title: Birth weight, family history of diabetes, and metabolic syndrome in children and adolescents.
abstract: OBJECTIVE
  To evaluate whether a coupled family history of diabetes (FHD) and low birth weight (LBW) or high birth weight (HBW) is associated with metabolic syndrome (MetS) in children and adolescents.
  
  
  METHODS
  A total of 1262 children and adolescents age 7-15 years were randomly selected to enroll in this cross-sectional, community-based study.
  
  
  RESULTS
  In the overall population, HBW (odds ratio [OR] = 1.4; 95% confidence interval [CI] = 1.2-10.9), but not LBW (OR = 0.97; 95% CI = 0.6-2.1), was significantly associated with MetS. In the group without FHD, HBW (OR = 1.730; 95% CI = 1.1-2.7), but not LBW (OR = 1.139; 95% CI = 0.7-23), was associated with MetS. In the group with FHD, both LBW (OR = 2.690; 95% CI = 1.4-15.1) and HBW (OR = 3.289; 95% CI = 1.3-30.6) were associated with MetS. Both LBW (OR = 4.710; 95% CI = 1.4-39.7) and HBW (OR = 3.127; 95% CI = 1.3-45.1) were associated with MetS in children and adolescents with FHD in the maternal branch but not in the paternal branch.
  
  
  CONCLUSIONS
  HBW or LBW, in combination with positive FHD in the maternal branch, are determinants of MetS.
authors.affiliation: Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico.
authors.forename: Fernando
authors.initials: F
authors.lastname: Guerrero-Romero
authors.forename: Celia
authors.initials: C
authors.lastname: Aradillas-García
authors.forename: Luis E
authors.initials: LE
authors.lastname: Simental-Mendia
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Monreal-Escalante
authors.forename: Esperanza
authors.initials: E
authors.lastname: de la Cruz Mendoza
authors.forename: Martha
authors.initials: M
authors.lastname: Rodríguez-Moran
mesh_terms: D000293:Adolescent; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology*; D012307:Risk Factors; D012959:Socioeconomic Factors
chemical_list: D001786:Blood Glucose; D008055:Lipids