Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: furan (CAS No. 110-00-9).
Furan is commonly found in foods such as coffee, canned and jarred foods, including baby food containing meat, and various vegetables. It is thought to be formed by the thermal decomposition of carbohydrates. Furan is carcinogenic in rodents, although the detailed mechanism of action has not been completely established, for all the tumour types induced. Dose-response modelling of the data for hepatocellular tumours gives a BMDL10 of 1.23 mg/kg/day, and MOEs of between 750 and 4300 for exposures of infants and adults.
Carthew
Philip
P
Unilever Research, UK. publications@ilsieurope.be
DiNovi
Michael
M
Setzer
R Woodrow
RW
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D003627:Data Interpretation, Statistical; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D005663:Furans / Q000633:toxicity*; D006801:Humans; D008297:Male; D051379:Mice; D015233:Models, Statistical; D009153:Mutagens / Q000633:toxicity*; D051381:Rats
D002273:Carcinogens; D005663:Furans; D009153:Mutagens