Kinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzone.
In mammalian cultured cells the initiation of cytokinesis is regulated - both temporally and spatially - by the overlapping, anti-parallel microtubules of the spindle midzone. This region recruits several key central spindle components: PRC-1, polo-like kinase 1 (Plk-1), the centralspindlin complex, and the chromosome passenger complex (CPC), which together serve to stabilize the microtubule overlap, and also to coordinate the assembly of the cortical actin/myosin cytoskeleton necessary to physically cleave the cell in two. The localization of these crucial elements to the spindle midzone requires members of the kinesin superfamily of microtubule-based motor proteins. Here we focus on reviewing the role played by a variety of kinesins in both building and operating the spindle midzone machinery during cytokinesis.
Hornick
Jessica E
JE
Department of Obstetrics and Gynecology, and Robert H. Lurie Cancer Center, Northwestern University School of Medicine, Chicago, IL 60611, USA.
Karanjeet
Kul
K
Collins
Elizabeth S
ES
Hinchcliffe
Edward H
EH
D000199:Actins / Q000378:metabolism; D000205:Actomyosin / Q000737:chemistry; D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism; D048749:Cytokinesis; D006801:Humans; D016547:Kinesins / Q000502:physiology*; D008868:Microtubule Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D008938:Mitosis; D008954:Models, Biological; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D008941:Spindle Apparatus; D000097869:Polo-Like Kinase 1
D000199:Actins; D000205:Actomyosin; D018797:Cell Cycle Proteins; D016547:Kinesins; D008868:Microtubule Proteins; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D000097869:Polo-Like Kinase 1