title: Poly(A)-binding protein (PABP): a common viral target.
abstract: Cytoplasmic PABP [poly(A)-binding protein] is a multifunctional protein with well-studied roles in mRNA translation and stability. In the present review, we examine recent evidence that the activity of PABP is altered during infection with a wide range of viruses, bringing about changes in its stability, complex formation and intracellular localization. Targeting of PABP by both RNA and DNA viruses highlights the role of PABP as a central regulator of gene expression.
authors.affiliation: MRC Human Reproductive Sciences Unit, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK. richard.smith@hrsu.mrc.ac.uk
authors.forename: Richard W P
authors.initials: RW
authors.lastname: Smith
authors.forename: Nicola K
authors.initials: NK
authors.lastname: Gray
mesh_terms: D004267:DNA Viruses / Q000235:genetics / Q000378:metabolism; D015967:Gene Expression Regulation, Viral / Q000235:genetics / Q000502:physiology; D008954:Models, Biological; D039102:Poly(A)-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D012328:RNA Viruses / Q000235:genetics / Q000378:metabolism
chemical_list: D039102:Poly(A)-Binding Proteins