title: [Study on the immunogenicity of adeno-vector vaccine against H5N1 influenza A virus].
abstract: OBJECTIVE
  To construct adenovirus vector vaccine against H5N1 influenza virus and study on the immunogenicity.
  
  
  METHODS
  In this study, we amplified hemagglutinin (HA) gene sequence of H5N1 influenza virus (A/Anhui/1/2005), then constructed an adenovirus vector vaccine (Adv-HA), followed by tests in BALB/c mice for the immunogenicity with the vaccine and immunization strategies.
  
  
  RESULTS
  The recombinate Adv-HA vaccine could effectively induce both humoral and cellular immunity against human H5N1 influenza virus.
  
  
  CONCLUSIONS
  The Adv-HA vaccination against H5N1 influenza is a potential strategy and worthy of further investigation.
authors.affiliation: Peking Union Medical College, Beijing 100730, China.
authors.forename: Xiao-guang
authors.initials: XG
authors.lastname: Zhang
authors.forename: Kui-biao
authors.initials: KB
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.forename: Nai-fu
authors.initials: NF
authors.lastname: Wang
authors.forename: Xiao-mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Yun-hu
authors.initials: YH
authors.lastname: Sang
authors.forename: Jie
authors.initials: J
authors.lastname: Dong
authors.forename: Hong
authors.initials: H
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000276:immunology; D000818:Animals; D002460:Cell Line; D005260:Female; D005822:Genetic Vectors / Q000235:genetics / Q000276:immunology; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology* / Q000517:prevention & control* / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D011897:Random Allocation; D014611:Vaccination
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007252:Influenza Vaccines