TERC telomerase subunit gene copy number in different disease stages of non-hodgkin lymphoma and in hepatitis C.
ABSTRACT Focal amplification of specific regions of the genome creates high copy number and expression of oncogenes in tumors. By applying fluorescence in situ hybridization (FISH) to leukocytes of hepatitis C (HCV) patients and non-Hodgkin lymphoma (NHL) patients, we estimated gene dosage of the TERC gene at 3q26.3. Higher TERC copy numbers were found in NHL at diagnosis compared to HCV patient groups. Higher TERC copy numbers were also observed in NHL patient at diagnosis and relapse compared to patients in remission. We believe that the TERC gene amplification is involved in the process of genetic instability leading to tumor genesis such as in NHL.
Goldberg-Bittman
L
L
Genetic Institute, Meir Hospital, Kfar Saba 44281, Israel.
Kitay-Cohen
Y
Y
Fejgin
M D
MD
Hadary
R
R
Quitt
M
M
Amiel
A
A
D000368:Aged; D002893:Chromosomes, Human, Pair 3; D018628:Gene Dosage; D006526:Hepatitis C / Q000235:genetics*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D008875:Middle Aged; D012313:RNA / Q000235:genetics*; D019098:Telomerase / Q000235:genetics*
C422952:telomerase RNA; D012313:RNA; D019098:Telomerase