title: Ranibizumab for idiopathic retinal vasculitis, aneurysms, and neuroretinitis: favorable results.
abstract: OBJECTIVE
  Idiopathic retinitis, vasculitis, aneurysms, and neuroretinitis (IRVAN) is a rare syndrome that can progress rapidly to severe visual loss mainly due to the development of proliferative retinopathy despite aggressive therapeutic retinal photocoagulation or pars plana vitrectomy. We report a case of IRVAN treated with ranibizumab as an adjunctive treatment of IRVAN.
  
  
  METHODS
  Interventional case report. A 50-year-old woman was diagnosed with IRVAN. Complete ocular and systemic examination and fundus fluorescein angiography were performed to evaluate the patient. Treatment with 2 monthly intravitreal injections of 0.5 mg ranibizumab was initiated for each eye followed by panretinal photocoagulation (PRP) in the right eye (RE) and pars plana vitrectomy, endolaser, and additional PRP in the left eye (LE).
  
  
  RESULTS
  Immediate regression of optic nerve neovascularization in the RE was noted after ranibizumab treatment. One year after initial presentation, best-corrected visual acuity was 20/20 in the RE and 20/50 in the LE and results of fundus examination have shown complete regression of neovascularization bilaterally.
  
  
  CONCLUSIONS
  We propose a modified treatment modality for stage 3 IRVAN with the adjunctive use of ranibizumab. Our patient has shown complete regression of posterior segment neovascularization accompanied with significant improvement of her visual acuity. Ranibizumab seems to have encouraging results as an adjunctive treatment of IRVAN.
authors.affiliation: First Department of Ophthalmiatrion Athinon, Athens Eye Hospital, Athens, Greece. dimitrioskaragiannis@doctors.org.uk
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Karagiannis
authors.forename: Vasileios
authors.initials: V
authors.lastname: Soumplis
authors.forename: Ilias
authors.initials: I
authors.lastname: Georgalas
authors.forename: Artemios
authors.initials: A
authors.lastname: Kandarakis
mesh_terms: D000783:Aneurysm / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D061067:Antibodies, Monoclonal, Humanized; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D058449:Intravitreal Injections; D008875:Middle Aged; D000069579:Ranibizumab; D031300:Retinal Vasculitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D012171:Retinal Vessels; D012173:Retinitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000069579:Ranibizumab