title: A novel mesoporous biomaterial for treating dentin hypersensitivity.
abstract: An ideal material has yet to be discovered that can completely treat dentin hypersensitivity; however, calcium phosphate precipitation has exhibited potential value for the treatment of dentin hypersensitivity by the occlusion of dentinal tubules. We hypothesized that a novel mesoporous silica biomaterial (nano CaO@mesoporous silica, NCMS) containing nano-sized calcium oxide particles mixed with 30% phosphoric acid can efficiently occlude dentinal tubules and significantly reduce dentin permeability, even with the presence of pulpal pressure. This highly supersaturated Ca(2+)-and HPO(4)(2-)ion-containing NCMS paste was brushed onto dentin surfaces, and the ions diffused deeply into the dentinal tubules and formed a CaHPO(4).2H(2)O precipitation with a depth of 100 microm. The results of the dentin permeability tests showed that the novel mesoporous material exhibited a significant reduction in dentin permeability (p < 0.05), even under simulated pulpal pressure, as compared with our previously developed material, DP-bioglass, and a commercial desensitizing material, Seal & Protect.
authors.affiliation: School of Dentistry and Graduate Institute of Clinical Dentistry, National Taiwan University and National Taiwan University Hospital, No. 1, Chang-Te Street, Taipei 10016, Taiwan.
authors.forename: Y-C
authors.initials: YC
authors.lastname: Chiang
authors.forename: H-J
authors.initials: HJ
authors.lastname: Chen
authors.forename: H-C
authors.initials: HC
authors.lastname: Liu
authors.forename: S-H
authors.initials: SH
authors.lastname: Kang
authors.forename: B-S
authors.initials: BS
authors.lastname: Lee
authors.forename: F-H
authors.initials: FH
authors.lastname: Lin
authors.forename: H-P
authors.initials: HP
authors.lastname: Lin
authors.forename: C-P
authors.initials: CP
authors.lastname: Lin
mesh_terms: D000704:Analysis of Variance; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D017610:Calcium Compounds / Q000737:chemistry / Q000627:therapeutic use; D003804:Dentin / Q000187:drug effects* / Q000648:ultrastructure; D003807:Dentin Sensitivity / Q000188:drug therapy*; D004337:Drug Carriers / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D008422:Materials Testing; D053758:Nanoparticles / Q000627:therapeutic use* / Q000648:ultrastructure; D010087:Oxides / Q000737:chemistry / Q000627:therapeutic use; D019279:Resin Cements / Q000627:therapeutic use; D012212:Rheology; D012822:Silicon Dioxide / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D001672:Biocompatible Materials; D017610:Calcium Compounds; D004337:Drug Carriers; D010087:Oxides; D019279:Resin Cements; C442646:Seal and Protect resin cement; D012822:Silicon Dioxide; C016538:lime