Advanced cancer with situs inversus totalis associated with KIF3 complex deficiency: report of two cases.
Situs inversus totalis (SIT) is a relatively rare congenital anomaly, occurring at an incidence of 1 in 10 000-50 000 live births. Although there are some case reports of SIT with the presence of cancer, there are few reports on the relationship between SIT and cancer. However, the recent phylogenetic investigations of this condition suggest that this may be linked to the development and progression of cancer on the molecular level. The key elements are one of the intracellular motor proteins, the KIF3 complex, and the cell-adhesion factors N-cadherin and beta-catenin. We herein present the cases of advanced gastric cancer and lung cancer with SIT, and review the relationship between SIT and the development and progression of cancer.
Haruki
Tomohiro
T
Department of Surgery, Tottori Prefectural Central Hospital, 730 Ezu, Tottori, Japan.
Maeta
Yoshihiko
Y
Nakamura
Sei-ichi
S
Sawata
Takashi
T
Shimizu
Tetsu
T
Kishi
Kiyoshi
K
Miyasaka
Shigeto
S
Maeta
Hiroyuki
H
Morimoto
Keisuke
K
Taniguchi
Iwao
I
D000230:Adenocarcinoma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016547:Kinesins / Q000172:deficiency*; D008175:Lung Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008297:Male; D012857:Situs Inversus / Q000150:complications* / Q000378:metabolism; D013274:Stomach Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D016896:Treatment Outcome; D051176:beta Catenin / Q000378:metabolism
C495270:CTNNB1 protein, human; D015820:Cadherins; D051176:beta Catenin; D016547:Kinesins