title: Simultaneous EEG-fMRI in patients with Unverricht-Lundborg disease: event-related desynchronization/synchronization and hemodynamic response analysis.
abstract: We performed simultaneous acquisition of EEG-fMRI in seven patients with Unverricht-Lundborg disease (ULD) and in six healthy controls using self-paced finger extension as a motor task. The event-related desynchronization/synchronization (ERD/ERS) analysis showed a greater and more diffuse alpha desynchronization in central regions and a strongly reduced post-movement beta-ERS in patients compared with controls, suggesting a significant dysfunction of the mechanisms regulating active movement and movement end. The event-related hemodynamic response obtained from fMRI showed delayed BOLD peak latency in the contralateral primary motor area suggesting a less efficient activity of the neuronal populations driving fine movements, which are specifically impaired in ULD.
authors.affiliation: Department of Neurophysiopathology, Carlo Besta IRCCS Neurological Institute, 20133 Milan, Italy. visani.e@istituto-besta.it
authors.forename: Elisa
authors.initials: E
authors.lastname: Visani
authors.forename: Ludovico
authors.initials: L
authors.lastname: Minati
authors.forename: Laura
authors.initials: L
authors.lastname: Canafoglia
authors.forename: Isabella
authors.initials: I
authors.lastname: Gilioli
authors.forename: Lucia
authors.initials: L
authors.lastname: Salvatoni
authors.forename: Giulia
authors.initials: G
authors.lastname: Varotto
authors.forename: Patrik
authors.initials: P
authors.lastname: Fazio
authors.forename: Domenico
authors.initials: D
authors.lastname: Aquino
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Bruzzone
authors.forename: Silvana
authors.initials: S
authors.lastname: Franceschetti
authors.forename: Ferruccio
authors.initials: F
authors.lastname: Panzica
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D005385:Fingers / Q000294:innervation; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D009068:Movement / Q000502:physiology; D010100:Oxygen / Q000097:blood; D011597:Psychomotor Performance / Q000502:physiology; D018709:Statistics, Nonparametric; D013997:Time Factors; D020194:Unverricht-Lundborg Syndrome / Q000473:pathology* / Q000503:physiopathology
chemical_list: D010100:Oxygen