title: Antiangiogenic therapy in the treatment of recurrent medulloblastoma in the adult: case report and review of the literature.
abstract: Medulloblastoma is a rare tumor in central nervous system, with an even rarer occurrence in adulthood. The management of a recurrent disease is a medical challenge; chemotherapy has been used as the treatment of choice, while reirradiation has been employed in selected cases. We report the case of a 51-year-old man with recurrent medulloblastoma. He was treated with local reirradiation, chemotherapy, and antiangiogenic drug, with the latter giving the longer progression-free interval. The aim of this report is to show that recurrent medulloblastoma in adults can be approached with a multimodality treatment and that antiangiogenic therapy should have a role in the management of this disease.
authors.affiliation: U.O. Radiodiagnostica e Radioterapia Oncologica, AOU Policlinico "G. Rodolico"-Catania, Via Santa Sofia 78-95125-Catania, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Privitera
authors.forename: Grazia
authors.initials: G
authors.lastname: Acquaviva
authors.forename: Giovanni Carlo
authors.initials: GC
authors.lastname: Ettorre
authors.forename: Corrado
authors.initials: C
authors.lastname: Spatola