Extensive mammalian ancestry of pandemic (H1N1) 2009 virus.
We demonstrate that the novel pandemic influenza (H1N1) viruses have human virus-like receptor specificity and can no longer replicate in aquatic waterfowl, their historic natural reservoir. The biological properties of these viruses are consistent with those of their phylogenetic progenitors, indicating longstanding adaptation to mammals.
Ilyushina
Natalia A
NA
Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee 38105-3678, USA.
Kim
Jeong Ki
JK
Negovetich
Nicholas J
NJ
Choi
Young Ki
YK
Lang
Victoria
V
Bovin
Nicolai V
NV
Forrest
Heather L
HL
Song
Min Suk
MS
Pascua
Philippe Noriel Q
PN
Kim
Chul Joong
CJ
Webster
Robert G
RG
Webby
Richard J
RJ
D000818:Animals; D004196:Disease Outbreaks; D004197:Disease Reservoirs / Q000821:virology*; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics* / Q000502:physiology; D008322:Mammals / Q000821:virology*; D010802:Phylogeny; D011784:Quail / Q000821:virology; D013552:Swine; D013553:Swine Diseases / Q000821:virology*; D014779:Virus Replication / Q000235:genetics*
D019267:Hemagglutinin Glycoproteins, Influenza Virus