Improved synthesis of the two-photon caging group 3-nitro-2-ethyldibenzofuran and its application to a caged thymidine phosphoramidite.
A new and efficient route to the recently reported 3-nitro-2-ethyldibenzofuran caging group was developed. Furthermore, its installation on a thymidine phosphoramidite is described. This caging group is efficiently removed through light-irradiation at 365 nm.
Lusic
Hrvoje
H
Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA.
Uprety
Rajendra
R
Deiters
Alexander
A
D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry*; D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry*; D017785:Photons; D013938:Thymidine Monophosphate / Q000031:analogs & derivatives* / Q000737:chemistry*
D001572:Benzofurans; D009943:Organophosphorus Compounds; C434331:phosphoramidite; D013938:Thymidine Monophosphate; D004247:DNA; C105430:benzofuran