title: Novel use of nanostructured alumina as an insecticide.
abstract: BACKGROUND
  The worldwide need to produce an inexpensive and abundant food supply for a growing population is a great challenge that is further complicated by concerns about risks to environmental stability and human health triggered by the use of pesticides. The result is the ongoing development of alternative pest control strategies, and new, lower-risk insecticidal molecules. Among the recent technological advances in agricultural science, nanotechnology shows considerable promise, although its development for use in crop protection is in its initial stages.
  
  
  RESULTS
  This study reports for the first time the insecticidal effect of nanostructured alumina. Two species were used as model organisms, Sitophilus oryzae L. and Rhyzopertha dominica (F.), which are major insect pests in stored food supplies throughout the world. Both species experienced significant mortality after 3 days of continuous exposure to treated wheat. Nine days after treatment, the median lethal doses (LD(50)) observed ranged from 127 to 235 mg kg(-1).
  
  
  CONCLUSIONS
  Comparison of these results with recommended rates for commercial insecticidal dusts suggests that inorganic nanostructured alumina may provide a cheap and reliable alternative for control of insect pests. This study expands the frontiers for nanoparticle-based technologies in pest management. Further research is needed to identify its mode of action and its non-target toxicity, and to determine the potential of other nanostructured materials as pest control options for insects.
authors.affiliation: Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Centro Científico Tecnológico CONICET-Mendoza, Argentina.
authors.forename: Teodoro
authors.initials: T
authors.lastname: Stadler
authors.forename: Micaela
authors.initials: M
authors.lastname: Buteler
authors.forename: David K
authors.initials: DK
authors.lastname: Weaver
mesh_terms: D000537:Aluminum Oxide; D000818:Animals; D001517:Coleoptera; D005511:Food Handling; D007306:Insecticides / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D013997:Time Factors
chemical_list: D007306:Insecticides; D000537:Aluminum Oxide