title: FXYD3 expression in gliomas and its clinicopathological significance.
abstract: FXYD3, interacting with Na+/K+-ATPase, is considered a cell surface regulator modulating the function of ion pumps and ion channels. The FXYD3 gene was originally cloned from murine mammary tumors and then from human breast tumors. However, no study of FXYD3 has been carried out in gliomas; therefore, we examined FXYD3 expression in gliomas and its clinicopathological significance. FXYD3 expression was immunohistochemically examined in 71 primary gliomas, along with 37 matched adjacent normal brain samples and 8 recurred gliomas. The frequency of strong FXYD3 expression was higher in the primary tumors in either unmatched (p = 0.046) or matched cases (p = 0.02), compared to normal brain tissue. FXYD3 expression was significantly more increased in females than males (p = 0.01), and in multiple site gliomas than single sites (p = 0.02). There was no difference of FXYD3 expression regarding age, tumor location, size, histological type, and tumor grade (p > 0.05). The results suggest that FXYD3 expression may be involved in glioma development, especially in multiple gliomas and female patients.
authors.affiliation: Department of Neurology, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Gu
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Zhen-Long
authors.initials: ZL
authors.lastname: Zhu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Geng
authors.forename: Hany
authors.initials: H
authors.lastname: Kayed
authors.forename: Hanswalter
authors.initials: H
authors.lastname: Zentgraf
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D011379:Prognosis; D055815:Young Adult
chemical_list: C091777:FXYD3 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins