Stilbene analogs as inducers of apolipoprotein-I transcription.
Based on the naturally occurring stilbene, Resveratrol, a series of novel stilbene derivatives were synthesized, which have the ability to induce the expression of the ApoA-I gene. Several compounds equally or more potent than Resveratrol were identified. trans-4,4'-dihydroxy-2-methoxystilbene was the most potent (4.6x more potent than Resveratrol). These compounds provide an early lead into new drugs to treat atherosclerosis.
Hansen
Henrik C
HC
Resverlogix Corp., Suite 202, 279 Midpark Way SE, Calgary, Alberta, T2X 1M2, Canada. henrik@resverlogix.com
Chiacchia
Fabrizio S
FS
Patel
Reena
R
Wong
Norman C W
NC
Khlebnikov
Vladimir
V
Jankowska
Renata
R
Patel
Kalpesh
K
Reddy
M Madhava
MM
D016632:Apolipoprotein A-I / Q000235:genetics*; D018938:Caco-2 Cells; D006801:Humans; D015394:Molecular Structure; D011401:Promoter Regions, Genetic / Q000187:drug effects / Q000235:genetics; D013237:Stereoisomerism; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects* / Q000235:genetics; D015854:Up-Regulation / Q000187:drug effects* / Q000235:genetics
D016632:Apolipoprotein A-I; D013267:Stilbenes