Variations in body mass index of users of depot-medroxyprogesterone acetate as a contraceptive.
BACKGROUND
Weight gain is a frequent reason for discontinuing the contraceptive with depot-medroxyprogesterone acetate (DMPA).


METHODS
This 3-year retrospective cohort study assessed body mass index (BMI; kg/m(2)) variations in 379 current or past DMPA users compared to TCu380A intrauterine device (IUD) users matched for age and BMI, categorized into G1 (normal weight), G2 (overweight) or G3 (obese) according to baseline BMI. Variations in weight and BMI were evaluated using analysis of variance.


RESULTS
BMI increased progressively in all groups but significantly more in G1 and G2 DMPA users compared to nonusers and according to duration of use. In the G3 subgroup, weight trends were similar in the DMPA and IUD users.


CONCLUSIONS
Normal and overweight women increased BMI with DMPA use; however, obese women did not increase weight. Weight increase in DMPA users could be associated with metabolic alterations related to duration of use in normal and overweight women and to alterations already present in obese women. Prospective studies are required to determine triggering factors. DMPA use <or=3 years was not associated with weight increase in women with BMI (kg/m(2)) >or=30.
Pantoja
Márcia
M
Human Reproduction Unit, Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas (UNICAMP), and National Institute of Hormones and Women Health, Campinas, SP 13084-971, Brazil.
Medeiros
Tatiane
T
Baccarin
Maria Carolina
MC
Morais
Sirlei Siani
SS
Bahamondes
Luis
L
Fernandes
Arlete Maria dos Santos
AM
D000328:Adult; D000704:Analysis of Variance; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects*; D015331:Cohort Studies; D003271:Contraceptive Agents, Female; D005260:Female; D006801:Humans; D007435:Intrauterine Devices, Copper / Q000009:adverse effects; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage* / Q000009:adverse effects*; D009765:Obesity; D050177:Overweight; D012189:Retrospective Studies; D015430:Weight Gain / Q000187:drug effects*
D003271:Contraceptive Agents, Female; D017258:Medroxyprogesterone Acetate