Re: "Mutagenic action of isocyanates used in the production of polyurethanes" by M. Anderson, M-L Binderup, P. Kiel, H. Larson, J. Maxild. Scand J Work Environ Health 6 (1980) 221-226.
The Ames test results published in Andersen et al's article can, at most, serve as encouragement to engage in more-detailed studies, for example, long-term animal experiments with MDI or epidemiologic studies on man. (Such studies are already in progress or are in the planning stage.) At the moment, it is absolutely unjustifiable to suggest that isocyanates--provided that the customary TLV values are observed--represent a serious health hazard to man in the form of cancer or genetic damage.
Diller
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WF
D003485:Cyanates / Q000633:toxicity*; D006801:Humans; D009152:Mutagenicity Tests; D011140:Polyurethanes
D003485:Cyanates; D011140:Polyurethanes