Utility of the WHO-Five Well-being Index as a screening tool for depression in Parkinson's disease.
Beck depression inventory (BDI-1A) is the gold standard screening tool for Parkinson's disease (PD) depression, but as a result of its complexity, it is of limited suitability as a quick and easy screening device. We, therefore, validate the 5-item WHO-Five Well-being Index (WHO-5) as a screening tool for PD depression. Two hundred thirteen of 215 recruited PD patients (99.1%) completed the WHO-5. Receiver operating characteristic plots were used to calculate sensitivity/specificity for all cut-off scores for the detection of depression and combined depression/dysthymia as assessed by an independent investigator using the Mini International Neuropsychiatric Interview (MINI). Internal consistency of the WHO-5 was good (Cronbach's alpha = 0.83). WHO-5 showed high validity with adequate detection of depression without differences in the validity indices compared to BDI-1A (P = 0.234). The optimal cut-off value for detection of depression was 12 of 13 points. WHO-5 is a useful, brief, and easy instrument for identifying PD subjects with depression in daily practice.
Schneider
Christine B
CB
Department of Neurology, Dresden University of Technology, Dresden, Germany.
Pilhatsch
Maximilian
M
Rifati
Martina
M
Jost
Wolfgang H
WH
Wodarz
Franziska
F
Ebersbach
Georg
G
Djundja
Daniela
D
Fuchs
Gerd
G
Gies
Arne
A
Odin
Per
P
Reifschneider
Gerd
G
Wolz
Martin
M
Bottesi
Antonia
A
Bauer
Michael
M
Reichmann
Heinz
H
Storch
Alexander
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003863:Depression / Q000175:diagnosis* / Q000209:etiology / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000523:psychology*; D011569:Psychiatric Status Rating Scales / Q000592:standards; D011594:Psychometrics; D015203:Reproducibility of Results; D014944:World Health Organization