title: Functional characterisation of sensory ERPs using probabilistic ICA: effect of stimulus modality and stimulus location.
abstract: OBJECTIVE
  To decompose sensory event-related brain potentials (ERPs) into a set of independent components according to the modality and the spatial location of the eliciting sensory stimulus, and thus provide a quantitative analysis of their underlying components.
  
  
  METHODS
  Auditory, somatosensory and visual ERPs were recorded from 124 electrodes in thirteen healthy participants. Probabilistic Independent Component Analysis (P-ICA) was used to decompose these sensory ERPs into a set of independent components according to the modality (auditory, somatosensory, visual or multimodal) and the spatial location (left or right side) of the eliciting stimulus.
  
  
  RESULTS
  Middle-latency sensory ERPs were explained by a large contribution of multimodal neural activities, and a smaller contribution of unimodal neural activities. While a significant fraction of unimodal neural activities were dependent on the location of the eliciting stimulus, virtually all multimodal neural activities were not (i.e. their scalp distributions and time courses were not different when stimuli were presented on the left and right sides).
  
  
  CONCLUSIONS
  These findings show that P-ICA can be used to dissect effectively sensory ERPs into physiologically meaningful components, and indicate a new approach for exploring the effect of various experimental modulations of sensory ERPs.
  
  
  CONCLUSIONS
  This approach offers a better understanding of the functional significance of sensory ERPs.
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford, UK.
authors.forename: M
authors.initials: M
authors.lastname: Liang
authors.forename: A
authors.initials: A
authors.lastname: Mouraux
authors.forename: V
authors.initials: V
authors.lastname: Chan
authors.forename: C
authors.initials: C
authors.lastname: Blakemore
authors.forename: G D
authors.initials: GD
authors.lastname: Iannetti
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D004566:Electrodes; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006225:Hand / Q000294:innervation; D006801:Humans; D008297:Male; D010812:Physical Stimulation / Q000379:methods; D025341:Principal Component Analysis; D011336:Probability; D011930:Reaction Time / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D013028:Space Perception / Q000502:physiology*; D055815:Young Adult