Decreased innervation of eczematous skin in NC/Nga atopic mice during chronic mild stress.
OBJECTIVE
A connection between chronic mild stress and altered innervation in the skin of an atopic mouse strain, NC/Nga, was studied.


METHODS
We used three groups of mice, stressed control (SC, stressed but not immunized with a mite antigen), non-stressed eczematous (NSE, not stressed but immunized) and stressed eczematous (SE, stressed and immunized).


RESULTS
There was a decrease of protein gene product (PGP) 9.5 positive nerve fibers in SE compared to SC mice, in both epidermis and dermis, also in SE compared to NSE mice. Also a decrease in growth associated protein (GAP)-43 positive nerve fibers was seen in SE compared to SC, in both epidermis and dermis.


CONCLUSIONS
Chronic mild stress in atopic mice leads to decreased innervation in eczematous lesions.
Lönndahl
Louise
L
Karolinska Institutet, Department of Medicine Solna, Dermatology and Venereology Unit, Karolinska University Hospital, Stockholm Sweden. louise.lonndahl@ki.se
Lonne-Rahm
Sol-Britt
SB
Nordlind
Klas
K
Theodorsson
Elvar
E
El-Nour
Husameldin
H
D000818:Animals; D002908:Chronic Disease; D003345:Corticosterone / Q000097:blood; D004485:Eczema / Q000503:physiopathology*; D005260:Female; D019922:GAP-43 Protein / Q000032:analysis; D051379:Mice; D009416:Nerve Regeneration; D012867:Skin / Q000294:innervation*; D013315:Stress, Psychological / Q000503:physiopathology*; D043222:Ubiquitin Thiolesterase / Q000032:analysis
D019922:GAP-43 Protein; D043222:Ubiquitin Thiolesterase; C496976:Uchl1 protein, mouse; D003345:Corticosterone