Capecitabine cardiac toxicity presenting as effort angina: a case report.
We report a case of capecitabine-induced cardiotoxicity (effort angina) in a woman with metastatic breast carcinoma. Due to cancer progression, rechallenge of therapy with capecitabine was attempted, using several strategies in order to prevent cardiotoxicity. The most (even if not fully) effective strategy was reducing capecitabine dosage together with nitrates, calcium-channel blockers and trimetazidine therapy.
Lestuzzi
Chiara
C
Cardiologia, Centro di Riferimento Oncologico, IRCCS, via F. Gallini 2, 33081 Aviano, Pordenone, Italy. clestuzzi@cro.it
Crivellari
Diana
D
Rigo
Fausto
F
Viel
Elda
E
Meneguzzo
Nereo
N
D000787:Angina Pectoris / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D000069287:Capecitabine; D002317:Cardiovascular Agents / Q000627:therapeutic use; D003329:Coronary Vasospasm / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D018618:Echocardiography, Doppler, Color; D018619:Echocardiography, Doppler, Pulsed; D004562:Electrocardiography; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008875:Middle Aged
D000964:Antimetabolites, Antineoplastic; D002317:Cardiovascular Agents; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil