title: Malignant potential of gastrointestinal stromal tumor of the stomach.
abstract: Here, we report the Ki-67 Labeling Index, the expression of c-kit, p53, bcl-2, and apoptosis in 11 gastrointestinal stromal tumors (GISTs). The Ki-67 Labeling Index in the malignant GIST group was higher than that in the benign group. The Ki-67 Labeling Index in the p53-positive cases was higher than that in the p53-negative cases. The Ki-67 Labeling Index in the C-kit-positive group was higher than that in the C-kit-negative group. The bcl-2 expression was not correlated with potential malignancy. The apoptotic count in the bcl-2-positive cases was higher than that in the bcl-2-negative cases. The Ki-67 Labeling Index, the p53 overexpression, and the C-kit expression were useful in predicting the potential malignancy.
authors.affiliation: Department of Surgery, Kurume University, School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka 830-0011, Japan. keishiro@med.kurume-u.ac.jp
authors.forename: Keishiro
authors.initials: K
authors.lastname: Aoyagi
authors.forename: Kikuo
authors.initials: K
authors.lastname: Kouhuji
authors.forename: Shojiro
authors.initials: S
authors.lastname: Yano
authors.forename: Motoshi
authors.initials: M
authors.lastname: Miyagi
authors.forename: Takuya
authors.initials: T
authors.lastname: Imaizumi
authors.forename: Jinryo
authors.initials: J
authors.lastname: Takeda
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shirouzu
mesh_terms: D000368:Aged; D017209:Apoptosis / Q000235:genetics; D016009:Chi-Square Distribution; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D020287:In Situ Nick-End Labeling; D019394:Ki-67 Antigen / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011237:Predictive Value of Tests; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D019009:Proto-Oncogene Proteins c-kit