[Effect of the active component isolated from the alcohol extract of Dioscorea cirrhosa Lour on blood pressure of rats].
OBJECTIVE
To isolate the active component from Dioscorea cirrhosa Lour and test its activity in lowering blood pressure.


METHODS
The serial components were obtained from the total extract, ligroin extract, ethyl acetate, n-butyl alcohol extract and water extract. The isolated active components were administered in rats via the common carotid artery canulation and tail vein injection to test their effects on blood pressure.


RESULTS
The component A isolated and purified from normal butanol showed obvious effect in lowering the blood pressure of rats.


CONCLUSIONS
The isolated active component from Dioscorea cirrhosa Lour possesses obvious blood pressure-lowering activity.
Xia
Cheng-lai
CL
Institute of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. xiachenglai@126.com
Zhong
Chao
C
D000818:Animals; D000959:Antihypertensive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D027742:Dioscorea / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts