Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists.
As genome-wide association studies of breast cancer are replicating findings and refinement studies are narrowing the signal location, additional efforts are necessary to elucidate the underlying functional relationships. One approach is to evaluate variation in risk by genotype based on known breast carcinogens, such as ionizing radiation. Given the public health concerns associated with recent increases in medical radiation exposure, this approach may also identify potentially susceptible subpopulations. We examined interaction between 27 newly identified breast cancer risk alleles (identified within the NCI Cancer Genetic Markers of Susceptibility and the Breast Cancer Association Consortium genome-wide association studies) and occupational and medical diagnostic radiation exposure among 859 cases and 1083 controls nested within the United States Radiologic Technologists cohort. We did not find significant variation in the radiation-related breast cancer risk for the variant in RAD51L1 (rs10483813) on 14q24.1 as we had hypothesized. In exploratory analyses, we found that the radiation-associated breast cancer risk varied significantly by linked markers in 5p12 (rs930395, rs10941679, rs2067980 and rs4415084) in the mitochondrial ribosomal protein S30 (MRPS30) gene (P(interaction) = 0.04). Chance, however, may explain these findings, and as such, these results need to be confirmed in other populations with low to moderate levels of radiation exposure. Even though a complete understanding of the way(s) in which these variants may increase breast cancer risk remains elusive, this approach may yield clues for further investigation.
Bhatti
Parveen
P
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. pbhatti@fhcrc.org
Doody
Michele M
MM
Rajaraman
Preetha
P
Alexander
Bruce H
BH
Yeager
Meredith
M
Hutchinson
Amy
A
Burdette
Laurie
L
Thomas
Gilles
G
Hunter
David J
DJ
Simon
Steven L
SL
Weinstock
Robert M
RM
Rosenstein
Marvin
M
Stovall
Marilyn
M
Preston
Dale L
DL
Linet
Martha S
MS
Hoover
Robert N
RN
Chanock
Stephen J
SJ
Sigurdson
Alice J
AJ
D000483:Alleles; D000488:Allied Health Personnel; D001943:Breast Neoplasms / Q000235:genetics* / Q000532:radiotherapy; D016022:Case-Control Studies; D002883:Chromosomes, Human, Pair 14; D002895:Chromosomes, Human, Pair 5; D015331:Cohort Studies; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011839:Radiation, Ionizing; D013679:Technology, Radiologic; D014481:United States; D000078329:Workforce
D004268:DNA-Binding Proteins; C413002:RAD51B protein, human