title: Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet.
abstract: The bioavailability and urinary excretion of three dietary flavonoids, quercetin, hesperetin and naringenin, were investigated. Ten healthy men were asked to consume a 'juice mix' containing equal amounts of the three flavonoids, and their urine and plasma samples were collected. The resulting mean plasma area under the curve (AUC)(0-48 h) and C(max) values for quercetin and hesperetin were similar, whereas the AUC(0-48 h) of naringenin and, thus, the relative bioavailability were higher after consumption of the same dose. The study consolidates a significantly lower urinary excretion of quercetin (1.5+/-1%) compared with hesperetin (14.2+/-9.1%) and naringenin (22.6+/-11.5%) and shows that this is not due to a lower bioavailability of quercetin, but rather reflects different clearance mechanisms.
authors.affiliation: The National Food Institute, Technical University of Denmark, Søborg, Denmark. kskr@food.dtu.dk
authors.forename: K S
authors.initials: KS
authors.lastname: Krogholm
authors.forename: L
authors.initials: L
authors.lastname: Bredsdorff
authors.forename: P
authors.initials: P
authors.lastname: Knuthsen
authors.forename: J
authors.initials: J
authors.lastname: Haraldsdóttir
authors.forename: S E
authors.initials: SE
authors.lastname: Rasmussen
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001682:Biological Availability; D004032:Diet; D044950:Flavanones / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006569:Hesperidin / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006801:Humans; D008297:Male; D011794:Quercetin / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D055815:Young Adult
chemical_list: D044950:Flavanones; D011794:Quercetin; D006569:Hesperidin; C005273:naringenin; C013015:hesperetin