Towards building a chromosome segregation machine.
All organisms, from bacteria to humans, face the daunting task of replicating, packaging and segregating up to two metres (about 6 x 10(9) base pairs) of DNA when each cell divides. This task is carried out up to a trillion times during the development of a human from a single fertilized cell. The strategy by which DNA is replicated is now well understood. But when it comes to packaging and segregating a genome, the mechanisms are only beginning to be understood and are often as variable as the organisms in which they are studied.
Bloom
Kerry
K
Department of Biology, 622 Fordham Hall, CB3280, University of North Carolina at Chapel Hill, North Carolina 27599, USA. kerry_bloom@unc.edu
Joglekar
Ajit
A
D000818:Animals; D001696:Biomechanical Phenomena; D002455:Cell Division / Q000235:genetics; D002503:Centromere / Q000235:genetics; D002843:Chromatin / Q000378:metabolism; D020090:Chromosome Segregation / Q000235:genetics*; D004247:DNA / Q000737:chemistry; D005057:Eukaryotic Cells / Q000166:cytology* / Q000502:physiology; D006801:Humans; D011387:Prokaryotic Cells / Q000166:cytology* / Q000502:physiology; D021381:Protein Transport; D008941:Spindle Apparatus / Q000378:metabolism; D013816:Thermodynamics
D002843:Chromatin; D004247:DNA