title: Protein glycation, insulin sensitivity and pancreatic beta cell function in high-risk, non-diabetic, first degree relatives of patients with type 2 diabetes.
abstract: Insulin resistance and impaired beta cell function are widely recognized as features of type 2 diabetes. But it is still debated whether insulin resistance or beta cell dysfunction constitutes the primary abnormality. This study was done to evaluate the impact of family history of type 2 diabetes on insulin resistance, beta cell function and glycation of proteins. A total of 30 healthy subjects with a positive family history of type 2 diabetes and thirty two healthy age-matched subjects without any family history of type 2 diabetes were enrolled in this study. Fasting glucose, post prandial glucose, fasting plasma insulin, fructosamine and glycated hemoglobin were evaluated in both the study groups. The mean fasting glucose, fasting Insulin and HOMA-IR were significantly higher among the first-degree relatives of type 2 diabetics, but there was no alteration in HOMA-B. The levels of both glycated hemoglobin and fructosamine were significantly increased in the test group when compared with controls. In conclusion the results from the present study suggest that Indian subjects with family history of type 2 diabetes are associated with insulin resistance and enhanced glycation of proteins, but with no evidence of beta cell defect.
authors.affiliation: Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry - 605 006.
authors.forename: V
authors.initials: V
authors.lastname: Sathiyapriya
authors.forename: Zachariah
authors.initials: Z
authors.lastname: Bobby
authors.forename: Aparna
authors.initials: A
authors.lastname: Agrawal
authors.forename: N
authors.initials: N
authors.lastname: Selvaraj
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D019270:Fructosamine / Q000097:blood; D020022:Genetic Predisposition to Disease; D006442:Glycated Hemoglobin / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007194:India / Q000453:epidemiology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000208:ethnology / Q000235:genetics*; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D008875:Middle Aged; D010375:Pedigree; D018570:Risk Assessment; D012307:Risk Factors; D015854:Up-Regulation
chemical_list: D001786:Blood Glucose; D019270:Fructosamine; D006442:Glycated Hemoglobin; D007328:Insulin; C517652:hemoglobin A1c protein, human