title: Haemolytic anaemia caused by piperacillin-tazobactam.
abstract: We report a case of haemolytic due to the use of piperacillin-tazobactam in a 50-year-old woman. Since 2002 4 other cases were reported. Either the presence of piperacillin as tazobactam can induce haemolysis. In all cases discontinuating the drugs resolves the haemolysis. Although drug-induced haemolytic anaemia due to piperacillin-tazobactam is rare, the common use of this antibioticum in the critical care setting should alert the physician as a possible culprit in cases of haemolytic anaemia.
authors.affiliation: Intensive Care Unit, AZ Monica, Antwerpen, Belgium. drDapper@azmonica.be
authors.forename: I
authors.initials: I
authors.lastname: Dapper
authors.forename: M
authors.initials: M
authors.lastname: Nauwynck
authors.forename: D
authors.initials: D
authors.lastname: Selleslag
authors.forename: M
authors.initials: M
authors.lastname: Hidajat
authors.forename: M
authors.initials: M
authors.lastname: Bourgeois
authors.forename: P
authors.initials: P
authors.lastname: Martens
authors.forename: A
authors.initials: A
authors.lastname: Wilmer
mesh_terms: D000743:Anemia, Hemolytic / Q000139:chemically induced*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001803:Blood Transfusion; D005260:Female; D006801:Humans; D008875:Middle Aged; D010397:Penicillanic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D010878:Piperacillin / Q000009:adverse effects; D000077725:Piperacillin, Tazobactam Drug Combination
chemical_list: D000900:Anti-Bacterial Agents; D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D010878:Piperacillin