Iridium-catalyzed asymmetric ring-opening reactions of oxabicyclic alkenes with secondary amine nucleophiles.
Iridium-catalyzed asymmetric ring-opening reactions of oxabicyclic alkenes with various aliphatic and aromatic secondary amines are reported for the first time. The reaction gave the corresponding trans-1,2-dihydronaphthalenol derivatives in good yields with moderate enantioselectivities in the presence of 2.5 mol % [Ir(COD)Cl](2) and 5 mol % bisphosphine ligand (S)-p-Tol-BINAP. The trans-configuration of 3f was confirmed by X-ray crystallography.
Yang
Dingqiao
D
School of Chemistry and Environment, South China Normal University, Guangzhou 510006, People's Republic of China. yangdq@scnu.edu.cn
Hu
Ping
P
Long
Yuhua
Y
Wu
Yujuan
Y
Zeng
Heping
H
Wang
Hui
H
Zuo
Xiongjun
X