title: Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries.
abstract: In the present work we investigated the mechanism involved in the vasodilator effect induced by euxanthone in rat small mesenteric arteries. We observed that euxanthone induced concentration-dependent vasodilatation in arteries by a mechanism independent on the release of endothelial factors, such as nitric oxide (NO) and cyclooxygenase-derived factors. In addition our results also suggest that euxanthone induced its vasodilator effect through inhibition of calcium-sensitive mechanisms activated by protein kinase C, rather than by inhibition of contractions dependent on the release of the intracellular calcium stores or by inhibition of voltage-operated calcium channels.
authors.affiliation: Departamento de Farmacologia, Instituto de Ciências Biológicas - Universidade Federal de Minas Gerais. Belo Horizonte - MG, Brazil.
authors.forename: D V
authors.initials: DV
authors.lastname: Câmara
authors.forename: V S
authors.initials: VS
authors.lastname: Lemos
authors.forename: M H
authors.initials: MH
authors.lastname: Santos
authors.forename: T J
authors.initials: TJ
authors.lastname: Nagem
authors.forename: S F
authors.initials: SF
authors.lastname: Cortes
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D028084:Clusiaceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014665:Vasodilator Agents / Q000494:pharmacology*; D044004:Xanthones / Q000494:pharmacology*
chemical_list: D015220:Calcium Channels; D010936:Plant Extracts; D014665:Vasodilator Agents; D044004:Xanthones; C404221:euxanthone; D011493:Protein Kinase C; D002118:Calcium