title: Tetranectin is a potential biomarker in cerebrospinal fluid and serum of patients with epilepsy.
abstract: BACKGROUND
  Tetranectin (TN) is a plasminogen kringle 4 binding protein and regulates fibrinolysis and proteolytic processes via binding to plasminogen. A previous proteomics study identified TN in the cerebrospinal fluid (CSF) of epileptic patients but not in healthy controls. We determined the concentrations of TN in CSF and serum of epileptic patients to evaluate the changes in TN levels after epileptic attack.
  
  
  METHODS
  We detected TN in the CSF and serum of 64 epileptic patients and 26 healthy subjects using sandwich enzyme-linked immunosorbent assays.
  
  
  RESULTS
  Compared with the control group, CSF-TN levels increased in epileptic patients while serum-TN levels decreased. These differences were statistically significant. The decrease of serum-TN in patients with drug-refractory epilepsy was the most striking.
  
  
  CONCLUSIONS
  CSF-TN and serum-TN are potential biomarkers in epilepsy and drug-refractory epilepsy and would be useful for diagnosis.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Yumin
authors.initials: Y
authors.lastname: Pan
authors.forename: Dan
authors.initials: D
authors.lastname: Chen
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xiao
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Xi
authors.forename: Fei
authors.initials: F
authors.lastname: Xiao
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D002555:Cerebrospinal Fluid / Q000737:chemistry / Q000378:metabolism*; D002648:Child; D004827:Epilepsy / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D005260:Female; D006801:Humans; D037181:Lectins, C-Type / Q000097:blood*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015415:Biomarkers; D037181:Lectins, C-Type; C048648:tetranectin