Plumisclerin A, a diterpene with a new skeleton from the soft coral Plumigorgia terminosclera.
A novel compound, named plumisclerin A (1), was isolated from samples of the soft coral Plumigorgia terminosclera collected at Mayotte Island. The compound possesses the novel plumisclerane carbon skeleton, including a tricyclo[4,3,1,0(1,5)]decane ring. Its structure and relative stereochemistry were elucidated by extensive spectroscopic analysis, including HREIMS, COSY, HSQC, HMBC, TOCSY, and NOESY experiments. In addition, the novel compound displayed in vitro cytotoxicity against selected cancer cell lines.
Martín
María Jesús
MJ
Medicinal Chemistry Department, PharmaMar S.A., Pol. Ind. La Mina Norte, Avda. de los Reyes 1, 28770 Colmenar Viejo (Madrid), Spain.
Fernández
Rogelio
R
Francesch
Andrés
A
Amade
Philippe
P
de Matos-Pita
Susana S
SS
Reyes
Fernando
F
Cuevas
Carmen
C
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy
D004224:Diterpenes; C549483:plumisclerin A