title: Three-dimensional computed tomographic analysis of airway anatomy.
abstract: OBJECTIVE
  To test the reliability of a 3-dimensional computed tomographic (3D-CT) analysis of airway size and shape and to correlate the 3D-CT findings with lateral cephalometric measurements.
  
  
  METHODS
  Fifteen pairs of preoperative maxillofacial 3D-CT scans and digital lateral cephalograms of patients treated for obstructive sleep apnea were used in the present study. Digital 3D-CT reconstructions were created and 12 measurements of airway size and 4 of shape were analyzed. The posterior airway space (PAS), middle airway space, and hyoid to mandibular plane distances were measured on the cephalograms. We then randomly selected 5 CT scans and 5 cephalograms which were analyzed blindly on 5 separate occasions by 2 investigators (Z.A., J.T.) to establish the intraclass correlation coefficients for inter- and intraexaminer reliability. All 15 pairs of images were used to compute the Pearson correlation coefficients to establish the relationship between the CT and cephalometric measurements.
  
  
  RESULTS
  The intra- and interexaminer reliabilities were high for all CT (0.86 to 1.0 and 0.89 to 1.0, respectively; P < .001) and cephalometric measurements (0.84 to 1.0 and 0.91 to 0.99, respectively; P < .001). The CT measurements retroglossal anteroposterior dimension and distance between the genial tubercle and hyoid exhibited a positive correlation with the PAS (r = .60, P = 02 and r = .54, P = .04, respectively), and the lateral/anteroposterior dimension demonstrated an inverse correlation (r = -.68, P = .01) with the PAS.
  
  
  CONCLUSIONS
  The results of the present study indicate that the 3D-CT and lateral cephalometric measurements we selected are reliable and reproducible. The only cephalometric measurement that exhibited any correlation with the CT parameters was PAS.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA.
authors.forename: Zachary R
authors.initials: ZR
authors.lastname: Abramson
authors.forename: Srinivas
authors.initials: S
authors.lastname: Susarla
authors.forename: James R
authors.initials: JR
authors.lastname: Tagoni
authors.forename: Leonard
authors.initials: L
authors.lastname: Kaban
mesh_terms: D002508:Cephalometry; D003198:Computer Simulation; D004825:Epiglottis / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D006928:Hyoid Bone / Q000000981:diagnostic imaging / Q000473:pathology; D021621:Imaging, Three-Dimensional; D008297:Male; D015588:Observer Variation; D021362:Palate, Hard / Q000000981:diagnostic imaging / Q000473:pathology; D010160:Palate, Soft / Q000000981:diagnostic imaging / Q000473:pathology; D010614:Pharynx / Q000000981:diagnostic imaging / Q000473:pathology*; D015203:Reproducibility of Results; D012137:Respiratory System / Q000000981:diagnostic imaging* / Q000473:pathology*; D020181:Sleep Apnea, Obstructive / Q000000981:diagnostic imaging* / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D014059:Tongue / Q000000981:diagnostic imaging / Q000473:pathology