Zinc-catalyzed reduction of amides: unprecedented selectivity and functional group tolerance.
A novel zinc-catalyzed reduction of tertiary amides was developed. This system shows remarkable chemoselectivity and substrate scope tolerating ester, ether, nitro, cyano, azo, and keto substituents.
Das
Shoubhik
S
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock, Germany.
Addis
Daniele
D
Zhou
Shaolin
S
Junge
Kathrin
K
Beller
Matthias
M
D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D010084:Oxidation-Reduction; D013379:Substrate Specificity; D015032:Zinc / Q000737:chemistry*
D000577:Amides; D015032:Zinc