Interfacing live cells with nanocarbon substrates.
Nanocarbon materials, including single-walled carbon nanotubes (SWCNTs) and graphene, promise various novel biomedical applications (e.g., nanoelectronic biosensing). In this Letter, we study the ability of SWCNT networks and reduced graphene oxide (rGO) films in interfacing several types of cells, such as neuroendocrine PC12 cells, oligodendroglia cells, and osteoblasts. It was found that rGO is biocompatible with all these cell types, whereas the SWCNT network is inhibitory to the proliferation, viability, and neuritegenesis of PC12 cells, and the proliferation of osteoblasts. These observations could be attributed to the distinct nanotopographic features of these two kinds of nanocarbon substrates.
Agarwal
Shuchi
S
School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457.
Zhou
Xiaozhu
X
Ye
Feng
F
He
Qiyuan
Q
Chen
George C K
GC
Soo
Jianchow
J
Boey
Freddy
F
Zhang
Hua
H
Chen
Peng
P
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D006108:Graphite / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D037742:Nanotubes, Carbon / Q000737:chemistry*; D016501:Neurites / Q000187:drug effects; D009836:Oligodendroglia / Q000166:cytology*; D010006:Osteoblasts / Q000166:cytology*; D016716:PC12 Cells; D010316:Particle Size; D051381:Rats; D013499:Surface Properties
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D037742:Nanotubes, Carbon; D006108:Graphite