title: Aplasia cutis congenita: three cases with three different underlying etiologies.
abstract: Aplasia cutis congenita (ACC) is an uncommon condition in which localized or widespread areas of skin are absent or scarred at birth. There is no single underlying cause of ACC, as it simply represents a physical finding that reflects a disruption of intrauterine skin development. Here we report three cases of ACC of the scalp with three different etiologies: congenital rubella syndrome, trisomy 13 and fetal valproate syndrome. The aim of the present report is to increase awareness of these skin defects and emphasize the importance of underlying etiologies.
authors.affiliation: Division of Clinical Genetics, Akdeniz University Faculty of Medicine, Antalya, Turkey.
authors.forename: Ercan
authors.initials: E
authors.lastname: Mihçi
authors.forename: Seyhan
authors.initials: S
authors.lastname: Erişir
authors.forename: Sükran
authors.initials: S
authors.lastname: Taçoy
authors.forename: Güven
authors.initials: G
authors.lastname: Lüleci
authors.forename: Erkan
authors.initials: E
authors.lastname: Alpsoy
authors.forename: Nihal
authors.initials: N
authors.lastname: Oygür
mesh_terms: D000014:Abnormalities, Drug-Induced; D000015:Abnormalities, Multiple; D000927:Anticonvulsants / Q000009:adverse effects; D002882:Chromosomes, Human, Pair 13; D004476:Ectodermal Dysplasia / Q000209:etiology / Q000235:genetics; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012410:Rubella Syndrome, Congenital / Q000150:complications; D012535:Scalp / Q000002:abnormalities; D014314:Trisomy; D014635:Valproic Acid / Q000009:adverse effects
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid