Pathogenic involvement of neuropeptides in anxiety and depression.
Anxiety and depression are highly prevalent disorders of mood posing significant challenges to individuals and society. Current evidence indicates no single neurobiological determinant underpins these conditions and an integrated approach in both research and treatment is expedient. Basic, behavioral, and clinical science indicates various stress-responsive neuropeptides in the neuroendocrine, autonomic, and behavioral pathophysiology of stress-related disorders including anxiety and depression. This review draws on recent research to capture the consensus and implications of neuropeptide research concerning the pathogenesis of anxiety and depression.
Alldredge
Brett
B
Kansas City University of Medicine and Bioscience, College of Medicine, 1705 Independence Ave., Kansas City, United States. balldredge@kcumb.edu
D000223:Adaptation, Psychological; D000818:Animals; D001008:Anxiety Disorders / Q000378:metabolism*; D003866:Depressive Disorder / Q000378:metabolism*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D051379:Mice; D009479:Neuropeptides / Q000378:metabolism*; D051381:Rats; D013313:Stress Disorders, Post-Traumatic / Q000378:metabolism; D013315:Stress, Psychological / Q000378:metabolism
D009479:Neuropeptides