title: Stromal issues in cervical cancer: a review of the role and function of basement membrane, stroma, immune response and angiogenesis in cervical cancer development.
abstract: The carcinogenesis of cervical carcinoma implies an intricate interplay of neoplastic, human papillomavirus infected epithelial cells and stromal tissue, in which different factors have distinct but interacting influence. Persistent infection with an oncogenic human papillomavirus type may lead to epithelial dysplasia with progressive severity. To access the adjacent stromal tissue, tumour cells have to breach the basement membrane. The stroma partly controls tumour growth, invasion and angiogenesis. Last but not least there is considerable influence of the immune response. In this review we describe the importance of various stromal factors in carcinogenesis of cervical cancer.
authors.affiliation: University of Antwerp, Belgium. Shaira.Sahebali@ua.ac.be
authors.forename: Shaira
authors.initials: S
authors.lastname: Sahebali
authors.forename: Gert
authors.initials: G
authors.lastname: Van den Eynden
authors.forename: Eddie F
authors.initials: EF
authors.lastname: Murta
authors.forename: Marcia A
authors.initials: MA
authors.lastname: Michelin
authors.forename: Pino
authors.initials: P
authors.lastname: Cusumano
authors.forename: Patrick
authors.initials: P
authors.lastname: Petignat
authors.forename: Johannes J
authors.initials: JJ
authors.lastname: Bogers
mesh_terms: D001485:Basement Membrane / Q000502:physiology*; D005260:Female; D006801:Humans; D020782:Matrix Metalloproteinases / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000209:etiology*; D017154:Stromal Cells / Q000502:physiology*; D002583:Uterine Cervical Neoplasms / Q000098:blood supply / Q000209:etiology* / Q000276:immunology / Q000473:pathology
chemical_list: D020782:Matrix Metalloproteinases