Chorionic villus sampling: analysis of the first 350 singleton pregnancies by a single operator.
OBJECTIVE
To assess factors that might influence the success rate, safety and reliability of chorionic villus sampling (CVS).


METHODS
Analysis of the outcome of 350 cases of CVS (215 transabdominal and 135 transvaginal).


METHODS
The outpatient prenatal diagnosis and therapy laboratory of a university tertiary care centre.


METHODS
350 pregnant women that underwent CVS for prenatal genetic diagnosis between nine and 32 gestational weeks.


RESULTS
Fetal genotype was the most common indication for CVS 45% (158/350). The overall sampling success rate was 98% (343/350). The majority of cases, 92% (322/350), required one or two aspirations. Out of 331 cases in which CVS was successful 305 continued with the pregnancy. Thirty-five had therapeutic termination of their pregnancies and ten resulted in spontaneous abortions. There was an overall fetal loss rate of 1.7% (6/350). Early bleeding complications occurred in 11.4% (40/350). PROM 0.86% (3/350), preterm 5.1% (18/350), and placenta disorders 1.1% (4/350) did not exceed the expected values.


CONCLUSIONS
CVS is a relatively safe and reliable method of prenatal genetic diagnosis. It needs be done by experienced personnel.
Ajayi
G O
GO
Department of Obstetrics & Gynecology, Prenatal Diagnosis & Therapy Centre, College of Medicine, University of Lagos, Surulere, Lagos, Nigeria. prenataldiagnosiscentre@yahoo.com
D015193:Chorionic Villi Sampling / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006785:Hospitals, University; D006801:Humans; D009549:Nigeria; D010044:Outpatient Clinics, Hospital; D011247:Pregnancy; D011446:Prospective Studies; D018084:Ultrasonography, Interventional