Synthesis, characterization and cytotoxic activities of the [RuCl2(NO)(dppp)(L)]PF6 complexes.
The synthesis and characterization of ruthenium compounds of the type [RuCl(2)(NO)(dppp)(L)]PF(6) [dppp=1,3-bis(diphenylphosphino)propane; L=pyridine, 4-methylpyridine, 4-phenylpyridine and dimethyl sulfoxide] are described. The complexes were characterized by elemental analysis, UV/Vis and infrared spectroscopy, cyclic voltammetry, and X-ray crystallography for the complexes with the pyridine and 4-methylpyridine ligands. In vitro evaluation of these nitrosyl complexes revealed cytotoxic activity from 7.1 to 19.0 microM against the MDA-MB-231 breast tumor cells and showed that, in this case, they are more active than the reference metallodrug cisplatin. The 1,3-bis(diphenylphosphino)propane and the N-heterocyclic ligands alone failed to show cytotoxic activities at the concentrations tested (maximum concentration utilized=200 microM).
Golfeto
Camilla C
CC
Departamento de Química, Universidade Federal de São Carlos, CP 676, CEP 13565-905 São Carlos, SP, Brazil.
Von Poelhsitz
Gustavo
G
Selistre-de-Araújo
Heloísa S
HS
de Araujo
Márcio P
MP
Ellena
Javier
J
Castellano
Eduardo E
EE
Lopes
Luiz G L
LG
Moreira
Icaro S
IS
Batista
Alzir A
AA
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects*; D018360:Crystallography, X-Ray; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D055664:Electrochemical Techniques; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry*; D010847:Picolines / Q000737:chemistry*; D011407:Propane / Q000031:analogs & derivatives* / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*; D017975:Ruthenium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012997:Solvents / Q000737:chemistry
D000970:Antineoplastic Agents; D010720:Phosphines; D010847:Picolines; D011725:Pyridines; D017975:Ruthenium Compounds; D012997:Solvents; C467590:1,3-bis(diphenylphosphino)propane; C051448:4-phenylpyridine; D011407:Propane; C515325:4-methylpyridine; D004121:Dimethyl Sulfoxide