Familial reactive perforating collagenosis.
BACKGROUND
Reactive perforating collagenosis (RPC) is one of the rare forms of transepidermal elimination in which genetically altered collagen is extruded from the epidermis. This disease usually starts in early childhood as asymptomatic umbilicated papules on extremities, and the lesions become more conspicuous with age.


OBJECTIVE
The objective of our study was to determine the clinico-pathological features of RPC and the response to various treatment modalities.


METHODS
Ten patients of RPC, belonging to five different families, were studied clinically. Various laboratory investigations were carried out and diagnosis was made by histopathology of the lesions. Patients were given various topical and oral treatments.


RESULTS
RPC is familial in most cases without any definite inheritance pattern. It begins in childhood and the lesions are usually recurrent and become profuse and large with age. Systemic diseases have no role in the onset of lesions.


CONCLUSIONS
Oral and topical retinoids in combination with emollients is the best treatment option.
Bhat
Yasmeen J
YJ
Department of Dermatology, STD & Leprosy, SKIMS Medical College Hospital, Srinagar, India. yasmeen_bhat2001@yahoo.co.in
Manzoor
Sheikh
S
Qayoom
Seema
S
Wani
Roohi
R
Baba
Asif Nazir
AN
Bhat
Arshad Hussian
AH