Cardiac myxosarcoma with adrenal adenoma and pituitary hyperplasia resembling Carney complex in a dog.
A 9-year-old female Golden Retriever was presented with an acute onset of progressive respiratory distress. Echocardiography revealed a left atrial mass that limited blood flow from the pulmonary veins. The pathological evaluation revealed a left atrial ossifying myxosarcoma, bilateral adrenocortical adenomas, multifocal pituitary hyperplasia with expression of adrenocorticotrophic hormone, and multiple pituitary Rathke's cleft cysts. These pathologic findings are similar to those described in Carney complex, a familial human syndrome characterized by cardiac myxoma and extracardiac tumors associated with mutations in the protein kinase A regulator gene PRKAR1A. Mutations were not detected in PRKAR1A exons in the present case.
Adissu
H A
HA
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
Hayes
G
G
Wood
G A
GA
Caswell
J L
JL
D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D006338:Heart Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D009236:Myxosarcoma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*