[Protective properties of L-carnosine studied in vitro on a hemorrhagic stroke model].
The protective properties of L-carnosine have been studied in vitro on a model of hemorrhagic stroke developed on survival olfactory cortex slices of hypertensive rats after long-term exposure to autoblood. The preliminary application of L-carnosine in a concentration of 5 mg/ml regenerates an activity of glutamatergic and GABAergic components of focal potentials inhibited by autoblood and prevents tissue swelling. L-carnosine protects the bioelectrical activity of nerve cells after their long-term exposure to autoblood and produces an antiedematic effect.
Khama-Murad
A Kh
AKh
D000818:Animals; D002336:Carnosine / Q000494:pharmacology*; D004195:Disease Models, Animal; D020300:Intracranial Hemorrhages / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D020521:Stroke / Q000378:metabolism / Q000517:prevention & control*
D002336:Carnosine