[Hereditary tylosis syndrome and esophagus cancer].
Tylosis palmoplantaris is an autosomal dominant disorder characterized by hyperkeratosis of palms and soles. Lesions start during childhood and are more evident in areas of pressure. Familial tylosis palmoplantaris comprises two forms: epidermolytic and non-epidermolytic. Patients with the epidermolytic variant have up to 40% higher chance of developing squamous cell carcinoma of the esophagus. The association of tylosis palmoplantaris with esophageal cancer is called Howel-Evans syndrome.
de Souza
Camila Alves
CA
Faculdade de Medicina do Vale do Aço, Ipatinga, MG, Brasil. kkmedicina@yahoo.com.br
Santos
Allan da Costa
Ada C
Santos
Lennon da Costa
Lda C
Carneiro
Artur Leonel
AL
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D004938:Esophageal Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D015776:Keratoderma, Palmoplantar, Diffuse / Q000150:complications* / Q000235:genetics