Influenza A/H1N1 2009 pneumonia in kidney transplant recipients: characteristics and outcomes following high-dose oseltamivir exposure.
We report 2 cases of severe pneumonia due to the novel pandemic influenza A/H1N1 2009 in kidney transplant recipients. Our patients initially experienced influenza-like illness that rapidly progressed to severe pneumonia within 48 h. The patients became hypoxic and required non-invasive ventilation. The novel influenza A/H1N1 2009 was identified from their nasal swabs. These cases were treated successfully with a relatively high dose of oseltamivir, adjusted for their renal function. Clinical improvement was documented only after a week of antiviral therapy. Despite early antiviral treatment, we showed that morbidity following novel pandemic influenza A/H1N1 2009 infection is high among kidney transplant recipients.
Watcharananan
S P
SP
Department of Infectious Disease, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. orndoctor@yahoo.com
Suwatanapongched
T
T
Wacharawanichkul
P
P
Chantratitaya
W
W
Mavichak
V
V
Mossad
S B
SB
D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000188:drug therapy*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D053139:Oseltamivir / Q000008:administration & dosage / Q000627:therapeutic use*; D011024:Pneumonia, Viral / Q000188:drug therapy*; D011183:Postoperative Complications / Q000188:drug therapy*; D014180:Transplantation; D016896:Treatment Outcome
D000998:Antiviral Agents; D053139:Oseltamivir