Familial crossed polysyndactyly in four generations of an Indian family.
BACKGROUND
Polydactyly is the most common malformation of the limbs. "Crossed" polydactyly of hands and feet, i.e., preaxial in one and postaxial in the other, is extremely rare. It has not been included in the standard classification of hand and feet anomalies.


METHODS
We report an Indian family with 7 affected members across 4 generations who had "crossed polysyndactyly". All but one affected member had involvement of all four limbs. There were no other congenital anomalies in any of the family members.


RESULTS
Familial crossed polysyndactyly appeared to follow an autosomal dominant transmission. This is probably the first case of familial crossed polysyndactyly without any associated anomalies.


CONCLUSIONS
Familial crossed polysyndactyly is a rare malformation and all family members should be screened for other congenital malformations.
Dewan
Pooja
P
Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, 110096, Delhi, India. poojadewan@hotmail.com
Agarwal
Nitin
N
Dewan
Preeti
P
Batta
Vineet
V
D000328:Adult; D005260:Female; D005385:Fingers / Q000002:abnormalities*; D006801:Humans; D007194:India; D007231:Infant, Newborn; D008297:Male; D010375:Pedigree; D013576:Syndactyly / Q000235:genetics*; D014034:Toes / Q000002:abnormalities*