TB or not TB? Fishing for Molecules Making Permissive granulomas.
Focal accumulations of mononuclear cells, called granulomas, are a hallmark of mycobacterial infections. A common misconception is that granulomas are uniformly protective. In transparent zebrafish larvae infected with Mycobacterium marinum, Volkman et al. demonstrate an interaction of mycobacteria with epithelial cells that helps recruit macrophages to the granuloma as "feeder cells."
Ehlers
Stefan
S
Cluster of Excellence Inflammation-at-Interfaces, Microbial Inflammation Research, Research Center Borstel, Parkallee 1, D-23845 Borstel, Germany. sehlers@fz-borstel.de
D000818:Animals; D006099:Granuloma / Q000276:immunology / Q000382:microbiology* / Q000473:pathology*; D008264:Macrophages / Q000276:immunology*; D008954:Models, Biological; D019910:Mycobacterium marinum / Q000276:immunology* / Q000472:pathogenicity*; D015027:Zebrafish / Q000382:microbiology*