title: Beneficial electrophysiological effects of trimetazidine in patients with postischemic chronic heart failure.
abstract: The aim of the study was to assess whether trimetazidine (TMZ) could affect dispersion of atrial depolarization and ventricular repolarization. Corrected QT interval (QTc), QTc dispersion (QTc-d), Tpeak-Tend, and Tpeak-Tend dispersion (Tpeak-Tend-d) were measured in 30 patients with chronic heart failure (CHF) before and 6 months after randomization to conventional therapy plus TMZ (17 patients) or conventional therapy alone (13 patients). After 6 months, QTc was significantly reduced in both groups, whereas QT-peak was increased only in control group. Tpeak-Tend-d decreased (from 63.53 +/- 24.73 to 42.35 +/- 21.07 milliseconds, P = .006) only in TMZ group. When subgrouped according to CHF etiology, only ischemic patients on TMZ showed Tpeak-Tend-d reduction (65.00 +/- 27.14 vs 36.67 +/- 11.55 milliseconds, P = .001 in ischemic patients; 60.00 +/- 20.00 vs 56.00 +/- 33.86 milliseconds, P = NS, in nonischemic). These electrophysiological properties indicate an undiscovered mechanism of action of TMZ, which could be useful in conditions at risk of major arrhythmias.
authors.affiliation: Clinical Cardiology-Heart Failure Unit, San Raffaele Scientific Institute, Milan, Italy. michelacera@gmail.com
authors.forename: Michela
authors.initials: M
authors.lastname: Cera
authors.forename: Anna
authors.initials: A
authors.lastname: Salerno
authors.forename: Gabriele
authors.initials: G
authors.lastname: Fragasso
authors.forename: Claudia
authors.initials: C
authors.lastname: Montanaro
authors.forename: Chiara
authors.initials: C
authors.lastname: Gardini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Marinosci
authors.forename: Francesco
authors.initials: F
authors.lastname: Arioli
authors.forename: Roberto
authors.initials: R
authors.lastname: Spoladore
authors.forename: Alberto
authors.initials: A
authors.lastname: Facchini
authors.forename: Cosmo
authors.initials: C
authors.lastname: Godino
authors.forename: Alberto
authors.initials: A
authors.lastname: Margonato
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000987:Antisocial Personality Disorder / Q000453:epidemiology / Q000523:psychology; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000188:drug therapy*; D002908:Chronic Disease; D004562:Electrocardiography / Q000187:drug effects; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications; D012307:Risk Factors; D014292:Trimetazidine / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D014292:Trimetazidine