title: Effect of 35 years beta-adrenergic blockade therapy on autonomic cardiovascular modulation. A case study.
abstract: The influence of long duration beta-blockade on autonomic and cardiovascular function remains not completely understood. The aim of this study was to evaluate the effect of long duration beta-adrenergic blockade treatment for hypertension control, on autonomic cardiovascular control in a 78-year-old male patient in relation to population findings. Heart rate variability was determined in the frequency domain (Total power, low frequency power and high frequency power), during baseline (supine and standing) and during 24 hour Holter recording. Results were compared with heart rate and heart rate variability data obtained from a normal healthy male population as a function of age. Circadian rhythm remained present. Heart rate during daytime was lower compared to the population group. None of the heart rate variability parameters were different from the normal population age group. Our results show that after 35 years of beta-blockade treatment, autonomic modulation of cardiac function remains within normal limits for that age group. Blood pressure remained at the higher limits (120-150/60-80 mmHg), but under control.
authors.affiliation: Laboratory of Experimental Cardiology, University Hospital Gasthuisberg, KULeuven, Leuven, Belgium. Andre.aubert@med.kuleuven.be
authors.forename: A E
authors.initials: AE
authors.lastname: Aubert
authors.forename: B
authors.initials: B
authors.lastname: Verheyden
authors.forename: F
authors.initials: F
authors.lastname: Beckers
authors.forename: H
authors.initials: H
authors.lastname: Kesteloot
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000368:Aged; D001341:Autonomic Nervous System / Q000187:drug effects*; D002940:Circadian Rhythm; D015716:Electrocardiography, Ambulatory; D006329:Heart Conduction System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D012044:Regression Analysis
chemical_list: D000319:Adrenergic beta-Antagonists