Latest advancements on serotonin and dopamine transporters in lymphocytes.
Different data show that circulating lymphocytes possess functional serotonin and dopamine transporters (SERT and DAT, respectively). This papers aims to review most of the available literature on this topic, while highlighting the possible role of SERT and DAT, as well as that of their substrates including antidepressants on the immune system.
Marazziti
Donatella
D
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma 67, Pisa, Italy. dmarazzi@psico.med.unipi.it
Consoli
Giorgio
G
Masala
Irene
I
Catena Dell'Osso
Mario
M
Baroni
Stefano
S
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology; D050483:Dopamine Plasma Membrane Transport Proteins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D056747:Immunomodulation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000502:physiology*; D012701:Serotonin / Q000502:physiology; D050486:Serotonin Plasma Membrane Transport Proteins / Q000737:chemistry / Q000502:physiology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000494:pharmacology
D000929:Antidepressive Agents, Tricyclic; D004298:Dopamine; D050483:Dopamine Plasma Membrane Transport Proteins; D012701:Serotonin; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors