Report of a successful treatment of pulmonary Cunninghamella bertholletiae infection with liposomal amphotericin and posaconazole in a child with GvHD and review of the literature.
Zygomycosis is an emerging, opportunistic fungal infection particularly affecting immunocomprised patients. We report the case of a 10-year-old girl who developed pulmonary zygomycosis because of Cunninghamella bertholletiae 1 year after undergoing bone marrow transplantation complicated with severe cutaneous and digestive graft-versus-host disease. Treatment with surgery and liposomal amphotericin B followed by posaconazole successfully treated the infection.
Garbino
Jorge
J
Division of Infectious Diseases, Department of Internal Medicine, University of Geneva Hospitals, Geneva, Switzerland. jorge.garbino@hcuge.ch
Myers
Catherine
C
Ambrosioni
Juan
J
Gumy-Pause
Fabienne
F
D000666:Amphotericin B / Q000008:administration & dosage*; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002648:Child; D020093:Cunninghamella; D004359:Drug Therapy, Combination; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D009091:Mucormycosis / Q000188:drug therapy*; D014230:Triazoles / Q000008:administration & dosage*
D014230:Triazoles; C068538:liposomal amphotericin B; C101425:posaconazole; D000666:Amphotericin B