title: Myeloma cells with asurophilic granules--an unusual morphological variant--case presentation.
abstract: We present the case of an 80-year-old man who was admitted for anemia, back pain and progressive weakness. After a workup of clinical and laboratory data, the final diagnosis was multiple myeloma. The bone marrow aspirate revealed 53% myeloma cells with peculiar and rare morphological features: numerous large asurophilic--bright red granules--mucopolizaccharides and immunoglobulins secreted and accumulated in the endoplasmic reticulum, typically known as Russel bodies.
authors.affiliation: University of Medicine and Pharmacy Carol Davila, Clinic of Hematology Universitary Emergency Hospital, Bucharest.
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Vlădăreanu
authors.forename: Diana
authors.initials: D
authors.lastname: Cîşleanu
authors.forename: Mihaela
authors.initials: M
authors.lastname: Derveşteanu
authors.forename: Minodora
authors.initials: M
authors.lastname: Onisâi
authors.forename: Horia
authors.initials: H
authors.lastname: Bumbea
authors.forename: Sînziana
authors.initials: S
authors.lastname: Radeşi
authors.forename: Mădălina
authors.initials: M
authors.lastname: Begu
authors.forename: Băluţă
authors.initials: B
authors.lastname: Cristina
mesh_terms: D000369:Aged, 80 and over; D001854:Bone Marrow Cells / Q000473:pathology*; D003594:Cytoplasmic Granules / Q000473:pathology; D005598:Fractures, Spontaneous / Q000473:pathology; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009101:Multiple Myeloma / Q000000981:diagnostic imaging / Q000473:pathology*; D010950:Plasma Cells / Q000473:pathology*; D011859:Radiography; D016103:Spinal Fractures / Q000473:pathology