title: Prucalopride for constipation.
abstract: BACKGROUND
  Chronic constipation has a high prevalence, and current medical and pharmacological therapies do not restore normal bowel function in all patients.
  
  
  METHODS
  A PubMed search (1965 - 2009) using the following terms alone or in combination: prucalopride, 5-HT(4), R093877, safety, toxicity, pharmacokinetics, pharmacodynamics, transit, cardiac, hERG, arrhythmia, potassium current, elderly.
  
  
  RESULTS
  Understanding of the mechanisms of action, safety, efficacy and indications for prucalopride in patients with chronic constipation.
  
  
  CONCLUSIONS
  Prucalopride is an efficacious and generally safe, new therapeutic option in the management of chronic constipation.
authors.affiliation: Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), College of Medicine, Mayo Clinic, Charlton 8-110, 200 First St S.W., Rochester, MN 55905, USA. camilleri.michael@mayo.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Camilleri
authors.forename: Annemie
authors.initials: A
authors.lastname: Deiteren
mesh_terms: D000368:Aged; D001572:Benzofurans / Q000627:therapeutic use*; D003248:Constipation / Q000188:drug therapy*; D003672:Defecation; D005772:Gastrointestinal Transit / Q000187:drug effects / Q000235:genetics; D006801:Humans; D054368:Laxatives / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism
chemical_list: D001572:Benzofurans; D054368:Laxatives; C406662:prucalopride; D012701:Serotonin