Pupylation versus ubiquitylation: tagging for proteasome-dependent degradation.
Prokaryotic ubiquitin-like protein (Pup) is the first identified prokaryotic protein that is functionally analogous to ubiquitin. Despite using the proteasome as the end-point for proteolysis, Pup differs from ubiquitin both biochemically and structurally. We will discuss these differences that have been highlighted by several recent studies. Finally, we will speculate on the possible interactions between the two analogous pathways in pathogen and host.
Burns
Kristin E
KE
Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA. kristin.burns@nyumc.org
Darwin
K Heran
KH
D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D054875:Ubiquitination
D001426:Bacterial Proteins; D046988:Proteasome Endopeptidase Complex