title: New approaches to visual rehabilitation for cortical blindness: outcomes and putative mechanisms.
abstract: Cortical blindness is a chronic loss of vision following damage to the primary visual cortex (V1) or its postchiasmal afferents. Such damage is followed by a brief period of spontaneous plasticity that rarely lasts beyond 6 months. Following this initial phase, the visual deficit is thought to be stable, intractable, and permanent. Cortically blind subjects demonstrate spontaneous oculomotor adaptations to their deficits that can be further improved by saccadic localization training. However, saccadic training does not improve visual sensitivity in the blind field. In contrast, recent studies by a number of independent groups suggest that localized, repetitive perceptual training can improve visual sensitivity in the blind field, although mechanisms underlying the observed recovery remain unclear. This review discusses the current literature on rehabilitative strategies used for cortical blindness with emphasis on the use of perceptual training methods. The putative mechanisms that underlie the resulting, training-induced visual improvements are then outlined, along with the special challenges posed to their elucidation by the great variability in the extent and sometimes nature of the V1 damage sustained in different individuals.
authors.affiliation: University of Rochester Flaum Eye Institute, Rochester, New York 14642, USA.
authors.forename: Anasuya
authors.initials: A
authors.lastname: Das
authors.forename: Krystel R
authors.initials: KR
authors.lastname: Huxlin
mesh_terms: D019575:Blindness, Cortical / Q000209:etiology / Q000503:physiopathology / Q000534:rehabilitation*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology; D016896:Treatment Outcome; D014793:Visual Cortex / Q000293:injuries* / Q000503:physiopathology; D014795:Visual Pathways / Q000503:physiopathology; D014796:Visual Perception / Q000502:physiology*