Age-related decline in the microstructural integrity of white matter in children with early- and continuously-treated PKU: a DTI study of the corpus callosum.
Structural, volumetric, and microstructural abnormalities have been reported in the white matter of the brain in individuals with phenylketonuria (PKU). Very little research, however, has been conducted to investigate the development of white matter in children with PKU, and the developmental trajectory of their white matter microstructure is unknown. In the current study, diffusion tensor imaging (DTI) was used to examine the development of the microstructural integrity of white matter across six regions of the corpus callosum in 34 children (7-18 years of age) with early- and continuously-treated PKU. Comparison was made with 61 demographically-matched healthy control children. Two DTI variables were examined: mean diffusivity (MD) and relative anisotropy (RA). RA was comparable to that of controls across all six regions of the corpus callosum. In contrast, MD was restricted for children with PKU in anterior (i.e., genu, rostral body, anterior midbody) but not posterior (posterior midbody, isthmus, splenium) regions of the corpus callosum. In addition, MD restriction became more pronounced with increasing age in children with PKU in the two most anterior regions of the corpus callosum (i.e., genu, rostral body). These findings point to an age-related decrement in the microstructural integrity of the anterior white matter of the corpus callosum in children with PKU.
White
Desiree A
DA
Department of Psychology, Campus Box 1125, Washington University, One Brookings Drive, St. Louis, MO 63130, USA. dawhite@wustl.edu
Connor
Lisa Tabor
LT
Nardos
Binyam
B
Shimony
Joshua S
JS
Archer
Rebecca
R
Snyder
Abraham Z
AZ
Moinuddin
Asif
A
Grange
Dorothy K
DK
Steiner
Robert D
RD
McKinstry
Robert C
RC
D000293:Adolescent; D000375:Aging / Q000473:pathology*; D016022:Case-Control Studies; D002648:Child; D003337:Corpus Callosum / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D010661:Phenylketonurias / Q000473:pathology*