Multiscale modelling of fluid and drug transport in vascular tumours.
A model for fluid and drug transport through the leaky neovasculature and porous interstitium of a solid tumour is developed. The transport problems are posed on a micro-scale characterized by the inter-capillary distance, and the method of multiple scales is used to derive the continuum equations describing fluid and drug transport on the length scale of the tumour (under the assumption of a spatially periodic microstructure). The fluid equations comprise a double porous medium, with coupled Darcy flow through the interstitium and vasculature, whereas the drug equations comprise advection-reaction equations; in each case the dependence of the transport coefficients on the vascular geometry is determined by solving micro-scale cell problems.
Shipley
Rebecca J
RJ
Mathematical Institute, 24-29 St. Giles, Oxford, OX1 3LB, UK. shipley@maths.ox.ac.uk
Chapman
S Jonathan
SJ
D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D001692:Biological Transport; D002196:Capillaries / Q000473:pathology; D006801:Humans; D008954:Models, Biological; D019043:Vascular Neoplasms / Q000098:blood supply* / Q000188:drug therapy / Q000378:metabolism*
D000970:Antineoplastic Agents