title: [Nelson syndrome: a rare cause of generalized hyperpigmentation of the skin].
abstract: Nelson syndrome is a rare cause of generalized mucocutaneous hyperpigmentation. Its clinical manifestations are due to excessive secretion of adrenocorticotropic hormone from a pituitary adenoma, which develops after bilateral therapeutic adrenalectomy. As this operation has fallen into disuse, Nelson syndrome is now extremely rare and difficult to recognize. We present a very severe case of generalized hyperpigmentation due to Nelson syndrome in a 37-year-old woman.
authors.affiliation: Servicio de Dermatología, Hospitales Universitarios Virgen del Rocío, Sevilla. romanbarabash@hotmail.com
authors.forename: R
authors.initials: R
authors.lastname: Barabash
authors.forename: F G
authors.initials: FG
authors.lastname: Moreno-Suárez
authors.forename: L
authors.initials: L
authors.lastname: Rodríguez
authors.forename: A M
authors.initials: AM
authors.lastname: Molina
authors.forename: J
authors.initials: J
authors.lastname: Conejo-Mir
mesh_terms: D000236:Adenoma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D000315:Adrenalectomy / Q000009:adverse effects*; D000328:Adult; D000077465:Cabergoline; D003131:Combined Modality Therapy; D003998:Dicarboxylic Acids / Q000627:therapeutic use; D004873:Ergolines / Q000627:therapeutic use; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007016:Hypophysectomy; D009347:Nelson Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D009378:Neoplasms, Multiple Primary; D010456:Peptides, Cyclic / Q000627:therapeutic use; D047748:Pituitary ACTH Hypersecretion / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D010899:Pituitary Apoplexy / Q000150:complications / Q000601:surgery; D010911:Pituitary Neoplasms / Q000150:complications / Q000601:surgery; D016634:Radiosurgery; D013004:Somatostatin / Q000031:analogs & derivatives / Q000627:therapeutic use; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D003998:Dicarboxylic Acids; D004873:Ergolines; D010456:Peptides, Cyclic; C060347:lanreotide; D013004:Somatostatin; C010038:azelaic acid; D000077465:Cabergoline; D013974:Thyroxine; D006854:Hydrocortisone