title: Deletion variant of alpha2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance.
abstract: The COMT val(158) variant has been associated with impaired cognitive function compared to the met(158) variant yet gene-gene interactions are not well described. In this study we demonstrate an interaction between this COMT polymorphism and a deletion variant of ADRA2B, the gene encoding the alpha2b-adrenergic receptor on episodic memory performance. Specifically, carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val(158) carriers compared to met(158) carriers.
authors.affiliation: Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King's College London, United Kingdom. a.gibbs@iop.kcl.ac.uk
authors.forename: Ayana A
authors.initials: AA
authors.lastname: Gibbs
authors.forename: Kris H
authors.initials: KH
authors.lastname: Naudts
authors.forename: Ruben T
authors.initials: RT
authors.lastname: Azevedo
authors.forename: Anthony S
authors.initials: AS
authors.lastname: David
mesh_terms: D000293:Adolescent; D000328:Adult; D002394:Catechol O-Methyltransferase / Q000235:genetics / Q000502:physiology*; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D011110:Polymorphism, Genetic / Q000502:physiology; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics / Q000502:physiology*
chemical_list: C547771:ADRA2B protein, human; D018341:Receptors, Adrenergic, alpha-2; D002394:Catechol O-Methyltransferase