title: An experimental study for evaluating the efficacy of cercarial vaccine against Schistosoma mansoni.
abstract: This study assessed the effectiveness of autoclaved cercarial vaccine (ACV) in protection against Schistosoma mansoni infection in 125 Swiss albino mice classified into two main groups: GI: a control group. GII: a test vaccinated with ACV, in a single dose of 0.1 ml of 10(4) ml ACV (G.IIa), double dose; 0.2ml (G.IIb) and two single doses 2 weeks apart (G.IIc). Four weeks later, all mice were challenged with S. mansoni cercariae and sacrificed 10 weeks post infection (P.I.). The results revealed that the vaccine in a single dose (G.IIa) induced a high level of protection against S. mansoni infection. There was a significant reduction in the mean number of adult worm (91.12%), ova/gram liver (91.87%), ova/gram intestine (89.09%) and number & size of granulomas in liver (92.92% & 43.53% respectively). Besides, ACV induced a significant increase in the level of IL-10 mRNA expression as compared to the control group.
authors.affiliation: Department of Parasitology, Faculty of Medicine, Tanta University, Egypt.
authors.forename: Sirria M
authors.initials: SM
authors.lastname: El-Marhoumy
authors.forename: Kholoud A
authors.initials: KA
authors.lastname: El-Nouby
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Emara
authors.forename: Dina M
authors.initials: DM
authors.lastname: Abou Rayia
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis*; D004306:Dose-Response Relationship, Immunologic; D008297:Male; D051379:Mice; D010270:Parasite Egg Count; D011897:Random Allocation; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D016896:Treatment Outcome; D014611:Vaccination; D015164:Vaccines, Inactivated / Q000276:immunology
chemical_list: D000909:Antibodies, Helminth; D015164:Vaccines, Inactivated