title: Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma.
abstract: The synthesis and in vitro activity of R(+)-Limonene derivatives against Leishmania and Trypanosoma cruzi strains are reported. Seven compounds have shown better in vitro activity against Leishmania (V.)braziliensis than the standard drug pentamidine. Additionally, we have identified two promising new anti-T. cruzi limonene derivatives.
authors.affiliation: Lab. de Síntese Orgânica Medicinal (LaSOM), Faculdade de Farmácia, UFRGS, Avenida Ipiranga, 2752, sala 705, 90610-000 Porto Alegre, RS, Brazil.
authors.forename: Cedric S
authors.initials: CS
authors.lastname: Graebin
authors.forename: Maria de F
authors.initials: Mde F
authors.lastname: Madeira
authors.forename: Jenicer K U
authors.initials: JK
authors.lastname: Yokoyama-Yasunaka
authors.forename: Danilo C
authors.initials: DC
authors.lastname: Miguel
authors.forename: Silvia R B
authors.initials: SR
authors.lastname: Uliana
authors.forename: Diego
authors.initials: D
authors.lastname: Benitez
authors.forename: Hugo
authors.initials: H
authors.lastname: Cerecetto
authors.forename: Mercedes
authors.initials: M
authors.lastname: González
authors.forename: Ricardo Gomes da
authors.initials: RG
authors.lastname: Rosa
authors.forename: Vera Lucia
authors.initials: VL
authors.lastname: Eifler-Lima
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D053138:Cyclohexenes / Q000494:pharmacology*; D066298:In Vitro Techniques; D007891:Leishmania / Q000187:drug effects*; D000077222:Limonene; D008253:Macaca mulatta; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013729:Terpenes / Q000494:pharmacology*; D014345:Trypanosoma / Q000187:drug effects*
chemical_list: D000981:Antiprotozoal Agents; D053138:Cyclohexenes; D013729:Terpenes; D000077222:Limonene