Arginine in the salt-induced peptide formation reaction: enantioselectivity facilitated by glycine, L- and D-histidine.
The salt-induced peptide formation reaction has been proposed as a conceivable preliminary to the prebiotic evolution of peptides. In the present paper, the behaviour of arginine is reported for this reaction together with a discussion of the catalytic effects of glycine, and L- and D-histidine. Importantly, the behaviour of the two histidine enantiomers is different. Both histidine enantiomers perform better than glycine in enhancing the yields of arginine dipeptide with L-histidine being more effective than D-histidine. Yields in the presence of histidine are up to 70 times greater than for arginine solutions alone. This compares with 4.2 times higher in the presence of glycine. This difference is most pronounced in the most concentrated (containing 80 mM arginine) reaction solution where arginine has the lowest reactivity. A distinct preference for dimerisation of L-arginine also appears in the 80 mM cases for catalyses of other amino acids. This phenomenon is different from the behaviour of aliphatic amino acids, which display obvious inherent enantioselectivity for the L-stereomers in the SIPF reaction on their own rather than when catalysed by glycine or histidine.
Li
Feng
F
Faculty of Chemistry and Pharmacy, Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 52a, 6020, Innsbruck, Austria.
Fitz
Daniel
D
Fraser
Donald G
DG
Rode
Bernd M
BM
D001120:Arginine / Q000737:chemistry*; D002384:Catalysis; D019418:Evolution, Chemical; D005998:Glycine / Q000737:chemistry*; D006639:Histidine / Q000737:chemistry*; D009842:Oligopeptides / Q000138:chemical synthesis*; D012965:Sodium Chloride / Q000494:pharmacology*; D012996:Solutions; D013237:Stereoisomerism
D009842:Oligopeptides; D012996:Solutions; D012965:Sodium Chloride; D006639:Histidine; D001120:Arginine; D005998:Glycine