Current data and strategy in glioblastoma multiforme.
Glioblastoma multiforme (GBM) or astrocytoma grade IV on WHO classification is the most aggressive and the most frequent of all primary brain tumors. Glioblastoma is multiforme, resistant to therapeutic interventions illustrating the heterogeneity exhibited by this tumor in its every aspect, including clinical presentation, pathology, genetic signature. Current data and treatment strategy in GBM are presented focusing on basic science data and key clinical aspects like surgery, including personal experience; adjuvant modalities: radiotherapy, chemotherapy, but also for experimental approaches. Therapeutic attitude in recurrent GBM is also widely discussed.
Iacob
Gabriel
G
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. gbrl_cb@yahoo.com
Dinca
Eduard B
EB
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D001932:Brain Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D002874:Chromosome Mapping; D003937:Diagnosis, Differential; D066246:ErbB Receptors / Q000235:genetics; D005784:Gene Amplification; D005909:Glioblastoma / Q000188:drug therapy / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D009857:Oncogenes; D051059:PTEN Phosphohydrolase / Q000172:deficiency / Q000235:genetics; D011379:Prognosis; D016019:Survival Analysis; D055815:Young Adult
D066246:ErbB Receptors; D051059:PTEN Phosphohydrolase