title: Advances in sonographic detection of ovarian cancer: depiction of tumor neovascularity with microbubbles.
abstract: OBJECTIVE
  The purpose of this article is to discuss and illustrate the use of contrast-enhanced transvaginal sonography for the early detection of ovarian cancer and suggest how this technique may best be used to distinguish benign from malignant ovarian masses.
  
  
  CONCLUSIONS
  Microbubble-enhanced transvaginal sonography can enhance the evaluation of ovarian masses by early detection of tumor microvascularity.
authors.affiliation: Department of Radiology and Imaging Sciences, Vanderbilt University Medical Center, Nashville, TN 37232-2675, USA. arthur.fleischer@vanderbilt.edu
authors.forename: Arthur C
authors.initials: AC
authors.lastname: Fleischer
authors.forename: Andrej
authors.initials: A
authors.lastname: Lyshchik
authors.forename: Rochelle F
authors.initials: RF
authors.lastname: Andreotti
authors.forename: Misun
authors.initials: M
authors.lastname: Hwang
authors.forename: Howard W
authors.initials: HW
authors.lastname: Jones
authors.forename: David A
authors.initials: DA
authors.lastname: Fishman
mesh_terms: D003287:Contrast Media; D005260:Female; D005466:Fluorocarbons; D006801:Humans; D021621:Imaging, Three-Dimensional; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging*; D010743:Phospholipids; D012680:Sensitivity and Specificity; D013459:Sulfur Hexafluoride; D018608:Ultrasonography, Doppler / Q000379:methods*
chemical_list: D003287:Contrast Media; D005466:Fluorocarbons; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride; C042852:perflutren