title: Mega-corpus callosum, polymicrogyria, and psychomotor retardation syndrome.
abstract: We describe two children from a consanguineous family who manifested mega-corpus callosum, polymicrogyria, and psychomotor retardation. These patients also exhibited the brain anomalies of pontine hypoplasia and an abnormal cerebellar vermis. Our report confirms the genetic nature of megalencephaly-polymicrogyria-mega-corpus callosum syndrome, suggests a possible autosomal-recessive inheritance, and expands the spectrum of this rare entity.
authors.affiliation: Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.
authors.forename: Parayil S
authors.initials: PS
authors.lastname: Bindu
authors.forename: Arun B
authors.initials: AB
authors.lastname: Taly
authors.forename: Sanjib
authors.initials: S
authors.lastname: Sinha
authors.forename: Rose D
authors.initials: RD
authors.lastname: Bharath
mesh_terms: D061085:Agenesis of Corpus Callosum; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D054220:Malformations of Cortical Development / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*; D010375:Pedigree; D011596:Psychomotor Disorders / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*; D013577:Syndrome