title: Self-assembling cyclic tetrapeptide from alternating C-linked carbo-beta-amino acid [(S)-beta-Caa] and alpha-aminoxy acid [(R)-Ama]: a selective chloride ion receptor.
abstract: A cyclic tetrapeptide is prepared from alternating (S)-beta-Caa (C-linked carbo-beta-amino acid) and (R)-Ama (alpha-aminoxy acid). Extensive NMR (in CDCl(3) solution) and mass spectral (MS) studies show its halide binding capacity, with a special affinity to the chloride ion. At higher concentration it was found to form molecular aggregates as evidenced from transmission electron microscopic and atomic force microscopic analysis, confirming the formation of nanorods.
authors.affiliation: Organic Chemistry Division III, Indian Institute of Chemical Technology (CSIR), Hyderabad 500 607, India. esmvee@iict.res.in
authors.forename: Gangavaram V M
authors.initials: GV
authors.lastname: Sharma
authors.forename: Vennampalli
authors.initials: V
authors.lastname: Manohar
authors.forename: Samit Kumar
authors.initials: SK
authors.lastname: Dutta
authors.forename: Bojja
authors.initials: B
authors.lastname: Sridhar
authors.forename: Venna
authors.initials: V
authors.lastname: Ramesh
authors.forename: Ragampeta
authors.initials: R
authors.lastname: Srinivas
authors.forename: Ajit C
authors.initials: AC
authors.lastname: Kunwar
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D001665:Binding Sites; D002712:Chlorides / Q000737:chemistry*; D007477:Ions / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D011487:Protein Conformation; D013237:Stereoisomerism; D053719:Tandem Mass Spectrometry
chemical_list: D000596:Amino Acids; D002712:Chlorides; D007477:Ions; D009842:Oligopeptides; D010456:Peptides, Cyclic