title: Lonomia obliqua venom: In vivo effects and molecular aspects associated with the hemorrhagic syndrome.
abstract: Caterpillar envenomation has been an emergent health issue. Lonomia obliqua is a medically important animal that causes a hemorrhagic syndrome that can progress to acute renal failure, intracranial hemorrhage and death. In the past few years the molecular characterization of L. obliqua venom in addition to experimental models has provided fundamental information to the understanding of the envenomation syndrome. Herein studies from several authors which characterized the complex toxic-pharmacological actions of whole venom are reviewed.
authors.affiliation: Laboratório de Bioquímica Farmacológica, Centro de Biotecnologia (UFRGS), Av. Bento Gonçalves, 9500, CEP 91501-970, Porto Alegre, RS, Brazil.
authors.forename: Antônio F M
authors.initials: AF
authors.lastname: Pinto
authors.forename: Markus
authors.initials: M
authors.lastname: Berger
authors.forename: José
authors.initials: J
authors.lastname: Reck
authors.forename: Renata M S
authors.initials: RM
authors.lastname: Terra
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Guimarães
mesh_terms: D000818:Animals; D000997:Antivenins / Q000627:therapeutic use; D001180:Arthropod Venoms / Q000737:chemistry / Q000633:toxicity*; D001777:Blood Coagulation / Q000187:drug effects; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006474:Hemorrhagic Disorders / Q000097:blood / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007299:Insect Bites and Stings / Q000188:drug therapy / Q000473:pathology; D007668:Kidney / Q000187:drug effects; D007814:Larva / Q000737:chemistry / Q000235:genetics; D008954:Models, Biological; D009036:Moths / Q000737:chemistry* / Q000235:genetics / Q000254:growth & development; D010974:Platelet Aggregation / Q000187:drug effects; D013577:Syndrome
chemical_list: D000997:Antivenins; D001180:Arthropod Venoms