Small molecule probes that target Abl kinase.
Two different strategies, namely a dialdehyde-based cross-linking and photo-affinity labeling, have been developed to generate small molecule activity-based probes (ABPs) for the Abelson (Abl) tyrosine kinase, of which probe 13, derived from the photo-affinity approach, showed specific labeling of Abl kinase present in a crude mammalian proteome.
Kalesh
Karunakaran A
KA
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Sim
Derek S B
DS
Wang
Jigang
J
Liu
Kai
K
Lin
Qingsong
Q
Yao
Shao Q
SQ
D000447:Aldehydes / Q000737:chemistry; D000595:Amino Acid Sequence; D020134:Catalytic Domain; D005456:Fluorescent Dyes / Q000737:chemistry; D016315:Proto-Oncogene Proteins c-abl / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D000447:Aldehydes; D005456:Fluorescent Dyes; D011725:Pyridines; D011994:Recombinant Proteins; D016315:Proto-Oncogene Proteins c-abl