Effect of formulation parameters on the preparation of superporous hydrogel self-nanoemulsifying drug delivery system (SNEDDS) of carvedilol.
The purpose of this study was to formulate a superporous hydrogel (SPH) containing carvedilol self-nanoemulsifying drug delivery system. Effects of formulation parameters (amount of SPH and 0.1 N HCl used during drug loading) were studied in 3(2) factorial design. Response surface plots showed significant effect of the parameters on hydrogel swelling, carvedilol content, and carvedilol in vitro release. Regression equations were generated to calculate the desirable responses.
Mahmoud
Enas Ahmed
EA
Faculty of Pharmacy, Cairo University, Cairo, Egypt. enasamahmoud@gmail.com
Bendas
Ehab R
ER
Mohamed
Magdy I
MI
D002227:Carbazoles; D000077261:Carvedilol; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D016503:Drug Delivery Systems / Q000379:methods*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D011412:Propanolamines
D002227:Carbazoles; D004304:Dosage Forms; D011412:Propanolamines; D000077261:Carvedilol; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate