Hypoglycemic activity and antioxidant potential of some medicinal plants traditionally used in Turkey for diabetes.
Cydonia oblonga Mill. (Rosaceae) leaves, Helianthus tuberosus L. (Asteraceae) tubers, and Allium porrum L. (Liliaceae) bulbs are used as a folk remedy for the treatment of diabetes and they are also consumed as food in Turkey. In the present study, the antidiabetic and antioxidant activities of the ethanol extracts of these plants were studied in normal and streptozotocin-induced diabetic rats for 5 days. All extracts were administrated orally to rats at the doses of 250 and 500 mg/kg. Blood glucose level was measured according to glucose oxidase method. In order to determine antioxidant activity, thiobarbituric acid reactive substance (TBARS) and reduced glutathione (GSH) levels in liver, kidney, and heart tissues were measured by using spectrophotometric methods. Oral administration of Cydonia oblonga (500 mg/kg) and Allium porrum (500 mg/kg) extracts for 5 days in diabetic rats caused a decrease in blood glucose levels by 33.8% and 18.0%, respectively. Moreover, Allium porrum and Cydonia oblonga extracts induced significant alleviation on only heart tissue TBARS levels (44.6 and 45.7%), Helianthus tuberosus and Allium porrum extracts showed an inhibitory effect on kidney tissue TBARS levels (24.5 and 14.8%). None of the extracts restored GSH levels in kidney, liver, and heart tissues of diabetic rats.
Aslan
Mustafa
M
Faculty of Pharmacy, Department of Pharmacognosy, Gazi University, 06330 Ankara, Turkey. marslan@gazi.edu.tr
Orhan
Nilüfer
N
Orhan
Didem Deliorman
DD
Ergun
Fatma
F
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D000431:Ethanol / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008519:Medicine, Traditional; D009206:Myocardium / Q000378:metabolism; D018515:Plant Leaves / Q000378:metabolism; D010946:Plants, Medicinal / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000009:adverse effects; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014421:Turkey
D000975:Antioxidants; D007004:Hypoglycemic Agents; D017392:Thiobarbituric Acid Reactive Substances; D000431:Ethanol; D013311:Streptozocin; D005978:Glutathione