Cytomegalovirus resistance testing: pitfalls and problems for the clinician.
In this review, I describe the available assays for detecting resistance of cytomegalovirus (CMV) to antivirals and emphasize the practical utility of the genotypic approach. The indications for such testing and the contraindications are discussed, as are the interpretation of results and the evidence of cross-resistance between antivirals.
Drew
W Lawrence
WL
UCSF Medical Center at Mount Zion, University of California, San Francisco, 94115, USA. lawrence.drew@clinlab.ucsfmedctr.org
D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003587:Cytomegalovirus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000821:virology*; D004279:DNA, Viral / Q000235:genetics; D024882:Drug Resistance, Viral; D005838:Genotype; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods*
D000998:Antiviral Agents; D004279:DNA, Viral