Effects and applications of ultrashort-lived prehydrated electrons in radiation biology and radiotherapy of cancer.
The subpicosecond-lived prehydrated electron (e(pre)(-)) is a fascinating species in radiation biology and radiotherapy of cancer. Using femtosecond time-resolved laser spectroscopy, we have recently resolved that e(pre)(-) states are electronically excited states and have lifetimes of approximately 180 fs and approximately 550 fs, after the identification and removal of a coherence spike, respectively. Notably, the weakly bound e(pre)(-) (< 0 eV) has the highest yield among all the radicals generated in the cell during ionizing radiation. Recently, it has been demonstrated that dissociative electron transfer (DET) reactions of e(pre)(-) can lead to important biological effects. By direct observation of the transition states of the DET reactions, we have showed that DET reactions of e(pre)(-) play key roles in bond breakage of nucleotides and in activations of halopyrimidines as potential hypoxic radiosensitizers and of the chemotherapeutic drug cisplatin in combination with radiotherapy. This review discusses all of these findings, which may lead to improved strategies in radiotherapy of cancer, radioprotection of humans and in discovery of new anticancer drugs.
Lu
Qing-Bin
QB
Departments of Physics, Biology and Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L3G1, Canada. qblu@uwaterloo.ca
D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004249:DNA Damage; D004583:Electrons; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D011839:Radiation, Ionizing; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage; D011853:Radiobiology; D014867:Water
D011838:Radiation-Sensitizing Agents; D014867:Water; D002945:Cisplatin