Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: benzene, CAS: 71-43-2.
The role of genotoxic events in the aetiology of benzene induced tumours cannot be ruled out. Dose response modelling of the data for benzene gave a BMDL10 for female Zymbal gland carcinoma of 17.6 mg/kg-bw/d following adjustment to daily average doses. The MOEs ranged from 2 x 10(6) to 0.4 x 10(6) depending on the assumptions used in the exposure estimation.
Smith
Benjamin
B
Firmenich S.A., Switzerland. publications@ilsieurope.be
Cadby
Peter
P
DiNovi
Michael
M
Setzer
R Woodrow
RW
D000818:Animals; D001554:Benzene / Q000633:toxicity*; D001555:Benzene Derivatives / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D003627:Data Interpretation, Statistical; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D008297:Male; D051379:Mice; D015233:Models, Statistical; D009153:Mutagens / Q000633:toxicity*; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology; D051381:Rats
D001555:Benzene Derivatives; D002273:Carcinogens; D009153:Mutagens; D001554:Benzene