title: Microcontroller-driven fluid-injection system for atomic force microscopy.
abstract: We present a programmable microcontroller-driven injection system for the exchange of imaging medium during atomic force microscopy. Using this low-noise system, high-resolution imaging can be performed during this process of injection without disturbance. This latter circumstance was exemplified by the online imaging of conformational changes in DNA molecules during the injection of anticancer drug into the fluid chamber.
authors.affiliation: Institut de Physique des Systèmes Biologiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. sandor.kasas@epfl.ch
authors.forename: S
authors.initials: S
authors.lastname: Kasas
authors.forename: L
authors.initials: L
authors.lastname: Alonso
authors.forename: P
authors.initials: P
authors.lastname: Jacquet
authors.forename: J
authors.initials: J
authors.lastname: Adamcik
authors.forename: C
authors.initials: C
authors.lastname: Haeberli
authors.forename: G
authors.initials: G
authors.lastname: Dietler
mesh_terms: D000388:Air; D000903:Antibiotics, Antineoplastic / Q000737:chemistry; D004269:DNA, Bacterial / Q000737:chemistry; D004278:DNA, Superhelical / Q000737:chemistry; D003630:Daunorubicin / Q000737:chemistry; D004574:Electromagnetic Fields / Q000009:adverse effects; D004867:Equipment Design; D004926:Escherichia coli; D018625:Microscopy, Atomic Force / Q000295:instrumentation*; D055616:Microtechnology / Q000295:instrumentation*; D009690:Nucleic Acid Conformation; D010957:Plasmids / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D004269:DNA, Bacterial; D004278:DNA, Superhelical; D003630:Daunorubicin