title: Interfacing live cells with nanocarbon substrates.
abstract: Nanocarbon materials, including single-walled carbon nanotubes (SWCNTs) and graphene, promise various novel biomedical applications (e.g., nanoelectronic biosensing). In this Letter, we study the ability of SWCNT networks and reduced graphene oxide (rGO) films in interfacing several types of cells, such as neuroendocrine PC12 cells, oligodendroglia cells, and osteoblasts. It was found that rGO is biocompatible with all these cell types, whereas the SWCNT network is inhibitory to the proliferation, viability, and neuritegenesis of PC12 cells, and the proliferation of osteoblasts. These observations could be attributed to the distinct nanotopographic features of these two kinds of nanocarbon substrates.
authors.affiliation: School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457.
authors.forename: Shuchi
authors.initials: S
authors.lastname: Agarwal
authors.forename: Xiaozhu
authors.initials: X
authors.lastname: Zhou
authors.forename: Feng
authors.initials: F
authors.lastname: Ye
authors.forename: Qiyuan
authors.initials: Q
authors.lastname: He
authors.forename: George C K
authors.initials: GC
authors.lastname: Chen
authors.forename: Jianchow
authors.initials: J
authors.lastname: Soo
authors.forename: Freddy
authors.initials: F
authors.lastname: Boey
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D006108:Graphite / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D037742:Nanotubes, Carbon / Q000737:chemistry*; D016501:Neurites / Q000187:drug effects; D009836:Oligodendroglia / Q000166:cytology*; D010006:Osteoblasts / Q000166:cytology*; D016716:PC12 Cells; D010316:Particle Size; D051381:Rats; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D037742:Nanotubes, Carbon; D006108:Graphite