[Study on the association between chronic hepatitis B cirrhosis and HLA-DRB1 * 1301,1302 allele].
OBJECTIVE
To investigate the association between the chronic hepatitis B cirrhosis and HLA-DRB1 * 1301,1302 gene.


METHODS
HLA-DRB1 * 1301,1302 allele in 27 patients with chronic hepatitis B cirrhosis and 30 patients with chronic hepatitis B was analyzed by using the polymerase chain reaction/sequence specific primer (PCR-SSP) technique.


RESULTS
The frenquency of HLA-DRB1 * 1301,1302 allele in the chronic hepatitis B cirrhosis group was markly higher than that in the chronic hepatitis B group.


CONCLUSIONS
HLA-DRB1 * 1301,1302 is closely associated with the suseptibility to chronic hepatitis cirrhosis.
Liang
Hong-Xia
HX
Department of Infectious Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Yu
Zu-Jiang
ZJ
Jiang
He-Qing
HQ
D000328:Adult; D000483:Alleles; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D019694:Hepatitis B, Chronic / Q000235:genetics*; D006801:Humans; D008103:Liver Cirrhosis / Q000235:genetics*; D008297:Male
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains