Biodegradable poly(alpha-hydroxy acid) polymer scaffolds for bone tissue engineering.
Synthetic graft materials are emerging as a viable alternative to autogenous bone graft and bone allograft for the treatment of critical-sized bone defects. These materials can be osteoconductive but are rarely intrinsically osteogenic, although this can be greatly enhanced by the application of bone morphogenetic proteins (BMPs). This review will discuss the versatility of biodegradable poly(alpha-hydroxy acids) for the delivery of BMPs for bone tissue engineering. Poly(alpha-hydroxy acids) have a considerable potential for customization and adaptability via modification of design parameters, including scaffold architecture, composition, and biodegradability. Different fabrication techniques will also be discussed.
Yu
Nicole Y C
NY
Biomedical Engineering, School of AMME J07, University of Sydney, Sydney, Australia. nicoley@chw.edu.au
Schindeler
Aaron
A
Little
David G
DG
Ruys
Andrew J
AJ
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage; D018786:Bone Substitutes / Q000737:chemistry*; D016503:Drug Delivery Systems; D006880:Hydroxy Acids / Q000737:chemistry*; D008422:Materials Testing; D008863:Microspheres; D010012:Osteogenesis / Q000187:drug effects; D011108:Polymers / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D006880:Hydroxy Acids; D011108:Polymers