title: Evolving carbapenemases: can medicinal chemists advance one step ahead of the coming storm?
authors.affiliation: Chemistry Department and Center for Macromolecular Modeling and Materials Design, California State Polytechnic University, Pomona, California, USA. oelschlaeger@csupomona.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Oelschlaeger
authors.forename: Ni
authors.initials: N
authors.lastname: Ai
authors.forename: Kevin T
authors.initials: KT
authors.lastname: Duprez
authors.forename: William J
authors.initials: WJ
authors.lastname: Welsh
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Toney
mesh_terms: D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D015780:Carbapenems / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D016208:Databases, Factual; D015195:Drug Design; D024901:Drug Resistance, Multiple, Bacterial; D007711:Klebsiella pneumoniae / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D008667:Metalloproteins / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D008958:Models, Molecular; D009154:Mutation; D011487:Protein Conformation; D013379:Substrate Specificity; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D008667:Metalloproteins; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases; C063912:carbapenemase; C531581:carbapenemase-2, Klebsiella pneumoniae