Antimicrobial nucleoside antibiotics targeting cell wall assembly: recent advances in structure-function studies and nucleoside biosynthesis.
The quest for new antibiotics, especially those with activity against Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in the last 40 years, with this limited number falling into only four new structural classes. Several nucleoside natural product antibiotics target bacterial translocase MraY, involved in the lipid-linked cycle of peptidoglycan biosynthesis, and fungal chitin synthase. Biosynthetic studies on the nikkomycin, caprazamycin and pacidamycin/mureidomycin families are also reviewed.
Winn
Michael
M
School of Chemistry, University of East Anglia, Norwich, NR4 7TJ, UK.
Goss
Rebecca J M
RJ
Kimura
Ken-ichi
K
Bugg
Timothy D H
TD
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D015394:Molecular Structure; D009705:Nucleosides / Q000378:metabolism*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D009705:Nucleosides