The effect of MS14 on Th2 cytokines pattern in Balb/C mice.
The tendency of immune response toward either Th1 or Th2 cytokine pattern can cause a number of pathologic conditions. Multiple sclerosis is postulated to be a Th1-type cell-mediated autoimmune disease. MS14--an Iranian natural product--seems to possess anti-inflammatory properties. Thus, we studied the effect of orally administered MS14 on Th2 cytokines (IL-5 and IL-10) in normal Balb/C mice (100 mg/kg; 5 days). The result indicated that activated splenocytes of MS14 group produced significantly more IL-5 and IL-10 (3-4 times in comparison with control group mice). MS14 could upregulate Th2 cytokine and thereby it may possess immunoregulatory properties probably useful in treatment of some diseases.
Yaraee
Roya
R
Department of Immunology, Medical Faculty, Medical School and Medicinal Plant Research Center, Shahed University, Tehran, Iran. ryaraee@yahoo.com
Naseri
Mohsen
M
Eghtedardoost
Marzieh
M
Ahmadi
Amrollah
A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001688:Biological Products / Q000494:pharmacology*; D005260:Female; D016753:Interleukin-10 / Q000032:analysis / Q000096:biosynthesis*; D015848:Interleukin-5 / Q000032:analysis / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D018418:Th2 Cells / Q000187:drug effects* / Q000276:immunology; D014020:Tissue Extracts / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001688:Biological Products; D015848:Interleukin-5; D010936:Plant Extracts; D014020:Tissue Extracts; D016753:Interleukin-10