title: Computational vascular fluid-structure interaction: methodology and application to cerebral aneurysms.
abstract: A computational vascular fluid-structure interaction framework for the simulation of patient-specific cerebral aneurysm configurations is presented. A new approach for the computation of the blood vessel tissue prestress is also described. Simulations of four patient-specific models are carried out, and quantities of hemodynamic interest such as wall shear stress and wall tension are studied to examine the relevance of fluid-structure interaction modeling when compared to the rigid arterial wall assumption. We demonstrate that flexible wall modeling plays an important role in accurate prediction of patient-specific hemodynamics. Discussion of the clinical relevance of our methods and results is provided.
authors.affiliation: Department of Structural Engineering, University of California, San Diego, La Jolla, 92093, USA. yuri@ucsd.edu
authors.forename: Y
authors.initials: Y
authors.lastname: Bazilevs
authors.forename: M-C
authors.initials: MC
authors.lastname: Hsu
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.forename: T
authors.initials: T
authors.lastname: Kvamsdal
authors.forename: S
authors.initials: S
authors.lastname: Hentschel
authors.forename: J G
authors.initials: JG
authors.lastname: Isaksen
mesh_terms: D001783:Blood Flow Velocity; D001808:Blood Vessels / Q000503:physiopathology*; D003198:Computer Simulation; D019937:Diagnostic Techniques and Procedures; D020342:Finite Element Analysis; D018056:Hemorheology / Q000502:physiology*; D006801:Humans; D002532:Intracranial Aneurysm / Q000503:physiopathology*; D008954:Models, Biological; D033081:Shear Strength; D013314:Stress, Mechanical