Molecular imaging in gastrointestinal endoscopy.
Molecular imaging is a rapidly growing new discipline in gastrointestinal endoscopy. It uses the molecular signature of cells for minimally-invasive, targeted imaging of gastrointestinal pathologies. Molecular imaging comprises wide field techniques for the detection of lesions and microscopic techniques for in vivo characterization. Exogenous fluorescent agents serve as molecular beacons and include labeled peptides and antibodies, and probes with tumor-specific activation. Most applications have aimed at improving the detection of gastrointestinal neoplasia with either prototype fluorescence endoscopy or confocal endomicroscopy, and first studies have translated encouraging results from rodent and tissue models to endoscopy in humans. Even with the limitations of the currently used approaches, molecular imaging has the potential to greatly impact on future endoscopy in gastroenterology.
Goetz
Martin
M
I. Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstr. 1, D-55131 Mainz, Germany. mgoetz@mail.uni-mainz.de
Wang
Thomas D
TD
D000818:Animals; D003287:Contrast Media; D020776:Endoscopes, Gastrointestinal; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D004867:Equipment Design; D005456:Fluorescent Dyes; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D018613:Microscopy, Confocal / Q000295:instrumentation; D008856:Microscopy, Fluorescence / Q000295:instrumentation; D057054:Molecular Imaging / Q000295:instrumentation; D011237:Predictive Value of Tests
D003287:Contrast Media; D005456:Fluorescent Dyes