title: Use of Ankaferd Blood Stopper as a hemostatic agent: a clinical experience.
abstract: OBJECTIVE
  To determine the efficacy of the topical application of Ankaferd Blood Stopper (ABS) on hemorrhagic diathesis following dental procedures under different conditions.
  
  
  BACKGROUND
  Some patients have a tendency to bleed excessively after dental surgery for a variety of reasons, making oral surgical procedures more risky for these patients. Since hemorrhage can cause major morbidity and mortality, the identification of a novel, effective hemostatic agent could improve the management of excessive bleeding that occurs during dental procedures.
  
  
  METHODS
  Four patients (3 females, 1 male) aged 28-45 with bleeding tendencies due to different presurgical conditions such as von Willebrand Disease, chronic liver failure, and mitral valve replacement presented for tooth extraction. Hematological consultations were obtained prior to surgical intervention and their international normalized (INR) ratio values were adjusted to less than 1.5; none received clotting factor replacement. All the extractions were performed under local anesthesia with and without epinephrine. In the presence of postsurgical bleeding, the efficacy of the ampule form of topical ABS was observed. Sex, age, anamnesis, von Willebrand Factor, activated partial thromboplastin time, factor VIII, and platelet counts of patients were recorded prior to the extractions.
  
  
  CONCLUSIONS
  ABS was found to be effective within 10 to 20 minutes in controlling bleeding in most of the patients after dental surgery. These observations suggest the use of ABS may be a beneficial hemostatic agent for use in patients with hemorrhagic diathesis following tooth extraction. Additional research is needed to clarify the role of this unique medicinal product in the surgical treatment of dental patients with bleeding tendency.
  
  
  CONCLUSIONS
  ABS has demonstrated potential for being an effective hemostatic agent for the treatment of excessive bleeding following dental surgery in four patients with hemorrhagic diathesis.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Suleyman Demirel, Isparta, Turkey. timucinbaykul@yahoo.com
authors.forename: Timucin
authors.initials: T
authors.lastname: Baykul
authors.forename: E Guchan
authors.initials: EG
authors.lastname: Alanoglu
authors.forename: Gulperi
authors.initials: G
authors.lastname: Kocer
mesh_terms: D000328:Adult; D032429:Alpinia; D017742:Dental Care for Chronically Ill; D005260:Female; D006035:Glycyrrhiza; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D006472:Oral Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D046930:Thymus Plant; D014081:Tooth Extraction / Q000009:adverse effects*; D026982:Urtica dioica; D027843:Vitis; D014859:Warfarin; D014842:von Willebrand Diseases / Q000150:complications
chemical_list: D006490:Hemostatics; D010936:Plant Extracts; C539751:ankaferd blood stopper; D014859:Warfarin