Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma.
The synthesis and in vitro activity of R(+)-Limonene derivatives against Leishmania and Trypanosoma cruzi strains are reported. Seven compounds have shown better in vitro activity against Leishmania (V.)braziliensis than the standard drug pentamidine. Additionally, we have identified two promising new anti-T. cruzi limonene derivatives.
Graebin
Cedric S
CS
Lab. de Síntese Orgânica Medicinal (LaSOM), Faculdade de Farmácia, UFRGS, Avenida Ipiranga, 2752, sala 705, 90610-000 Porto Alegre, RS, Brazil.
Madeira
Maria de F
Mde F
Yokoyama-Yasunaka
Jenicer K U
JK
Miguel
Danilo C
DC
Uliana
Silvia R B
SR
Benitez
Diego
D
Cerecetto
Hugo
H
González
Mercedes
M
Rosa
Ricardo Gomes da
RG
Eifler-Lima
Vera Lucia
VL
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D053138:Cyclohexenes / Q000494:pharmacology*; D066298:In Vitro Techniques; D007891:Leishmania / Q000187:drug effects*; D000077222:Limonene; D008253:Macaca mulatta; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013729:Terpenes / Q000494:pharmacology*; D014345:Trypanosoma / Q000187:drug effects*
D000981:Antiprotozoal Agents; D053138:Cyclohexenes; D013729:Terpenes; D000077222:Limonene