[Correlation of serum chemokine RANTES level with serum biochemical indices, HBeAg and HBV DNA load in patients with chronic hepatitis B].
OBJECTIVE
To investigate the level of the serum chemokine RANTES and its correlation with serum biochemical indices of liver function test, HBeAg and HBV DNA load in patients with chronic hepatitis B.


METHODS
144 patients with chronic hepatitis B (observed group) and 18 normal cases (control group) were enrolled in this study. The serum level of chemokine RANTES was detected with an ABC-ELISA assay. Statistical analysis was performed on the software of SPSS13.0.


RESULTS
The serum chemokine RANTES level in the observed group (3930.12 ng/ml 2856.96) ng/ml was significantly higher than that in the control group (329.46 ng/ml +/- 152.23) ng/ml. The results from the observed group indicated the positive correlation of serum RANTES level with indices of liver function test, including ALT (r = 0.197, P = 0.018), AST(r = 0.239, P = 0.004) and TBil (r = 0.316, P = 0.001), but did not with PTA (r = - 0.078, P = 0.357). Neither difference of serum chemokine RANTES level between HBeAg-positive group and HBeAg-negative group nor that between high HBV DNA load group (> or = 10(5) copies/ml) and low HBV DNA load group (< 10(5) copies/ml) were statistically significant (P = 0.407 and 0.185, respectively).


CONCLUSIONS
Serum chemokine RANTES level in patients with chronic hepatitis B elevates significantly and is not affected by HBeAg or HBV DNA load. Its positive correlation with indices of liver function test indicates that RANTES might play an important role in the pathogenesis of chronic hepatitis B.
Zhang
Ka
K
Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Xu
Qi-Huan
QH
Chen
Lu-Biao
LB
Shu
Xin
X
Chen
Ni
N
Li
Gang
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000097:blood*; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006513:Hepatitis B e Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000302:isolation & purification / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000097:blood / Q000175:diagnosis* / Q000821:virology; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D019562:Viral Load; D055815:Young Adult
D018946:Chemokine CCL5; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens