title: An assessment of the effect of statin use on the incidence of acute respiratory infections in England during winters 1998-1999 to 2005-2006.
abstract: Statins reduce cardiovascular mortality and related risks associated with pneumonia suggesting potentially beneficial use in influenza pandemics. We investigated the effect of current statin use on acute respiratory infections in primary care. Data from anonymized electronic medical records of persons aged 45 years were examined for statin use, chronic morbidity, respiratory diagnoses, vaccination procedures, and immune suppression. Logistic regression models were used to calculate odds ratios (ORs) for statin users vs. non-users in respiratory infection outcomes. A total of 329 881 person-year observations included 18% statin users and 46% influenza vaccinees. Adjusted ORs for statin users vs. non-users were: influenza-like illness, 1.05 (95% CI 0.92-1.20); acute bronchitis, 1.08 (95% CI 1.01-1.15); pneumonia, 0.91 (95% CI 0.73-1.13); all acute respiratory infections, 1.03 (95% CI 0.98-1.07); and urinary tract infections, 0.91 (95% CI 0.85-0.98). We found no benefit in respiratory infection outcomes attributable to statin use, although uniformly higher ORs in non-vaccinated statin users might suggest synergism between statins and influenza vaccination.
authors.affiliation: Royal College of General Practitioners, Research and Surveillance Centre, Birmingham, UK. dfleming@rcgpbhamresunit.nhs.uk
authors.forename: D M
authors.initials: DM
authors.lastname: Fleming
authors.forename: N Q
authors.initials: NQ
authors.lastname: Verlander
authors.forename: A J
authors.initials: AJ
authors.lastname: Elliot
authors.forename: H
authors.initials: H
authors.lastname: Zhao
authors.forename: D
authors.initials: D
authors.lastname: Gelb
authors.forename: D
authors.initials: D
authors.lastname: Jehring
authors.forename: J S
authors.initials: JS
authors.lastname: Nguyen-Van-Tam
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D057286:Electronic Health Records; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D015994:Incidence; D007252:Influenza Vaccines / Q000008:administration & dosage; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D022242:Pneumococcal Vaccines / Q000008:administration & dosage; D011320:Primary Health Care; D012141:Respiratory Tract Infections / Q000453:epidemiology*; D012189:Retrospective Studies; D012621:Seasons
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007252:Influenza Vaccines; D022242:Pneumococcal Vaccines