[Seroepidemical study of Coxsackievirus A 16, in four provinces, China, 2005].
OBJECTIVE
To study the situation of 1- 5-years-old children's antibody against Coxsackievirus A group 16 strain (CVA16) in Guangdong, Heilongjiang,Yunnan Province and Xinjiang Uygur Autonomous Regions, China, 2005, it can offer scientific evidences for preventing and controlling CVA16 causative hand-food and mouth disease.


METHODS
Using microneutrilization test, to study 503 serum samples randomly selected from sera collected in 2005.


RESULTS
Positive rate of anti-CVA16 antibody were 41.90%, 9.40%, 40.00% and 34.40% in Guangdong, Heilongjiang,Yunnan and Xinjiang, respectively. Antibody titer was relative low (average, 1: 6.1) and there was no statistical difference of geometry mean of antibody titer (GMT) among Guangdong, Heilongjiang, Yunnan (F = 0.97, 0.40, 1.06, respectively; P > 0.05), while there had statistical difference of GMT between Heilongjiang and other three regions( F = 10.61, P < 0.00).


CONCLUSIONS
There had probably existed local epidemic in some regions of Guangdong, Heilongjiang, Yunnan Province and Xinjiang Uygur Autonomous Regions, China, 2005 or even before, but the area and degree of transmission and epidemic had difference. Children aged from 1- 5-years-old were relatively susceptible population of CVA16 infection.
Yang
Zhao-hui
ZH
Basic Medical School, Lanzhou University, Lanzhou 730000, China.
Zhu
Shuang-li
SL
Zhu
Hui
H
An
Hong-qiu
HQ
Mao
Nai-ying
NY
Ji
Yi-xin
YX
Guo
Xue-bin
XB
Yin
Shao-fu
SF
Zhang
Zong-jiu
ZJ
Xu
Wen-bo
WB
D000914:Antibodies, Viral / Q000097:blood; D002681:China / Q000453:epidemiology; D029821:Enterovirus A, Human / Q000276:immunology* / Q000302:isolation & purification; D004769:Enterovirus Infections / Q000453:epidemiology* / Q000276:immunology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral