[Genetic epidemiology--from gene to disease understanding].
Both genetic and environmental factors contribute to the aetiology of many common diseases. Recently, progress has been made in the identification of susceptibility genes by candidate gene and genome-wide association studies. Thereby, a further molecular understanding of pathophysiological pathways has been obtained and the development of new therapeutic modalities based on rational drug design has been initiated. However, a host of methods and approaches are necessary to further increase the knowledge on the aetiology of the complex diseases.
Andersen
Vibeke Charlotte
VC
Medicinsk Afdeling, Regionshospitalet Viborg, DK-8800 Viborg, Denmark. Vibeke.andersen@viborg.rm.dk
Vogel
Ulla
U
D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D017720:Molecular Epidemiology; D010641:Phenotype