title: The pharmacological efficacy of mycophenolic acid before and after renal transplantation as estimated by the lymphocyte immunosuppressant sensitivity test (LIST).
abstract: The lymphocyte immunosuppressant sensitivity test (LIST) can predict the pharmacological efficacy of immunosuppressive agents. We herein estimated the mycophenolic acid efficacy using LIST before and 1, 3, and 12 months after the operation in 15 renal transplant recipients. The pharmacological efficacy of mycophenolic acid as assessed before transplantation showed small individual variations, whereas the variability greatly increased at 1 and 3 months after transplantation. Furthermore, the individual IC50 variation among these subjects at 1-year after operation was closely similar to that observed before surgery. No significant implications of these individual differences in the mycophenolic acid sensitivity were noted in regard to the clinical courses of these recipients.
authors.affiliation: Division of Pharmacy, Niigata University Medical and Dental Hospital, Niigata, Niigata, Japan. sugiyama-nii@umin.ac.jp
authors.forename: Kentaro
authors.initials: K
authors.lastname: Sugiyama
authors.forename: Kazuya
authors.initials: K
authors.lastname: Isogai
authors.forename: Satoshi
authors.initials: S
authors.lastname: Horisawa
authors.forename: Akira
authors.initials: A
authors.lastname: Toyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Satoh
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Saito
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tasaki
authors.forename: Kota
authors.initials: K
authors.lastname: Takahashi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Hirano
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use; D000077552:Basiliximab; D016572:Cyclosporine / Q000494:pharmacology / Q000627:therapeutic use; D004351:Drug Resistance; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007159:Immunologic Tests; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology*; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D011993:Recombinant Fusion Proteins / Q000494:pharmacology / Q000627:therapeutic use; D016559:Tacrolimus / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D007166:Immunosuppressive Agents; D011993:Recombinant Fusion Proteins; D016572:Cyclosporine; D000077552:Basiliximab; D009173:Mycophenolic Acid; D016559:Tacrolimus; D008775:Methylprednisolone