Apigenin inhibits allergen-induced airway inflammation and switches immune response in a murine model of asthma.
Many flavonoids were demonstrated to possess the antiallergic effect. Here we detected whether apigenin, a flavonoid, can attenuate allergen-induced airway inflammation and what is the possible mechanism in a murine model of asthma. Apigenin decreased the degree of the inflammatory cell infiltration, airway hyperresponsiveness, and total immunoglobulin E levels compared with the ovalbumin group. In addition, apigenin triggered the switching of the immune response to allergens toward a T-helper type 1 (Th1) profile. Our data clearly demonstrated that apigenin exhibits an anti-inflammatory activity in a murine asthma model, and can switch the immune response to allergens toward the Th1 profile.
Li
Ruo-Ran
RR
Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Pang
Ling-Ling
LL
Du
Qiang
Q
Shi
Ying
Y
Dai
Wen-Jing
WJ
Yin
Kai-Sheng
KS
D000485:Allergens / Q000276:immunology*; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D047310:Apigenin / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000276:immunology; D001985:Bronchial Provocation Tests; D005260:Female; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology
D000485:Allergens; D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D007073:Immunoglobulin E; D047310:Apigenin