Selective activation of mGluR8 receptors modulates retinal ganglion cell light responses.
Extracellular and whole-cell light-evoked responses of mouse retinal ganglion cells were recorded in the presence of the mGluR8 selective agonist, (S)-3,4-dicarboxy-phenylglycine (DCPG). Off-light responses were reversibly reduced in the presence of DCPG in wild-type but not in mGluR8-deficient retinas. On-responses were only marginally modulated by DCPG. During Off-responses, DCPG suppressed both excitatory and inhibitory synaptic conductances suggesting that mGluR8 receptor activity reduces glutamate release from bipolar cell terminals and possibly also the release of an inhibitory neurotransmitter from amacrine cell processes.
Quraishi
S
S
Neurological Sciences Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
Reed
B T
BT
Duvoisin
R M
RM
Taylor
W R
WR
D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D005071:Evoked Potentials; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008027:Light; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018408:Patch-Clamp Techniques; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists* / Q000235:genetics / Q000502:physiology; D012165:Retinal Ganglion Cells / Q000502:physiology / Q000528:radiation effects*; D055366:Synaptic Potentials
C110733:3,4-dicarboxyphenylglycine; D001565:Benzoates; D018094:Receptors, Metabotropic Glutamate; C111435:metabotropic glutamate receptor 8; D005998:Glycine