title: A case of chikungunya fever imported from India to Japan, follow-up of specific IgM and IgG antibodies over a 6-month period.
abstract: Chikungunya fever is an arboviral disease caused by chikungunya virus. A 37-year-old Japanese male visited India and developed fever, myalgia, rash, and persisting systemic arthralgia, the latter of which persisted for more than 2 months. The patient was diagnosed with chikungunya fever by virological and serological examinations. In the present study, we followed specific antibody responses over a 6-month period after the onset of the disease. IgM antibody was detected on days 58 and 108, but not on day 137, by enzyme-linked immunosorbent assay. Specific IgG and neutralizing antibodies were detected as late as day 192. The results indicate that specific IgM lasts for 3 to 4 months from the onset of the disease, and that IgG lasts more than 6 months.
authors.affiliation: Department of Infectious Disease, Osaka Prefectural Institute of Public Health, Osaka City, Osaka, Japan. aoyama@iph.pref.osaka.jp
authors.forename: Ikuko
authors.initials: I
authors.lastname: Aoyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Uno
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yumisashi
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Takasaki
authors.forename: Chang-Kweng
authors.initials: CK
authors.lastname: Lim
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kurane
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kase
authors.forename: Kazuo
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D018354:Alphavirus Infections / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D000914:Antibodies, Viral / Q000097:blood; D002646:Chikungunya virus / Q000302:isolation & purification*; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007194:India; D007564:Japan; D008297:Male; D014195:Travel
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M