Involvement of phosphodiesterases in autoimmune diseases.
We have previously shown that several phosphodiesterase (PDE) subtypes are up-regulated in muscles and lymph node cells (LNC) of rats with experimental autoimmune myasthenia gravis (EAMG). In the present study we investigated PDE expression during the course of EAMG and experimental allergic encephalomyelitis (EAE) and found that the up-regulated expression of selected PDE subtypes in both experimental models is correlated with disease severity. In EAMG, PDE expression is correlated also with muscle damage. A similar up-regulation of PDE was also observed in the respective human diseases, MG and multiple sclerosis (MS). Our findings suggest that change in PDE expression levels is a general phenomenon in autoimmune diseases and may also be used as a marker for disease severity.
Mizrachi
Keren
K
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Aricha
Revital
R
Feferman
Tali
T
Kela-Madar
Neta
N
Mandel
Ilana
I
Paperna
Tamar
T
Miller
Ariel
A
Ben-Nun
Avraham
A
Berrih-Aknin
Sonia
S
Souroujon
Miriam C
MC
Fuchs
Sara
S
D000293:Adolescent; D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002648:Child; D004195:Disease Models, Animal; D018450:Disease Progression; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000201:enzymology* / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D009103:Multiple Sclerosis / Q000201:enzymology* / Q000276:immunology / Q000503:physiopathology; D009133:Muscular Atrophy / Q000201:enzymology / Q000276:immunology / Q000503:physiopathology; D009157:Myasthenia Gravis / Q000201:enzymology* / Q000276:immunology / Q000503:physiopathology; D020720:Myasthenia Gravis, Autoimmune, Experimental / Q000201:enzymology* / Q000276:immunology / Q000503:physiopathology; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D011237:Predictive Value of Tests; D051381:Rats; D011917:Rats, Inbred Lew; D012720:Severity of Illness Index; D015854:Up-Regulation / Q000276:immunology; D055815:Young Adult
D015415:Biomarkers; D007527:Isoenzymes; D010727:Phosphoric Diester Hydrolases