title: Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia.
abstract: Improved treatment of childhood acute lymphoblastic leukemia (ALL) depends on the identification of new molecular markers that are able to predict treatment response and clinical outcome. The development of impaired apoptosis in leukemic cells is one factor that may influence their response to treatment. We investigated the expression of three apoptosis related genes, BCL2L13, CASP8AP2, and Livin, as well as their prognostic significance, in a retrospective study of 90 pediatric ALL patients diagnosed between 1996 and 2007 in Taiwan. Univariant analysis revealed that high expression of BCL2L13 was associated with inferior event-free survival and overall survival (p<0.001 and 0.005, respectively). Multivariate analysis for EFS and OS demonstrated that high expression of BCL2L13 was an independent prognostic factor for childhood ALL in this ethnic group.
authors.affiliation: Department of Laboratory Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Yung-Li
authors.initials: YL
authors.lastname: Yang
authors.forename: Shu-Rung
authors.initials: SR
authors.lastname: Lin
authors.forename: Jiann-Shiuh
authors.initials: JS
authors.lastname: Chen
authors.forename: Shu-Wha
authors.initials: SW
authors.lastname: Lin
authors.forename: Sung-Liang
authors.initials: SL
authors.lastname: Yu
authors.forename: Hsuan-Yu
authors.initials: HY
authors.lastname: Chen
authors.forename: Ching-Tzu
authors.initials: CT
authors.lastname: Yen
authors.forename: Chien-Yu
authors.initials: CY
authors.lastname: Lin
authors.forename: Jing-Fang
authors.initials: JF
authors.lastname: Lin
authors.forename: Kai-Hsin
authors.initials: KH
authors.lastname: Lin
authors.forename: Shiann-Tarng
authors.initials: ST
authors.lastname: Jou
authors.forename: Chung-Yi
authors.initials: CY
authors.lastname: Hu
authors.forename: Sheng-Kai
authors.initials: SK
authors.lastname: Chang
authors.forename: Meng-Yao
authors.initials: MY
authors.lastname: Lu
authors.forename: Hsiu-Hao
authors.initials: HH
authors.lastname: Chang
authors.forename: Wan-Hui
authors.initials: WH
authors.lastname: Chang
authors.forename: Kuo-Sin
authors.initials: KS
authors.lastname: Lin
authors.forename: Dong-Tsamn
authors.initials: DT
authors.lastname: Lin
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000293:Adolescent; D017209:Apoptosis / Q000235:genetics*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D016016:Proportional Hazards Models; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; C431152:BCL2L13 protein, human; C419866:BIRC7 protein, human; C485604:CASP8AP2 protein, human; D002135:Calcium-Binding Proteins; D051034:Inhibitor of Apoptosis Proteins; D009363:Neoplasm Proteins; D019253:Proto-Oncogene Proteins c-bcl-2