title: Energy metabolism in Japanese patients with Crohn's disease.
abstract: We investigated energy expenditure in hospitalized patients with Crohn's disease (CD), and determined optimal energy requirements for nutritional therapy. Sixteen patients (5 women and 11 men, mean age 36 year old, mean BMI 18.7 kg/m(2)) and 8 healthy volunteers were enrolled in this study. Measured resting energy expenditure (mREE) levels were determined by indirect calorimetry. The mREEs in CD patients were significantly higher than those of healthy controls (24.4 +/- 2.4 kcal/kg/day vs 21.3 +/- 1.7 kcal/kg/day). However, mREEs in CD patients were significantly lower than predicted REEs (pREEs) calculated by the Harris-Benedict equation (26.4 +/- 2.5 kcal/kg/day). Furthermore, mREE/pREE values were lower in undernourished patients than in well-nourished patients. CD patients had hyper-metabolic statuses evaluated by mREE/body weight, but increased energy expenditure did not contribute to weight loss in these patients. In conclusion, nutritional therapy with 25-30 kcal/ideal body weight/day (calculated by mREE x active factor) may be optimal for active CD patients, while higher energy intake values pose the risk of overfeeding.
authors.affiliation: Division of Clinical Nutrition, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Sasaki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Johtatsu
authors.forename: Mika
authors.initials: M
authors.lastname: Kurihara
authors.forename: Hiromi
authors.initials: H
authors.lastname: Iwakawa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Tsujikawa
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Fujiyama
authors.forename: Akira
authors.initials: A
authors.lastname: Andoh