title: Comparison of the duration of antimicrobial activity of 2 different antimicrobial central venous catheters.
abstract: We compared the duration of antimicrobial effectiveness of 2 different antimicrobial catheters. The baseline activity of minocycline-rifampin catheters was greater than that of silver-platinum-carbon catheters against Staphylococcus aureus, Staphylococcus epidermidis, and Enterococcus faecalis. The antimicrobial activity of the minocycline-rifampin catheters against these pathogens persisted for up to 12 days, while that of the silver-platinum-carbon catheters was depleted by day 10 (P < .05).
authors.affiliation: Department of Anesthesiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
authors.forename: Theofilos
authors.initials: T
authors.lastname: Matheos
authors.forename: J Matthias
authors.initials: JM
authors.lastname: Walz
authors.forename: Janice P
authors.initials: JP
authors.lastname: Adams
authors.forename: Karen
authors.initials: K
authors.lastname: Johnson
authors.forename: Karen
authors.initials: K
authors.lastname: Longtine
authors.forename: Jaclyn
authors.initials: J
authors.lastname: Longtine
authors.forename: Melissa
authors.initials: M
authors.lastname: O'Neill
authors.forename: Stephen O
authors.initials: SO
authors.lastname: Heard
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D001422:Bacterial Adhesion / Q000187:drug effects; D002405:Catheterization, Central Venous / Q000009:adverse effects / Q000295:instrumentation*; D002408:Catheters, Indwelling / Q000382:microbiology*; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D008404:Massachusetts; D008911:Minocycline / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D008911:Minocycline; D012293:Rifampin