title: IKK connects autophagy to major stress pathways.
abstract: Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both transcriptional and transcription-independent pathways. NFkappaB is perhaps the transcription factor most frequently activated by stress and has been ascribed with either pro- or anti-autophagic functions, depending on the cellular context. Our results demonstrate that activation of the IKK (IkappaB kinase) complex, which is critical for the stress-elicited activation of NFkappaB, is sufficient to promote autophagy independent of NFkappaB, and that IKK is required for the optimal induction of autophagy by both physiological and pharmacological autophagic triggers.
authors.affiliation: INSERM, U848, Villejuif, France.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Criollo
authors.forename: Laura
authors.initials: L
authors.lastname: Senovilla
authors.forename: Hélène
authors.initials: H
authors.lastname: Authier
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Maiuri
authors.forename: Eugenia
authors.initials: E
authors.lastname: Morselli
authors.forename: Ilio
authors.initials: I
authors.lastname: Vitale
authors.forename: Oliver
authors.initials: O
authors.lastname: Kepp
authors.forename: Ezgi
authors.initials: E
authors.lastname: Tasdemir
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Galluzzi
authors.forename: Shensi
authors.initials: S
authors.lastname: Shen
authors.forename: Maximilien
authors.initials: M
authors.lastname: Tailler
authors.forename: Nicolas
authors.initials: N
authors.lastname: Delahaye
authors.forename: Antoine
authors.initials: A
authors.lastname: Tesniere
authors.forename: Daniela
authors.initials: D
authors.lastname: De Stefano
authors.forename: Aména Ben
authors.initials: AB
authors.lastname: Younes
authors.forename: Francis
authors.initials: F
authors.lastname: Harper
authors.forename: Gérard
authors.initials: G
authors.lastname: Pierron
authors.forename: Sergio
authors.initials: S
authors.lastname: Lavandero
authors.forename: Laurence
authors.initials: L
authors.lastname: Zitvogel
authors.forename: Alain
authors.initials: A
authors.lastname: Israel
authors.forename: Véronique
authors.initials: V
authors.lastname: Baud
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051550:I-kappa B Kinase / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D013312:Stress, Physiological / Q000235:genetics / Q000502:physiology*
chemical_list: D051550:I-kappa B Kinase