title: Plumisclerin A, a diterpene with a new skeleton from the soft coral Plumigorgia terminosclera.
abstract: A novel compound, named plumisclerin A (1), was isolated from samples of the soft coral Plumigorgia terminosclera collected at Mayotte Island. The compound possesses the novel plumisclerane carbon skeleton, including a tricyclo[4,3,1,0(1,5)]decane ring. Its structure and relative stereochemistry were elucidated by extensive spectroscopic analysis, including HREIMS, COSY, HSQC, HMBC, TOCSY, and NOESY experiments. In addition, the novel compound displayed in vitro cytotoxicity against selected cancer cell lines.
authors.affiliation: Medicinal Chemistry Department, PharmaMar S.A., Pol. Ind. La Mina Norte, Avda. de los Reyes 1, 28770 Colmenar Viejo (Madrid), Spain.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Martín
authors.forename: Rogelio
authors.initials: R
authors.lastname: Fernández
authors.forename: Andrés
authors.initials: A
authors.lastname: Francesch
authors.forename: Philippe
authors.initials: P
authors.lastname: Amade
authors.forename: Susana S
authors.initials: SS
authors.lastname: de Matos-Pita
authors.forename: Fernando
authors.initials: F
authors.lastname: Reyes
authors.forename: Carmen
authors.initials: C
authors.lastname: Cuevas
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy
chemical_list: D004224:Diterpenes; C549483:plumisclerin A