title: Morvan syndrome following B-cell lymphoma.
abstract: Morvan syndrome is a rare autoimmune disease named after the French physician Augustin Marie Morvan. It is characterized by multiple, irregular contractions of the long muscles, weakness, pruritus, hyperhidrosis, insomnia, and delirium. Here, we describe a 17-year-old young man, previously diagnosed with B-cell lymphoma, who presented with multiple asynchronous fasciculations of the long muscles of his lower extremities accompanied by numbness. The patient responded initially to pulse corticosteroids with diminution of the fasciculations. He achieved complete remission following 7 consecutive, monthly intravenous immunoglobulin injections. The present case is described in the context of the available literature.
authors.affiliation: Division of Pediatric Neurology/Pediatric Epilepsy Program, Department of Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon.
authors.forename: Mohamad K
authors.initials: MK
authors.lastname: El-Bitar
authors.forename: Samar A
authors.initials: SA
authors.lastname: Muwakkit
authors.forename: Miguel R
authors.initials: MR
authors.lastname: Abboud
authors.forename: Raja A
authors.initials: RA
authors.lastname: Sawaya
authors.forename: Rose-Mary
authors.initials: RM
authors.lastname: Boustany
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000096:biosynthesis / Q000097:blood; D004568:Electrodiagnosis / Q000379:methods; D005207:Fasciculation / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D006941:Hyperesthesia / Q000276:immunology / Q000503:physiopathology; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009120:Muscle Cramp / Q000276:immunology / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology*; D020385:Myokymia / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology*; D009431:Neural Conduction / Q000276:immunology; D010525:Peripheral Nerves / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D020551:Pulse Therapy, Drug / Q000379:methods; D007319:Sleep Initiation and Maintenance Disorders / Q000276:immunology / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D016756:Immunoglobulins, Intravenous; D008775:Methylprednisolone