Photoacoustic ocular imaging.
We developed a photoacoustic ocular imaging device and demonstrated its utility in imaging the deeper layers of the eye including the retina, choroid, and optic nerve. Using safe laser intensity, the photoacoustic system was able to visualize the blood distribution of an enucleated pig's eye and an eye of a living rabbit. Ultrasound images, which were simultaneously acquired, were overlaid on the photoacoustic images to visualize the eye's anatomy. Such a system may be used in the future for early detection and improved management of neovascular ocular diseases, including wet age-related macular degeneration and proliferative diabetic retinopathy.
de la Zerda
Adam
A
Molecular Imaging Program at Stanford, the Bio-X Program and the Department of Radiology,Stanford University, Palo Alto, California 94305, USA.
Paulus
Yannis M
YM
Teed
Robert
R
Bodapati
Sunil
S
Dollberg
Yosh
Y
Khuri-Yakub
Butrus T
BT
Blumenkranz
Mark S
MS
Moshfeghi
Darius M
DM
Gambhir
Sanjiv Sam
SS
D000162:Acoustics; D000818:Animals; D049109:Cell Proliferation; D002829:Choroid / Q000473:pathology*; D003930:Diabetic Retinopathy / Q000473:pathology; D003952:Diagnostic Imaging / Q000379:methods; D004867:Equipment Design; D005123:Eye / Q000473:pathology*; D005260:Female; D009900:Optic Nerve / Q000473:pathology*; D055095:Optics and Photonics; D011817:Rabbits; D012160:Retina / Q000473:pathology*; D013552:Swine; D013696:Temperature