title: Effects of a manual medicine treatment procedures on nitric oxide release in 23 healthy adults.
abstract: OBJECTIVE
  The objective of this study was to measure if a manual treatment would alter the levels of exhaled nitric oxide levels in healthy adults.
  
  
  METHODS
  A study was performed using 23 healthy adults (age, 18-30 years). Nitric oxide (NO) was measured amperometrically before and after a manual treatment. The treatment used was a cranial-thoracic trapezius stretch.
  
  
  RESULTS
  In healthy adults, manual manipulation was associated with changes in NO levels in exhaled breath. The level of NO increased from 13.3 +/- 2.09 (SD) to 15.0 +/- 2.95 (SD) ppb (P = .001, based upon the paired t tests of the subjects). The median level of NO before manual manipulation was 13.0 ppb (ranging from 8 to 17ppb); after manual manipulation, it was 16.0 ppb (ranging from 6 to 18 ppb).
  
  
  CONCLUSIONS
  The cranial-thoracic trapezius stretch was associated with an increase in exhaled NO, compared to baseline levels for the subjects in this study.
authors.affiliation: Private Practice, Kiernan Wellness Center, Rockaway Park, NY 11694, USA. nanreik1@aol.com
authors.forename: James E
authors.initials: JE
authors.lastname: Kiernan
mesh_terms: D000293:Adolescent; D000328:Adult; D001944:Breath Tests / Q000295:instrumentation; D004867:Equipment Design; D045853:Exhalation; D006801:Humans; D009126:Muscle Relaxation; D026201:Musculoskeletal Manipulations / Q000379:methods; D009569:Nitric Oxide; D012016:Reference Values; D055815:Young Adult
chemical_list: D009569:Nitric Oxide