Birth weight, family history of diabetes, and metabolic syndrome in children and adolescents.
OBJECTIVE
To evaluate whether a coupled family history of diabetes (FHD) and low birth weight (LBW) or high birth weight (HBW) is associated with metabolic syndrome (MetS) in children and adolescents.


METHODS
A total of 1262 children and adolescents age 7-15 years were randomly selected to enroll in this cross-sectional, community-based study.


RESULTS
In the overall population, HBW (odds ratio [OR] = 1.4; 95% confidence interval [CI] = 1.2-10.9), but not LBW (OR = 0.97; 95% CI = 0.6-2.1), was significantly associated with MetS. In the group without FHD, HBW (OR = 1.730; 95% CI = 1.1-2.7), but not LBW (OR = 1.139; 95% CI = 0.7-23), was associated with MetS. In the group with FHD, both LBW (OR = 2.690; 95% CI = 1.4-15.1) and HBW (OR = 3.289; 95% CI = 1.3-30.6) were associated with MetS. Both LBW (OR = 4.710; 95% CI = 1.4-39.7) and HBW (OR = 3.127; 95% CI = 1.3-45.1) were associated with MetS in children and adolescents with FHD in the maternal branch but not in the paternal branch.


CONCLUSIONS
HBW or LBW, in combination with positive FHD in the maternal branch, are determinants of MetS.
Guerrero-Romero
Fernando
F
Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico.
Aradillas-García
Celia
C
Simental-Mendia
Luis E
LE
Monreal-Escalante
Elizabeth
E
de la Cruz Mendoza
Esperanza
E
Rodríguez-Moran
Martha
M
D000293:Adolescent; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology*; D012307:Risk Factors; D012959:Socioeconomic Factors
D001786:Blood Glucose; D008055:Lipids