[Cytokines in systemic sclerosis].
The balance in the production and release of cytokines "Th1/Th2" or "Th17" or "regulatory T" is one of the key events in the pathogenesis of systemic sclerosis (SSc). Specifically, the Th2 cytokine response, characterized by the production of IL-4, IL-10 and TGF-β, leads to tissue fibrosis in patients with SSc. Many studies have shown the importance of analyzing the levels of cytokines as diagnostic or prognostic markers in the blood or in situ in patients with SSc. The restoration of the Th1/Th2/Th17/Treg balance will contribute to the effectiveness of treatment and the use of cytokine modulators may therefore be considered in developing new therapeutic approaches.
Baraut
J
J
hôpital Saint-Louis. pavillon Bazin, Paris, France.
Farge
D
D
Jean-Louis
F
F
Kesmandt
H
H
Durant
C
C
Verrecchia
F
F
Michel
L
L
D002450:Cell Communication / Q000502:physiology; D016207:Cytokines / Q000097:blood / Q000145:classification / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D012595:Scleroderma, Systemic / Q000097:blood / Q000209:etiology / Q000276:immunology / Q000378:metabolism*; D018417:Th1 Cells / Q000378:metabolism / Q000502:physiology; D058408:Th1-Th2 Balance; D018418:Th2 Cells / Q000378:metabolism / Q000502:physiology
D016207:Cytokines