Joint effects of hypertension, smoking, dyslipidemia and obesity and angiotensin-converting enzyme DD genotype on albuminuria in Taiwanese patients with type 2 diabetes mellitus.
OBJECTIVE
We investigated the individual and joint effects of hypertension, smoking, dyslipidemia, and obesity and angiotensin-converting enzyme (ACE) DD genotype on albuminuria in Taiwanese type 2 diabetic patients.


METHODS
ACE genotypes were determined in 519 (287 men and 232 women) patients aged 58.5 (SD: 9.0) years. Among them, 240 had albuminuria (urinary albumin-to-creatinine ratio > or =30 microg/mg). Logistic regression was used to evaluate the individual and joint effects of risk factors and DD classified by two-by-four table.


RESULTS
The adjusted odds ratios were significant for hypertension, smoking and obesity but not for DD and dyslipidemia in models evaluating individual effects. However, while analyzing the joint effects of DD and hypertension, smoking, dyslipidemia and obesity, the respective adjusted odds ratios were 3.253 (1.261-8.391), 3.016 (1.086-8.376), 2.385 (1.010-5.630) and 2.508 (1.117-5.631).


CONCLUSIONS
Hypertension, smoking, dyslipidemia and obesity jointly play an important role with DD genotype in mediating albuminuria.
Tseng
Chin-Hsiao
CH
National Taiwan University College of Medicine, Taipei, Taiwan. ccktsh@ms6.hinet.net
Tseng
Ching-Ping
CP
Chong
Choon-Khim
CK
D000368:Aged; D000419:Albuminuria / Q000209:etiology / Q000235:genetics*; D044466:Asian People; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics; D050171:Dyslipidemias / Q000150:complications* / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000453:epidemiology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology; D013624:Taiwan / Q000453:epidemiology
D007703:Peptidyl-Dipeptidase A