Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction.
Tumor necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory molecule, which upon engagement with its cognate receptors on target cells, triggers downstream signaling cascades that control a number of cellular processes related to cell viability, gene expression, ion homeostasis, and synaptic integrity. In the central nervous system (CNS), TNF-alpha is produced by brain-resident astrocytes, microglia, and neurons in response to numerous intrinsic and extrinsic stimuli. This review will summarize the key events that lead to TNF-alpha elaboration in the CNS, and the effects that these inflammatory signals impart on neuronal signaling in the context of homeostasis and neuropathology.
Park
Keigan M
KM
Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Bowers
William J
WJ
D000544:Alzheimer Disease / Q000209:etiology; D000818:Animals; D001921:Brain / Q000196:embryology; D002470:Cell Survival; D006706:Homeostasis; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D051379:Mice; D009473:Neuronal Plasticity; D009474:Neurons / Q000378:metabolism*; D010300:Parkinson Disease / Q000209:etiology; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
D007473:Ion Channels; D014409:Tumor Necrosis Factor-alpha