title: Rhodium carbenoid approach for introduction of 4-substituted (Z)-pent-2-enoates into sterically encumbered pyrroles and indoles.
abstract: An unusual rhodium carbenoid approach for introduction of 4-substituted (Z)-pent-2-enoates into sterically encumbered pyrroles and indoles is described. These studies show that (Z)-vinylcarbenoids have a greater tendency than (E)-vinylcarbenoids to react at the vinylogous position of the carbenoid rather than at the carbenoid center.
authors.affiliation: Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia, USA.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Lian
authors.forename: Huw M L
authors.initials: HM
authors.lastname: Davies
mesh_terms: D002087:Butyrates / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D009574:Nitro Compounds / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C508635:6-(nitrooxy)hexyl-(2z)-4-(acetyloxy)-3-(4-(methylsulfonyl)phenyl)-2-phenylbut-2-enoate; D002087:Butyrates; D007211:Indoles; D009574:Nitro Compounds; D009942:Organometallic Compounds; D011758:Pyrroles; D012238:Rhodium