title: Mechanistic considerations for the advanced oxidation treatment of fluoroquinolone pharmaceutical compounds using TiO(2) heterogeneous catalysis.
abstract: Pharmaceutical compounds and metabolites are being found in surface and ground waters which is indicative of inefficient removal by conventional wastewater treatment technologies. Advanced oxidation processes (AOPs), which utilize free-radical reactions to degrade chemical contaminates, are an alternative to traditional water treatment. Three fluoroquinolone pharmaceutical compounds were studied and the absolute rate constants for hydroxyl radical (*OH) and hydrated electron (e(-)(aq)) are reported. For norfloxacin, levofloxacin, and lomefloxacin, the bimolecular reaction rate constants with *OH were determined as (6.18 +/- 0.18) x 10(9), (7.59 +/- 0.16) x 10(9) and (8.04 +/- 0.62) x 10(9) M(-1) s(-1), and with e(-)(aq) were (1.18 +/- 0.10) x 10(10), (2.46 +/- 0.05) x 10(10) and (2.79 +/- 0.05) x 10(10) M(-1) s(-1), respectively. To provide insights into the chemistry of destruction of these three target pharmaceuticals, transient spectra were obtained for the reaction of hydroxyl radicals with the three compounds. Photocatalysis was chosen as a representative advanced oxidation technology to degrade these three fluoroquinolones and their degradation pathways were proposed. Elimination of piperazynilic ring in fluoroquinolone molecules, addition of hydroxyl radical to quinolone ring, and ipso attack at the F atoms on the aromatic ring by hydroxyl radicals occurred. These results indicate that AOPs involving production of *OH radicals are efficiently alternative treatment technologies for degradation of fluoroquinolones in aqueous solution.
authors.affiliation: State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Resources Utilization and Protection, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China. antc99@gig.ac.cn
authors.forename: Taicheng
authors.initials: T
authors.lastname: An
authors.forename: Hai
authors.initials: H
authors.lastname: Yang
authors.forename: Weihua
authors.initials: W
authors.lastname: Song
authors.forename: Guiying
authors.initials: G
authors.lastname: Li
authors.forename: Haiying
authors.initials: H
authors.lastname: Luo
authors.forename: William J
authors.initials: WJ
authors.lastname: Cooper
mesh_terms: D002384:Catalysis; D024841:Fluoroquinolones / Q000737:chemistry*; D017665:Hydroxyl Radical / Q000138:chemical synthesis / Q000737:chemistry; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: D024841:Fluoroquinolones; D004364:Pharmaceutical Preparations; C009495:titanium dioxide; D017665:Hydroxyl Radical; D014025:Titanium