The physiological stimulus for the BarA sensor kinase.
The two-component signal transduction system (TCS) BarA/UvrY activates transcription of CsrB and CsrC noncoding RNAs, which act by sequestering the RNA-binding global regulatory protein CsrA. Here, we show that the metabolic end products formate and acetate provide a physiological stimulus for this TCS and thus link posttranscriptional regulation by the Csr system to the metabolic state of the cell.
Chavez
Ricardo Gonzalez
RG
Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Alvarez
Adrian F
AF
Romeo
Tony
T
Georgellis
Dimitris
D
D019342:Acetic Acid / Q000378:metabolism; D004926:Escherichia coli / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000502:physiology*; D005561:Formates / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D008565:Membrane Proteins / Q000502:physiology*; D010770:Phosphotransferases / Q000502:physiology*; D015398:Signal Transduction
D029968:Escherichia coli Proteins; D005561:Formates; D008565:Membrane Proteins; C030544:formic acid; C074276:barA protein, E coli; D010770:Phosphotransferases; D019342:Acetic Acid