Disappearance of carbon monoxide from the blood: Comparison of the one-exponential and two-exponential elimination models for rat.
The elimination of carbon monoxide from rat blood was studied from a starting point of a nonsteady-state concentration of 40% for carboxyhemoglobin (COHb). The accuracy of the fit was statistically improved by the employment of a two-exponential elimination model rather than that of the one-exponential model. Yet, the differences in the COHb estimates attained with the two models were negligible. Therefore, for practical purposes, the one-exponential model seems reasonably reliable for estimating COHb.
Kurppa
K
K
Department of Epidemiology and Biometry, Institute of Occupational Health, Helsinki, Finland.
D000818:Animals; D002248:Carbon Monoxide / Q000493:pharmacokinetics*; D002263:Carboxyhemoglobin / Q000378:metabolism*; D004195:Disease Models, Animal; D016018:Least-Squares Analysis; D008297:Male; D008657:Metabolic Clearance Rate; D051381:Rats; D017208:Rats, Wistar
D002248:Carbon Monoxide; D002263:Carboxyhemoglobin