title: Estimating true evolutionary distances under rearrangements, duplications, and losses.
abstract: BACKGROUND
  The rapidly increasing availability of whole-genome sequences has enabled the study of whole-genome evolution. Evolutionary mechanisms based on genome rearrangements have attracted much attention and given rise to many models; somewhat independently, the mechanisms of gene duplication and loss have seen much work. However, the two are not independent and thus require a unified treatment, which remains missing to date. Moreover, existing rearrangement models do not fit the dichotomy between most prokaryotic genomes (one circular chromosome) and most eukaryotic genomes (multiple linear chromosomes).
  
  
  RESULTS
  To handle rearrangements, gene duplications and losses, we propose a new evolutionary model and the corresponding method for estimating true evolutionary distance. Our model, inspired from the DCJ model, is simple and the first to respect the prokaryotic/eukaryotic structural dichotomy. Experimental results on a wide variety of genome structures demonstrate the very high accuracy and robustness of our distance estimator.
  
  
  CONCLUSIONS
  We give the first robust, statistically based, estimate of genomic pairwise distances based on rearrangements, duplications and losses, under a model that respects the structural dichotomy between prokaryotic and eukaryotic genomes. Accurate and robust estimates in true evolutionary distances should translate into much better phylogenetic reconstructions as well as more accurate genomic alignments, while our new model of genome rearrangements provides another refinement in simplicity and verisimilitude.
authors.affiliation: Laboratory for Computational Biology and Bioinformatics, Swiss Federal Institute of Technology (EPFL), EPFL-IIS-LCBB, INJ 230, Station 14, CH-1015 Lausanne, Switzerland. yu.lin@epfl.ch
authors.forename: Yu
authors.initials: Y
authors.lastname: Lin
authors.forename: Vaibhav
authors.initials: V
authors.lastname: Rajan
authors.forename: Krister M
authors.initials: KM
authors.lastname: Swenson
authors.forename: Bernard M E
authors.initials: BM
authors.lastname: Moret
mesh_terms: D019143:Evolution, Molecular; D020440:Gene Duplication; D015321:Gene Rearrangement / Q000235:genetics*; D016678:Genome; D023281:Genomics / Q000379:methods*; D010802:Phylogeny