Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: example: methyleugenol, CASRN: 93-15-2.
The weight of evidence points to weak genotoxic activity of methyleugenol, the putative genotoxic carcinogen being 1'-sulphate ester metabolite. Dose response modelling of the data for methyleugenol gave a BMDL10 for male rat liver adenoma or carcinoma (combined) of 7.9 mg/kg-bw/d following adjustment to daily average doses. The MoEs ranged from 100 to 800 depending on the assumptions used in the exposure estimation.
Smith
Benjamin
B
Firmenich S.A., Switzerland. publications@ilsieurope.be
Cadby
Peter
P
Leblanc
Jean-Charles
JC
Setzer
R Woodrow
RW
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D003627:Data Interpretation, Statistical; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005054:Eugenol / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D008297:Male; D051379:Mice; D015233:Models, Statistical; D009153:Mutagens / Q000633:toxicity*; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology; D051381:Rats
D002273:Carcinogens; D009153:Mutagens; C005223:methyleugenol; D005054:Eugenol