title: HAL fluorescence cystoscopy and TURB one year of Romanian experience.
abstract: Hexaminolevulinate blue light cystoscopy (HAL-BLC) represents an increasingly acknowledged method in bladder cancer diagnostic. We aimed to evaluate the importance of this procedure in cases of non-invasive bladder tumors (NIBT), to compare it with standard white light cystoscopy (WLC), and to establish the efficiency of blue light transurethral bladder resection (BL-TURB). Between December 2007 and December 2008, WLC and BLC were performed in 70 cases. WL-TURB was performed for all lesions visible in WL, and BL-TURB for those only detected in BL. Patients diagnosed with NIBT were followed-up after an average period of 5 months (between 18 and 22 weeks) by WLC and BLC. The control group included the same number of consecutive cases of NIBT, which underwent only WLC and WL-TURB, as well as the same follow-up protocol as the study group. WLC correctly identified 115 tumors, and BLC, 157 tumors. The detection rate was 68.8% for WLC, with a 9.4% rate of false-positive results, and 94% for BLC, with a 14.6% rate of false-positive results. The diagnostic accuracy in CIS lesions was 57.3% for WLC and 95% for BLC, while in pTa tumors; it was 68.8% for WLC and 94% for BLC. 62 cases of the study group diagnosed with NIBT emphasized a recurrence rate of 6.4% after 5 months. The control group described a recurrence rate of 24.2%. HAL fluorescence cystoscopy is a valuable diagnostic method for patients with NIBT, with considerably improved accuracy by comparison to WLC, and a significant impact upon the short-term recurrence rate.
authors.affiliation: "Saint Iohn" Clinical Emergency Hospital, Department of Urology, 13 Vitan Barzesti Street, Sector 4, Code: 042122, Bucharest, Romania. bogdan_geavlete@yahoo.com
authors.forename: B
authors.initials: B
authors.lastname: Geavlete
authors.forename: R
authors.initials: R
authors.lastname: Mulţescu
authors.forename: D
authors.initials: D
authors.lastname: Georgescu
authors.forename: M
authors.initials: M
authors.lastname: Jecu
authors.forename: P
authors.initials: P
authors.lastname: Geavlete
mesh_terms: D003558:Cystoscopy / Q000379:methods*; D005189:False Positive Reactions; D006801:Humans; D008856:Microscopy, Fluorescence / Q000379:methods*; D015203:Reproducibility of Results; D012383:Romania; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D013520:Urologic Surgical Procedures / Q000379:methods; D019459:Urothelium / Q000473:pathology / Q000601:surgery