Isolation of C11 cyclopentenones from two didemnid species, Lissoclinum sp. and Diplosoma sp.
A series of new C(11) cyclopentenones 1-7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8-12. The structures of 1-7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).
Ogi
Takayuki
T
Department of Chemistry, Biology and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa, Japan. ogitkyuk@pref.okinawa.lg.jp
Margiastuti
Palupi
P
Teruya
Toshiaki
T
Taira
Junsei
J
Suenaga
Kiyotake
K
Ueda
Katsuhiro
K
D000818:Animals; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D003517:Cyclopentanes / Q000737:chemistry* / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship; D014561:Urochordata / Q000737:chemistry*
D003517:Cyclopentanes; C013905:cyclopentenone