Developmental function of HMGN proteins.
High mobility group N (HMGN) proteins are the only nuclear proteins known to specifically recognize the generic structure of the 147-bp nucleosome core particle. Both in vitro and in vivo experiments demonstrate that HMGN proteins are involved in epigenetic regulation by modulating chromatin structure and levels of posttranslational modifications of nucleosomal histones. Expression of HMGN proteins is developmentally regulated, and the loss or overexpression of these proteins can lead to developmental abnormalities. This review will focus on the role and on the possible molecular mechanism whereby HMGN proteins affect cellular differentiation and development.
Furusawa
Takashi
T
Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 3122, 9000 Rockville Pike, Bethesda, MD 20892, USA. furusawt@mail.nih.gov
Cherukuri
Srujana
S
D000818:Animals; D002454:Cell Differentiation; D018507:Gene Expression Regulation, Developmental; D048788:Growth and Development; D024001:HMGN Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans
D024001:HMGN Proteins