title: Isolation of C11 cyclopentenones from two didemnid species, Lissoclinum sp. and Diplosoma sp.
abstract: A series of new C(11) cyclopentenones 1-7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8-12. The structures of 1-7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).
authors.affiliation: Department of Chemistry, Biology and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa, Japan. ogitkyuk@pref.okinawa.lg.jp
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ogi
authors.forename: Palupi
authors.initials: P
authors.lastname: Margiastuti
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Teruya
authors.forename: Junsei
authors.initials: J
authors.lastname: Taira
authors.forename: Kiyotake
authors.initials: K
authors.lastname: Suenaga
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Ueda
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D003517:Cyclopentanes / Q000737:chemistry* / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship; D014561:Urochordata / Q000737:chemistry*
chemical_list: D003517:Cyclopentanes; C013905:cyclopentenone