Live birth after ovarian tissue autograft in a patient with sickle cell disease treated by allogeneic bone marrow transplantation.
OBJECTIVE
To report the first case of restoration of ovarian activity and live birth after cryopreserved ovarian tissue autograft in a patient without cancer treated by allogeneic bone marrow transplantation.


METHODS
Case report.


METHODS
University hospital.


METHODS
One woman with homozygous sickle cell anemia.


METHODS
An orthotopic autotransplantation of ovarian cortical strips was performed after freeze-thawing.


METHODS
Cryopreservation of ovarian tissue, bone marrow transplantation, ovarian autograft, and restoration of ovarian function.


RESULTS
In autumn 2005, biopsy samples of ovarian tissue were cryopreserved before chemotherapy followed by bone marrow transplantation. In spring 2008, because the patient had been menopausal for 2.5 years as a result of the conditioning therapy, an orthotopic autotransplantation of thawed ovarian cortex was performed. The patient conceived spontaneously in a natural cycle in autumn 2008, and delivered a healthy female child in June 2009.


CONCLUSIONS
Cryopreservation of ovarian tissue with subsequent autotransplantation is an emerging procedure for preserving the fertility of young patients with a high risk of premature ovarian failure (POF) resulting from gonadotoxic treatment. This case opens up new perspectives in cases of nonmalignant diseases.
Roux
Christophe
C
Service de Génétique Histologie Biologie du Développement et de la Reproduction (CECOS Franche-Comté Bourgogne), Centre Hospitalier Universitaire, Université de Franche-Comté, Besançon, France. christophe.roux@univ-fcomte.fr
Amiot
Clotilde
C
Agnani
Germain
G
Aubard
Yves
Y
Rohrlich
Pierre-Simon
PS
Piver
Pascal
P
D000328:Adult; D000755:Anemia, Sickle Cell / Q000534:rehabilitation* / Q000628:therapy*; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000379:methods / Q000534:rehabilitation; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth; D010053:Ovary / Q000601:surgery / Q000637:transplantation*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000534:rehabilitation / Q000628:therapy; D016649:Primary Ovarian Insufficiency / Q000209:etiology / Q000534:rehabilitation / Q000628:therapy; D019172:Transplantation Conditioning / Q000009:adverse effects; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous / Q000009:adverse effects