Therapeutic strategies underpinning the development of novel techniques for the treatment of HIV infection.
The HIV replication cycle offers multiple targets for chemotherapeutic intervention, including the viral exterior envelope glycoprotein, gp120; viral co-receptors CXCR4 and CCR5; transmembrane glycoprotein, gp41; integrase; reverse transcriptase; protease and so on. Most currently used anti-HIV drugs are reverse transcriptase inhibitors or protease inhibitors. The expanding application of simulation to drug design combined with experimental techniques have developed a large amount of novel inhibitors that interact specifically with targets besides transcriptase and protease. This review presents details of the anti-HIV inhibitors discovered with computer-aided approaches and provides an overview of the recent five-year achievements in the treatment of HIV infection and the application of computational methods to current drug design.
Tan
Jian J
JJ
College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, China.
Cong
Xiao J
XJ
Hu
Li M
LM
Wang
Cun X
CX
Jia
Lee
L
Liang
Xing-Jie
XJ
D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000627:therapeutic use*; D019468:Disease Management; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D006801:Humans
D019380:Anti-HIV Agents