Surgical resection for pulmonary metastasis from hepatocellular carcinoma: analysis of prognosis in relation to primary control.
BACKGROUND
Advances in local treatments for hepatocellular carcinoma (HCC) have seen better prognosis. There were few studies on surgery for pulmonary metastasis from HCC controlled by local treatment. This study was conducted to analyze prognostic factors after surgery for pulmonary metastasis from HCC.


METHODS
We reviewed 32 patients who underwent surgery for pulmonary metastasis from HCC and analyzed prognostic factors.


RESULTS
HCC was controlled by surgery in 16 patients and by local treatment in 16 patients at the time of pulmonary resection. The median survival time after pulmonary resection was significantly better for HCC controlled by surgery, disease-free time >or=12 months, TMN stage I-II, and T factor 1-2 of primary HCC. The median survival time was better for lesion <or=2 and Child-Pugh score A, but they were not significant (P = 0.053, 0.069). In multivariate analysis, HCC controlled by surgical treatment (P = 0.008), and lesion <or=2 (P = 0.030) were independent prognostic factors.


CONCLUSIONS
Our Results indicated that surgical resection for pulmonary metastasis from HCC might be beneficial for patients whose HCC was controlled by surgery and the number of lesions was lower than 3.
Lee
Chang Young
CY
Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, South Korea.
Bae
Mi Kyung
MK
Park
In Kyu
IK
Kim
Dae Joon
DJ
Lee
Jin Gu
JG
Choi
Jin Sub
JS
Han
Kwang-Hyub
KH
Chung
Kyung Young
KY
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology*; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D011379:Prognosis