[The GATA family in reproduction].
The GATA family proteins are a group of zinc finger transcription factors that are expressed in human and mammalian animals and play an important role in mammalian organ morphogenesis, cell proliferation and sex differentiation. GATA-4 and GATA-6 have been identified in the ovaries and testes of humans, mice, pigs and chickens. GATA-4 contributes to fetal male gonadal development by regulating the genes that mediate Müllerian duct regression and the onset of testosterone production. GATA-4 and GATA-6 are localized in and regulate the function of the ovarian and testicular somatic cells of fetal mice, especially granulosa cells, thecal cells, Sertoli cells and Leydig cells. GATA-4 is also present in the germ cells of fetal and prepubertal mice.
Jing
Cai-xia
CX
Department of Parasitology, West China School of Preclinical and Forensic Medicine, Sichuan University, Cheng-du, Sichuan 610041, China.
Yang
Jia-zhou
JZ
Ai
Qing-yan
QY
Miao
Nai-zhou
NZ
Zhao
Yu-feng
YF
Wang
Yan-mei
YM
D000818:Animals; D002645:Chickens; D005260:Female; D050991:GATA4 Transcription Factor / Q000378:metabolism*; D050993:GATA6 Transcription Factor / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D010053:Ovary / Q000196:embryology; D012098:Reproduction; D013552:Swine; D013737:Testis / Q000196:embryology; D014157:Transcription Factors / Q000145:classification
D050991:GATA4 Transcription Factor; D050993:GATA6 Transcription Factor; D014157:Transcription Factors