Retention of Naproxen enantiomers on the chiral stationary phase Whelk-O1 under reversed-phase conditions. A reconsideration of the adsorption mechanism in the light of new experimental data.
A model of adsorption of the Naproxen enantiomers on the (S,S)-Whelk-O1 chiral stationary phase that we recently proposed was found to be inconsistent with new experimental data. A new model taking into account the variation of the dissociation coefficient of the analyte during elution of the band is discussed.
Asnin
Leonid D
LD
Institute of Technical Chemistry, The Ural Branch of the Russian Academy of Sciences, Perm 614990, Russia.
Guiochon
Georges
G
D000327:Adsorption; D056148:Chromatography, Reverse-Phase / Q000295:instrumentation* / Q000379:methods; D009288:Naproxen / Q000737:chemistry*; D012117:Resins, Synthetic / Q000737:chemistry; D013237:Stereoisomerism
D012117:Resins, Synthetic; D009288:Naproxen