title: Role of hypo-osmotic saline drops in ocular comfort during contact lens wear.
abstract: OBJECTIVE
  To determine whether hypo-osmotic saline drops can improve contact lens associated discomfort and dryness by decreasing contact lens osmolality.
  
  
  METHODS
  Fifteen symptomatic subjects wore Lotrafilcon A lenses bilaterally for 6h on two different days. According to randomisation, hypo-osmotic (280mmol/kg) or hyper-osmotic (380mmol/kg) saline drops were applied four times during each day and ocular symptoms, tear film and contact lens parameters, and contact lens osmolality were assessed.
  
  
  RESULTS
  Sixty percent of the subjects preferred the hypo-osmotic saline drops, compared to 33%, who preferred the hyper-osmotic ones. Subjects experienced significantly less dryness and lens awareness with hypo-osmotic saline drops compared to hyper-osmotic ones (p<0.05). Using the hypo-osmotic drops, there was a trend for decreased contact lens osmolality from 379 to 343mmol/kg (p=0.06). There were no differences in lipid layer, non-invasive tear film break-up time, lens surface wettability, lens water content after wear, lens movement on eye or ocular staining and indentation between saline drops (all p>0.05). Interestingly, the difference in contact lens osmolality between drops did not reflect the osmolality difference between the two saline drops.
  
  
  CONCLUSIONS
  Hypo-osmotic saline drops were preferred by a greater number of subjects and contact lens osmolality tended to be lower with the use of hypo-osmotic saline. Hypo-osmotic drops have the potential to decrease contact lens osmolality which in turn may help improve ocular comfort. This has possible impact on the practitioners' choice of the lens rewetting drop recommended and the design of future lens rewetting drops.
authors.affiliation: The Vision Cooperative Research Centre, Sydney, Australia. u.stahl@unsw.edu.au
authors.forename: Ulrike
authors.initials: U
authors.lastname: Stahl
authors.forename: Mark
authors.initials: M
authors.lastname: Willcox
authors.forename: Fiona
authors.initials: F
authors.lastname: Stapleton
mesh_terms: D000328:Adult; D003261:Contact Lenses / Q000009:adverse effects*; D015352:Dry Eye Syndromes / Q000209:etiology* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D012965:Sodium Chloride / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D009883:Ophthalmic Solutions; D012965:Sodium Chloride