Physisorbed o-carborane onto lyso-phosphatidylcholine-functionalized, single-walled carbon nanotubes: a potential carrier system for the therapeutic delivery of boron.
A combination of data from ICP-MS, Raman spectroscopy, UV-vis spectrometry, atomic force microscopy, zeta-potential measurements and gel electorphoresis studies has shown that o-carborane may be immobilized on stable aqueous dispersions of lyso-phosphatidylcholine-functionalized single-walled carbon nanotubes, which in turn indicates the potential of such structures for deployment as carrier vehicles in boron neutron capture therapy.
Yannopoulos
S N
SN
Foundation for Research and Technology, Hellas-Institute of Chemical Engineering and High Temperature Chemical Processes-FORTH/ICE-HT, PO Box 1414, GR-26504 Patras, Greece. sny@iceht.forth.gr
Zouganelis
G D
GD
Nurmohamed
S
S
Smith
J R
JR
Bouropoulos
N
N
Calabrese
G
G
Fatouros
D G
DG
Tsibouklis
J
J
D001880:Boranes; D001895:Boron / Q000008:administration & dosage / Q000737:chemistry; D001896:Boron Compounds / Q000008:administration & dosage / Q000737:chemistry*; D016754:Boron Neutron Capture Therapy; D002138:Calibration; D055598:Chemical Phenomena; D016503:Drug Delivery Systems / Q000379:methods*; D004587:Electrophoresis, Agar Gel; D008244:Lysophosphatidylcholines / Q000737:chemistry*; D013058:Mass Spectrometry; D018625:Microscopy, Atomic Force; D037742:Nanotubes, Carbon / Q000737:chemistry*; D013059:Spectrum Analysis, Raman
D001880:Boranes; D001896:Boron Compounds; D008244:Lysophosphatidylcholines; D037742:Nanotubes, Carbon; D001895:Boron