title: Antimicrobial nucleoside antibiotics targeting cell wall assembly: recent advances in structure-function studies and nucleoside biosynthesis.
abstract: The quest for new antibiotics, especially those with activity against Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in the last 40 years, with this limited number falling into only four new structural classes. Several nucleoside natural product antibiotics target bacterial translocase MraY, involved in the lipid-linked cycle of peptidoglycan biosynthesis, and fungal chitin synthase. Biosynthetic studies on the nikkomycin, caprazamycin and pacidamycin/mureidomycin families are also reviewed.
authors.affiliation: School of Chemistry, University of East Anglia, Norwich, NR4 7TJ, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Winn
authors.forename: Rebecca J M
authors.initials: RJ
authors.lastname: Goss
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Kimura
authors.forename: Timothy D H
authors.initials: TD
authors.lastname: Bugg
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism*; D015394:Molecular Structure; D009705:Nucleosides / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D009705:Nucleosides