Polymorphisms in MMP-2 and MMP-9 promoter regions are associated with endometriosis.
In this case-control study, we investigated the potential associations of MMP-2 and MMP-9 gene promoter region polymorphisms as well as MMP-2 promoter haplotypes with susceptibility to endometriosis in women of caucasian origin. The results demonstrated that polymorphisms in MMP-2 (-735 C/T) and MMP-9 (-1562 C/T) were associated with elevated risk of endometriosis and that certain MMP-2 promoter haplotypes were more common in control group.
Saare
Merli
M
Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia. Electronic address: merli.saare@ut.ee.
Lamp
Merit
M
Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia.
Kaart
Tanel
T
Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Tartu, Estonia.
Karro
Helle
H
Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia; Tartu University Hospital's Women's Clinic, Tartu, Estonia.
Kadastik
Ülle
Ü
Tartu University Hospital's Women's Clinic, Tartu, Estonia.
Metspalu
Andres
A
Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia; Estonian Biocenter, Tartu, Estonia; Estonian Genome Project, University of Tartu, Tartu, Estonia.
Peters
Maire
M
Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia; Estonian Biocenter, Tartu, Estonia.
Salumets
Andres
A
Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia; Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia; Nova Vita Clinic, Center for Infertility Treatment and Medical Genetics, Viimsi, Estonia.
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D014591:Uterine Diseases / Q000235:genetics*; D055815:Young Adult
D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9