HMG modifications and nuclear function.
High mobility group (HMG) proteins assume important roles in regulating chromatin dynamics, transcriptional activities of genes and other cellular processes. Post-translational modifications of HMG proteins can alter their interactions with DNA and proteins, and consequently, affect their biological activities. Although the mechanisms through which these modifications are involved in regulating biological processes in different cellular contexts are not fully understood, new insights into these modification "codes" have emerged from the increasing appreciation of the functions of these proteins. In this review, we focus on the chemical modifications of mammalian HMG proteins and highlight their roles in nuclear functions.
Zhang
Qingchun
Q
Department of Chemistry, University of California, Riverside, CA 92521-0403, USA.
Wang
Yinsheng
Y
D000595:Amino Acid Sequence; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D024003:HMGA Proteins / Q000737:chemistry / Q000378:metabolism; D024002:HMGB Proteins / Q000737:chemistry / Q000378:metabolism; D024001:HMGN Proteins / Q000737:chemistry / Q000378:metabolism; D006609:High Mobility Group Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D011499:Protein Processing, Post-Translational
D024003:HMGA Proteins; D024002:HMGB Proteins; D024001:HMGN Proteins; D006609:High Mobility Group Proteins