Flavanone and diphenylpropane glycosides and glycosidic acyl esters from Viscum articulatum.
Seven new compounds including three flavanone glycosides, visartisides A-C (1-3), three glycoside acyl esters, visartisides D-F (4-6), and one diphenylpropane glycoside, (4'-hydroxy-2',3',6',3''-tetramethoxy-1,3-diphenylpropane)-4''-O-beta-d-glucopyranoside (7), along with four known flavanone glycosides (8-11) were isolated from the leaves and stems of Viscum articulatum. The structure elucidation of 1-7 was based on spectroscopic data analysis. Biological evaluation showed that 1, 2, and 10 exhibited antioxidant activity using a DPPH method and that compounds 1, 3, and 11 were active in a lipopolysaccharide-induced nitric oxide assay.
Kuo
Yu-Jen
YJ
Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China. kuoyh@nricm.edu.tw
Yang
Yu-Ching
YC
Zhang
Li-Jie
LJ
Wu
Ming-Der
MD
Kuo
Li-Ming Yang
LM
Kuo
Yuh-Chi
YC
Hwang
Syh-Yuan
SY
Chou
Cheng-Jen
CJ
Lee
Kuo-Hsiung
KH
Ho
Hsiu-O
HO
Kuo
Yao-Haur
YH
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000494:pharmacology; D004952:Esters; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009417:Nerve Tissue / Q000166:cytology / Q000187:drug effects; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D010851:Picrates / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D013624:Taiwan; D028181:Viscum / Q000737:chemistry*
D000975:Antioxidants; D001713:Biphenyl Compounds; D004952:Esters; D044950:Flavanones; D006027:Glycosides; D008070:Lipopolysaccharides; D010851:Picrates; D009569:Nitric Oxide; C004931:1,1-diphenyl-2-picrylhydrazyl; C028610:flavanone