Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264.
Bacterial acyl-homoserine lactones upregulated an uncharacterized gene cluster (bta) in Burkholderia thailandensis E264 to produce an uncharacterized polar antibiotic. The antibiotic is identified as a mixture of four bactobolins. Annotation of the bta cluster allows us to propose a biosynthetic scheme for bactobolin and reveals unusual enzymatic reactions for further study.
Seyedsayamdost
Mohammad R
MR
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Chandler
Josephine R
JR
Blodgett
Joshua A V
JA
Lima
Patricia S
PS
Duerkop
Breck A
BA
Oinuma
Ken-Ichi
K
Greenberg
E Peter
EP
Clardy
Jon
J
D054742:Acyl-Butyrolactones / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D019117:Burkholderia / Q000737:chemistry / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D053038:Quorum Sensing
D054742:Acyl-Butyrolactones; D000900:Anti-Bacterial Agents; D001578:Benzopyrans; C547429:bactobolin D; C025268:bactobolin