title: Effect of early life exposure to air pollution on development of childhood asthma.
abstract: BACKGROUND
  There is increasing recognition of the importance of early environmental exposures in the development of childhood asthma. Outdoor air pollution is a recognized asthma trigger, but it is unclear whether exposure influences incident disease. We investigated the effect of exposure to ambient air pollution in utero and during the first year of life on risk of subsequent asthma diagnosis in a population-based nested case-control study.
  
  
  METHODS
  We assessed all children born in southwestern British Columbia in 1999 and 2000 (n = 37,401) for incidence of asthma diagnosis up to 34 years of age using outpatient and hospitalization records. Asthma cases were age- and sex-matched to five randomly chosen controls from the eligible cohort. We estimated each individual's exposure to ambient air pollution for the gestational period and first year of life using high-resolution pollution surfaces derived from regulatory monitoring data as well as land use regression models adjusted for temporal variation. We used logistic regression analyses to estimate effects of carbon monoxide, nitric oxide, nitrogen dioxide, particulate matter <or= 10 microm and <or= 2.5 microm in aerodynamic diameter (PM10 and PM2.5), ozone, sulfur dioxide, black carbon, woodsmoke, and proximity to roads and point sources on asthma diagnosis.
  
  
  RESULTS
  A total of 3,482 children (9%) were classified as asthma cases. We observed a statistically significantly increased risk of asthma diagnosis with increased early life exposure to CO, NO, NO2, PM10, SO2, and black carbon and proximity to point sources. Traffic-related pollutants were associated with the highest risks: adjusted odds ratio = 1.08 (95% confidence interval, 1.041.12) for a 10-microg/m3 increase of NO, 1.12 (1.071.17) for a 10-microg/m3 increase in NO2, and 1.10 (1.061.13) for a 100-microg/m3 increase in CO. These data support the hypothesis that early childhood exposure to air pollutants plays a role in development of asthma.
authors.affiliation: School of Population and Public Health, University of British Columbia, British Columbia, Canada.
authors.forename: Nina Annika
authors.initials: NA
authors.lastname: Clark
authors.forename: Paul A
authors.initials: PA
authors.lastname: Demers
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Karr
authors.forename: Mieke
authors.initials: M
authors.lastname: Koehoorn
authors.forename: Cornel
authors.initials: C
authors.lastname: Lencar
authors.forename: Lillian
authors.initials: L
authors.lastname: Tamburic
authors.forename: Michael
authors.initials: M
authors.lastname: Brauer
mesh_terms: D000397:Air Pollution / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced*; D001955:British Columbia; D002248:Carbon Monoxide / Q000009:adverse effects; D016022:Case-Control Studies; D002675:Child, Preschool; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D009585:Nitrogen Dioxide / Q000009:adverse effects; D009589:Nitrogen Oxides / Q000009:adverse effects; D052638:Particulate Matter / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced; D013997:Time Factors; D014481:United States
chemical_list: D009589:Nitrogen Oxides; D052638:Particulate Matter; D002248:Carbon Monoxide; D009585:Nitrogen Dioxide