Randomized comparison of OASIS wound matrix versus moist wound dressing in the treatment of difficult-to-heal wounds of mixed arterial/venous etiology.
OBJECTIVE
In this study, a biological extracellular matrix was compared with a moist wound dressing to determine its effectiveness in the treatment of mixed arterial/venous and venous ulcers.


METHODS
Patients were evaluated for complete wound healing, time to dressing change, and formation of granulation tissue.


RESULTS
Extracellular matrix-treated ulcers achieved complete healing on average in 5.4 weeks as compared with 8.3 weeks for the control group treated with moist wound dressing (P = .02). At the primary time point evaluated (8 weeks), complete wound closure was achieved in 80% of extracellular matrix-treated ulcers compared with 65% of ulcers in the control group (P < .05). Statistically significant differences favoring the extracellular-matrix treatment group were also reported for time to dressing change (P < .05), and for percentage of granulation tissue formed (P < .05).


CONCLUSIONS
Overall, the biological extracellular matrix was more beneficial than moist wound dressings for the treatment of patients with mixed arterial/venous or venous ulcers.
Romanelli
Marco
M
Department of Dermatology, University of Pisa, Italy.
Dini
Valentina
V
Bertone
Maria Stefania
MS
D000818:Animals; D001684:Biological Dressings; D005109:Extracellular Matrix; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology / Q000628:therapy*; D008297:Male; D011446:Prospective Studies; D013552:Swine; D014945:Wound Healing; D014947:Wounds and Injuries / Q000209:etiology / Q000628:therapy*