Towards characteristics of photodynamic drugs specifically aimed at microvascular diseases.
Photodynamic therapy (PDT) is a versatile methodology to treat various diseases but the drugs (photosensitizers) specifically aimed at individual character of diseases are urgently needed. Among those, the perilenoquinoid photosensitizers were thought of low PDT effectiveness to solid tumors due to low absorption on the "photodynamic window" but may be specially suitable for PDT to some microvascular diseases, such as age-related macular degeneration (AMD) and port wine stains (PWS), as well as other superficial diseases. Two strategies were discussed to convert the photosensitizers into clinically acceptable drugs in consideration of the drug-delivery and biological activity.
Zhao
Jingquan
J
Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China. zhaojq@iccas.ac.cn
Deng
Hong
H
Xie
Jie
J
Liu
Xin
X
Zhang
Yang
Y
Huang
Naiyan
N
Gu
Ying
Y
D000818:Animals; D006801:Humans; D055806:Microvessels / Q000187:drug effects* / Q000528:radiation effects*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000494:pharmacology / Q000627:therapeutic use; D014652:Vascular Diseases / Q000188:drug therapy*
D017319:Photosensitizing Agents