Magnetic resonance venography and genetics of a female patient with pelvic venous thrombosis.
A femoral vein thrombosis, originally diagnosed with conventional ultrasound, was fully elucidated and monitored utilizing serial high-resolution magnetic resonance venography in a 19-year-old female with a family history of venous thromboembolism. Genetic testing revealed she was heterozygous for a F5 gene mutation, an abnormality that predisposes carriers to factor V Leiden thrombophilia. An additional risk factor included use of oral contraceptive pills. Subsequent testing of her family uncovered other carriers of the mutation, allowing for the implementation of preventive measures for the entire family. Although magnetic resonance venography has not yet proven to be a cost-effective method for monitoring clot resolution, the case presented here encourages further research on the clinical utility and cost-benefit of utilizing this technology for monitoring venous thrombosis and for clinical management purposes.
Perkins
Thomas G
TG
Philips Healthcare, 595 Miner Road, Cleveland, OH 44143, USA.
Mishra
Rahul K
RK
Siddiqui
Yasmin
Y
Hanson
Eric H
EH
Rowley
Robb K
RK
Ramos
Erica R
ER
Orrison
William W
WW
D000925:Anticoagulants / Q000627:therapeutic use; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects; D004252:DNA Mutational Analysis; D005165:Factor V / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006579:Heterozygote; D006801:Humans; D018810:Magnetic Resonance Angiography; D009154:Mutation; D010375:Pedigree; D010388:Pelvis / Q000098:blood supply*; D010690:Phlebography / Q000379:methods*; D011237:Predictive Value of Tests; D012307:Risk Factors; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D055815:Young Adult
D000925:Anticoagulants; D003278:Contraceptives, Oral, Hormonal; D005165:Factor V