Extrusion-spheronisation of microcrystalline cellulose pastes using a non-aqueous liquid binder.
An experimental investigation of extrusion-spheronisation (E-S) of a novel microcrystalline cellulose (MCC) formulation, comprising dimethyl sulfoxide (DMSO) as the granulating liquid, is reported. The extrusion-spheronisation performance of DMSO/MCC pastes is compared to that of similar water/MCC formulations and their rheological behaviours similarly assessed using lubricated squeeze flow. A case study involving water, DMSO and anhydrous ethanol yields important information regarding the physico-chemical properties necessary for solvents to be suitable for the extrusion of MCC.
Mascia
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Department of Chemical Engineering and Biotechnology, New Museums Site, Pembroke Street, Cambridge, CB2 3RA, UK.
Seiler
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Fitzpatrick
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Wilson
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D002482:Cellulose / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D000431:Ethanol / Q000737:chemistry; D005079:Excipients / Q000737:chemistry*; D012212:Rheology; D012997:Solvents / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods; D014867:Water / Q000737:chemistry
D005079:Excipients; D012997:Solvents; D014867:Water; D000431:Ethanol; D002482:Cellulose; C109691:microcrystalline cellulose; D004121:Dimethyl Sulfoxide