title: Interleukin-18 promoter polymorphisms and risk of ischemic stroke.
abstract: Ischemic stroke (IS) is a major cause of morbidity and mortality around the world. Interleukin-18 (IL-18) plays an important role in the pathogenesis of IS and IL-18 promoter polymorphisms have been shown to be associated with levels of expression of IL-18. We investigated the association of two functional polymorphisms in IL-18 promoter, -607C/A (rs1946518) and -137G/C (rs187238), with the risk of ischemic stroke in a Han Chinese population of 423 patients and 384 healthy controls matched for sex and age. The results revealed that the -607C allele was associated with an increased risk of IS with an odds ratios (OR) of 1.358 (P = 0.002, power = 100%) and the presence of the -137G allele was correlated with increased the risk of IS in the subtype of patients with large artery atherosclerosis (LAA) (OR = 1.583, P = 0.02, power = 94%). Patients with the -607C/-137G haplotype also had significantly increased risk of IS compared to controls (OR = 1.341, P = 0.005, power = 100%). Our findings suggest that these functional polymorphisms in the IL-18 promoter are involved in development of IS in the Han Chinese population.
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province 266071, China.
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.forename: Jin-Tai
authors.initials: JT
authors.lastname: Yu
authors.forename: Nan-Nan
authors.initials: NN
authors.lastname: Yu
authors.forename: Rui-Chun
authors.initials: RC
authors.lastname: Lu
authors.forename: Teng
authors.initials: T
authors.lastname: Ma
authors.forename: Nai-Dong
authors.initials: ND
authors.lastname: Wang
authors.forename: Dan
authors.initials: D
authors.lastname: Miao
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Song
authors.forename: Lan
authors.initials: L
authors.lastname: Tan
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D050197:Atherosclerosis / Q000235:genetics; D002545:Brain Ischemia / Q000235:genetics*; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D008297:Male; D017354:Point Mutation; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012306:Risk; D020521:Stroke / Q000235:genetics*
chemical_list: D020382:Interleukin-18