Isolation, synthesis and structures of ginsenoside derivatives and their anti-tumor bioactivity.
Protopanaxatriol saponins obtained with AB-8 macroporous resin mainly consisted of ginsenosides Rg(1) and Re. A novel mono-ester of ginsenoside-Rh(1) (ginsenoside-ORh(1)) was synthesized through further enzymatic hydrolysis and octanoyl chloride modifications. A 53% yield was obtained by a facile synthetic method. The structures were identified on the basis of 1D-NMR and 2D-NMR, as well as ESI-TOF-MS mass spectroscopic analyses. The isolated and synthetic compounds were applied in an anti-tumor bioassay, in which ginsenoside ORh(1) showed moderate effects on Murine H22 Hepatoma Cells.
Han
Mei
M
College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Hou
Jin-Gang
JG
Dong
Cheng-Ming
CM
Li
Wei
W
Yu
Hao-Lun
HL
Zheng
Yi-Nan
YN
Chen
Li
L
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D036145:Ginsenosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D012502:Sapogenins / Q000737:chemistry
D000970:Antineoplastic Agents; D036145:Ginsenosides; D012502:Sapogenins; C081552:protopanaxatriol