title: A low-dose ipsilateral lung restriction improves 3-d conformal planning for partial breast radiation therapy.
abstract: In trials of 3D conformal external beam partial breast radiotherapy (PBRT), the dosimetrist must balance the priorities of achieving high conformity to the target versus minimizing low-dose exposure to the normal structures. This study highlights the caveat that in the absence of a low-dose lung restriction, the use of relatively en-face fields may meet trial-defined requirements but expose the ipsilateral lung to unnecessary low-dose radiation. Adding a low-dose restriction that ≤ 20% of the ipsilateral lung should receive 10% of the prescribed dose resulted in successful plans in 88% of cases. This low-dose lung limit should be used in PBRT planning.
authors.affiliation: Radiation Therapy Program, British Columbia Cancer Agency, Vancouver Island Centre, University of British Columbia, University of Victoria, Victoria, British Columbia, Canada.
authors.forename: Tracy
authors.initials: T
authors.lastname: Mitchell
authors.forename: Pauline T
authors.initials: PT
authors.lastname: Truong
authors.forename: Lee
authors.initials: L
authors.lastname: Salter
authors.forename: Cathy
authors.initials: C
authors.lastname: Graham
authors.forename: Helene
authors.initials: H
authors.lastname: Gaffney
authors.forename: Wayne
authors.initials: W
authors.lastname: Beckham
authors.forename: Ivo A
authors.initials: IA
authors.lastname: Olivotto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001943:Breast Neoplasms / Q000532:radiotherapy*; D003198:Computer Simulation; D005260:Female; D006801:Humans; D008168:Lung / Q000528:radiation effects*; D008875:Middle Aged; D008954:Models, Biological; D009928:Organ Specificity; D011835:Radiation Protection / Q000379:methods*; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*