title: Evaluation of 3,4-dihydroquinazoline-2(1H)-thiones as inhibitors of alpha-MSH-induced melanin production in melanoma B16 cells.
abstract: Novel 3,4-dihydroquinazoline-2(1H)-thiones (QNTs) 1 were found to be potent inhibitors of alpha-MSH-induced melanin production. The effect of QNTs to inhibit melanin formation in B16 melanoma cells was screened in the presence of alpha-MSH. In defining the mechanism of activity, the effects on tyrosinase activity, on tyrosinase synthesis and on the depigmentation of melanin were evaluated. QNTs did not affect the catalytic activity of tyrosinase, but rather acted as an inhibitor of tyrosinase synthesis.
authors.affiliation: College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 305-764, Republic of Korea.
authors.forename: P
authors.initials: P
authors.lastname: Thanigaimalai
authors.forename: Ki-Cheul
authors.initials: KC
authors.lastname: Lee
authors.forename: Seong-Cheol
authors.initials: SC
authors.lastname: Bang
authors.forename: Jee-Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Cheong-Yong
authors.initials: CY
authors.lastname: Yun
authors.forename: Eunmiri
authors.initials: E
authors.lastname: Roh
authors.forename: Bang-Yeon
authors.initials: BY
authors.lastname: Hwang
authors.forename: Youngsoo
authors.initials: Y
authors.lastname: Kim
authors.forename: Sang-Hun
authors.initials: SH
authors.lastname: Jung
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008543:Melanins / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D011799:Quinazolines / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D000521:alpha-MSH / Q000037:antagonists & inhibitors* / Q000502:physiology
chemical_list: D008543:Melanins; D011799:Quinazolines; D000521:alpha-MSH