Cohesin and Cdk1: an anaphase barricade.
Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters requires the associated loss in Cdk1 activity. Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated.
Jones
Keith T
KT
School of Biomedical Sciences, Faculty of Health, University of Newcastle, NSW 2308, Australia. keith.jones@newcastle.edu.au
D000705:Anaphase / Q000235:genetics / Q000502:physiology*; D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002842:Chromatids / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism; D000097722:Cohesins
D064173:Anaphase-Promoting Complex-Cyclosome; D016203:CDC2 Protein Kinase; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D043743:Ubiquitin-Protein Ligase Complexes; D000097722:Cohesins