Essential oils from two Lantana species with antimycobacterial activity.
Lantana trifolia L. and L. fucata Lindl. are two Brazilian species used in folk medicine for the treatment of respiratory disorders. The composition of the essential oils from the leaves was investigated, as well as their in vitro activity against Mycobacterium tuberculosis. L. trifolia yielded an oil (0.2%) rich in sesquiterpenes. The major substances found were germacrene D (45.1%), (E)-caryophyllene (12.8%), bicyclogermacrene (12.7%) and alpha-humulene (4.4%). Sesquiterpenes were also the main components of the oil of L. fucata (0.3% yield), the principal ones being beta-elemene (27.1%), germacrene D (11.6%), (E)-caryophyllene (7.7%), valencene (5.7%) and germacrene A (4.6%). Both oils exhibited in vitro antimycobacterial activity by the MABA assay with MICs of 80 microg/mL for L. trifolia and 100 microg/mL for L. fucata.
Julião
Lisieux de Santana
Lde S
Programa de Biotecnologia Vegetal, Universidade Federal do Rio de Janeiro, CCS, Bl. K. 2 andar, Rio de Janeiro, RJ, Brazil.
Bizzo
Humberto R
HR
Souza
Andressa M
AM
Lourenço
Maria Cristina S
MC
Silva
Pedro Eduardo A
PE
Tavares
Eliana S
ES
Rastrelli
Luca
L
Leitão
Suzana Guimarães
SG
D000995:Antitubercular Agents / Q000494:pharmacology*; D001938:Brazil; D008401:Gas Chromatography-Mass Spectrometry; D032410:Lantana / Q000737:chemistry*; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry
D000995:Antitubercular Agents; D009822:Oils, Volatile