Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease.
Cholesterol has been implicated in various neurodegenerative diseases. Here we review the connection between cholesterol and Alzheimer's disease (AD), focusing on a recent study that links neuronal cholesterol esterification with biosynthesis of 24(S)-hydroxycholesterol and the fate of human amyloid precursor protein in a mouse model of AD. We also briefly evaluate the potential of ACAT1 as a drug target for AD.
Chang
Ta-Yuan
TY
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA. ta.yuan.chang@dartmouth.edu
Chang
Catherine C Y
CC
Bryleva
Elena
E
Rogers
Maximillian A
MA
Murphy
Stephanie R
SR
D000544:Alzheimer Disease / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D004951:Esterification; D006801:Humans; D006888:Hydroxycholesterols / Q000378:metabolism*; D050356:Lipid Metabolism; D051379:Mice; D019636:Neurodegenerative Diseases / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D012306:Risk
D016564:Amyloid beta-Protein Precursor; D006888:Hydroxycholesterols; D002784:Cholesterol