title: Aortic valve-sparing in 37 patients with Marfan syndrome: midterm results with David operation.
abstract: BACKGROUND
  We reviewed our experience with aortic valve-sparing operations in Marfan syndrome during last 5 years.
  
  
  METHODS
  Between March 2004 and June 2009, 94 patients with aortic root aneurysms underwent valve-sparing operations. Of these, 37 (68% male) were diagnosed with Marfan syndrome, according to the Ghent diagnostic criteria. Mean age was 30 +/- 10 years (range, 11 to 59 years). Moderate/severe aortic regurgitation was present in 13%, and the mean diameter of the Valsalva sinuses was 50 +/- 4 mm (range, 42 to 62 mm). The David V modification was performed in the last 28 patients. Additional procedures were mitral valve repair in 6, tricuspid valve repair in 3, closure of septal atrial defect in 2, and closure of a patent foramen ovale in 13. Mean follow-up was 27 +/- 16 months (range, 1 to 61 months).
  
  
  RESULTS
  There were no in-hospital deaths and no major adverse outcomes. One patient required implantation of a mechanical prosthesis during the same procedure because of moderate aortic regurgitation. One late death occurred. No patients required reoperation. In the last follow-up, 23 patients did not have aortic regurgitation, 12 had grade I, and 1 had grade II. No thromboembolic complications have been documented, and 97% of the patients are free from anticoagulation.
  
  
  CONCLUSIONS
  Short-term and midterm results with the reimplantation technique for aortic root aneurysms in Marfan patients are excellent. If long-term results are similar, this technique could be the treatment of choice for these patients.
authors.affiliation: Department of Cardiac Surgery, University Hospital, Madrid, Spain. aforteza.hdoc@salud.madrid.org
authors.forename: Alberto
authors.initials: A
authors.lastname: Forteza
authors.forename: Javier
authors.initials: J
authors.lastname: De Diego
authors.forename: Jorge
authors.initials: J
authors.lastname: Centeno
authors.forename: Maria Jesus
authors.initials: MJ
authors.lastname: López
authors.forename: Enrique
authors.initials: E
authors.lastname: Pérez
authors.forename: Carlos
authors.initials: C
authors.lastname: Martín
authors.forename: Violeta
authors.initials: V
authors.lastname: Sánchez
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Rufilanchas
authors.forename: Jose
authors.initials: J
authors.lastname: Cortina
mesh_terms: D000293:Adolescent; D000328:Adult; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000150:complications / Q000601:surgery*; D008875:Middle Aged; D011474:Prosthesis Design; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult