title: Vascular endothelial growth factor in the aqueous humour in eyes with myopic choroidal neovascularization.
abstract: OBJECTIVE
  To determine the concentration of vascular endothelial growth factor (VEGF) in the aqueous humour of eyes with myopic choroidal neovascularization (mCNV).
  
  
  METHODS
  Aqueous humour samples were obtained from 21 eyes of 21 patients with mCNV and from 21 eyes of 21 patients with cataract without CNV or other ocular or systemic diseases (control group). The VEGF concentration in the aqueous humour was measured using an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The VEGF concentrations in the aqueous humour of eyes with mCNV ranged from < 20.6 to 200 pg/ml (median 35 pg/ml). The concentrations in the control group ranged from 26 to 218 pg/ml (median 100 pg/ml). The difference between the two VEGF concentrations in the aqueous humour was significant (p < 0.001, Mann--Whitney rank sum test).
  
  
  CONCLUSIONS
  The VEGF concentration in the aqueous humour of patients with mCNV is lower than in normal controls. VEGF might localize in or around the CNV in eyes with mCNV.
authors.affiliation: Department of Ophthalmology, Shiga University of Medical Science, Japan. osawada@belle.shiga-med.ac.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Sawada
authors.forename: Hajime
authors.initials: H
authors.lastname: Kawamura
authors.forename: Masashi
authors.initials: M
authors.lastname: Kakinoki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Sawada
authors.forename: Masahito
authors.initials: M
authors.lastname: Ohji
mesh_terms: D000328:Adult; D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D001082:Aqueous Humor / Q000378:metabolism*; D000068258:Bevacizumab; D002386:Cataract / Q000378:metabolism; D020256:Choroidal Neovascularization / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000378:metabolism*; D011446:Prospective Studies; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab