Synthesis and biological evaluation of water-soluble organogermanium.
Interferon (INF) is an effective drug in treating several human diseases. Ge-132, which is the most common and well-studied organic germanium, has been reported to induce INF-gamma and has undergone clinical trials with promising preclinical results. However, it has been reported that long-term ingestion or high doses of organic Ge-132 causes similar toxic effects as GeO(2) because Ge-132 can be easily contaminated with significant amounts of inorganic germanium during the preparation. In this study, we synthesized the water-soluble organogermanium compound (Ge-OH) without possible contamination with toxic inorganic germanium and showed that Ge-OH is a better INF-gamma inducer than Ge-132 by an animal study.
Choi
Sumi
S
Department of Chemistry, College of Natural Science, Chung-Ang University, Seoul 156-756, Republic of Korea.
Oh
Changwon
C
Han
Jeongsoo
J
Park
Jina
J
Choi
Jee-Hye
JH
Min
Na Young
NY
Lee
Kwang-Ho
KH
Park
Ae Ja
AJ
Kim
Yeo Jin
YJ
Jang
Su Jeong
SJ
Lee
Duck-Hyung
DH
Ham
Seung Wook
SW
D000818:Animals; D004353:Drug Evaluation, Preclinical; D005857:Germanium / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000494:pharmacology*; D012995:Solubility; D014867:Water / Q000737:chemistry*
D009930:Organic Chemicals; D005857:Germanium; D014867:Water