title: [Seroepidemical study of Coxsackievirus A 16, in four provinces, China, 2005].
abstract: OBJECTIVE
  To study the situation of 1- 5-years-old children's antibody against Coxsackievirus A group 16 strain (CVA16) in Guangdong, Heilongjiang,Yunnan Province and Xinjiang Uygur Autonomous Regions, China, 2005, it can offer scientific evidences for preventing and controlling CVA16 causative hand-food and mouth disease.
  
  
  METHODS
  Using microneutrilization test, to study 503 serum samples randomly selected from sera collected in 2005.
  
  
  RESULTS
  Positive rate of anti-CVA16 antibody were 41.90%, 9.40%, 40.00% and 34.40% in Guangdong, Heilongjiang,Yunnan and Xinjiang, respectively. Antibody titer was relative low (average, 1: 6.1) and there was no statistical difference of geometry mean of antibody titer (GMT) among Guangdong, Heilongjiang, Yunnan (F = 0.97, 0.40, 1.06, respectively; P > 0.05), while there had statistical difference of GMT between Heilongjiang and other three regions( F = 10.61, P < 0.00).
  
  
  CONCLUSIONS
  There had probably existed local epidemic in some regions of Guangdong, Heilongjiang, Yunnan Province and Xinjiang Uygur Autonomous Regions, China, 2005 or even before, but the area and degree of transmission and epidemic had difference. Children aged from 1- 5-years-old were relatively susceptible population of CVA16 infection.
authors.affiliation: Basic Medical School, Lanzhou University, Lanzhou 730000, China.
authors.forename: Zhao-hui
authors.initials: ZH
authors.lastname: Yang
authors.forename: Shuang-li
authors.initials: SL
authors.lastname: Zhu
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.forename: Hong-qiu
authors.initials: HQ
authors.lastname: An
authors.forename: Nai-ying
authors.initials: NY
authors.lastname: Mao
authors.forename: Yi-xin
authors.initials: YX
authors.lastname: Ji
authors.forename: Xue-bin
authors.initials: XB
authors.lastname: Guo
authors.forename: Shao-fu
authors.initials: SF
authors.lastname: Yin
authors.forename: Zong-jiu
authors.initials: ZJ
authors.lastname: Zhang
authors.forename: Wen-bo
authors.initials: WB
authors.lastname: Xu
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D002681:China / Q000453:epidemiology; D029821:Enterovirus A, Human / Q000276:immunology* / Q000302:isolation & purification; D004769:Enterovirus Infections / Q000453:epidemiology* / Q000276:immunology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral