title: Effect of multisyringe hyaluronic acid facial rejuvenation on perceived age.
abstract: BACKGROUND
  The objective of aesthetic treatments is to create a more youthful appearance. Most injectable fillers are indicated for the reduction of nasolabial folds, but the current aesthetic movement is toward volume replacement in multiple areas, known as global fillers or liquid face-lift.
  
  
  OBJECTIVE
  To quantify the degree of perceived age reduction from multisyringe hyaluronic acid treatment.
  
  
  METHODS
  Ten women were treated with 6 to 8 mL of hyaluronic acid. Exclusion criteria were no laser for 6 months and no hyaluronic acid fillers for 6 months or semipermanent fillers for 1 year. High-resolution photographs were taken in identical lighting and position before and 2 and 4 weeks after treatment. Three blinded dermatologists rated patients' ages before and after from photographs.
  
  
  RESULTS
  The dermatologists reported an average of 6.1 to 7.3 years of reduction in apparent age at 2 and 4 weeks, respectively. The patients perceived a decrease in apparent age of 7.8 and 9 years.
  
  
  CONCLUSIONS
  Multisyringe injection of hyaluronic acid filler into the aging face results in a reduction of apparent age from 6.1 to 9 years after 2 to 4 weeks. Full-face correction with hyaluronic acid is an important procedure in the armamentarium of anti-aging techniques.
authors.affiliation: Advanced Dermatology, SKINQRI, LLC, Skinfo, LLC, Lincolnshire, Illinois 60069, USA. drtaub@advdermatology.com
authors.forename: Amy Forman
authors.initials: AF
authors.lastname: Taub
authors.forename: Deborah
authors.initials: D
authors.lastname: Sarnoff
authors.forename: Michael
authors.initials: M
authors.lastname: Gold
authors.forename: Carolyn
authors.initials: C
authors.lastname: Jacob
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000328:Adult; D003357:Cosmetic Techniques; D016503:Drug Delivery Systems; D005145:Face / Q000601:surgery; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007267:Injections; D019344:Lactic Acid / Q000008:administration & dosage; D008875:Middle Aged; D011091:Polyesters; D011108:Polymers / Q000008:administration & dosage; D011446:Prospective Studies; D012060:Rejuvenation; D015595:Skin Aging / Q000187:drug effects
chemical_list: D000276:Adjuvants, Immunologic; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D006820:Hyaluronic Acid