title: Functional evidence confirmed by histological localization: overlapping expression of erythropoietin and HIF-2alpha in interstitial fibroblasts of the renal cortex.
abstract: Erythropoietin (EPO) is the central hormone in the regulation of erythropoiesis. Synthesis of EPO and its constitutive release into the circulation are controlled by the transcriptional activity of the EPO gene. A key regulator of EPO is the dimeric hypoxia-inducible transcription factor (HIF), which has three isoforms. Paliege and co-workers provide convincing morphological evidence that it is the HIF-2 isoform that essentially triggers EPO in the kidney, which is the primary source of EPO in the body.
authors.affiliation: Institute of Physiology, University of Regensburg, Regensburg, Germany. hayo@castrop.com
authors.forename: Hayo
authors.initials: H
authors.lastname: Castrop
authors.forename: Armin
authors.initials: A
authors.lastname: Kurtz
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000096:biosynthesis*; D004921:Erythropoietin / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism*; D007668:Kidney / Q000166:cytology* / Q000378:metabolism*; D000099162:Endothelial PAS Domain-Containing Protein 1
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D004921:Erythropoietin; D000099162:Endothelial PAS Domain-Containing Protein 1