title: Tract-specific and region of interest analysis of corticospinal tract integrity in subcortical ischemic stroke: reliability and correlation with motor function of affected lower extremity.
abstract: OBJECTIVE
  TS analysis has been suggested as a useful method to evaluate the fiber integrity of white matter tracts. This study investigated the intrarater and interrater reliability and validity of a TS analysis for the CST and compared the results with those of a ROI-based analysis.
  
  
  METHODS
  Diffusion spectrum imaging was performed on 7 patients with subcortical ischemic stroke on a 3T MR imaging system. For the TS analysis, seed regions were placed at the cerebral peduncle and the medial portion of the primary motor cortex to reconstruct the tracts of the CST for motor control of the lower extremity. The mean GFA was measured at the PLIC by calculating the weighted sum of the GFAs sampled by the CST tracts at this segment. For the ROI-based analysis, the posterior two-thirds of the PLIC were enclosed on the GFA maps, and the mean GFA in this ROI was calculated.
  
  
  RESULTS
  The results showed good-to-excellent intrarater and interrater reliability on the seed region/ROI placement (mean kappa values >0.80) and mean GFA values (ICCs >0.90) for both the TS and ROI-based analyses. Both the GFA(PLIC-TS) and GFA(PLIC-ROI) values were highly correlated with the motor function of the affected lower extremity (r = 0.76 and 0.80, respectively; P < .05).
  
  
  CONCLUSIONS
  We demonstrated good reliability and validity of the TS and ROI-based analyses of the CST corresponding to lower extremity motor control in patients with subcortical ischemic stroke.
authors.affiliation: School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, No. 1 Jen-Ai Road, Taipei, Taiwan, Republic of China.
authors.forename: P-F
authors.initials: PF
authors.lastname: Tang
authors.forename: Y-H
authors.initials: YH
authors.lastname: Ko
authors.forename: Z-A
authors.initials: ZA
authors.lastname: Luo
authors.forename: F-C
authors.initials: FC
authors.lastname: Yeh
authors.forename: S-H A
authors.initials: SH
authors.lastname: Chen
authors.forename: W-Y I
authors.initials: WY
authors.lastname: Tseng
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000473:pathology* / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods / Q000592:standards* / Q000706:statistics & numerical data; D004525:Efferent Pathways / Q000473:pathology* / Q000502:physiology; D005260:Female; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D015588:Observer Variation; D011712:Pyramidal Tracts / Q000473:pathology* / Q000503:physiopathology; D016059:Range of Motion, Articular / Q000502:physiology; D020127:Recovery of Function; D015203:Reproducibility of Results; D020521:Stroke / Q000473:pathology* / Q000503:physiopathology