Synthesis, characterization, and cytotoxic activity of novel platinum (II) complexes derived from n-benzyl-ethylenediamine and oxalate.
This work describes the synthesis and characterization of three novel complexes derived from N-benzyl-ethylenediamine and oxalate. Precursor compounds were synthesized by reacting N-benzyl-ethylenediamine with K(2)PtCl(4). Subsequent substitution of chlorides by oxalate led to the final products. Elemental analysis and the infrared, (1)H, (13)C, and (195)Pt NMR spectra of these complexes were provided. The cytotoxic activities were investigated against human non-small cell lung carcinoma (A(549)), mouse non-metastatic cell skin melanoma (B16-F1), mouse metastatic cell skin melanoma (B16-F10), human cell breast adenocarcinoma (MDA-MB-231) and normal cell lines such as baby hamster cell kidney (BHK-21), hamster cell ovary (CHO) and compared to cisplatin and carboplatin under the same experimental conditions. The presence of oxalate as a leaving group conferred an interesting cytotoxicity profile to the complexes in the tested cell lines.
Silva
Heveline
H
Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora-MG, 36036-900, Brazil.
Barra
Carolina V
CV
Rocha
Fillipe V
FV
de Almeida
Mauro V
MV
Cesar
Eloi T
ET
da Silva Siqueira
Luciana M
LM
Lopes
Miriam T P
MT
Fontes
Ana P S
AP
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D016466:CHO Cells; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D006224:Cricetinae; D003412:Cricetulus; D005029:Ethylenediamines / Q000737:chemistry*; D006801:Humans; D051379:Mice; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D010070:Oxalates / Q000737:chemistry*
D000970:Antineoplastic Agents; D056831:Coordination Complexes; D005029:Ethylenediamines; D009944:Organoplatinum Compounds; D010070:Oxalates; C031234:ethylenediamine