title: Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice.
abstract: OBJECTIVE
  To compare the chemopreventive efficacy of Polyphenon E (Poly E), (-)-epigallocatechin-3-gallate (EGCG) and Polyphenon E without EGCG (Poly E-EGCG) on the development of benzo(a)pyrene (B(a)P)-induced lung tumors in A/J mice.
  
  
  METHODS
  Female A/J mice were given a single intraperitoneal injection of B(a)P (100 mg/kg body weight). One week after B(a)P injection, animals received AIN-76A purified powder diet containing 0.975% (wt/wt) EGCG, 0.525% (wt/wt) Poly E-EGCG or 1.5% (wt/wt) Poly E for 24 weeks or control diet with no additives.
  
  
  RESULTS
  Poly E treatment significantly decreased tumor multiplicity by 52% and tumor load by 64%, while EGCG and Poly E-EGCG did not significantly inhibit lung tumor multiplicity. EGCG was more stable in a complex mixture (Poly E) than as a pure compound.
  
  
  CONCLUSIONS
  EGCG was ineffective when administered by diet likely due to its instability. Thus, EGCG's efficacy on mice lung tumorigenesis requires the presence of other tea catechins.
authors.affiliation: Department of Surgery and Alvin J Siteman Cancer Center, Washington University in St. Louis, 660 South Euclid Avenue, Campus Box 8109, St Louis, Missouri 63110, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Huijing
authors.initials: H
authors.lastname: Fu
authors.forename: Jing
authors.initials: J
authors.lastname: Pan
authors.forename: Jun
authors.initials: J
authors.lastname: He
authors.forename: Seto
authors.initials: S
authors.lastname: Ryota
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Hara
authors.forename: Yian
authors.initials: Y
authors.lastname: Wang
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Lubet
authors.forename: Ming
authors.initials: M
authors.lastname: You
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018890:Chemoprevention; D005260:Female; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008175:Lung Neoplasms / Q000178:diet therapy / Q000473:pathology / Q000517:prevention & control*; D051379:Mice
chemical_list: D016588:Anticarcinogenic Agents; D002392:Catechin; C045651:epigallocatechin gallate; C472086:polyphenon E