Chloride channels of intracellular membranes.
Proteins implicated as intracellular chloride channels include the intracellular ClC proteins, the bestrophins, the cystic fibrosis transmembrane conductance regulator, the CLICs, and the recently described Golgi pH regulator. This paper examines current hypotheses regarding roles of intracellular chloride channels and reviews the evidence supporting a role in intracellular chloride transport for each of these proteins.
Edwards
John C
JC
UNC Kidney Center and the Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, USA. jedwards@med.unc.edu
Kahl
Christina R
CR
D000818:Animals; D001692:Biological Transport; D018118:Chloride Channels / Q000378:metabolism*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*
D018118:Chloride Channels