Increased fat due to estrogen deficiency induces bone loss by elevating monocyte chemoattractant protein-1 (MCP-1) production.
Ovariectomy (OVX)-induced estrogen withdrawal resulted in both bone loss and an increase in fat. We observed elevated osteoclast (OC) formation by bone marrow-derived macrophages treated with medium conditioned by fats from OVX mice, but not from sham-operated mice. Fats from OVX mice expressed and secreted higher levels of monocyte chemoattractant protein-1 (MCP-1) than those from sham-operated mice. Increased fat resulting from estrogen deficiency is thus responsible for bone loss due to enhanced OC formation, which is, at least partly, a consequence of elevated MCP-1 production.
Kim
Youn-Young
YY
Department of Biological Sciences (Brain Korea 21 Program) and the Immunomodulation Research Center, University of Ulsan, Ulsan, 680-749, Korea.
Kim
Song-Hee
SH
Oh
Sora
S
Sul
Ok-Joo
OJ
Lee
Hye-Young
HY
Kim
Hyun-Ju
HJ
Kim
Shin-Yoon
SY
Choi
Hye-Seon
HS
D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D001862:Bone Resorption / Q000503:physiopathology*; D002454:Cell Differentiation / Q000502:physiology; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects; D018932:Chemokine CCL2 / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D004967:Estrogens / Q000172:deficiency*; D005260:Female; D005269:Femur / Q000737:chemistry / Q000473:pathology; D050152:Intra-Abdominal Fat / Q000378:metabolism / Q000473:pathology; D016173:Macrophage Colony-Stimulating Factor / Q000502:physiology; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D010010:Osteoclasts / Q000473:pathology*; D010052:Ovariectomy; D053245:RANK Ligand / Q000502:physiology; D011994:Recombinant Proteins / Q000494:pharmacology; D050151:Subcutaneous Fat / Q000378:metabolism / Q000473:pathology; D015430:Weight Gain
C491768:Ccl2 protein, mouse; D018932:Chemokine CCL2; D004967:Estrogens; D053245:RANK Ligand; D011994:Recombinant Proteins; C505689:Tnfsf11 protein, mouse; D016173:Macrophage Colony-Stimulating Factor