title: Malabsorption may contribute to malnutrition in the elderly.
abstract: Malnutrition, either actually malnourished or at risk, is present in 80% of the elderly population presenting to hospital for admission. Although many factors contribute to this situation, one yet to be explored is malabsorption. We therefore aimed to assess nutritional status as well as the prevalence of altered mucosal permeability and celiac disease among a group of elderly patients presenting for rehabilitation. Forty-eight subjects were recruited (16 females) with a mean age of 83.7 (SD 6.1), body mass index 21.8 kg/m(2) (SD 3.9), mini-nutritional assessment (MNA) 19.5 (SD 3.4). They had no current gastrointestinal symptoms and undertook an assessment of mucosal permeability using the dual sugar absorption test of lactulose (7.5 g) and rhamnose (1 g). Ten of the 48 subjects had increased mucosal permeability with an L:R ration ranging from 0.0860 to 7.706 (N 0.01-0.08). These subjects were all at risk or malnourished according to the MNA score and they had a significantly lower mean MNA score of 17.2 (SD 3.5) compared to normal absorbers with a mean of 19.5 (SD 3.4). Two of the subjects had positive tissue trans-glutaminase antibodies. The higher risk of potential malabsorption in this elderly population has significant implications both for nutritional supplementation and for drug absorption as well as being a possible major contributor to malnutrition.
authors.forename: Terry
authors.initials: T
authors.lastname: Bolin
authors.forename: Marian
authors.initials: M
authors.lastname: Bare
authors.forename: Gideon
authors.initials: G
authors.lastname: Caplan
authors.forename: Suzie
authors.initials: S
authors.lastname: Daniells
authors.forename: Margaret
authors.initials: M
authors.lastname: Holyday
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000097:blood; D002446:Celiac Disease / Q000150:complications / Q000276:immunology; D005260:Female; D015577:Geriatric Assessment; D005972:Glutaminase / Q000276:immunology; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology*; D008286:Malabsorption Syndromes / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D044342:Malnutrition / Q000097:blood / Q000209:etiology* / Q000276:immunology; D015596:Nutrition Assessment; D009752:Nutritional Status; D010539:Permeability; D012307:Risk Factors
chemical_list: D000906:Antibodies; D005972:Glutaminase