title: Pellino enhances innate immunity in Drosophila.
abstract: The innate immune response is a defense mechanism against infectious agents in both vertebrates and invertebrates, and is in part mediated by the Toll pathway. Toll receptor activation upon exposure to bacteria causes stimulation of Pelle/IRAK kinase, eventually resulting in translocation of the transcription factor NF-kappaB to the nucleus. Here we show that Pellino, a highly conserved protein interacting with activated Pelle/IRAK, acts as a positive regulator of innate immunity in Drosophila.
authors.affiliation: Department of Biology, McGill University, 1205 Dr. Penfield Avenue, Montreal, Que., Canada H3A 1B1.
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Haghayeghi
authors.forename: Amila
authors.initials: A
authors.lastname: Sarac
authors.forename: Stefan
authors.initials: S
authors.lastname: Czerniecki
authors.forename: Jörg
authors.initials: J
authors.lastname: Grosshans
authors.forename: Frieder
authors.initials: F
authors.lastname: Schöck
mesh_terms: D000818:Animals; D015153:Blotting, Western; D004330:Drosophila / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology*; D053592:Interleukin-1 Receptor-Associated Kinases / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology
chemical_list: D029721:Drosophila Proteins; D009687:Nuclear Proteins; C079896:pll protein, Drosophila; D053592:Interleukin-1 Receptor-Associated Kinases; D017346:Protein Serine-Threonine Kinases