Oseltamivir-resistant pandemic (H1N1) 2009 influenza in a severely ill patient: the first Australian case.
After a 10-day course of oral oseltamivir for pandemic (H1N1) 2009 influenza infection, a renal transplant recipient developed rapid-onset severe primary viral pneumonia due to oseltamivir-resistant virus. Respiratory failure progressed despite high-dose oral oseltamivir, nebulised zanamivir and cessation of immunosuppressive medications, but his condition improved with intravenous zanamivir. He subsequently died of non-respiratory complications. This is the first case of oseltamivir-resistant pandemic (H1N1) 2009 in Australia and the first report of resistance in a solid organ transplant recipient.
Speers
David J
DJ
Division of Microbiology and Infectious Diseases, PathWest Laboratory Medicine WA, Perth, WA. david.speers@health.wa.gov.au
Williams
Simon H
SH
Pinder
Mary
M
Moody
Harry R
HR
Hurt
Aeron C
AC
Smith
David W
DW
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D001315:Australia; D004196:Disease Outbreaks; D024882:Drug Resistance, Viral; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D016030:Kidney Transplantation; D008297:Male; D053139:Oseltamivir / Q000627:therapeutic use*
D000998:Antiviral Agents; D053139:Oseltamivir