title: Microcephaly with simplified gyral pattern: MRI classification.
abstract: OBJECTIVE
  To develop subjective (visual) and objective (morphometric) rating scales for the classification of MRI in infants who had microcephaly with a simplified gyral pattern (MSGP) and to validate the first by the latter.
  
  
  METHODS
  We compared the MRI of 12 patients with MSGP and of 5 term-born control infants. Visual rating and morphometric analysis was performed for gyration and associated brain abnormalities of basal ganglia, lateral ventricles, pons, cerebellum, and corpus callosum.
  
  
  RESULTS
  Gyral pattern was rated reliably as normal in the control infants, simplified in 6 patients, and severely simplified in the other 6 patients. Associated brain abnormalities were reported in 10 of 12 patients. Visual rating correlated well with the morphometric measures.
  
  
  CONCLUSIONS
  Our visual rating scale for a simplified gyral pattern proved to be sensitive and reliable. Associated brain abnormalities are frequent, which underlines the need for a consistent scoring in these patients.
authors.affiliation: Department of Child Neurology, VU University Medical Center, De Boelelaan 1117, 1081HV, Amsterdam, the Netherlands. rj.vermeulen@vumc.nl
authors.forename: R Jeroen
authors.initials: RJ
authors.lastname: Vermeulen
authors.forename: Marko
authors.initials: M
authors.lastname: Wilke
authors.forename: Veronka
authors.initials: V
authors.lastname: Horber
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Krägeloh-Mann
mesh_terms: D061085:Agenesis of Corpus Callosum; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D008831:Microcephaly / Q000145:classification* / Q000473:pathology*; D013223:Statistics as Topic