Propranolol for the treatment of a life-threatening subglottic and mediastinal infantile hemangioma.
An infant with a subglottic hemangioma remained in respiratory distress after multiple treatments failed and was found to have an enlarging mediastinal infantile hemangioma compressing the trachea. Treatment with oral propranolol resulted in resolution of symptoms within 2 days and a 50% reduction in lesion size within 1 week.
Truong
Mai Thy
MT
Division of Pediatric Otolaryngology, Lucile Packard Children's Hospital at Stanford, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Rd, Stanford, CA 94305, USA. kchang@stanfordmed.org
Chang
Kay W
KW
Berk
David R
DR
Heerema-McKenney
Amy
A
Bruckner
Anna L
AL
D000284:Administration, Oral; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000402:Airway Obstruction / Q000209:etiology; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006391:Hemangioma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007223:Infant; D007822:Laryngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008479:Mediastinal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use*; D012135:Respiratory Sounds / Q000209:etiology
D000319:Adrenergic beta-Antagonists; D018931:Antineoplastic Agents, Hormonal; D011239:Prednisolone; D011433:Propranolol