Short peptides containing L-lysine and epsilon-aminocaproic acid as potential plasmin inhibitors.
Eight short peptides containing L-lysine and epsilon-aminocaproic acid were obtained and their effect on the amidolytic activities of plasmin, thrombin and trypsin was examined. Tripeptide amide Boc-EACA-L-Lys-EACA-NH2 was the most effective and specific plasmin inhibitor.
Purwin
M
M
Department of Organic Chemistry, Medical University, Bialystok, Poland.
Bruzgo
I
I
Markowska
A
A
Midura-Nowaczek
K
K
D015119:Aminocaproic Acid / Q000737:chemistry / Q000494:pharmacology*; D002021:Buffers; D005341:Fibrinolysin / Q000037:antagonists & inhibitors* / Q000737:chemistry; D005343:Fibrinolytic Agents / Q000737:chemistry / Q000494:pharmacology*; D008239:Lysine / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors; D014361:Trypsin Inhibitors / Q000737:chemistry / Q000494:pharmacology
D002021:Buffers; D005343:Fibrinolytic Agents; D010455:Peptides; D014361:Trypsin Inhibitors; D013917:Thrombin; D005341:Fibrinolysin; D008239:Lysine; D015119:Aminocaproic Acid