title: Decomposition of two-component ultrasound pulses in cancellous bone using modified least squares prony method--phantom experiment and simulation.
abstract: Porous media such as cancellous bone often support the simultaneous propagation of two compressional waves. When small bone samples are interrogated in through-transmission with broadband sources, these two waves often overlap in time. The modified least-squares Prony's (MLSP) method was tested for decomposing a 500 kHz-center-frequency signal containing two overlapping components: one passing through a polycarbonate plate (to produce the "fast" wave) and another passing through a cancellous-bone-mimicking phantom (to produce the "slow" wave). The MLSP method yielded estimates of attenuation slopes accurate to within 7% (polycarbonate plate) and 2% (cancellous bone phantom). The MLSP method yielded estimates of phase velocities accurate to within 1.5% (both media). The MLSP method was also tested on simulated data generated using attenuation slopes and phase velocities corresponding to bovine cancellous bone. Throughout broad ranges of signal-to-noise ratio (SNR), the MLSP method yielded estimates of attenuation slope that were accurate to within 1.0% and estimates of phase velocity that were accurate to within 4.3% (fast wave) and 1.3% (slow wave).
authors.affiliation: Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA. keith.wear@fda.hhs.gov
authors.forename: Keith A
authors.initials: KA
authors.lastname: Wear
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002417:Cattle; D054459:Elasticity Imaging Techniques / Q000379:methods; D016018:Least-Squares Analysis; D019047:Phantoms, Imaging; D016062:Porosity; D012815:Signal Processing, Computer-Assisted