Comparison of the duration of antimicrobial activity of 2 different antimicrobial central venous catheters.
We compared the duration of antimicrobial effectiveness of 2 different antimicrobial catheters. The baseline activity of minocycline-rifampin catheters was greater than that of silver-platinum-carbon catheters against Staphylococcus aureus, Staphylococcus epidermidis, and Enterococcus faecalis. The antimicrobial activity of the minocycline-rifampin catheters against these pathogens persisted for up to 12 days, while that of the silver-platinum-carbon catheters was depleted by day 10 (P < .05).
Matheos
Theofilos
T
Department of Anesthesiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Walz
J Matthias
JM
Adams
Janice P
JP
Johnson
Karen
K
Longtine
Karen
K
Longtine
Jaclyn
J
O'Neill
Melissa
M
Heard
Stephen O
SO
D000890:Anti-Infective Agents / Q000494:pharmacology; D001422:Bacterial Adhesion / Q000187:drug effects; D002405:Catheterization, Central Venous / Q000009:adverse effects / Q000295:instrumentation*; D002408:Catheters, Indwelling / Q000382:microbiology*; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D008404:Massachusetts; D008911:Minocycline / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology
D000890:Anti-Infective Agents; D008911:Minocycline; D012293:Rifampin