[Study of BOLD signal in activated areas during mental calculation based on functional MRI].
The study of brain function by fMRI is currently a cynosure of researchers. In this study, we performed mental calculation as a cognitive task and used MRI for data collection. Activated brain areas were found by the software of SPM. Moreover, the average of BOLD signal (Average-BOLD) and the principal component signal by principal component analysis (PCA) of BOLD signal (PCA-BOLD) in the regions of interest (ROD) were figured. We compared these two sorts of signals versus the signal designed by the experiment. The results show that PCA-BOLD signal is a better parameter for quantitive evaluations of the activated brain areas and for the basic research of brain function by scaling the intensity of ROI.
Yu
Haiyan
H
Department of Biomedical Engineering, College of Automation, Nanjing University of Aeronautics & Astronautics, Nanjing 210016, China.
Qian
Zhiyu
Z
Lu
Guangming
G
Zhang
Zhiqiang
Z
D001921:Brain / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D003071:Cognition; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology; D025341:Principal Component Analysis; D012815:Signal Processing, Computer-Assisted
D010100:Oxygen