title: Synthesis, spectral characterization and bioassay of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxa-phosphinines].
abstract: Synthesis of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxaphos-phinines] (3a-j) were accomplished via two step process. It involves the prior preparation of monochloride intermediate (2) and its subsequent reaction with the amino acid esters in dry tetrahydrofuran-toluene in the presence of triethylamine at reflux temperature. These compounds were characterized by IR, 1H, 13C, 31P NMR and were found to exhibit potent in vitro antioxidant activity.
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh 517 502, India.
authors.forename: M
authors.initials: M
authors.lastname: Veera Narayana Reddy
authors.forename: A
authors.initials: A
authors.lastname: Bala krishna
authors.forename: C
authors.initials: C
authors.lastname: Suresh Reddy
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002374:Catalase / Q000037:antagonists & inhibitors*; D005978:Glutathione / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors*
chemical_list: D000975:Antioxidants; D001555:Benzene Derivatives; D009943:Organophosphorus Compounds; C519090:phosphinine; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione