[Evaluation of the usefulness cerebrospinal fluid myelin basic protein (MBP) concentration examination in patients with Lyme neuroborreliosis--preliminary study].
The aim of the study was evaluation of usefulness of cerebrospinal fluid (CSF) myelin basic protein (MBP) level examination in diagnostics of Lyme neuroborreliosis. The study was performed in 24 subjects. In all individuals CSF MBP concentration was estimated on the 1st day of hospitalization. In patients with depressive and cognitive impairments, proved in neuropsychological tests (group I), mean CSF MBP concentration was 3.1 ng/mL, whereas in subjects without abnormalities in tests (group II), respectively, 1.2 ng/mL. The difference of mean CSF MBP levels was statistically significant (p<0.01). The obtained results indicate usefulness of this CSF parameter, besides neuropsychological tests, in objective evaluation of clinical state in patients with chronic Lyme neuroborreliosis.
Kepa
Lucjan
L
Oddział Chorób Zakaźnych Slaskiego Uniwersytetu Medycznego w Bytomiu, przy Klinice Chorób Płuc i Gruźlicy Slaskiego Uniwersytetu Medycznego w Zabrzu.
D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000134:cerebrospinal fluid; D003072:Cognition Disorders / Q000134:cerebrospinal fluid* / Q000209:etiology; D003863:Depression / Q000134:cerebrospinal fluid* / Q000209:etiology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D020852:Lyme Neuroborreliosis / Q000134:cerebrospinal fluid* / Q000150:complications; D008297:Male; D008875:Middle Aged; D004676:Myelin Basic Protein / Q000134:cerebrospinal fluid*; D009483:Neuropsychological Tests; D011044:Poland; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D004676:Myelin Basic Protein