title: Capecitabine cardiac toxicity presenting as effort angina: a case report.
abstract: We report a case of capecitabine-induced cardiotoxicity (effort angina) in a woman with metastatic breast carcinoma. Due to cancer progression, rechallenge of therapy with capecitabine was attempted, using several strategies in order to prevent cardiotoxicity. The most (even if not fully) effective strategy was reducing capecitabine dosage together with nitrates, calcium-channel blockers and trimetazidine therapy.
authors.affiliation: Cardiologia, Centro di Riferimento Oncologico, IRCCS, via F. Gallini 2, 33081 Aviano, Pordenone, Italy. clestuzzi@cro.it
authors.forename: Chiara
authors.initials: C
authors.lastname: Lestuzzi
authors.forename: Diana
authors.initials: D
authors.lastname: Crivellari
authors.forename: Fausto
authors.initials: F
authors.lastname: Rigo
authors.forename: Elda
authors.initials: E
authors.lastname: Viel
authors.forename: Nereo
authors.initials: N
authors.lastname: Meneguzzo
mesh_terms: D000787:Angina Pectoris / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D000069287:Capecitabine; D002317:Cardiovascular Agents / Q000627:therapeutic use; D003329:Coronary Vasospasm / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D018618:Echocardiography, Doppler, Color; D018619:Echocardiography, Doppler, Pulsed; D004562:Electrocardiography; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008875:Middle Aged
chemical_list: D000964:Antimetabolites, Antineoplastic; D002317:Cardiovascular Agents; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil