The association between serum levels of oxLDL-lgG and oxLDL-lgM autoantibody with adult acute myeloblastic leukaemia.
OBJECTIVE
To evaluate the relationship between serum antibodies against ox-LDL levels and adult acute myeloblastic leukemia (AML).


METHODS
Forty three patients with AML and 52 normal controls were enrolled in this study in the Department of Hematology, Tumor Center of Qilu Hospital of Shandong University from Feb. 2008 to Mar.2009. Serum lgG and lgM antibodies versus the oxLDL levels were evaluated by ELISA method. Data was analyzed by covariance and binary Logistic regression.


RESULTS
Serum mean levels of oxLDL-lgG in patients (38.92 +/- 21.1259 ug/ml) were significantly lower than in control subjects (78.88 +/- 9.3705 ug/ml); Meanwhile, Serum mean levels of oxLDL-lgM in patients (20.53 +/- 10.2990 IU/L) were significantly higher than in control subjects (10.29 +/- 10.5771 IU/L). Binary logistic regression showed the odds ratios of association of oxLD-lgG and oxLD-lgM with adult AML were 0.72(95%CI: 0.55-0.94) and 1.11(95%CI: 1.01-1.21) respectively after adjusted for potential confounders.


CONCLUSIONS
In the preliminary investigation we found a descensive oxLDL- lgG and an elevated oxLDL-lgM serum levels for the adult AML. Future studies need to confirm the hypothesis whether they related to the development and progression of adult AML.
Li
Hao
H
Tumor Center of Qilu Hospital, Shandong University, Jinan, PR China. haoli611@yahoo.com.cn
Diao
Yu Tao
YT
Li
Hui Qing
HQ
Ma
Qing
Q
Cui
Jia
J
Zhou
Ying Zhi
YZ
Li
Dong
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D016022:Case-Control Studies; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000276:immunology*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged
D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein