title: [Lentinan induces the expression of human-beta-defensin-2 in pulmonary epithelial cells].
abstract: To determine whether lentinan could upregulate the expression of human-beta-defensin-2(HBD-2) in pulmonary epithelial cells (SPC-A-1), we stimulated pulmonary epithelial cells with lentinan and detected the expression of HBD-2mRNA by RT-PCR test. The results demonstrated that the expression of HBD-2mRNA in SPC-A-1 could be induced by lentinan in a concentration and time-dependent manner.
authors.affiliation: Department of Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Birong
authors.initials: B
authors.lastname: Dong
authors.forename: Lihua
authors.initials: L
authors.lastname: Teng
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D007912:Lentinan / Q000494:pharmacology*; D008168:Lung / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D023083:beta-Defensins / Q000235:genetics / Q000378:metabolism*
chemical_list: D000276:Adjuvants, Immunologic; C106641:DEFB4A protein, human; D012333:RNA, Messenger; D023083:beta-Defensins; D007912:Lentinan