title: Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease.
abstract: Cholesterol has been implicated in various neurodegenerative diseases. Here we review the connection between cholesterol and Alzheimer's disease (AD), focusing on a recent study that links neuronal cholesterol esterification with biosynthesis of 24(S)-hydroxycholesterol and the fate of human amyloid precursor protein in a mouse model of AD. We also briefly evaluate the potential of ACAT1 as a drug target for AD.
authors.affiliation: Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA. ta.yuan.chang@dartmouth.edu
authors.forename: Ta-Yuan
authors.initials: TY
authors.lastname: Chang
authors.forename: Catherine C Y
authors.initials: CC
authors.lastname: Chang
authors.forename: Elena
authors.initials: E
authors.lastname: Bryleva
authors.forename: Maximillian A
authors.initials: MA
authors.lastname: Rogers
authors.forename: Stephanie R
authors.initials: SR
authors.lastname: Murphy
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D004951:Esterification; D006801:Humans; D006888:Hydroxycholesterols / Q000378:metabolism*; D050356:Lipid Metabolism; D051379:Mice; D019636:Neurodegenerative Diseases / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D012306:Risk
chemical_list: D016564:Amyloid beta-Protein Precursor; D006888:Hydroxycholesterols; D002784:Cholesterol