Advances in neuroimaging of traumatic brain injury and posttraumatic stress disorder.
Improved diagnosis and treatment of traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) are needed for our military and veterans, their families, and society at large. Advances in brain imaging offer important biomarkers of structural, functional, and metabolic information concerning the brain. This article reviews the application of various imaging techniques to the clinical problems of TBI and PTSD. For TBI, we focus on findings and advances in neuroimaging that hold promise for better detection, characterization, and monitoring of objective brain changes in symptomatic patients with combat-related, closed-head brain injuries not readily apparent by standard computed tomography or conventional magnetic resonance imaging techniques.
Van Boven
Robert W
RW
Mild Traumatic Brain Injury Clinic, Irwin Army Community Hospital, 600 Caisson Hill Road, Fort Riley, KS 66442, USA. Robert.vanboven@us.army.mil
Harrington
Greg S
GS
Hackney
David B
DB
Ebel
Andreas
A
Gauger
Grant
G
Bremner
J Douglas
JD
D'Esposito
Mark
M
Detre
John A
JA
Haacke
E Mark
EM
Jack
Clifford R
CR
Jagust
William J
WJ
Le Bihan
Denis
D
Mathis
Chester A
CA
Mueller
Susanne
S
Mukherjee
Pratik
P
Schuff
Norbert
N
Chen
Anthony
A
Weiner
Michael W
MW
D001753:Blast Injuries / Q000175:diagnosis / Q000473:pathology; D001930:Brain Injuries / Q000175:diagnosis* / Q000473:pathology; D056324:Diffusion Tensor Imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D049268:Positron-Emission Tomography; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis* / Q000473:pathology