title: Partial and transitional atrioventricular septal defect outcomes.
abstract: BACKGROUND
  Surgical and perioperative improvements permit earlier repair of partial and transitional atrioventricular septal defects (AVSD). We sought to describe contemporary outcomes in a multicenter cohort.
  
  
  METHODS
  We studied 87 patients undergoing primary biventricular repair of partial or transitional AVSD between June 2004 and February 2006 across seven North American centers. One-month and 6-month postoperative data included weight-for-age z-scores, left atrioventricular valve regurgitation (LAVVR) grade, residual shunts, and left ventricular ejection fraction. Paired methods were used to assess 6-month change.
  
  
  RESULTS
  Median age at surgery was 1.8 years; median weight z-score was -0.88. Median days for ventilation were 1, intensive care 2, and hospitalization 5, all independent of age, with 1 in-hospital death. At 1 month, 27% (16 of 73) had ejection fraction less than 55%; 20% (17 of 87) had significant LAVVR; 2 had residual shunts; 1 each had subaortic stenosis and LAVV stenosis. At 6 months (n = 60), there were no interim deaths, reinterventions, or new development of subaortic or LAVV stenosis. Weight z-score improved by a median 0.4 units (p < 0.001), especially for underweight children less than 18 months old. Left atrioventricular valve regurgitation occurred in 31% (change from baseline, p = 0.13), occurring more frequently in patients repaired at 4 to 7 years (p = 0.01). Three patients had ejection fraction less than 55%, and 1 had a residual atrial shunt.
  
  
  CONCLUSIONS
  Surgical repair for partial/transitional AVSD is associated with low morbidity and mortality, short hospital stays, and catch-up growth, particularly in underweight children repaired between 3 and 18 months of age. Left atrioventricular valve regurgitation remains the most common residual defect, occurring more frequently in children repaired after 4 years of age.
authors.affiliation: University of Utah, Salt Lake City, Utah, USA. luann.minich@imail.org
authors.forename: L LuAnn
authors.initials: LL
authors.lastname: Minich
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Atz
authors.forename: Steven D
authors.initials: SD
authors.lastname: Colan
authors.forename: Lynn A
authors.initials: LA
authors.lastname: Sleeper
authors.forename: Seema
authors.initials: S
authors.lastname: Mital
authors.forename: James
authors.initials: J
authors.lastname: Jaggers
authors.forename: Renee
authors.initials: R
authors.lastname: Margossian
authors.forename: Ashwin
authors.initials: A
authors.lastname: Prakash
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Li
authors.forename: Meryl S
authors.initials: MS
authors.lastname: Cohen
authors.forename: Ronald V
authors.initials: RV
authors.lastname: Lacro
authors.forename: Gloria L
authors.initials: GL
authors.lastname: Klein
authors.forename: John A
authors.initials: JA
authors.lastname: Hawkins
mesh_terms: D000367:Age Factors; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000401:mortality / Q000601:surgery*; D006344:Heart Septal Defects, Atrial / Q000401:mortality / Q000601:surgery*; D006345:Heart Septal Defects, Ventricular / Q000401:mortality / Q000601:surgery*; D006439:Hemodynamics / Q000502:physiology; D017052:Hospital Mortality; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007902:Length of Stay; D008297:Male; D008944:Mitral Valve Insufficiency / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D011183:Postoperative Complications / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D011379:Prognosis; D011446:Prospective Studies; D012086:Reoperation; D016896:Treatment Outcome; D014262:Tricuspid Valve Insufficiency / Q000209:etiology / Q000503:physiopathology / Q000601:surgery