Regulatory long non-coding RNAs and neuronal disorders.
Increasing evidence suggests that GABA neuropathies play a major role in a variety of neuronal disorders. In addition, the role of non-coding RNAs in regulating a wide range of cellular processes is an intense area of investigation. This commentary discusses the intersection of these two fields, a corollary to the finding that adult hippocampal GABAergic interneuron development is controlled by an embryonic non-coding RNA during development.
Kohtz
Jhumku D
JD
Developmental Biology and Department of Pediatrics, Children's Memorial Hospital and Feinberg School of Medicine, Northwestern University, Box 204, 2430 N. Halsted, Chicago, IL 60614, United States. j-kohtz@northwestern.edu
Berghoff
Emily G
EG
D000818:Animals; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D006624:Hippocampus / Q000254:growth & development / Q000378:metabolism; D006801:Humans; D007395:Interneurons / Q000378:metabolism; D009422:Nervous System Diseases / Q000235:genetics* / Q000378:metabolism*; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism*; D038621:Regulatory Sequences, Ribonucleic Acid / Q000235:genetics; D015533:Transcriptional Activation / Q000235:genetics*; D005680:gamma-Aminobutyric Acid / Q000235:genetics / Q000378:metabolism*
D022661:RNA, Untranslated; D038621:Regulatory Sequences, Ribonucleic Acid; D005680:gamma-Aminobutyric Acid