Acute toxicity effects of Prunus avium fruit extract and selection of optimum dose against radiation exposure.
The objective of the study was to evaluate the acute toxicity of different doses of the methanolic extract of the fruit pulp of Prunus avium (family Rosaceae), which is used ethno-medicinally for the treatment of various diseases, and to find out the optimal dose of Prunus avium extract against 10 Gy gamma-radiation exposure. To test acute toxicity in mice, different doses of PAE (Prunus avium fruit extract) were given orally for 15 consecutive days, after which the animals were observed for another 15 days; the LD50/15 of the methanolic extract was calculated to be 4.947 gm/kg body weight (b.wt). In optimum dose selection against radiation exposure, oral administration of 450 mg/kg b.wt/d of PAE for 15 consecutive days before exposure to 10 Gy of gamma-radiation was found to afford maximum protection in terms of body weight and survivability of the mice in comparison to other doses.
Sisodia
Rashmi
R
Department of Zoology, University of Rajasthan, Jaipur, Rajasthan 302055, India. rashsisodia@yahoo.co.in
Sharma
K
K
Singh
Smita
S
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000633:toxicity*; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use / Q000633:toxicity*; D027861:Prunus / Q000633:toxicity*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D023382:Toxicity Tests, Acute
D010936:Plant Extracts; D011837:Radiation-Protective Agents