Molecular mechanisms underlying PGF2alpha-induced hypertrophy of vascular smooth muscle cells.
The present review focuses primarily on the studies we made in recent years to improve the understanding of the molecular mechanisms of PGF2alpha-induced hypertrophy of Vascular Smooth Muscle Cells (VSMC). In this review, we will summarize the recent findings in the context of the PGF2alpha signaling pathway in three parts: PGF2alpha binding to its receptor, transactivation of EGF receptor, two independent signaling transduction pathways increasing the expression of NOX1 gene.
Fan
Chunyuan
C
Department of Nephrology, West China Hospital, Sichuan University, Chengdu, China. fanchunyuan38@yahoo.com.cn
Katsuyama
Masato
M
Wei
Haiyan
H
Xia
Qingjie
Q
Liu
Wentao
W
Yabe-Nishimura
Chihiro
C
D051697:Activating Transcription Factor 1 / Q000502:physiology; D000818:Animals; D015237:Dinoprost / Q000378:metabolism / Q000502:physiology*; D066246:ErbB Receptors / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D006984:Hypertrophy; D026161:MADS Domain Proteins / Q000502:physiology; D064326:MEF2 Transcription Factors; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000473:pathology*; D018006:Myogenic Regulatory Factors / Q000502:physiology; D000074624:NADPH Oxidase 1; D019255:NADPH Oxidases / Q000235:genetics; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D051745:Protein Kinase C-delta / Q000502:physiology; D011982:Receptors, Prostaglandin / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013481:Superoxides / Q000378:metabolism; D015533:Transcriptional Activation; D015854:Up-Regulation; D019061:src-Family Kinases / Q000502:physiology
D051697:Activating Transcription Factor 1; D026161:MADS Domain Proteins; D064326:MEF2 Transcription Factors; C578038:MEF2B protein, human; D018006:Myogenic Regulatory Factors; D011982:Receptors, Prostaglandin; C034671:prostaglandin F2alpha receptor; D013481:Superoxides; D015237:Dinoprost; D000074624:NADPH Oxidase 1; D019255:NADPH Oxidases; C402799:NOX1 protein, human; D019869:Phosphatidylinositol 3-Kinases; D066246:ErbB Receptors; D019061:src-Family Kinases; D051745:Protein Kinase C-delta