SNPs in CAST are associated with Parkinson disease: a confirmation study.
Using data from the National Institutes of Neurological disease and Stroke's (NINDS) study of Parkinson disease (PD), we recently reported that single nucleotide polymorphisms (SNPs) in a region containing the Calpastatin (CAST) gene were associated with PD. Here we follow up this finding with an analysis of the Center for Inherited Disease Research's (CIDR) genome-wide association study in familial PD. After adjusting for population stratification and multiple testing, we find a significant association (P = 0.0167) between PD and SNP rs1559085 in CAST. These findings confirm CAST/PD associations in a second, independent, dataset and suggest that CAST be prioritized for further investigation.
Allen
Andrew S
AS
Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA. andrew.s.allen@duke.edu
Satten
Glen A
GA
D002135:Calcium-Binding Proteins / Q000235:genetics*; D016022:Case-Control Studies; D055106:Genome-Wide Association Study; D006801:Humans; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D002135:Calcium-Binding Proteins; C033668:calpastatin