Recent synthetic approaches towards the antiproliferative natural products avrainvillamide and stephacidin B.
Due to their strong antiproliferative activity and their unprecedented structural complexity within the class of indole alkaloids, avrainvillamide and stephacidin B have recently attracted considerable interest from the synthetic community. To date, three distinct approaches towards these molecules have been disclosed and the present tutorial review aims at comparing all three syntheses with a focus on the various strategies and methods employed. Besides, recent progress towards the synthesis of structural analogs and the identification of the biological target of avrainvillamide will be presented.
Nising
Carl F
CF
Bayer Cropscience AG, Alfred-Nobel-Strasse 50, D-40789 Monheim am Rhein, Germany. carlfriedrich.nising@bayercropscience.com
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000970:Antineoplastic Agents; D026121:Indole Alkaloids; D007211:Indoles; C480558:avrainvillamide; C470894:stephacidin B