title: Optimal cutoff value of high-density lipoprotein cholesterol for predicting coronary artery disease in Taiwanese population.
abstract: The aim of this study was to determine if an optimal cutoff value for high-density lipoprotein cholesterol (HDL-C) can be obtained for predicting the risk of coronary artery disease (CAD) in Taiwanese population. We conducted a hospital-based case-control study. Patients identified by cardiac catheterization as having at least 70% stenosis of one major coronary artery and without diabetes were assigned to the case group (n = 184). The control group (n = 516) was composed of healthy individuals with normal blood biochemical values. The multiple logistic regression analysis was used to evaluate linear association between low-density lipoprotein cholesterol (LDL-C), HDL-C, or LDL-C/HDL-C ratio and CAD while adjusting for confounders. Furthermore, receiver operating characteristic curve analyses were constructed. Individuals with an HDL-C value less than or equal to 60 mg/dL had the significantly highest odds ratio (7.72; 95% confidence interval, 2.70-22.07) after adjusting for LDL-C, LDL-C/HDL-C ratio, and other potential confounders. The areas under the curves were 0.85 and 0.61 for HDL-C and LDL-C, respectively. The optimal cutoff value of HDL-C for predicting the presence of CAD was 46 mg/dL. Sensitivity and specificity using this cutoff value were 71.74% and 81.40%, respectively. Our findings suggest that subjects with lower levels of HDL-C have a much higher risk of CAD than those with higher levels of LDL-C. The optimal cutoff value for HDL-C in predicting the risk of CAD is considered as 46 mg/dL in the Taiwanese population.
authors.affiliation: School of Nutrition, Chung Shan Medical University, Taichung 402, Taiwan.
authors.forename: Yi-Chia
authors.initials: YC
authors.lastname: Huang
authors.forename: Chien-Chang
authors.initials: CC
authors.lastname: Ho
authors.forename: Ping-Ting
authors.initials: PT
authors.lastname: Lin
authors.forename: Bor-Jen
authors.initials: BJ
authors.lastname: Lee
authors.forename: Cheng-Hsiu
authors.initials: CH
authors.lastname: Lai
authors.forename: Yung-Po
authors.initials: YP
authors.lastname: Liaw
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000209:etiology*; D023921:Coronary Stenosis / Q000097:blood / Q000150:complications*; D005260:Female; D006760:Hospitalization; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012372:ROC Curve; D012016:Reference Values; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013624:Taiwan
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL