The plasma membrane Ca(2+)-ATPase: regulation by PSD-95/Dlg/Zo-1 scaffolds.
Since its first characterization in the erythrocyte membrane the plasma membrane Ca(2+)-ATPase has been well-defined as a ubiquitous mechanism for the efflux of Ca(2+) from eukaryotic cells. With 4 isoforms and potentially 30 splice variants, defining the absolute physiological role of plasma membrane Ca(2+)-ATPase has been difficult and very limited due to the lack of effective blockers/antibodies and difficulties in measuring the activity of individual isoforms. This review highlights recent developments showing that specific plasma membrane Ca(2+)-ATPase isoforms are subject to dynamic regulation by PSD-95/Dlg/Zo-1 scaffold proteins. Such interactions support a new paradigm, that by serving as key players in multifunctional protein complexes, transporters can regulate other signalling processes independent of their primary ion pumping function.
Kruger
Wade A
WA
Health Innovations Research Institute, School of Medical Sciences, RMIT University, Bundoora, Melbourne, PO Box 71, VIC 3083, Australia.
Monteith
Gregory R
GR
Poronnik
Philip
P
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D020013:Calcium Signaling; D002462:Cell Membrane / Q000201:enzymology; D000074288:Discs Large Homolog 1 Protein; D000076122:Disks Large Homolog 4 Protein; D025461:Feedback, Physiological; D051528:Guanylate Kinases; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D046912:Multiprotein Complexes; D010750:Phosphoproteins / Q000378:metabolism*; D053499:Plasma Membrane Calcium-Transporting ATPases / Q000235:genetics / Q000378:metabolism*; D062826:Zonula Occludens-1 Protein
D048868:Adaptor Proteins, Signal Transducing; C513314:DLG1 protein, human; D000074288:Discs Large Homolog 1 Protein; D000076122:Disks Large Homolog 4 Protein; C501447:Dlg4 protein, mouse; D047908:Intracellular Signaling Peptides and Proteins; D007527:Isoenzymes; D008565:Membrane Proteins; D046912:Multiprotein Complexes; D010750:Phosphoproteins; C569042:TJP1 protein, human; C569043:Tjp1 protein, mouse; D062826:Zonula Occludens-1 Protein; D051528:Guanylate Kinases; D053499:Plasma Membrane Calcium-Transporting ATPases