Magnetic resonance spectroscopy on hepatocellular carcinoma after transcatheter arterial chemoembolization.
OBJECTIVE
Proton magnetic resonance spectroscopy (MRS) of the liver in vivo is in experimental phase. MRS observation on liver cancer after transcatheter arterial chemoembolization (TACE) has seldom been reported. This study was to investigate the value of MRS in assessing the metabolic changes of hepatocellular carcinoma (HCC) after TACE.


METHODS
Twenty-five consecutive patients with pathologically-confirmed HCC received 1H MRS of all hepatic lesions using 1.5T whole body MR scanner before TACE and at 3-10 days after TACE. Choline-to-lipid (Cho/Lip), glucogen/glucose-to-lipid (Glu/Lip), and glytamine/glutamate-to-lipid (Glx/Lip) ratios were measured and analyzed statistically.


RESULTS
The Cho/Lip, Glu/Lip, and Glx/Lip ratios were 0.21 +/- 0.08, 0.11 +/- 0.05, 0.28 +/- 0.10 before TACE, respectively, and were 0.10 +/- 0.08, 0.07 +/- 0.07, 0.18 +/- 0.12 after TACE, respectively, with significant differences (P < 0.05).


CONCLUSIONS
Using MRS can evaluate the early metabolic responses of HCC to TACE.
Bian
Du-Jun
DJ
Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, PR China. cjr.xiaoenhua@vip.163.com
Xiao
En-Hua
EH
Hu
Dong-Xu
DX
Chen
Xiang-Yu
XY
Situ
Wei-Jun
WJ
Yuan
Shu-Wen
SW
Sun
Jian-Ling
JL
Yang
Li-Ping
LP
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D002794:Choline / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000032:analysis; D008113:Liver Neoplasms / Q000378:metabolism / Q000628:therapy*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged
D008055:Lipids; D005973:Glutamine; D018698:Glutamic Acid; D006003:Glycogen; D005947:Glucose; D002794:Choline