Cardiocirculatory changes in hemorrhagic shock induced in pigs submitted to three distinct therapeutic methods.
OBJECTIVE
To evaluate and compare the response of pigs submitted to hemorrhagic shock and treated using three different strategies.


METHODS
Thirty-five Dalland pigs were divided into four groups: Control; Bleeding; Saline and Saline + Red Cell Concentrate. Parameters evaluated: heart rate (HR), mean arterial blood pressure (MAP) and central vein pressure (CVP).Hemorrhagic shock was induced by removing (624.25 + or - 64.55), (619.30 + or - 44.94) and (664.23 + or - 39.96) ml of blood respectively, with the following treatment: Bleeding Group - zero volume replacement; Saline Group - replacement with 676 ml of 0.9% saline solution; Saline + Red Cell Concentrate Group - replacement with 440 ml of 0.9% saline solution + 291 ml of red cell concentrate. The treatment was evaluated after 10 (T3), 30 (T4), 45 (T5) and 60 (T6) minutes.


RESULTS
HR: No statistically significant difference was found between the Bleeding and Saline [p=1.000], Bleeding and Saline + Red Cell Concentrate [p=1.000], and Saline and Saline + Red Cell Concentrate [p=0.721] groups. MAP; Significant differences were found between all the groups studied. CVP: No significant difference was found between the groups.


CONCLUSIONS
Non-replacement and euvolemic resuscitation maintained a satisfactory hemodynamic pattern in controlled severe hemorrhagic shock in swine. The euvolemic replacement strategies exceeded the limit values of MAP for rebleeding.
Abreu
Gilberto Fernandes Silva de
GF
Department of Surgery, UFPE, Recife, PE, Brazil. gabreu01@uol.com.br
Coelho
Antônio Roberto Barros
AR
Aguiar
José Lamartine de Andrade
JL
Moura Filho
Sílvio Amorim
SA
D000818:Animals; D001802:Blood Substitutes / Q000494:pharmacology*; D004195:Disease Models, Animal; D005440:Fluid Therapy / Q000379:methods*; D006439:Hemodynamics / Q000187:drug effects*; D007552:Isotonic Solutions / Q000494:pharmacology*; D011897:Random Allocation; D012771:Shock, Hemorrhagic / Q000139:chemically induced / Q000188:drug therapy*; D013552:Swine
D001802:Blood Substitutes; D007552:Isotonic Solutions