title: Resting prefrontal hypometabolism and paralimbic hypermetabolism related to verbal recall deficits in euthymic older adults with bipolar disorder.
abstract: OBJECTIVE
  To evaluate deficits of delayed free recall in euthymic older patients with bipolar disorder and relate deficits to resting cerebral metabolism.
  
  
  METHODS
  Two group, between subjects.
  
  
  METHODS
  Outpatient.
  
  
  METHODS
  Participants included 16 older adult (mean age, 58.7 years; SD = 7.5) euthymic outpatients with bipolar disorder (10 Type I and 6 Type II) and 11 healthy comparison subjects (mean age, 58.3 years; SD = 5.2).
  
  
  METHODS
  All participants received resting positron emission tomography with (18)flurodeoxyglucose and, within 10 days, delayed free verbal recall testing with the California Verbal Learning Test II.
  
  
  RESULTS
  Patients with bipolar disorder, relative to healthy comparison subjects, had significantly poorer delayed free verbal recall. In patients with bipolar disorder, relative to healthy comparison subjects, prefrontal hypometabolism (dorsolateral prefrontal cortex) and paralimbic hypermetabolism (hippocampus, parahippocampal gyrus, and superior temporal gyrus) was associated with recall deficits in patients with bipolar disorder. Prefrontal and limbic metabolism were inversely related.
  
  
  CONCLUSIONS
  Our findings demonstrate an association between prefrontal hypometabolism and paralimbic hypermetabolism and verbal memory deficits in euthymic older patients with bipolar disorder. Verbal memory deficits may be a clinical consequence of corticolimbic dysregulation in bipolar disorder, even during euthymia. This suggests that such dysregulation and related deficits could be bipolar disorder traits.
authors.affiliation: UCLA Semel Institute and Department of Psychiatry, Los Angeles, CA 90024-1759, USA. john.brooks@ucla.edu
authors.forename: John O
authors.initials: JO
authors.lastname: Brooks
authors.forename: Allyson C
authors.initials: AC
authors.lastname: Rosen
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Hoblyn
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Woodard
authors.forename: Olya
authors.initials: O
authors.lastname: Krasnykh
authors.forename: Terence A
authors.initials: TA
authors.lastname: Ketter
mesh_terms: D000375:Aging; D001714:Bipolar Disorder / Q000000981:diagnostic imaging / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D001928:Brain Diseases, Metabolic / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008032:Limbic System / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D049268:Positron-Emission Tomography / Q000379:methods; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D019275:Radiopharmaceuticals; D012146:Rest; D014706:Verbal Learning
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18