title: Rare casbane diterpenoids from the Hainan soft coral Sinularia depressa.
abstract: A series of nine casbane diterpenes, compounds 5-13, exhibiting either cis or trans ring junctions were isolated from the Hainan soft coral Sinularia depressa. The structures of this group of compounds, the basic member of which was named depressin (5), were established by detailed spectroscopic analysis. In addition, the absolute configuration of the main metabolite, 10-hydroxydepressin (7), and of its epimer, 1-epi-10-hydroxydepressin (8), was determined by a combination of conformational analysis and the modified Mosher's method. A stereochemical relationship between all isolated molecules was investigated by analyzing their circular dichroism profiles. Antiproliferative and antibacterial activities of the depressins were also evaluated.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Marianna
authors.initials: M
authors.lastname: Carbone
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Vitale
authors.forename: Pietro
authors.initials: P
authors.lastname: Amodeo
authors.forename: Francesco
authors.initials: F
authors.lastname: Castelluccio
authors.forename: Giovanna
authors.initials: G
authors.lastname: Sicilia
authors.forename: Ernesto
authors.initials: E
authors.lastname: Mollo
authors.forename: Michela
authors.initials: M
authors.lastname: Nappo
authors.forename: Guido
authors.initials: G
authors.lastname: Cimino
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
authors.forename: Margherita
authors.initials: M
authors.lastname: Gavagnin
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: C548107:10-hydroxydepressin; D000970:Antineoplastic Agents; D004224:Diterpenes