Influenza surveillance in a cohort of HIV-infected children and adolescents immunized against seasonal influenza.
During the 2006-2007 season, 19 HIV-uninfected and 33 HIV-infected children and adolescents with full immunovirologic response to HAART were immunized against influenza and subsequently followed up. One month post-immunization all subjects had protective antibodies titres which persisted for the whole influenza season. Seven vaccinees (four HIV-infected and three HIV-uninfected) were found to be infected by influenza viruses during the epidemic, but disease was lab-confirmed only in two HIV-infected subjects. Both presented a benign clinical course and were infected by an A/Brisbane/10/07-H3N2-like virus. These data indicate that HIV-infected subjects benefit from routine seasonal influenza vaccination.
Amendola
Antonella
A
Università degli Studi di Milano, Dipartimento di Sanità Pubblica-Microbiologia-Virologia, Via Pascal 36, 20133 Milan, Italy. antonella.amendola@unimi.it
Pariani
Elena
E
Viganò
Alessandra
A
Erba
Paola
P
Zappa
Alessandra
A
Giacomet
Vania
V
Tanzi
Elisabetta
E
Zuccotti
Gian Vincenzo
GV
Zanetti
Alessandro
A
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D015994:Incidence; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology* / Q000517:prevention & control*; D008297:Male; D016896:Treatment Outcome
D000914:Antibodies, Viral; D007252:Influenza Vaccines