title: Hyperpolarized 89Y complexes as pH sensitive NMR probes.
abstract: Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T(1) decay of magnetization. Due to its long T(1), the hyperpolarized (89)Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the (89)Y chemical shift dependence upon pH for two hyperpolarized (89)Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH.
authors.affiliation: Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
authors.forename: Ashish K
authors.initials: AK
authors.lastname: Jindal
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Merritt
authors.forename: Eul Hyun
authors.initials: EH
authors.lastname: Suh
authors.forename: Craig R
authors.initials: CR
authors.lastname: Malloy
authors.forename: A Dean
authors.initials: AD
authors.lastname: Sherry
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Kovács
mesh_terms: D006863:Hydrogen-Ion Concentration; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D015335:Molecular Probes / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D015019:Yttrium / Q000737:chemistry*
chemical_list: D008024:Ligands; D015335:Molecular Probes; D009942:Organometallic Compounds; D015019:Yttrium