title: The protective effect of radicicol against renal ischemia--reperfusion injury in mice.
abstract: Overexpression of heat shock protein 70 kDa (HSP70) is known to confer cellular protection against ischemia-reperfusion (I/R) injury. Radicicol, a HSP90 inhibitor, has been reported to induce the expression of HSP70 protein. Here we studied whether radicicol attenuated renal I/R injury in vivo. Treatment of mice with radicicol ameliorated renal I/R injury and increased renal HSP70 mRNA and protein. Administration of radicicol with quercetin, an inhibitor of HSP70 induction, eliminated the renoprotective effect of radicicol. Our results suggest that the up-regulation of renal HSP70 protein by radicicol leads to a novel drug therapy against renal I/R injury.
authors.affiliation: Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Sonoda
authors.forename: Worapat
authors.initials: W
authors.lastname: Prachasilchai
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kondo
authors.forename: Naoko
authors.initials: N
authors.lastname: Yokota-Ikeda
authors.forename: Sayaka
authors.initials: S
authors.lastname: Oshikawa
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Ito
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D018840:HSP70 Heat-Shock Proteins / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D018942:Macrolides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011794:Quercetin / Q000494:pharmacology; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D015427:Reperfusion Injury / Q000517:prevention & control*; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; D018942:Macrolides; D012333:RNA, Messenger; D011794:Quercetin; C035359:monorden