[Do you know this syndrome?].
Brooke-Spiegler syndrome is an autosomal dominant inherited disease with predisposition to cutaneous adnexal neoplasms, most commonly cylindromas and trichoepitheliomas. Its onset is in the second or third decades of life. The histopathological exams of the lesions revealed a plethora of benign adnexal neoplasms, showing apocrine, follicular, and sebaceous differentiation. The treatment can be performed by excisional surgery, laser, cryotherapy, electrofulguration and dermabrasion. Due to the risk of malignancy, there is the need for clinical follow-up and genetic counseling.
Parente
José Napoleão Tavares
JN
Fundação de Dermatologia e Venereologia Alfredo da Matta, Manaus, AM, Brasil. napoleaoparente@oi.com.br
Schettini
Antonio Pedro Mendes
AP
Massone
Cesare
C
Parente
Ronald Tavares
RT
Schettini
Renata Almeida
RA
D000368:Aged; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology*; D013577:Syndrome