Formulation and evaluation of a proniosome hydrocortisone gel in comparison with a commercial cream.
Proniosomes, a novel drug delivery approach for increasing permeation of hydrocortisone through the skin, were investigated. Proniosome hydrocortisone gel was prepared by a coacervation-phase separation method using different combinations of non-ionic surfactants with cholesterol and lecithin. Proniosome formulations were characterized for vesicle size, entrapment efficiency, and drug content uniformity. Span 20:Span 40, Span 20:Span 60 and Span 20:Span 80 combinations showed good entrapment compared with Span: Tween combinations (Span 20:Tween 40, Span 20:Tween 60, Span 20:Tween 80). In vitro release in 8h from a Span 20:Span 80 proniosome 1% hydrocortisone formulation was high (58.29 %) compared to the other proniosome formulations. Proniosome hydrocortisone gel shows diffusion type release which was confirmed by Higuchi and Peppas plot. In vivo studies in mice confirmed that the proniosome 1% hydrocortisone formulation was more active than a commercially marketed 1% hydrocortisone cream. Topical application of hydrocortisone in the form of proniosomes leads to prolonged action.
Sankar
V
V
Department of Pharmaceutics, P.S.G College of Pharmacy and Hospitals, Peelamedu, Coimbatore, India. sansunv@yahoo.co.in
Praveen
C
C
Prasanth
K G
KG
Srinivas
C R
CR
Ruckmann
K
K
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D015194:Diffusion Chambers, Culture; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D005782:Gels; D006854:Hydrocortisone / Q000008:administration & dosage* / Q000737:chemistry; D051379:Mice; D053758:Nanoparticles; D009824:Ointments; D010316:Particle Size; D051381:Rats; D012869:Skin Absorption; D013056:Spectrophotometry, Ultraviolet; D013501:Surface-Active Agents
D000893:Anti-Inflammatory Agents; D005782:Gels; D009824:Ointments; D013501:Surface-Active Agents; D006854:Hydrocortisone