title: Oxidative stress and low dose ionizing radiation.
abstract: The field of radiation biochemistry has provided tremendous impact in recent years as extensive research on free radicals has implicated them in radiation damage. An important offshoot of this field is the branch dealing with radiological protection in medical applications like diagnostic radiology. Hence, we decided to investigate the relationship between oxidative stress and low dose ionizing radiation (x-rays) in the work environment of x-ray technicians (radiographers), by comparing their RBC malondialdehyde, % hemolysis, catalase and plasma vitamin E levels with those of controls. There was a significant increase in the susceptibility of RBCs to hemolysis in radiographers compared to controls. Malondialdehyde and catalase levels were slightly increased in the radiographers, but this did not disturb the steady state concentration of their plasma vitamin E. These findings go in favour of theories stating that exposure to low dose ionizing radiation does cause a greater amount of oxidative stress, than that caused during normal routine metabolic processes.
authors.affiliation: Department of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Bejai, Mangalore - 575 004.
authors.forename: Shilpa S
authors.initials: SS
authors.lastname: Puthran
authors.forename: K
authors.initials: K
authors.lastname: Sudha
authors.forename: Gayathri M
authors.initials: GM
authors.lastname: Rao
authors.forename: Beena V
authors.initials: BV
authors.lastname: Shetty
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism / Q000528:radiation effects*; D006461:Hemolysis / Q000528:radiation effects; D006801:Humans; D008315:Malondialdehyde / Q000097:blood; D016273:Occupational Exposure; D016272:Occupational Health; D018384:Oxidative Stress / Q000528:radiation effects*; D011829:Radiation Dosage; D011872:Radiology Department, Hospital; D014810:Vitamin E / Q000097:blood; D000078329:Workforce
chemical_list: D015415:Biomarkers; D014810:Vitamin E; D008315:Malondialdehyde; D002374:Catalase