title: Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop.
abstract: Radiation exposures from accidents, nuclear detonations or terrorist incidents are unlikely to be homogeneous; however, current biodosimetric approaches are developed and validated primarily in whole-body irradiation models. A workshop was held at the Armed Forces Radiobiology Research Institute in May 2008 to draw attention to the need for partial-body biodosimetry, to discuss current knowledge, and to identify the gaps to be filled. A panel of international experts and the workshop attendees discussed the requirements and concepts for a path forward. This report addresses eight key areas identified by the Workshop Program Committee for future focus: (1) improved cytogenetics, (2) clinical signs and symptoms, (3) cutaneous bioindicators, (4) organ-specific biomarkers, (5) biophysical markers of dose, (6) integrated diagnostic approaches, (7) confounding factors, and (8) requirements for post-event medical follow-up. For each area, the status, advantages and limitations of existing approaches and suggestions for new directions are presented.
authors.affiliation: Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889, USA. patajeprasanna@mail.nih.gov
authors.forename: Pataje G S
authors.initials: PG
authors.lastname: Prasanna
authors.forename: William F
authors.initials: WF
authors.lastname: Blakely
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Bertho
authors.forename: John P
authors.initials: JP
authors.lastname: Chute
authors.forename: Eric P
authors.initials: EP
authors.lastname: Cohen
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Goans
authors.forename: Marcy B
authors.initials: MB
authors.lastname: Grace
authors.forename: Patricia K
authors.initials: PK
authors.lastname: Lillis-Hearne
authors.forename: David C
authors.initials: DC
authors.lastname: Lloyd
authors.forename: Ludy C H W
authors.initials: LC
authors.lastname: Lutgens
authors.forename: Viktor
authors.initials: V
authors.lastname: Meineke
authors.forename: Natalia I
authors.initials: NI
authors.lastname: Ossetrova
authors.forename: Alexander
authors.initials: A
authors.lastname: Romanyukha
authors.forename: Julie D
authors.initials: JD
authors.lastname: Saba
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Weisdorf
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wojcik
authors.forename: Eduardo G
authors.initials: EG
authors.lastname: Yukihara
authors.forename: Terry C
authors.initials: TC
authors.lastname: Pellmar
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D006801:Humans; D011832:Radiation Injuries / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*
chemical_list: D015415:Biomarkers