title: Influence of Geant4 parameters on dose distribution and computation time for carbon ion therapy simulation.
abstract: The aim of this work was to study the influence of Geant4 parameters on dose distribution and computational time for simulations of carbon ion therapy. The study was done using Geant4 version 9.0. The dose distribution in water for incident monoenergetic carbon ion beams of 300 MeV/u were compared for different values of secondary particle production threshold and different step limits. Variations of depth dose of about 2 mm were observed in some cases, which induced a 30% variation of dose deposit in the Bragg peak region. Other tests were done using Geant4 version 9.2 to verify the results from this study. The two versions provided converging results and led to the same conclusions.
authors.affiliation: Université de Lyon, 69622 Lyon, France. zahra@lyon.fnclcc.fr
authors.forename: Nabil
authors.initials: N
authors.lastname: Zahra
authors.forename: Thibault
authors.initials: T
authors.lastname: Frisson
authors.forename: Loic
authors.initials: L
authors.lastname: Grevillot
authors.forename: Philippe
authors.initials: P
authors.lastname: Lautesse
authors.forename: David
authors.initials: D
authors.lastname: Sarrut
mesh_terms: D002244:Carbon / Q000627:therapeutic use*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy; D011829:Radiation Dosage; D011879:Radiotherapy Dosage; D012984:Software; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D035501:Uncertainty
chemical_list: D002244:Carbon