title: Effect of formulation parameters on the preparation of superporous hydrogel self-nanoemulsifying drug delivery system (SNEDDS) of carvedilol.
abstract: The purpose of this study was to formulate a superporous hydrogel (SPH) containing carvedilol self-nanoemulsifying drug delivery system. Effects of formulation parameters (amount of SPH and 0.1 N HCl used during drug loading) were studied in 3(2) factorial design. Response surface plots showed significant effect of the parameters on hydrogel swelling, carvedilol content, and carvedilol in vitro release. Regression equations were generated to calculate the desirable responses.
authors.affiliation: Faculty of Pharmacy, Cairo University, Cairo, Egypt. enasamahmoud@gmail.com
authors.forename: Enas Ahmed
authors.initials: EA
authors.lastname: Mahmoud
authors.forename: Ehab R
authors.initials: ER
authors.lastname: Bendas
authors.forename: Magdy I
authors.initials: MI
authors.lastname: Mohamed
mesh_terms: D002227:Carbazoles; D000077261:Carvedilol; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D016503:Drug Delivery Systems / Q000379:methods*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D011412:Propanolamines
chemical_list: D002227:Carbazoles; D004304:Dosage Forms; D011412:Propanolamines; D000077261:Carvedilol; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate