[Cardiac dyssynchrony correlates with left ventricular remodeling after myocardial Infarction].
BACKGROUND
Cardiac dyssynchrony is common in advanced heart failure (HF), but the changes in cardiac synchrony after myocardial infarction (MI) have not been adequately descríbed.


OBJECTIVE
To study the relationship between cardiac synchrony and left ventricular remodeling after acute myocardial infarction.


METHODS
Forty nine patients aged 59+/-10 years (77% men) with a first episode of a ST segment elevation MI, were studied. Scintigraphic left ventricular function and synchrony analyses were performed at baseline and after a six months follow-up. Determinations were compared with 33 healthy subjects.


RESULTS
At baseline, patients with MIhad a decreased left ventricular ejection fraction (LVEF) and significant dyssynchrony, when compared with controls. LVEF was 36.4%+/-10%, left ventricular end-diastolic volume (LVEDV) 127+/-38 mL, interventricular delay (IEV) 29+/-35 miliseconds (ms), and intraventricular delay (IAV), 234+/-89 ms. After 6 months, LVEF significantly improved (38%+/-10%, p =0.042) without significant changes in LVEDV (129+/-32 mL, p =0.97), IEV (24+/-17, p =0.96) or IAV (231+/-97, p =0.34). At baseline there were significant correlations between IAV and LVEF, and between IAV and LVEDV (r =0.48, p =0.001 and r =0.41, p =0.004, respectively). These correlations remained significant after 6 months. There was a positive correlation between IAV and LVEDV changes at six months (r =0.403, p =0.04).


CONCLUSIONS
The development of cardiac dyssynchrony correlates with adverse left ventricular remodeling after MI .
McNab
Paul
P
Departamento de Enfermedades Cardiovasculares, Pontificia Universidad de Catolica de Chile, Santiago, Chile.
Castro
Pablo
P
Gabrielli
Luigi
L
Verdejo
Hugo
H
Quintana
Juan Carlos
JC
Rodríguez
José A
JA
Corbalán
Ramón
R
D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology; D011877:Radionuclide Imaging; D013318:Stroke Volume / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D020257:Ventricular Remodeling / Q000502:physiology*