Prevalence of asymptomatic bacteriuria in Egyptian children and adolescents with type 1 diabetes mellitus.
The prevalence of asymptomatic bacteriuria (ASB) and associated risk factors were investigated in 100 Egyptian children and adolescents with type 1 diabetes mellitus and 100 age and sex matched healthy controls. All were subjected to clinical evaluation and assessment of mean random blood glucose, mean glycosylated hemoglobin (HbA1c); microalbuminuria and midstream urinary samples were collected for complete urine analysis and two consecutive urine cultures and sensitivity tests. The prevalence of ASB was higher among diabetics than controls (30% versus 14%, p < 0.01) and was more among older age (p = 0.033) and female patients (p < 0.001); especially postpubertal. Microalbuminuria (36.7%) and microvascular complications (50%) were significant risk factors for ASB in patients while metabolic control and disease duration were not relevant to ASB (p > 0.05). Pyuria was a strong predictor of bacteriuria in patients (80%) and controls (100%). The most common isolates were E. coli in patients (30%) and Pseudomonas in controls (57.1%). Gram positive isolates were detected in 46.7% of diabetic patients but not in controls. ASB is more prevalent among type 1 diabetic patients in the pediatric age group. Screening for ASB is warranted in diabetic patients with risk factors especially if pyuria is detected in their urine analysis.
Salem
Mona A
MA
Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
Matter
Randa M
RM
Abdelmaksoud
Abeer A
AA
El Masry
Sherin A
SA
D000293:Adolescent; D000367:Age Factors; D000419:Albuminuria / Q000453:epidemiology; D001437:Bacteriuria / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000382:microbiology; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006090:Gram-Negative Bacteria / Q000302:isolation & purification*; D006094:Gram-Positive Bacteria / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors
D001786:Blood Glucose; D006442:Glycated Hemoglobin