Antihyperglycemic and antihyperlipidemic activities of methanol:water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats.
The present study was taken up to identify potent antihyperglycemic fraction from the aqueous extract of Syzygium alternifolium (SA) seeds, using bioassay guided fractionation. The isolated fraction C at a dose of 50 mg/kg.b.w produced the maximum fall of 83% in the blood glucose level in the diabetic rats after 6 h of the treatment. The administration of fraction C (50 mg/kg.b.w) once daily for 30 days in STZ diabetic rats resulted in a significant decrease in blood glucose, glycosylated haemoglobin with a significant rise in plasma insulin level. Further fraction C showed antihyperlipidemic activity as evidenced by significant decrease in serum TC, TG, LDL-C, VLDL-C levels coupled together with elevation of HDL-C level in diabetic rats. A significant decrease in the activities of SGOT, SGPT, ALP and decreased levels of serum urea and creatinine in diabetic treated rats when compared to diabetic untreated rats, indicate the protective role against liver and kidney damage and non-toxic property of the fraction C. A comparison was made between the action of fraction C and antidiabetic drug glibenclamide (20 mg/kg.b.w). The effect of fraction C was more prominent when compared to that of glibenclamide.
Kasetti
Ramesh Babu
RB
Department of Biochemistry, Sri Venkateswara University, Tirupati 517502, AP, India.
Rajasekhar
Maddirala Dilip
MD
Kondeti
Vinay Kumar
VK
Fatima
Shaik Sameena
SS
Kumar
Ethamakula Guravaiah Tiruvenkata
EG
Swapna
Sirasanagandla
S
Ramesh
Bellamkonda
B
Rao
Chippada Appa
CA
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects; D005591:Chemical Fractionation; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D005905:Glyburide / Q000494:pharmacology; D006442:Glycated Hemoglobin / Q000032:analysis / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008111:Liver Function Tests; D008297:Male; D000432:Methanol / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry; D013311:Streptozocin; D027842:Syzygium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001219:Aspartate Aminotransferases; D001786:Blood Glucose; D005905:Glyburide; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007328:Insulin; D008055:Lipids; D000432:Methanol; D010936:Plant Extracts; D013311:Streptozocin; D014867:Water