Anaplastic oligodendrogliomas after treatment of acute lymphoblastic leukemia in children: report of 2 cases.
Radiation-induced brain tumors are suggested to be the late complication of acute lymphoblastic leukemia (ALL) treatment. High-grade gliomas, meningiomas, and sarcomas are the most frequent neoplasms. Secondary anaplastic oligodendrogliomas are exceedingly rare. Five cases of pure anaplastic oligodendroglioma have been reported in the literature, and only 1 case was in a child after ALL treatment. The authors present 2 cases of pediatric anaplastic oligodendroglioma after treatment of ALL. Furthermore, they performed a molecular cytogenetic study and found loss of 1p in both cases. The authors provide a review of the previous cases and discuss their findings.
Alexiou
George A
GA
Department of Neurosurgery, University of Athens, Athens, Greece. alexiougrg@yahoo.gr
Moschovi
Maria
M
Georgoulis
George
G
Neroutsou
Rosalia
R
Stefanaki
Kalliopi
K
Sfakianos
George
G
Prodromou
Neofytos
N
D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D002648:Child; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis; D019635:Neurosurgical Procedures; D009837:Oligodendroglioma / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects*; D016896:Treatment Outcome
D009363:Neoplasm Proteins