Balanced approach of gammadelta T cells to type 2 immunity.
Substantial evidence has been accumulated to indicate that gammadelta T cells take part in type 2 immune responses. It is not yet clear, however, in what capacity. Apparently, gammadelta T cells themselves can not only take the function of follicular T helper (T(H)) cells in certain responses, but also can support responses that are dependent on classical help provided by alphabeta T cells. Furthermore, the gammadelta T cells engage as regulators of T(H2) immunity. Here, we consider two mouse models that depend on type 2 immunity, non-specific airway hyperresponsiveness to methacholine after allergen inhalation challenge and the primary IgE response induced by alum-aided immunization, and examine the function of gammadelta T cells. In either case, gammadelta T cells regulate type 2 immunity through balanced enhancing and inhibitory influences. However, after airway allergen exposure, suppressive gammadelta T cells become dominant. The underlying mechanisms are discussed.
Born
Willi K
WK
Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA. bornw@njhealth.org
Huang
Yafei
Y
Jin
Niyun
N
Huang
Hua
H
O'Brien
Rebecca L
RL
D000485:Allergens / Q000276:immunology; D000818:Animals; D016085:Bronchoconstrictor Agents / Q000009:adverse effects / Q000494:pharmacology; D004195:Disease Models, Animal; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D016210:Methacholine Chloride / Q000009:adverse effects / Q000494:pharmacology; D051379:Mice; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D000485:Allergens; D016085:Bronchoconstrictor Agents; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D016210:Methacholine Chloride; D007073:Immunoglobulin E