Tetranectin is a potential biomarker in cerebrospinal fluid and serum of patients with epilepsy.
BACKGROUND
Tetranectin (TN) is a plasminogen kringle 4 binding protein and regulates fibrinolysis and proteolytic processes via binding to plasminogen. A previous proteomics study identified TN in the cerebrospinal fluid (CSF) of epileptic patients but not in healthy controls. We determined the concentrations of TN in CSF and serum of epileptic patients to evaluate the changes in TN levels after epileptic attack.


METHODS
We detected TN in the CSF and serum of 64 epileptic patients and 26 healthy subjects using sandwich enzyme-linked immunosorbent assays.


RESULTS
Compared with the control group, CSF-TN levels increased in epileptic patients while serum-TN levels decreased. These differences were statistically significant. The decrease of serum-TN in patients with drug-refractory epilepsy was the most striking.


CONCLUSIONS
CSF-TN and serum-TN are potential biomarkers in epilepsy and drug-refractory epilepsy and would be useful for diagnosis.
Wang
Liang
L
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, China.
Pan
Yumin
Y
Chen
Dan
D
Xiao
Zheng
Z
Xi
Zhiqin
Z
Xiao
Fei
F
Wang
Xuefeng
X
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D002555:Cerebrospinal Fluid / Q000737:chemistry / Q000378:metabolism*; D002648:Child; D004827:Epilepsy / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D005260:Female; D006801:Humans; D037181:Lectins, C-Type / Q000097:blood*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D015415:Biomarkers; D037181:Lectins, C-Type; C048648:tetranectin