The contribution of Asian researchers to the field of rheumatology.
Asia is home to more than half of the world's population and is a region of diverse ethnicity, culture, microbial endemicity, and economic backgrounds. This diversity is also reflected in the heterogeneity among Asian patients with rheumatic diseases in terms of clinical manifestations, disease courses, treatment responses and outcomes, which provides opportunities for researchers to conduct some unique studies. Several disease entities, such as Behçet syndrome, Takayasu arteritis, Kawasaki disease, and immunological disorders associated with human T-lymphotropic virus type 1 (HTLV-1), were first observed and defined in Asia. In addition, the region's researchers have been at the forefront of research in some interesting scientific topics, which has opened up new research avenues in rheumatology, such as the direct targeting of synovial cells in patients with rheumatoid arthritis via activation of the agonistic Fas pathway, establishment of the field of osteoimmunology, the discovery of regulatory T cells and synoviolin, and the development of tocilizumab, a humanized monoclonal antibody against interleukin-6 receptor.
Yamano
Yoshihisa
Y
Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, 2-16-1 Sugao, Miyamae-ku, Kawasaki-shi, Kanagawa, Japan.
Nishioka
Kusuki
K
D001208:Asia / Q000453:epidemiology; D006801:Humans; D012216:Rheumatic Diseases / Q000453:epidemiology* / Q000628:therapy; D012219:Rheumatology / Q000639:trends*