title: Pancytopenia with severe thrombocytopenia in a patient treated with twice-weekly LDL-apheresis by polyacrylate adsorption from whole blood.
abstract: Pancytopenia with severe thrombocytopenia occurred in a patient treated with low-density lipoprotein (LDL)-apheresis by polyacrylate adsorption from whole blood, after treatment frequency had been increased from once to twice a week. Cell counts recovered with discontinuation of LDL-apheresis, but thrombocytopenia recurred after resumption of twice-weekly treatments. Thrombocyte counts remained stable following the replacement of polyacrylate adsorption from whole blood by double-filtration plasmapheresis. The complications' close coincidence with twice-weekly polyacrylate adsorption from whole blood suggests a causal relationship, although by a still unknown mechanism. Monitoring of thrombocytes should be advised in patients treated with LDL-apheresis by polyacrylate adsorption from whole blood.
authors.affiliation: Nephrology/Dialysis Centre Lindau, Friedrichshafener Str. 82, Lindau D-88131, Germany. nowack@dialyse-lindau.de
authors.forename: Rainer
authors.initials: R
authors.lastname: Nowack
authors.forename: Günther
authors.initials: G
authors.lastname: Wiedemann
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000327:Adsorption; D000328:Adult; D001781:Blood Component Removal / Q000379:methods*; D008078:Cholesterol, LDL / Q000097:blood / Q000302:isolation & purification*; D005374:Filtration; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000628:therapy; D008297:Male; D010198:Pancytopenia / Q000628:therapy*; D010956:Plasmapheresis; D013921:Thrombocytopenia / Q000628:therapy*
chemical_list: D000180:Acrylic Resins; D008078:Cholesterol, LDL; C006903:carbopol 940