Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries.
In the present work we investigated the mechanism involved in the vasodilator effect induced by euxanthone in rat small mesenteric arteries. We observed that euxanthone induced concentration-dependent vasodilatation in arteries by a mechanism independent on the release of endothelial factors, such as nitric oxide (NO) and cyclooxygenase-derived factors. In addition our results also suggest that euxanthone induced its vasodilator effect through inhibition of calcium-sensitive mechanisms activated by protein kinase C, rather than by inhibition of contractions dependent on the release of the intracellular calcium stores or by inhibition of voltage-operated calcium channels.
Câmara
D V
DV
Departamento de Farmacologia, Instituto de Ciências Biológicas - Universidade Federal de Minas Gerais. Belo Horizonte - MG, Brazil.
Lemos
V S
VS
Santos
M H
MH
Nagem
T J
TJ
Cortes
S F
SF
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D028084:Clusiaceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014665:Vasodilator Agents / Q000494:pharmacology*; D044004:Xanthones / Q000494:pharmacology*
D015220:Calcium Channels; D010936:Plant Extracts; D014665:Vasodilator Agents; D044004:Xanthones; C404221:euxanthone; D011493:Protein Kinase C; D002118:Calcium