Obesity and abdominal wound healing in rats.
BACKGROUND
Treatment for obesity essentially has to do with weight loss, which can be achieved through surgical procedures. Despite the considerable rise in the number of such procedures, the relationship between obesity and the healing process has not been totally clarified.


OBJECTIVE
To investigate abdominal wound healing in obese Wistar rats on the seventh and fourteenth days following a laparotomy.


METHODS
Thirty-six Wistar rats were randomly distributed into two groups, the control and experiment group. The control group were fed on either a standard diet for the species and the experiment group were put on a high calorie diet. After 116 days, all the animals were submitted to a laparotomy followed by laparorrhaphy. After euthanasia on the seventh or fourteenth day, fragments of the abdominal wound containing the scar were submitted to histopathological and tensiometric analysis.


RESULTS
The average weight of the animals from the experiment group was higher than that of the control group (p<0.001). The difference in the resistance of the cutaneous scars was not significant. The aponeurotic scars were more resistant in the control group after seven days (p=0.011) and fourteen days (p=0.040). There was no difference in terms of intensity of the inflammatory reaction and the collagen density was similar in both groups.


CONCLUSIONS
In rats, obesity lowered the resistance of the aponeurotic scars but not the skin scars. It did not interfere with the delayed inflammatory response and the collagen density.
Biondo-Simões
Maria de Lourdes Pessole
Mde L
Scientific Methodology, PUCPR, Brazil. biondo@avalon.sul.com.br
Zammar
Guilherme Roberto
GR
Fernandes
Rodrigo dos Santos
Rdos S
Biondo-Simões
Rachel
R
Mello
Flavia Stica Ritzdorf de
FS
Noronha
Lucia de
Ld
D034861:Abdominal Wall / Q000601:surgery*; D000818:Animals; D002921:Cicatrix / Q000473:pathology; D003094:Collagen / Q000378:metabolism; D004195:Disease Models, Animal; D002149:Energy Intake; D008297:Male; D009765:Obesity / Q000601:surgery*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000502:physiology*
D003094:Collagen