title: Successful triple combination therapy of disseminated absidia corymbifera infection in an adolescent with osteosarcoma.
abstract: Mucormycosis are opportunistic infections mostly observed in immunocompromised patients. We report the case of a 13-year-old girl who suffered a systemic mucormycosis without presenting the usual risk factors. She was undergoing antineoplastic chemotherapy for advanced osteosarcoma of the femur with an uncommunicative pathologic fracture and pulmonary metastasis. Absidia corymbifera was isolated from skin lesions at the primary tumor site. She subsequently developed fungal pulmonary localizations and blood vessel thrombosis. Surgical treatment together with systemic, high doses of liposomal amphotericin B, posaconazole, and caspofungin cured the local infection and controlled systemic lesions. Unfortunately, the break in chemotherapy led to pulmonary metastasis progression.
authors.affiliation: Pediatrics Oncology Department, Centre Hospitalier Universitaire Mère-Enfant, France.
authors.forename: Bénédicte Gaillard-Le
authors.initials: BG
authors.lastname: Roux
authors.forename: Françoise
authors.initials: F
authors.lastname: Méchinaud
authors.forename: Françoise
authors.initials: F
authors.lastname: Gay-Andrieu
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
authors.forename: Eric
authors.initials: E
authors.lastname: Dannaoui
authors.forename: Damien
authors.initials: D
authors.lastname: Hoinard
authors.forename: Nadege
authors.initials: N
authors.lastname: Corradini
mesh_terms: D020095:Absidia; D000293:Adolescent; D000666:Amphotericin B / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000077336:Caspofungin; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000008:administration & dosage; D005260:Female; D005266:Femoral Neoplasms / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D055666:Lipopeptides; D009091:Mucormycosis / Q000188:drug therapy*; D009894:Opportunistic Infections / Q000188:drug therapy*; D012516:Osteosarcoma / Q000150:complications* / Q000188:drug therapy; D014230:Triazoles / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D054714:Echinocandins; D055666:Lipopeptides; D014230:Triazoles; C068538:liposomal amphotericin B; C101425:posaconazole; D000666:Amphotericin B; D000077336:Caspofungin