title: Total synthesis of annonaceous acetogenins belonging to the non-adjacent bis-THF and non-adjacent THF-THP sub-classes.
abstract: The synthesis of the subgroups of acetogenins containing non-adjacent bis-THF and non-adjacent THF-THP core units is reviewed. Specifically, total syntheses of gigantecin, 4-deoxygigantecin, cis-sylvaticin, squamostatin-C, squamostatin-D, sylvaticin and mucocin are discussed.
authors.affiliation: The School of Chemistry, The University of Southampton, Highfield, Southampton SO171BJ, UK.
authors.forename: Ian B
authors.initials: IB
authors.lastname: Spurr
authors.forename: Richard C D
authors.initials: RC
authors.lastname: Brown
mesh_terms: D054378:Acetogenins / Q000138:chemical synthesis* / Q000737:chemistry / Q000145:classification*; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C108757:4-deoxygigantecin; D054378:Acetogenins; D005663:Furans; D007783:Lactones; D011714:Pyrans; C413144:mucocin; C063434:sylvaticin