title: Renal cell carcinoma: complete pathological response in a patient with gastric metastasis of renal cell carcinoma.
abstract: A 75-year-old-man, with a 2-month history of abdominal pain, underwent a standard diagnostic workup that included a CT scan that showed a large right renal mass and subcentimeter nodes in the right and left lung lobes. In December 2003, the patient underwent right nephrectomy with adrenalectomy and a diagnosis of renal cell carcinoma (pT3N0M0 stage) was made. No further treatment was proposed and patient was followed up regularly. In October 2006, the annual gastrointestinal endoscopy showed asymptomatic multilobulated and polypoid masses in the gastric fundus and gastric body that corresponded to metastasis of the renal carcinoma that had been resected three years ago. Surgical treatment was refused and oral treatment with sunitinib (50 mg/day consecutively for 4 weeks followed by 2 weeks off) was initiated. Patient completed one cycle and development of acute toxicity (grade 3 asthenia, anorexia and mucositis) led to treatment interruption. After recovering from acute toxicity, the patient was proposed to reinitiate treatment with dose reduction, but he refused any medical treatment. At the follow-up visit, three months later, the gastrointestinal endoscopy showed four unspecific 2 mm nodules without malignant evidence. The whole-body CT did not reveal any other abnormality except for the known lung nodes. PET scan six months after treatment confirmed complete gastric response.
authors.affiliation: Medical Oncology Service, University Hospital Complex, A Coruña, Spain. maria.rosario.garcia.campelo@sergas.es
authors.forename: Rosario
authors.initials: R
authors.lastname: García-Campelo
authors.forename: Maria
authors.initials: M
authors.lastname: Quindós
authors.forename: Diana Dopico
authors.initials: DD
authors.lastname: Vázquez
authors.forename: Margarita Reboredo
authors.initials: MR
authors.lastname: López
authors.forename: Alberto
authors.initials: A
authors.lastname: Carral
authors.forename: Ovidio Fernández
authors.initials: OF
authors.lastname: Calvo
authors.forename: José Manuel Rois
authors.initials: JM
authors.lastname: Soto
authors.forename: Enrique
authors.initials: E
authors.lastname: Grande
authors.forename: Jesús
authors.initials: J
authors.lastname: Durana
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Antón-Aparicio
mesh_terms: D000315:Adrenalectomy; D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000556:secondary* / Q000601:surgery; D005770:Gastrointestinal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male; D009362:Neoplasm Metastasis; D009392:Nephrectomy; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011758:Pyrroles / Q000627:therapeutic use*; D011859:Radiography; D000077210:Sunitinib; D016896:Treatment Outcome
chemical_list: D020533:Angiogenesis Inhibitors; D007211:Indoles; D047428:Protein Kinase Inhibitors; D011758:Pyrroles; D000077210:Sunitinib