Polyketides from marine dinoflagellates of the genus Prorocentrum, biosynthetic origin and bioactivity of their okadaic acid analogues.
Marine dinoflagellates of the genus Prorocentrum are famous for the production of okadaic acid (OA) and its analogues. This review covers first the source, chemistry and bioactivity of polyketides from Prorocentrum species. Then recent advances in the studies of biosynthetic origin of OA and its analogues are included. Moreover, the pharmacophore for the selective inhibition of OA to protein phosphatases types 1 (PP1) and 2A (PP2A) is highlighted.
Hu
Weimin
W
Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, China.
Xu
Jing
J
Sinkkonen
Jari
J
Wu
Jun
J
D000818:Animals; D020134:Catalytic Domain; D004141:Dinoflagellida / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D008387:Marine Toxins / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019319:Okadaic Acid / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D011485:Protein Binding; D054645:Protein Phosphatase 1 / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology; D054648:Protein Phosphatase 2 / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology; D013045:Species Specificity
D004791:Enzyme Inhibitors; D018942:Macrolides; D008387:Marine Toxins; D019319:Okadaic Acid; D054645:Protein Phosphatase 1; D054648:Protein Phosphatase 2