title: [Defective placental implantation and its effects on maternal endothelial function].
abstract: Preeclampsia, a pregnancy-specific syndrome characterized by hypertension, edema and proteinuria, resolves spontaneously on placental delivery. Its pathogenesis is thought to involve placental hypoxia, which leads to maternal vascular dysfunction through increased placental release of anti-angiogenic factors such as the soluble form of VEGF receptor-1 (VEGFR1). VEGFR1 binds VEGF and PIGF, which are also produced by villous trophoblastic cells. In the absence of VEGF and PIGF in the maternal circulation, endothelial dysfunction occurs in several vascular territories (liver, kidneys, brain, heart, lungs, etc.). In experimental models, sVEGFR1 not only has an anti-angiogenic action but also augments endothelial expression of NO synthase through intracellular transduction. When NO production is increased, pericytes and perivascular smooth muscle cells are recruited and their adhesion to endothelial cells is strongly stimulated. This can hinder both trophoblast invasion and increase uteroplacental flow during preeclampsia.
authors.affiliation: Gynécologie-Obstétrique, Université de Liège, Hôpital de la Citadelle, 1 boulevard du 12e ligne, B-4000 Liège, Belgique. eliane.welliquet@chrcitadelle.be
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Foidart
authors.forename: Agnès
authors.initials: A
authors.lastname: Noël
authors.forename: Frédéric
authors.initials: F
authors.lastname: Chantraine
authors.forename: Sophie
authors.initials: S
authors.lastname: Lorquet
authors.forename: Philippe
authors.initials: P
authors.lastname: Petit
authors.forename: Carine
authors.initials: C
authors.lastname: Munaut
authors.forename: Sarah
authors.initials: S
authors.lastname: Berndt
authors.forename: Christel
authors.initials: C
authors.lastname: Pequeux
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Schaaps
mesh_terms: D010064:Embryo Implantation / Q000502:physiology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D010920:Placenta / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000209:etiology; D011247:Pregnancy