title: Serum uric acid in top-level alpine skiers over four consecutive competitive seasons.
abstract: BACKGROUND
  Uric acid (UA), a major plasmatic antioxidant is an intracellular scavenger, especially during metabolic stress. UA serum concentration could be important for evaluating oxidant stress and the correspondent response in sportsmen, who are prone to the risk of oxidant increase and related cell and tissue damage.
  
  
  METHODS
  Blood was collected from 10 male and 8 female alpine skiers from the Italian National Team (current age range, 26-33 and 24-28 years, respectively) over an entire season. The analyses were performed using an uricase-based enzymatic method.
  
  
  RESULTS
  Mean UA values were 3.8 mg/dl in females and 4.8 mg/dl in males: a significant difference between genders was maintained across all four competitive seasons. No differences emerged within either gender during each season nor between different intra-seasonal or inter-seasonal blood drawings in individual athletes.
  
  
  CONCLUSIONS
  Our results suggest that serum UA in top-level athletes is a stable parameter. High-intensity workload caused serum UA changes lower than biological variability both within the competitive season or between different seasons. Serum UA increased immediately after exercise, but the resting concentration was not influenced by sports activity. The data of our study showed that this parameter is not useful for marking high physical demand or overtraining.
authors.affiliation: I.R.C.C.S. Istituto Ortopedico Galeazzi, Milano, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lombardi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Colombini
authors.forename: Cristian
authors.initials: C
authors.lastname: Ricci
authors.forename: Marco
authors.initials: M
authors.lastname: Freschi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lippi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Banfi
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D056352:Athletes; D015992:Body Mass Index; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D012621:Seasons; D012727:Sex Characteristics; D012865:Skiing; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D014527:Uric Acid