title: Transthoracic defibrillation potential gradients in a closed chest porcine model of prolonged spontaneous and electrically induced ventricular fibrillation.
abstract: OBJECTIVE
  The purpose of this study was to measure the local electrical field or potential gradient, measured with a catheter-based system, required to terminate long duration electrically or ischaemically induced ventricular fibrillation (VF). We hypothesized that prolonged ischaemic VF would be more difficult to terminate when compared to electrically induced VF of similar duration.
  
  
  METHODS
  Thirty anesthetized and instrumented swine were randomized to electrically induced VF or spontaneous, ischaemically induced VF, produced by balloon occlusion of the left anterior descending coronary artery. After 7 min of VF, chest compressions were initiated and rescue shocks were attempted 1 min later. The potential gradient for each shock was measured and the mean values required for defibrillation compared for the VF groups.
  
  
  RESULTS
  The number of shocks and the shock strength required for termination of VF were not significantly different for the groups. The potential gradient of the first successful defibrillating shock was significantly greater in the spontaneous, occlusion-induced VF group (12.80+/-2.82 V/cm vs 9.60+/-2.48 V/cm, p=0.002). The number of refibrillations was greater in the ischaemic group than in the non-ischaemic electrical group (6+/-4 vs 1+/-1, p<0.001). The number of animals requiring a shock at 360J was 2.5 times greater for the ischaemic group.
  
  
  CONCLUSIONS
  Defibrillation of prolonged VF produced by acute myocardial ischaemia requires a significantly greater potential gradient to terminate than prolonged VF induced by electrical stimulation of the right ventricular endocardium. The VF duration used in this study approximates that occurring in victims of out-of-hospital cardiac arrest. Our findings may be of clinical importance in the management of such patients.
authors.affiliation: The David Geffen School of Medicine at UCLA, Los Angeles, CA, United States. jniemann@emedharbor.edu
authors.forename: James T
authors.initials: JT
authors.lastname: Niemann
authors.forename: John P
authors.initials: JP
authors.lastname: Rosborough
authors.forename: Scott T
authors.initials: ST
authors.lastname: Youngquist
authors.forename: Atman P
authors.initials: AP
authors.lastname: Shah
mesh_terms: D000208:Acute Disease; D000818:Animals; D004554:Electric Countershock / Q000379:methods*; D004558:Electric Stimulation; D005260:Female; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications*; D013552:Swine; D014693:Ventricular Fibrillation / Q000209:etiology / Q000628:therapy*