title: The severity of autism is associated with toxic metal body burden and red blood cell glutathione levels.
abstract: This study investigated the relationship of children's autism symptoms with their toxic metal body burden and red blood cell (RBC) glutathione levels. In children ages 3-8 years, the severity of autism was assessed using four tools: ADOS, PDD-BI, ATEC, and SAS. Toxic metal body burden was assessed by measuring urinary excretion of toxic metals, both before and after oral dimercaptosuccinic acid (DMSA). Multiple positive correlations were found between the severity of autism and the urinary excretion of toxic metals. Variations in the severity of autism measurements could be explained, in part, by regression analyses of urinary excretion of toxic metals before and after DMSA and the level of RBC glutathione (adjusted R(2) of 0.22-0.45, P < .005 in all cases). This study demonstrates a significant positive association between the severity of autism and the relative body burden of toxic metals.
authors.affiliation: Division of Basic Medical Sciences, Southwest College of Naturopathic Medicine, Tempe, AZ 85282, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Adams
authors.forename: M
authors.initials: M
authors.lastname: Baral
authors.forename: E
authors.initials: E
authors.lastname: Geis
authors.forename: J
authors.initials: J
authors.lastname: Mitchell
authors.forename: J
authors.initials: J
authors.lastname: Ingram
authors.forename: A
authors.initials: A
authors.lastname: Hensley
authors.forename: I
authors.initials: I
authors.lastname: Zappia
authors.forename: S
authors.initials: S
authors.lastname: Newmark
authors.forename: E
authors.initials: E
authors.lastname: Gehn
authors.forename: R A
authors.initials: RA
authors.lastname: Rubin
authors.forename: K
authors.initials: K
authors.lastname: Mitchell
authors.forename: J
authors.initials: J
authors.lastname: Bradstreet
authors.forename: J M
authors.initials: JM
authors.lastname: El-Dahr