title: Randomized comparison of OASIS wound matrix versus moist wound dressing in the treatment of difficult-to-heal wounds of mixed arterial/venous etiology.
abstract: OBJECTIVE
  In this study, a biological extracellular matrix was compared with a moist wound dressing to determine its effectiveness in the treatment of mixed arterial/venous and venous ulcers.
  
  
  METHODS
  Patients were evaluated for complete wound healing, time to dressing change, and formation of granulation tissue.
  
  
  RESULTS
  Extracellular matrix-treated ulcers achieved complete healing on average in 5.4 weeks as compared with 8.3 weeks for the control group treated with moist wound dressing (P = .02). At the primary time point evaluated (8 weeks), complete wound closure was achieved in 80% of extracellular matrix-treated ulcers compared with 65% of ulcers in the control group (P < .05). Statistically significant differences favoring the extracellular-matrix treatment group were also reported for time to dressing change (P < .05), and for percentage of granulation tissue formed (P < .05).
  
  
  CONCLUSIONS
  Overall, the biological extracellular matrix was more beneficial than moist wound dressings for the treatment of patients with mixed arterial/venous or venous ulcers.
authors.affiliation: Department of Dermatology, University of Pisa, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Romanelli
authors.forename: Valentina
authors.initials: V
authors.lastname: Dini
authors.forename: Maria Stefania
authors.initials: MS
authors.lastname: Bertone
mesh_terms: D000818:Animals; D001684:Biological Dressings; D005109:Extracellular Matrix; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology / Q000628:therapy*; D008297:Male; D011446:Prospective Studies; D013552:Swine; D014945:Wound Healing; D014947:Wounds and Injuries / Q000209:etiology / Q000628:therapy*