Increased levels of oxidants and reduced antioxidants in semen of infertile men with varicocele.
Significantly higher levels of oxidants (malonaldehyde and nitric oxide) and reduced levels of antioxidants (superoxide dismutase, glutathione peroxidase, catalase, and ascorbic acid) are seen in semen of infertile men with varicocele. Seminal oxidative stress (OS) seen in men with varicocele is associated with sperm motility and grade of varicocele.
Abd-Elmoaty
Mohamed Ahmed
MA
Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Sohag, Egypt.
Saleh
Ramadan
R
Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt.
Sharma
Rakesh
R
Center for Reproductive Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio.
Agarwal
Ashok
A
Center for Reproductive Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address: agarwaa@ccf.org.
D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000378:metabolism; D016022:Case-Control Studies; D002374:Catalase / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D016877:Oxidants / Q000378:metabolism*; D012661:Semen / Q000378:metabolism*; D055101:Semen Analysis; D013482:Superoxide Dismutase / Q000378:metabolism; D015854:Up-Regulation; D014646:Varicocele / Q000150:complications / Q000378:metabolism*
D000975:Antioxidants; D016877:Oxidants; D009569:Nitric Oxide; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001205:Ascorbic Acid