title: [High-grade cervical intraepithelial neoplasia during pregnancy: experience in a service in southern Brazil].
abstract: OBJECTIVE
  to evaluate the results of treatment to which patients with high grade intraepithelial cervical neoplasia (HSIL) are submitted, as well as their follow-up during pregnancy.
  
  
  METHODS
  retrospective study based on the review of the medical report of 30 patients with diagnosis of high-grade squamous intraepithelial lesions (HSIL) during pregnancy and attended to at a tertiary hospital in southern Brazil from 1990 to 2002. Diagnosis was performed by colposcopy and biopsy, with repetition of the colposcopy during the pregnancy and after delivery. The diagnoses of regression and progression of lesions were evaluated.
  
  
  RESULTS
  from 30 patients, 3 were excluded of the sample because the diagnosis of high-grade squamous intraepithelial lesions (HSIL) was not confirmed by the colposcopy with biopsia. Four patients were submitted to treatment during pregnancy, and one of them presented preterm delivery at the 32nd week. Twenty-three patients were submitted to expectant treatment, underwent a new colposcopy and biopsy, and then were submitted to conisation surgery at about the 11(th) week after the end of pregnancy. In 7.4% of the cases, there was lesion regression in the surgical specimen.
  
  
  CONCLUSIONS
  all patients with diagnosis should be submitted to colposcopy and biopsy to exclude the possibility of invasive lesion. The expectant procedure for intraepithelial lesions is the most widely chosen and safe due to the possibility of regression in the postpartum period.
authors.affiliation: Hospital Erasto Gaertner, Curitiba, PR, Brasil. vbpreti@yahoo.com.br
authors.forename: Vinícius Basso
authors.initials: VB
authors.lastname: Preti
authors.forename: Sérgio Bruno Bonatto
authors.initials: SB
authors.lastname: Hatschbach
authors.forename: José Clemente
authors.initials: JC
authors.lastname: Linhares
authors.forename: João Antônio
authors.initials: JA
authors.lastname: Guerreiro
authors.forename: Claudiane Lígia
authors.initials: CL
authors.lastname: Minari
authors.forename: Carlos Afonso
authors.initials: CA
authors.lastname: Maestri
authors.forename: Fernanda Villar
authors.initials: FV
authors.lastname: Fonseca
mesh_terms: D000328:Adult; D001938:Brazil; D005260:Female; D006801:Humans; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000628:therapy*