Cancer chemoprevention locks onto a new polyamine metabolic target.
Ornithine decarboxylase has a relatively long history as a target for cancer chemoprevention and chemotherapy. Plym Forshell et al. report new evidence (beginning on p. 140 in this issue of the journal) indicating that spermidine synthase, a fellow enzyme of ornithine decarboxylase in polyamine metabolism, is transactivated in part by the MYC gene and is a potential target for chemoprevention of B-cell lymphomas.
Gerner
Eugene W
EW
Arizona Cancer Center and Department of Cell Biology and Anatomy, The University of Arizona, Tucson, USA. egerner@azcc.arizona.edu
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism* / Q000494:pharmacology*; D018890:Chemoprevention / Q000379:methods; D006801:Humans; D016393:Lymphoma, B-Cell / Q000201:enzymology / Q000517:prevention & control*; D011436:Spermidine Synthase / Q000378:metabolism* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D011436:Spermidine Synthase