RNA turnover in human mitochondria: more questions than answers?
Protein complexes responsible for RNA degradation play important role in three key aspects of RNA metabolism: they control stability of physiologically functional transcripts, remove the unnecessary RNA processing intermediates and destroy aberrantly formed RNAs. In mitochondria the post-transcriptional events seem to play a major role in regulation of gene expression, therefore RNA turnover is of particular importance. Despite many years of research, the details of this process are still a challenge. This review summarizes emerging landscape of interplay between the Suv3p helicase (SUPV3L1, Suv3), poly(A) polymerase and polynucleotide phosphorylase in controlling RNA degradation in human mitochondria.
Borowski
Lukasz S
LS
Institute of Genetics and Biotechnology, Faculty of Biology, Warsaw University, Pawinskiego 5a, 02-106 Warsaw, Poland.
Szczesny
Roman J
RJ
Brzezniak
Lien K
LK
Stepien
Piotr P
PP
D053487:DEAD-box RNA Helicases / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D011072:Poly U / Q000378:metabolism; D026723:Polyadenylation; D011062:Polynucleotide Adenylyltransferase / Q000378:metabolism; D011117:Polyribonucleotide Nucleotidyltransferase / Q000378:metabolism; D012313:RNA / Q000235:genetics / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability; D012331:RNA, Fungal / Q000235:genetics / Q000378:metabolism; D000077278:RNA, Mitochondrial; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism
D012331:RNA, Fungal; D000077278:RNA, Mitochondrial; D011072:Poly U; D012313:RNA; D011062:Polynucleotide Adenylyltransferase; D011117:Polyribonucleotide Nucleotidyltransferase; C469673:SUPV3L1 protein, human; D053487:DEAD-box RNA Helicases