title: Aneuploidies of chromosomes 1, 4, and 6 are not compatible with human embryos' implantation.
abstract: OBJECTIVE
  To verify whether chromosomes 1, 4, and 6 have a role in determining oocyte viability.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Reproductive Medicine Unit, Società Italiana Studi Medicina della Riproduzione, Bologna, Italy.
  
  
  METHODS
  Eighty-five patients with a normal karyotype who had undergone an assisted conception cycle with chromosomal analysis of first polar bodies for chromosomes 13, 15, 16, 18, 21, and 22 (first panel). A clinical pregnancy was obtained in 43 patients, whereas 42 patients were not pregnant.
  
  
  METHODS
  After conclusion of clinical pregnancies to delivery or abortion, first polar bodies from 85 patients were reanalyzed for chromosomes 1, 4, and 6 (second panel).
  
  
  METHODS
  Aneuploidy frequency, clinical pregnancy outcome.
  
  
  RESULTS
  The aneuploidy rate contributed by chromosome 1, 4, and 6 to the oocytes that were normal for the first panel was significantly higher in the nonpregnant patients (28%) versus the pregnant patients (11%), whereas no difference resulted between term pregnancies (11%) and abortions (10%). This trend was also observed when studying the first polar bodies from the oocytes that originated the transferred embryos. The frequency of aneuploidy for chromosomes 1 and 4 was comparable with that of chromosomes 15, 16, 21, and 22.
  
  
  CONCLUSIONS
  Aneuploidy of chromosomes 1, 4, and 6 seems to be related to failed implantation and not to spontaneous abortions.
authors.affiliation: Società Italiana Studi Medicina della Riproduzione (S.I.S.Me.R.), Reproductive Medicine Unit, Bologna, Italy.
authors.forename: M Cristina
authors.initials: MC
authors.lastname: Magli
authors.forename: Luca
authors.initials: L
authors.lastname: Gianaroli
authors.forename: Andor
authors.initials: A
authors.lastname: Crippa
authors.forename: Santiago
authors.initials: S
authors.lastname: Munné
authors.forename: Francesca
authors.initials: F
authors.lastname: Robles
authors.forename: Anna P
authors.initials: AP
authors.lastname: Ferraretti
mesh_terms: D000328:Adult; D000782:Aneuploidy; D016022:Case-Control Studies; D002869:Chromosome Aberrations / Q000706:statistics & numerical data; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D010064:Embryo Implantation / Q000235:genetics*; D020964:Embryo Loss / Q000453:epidemiology / Q000235:genetics; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D012189:Retrospective Studies