Roles of the prostaglandin E2 receptors EP subtypes in Alzheimer's disease.
Neuroinflammation has always been of concern in the pathogenesis of Alzheimer's disease (AD). As a major inflammatory mediator, prostaglandin E(2) (PGE(2)) plays an important role in the inflammatory process of AD. Up to now, there is still controversy on the neuroprotective or neurotoxic role of PGE(2). However, the role of PGE(2) in neurodegeneration may be far more complex, due to the 4 EP receptor subtypes. This article aims to summarize the relationship between PGE(2) receptor EP subtypes and AD. It is believed that a better understanding of the PGE(2) receptor EP subtypes may help to clarify the relation between inflammation and AD, and to develop novel therapeutic strategies targeting specific EP receptor for AD treatment.
Wei
Li-Li
LL
Department of Mental Health, Sir Run Run Shaw Hospital, Zhejiang University Medical School, Hangzhou 310016,China.
Shen
Yue-Di
YD
Zhang
Ying-Chun
YC
Hu
Xing-Yue
XY
Lu
Pei-Ling
PL
Wang
Li
L
Chen
Wei
W
D000544:Alzheimer Disease / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D015232:Dinoprostone / Q000378:metabolism; D006801:Humans; D018078:Receptors, Prostaglandin E / Q000378:metabolism*; D015398:Signal Transduction
D018078:Receptors, Prostaglandin E; D015232:Dinoprostone