Rosai-Dorfman disease of the nasal cavities: A CO(2) laser excision.
BACKGROUND
Rosai-Dorfman disease (RDD) is a rare nonneoplastic histiocytic proliferative disorder characterized by painless massive lymphadenopathy. Extranodal manifestations frequently occur in the head and neck area.


METHODS
We report the clinical and histological features of nasal cavities and cervical lymph node RDD in a 72-year-old woman, who complained of major nasal obstruction and hyposmia.


RESULTS
Nasal endoscopy revealed polypoid masses arising from the turbinates; the septum was intact. Immunohistochemical analysis revealed staining for S-100 protein, CD68, and alpha-1 antitrypsin. The presence of the Epstein-Barr virus was revealed by serology and also by in situ hybridization. The general examination and systemic evaluation did not find other extranodal localization.


CONCLUSIONS
Because the disease is known for not responding to local or systemic steroids, CO(2) laser excision was used to clear the nasal obstruction with a satisfactory result. This is, to the best of our knowledge, the first description of the use of laser excision for nasal cavities RDD.
Belcadhi
Malek
M
Department of Ear, Nose, and Throat, Farhat Hached University Hospital, Sousse, Tunisia. belcadhi@yahoo.fr
Bellakhdhar
Mouna
M
Sriha
Badreddine
B
Bouzouita
Kamel
K
D000368:Aged; D015703:Antigens, CD / Q000276:immunology / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology / Q000378:metabolism; D004351:Drug Resistance; D005260:Female; D015618:Histiocytosis, Sinus / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D053685:Laser Therapy; D054020:Lasers, Gas / Q000706:statistics & numerical data; D009296:Nasal Cavity / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D015508:Nasal Obstruction; D009298:Nasal Polyps; D009418:S100 Proteins / Q000276:immunology / Q000378:metabolism; D013256:Steroids / Q000627:therapeutic use; D000515:alpha 1-Antitrypsin / Q000276:immunology / Q000378:metabolism; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009418:S100 Proteins; D013256:Steroids; D000515:alpha 1-Antitrypsin; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C043392:SERPINA1 protein, human