[Blood groups and discoid lupus erythematosus].
BACKGROUND
Discoid lesion is the commonest cutaneous finding in lupus erythematosus and chronic types have their own immunological features, with Th1 inflammation profile. Although many diseases have association with blood-group systems, this fact was not enlightened in discoid lupus erythematosus.


OBJECTIVE
To investigate the association between blood groups (ABO and Rh) and discoid lupus erythematosus.


METHODS
A prospective cross-sectional study assessing clinical information, blood group systems (ABO and Rh), FAN and C4 serum levels from discoid lupus patients without characteristics of systemic disease, was carried out at a clinic from a Brazilian university hospital.


RESULTS
Sixty-nine patients were enrolled in the study, 71.0% were females (p1:160 in 31.9%, and low levels of C4 in 8.7%. There was no significant difference between the frequency of blood groups from discoid lupus patients and local population, however, blood group A was associated to disseminate forms of the disease (OR 4.1 and p < 0.05).


CONCLUSIONS
Discoid lupus erythematosus patients with ABO and Rh blood groups exhibit similar frequencies as in the general population; nevertheless, disseminate clinical forms were more prevalent among group A patients.
Tamega
Andréia de Almeida
Ade A
serviço de dermatologia, Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, SP, Brasil.
Bezerra
Lílian Valéria Guerra da Silva Pinto
LV
Pereira
Fabíola de Paula
Fde P
Miot
Hélio Amante
HA
D000017:ABO Blood-Group System; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D012204:Rh-Hr Blood-Group System
D000017:ABO Blood-Group System; D012204:Rh-Hr Blood-Group System