title: Future therapeutic directions for the treatment of psoriasis.
abstract: The future management of psoriasis will depend on a number of distinct but ultimately inter-related strands of evidence, these are: (i) the interplay of genes and environment and the characterisation of psoriasis phenotypes; (ii) the role of pharmacogenetics in personalised healthcare; (iii) the translation of basic scientific discovery of relevant immune and angiogenic pathways into targeted biologic and small molecule therapies; and (iv) the recognition that the management of any chronic disease is enhanced by an understanding of psychosocial issues. A reductionist approach to development of new therapies will be paramount but serendipity and the prepared mind will contribute, as they have always done.
authors.affiliation: Dermatological Sciences, Salford Royal Hospital, University of Manchester, Manchester Academic Health Science Centre, Manchester, M6 8HD, UK.
authors.forename: R B
authors.initials: RB
authors.lastname: Warren
authors.forename: C E M
authors.initials: CE
authors.lastname: Griffiths
mesh_terms: D005544:Forecasting; D006801:Humans; D010597:Pharmacogenetics; D011565:Psoriasis / Q000188:drug therapy*