title: Insomnia in the context of traumatic brain injury.
abstract: Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality in the United States. One of the most common comorbidities of TBI is the disruption of normal sleep. While often viewed as a nuisance symptom, sleep disruption can delay TBI recovery and negatively affect many of the psychological (e.g., anxiety, depression) and neuromuscular (e.g., pain) sequelae of TBI, decreasing quality of life. Treatment of sleep disruption in the context of TBI is complicated by issues of an altered neuronal milieu, polypharmacy, and the complex relationship between the various comorbidities often found in patients with TBI. Given the growing number of veterans returning from combat with TBI and the elevated risk of comorbid disrupted sleep, both caused by and independent of TBI, a comprehensive review of sleep disruption and its treatment is of great relevance to the Department of Veterans Affairs.
authors.affiliation: VA Palo Alto Health Care System, 3801 Miranda Avenue (151Y), Palo Alto, CA 94304, USA. jzeitzer@stanford.ed
authors.forename: Jamie M
authors.initials: JM
authors.lastname: Zeitzer
authors.forename: Leah
authors.initials: L
authors.lastname: Friedman
authors.forename: Ruth
authors.initials: R
authors.lastname: O'Hara
mesh_terms: D001930:Brain Injuries / Q000150:complications* / Q000534:rehabilitation; D015928:Cognitive Behavioral Therapy; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D017286:Polysomnography; D007319:Sleep Initiation and Maintenance Disorders / Q000150:complications* / Q000188:drug therapy / Q000628:therapy*; D013313:Stress Disorders, Post-Traumatic / Q000150:complications / Q000188:drug therapy; D014728:Veterans
chemical_list: D006993:Hypnotics and Sedatives