Mitotic functions of kinesin-5.
In all eukaryotic cells, molecular motor proteins play essential roles in spindle assembly and function. The homotetrameric kinesin-5 motors in particular generate outward forces that establish and maintain spindle bipolarity and contribute to microtubule flux. Cell-cycle dependent phosphorylation of kinesin-5 motors regulates their localization to the mitotic spindle. Analysis of live cells further shows that kinesin-5 motors are highly dynamic in the spindle. Understanding the interactions of kinesin-5 motors with microtubules and other spindle proteins is likely to broaden the documented roles of kinesin-5 motors during cell division.
Ferenz
Nick P
NP
Department of Biology, University of Massachusetts, Amherst, Morrill Science Center, Amherst, MA 01003, United States.
Gable
Alyssa
A
Wadsworth
Pat
P
D000818:Animals; D017173:Caenorhabditis elegans; D002453:Cell Cycle; D002455:Cell Division; D004398:Dyneins / Q000378:metabolism; D006801:Humans; D016547:Kinesins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D008938:Mitosis; D008954:Models, Biological; D010766:Phosphorylation; D012441:Saccharomyces cerevisiae; D008941:Spindle Apparatus
C470243:KIF11 protein, human; C500506:KIF5A protein, human; D004398:Dyneins; D016547:Kinesins