title: Dammarane-type glycosides from Gynostemma pentaphyllum and their effects on IL-4-induced eotaxin expression in human bronchial epithelial cells.
abstract: Two new dammarane-type glycosides, 2alpha,3beta,12beta,20S-tetrahydroxydammar-24-ene-3-O-[beta-d-glucopyranosyl(1-->4)-beta-d-glucopyranosyl]-20-O-[beta-d-xylopyranosyl-(1-->6)-beta-d-glucopyranoside] (1) and 2alpha,3beta,12beta,20S-tetrahydroxydammar-24-ene-3-O-beta-d-glucopyranosyl-20-O-[beta-d-6-O-acetylglucopyranosyl-(1-->2)-beta-d-glucopyranoside] (2), were isolated from a MeOH extract of the leaves of Gynostemma pentaphyllum. Their structures were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical studies. The isolated compounds showed potential inhibitory effects on eotaxin expression in BEAS-2B bronchial epithelial cells.
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Kyeongbuk 712-702, Korea.
authors.forename: Tran Manh
authors.initials: TM
authors.lastname: Hung
authors.forename: Cao Van
authors.initials: CV
authors.lastname: Thu
authors.forename: To Dao
authors.initials: TD
authors.lastname: Cuong
authors.forename: Nguyen Phi
authors.initials: NP
authors.lastname: Hung
authors.forename: Seung Jun
authors.initials: SJ
authors.lastname: Kwack
authors.forename: Jung-Im
authors.initials: JI
authors.lastname: Huh
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
authors.forename: Jae Sue
authors.initials: JS
authors.lastname: Choi
authors.forename: Hyeong Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: KiHwan
authors.initials: K
authors.lastname: Bae
mesh_terms: D001980:Bronchi / Q000166:cytology / Q000187:drug effects; D004847:Epithelial Cells / Q000187:drug effects; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029774:Gynostemma / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014744:Vietnam; D000097669:Dammaranes
chemical_list: D005960:Glucosides; D006027:Glycosides; D014315:Triterpenes; D000097669:Dammaranes; C548100:2alpha,3beta,12beta,20S-tetrahydroxydammar-24-ene-3-O-(beta-D-glucopyranosyl(1-4)-beta-D-glucopyranosyl)-20-O-(beta-D-xylopyranosyl-(1-6)-beta-D-glucopyranoside); C548101:2alpha,3beta,12beta,20S-tetrahydroxydammar-24-ene-3-O-beta-D-glucopyranosyl-20-O-(beta-D-6-O-acetylglucopyranosyl-(1-2)-beta-D-glucopyranoside)