[Pregnant women hepatitis B markers investigation and analysis of intrauterine infection].
OBJECTIVE
To investigate the relationship between the hepatitis B virus (HBV) infection in pregnant women and intrauterine infection in local region.


METHODS
The markers of hepatitis B (HBVM) were determined by time-resolved fluoroimmunoassay and HBV-DNA were determined by FQ-PCR.


RESULTS
A total of 1262 pregnant women were examined the HBVM, 2.6%, 38.2%, 0.9%, 22.6%, 23.1% subjects were identified HBsAg, HBsAb, HBeAg, HBeAb, HBcAb positive respectively. In 33 cases of serum HBsAg-positive pregnant women, HBV-DNA were observed in most of 11 cases of pregnant women with HBeAg-positive and intrauterine infection rates were 6/11. In contrast, 22 cases of pregnant women with HBeAg negative, HBV-DNA were detected lowly-loaded and intrauterine infection rates were 2/22 (P < 0.01). Intrauterine infection rates of HBV in pregnant women with HBsAg-positive were 24.2% (8/33).


CONCLUSIONS
HBV infective rates in pregnant women in the local region were low. Pregnant women with serum HBeAg positive and HBV-DNA high-loaded were prone to intrauterine infection.
Lu
Hui-Fen
HF
Central Hospital of Huzhou, Zhejiang 313000, China. lhf12345666@126.com
Jin
Wen-Jun
WJ
Huang
Xioa-Hong
XH
Zhao
Qin-Ying
QY
Mao
Hua-Ying
HY
D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000097:blood* / Q000276:immunology / Q000821:virology; D006510:Hepatitis B Antibodies / Q000097:blood* / Q000276:immunology; D006511:Hepatitis B Antigens / Q000097:blood* / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood* / Q000276:immunology / Q000821:virology; D014591:Uterine Diseases / Q000097:blood* / Q000276:immunology / Q000821:virology; D055815:Young Adult
D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens