title: Diamination by N-coupling using a commercial laccase.
abstract: Nuclear diamination of p-hydrobenzoquinones with aromatic and aliphatic primary amines was catalysed by an immobilised commercial laccase, Denilite II Base, from Novozymes. The amine and the p-hydrobenzoquinone was reacted under mild conditions (at room temperature and at 35 degrees C) in a reaction vessel open to air in the presence of laccase and a co-solvent to afford, exclusively, the diaminated p-benzoquinone. These compounds may have potential antiallergic, antibiotic, anticancer, antifungal, antiviral and/or 5-lipoxygenase inhibiting activity.
authors.affiliation: CSIR Biosciences, Modderfontein 1645, South Africa. kwellington@csir.co.za
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Wellington
authors.forename: Paul
authors.initials: P
authors.lastname: Steenkamp
authors.forename: Dean
authors.initials: D
authors.lastname: Brady
mesh_terms: D000586:Amination; D016227:Benzoquinones / Q000737:chemistry*; D042845:Laccase / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy
chemical_list: D016227:Benzoquinones; D042845:Laccase