title: Study of a high-risk group of stage II colon cancer.
abstract: This study was conducted for the purpose of identifying a high-risk group for recurrence of stage II colon cancer and determine those cases for which postoperative adjuvant chemotherapy for stage II colon cancer is indicated. The subjects of this study consisted of 179 stage II cases and 114 stage IIIa cases among 462 surgical colon cancer cases examined at this department from January 1, 1991 to December 31, 1996 classified as A for the degree of cure, with the exception of m cancer. A nonrecurrence group and a recurrence group of stage II and stage IIIa colon cancer cases were compared on the basis of parameters. Gender, age, and lymph ducts were extracted from multivariate analysis, while age and lymph ducts were extracted from a survival analysis using the Cox proportional hazard model. A high-risk group for recurrence of stage II colon cancer was determined to consist of young men of ly 2.3. Since the nonrecurrence survival rates and survival prognoses of ly 2.3 cases in particular were equivalent to those of stage IIIa, this is considered to be a risk factor for recurrence of stage II colon cancer, and postoperative chemotherapy is believed to be indicated.
authors.affiliation: Department of Surgery II, Tokyo Women's Medical University, School of Medicine, 8-1 Kawadacho, Sinjuku-ku, Tokyo 162-8666, Japan. hirosawa@surg2.twmu.ac.jp
authors.forename: Tomoichiro
authors.initials: T
authors.lastname: Hirosawa
authors.forename: Michio
authors.initials: M
authors.lastname: Itabashi
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Bamba
authors.forename: Shinpei
authors.initials: S
authors.lastname: Ogawa
authors.forename: Noriyasu
authors.initials: N
authors.lastname: Sirotani
authors.forename: Shingo
authors.initials: S
authors.lastname: Kameoka
mesh_terms: D000368:Aged; D003110:Colonic Neoplasms / Q000401:mortality* / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D016016:Proportional Hazards Models