Inadequacies of absolute threshold levels for diagnosing prediabetes.
Prediabetes comprising Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT) represents an intermediate stage of altered glucose metabolism between normal glucose levels and type 2 diabetes mellitus and is associated with an increased risk for the development of diabetes and cardiovascular disease. There is considerable evidence that glucose levels lower than those meeting the current definition of prediabetes may also be associated with similar risks particularly in high-risk individuals. Prediabetes is often unrecognized and therefore constitutes a major public health concern suggesting the need for earlier intervention than is currently recommended.
Bergman
Michael
M
NYU School of Medicine, Division of Endocrinology, NYU Diabetes and Endocrine Associates, 345 East 37th Street, New York, NY 10016, USA. michael.bergman@med.nyu.edu
D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000175:diagnosis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D003925:Diabetic Angiopathies / Q000453:epidemiology; D018149:Glucose Intolerance / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D011236:Prediabetic State / Q000150:complications / Q000175:diagnosis*; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity
D001786:Blood Glucose