title: Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia.
abstract: BACKGROUND
  The aging population has resulted in more patients living with cardiovascular disease, such as atrial fibrillation (AF). Recent focus has been placed on understanding the long-term consequences of chronic cardiovascular disease, such as a potential increased risk of dementia.
  
  
  OBJECTIVE
  This study sought to determine whether there is an association between AF and dementia and whether their coexistence is an independent marker of risk.
  
  
  METHODS
  A total of 37,025 consecutive patients from the large ongoing prospective Intermountain Heart Collaborative Study database were evaluated and followed up for a mean of 5 years for the development of AF and dementia. Dementia was sub-typed into vascular (VD), senile (SD), Alzheimer's (AD), and nonspecified (ND).
  
  
  RESULTS
  Of the 37,025 patients with a mean age of 60.6 +/- 17.9 years, 10,161 (27%) developed AF and 1,535 (4.1%) developed dementia (179 VD, 321 SD, 347 AD, 688 ND) during the 5-year follow-up. Patients with dementia were older and had higher rates of hypertension, coronary artery disease, renal failure, heart failure, and prior strokes. In age-based analysis, AF independently was significantly associated with all dementia types. The highest risk was in the younger group (<70). After dementia diagnosis, the presence of AF was associated with a marked increased risk of mortality (VD: hazard ratio [HR] = 1.38, P = .01; SD: HR = 1.41, P = .001; AD: HR = 1.45; ND: HR = 1.38, P <.0001).
  
  
  CONCLUSIONS
  AF was independently associated with all forms of dementia. Although dementia is strongly associated with aging, the highest risk of AD was in the younger group, in support of the observed association. The presence of AF also identified dementia patients at high risk of death.
authors.affiliation: Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, Utah 84107, USA. thomas.bunch@imail.org.
authors.forename: T Jared
authors.initials: TJ
authors.lastname: Bunch
authors.forename: J Peter
authors.initials: JP
authors.lastname: Weiss
authors.forename: Brian G
authors.initials: BG
authors.lastname: Crandall
authors.forename: Heidi T
authors.initials: HT
authors.lastname: May
authors.forename: Tami L
authors.initials: TL
authors.lastname: Bair
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Osborn
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Anderson
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Muhlestein
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Horne
authors.forename: Donald L
authors.initials: DL
authors.lastname: Lappe
authors.forename: John D
authors.initials: JD
authors.lastname: Day
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000401:mortality; D001281:Atrial Fibrillation / Q000150:complications* / Q000401:mortality; D015140:Dementia, Vascular / Q000150:complications* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors