title: Coagulation profiling of random-source cats.
abstract: The chemistry and hemostatic parameters of class B vendor cats (Felis catus) can show wide levels of variation, possibly because of initial health status. We compared prothrombin time, partial thromboplastin time, common pathway assay and thrombin time between Class B vendor cats (n = 30) and a control group of healthy cats (n = 16). The antiprotease activities of antiXa, antiIIa, heparin cofactor II, and antithrombin were measured also. Plasma samples from citrated blood were analyzed by using standard clotting assays and commercially available chromogenic substrate assays. Tests for homogeneity of variances and 1-way ANOVA were used to test for significant differences between groups. Results of ANOVA were highly significant between groups for heparin cofactor II and Heptest activity levels. Variances were significantly different between groups for prothrombin time; therefore, an ANOVA was not done. These studies suggest that the class B cats exhibited sufficiently wide variations in their coagulation parameters that they may not be optimal subjects for vascular or cardiovascular research.
authors.affiliation: Department of Comparative Medicine, Loyola University Medical Center, Maywood, Illinois, USA. emcgeehan@lumc.edu
authors.forename: Elizabeth
authors.initials: E
authors.lastname: McGeehan
authors.forename: Karen
authors.initials: K
authors.lastname: Wielgus
authors.forename: Lee
authors.initials: L
authors.lastname: Cera
authors.forename: Farshid
authors.initials: F
authors.lastname: Azarafrooz
authors.forename: Rose
authors.initials: R
authors.lastname: Buesing
authors.forename: Jean
authors.initials: J
authors.lastname: Dubach
authors.forename: Jawed
authors.initials: J
authors.lastname: Fareed
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000830:Animals, Laboratory; D001780:Blood Coagulation Tests / Q000662:veterinary*; D016022:Case-Control Studies; D002415:Cats / Q000097:blood*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D010314:Partial Thromboplastin Time; D011480:Protease Inhibitors / Q000378:metabolism; D011517:Prothrombin Time; D013918:Thrombin Time
chemical_list: D011480:Protease Inhibitors