Pharmacoepidemiological research using French reimbursement databases: yes we can!
OBJECTIVE
To describe the reimbursement databases available in France for pharmacoepidemiological research and their use.


METHODS
France has a publicly funded health system that systematically covers the population. Within this system, three main insurance schemes provide health services to citizens in France and each have their own reimbursement database. Together these three databases cover almost 97% of the French population (respectively for 54.5, 3.6, and 3.3 million individuals, and a total of 61.4 million individuals). Data in these concern patients, prescribers, all the medical acts reimbursed, prescription and undertaking of laboratory tests (but without results), private hospital data, partial public hospital data and vital status. Their use is regulated but access is free and the data are anonymous. PubMed and Scopus were searched for relevant studies published from January 1988 to June 2009.


RESULTS
110 published studies were included. The topics and the study characteristics were extremely wide-ranging. The studies assessed patterns of drug use, have tested interventions, supported or improved prescribing practices, tested compliance with the French governmental Health guidelines, assessed physicians' prescribing practices and performed economic and cost-effectiveness assessments. The number of articles published increased greatly between 2002 and 2003.


CONCLUSIONS
The French reimbursement databases were greatly used over the last 20 years. They can provide data on exposure to drugs and can be used to study patterns of drug utilization although their limitations must be considered.
Martin-Latry
Karin
K
Département de Pharmacologie, Université Victor Segalen Bordeaux 2, 33076 Bordeaux, France. karin.latry@u-bordeaux2.fr
Bégaud
Bernard
B
D016208:Databases, Factual / Q000706:statistics & numerical data*; D017850:Economics, Pharmaceutical; D005602:France; D019983:Guideline Adherence; D006801:Humans; D007349:Insurance, Health, Reimbursement / Q000706:statistics & numerical data*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000191:economics; D017891:Pharmacoepidemiology / Q000379:methods*; D010818:Practice Patterns, Physicians'
D004364:Pharmaceutical Preparations