title: Maternal periodontitis and the causes of preterm birth: the case-control Epipap study.
abstract: OBJECTIVE
  To analyse the association between maternal periodontitis and preterm birth (<37 weeks' gestation) according to the causes of preterm birth.
  
  
  METHODS
  Epipap is a case-control multi-centre study of singleton livebirths. One thousand one hundred and eight women with preterm deliveries and 1094 with deliveries at term (> or =37 weeks) at six French maternity units were included. Periodontal examinations after delivery identified localized and generalized periodontitis. Cases were classified according to four causes of preterm birth. Polytomous logistic regression analysis was used to control for confounders (maternal age, parity, nationality, educational level, marital status, employment during pregnancy, body mass index before pregnancy, smoking status) and the examiner.
  
  
  RESULTS
  Localized periodontitis was identified in 129 (11.6%) cases and in 118 (10.8%) control women and generalized periodontitis in 148 (13.4%) and 118 (10.8%), respectively. A significant association was observed between generalized periodontitis and induced preterm birth for pre-eclampsia [adjusted odds ratio 2.46 [95% confidence intervals (95% CI)1.58-3.83]. Periodontitis was not associated with spontaneous preterm birth or preterm premature rupture of membranes or with the other causes.
  
  
  CONCLUSIONS
  Maternal periodontitis is associated with an increased risk of induced preterm birth due to pre-eclampsia.
authors.affiliation: INSERM UMRS 953, Research Unit on Perinatal Health and Women's and Children's Health, Villejuif Cedex, France. cathy.nabet@inserm.fr
authors.forename: Cathy
authors.initials: C
authors.lastname: Nabet
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lelong
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Colombier
authors.forename: Michel
authors.initials: M
authors.lastname: Sixou
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Musset
authors.forename: François
authors.initials: F
authors.lastname: Goffinet
authors.forename: Monique
authors.initials: M
authors.lastname: Kaminski
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D003728:Dental Calculus / Q000453:epidemiology; D004522:Educational Status; D004651:Employment / Q000706:statistics & numerical data; D005006:Ethnicity / Q000706:statistics & numerical data; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology; D005602:France / Q000453:epidemiology; D006801:Humans; D017533:Marital Status / Q000706:statistics & numerical data; D008423:Maternal Age; D010298:Parity; D017622:Periodontal Attachment Loss / Q000453:epidemiology; D010514:Periodontal Pocket / Q000453:epidemiology; D010518:Periodontitis / Q000453:epidemiology*; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D047928:Premature Birth / Q000453:epidemiology*; D011295:Prenatal Care / Q000706:statistics & numerical data; D012307:Risk Factors; D016037:Single-Blind Method; D012907:Smoking / Q000453:epidemiology; D016388:Tooth Loss / Q000453:epidemiology