title: Solitary cystic cerebral metastasis from transitional cell carcinoma of the bladder.
abstract: Metastatic brain tumors are the most common intracranial neoplasm in adults. Bladder cancer gives metastasis to the brain in less than 1%. Herewith, we report on a case of a 71-year-old man who was admitted to the emergency department after an episode of loss of consciousness. On neurological examination a left hemiparesis was observed. The patient's previous history entailed a total cystectomy and radical prostatectomy 7 months ago because of a transitional cell carcinoma (TCC) of the urinary bladder. Brain imaging work-up revealed a cystic lesion with perifocal edema in the right frontal lobe. The patient was operated and the histological diagnosis was consistent with a metastatic carcinoma, with morphological, histochemical and immunohistochemical features comparable to those of the primary tumor. Postoperative the patient was in excellent neurological state and received complementary chemotherapy and total brain irradiation. Additional imaging and laboratory examinations excluded other metastatic lesion. The patient died 18 months later due to systemic disease. Although intracranial metastases from TCC of urinary bladder have a low incidence, in follow-up examinations any alterations in neurological status in these patients should be thoroughly evaluated.
authors.affiliation: Department of Neurosurgery, University Hospital of Ioannina, Greece.
authors.forename: Andreas
authors.initials: A
authors.lastname: Zigouris
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Pahatouridis
authors.forename: Evaggelos
authors.initials: E
authors.lastname: Mihos
authors.forename: George A
authors.initials: GA
authors.lastname: Alexiou
authors.forename: John
authors.initials: J
authors.lastname: Nesseris
authors.forename: Anastasia K
authors.initials: AK
authors.lastname: Zikou
authors.forename: Maria I
authors.initials: MI
authors.lastname: Argyropoulou
authors.forename: Anna
authors.initials: A
authors.lastname: Goussia
authors.forename: Spyridon
authors.initials: S
authors.lastname: Voulgaris
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000556:secondary* / Q000628:therapy; D002295:Carcinoma, Transitional Cell / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D015653:Cystectomy; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D001749:Urinary Bladder Neoplasms / Q000473:pathology*