title: The physiological stimulus for the BarA sensor kinase.
abstract: The two-component signal transduction system (TCS) BarA/UvrY activates transcription of CsrB and CsrC noncoding RNAs, which act by sequestering the RNA-binding global regulatory protein CsrA. Here, we show that the metabolic end products formate and acetate provide a physiological stimulus for this TCS and thus link posttranscriptional regulation by the Csr system to the metabolic state of the cell.
authors.affiliation: Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico.
authors.forename: Ricardo Gonzalez
authors.initials: RG
authors.lastname: Chavez
authors.forename: Adrian F
authors.initials: AF
authors.lastname: Alvarez
authors.forename: Tony
authors.initials: T
authors.lastname: Romeo
authors.forename: Dimitris
authors.initials: D
authors.lastname: Georgellis
mesh_terms: D019342:Acetic Acid / Q000378:metabolism; D004926:Escherichia coli / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000502:physiology*; D005561:Formates / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D008565:Membrane Proteins / Q000502:physiology*; D010770:Phosphotransferases / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D029968:Escherichia coli Proteins; D005561:Formates; D008565:Membrane Proteins; C030544:formic acid; C074276:barA protein, E coli; D010770:Phosphotransferases; D019342:Acetic Acid