An orphan nuclear receptor finds a home.
In this issue of Molecular Cell, Lee et al. (2010) show that the retinoic acid receptor-related orphan receptor alpha (RORalpha) can suppress the Wnt/beta-catenin signaling pathway in a Wnt5a- and PKC-dependent manner that does not alter beta-catenin stabilization or the recruitment of beta-catenin to Wnt target promoters.
Kimmel
Alan R
AR
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-8028, USA. ark1@helix.nih.gov
D006801:Humans; D008954:Models, Biological; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1 / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D057050:Receptor Tyrosine Kinase-like Orphan Receptors / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism / Q000502:physiology; D051176:beta Catenin / Q000378:metabolism
D057094:Nuclear Receptor Subfamily 1, Group F, Member 1; C539738:RORA protein, human; D051153:Wnt Proteins; D051176:beta Catenin; C078717:ROR2 protein, human; D057050:Receptor Tyrosine Kinase-like Orphan Receptors