title: Cost-effectiveness of pentostatin compared with cladribine in the management of hairy cell leukemia in the United Kingdom.
abstract: OBJECTIVE
  This article assesses the cost-effectiveness of pentostatin compared with cladribine in the management of hairy cell leukemia (HCL) in the United Kingdom.
  
  
  METHODS
  A systematic literature search for papers on HCL was performed using MEDLINE, EMBASE, Current Contents, NHS Economic Evaluation Database, and the Cochrane computerized database. Search terms were HCL plus 1 of the following: incidence, prevalence, epidemiology, cladribine, interferon, pentostatin, rituximab, splenectomy, utility, quality of life, cost-effectiveness, cost-utility, resource utilization, economic, or cost. Published clinical outcomes and estimates of health care resource use obtained from 10 consultant hematologists across the United Kingdom were used to construct a 5-year Markov model depicting the current management of HCL in the United Kingdom. Utilities for health states in the model were obtained from the general public using standard gamble, time tradeoff, and visual analog scale techniques. The model was used to consider the decision by a clinician to initially treat an HCL patient with either pentostatin or cladribine and to estimate the relative cost-effectiveness of pentostatin over 5 years (at 2007/2008 prices) from the perspective of the UK's National Health Service (NHS).
  
  
  RESULTS
  According to the model, 64% of all pentostatin-treated patients are expected to be in relapse-free remission at 5 years compared with 49% of cladribine-treated patients (P = 0.04). Repeat treatment of initial partial responders, nonresponders, and those who relapse during the 5 years is expected to result in complete remission in 92% of pentostatintreated patients and 90% of cladribine-treated patients at 5 years. Using pentostatin instead of cladribine is expected to lead to a minimal cost increase (from 21,325 pounds to 21,609 pounds) and an improvement in health status (from 3.64 to 3.77 quality-adjusted life-years [QALYs]) over 5 years. Hence, the cost per QALY gained from using pentostatin is expected to be 5000 pounds. Moreover, pentostatin has a 0.90 probability of being cost-effective for a threshold of 20,000 pounds per QALY. Accordingly, using pentostatin as a first-line treatment for patients with HCL is an effective use of NHS resources.
  
  
  CONCLUSIONS
  Based on current practice, this model predicts that pentostatin is a cost-effective treatment compared with cladribine in the management of HCL from the perspective of the UK's NHS.
authors.affiliation: Catalyst Health Economics Consultants, Northwood, Middlesex, United Kingdom; Postgraduate Medical School, University of Surrey, Guildford, Surrey, United Kingdom. julian.guest@catalyst-health.co.uk
authors.forename: Julian F
authors.initials: JF
authors.lastname: Guest
authors.forename: Helen
authors.initials: H
authors.lastname: Smith
authors.forename: Erikas
authors.initials: E
authors.lastname: Sladkevicius
authors.forename: Graham
authors.initials: G
authors.lastname: Jackson
mesh_terms: D000970:Antineoplastic Agents / Q000191:economics* / Q000627:therapeutic use; D017338:Cladribine / Q000191:economics* / Q000627:therapeutic use; D003362:Cost-Benefit Analysis; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000188:drug therapy / Q000191:economics*; D018803:Models, Economic; D015649:Pentostatin / Q000191:economics* / Q000627:therapeutic use; D019057:Quality-Adjusted Life Years; D016896:Treatment Outcome; D006113:United Kingdom
chemical_list: D000970:Antineoplastic Agents; D015649:Pentostatin; D017338:Cladribine