title: [Prognostic factors after resection of hepatocellular carcinoma in the non-cirrhotic liver: presentation of 51 cases].
abstract: BACKGROUND
  Clinical presentation, treatment and prognosis of hepatocellular carcinoma depend on presence or absence of cirrhosis. In the literature there are few reports of hepatocellular carcinoma in non-cirrhotic patients.
  
  
  OBJECTIVE
  To describe a consecutive series of resected patients with hepatocellular carcinoma in non-cirrhotic liver and to identify prognostic factors of recurrence and survival.
  
  
  METHODS
  Between 1990 and 2006, 51 patients were operated on. Data were retrospectively analysed from a prospectively collected database. Single and multivariate analyses were performed to identify factors associated with survival and disease-free survival.
  
  
  RESULTS
  Thirty-three patients were male, median age 49.8 years. A major hepatectomy was performed in 72%. Morbidity was 43% and mortality was 0%. One-, two- and three-year survival rates were 90%, 75% and 67%, respectively. One-, two- and three-year disease-free survival rates were 65%, 41% and 37%, respectively. Presence of vascular invasion and of positive nodes was statistically significant for survival in univariate analysis but had no statistical significance in multivariate analysis.
  
  
  CONCLUSIONS
  Major hepatic resection is a safe treatment for hepatocellular carcinoma in non-cirrhotic patients. Both vascular invasion and presence of positive nodes were associated with poor survival. However, neither of them represented an independent variable.
authors.affiliation: Servicio de Cirugía General, Sector de Cirugía Hepatobiliopancreática, Hospital Italiano, Buenos Aires, Argentina.
authors.forename: Victoria
authors.initials: V
authors.lastname: Ardiles
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Sánchez Clariá
authors.forename: Oscar M
authors.initials: OM
authors.lastname: Mazza
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Ciardullo
authors.forename: Juan
authors.initials: J
authors.lastname: Pekolj
authors.forename: Eduardo
authors.initials: E
authors.lastname: De Santibañes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000601:surgery*; D002648:Child; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult