[Current progress in researches on the gene delivery systems based on nanoparticles technology].
Gene therapy, as a therapeutic treatment for genetic or acquired diseases, is attracting much interest in the research community, leading to noteworthy developments over the past two decades. Although this field is still dominated by viral vectors, novel nonviral gene delivery systems based on nanoparticle technology have recently received an ever increasing attention in order to overcome the safety problems of viral vectors as well as the cytotoxicity of conventional nonviral vectors. This review presented the aspects of bionanotechnology involved in the gene delivery process and explored the recent developments and achievements of inorganic nanodelivery systems for gene transfection.
Qi
Xiaojin
X
Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Xu
Haiyan
H
D018390:Gene Targeting / Q000379:methods / Q000639:trends*; D018014:Gene Transfer Techniques / Q000639:trends*; D015316:Genetic Therapy / Q000639:trends; D005822:Genetic Vectors; D006801:Humans; D053758:Nanoparticles / Q000627:therapeutic use*; D036103:Nanotechnology / Q000379:methods; D014162:Transfection / Q000379:methods*