title: Profiles of Chemical Effects on Cells (pCEC): a toxicogenomics database with a toxicoinformatics system for risk evaluation and toxicity prediction of environmental chemicals.
abstract: Profiles of Chemical Effects on Cells (pCEC) is a toxicogenomics database with a system of classifying chemicals that have effects on human health. This database stores and handles gene expression profiling information and categories of toxicity data. Chemicals are classified according to the specific tissues and cells they affect, the gene expression changes they induce, their toxicity and biological functions in this database system. The pCEC system also analyzes relationships between chemicals and the genes they affect in specific tissues and cells. The reason why we developed pCEC is to support decision-making within the context of environmental regulation. Especially, exposure to environmental chemicals during fetal and newborn development may result in a predisposition to various disorders such as cancer, learning disabilities and allergies later in life. The identification and prediction of hazardous chemicals using limited information are important issues in human health risk management. Therefore, various toxicity information including lethal dose 50 (LD50), toxicity pathways and pathological data were loaded into pCEC. pCEC is also a facility for query, analysis and prediction of unknown toxicochemical reaction pathways and biomarkers which are based on toxicoinformatical data mining approaches. This database is available online at http://project.nies.go.jp/eCA/cgi-bin/index.cgi. The current version of the database has information on the hepatotoxicity, reproductive toxicity and embryotoxicity of chemicals.
authors.affiliation: Research Center for Environmental Risk, National Institute for Environmental Studies, Ibaraki. hsone@nies.go.jp
authors.forename: Hideko
authors.initials: H
authors.lastname: Sone
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okura
authors.forename: Hiroko
authors.initials: H
authors.lastname: Zaha
authors.forename: Wataru
authors.initials: W
authors.lastname: Fujibuchi
authors.forename: Takeaki
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Akanuma
authors.forename: Reiko
authors.initials: R
authors.lastname: Nagano
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Ohsako
authors.forename: Junzo
authors.initials: J
authors.lastname: Yonemoto
mesh_terms: D000818:Animals; D019295:Computational Biology; D019992:Databases as Topic; D016208:Databases, Factual; D004785:Environmental Pollutants / Q000145:classification / Q000633:toxicity*; D020869:Gene Expression Profiling; D006801:Humans; D007928:Lethal Dose 50; D011237:Predictive Value of Tests; D040081:Protein Array Analysis; D018570:Risk Assessment / Q000379:methods*; D043922:Toxicogenetics
chemical_list: D004785:Environmental Pollutants