title: Regulation of immune cell responses by semaphorins and their receptors.
abstract: Semaphorins were originally identified as axon guidance factors involved in the development of the neuronal system. However, accumulating evidence indicates that several members of semaphorins, so-called 'immune semaphorins', are crucially involved in various phases of immune responses. These semaphorins regulate both immune cell interactions and immune cell trafficking during physiological and pathological immune responses. Here, we review the following two functional aspects of semaphorins and their receptors in immune responses: their functions in cell-cell interactions and their involvement in immune cell trafficking.
authors.affiliation: Department of Immunopathology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
authors.forename: Hyota
authors.initials: H
authors.lastname: Takamatsu
authors.forename: Tatsusada
authors.initials: T
authors.lastname: Okuno
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kumanogoh
mesh_terms: D000818:Animals; D002450:Cell Communication; D002465:Cell Movement; D006801:Humans; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000276:immunology* / Q000378:metabolism*; D039961:Semaphorins / Q000276:immunology* / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface; D039961:Semaphorins