Umbilical cord transplantation: epilogue.
The field of cord blood transplantation has come a long way since the first transplant more than 20 years ago. Advancements in the field will require continuing efforts to better understand hematopoietic stem and progenitor cell function and engraftment. Cautious optimism is inherent in the potential relevance and applicability of nonhematopoietic stem and progenitor cell types found in cord blood, and induced pluripotent stem cells generated from cord blood cells. Rigorous investigations and close interactions between scientific and clinical investigators are required to translate human in vitro and animal in vivo findings into clinical utility.
Broxmeyer
Hal E
HE
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202-5181, USA. hbroxmey@iupui.edu
D000818:Animals; D036101:Cord Blood Stem Cell Transplantation / Q000266:history / Q000639:trends; D018380:Hematopoietic Stem Cell Transplantation / Q000266:history / Q000639:trends; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D057170:Translational Research, Biomedical / Q000266:history / Q000639:trends; D016896:Treatment Outcome