Failure of a glass ionomer to remineralize apatite-depleted dentin.
Remineralization of demineralized dentin lesions adjacent to glass-ionomer cements (GICs) has been reported in the literature. This study tested the hypothesis that a strontium-based GIC can remineralize completely demineralized dentin by nucleation of new apatite crystallites within an apatite-free dentin matrix. Human dentin specimens were acid-etched, bonded with Fuji IX(GP), and immersed in a calcium-and-phosphate-containing 1.5X simulated body fluid (SBF) for 1-4 months. Polyacrylic acid and polyvinylphosphonic acid biomimetic analogs were added to the SBFs to create 2 additional remineralization media. Specimens were processed by transmission electron microscopy (TEM). No apatite deposition could be identified in the completely demineralized dentin in any of the specimens immersed in the 3 remineralization media, despite TEM/EDX evidence of diffusion of ions specific to the strontium-based GIC into the demineralized dentin. The hypothesis was rejected; mineral concentration alone is not a sufficient endpoint for assessing the success of contemporary remineralization strategies.
Kim
Y K
YK
Department of Conservative Dentistry, School of Dentistry, Kyungpook National University, Daegu, Korea.
Yiu
C K Y
CK
Kim
J R
JR
Gu
L
L
Kim
S K
SK
Weller
R N
RN
Pashley
D H
DH
Tay
F R
FR
D001031:Apatites / Q000008:administration & dosage / Q000737:chemistry; D019232:Dental Restoration Failure; D003793:Dental Restoration, Permanent / Q000379:methods*; D003804:Dentin / Q000187:drug effects*; D005899:Glass Ionomer Cements / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D017001:Tooth Demineralization / Q000628:therapy*; D014089:Tooth Remineralization / Q000379:methods*
D001031:Apatites; C439808:Fuji IX GP Fast; D005899:Glass Ionomer Cements