An efficient, mild and solvent-free synthesis of benzene ring acylated harmalines.
A facile synthesis of a series of benzene ring acylated analogues of harmaline has been achieved by Friedel-Crafts acylation under solvent-free conditions at room temperature using acyl halides/acid anhydrides and AlCl3. The reaction afforded 10- and 12-acyl analogues of harmaline in good yield, along with minor quantities of N-acyl-tryptamines and 8-acyl analogues of N-acyltryptamines.
Begum
Sabira
S
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. sabira@khi.comsats.net.pk
Zubair
Farhat
F
Nawazish
Ali Syed
AS
Siddiqui
Bina Shaheen
BS
D000215:Acylation; D001554:Benzene / Q000737:chemistry*; D002625:Chemistry, Organic / Q000379:methods*; D006246:Harmaline / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D012997:Solvents / Q000737:chemistry*
D012997:Solvents; D006246:Harmaline; D001554:Benzene