title: Natural zoonotic infections of two marmosets and one domestic rabbit with herpes simplex virus type 1 did not reveal a correlation with a certain gG-, gI- or gE genotype.
abstract: Infections with herpes simplex virus type 1 (HSV-1) are not restricted to humans but infrequently may be transmitted to certain animal species, in some cases resulting in severe disease, including encephalitis and death. Recent studies demonstrate that humanderived HSV-1 field isolates can be typed according to their gG- gIand gE gene sequences. We investigated whether HSV-1 infections of animals were predominantly caused by a certain genotype. Isolates derived from two marmosets and one domestic rabbit, however, revealed different genotypes. Despite the very limited number of investigated animal-derived HSV-1 strains, this result does not point towards the existence of certain HSV-1 genotypes with a higher potential of being transmitted to animals.
authors.affiliation: University of Veterinary Medicine, Vienna, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Sekulin
authors.forename: J
authors.initials: J
authors.lastname: Janková
authors.forename: J
authors.initials: J
authors.lastname: Kolodziejek
authors.forename: H P
authors.initials: HP
authors.lastname: Huemer
authors.forename: A
authors.initials: A
authors.lastname: Gruber
authors.forename: J
authors.initials: J
authors.lastname: Meyer
authors.forename: N
authors.initials: N
authors.lastname: Nowotny
mesh_terms: D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000821:virology; D002144:Callithrix / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D020803:Encephalitis, Herpes Simplex / Q000175:diagnosis / Q000662:veterinary* / Q000821:virology; D005838:Genotype; D018259:Herpesvirus 1, Human / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D008992:Monkey Diseases / Q000821:virology*; D011817:Rabbits / Q000821:virology*; D017422:Sequence Analysis, DNA; D014759:Viral Envelope Proteins / Q000235:genetics; D015047:Zoonoses
chemical_list: D004279:DNA, Viral; D014759:Viral Envelope Proteins; C044768:glycoprotein E, herpes simplex virus type 1; C064959:glycoprotein I, herpes simplex virus type 1; C050591:glycoprotein gG-1, herpes simplex virus type 1