Acute effects of vinegar intake on some biochemical risk factors of atherosclerosis in hypercholesterolemic rabbits.
BACKGROUND
Exaggerated postprandial spikes in blood glucose and lipids induce proportional increases in oxidative stress, which acutely trigger impairment endothelial, inflammation and increased risk of future cardiovascular events. In this research, we have investigated acute effects of vinegar intake on some of the biochemical atherosclerosis risk factors in high cholesterol fed rabbits to see if we can find a probable protective value for it.


METHODS
The rabbits were randomly divided into four groups: normal diet, high cholesterol diet (%1 cholesterol), %1 cholesterol with 5 ml vinegar (low dose), %1 cholesterol with 10 ml vinegar (high dose). After fasting for 12-15 hours, blood samples were taken to determine baseline values. Three hours after feeding, blood samples were collected again to investigate acute effects of vinegar intake on the measured factors.


RESULTS
Using high-dose vinegar with cholesterolemic diet caused significant reduce in LDL-cholesterol (LDL-C), oxidized-LDL (ox-LDL), malondialdehyde (MDA), total cholesterol (TC) and apolipoprotein B (ApoB) in comparison with hypercholesterolemic diet. Consumption low-dose vinegar with cholesterolemic diet induced a significant decrease in fibrinogen and glucose compared to hypercholesterolemic diet. Level of serum nitrite, nitrate, triacylglycerol (TAG), HDL-cholesterol (HDL-C), apolipoprotein A (ApoA), serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetate transaminase (SGOT) and C-reactive protein (CRP) were not significantly difference in low and high doses vinegar with cholesterolemic diet compared to hypercholesterolemic diet. A significant difference was observed for LDL-C, ApoB100 and TC between low and high doses vinegar.


CONCLUSIONS
This study suggest that vinegar, might have some acute effects on biochemical risk factors of atherosclerosis and a probable protective value can be considered for its postprandial use.
Setorki
Mahbubeh
M
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. doctor.setorgi@gmail.com
Asgary
Sedighe
S
Eidi
Akram
A
Rohani
Ali Haeri
AH
Khazaei
Majid
M
D019342:Acetic Acid / Q000378:metabolism / Q000494:pharmacology*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001053:Apolipoproteins / Q000097:blood; D050197:Atherosclerosis / Q000517:prevention & control*; D001786:Blood Glucose / Q000378:metabolism; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000517:prevention & control; D008055:Lipids / Q000737:chemistry; D008297:Male; D062907:Oxaloacetic Acid / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D019518:Postprandial Period; D011817:Rabbits; D012307:Risk Factors; D000637:Transaminases / Q000097:blood
D001053:Apolipoproteins; D001786:Blood Glucose; D008055:Lipids; D010936:Plant Extracts; D062907:Oxaloacetic Acid; D000637:Transaminases; D000410:Alanine Transaminase; D019342:Acetic Acid