Epstein-Barr virus-associated uterine leiomyosarcoma in an adult lung transplant patient.
BACKGROUND
Multiple viruses have been associated with carcinogenesis in solid-organ transplant patients. Although Epstein-Barr virus (EBV) has been associated with lymphomas in immunocompromised patients, an association with smooth muscle tumors recently has been described.


METHODS
An EBV immunoglobulin G-positive woman underwent bilateral lung transplant for sarcoidosis. She was placed on immunosuppression and prophylaxis for opportunistic infections. She presented 5 months later with an EBV-positive uterine leiomyosarcoma. Postoperative therapy included a decrease in immunosuppression and antiviral therapy. Recurrence was noted after 1 year; the patient developed sepsis while undergoing chemotherapy and declined further therapy.


CONCLUSIONS
Epstein-Barr virus-associated leiomyosarcoma can occur in the uterus in immunosuppressed patients.
Sunde
Jan
J
From the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, Washington; the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington Hospital Medical Center, Washington, DC and; the Advanced Lung Disease and Transplant Center, Inova Fairfax Hospital, Falls Church, Virginia.
Chetty-John
Shilpa
S
Shlobin
Oksana A
OA
Boice
Charles R
CR
D000328:Adult; D017809:Fatal Outcome; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D007890:Leiomyosarcoma / Q000276:immunology / Q000473:pathology / Q000821:virology*; D016040:Lung Transplantation / Q000276:immunology*; D009364:Neoplasm Recurrence, Local / Q000821:virology*; D014594:Uterine Neoplasms / Q000276:immunology / Q000473:pathology / Q000821:virology*