title: International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants.
abstract: BACKGROUND
  Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected because of their prior evidence of an association with lung cancer. These variants belonged to candidate genes from different cancer-related pathways including inflammation (IL1B), folate metabolism (MTHFR), regulatory function (AKAP9 and CAMKK1), cell adhesion (SEZL6) and apoptosis (FAS, FASL, TP53, TP53BP1 and BAT3).
  
  
  METHODS
  Genotype data from 15 ILCCO case-control studies were available for a total of 8431 lung cancer cases and 11 072 controls of European descent and Asian ethnic groups. Unconditional logistic regression was used to model the association between each variant and lung cancer risk.
  
  
  RESULTS
  Only the association between a non-synonymous variant of TP53BP1 (rs560191) and lung cancer risk was significant (OR = 0.91, P = 0.002). This association was more striking for squamous cell carcinoma (OR = 0.86, P = 6 x 10(-4)). No heterogeneity by center, ethnicity, smoking status, age group or sex was observed. In order to confirm this association, we included results for this variant from a set of independent studies (9966 cases/11,722 controls) and we reported similar results. When combining all these studies together, we reported an overall OR = 0.93 (0.89-0.97) (P = 0.001). This association was significant only for squamous cell carcinoma [OR = 0.89 (0.85-0.95), P = 1 x 10(-4)].
  
  
  CONCLUSIONS
  This study suggests that rs560191 is associated to lung cancer risk and further highlights the value of consortia in replicating or refuting published genetic associations.
authors.affiliation: International Agency for Research on Cancer, Lyon 69008, France.
authors.forename: Therese
authors.initials: T
authors.lastname: Truong
authors.forename: Wiebke
authors.initials: W
authors.lastname: Sauter
authors.forename: James D
authors.initials: JD
authors.lastname: McKay
authors.forename: H Dean
authors.initials: HD
authors.lastname: Hosgood
authors.forename: Carla
authors.initials: C
authors.lastname: Gallagher
authors.forename: Christopher I
authors.initials: CI
authors.lastname: Amos
authors.forename: Margaret
authors.initials: M
authors.lastname: Spitz
authors.forename: Joshua
authors.initials: J
authors.lastname: Muscat
authors.forename: Philip
authors.initials: P
authors.lastname: Lazarus
authors.forename: Thomas
authors.initials: T
authors.lastname: Illig
authors.forename: H Erich
authors.initials: HE
authors.lastname: Wichmann
authors.forename: Heike
authors.initials: H
authors.lastname: Bickeböller
authors.forename: Angela
authors.initials: A
authors.lastname: Risch
authors.forename: Hendrik
authors.initials: H
authors.lastname: Dienemann
authors.forename: Zuo-Feng
authors.initials: ZF
authors.lastname: Zhang
authors.forename: Behnaz Pezeshki
authors.initials: BP
authors.lastname: Naeim
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.forename: Shanbeh
authors.initials: S
authors.lastname: Zienolddiny
authors.forename: Aage
authors.initials: A
authors.lastname: Haugen
authors.forename: Loïc
authors.initials: L
authors.lastname: Le Marchand
authors.forename: Yun-Chul
authors.initials: YC
authors.lastname: Hong
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Duell
authors.forename: Angeline S
authors.initials: AS
authors.lastname: Andrew
authors.forename: Chikako
authors.initials: C
authors.lastname: Kiyohara
authors.forename: Hongbing
authors.initials: H
authors.lastname: Shen
authors.forename: Keitaro
authors.initials: K
authors.lastname: Matsuo
authors.forename: Takeshi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Adeline
authors.initials: A
authors.lastname: Seow
authors.forename: Daniel P K
authors.initials: DP
authors.lastname: Ng
authors.forename: Qing
authors.initials: Q
authors.lastname: Lan
authors.forename: David
authors.initials: D
authors.lastname: Zaridze
authors.forename: Neonilia
authors.initials: N
authors.lastname: Szeszenia-Dabrowska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Lissowska
authors.forename: Peter
authors.initials: P
authors.lastname: Rudnai
authors.forename: Eleonora
authors.initials: E
authors.lastname: Fabianova
authors.forename: Vali
authors.initials: V
authors.lastname: Constantinescu
authors.forename: Vladimir
authors.initials: V
authors.lastname: Bencko
authors.forename: Lenka
authors.initials: L
authors.lastname: Foretova
authors.forename: Vladimir
authors.initials: V
authors.lastname: Janout
authors.forename: Neil E
authors.initials: NE
authors.lastname: Caporaso
authors.forename: Demetrius
authors.initials: D
authors.lastname: Albanes
authors.forename: Michael
authors.initials: M
authors.lastname: Thun
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Landi
authors.forename: Joanna
authors.initials: J
authors.lastname: Trubicka
authors.forename: Marcin
authors.initials: M
authors.lastname: Lener
authors.forename: Jan
authors.initials: J
authors.lastname: Lubinski
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Amélie
authors.initials: A
authors.lastname: Chabrier
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.forename: Rayjean J
authors.initials: RJ
authors.lastname: Hung
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D008875:Middle Aged; D018832:Molecular Chaperones / Q000235:genetics; D016017:Odds Ratio; D000071857:Tumor Suppressor p53-Binding Protein 1
chemical_list: C092009:BAG6 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D018832:Molecular Chaperones; C498301:TP53BP1 protein, human; D000071857:Tumor Suppressor p53-Binding Protein 1; D042965:Methylenetetrahydrofolate Reductase (NADPH2)