title: Markedly different cytotoxicity of the two enantiomers of C(2)-symmetrical Ti(IV) phenolato complexes; mechanistic implications.
abstract: The two enantiomers of a member of the highly active C(2)-symmetrical bis(isopropoxo) Ti(iv) family of complexes of diamine bis(phenolato) ligands demonstrate markedly different cytotoxicity, supporting a chiral biological target of activity and participation of a ligand-bound active species.
authors.affiliation: Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
authors.forename: Cesar M
authors.initials: CM
authors.lastname: Manna
authors.forename: Edit Y
authors.initials: EY
authors.lastname: Tshuva
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D018360:Crystallography, X-Ray; D003959:Diamines / Q000737:chemistry; D019073:HT29 Cells; D006801:Humans; D008968:Molecular Conformation; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D003959:Diamines; D014025:Titanium