title: Chorionic villus sampling: analysis of the first 350 singleton pregnancies by a single operator.
abstract: OBJECTIVE
  To assess factors that might influence the success rate, safety and reliability of chorionic villus sampling (CVS).
  
  
  METHODS
  Analysis of the outcome of 350 cases of CVS (215 transabdominal and 135 transvaginal).
  
  
  METHODS
  The outpatient prenatal diagnosis and therapy laboratory of a university tertiary care centre.
  
  
  METHODS
  350 pregnant women that underwent CVS for prenatal genetic diagnosis between nine and 32 gestational weeks.
  
  
  RESULTS
  Fetal genotype was the most common indication for CVS 45% (158/350). The overall sampling success rate was 98% (343/350). The majority of cases, 92% (322/350), required one or two aspirations. Out of 331 cases in which CVS was successful 305 continued with the pregnancy. Thirty-five had therapeutic termination of their pregnancies and ten resulted in spontaneous abortions. There was an overall fetal loss rate of 1.7% (6/350). Early bleeding complications occurred in 11.4% (40/350). PROM 0.86% (3/350), preterm 5.1% (18/350), and placenta disorders 1.1% (4/350) did not exceed the expected values.
  
  
  CONCLUSIONS
  CVS is a relatively safe and reliable method of prenatal genetic diagnosis. It needs be done by experienced personnel.
authors.affiliation: Department of Obstetrics & Gynecology, Prenatal Diagnosis & Therapy Centre, College of Medicine, University of Lagos, Surulere, Lagos, Nigeria. prenataldiagnosiscentre@yahoo.com
authors.forename: G O
authors.initials: GO
authors.lastname: Ajayi
mesh_terms: D015193:Chorionic Villi Sampling / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006785:Hospitals, University; D006801:Humans; D009549:Nigeria; D010044:Outpatient Clinics, Hospital; D011247:Pregnancy; D011446:Prospective Studies; D018084:Ultrasonography, Interventional