title: Iridium-monodentate phosphoramidite-catalyzed asymmetric hydrogenation of substituted benzophenone N-H imines.
abstract: Homogeneous asymmetric hydrogenation of unprotected benzophenone N-H imines 1a-r using Ir-(S)-N-benzyl-N-methyl-MonoPhos as a catalyst provides chiral amines 2a-r in 80-96% yield with enantioselectivities up to 98% ee (18 examples) for ortho-substituted substrates.
authors.affiliation: Department of Chemistry, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854-8066, USA.
authors.forename: Guohua
authors.initials: G
authors.lastname: Hou
authors.forename: Ran
authors.initials: R
authors.lastname: Tao
authors.forename: Yongkui
authors.initials: Y
authors.lastname: Sun
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
authors.forename: Francis
authors.initials: F
authors.lastname: Gosselin
mesh_terms: D000588:Amines / Q000138:chemical synthesis*; D001577:Benzophenones / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D007097:Imines / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry; D008024:Ligands; D009942:Organometallic Compounds / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D001577:Benzophenones; D007097:Imines; D008024:Ligands; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; C434331:phosphoramidite; D007495:Iridium