title: [Study of BOLD signal in activated areas during mental calculation based on functional MRI].
abstract: The study of brain function by fMRI is currently a cynosure of researchers. In this study, we performed mental calculation as a cognitive task and used MRI for data collection. Activated brain areas were found by the software of SPM. Moreover, the average of BOLD signal (Average-BOLD) and the principal component signal by principal component analysis (PCA) of BOLD signal (PCA-BOLD) in the regions of interest (ROD) were figured. We compared these two sorts of signals versus the signal designed by the experiment. The results show that PCA-BOLD signal is a better parameter for quantitive evaluations of the activated brain areas and for the basic research of brain function by scaling the intensity of ROI.
authors.affiliation: Department of Biomedical Engineering, College of Automation, Nanjing University of Aeronautics & Astronautics, Nanjing 210016, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Yu
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Qian
authors.forename: Guangming
authors.initials: G
authors.lastname: Lu
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D001921:Brain / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D003071:Cognition; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology; D025341:Principal Component Analysis; D012815:Signal Processing, Computer-Assisted
chemical_list: D010100:Oxygen