Primary neuroendocrine carcinoma coexisting with hemangioma in the liver: report of a case.
Primary hepatic neuroendocrine carcinoma is an extremely rare liver tumor. We herein report a case of primary hepatic neuroendocrine carcinoma coexisting with a hemangioma in a 66-year-old man. Ultrasonography, computed tomography, and magnetic resonance imaging showed a tumor (1.5 cm in diameter) coexisting with a hemangioma in the lateral segment of the liver. Liver biopsy showed malignant cells, and several examinations revealed no alternative primary source. We performed a lateral segmentectomy. Microscopically, the tumor cells had round to oval nuclei and eosinophilic cytoplasm, proliferated in thick trabeculae or solid nests, and formed a focal rosette pattern. Mitotic cells were frequently observed. Immunohistochemically, the tumor cells were positive for the endocrine markers chromogranin A, neuron-specific enolase, and neural cell adhesion molecule, but negative for alpha-fetoprotein and hepatocyte-specific antigen. The patient is still alive after 3 months, without recurrence.
Akahoshi
Tomohiko
T
Department of Surgery, Beppu Medical Center, 1473 Oaza-Uchikamado, Beppu, Japan.
Higashi
Hidefumi
H
Tsuruta
Satoru
S
Tahara
Kouichiro
K
Matsumoto
Toshifumi
T
Takeuchi
Hideya
H
Era
Shoichi
S
Fujita
Fuminori
F
Muto
Yoichi
Y
D018278:Carcinoma, Neuroendocrine / Q000000981:diagnostic imaging / Q000473:pathology*; D003937:Diagnosis, Differential; D006391:Hemangioma / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D016896:Treatment Outcome