Puerarin exhibits weak estrogenic activity in female rats.
A weak estrogenicity of puerarin on reproductive organs was addressed in female rats. In short-term treatment, immature ovariectomized rats were injected with 0.7 mg/kg BW/day of puerarin, for 14 days. Puerarin did not increase uterus weights, endometrium and myometrium areas, and the percent of cornified cells (%Co), but it increased the number of uterine glands. In long-term treatment, mature rats were injected with 7.0mg/kg BW/day of puerarin for 140 days. Puerarin did not increase uterus weights, endometrium and myometrium areas, and the number of uterine glands, but a significant increase in the %Co was observed from day 98 onwards.
Malaivijitnond
Suchinda
S
Primate Research Unit, Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Suchinda.m@chula.ac.th
Tungmunnithum
Duangjai
D
Gittarasanee
Sarocha
S
Kawin
Kanya
K
Limjunyawong
Nathachit
N
D000367:Age Factors; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D007529:Isoflavones / Q000008:administration & dosage*; D010052:Ovariectomy; D029908:Pueraria; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000187:drug effects*; D014621:Vagina / Q000187:drug effects*
D004967:Estrogens; D007529:Isoflavones; C033607:puerarin