Plasma concentration of angiopoietin-1, angiopoietin-2 and Tie-2 in cervical cancer.
OBJECTIVE
Angiogenesis is important in the promotion and progression of malignancy. The formation of new blood vessels is coordinated by many factors, angiopoietins among others. Overexpression of angiopoietins has been observed in various tumors. The aim of the study was to evaluate plasma concentration of Ang-1, Ang-2 and Tie-2 in cervical cancer.


METHODS
The study group consisted of 34 patients with cervical cancer and the control group of 20 healthy volunteers. Plasma concentrations of Ang-1, Ang-2 and Tie-2 were evaluated by ELISA.


RESULTS
Plasma concentrations of Ang-1, Ang-2, Tie-2 and Ang-1/Ang-2 ratios were significantly higher in cervical cancer patients than in controls. Although there was no correlation between concentration of Ang-1, Ang-2, Tie-2 and clinical stage (FIGO), the Ang-1/Ang-2 ratio was higher in Stage I than in II-III. Ang-1 correlated positively with Ang-2 and Tie-2 in a subgroup with Stage II-III and Ang-2 with Tie-2 in a subgroup with Stage I.


CONCLUSIONS
Plasma concentrations of Ang- 1, Ang-2 and Tie-2 may be useful additional tumor markers in cervical cancer.
Kopczyńska
E
E
Department of Pathobiochemistry and Clinical Chemistry, Collegim Medicum, Nicolaus Copernicus University, Torum, Poland. kopczynska@cm.umk.pl
Makarewicz
R
R
Biedka
M
M
Kaczmarczyk
A
A
Kardymowicz
H
H
Tyrakowski
T
T
D042683:Angiopoietin-1 / Q000097:blood*; D042702:Angiopoietin-2 / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D042787:Receptor, TIE-2 / Q000097:blood*; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000175:diagnosis
D042683:Angiopoietin-1; D042702:Angiopoietin-2; D042787:Receptor, TIE-2