title: Effect of subchronic phencyclidine administration on sucrose preference and hippocampal parvalbumin immunoreactivity in the rat.
abstract: Persistent blockade of NMDA receptor function by repeated phencyclidine dosing produces pathophysiological changes that model deficits observed in schizophrenia. The present study investigates the effects of subchronic phencyclidine administration (PCP; 2 or 5mg/kg bi-daily for 7 days followed by a drug-free period) on sucrose choice, a measure of anhedonia. Sucrose preference in a two-bottle sucrose-water choice test was assessed 1 and 2 weeks after PCP. Results showed no differences in sucrose intake between PCP rats and controls, nor a difference in water intake or total volume of liquid consumed at either time-point. Six weeks post-PCP, analysis of brains showed a reduction in expression of parvalbumin immunoreactive neurons in the hippocampus with significant reductions localised to the CA1 and CA2/3 regions. These results demonstrate that while subchronic PCP may not be a valid model for the negative symptom of anhedonia observed in schizophrenia, it induces pathology in the brain in hippocampal subregions that are reminiscent of changes observed in schizophrenia.
authors.affiliation: Health Innovations Research Institute and School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia. trisha.jenkins@rmit.edu.au <trisha.jenkins@rmit.edu.au>
authors.forename: Trisha A
authors.initials: TA
authors.lastname: Jenkins
authors.forename: Michael K
authors.initials: MK
authors.lastname: Harte
authors.forename: Gavin P
authors.initials: GP
authors.lastname: Reynolds
mesh_terms: D000342:Affective Symptoms / Q000523:psychology; D000818:Animals; D002755:Choice Behavior; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010320:Parvalbumins / Q000378:metabolism*; D010622:Phencyclidine / Q000008:administration & dosage*; D057181:Pleasure; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D012559:Schizophrenia / Q000378:metabolism* / Q000473:pathology*; D012565:Schizophrenic Psychology; D013395:Sucrose; D013649:Taste
chemical_list: D010320:Parvalbumins; D016194:Receptors, N-Methyl-D-Aspartate; D013395:Sucrose; D010622:Phencyclidine