Camptocormia in idiopathic Parkinson's disease: a focal myopathy of the paravertebral muscles.
The objective of our study was to describe the clinical features of camptocormia, an involuntary, marked flexion of the thoracolumbar spine in idiopathic Parkinson's disease (PD) and to understand its etiology. In a prospective, cross-sectional study, we examined 15 patients with PD and camptocormia using laboratory parameters, EMG, muscle magnetic resonance imaging, and biopsy of the paravertebral muscles. The clinical data were compared with a matched control group of PD patients without camptocormia, and the biopsies were compared with muscles from age-matched autopsies. Almost all the patients (median age, 68.0 years; 7 women) with camptocormia suffered from advanced PD. Camptocormia occurred at a median of 9.0 years after the PD diagnosis. Compared with our clinical control group, back pain was more frequent and less dopa-sensitive in the patients with camptocormia who suffered more often from additional diseases of the back. On EMG, we found mainly a myopathic pattern. The MRI of the paravertebral muscles showed localized changes ranging from edema with contrast enhancement, which are considered to be early signs, to atrophy and/or fatty degeneration, interpreted as late degenerative changes. Early signs were seen mainly during the first year and degenerative changes after 1.5 years. Biopsies revealed consistently myopathic changes and in some cases fatty degeneration. Clinical or electromyographic features favoring dystonia were absent. Camptocormia is a major disabling, non-fluctuating and levodopa-resistant complication of advanced PD. The cause of camptocormia in idiopathic PD is a focal myopathy. Our findings suggest that the myopathy has a progressive course, which finally leads to degeneration of the paravertebral muscles.
Margraf
Nils G
NG
Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
Wrede
Arne
A
Rohr
Axel
A
Schulz-Schaeffer
Walter J
WJ
Raethjen
Jan
J
Eymess
Andrea
A
Volkmann
Jens
J
Mehdorn
Maximilian H
MH
Jansen
Olav
O
Deuschl
Günther
G
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D004576:Electromyography / Q000379:methods; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009135:Muscular Diseases / Q000209:etiology* / Q000473:pathology; D010300:Parkinson Disease / Q000150:complications*; D012189:Retrospective Studies; D013121:Spinal Curvatures / Q000150:complications*