title: Effect of bariatric surgery on circulating chemerin levels.
abstract: BACKGROUND
  Subclinical inflammation in obesity is critical for development of several obesity-associated disorders. We set out to investigate the effect of pronounced weight loss on circulating chemerin levels, a chemoattractant protein that also influences adipose cell function by paracrine and autocrine mechanisms.
  
  
  METHODS
  Thirty-two obese patients undergoing bariatric surgery were tested before and on an average of 18 months after gastric banding or gastric bypass surgery.
  
  
  RESULTS
  Pronounced weight loss after bariatric surgery was accompanied by improvements in parameters of lipid and glucose metabolism and increased adiponectin levels. Chemoattractant chemerin significantly decreased from 175.91 +/- 24.50 to 145.53 +/- 26.44 ng mL(-1) after bariatric surgery (P < or = 0.01). Concomitantly, hs-CRP as a marker of subclinical inflammation was significantly reduced after weight reduction (P < or = 0.01).
  
  
  CONCLUSIONS
  We hypothesize that weight-loss induced reduction in circulating chemerin might in conjunction with other factors be associated with diminished recruitment of macrophages in adipose tissue and reduction of subclinical inflammation, which again could partly explain beneficial long-term effects of weight reduction in obese subjects.
authors.affiliation: Department of Medicine I, Medical University Innsbruck, 6020 Innsbruck, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Ress
authors.forename: A
authors.initials: A
authors.lastname: Tschoner
authors.forename: J
authors.initials: J
authors.lastname: Engl
authors.forename: A
authors.initials: A
authors.lastname: Klaus
authors.forename: H
authors.initials: H
authors.lastname: Tilg
authors.forename: C F
authors.initials: CF
authors.lastname: Ebenbichler
authors.forename: J R
authors.initials: JR
authors.lastname: Patsch
authors.forename: S
authors.initials: S
authors.lastname: Kaser
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D050110:Bariatric Surgery; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D018925:Chemokines / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D009765:Obesity / Q000097:blood* / Q000601:surgery; D015431:Weight Loss / Q000502:physiology*
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human; D002097:C-Reactive Protein