Direct synthesis of phosphinopeptides containing C-terminal alpha-aminoalkylphosphinic acids.
A series of phosphinopeptides containing C-terminal alpha-aminoalkylphosphinic acids were prepared in good yields directly in one-pot reactions of 2-(N-benzoxycarbonylamino)alkanamides/peptide amides, aldehydes, and aryldichlorophosphines, followed by hydrolysis. In the current method, the peptide bond was formed in a Mannich-type reaction.
Meng
Fanhua
F
State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, 100029, Beijing, People's Republic of China.
Xu
Jiaxi
J
D000447:Aldehydes / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000138:chemical synthesis*; D010721:Phosphinic Acids / Q000737:chemistry*
D000447:Aldehydes; D010455:Peptides; D010721:Phosphinic Acids