WT1 the oncogene: a tale of death and HtrA.
Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic stress. This supports an oncogenic function for WT1, with implications for novel chemotherapeutic avenues.
Essafi
Abdelkader
A
MRC Human Genetics Unit and the Institute for Genetics and Molecular Medicine, Edinburgh EH4 2XU, UK.
Hastie
Nicholas D
ND
D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D016162:Genes, Wilms Tumor / Q000502:physiology*; D000074923:High-Temperature Requirement A Serine Peptidase 2; D006801:Humans; D024101:Mitochondrial Proteins / Q000378:metabolism / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D012697:Serine Endopeptidases / Q000378:metabolism / Q000502:physiology*; D013312:Stress, Physiological; D025721:WT1 Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology
D000970:Antineoplastic Agents; D024101:Mitochondrial Proteins; D025721:WT1 Proteins; D012697:Serine Endopeptidases; C000615914:HTRA2 protein, human; D000074923:High-Temperature Requirement A Serine Peptidase 2