Pituitary gland: predictors of acromegaly-associated mortality.
Mortality rates are increased in acromegaly. previous studies have shown that growth hormone and insulin-like growth factor 1 levels, male gender,age, hypertension, delayed diagnosis and prior pituitary radiotherapy are independent predictors of increased mortality. A new study by Sherlock et al. now adds adrenal insufficiency and hydrocortisone replacement dose to the list of independent predictors of acromegaly-associated mortality.
Ben-Shlomo
Anat
A
Pituitary Center, Division of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Davis Building, Room 3066, Los Angeles, CA 90048, USA. benshlomoa@cshs.org
D000172:Acromegaly / Q000150:complications / Q000401:mortality* / Q000628:therapy; D000309:Adrenal Insufficiency / Q000150:complications; D005260:Female; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D006973:Hypertension / Q000150:complications; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D010902:Pituitary Gland / Q000528:radiation effects; D016634:Radiosurgery / Q000009:adverse effects; D011878:Radiotherapy / Q000009:adverse effects; D012737:Sex Factors
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D006854:Hydrocortisone