title: Quantifying degree of mastitis from common trends in a panel of indicators for mastitis in dairy cows.
abstract: This paper has 2 objectives. First, it argues that it is beneficial to regard degree of infection with respect to mastitis as a latent quantity varying continuously from 0 (truly healthy) to 1 (full-blown clinical mastitis). This quantity is denoted as degree of infection (DOI). The DOI is based on extracting common characteristics from a panel of indicators measured repeatedly over time. The indicators used in this paper are electrical conductivity (EC), somatic cell count (SCC), and the immune response related enzyme lactate dehydrogenase (LDH). Second, this paper presents a statistical model for such data and a corresponding method for estimating the DOI from a panel of indicators. An empirical proof of concept is provided. Using DOI, there was a significant difference between the DOI of mastitic and healthy control cows beginning 5 d before the mastitic cows were treated for mastitis.
authors.affiliation: Faculty of Agricultural Sciences, Aarhus University, Tjele, DK-8830, Denmark. sorenh@agrsci.dk
authors.forename: S
authors.initials: S
authors.lastname: Højsgaard
authors.forename: N C
authors.initials: NC
authors.lastname: Friggens
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D002417:Cattle; D003612:Dairying / Q000379:methods*; D004553:Electric Conductivity; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008414:Mastitis, Bovine / Q000175:diagnosis* / Q000201:enzymology / Q000503:physiopathology; D008892:Milk / Q000166:cytology; D015233:Models, Statistical; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D007770:L-Lactate Dehydrogenase