CD57 expression by T cells in the female genital tract of HIV-zx1 infected women.
Despite an influx of T cells to the cervix during HIV infection, genital T cells are not associated with control of HIV shedding. CD57 expression by T cells has been associated with enhanced migratory potential and CD57+ T cells have been shown to accumulate in tissues during the late stages of HIV disease. We investigated the impact of HIV-infection and clinical status on the expression of CD57 by T cells from the female genital tract in 13 HIV-infected and 5 uninfected women. We found that cervical and blood-derived T cells expressed similar frequencies of CD57. The frequency of CD57 expression by cervical or blood T cells was not associated with clinical status (CD4 counts). No impairment in IFN-gamma production by CD57+ T cells from the genital tract was observed. We conclude that increased T cell senescence does not appear to be a hallmark of genital mucosal HIV-1 infection.
Liebenberg
Lenine J
LJ
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925 Cape Town, South Africa.
Adedeji
Adebayo Lawrence
AL
Martin
Darren P
DP
Gumbi
Pam P
PP
Denny
Lynette
L
Passmore
Jo-Ann S
JA
D018959:CD57 Antigens / Q000096:biosynthesis* / Q000097:blood / Q000276:immunology; D016207:Cytokines / Q000032:analysis / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D018709:Statistics, Nonparametric; D013601:T-Lymphocytes / Q000276:immunology*; D002577:Uterine Cervical Diseases / Q000276:immunology* / Q000821:virology; D019562:Viral Load / Q000276:immunology
D018959:CD57 Antigens; D016207:Cytokines