Efficacy and tolerability of admixing 0.3% lidocaine with Dermicol-P35 27G for the treatment of nasolabial folds.
BACKGROUND
Dermicol-P35 27G, an advanced collagen dermal filler, is effective for nasolabial fold (NLF) correction.


OBJECTIVE
To compare the efficacy and tolerance of Dermicol-P35 27G premixed with lidocaine with that of Dermicol-P35 27G injected after topical anesthesia for NLF correction.


METHODS
In a split-face protocol, 10 patients were injected with Dermicol-P35 27G/topical anest:esia or Dermicol-P35 27G/0.3% lidocaine. Patients were monitored for adverse events and for pain using the Thermometer Pain Scale (TPS) and a visual analog scale (VAS). Efficacy was measured using the Modified Fitzpatrick Wrinkle Scale and the Global Aesthetic Improvement Scale.


RESULTS
Patients experienced significantly less pain with Dermicol-P35 27G/0.3% lidocaine than with Dermicol-P35 27G/topical anesthesia (mean clinician-assessed TPS scores +/- standard deviation: 2.0 +/- 0.8 and 5.2 +/- 2.1, respectively, p<.001). Patients reported less discomfort with Dermicol-P35 27G/0.3% lidocaine than with Dermicol-P35 27G/topical anesthesia (mean VAS scores: 2.0 +/- 1.0 and 6.3 +/- 2.0, respectively, p<.001; TPS scores: 2.3 +/- 0.6 and 5.4 +/- 1.2, respectively, p<.001). Both treatments yielded similar efficacy scores and were well tolerated. Adverse events were mild.


CONCLUSIONS
Dermicol-P35 27G/0.3% lidocaine resulted in less pain than Dermicol-P35 27G/topical anesthesia, with no observed reduction in efficacy.
Weinkle
Susan
S
sweinkle@aol.com
D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage*; D003094:Collagen / Q000008:administration & dosage*; D003357:Cosmetic Techniques; D004338:Drug Combinations; D005145:Face / Q000601:surgery; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control*
D000779:Anesthetics, Local; D004338:Drug Combinations; C549013:dermicol-P35 27G; D003094:Collagen; D008012:Lidocaine