title: [Controlled clinical trials of external using of Cheezheng Qingpeng ointment on reliving analgesia and swelling for the treatment of rheumatoid arthritis].
abstract: OBJECTIVE
  To observe the clinical efficacy on analgesia and detumescence of Cheezheng Qingpeng ointment in the treatment of rheumatoid arthritis.
  
  
  METHODS
  From December 2004 to May 2006, 78 patients were divided into the treatment group and the control group randomly using PROC PLAN from SAS software. There were 40 patients in the treatment group, 30 patients were male and 10 patients were female, with an average age of (48.2+/-9.7) years, who were treated with Cheezheng Qingpeng ointment external treatment. Thirty-eight patients were in the control group, 30 patients were male and 8 patients were female, with an average age of (47.7+/-13.7) years, and were treated with Diclofenac diethylamine emugel. All the patients were treated for 2 weeks. The metacarpophalangeal joint with most severe pain and swelling was observed. The indexes including joint pain, tenderness, swelling, joint motion and morning stiffness were detected and the VAS scores were compared between the two groups.
  
  
  RESULTS
  All the patients completed the trial, 35 patients in the treatment group and 33 patients in the control group. At the end of 2 weeks, 1 patient in the treatment group obtained an excellent result, 27 good and 7 bad; in the control group, 2 patients got an excellent result, 20 good and 11 bad. There were no statistically difference of therapeutic effects between the two groups. At the 1st week after treatment, the joint swelling score of the treatment group was (4.0+/-1.4), which was lower than the (5.5+/-1.9) in the control group.
  
  
  CONCLUSIONS
  There is no obvious difference of therapeutic effects between Cheezheng Qingpeng ointment and diclofenac diethylamine emugel for the treatment of rheumatoid arthritis, but the relieving of swelling of Cheezheng Qingpeng ointment is better than that of Diclofenac Diethylamine Emugel.
authors.affiliation: The Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beiling 100091, China.
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: Zhou
authors.forename: Zheng
authors.initials: Z
authors.lastname: Pan
authors.forename: Fang
authors.initials: F
authors.lastname: Ma
authors.forename: Jin-Yang
authors.initials: JY
authors.lastname: Tang
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy*
chemical_list: D004365:Drugs, Chinese Herbal; D009824:Ointments