title: [Chemotherapy with low-dose docetaxel and estramustine phosphate in patient with liver dysfunction due to liver metastases of hormone-refractory prostate cancer : a case report].
abstract: A 82-year-old man was referred to our hospital for treatment of hormone-refractory prostate cancer with liver metastases. The obstruction of intrahepatic bile ducts due to the rapid growth of liver metastases induced liver dysfunction. We administered 25 mg/m(2) docetaxel on day1 and 280 mg/body estramustine phosphate on day 1 to day 3, every 4 weeks. After two courses of this combined chemothrapy, the liver metastases were markedly reduced in size with the rapid improvement of liver function.
authors.affiliation: The Department of Urology, Yokohama City University Graduate School of Medicine.
authors.forename: Miki
authors.initials: M
authors.lastname: Miyake
authors.forename: Noboru
authors.initials: N
authors.lastname: Nakaigawa
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kita
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yanagisawa
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Terao
authors.forename: Futoshi
authors.initials: F
authors.lastname: Sano
authors.forename: Takayuki
authors.initials: T
authors.lastname: Murakami
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Makiyama
authors.forename: Takehiko
authors.initials: T
authors.lastname: Ogawa
authors.forename: Hiroji
authors.initials: H
authors.lastname: Uemura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yao
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kubota
mesh_terms: D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000077143:Docetaxel; D004961:Estramustine / Q000008:administration & dosage; D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy / Q000209:etiology; D008113:Liver Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D043823:Taxoids; D000077143:Docetaxel; D004961:Estramustine