Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia.
Improved treatment of childhood acute lymphoblastic leukemia (ALL) depends on the identification of new molecular markers that are able to predict treatment response and clinical outcome. The development of impaired apoptosis in leukemic cells is one factor that may influence their response to treatment. We investigated the expression of three apoptosis related genes, BCL2L13, CASP8AP2, and Livin, as well as their prognostic significance, in a retrospective study of 90 pediatric ALL patients diagnosed between 1996 and 2007 in Taiwan. Univariant analysis revealed that high expression of BCL2L13 was associated with inferior event-free survival and overall survival (p<0.001 and 0.005, respectively). Multivariate analysis for EFS and OS demonstrated that high expression of BCL2L13 was an independent prognostic factor for childhood ALL in this ethnic group.
Yang
Yung-Li
YL
Department of Laboratory Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Lin
Shu-Rung
SR
Chen
Jiann-Shiuh
JS
Lin
Shu-Wha
SW
Yu
Sung-Liang
SL
Chen
Hsuan-Yu
HY
Yen
Ching-Tzu
CT
Lin
Chien-Yu
CY
Lin
Jing-Fang
JF
Lin
Kai-Hsin
KH
Jou
Shiann-Tarng
ST
Hu
Chung-Yi
CY
Chang
Sheng-Kai
SK
Lu
Meng-Yao
MY
Chang
Hsiu-Hao
HH
Chang
Wan-Hui
WH
Lin
Kuo-Sin
KS
Lin
Dong-Tsamn
DT
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000293:Adolescent; D017209:Apoptosis / Q000235:genetics*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D016016:Proportional Hazards Models; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; C431152:BCL2L13 protein, human; C419866:BIRC7 protein, human; C485604:CASP8AP2 protein, human; D002135:Calcium-Binding Proteins; D051034:Inhibitor of Apoptosis Proteins; D009363:Neoplasm Proteins; D019253:Proto-Oncogene Proteins c-bcl-2