerful tool to modulate the pharmacokinetic profile and biological activity of peptides. Here we describe a rapid and highly efficient microwave(MW)-assisted Fmoc/tBu solid-phase method to prepare short chain N-methyl-rich peptides, using Rink amide p-methylbenzhydrylamine (MBHA) resin as solid-phase support. This method produces peptides in high yield and purity, and reduces the time required for Fmoc-N-methyl amino acid coupling.
Rodríguez
Hortensia
H
Laboratorio de Síntesis Orgánica, Facultad de Quimica, Universidadde La Habana, 10400-Ciudad Habana, Cuba. horten@fq.uh.cu
Suarez
Margarita
M
Albericio
Fernando
F
D008745:Methylation; D008872:Microwaves; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry*
D009842:Oligopeptides