An anticancer drug delivery system based on surfactant-templated mesoporous silica nanoparticles.
Three types of surfactant-templated mesoporous silica nanoparticles (Surf@MSNs) of 150-660 nm in diameter were developed as anticancer drug delivery systems. The Surf@MSNs exhibit the high drug (surfactant) loading capacities, the sustained drug (surfactant) release profiles and the high and long-term anticancer efficacy. The effects of the Surf@MSNs concentration, the type of the contained surfactants and the incubation time on the cytotoxicity and proliferative activity of MCF-7 cells were evaluated. A common anticancer drug CPT-11 was also loaded into surfactant-free MSNs (CPT@MSNs) and used as a reference for estimating the anticancer efficacies of Surf@MSNs. Surfactant-extracted MSNs exhibited neglectable cytotoxicity to MCF-7 cell, and free surfactants exhibited higher cytotoxicity than free CPT-11 at the same concentration. The endocytosis enhanced the drug uptake by MCF-7 cells and the anticancer efficacies of Surf@MSNs and CPT@MSNs, and more surfactants would be released in a longer term, which led to the more significant enhancement of the cytotoxicity, than CPT-11 with the process of incubation. Among the investigated Surf@MSNs, CTAB-contained MSNs (CTAB@MSNs) show remarkably higher long-term anticancer efficacy than CPT-11-loaded surfactant-free MSNs (CPT@MSNs), even at very low concentrations of 2-15 microg mL(-1).
He
Qianjun
Q
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China.
Shi
Jianlin
J
Chen
Feng
F
Zhu
Min
M
Zhang
Lingxia
L
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D016503:Drug Delivery Systems; D004705:Endocytosis; D005456:Fluorescent Dyes; D006801:Humans; D000077146:Irinotecan; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D012822:Silicon Dioxide / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry* / Q000494:pharmacology; D014961:X-Ray Diffraction
D000972:Antineoplastic Agents, Phytogenic; D005456:Fluorescent Dyes; D013501:Surface-Active Agents; D012822:Silicon Dioxide; D000077146:Irinotecan; D002166:Camptothecin