Wilson's disease--a rare psychiatric presentation.
The development of extrapyramidal syndrome characterised by rigidity, bradykinesia, dysphagia and dysarthria in a male individual with four distinct episodes of (mania like) behavioural disturbances with fairly good remission in a time frame of five years, in a male individual, was suspected to develop the neurological manifestations of Wilson's disease and was investigated. In the absence of Kayser-Fleischer ring by slit-lamp examination and with normal copper and ceruloplasmin serum levels, the diagnosis was possible because of the positive findings of the magnetic resonance imaging (MRI) studies and increased 24 hours urinary copper levels with the penicillamine challenge test. The findings and its implications are highlighted and discussed.
Aravind
V K
VK
Ram Psychiatric Institute, Madurai 625020.
Krishnaram
V D
VD
Neethiarau
V
V
Srinivasan
K G
KG
D018759:Adrenergic Uptake Inhibitors / Q000627:therapeutic use; D000328:Adult; D001480:Basal Ganglia Diseases / Q000175:diagnosis* / Q000188:drug therapy; D003937:Diagnosis, Differential; D006527:Hepatolenticular Degeneration / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008297:Male; D018727:Muscarinic Antagonists / Q000627:therapeutic use; D013747:Tetrabenazine / Q000627:therapeutic use; D014282:Trihexyphenidyl / Q000627:therapeutic use
D018759:Adrenergic Uptake Inhibitors; D018727:Muscarinic Antagonists; D014282:Trihexyphenidyl; D013747:Tetrabenazine