Self-assembling cyclic tetrapeptide from alternating C-linked carbo-beta-amino acid [(S)-beta-Caa] and alpha-aminoxy acid [(R)-Ama]: a selective chloride ion receptor.
A cyclic tetrapeptide is prepared from alternating (S)-beta-Caa (C-linked carbo-beta-amino acid) and (R)-Ama (alpha-aminoxy acid). Extensive NMR (in CDCl(3) solution) and mass spectral (MS) studies show its halide binding capacity, with a special affinity to the chloride ion. At higher concentration it was found to form molecular aggregates as evidenced from transmission electron microscopic and atomic force microscopic analysis, confirming the formation of nanorods.
Sharma
Gangavaram V M
GV
Organic Chemistry Division III, Indian Institute of Chemical Technology (CSIR), Hyderabad 500 607, India. esmvee@iict.res.in
Manohar
Vennampalli
V
Dutta
Samit Kumar
SK
Sridhar
Bojja
B
Ramesh
Venna
V
Srinivas
Ragampeta
R
Kunwar
Ajit C
AC
D000596:Amino Acids / Q000737:chemistry*; D001665:Binding Sites; D002712:Chlorides / Q000737:chemistry*; D007477:Ions / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D011487:Protein Conformation; D013237:Stereoisomerism; D053719:Tandem Mass Spectrometry
D000596:Amino Acids; D002712:Chlorides; D007477:Ions; D009842:Oligopeptides; D010456:Peptides, Cyclic