title: Magnetic resonance spectroscopy on hepatocellular carcinoma after transcatheter arterial chemoembolization.
abstract: OBJECTIVE
  Proton magnetic resonance spectroscopy (MRS) of the liver in vivo is in experimental phase. MRS observation on liver cancer after transcatheter arterial chemoembolization (TACE) has seldom been reported. This study was to investigate the value of MRS in assessing the metabolic changes of hepatocellular carcinoma (HCC) after TACE.
  
  
  METHODS
  Twenty-five consecutive patients with pathologically-confirmed HCC received 1H MRS of all hepatic lesions using 1.5T whole body MR scanner before TACE and at 3-10 days after TACE. Choline-to-lipid (Cho/Lip), glucogen/glucose-to-lipid (Glu/Lip), and glytamine/glutamate-to-lipid (Glx/Lip) ratios were measured and analyzed statistically.
  
  
  RESULTS
  The Cho/Lip, Glu/Lip, and Glx/Lip ratios were 0.21 +/- 0.08, 0.11 +/- 0.05, 0.28 +/- 0.10 before TACE, respectively, and were 0.10 +/- 0.08, 0.07 +/- 0.07, 0.18 +/- 0.12 after TACE, respectively, with significant differences (P < 0.05).
  
  
  CONCLUSIONS
  Using MRS can evaluate the early metabolic responses of HCC to TACE.
authors.affiliation: Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China. cjr.xiaoenhua@vip.163.com
authors.forename: Du-Jun
authors.initials: DJ
authors.lastname: Bian
authors.forename: En-Hua
authors.initials: EH
authors.lastname: Xiao
authors.forename: Dong-Xu
authors.initials: DX
authors.lastname: Hu
authors.forename: Xiang-Yu
authors.initials: XY
authors.lastname: Chen
authors.forename: Wei-Jun
authors.initials: WJ
authors.lastname: Situ
authors.forename: Shu-Wen
authors.initials: SW
authors.lastname: Yuan
authors.forename: Jian-Ling
authors.initials: JL
authors.lastname: Sun
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D002794:Choline / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000032:analysis; D008113:Liver Neoplasms / Q000378:metabolism / Q000628:therapy*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged
chemical_list: D008055:Lipids; D005973:Glutamine; D018698:Glutamic Acid; D006003:Glycogen; D005947:Glucose; D002794:Choline