Bioluminescence tomography based on the phase approximation model.
A reconstruction method of bioluminescence sources is proposed based on a phase approximation model. Compared with the diffuse approximation, this phase approximation model more correctly predicts bioluminescence photon propagation in biological tissues, so that bioluminescence tomography can accurately locate and quantify the distribution of bioluminescence sources. The compressive sensing (CS) technique is applied to regularize the inverse source reconstruction to enhance numerical stability and efficiency. The numerical simulation and phantom experiments demonstrate the feasibility of the proposed approach.
Cong
W
W
Biomedical Imaging Division, School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Stanger Street, Blacksburg, Virginia 24061, USA. congw@vt.edu
Wang
G
G
D000162:Acoustics; D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D020342:Finite Element Analysis; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008156:Luciferases / Q000378:metabolism; D008163:Luminescent Measurements / Q000379:methods*; D015233:Models, Statistical; D008962:Models, Theoretical; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D017785:Photons; D048790:Renilla; D014054:Tomography / Q000379:methods*
D008156:Luciferases