title: Faster rate of initial fluid resuscitation in severe acute pancreatitis diminishes in-hospital mortality.
abstract: OBJECTIVE
  We evaluated the impact of the initial intravenous fluid resuscitation rate within the first 24 h of presentation to the emergency room on important outcomes in severe acute pancreatitis.
  
  
  METHODS
  Patients presenting directly with a diagnosis of severe acute pancreatitis were identified retrospectively. Patients were divided into two groups - those who received >or=33% ('early resuscitation') and <33% ('late resuscitation') of their cumulative 72-hour intravenous fluid volume within the first 24 h of presentation. The primary clinical outcomes were in-hospital mortality, development of persistent organ failure, and duration of hospitalization.
  
  
  RESULTS
  17 patients were identified in the 'early resuscitation' group and 28 in the 'late resuscitation' group and there were no baseline differences in clinical characteristics between groups. Patients in the 'late resuscitation' group experienced greater mortality than those in the 'early resuscitation' group (18 vs. 0%, p < 0.04) and demonstrated a trend toward greater rates of persistent organ failure (43 vs. 35%, p = 0.31). There was no difference in the total amount of fluid given during the first 72 h.
  
  
  CONCLUSIONS
  Patients with severe acute pancreatitis who do not receive at least one third of their initial 72-hour cumulative intravenous fluid volume during the first 24 h are at risk for greater mortality than those who are initially resuscitated more aggressively.
authors.affiliation: Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic Rochester, Rochester, Minn., USA.
authors.forename: Timothy B
authors.initials: TB
authors.lastname: Gardner
authors.forename: Santhi Swaroop
authors.initials: SS
authors.lastname: Vege
authors.forename: Suresh T
authors.initials: ST
authors.lastname: Chari
authors.forename: Bret T
authors.initials: BT
authors.lastname: Petersen
authors.forename: Mark D
authors.initials: MD
authors.lastname: Topazian
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Clain
authors.forename: Randall K
authors.initials: RK
authors.lastname: Pearson
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Levy
authors.forename: Michael G
authors.initials: MG
authors.lastname: Sarr
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D017052:Hospital Mortality; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000401:mortality* / Q000628:therapy*; D012189:Retrospective Studies