title: Effects of a short-acting [beta]1 receptor antagonist landiolol on hemodynamics and tissue injury markers in patients with subarachnoid hemorrhage undergoing intracranial aneurysm surgery.
abstract: Sympathetic activation after subarachnoid hemorrhage (SAH) can induce tachycardia as well as cardiac and brain injury. We examined the effects of beta1 receptor antagonist landiolol on hemodynamics and the levels of tissue injury markers in patients with SAH. Fifty-six SAH patients undergoing intracranial aneurysm surgery with tachycardia (>or=90 beats per minute) randomly allocated to landiolol (L) or control (C) group were examined. In L group, landiolol was continuously administered during anesthesia. In C group, landiolol was not administered except bolus dose used in cases that exhibited uncontrolled tachycardia. Hemodynamics, the incidence of electrocardiographic abnormality, and levels of B-type natriuretic peptide, troponin T, S-100beta, 8-Hydroxy-2'-deoxyguanosine, interleukin-6 (IL-6), and IL-1 receptor antagonist were compared. Heart rate values from time of intubation to the end of anesthesia were significantly lower in L group than in C group, whereas blood pressure was similar between the groups. Although the incidence of bradycardia (<60 beats per minute) was significantly higher in L group than in C group (57% vs. 18%, respectively), bradycardia could be recovered without any adverse effects. The serum S-100beta levels 24 hours after operation were significantly lower in L group than in C group, whereas there were no significant differences in the incidence of electrocardiographic abnormality and levels of B-type natriuretic peptide, troponin T, 8-Hydroxy-2'-deoxyguanosine, IL-6, and IL-1 receptor antagonist between groups. We conclude that landiolol can be effectively used in the treatment of tachycardia in SAH patients and significantly reduced the serum S-100beta levels 24 hours after the operation.
authors.affiliation: Department of Anesthesiology, Nara Medical University, Kashihara, Nara, Japan. drjkawa@naramed-u.ac.jp
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: Kouji
authors.initials: K
authors.lastname: Utada
authors.forename: Kenji
authors.initials: K
authors.lastname: Yoshitani
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Uchino
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Takeda
authors.forename: Kenichi
authors.initials: K
authors.lastname: Masui
authors.forename: Takefumi
authors.initials: T
authors.lastname: Sakabe
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000473:pathology; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006331:Heart Diseases / Q000473:pathology; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000494:pharmacology*; D009414:Nerve Growth Factors / Q000378:metabolism; D019635:Neurosurgical Procedures; D018342:Receptors, Adrenergic, beta-1 / Q000187:drug effects*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000378:metabolism; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology* / Q000601:surgery*; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000319:Adrenergic beta-Antagonists; D015415:Biomarkers; D009025:Morpholines; D009414:Nerve Growth Factors; D018342:Receptors, Adrenergic, beta-1; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C077049:landiolol; D014508:Urea