title: Cancer chemoprevention locks onto a new polyamine metabolic target.
abstract: Ornithine decarboxylase has a relatively long history as a target for cancer chemoprevention and chemotherapy. Plym Forshell et al. report new evidence (beginning on p. 140 in this issue of the journal) indicating that spermidine synthase, a fellow enzyme of ornithine decarboxylase in polyamine metabolism, is transactivated in part by the MYC gene and is a potential target for chemoprevention of B-cell lymphomas.
authors.affiliation: Arizona Cancer Center and Department of Cell Biology and Anatomy, The University of Arizona, Tucson, USA. egerner@azcc.arizona.edu
authors.forename: Eugene W
authors.initials: EW
authors.lastname: Gerner
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism* / Q000494:pharmacology*; D018890:Chemoprevention / Q000379:methods; D006801:Humans; D016393:Lymphoma, B-Cell / Q000201:enzymology / Q000517:prevention & control*; D011436:Spermidine Synthase / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011436:Spermidine Synthase