[Effects of individual and combined administration of ethylmethylhydroxypyridine succinate and ischemic preconditioning on ischemic-reperfusive myocardial injury in rats].
It was shown previously that ethylmethylhydroxypyridine succinate (EMHPS) can produce metabolic cardioprotective action due to its antihypoxant and antioxidant properties. In the present study, the cardioprotective effects of EMHPS administered in doses 50 and 100 mg/kg alone and in combination with ischemic preconditioning have been studied on the model of ischemic-reperfusive myocardial infarction in rats. It is established that both the administration of EMHPS in a dose 50 mg/kg and the ischemic preconditioning produce significant limitation of the infarction size. A combined use of EMHPS in a dose of 50 mg/kg and ischemic preconditioning also provided significant protection, although the effect was not further potentiated. In contrast, EMHPS administered in a dose 100 mg/kg did not ensure reliable protection against infarction, while a combination of this drug dose with the ischemic preconditioning even partially eliminated the infarction-limiting effect of the latter.
Galagudza
M M
MM
Syrenskiĭ
A V
AV
Vlasov
T D
TD
Morozova
L Iu
LIu
Egorova
E I
EI
Polumiskov
V Iu
VIu
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D019157:Ischemic Preconditioning, Myocardial; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D011725:Pyridines; C517040:ethylmethylhydroxypyridine succinate