title: Development of a compensation algorithm for accurate depth localization in diffuse optical tomography.
abstract: Diffuse optical tomography endures poor depth localization, since its sensitivity decreases severely with increased depth. In this study, we demonstrate a depth compensation algorithm (DCA), which optimally counterbalances the decay nature of light propagation in tissue so as to accurately localize absorbers in deep tissue. The novelty of DCA is to directly modify the sensitivity matrix, rather than the penalty term of regularization. DCA is based on maximum singular values (MSVs) of layered measurement sensitivities; these MSVs are inversely utilized to create a balancing weight matrix for compensating the measurement sensitivity in increased depth. Both computer simulations and laboratory experiments were performed to validate DCA. These results demonstrate that one (or two) 3-cm-deep absorber(s) can be accurately located in both lateral plane and depth within the laboratorial position errors.
authors.affiliation: Department of Bioengineering, Joint Graduate Program between University of Texas at Arlington and University of Texas Southwestern Medical Center, University of Texas at Arlington, Arlington, Texas 76019, USA
authors.forename: Haijing
authors.initials: H
authors.lastname: Niu
authors.forename: Fenghua
authors.initials: F
authors.lastname: Tian
authors.forename: Zi-Jing
authors.initials: ZJ
authors.lastname: Lin
authors.forename: Hanli
authors.initials: H
authors.lastname: Liu
mesh_terms: D000465:Algorithms; D001921:Brain / Q000473:pathology*; D003198:Computer Simulation; D003952:Diagnostic Imaging / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008027:Light; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D041622:Tomography, Optical / Q000379:methods*