Hypertension in long-term survivors of childhood cancer: a nested case-control study.
OBJECTIVE
To examine risk factors for developing hypertension in childhood cancer survivors (CCS).


METHODS
We conducted a nested case-control study of risk for hypertension within a cohort of 1362 childhood cancer survivors treated between 1966 and 1996 in the Emma's Children's Hospital/Academic Medical Center in the Netherlands. Detailed information on treatment and several lifestyle factors was collected for 44 cases with hypertension and 123 matched controls. Odds ratios (ORs) for hypertension were calculated by conditional logistic regression analysis.


RESULTS
Body Mass Index (BMI) was the only significant risk factor associated with the occurrence of hypertension (OR 3.95; 95% confidence interval (CI) 1.7-9.1 for BMI25kg/m(2) compared to BMI<25kg/m(2)). However, cisplatin, cyclophosphamide and radiotherapy (RT) to the abdominal region were all associated with non-significant risk increases (ORs of 4.3, 2.1, and 1.8, respectively).


CONCLUSIONS
Our results show that BMI is the most important risk factor for hypertension following treatment of childhood cancer, emphasising the need for CCS to maintain a normal weight.
Cardous-Ubbink
M C
MC
Long-Term Follow-Up Clinic, Department of Paediatric Oncology, Emma Kinderziekenhuis AMC, Academic Medical Center, Amsterdam, The Netherlands.
Geenen
M M
MM
Schade
K J
KJ
Heinen
R C
RC
Caron
H N
HN
Kremer
L C M
LC
Van Leeuwen
F E
FE
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000970:Antineoplastic Agents / Q000009:adverse effects; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D007223:Infant; D007231:Infant, Newborn; D008019:Life Style; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects; D017741:Survivors; D013997:Time Factors; D055815:Young Adult
D000970:Antineoplastic Agents