title: Attachment style, affective loss and gray matter volume: a voxel-based morphometry study.
abstract: Early patterns of infant attachment have been shown to be an important influence on adult social behavior. Animal studies suggest that patterns of early attachment influence brain development, contributing to permanent alterations in neural structure; however, there are no previous studies investigating whether differences in attachment style are associated with differences in brain structure in humans. In this study, we used Magnetic Resonance Imaging (MRI) and voxel-based morphometry (VBM) to examine for the first time the association between attachment style, affective loss (for example, death of a loved one) and gray matter volume in a healthy sample of adults (n = 32). Attachment style was assessed on two dimensions (anxious and avoidant) using the ECR-Revised questionnaire. High attachment-related anxiety was associated with decreased gray matter in the anterior temporal pole and increased gray matter in the left lateral orbital gyrus. A greater number of affective losses was associated with increased gray matter volume in the cerebellum; in this region, however, the impact of affective losses was significantly moderated by the level of attachment-related avoidance. These findings indicate that differences in attachment style are associated with differences in the neural structure of regions implicated in emotion regulation. It is hypothesized that early attachment experience may contribute to structural brain differences associated with attachment style in adulthood; furthermore, these findings point to a neuronal mechanism through which attachment style may mediate individual differences in responses to affective loss.
authors.affiliation: Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King's College London, London SE5 8AF, United Kingdom.
authors.forename: Stefania
authors.initials: S
authors.lastname: Benetti
authors.forename: Eamon
authors.initials: E
authors.lastname: McCrory
authors.forename: Sobida
authors.initials: S
authors.lastname: Arulanantham
authors.forename: Teresa
authors.initials: T
authors.lastname: De Sanctis
authors.forename: Philip
authors.initials: P
authors.lastname: McGuire
authors.forename: Andrea
authors.initials: A
authors.lastname: Mechelli
mesh_terms: D000328:Adult; D001284:Atrophy; D001921:Brain / Q000473:pathology* / Q000502:physiology; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000473:pathology* / Q000502:physiology; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009769:Object Attachment; D055815:Young Adult