Anti-HSV-1 activity and mechanism of action of some new synthesized substituted pyrimidine, thiopyrimidine and thiazolopyrimidine derivatives.
A series of heterocyclic derivatives 2-16 conjugated with tetrahydronaphthalene moiety were synthesized as antiviral agents by using 1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanone as starting material. The antiviral screening showed that many of these obtained compounds have good antiviral activities comparable to Acyclovir as reference control. Two compounds 13 and 15 gave over 90% inhibition and considered to be highly promising and on confirming their activity and comparing them to antiviral activity of Acyclovir. The detailed synthesis, spectroscopic data, and antiviral screening for synthesized compounds were reported.
Mohamed
Salwa F
SF
Applied Organic Chemistry Dept., National Research Center, Dokki, Cairo, Egypt.
Flefel
Eman M
EM
Amr
Abd El-Galil E
Ael-G
Abd El-Shafy
Dina N
DN
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000502:physiology; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D011743:Pyrimidines