title: Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264.
abstract: Bacterial acyl-homoserine lactones upregulated an uncharacterized gene cluster (bta) in Burkholderia thailandensis E264 to produce an uncharacterized polar antibiotic. The antibiotic is identified as a mixture of four bactobolins. Annotation of the bta cluster allows us to propose a biosynthetic scheme for bactobolin and reveals unusual enzymatic reactions for further study.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Seyedsayamdost
authors.forename: Josephine R
authors.initials: JR
authors.lastname: Chandler
authors.forename: Joshua A V
authors.initials: JA
authors.lastname: Blodgett
authors.forename: Patricia S
authors.initials: PS
authors.lastname: Lima
authors.forename: Breck A
authors.initials: BA
authors.lastname: Duerkop
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Oinuma
authors.forename: E Peter
authors.initials: EP
authors.lastname: Greenberg
authors.forename: Jon
authors.initials: J
authors.lastname: Clardy
mesh_terms: D054742:Acyl-Butyrolactones / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D019117:Burkholderia / Q000737:chemistry / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D053038:Quorum Sensing
chemical_list: D054742:Acyl-Butyrolactones; D000900:Anti-Bacterial Agents; D001578:Benzopyrans; C547429:bactobolin D; C025268:bactobolin