The many faces of the mitochondrial TIM23 complex.
The TIM23 complex in the inner membrane of mitochondria mediates import of essentially all matrix proteins and a large number of inner membrane proteins. Here we present an overview on the latest insights into the structure and function of this remarkable molecular machine.
Mokranjac
Dejana
D
Institute for Physiological Chemistry and Munich Center for Integrated Protein Science CIPSM, Ludwig-Maximilians University, Butenandtstr. 5, 81377 Munich, Germany. dejana.mokranjac@med.uni-muenchen.de
Neupert
Walter
W
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins / Q000737:chemistry* / Q000378:metabolism*; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D008954:Models, Biological; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000737:chemistry / Q000378:metabolism; D011498:Protein Precursors / Q000737:chemistry / Q000378:metabolism; D021122:Protein Subunits; D021381:Protein Transport; D015398:Signal Transduction
D002352:Carrier Proteins; D033681:Mitochondrial Membrane Transport Proteins; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D046912:Multiprotein Complexes; D011498:Protein Precursors; D021122:Protein Subunits; D000255:Adenosine Triphosphate