title: Synthesis of the conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids.
abstract: The conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids, were prepared by chromatographic separation of diastereomeric dipeptide derivatives formed from N-Boc-L-phenylalanine. Absolute configurations were assigned by X-ray crystallographic analysis.
authors.affiliation: Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721-0041, USA.
authors.forename: Francis N
authors.initials: FN
authors.lastname: Murigi
authors.forename: Gary S
authors.initials: GS
authors.lastname: Nichol
authors.forename: Eugene A
authors.initials: EA
authors.lastname: Mash
mesh_terms: D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D004151:Dipeptides / Q000737:chemistry*; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D010649:Phenylalanine / Q000737:chemistry*; D013237:Stereoisomerism; D014443:Tyrosine / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004151:Dipeptides; D007189:Indans; D014443:Tyrosine; D010649:Phenylalanine