[Structural and functional properties of the C-terminal region of mitochondrial ADP/ATP carrier].
Mitochondrial ADP/ATP carrier (AAC) is a protein catalyzing the transport of adenine nucleotides across inner mitochondrial membrane. In this review article, we first briefly introduce structural and functional properties of this protein. Next, we describe the results of our recent studies on the difference in the C-terminal region between yeast type 2 AAC isoform and bovine type 1 AAC isoform. Furthermore, based on the reactivities of cysteine residues that replaced amino acids in the sixth transmembrane segment, the probable structural features of the C-terminal region of this carrier are discussed.
Shinohara
Yasuo
Y
Institute for Genome Research, University of Tokushima, Tokushima, Japan. yshinoha@genome.tokushima-u.ac.jp
Hashimoto
Mitsuru
M
Kihira
Yoshitaka
Y
Ohkura
Kazuto
K
Majima
Eiji
E
Terada
Hiroshi
H
D000227:Adenine Nucleotides / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D007527:Isoenzymes; D000226:Mitochondrial ADP, ATP Translocases / Q000737:chemistry* / Q000502:physiology*; D051336:Mitochondrial Membranes / Q000378:metabolism; D008969:Molecular Sequence Data; D029701:Saccharomyces cerevisiae Proteins
D000227:Adenine Nucleotides; D007527:Isoenzymes; C112225:PET9 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D000226:Mitochondrial ADP, ATP Translocases