Self-activated luminescent and mesoporous strontium hydroxyapatite nanorods for drug delivery.
Multifunctional strontium hydroxyapatite (SrHAp) nanorods with luminescent and mesoporous properties have been successfully synthesized by a hydrothermal method. SEM and TEM images indicate that the mesoporous SrHAp samples consist of monodiperse nanorods with lengths of 120-150 nm, diameters of around 20 nm, and the mesopore size of 3-5 nm. The as-obtained SrHAp nanorods show an intense bright blue emission (centered at 432 nm, lifetime 11.6 ns, quantum efficiency: 22%), which might arise from CO(2)(*-) radical impurities in the crystal lattice under long-wavelength UV-light irradiation. Furthermore, the amount of trisodium citrate has an obvious impact on the particle size and the luminescence properties of the products, respectively. The drug storage/release test indicates that the luminescent SrHAp nanorods show a drug loading and controlled release properties for ibuprofen (IBU). Additionally, the emission intensity of SrHAp in the drug carrier system increases with the cumulative released amount of IBU, making the drug release might be easily tracked and monitored by the change of the luminescence intensity. This luminescent material may be potentially applied in the drug delivery and disease therapy fields.
Zhang
Cuimiao
C
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, PR China.
Li
Chunxia
C
Huang
Shanshan
S
Hou
Zhiyao
Z
Cheng
Ziyong
Z
Yang
Piaoping
P
Peng
Chong
C
Lin
Jun
J
D016503:Drug Delivery Systems; D006882:Hydroxyapatites / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes; D013324:Strontium / Q000737:chemistry*; D014466:Ultraviolet Rays; D014961:X-Ray Diffraction
D006882:Hydroxyapatites; C076185:strontium hydroxyapatite; D013324:Strontium