title: Deep-brain stimulation of the nucleus accumbens in obsessive compulsive disorder: clinical, surgical and electrophysiological considerations in two consecutive patients.
abstract: Obsessive compulsive disorder is a highly disabling pathological condition which in the most severe and drug-resistant form can severely impair social, cognitive and interpersonal functioning. Deep-brain stimulation has been demonstrated to be an effective and safe interventional procedure in such refractory forms in selected cases. We here report the first Italian experience in the treatment of this pathology by means of nucleus accumbens stimulation, pointing out to some technical data which could be of help in localization of the target.
authors.affiliation: Fondazione Istituto Nazionale Neurologico "Carlo Besta", Via Caloria 11, 20133, Milan, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Franzini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Messina
authors.forename: Orsola
authors.initials: O
authors.lastname: Gambini
authors.forename: Riccardo
authors.initials: R
authors.lastname: Muffatti
authors.forename: Silvio
authors.initials: S
authors.lastname: Scarone
authors.forename: Roberto
authors.initials: R
authors.lastname: Cordella
authors.forename: Giovanni
authors.initials: G
authors.lastname: Broggi
mesh_terms: D000328:Adult; D046690:Deep Brain Stimulation / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy; D008279:Magnetic Resonance Imaging; D008297:Male; D008839:Microelectrodes; D019635:Neurosurgical Procedures / Q000379:methods; D009714:Nucleus Accumbens / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy*; D057234:Preoperative Period; D011569:Psychiatric Status Rating Scales; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome