title: Vena porta thrombosis in patient with inherited factor VII deficiency.
abstract: Most clotting factor VII (FVII)-deficient patients suffer from bleeding episodes and occasionally thromboembolic complications after surgical interventions or replacement therapy. However, thromboses without apparent triggering factors may occur as well. We report a case of a pregnant woman with inherited FVII deficiency and chronic vena porta thrombosis. She presented at 32 weeks of gestation with spontaneously increased international normalized ratio, severe thrombocytopenia and very few unspecific symptoms. The extensive examination of the patient revealed cavernous transformation of the portal vein with well expressed portosystemic collaterals, heterozygosity for three common polymorphisms in FVII gene, associated with reduction in plasma FVII levels, and no other factors predisposing to thrombosis.
authors.affiliation: Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark. JOLKLO01@heh.regionh.dk
authors.forename: Jolanta
authors.initials: J
authors.lastname: Klovaite
authors.forename: Lennart
authors.initials: L
authors.lastname: Friis-Hansen
authors.forename: Fin S
authors.initials: FS
authors.lastname: Larsen
authors.forename: Nielsaage
authors.initials: N
authors.lastname: Toffner-Clausen
authors.forename: Ole W
authors.initials: OW
authors.lastname: Bjerrum
mesh_terms: D000328:Adult; D002585:Cesarean Section; D005168:Factor VII Deficiency / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D011169:Portal Vein / Q000473:pathology*; D011247:Pregnancy; D013927:Thrombosis / Q000150:complications* / Q000175:diagnosis