title: Inclusion body myositis in a patient with long standing rheumatoid arthritis treated with anti-TNFalpha and rituximab.
abstract: Adult inflammatory myopathies are rare conditions. Amongst them, inclusion body myositis (IBM) is considered to be the most common acquired myopathy in adults above 50 years of age, follows a slowly progressive course, and ultimately leads to severe disability. The case of a 57-year-old patient with long standing rheumatoid arthritis (RA) who developed muscle wasting and weakness of the quadriceps femoris after initiation of anti-TNFalpha treatment is presented. Further workup including muscle biopsy revealed IBM. Initiation of rituximab for continuing synovial inflammation led to remission of RA, but no amelioration of muscle weakness was noted. Although cases of IBM in patients with autoimmune disorders have occasionally been reported and are believed to more favourably respond to immunosuppressive treatment, our patient was unresponsive to glucocorticoids. Furthermore, deterioration of muscle strength was noted with both adalimumab and etanercept treatment. Rituximab, not previously used in IBM, successfully controlled RA, but showed no effect on muscle strength. The present case underlines the therapeutic difficulties in IBM and suggests that anti-TNFalpha therapy might even be deleterious. While an early trial of the lymphocyte-depleting antibody alemtuzumab in IBM showed promising results, selective anti-B-cell-therapy remained without effect in our patient.
authors.affiliation: Department of Endocrinology, Diabetology, and Rheumatology, Heinrich Heine University, Düsseldorf, Germany. stefan.vordenbaeumen@med.uni-duesseldorf.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Vordenbäumen
authors.forename: Eva
authors.initials: E
authors.lastname: Neuen-Jacob
authors.forename: Jutta
authors.initials: J
authors.lastname: Richter
authors.forename: Matthias
authors.initials: M
authors.lastname: Schneider
mesh_terms: D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D058846:Antibodies, Monoclonal, Murine-Derived; D018501:Antirheumatic Agents / Q000494:pharmacology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D015551:Autoimmunity; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D007249:Inflammation; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D018979:Myositis, Inclusion Body / Q000150:complications* / Q000209:etiology*; D052097:Quadriceps Muscle / Q000473:pathology; D012074:Remission Induction; D000069283:Rituximab; D013583:Synovial Membrane / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D018501:Antirheumatic Agents; D007166:Immunosuppressive Agents; D014409:Tumor Necrosis Factor-alpha; D000069283:Rituximab