title: Challenges of major obstetric haemorrhage.
abstract: Every minute of every day, a woman dies in pregnancy or childbirth. The biggest killer is obstetric haemorrhage, the successful treatment of which is a challenge for both the developed and developing worlds. The presence of an attendant at every birth and access to emergency obstetric care are key to reducing maternal morbidity and mortality in the developing world while resource-rich countries have a rising caesarean section rate with its consequential effect on the incidence of abnormal placentation and its link with peripartum hysterectomy. Management of obstetric haemorrhage involves early recognition, assessment and resuscitation. Various methods are available to try to stop the bleeding - from pharmacological methods to aid uterine contraction (e.g., oxytocinon, ergometrine and prostaglandins) to surgical methods to stem the bleeding (e.g., balloon tamponade, compression sutures or arterial ligation). Interventional radiology can be used if placenta accreta is suspected. Cell salvage has been introduced into obstetrics relatively recently in an attempt to reduce allogeneic transfusion.
authors.affiliation: Simpson Centre for Reproductive Health, Royal Infirmary, Edinburgh, UK. arlene.wise@luht.scot.nhs.uk <arlene.wise@luht.scot.nhs.uk>
authors.forename: Arlene
authors.initials: A
authors.lastname: Wise
authors.forename: Vicki
authors.initials: V
authors.lastname: Clark
mesh_terms: D005260:Female; D006801:Humans; D013513:Obstetric Surgical Procedures / Q000379:methods; D006473:Postpartum Hemorrhage / Q000188:drug therapy / Q000628:therapy*; D011247:Pregnancy; D015642:Radiology, Interventional; D016879:Salvage Therapy