[Differences of clinical manifestations from cytomegalovirus infection in children of various age groups].
OBJECTIVE
Newborns have been the focus group for most studies of cytomegalovirus infection. The objective of the study is to share some preliminary analysis on clinical manifestation differences resulting from cytomegalovirus infection in children of various age groups.


METHODS
The clinical data of 108 children with cytomegalovirus infection were retrospectively reviewed. The children were classified into three age groups: <6 months, 6-12 months and >12 months. The differences in clinical manifestations from cytomegalovirus infection among the three age groups were identified.


RESULTS
Each age group carried distinctive differences in the occurrence of hepatic damage, jaundice, pneumonia, and hematological manifestations, as well as incidence rate of malformation (p<0.05 or 0.01). The primary clinical manifestations of group<6 months old were hepatic damage(83%), pneumonia(47%) and jaundice (43%). There was a similar proportion of anicteric-hepatitis and icteric-hepatitis; however a low incidence rate of hematological disease (6%) was found in group<6 months old. The primary clinical manifestations of group 6-12 months old were hepatic damage (86%), mostly with no presence of jaundice, pneumonia (33%), and hematological disease (20%). Hepatic damage (52%) and hematological disease (33%) were leading clinical symptoms in group>12 months old where jaundice and pneumonia were rare events.


CONCLUSIONS
End-organ damage triggered by cytomegalovirus infection is related to the age of the affected children closely.
Xiao
Yong-Mei
YM
Department of Digestion, Shanghai Children's Hospital Affiliated to Jiaotong University, Shanghai 200040, China.
Hu
Zhi-Hong
ZH
D000367:Age Factors; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000628:therapy; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male