New phenolic glycosides from Securinega virosa and their antioxidant activity.
One new flavonoid glycoside, 3-O-kaempferol 4-O-(galloyl)-beta-D-glucoside, one new bergenin derivative, 11-0-caffeoylbergenin, along with other known flavonoids and phenolic derivatives, were isolated from the leaves of Securinega virosa. Their structures were established on the basis of detailed spectral analysis. In vitro biological analysis of the isolated compounds showed that they were able to quench DPPH radicals and had a direct scavenging activity on superoxide anion. Kaempferol 3-O-(4-galloyl)-beta-D-glucopyranoside (1), 11-0-caffeoylbergenin (2), and glucogallin (6) exhibited the highest antioxidant capacity, being also able to modulate hydroxyl radical formation more efficiently than the other compounds, acting as direct hydroxyl radical scavengers and chelating iron.
Sanogo
Rokia
R
Departement Medicine Traditionelle (DMT), INRSP, B.P. 1746, Bamako, Mali.
Vassallo
Antonio
A
Malafronte
Nicola
N
Imparato
Salvatore
S
Russo
Alessandra
A
Dal Piaz
Fabrizio
F
D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D001578:Benzopyrans / Q000737:chemistry* / Q000302:isolation & purification; D001713:Biphenyl Compounds; D002614:Chelating Agents / Q000737:chemistry; D018744:DNA, Plant / Q000187:drug effects / Q000528:radiation effects; D019665:Euphorbiaceae / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification; D006868:Hydrolysis; D044949:Kaempferols / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry; D000432:Methanol; D008968:Molecular Conformation; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D010851:Picrates; D018515:Plant Leaves / Q000737:chemistry; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization; D013481:Superoxides / Q000737:chemistry; D014466:Ultraviolet Rays
C547462:11-0-caffeoylbergenin; C547461:3-O-kaempferol 4-O-(galloyl)-beta-D-glucoside; D000975:Antioxidants; D001578:Benzopyrans; D001713:Biphenyl Compounds; D002614:Chelating Agents; D018744:DNA, Plant; D005960:Glucosides; D006027:Glycosides; D044949:Kaempferols; D008670:Metals; D010636:Phenols; D010851:Picrates; D012997:Solvents; D013481:Superoxides; C004931:1,1-diphenyl-2-picrylhydrazyl; D000432:Methanol