Future approaches in periodontal regeneration: gene therapy, stem cells, and RNA interference.
Periodontal disease is a major public health issue and the development of effective therapies to treat the disease and regenerate periodontal tissue is an important goal of today's medicine. This article highlights recent scientific advancements in gene therapy, stem cell biology, and RNA interference with the intent of identifying their potential in periodontal tissue regeneration. Results from basic research, preclinical, and clinical studies indicate that these fields of research may soon contribute to more effective regenerative therapies for periodontal disease.
Intini
Giuseppe
G
Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, REB 513, Boston, MA 02115, USA. giuseppe_intini@hsdm.harvard.edu
D000818:Animals; D001861:Bone Regeneration / Q000235:genetics; D015316:Genetic Therapy; D006801:Humans; D010012:Osteogenesis / Q000235:genetics; D017622:Periodontal Attachment Loss / Q000601:surgery / Q000628:therapy*; D034622:RNA Interference; D012038:Regeneration / Q000235:genetics / Q000502:physiology; D033581:Stem Cell Transplantation