title: Immunoreactivity of oxytocin receptor and transient receptor potential vanilloid type 1 and its correlation with dysmenorrhea in adenomyosis.
abstract: OBJECTIVE
  We sought to investigate the expression and localization of oxytocin receptor (OTR) and transient receptor potential vanilloid type 1 (TRPV1) in women with and without adenomyosis.
  
  
  METHODS
  Ectopic and homologous eutopic endometrium from 50 women with adenomyosis and endometrium from 18 women without adenomyosis were used for immunohistochemical analysis of OTR and TRPV1. Microscopic evaluation assessed the presence and localization of OTR and TRPV1 throughout the menstrual cycle in both eutopic endometrial and endometriotic tissues of women with adenomyosis and compared them with normal endometrium.
  
  
  RESULTS
  Compared with normal endometrium, immunoreactivity of OTR and TRPV1 were significantly increased in ectopic endometrium. Both OTR and TRPV1 immunoreactivity were positively correlated with the severity of dysmenorrhea and found to be significant predicators for dysmenorrhea severity.
  
  
  CONCLUSIONS
  These findings suggest that OTR and TRPV1 may be involved in dysmenorrhea and its severity in adenomyosis and may be potential therapeutic targets.
authors.affiliation: Department of Gynecology, Shanghai Obstetrics/Gynecology Hospital, Shanghai, China.
authors.forename: Jichan
authors.initials: J
authors.lastname: Nie
authors.forename: Xishi
authors.initials: X
authors.lastname: Liu
authors.forename: Sun-Wei
authors.initials: SW
authors.lastname: Guo
mesh_terms: D000328:Adult; D000906:Antibodies; D003593:Cytoplasm / Q000378:metabolism / Q000473:pathology; D004412:Dysmenorrhea / Q000378:metabolism* / Q000473:pathology; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008598:Menstruation; D008875:Middle Aged; D011237:Predictive Value of Tests; D018045:Receptors, Oxytocin / Q000276:immunology / Q000378:metabolism*; D012720:Severity of Illness Index; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D050916:TRPV Cation Channels / Q000276:immunology / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism* / Q000473:pathology
chemical_list: D000906:Antibodies; D018045:Receptors, Oxytocin; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human