Continuous infusion of amphotericin B deoxycholate in the treatment of cryptococcal meningoencephalitis: analysis of safety and fungicidal activity.
We measured fungicidal activity of continuous infusion of amphotericin B deoxycholate plus 5'flucytosine using quantitative cultures of cerebrospinal fluid (CSF) obtained from lumbar punctures of human immunodeficiency virus (HIV)-infected patients with neurocryptococcosis during 14 days of treatment. Glomerular renal function was preserved in all patients. Mycological efficacy with progressive reduction in CSF cryptococcal colony-forming units was comparable to standard 4-h infusion of amphotericin B.
Falci
Diego Rodrigues
DR
Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil.
Lunardi
Luciano Weber
LW
Ramos
Carina Guedes
CG
Bay
Mônica Baumgardt
MB
Aquino
Valério Rodrigues
VR
Goldani
Luciano Zubaran
LZ
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage* / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D002555:Cerebrospinal Fluid / Q000382:microbiology; D015169:Colony Count, Microbial; D003454:Cryptococcus / Q000187:drug effects / Q000302:isolation & purification; D003840:Deoxycholic Acid / Q000008:administration & dosage* / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005437:Flucytosine / Q000008:administration & dosage / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D016919:Meningitis, Cryptococcal / Q000188:drug therapy* / Q000382:microbiology; D050296:Microbial Viability / Q000187:drug effects; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
D000935:Antifungal Agents; D004338:Drug Combinations; D003840:Deoxycholic Acid; D000666:Amphotericin B; C059765:amphotericin B, deoxycholate drug combination; D005437:Flucytosine