The intriguing links between prominin-1 (CD133), cholesterol-based membrane microdomains, remodeling of apical plasma membrane protrusions, extracellular membrane particles, and (neuro)epithelial cell differentiation.
Prominin-1 (CD133) is a cholesterol-interacting pentaspan membrane protein concentrated in plasma membrane protrusions. In epithelial cells, notably neuroepithelial stem cells, prominin-1 is found in microvilli, the primary cilium and the midbody. These three types of apical membrane protrusions are subject to remodeling during (neuro)epithelial cell differentiation. The protrusion-specific localization of prominin involves its association with a distinct cholesterol-based membrane microdomain. Moreover, the three prominin-1-containing plasma membrane protrusions are the origin of at least two major subpopulations of prominin-1-containing extracellular membrane particles. Intriguingly, the release of these particles has been implicated in (neuro)epithelial cell differentiation.
Corbeil
Denis
D
Tissue Engineering Laboratories, BIOTEC, Technische Universität Dresden, Dresden, Germany.
Marzesco
Anne-Marie
AM
Wilsch-Bräuninger
Michaela
M
Huttner
Wieland B
WB
D000071916:AC133 Antigen; D000818:Animals; D015703:Antigens, CD / Q000737:chemistry / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D022081:Cell Surface Extensions / Q000737:chemistry / Q000378:metabolism*; D055252:Cell-Derived Microparticles / Q000378:metabolism* / Q000502:physiology; D002784:Cholesterol / Q000737:chemistry / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism / Q000502:physiology*; D005110:Extracellular Space / Q000378:metabolism; D006023:Glycoproteins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D021962:Membrane Microdomains / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D010455:Peptides / Q000737:chemistry / Q000502:physiology*
D000071916:AC133 Antigen; D015703:Antigens, CD; D006023:Glycoproteins; C000606023:PROM1 protein, human; D010455:Peptides; D002784:Cholesterol