Phytotoxic activity of Salvia x jamensis.
A study has been carried out on the surface exudate of Salvia x jamensis, which showed a significant phytotoxic activity against Papaver rhoeas L. and Avena sativa L.. Bioguided separation of the exudate yielded active fractions from which 3 beta-hydroxy-isopimaric acid (1), hautriwaic acid (2), betulinic acid (3), 7,8 beta-dihydrosalviacoccin (4), isopimaric acid (5), 14 alpha-hydroxy-isopimaric acid (7), 15,16-epoxy-7 alpha, 10 beta-dihydroxy-clerod-3,13(16),14-trien-17,12;18,19-diolide (8), cirsiliol (5,3',4'-trihydroxy-6,7-dimethoxyflavone, 9) and two new neoclerodane diterpenes (6 and 10) were isolated. The structures of 6 and 10 were identified as 15,16-epoxy-10 beta-hydroxy-clerod-3,13(16),14-trien-17,12;18,19-diolide and 15,16-epoxy-7 alpha,10-dihydroxy-clerod-2,13(16),14-trien-17,12;18,19-diolide respectively on the basis of spectroscopic data analysis. All compounds, but 7, 8 and 10, were active in inhibiting the germination of the tested species.
Bisio
Angela
A
Dipartimento di Chimica e Tecnologie Farmaceutiche e Alimentari, University of Genoa, Genoa, Italy. bisio@dictfa.unige.it
Fraternale
Daniele
D
Damonte
Gianluca
G
Millo
Enrico
E
Lanteri
Anna Paola
AP
Russo
Eleonora
E
Romussi
Giovanni
G
Parodi
Brunella
B
Ricci
Donata
D
De Tommasi
Nunziatina
N
D018554:Avena / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D002734:Chlorophyll / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D018525:Germination / Q000187:drug effects; D006540:Herbicides / Q000737:chemistry* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D010207:Papaver / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D027544:Salvia / Q000633:toxicity*; D012639:Seeds / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D006540:Herbicides; D002734:Chlorophyll