title: Possible expressions of radiation-induced genomic instability, bystander effects or low-dose hypersensitivity in cancer epidemiology.
abstract: Recent publications on the integration of radiobiological effects in the two-step clonal expansion (TSCE) model of carcinogenesis and applications to radioepidemiological data are reviewed and updated. First, a model version with radiation-induced genomic instability was shown to be a possible explanation for the age dependence of the radiation-induced cancer mortality in the Techa River Cohort. Second, it is demonstrated that inclusion of a bystander effect with a dose threshold allows an improved description of the lung cancer mortality risk for the Mayak workers cohort due to incorporation of plutonium. The threshold for the annual lung dose is estimated to 12 (90%CI: 4; 14)mGy/year. This threshold applies to the initiation of preneoplastic cells and to hyperplastic growth. There is, however, no evidence for a threshold for the effects of gamma radiation. Third, models with radiation-induced cell inactivation tend to predict lower cancer risks among the atomic bomb survivors with exposure at young age than conventionally used empirical models. Also, risks after exposures with doses in the order of 100mGy are predicted to be higher in models with low-dose hypersensitivity than in models with conventional cell survival curves. In the reviewed literature, models of carcinogenesis tend to describe radioepidemiological data better than conventionally used empirical models.
authors.affiliation: Helmholtz Zentrum München, Institute of Radiation Protection, 85764 Neuherberg, Germany. Electronic address: Jacob@helmholtz-muenchen.de.
authors.forename: Peter
authors.initials: P
authors.lastname: Jacob
authors.affiliation: Helmholtz Zentrum München, Institute of Radiation Protection, 85764 Neuherberg, Germany.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Meckbach
authors.affiliation: Helmholtz Zentrum München, Institute of Radiation Protection, 85764 Neuherberg, Germany.
authors.forename: Jan Christian
authors.initials: JC
authors.lastname: Kaiser
authors.affiliation: Southern Urals Biophysics Institute, Ozyorsk 456780, Russia.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Sokolnikov
mesh_terms: D024201:Bystander Effect; D004307:Dose-Response Relationship, Radiation; D042822:Genomic Instability; D006801:Humans; D007564:Japan; D008175:Lung Neoplasms / Q000453:epidemiology; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D016273:Occupational Exposure; D011836:Radiation Tolerance; D012306:Risk; D012426:Russia; D014875:Water Pollutants, Radioactive
chemical_list: D014875:Water Pollutants, Radioactive