title: Plant antimicrobial agents and their effects on plant and human pathogens.
abstract: To protect themselves, plants accumulate an armoury of antimicrobial secondary metabolites. Some metabolites represent constitutive chemical barriers to microbial attack (phytoanticipins) and others inducible antimicrobials (phytoalexins). They are extensively studied as promising plant and human disease-controlling agents. This review discusses the bioactivity of several phytoalexins and phytoanticipins defending plants against fungal and bacterial aggressors and those with antibacterial activities against pathogens affecting humans such as Pseudomonas aeruginosa and Staphylococcus aureus involved in respiratory infections of cystic fibrosis patients. The utility of plant products as "antibiotic potentiators" and "virulence attenuators" is also described as well as some biotechnological applications in phytoprotection.
authors.affiliation: Département de Biologie, Faculté de Sciences, Université de Sherbrooke, 2500 Boulevard de l'Uni-versité, Sherbrooke, Québec J1K 2R1, Canada.
authors.forename: Rocío
authors.initials: R
authors.lastname: González-Lamothe
authors.affiliation: Département de Biologie, Faculté de Sciences, Université de Sherbrooke, 2500 Boulevard de l'Uni-versité, Sherbrooke, Québec J1K 2R1, Canada.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Mitchell
authors.affiliation: Département de Biologie, Faculté de Sciences, Université de Sherbrooke, 2500 Boulevard de l'Uni-versité, Sherbrooke, Québec J1K 2R1, Canada.
authors.forename: Mariza
authors.initials: M
authors.lastname: Gattuso
authors.affiliation: Pacific Agri-Food Research Centre, Agriculture and Agri-Food Canada, P.O. Box 1000, Agassiz, BC V0M 1A0, Canada.
authors.forename: Moussa S
authors.identifier: 0000-0003-2966-345X
authors.initials: MS
authors.lastname: Diarra
authors.affiliation: Département de Biologie, Faculté de Sciences, Université de Sherbrooke, 2500 Boulevard de l'Uni-versité, Sherbrooke, Québec J1K 2R1, Canada.
authors.forename: François
authors.initials: F
authors.lastname: Malouin
authors.affiliation: Département de Biologie, Faculté de Sciences, Université de Sherbrooke, 2500 Boulevard de l'Uni-versité, Sherbrooke, Québec J1K 2R1, Canada.
authors.forename: Kamal
authors.initials: K
authors.lastname: Bouarab
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D010944:Plants / Q000737:chemistry* / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D000094162:Phytoalexins
chemical_list: D000890:Anti-Infective Agents; D012503:Saponins; D012717:Sesquiterpenes; D000094162:Phytoalexins