title: Physical activity at midlife in relation to successful survival in women at age 70 years or older.
abstract: BACKGROUND
  Physical activity is associated with reduced risks of chronic diseases and premature death. Whether physical activity is also associated with improved overall health among those who survive to older ages is unclear.
  
  
  METHODS
  A total of 13,535 Nurses' Health Study participants who were free of major chronic diseases at baseline in 1986 and had survived to age 70 years or older as of the 1995-2001 period made up the study population. We defined successful survival as no history of 10 major chronic diseases or coronary artery bypass graft surgery and no cognitive impairment, physical impairment, or mental health limitations.
  
  
  RESULTS
  After multivariate adjustment for covariates, higher physical activity levels at midlife, as measured by metabolic-equivalent tasks, were significantly associated with better odds of successful survival. Significant increases in successful survival were observed beginning at the third quintile of activity: odds ratios (ORs) (95% confidence intervals [CIs]) in the lowest to highest quintiles were 1 [Reference], 0.98 (0.80-1.20), 1.37 (1.13-1.65), 1.34 (1.11-1.61), and 1.99 (1.66-2.38) (P < .001 for trend). Increasing energy expenditure from walking was associated with a similar elevation in odds of successful survival: the ORs (95% CIs) of successful survival across quintiles of walking were 1 [Reference], 0.99 (0.80-1.21), 1.19 (0.97-1.45), 1.50 (1.24-1.82), and 1.47 (1.22-1.79) (P < .001 for trend).
  
  
  CONCLUSIONS
  These data provide evidence that higher levels of midlife physical activity are associated with exceptional health status among women who survive to older ages and corroborate the potential role of physical activity in improving overall health.
authors.affiliation: Department of Nutrition, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA. qisun@hsph.harvard.edu
authors.forename: Qi
authors.initials: Q
authors.lastname: Sun
authors.forename: Mary K
authors.initials: MK
authors.lastname: Townsend
authors.forename: Olivia I
authors.initials: OI
authors.lastname: Okereke
authors.forename: Oscar H
authors.initials: OH
authors.lastname: Franco
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
authors.forename: Francine
authors.initials: F
authors.lastname: Grodstein
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D003071:Cognition; D004734:Energy Metabolism; D015444:Exercise; D005260:Female; D006304:Health Status; D006801:Humans; D008136:Longevity; D008137:Longitudinal Studies; D008603:Mental Health; D008875:Middle Aged