title: Aging, brain disease, and reserve: implications for delirium.
abstract: Cognitive and brain reserve are well studied in the context of age-associated cognitive impairment and dementia. However, there is a paucity of research that examines the role of cognitive or brain reserve in delirium. Indicators (or proxy measures) of cognitive or brain reserve (such as brain size, education, and activities) pose challenges in the context of the long prodromal phase of Alzheimer disease but are diminished in the context of delirium, which is of acute onset. This article provides a review of original articles on cognitive and brain reserve across many conditions affecting the central nervous system, with a focus on delirium. The authors review current definitions of reserve. The authors identify indicators for reserve used in earlier studies and discuss these indicators in the context of delirium. The authors highlight future research directions to move the field ahead. Reserve may be a potentially modifiable characteristic. Studying the role of reserve in delirium can advance prevention strategies for delirium and may advance knowledge of reserve and its role in aging and neuropsychiatric disease generally.
authors.affiliation: Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
authors.forename: Richard N
authors.initials: RN
authors.lastname: Jones
authors.forename: Tamara G
authors.initials: TG
authors.lastname: Fong
authors.forename: Eran
authors.initials: E
authors.lastname: Metzger
authors.forename: Samir
authors.initials: S
authors.lastname: Tulebaev
authors.forename: Frances M
authors.initials: FM
authors.lastname: Yang
authors.forename: David C
authors.initials: DC
authors.lastname: Alsop
authors.forename: Edward R
authors.initials: ER
authors.lastname: Marcantonio
authors.forename: L Adrienne
authors.initials: LA
authors.lastname: Cupples
authors.forename: Gary
authors.initials: G
authors.lastname: Gottlieb
authors.forename: Sharon K
authors.initials: SK
authors.lastname: Inouye
mesh_terms: D000223:Adaptation, Psychological; D000375:Aging / Q000523:psychology*; D001927:Brain Diseases / Q000150:complications*; D003072:Cognition Disorders / Q000523:psychology*; D003693:Delirium / Q000150:complications / Q000473:pathology / Q000523:psychology*; D006801:Humans; D001523:Mental Disorders / Q000150:complications; D009473:Neuronal Plasticity; D012307:Risk Factors