Congenital pigment synthesizing melanoma of the scalp.
The pigment synthesizing melanoma, so-called animal type melanoma, is a rare variant of melanoma that is characterized by prominent melanin production and an unpredictable prognosis. Congenital onset of this melanoma is exceedingly rare. A 2-month-old Korean girl had a black nodule and a satellite black macule on the scalp which were noticed at birth. She received a surgical resection 3 months later because of rapidly growing lesions and the histopathologic features of a pigment synthesizing melanoma. Two months later, she returned with cervical area swelling, and the excised multiple lymph nodes showed metastatic malignant melanoma. The exact origin and pathogenesis of congenital pigment synthesizing melanoma is different from the more common forms of melanoma and remains poorly understood.
Yun
Sook Jung
SJ
Department of Dermatology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School and Center for Biomedical Human Resources, Gwangju, Korea.
Han
Dong Kyun
DK
Lee
Min-Cheol
MC
Lee
Jee-Bum
JB
Baek
Hee Jo
HJ
Bae
Si Young
SY
Hwang
Tai Ju
TJ
Lee
Sam Yong
SY
Lee
Joon Kyoo
JK
Kook
Hoon
H
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007223:Infant; D016898:Interferon-alpha / Q000008:administration & dosage; D007376:Interleukin-2 / Q000008:administration & dosage; D008207:Lymphatic Metastasis / Q000473:pathology; D008543:Melanins / Q000096:biosynthesis; D008545:Melanoma / Q000151:congenital* / Q000473:pathology / Q000601:surgery; D012878:Skin Neoplasms / Q000151:congenital* / Q000601:surgery; D014747:Vinblastine / Q000008:administration & dosage
D016898:Interferon-alpha; D007376:Interleukin-2; D008543:Melanins; D014747:Vinblastine; D003606:Dacarbazine; D002945:Cisplatin