title: Synthesis and antimicrobial activity of some novel thiazolidine-2,4-dione derivatives.
abstract: In this study, a series of phenylethylsulfanyl-1,3-thiazolo-thiazolidine-2,4-dione derivatives (VII a-f, VIII a-f) and 5-methyl-[1,2,4]triazolyl-sulfanyl-1,3-thiazolo-thiazolidine-2,4-dione derivatives (IX a-f, X a-f) were synthesized and evaluated for their antibacterial and antifungal activities against S. aureus (ATCC 25923), methicillin resistant S. aureus (MRSA ATCC 43300), B. subtilis (ATCC 6633), E. coli (ATCC 23556) and C. albicans (ATCC10145). All the compounds were found active against used bacteria.
authors.affiliation: Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Tandogan, Ankara, Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Menteşe
authors.forename: Meltem
authors.initials: M
authors.lastname: Ceylan-Unlüsoy
authors.forename: Oya
authors.initials: O
authors.lastname: Bozdağ-Dündar
authors.forename: Nurten
authors.initials: N
authors.lastname: Altanlar
authors.forename: Rahmiye
authors.initials: R
authors.lastname: Ertan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D045162:Thiazolidinediones; C500090:thiazolidine-2,4-dione