[Effect of Enterobacter cloacae thermolabile enterotoxin on immune system of mice].
OBJECTIVE
To study the effect of Enterobactercloacae thermolabile enterotoxin (LT-enterotoxin) on different arms of immune system of mice.


METHODS
Proprietary clinical strain E. cloacae 258 was used and intraperitoneal inoculation of outbred white mice with LT-enterotoxin-producing E. cloacae comprised experimental model. Phagocytic and lysosomal activity of peritoneal macrophages as well as level of APC to sheep erythrocytes were measured, spontaneous and induced NBT tests were also performed.


RESULTS
Pleiotropic immunotoxic effect of LT-enterotoxin of studied bacteria was established, which characterized by suppres- sion of antigen-presenting and antigen-processing functions of macrophages, stimulation of mitotic activity of lymphocytes, decrease of activity of hexose monophosphate shunt enzymes in peritoneal macrophages as well as abnormalities in formation of specific B-lymphocytes.


CONCLUSIONS
Obtained data allowed to reveal separate steps in pathogenesis of infectious process caused by LT-enterotoxin-producing bacteria from Enterobacter genus.
Akhtarieva
A A
AA
Dolgushin
I I
II
Gabidullin
Z G
ZG
Gabidullin
Iu Z
IuZ
Kamalova
A A
AA
Akhmadeev
R M
RM
D000818:Animals; D017951:Antigen Presentation; D016972:Enterobacter cloacae / Q000276:immunology*; D004756:Enterobacteriaceae Infections / Q000276:immunology*; D004768:Enterotoxins / Q000276:immunology*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D017737:Macrophages, Peritoneal / Q000276:immunology; D008297:Male; D051379:Mice; D010587:Phagocytosis; D012756:Sheep; D013696:Temperature; D013777:Tetrazoles / Q000378:metabolism
D004768:Enterotoxins; D013777:Tetrazoles