title: [Impact of preemptive analgesia on postoperative pain syndrome in laparoscopic surgery].
abstract: The study included 90 patients who had undergone laparoscopic cholecystectomy. The patients were divided into 3 groups: 1) paracetamol was given for preemptive and postoperative analgesia; 2) ketorolac tromethamine; and 3) promedol (a control group). The visual analogue scale (VAS) and the determination of the time course of changes in the blood levels of tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and glucose were used to evaluate the degree of pain syndrome. Preemptive analgesia in laparoscopic surgery using ketorolac and paracetamol could reduce the degree of postoperative pain syndrome by 40.1%, as shown by the VAS. Comparative analysis of the characteristics of the agents showed that paracetamol produced a more powerful antistress defense, as confirmed by the time course of changes in the levels of TNF-alpha and CRP.
authors.forename: V N
authors.initials: VN
authors.lastname: Kokhno
authors.forename: P S
authors.initials: PS
authors.lastname: Shmerko
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Shakhtarin
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage*; D000328:Adult; D000698:Analgesia / Q000379:methods*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects*; D005260:Female; D005705:Gallbladder Diseases / Q000601:surgery; D006801:Humans; D020911:Ketorolac Tromethamine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control*; D011300:Preoperative Care; D011396:Promedol / Q000008:administration & dosage; D013577:Syndrome
chemical_list: D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; D020911:Ketorolac Tromethamine; D011396:Promedol