A case of insulinoma following total gastrectomy--effects of an alpha-glucosidase inhibitor on suppressing GIP and GLP-1 elevations.
A 61-year-old woman with fasting hypoglycemia following total gastrectomy was diagnosed as insulinoma. GIP and GLP-1 levels after a mixed meal were extremely increased. Administration of miglitol, an alpha-glucosidase inhibitor, suppressed the GIP and GLP-1 elevations.
Sato
Takehiro
T
Department of Endocrinology, Diabetes and Geriatric Medicine, Akita University Graduate School of Medicine, Hondo, Akita, Japan.
Narita
Takuma
T
Hosoba
Mihoko
M
Kakei
Masafumi
M
Nanjo
Hiroshi
H
Uchinami
Hiroshi
H
Satoh
Kohei
K
Yamamoto
Yuzo
Y
Yamada
Yuichiro
Y
D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D005743:Gastrectomy; D005749:Gastric Inhibitory Polypeptide / Q000097:blood*; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000175:diagnosis; D007340:Insulinoma / Q000097:blood / Q000175:diagnosis*; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis*; D019518:Postprandial Period
D065089:Glycoside Hydrolase Inhibitors; C045621:miglitol; D017485:1-Deoxynojirimycin; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1