title: Henoch-Schönlein purpura in children from western Turkey: a retrospective analysis of 430 cases.
abstract: The medical records of children discharged with a diagnosis of Henoch-Schönlein purpura (HSP) between January 1996 and March 2006 were analyzed retrospectively. The patient population consisted of 430 children (225 boys, mean age: 7.9 +/- 2.9 years; range: 2-14 years). At onset, purpura was present in all cases, arthritis/arthralgias in 195 (45.3%), abdominal involvement in 148 (34.4%), and renal involvement in 192 (44.7%). Purpura manifested after 24 hours of admittance in 64 patients (14.9%) (atypical cases). Multivariate analysis showed that female sex, atypical presentation and early corticosteroid treatment increased the risk of renal involvement (p<0.05). Recurrences, occurring in 22 (5.2%) patients, were correlated with early corticosteroid treatment (p < 0.05). After a mean 17.3 +/- 2.9 months of follow-up, no patient had renal insufficiency. Female sex, atypical presentation and early corticosteroid treatment were considered to increase the risk of developing renal involvement, and relapses occurred more frequently in children treated with corticosteroid. Our study confirmed that HSP is generally a benign disease in children from western Turkey.
authors.affiliation: Department of Pediatrics, Tepecik Training and Research Hospital, Izmir, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Anil
authors.forename: Nejat
authors.initials: N
authors.lastname: Aksu
authors.forename: Orhan Deniz
authors.initials: OD
authors.lastname: Kara
authors.forename: Alkan
authors.initials: A
authors.lastname: Bal
authors.forename: Ayşe Berna
authors.initials: AB
authors.lastname: Anil
authors.forename: Onder
authors.initials: O
authors.lastname: Yavaşcan
authors.forename: Binnur
authors.initials: B
authors.lastname: Un
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008499:Medical Records; D015999:Multivariate Analysis; D012008:Recurrence; D051437:Renal Insufficiency / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D014421:Turkey
chemical_list: D000305:Adrenal Cortex Hormones