title: Impact of marine drugs on animal reproductive processes.
abstract: The discovery and description of bioactive substances from natural sources has been a research topic for the last 50 years. In this respect, marine animals have been used to extract many new compounds exerting different actions. Reproduction is a complex process whose main steps are the production and maturation of gametes, their activation, the fertilisation and the beginning of development. In the literature it has been shown that many substances extracted from marine organisms may have profound influence on the reproductive behaviour, function and reproductive strategies and survival of species. However, despite the central importance of reproduction and thus the maintenance of species, there are still few studies on how reproductive mechanisms are impacted by marine bioactive drugs. At present, studies in either marine and terrestrial animals have been particularly important in identifying what specific fine reproductive mechanisms are affected by marine-derived substances. In this review we describe the main steps of the biology of reproduction and the impact of substances from marine environment and organisms on the reproductive processes.
authors.affiliation: Animal Physiology and Evolution Laboratory, Stazione Zoologica Anton Dohrn, Villa Comunale, Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Silvestre
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Tosti
mesh_terms: D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D005306:Fertilization; D005854:Germ Cells / Q000187:drug effects; D008297:Male; D008386:Marine Biology; D008387:Marine Toxins / Q000737:chemistry / Q000494:pharmacology; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects* / Q000502:physiology
chemical_list: D001688:Biological Products; D008387:Marine Toxins; D004364:Pharmaceutical Preparations