title: [Structural and functional properties of the C-terminal region of mitochondrial ADP/ATP carrier].
abstract: Mitochondrial ADP/ATP carrier (AAC) is a protein catalyzing the transport of adenine nucleotides across inner mitochondrial membrane. In this review article, we first briefly introduce structural and functional properties of this protein. Next, we describe the results of our recent studies on the difference in the C-terminal region between yeast type 2 AAC isoform and bovine type 1 AAC isoform. Furthermore, based on the reactivities of cysteine residues that replaced amino acids in the sixth transmembrane segment, the probable structural features of the C-terminal region of this carrier are discussed.
authors.affiliation: Institute for Genome Research, University of Tokushima, Tokushima, Japan. yshinoha@genome.tokushima-u.ac.jp
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Shinohara
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kihira
authors.forename: Kazuto
authors.initials: K
authors.lastname: Ohkura
authors.forename: Eiji
authors.initials: E
authors.lastname: Majima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Terada
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D007527:Isoenzymes; D000226:Mitochondrial ADP, ATP Translocases / Q000737:chemistry* / Q000502:physiology*; D051336:Mitochondrial Membranes / Q000378:metabolism; D008969:Molecular Sequence Data; D029701:Saccharomyces cerevisiae Proteins
chemical_list: D000227:Adenine Nucleotides; D007527:Isoenzymes; C112225:PET9 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D000226:Mitochondrial ADP, ATP Translocases