title: Extensive mammalian ancestry of pandemic (H1N1) 2009 virus.
abstract: We demonstrate that the novel pandemic influenza (H1N1) viruses have human virus-like receptor specificity and can no longer replicate in aquatic waterfowl, their historic natural reservoir. The biological properties of these viruses are consistent with those of their phylogenetic progenitors, indicating longstanding adaptation to mammals.
authors.affiliation: Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee 38105-3678, USA.
authors.forename: Natalia A
authors.initials: NA
authors.lastname: Ilyushina
authors.forename: Jeong Ki
authors.initials: JK
authors.lastname: Kim
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Negovetich
authors.forename: Young Ki
authors.initials: YK
authors.lastname: Choi
authors.forename: Victoria
authors.initials: V
authors.lastname: Lang
authors.forename: Nicolai V
authors.initials: NV
authors.lastname: Bovin
authors.forename: Heather L
authors.initials: HL
authors.lastname: Forrest
authors.forename: Min Suk
authors.initials: MS
authors.lastname: Song
authors.forename: Philippe Noriel Q
authors.initials: PN
authors.lastname: Pascua
authors.forename: Chul Joong
authors.initials: CJ
authors.lastname: Kim
authors.forename: Robert G
authors.initials: RG
authors.lastname: Webster
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Webby
mesh_terms: D000818:Animals; D004196:Disease Outbreaks; D004197:Disease Reservoirs / Q000821:virology*; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics* / Q000502:physiology; D008322:Mammals / Q000821:virology*; D010802:Phylogeny; D011784:Quail / Q000821:virology; D013552:Swine; D013553:Swine Diseases / Q000821:virology*; D014779:Virus Replication / Q000235:genetics*
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus