title: Antimicrobial natural products: an update on future antibiotic drug candidates.
abstract: Over the last decade, it has become clear that antimicrobial drugs are losing their effectiveness due to the evolution of pathogen resistance. There is therefore a continuing need to search for new antibiotics, especially as new drugs only rarely reach the market. Natural products are both fundamental sources of new chemical diversity and integral components of today's pharmaceutical compendium, and the aim of this review is to explore and highlight the diverse natural products that have potential to lead to more effective and less toxic antimicrobial drugs. Although more than 300 natural metabolites with antimicrobial activity have been reported in the period 2000-2008, this review will describe only those with potentially useful antimicrobial activity, viz. with MICs in the range 0.02-10 microg mL(-1). A total of 145 compounds from 13 structural classes are discussed, and over 100 references are cited.
authors.affiliation: Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, 63000 Bahawalpur, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Saleem
authors.forename: Mamona
authors.initials: M
authors.lastname: Nazir
authors.forename: Muhammad Shaiq
authors.initials: MS
authors.lastname: Ali
authors.forename: Hidayat
authors.initials: H
authors.lastname: Hussain
authors.forename: Yong Sup
authors.initials: YS
authors.lastname: Lee
authors.forename: Naheed
authors.initials: N
authors.lastname: Riaz
authors.forename: Abdul
authors.initials: A
authors.lastname: Jabbar
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology; D004345:Drug Industry; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D008031:Lignin / Q000737:chemistry / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology; D013256:Steroids / Q000737:chemistry / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology; D044004:Xanthones / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D001688:Biological Products; D003374:Coumarins; D005419:Flavonoids; D018942:Macrolides; D010455:Peptides; D012503:Saponins; D013256:Steroids; D013729:Terpenes; D044004:Xanthones; D008031:Lignin