Acute immune response to Mycobacterium massiliense in C57BL/6 and BALB/c mice.
Mycobacterium massiliense is an environmental opportunistic pathogen that has been associated with soft tissue infection after minor surgery. We studied the acute immune response of C57BL/6 and BALB/c mice infected intravenously with 10(6) CFU of an M. massiliense strain isolated from a nosocomial infection in Brazil. The results presented here show that M. massiliense is virulent and pathogenic to both C57BL/6 and BALB/c mice, inducing a granulomatous inflammatory reaction that involves the activation of macrophages, dendritic cells, and natural killer cells induced by gamma interferon and interleukin-17 (IL-17) in C57BL/6 mice and by IL-12 in BALB/c mice.
Martins de Sousa
Eduardo
E
Departamento de Microbiologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia-Go, Brazil.
Bonfim de Bortoli
Fernando
F
Amaral
Eduardo Pinheiro
EP
Batista
Aline Carvalho
AC
Liberman Kipnis
Thereza
T
Marques Cardoso
Alessandra
A
Kipnis
André
A
Junqueira-Kipnis
Ana Paula
AP
D000818:Animals; D016470:Bacteremia / Q000276:immunology / Q000473:pathology; D001938:Brazil; D003428:Cross Infection / Q000382:microbiology; D003713:Dendritic Cells / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D006099:Granuloma / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology; D020381:Interleukin-17 / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009161:Mycobacterium / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity*; D009164:Mycobacterium Infections / Q000276:immunology* / Q000382:microbiology / Q000473:pathology*; D013154:Spleen / Q000382:microbiology / Q000473:pathology; D014774:Virulence
D020381:Interleukin-17; D007371:Interferon-gamma