title: Resolution of secondary pulmonary alveolar proteinosis following treatment of rhinocerebral aspergillosis.
abstract: Pulmonary alveolar proteinosis can be secondary to inhaled dust exposure, malignancy, and chronic pulmonary infections. However, pulmonary alveolar proteinosis secondary to extrapulmonary aspergillosis has never been reported. We report herein a case of pulmonary alveolar proteinosis secondary to invasive rhinocerebral aspergillosis. Neither immune modulators nor whole lung lavage was applied during the treatment course. The severe respiratory distress subsided, hypoxia resolved, and radiological infiltrates improved following the successful treatment of invasive rhinocerebral aspergillosis alone.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 100, Taiwan.
authors.forename: Kun-Pei
authors.initials: KP
authors.lastname: Lin
authors.forename: Wang-Huei
authors.initials: WH
authors.lastname: Sheng
authors.forename: Cheng-Ping
authors.initials: CP
authors.lastname: Wang
authors.forename: Yih-Leong
authors.initials: YL
authors.lastname: Chang
authors.forename: Shang-Chwen
authors.initials: SC
authors.lastname: Chang
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D020953:Neuroaspergillosis / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D011649:Pulmonary Alveolar Proteinosis / Q000175:diagnosis / Q000209:etiology*; D011743:Pyrimidines / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; C068538:liposomal amphotericin B; D000666:Amphotericin B; D065819:Voriconazole