Association of single nucleotide polymorphisms in adiponectin and its receptor genes with polycystic ovary syndrome.
OBJECTIVE
To examine the possible association of adiponectin (ADIPOQ), adiponectin receptor (ADIPOR1/2) gene polymorphisms with polycystic ovary syndrome (PCOS) and their influence on insulin resistance in Japanese women with PCOS.


METHODS
Six single nucleotide polymorphisms (SNPs) in ADIPOQ and ADIPOR1/2 were genotyped in 59 infertile Japanese women with PCOS and 97 healthy Japanese controls. In addition, the association between the genotype and allele frequencies of these SNPs and the clinical phenotypes was analyzed in PCOS patients.


RESULTS
There was no significant difference in the genotype and allele frequencies of the 6 SNPs between PCOS patients and controls. In the PCOS group, women with the GG genotype of 45T > G of ADIPOQ had a significantly higher score in the homeostasis model assessment for insulin resistance, fasting blood sugar and insulin level than those with other genotypes. Furthermore, a statistically significant difference in the genotype frequency of 45T > G polymorphism was observed between PCOS subjects with insulin resistance (n = 38) and controls (p = 0.011).


CONCLUSIONS
The 6 SNPs of ADIPOQ and ADIPOR1/2 were not associated with a risk of PCOS. However, the 45T > G SNP in the ADIPOQ may be related to insulin resistance in Japanese women with PCOS.
Yoshihara
Kosuke
K
Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata University, Chuo Ward, Niigata, Japan.
Yahata
Tetsuro
T
Kashima
Katsunori
K
Mikami
Takeaki
T
Tanaka
Kenichi
K
D052242:Adiponectin / Q000235:genetics*; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001786:Blood Glucose / Q000235:genetics / Q000378:metabolism; D015992:Body Mass Index; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics*; D007564:Japan; D008055:Lipids / Q000097:blood; D018579:Patient Selection; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D054419:Receptors, Adiponectin / Q000235:genetics*
D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D054419:Receptors, Adiponectin