title: Phytotoxic activity of Salvia x jamensis.
abstract: A study has been carried out on the surface exudate of Salvia x jamensis, which showed a significant phytotoxic activity against Papaver rhoeas L. and Avena sativa L.. Bioguided separation of the exudate yielded active fractions from which 3 beta-hydroxy-isopimaric acid (1), hautriwaic acid (2), betulinic acid (3), 7,8 beta-dihydrosalviacoccin (4), isopimaric acid (5), 14 alpha-hydroxy-isopimaric acid (7), 15,16-epoxy-7 alpha, 10 beta-dihydroxy-clerod-3,13(16),14-trien-17,12;18,19-diolide (8), cirsiliol (5,3',4'-trihydroxy-6,7-dimethoxyflavone, 9) and two new neoclerodane diterpenes (6 and 10) were isolated. The structures of 6 and 10 were identified as 15,16-epoxy-10 beta-hydroxy-clerod-3,13(16),14-trien-17,12;18,19-diolide and 15,16-epoxy-7 alpha,10-dihydroxy-clerod-2,13(16),14-trien-17,12;18,19-diolide respectively on the basis of spectroscopic data analysis. All compounds, but 7, 8 and 10, were active in inhibiting the germination of the tested species.
authors.affiliation: Dipartimento di Chimica e Tecnologie Farmaceutiche e Alimentari, University of Genoa, Genoa, Italy. bisio@dictfa.unige.it
authors.forename: Angela
authors.initials: A
authors.lastname: Bisio
authors.forename: Daniele
authors.initials: D
authors.lastname: Fraternale
authors.forename: Gianluca
authors.initials: G
authors.lastname: Damonte
authors.forename: Enrico
authors.initials: E
authors.lastname: Millo
authors.forename: Anna Paola
authors.initials: AP
authors.lastname: Lanteri
authors.forename: Eleonora
authors.initials: E
authors.lastname: Russo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Romussi
authors.forename: Brunella
authors.initials: B
authors.lastname: Parodi
authors.forename: Donata
authors.initials: D
authors.lastname: Ricci
authors.forename: Nunziatina
authors.initials: N
authors.lastname: De Tommasi
mesh_terms: D018554:Avena / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D002734:Chlorophyll / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D018525:Germination / Q000187:drug effects; D006540:Herbicides / Q000737:chemistry* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D010207:Papaver / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D027544:Salvia / Q000633:toxicity*; D012639:Seeds / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D006540:Herbicides; D002734:Chlorophyll