title: Palmadorins A--C, diterpene glycerides from the antarctic nudibranch Austrodoris kerguelenensis.
abstract: The nudibranch Austrodoris kerguelenensis is distributed widely around the Antarctic coast and continental shelves. Earlier collections from McMurdo Sound and the Weddell Sea shelf have afforded a suite of diterpene glyceride esters, a compound class implicated as a chemical defense in nudibranchs. The present chemical investigation of A. kerguelenensis collected near Palmer Station on the Western Antarctic Peninsula has revealed additional examples, palmadorins A-C (1-3), as the first three members of a new series of clerodane diterpenes. In this paper we describe their isolation, structure elucidation, and stereochemical analysis using a combination of one- and two-dimensional NMR spectroscopy and wet chemical methods.
authors.affiliation: Department of Chemistry and Center for Molecular Diversity in Drug Design, Discovery and Delivery, University of South Florida, Tampa, Florida 33620, USA.
authors.forename: Thushara
authors.initials: T
authors.lastname: Diyabalanage
authors.forename: Katrin B
authors.initials: KB
authors.lastname: Iken
authors.forename: James B
authors.initials: JB
authors.lastname: McClintock
authors.forename: Charles D
authors.initials: CD
authors.lastname: Amsler
authors.forename: Bill J
authors.initials: BJ
authors.lastname: Baker
mesh_terms: D000818:Animals; D000864:Antarctic Regions; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D049851:Gastropoda / Q000737:chemistry*; D005989:Glycerides / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D004224:Diterpenes; D005989:Glycerides; C548926:palmadorin A; C548927:palmadorin B; C548928:palmadorin C