title: FES kinase participates in KIT-ligand induced chemotaxis.
abstract: FES is a cytoplasmic tyrosine kinase activated by several membrane receptors, originally identified as a viral oncogene product. We have recently identified FES as a crucial effector of oncogenic KIT mutant receptor. However, FES implication in wild-type KIT receptor function was not addressed. We report here that FES interacts with KIT and is phosphorylated following activation by its ligand SCF. Unlike in the context of oncogenic KIT mutant, FES is not involved in wild-type KIT proliferation signal, or in cell adhesion. Instead, FES is required for SCF-induced chemotaxis. In conclusion, FES kinase is a mediator of wild-type KIT signalling implicated in cell migration.
authors.affiliation: INSERM U891, Centre de Recherche en Cancérologie de Marseille (CRCM), Marseille, France. Edwige.Voisset@inserm.fr
authors.forename: Edwige
authors.initials: E
authors.lastname: Voisset
authors.forename: Sophie
authors.initials: S
authors.lastname: Lopez
authors.forename: Amandine
authors.initials: A
authors.lastname: Chaix
authors.forename: Marina
authors.initials: M
authors.lastname: Vita
authors.forename: Coralie
authors.initials: C
authors.lastname: George
authors.forename: Patrice
authors.initials: P
authors.lastname: Dubreuil
authors.forename: Paulo
authors.initials: P
authors.lastname: De Sepulveda
mesh_terms: D002448:Cell Adhesion; D045744:Cell Line, Tumor; D002633:Chemotaxis; D006801:Humans; D010766:Phosphorylation; D051578:Proto-Oncogene Proteins c-fes / Q000235:genetics / Q000378:metabolism*; D019089:Stem Cell Factor / Q000378:metabolism*; D020798:Two-Hybrid System Techniques; D014443:Tyrosine; D018909:src Homology Domains
chemical_list: D019089:Stem Cell Factor; D014443:Tyrosine; D051578:Proto-Oncogene Proteins c-fes