title: Comparative evaluation of dynamic contrast-enhanced perfusion with diffusion tensor imaging metrics in assessment of corticospinal tract infiltration in malignant glioma.
abstract: OBJECTIVE
  To compare dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) with diffusion tensor imaging (DTI) for predicting tumor infiltration in a conventional MRI normal-appearing internal capsule adjacent to the tumor in patients with glioblastoma multiforme.
  
  
  METHODS
  Thirty patients with glioblastoma multiforme underwent a neurological examination for motor assessment, DCE MRI, and DTI. On fused DCE and DTI images, regions of interest were placed on the normal-appearing internal capsule and the corresponding region of the contralateral internal capsule. These patients were pooled into group 1 (improved after surgery, n = 9) and group 2 (did not improve after surgery, n = 21) on the basis of motor strength. The DTI and perfusion metrics were statistically analyzed to look for a predictor of motor functionality.
  
  
  RESULTS
  Multivariate logistic regression analysis showed only cerebral blood volume to be the predictor of improvement in motor functionality after surgery (P = 0.043).
  
  
  CONCLUSIONS
  We conclude that cerebral blood volume appears to be the predictor of motor functionality after surgery and may indirectly suggest tumor infiltration, whereas DTI helps to precisely localize the fiber tracts.
authors.affiliation: Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
authors.forename: Rishi
authors.initials: R
authors.lastname: Awasthi
authors.forename: Sanjay Kumar
authors.initials: SK
authors.lastname: Verma
authors.forename: Mohammad
authors.initials: M
authors.lastname: Haris
authors.forename: Anup
authors.initials: A
authors.lastname: Singh
authors.forename: Sanjay
authors.initials: S
authors.lastname: Behari
authors.forename: Awadhesh Kumar
authors.initials: AK
authors.lastname: Jaiswal
authors.forename: Dinesh
authors.initials: D
authors.lastname: Rajput
authors.forename: Rakesh
authors.initials: R
authors.lastname: Pandey
authors.forename: Ram K S
authors.initials: RK
authors.lastname: Rathore
authors.forename: Chandra M
authors.initials: CM
authors.lastname: Pandey
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Gupta
mesh_terms: D000328:Adult; D001810:Blood Volume; D001921:Brain / Q000098:blood supply / Q000473:pathology; D001931:Brain Mapping / Q000379:methods; D001932:Brain Neoplasms / Q000473:pathology*; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D011237:Predictive Value of Tests; D011712:Pyramidal Tracts / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media