[Evaluation of antioxidant and hepatoprotective properties of strain Lactobacillus casei 114001 in carbon tetrachloride-induced liver toxicity model].
Daily oral administration to rats of probiotic strain Lactobacillus casei 114001 (L.c.) at dose 2,8 x 10(10) cfu/rat during 8 days reduced oxidative stress and liver lesions, induced by a single intraperitoneal administration of carbon tetrachloride (CCl4) at dose 0.5 ml/kg b.w. It was evidenced by several histopathological and biochemical markers, characteristic for CCl4 toroxicity. Membrane damage by toxin was reduced in rats, treated with L.c.: alanine aminotransferase activity in plasma and nonsedimentable activity of lysosomal enzymes in liver were significantly decreased. Treatment with L.c. resulted in partial recovery of activities of antioxidant enzymes and enzymes of xenobiotic metabolism and full recovery of antioxidant capacity of liver cytosol. High level of activity and expression of proteins heme oxygenase and Nrf2 were maintained.
Uskova
M A
MA
Vasil'eva
M A
MA
Trusov
N V
NV
Avrem'eva
L I
LI
Guseva
G V
GV
Aksenov
I V
IV
Kravchenko
L V
LV
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D000975:Antioxidants; D015415:Biomarkers / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D002462:Cell Membrane / Q000201:enzymology / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury; D003600:Cytosol / Q000201:enzymology / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006419:Heme Oxygenase (Decyclizing) / Q000096:biosynthesis; D007780:Lacticaseibacillus casei; D008247:Lysosomes / Q000201:enzymology / Q000473:pathology; D008297:Male; D051267:NF-E2-Related Factor 2 / Q000096:biosynthesis; D051381:Rats
D000975:Antioxidants; D015415:Biomarkers; D051267:NF-E2-Related Factor 2; C495637:Nfe2l2 protein, rat; D002251:Carbon Tetrachloride; D006419:Heme Oxygenase (Decyclizing); D000410:Alanine Transaminase