An efficient ultrasonic-assisted synthesis of imidazolium and pyridinium salts based on the Zincke reaction.
A mild and efficient method has been developed using ultrasound irradiation for the synthesis of imidazolium and pyridinium salts based on the Zincke reaction. Tertiary nitrogen nucleophiles such as pyridines and imidazoles can be alkylated with primary amine by simply using their ammonium form Zincke salts. In almost all cases, a clear yield increase results and a dramatic reduction of the reaction time accompanied by an improved quality of the products occurs.
Zhao
Sanhu
S
Department of Chemistry, Xinzhou Teachers University, Xinzhou 034000, China. sanhuzhao@yahoo.cn
Xu
Xiaoming
X
Zheng
Lu
L
Liu
Hai
H
D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007700:Kinetics; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D012492:Salts / Q000737:chemistry; D014465:Ultrasonics
D007093:Imidazoles; D011726:Pyridinium Compounds; D012492:Salts; C029899:imidazole