Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease?
Mitochondria are dynamic organelles that undergo continuous fission and fusion, which could affect all aspects of mitochondrial function. Mitochondrial dysfunction has been well documented in Alzheimer's disease (AD). In the past few years, emerging evidence indicates that an imbalance of mitochondrial dynamics is involved in the pathogenesis of AD. In this review, we discuss in detail the abnormal mitochondrial dynamics in AD and how such abnormal dynamics may impact mitochondrial and neuronal function and contribute to the course of disease. Based on this discussion, we propose that mitochondrial dynamics could be a potential therapeutic target for AD.
Su
Bo
B
Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA.
Wang
Xinglong
X
Bonda
David
D
Perry
Gorge
G
Smith
Mark
M
Zhu
Xiongwei
X
D000544:Alzheimer Disease / Q000503:physiopathology* / Q000628:therapy*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D053327:Apolipoprotein E4 / Q000378:metabolism; D002986:Clinical Trials as Topic; D006801:Humans; D007211:Indoles / Q000494:pharmacology / Q000627:therapeutic use; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000166:cytology* / Q000378:metabolism* / Q000473:pathology; D053763:Presenilins / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism
D000975:Antioxidants; D053327:Apolipoprotein E4; D007211:Indoles; D053763:Presenilins; D016875:tau Proteins; C010119:latrepirdine