Click chemistry for the synthesis of RGD-containing integrin ligands.
In the last few years click chemistry reactions, and in particular copper-catalyzed cycloadditions, have been used intensively for the preparation of new bioconjugate molecules and materials applicable to biomedical and pharmaceutical areas. This review will be focused on conjugates of the tripeptide Arg-Gly-Asp formed by means of click chemistry reactions. This sequence is a well known binding motif for specific transmembrane proteins and is involved in cellular adhesion to the extracellular matrix, allowing the selective recognition of the biomolecule or polymer in which it is incorporated.
Colombo
Matteo
M
NiKem Research, via Zambeletti 25, 20021 Baranzate, Milan, Italy. matteo.colombo@nikemresearch.com
Bianchi
Aldo
A
D000595:Amino Acid Sequence; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D016023:Integrins / Q000737:chemistry* / Q000378:metabolism*; D008024:Ligands; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry
D001672:Biocompatible Materials; D016023:Integrins; D008024:Ligands; D009842:Oligopeptides; D010455:Peptides; C047981:arginyl-glycyl-aspartic acid