Theoretical versus empirical allometry: Facts behind theories and application to pharmacokinetics.
Although, no credible data are available, it is widely believed that the pharmacokinetic parameters such as clearance, volume of distribution, and elimination half-life can be scaled with a fixed exponent of 0.75, 1.0, and 0.25, respectively. However, logically it is difficult to perceive that the exponents of allometry for a given parameter will revolve around a fixed number. Over the last 80 years, theoretical biologists and physiologists are entangled in an argument whether the exponent of basal metabolic rate against body weight is 0.67 or 0.75. There are evidence for and against these two exponents. However, in-depth investigative works suggest that there is not really any universal exponent for any allometrically related parameter and the exponent of allometry depends on several factors. The main focus of this report is to show the readers that there is enough evidence from experimental data that negate the notion of fixed exponents in biology, physiology, and pharmacokinetics. In short, the notion of a fixed exponent is theoretical and there is no evidence that the exponent of a physiological or pharmacokinetic parameter revolves around a fixed number.
Mahmood
Iftekhar
I
Division of Hematology, Office of Blood Review & Research(OBRR), Center for Biologic Evaluation and Research, Food & Drug Administration, Rockville, Maryland, USA. iftekhar.mahmood@fda.hhs.gov
D002648:Child; D006801:Humans; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics
D004364:Pharmaceutical Preparations