Imaginal discs: Renaissance of a model for regenerative biology.
Many animals display a capacity to regenerate tissues or even a complete body. One of the main goals of regenerative biology is to identify the genes and genetic networks necessary for this process. Drosophila offers an ideal model system for such studies. The wide range of genetic and genomic approaches available for use in flies has helped in initiating the deciphering of the mechanisms underlying regeneration, and the results may be applicable to other organisms, including mammals. Moreover, most models of regeneration require experimental manipulation, whereas in Drosophila discrete domains can be ablated by genetically induced methods. Here, we present a summary of current research into imaginal disc regeneration and discuss the power of this tissue as a tool for understanding the genetics of regeneration.
Bergantiños
Cora
C
Facultat de Biologia, Departament de Genètica, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
Vilana
Xavier
X
Facultat de Biologia, Departament de Genètica, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
Corominas
Montserrat
M
Facultat de Biologia, Departament de Genètica, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
Serras
Florenci
F
Facultat de Biologia, Departament de Genètica, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
D000818:Animals; D019521:Body Patterning / Q000502:physiology; D049109:Cell Proliferation; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000196:embryology; D004625:Embryo, Nonmammalian / Q000033:anatomy & histology / Q000502:physiology; D044127:Epigenesis, Genetic; D004848:Epithelium / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D014945:Wound Healing