title: Decreased innervation of eczematous skin in NC/Nga atopic mice during chronic mild stress.
abstract: OBJECTIVE
  A connection between chronic mild stress and altered innervation in the skin of an atopic mouse strain, NC/Nga, was studied.
  
  
  METHODS
  We used three groups of mice, stressed control (SC, stressed but not immunized with a mite antigen), non-stressed eczematous (NSE, not stressed but immunized) and stressed eczematous (SE, stressed and immunized).
  
  
  RESULTS
  There was a decrease of protein gene product (PGP) 9.5 positive nerve fibers in SE compared to SC mice, in both epidermis and dermis, also in SE compared to NSE mice. Also a decrease in growth associated protein (GAP)-43 positive nerve fibers was seen in SE compared to SC, in both epidermis and dermis.
  
  
  CONCLUSIONS
  Chronic mild stress in atopic mice leads to decreased innervation in eczematous lesions.
authors.affiliation: Karolinska Institutet, Department of Medicine Solna, Dermatology and Venereology Unit, Karolinska University Hospital, Stockholm Sweden. louise.lonndahl@ki.se
authors.forename: Louise
authors.initials: L
authors.lastname: Lönndahl
authors.forename: Sol-Britt
authors.initials: SB
authors.lastname: Lonne-Rahm
authors.forename: Klas
authors.initials: K
authors.lastname: Nordlind
authors.forename: Elvar
authors.initials: E
authors.lastname: Theodorsson
authors.forename: Husameldin
authors.initials: H
authors.lastname: El-Nour
mesh_terms: D000818:Animals; D002908:Chronic Disease; D003345:Corticosterone / Q000097:blood; D004485:Eczema / Q000503:physiopathology*; D005260:Female; D019922:GAP-43 Protein / Q000032:analysis; D051379:Mice; D009416:Nerve Regeneration; D012867:Skin / Q000294:innervation*; D013315:Stress, Psychological / Q000503:physiopathology*; D043222:Ubiquitin Thiolesterase / Q000032:analysis
chemical_list: D019922:GAP-43 Protein; D043222:Ubiquitin Thiolesterase; C496976:Uchl1 protein, mouse; D003345:Corticosterone