title: [Functional MRI in normal subjects and sudden unilateral sensorineural hearing loss patients].
abstract: OBJECTIVE
  Brain activities in responses to amplitude modulation (AM) was evaluated using functional MRI (fMRI) in subjects with sudden unilateral sensorineural hearing loss (SSNHL) and those with normal hearing (NH).
  
  
  METHODS
  Totally 25 subjects with normal hearing and 30 with SSNHL were examined with fMRI in response to AM tones of 500, 2000 and 4000 Hz respectively with the modulation frequency at 8 Hz. The fMRI was examined within 12 days after the onset of SSNHL. The AM signals were presented at 96 dB SPL binaurally. An event-related design was combined with a sparse clustered volume acquisitioning paradigm in data collection in the attempt to reduce the influence of acoustic scanner noise. SPM2 software was used for offline data analyzing.
  
  
  RESULTS
  Brain activation in fMRI image was found mainly in the primary auditory cortex (PAC) in both subjects with NH and SSNHL NH subjects showed a clear lateralization to left cerebral hemisphere(11/16) and SSNHL patients showed a lateralization ipsilateral to the impaired ear(16/22). The activation voxel and intensity shown in BOLD were found to be decreased with increasing signal frequency in both groups.
  
  
  CONCLUSIONS
  The difference in the lateralization between the two groups suggests that an adaptive process occurs shortly after the onset of SSNHL
authors.affiliation: Department of Radiology, Zhongda Hospital of Southeast University, Nanjing 210009, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Gao-Jun
authors.initials: GJ
authors.lastname: Teng
authors.forename: Zhi-Chun
authors.initials: ZC
authors.lastname: Huang
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Gao
authors.forename: Hui
authors.initials: H
authors.lastname: Ji
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.forename: Xu
authors.initials: X
authors.lastname: Feng
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D001303:Auditory Cortex / Q000502:physiology / Q000503:physiopathology; D001931:Brain Mapping; D016022:Case-Control Studies; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D055815:Young Adult