[Survey of the evolutionary characteristics of influenza H1N1 hemagglutinin gene HA1 in 2000-2009].
OBJECTIVE
To study the global evolutionary characteristics of hemagglutinin gene HA1 of influenza H1N1 infecting different species during 2000-2009.


METHODS
The target sequences were downloaded from NCBI and analyzed using bioinformatic software to construct the phylogenetic tree.


RESULTS
The HA1 amino acid sequences of influenza H1N1 contained four mutated antigenic sites and receptor-binding sites, and the novel influenza virus shared most of the mutated amino acid sites with swine H1N1 influenza virus.


CONCLUSIONS
The HA1 gene of novel influenza virus might originate from the early swine H1N1 influenza virus from North America, and in the evolutionary process, a number of important sites of HA1 gene mutated to result in the outbreak of influenza.
Wang
Ni-sha
NS
Institute of Genetic Engineering, Southern Medical University, Guangzhou 510515, China. wns425426@yahoo.com.cn
Ma
Wen-li
WL
Zhao
Hai-quan
HQ
Wei
Min
M
Zhang
Bao
B
Zhang
Wen-ling
WL
Xiang
Xing-yu
XY
D000940:Antigenic Variation; D002681:China / Q000453:epidemiology; D019295:Computational Biology; D005814:Genes, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics*; D007251:Influenza, Human / Q000453:epidemiology / Q000821:virology*; D009154:Mutation; D010802:Phylogeny
C543345:H1N1 virus hemagglutinin; D019267:Hemagglutinin Glycoproteins, Influenza Virus