Sustained attention as a potential endophenotype for bipolar disorder.
OBJECTIVE
Nowadays, it is accepted that to identify the biological basis of psychiatric illnesses it would be useful to deconstruct them into the most basic manifestations, such as cognitive deficits. The aim of this study was to set attention deficit as a stable vulnerability marker of bipolar disorder.


METHODS
Sustained attention was evaluated by the Continuous Performance Test (DS-CPT) in 143 euthymic bipolar patients and 105 controls. To estimate the influence of clinical profile in attention, patients completed a semi-structured interview.


RESULTS
Bipolar patients showed a deficit in attention during euthymic periods. This disturbance correlated with years of evolution, age of onset and age of first hospitalisation; and was not influenced by other clinical data.


CONCLUSIONS
Sustained attention may be considered as an endophenotype of the illness.
Ancín
I
I
Clínico San Carlos Hospital, Biomedical Research Foundation, Madrid, Spain.
Santos
J L
JL
Teijeira
C
C
Sánchez-Morla
E M
EM
Bescós
M J
MJ
Argudo
I
I
Torrijos
S
S
Vázquez-Alvarez
B
B
De La Vega
I
I
López-Ibor
J J
JJ
Barabash
A
A
Cabranes-Díaz
Jose Antonio
JA
D000328:Adult; D001288:Attention; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis* / Q000523:psychology; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000523:psychology; D058068:Endophenotypes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D011594:Psychometrics / Q000706:statistics & numerical data; D011930:Reaction Time; D012016:Reference Values; D015203:Reproducibility of Results