title: Therapeutic strategies underpinning the development of novel techniques for the treatment of HIV infection.
abstract: The HIV replication cycle offers multiple targets for chemotherapeutic intervention, including the viral exterior envelope glycoprotein, gp120; viral co-receptors CXCR4 and CCR5; transmembrane glycoprotein, gp41; integrase; reverse transcriptase; protease and so on. Most currently used anti-HIV drugs are reverse transcriptase inhibitors or protease inhibitors. The expanding application of simulation to drug design combined with experimental techniques have developed a large amount of novel inhibitors that interact specifically with targets besides transcriptase and protease. This review presents details of the anti-HIV inhibitors discovered with computer-aided approaches and provides an overview of the recent five-year achievements in the treatment of HIV infection and the application of computational methods to current drug design.
authors.affiliation: College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, China.
authors.forename: Jian J
authors.initials: JJ
authors.lastname: Tan
authors.forename: Xiao J
authors.initials: XJ
authors.lastname: Cong
authors.forename: Li M
authors.initials: LM
authors.lastname: Hu
authors.forename: Cun X
authors.initials: CX
authors.lastname: Wang
authors.forename: Lee
authors.initials: L
authors.lastname: Jia
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Liang
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000627:therapeutic use*; D019468:Disease Management; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D006801:Humans
chemical_list: D019380:Anti-HIV Agents