Chemical composition and antimycobacterial activity of the essential oil from Anemia tomentosa var. anthriscifolia.
The essential oil from Anemia tomentosa var. anthriscifolia showed in vitro activity against Mycobacterium tuberculosis (MIC 100 microg/ml) and therefore was characterized by gas chromatography (GC) and by gas chromatography coupled with mass spectrometry (GC-MS). The major constituents of this essential oil were triquinane sesquiterpenes: silphiperfol-6-ene (14.7%), (-)-epi-presilphiperfolan-1-ol (30.6%), presilphiperfol-7-ene (3.9%), cameroonan-7 alpha-ol (4.4%), prenopsan-8-ol (1.9%) and presilphiperfolan-8-ol (8.3%), suggesting the existence of different chemotypes for this species. The essential oil was fractionated by column chromatography and its major constituent and fractions were assayed against Mycobacterium tuberculosis and M. smegmatis. (-)-epi-Presilphiperfolan-1-ol exhibited an MIC of 120 microg/ml against M. tuberculosis H37Rv.
Pinto
Shaft Corrêa
SC
Universidade Federal do Rio de Janeiro, Núcleo de Pesquisas de Produtos Naturais, CCS, Bloco H, Ilha do Fundão, 21941-590, Rio de Janeiro, Brazil.
Leitão
Gilda Guimarães
GG
de Oliveira
Danilo Ribeiro
DR
Bizzo
Humberto Ribeiro
HR
Ramos
Daniela Fernandes
DF
Coelho
Tatiane Silveira
TS
Silva
Pedro Eduardo A
PE
Lourenço
Maria Cristina S
MC
Leitão
Suzana Guimarães
SG
D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology*; D001938:Brazil; D008401:Gas Chromatography-Mass Spectrometry; D008055:Lipids / Q000737:chemistry; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*
D000995:Antitubercular Agents; D008055:Lipids; D009822:Oils, Volatile