title: Telomeric restriction analysis of vascular smooth muscle cells following balloon angioplasty in rabbits.
abstract: Intimal hyperplasia due to smooth muscle cell proliferation and migration has been reported to be responsible for the pathogenesis of atherosclerosis and restenosis, manifested following balloon angioplasty. In this study, we employed the balloon angioplasty model to study telomere length regulation in proliferating vascular smooth muscle cells. Our results showed that balloon angioplasty in iliac arteries resulted in intimal hyperplasia due to proliferation of the smooth muscle cells and small size telomeric restrictional fragments were evident in injured arteries.
authors.affiliation: Department of Pharmacology, Ege University, 35100 Izmir, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Ozsarlak-Sozer
authors.forename: Z
authors.initials: Z
authors.lastname: Kerry
authors.forename: I
authors.initials: I
authors.lastname: Oran
authors.forename: G
authors.initials: G
authors.lastname: Gokce
authors.forename: M
authors.initials: M
authors.lastname: Tosun
authors.forename: L
authors.initials: L
authors.lastname: Bechard
authors.forename: B
authors.initials: B
authors.lastname: Reel
authors.forename: M
authors.initials: M
authors.lastname: Yasa
authors.forename: B
authors.initials: B
authors.lastname: Lebe
authors.forename: Z
authors.initials: Z
authors.lastname: Topcu
mesh_terms: D000800:Angioplasty, Balloon; D000818:Animals; D049109:Cell Proliferation; D005260:Female; D006965:Hyperplasia / Q000209:etiology; D007083:Iliac Artery / Q000473:pathology; D008297:Male; D023421:Models, Animal; D009131:Muscle, Smooth, Vascular / Q000473:pathology*; D032389:Myocytes, Smooth Muscle / Q000473:pathology; D012150:Polymorphism, Restriction Fragment Length; D011817:Rabbits; D019098:Telomerase / Q000378:metabolism; D016615:Telomere / Q000378:metabolism*; D017539:Tunica Intima / Q000473:pathology
chemical_list: D019098:Telomerase