title: Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure.
abstract: The natural tetracyclic schweinfurthins are potent and selective inhibitors of cell growth in the National Cancer Institute's 60-cell line screen. An interest in determination of their cellular or molecular target has inspired our efforts to prepare both the natural products and analogues. In this paper, chemical synthesis of analogues modified in different olefinic positions, and preliminary results from studies of their biological activity, are reported.
authors.affiliation: Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA.
authors.forename: Natalie C
authors.initials: NC
authors.lastname: Ulrich
authors.forename: John G
authors.initials: JG
authors.lastname: Kodet
authors.forename: Nolan R
authors.initials: NR
authors.lastname: Mente
authors.forename: Craig H
authors.initials: CH
authors.lastname: Kuder
authors.forename: John A
authors.initials: JA
authors.lastname: Beutler
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Hohl
authors.forename: David F
authors.initials: DF
authors.lastname: Wiemer
mesh_terms: D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015335:Molecular Probes; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D013267:Stilbenes / Q000737:chemistry*
chemical_list: D015335:Molecular Probes; D013267:Stilbenes; C518723:schweinfurthin F