Proteomics in Parkinson's disease: current trends, translational snags and future possibilities.
Proteomic technologies are widely used to understand the molecular mechanism of Parkinson's disease (PD) and to develop biomarkers for its early diagnosis. The differential expression patterns of brain, cerebrospinal fluid and blood proteins of patients or chemically induced animal models are used to identify protein fingerprints for developing diagnostic and therapeutic strategies for PD. A number of differentially expressed proteins associated with energy metabolism, oxidative stress, signal transduction, electron transport and detoxification pathways are identified using proteomic strategies. Proteomics immensely contributed to the detection of qualitative and quantitative changes of expressed proteins and their post-translational modifications. An update on proteomics-driven research for developing early biomarkers and understanding the molecular aspects of PD, along with their translational snags, challenges and future possibilities, are discussed in this review.
Srivastava
Garima
G
Indian Institute of Toxicology Research (Council of Scientific and Industrial Research), Lucknow-226 001, India.
Singh
Kavita
K
Tiwari
Manindra Nath
MN
Singh
Mahendra Pratap
MP
D000818:Animals; D015415:Biomarkers; D006801:Humans; D009419:Nerve Tissue Proteins / Q000032:analysis*; D010300:Parkinson Disease / Q000175:diagnosis*; D040901:Proteomics / Q000379:methods* / Q000639:trends
D015415:Biomarkers; D009419:Nerve Tissue Proteins