title: Infectious canine hepatitis in red foxes (Vulpes vulpes) in the United Kingdom.
abstract: The pathological findings are described in three cases of infectious canine hepatitis in free-ranging red foxes (Vulpes vulpes) in England. The foxes died after short periods of clinical illness. Mild jaundice and hepatic congestion were evident grossly. On histopathological examination, intranuclear inclusion bodies were visible in hepatocytes, in association with hepatocyte dissociation and necrosis, as well as in renal glomeruli, renal tubular epithelial cells and vascular endothelial cells. Canine adenovirus type 1 (CAV-1) was isolated from all three foxes. In a serological study, antibodies to CAV-1 were detected in tissue fluid extracts taken from 11 of 58 (19 per cent) frozen red fox carcases from England and Scotland.
authors.affiliation: Division of Pathological Sciences, Institute of Comparative Medicine, University of Glasgow, Faculty of Veterinary Medicine, Garscube Estate, Bearsden Road, Glasgow G61 1QH.
authors.forename: H
authors.initials: H
authors.lastname: Thompson
authors.forename: A M
authors.initials: AM
authors.lastname: O'Keeffe
authors.forename: J C M
authors.initials: JC
authors.lastname: Lewis
authors.forename: L R
authors.initials: LR
authors.lastname: Stocker
authors.forename: M K
authors.initials: MK
authors.lastname: Laurenson
authors.forename: A W
authors.initials: AW
authors.lastname: Philbey
mesh_terms: D006516:Adenoviruses, Canine / Q000276:immunology / Q000302:isolation & purification*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004285:Dogs; D017809:Fatal Outcome; D005589:Foxes / Q000276:immunology / Q000821:virology*; D006522:Hepatitis, Infectious Canine / Q000175:diagnosis* / Q000473:pathology; D022781:Hepatocytes / Q000473:pathology; D045586:Intranuclear Inclusion Bodies; D007565:Jaundice / Q000209:etiology / Q000662:veterinary; D007672:Kidney Cortex / Q000473:pathology; D006113:United Kingdom
chemical_list: D000914:Antibodies, Viral