title: An outbreak of late-term abortions, premature births, and congenital deformities associated with a bovine viral diarrhea virus 1 subtype b that induces thrombocytopenia.
abstract: Bovine viral diarrhea virus 1 (BVDV-1) subtype b was isolated from premature Holstein calves from a dairy herd that experienced an outbreak of premature births, late-term abortions, brachygnathism, growth retardation, malformations of the brain and cranium, and rare extracranial skeletal malformations in calves born to first-calf heifers. Experimental inoculation of 3 colostrum-deprived calves aged 2-4 months old with this BVDV isolate resulted in thrombocytopenia, lymphopenia, and leukopenia. Outbreaks of brachygnathism are rarely associated with BVDV, and thrombocytopenia is rarely associated with BVDV-1 strains.
authors.affiliation: California Animal Health and Food Safety Laboratory, University of California-Davis, 18830 Road 112, Tulare, CA 93274, USA. pcblanchard@ucdavis.edu
authors.forename: Patricia C
authors.initials: PC
authors.lastname: Blanchard
authors.forename: Julia F
authors.initials: JF
authors.lastname: Ridpath
authors.forename: Jennifer B
authors.initials: JB
authors.lastname: Walker
authors.forename: Sharon K
authors.initials: SK
authors.lastname: Hietala
mesh_terms: D000034:Abortion, Veterinary / Q000821:virology*; D000818:Animals; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000517:prevention & control / Q000821:virology*; D002417:Cattle; D000013:Congenital Abnormalities / Q000662:veterinary* / Q000821:virology; D030241:Diarrhea Virus 1, Bovine Viral / Q000145:classification* / Q000235:genetics; D005260:Female; D010802:Phylogeny; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000662:veterinary; D047928:Premature Birth / Q000662:veterinary*; D013921:Thrombocytopenia / Q000662:veterinary* / Q000821:virology; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D014765:Viral Vaccines