DNA microarray analysis of genomic responses of yeast Saccharomyces cerevisiae to nickel chloride.
In order to investigate nickel toxicity against the yeast Saccharomyces cerevisiae, genomic responses to nickel chloride were examined using yeast DNA microarrays. Microarray analysis revealed that exposure to 25 mM nickel chloride for 2 hr induced changes in gene expression in S. cerevisiae. Nickel chloride increased expression levels in 601 genes and decreased expression levels in 696 genes in S. cerevisiae.
Takumi
Shota
S
Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto.
Kimura
Hirokazu
H
Matsusaki
Hiromi
H
Kawazoe
Sadahiro
S
Tominaga
Nobuaki
N
Arizono
Koji
K
D004271:DNA, Fungal / Q000032:analysis / Q000187:drug effects; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects*; D015966:Gene Expression Regulation, Fungal / Q000187:drug effects; D023281:Genomics; D009152:Mutagenicity Tests; D009532:Nickel / Q000633:toxicity*; D020411:Oligonucleotide Array Sequence Analysis; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development
D004271:DNA, Fungal; C022838:nickel chloride; D009532:Nickel