Calcineurin/NFAT signaling in lymphoid malignancies.
Deregulated calcium signaling is observed at different stages of tumorigenic processes. An important signaling pathway activated in response to calcium involves the protein phosphatase calcineurin and NFAT transcriptional factors. We review here recent data that indicate an important role of the calcineurin/NFAT pathway in lymphoma/leukemogenesis and discuss the potential therapeutic implications of these findings.
Gachet
Stephanie
S
CNRS UMR146 and Institut Curie, Centre Universitaire, 91405 Orsay, France.
Ghysdael
Jacques
J
D021581:Active Transport, Cell Nucleus; D000818:Animals; D019703:Calcineurin / Q000378:metabolism*; D020013:Calcium Signaling; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D006868:Hydrolysis; D007938:Leukemia / Q000378:metabolism*; D008024:Ligands; D008223:Lymphoma / Q000378:metabolism*; D008954:Models, Biological; D050778:NFATC Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction
D008024:Ligands; D050778:NFATC Transcription Factors; D019703:Calcineurin