title: Exercise and weight loss improve exercise capacity independent of cardiac function in metabolic syndrome.
abstract: Hypertension, diabetes and obesity cause cardiac diastolic dysfunction (DD) which could reduce exercise capacity. Our aim was to determine if 10% weight loss by exercise at 60% VO(2max) five days/week (approximately -375 kcal/session) and caloric restriction (approximately -600 kcal/d) over 6 months improves exercise capacity and DD in Metabolic syndrome (MetS). Eighteen subjects (40 +/- 1y, women = 6, BMI = 33.5 +/- 1.0 kg/m(2)) successfully completed the study. Maximal treadmill stress echocardiography was performed at baseline and post weight loss to determine VO(2max), resting and stress DD as the ratio of peak early diastolic mitral inflow velocity (E) to tissue Doppler early diastolic annular decent (E'). After weight loss (mean = 9.5 +/- 0.2%), all metabolic parameters improved. Resting and stress E/E' values remained normal before and after weight loss. Exercise intolerance is likely due to general deconditioning and not cardiac dysfunction in early MetS as VO(2max) increases significantly with lifestyle while cardiac function remains unchanged.
authors.affiliation: Cardiology Section, Harry S Truman VA Medical Center, Columbia, Missouri, USA. chockalingama@health.missouri.edu
authors.forename: Anand
authors.initials: A
authors.lastname: Chockalingam
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Linden
authors.forename: Marc
authors.initials: M
authors.lastname: Del Rosario
authors.forename: Gurushankar
authors.initials: G
authors.lastname: Govindarajan
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Dellsperger
authors.forename: Tom R
authors.initials: TR
authors.lastname: Thomas
mesh_terms: D000328:Adult; D003971:Diastole / Q000502:physiology; D025401:Echocardiography, Stress; D015444:Exercise / Q000502:physiology*; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology*; D009765:Obesity / Q000503:physiopathology; D010101:Oxygen Consumption; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology; D015431:Weight Loss / Q000502:physiology*