The promise of natural products for blocking early events in skin carcinogenesis.
This perspective on Stratton et al. (beginning on p. 160), Kowalczyk et al. (beginning on p. 170), and Katiyar et al. (beginning on p. 179) highlights the common theme of translational investigation of natural substances and their molecular effects and mechanisms in preventing skin squamous cell carcinoma, which has potentially severe clinical consequences. These studies comprise results of naturally occurring phytochemicals and green tea polyphenols in mouse models of UV-induced and chemically induced skin carcinogenesis and results of perillyl alcohol in a phase IIa clinical trial-all pointing to the great promise of this exciting approach for better understanding of and preventing skin cancer.
Clifford
John L
JL
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center-Shreveport and Feist-Weiller Cancer Center, 71130, USA. jcliff@lsuhsc.edu
DiGiovanni
John
J
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000517:prevention & control*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D017322:Clinical Trials, Phase II as Topic; D005419:Flavonoids / Q000494:pharmacology; D006801:Humans; D051379:Mice; D039821:Monoterpenes / Q000494:pharmacology; D010636:Phenols / Q000494:pharmacology; D008517:Phytotherapy / Q000379:methods*; D059808:Polyphenols; D012878:Skin Neoplasms / Q000517:prevention & control*
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D039821:Monoterpenes; D010636:Phenols; D059808:Polyphenols; C032208:perillyl alcohol