title: Afect of botulinum toxin-A injection on intraocular pressure and proptosis in thyroid associated orbitopathy.
abstract: The aim of this study was to evaluate the effects of extraocular muscle injection of botulinum toxin-A (BTX-A) on intraocular pressure (IOP) and proptosis in patients with ocular motility disturbances in thyroid associated orbitopathy (TAO). In 17 patients (20 eyes) with restrictive strabismus and diplopia, BTX-A injections were applied. Intraocular pressure was measured with a Goldmann applanation tonometer in primary gaze position before and 2-4 weeks after BTX-A injection. Extraorbital prominention of the eyeball was measured before and after BTX-A injection using a Hertel instrument. Before the injection, the mean IOP in primary position of gaze was 18.6 +/- 2.8 mmHg and 2-4 weeks after BTX-A injection was 16.9 +/- 3.3 mmH; (p = 0.001). There was no statistically significant difference in Hertel egzophthalmometer readings before and after BTX-A injection, 21.5 +/- 2.7 mm vs. 22.0 +/- 2.6 mm; (p = 0.678). In conclusion, BTX-A injection has a secondary lowering effect on IOP in TAO due to relaxation of extraocular muscles, but with no influence on proptosis.
authors.affiliation: Eye Department, University Hospital Center Split, Split, Croatia. mladen.lesin@st.t-com.hr
authors.forename: Mladen
authors.initials: M
authors.lastname: Lesin
authors.forename: Lovro
authors.initials: L
authors.lastname: Bojić
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Romac
authors.forename: Josko
authors.initials: J
authors.lastname: Lesin
authors.forename: Milan
authors.initials: M
authors.lastname: Ivanisević
authors.forename: Davor
authors.initials: D
authors.lastname: Galetović
authors.forename: Veljko
authors.initials: V
authors.lastname: Rogosić
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000494:pharmacology* / Q000627:therapeutic use; D005094:Exophthalmos / Q000188:drug therapy; D005260:Female; D049970:Graves Ophthalmopathy / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D009798:Ocular Hypertension / Q000188:drug therapy; D012189:Retrospective Studies
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A