[Lentinan induces the expression of human-beta-defensin-2 in pulmonary epithelial cells].
To determine whether lentinan could upregulate the expression of human-beta-defensin-2(HBD-2) in pulmonary epithelial cells (SPC-A-1), we stimulated pulmonary epithelial cells with lentinan and detected the expression of HBD-2mRNA by RT-PCR test. The results demonstrated that the expression of HBD-2mRNA in SPC-A-1 could be induced by lentinan in a concentration and time-dependent manner.
Zhou
Yan
Y
Department of Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.
Dong
Birong
B
Teng
Lihua
L
Wang
Hui
H
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D007912:Lentinan / Q000494:pharmacology*; D008168:Lung / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D023083:beta-Defensins / Q000235:genetics / Q000378:metabolism*
D000276:Adjuvants, Immunologic; C106641:DEFB4A protein, human; D012333:RNA, Messenger; D023083:beta-Defensins; D007912:Lentinan