title: Scalable synthesis of cryptophane-1.1.1 and its functionalization.
abstract: Cryptophanes, cage molecules for which xenon exhibits a high affinity, are good candidates for xenon biosensing. Cryptophane-1.1.1 (1) exhibits the highest binding constant for xenon encapsulation in organic solution determined to date. This property suggests that the cryptophane-1.1.1 core (1) is optimal for sensing applications. A high-yielding scalable synthesis of compound 1 is reported as well as an easy way to functionalize it.
authors.affiliation: CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, Gif sur Yvette, F-91191, France.
authors.forename: Ténin
authors.initials: T
authors.lastname: Traoré
authors.forename: Léa
authors.initials: L
authors.lastname: Delacour
authors.forename: Sébastien
authors.initials: S
authors.lastname: Garcia-Argote
authors.forename: Patrick
authors.initials: P
authors.lastname: Berthault
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Cintrat
authors.forename: Bernard
authors.initials: B
authors.lastname: Rousseau
mesh_terms: D019281:Dimerization; D019800:Phenol / Q000737:chemistry; D011083:Polycyclic Compounds; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D014978:Xenon / Q000032:analysis* / Q000737:chemistry*
chemical_list: D011083:Polycyclic Compounds; D014230:Triazoles; C523242:cryptophane; D019800:Phenol; D014978:Xenon