title: Metabolic programming of lipid profile and reproductive organs weight by leptin treatment on early life.
abstract: OBJECTIVE
  To evaluate whether the neonatal leptin treatment during the first days of life can program the male reproductive organs weight and the lipid profile.
  
  
  METHODS
  At birth 6 dams were divided into 2 groups: Leptin - each pup was injected with 50microL of recombinant rat leptin (80ng/g BW, sc), for the first 10 d of lactation; Control - each pup received the same volume of saline. After weaning, all pups received unlimited access to food until 190 days of age when they were killed. Values are given as mean + or - SEM of 6 animals and Test t Student was used to analyze the results.
  
  
  RESULTS
  The leptin treatment resulted in a significant increase in body weight (Control= 411.8 + or - 16.31; Leptin= 481.8 + or - 11.29, p=0.005) and food consumption (Control= 25.32 + or - 0.09; Leptin= 32.42 + or - 0.15, p=0.0001) and a significant reduction in triglycerides levels (Control= 540.0 + or - 117.9; Leptin= 93.25 + or - 15.21, p=0.006) and in the weight of hypothalamus (Control= 0.234 + or - 0.016; Leptin= 0.154 + or - 0.015, p=0.007), pituitary (Control= 0.104 + or - 0.0120; Leptin= 0.033 + or - 0.012, p=0.003), testis (Control= 3.75 + or - 0.055; Leptin= 3.19 + or - 0.10, p=0.002) and prostate (Control=1.641 + or - 0.1389; Leptin= 0.91 + or - 0.07, p=0.001).
  
  
  CONCLUSIONS
  Leptin treatment on the first days of life can program the reproductive organs weight and the lipid profile of the progeny.
authors.affiliation: Urogenital Research Unit, UERJ, Rio de Janeiro, Brazil.
authors.forename: Durval Santos
authors.initials: DS
authors.lastname: Marques
authors.forename: Flávia Meireles
authors.initials: FM
authors.lastname: Gombar
authors.forename: Jorge Luiz Alves
authors.initials: JL
authors.lastname: Pereira
authors.forename: Francisco José Barcellos
authors.initials: FJ
authors.lastname: Sampaio
authors.forename: Cristiane da Fonte
authors.initials: Cda F
authors.lastname: Ramos
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling / Q000502:physiology; D005837:Genitalia, Male / Q000033:anatomy & histology / Q000187:drug effects*; D020738:Leptin / Q000494:pharmacology*; D008055:Lipids / Q000502:physiology*; D008297:Male; D023421:Models, Animal; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D020738:Leptin; D008055:Lipids