title: [Do you know this syndrome?].
abstract: Brooke-Spiegler syndrome is an autosomal dominant inherited disease with predisposition to cutaneous adnexal neoplasms, most commonly cylindromas and trichoepitheliomas. Its onset is in the second or third decades of life. The histopathological exams of the lesions revealed a plethora of benign adnexal neoplasms, showing apocrine, follicular, and sebaceous differentiation. The treatment can be performed by excisional surgery, laser, cryotherapy, electrofulguration and dermabrasion. Due to the risk of malignancy, there is the need for clinical follow-up and genetic counseling.
authors.affiliation: Fundação de Dermatologia e Venereologia Alfredo da Matta, Manaus, AM, Brasil. napoleaoparente@oi.com.br
authors.forename: José Napoleão Tavares
authors.initials: JN
authors.lastname: Parente
authors.forename: Antonio Pedro Mendes
authors.initials: AP
authors.lastname: Schettini
authors.forename: Cesare
authors.initials: C
authors.lastname: Massone
authors.forename: Ronald Tavares
authors.initials: RT
authors.lastname: Parente
authors.forename: Renata Almeida
authors.initials: RA
authors.lastname: Schettini
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology*; D013577:Syndrome