[Bone and Men's Health. Androgen replacement therapy and bone metabolism].
During aging process in men, decline of androgen level is involved in symptoms of hypogonadism, and recent findings suggest that sex hormones are crucial for skeletal development and maintenance of bone mineral properties. In practice, androgen replacement therapy has not been established for bone-related symptoms in late onset hypogonadisim or male osteoporosis. Whereas recent evidences suggest that bone mineral properties are improved by androgen replacement therapy in aging male, further studies including large clinical trials are necessary to assess long-term benefits and risks by the therapy.
Ogawa
Sumito
S
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo.
D000058:Accidental Falls; D000375:Aging; D000728:Androgens / Q000627:therapeutic use*; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D020249:Hormone Replacement Therapy; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D012306:Risk; D018570:Risk Assessment
D000728:Androgens