title: Motility of the antroduodenum in healthy and gastroparetics characterized by wireless motility capsule.
abstract: BACKGROUND
  The wireless motility capsule (WMC) measures intraluminal pH and pressure, and records transit time and contractile activity throughout the gastrointestinal tract. Our hypothesis is that WMC can differentiate antroduodenal pressure profiles between healthy people and patients with upper gut motility dysfunctions. This study aims to analyze differences in the phasic pressure profiles of the stomach and small intestine in healthy and gastroparetic subjects.
  
  
  METHODS
  Data from 71 healthy and 42 gastroparetic subjects were analyzed. The number of contractions (Ct), area under the pressure curve and motility index (MI = Ln (Ct *sum amplitudes +1)) were analyzed for 60 min before gastric emptying of the capsule (GET), (gastric window) and after GET (small bowel window) and results between groups were compared with the Wilcoxon rank sum test.
  
  
  RESULTS
  Significant differences were observed between healthy and gastroparetic subjects for Ct and MI (P < 0.05). Median values of the motility parameters in gastric window were Ct = 72, MI = 11.83 for healthy and Ct = 47, MI = 11.12 for gastroparetics. In the small bowel, median values were Ct = 144.5, MI = 12.78 for healthy and Ct = 93, MI = 12.12 for gastroparetics. Diabetic subjects with gastroparesis showed significantly lower Ct and MI compared with healthy subjects in both gastric and small bowel windows while idiopathic gastroparetic subjects did not show significant differences.
  
  
  CONCLUSIONS
  The WMC is able to differentiate between healthy and gastroparetic subjects based on gastric and small bowel motility profiles.
authors.affiliation: Gastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
authors.forename: L
authors.initials: L
authors.lastname: Kloetzer
authors.forename: W D
authors.initials: WD
authors.lastname: Chey
authors.forename: R W
authors.initials: RW
authors.lastname: McCallum
authors.forename: K L
authors.initials: KL
authors.lastname: Koch
authors.forename: J M
authors.initials: JM
authors.lastname: Wo
authors.forename: M
authors.initials: M
authors.lastname: Sitrin
authors.forename: L A
authors.initials: LA
authors.lastname: Katz
authors.forename: J M
authors.initials: JM
authors.lastname: Lackner
authors.forename: H P
authors.initials: HP
authors.lastname: Parkman
authors.forename: G E
authors.initials: GE
authors.lastname: Wilding
authors.forename: J R
authors.initials: JR
authors.lastname: Semler
authors.forename: W L
authors.initials: WL
authors.lastname: Hasler
authors.forename: B
authors.initials: B
authors.lastname: Kuo
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D019540:Area Under Curve; D004386:Duodenum / Q000503:physiopathology*; D050782:Esophageal pH Monitoring; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology*; D018589:Gastroparesis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D018579:Patient Selection; D011706:Pyloric Antrum / Q000503:physiopathology*; D012737:Sex Factors