Relationship of serum progesterone (P) level the day after human chorionic gonadotropin (hCG) injection on outcome following in vitro fertilization-embryo transfer (IVF-ET).
OBJECTIVE
To determine if either too little or too much of a rise in serum progesterone (P) on the day after human chorionic gonadotropin (hCG) injection has any negative impact on pregnancy outcome following in vitro fertilization-embryo transfer (IVF-ET).


METHODS
Retrospective review. Three progesterone groups established--low, normal and high.


RESULTS
There was a significantly higher clinical pregnancy rate in the normal P group vs low or high. There were no significant differences in ongoing delivered pregnancy rates but a trend for higher implantation rates in the normal P group.


CONCLUSIONS
These data are consistent with the hypothesis that either too little or too much P can adversely effect implantation. However, the differences are not of sufficient magnitude to warrant a clinical intervention, e.g., deferring fresh transfer and freezing the embryos for future transfer.
Check
J H
JH
The University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA. laurie@ccivf.com
Amui
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J
Choe
J K
JK
Brasile
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D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D005307:Fertilization in Vitro; D006801:Humans; D007273:Injections, Intramuscular; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000097:blood*
D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D011374:Progesterone