Simple and effective method for producing [11C]phosgene using an environmental CCl4 gas detection tube.
BACKGROUND
Carbon-11-labeled phosgene is an important labeling precursor for PET molecular probes. Despite the usefulness of [(11)C]phosgene, some difficulties, especially in the formation of [(11)C]phosgene process from [(11)C]CCl(4), hamper its use. The present article shows a simple preparation method for [(11)C]phosgene.


METHODS
[(11)C]CCl(4) was obtained using the conventional method by passing a mixture of [(11)C]CH(4) and Cl(2) through a heated quartz tube. The [(11)C]CCl(4) was transformed to [(11)C]phosgene simply by passing through a pretreatment tube of a Kitagawa gas detection system for the working-environmental CCl(4) concentration measurement at room temperature with a flow rate of 50 ml/min.


RESULTS
This tube successfully transformed [(11)C]CCl(4) to [(11)C]phosgene at room temperature. [(11)C]Phosgene was obtained at nearly 80% radiochemical yield (EOB) in a short synthesis time with high reproducibility.


CONCLUSIONS
A high yield and reliable [(11)C]phosgene production method using a gas detector tube system for working-environmental CCl(4) concentration measurement was developed.
Ogawa
Masanao
M
Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.
Takada
Yuuki
Y
Suzuki
Hisashi
H
Nemoto
Kazuyoshi
K
Fukumura
Toshimitsu
T
D002250:Carbon Radioisotopes / Q000737:chemistry; D002251:Carbon Tetrachloride / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry*; D005740:Gases / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry*; D010705:Phosgene / Q000138:chemical synthesis* / Q000737:chemistry*; D015203:Reproducibility of Results; D013696:Temperature
D002250:Carbon Radioisotopes; D005740:Gases; D010705:Phosgene; D002251:Carbon Tetrachloride