Demand-specific alteration of medial prefrontal cortex response during an inhibition task in recovered anorexic women.
OBJECTIVE
It is well known that individuals with anorexia nervosa (AN) are inhibited and over-controlled. This study investigated a prefrontal-cingulate network that is involved in inhibitory control.


METHODS
To avoid the confounds of malnutrition, 12 recovered (RAN) subjects were compared to 12 matched control women (CW) using a validated inhibition task (i.e., a stop signal task) during functional magnetic resonance imaging.


RESULTS
Consistent with the a priori hypothesis, RAN subjects showed altered task-related activation in the medial prefrontal cortex (mPFC), a critical node of the inhibitory control network. Specifically, whereas RAN and CW showed similar mPFC activity during trials when inhibitory demand was low (i.e., easy trials), RAN relative to CW showed significantly less mPFC activation as inhibition trials became more difficult (i.e., hard trials), suggesting a demand-specific modulation of inhibitory control circuitry in RAN.


CONCLUSIONS
These findings support a neural basis for altered impulse control symptoms in AN.
Oberndorfer
Tyson A
TA
Department of Psychiatry, University of California-San Diego, La Jolla, CA 92037, USA.
Kaye
Walter H
WH
Simmons
Alan N
AN
Strigo
Irina A
IA
Matthews
Scott C
SC
D000328:Adult; D000856:Anorexia Nervosa / Q000503:physiopathology* / Q000534:rehabilitation; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000503:physiopathology; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D017397:Prefrontal Cortex / Q000502:physiology*; D013647:Task Performance and Analysis; D055815:Young Adult