title: [Lobular intra-epithelial neoplasia: atypical lobular hyperplasia and lobular carcinoma in situ].
abstract: OBJECTIVE
  To review main knowledge about lobular intra-epithelial neoplasia with special interest for daily practice management.
  
  
  RESULTS
  Intra-epithelial lobular neoplasias (ILN) are non invasive proliferations within the terminal ducto-lobular unit of monomorphic loosely cohesive small cells. A lack of expression of the E-cadherin adhesion molecule is often observed as in invasive lobular breast cancer. ILN are infrequent, however, a rise in incidence partly, due to the generalization of mammographic screening, is observed. Actually ILN are usually asymptomatic and diagnosed after breast biopsy for unspecified microcalcifications. ILN are associated with an increased risk of breast cancer that persists over 20 years after the initial diagnosis. The average risk is 4.2 % for the ipsilateral breast and 3,5 % for the controlateral breast. However, a great variability in the risk estimation is observed between the studies. There is no consensus on how to treat ILN. Surgical options have varied from biopsy to bilateral mastectomy. Current tendency is favouring lumpectomy.
authors.affiliation: Service de gynécologie-obstétrique, hôpital Saint-Antoine, Assistance publique-Hôpitaux de Paris, université Pierre-et-Marie-Curie-Paris VI, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France. yan.ansquer@sat.aphp.fr
authors.forename: Y
authors.initials: Y
authors.lastname: Ansquer
authors.forename: P
authors.initials: P
authors.lastname: Santulli
authors.forename: C
authors.initials: C
authors.lastname: Colas
authors.forename: M
authors.initials: M
authors.lastname: Jamali
authors.forename: C
authors.initials: C
authors.lastname: Tournigand
authors.forename: L
authors.initials: L
authors.lastname: Duperray
authors.forename: B
authors.initials: B
authors.lastname: Duperray
authors.forename: D
authors.initials: D
authors.lastname: Jannet
authors.forename: B
authors.initials: B
authors.lastname: Carbonne
mesh_terms: D001706:Biopsy; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D015820:Cadherins / Q000032:analysis; D002114:Calcinosis; D018275:Carcinoma, Lobular / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D020847:Estrogen Receptor Modulators / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008327:Mammography; D008408:Mastectomy; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012307:Risk Factors
chemical_list: D015820:Cadherins; D020847:Estrogen Receptor Modulators