title: The GABA(A)-receptor γ2 (GABRG2) gene in obsessive-compulsive disorder.
abstract: OBJECTIVE
  The γ-aminobutyric acid type A (GABA(A)) system may be implicated in obsessive-compulsive disorder, based on its major role in modulation of anxiety and its function as the principal inhibitory neurotransmitter system in the cortex. In addition, glutamatergic/GABAergic mechanisms appear to play a role in the pathophysiology of obsessive-compulsive disorder, making the GABA(A) receptor-γ2 (GABργ2) gene a good candidate for susceptibility in this disorder.
  
  
  METHODS
  118 probands meeting DSM-IV criteria for primary obsessive-compulsive disorder and their available parents were recruited for participation in this study and informed consent was obtained. An NciI restriction site polymorphism in the second intron was genotyped and data was analyzed using the Transmission Disequilibrium Test.
  
  
  RESULTS
  In total, 61 of the participating families were informative (i.e., with at least one heterozygous parent). No biases were observed in the transmission of either of the two alleles (chi² = 0.016, 1 d.f., p = 0.898) to the affected probands in the total sample.
  
  
  CONCLUSIONS
  While these results do not provide support for a major role for the GABA(A) receptor-γ2 in obsessive-compulsive disorder, further investigations of this gene in larger samples are warranted.
authors.affiliation: Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada. peggy.richter@sunnybrook.ca
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Richter
authors.forename: Gwyneth
authors.initials: G
authors.lastname: Zai
authors.forename: Joanna C
authors.initials: JC
authors.lastname: McBride
authors.forename: Emanuela
authors.initials: E
authors.lastname: Mundo
authors.forename: Richard P
authors.initials: RP
authors.lastname: Swinson
authors.forename: James L
authors.initials: JL
authors.lastname: Kennedy
mesh_terms: D000328:Adult; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D011110:Polymorphism, Genetic; D011963:Receptors, GABA-A / Q000235:genetics*
chemical_list: C546279:GABRG2 protein, human; D011963:Receptors, GABA-A