Inflammatory Bowel Diseases: the genetic revolution.
The genetic component of Inflammatory Bowel Diseases is among the best known for complex genetic disorders. If the functional candidate gene approach was rarely fruitful in the past, genome-wide scans allowed finding several susceptibility genes for Crohn disease including NOD2, IL23R, ATG16L1, IRGM, TNFSF15, a region close to PTGER4, PTPN2, PTPN22, NKX2-3 and many others. Only one gene, ECM1, has been reported for ulcerative colitis alone. We now need to further explore these new genes before to understand their biological role. However they clearly demonstrate the importance of innate immunity and autophagy for Crohn's disease and of the TH-17 differentiation for ulcerative colitis, Crohn's disease and other inflammatory disorders.
Jung
C
C
Hopital Robert Debré, Service de gastroentérologie et nutrition pédiatriques, 48, boulevard Sérurier, 75019 Paris, France.
Hugot
J-P
JP
D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins / Q000235:genetics; D003093:Colitis, Ulcerative / Q000235:genetics; D003424:Crohn Disease / Q000235:genetics; D016326:Extracellular Matrix Proteins / Q000235:genetics; D019204:GTP-Binding Proteins / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics; D054578:Protein Tyrosine Phosphatase, Non-Receptor Type 2 / Q000235:genetics; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics; D018123:Receptors, Interleukin / Q000235:genetics; D058309:Receptors, Prostaglandin E, EP4 Subtype / Q000235:genetics; D012307:Risk Factors; D014157:Transcription Factors / Q000235:genetics; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15 / Q000235:genetics
C518959:ATG16L1 protein, human; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins; C490607:ECM1 protein, human; D016326:Extracellular Matrix Proteins; D005819:Genetic Markers; D018398:Homeodomain Proteins; C515500:IL23R protein, human; C534957:NKX2-3 protein, human; D053473:Nod2 Signaling Adaptor Protein; C545650:PTGER4 protein, human; D018123:Receptors, Interleukin; D058309:Receptors, Prostaglandin E, EP4 Subtype; C117026:TNFSF15 protein, human; D014157:Transcription Factors; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15; C516649:PTPN2 protein, human; C516765:PTPN22 protein, human; D054578:Protein Tyrosine Phosphatase, Non-Receptor Type 2; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22; D019204:GTP-Binding Proteins; C513539:IRGM protein, human