title: Mucosal immunity modulated by integrative meditation in a dose-dependent fashion.
abstract: OBJECTIVE
  Prior research had shown that an additional training session immediately after acute stress increased release of salivary secretory immunoglobin A (sIgA) in a group trained with 5-day Integrative Body-Mind Training (IBMT) in comparison to a control group given the same amount of relaxation training. However, 5 days of training did not influence the basal secretion of sIgA. The current study seeks to extend this finding and determine whether increasing amounts of IBMT will increase the basal sIgA level, suggesting further improvements in mucosal immune function.
  
  
  METHODS
  Thirty-five (35) Chinese undergraduates were randomly assigned either to an experimental group receiving 4 weeks of IBMT or a relaxation control. Salivary sIgA levels at baseline before training and three stages (i.e., rest, stress, and additional 20-minute practice) after 2 and 4 weeks training were assessed.
  
  
  RESULTS
  The basal sIgA levels increased significantly in the experimental subjects but not in controls after 4 weeks of training. An additional IBMT practice session immediately after acute stress produced significantly higher sIgA release for the IBMT-trained group in comparison with controls at week 2 and 4. This effect was larger at week 4 than week 2.
  
  
  CONCLUSIONS
  These results indicate that the IBMT produces a change in the basal immune system and larger acute effects as the dose of training increases.
authors.affiliation: Institute of Neuroinformatics and Laboratory for Body and Mind, Dalian University of Technology, Dalian, China.
authors.forename: Yaxin
authors.initials: Y
authors.lastname: Fan
authors.forename: Yi-Yuan
authors.initials: YY
authors.lastname: Tang
authors.forename: Yinghua
authors.initials: Y
authors.lastname: Ma
authors.forename: Michael I
authors.initials: MI
authors.lastname: Posner
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D018928:Immunity, Mucosal / Q000502:physiology*; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D008297:Male; D019122:Meditation; D012064:Relaxation Therapy; D012463:Saliva / Q000276:immunology; D013315:Stress, Psychological / Q000276:immunology* / Q000628:therapy; D055815:Young Adult
chemical_list: D007071:Immunoglobulin A, Secretory