title: Novelty-seeking in Parkinson's disease after deep brain stimulation of the subthalamic nucleus: a case-control study.
abstract: BACKGROUND
  The prevalence of psychiatric comorbidity in Parkinson's disease (PD) is about 50%.
  
  
  OBJECTIVE
  The authors investigated differences among PD patients treated by deep brain stimulation (DBS), by drugs alone (noDBS), and healthy control subjects.
  
  
  METHODS
  Samples of 22 subjects in each group were assessed with the Temperament and Character Inventory (TCI) and Hamilton scales for anxiety and depression (Ham-A and Ham-D).
  
  
  RESULTS
  Higher scores emerged on two Novelty-Seeking subscales in PD-DBS patients. Ham-A and Ham-D scores were lower in PD-DBS patients than in PD-noDBS patients and control subjects. Rigidity and non-impulsiveness were lower in PD-DBS than in PD-noDBS patients.
  
  
  CONCLUSIONS
  Further studies should investigate whether or not these changes in personality are a consequence of the motor and depression improvement after DBS.
authors.affiliation: Dept. of Neuroscience, Psychiatric Institute, University of Turin, Via Cherasco Number 11, 10126, Torino, Italy. secondo.fassino@unito.it
authors.forename: Secondo
authors.initials: S
authors.lastname: Fassino
authors.forename: Giovanni
authors.initials: G
authors.lastname: Abbate Daga
authors.forename: Carla
authors.initials: C
authors.lastname: Gramaglia
authors.forename: Andrea
authors.initials: A
authors.lastname: Pierò
authors.forename: Maurizio
authors.initials: M
authors.lastname: Zibetti
authors.forename: Lorys
authors.initials: L
authors.lastname: Castelli
authors.forename: Annina
authors.initials: A
authors.lastname: Cinquepalmi
authors.forename: Michele
authors.initials: M
authors.lastname: La Notte
authors.forename: Leonardo
authors.initials: L
authors.lastname: Lopiano
mesh_terms: D016022:Case-Control Studies; D046690:Deep Brain Stimulation; D005106:Exploratory Behavior; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy*; D015995:Prevalence; D020531:Subthalamic Nucleus / Q000502:physiology*; D011795:Surveys and Questionnaires