title: Involvement of phosphodiesterases in autoimmune diseases.
abstract: We have previously shown that several phosphodiesterase (PDE) subtypes are up-regulated in muscles and lymph node cells (LNC) of rats with experimental autoimmune myasthenia gravis (EAMG). In the present study we investigated PDE expression during the course of EAMG and experimental allergic encephalomyelitis (EAE) and found that the up-regulated expression of selected PDE subtypes in both experimental models is correlated with disease severity. In EAMG, PDE expression is correlated also with muscle damage. A similar up-regulation of PDE was also observed in the respective human diseases, MG and multiple sclerosis (MS). Our findings suggest that change in PDE expression levels is a general phenomenon in autoimmune diseases and may also be used as a marker for disease severity.
authors.affiliation: Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: Keren
authors.initials: K
authors.lastname: Mizrachi
authors.forename: Revital
authors.initials: R
authors.lastname: Aricha
authors.forename: Tali
authors.initials: T
authors.lastname: Feferman
authors.forename: Neta
authors.initials: N
authors.lastname: Kela-Madar
authors.forename: Ilana
authors.initials: I
authors.lastname: Mandel
authors.forename: Tamar
authors.initials: T
authors.lastname: Paperna
authors.forename: Ariel
authors.initials: A
authors.lastname: Miller
authors.forename: Avraham
authors.initials: A
authors.lastname: Ben-Nun
authors.forename: Sonia
authors.initials: S
authors.lastname: Berrih-Aknin
authors.forename: Miriam C
authors.initials: MC
authors.lastname: Souroujon
authors.forename: Sara
authors.initials: S
authors.lastname: Fuchs
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002648:Child; D004195:Disease Models, Animal; D018450:Disease Progression; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000201:enzymology* / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D009103:Multiple Sclerosis / Q000201:enzymology* / Q000276:immunology / Q000503:physiopathology; D009133:Muscular Atrophy / Q000201:enzymology / Q000276:immunology / Q000503:physiopathology; D009157:Myasthenia Gravis / Q000201:enzymology* / Q000276:immunology / Q000503:physiopathology; D020720:Myasthenia Gravis, Autoimmune, Experimental / Q000201:enzymology* / Q000276:immunology / Q000503:physiopathology; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D011237:Predictive Value of Tests; D051381:Rats; D011917:Rats, Inbred Lew; D012720:Severity of Illness Index; D015854:Up-Regulation / Q000276:immunology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D010727:Phosphoric Diester Hydrolases