title: Thrombocytopenia, an important interfering factor of antiviral therapy and hepatocellular carcinoma treatment for chronic liver diseases.
abstract: In patients with chronic liver diseases, thrombocytopenia is a common manifestation which interferes with antiviral therapy for hepatitis C virus (HCV), and with hepatocellular carcinoma (HCC) treatment. While thrombopoietin-receptor agonist is expected to improve thrombocytopenia for patients with chronic liver diseases in 2-3 weeks, there is still a lack of fundamental data about short-term variations in the natural course of platelet count in cirrhotic patients, and the impact of thrombocytopenia on antiviral therapy for HCV-infected patients and patients being treated for HCC. The aims of this study are to investigate sequential changes in platelet count and the impact of thrombocytopenia on antiviral therapy and HCC treatment in patients with chronic liver diseases. A total of 726 chronic liver disease patients were enrolled in this study. Changes of platelet count were examined during a 4-week follow-up. Risk of discontinuation or reduction of peginterferon dosage was evaluated in HCV patients with moderate thrombocytopenia (5-10x10(4)/microL). Risk of platelet transfusion or splenectomy was evaluated in HCC patients with severe thrombocytopenia (<5x10(4)/microL). No significant changes of platelet count were observed in cirrhotic patients with thrombocytopenia during a 4-week follow-up. The rate of discontinuation or reduction in dosage of peginterferon was 85.2% (23/27) in patients with moderate thrombocytopenia. Risk of discontinuation or reduction of peginterferon dosage was 3.4-times higher in HCV patients with thrombocytopenia than in those without thrombocytopenia. In HCC patients with severe thrombocytopenia, the frequency of platelet transfusion or splenectomy during HCC treatment was 57.9% (22/38). Risk of platelet transfusion or splenectomy in HCC patients with thrombocytopenia was 57.9-times higher than in those without thrombocytopenia. In conclusion, we demonstrated no significant variation in the short-term natural course of platelet count in cirrhotic patients. In chronic liver disease patients with moderate and severe thrombocytopenia, about 85% of patients treated with peginterferon, and 60% of patients receiving HCC treatments suffered from thrombocytopenia-related limitations, respectively.
authors.affiliation: Department of Digestive Disease Information & Research, Kurume University School of Medicine, Asahi-machi, Kurume, Japan. takumi@med.kurume-u.ac.jp
authors.forename: Takumi
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: Ryoko
authors.initials: R
authors.lastname: Kuromatsu
authors.forename: Ryoko
authors.initials: R
authors.lastname: Kurumatsu
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ide
authors.forename: Eitaro
authors.initials: E
authors.lastname: Taniguchi
authors.forename: Minoru
authors.initials: M
authors.lastname: Itou
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sakata
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Abe
authors.forename: Shuji
authors.initials: S
authors.lastname: Sumie
authors.forename: Michio
authors.initials: M
authors.lastname: Sata
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000628:therapy*; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D013921:Thrombocytopenia / Q000150:complications*