title: Synthesis and biological evaluation of water-soluble organogermanium.
abstract: Interferon (INF) is an effective drug in treating several human diseases. Ge-132, which is the most common and well-studied organic germanium, has been reported to induce INF-gamma and has undergone clinical trials with promising preclinical results. However, it has been reported that long-term ingestion or high doses of organic Ge-132 causes similar toxic effects as GeO(2) because Ge-132 can be easily contaminated with significant amounts of inorganic germanium during the preparation. In this study, we synthesized the water-soluble organogermanium compound (Ge-OH) without possible contamination with toxic inorganic germanium and showed that Ge-OH is a better INF-gamma inducer than Ge-132 by an animal study.
authors.affiliation: Department of Chemistry, College of Natural Science, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Sumi
authors.initials: S
authors.lastname: Choi
authors.forename: Changwon
authors.initials: C
authors.lastname: Oh
authors.forename: Jeongsoo
authors.initials: J
authors.lastname: Han
authors.forename: Jina
authors.initials: J
authors.lastname: Park
authors.forename: Jee-Hye
authors.initials: JH
authors.lastname: Choi
authors.forename: Na Young
authors.initials: NY
authors.lastname: Min
authors.forename: Kwang-Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Ae Ja
authors.initials: AJ
authors.lastname: Park
authors.forename: Yeo Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Su Jeong
authors.initials: SJ
authors.lastname: Jang
authors.forename: Duck-Hyung
authors.initials: DH
authors.lastname: Lee
authors.forename: Seung Wook
authors.initials: SW
authors.lastname: Ham
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D005857:Germanium / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000494:pharmacology*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D009930:Organic Chemicals; D005857:Germanium; D014867:Water