[Correlation of the expression of survivin and caspase-3 proteins in juvenile laryngeal papilloma].
OBJECTIVE
To investigate correlation between the expression of survivin and caspase-3 proteins in juvenile laryngeal papilloma.


METHODS
The expression of survivin and caspase-3 proteins were detected with immunohistochemical method in 43 cases of juvenile laryngeal papilloma, 25 vocal nodules and 25 normal laryngeal mucosa.


RESULTS
The positive rates of survivin protein in juvenile laryngeal papilloma were 57.14% and higher than that in vocal nodules (P<0.01) and the normal laryngeal mucosa (P<0.01). And the Caspase-3 protein positive rate was 26.19% in juvenile laryngeal papilloma and lower than that in vocal nodules and the normal laryngeal mucosa (P<0.01). There was a significant negative correlation between the expression of survivin and caspase-3 in juvenile laryngeal papilloma.


CONCLUSIONS
The abnormal expression of survivin and caspase-3 may play important role in the pathogenesis of juvenile laryngeal papilloma.
Wang
Wu
W
Children's Hospital, Chongqing Medical University, Chongqing, China.
Zhou
Yuan-da
YD
He
Hai-xia
HX
D053148:Caspase 3 / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007223:Infant; D051034:Inhibitor of Apoptosis Proteins; D007822:Laryngeal Neoplasms / Q000235:genetics*; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D010212:Papilloma / Q000235:genetics*; D000077022:Survivin
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D000077022:Survivin; D053148:Caspase 3