Anti-TNF-alpha treatment strategies: results and clinical perspectives.
The advent of anti-TNF therapies has led to a significant expansion of the therapeutic armamentarium for inflammatory bowel diseases. Control of inflammation has been achieved with three biologic agents infliximab, adalimumab and certolizumab pegol. All agents are effective in both induction and maintenance of remission. For fistula healing in Crohn's disease, both infliximab and adalimumab have been shown to be effective, whereas for mucosal healing hard evidence is only available for infliximab. Anti-TNF agents appear to be more effective in patients who have a shorter disease history and who have not yet been treated with any of these agents. There is a clear tendency to use anti TNF therapy earlier in the course of inflammatory bowel disease, but predictive markers to select patients who really need these therapies are urgently needed.
D'Haens
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Imelda GI Clinical Research Centre, Imelda General Hospital, Imeldalaan 9, 2820 Bonheiden, Belgium. geert.dhaens@imelda.be
D000068879:Adalimumab; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000068582:Certolizumab Pegol; D003093:Colitis, Ulcerative / Q000188:drug therapy; D003424:Crohn Disease / Q000188:drug therapy; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use*; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D000069285:Infliximab; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012074:Remission Induction; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D007140:Immunoglobulin Fab Fragments; D014409:Tumor Necrosis Factor-alpha; D011092:Polyethylene Glycols; D000069285:Infliximab; D000068879:Adalimumab; D000068582:Certolizumab Pegol