[Effects and mechanisms of total flavonoids of Litsea coreana on insulin resistance in rats with hyperlipidemia].
OBJECTIVE
To study the effects and its mechanisms of total flavonoids of Litsea coreana (TFLC) on insulin resistance (IR) in rats with hyperlipidemia.


METHODS
The rats were fed with high fat emulsion to make IR models. The effects of TFLC on the state of impaired glucose tolerance (IGT), fasting serum glucose (FSG), fasting serum insulin (FINS), fasting serum lipids (TC, TG, LDL-C, HDL-C), free fatty acid (FFA) and Leptin were observed,and the index of insulin sensitivity (ISI) was calculated.


RESULTS
TFLC could significantly improve the state of IGT and depress the level of FSG, FINS, TC, TG, LDL-C, FFA and leptin of model rats, which could also increase the content of HDL-C and ISI significantly and enhance the sensitivity of insulin.


CONCLUSIONS
TFLC has obvious effects on increasing insulin sensitivity and improving the insulin resistance in rats with hyperlipidemia,which may contribute to the regulating effects on the disturbance of lipid metabolism and the decrease of leptin level.
Lv
Xiong-Wen
XW
School of Pharmacy, Anhui Medical University, Hefei 230032, China. lxw31288@yahoo.com.cn
Li
Jun
J
Jin
Yong
Y
Zhang
Lei
L
Wang
Jian-Qing
JQ
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D005951:Glucose Tolerance Test; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D032862:Litsea / Q000737:chemistry*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D001786:Blood Glucose; D004041:Dietary Fats; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D007328:Insulin; D020738:Leptin; D008055:Lipids